locus-tag	class	description
FH978_RS00020	COG0187	DNA topoisomerase II activity
FH978_RS00025	COG0561	phosphatase activity
FH978_RS00040	COG2186	Transcriptional regulator
FH978_RS00045	COG3734	2-keto-3-deoxy-galactonokinase
FH978_RS00050	COG0800	Aldolase
FH978_RS00060	COG2271	Major facilitator Superfamily
FH978_RS00065	COG0823	Involved in the tonB-independent uptake of proteins
FH978_RS00070	COG5645	(Lipo)protein
FH978_RS00085	COG3645	SOS response
FH978_RS00095	COG2188	Transcriptional regulator
FH978_RS00110	COG2149	membrane
FH978_RS00130	COG2610	gluconate transmembrane transporter activity
FH978_RS00135	COG0583	DNA-binding transcription factor activity
FH978_RS00140	COG2814	Major facilitator Superfamily
FH978_RS00165	COG0028	Belongs to the TPP enzyme family
FH978_RS00170	COG0440	acetolactate synthase activity
FH978_RS00175	COG2197	response regulator
FH978_RS00185	COG2271	Major facilitator Superfamily
FH978_RS00240	COG2188	Transcriptional regulator
FH978_RS00265	COG4580	involved in the transport of maltose and maltodextrins
FH978_RS00270	COG1447	Phosphotransferase system cellobiose-specific component IIA
FH978_RS00275	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FH978_RS00275	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FH978_RS00285	COG1609	Transcriptional regulator
FH978_RS00300	COG0583	DNA-binding transcription factor activity
FH978_RS00305	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FH978_RS00310	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FH978_RS00315	COG2828	Protein conserved in bacteria
FH978_RS00330	COG0697	spore germination
FH978_RS00335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FH978_RS00335	COG1263	PTS System
FH978_RS00345	COG2814	Major facilitator Superfamily
FH978_RS00375	COG1309	transcriptional regulator
FH978_RS00385	COG0583	DNA-binding transcription factor activity
FH978_RS00410	COG1464	Belongs to the NlpA lipoprotein family
FH978_RS00425	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FH978_RS00435	COG1064	alcohol dehydrogenase
FH978_RS00475	COG1501	Belongs to the glycosyl hydrolase 31 family
FH978_RS00485	COG1486	melibiose metabolic process
FH978_RS00490	COG1263	PTS System
FH978_RS00490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FH978_RS00495	COG2982	Protein involved in outer membrane biogenesis
FH978_RS00500	COG2233	PERMEase
FH978_RS00505	COG0786	glutamate:sodium symporter activity
FH978_RS00525	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FH978_RS00550	COG3152	Membrane
FH978_RS00560	COG1494	fructose-1,6-bisphosphatase
FH978_RS00565	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FH978_RS00570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FH978_RS00575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FH978_RS00595	COG2860	membrane
FH978_RS00605	COG2169	Transcriptional regulator
FH978_RS00605	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FH978_RS00610	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FH978_RS00615	COG1561	YicC-like family, N-terminal region
FH978_RS00630	COG1131	(ABC) transporter
FH978_RS00675	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FH978_RS00710	COG1519	Transferase
FH978_RS00715	COG1216	Glycosyl transferase, family 2
FH978_RS00720	COG0438	transferase activity, transferring glycosyl groups
FH978_RS00730	COG0859	PFAM glycosyl transferase family 9
FH978_RS00755	COG0859	PFAM glycosyl transferase family 9
FH978_RS00770	COG0156	8-amino-7-oxononanoate synthase activity
FH978_RS00780	COG0463	Glycosyl transferase, family 2
FH978_RS00785	COG2861	carbohydrate metabolic process
FH978_RS00790	COG4942	peptidase
FH978_RS00800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FH978_RS00805	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FH978_RS00825	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FH978_RS00835	COG2186	Transcriptional regulator
FH978_RS00855	COG3722	fumarate hydratase activity
FH978_RS00875	COG1566	PFAM secretion protein HlyD family protein
FH978_RS00880	COG0625	glutathione transferase activity
FH978_RS00890	COG3276	selenocysteine insertion sequence binding
FH978_RS00895	COG1414	Transcriptional regulator
FH978_RS00900	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
FH978_RS00905	COG3977	Valine--pyruvate aminotransferase
FH978_RS00910	COG0366	Alpha amylase catalytic
FH978_RS00915	COG2992	FlgJ-related protein
FH978_RS00920	COG2207	Transcriptional regulator
FH978_RS00920	COG1609	Transcriptional regulator
FH978_RS00925	COG4214	carbohydrate transport
FH978_RS00935	COG4213	ABC transporter substrate-binding protein
FH978_RS00950	COG4682	membrane
FH978_RS00955	COG4682	membrane
FH978_RS00960	COG3274	enterobacterial common antigen metabolic process
FH978_RS00990	COG1278	Cold shock
FH978_RS00995	COG2944	sequence-specific DNA binding
FH978_RS01000	COG2814	Major facilitator Superfamily
FH978_RS01025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FH978_RS01035	COG1609	Transcriptional regulator
FH978_RS01040	COG2885	chlorophyll binding
FH978_RS01045	COG0243	molybdopterin cofactor binding
FH978_RS01050	COG0456	acetyltransferase
FH978_RS01055	COG2818	Glycosylase
FH978_RS01060	COG5571	outer membrane autotransporter
FH978_RS01065	COG2223	nitrite transmembrane transporter activity
FH978_RS01090	COG0747	negative chemotaxis
FH978_RS01095	COG0601	transmembrane transport
FH978_RS01100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FH978_RS01105	COG0444	Belongs to the ABC transporter superfamily
FH978_RS01110	COG4608	Belongs to the ABC transporter superfamily
FH978_RS01125	COG2894	cell division
FH978_RS01135	COG1215	transferase activity, transferring glycosyl groups
FH978_RS01155	COG2194	sulfuric ester hydrolase activity
FH978_RS01185	COG1215	transferase activity, transferring glycosyl groups
FH978_RS01190	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
FH978_RS01195	COG3118	belongs to the thioredoxin family
FH978_RS01195	COG0457	Tetratricopeptide repeat
FH978_RS01200	COG2200	EAL domain
FH978_RS01200	COG2199	diguanylate cyclase activity
FH978_RS01210	COG0612	Peptidase, M16
FH978_RS01225	COG2982	Protein involved in outer membrane biogenesis
FH978_RS01230	COG0477	Major facilitator Superfamily
FH978_RS01235	COG1295	ribonuclease BN
FH978_RS01240	COG0583	DNA-binding transcription factor activity
FH978_RS01245	COG1028	Short-chain dehydrogenase reductase Sdr
FH978_RS01250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FH978_RS01260	COG1454	alcohol dehydrogenase
FH978_RS01270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FH978_RS01275	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FH978_RS01280	COG0671	phosphoesterase, PA-phosphatase related
FH978_RS01300	COG0589	response to stress
FH978_RS01310	COG0306	phosphate transporter
FH978_RS01315	COG2081	HI0933 family
FH978_RS01320	COG2239	Acts as a magnesium transporter
FH978_RS01330	COG1124	(ABC) transporter
FH978_RS01340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FH978_RS01345	COG0601	transmembrane transport
FH978_RS01350	COG0747	negative chemotaxis
FH978_RS01360	COG3479	Phenolic acid decarboxylase
FH978_RS01405	COG0477	Major facilitator Superfamily
FH978_RS01415	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FH978_RS01430	COG3714	YhhN family
FH978_RS01440	COG3776	membrane
FH978_RS01445	COG0742	ribosomal rna small subunit methyltransferase
FH978_RS01455	COG2884	Cell division ATP-binding protein ftsE
FH978_RS01460	COG2177	Part of the ABC transporter FtsEX involved in
FH978_RS01475	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FH978_RS01485	COG0683	leucine binding
FH978_RS01500	COG0683	leucine binding
FH978_RS01505	COG0559	Belongs to the binding-protein-dependent transport system permease family
FH978_RS01555	COG0584	glycerophosphoryl diester phosphodiesterase
FH978_RS01565	COG0405	Gamma-glutamyltransferase
FH978_RS01570	COG1247	-acetyltransferase
FH978_RS01580	COG0673	inositol 2-dehydrogenase activity
FH978_RS01585	COG1741	Belongs to the pirin family
FH978_RS01590	COG1609	Transcriptional regulator
FH978_RS01595	COG3265	gluconokinase activity
FH978_RS01600	COG2610	gluconate transmembrane transporter activity
FH978_RS01610	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FH978_RS01635	COG0058	SHG alpha-glucan phosphorylase activity
FH978_RS01650	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FH978_RS01665	COG1349	DNA-binding transcription factor activity
FH978_RS01675	COG0058	SHG alpha-glucan phosphorylase activity
FH978_RS01680	COG1640	4-alpha-glucanotransferase
FH978_RS01685	COG2610	gluconate transmembrane transporter activity
FH978_RS01695	COG1040	competence protein
FH978_RS01720	COG1918	ferrous iron import across plasma membrane
FH978_RS01725	COG2183	response to ionizing radiation
FH978_RS01730	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FH978_RS01755	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FH978_RS01760	COG1011	Hydrolase
FH978_RS01770	COG0494	nUDIX hydrolase
FH978_RS01775	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FH978_RS01800	COG4796	Type ii and iii secretion system protein
FH978_RS01815	COG3266	domain, Protein
FH978_RS01820	COG0338	D12 class N6 adenine-specific DNA methyltransferase
FH978_RS01825	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FH978_RS01855	COG0402	S-adenosylhomocysteine deaminase activity
FH978_RS01860	COG0738	Major facilitator superfamily
FH978_RS01885	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FH978_RS01890	COG1289	transmembrane transporter activity
FH978_RS01900	COG1765	OsmC-like protein
FH978_RS01915	COG0429	hydrolase of the alpha beta-hydrolase fold
FH978_RS01925	COG0488	(ABC) transporter
FH978_RS01940	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
FH978_RS01945	COG1047	Peptidyl-prolyl cis-trans
FH978_RS01955	COG0545	Peptidyl-prolyl cis-trans isomerase
FH978_RS01960	COG2964	Protein conserved in bacteria
FH978_RS02015	COG0051	transcription antitermination factor activity, RNA binding
FH978_RS02040	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FH978_RS02055	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FH978_RS02120	COG0201	protein transport
FH978_RS02145	COG0202	RNA polymerase activity
FH978_RS02160	COG0789	Transcriptional regulator
FH978_RS02165	COG3036	rescue of stalled ribosome
FH978_RS02195	COG0758	DNA mediated transformation
FH978_RS02205	COG0551	DNA topoisomerase type I activity
FH978_RS02225	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FH978_RS02260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FH978_RS02265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FH978_RS02270	COG1309	transcriptional regulator
FH978_RS02300	COG3924	membrane
FH978_RS02305	COG0439	Biotin carboxylase
FH978_RS02310	COG0511	ligase activity, forming carbon-carbon bonds
FH978_RS02335	COG2199	diguanylate cyclase activity
FH978_RS02335	COG2200	EAL domain
FH978_RS02340	COG1077	Cell shape determining protein MreB Mrl
FH978_RS02350	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FH978_RS02360	COG1530	ribonuclease E activity
FH978_RS02370	COG0312	modulator of DNA gyrase
FH978_RS02375	COG0583	DNA-binding transcription factor activity
FH978_RS02390	COG1289	transmembrane transporter activity
FH978_RS02395	COG2732	(Barnase) inhibitor
FH978_RS02420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FH978_RS02425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FH978_RS02430	COG3105	Protein conserved in bacteria
FH978_RS02435	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FH978_RS02455	COG0625	glutathione transferase activity
FH978_RS02460	COG2969	positive regulation of protein catabolic process
FH978_RS02470	COG0493	'glutamate synthase
FH978_RS02475	COG0070	glutamate synthase
FH978_RS02475	COG0067	glutamate synthase
FH978_RS02475	COG0069	glutamate synthase activity
FH978_RS02480	COG1242	4 iron, 4 sulfur cluster binding
FH978_RS02495	COG1312	Catalyzes the dehydration of D-mannonate
FH978_RS02500	COG5002	protein histidine kinase activity
FH978_RS02500	COG0784	Response regulator, receiver
FH978_RS02500	COG2198	Histidine kinase
FH978_RS02505	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
FH978_RS02510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FH978_RS02515	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FH978_RS02525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FH978_RS02530	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FH978_RS02535	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
FH978_RS02540	COG1137	ATPase activity
FH978_RS02545	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FH978_RS02550	COG3117	lipopolysaccharide transmembrane transporter activity
FH978_RS02555	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FH978_RS02565	COG0530	calcium, potassium:sodium antiporter activity
FH978_RS02575	COG1127	ABC transporter
FH978_RS02580	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FH978_RS02585	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FH978_RS02590	COG2854	intermembrane phospholipid transfer
FH978_RS02595	COG3113	response to antibiotic
FH978_RS02600	COG5007	Belongs to the BolA IbaG family
FH978_RS02610	COG3423	Transcriptional regulator
FH978_RS02615	COG0142	geranyltranstransferase activity
FH978_RS02630	COG0697	spore germination
FH978_RS02640	COG2027	D-alanyl-D-alanine carboxypeptidase
FH978_RS02650	COG1534	Rna-binding protein
FH978_RS02660	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FH978_RS02665	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FH978_RS02675	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FH978_RS02715	COG0195	Participates in both transcription termination and antitermination
FH978_RS02760	COG0814	amino acid
FH978_RS02785	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FH978_RS02830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FH978_RS02835	COG0826	peptidase U32
FH978_RS02840	COG0826	peptidase U32
FH978_RS02845	COG3154	lipid carrier protein
FH978_RS02850	COG3153	acetyltransferase
FH978_RS02865	COG0693	protein deglycase activity
FH978_RS02870	COG0702	epimerase
FH978_RS02875	COG0701	Predicted permease
FH978_RS02880	COG2823	Periplasmic or secreted lipoprotein
FH978_RS02900	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FH978_RS02915	COG1063	alcohol dehydrogenase
FH978_RS02920	COG3775	system Galactitol-specific IIC component
FH978_RS02925	COG3414	Phosphotransferase system galactitol-specific IIB component
FH978_RS02930	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FH978_RS02940	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FH978_RS02940	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FH978_RS02945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FH978_RS02945	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FH978_RS02945	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FH978_RS02950	COG1105	Belongs to the carbohydrate kinase PfkB family
FH978_RS02960	COG1349	DNA-binding transcription factor activity
FH978_RS02965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FH978_RS02970	COG2721	sulfolactate sulfo-lyase activity
FH978_RS02980	COG2271	Major facilitator Superfamily
FH978_RS02990	COG2084	Dehydrogenase
FH978_RS02995	COG1929	Belongs to the glycerate kinase type-1 family
FH978_RS03015	COG1741	Belongs to the pirin family
FH978_RS03020	COG0583	DNA-binding transcription factor activity
FH978_RS03025	COG3152	Membrane
FH978_RS03030	COG0435	Glutathione S-transferase
FH978_RS03035	COG2259	Doxx family
FH978_RS03045	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
FH978_RS03050	COG4575	ribosome binding
FH978_RS03055	COG1422	Protein of unknown function (DUF1090)
FH978_RS03065	COG0586	Pfam SNARE associated Golgi protein
FH978_RS03070	COG2186	Transcriptional regulator
FH978_RS03075	COG2271	Major facilitator Superfamily
FH978_RS03085	COG2721	sulfolactate sulfo-lyase activity
FH978_RS03100	COG0861	Integral membrane protein TerC family
FH978_RS03105	COG0673	inositol 2-dehydrogenase activity
FH978_RS03110	COG1451	nucleotide metabolic process
FH978_RS03180	COG1695	Transcriptional regulator
FH978_RS03185	COG2375	cellular response to nickel ion
FH978_RS03200	COG1461	Dihydroxyacetone kinase
FH978_RS03205	COG2376	Dihydroxyacetone kinase
FH978_RS03275	COG3247	response to pH
FH978_RS03285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FH978_RS03285	COG2198	Histidine kinase
FH978_RS03285	COG2205	protein histidine kinase activity
FH978_RS03285	COG0784	Response regulator, receiver
FH978_RS03290	COG2197	response regulator
FH978_RS03310	COG4974	Belongs to the 'phage' integrase family
FH978_RS03370	COG4695	Portal protein
FH978_RS03530	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FH978_RS03535	COG0358	DNA primase activity
FH978_RS03540	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FH978_RS03600	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FH978_RS03615	COG4991	sh3 domain protein
FH978_RS03620	COG3025	triphosphatase activity
FH978_RS03640	COG2960	long-chain fatty acid transporting porin activity
FH978_RS03655	COG3384	dioxygenase
FH978_RS03660	COG0754	glutathionylspermidine amidase activity
FH978_RS03675	COG0494	nUDIX hydrolase
FH978_RS03680	COG3151	Protein conserved in bacteria
FH978_RS03685	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FH978_RS03690	COG3150	esterase
FH978_RS03700	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
FH978_RS03705	COG2249	NAD(P)H dehydrogenase (quinone) activity
FH978_RS03710	COG0642	Histidine kinase
FH978_RS03720	COG3111	PFAM Bacterial OB fold (BOF) protein
FH978_RS03725	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
FH978_RS03730	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FH978_RS03735	COG0204	Acyl-transferase
FH978_RS03740	COG2132	Multicopper oxidase
FH978_RS03745	COG1032	radical SAM domain protein
FH978_RS03755	COG0656	L-ascorbic acid biosynthetic process
FH978_RS03760	COG1979	alcohol dehydrogenase
FH978_RS03765	COG2207	Transcriptional regulator
FH978_RS03770	COG0586	Pfam SNARE associated Golgi protein
FH978_RS03775	COG0626	cystathionine gamma-synthase activity
FH978_RS03785	COG0848	biopolymer transport protein
FH978_RS03790	COG2211	Major facilitator Superfamily
FH978_RS03815	COG0625	glutathione transferase activity
FH978_RS03825	COG0754	glutathionylspermidine amidase activity
FH978_RS03830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FH978_RS03855	COG0626	cystathionine gamma-synthase activity
FH978_RS03870	COG1811	Na channel or pump
FH978_RS03880	COG1982	Orn Lys Arg decarboxylase major
FH978_RS03885	COG2211	Major facilitator Superfamily
FH978_RS03900	COG1194	a g-specific adenine glycosylase
FH978_RS03910	COG3171	Protein conserved in bacteria
FH978_RS03920	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FH978_RS03935	COG0762	integral membrane protein
FH978_RS03940	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FH978_RS03945	COG2805	Type II/IV secretion system protein
FH978_RS03965	COG0189	ligase activity
FH978_RS03970	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FH978_RS03975	COG2356	endonuclease I
FH978_RS03985	COG2814	Major facilitator Superfamily
FH978_RS04020	COG2146	nitrite reductase [NAD(P)H] activity
FH978_RS04035	COG1028	Short-chain dehydrogenase reductase Sdr
FH978_RS04040	COG1414	Transcriptional regulator
FH978_RS04070	COG1028	Short-chain dehydrogenase reductase Sdr
FH978_RS04075	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
FH978_RS04095	COG0501	Belongs to the peptidase M48B family
FH978_RS04100	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FH978_RS04115	COG0191	fructose-bisphosphate aldolase activity
FH978_RS04120	COG0668	transmembrane transport
FH978_RS04130	COG2968	Membrane
FH978_RS04145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FH978_RS04150	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FH978_RS04170	COG0006	proline dipeptidase activity
FH978_RS04175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FH978_RS04180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FH978_RS04200	COG1028	Short-chain dehydrogenase reductase Sdr
FH978_RS04210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FH978_RS04230	COG2723	6-phospho-beta-galactosidase activity
FH978_RS04235	COG1737	Transcriptional regulator
FH978_RS04245	COG1272	protein, Hemolysin III
FH978_RS04255	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FH978_RS04265	COG0716	FMN binding
FH978_RS04270	COG4974	Belongs to the 'phage' integrase family
FH978_RS04280	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FH978_RS04300	COG4942	peptidase
FH978_RS04310	COG2814	Major facilitator Superfamily
FH978_RS04325	COG0667	Aldo Keto reductase
FH978_RS04370	COG1393	Belongs to the ArsC family
FH978_RS04395	COG1289	transmembrane transporter activity
FH978_RS04410	COG3592	Divergent 4Fe-4S mono-cluster
FH978_RS04415	COG2388	GCN5-related N-acetyl-transferase
FH978_RS04425	COG3539	Fimbrial protein
FH978_RS04430	COG3539	Fimbrial protein
FH978_RS04435	COG3539	Fimbrial protein
FH978_RS04440	COG3188	usher protein
FH978_RS04445	COG3121	Chaperone
FH978_RS04450	COG3539	Fimbrial protein
FH978_RS04460	COG4974	Belongs to the 'phage' integrase family
FH978_RS04465	COG0582	viral genome integration into host DNA
FH978_RS04475	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
FH978_RS04480	COG1846	Transcriptional regulator
FH978_RS04485	COG0697	spore germination
FH978_RS04535	COG0667	Aldo Keto reductase
FH978_RS04540	COG0814	amino acid
FH978_RS04555	COG0183	Belongs to the thiolase family
FH978_RS04570	COG1028	Short-chain dehydrogenase reductase Sdr
FH978_RS04605	COG3842	ATPase activity
FH978_RS04610	COG0395	ABC-type sugar transport system, permease component
FH978_RS04615	COG1175	transmembrane transport
FH978_RS04620	COG1917	Cupin 2, conserved barrel domain protein
FH978_RS04625	COG1794	racemase activity, acting on amino acids and derivatives
FH978_RS04630	COG0583	DNA-binding transcription factor activity
FH978_RS04640	COG1609	Transcriptional regulator
FH978_RS04645	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FH978_RS04650	COG2723	6-phospho-beta-galactosidase activity
FH978_RS04655	COG2186	Transcriptional regulator
FH978_RS04665	COG1609	Transcriptional regulator
FH978_RS04680	COG0667	Aldo Keto reductase
FH978_RS04690	COG0861	Integral membrane protein TerC family
FH978_RS04730	COG4795	General secretion pathway protein
FH978_RS04740	COG4967	type IV pilus modification protein PilV
FH978_RS04745	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FH978_RS04750	COG1025	Belongs to the peptidase M16 family
FH978_RS04760	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FH978_RS04770	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FH978_RS04770	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FH978_RS04780	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FH978_RS04810	COG4656	Part of a membrane complex involved in electron transport
FH978_RS04815	COG1454	alcohol dehydrogenase
FH978_RS04815	COG1012	belongs to the aldehyde dehydrogenase family
FH978_RS04845	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
FH978_RS05010	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
FH978_RS05015	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FH978_RS05020	COG2166	iron-sulfur cluster assembly
FH978_RS05035	COG0583	DNA-binding transcription factor activity
FH978_RS05040	COG2363	Small membrane protein
FH978_RS05050	COG1349	DNA-binding transcription factor activity
FH978_RS05070	COG0738	Major facilitator superfamily
FH978_RS05075	COG0235	Class ii aldolase
FH978_RS05080	COG1454	alcohol dehydrogenase
FH978_RS05095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FH978_RS05110	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FH978_RS05115	COG2011	ABC-type metal ion transport system permease component
FH978_RS05120	COG1464	Belongs to the NlpA lipoprotein family
FH978_RS05130	COG0477	Major facilitator Superfamily
FH978_RS05140	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FH978_RS05145	COG1760	l-serine dehydratase
FH978_RS05150	COG0814	amino acid
FH978_RS05155	COG1611	Belongs to the LOG family
FH978_RS05170	COG3098	single-species biofilm formation
FH978_RS05175	COG0564	pseudouridine synthase activity
FH978_RS05180	COG0716	FMN binding
FH978_RS05185	COG2271	Major facilitator Superfamily
FH978_RS05190	COG4948	Mandelate Racemase Muconate Lactonizing
FH978_RS05195	COG4948	Mandelate Racemase Muconate Lactonizing
FH978_RS05200	COG1929	Belongs to the glycerate kinase type-1 family
FH978_RS05210	COG3437	response regulator, receiver
FH978_RS05210	COG2205	protein histidine kinase activity
FH978_RS05210	COG4999	Histidine kinase
FH978_RS05210	COG3850	Histidine kinase
FH978_RS05220	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FH978_RS05225	COG3956	TIGRFAM MazG family protein
FH978_RS05245	COG0602	queuosine metabolic process
FH978_RS05250	COG0720	synthase
FH978_RS05270	COG2234	aminopeptidase activity
FH978_RS05335	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FH978_RS05360	COG0163	prenyltransferase activity
FH978_RS05365	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FH978_RS05410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FH978_RS05415	COG4558	Periplasmic binding protein
FH978_RS05420	COG3720	iron ion transport
FH978_RS05440	COG0679	Auxin Efflux Carrier
FH978_RS05455	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FH978_RS05460	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FH978_RS05465	COG1121	(ABC) transporter
FH978_RS05470	COG0803	Belongs to the bacterial solute-binding protein 9 family
FH978_RS05475	COG1609	Transcriptional regulator
FH978_RS05480	COG1940	carbohydrate kinase activity
FH978_RS05485	COG1447	Phosphotransferase system cellobiose-specific component IIA
FH978_RS05490	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FH978_RS05495	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FH978_RS05500	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FH978_RS05510	COG4580	involved in the transport of maltose and maltodextrins
FH978_RS05520	COG2723	6-phospho-beta-galactosidase activity
FH978_RS05530	COG0309	Hydrogenase expression formation protein (HypE)
FH978_RS05535	COG0409	Hydrogenase expression formation protein
FH978_RS05540	COG0298	carbon dioxide binding
FH978_RS05545	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FH978_RS05565	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
FH978_RS05570	COG0651	ATP synthesis coupled electron transport
FH978_RS05575	COG0650	Formate hydrogenlyase subunit 4
FH978_RS05580	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
FH978_RS05580	COG3261	NADH dehydrogenase
FH978_RS05585	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FH978_RS05590	COG3260	NADH ubiquinone oxidoreductase 20
FH978_RS05600	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
FH978_RS05610	COG2723	6-phospho-beta-galactosidase activity
FH978_RS05615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FH978_RS05615	COG1263	PTS System
FH978_RS05620	COG1609	Transcriptional regulator
FH978_RS05625	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
FH978_RS05630	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
FH978_RS05635	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
FH978_RS05665	COG1349	DNA-binding transcription factor activity
FH978_RS05670	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
FH978_RS05675	COG1028	Short-chain dehydrogenase reductase Sdr
FH978_RS05685	COG3732	PTS system glucitol sorbitol-specific
FH978_RS05690	COG3730	PTS system glucitol sorbitol-specific
FH978_RS05695	COG2951	lytic endotransglycosylase activity
FH978_RS05705	COG1121	(ABC) transporter
FH978_RS05710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FH978_RS05720	COG1546	Belongs to the CinA family
FH978_RS05745	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
FH978_RS05775	COG2823	Periplasmic or secreted lipoprotein
FH978_RS05780	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FH978_RS05785	COG1238	metal cluster binding
FH978_RS05805	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FH978_RS05810	COG2814	Major facilitator Superfamily
FH978_RS05815	COG1566	PFAM secretion protein HlyD family protein
FH978_RS05820	COG1846	Transcriptional regulator
FH978_RS05830	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FH978_RS05840	COG4176	ABC-type proline glycine betaine transport system permease component
FH978_RS05855	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FH978_RS05865	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FH978_RS05870	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FH978_RS05875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FH978_RS05880	COG4575	ribosome binding
FH978_RS05905	COG2916	Histone family protein nucleoid-structuring protein H-NS
FH978_RS05920	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FH978_RS05925	COG0640	Transcriptional regulator
FH978_RS05935	COG0583	DNA-binding transcription factor activity
FH978_RS05940	COG3284	Transcriptional regulator
FH978_RS05950	COG3539	Fimbrial protein
FH978_RS05955	COG3121	Chaperone
FH978_RS06000	COG3539	Fimbrial protein
FH978_RS06005	COG2197	response regulator
FH978_RS06035	COG0235	Class ii aldolase
FH978_RS06040	COG1126	abc transporter atp-binding protein
FH978_RS06045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FH978_RS06080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FH978_RS06085	COG2207	Transcriptional regulator
FH978_RS06085	COG3708	Transcriptional regulator
FH978_RS06120	COG0582	viral genome integration into host DNA
FH978_RS06190	COG1484	DNA-dependent DNA replication
FH978_RS06200	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
FH978_RS06210	COG0484	heat shock protein binding
FH978_RS06225	COG3772	lysozyme
FH978_RS06270	COG4626	Terminase
FH978_RS06270	COG1802	Transcriptional regulator
FH978_RS06275	COG4695	Portal protein
FH978_RS06280	COG0740	serine-type endopeptidase activity
FH978_RS06420	COG2867	negative regulation of translational initiation
FH978_RS06435	COG0497	DNA recombination
FH978_RS06450	COG4536	flavin adenine dinucleotide binding
FH978_RS06455	COG4137	Cytochrome C assembly protein
FH978_RS06460	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FH978_RS06495	COG2885	chlorophyll binding
FH978_RS06500	COG2199	diguanylate cyclase activity
FH978_RS06510	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FH978_RS06515	COG1605	Chorismate mutase
FH978_RS06515	COG0287	Prephenate dehydrogenase
FH978_RS06525	COG1605	Chorismate mutase
FH978_RS06525	COG0077	Prephenate dehydratase
FH978_RS06535	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FH978_RS06540	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FH978_RS06555	COG0542	response to heat
FH978_RS06580	COG0477	Major facilitator Superfamily
FH978_RS06585	COG5544	Lipoprotein
FH978_RS06590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FH978_RS06600	COG3148	PFAM DTW domain containing protein
FH978_RS06605	COG3118	belongs to the thioredoxin family
FH978_RS06610	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FH978_RS06625	COG0513	Belongs to the DEAD box helicase family
FH978_RS06635	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FH978_RS06650	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
FH978_RS06655	COG3026	antisigma factor binding
FH978_RS06660	COG3086	response to oxidative stress
FH978_RS06670	COG0681	Belongs to the peptidase S26 family
FH978_RS06690	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FH978_RS06700	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FH978_RS06705	COG1737	Transcriptional regulator
FH978_RS06710	COG0560	Phosphoserine phosphatase
FH978_RS06725	COG0047	phosphoribosylformylglycinamidine synthase activity
FH978_RS06725	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FH978_RS06735	COG2205	protein histidine kinase activity
FH978_RS06745	COG2204	response regulator
FH978_RS06750	COG0347	Belongs to the P(II) protein family
FH978_RS06755	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FH978_RS06755	COG1017	nitric oxide dioxygenase activity
FH978_RS06765	COG2259	Doxx family
FH978_RS06770	COG1940	carbohydrate kinase activity
FH978_RS06775	COG0457	Tetratricopeptide repeat
FH978_RS06780	COG2814	Major facilitator Superfamily
FH978_RS06780	COG0477	Major facilitator Superfamily
FH978_RS06785	COG2017	converts alpha-aldose to the beta-anomer
FH978_RS06790	COG2814	Major facilitator Superfamily
FH978_RS06795	COG3711	transcriptional antiterminator
FH978_RS06800	COG3683	transport system, periplasmic component
FH978_RS06805	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
FH978_RS06835	COG0822	iron-sulfur transferase activity
FH978_RS06855	COG0633	Ferredoxin
FH978_RS06860	COG2975	iron-sulfur cluster assembly
FH978_RS06885	COG2373	Large extracellular alpha-helical protein
FH978_RS06890	COG4953	penicillin-binding protein 1C
FH978_RS06925	COG2976	Protein conserved in bacteria
FH978_RS06945	COG1645	bacterial-type flagellum-dependent swarming motility
FH978_RS06955	COG0516	GMP reductase activity
FH978_RS06955	COG0517	IMP dehydrogenase activity
FH978_RS06970	COG0641	radical SAM
FH978_RS07020	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FH978_RS07045	COG2233	PERMEase
FH978_RS07060	COG1393	Belongs to the ArsC family
FH978_RS07065	COG4783	chaperone-mediated protein folding
FH978_RS07070	COG0628	permease
FH978_RS07075	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FH978_RS07080	COG2716	regulation of RNA biosynthetic process
FH978_RS07090	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
FH978_RS07100	COG2321	neutral zinc metallopeptidase
FH978_RS07105	COG1444	tRNA N-acetyltransferase activity
FH978_RS07110	COG0400	carboxylic ester hydrolase activity
FH978_RS07125	COG1393	Belongs to the ArsC family
FH978_RS07135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FH978_RS07145	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
FH978_RS07145	COG0493	'glutamate synthase
FH978_RS07155	COG5342	invasion associated locus B
FH978_RS07165	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FH978_RS07175	COG4810	utilization protein
FH978_RS07265	COG0860	N-Acetylmuramoyl-L-alanine amidase
FH978_RS07285	COG2837	iron assimilation
FH978_RS07295	COG4150	thiosulfate binding
FH978_RS07300	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FH978_RS07305	COG4208	sulfate ABC transporter
FH978_RS07310	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FH978_RS07320	COG4319	ketosteroid isomerase
FH978_RS07355	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FH978_RS07375	COG3530	Putative quorum-sensing-regulated virulence factor
FH978_RS07380	COG0385	Bile acid
FH978_RS07385	COG0583	DNA-binding transcription factor activity
FH978_RS07425	COG3415	Transposase
FH978_RS07440	COG2199	diguanylate cyclase activity
FH978_RS07440	COG2200	EAL domain
FH978_RS07445	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FH978_RS07460	COG0667	Aldo Keto reductase
FH978_RS07465	COG3961	Belongs to the TPP enzyme family
FH978_RS07480	COG3279	Response regulator of the LytR AlgR family
FH978_RS07485	COG3275	phosphorelay sensor kinase activity
FH978_RS07495	COG0436	Aminotransferase
FH978_RS07505	COG2807	transmembrane transport
FH978_RS07510	COG0590	tRNA wobble adenosine to inosine editing
FH978_RS07515	COG0583	DNA-binding transcription factor activity
FH978_RS07535	COG2116	formate transmembrane transporter activity
FH978_RS07540	COG2853	Lipoprotein
FH978_RS07550	COG3691	Protein conserved in bacteria
FH978_RS07565	COG2062	phosphohistidine phosphatase, SixA
FH978_RS07590	COG0730	response to heat
FH978_RS07595	COG3101	peptidyl-lysine hydroxylation
FH978_RS07610	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FH978_RS07630	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FH978_RS07640	COG0586	Pfam SNARE associated Golgi protein
FH978_RS07650	COG0285	dihydrofolate synthase activity
FH978_RS07655	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
FH978_RS07660	COG1286	toxin biosynthetic process
FH978_RS07665	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FH978_RS07670	COG3829	transcription factor binding
FH978_RS07680	COG0531	amino acid
FH978_RS07685	COG3457	Alanine racemase
FH978_RS07690	COG0833	amino acid
FH978_RS07695	COG0163	prenyltransferase activity
FH978_RS07715	COG4160	amino acid transport
FH978_RS07720	COG4598	ABC transporter
FH978_RS07730	COG1090	epimerase
FH978_RS07735	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FH978_RS07740	COG0625	glutathione transferase activity
FH978_RS07745	COG0625	glutathione transferase activity
FH978_RS07750	COG0622	Phosphoesterase
FH978_RS07755	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FH978_RS07760	COG0857	belongs to the CobB CobQ family
FH978_RS07760	COG0280	phosphate acetyltransferase
FH978_RS07780	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FH978_RS07785	COG0490	domain, Protein
FH978_RS07785	COG0471	metal ion transport
FH978_RS07795	COG0436	Aminotransferase
FH978_RS07800	COG0583	DNA-binding transcription factor activity
FH978_RS07850	COG0839	Belongs to the complex I subunit 6 family
FH978_RS07860	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FH978_RS07865	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FH978_RS07880	COG2153	protein acetylation
FH978_RS07885	COG1169	isochorismate synthase
FH978_RS07910	COG0318	PFAM AMP-dependent synthetase and ligase
FH978_RS07920	COG5464	transposase or invertase
FH978_RS07935	COG1414	Transcriptional regulator
FH978_RS07945	COG2271	Major facilitator Superfamily
FH978_RS07970	COG2271	Major facilitator Superfamily
FH978_RS07975	COG0584	glycerophosphoryl diester phosphodiesterase
FH978_RS07980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FH978_RS08005	COG2205	protein histidine kinase activity
FH978_RS08005	COG0784	Response regulator, receiver
FH978_RS08015	COG0642	Histidine kinase
FH978_RS08015	COG2198	Histidine kinase
FH978_RS08030	COG2169	Transcriptional regulator
FH978_RS08030	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FH978_RS08035	COG3145	DNA-N1-methyladenine dioxygenase activity
FH978_RS08040	COG4615	Cyclic peptide transporter
FH978_RS08045	COG2239	Acts as a magnesium transporter
FH978_RS08050	COG0659	secondary active sulfate transmembrane transporter activity
FH978_RS08065	COG0628	permease
FH978_RS08090	COG1349	DNA-binding transcription factor activity
FH978_RS08095	COG0494	nUDIX hydrolase
FH978_RS08115	COG1061	Type III restriction enzyme res subunit
FH978_RS08120	COG1187	pseudouridine synthase activity
FH978_RS08125	COG2814	Major facilitator Superfamily
FH978_RS08135	COG4172	Belongs to the ABC transporter superfamily
FH978_RS08140	COG4239	(ABC) transporter, permease
FH978_RS08145	COG4174	ABC transporter (Permease)
FH978_RS08150	COG4166	transmembrane transport
FH978_RS08155	COG2200	EAL domain
FH978_RS08160	COG0791	NLP P60 protein
FH978_RS08165	COG0671	phosphoesterase, PA-phosphatase related
FH978_RS08175	COG0246	Mannitol dehydrogenase
FH978_RS08180	COG1312	Catalyzes the dehydration of D-mannonate
FH978_RS08200	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FH978_RS08200	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FH978_RS08205	COG1105	Belongs to the carbohydrate kinase PfkB family
FH978_RS08210	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FH978_RS08210	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
FH978_RS08210	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FH978_RS08220	COG2855	membrane
FH978_RS08225	COG0583	DNA-binding transcription factor activity
FH978_RS08230	COG0833	amino acid
FH978_RS08235	COG4771	TonB-dependent receptor
FH978_RS08250	COG2311	Membrane
FH978_RS08265	COG1129	ABC transporter
FH978_RS08275	COG2949	membrane
FH978_RS08285	COG1346	cytolysis
FH978_RS08295	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FH978_RS08300	COG3659	wide pore channel activity
FH978_RS08315	COG2723	6-phospho-beta-galactosidase activity
FH978_RS08320	COG1538	Outer membrane efflux protein
FH978_RS08325	COG0586	Pfam SNARE associated Golgi protein
FH978_RS08335	COG1686	Belongs to the peptidase S11 family
FH978_RS08350	COG0277	FAD linked oxidase domain protein
FH978_RS08355	COG1472	Belongs to the glycosyl hydrolase 3 family
FH978_RS08360	COG1732	Glycine betaine
FH978_RS08365	COG1174	glycine betaine transport
FH978_RS08375	COG1174	glycine betaine transport
FH978_RS08395	COG4807	Protein conserved in bacteria
FH978_RS08415	COG5455	response to cobalt ion
FH978_RS08420	COG0583	DNA-binding transcription factor activity
FH978_RS08425	COG2252	PERMEase
FH978_RS08435	COG0583	DNA-binding transcription factor activity
FH978_RS08450	COG0351	phosphomethylpyrimidine kinase
FH978_RS08455	COG1830	Aldolase
FH978_RS08490	COG1070	Carbohydrate kinase
FH978_RS08500	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FH978_RS08505	COG4948	Mandelate Racemase Muconate Lactonizing
FH978_RS08510	COG0747	negative chemotaxis
FH978_RS08515	COG0601	transmembrane transport
FH978_RS08520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FH978_RS08525	COG0444	Belongs to the ABC transporter superfamily
FH978_RS08530	COG4608	Belongs to the ABC transporter superfamily
FH978_RS08540	COG0826	peptidase U32
FH978_RS08545	COG0745	RESPONSE REGULATOR receiver
FH978_RS08550	COG2205	protein histidine kinase activity
FH978_RS08575	COG1301	dicarboxylic acid transport
FH978_RS08600	COG0443	Heat shock 70 kDa protein
FH978_RS08620	COG2982	Protein involved in outer membrane biogenesis
FH978_RS08625	COG1253	flavin adenine dinucleotide binding
FH978_RS08700	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FH978_RS08755	COG0438	transferase activity, transferring glycosyl groups
FH978_RS08760	COG1215	transferase activity, transferring glycosyl groups
FH978_RS08780	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FH978_RS08810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FH978_RS08815	COG0583	DNA-binding transcription factor activity
FH978_RS08825	COG0531	amino acid
FH978_RS08830	COG0640	Transcriptional regulator
FH978_RS08835	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FH978_RS08840	COG2925	Exonuclease
FH978_RS08855	COG1289	transmembrane transporter activity
FH978_RS08875	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FH978_RS08885	COG1942	4-Oxalocrotonate Tautomerase
FH978_RS08890	COG0583	DNA-binding transcription factor activity
FH978_RS08895	COG0095	Lipoate-protein ligase
FH978_RS08900	COG0477	Major facilitator Superfamily
FH978_RS08915	COG3300	MHYT domain
FH978_RS08915	COG5001	Diguanylate cyclase
FH978_RS08925	COG3615	Tellurite resistance protein tehB
FH978_RS08950	COG3706	GGDEF domain
FH978_RS08990	COG2197	response regulator
FH978_RS09010	COG1250	3-hydroxyacyl-CoA dehydrogenase
FH978_RS09015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FH978_RS09020	COG1960	acyl-CoA dehydrogenase activity
FH978_RS09050	COG0154	amidase activity
FH978_RS09075	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
FH978_RS09145	COG3504	Conjugal transfer protein
FH978_RS09225	COG4771	TonB-dependent receptor
FH978_RS09230	COG1021	2,3-dihydroxybenzoate-AMP ligase
FH978_RS09250	COG3433	isochorismatase activity
FH978_RS09250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FH978_RS09250	COG2226	methyltransferase
FH978_RS09265	COG1132	(ABC) transporter
FH978_RS09270	COG2814	Major facilitator Superfamily
FH978_RS09275	COG1169	isochorismate synthase
FH978_RS09280	COG0582	viral genome integration into host DNA
FH978_RS09300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FH978_RS09305	COG0735	belongs to the Fur family
FH978_RS09315	COG0523	cobalamin synthesis protein
FH978_RS09345	COG0523	cobalamin synthesis protein
FH978_RS09375	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FH978_RS09380	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FH978_RS09385	COG1121	(ABC) transporter
FH978_RS09390	COG0803	Belongs to the bacterial solute-binding protein 9 family
FH978_RS09395	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FH978_RS09405	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FH978_RS09435	COG0803	Belongs to the bacterial solute-binding protein 9 family
FH978_RS09440	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FH978_RS09445	COG1121	(ABC) transporter
FH978_RS09455	COG0582	viral genome integration into host DNA
FH978_RS09465	COG0534	Mate efflux family protein
FH978_RS09475	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FH978_RS09495	COG0604	alcohol dehydrogenase
FH978_RS09500	COG1309	transcriptional regulator
FH978_RS09555	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FH978_RS09570	COG1418	mRNA catabolic process
FH978_RS09575	COG0270	DNA (cytosine-5-)-methyltransferase activity
FH978_RS09580	COG3727	T/G mismatch-specific endonuclease activity
FH978_RS09585	COG0697	spore germination
FH978_RS09620	COG0366	Alpha amylase catalytic
FH978_RS09625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FH978_RS09635	COG0765	amino acid transport
FH978_RS09640	COG1126	abc transporter atp-binding protein
FH978_RS09655	COG2197	response regulator
FH978_RS09690	COG3318	Belongs to the UPF0149 family
FH978_RS09690	COG3012	SEC-C Motif Domain Protein
FH978_RS09705	COG1528	Iron-storage protein
FH978_RS09720	COG0477	Major facilitator Superfamily
FH978_RS09730	COG2211	Major facilitator Superfamily
FH978_RS09740	COG1528	Iron-storage protein
FH978_RS09750	COG1879	ABC-type sugar transport system periplasmic component
FH978_RS09760	COG1172	Belongs to the binding-protein-dependent transport system permease family
FH978_RS09785	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
FH978_RS09795	COG3102	Protein conserved in bacteria
FH978_RS09815	COG3788	relative of glutathione S-transferase, MAPEG superfamily
FH978_RS09820	COG1801	Protein of unknown function DUF72
FH978_RS09825	COG1335	isochorismatase
FH978_RS09835	COG0494	nUDIX hydrolase
FH978_RS09860	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FH978_RS09870	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
FH978_RS09875	COG0739	heme binding
FH978_RS09880	COG1560	Kdo2-lipid A biosynthetic process
FH978_RS09890	COG1737	Transcriptional regulator
FH978_RS09905	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FH978_RS09910	COG0129	dihydroxy-acid dehydratase activity
FH978_RS09915	COG0800	Aldolase
FH978_RS09925	COG3141	response to X-ray
FH978_RS09930	COG2979	Protein of unknown function (DUF533)
FH978_RS09935	COG1770	oligopeptidase
FH978_RS09940	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FH978_RS09950	COG2372	response to copper ion
FH978_RS09955	COG1276	copper resistance
FH978_RS09975	COG2990	Protein conserved in bacteria
FH978_RS10000	COG3008	intermembrane lipid transfer
FH978_RS10005	COG2995	paraquat-inducible protein a
FH978_RS10010	COG1956	GAF domain-containing protein
FH978_RS10030	COG2814	Major facilitator Superfamily
FH978_RS10035	COG1414	Transcriptional regulator
FH978_RS10080	COG2226	methyltransferase
FH978_RS10095	COG3716	PTS system mannose fructose sorbose family IID component
FH978_RS10100	COG3715	PTS system
FH978_RS10105	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FH978_RS10105	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FH978_RS10110	COG1253	flavin adenine dinucleotide binding
FH978_RS10115	COG2200	EAL domain
FH978_RS10120	COG1760	l-serine dehydratase
FH978_RS10140	COG0251	oxidation-reduction process
FH978_RS10155	COG1214	PFAM Peptidase M22, glycoprotease
FH978_RS10160	COG3065	identical protein binding
FH978_RS10170	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FH978_RS10180	COG2894	cell division
FH978_RS10195	COG0179	Fumarylacetoacetate (FAA) hydrolase
FH978_RS10225	COG2719	SpoVR family
FH978_RS10245	COG1619	proteins homologs of microcin C7 resistance protein MccF
FH978_RS10255	COG4774	siderophore transport
FH978_RS10270	COG2308	Evidence 4 Homologs of previously reported genes of
FH978_RS10310	COG0583	DNA-binding transcription factor activity
FH978_RS10315	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FH978_RS10330	COG1882	Formate acetyltransferase
FH978_RS10360	COG0583	DNA-binding transcription factor activity
FH978_RS10390	COG0583	DNA-binding transcription factor activity
FH978_RS10405	COG3122	Protein conserved in bacteria
FH978_RS10520	COG0012	GTP binding
FH978_RS10540	COG0659	secondary active sulfate transmembrane transporter activity
FH978_RS10570	COG2890	protein-(glutamine-N5) methyltransferase activity
FH978_RS10590	COG0387	Pfam Sodium calcium exchanger
FH978_RS10595	COG4572	Cation transport regulator
FH978_RS10600	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
FH978_RS10610	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FH978_RS10615	COG3707	response regulator
FH978_RS10620	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FH978_RS10630	COG1116	anion transmembrane transporter activity
FH978_RS10635	COG2146	nitrite reductase [NAD(P)H] activity
FH978_RS10635	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FH978_RS10640	COG0243	molybdopterin cofactor binding
FH978_RS10645	COG4932	domain protein
FH978_RS10650	COG2197	response regulator
FH978_RS10655	COG3850	Histidine kinase
FH978_RS10660	COG2223	nitrite transmembrane transporter activity
FH978_RS10665	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
FH978_RS10670	COG1140	nitrate reductase beta subunit
FH978_RS10675	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
FH978_RS10680	COG2181	nitrate reductase activity
FH978_RS10690	COG1522	sequence-specific DNA binding
FH978_RS10720	COG0788	formyltetrahydrofolate deformylase activity
FH978_RS10730	COG1752	Esterase of the alpha-beta hydrolase superfamily
FH978_RS10735	COG0745	RESPONSE REGULATOR receiver
FH978_RS10740	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FH978_RS10745	COG2916	Histone family protein nucleoid-structuring protein H-NS
FH978_RS10750	COG1435	thymidine kinase activity
FH978_RS10755	COG1454	alcohol dehydrogenase
FH978_RS10755	COG1012	belongs to the aldehyde dehydrogenase family
FH978_RS10765	COG2095	MarC family integral membrane protein
FH978_RS10770	COG4166	transmembrane transport
FH978_RS10775	COG0601	transmembrane transport
FH978_RS10780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FH978_RS10785	COG0444	Belongs to the ABC transporter superfamily
FH978_RS10795	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FH978_RS10815	COG2353	YceI-like domain
FH978_RS10825	COG2350	Protein conserved in bacteria
FH978_RS10880	COG3001	Fructosamine kinase
FH978_RS10890	COG1105	Belongs to the carbohydrate kinase PfkB family
FH978_RS10895	COG3137	Salt-induced outer membrane protein
FH978_RS10980	COG0386	Belongs to the glutathione peroxidase family
FH978_RS10990	COG0791	NLP P60 protein
FH978_RS11000	COG4256	Hemin uptake protein
FH978_RS11005	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FH978_RS11015	COG0574	Belongs to the PEP-utilizing enzyme family
FH978_RS11015	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FH978_RS11025	COG0628	permease
FH978_RS11030	COG0277	FAD linked oxidase domain protein
FH978_RS11030	COG0247	lactate metabolic process
FH978_RS11035	COG2050	protein possibly involved in aromatic compounds catabolism
FH978_RS11040	COG2261	transglycosylase associated protein
FH978_RS11070	COG1120	ATPase activity
FH978_RS11075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FH978_RS11085	COG0583	DNA-binding transcription factor activity
FH978_RS11110	COG1304	FMN binding
FH978_RS11115	COG1309	transcriptional regulator
FH978_RS11130	COG0316	Belongs to the HesB IscA family
FH978_RS11135	COG0719	Fe-S assembly protein
FH978_RS11140	COG0396	ATPase activity
FH978_RS11145	COG0719	Fe-S assembly protein
FH978_RS11160	COG1376	ErfK ybiS ycfS ynhG family protein
FH978_RS11185	COG1309	transcriptional regulator
FH978_RS11190	COG3185	4-Hydroxyphenylpyruvate dioxygenase
FH978_RS11190	COG1082	Xylose isomerase domain protein TIM barrel
FH978_RS11195	COG2271	Major facilitator Superfamily
FH978_RS11200	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FH978_RS11210	COG1120	ATPase activity
FH978_RS11215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FH978_RS11220	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FH978_RS11225	COG1414	Transcriptional regulator
FH978_RS11260	COG2814	Major facilitator Superfamily
FH978_RS11280	COG0583	DNA-binding transcription factor activity
FH978_RS11285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FH978_RS11305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FH978_RS11310	COG1116	anion transmembrane transporter activity
FH978_RS11320	COG1120	ATPase activity
FH978_RS11330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FH978_RS11350	COG0765	amino acid transport
FH978_RS11355	COG1126	abc transporter atp-binding protein
FH978_RS11385	COG1473	amidohydrolase
FH978_RS11390	COG3383	formate dehydrogenase (NAD+) activity
FH978_RS11395	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
FH978_RS11410	COG1175	transmembrane transport
FH978_RS11440	COG4133	protoheme IX ABC transporter activity
FH978_RS11445	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FH978_RS11450	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FH978_RS11465	COG1138	Cytochrome C-type biogenesis protein
FH978_RS11470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FH978_RS11475	COG4235	cytochrome complex assembly
FH978_RS11475	COG3088	subunit of a heme lyase
FH978_RS11525	COG1028	Short-chain dehydrogenase reductase Sdr
FH978_RS11530	COG2610	gluconate transmembrane transporter activity
FH978_RS11535	COG1250	3-hydroxyacyl-CoA dehydrogenase
FH978_RS11580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FH978_RS11605	COG0402	S-adenosylhomocysteine deaminase activity
FH978_RS11660	COG4608	Belongs to the ABC transporter superfamily
FH978_RS11665	COG0444	Belongs to the ABC transporter superfamily
FH978_RS11690	COG0346	lactoylglutathione lyase activity
FH978_RS11695	COG1349	DNA-binding transcription factor activity
FH978_RS11780	COG0307	riboflavin synthase, alpha
FH978_RS11785	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FH978_RS11790	COG2814	Major facilitator Superfamily
FH978_RS11795	COG0583	DNA-binding transcription factor activity
FH978_RS11810	COG2814	Major facilitator Superfamily
FH978_RS11825	COG0791	NLP P60 protein
FH978_RS11830	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FH978_RS11840	COG0346	lactoylglutathione lyase activity
FH978_RS11850	COG1309	transcriptional regulator
FH978_RS11855	COG3313	Fe-S protein
FH978_RS11860	COG4989	oxidoreductase activity
FH978_RS11865	COG2032	superoxide dismutase activity
FH978_RS11870	COG1289	transmembrane transporter activity
FH978_RS11890	COG3706	GGDEF domain
FH978_RS11905	COG3895	Periplasmic Protein
FH978_RS11920	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FH978_RS11925	COG0625	glutathione transferase activity
FH978_RS11940	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FH978_RS11950	COG4659	FMN binding
FH978_RS11985	COG2723	6-phospho-beta-galactosidase activity
FH978_RS11995	COG0673	inositol 2-dehydrogenase activity
FH978_RS12005	COG2814	Major facilitator Superfamily
FH978_RS12025	COG3038	cytochrome b561
FH978_RS12045	COG0583	DNA-binding transcription factor activity
FH978_RS12050	COG3485	protocatechuate 3,4-dioxygenase
FH978_RS12055	COG3485	protocatechuate 3,4-dioxygenase
FH978_RS12060	COG5383	Protein conserved in bacteria
FH978_RS12065	COG2272	Belongs to the type-B carboxylesterase lipase family
FH978_RS12080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FH978_RS12085	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FH978_RS12090	COG1275	C4-dicarboxylate transporter malic acid transport protein
FH978_RS12095	COG0500	methyltransferase
FH978_RS12110	COG2207	Transcriptional regulator
FH978_RS12110	COG3708	Transcriptional regulator
FH978_RS12115	COG3135	benzoate transporter
FH978_RS12120	COG1396	sequence-specific DNA binding
FH978_RS12130	COG0826	peptidase U32
FH978_RS12150	COG1294	oxidase, subunit
FH978_RS12155	COG1271	oxidase subunit
FH978_RS12165	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FH978_RS12170	COG3842	ATPase activity
FH978_RS12175	COG1176	ABC-type spermidine putrescine transport system, permease component I
FH978_RS12180	COG1177	transmembrane transport
FH978_RS12185	COG1012	belongs to the aldehyde dehydrogenase family
FH978_RS12220	COG1012	belongs to the aldehyde dehydrogenase family
FH978_RS12225	COG0747	negative chemotaxis
FH978_RS12235	COG3238	Protein conserved in bacteria
FH978_RS12240	COG1247	-acetyltransferase
FH978_RS12265	COG3691	Protein conserved in bacteria
FH978_RS12270	COG1228	amidohydrolase
FH978_RS12275	COG4772	TonB-dependent receptor
FH978_RS12305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FH978_RS12310	COG1473	amidohydrolase
FH978_RS12315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FH978_RS12320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FH978_RS12330	COG0765	amino acid transport
FH978_RS12335	COG1126	abc transporter atp-binding protein
FH978_RS12345	COG0625	glutathione transferase activity
FH978_RS12375	COG2211	Major facilitator Superfamily
FH978_RS12390	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FH978_RS12395	COG3842	ATPase activity
FH978_RS12400	COG1840	ABC-type Fe3 transport system, periplasmic component
FH978_RS12405	COG1178	ABC-type Fe3 transport system permease component
FH978_RS12410	COG2162	N-hydroxyarylamine O-acetyltransferase activity
FH978_RS12415	COG2181	nitrate reductase activity
FH978_RS12425	COG1140	nitrate reductase beta subunit
FH978_RS12430	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
FH978_RS12450	COG1414	Transcriptional regulator
FH978_RS12460	COG4829	muconolactone delta-isomerase
FH978_RS12465	COG3485	protocatechuate 3,4-dioxygenase
FH978_RS12475	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
FH978_RS12500	COG0437	4 iron, 4 sulfur cluster binding
FH978_RS12505	COG2864	formate dehydrogenase
FH978_RS12520	COG2326	polyphosphate kinase activity
FH978_RS12530	COG2814	Major facilitator Superfamily
FH978_RS12540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FH978_RS12550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FH978_RS12560	COG0747	negative chemotaxis
FH978_RS12565	COG1064	alcohol dehydrogenase
FH978_RS12580	COG0488	(ABC) transporter
FH978_RS12615	COG1028	Short-chain dehydrogenase reductase Sdr
FH978_RS12620	COG3729	General stress protein
FH978_RS12640	COG3685	Protein conserved in bacteria
FH978_RS12650	COG0366	Alpha amylase catalytic
FH978_RS12660	COG2323	membrane
FH978_RS12670	COG3111	PFAM Bacterial OB fold (BOF) protein
FH978_RS12675	COG1764	response to oxidative stress
FH978_RS12700	COG3781	membrane
FH978_RS12705	COG0243	molybdopterin cofactor binding
FH978_RS12710	COG0583	DNA-binding transcription factor activity
FH978_RS12715	COG1447	Phosphotransferase system cellobiose-specific component IIA
FH978_RS12720	COG2814	Major facilitator Superfamily
FH978_RS12745	COG0583	DNA-binding transcription factor activity
FH978_RS12765	COG0519	Catalyzes the synthesis of GMP from XMP
FH978_RS12765	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FH978_RS12805	COG0596	Alpha beta hydrolase
FH978_RS12830	COG0076	glutamate decarboxylase activity
FH978_RS12835	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FH978_RS12840	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FH978_RS12845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FH978_RS12850	COG1116	anion transmembrane transporter activity
FH978_RS12855	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FH978_RS12865	COG0673	inositol 2-dehydrogenase activity
FH978_RS12880	COG3706	GGDEF domain
FH978_RS12885	COG0402	S-adenosylhomocysteine deaminase activity
FH978_RS12890	COG1953	Uracil, thiamine, allantoin
FH978_RS12935	COG1335	isochorismatase
FH978_RS12955	COG2207	Transcriptional regulator
FH978_RS12975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FH978_RS13040	COG0765	amino acid transport
FH978_RS13050	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FH978_RS13065	COG0583	DNA-binding transcription factor activity
FH978_RS13075	COG1902	pentaerythritol trinitrate reductase activity
FH978_RS13080	COG4529	Protein conserved in bacteria
FH978_RS13085	COG0477	Major facilitator Superfamily
FH978_RS13115	COG2223	nitrite transmembrane transporter activity
FH978_RS13125	COG1609	Transcriptional regulator
FH978_RS13140	COG3037	sugar-specific permease SgaT UlaA
FH978_RS13145	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FH978_RS13155	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FH978_RS13160	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FH978_RS13160	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
FH978_RS13160	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FH978_RS13175	COG0583	DNA-binding transcription factor activity
FH978_RS13180	COG0583	DNA-binding transcription factor activity
FH978_RS13185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FH978_RS13195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FH978_RS13210	COG1172	Belongs to the binding-protein-dependent transport system permease family
FH978_RS13220	COG1609	Transcriptional regulator
FH978_RS13250	COG1652	LysM domain
FH978_RS13275	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
FH978_RS13275	COG0456	acetyltransferase
FH978_RS13290	COG0667	Aldo Keto reductase
FH978_RS13295	COG3386	PFAM SMP-30 Gluconolaconase
FH978_RS13300	COG0667	Aldo Keto reductase
FH978_RS13320	COG4977	sequence-specific DNA binding
FH978_RS13325	COG1349	DNA-binding transcription factor activity
FH978_RS13340	COG1349	DNA-binding transcription factor activity
FH978_RS13345	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FH978_RS13350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FH978_RS13355	COG0738	Major facilitator superfamily
FH978_RS13400	COG1929	Belongs to the glycerate kinase type-1 family
FH978_RS13405	COG3835	regulator
FH978_RS13425	COG2186	Transcriptional regulator
FH978_RS13430	COG1263	PTS System
FH978_RS13430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FH978_RS13440	COG2814	Major facilitator Superfamily
FH978_RS13445	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FH978_RS13445	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FH978_RS13455	COG2819	hydrolase of the alpha beta superfamily
FH978_RS13460	COG3300	MHYT domain
FH978_RS13460	COG5001	Diguanylate cyclase
FH978_RS13510	COG1649	PFAM Uncharacterised BCR, COG1649
FH978_RS13515	COG3550	peptidyl-serine autophosphorylation
FH978_RS13520	COG1396	sequence-specific DNA binding
FH978_RS13525	COG2351	hydroxyisourate hydrolase activity
FH978_RS13530	COG3648	Uricase
FH978_RS13530	COG3195	allantoin biosynthetic process
FH978_RS13535	COG2233	PERMEase
FH978_RS13565	COG2207	Transcriptional regulator
FH978_RS13580	COG4628	conserved protein (DUF2132)
FH978_RS13600	COG2011	ABC-type metal ion transport system permease component
FH978_RS13605	COG2070	2-Nitropropane dioxygenase
FH978_RS13615	COG0477	Major facilitator Superfamily
FH978_RS13695	COG2199	diguanylate cyclase activity
FH978_RS13710	COG1012	belongs to the aldehyde dehydrogenase family
FH978_RS13715	COG0583	DNA-binding transcription factor activity
FH978_RS13725	COG0039	L-malate dehydrogenase activity
FH978_RS13730	COG1349	DNA-binding transcription factor activity
FH978_RS13735	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FH978_RS13740	COG3395	kinase activity
FH978_RS13750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FH978_RS13755	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FH978_RS13760	COG2271	Major facilitator Superfamily
FH978_RS13795	COG0697	spore germination
FH978_RS13830	COG0683	leucine binding
FH978_RS13835	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FH978_RS13870	COG2223	nitrite transmembrane transporter activity
FH978_RS13875	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FH978_RS13890	COG1349	DNA-binding transcription factor activity
FH978_RS13900	COG2084	Dehydrogenase
FH978_RS13910	COG0235	Class ii aldolase
FH978_RS13915	COG3622	Belongs to the hyi family
FH978_RS13920	COG2610	gluconate transmembrane transporter activity
FH978_RS13925	COG3708	Transcriptional regulator
FH978_RS13925	COG2207	Transcriptional regulator
FH978_RS13945	COG2200	EAL domain
FH978_RS13950	COG1546	Belongs to the CinA family
FH978_RS13970	COG2197	response regulator
FH978_RS14000	COG4221	oxidoreductase activity
FH978_RS14005	COG1802	Transcriptional regulator
FH978_RS14010	COG0589	response to stress
FH978_RS14015	COG0246	Mannitol dehydrogenase
FH978_RS14020	COG2271	Major facilitator Superfamily
FH978_RS14035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FH978_RS14050	COG0243	molybdopterin cofactor binding
FH978_RS14055	COG0437	4 iron, 4 sulfur cluster binding
FH978_RS14060	COG3302	dmso reductase anchor subunit
FH978_RS14075	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FH978_RS14080	COG1940	carbohydrate kinase activity
FH978_RS14095	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
FH978_RS14105	COG3591	Belongs to the peptidase S1B family
FH978_RS14125	COG0628	permease
FH978_RS14155	COG0679	Auxin Efflux Carrier
FH978_RS14165	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FH978_RS14190	COG3290	protein histidine kinase activity
FH978_RS14195	COG4565	transcriptional regulatory protein
FH978_RS14215	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
FH978_RS14215	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FH978_RS14230	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FH978_RS14235	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FH978_RS14245	COG0183	Belongs to the thiolase family
FH978_RS14250	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FH978_RS14260	COG1414	Transcriptional regulator
FH978_RS14265	COG2840	Smr protein MutS2
FH978_RS14270	COG0583	DNA-binding transcription factor activity
FH978_RS14280	COG1473	amidohydrolase
FH978_RS14285	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FH978_RS14300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FH978_RS14315	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FH978_RS14320	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FH978_RS14350	COG3136	membrane protein required for alginate biosynthesis
FH978_RS14355	COG0745	RESPONSE REGULATOR receiver
FH978_RS14365	COG2205	protein histidine kinase activity
FH978_RS14375	COG0114	fumarate hydratase activity
FH978_RS14380	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FH978_RS14380	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
FH978_RS14385	COG1482	cell wall glycoprotein biosynthetic process
FH978_RS14390	COG5339	Protein conserved in bacteria
FH978_RS14395	COG1609	Transcriptional regulator
FH978_RS14400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FH978_RS14400	COG1263	PTS System
FH978_RS14405	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FH978_RS14430	COG2391	methyltransferase activity
FH978_RS14435	COG0425	Belongs to the sulfur carrier protein TusA family
FH978_RS14440	COG5562	phage envelope protein
FH978_RS14445	COG0401	homolog of Blt101
FH978_RS14450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FH978_RS14455	COG1012	belongs to the aldehyde dehydrogenase family
FH978_RS14460	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FH978_RS14470	COG1113	amino acid transport
FH978_RS14475	COG2988	succinylglutamate desuccinylase activity
FH978_RS14480	COG3724	N-succinylarginine dihydrolase activity
FH978_RS14485	COG1012	belongs to the aldehyde dehydrogenase family
FH978_RS14490	COG3138	arginine N-succinyltransferase
FH978_RS14495	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FH978_RS14500	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FH978_RS14505	COG0667	Aldo Keto reductase
FH978_RS14535	COG4122	O-methyltransferase activity
FH978_RS14555	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FH978_RS14560	COG3327	negative regulation of DNA-templated transcription, initiation
FH978_RS14565	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
FH978_RS14570	COG0183	Belongs to the thiolase family
FH978_RS14575	COG2050	protein possibly involved in aromatic compounds catabolism
FH978_RS14580	COG1250	3-hydroxyacyl-CoA dehydrogenase
FH978_RS14585	COG1024	Enoyl-CoA hydratase
FH978_RS14590	COG1024	Enoyl-CoA hydratase
FH978_RS14595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FH978_RS14600	COG2151	metal-sulfur cluster biosynthetic enzyme
FH978_RS14605	COG3396	Phenylacetate-CoA oxygenase
FH978_RS14610	COG3460	Phenylacetate-CoA oxygenase
FH978_RS14615	COG3396	Phenylacetate-CoA oxygenase
FH978_RS14620	COG2030	dehydratase
FH978_RS14620	COG1012	belongs to the aldehyde dehydrogenase family
FH978_RS14655	COG2072	flavoprotein involved in K transport
FH978_RS14660	COG0583	DNA-binding transcription factor activity
FH978_RS14675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FH978_RS14700	COG3784	Protein of unknown function (DUF1318)
FH978_RS14710	COG2911	Protein conserved in bacteria
FH978_RS14715	COG0586	Pfam SNARE associated Golgi protein
FH978_RS14720	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FH978_RS14725	COG3187	Heat shock protein
FH978_RS14730	COG3042	response to heat
FH978_RS14745	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FH978_RS14755	COG0589	response to stress
FH978_RS14765	COG0513	Belongs to the DEAD box helicase family
FH978_RS14780	COG1349	DNA-binding transcription factor activity
FH978_RS14785	COG0673	inositol 2-dehydrogenase activity
FH978_RS14815	COG1448	Aminotransferase
FH978_RS14820	COG2011	ABC-type metal ion transport system permease component
FH978_RS14840	COG0604	alcohol dehydrogenase
FH978_RS14865	COG0583	DNA-binding transcription factor activity
FH978_RS14885	COG1028	Short-chain dehydrogenase reductase Sdr
FH978_RS14890	COG1309	transcriptional regulator
FH978_RS14895	COG1028	Short-chain dehydrogenase reductase Sdr
FH978_RS14980	COG2885	chlorophyll binding
FH978_RS15005	COG0693	protein deglycase activity
FH978_RS15010	COG1078	dGTPase activity
FH978_RS15020	COG0583	DNA-binding transcription factor activity
FH978_RS15040	COG0656	L-ascorbic acid biosynthetic process
FH978_RS15075	COG2866	Carboxypeptidase
FH978_RS15080	COG4948	Mandelate Racemase Muconate Lactonizing
FH978_RS15085	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
FH978_RS15090	COG3180	Ammonia monooxygenase
FH978_RS15100	COG1486	melibiose metabolic process
FH978_RS15105	COG0583	DNA-binding transcription factor activity
FH978_RS15115	COG3106	COG3106 Predicted ATPase
FH978_RS15125	COG1983	PspC domain protein
FH978_RS15135	COG1842	Phage shock protein A
FH978_RS15140	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
FH978_RS15150	COG1473	amidohydrolase
FH978_RS15165	COG0702	epimerase
FH978_RS15180	COG4171	peptide transport system, permease
FH978_RS15195	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FH978_RS15205	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FH978_RS15225	COG1349	DNA-binding transcription factor activity
FH978_RS15235	COG0023	Translation Initiation Factor
FH978_RS15245	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FH978_RS15250	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
FH978_RS15255	COG0671	phosphoesterase, PA-phosphatase related
FH978_RS15265	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FH978_RS15290	COG0616	signal peptide processing
FH978_RS15300	COG1028	Short-chain dehydrogenase reductase Sdr
FH978_RS15305	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
FH978_RS15325	COG0009	L-threonylcarbamoyladenylate synthase
FH978_RS15335	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FH978_RS15340	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FH978_RS15340	COG0512	Glutamine amidotransferase of anthranilate synthase
FH978_RS15345	COG0134	indole-3-glycerol-phosphate synthase activity
FH978_RS15345	COG0135	phosphoribosylanthranilate isomerase activity
FH978_RS15380	COG4774	siderophore transport
FH978_RS15395	COG0727	PFAM Uncharacterised protein family (UPF0153)
FH978_RS15425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FH978_RS15430	COG1028	Short-chain dehydrogenase reductase Sdr
FH978_RS15435	COG1988	membrane-bound metal-dependent
FH978_RS15440	COG1823	symporter activity
FH978_RS15450	COG0753	catalase activity
FH978_RS15460	COG1486	melibiose metabolic process
FH978_RS15465	COG1917	Cupin 2, conserved barrel domain protein
FH978_RS15465	COG2169	Transcriptional regulator
FH978_RS15470	COG1447	Phosphotransferase system cellobiose-specific component IIA
FH978_RS15475	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FH978_RS15480	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FH978_RS15485	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FH978_RS15495	COG0322	excinuclease ABC activity
FH978_RS15500	COG3678	ATP-independent chaperone mediated protein folding
FH978_RS15510	COG3724	N-succinylarginine dihydrolase activity
FH978_RS15520	COG3138	arginine N-succinyltransferase
FH978_RS15530	COG0708	Exodeoxyribonuclease III
FH978_RS15535	COG0398	Pfam SNARE associated Golgi protein
FH978_RS15540	COG0398	Pfam SNARE associated Golgi protein
FH978_RS15545	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FH978_RS15550	COG4134	Bacterial extracellular solute-binding protein
FH978_RS15555	COG4135	transport system, permease component
FH978_RS15560	COG4136	ATPase activity
FH978_RS15565	COG2897	thiosulfate sulfurtransferase activity
FH978_RS15570	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FH978_RS15575	COG0494	nUDIX hydrolase
FH978_RS15580	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FH978_RS15585	COG3321	synthase
FH978_RS15585	COG0604	alcohol dehydrogenase
FH978_RS15585	COG1028	Short-chain dehydrogenase reductase Sdr
FH978_RS15590	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FH978_RS15595	COG0709	Synthesizes selenophosphate from selenide and ATP
FH978_RS15615	COG0778	Nitroreductase
FH978_RS15620	COG0616	signal peptide processing
FH978_RS15630	COG1335	isochorismatase
FH978_RS15645	COG3139	Protein of unknown function (DUF1315)
FH978_RS15665	COG0656	L-ascorbic acid biosynthetic process
FH978_RS15675	COG2766	serine protein kinase
FH978_RS15690	COG0386	Belongs to the glutathione peroxidase family
FH978_RS15710	COG1028	Short-chain dehydrogenase reductase Sdr
FH978_RS15715	COG0583	DNA-binding transcription factor activity
FH978_RS15720	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FH978_RS15725	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FH978_RS15735	COG0859	PFAM glycosyl transferase family 9
FH978_RS15740	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FH978_RS15750	COG2207	Transcriptional regulator
FH978_RS15755	COG2807	transmembrane transport
FH978_RS15760	COG0504	CTP synthase activity
FH978_RS15765	COG1683	Conserved Protein
FH978_RS15770	COG3189	MarR family transcriptional regulator
FH978_RS15775	COG3042	response to heat
FH978_RS15780	COG2203	Gaf domain
FH978_RS15780	COG2199	diguanylate cyclase activity
FH978_RS15800	COG3182	Iron-regulated membrane protein
FH978_RS15810	COG1560	Kdo2-lipid A biosynthetic process
FH978_RS15820	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FH978_RS15825	COG3706	GGDEF domain
FH978_RS15830	COG0583	DNA-binding transcription factor activity
FH978_RS15835	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FH978_RS15860	COG1294	oxidase, subunit
FH978_RS15865	COG1271	oxidase subunit
FH978_RS15870	COG3546	catalase activity
FH978_RS15875	COG3685	Protein conserved in bacteria
FH978_RS15880	COG3685	Protein conserved in bacteria
FH978_RS15885	COG3729	General stress protein
FH978_RS15895	COG3813	Protein conserved in bacteria
FH978_RS15915	COG0640	Transcriptional regulator
FH978_RS15920	COG0538	isocitrate dehydrogenase activity
FH978_RS15930	COG5001	Diguanylate cyclase
FH978_RS15930	COG3300	MHYT domain
FH978_RS15935	COG3706	GGDEF domain
FH978_RS16040	COG4626	Terminase
FH978_RS16040	COG1802	Transcriptional regulator
FH978_RS16160	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FH978_RS16170	COG0582	viral genome integration into host DNA
FH978_RS16175	COG0538	isocitrate dehydrogenase activity
FH978_RS16180	COG1187	pseudouridine synthase activity
FH978_RS16200	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FH978_RS16225	COG2850	peptidyl-arginine hydroxylation
FH978_RS16230	COG1943	Transposase
FH978_RS16255	COG1177	transmembrane transport
FH978_RS16270	COG0318	PFAM AMP-dependent synthetase and ligase
FH978_RS16275	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FH978_RS16280	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FH978_RS16285	COG0698	ribose 5-phosphate isomerase
FH978_RS16300	COG3395	kinase activity
FH978_RS16315	COG2390	Transcriptional regulator
FH978_RS16325	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FH978_RS16335	COG4591	ABC-type transport system involved in lipoprotein release permease component
FH978_RS16345	COG4591	ABC-type transport system involved in lipoprotein release permease component
FH978_RS16355	COG1376	ErfK ybiS ycfS ynhG family protein
FH978_RS16355	COG1388	LysM domain
FH978_RS16365	COG1309	transcriptional regulator
FH978_RS16375	COG3134	Outer membrane lipoprotein
FH978_RS16380	COG1252	NADH dehydrogenase
FH978_RS16405	COG5633	Lipoprotein
FH978_RS16410	COG0537	adenosine 5'-monophosphoramidase activity
FH978_RS16435	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FH978_RS16440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FH978_RS16445	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FH978_RS16460	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FH978_RS16480	COG1399	metal-binding, possibly nucleic acid-binding protein
FH978_RS16495	COG1530	ribonuclease E activity
FH978_RS16500	COG0583	DNA-binding transcription factor activity
FH978_RS16505	COG2814	Major facilitator Superfamily
FH978_RS16525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FH978_RS16575	COG1560	Kdo2-lipid A biosynthetic process
FH978_RS16590	COG5645	(Lipo)protein
FH978_RS16625	COG3381	protein complex oligomerization
FH978_RS16650	COG0583	DNA-binding transcription factor activity
FH978_RS16660	COG1335	isochorismatase
FH978_RS16680	COG1702	phosphate starvation-inducible protein PhoH
FH978_RS16710	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FH978_RS16725	COG1309	transcriptional regulator
FH978_RS16760	COG2233	PERMEase
FH978_RS16770	COG3729	General stress protein
FH978_RS16795	COG1028	Short-chain dehydrogenase reductase Sdr
FH978_RS16810	COG0531	amino acid
FH978_RS16820	COG0174	glutamine synthetase
FH978_RS16825	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FH978_RS16830	COG1396	sequence-specific DNA binding
FH978_RS16830	COG1917	Cupin 2, conserved barrel domain protein
FH978_RS16835	COG1012	belongs to the aldehyde dehydrogenase family
FH978_RS16840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FH978_RS16845	COG0583	DNA-binding transcription factor activity
FH978_RS16850	COG0473	3-isopropylmalate dehydrogenase activity
FH978_RS16855	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FH978_RS16860	COG4638	Rieske (2fe-2S)
FH978_RS16865	COG1012	belongs to the aldehyde dehydrogenase family
FH978_RS16870	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FH978_RS16895	COG0670	Belongs to the BI1 family
FH978_RS16910	COG2207	Transcriptional regulator
FH978_RS16915	COG1881	PFAM PEBP family protein
FH978_RS16940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FH978_RS16960	COG1832	CoA-binding protein
FH978_RS16970	COG0210	DNA helicase
FH978_RS16975	COG3304	Inner membrane component domain
FH978_RS16985	COG3070	regulator of competence-specific genes
FH978_RS17010	COG1067	ATP-dependent peptidase activity
FH978_RS17020	COG3130	regulation of translation
FH978_RS17025	COG3009	Protein conserved in bacteria
FH978_RS17030	COG3008	intermembrane lipid transfer
FH978_RS17030	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FH978_RS17035	COG2995	paraquat-inducible protein a
FH978_RS17040	COG0488	(ABC) transporter
FH978_RS17050	COG0633	Ferredoxin
FH978_RS17050	COG3217	Mosc domain protein beta barrel domain protein
FH978_RS17065	COG0431	NADPH-dependent FMN reductase
FH978_RS17070	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FH978_RS17075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FH978_RS17080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FH978_RS17090	COG0308	aminopeptidase N
FH978_RS17100	COG1473	amidohydrolase
FH978_RS17110	COG0814	amino acid
FH978_RS17120	COG1522	sequence-specific DNA binding
FH978_RS17130	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FH978_RS17135	COG1448	Aminotransferase
FH978_RS17140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FH978_RS17145	COG3108	Peptidase M15
FH978_RS17150	COG2989	Protein conserved in bacteria
FH978_RS17160	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
FH978_RS17170	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FH978_RS17175	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FH978_RS17180	COG3173	Aminoglycoside phosphotransferase
FH978_RS17195	COG3214	Protein conserved in bacteria
FH978_RS17210	COG2333	competence protein COMEC
FH978_RS17210	COG0658	competence protein
FH978_RS17220	COG0539	negative regulation of cytoplasmic translation
FH978_RS17240	COG2323	membrane
FH978_RS17245	COG1944	ATP diphosphatase activity
FH978_RS17250	COG2116	formate transmembrane transporter activity
FH978_RS17255	COG1882	Formate acetyltransferase
FH978_RS17260	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FH978_RS17265	COG0477	Major facilitator Superfamily
FH978_RS17275	COG3302	dmso reductase anchor subunit
FH978_RS17280	COG0437	4 iron, 4 sulfur cluster binding
FH978_RS17285	COG0243	molybdopterin cofactor binding
FH978_RS17295	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FH978_RS17305	COG1178	ABC-type Fe3 transport system permease component
FH978_RS17305	COG1674	ftsk spoiiie
FH978_RS17315	COG0492	ferredoxin-NADP+ reductase activity
FH978_RS17320	COG4988	ABC transporter
FH978_RS17325	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FH978_RS17350	COG1278	Cold shock
FH978_RS17360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FH978_RS17365	COG3593	DNA synthesis involved in DNA repair
FH978_RS17375	COG2431	L-lysine efflux transmembrane transporter activity
FH978_RS17385	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FH978_RS17395	COG0028	Belongs to the TPP enzyme family
FH978_RS17400	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
FH978_RS17405	COG0702	epimerase
FH978_RS17410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FH978_RS17415	COG3023	N-Acetylmuramoyl-L-alanine amidase
FH978_RS17420	COG5001	Diguanylate cyclase
FH978_RS17420	COG4251	negative regulation of phosphorylation
FH978_RS17420	COG3706	GGDEF domain
FH978_RS17420	COG2203	Gaf domain
FH978_RS17430	COG1126	abc transporter atp-binding protein
FH978_RS17435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FH978_RS17440	COG4215	(ABC) transporter
FH978_RS17445	COG4160	amino acid transport
FH978_RS17450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FH978_RS17455	COG5002	protein histidine kinase activity
FH978_RS17460	COG0745	RESPONSE REGULATOR receiver
FH978_RS17475	COG1177	transmembrane transport
FH978_RS17480	COG1176	ABC-type spermidine putrescine transport system, permease component I
FH978_RS17485	COG3842	ATPase activity
FH978_RS17490	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FH978_RS17505	COG0778	Nitroreductase
FH978_RS17530	COG3226	Transcriptional regulator
FH978_RS17535	COG0738	Major facilitator superfamily
FH978_RS17540	COG0561	phosphatase activity
FH978_RS17545	COG2814	Major facilitator Superfamily
FH978_RS17555	COG0671	phosphoesterase, PA-phosphatase related
FH978_RS17560	COG1349	DNA-binding transcription factor activity
FH978_RS17565	COG1686	Belongs to the peptidase S11 family
FH978_RS17575	COG0625	glutathione transferase activity
FH978_RS17580	COG2133	pyrroloquinoline quinone binding
FH978_RS17590	COG2223	nitrite transmembrane transporter activity
FH978_RS17610	COG0747	negative chemotaxis
FH978_RS17625	COG0303	'Molybdopterin
FH978_RS17630	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FH978_RS17635	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FH978_RS17640	COG1882	Formate acetyltransferase
FH978_RS17645	COG0561	phosphatase activity
FH978_RS17655	COG1609	Transcriptional regulator
FH978_RS17660	COG2271	Major facilitator Superfamily
FH978_RS17670	COG0488	(ABC) transporter
FH978_RS17675	COG2365	Tyrosine phosphatase family
FH978_RS17680	COG1376	ErfK ybiS ycfS ynhG family protein
FH978_RS17685	COG2188	Transcriptional regulator
FH978_RS17690	COG2723	6-phospho-beta-galactosidase activity
FH978_RS17695	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FH978_RS17710	COG2194	sulfuric ester hydrolase activity
FH978_RS17715	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FH978_RS17730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FH978_RS17735	COG0765	amino acid transport
FH978_RS17740	COG1126	abc transporter atp-binding protein
FH978_RS17745	COG0668	transmembrane transport
FH978_RS17755	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FH978_RS17765	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FH978_RS17780	COG1199	ATP-dependent helicase activity
FH978_RS17785	COG0513	Belongs to the DEAD box helicase family
FH978_RS17790	COG3958	Transketolase
FH978_RS17795	COG3959	Transketolase, thiamine diphosphate binding domain
FH978_RS17800	COG1028	Short-chain dehydrogenase reductase Sdr
FH978_RS17805	COG2271	Major facilitator Superfamily
FH978_RS17810	COG0583	DNA-binding transcription factor activity
FH978_RS17815	COG1309	transcriptional regulator
FH978_RS17820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FH978_RS17825	COG1131	(ABC) transporter
FH978_RS17830	COG0842	Transport permease protein
FH978_RS17835	COG0842	Transport permease protein
FH978_RS17845	COG3568	Endonuclease Exonuclease Phosphatase
FH978_RS17850	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FH978_RS17855	COG0392	lysyltransferase activity
FH978_RS17870	COG0670	Belongs to the BI1 family
FH978_RS17875	COG0314	molybdopterin synthase activity
FH978_RS17880	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FH978_RS17890	COG0521	Mo-molybdopterin cofactor biosynthetic process
FH978_RS17920	COG0642	Histidine kinase
FH978_RS17950	COG2226	methyltransferase
FH978_RS17965	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FH978_RS17970	COG1881	PFAM PEBP family protein
FH978_RS18005	COG4677	pectinesterase activity
FH978_RS18015	COG0589	response to stress
FH978_RS18020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FH978_RS18050	COG0789	Transcriptional regulator
FH978_RS18055	COG2200	EAL domain
FH978_RS18080	COG0561	phosphatase activity
FH978_RS18090	COG4149	molybdate abc transporter
FH978_RS18095	COG0725	ABC transporter, periplasmic molybdate-binding protein
FH978_RS18105	COG3585	molybdate ion transport
FH978_RS18105	COG2005	Transcriptional regulator
FH978_RS18110	COG1119	ATPase activity
FH978_RS18120	COG1085	galactose-1-phosphate uridylyltransferase
FH978_RS18130	COG2017	converts alpha-aldose to the beta-anomer
FH978_RS18140	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FH978_RS18155	COG3201	nicotinamide mononucleotide transporter
FH978_RS18160	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FH978_RS18205	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
FH978_RS18210	COG2885	chlorophyll binding
FH978_RS18220	COG3064	Membrane
FH978_RS18220	COG3064	Membrane
FH978_RS18225	COG0848	biopolymer transport protein
FH978_RS18230	COG0811	peptide transport
FH978_RS18235	COG0824	Thioesterase
FH978_RS18240	COG3790	cyd operon protein YbgE
FH978_RS18245	COG4890	Cyd operon protein YbgT
FH978_RS18250	COG1294	oxidase, subunit
FH978_RS18255	COG1271	oxidase subunit
FH978_RS18265	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FH978_RS18275	COG0508	dehydrogenase complex catalyzes the overall conversion of
FH978_RS18280	COG0567	Dehydrogenase, E1 component
FH978_RS18285	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FH978_RS18290	COG1053	succinate dehydrogenase
FH978_RS18295	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FH978_RS18300	COG2009	succinate dehydrogenase
FH978_RS18335	COG1984	allophanate hydrolase subunit 2
FH978_RS18340	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FH978_RS18355	COG0415	Belongs to the DNA photolyase family
FH978_RS18390	COG0745	RESPONSE REGULATOR receiver
FH978_RS18400	COG0033	Phosphoglucomutase
FH978_RS18410	COG0596	Alpha beta hydrolase
FH978_RS18425	COG0735	belongs to the Fur family
FH978_RS18465	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FH978_RS18470	COG1846	Transcriptional regulator
FH978_RS18470	COG1940	carbohydrate kinase activity
FH978_RS18475	COG0647	UMP catabolic process
FH978_RS18480	COG0367	asparagine synthase
FH978_RS18525	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FH978_RS18535	COG1702	phosphate starvation-inducible protein PhoH
FH978_RS18560	COG0765	amino acid transport
FH978_RS18565	COG0765	amino acid transport
FH978_RS18570	COG1126	abc transporter atp-binding protein
FH978_RS18585	COG2888	peptidyl-tyrosine sulfation
FH978_RS18600	COG1466	dna polymerase III delta subunit
FH978_RS18615	COG0799	negative regulation of ribosome biogenesis
FH978_RS18625	COG0768	penicillin binding
FH978_RS18630	COG0772	Belongs to the SEDS family
FH978_RS18635	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FH978_RS18640	COG1686	Belongs to the peptidase S11 family
FH978_RS18655	COG0583	DNA-binding transcription factor activity
FH978_RS18670	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FH978_RS18690	COG3069	C4-dicarboxylate transmembrane transporter activity
FH978_RS18695	COG3719	Belongs to the RNase T2 family
FH978_RS18700	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FH978_RS18720	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FH978_RS18730	COG3969	phosphoadenosine phosphosulfate
FH978_RS18740	COG0436	Aminotransferase
FH978_RS18765	COG1129	ABC transporter
FH978_RS18770	COG1172	Belongs to the binding-protein-dependent transport system permease family
FH978_RS18775	COG1172	Belongs to the binding-protein-dependent transport system permease family
FH978_RS18785	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FH978_RS18800	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FH978_RS18810	COG0402	S-adenosylhomocysteine deaminase activity
FH978_RS18820	COG0483	inositol monophosphate 1-phosphatase activity
FH978_RS18825	COG2271	Major facilitator Superfamily
FH978_RS18855	COG1172	Belongs to the binding-protein-dependent transport system permease family
FH978_RS18860	COG1129	ABC transporter
FH978_RS18865	COG0371	Dehydrogenase
FH978_RS18870	COG1028	Short-chain dehydrogenase reductase Sdr
FH978_RS18885	COG2879	small protein
FH978_RS18900	COG1028	Short-chain dehydrogenase reductase Sdr
FH978_RS18905	COG1535	isochorismatase
FH978_RS18905	COG3433	isochorismatase activity
FH978_RS18910	COG1021	2,3-dihydroxybenzoate-AMP ligase
FH978_RS18915	COG1169	isochorismate synthase
FH978_RS18920	COG4592	Periplasmic binding protein
FH978_RS18930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FH978_RS18935	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FH978_RS18940	COG1120	ATPase activity
FH978_RS18950	COG3251	PFAM MbtH domain protein
FH978_RS18955	COG2382	esterase
FH978_RS18960	COG4771	TonB-dependent receptor
FH978_RS18970	COG1879	ABC-type sugar transport system periplasmic component
FH978_RS18980	COG1129	ABC transporter
FH978_RS18985	COG1172	Belongs to the binding-protein-dependent transport system permease family
FH978_RS18990	COG5464	transposase or invertase
FH978_RS18995	COG2390	Transcriptional regulator
FH978_RS19000	COG3959	Transketolase, thiamine diphosphate binding domain
FH978_RS19005	COG3958	Transketolase
FH978_RS19015	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FH978_RS19025	COG0583	DNA-binding transcription factor activity
FH978_RS19030	COG0668	transmembrane transport
FH978_RS19040	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FH978_RS19065	COG0747	negative chemotaxis
FH978_RS19070	COG0601	transmembrane transport
FH978_RS19075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FH978_RS19080	COG0444	Belongs to the ABC transporter superfamily
FH978_RS19085	COG4608	Belongs to the ABC transporter superfamily
FH978_RS19095	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FH978_RS19100	COG4221	oxidoreductase activity
FH978_RS19110	COG4215	(ABC) transporter
FH978_RS19115	COG0765	amino acid transport
FH978_RS19120	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FH978_RS19135	COG0697	spore germination
FH978_RS19145	COG3698	Phosphodiester glycosidase
FH978_RS19195	COG2315	Protein conserved in bacteria
FH978_RS19200	COG0778	Nitroreductase
FH978_RS19210	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FH978_RS19220	COG3716	PTS system mannose fructose sorbose family IID component
FH978_RS19225	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FH978_RS19230	COG2222	sugar isomerase
FH978_RS19235	COG3933	PFAM sigma-54 factor interaction domain-containing protein
FH978_RS19235	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
FH978_RS19250	COG0477	Major facilitator Superfamily
FH978_RS19255	COG0668	transmembrane transport
FH978_RS19270	COG0673	inositol 2-dehydrogenase activity
FH978_RS19280	COG2211	Major facilitator Superfamily
FH978_RS19285	COG1113	amino acid transport
FH978_RS19300	COG1012	belongs to the aldehyde dehydrogenase family
FH978_RS19305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FH978_RS19315	COG0531	amino acid
FH978_RS19360	COG0667	Aldo Keto reductase
FH978_RS19365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FH978_RS19370	COG1473	amidohydrolase
FH978_RS19390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FH978_RS19395	COG1120	ATPase activity
FH978_RS19400	COG1566	PFAM secretion protein HlyD family protein
FH978_RS19445	COG4211	Belongs to the binding-protein-dependent transport system permease family
FH978_RS19450	COG1129	ABC transporter
FH978_RS19465	COG0673	inositol 2-dehydrogenase activity
FH978_RS19495	COG3104	oligopeptide transport
FH978_RS19500	COG1982	Orn Lys Arg decarboxylase major
FH978_RS19505	COG0531	amino acid
FH978_RS19525	COG1560	Kdo2-lipid A biosynthetic process
FH978_RS19545	COG3121	Chaperone
FH978_RS19550	COG3539	Fimbrial protein
FH978_RS19745	COG3772	lysozyme
FH978_RS19925	COG0582	viral genome integration into host DNA
FH978_RS19945	COG2501	S4 domain
FH978_RS19955	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FH978_RS19970	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FH978_RS19975	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FH978_RS19995	COG4181	ATPase activity
FH978_RS20000	COG2755	lipolytic protein G-D-S-L family
FH978_RS20005	COG0300	oxidoreductase activity
FH978_RS20010	COG3118	belongs to the thioredoxin family
FH978_RS20020	COG0390	transport system, permease component
FH978_RS20025	COG4619	ABC transporter
FH978_RS20030	COG0330	HflC and HflK could
FH978_RS20035	COG1585	Membrane protein implicated in regulation of membrane protease activity
FH978_RS20050	COG3735	TraB family
FH978_RS20055	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FH978_RS20065	COG2223	nitrite transmembrane transporter activity
FH978_RS20070	COG4651	solute:proton antiporter activity
FH978_RS20070	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FH978_RS20075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FH978_RS20115	COG2832	Protein of unknown function (DUF454)
FH978_RS20120	COG3923	Primosomal replication protein n
FH978_RS20135	COG3264	Mechanosensitive ion channel
FH978_RS20135	COG1196	nuclear chromosome segregation
FH978_RS20140	COG1309	transcriptional regulator
FH978_RS20145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FH978_RS20150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FH978_RS20165	COG0110	maltose O-acetyltransferase activity
FH978_RS20210	COG1874	Beta-galactosidase
FH978_RS20215	COG3867	Arabinogalactan endo-beta-1,4-galactanase
FH978_RS20225	COG1175	transmembrane transport
FH978_RS20230	COG2182	Extracellular solute-binding protein
FH978_RS20240	COG4943	cyclic-guanylate-specific phosphodiesterase activity
FH978_RS20255	COG2364	Membrane
FH978_RS20285	COG3695	enzyme binding
FH978_RS20290	COG3126	Type III secretion system lipoprotein chaperone (YscW)
FH978_RS20295	COG1946	Acyl-CoA thioesterase
FH978_RS20300	COG0004	ammonium transporteR
FH978_RS20305	COG0347	Belongs to the P(II) protein family
FH978_RS20320	COG1522	sequence-specific DNA binding
FH978_RS20335	COG4533	DNA binding
FH978_RS20345	COG0824	Thioesterase
FH978_RS20350	COG1555	photosystem II stabilization
FH978_RS20355	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FH978_RS20360	COG0776	regulation of translation
FH978_RS20365	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FH978_RS20395	COG0271	Belongs to the BolA IbaG family
FH978_RS20400	COG3056	Lipoprotein
FH978_RS20405	COG2223	nitrite transmembrane transporter activity
FH978_RS20410	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FH978_RS20415	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FH978_RS20420	COG1845	cytochrome c oxidase, subunit III
FH978_RS20425	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FH978_RS20440	COG1414	Transcriptional regulator
FH978_RS20445	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FH978_RS20450	COG1053	succinate dehydrogenase
FH978_RS20460	COG1053	succinate dehydrogenase
FH978_RS20475	COG0673	inositol 2-dehydrogenase activity
FH978_RS20480	COG2814	Major facilitator Superfamily
FH978_RS20490	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FH978_RS20495	COG0693	protein deglycase activity
FH978_RS20515	COG0142	geranyltranstransferase activity
FH978_RS20525	COG0667	Aldo Keto reductase
FH978_RS20530	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FH978_RS20550	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FH978_RS20550	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FH978_RS20560	COG4238	major outer membrane lipoprotein
FH978_RS20580	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FH978_RS20585	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FH978_RS20590	COG1862	Preprotein translocase
FH978_RS20610	COG0450	alkyl hydroperoxide reductase
FH978_RS20615	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FH978_RS20630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FH978_RS20640	COG1228	amidohydrolase
FH978_RS20650	COG1335	isochorismatase
FH978_RS20655	COG0583	DNA-binding transcription factor activity
FH978_RS20660	COG0366	Alpha amylase catalytic
FH978_RS20685	COG0420	3'-5' exonuclease activity
FH978_RS20690	COG0419	ATPase involved in DNA repair
FH978_RS20695	COG1940	carbohydrate kinase activity
FH978_RS20710	COG4126	flavin adenine dinucleotide binding
FH978_RS20720	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FH978_RS20735	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FH978_RS20745	COG1785	Belongs to the alkaline phosphatase family
FH978_RS20785	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
FH978_RS20790	COG1335	isochorismatase
FH978_RS20795	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FH978_RS20800	COG0113	porphobilinogen synthase activity
FH978_RS20815	COG2175	clavaminate synthase activity
FH978_RS20820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FH978_RS20825	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FH978_RS20830	COG4521	taurine ABC transporter
FH978_RS20835	COG2040	homocysteine
FH978_RS20840	COG0833	amino acid
FH978_RS20850	COG4303	Ethanolamine ammonia lyase large subunit
FH978_RS20855	COG4302	ethanolamine ammonia-lyase activity
FH978_RS20895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FH978_RS20900	COG1126	abc transporter atp-binding protein
FH978_RS20905	COG4597	amino acid ABC transporter
FH978_RS20910	COG0765	amino acid transport
FH978_RS20925	COG3188	usher protein
FH978_RS20950	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
FH978_RS20960	COG3639	organic phosphonate transmembrane transporter activity
FH978_RS20980	COG0791	NLP P60 protein
FH978_RS21030	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FH978_RS21035	COG0022	dehydrogenase e1 component
FH978_RS21040	COG0508	dehydrogenase complex catalyzes the overall conversion of
FH978_RS21080	COG1070	Carbohydrate kinase
FH978_RS21085	COG1028	Short-chain dehydrogenase reductase Sdr
FH978_RS21090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FH978_RS21095	COG3775	system Galactitol-specific IIC component
FH978_RS21100	COG0625	glutathione transferase activity
FH978_RS21105	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
FH978_RS21120	COG0579	oxidoreductase
FH978_RS21125	COG1012	belongs to the aldehyde dehydrogenase family
FH978_RS21130	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FH978_RS21135	COG1113	amino acid transport
FH978_RS21140	COG1802	Transcriptional regulator
FH978_RS21160	COG2195	Cleaves the N-terminal amino acid of tripeptides
FH978_RS21165	COG0454	-acetyltransferase
FH978_RS21180	COG2991	Protein conserved in bacteria
FH978_RS21195	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FH978_RS21200	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FH978_RS21215	COG3034	peptidoglycan biosynthetic process
FH978_RS21220	COG0121	glutamine amidotransferase
FH978_RS21230	COG1960	acyl-CoA dehydrogenase activity
FH978_RS21235	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FH978_RS21245	COG0583	DNA-binding transcription factor activity
FH978_RS21255	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FH978_RS21265	COG2226	methyltransferase
FH978_RS21275	COG0741	lytic transglycosylase activity
FH978_RS21275	COG1388	LysM domain
FH978_RS21280	COG2226	methyltransferase
FH978_RS21290	COG2814	Major facilitator Superfamily
FH978_RS21295	COG0583	DNA-binding transcription factor activity
FH978_RS21300	COG0656	L-ascorbic acid biosynthetic process
FH978_RS21335	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FH978_RS21345	COG2011	ABC-type metal ion transport system permease component
FH978_RS21350	COG1464	Belongs to the NlpA lipoprotein family
FH978_RS21360	COG1720	tRNA m6t6A37 methyltransferase activity
FH978_RS21370	COG0791	NLP P60 protein
FH978_RS21375	COG3015	lipoprotein NlpE involved in copper resistance
FH978_RS21380	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FH978_RS21395	COG4568	rho-dependent transcription termination
FH978_RS21405	COG0346	lactoylglutathione lyase activity
FH978_RS21410	COG1982	Orn Lys Arg decarboxylase major
FH978_RS21420	COG0587	DNA-directed DNA polymerase activity
FH978_RS21450	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
FH978_RS21460	COG0750	zinc metalloprotease
FH978_RS21465	COG0575	Belongs to the CDS family
FH978_RS21480	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FH978_RS21505	COG0024	Methionine aminopeptidase
FH978_RS21510	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FH978_RS21525	COG3835	regulator
FH978_RS21530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FH978_RS21550	COG2860	membrane
FH978_RS21570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FH978_RS21575	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FH978_RS21580	COG1120	ATPase activity
FH978_RS21585	COG4774	siderophore transport
FH978_RS21590	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FH978_RS21675	COG1643	Atp-dependent helicase
FH978_RS21680	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
FH978_RS21700	COG0617	tRNA 3'-terminal CCA addition
FH978_RS21725	COG0726	polysaccharide deacetylase
FH978_RS21730	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FH978_RS21735	COG0842	Transport permease protein
FH978_RS21740	COG1131	(ABC) transporter
FH978_RS21745	COG0288	reversible hydration of carbon dioxide
FH978_RS21755	COG4993	Dehydrogenase
FH978_RS21805	COG3064	Membrane
FH978_RS21820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FH978_RS21825	COG0508	dehydrogenase complex catalyzes the overall conversion of
FH978_RS21830	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FH978_RS21835	COG2186	Transcriptional regulator
FH978_RS21840	COG1113	amino acid transport
FH978_RS21845	COG2211	Major facilitator Superfamily
FH978_RS21850	COG3940	Belongs to the glycosyl hydrolase 43 family
FH978_RS21855	COG3725	Membrane protein required for beta-lactamase induction
FH978_RS21860	COG3023	N-Acetylmuramoyl-L-alanine amidase
FH978_RS21870	COG4969	Belongs to the N-Me-Phe pilin family
FH978_RS21875	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FH978_RS21880	COG1459	type II secretion system
FH978_RS21905	COG0494	nUDIX hydrolase
FH978_RS21925	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FH978_RS21930	COG0849	cell division
FH978_RS21955	COG0772	Belongs to the SEDS family
FH978_RS21970	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FH978_RS21975	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FH978_RS21980	COG0768	penicillin binding
FH978_RS22000	COG1609	Transcriptional regulator
FH978_RS22010	COG0028	Belongs to the TPP enzyme family
FH978_RS22060	COG0738	Major facilitator superfamily
FH978_RS22075	COG2271	Major facilitator Superfamily
FH978_RS22100	COG1178	ABC-type Fe3 transport system permease component
FH978_RS22110	COG0586	Pfam SNARE associated Golgi protein
FH978_RS22130	COG0235	Class ii aldolase
FH978_RS22135	COG0417	DNA replication proofreading
FH978_RS22145	COG0564	pseudouridine synthase activity
FH978_RS22155	COG3493	citrate carrier protein
FH978_RS22170	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FH978_RS22185	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FH978_RS22230	COG0505	Belongs to the CarA family
FH978_RS22295	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FH978_RS22320	COG1047	Peptidyl-prolyl cis-trans
FH978_RS22335	COG0196	riboflavin kinase activity
FH978_RS22350	COG0583	DNA-binding transcription factor activity
FH978_RS22375	COG4735	regulation of single-species biofilm formation
FH978_RS22380	COG1584	GPR1 FUN34 yaaH family protein
FH978_RS22385	COG0477	Major facilitator Superfamily
FH978_RS22390	COG0521	Mo-molybdopterin cofactor biosynthetic process
FH978_RS22395	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FH978_RS22400	COG1115	amino acid carrier protein
FH978_RS22415	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FH978_RS22425	COG0460	homoserine dehydrogenase
FH978_RS22425	COG0527	aspartate kinase activity
FH978_RS22435	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
FH978_RS22445	COG0745	RESPONSE REGULATOR receiver
FH978_RS22450	COG4452	Inner membrane protein CreD
FH978_RS22455	COG2205	protein histidine kinase activity
FH978_RS22460	COG0745	RESPONSE REGULATOR receiver
FH978_RS22465	COG3045	CreA protein
FH978_RS22490	COG0741	lytic transglycosylase activity
FH978_RS22495	COG0488	(ABC) transporter
FH978_RS22505	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FH978_RS22510	COG0560	Phosphoserine phosphatase
FH978_RS22515	COG3726	membrane protein affecting hemolysin expression
FH978_RS22545	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FH978_RS22550	COG0084	hydrolase, TatD family'
FH978_RS22555	COG4667	esterase of the alpha-beta hydrolase superfamily
FH978_RS22565	COG2823	Periplasmic or secreted lipoprotein
FH978_RS22575	COG1011	Hydrolase
FH978_RS22580	COG0456	acetyltransferase
FH978_RS22585	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
FH978_RS22615	COG3706	GGDEF domain
FH978_RS22620	COG4114	ferric iron reductase
FH978_RS22630	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FH978_RS22635	COG2197	response regulator
FH978_RS22640	COG2197	response regulator
FH978_RS22655	COG2966	Psort location CytoplasmicMembrane, score
FH978_RS22670	COG1484	DNA-dependent DNA replication
FH978_RS22685	COG5464	transposase or invertase
FH978_RS22695	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FH978_RS22700	COG3716	PTS system mannose fructose sorbose family IID component
FH978_RS22705	COG3715	PTS system
FH978_RS22720	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
FH978_RS22720	COG3933	PFAM sigma-54 factor interaction domain-containing protein
FH978_RS22725	COG1214	PFAM Peptidase M22, glycoprotease
FH978_RS22725	COG0456	acetyltransferase
FH978_RS22735	COG1737	Transcriptional regulator
FH978_RS22740	COG0800	Aldolase
FH978_RS22745	COG3734	2-keto-3-deoxy-galactonokinase
FH978_RS22760	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
FH978_RS22790	COG1846	Transcriptional regulator
FH978_RS22800	COG0179	Fumarylacetoacetate (FAA) hydrolase
FH978_RS22810	COG1012	belongs to the aldehyde dehydrogenase family
FH978_RS22815	COG3384	dioxygenase
FH978_RS22825	COG3971	2-oxopent-4-enoate hydratase activity
FH978_RS22845	COG2368	4-hydroxyphenylacetate
FH978_RS22850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FH978_RS22865	COG1966	Carbon starvation protein
FH978_RS22870	COG2879	small protein
FH978_RS22875	COG0523	cobalamin synthesis protein
FH978_RS22885	COG1012	belongs to the aldehyde dehydrogenase family
FH978_RS22890	COG5464	transposase or invertase
FH978_RS22895	COG1917	Cupin 2, conserved barrel domain protein
FH978_RS22895	COG2207	Transcriptional regulator
FH978_RS22905	COG2733	membrane
FH978_RS22920	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
FH978_RS22925	COG1924	4 iron, 4 sulfur cluster binding
FH978_RS22940	COG1566	PFAM secretion protein HlyD family protein
FH978_RS22950	COG5457	Domain of unknown function (DUF1127)
FH978_RS22955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FH978_RS22970	COG0583	DNA-binding transcription factor activity
FH978_RS22975	COG2249	NAD(P)H dehydrogenase (quinone) activity
FH978_RS22985	COG1172	Belongs to the binding-protein-dependent transport system permease family
FH978_RS22990	COG1129	ABC transporter
FH978_RS22995	COG1879	ABC-type sugar transport system periplasmic component
FH978_RS23005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FH978_RS23010	COG1129	ABC transporter
FH978_RS23010	COG0842	Transport permease protein
FH978_RS23015	COG0842	Transport permease protein
FH978_RS23045	COG2850	peptidyl-arginine hydroxylation
FH978_RS23060	COG5002	protein histidine kinase activity
FH978_RS23065	COG0745	RESPONSE REGULATOR receiver
FH978_RS23070	COG1538	Outer membrane efflux protein
FH978_RS23075	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FH978_RS23080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FH978_RS23085	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FH978_RS23095	COG3040	lipid binding
FH978_RS23100	COG0789	Transcriptional regulator
FH978_RS23110	COG0300	oxidoreductase activity
FH978_RS23125	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FH978_RS23145	COG3272	Protein of unknown function (DUF1722)
FH978_RS23150	COG4580	involved in the transport of maltose and maltodextrins
FH978_RS23155	COG2115	Belongs to the xylose isomerase family
FH978_RS23160	COG2211	Major facilitator Superfamily
FH978_RS23165	COG3507	Belongs to the glycosyl hydrolase 43 family
FH978_RS23220	COG0210	DNA helicase
FH978_RS23240	COG3429	Glucose-6-phosphate dehydrogenase subunit
FH978_RS23240	COG3409	Peptidoglycan-binding domain 1 protein
FH978_RS23315	COG0582	viral genome integration into host DNA
FH978_RS23325	COG0288	reversible hydration of carbon dioxide
FH978_RS23330	COG0659	secondary active sulfate transmembrane transporter activity
FH978_RS23335	COG1064	alcohol dehydrogenase
FH978_RS23340	COG1175	transmembrane transport
FH978_RS23345	COG0395	ABC-type sugar transport system, permease component
FH978_RS23350	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FH978_RS23355	COG3842	ATPase activity
FH978_RS23360	COG1653	transport
FH978_RS23370	COG1082	Xylose isomerase domain protein TIM barrel
FH978_RS23380	COG3962	Belongs to the TPP enzyme family
FH978_RS23385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FH978_RS23390	COG0837	glucose binding
FH978_RS23390	COG1737	Transcriptional regulator
FH978_RS23400	COG3718	enzyme involved in inositol metabolism
FH978_RS23415	COG0433	COG0433 Predicted ATPase
FH978_RS23420	COG0795	lipopolysaccharide-transporting ATPase activity
FH978_RS23425	COG0795	lipopolysaccharide-transporting ATPase activity
FH978_RS23435	COG2927	DNA polymerase III (CHI subunit)
FH978_RS23440	COG0525	valine-tRNA ligase activity
FH978_RS23465	COG2731	YhcH YjgK YiaL family protein
FH978_RS23505	COG1263	PTS System
FH978_RS23505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FH978_RS23510	COG0366	Alpha amylase catalytic
FH978_RS23515	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FH978_RS23520	COG1486	melibiose metabolic process
FH978_RS23540	COG0602	queuosine metabolic process
FH978_RS23545	COG2026	Addiction module toxin, RelE StbE family
FH978_RS23550	COG3077	Addiction module antitoxin, RelB DinJ family
FH978_RS23555	COG3711	transcriptional antiterminator
FH978_RS23555	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FH978_RS23560	COG2706	6-phosphogluconolactonase activity
FH978_RS23575	COG3964	amidohydrolase
FH978_RS23610	COG0312	modulator of DNA gyrase
FH978_RS23630	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FH978_RS23640	COG1172	Belongs to the binding-protein-dependent transport system permease family
FH978_RS23645	COG1172	Belongs to the binding-protein-dependent transport system permease family
FH978_RS23650	COG1129	ABC transporter
FH978_RS23655	COG1879	ABC-type sugar transport system periplasmic component
FH978_RS23675	COG2105	PFAM AIG2 family protein
FH978_RS23680	COG2911	Protein conserved in bacteria
FH978_RS23685	COG0729	surface antigen
FH978_RS23695	COG1253	flavin adenine dinucleotide binding
FH978_RS23710	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
FH978_RS23725	COG1733	regulation of RNA biosynthetic process
FH978_RS23730	COG0702	epimerase
FH978_RS23740	COG0697	spore germination
FH978_RS23750	COG1113	amino acid transport
FH978_RS23755	COG0545	Peptidyl-prolyl cis-trans isomerase
FH978_RS23760	COG3061	Opacity-associated protein A
FH978_RS23770	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FH978_RS23775	COG2965	DNA replication, synthesis of RNA primer
FH978_RS23835	COG1073	alpha beta
FH978_RS23840	COG3650	response to hydrogen peroxide
FH978_RS23850	COG1960	acyl-CoA dehydrogenase activity
FH978_RS23855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FH978_RS23860	COG0557	exoribonuclease II activity
FH978_RS23875	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
FH978_RS23885	COG0330	HflC and HflK could
FH978_RS23890	COG0330	HflC and HflK could
FH978_RS23895	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FH978_RS23915	COG0860	N-Acetylmuramoyl-L-alanine amidase
FH978_RS23920	COG0802	atpase or kinase
FH978_RS23925	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FH978_RS23925	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FH978_RS23930	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FH978_RS23945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FH978_RS23965	COG1511	domain protein
FH978_RS23965	COG3264	Mechanosensitive ion channel
FH978_RS23980	COG1053	succinate dehydrogenase
FH978_RS23985	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FH978_RS24005	COG2076	Multidrug Resistance protein
FH978_RS24010	COG5510	response to toxic substance
FH978_RS24025	COG1509	lysine 2,3-aminomutase activity
FH978_RS24090	COG0531	amino acid
FH978_RS24100	COG1027	Aspartate ammonia-lyase
FH978_RS24105	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FH978_RS24120	COG1309	transcriptional regulator
FH978_RS24150	COG0457	Tetratricopeptide repeat
FH978_RS24155	COG1649	PFAM Uncharacterised BCR, COG1649
FH978_RS24155	COG0726	polysaccharide deacetylase
FH978_RS24160	COG1215	transferase activity, transferring glycosyl groups
FH978_RS24180	COG0861	Integral membrane protein TerC family
FH978_RS24210	COG1486	melibiose metabolic process
FH978_RS24215	COG2169	Transcriptional regulator
FH978_RS24230	COG2824	Alkylphosphonate utilization operon protein PhnA
FH978_RS24235	COG2764	glyoxalase bleomycin resistance protein dioxygenase
FH978_RS24240	COG2188	Transcriptional regulator
FH978_RS24245	COG3624	Phosphonate C-P lyase system protein PhnG
FH978_RS24250	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
FH978_RS24255	COG3626	phosphonate metabolism
FH978_RS24260	COG3627	carbon phosphorus lyase activity
FH978_RS24265	COG4107	phosphonate C-P lyase system protein PhnK
FH978_RS24270	COG4778	phosphonate C-P lyase system protein PhnL
FH978_RS24275	COG3454	Phosphonate metabolism
FH978_RS24285	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FH978_RS24295	COG4191	Histidine kinase
FH978_RS24295	COG0784	Response regulator, receiver
FH978_RS24300	COG1129	ABC transporter
FH978_RS24305	COG1172	Belongs to the binding-protein-dependent transport system permease family
FH978_RS24345	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
FH978_RS24350	COG1301	dicarboxylic acid transport
FH978_RS24360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FH978_RS24365	COG3162	membrane
FH978_RS24395	COG3539	Fimbrial protein
FH978_RS24400	COG1346	cytolysis
FH978_RS24405	COG1380	Effector of murein hydrolase LrgA
FH978_RS24410	COG0583	DNA-binding transcription factor activity
FH978_RS24420	COG2252	PERMEase
FH978_RS24425	COG0625	glutathione transferase activity
FH978_RS24430	COG0789	Transcriptional regulator
FH978_RS24440	COG4943	cyclic-guanylate-specific phosphodiesterase activity
FH978_RS24475	COG1234	tRNA 3'-trailer cleavage
FH978_RS24480	COG1609	Transcriptional regulator
FH978_RS24485	COG0483	inositol monophosphate 1-phosphatase activity
FH978_RS24500	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FH978_RS24525	COG0741	lytic transglycosylase activity
FH978_RS24540	COG2315	Protein conserved in bacteria
FH978_RS24545	COG0432	Pfam Uncharacterised protein family UPF0047
FH978_RS24560	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FH978_RS24565	COG0305	Participates in initiation and elongation during chromosome replication
FH978_RS24580	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FH978_RS24590	COG0735	belongs to the Fur family
FH978_RS24595	COG3237	CsbD-like
FH978_RS24600	COG0534	Mate efflux family protein
FH978_RS24610	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FH978_RS24680	COG0251	oxidation-reduction process
FH978_RS24690	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FH978_RS24700	COG0527	aspartate kinase activity
FH978_RS24755	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FH978_RS24785	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FH978_RS24795	COG0456	acetyltransferase
FH978_RS24825	COG0151	Belongs to the GarS family
FH978_RS24835	COG4191	Histidine kinase
FH978_RS24840	COG3678	ATP-independent chaperone mediated protein folding
FH978_RS24875	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
FH978_RS24890	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FH978_RS24895	COG2104	thiamine diphosphate biosynthetic process
FH978_RS24910	COG3706	GGDEF domain
FH978_RS24920	COG1447	Phosphotransferase system cellobiose-specific component IIA
FH978_RS24925	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FH978_RS24960	COG0250	Participates in transcription elongation, termination and antitermination
FH978_RS25035	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
FH978_RS25045	COG1739	Uncharacterized protein family UPF0029
FH978_RS25085	COG0805	protein transport
FH978_RS25105	COG3165	ubiquinone biosynthetic process from chorismate
FH978_RS25135	COG0583	DNA-binding transcription factor activity
FH978_RS25140	COG0697	spore germination
FH978_RS25145	COG0561	phosphatase activity
FH978_RS25150	COG2267	carboxylic ester hydrolase activity
FH978_RS25155	COG1280	lysine exporter protein (LysE YggA)
FH978_RS25165	COG1280	lysine exporter protein (LysE YggA)
FH978_RS25195	COG0210	DNA helicase
FH978_RS25200	COG1011	Hydrolase
FH978_RS25230	COG3072	Adenylate cyclase
FH978_RS25245	COG2959	enzyme of heme biosynthesis
FH978_RS25250	COG3071	HemY protein
FH978_RS25295	COG2244	polysaccharide biosynthetic process
FH978_RS25300	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FH978_RS25305	COG0456	acetyltransferase
FH978_RS25310	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FH978_RS25315	COG1088	dTDP-glucose 4,6-dehydratase activity
FH978_RS25320	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FH978_RS25325	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FH978_RS25340	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FH978_RS25350	COG3118	belongs to the thioredoxin family
FH978_RS25375	COG1811	Na channel or pump
FH978_RS25385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FH978_RS25390	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FH978_RS25400	COG0583	DNA-binding transcription factor activity
FH978_RS25405	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FH978_RS25420	COG3978	acetolactate synthase activity
FH978_RS25515	COG0583	DNA-binding transcription factor activity
FH978_RS25530	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FH978_RS25545	COG3443	Belongs to the bacterial solute-binding protein 9 family
FH978_RS25550	COG2207	Transcriptional regulator
FH978_RS25560	COG0371	Dehydrogenase
FH978_RS25565	COG0697	spore germination
FH978_RS25575	COG0583	DNA-binding transcription factor activity
FH978_RS25585	COG0737	Belongs to the 5'-nucleotidase family
FH978_RS25595	COG0460	homoserine dehydrogenase
FH978_RS25595	COG0527	aspartate kinase activity
FH978_RS25600	COG0626	cystathionine gamma-synthase activity
FH978_RS25615	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FH978_RS25620	COG1609	Transcriptional regulator
FH978_RS25625	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FH978_RS25640	COG1575	Belongs to the MenA family. Type 1 subfamily
FH978_RS25665	COG0745	RESPONSE REGULATOR receiver
FH978_RS25670	COG2205	protein histidine kinase activity
FH978_RS25675	COG2258	MOSC domain
FH978_RS25680	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FH978_RS25725	COG1129	ABC transporter
FH978_RS25730	COG1172	Belongs to the binding-protein-dependent transport system permease family
FH978_RS25735	COG1172	Belongs to the binding-protein-dependent transport system permease family
FH978_RS25740	COG1454	alcohol dehydrogenase
FH978_RS25750	COG2211	Major facilitator Superfamily
FH978_RS25810	COG0205	6-phosphofructokinase activity
FH978_RS25830	COG0437	4 iron, 4 sulfur cluster binding
FH978_RS25835	COG2864	formate dehydrogenase
FH978_RS25850	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FH978_RS25860	COG0456	acetyltransferase
FH978_RS25875	COG1011	Hydrolase
FH978_RS25890	COG3852	Histidine kinase
FH978_RS25930	COG0204	Acyl-transferase
FH978_RS25940	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FH978_RS25945	COG3084	Protein conserved in bacteria
FH978_RS25955	COG1763	Mo-molybdopterin cofactor biosynthetic process
FH978_RS25985	COG2186	Transcriptional regulator
FH978_RS25990	COG0477	Major facilitator Superfamily
FH978_RS25995	COG1609	Transcriptional regulator
FH978_RS26000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FH978_RS26010	COG1172	Belongs to the binding-protein-dependent transport system permease family
FH978_RS26015	COG1129	ABC transporter
FH978_RS26045	COG1522	sequence-specific DNA binding
FH978_RS26050	COG0716	FMN binding
FH978_RS26065	COG3312	ion transport
FH978_RS26120	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FH978_RS26125	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FH978_RS26130	COG0573	inorganic phosphate transmembrane transporter activity
FH978_RS26135	COG0581	inorganic phosphate transmembrane transporter activity
FH978_RS26140	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FH978_RS26145	COG0704	Plays a role in the regulation of phosphate uptake
FH978_RS26155	COG2382	esterase
FH978_RS26160	COG0363	glucosamine-6-phosphate deaminase activity
FH978_RS26165	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FH978_RS26175	COG2252	PERMEase
FH978_RS26180	COG0431	NADPH-dependent FMN reductase
FH978_RS26185	COG2091	lysine biosynthetic process via aminoadipic acid
FH978_RS26215	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FH978_RS26260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FH978_RS26285	COG0656	L-ascorbic acid biosynthetic process
FH978_RS26290	COG2916	Histone family protein nucleoid-structuring protein H-NS
FH978_RS26310	COG5654	RES domain protein
FH978_RS26315	COG5642	Protein of unknown function (DUF2384)
FH978_RS26330	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FH978_RS26335	COG4772	TonB-dependent receptor
FH978_RS26345	COG1595	DNA-templated transcription, initiation
FH978_RS26360	COG3969	phosphoadenosine phosphosulfate
FH978_RS26365	COG1475	DNA binding
FH978_RS26385	COG2382	esterase
FH978_RS26420	COG0500	methyltransferase
FH978_RS26535	COG3436	PFAM IS66 Orf2 family protein
FH978_RS26540	COG4372	Transposase
FH978_RS26670	COG4245	von Willebrand factor, type A
FH978_RS26675	COG4245	von Willebrand factor, type A
FH978_RS26685	COG4245	von Willebrand factor, type A
FH978_RS26705	COG1358	cellular component organization or biogenesis
FH978_RS26800	COG0604	alcohol dehydrogenase
FH978_RS26800	COG1028	Short-chain dehydrogenase reductase Sdr
FH978_RS26800	COG3321	synthase
FH978_RS26815	COG1522	sequence-specific DNA binding
FH978_RS26895	COG1956	GAF domain-containing protein
FH978_RS26900	COG1956	GAF domain-containing protein
FH978_RS27015	COG0500	methyltransferase
FH978_RS27030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FH978_RS27040	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FH978_RS27115	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FH978_RS27145	COG0739	heme binding
FH978_RS27160	COG3667	copper resistance
FH978_RS27165	COG2372	response to copper ion
FH978_RS27170	COG1276	copper resistance
FH978_RS27175	COG0745	RESPONSE REGULATOR receiver
FH978_RS27180	COG2205	protein histidine kinase activity
FH978_RS27185	COG0789	Transcriptional regulator
FH978_RS27200	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FH978_RS27290	COG0523	cobalamin synthesis protein
FH978_RS27320	COG0523	cobalamin synthesis protein
FH978_RS27325	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FH978_RS27330	COG0735	belongs to the Fur family