locus-tag	class	description
C2U50_RS00075	COG3039	Transposase
C2U50_RS00130	COG3039	Transposase
C2U50_RS00225	COG3344	reverse transcriptase
C2U50_RS00290	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
C2U50_RS00310	COG4245	von Willebrand factor, type A
C2U50_RS00315	COG4245	von Willebrand factor, type A
C2U50_RS00325	COG4245	von Willebrand factor, type A
C2U50_RS00345	COG1358	cellular component organization or biogenesis
C2U50_RS00440	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2U50_RS00455	COG2801	Transposase and inactivated derivatives
C2U50_RS00510	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2U50_RS00665	COG3550	peptidyl-serine autophosphorylation
C2U50_RS00705	COG2814	Major facilitator Superfamily
C2U50_RS00720	COG3111	PFAM Bacterial OB fold (BOF) protein
C2U50_RS00745	COG3534	alpha-L-arabinofuranosidase
C2U50_RS00750	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2U50_RS00765	COG2376	Dihydroxyacetone kinase
C2U50_RS00770	COG1461	Dihydroxyacetone kinase
C2U50_RS00790	COG2376	Dihydroxyacetone kinase
C2U50_RS00805	COG3775	system Galactitol-specific IIC component
C2U50_RS00810	COG3414	Phosphotransferase system galactitol-specific IIB component
C2U50_RS00820	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2U50_RS00915	COG3039	Transposase
C2U50_RS00960	COG1484	DNA-dependent DNA replication
C2U50_RS01025	COG0633	Ferredoxin
C2U50_RS01260	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2U50_RS01260	COG1199	ATP-dependent helicase activity
C2U50_RS01285	COG5642	Protein of unknown function (DUF2384)
C2U50_RS01290	COG5654	RES domain protein
C2U50_RS01620	COG0789	Transcriptional regulator
C2U50_RS01750	COG3344	reverse transcriptase
C2U50_RS01830	COG1475	DNA binding
C2U50_RS02120	COG0629	single-stranded DNA binding
C2U50_RS02390	COG0789	Transcriptional regulator
C2U50_RS02445	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
C2U50_RS02525	COG3344	reverse transcriptase
C2U50_RS02675	COG0464	growth
C2U50_RS02700	COG2801	Transposase and inactivated derivatives
C2U50_RS02710	COG3111	PFAM Bacterial OB fold (BOF) protein
C2U50_RS02725	COG2814	Major facilitator Superfamily
C2U50_RS02775	COG3077	Addiction module antitoxin, RelB DinJ family
C2U50_RS02780	COG2026	Addiction module toxin, RelE StbE family
C2U50_RS02840	COG5499	transcription regulator containing HTH domain
C2U50_RS03140	COG0789	Transcriptional regulator
C2U50_RS03185	COG4644	lycopene metabolic process
C2U50_RS03265	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2U50_RS03280	COG2801	Transposase and inactivated derivatives
C2U50_RS03330	COG4372	Transposase
C2U50_RS03335	COG3436	PFAM IS66 Orf2 family protein
C2U50_RS03360	COG2205	protein histidine kinase activity
C2U50_RS03365	COG0745	RESPONSE REGULATOR receiver
C2U50_RS03370	COG1276	copper resistance
C2U50_RS03375	COG2372	response to copper ion
C2U50_RS03380	COG3667	copper resistance
C2U50_RS03385	COG2132	Multicopper oxidase
C2U50_RS03395	COG0739	heme binding
C2U50_RS03425	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U50_RS03585	COG3039	Transposase
C2U50_RS03725	COG0789	Transcriptional regulator
C2U50_RS03770	COG4644	lycopene metabolic process
C2U50_RS03780	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2U50_RS03790	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U50_RS03795	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C2U50_RS03795	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U50_RS03795	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U50_RS03810	COG0583	DNA-binding transcription factor activity
C2U50_RS03815	COG0583	DNA-binding transcription factor activity
C2U50_RS03820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2U50_RS03830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2U50_RS03850	COG1609	Transcriptional regulator
C2U50_RS03880	COG1652	LysM domain
C2U50_RS03910	COG0456	acetyltransferase
C2U50_RS03910	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C2U50_RS03920	COG0667	Aldo Keto reductase
C2U50_RS03925	COG0667	Aldo Keto reductase
C2U50_RS03930	COG3386	PFAM SMP-30 Gluconolaconase
C2U50_RS03935	COG0667	Aldo Keto reductase
C2U50_RS04015	COG2801	Transposase and inactivated derivatives
C2U50_RS04025	COG4977	sequence-specific DNA binding
C2U50_RS04035	COG4372	Transposase
C2U50_RS04040	COG3436	PFAM IS66 Orf2 family protein
C2U50_RS04070	COG2819	hydrolase of the alpha beta superfamily
C2U50_RS04075	COG3300	MHYT domain
C2U50_RS04075	COG5001	Diguanylate cyclase
C2U50_RS04110	COG3188	usher protein
C2U50_RS04125	COG1649	PFAM Uncharacterised BCR, COG1649
C2U50_RS04130	COG3550	peptidyl-serine autophosphorylation
C2U50_RS04135	COG1396	sequence-specific DNA binding
C2U50_RS04140	COG2351	hydroxyisourate hydrolase activity
C2U50_RS04145	COG3648	Uricase
C2U50_RS04145	COG3195	allantoin biosynthetic process
C2U50_RS04150	COG2233	PERMEase
C2U50_RS04180	COG2207	Transcriptional regulator
C2U50_RS04195	COG4628	conserved protein (DUF2132)
C2U50_RS04215	COG2011	ABC-type metal ion transport system permease component
C2U50_RS04220	COG2070	2-Nitropropane dioxygenase
C2U50_RS04230	COG0477	Major facilitator Superfamily
C2U50_RS04305	COG2199	diguanylate cyclase activity
C2U50_RS04320	COG1012	belongs to the aldehyde dehydrogenase family
C2U50_RS04325	COG0583	DNA-binding transcription factor activity
C2U50_RS04335	COG0039	L-malate dehydrogenase activity
C2U50_RS04340	COG1349	DNA-binding transcription factor activity
C2U50_RS04345	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C2U50_RS04350	COG3395	kinase activity
C2U50_RS04360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2U50_RS04365	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2U50_RS04370	COG2271	Major facilitator Superfamily
C2U50_RS04395	COG4977	sequence-specific DNA binding
C2U50_RS04405	COG0697	spore germination
C2U50_RS04410	COG2814	Major facilitator Superfamily
C2U50_RS04425	COG1129	ABC transporter
C2U50_RS04440	COG0683	leucine binding
C2U50_RS04445	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2U50_RS04480	COG2223	nitrite transmembrane transporter activity
C2U50_RS04485	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C2U50_RS04500	COG1349	DNA-binding transcription factor activity
C2U50_RS04505	COG2084	Dehydrogenase
C2U50_RS04510	COG3395	kinase activity
C2U50_RS04515	COG0235	Class ii aldolase
C2U50_RS04520	COG3622	Belongs to the hyi family
C2U50_RS04525	COG2610	gluconate transmembrane transporter activity
C2U50_RS04530	COG3708	Transcriptional regulator
C2U50_RS04530	COG2207	Transcriptional regulator
C2U50_RS04545	COG2200	EAL domain
C2U50_RS04550	COG1546	Belongs to the CinA family
C2U50_RS04555	COG0071	Belongs to the small heat shock protein (HSP20) family
C2U50_RS04575	COG2135	peptidase activity
C2U50_RS04580	COG2207	Transcriptional regulator
C2U50_RS04590	COG0339	signal peptide processing
C2U50_RS04595	COG4221	oxidoreductase activity
C2U50_RS04600	COG1802	Transcriptional regulator
C2U50_RS04605	COG0589	response to stress
C2U50_RS04610	COG0246	Mannitol dehydrogenase
C2U50_RS04615	COG2271	Major facilitator Superfamily
C2U50_RS04630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2U50_RS04650	COG0437	4 iron, 4 sulfur cluster binding
C2U50_RS04655	COG3302	dmso reductase anchor subunit
C2U50_RS04670	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C2U50_RS04675	COG1940	carbohydrate kinase activity
C2U50_RS04680	COG0583	DNA-binding transcription factor activity
C2U50_RS04685	COG2814	Major facilitator Superfamily
C2U50_RS04690	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C2U50_RS04700	COG3591	Belongs to the peptidase S1B family
C2U50_RS04720	COG0628	permease
C2U50_RS04750	COG0679	Auxin Efflux Carrier
C2U50_RS04760	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2U50_RS04800	COG3290	protein histidine kinase activity
C2U50_RS04805	COG4565	transcriptional regulatory protein
C2U50_RS04845	COG0392	lysyltransferase activity
C2U50_RS04850	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U50_RS04855	COG3568	Endonuclease Exonuclease Phosphatase
C2U50_RS04870	COG0842	Transport permease protein
C2U50_RS04875	COG0842	Transport permease protein
C2U50_RS04880	COG1131	(ABC) transporter
C2U50_RS04885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U50_RS04910	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2U50_RS04915	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2U50_RS04925	COG0183	Belongs to the thiolase family
C2U50_RS04930	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2U50_RS04940	COG1414	Transcriptional regulator
C2U50_RS04945	COG2840	Smr protein MutS2
C2U50_RS04950	COG0583	DNA-binding transcription factor activity
C2U50_RS04960	COG1473	amidohydrolase
C2U50_RS04965	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C2U50_RS04980	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2U50_RS04995	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C2U50_RS05000	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C2U50_RS05020	COG0531	amino acid
C2U50_RS05030	COG3136	membrane protein required for alginate biosynthesis
C2U50_RS05035	COG0745	RESPONSE REGULATOR receiver
C2U50_RS05045	COG2205	protein histidine kinase activity
C2U50_RS05055	COG0114	fumarate hydratase activity
C2U50_RS05060	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C2U50_RS05060	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C2U50_RS05065	COG1482	cell wall glycoprotein biosynthetic process
C2U50_RS05070	COG5339	Protein conserved in bacteria
C2U50_RS05075	COG1609	Transcriptional regulator
C2U50_RS05080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U50_RS05080	COG1263	PTS System
C2U50_RS05085	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2U50_RS05130	COG3039	Transposase
C2U50_RS05155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U50_RS05155	COG1263	PTS System
C2U50_RS05185	COG2391	methyltransferase activity
C2U50_RS05190	COG0425	Belongs to the sulfur carrier protein TusA family
C2U50_RS05195	COG5562	phage envelope protein
C2U50_RS05200	COG0401	homolog of Blt101
C2U50_RS05205	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2U50_RS05210	COG1012	belongs to the aldehyde dehydrogenase family
C2U50_RS05215	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C2U50_RS05220	COG0477	Major facilitator Superfamily
C2U50_RS05225	COG1113	amino acid transport
C2U50_RS05230	COG2988	succinylglutamate desuccinylase activity
C2U50_RS05235	COG3724	N-succinylarginine dihydrolase activity
C2U50_RS05240	COG1012	belongs to the aldehyde dehydrogenase family
C2U50_RS05245	COG3138	arginine N-succinyltransferase
C2U50_RS05250	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2U50_RS05255	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2U50_RS05260	COG0667	Aldo Keto reductase
C2U50_RS05265	COG0583	DNA-binding transcription factor activity
C2U50_RS05290	COG4122	O-methyltransferase activity
C2U50_RS05295	COG1643	Atp-dependent helicase
C2U50_RS05310	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2U50_RS05315	COG3327	negative regulation of DNA-templated transcription, initiation
C2U50_RS05320	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
C2U50_RS05325	COG0183	Belongs to the thiolase family
C2U50_RS05330	COG2050	protein possibly involved in aromatic compounds catabolism
C2U50_RS05335	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U50_RS05340	COG1024	Enoyl-CoA hydratase
C2U50_RS05345	COG1024	Enoyl-CoA hydratase
C2U50_RS05350	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U50_RS05355	COG2151	metal-sulfur cluster biosynthetic enzyme
C2U50_RS05360	COG3396	Phenylacetate-CoA oxygenase
C2U50_RS05365	COG3460	Phenylacetate-CoA oxygenase
C2U50_RS05370	COG3396	Phenylacetate-CoA oxygenase
C2U50_RS05375	COG2030	dehydratase
C2U50_RS05375	COG1012	belongs to the aldehyde dehydrogenase family
C2U50_RS05420	COG2072	flavoprotein involved in K transport
C2U50_RS05425	COG0583	DNA-binding transcription factor activity
C2U50_RS05435	COG1126	abc transporter atp-binding protein
C2U50_RS05445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U50_RS05460	COG1012	belongs to the aldehyde dehydrogenase family
C2U50_RS05465	COG2207	Transcriptional regulator
C2U50_RS05470	COG3784	Protein of unknown function (DUF1318)
C2U50_RS05480	COG2911	Protein conserved in bacteria
C2U50_RS05485	COG0586	Pfam SNARE associated Golgi protein
C2U50_RS05490	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2U50_RS05495	COG3187	Heat shock protein
C2U50_RS05500	COG3042	response to heat
C2U50_RS05510	COG0674	pyruvate-flavodoxin oxidoreductase activity
C2U50_RS05510	COG1013	pyruvate-flavodoxin oxidoreductase activity
C2U50_RS05510	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C2U50_RS05510	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U50_RS05515	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2U50_RS05525	COG0589	response to stress
C2U50_RS05535	COG0513	Belongs to the DEAD box helicase family
C2U50_RS05555	COG1349	DNA-binding transcription factor activity
C2U50_RS05560	COG0673	inositol 2-dehydrogenase activity
C2U50_RS05575	COG1113	amino acid transport
C2U50_RS05580	COG1522	sequence-specific DNA binding
C2U50_RS05590	COG1448	Aminotransferase
C2U50_RS05595	COG2011	ABC-type metal ion transport system permease component
C2U50_RS05605	COG1464	Belongs to the NlpA lipoprotein family
C2U50_RS05610	COG0436	Aminotransferase
C2U50_RS05615	COG0604	alcohol dehydrogenase
C2U50_RS05640	COG0583	DNA-binding transcription factor activity
C2U50_RS05660	COG1028	Short-chain dehydrogenase reductase Sdr
C2U50_RS05665	COG1309	transcriptional regulator
C2U50_RS05670	COG1028	Short-chain dehydrogenase reductase Sdr
C2U50_RS05785	COG2885	chlorophyll binding
C2U50_RS05980	COG3179	chitinase
C2U50_RS06010	COG0484	heat shock protein binding
C2U50_RS06090	COG0582	viral genome integration into host DNA
C2U50_RS06095	COG0693	protein deglycase activity
C2U50_RS06100	COG1078	dGTPase activity
C2U50_RS06105	COG1028	Short-chain dehydrogenase reductase Sdr
C2U50_RS06110	COG0583	DNA-binding transcription factor activity
C2U50_RS06130	COG0656	L-ascorbic acid biosynthetic process
C2U50_RS06160	COG4166	transmembrane transport
C2U50_RS06165	COG2866	Carboxypeptidase
C2U50_RS06170	COG4948	Mandelate Racemase Muconate Lactonizing
C2U50_RS06175	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C2U50_RS06180	COG3180	Ammonia monooxygenase
C2U50_RS06190	COG1486	melibiose metabolic process
C2U50_RS06195	COG0583	DNA-binding transcription factor activity
C2U50_RS06205	COG3106	COG3106 Predicted ATPase
C2U50_RS06215	COG1983	PspC domain protein
C2U50_RS06225	COG1842	Phage shock protein A
C2U50_RS06230	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2U50_RS06240	COG1473	amidohydrolase
C2U50_RS06255	COG0702	epimerase
C2U50_RS06270	COG2135	peptidase activity
C2U50_RS06275	COG2135	peptidase activity
C2U50_RS06285	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2U50_RS06290	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2U50_RS06295	COG3344	reverse transcriptase
C2U50_RS06355	COG1196	nuclear chromosome segregation
C2U50_RS06440	COG5484	DNA packaging
C2U50_RS06440	COG3728	DNA packaging
C2U50_RS06490	COG0484	heat shock protein binding
C2U50_RS06575	COG1484	DNA-dependent DNA replication
C2U50_RS06620	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2U50_RS06660	COG4171	peptide transport system, permease
C2U50_RS06675	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2U50_RS06685	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2U50_RS06690	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2U50_RS06690	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2U50_RS06705	COG1349	DNA-binding transcription factor activity
C2U50_RS06715	COG0023	Translation Initiation Factor
C2U50_RS06725	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C2U50_RS06730	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
C2U50_RS06735	COG0671	phosphoesterase, PA-phosphatase related
C2U50_RS06745	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C2U50_RS06775	COG0616	signal peptide processing
C2U50_RS06785	COG1028	Short-chain dehydrogenase reductase Sdr
C2U50_RS06790	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
C2U50_RS06800	COG0583	DNA-binding transcription factor activity
C2U50_RS06810	COG0009	L-threonylcarbamoyladenylate synthase
C2U50_RS06820	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2U50_RS06825	COG0512	Glutamine amidotransferase of anthranilate synthase
C2U50_RS06825	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2U50_RS06830	COG0135	phosphoribosylanthranilate isomerase activity
C2U50_RS06830	COG0134	indole-3-glycerol-phosphate synthase activity
C2U50_RS06865	COG4774	siderophore transport
C2U50_RS06875	COG3047	cAMP biosynthetic process
C2U50_RS06880	COG0727	PFAM Uncharacterised protein family (UPF0153)
C2U50_RS06910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U50_RS06915	COG1028	Short-chain dehydrogenase reductase Sdr
C2U50_RS06920	COG1988	membrane-bound metal-dependent
C2U50_RS06925	COG1823	symporter activity
C2U50_RS06935	COG0753	catalase activity
C2U50_RS06945	COG1486	melibiose metabolic process
C2U50_RS06950	COG2169	Transcriptional regulator
C2U50_RS06950	COG1917	Cupin 2, conserved barrel domain protein
C2U50_RS06955	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2U50_RS06960	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2U50_RS06965	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2U50_RS06970	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U50_RS06980	COG0322	excinuclease ABC activity
C2U50_RS06985	COG3678	ATP-independent chaperone mediated protein folding
C2U50_RS06995	COG3724	N-succinylarginine dihydrolase activity
C2U50_RS07005	COG3138	arginine N-succinyltransferase
C2U50_RS07015	COG0708	Exodeoxyribonuclease III
C2U50_RS07020	COG0398	Pfam SNARE associated Golgi protein
C2U50_RS07025	COG0398	Pfam SNARE associated Golgi protein
C2U50_RS07030	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2U50_RS07035	COG4134	Bacterial extracellular solute-binding protein
C2U50_RS07040	COG4135	transport system, permease component
C2U50_RS07045	COG4136	ATPase activity
C2U50_RS07055	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2U50_RS07060	COG0494	nUDIX hydrolase
C2U50_RS07065	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2U50_RS07070	COG0604	alcohol dehydrogenase
C2U50_RS07070	COG1028	Short-chain dehydrogenase reductase Sdr
C2U50_RS07070	COG3321	synthase
C2U50_RS07075	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2U50_RS07080	COG0709	Synthesizes selenophosphate from selenide and ATP
C2U50_RS07100	COG0778	Nitroreductase
C2U50_RS07105	COG0616	signal peptide processing
C2U50_RS07110	COG0252	asparaginase activity
C2U50_RS07115	COG1335	isochorismatase
C2U50_RS07130	COG3139	Protein of unknown function (DUF1315)
C2U50_RS07150	COG0656	L-ascorbic acid biosynthetic process
C2U50_RS07155	COG3713	MltA-interacting MipA family protein
C2U50_RS07160	COG2766	serine protein kinase
C2U50_RS07175	COG0386	Belongs to the glutathione peroxidase family
C2U50_RS07195	COG1028	Short-chain dehydrogenase reductase Sdr
C2U50_RS07200	COG0583	DNA-binding transcription factor activity
C2U50_RS07205	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2U50_RS07210	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2U50_RS07215	COG3344	reverse transcriptase
C2U50_RS07230	COG0859	PFAM glycosyl transferase family 9
C2U50_RS07235	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2U50_RS07245	COG2207	Transcriptional regulator
C2U50_RS07250	COG2807	transmembrane transport
C2U50_RS07255	COG0504	CTP synthase activity
C2U50_RS07260	COG1683	Conserved Protein
C2U50_RS07265	COG3189	MarR family transcriptional regulator
C2U50_RS07270	COG3042	response to heat
C2U50_RS07275	COG2203	Gaf domain
C2U50_RS07275	COG2199	diguanylate cyclase activity
C2U50_RS07295	COG3182	Iron-regulated membrane protein
C2U50_RS07305	COG1560	Kdo2-lipid A biosynthetic process
C2U50_RS07320	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C2U50_RS07325	COG3706	GGDEF domain
C2U50_RS07330	COG0583	DNA-binding transcription factor activity
C2U50_RS07335	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C2U50_RS07360	COG1294	oxidase, subunit
C2U50_RS07365	COG1271	oxidase subunit
C2U50_RS07370	COG3546	catalase activity
C2U50_RS07375	COG3685	Protein conserved in bacteria
C2U50_RS07380	COG3685	Protein conserved in bacteria
C2U50_RS07385	COG3729	General stress protein
C2U50_RS07390	COG1063	alcohol dehydrogenase
C2U50_RS07395	COG3813	Protein conserved in bacteria
C2U50_RS07415	COG0640	Transcriptional regulator
C2U50_RS07445	COG0582	viral genome integration into host DNA
C2U50_RS07485	COG1476	TRANSCRIPTIONal
C2U50_RS07545	COG0628	permease
C2U50_RS07560	COG0659	secondary active sulfate transmembrane transporter activity
C2U50_RS07565	COG2239	Acts as a magnesium transporter
C2U50_RS07570	COG4615	Cyclic peptide transporter
C2U50_RS07575	COG3145	DNA-N1-methyladenine dioxygenase activity
C2U50_RS07580	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2U50_RS07580	COG2169	Transcriptional regulator
C2U50_RS07595	COG2198	Histidine kinase
C2U50_RS07595	COG0642	Histidine kinase
C2U50_RS07605	COG2205	protein histidine kinase activity
C2U50_RS07605	COG0784	Response regulator, receiver
C2U50_RS07635	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U50_RS07650	COG2271	Major facilitator Superfamily
C2U50_RS07655	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C2U50_RS07665	COG0247	lactate metabolic process
C2U50_RS07675	COG2271	Major facilitator Superfamily
C2U50_RS07685	COG1414	Transcriptional regulator
C2U50_RS07700	COG5464	transposase or invertase
C2U50_RS07710	COG0318	PFAM AMP-dependent synthetase and ligase
C2U50_RS07735	COG1169	isochorismate synthase
C2U50_RS07740	COG2153	protein acetylation
C2U50_RS07755	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U50_RS07760	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2U50_RS07770	COG0839	Belongs to the complex I subunit 6 family
C2U50_RS07825	COG0583	DNA-binding transcription factor activity
C2U50_RS07830	COG0436	Aminotransferase
C2U50_RS07840	COG0490	domain, Protein
C2U50_RS07840	COG0471	metal ion transport
C2U50_RS07845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U50_RS07865	COG0280	phosphate acetyltransferase
C2U50_RS07865	COG0857	belongs to the CobB CobQ family
C2U50_RS07870	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C2U50_RS07875	COG0622	Phosphoesterase
C2U50_RS07880	COG0625	glutathione transferase activity
C2U50_RS07885	COG0625	glutathione transferase activity
C2U50_RS07890	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C2U50_RS07895	COG1090	epimerase
C2U50_RS07905	COG4598	ABC transporter
C2U50_RS07910	COG4160	amino acid transport
C2U50_RS07930	COG0163	prenyltransferase activity
C2U50_RS07935	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C2U50_RS07940	COG1286	toxin biosynthetic process
C2U50_RS07945	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
C2U50_RS07950	COG0285	dihydrofolate synthase activity
C2U50_RS07960	COG0586	Pfam SNARE associated Golgi protein
C2U50_RS07970	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2U50_RS07990	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2U50_RS08005	COG3101	peptidyl-lysine hydroxylation
C2U50_RS08010	COG0730	response to heat
C2U50_RS08035	COG2062	phosphohistidine phosphatase, SixA
C2U50_RS08050	COG3691	Protein conserved in bacteria
C2U50_RS08065	COG2853	Lipoprotein
C2U50_RS08070	COG2116	formate transmembrane transporter activity
C2U50_RS08090	COG0583	DNA-binding transcription factor activity
C2U50_RS08095	COG0590	tRNA wobble adenosine to inosine editing
C2U50_RS08100	COG2807	transmembrane transport
C2U50_RS08110	COG0436	Aminotransferase
C2U50_RS08120	COG3275	phosphorelay sensor kinase activity
C2U50_RS08125	COG3279	Response regulator of the LytR AlgR family
C2U50_RS08140	COG3961	Belongs to the TPP enzyme family
C2U50_RS08145	COG0667	Aldo Keto reductase
C2U50_RS08160	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2U50_RS08165	COG2200	EAL domain
C2U50_RS08165	COG2199	diguanylate cyclase activity
C2U50_RS08180	COG3415	Transposase
C2U50_RS08185	COG3415	Transposase
C2U50_RS08220	COG0583	DNA-binding transcription factor activity
C2U50_RS08225	COG0385	Bile acid
C2U50_RS08230	COG3530	Putative quorum-sensing-regulated virulence factor
C2U50_RS08250	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2U50_RS08285	COG4319	ketosteroid isomerase
C2U50_RS08295	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C2U50_RS08300	COG4208	sulfate ABC transporter
C2U50_RS08305	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C2U50_RS08310	COG4150	thiosulfate binding
C2U50_RS08320	COG2837	iron assimilation
C2U50_RS08340	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2U50_RS08430	COG4810	utilization protein
C2U50_RS08440	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2U50_RS08445	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2U50_RS08450	COG5342	invasion associated locus B
C2U50_RS08460	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2U50_RS08460	COG0493	'glutamate synthase
C2U50_RS08470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U50_RS08480	COG1393	Belongs to the ArsC family
C2U50_RS08495	COG0400	carboxylic ester hydrolase activity
C2U50_RS08500	COG1444	tRNA N-acetyltransferase activity
C2U50_RS08505	COG2321	neutral zinc metallopeptidase
C2U50_RS08515	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C2U50_RS08525	COG2716	regulation of RNA biosynthetic process
C2U50_RS08530	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C2U50_RS08535	COG0628	permease
C2U50_RS08540	COG4783	chaperone-mediated protein folding
C2U50_RS08545	COG1393	Belongs to the ArsC family
C2U50_RS08560	COG2233	PERMEase
C2U50_RS08570	COG2723	6-phospho-beta-galactosidase activity
C2U50_RS08585	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C2U50_RS08600	COG2200	EAL domain
C2U50_RS08620	COG0641	radical SAM
C2U50_RS08625	COG3119	arylsulfatase activity
C2U50_RS08635	COG0516	GMP reductase activity
C2U50_RS08635	COG0517	IMP dehydrogenase activity
C2U50_RS08645	COG1645	bacterial-type flagellum-dependent swarming motility
C2U50_RS08665	COG2976	Protein conserved in bacteria
C2U50_RS08700	COG4953	penicillin-binding protein 1C
C2U50_RS08705	COG2373	Large extracellular alpha-helical protein
C2U50_RS08710	COG2897	thiosulfate sulfurtransferase activity
C2U50_RS08730	COG2975	iron-sulfur cluster assembly
C2U50_RS08735	COG0633	Ferredoxin
C2U50_RS08755	COG0822	iron-sulfur transferase activity
C2U50_RS08785	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
C2U50_RS08790	COG3683	transport system, periplasmic component
C2U50_RS08795	COG3711	transcriptional antiterminator
C2U50_RS08800	COG2814	Major facilitator Superfamily
C2U50_RS08805	COG2017	converts alpha-aldose to the beta-anomer
C2U50_RS08810	COG0477	Major facilitator Superfamily
C2U50_RS08810	COG2814	Major facilitator Superfamily
C2U50_RS08815	COG0457	Tetratricopeptide repeat
C2U50_RS08820	COG1940	carbohydrate kinase activity
C2U50_RS08825	COG2259	Doxx family
C2U50_RS08840	COG1017	nitric oxide dioxygenase activity
C2U50_RS08840	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U50_RS08845	COG0347	Belongs to the P(II) protein family
C2U50_RS08850	COG2204	response regulator
C2U50_RS08855	COG3170	Tfp pilus assembly protein FimV
C2U50_RS08860	COG2205	protein histidine kinase activity
C2U50_RS08865	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2U50_RS08865	COG0047	phosphoribosylformylglycinamidine synthase activity
C2U50_RS08880	COG0560	Phosphoserine phosphatase
C2U50_RS08885	COG1737	Transcriptional regulator
C2U50_RS08890	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2U50_RS08900	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C2U50_RS08920	COG0681	Belongs to the peptidase S26 family
C2U50_RS08945	COG3344	reverse transcriptase
C2U50_RS09000	COG1196	nuclear chromosome segregation
C2U50_RS09085	COG5484	DNA packaging
C2U50_RS09085	COG3728	DNA packaging
C2U50_RS09110	COG3179	chitinase
C2U50_RS09125	COG0484	heat shock protein binding
C2U50_RS09130	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
C2U50_RS09195	COG1484	DNA-dependent DNA replication
C2U50_RS09250	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2U50_RS09285	COG3086	response to oxidative stress
C2U50_RS09290	COG3026	antisigma factor binding
C2U50_RS09295	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
C2U50_RS09305	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C2U50_RS09315	COG0513	Belongs to the DEAD box helicase family
C2U50_RS09330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2U50_RS09335	COG3118	belongs to the thioredoxin family
C2U50_RS09340	COG3148	PFAM DTW domain containing protein
C2U50_RS09350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U50_RS09355	COG5544	Lipoprotein
C2U50_RS09360	COG0477	Major facilitator Superfamily
C2U50_RS09385	COG0542	response to heat
C2U50_RS09400	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U50_RS09405	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C2U50_RS09415	COG1605	Chorismate mutase
C2U50_RS09415	COG0077	Prephenate dehydratase
C2U50_RS09425	COG1605	Chorismate mutase
C2U50_RS09425	COG0287	Prephenate dehydrogenase
C2U50_RS09430	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U50_RS09440	COG2199	diguanylate cyclase activity
C2U50_RS09445	COG2885	chlorophyll binding
C2U50_RS09480	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C2U50_RS09485	COG4137	Cytochrome C assembly protein
C2U50_RS09490	COG4536	flavin adenine dinucleotide binding
C2U50_RS09510	COG0497	DNA recombination
C2U50_RS09525	COG2867	negative regulation of translational initiation
C2U50_RS09545	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2U50_RS09650	COG1802	Transcriptional regulator
C2U50_RS09650	COG4626	Terminase
C2U50_RS09705	COG3179	chitinase
C2U50_RS09820	COG0582	viral genome integration into host DNA
C2U50_RS09830	COG0582	viral genome integration into host DNA
C2U50_RS09840	COG1204	response to ionizing radiation
C2U50_RS09845	COG3039	Transposase
C2U50_RS09910	COG4916	TIR domain
C2U50_RS09935	COG2207	Transcriptional regulator
C2U50_RS09935	COG3708	Transcriptional regulator
C2U50_RS09940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U50_RS09975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U50_RS09985	COG0235	Class ii aldolase
C2U50_RS09995	COG1028	Short-chain dehydrogenase reductase Sdr
C2U50_RS10010	COG2197	response regulator
C2U50_RS10015	COG3539	Fimbrial protein
C2U50_RS10025	COG3188	usher protein
C2U50_RS10045	COG3121	Chaperone
C2U50_RS10050	COG3539	Fimbrial protein
C2U50_RS10060	COG3284	Transcriptional regulator
C2U50_RS10065	COG0583	DNA-binding transcription factor activity
C2U50_RS10075	COG0640	Transcriptional regulator
C2U50_RS10080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2U50_RS10095	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2U50_RS10120	COG4575	ribosome binding
C2U50_RS10125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U50_RS10130	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2U50_RS10135	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C2U50_RS10145	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2U50_RS10160	COG4176	ABC-type proline glycine betaine transport system permease component
C2U50_RS10170	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C2U50_RS10180	COG1846	Transcriptional regulator
C2U50_RS10185	COG1566	PFAM secretion protein HlyD family protein
C2U50_RS10190	COG2814	Major facilitator Superfamily
C2U50_RS10195	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2U50_RS10215	COG1238	metal cluster binding
C2U50_RS10220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U50_RS10225	COG2823	Periplasmic or secreted lipoprotein
C2U50_RS10255	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C2U50_RS10280	COG1546	Belongs to the CinA family
C2U50_RS10290	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2U50_RS10295	COG1121	(ABC) transporter
C2U50_RS10305	COG2951	lytic endotransglycosylase activity
C2U50_RS10310	COG3730	PTS system glucitol sorbitol-specific
C2U50_RS10315	COG3732	PTS system glucitol sorbitol-specific
C2U50_RS10325	COG1028	Short-chain dehydrogenase reductase Sdr
C2U50_RS10330	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U50_RS10335	COG1349	DNA-binding transcription factor activity
C2U50_RS10365	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
C2U50_RS10370	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C2U50_RS10375	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2U50_RS10380	COG1609	Transcriptional regulator
C2U50_RS10385	COG1263	PTS System
C2U50_RS10385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U50_RS10390	COG2723	6-phospho-beta-galactosidase activity
C2U50_RS10400	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C2U50_RS10410	COG3260	NADH ubiquinone oxidoreductase 20
C2U50_RS10415	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U50_RS10420	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
C2U50_RS10420	COG3261	NADH dehydrogenase
C2U50_RS10425	COG0650	Formate hydrogenlyase subunit 4
C2U50_RS10430	COG0651	ATP synthesis coupled electron transport
C2U50_RS10435	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2U50_RS10455	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C2U50_RS10460	COG0298	carbon dioxide binding
C2U50_RS10465	COG0409	Hydrogenase expression formation protein
C2U50_RS10470	COG0309	Hydrogenase expression formation protein (HypE)
C2U50_RS10480	COG2723	6-phospho-beta-galactosidase activity
C2U50_RS10490	COG4580	involved in the transport of maltose and maltodextrins
C2U50_RS10500	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2U50_RS10505	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2U50_RS10510	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2U50_RS10515	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2U50_RS10520	COG1940	carbohydrate kinase activity
C2U50_RS10525	COG1609	Transcriptional regulator
C2U50_RS10530	COG0803	Belongs to the bacterial solute-binding protein 9 family
C2U50_RS10535	COG1121	(ABC) transporter
C2U50_RS10540	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2U50_RS10545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2U50_RS10560	COG0679	Auxin Efflux Carrier
C2U50_RS10580	COG3720	iron ion transport
C2U50_RS10585	COG4558	Periplasmic binding protein
C2U50_RS10590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U50_RS10635	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C2U50_RS10640	COG0163	prenyltransferase activity
C2U50_RS10665	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2U50_RS10670	COG1388	LysM domain
C2U50_RS10670	COG4942	peptidase
C2U50_RS10730	COG2234	aminopeptidase activity
C2U50_RS10750	COG0720	synthase
C2U50_RS10755	COG0602	queuosine metabolic process
C2U50_RS10775	COG3956	TIGRFAM MazG family protein
C2U50_RS10780	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2U50_RS10790	COG2205	protein histidine kinase activity
C2U50_RS10790	COG4999	Histidine kinase
C2U50_RS10790	COG3437	response regulator, receiver
C2U50_RS10790	COG3850	Histidine kinase
C2U50_RS10795	COG1929	Belongs to the glycerate kinase type-1 family
C2U50_RS10800	COG4948	Mandelate Racemase Muconate Lactonizing
C2U50_RS10805	COG4948	Mandelate Racemase Muconate Lactonizing
C2U50_RS10810	COG2271	Major facilitator Superfamily
C2U50_RS10815	COG0716	FMN binding
C2U50_RS10820	COG0564	pseudouridine synthase activity
C2U50_RS10825	COG3098	single-species biofilm formation
C2U50_RS10840	COG1611	Belongs to the LOG family
C2U50_RS10845	COG0814	amino acid
C2U50_RS10850	COG1760	l-serine dehydratase
C2U50_RS10855	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2U50_RS10865	COG0477	Major facilitator Superfamily
C2U50_RS10875	COG1464	Belongs to the NlpA lipoprotein family
C2U50_RS10880	COG2011	ABC-type metal ion transport system permease component
C2U50_RS10885	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2U50_RS10900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U50_RS10915	COG1454	alcohol dehydrogenase
C2U50_RS10920	COG0235	Class ii aldolase
C2U50_RS10925	COG0738	Major facilitator superfamily
C2U50_RS10945	COG1349	DNA-binding transcription factor activity
C2U50_RS10955	COG2363	Small membrane protein
C2U50_RS10960	COG0583	DNA-binding transcription factor activity
C2U50_RS10970	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2U50_RS10975	COG2166	iron-sulfur cluster assembly
C2U50_RS10980	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C2U50_RS10985	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C2U50_RS11150	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
C2U50_RS11180	COG1012	belongs to the aldehyde dehydrogenase family
C2U50_RS11180	COG1454	alcohol dehydrogenase
C2U50_RS11185	COG4656	Part of a membrane complex involved in electron transport
C2U50_RS11215	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C2U50_RS11220	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2U50_RS11225	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C2U50_RS11225	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C2U50_RS11235	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2U50_RS11240	COG1074	ATP-dependent DNA helicase activity
C2U50_RS11245	COG1025	Belongs to the peptidase M16 family
C2U50_RS11250	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C2U50_RS11255	COG4967	type IV pilus modification protein PilV
C2U50_RS11265	COG4795	General secretion pathway protein
C2U50_RS11300	COG0861	Integral membrane protein TerC family
C2U50_RS11310	COG0667	Aldo Keto reductase
C2U50_RS11335	COG1609	Transcriptional regulator
C2U50_RS11345	COG2186	Transcriptional regulator
C2U50_RS11350	COG2723	6-phospho-beta-galactosidase activity
C2U50_RS11355	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2U50_RS11360	COG1609	Transcriptional regulator
C2U50_RS11370	COG0583	DNA-binding transcription factor activity
C2U50_RS11375	COG1794	racemase activity, acting on amino acids and derivatives
C2U50_RS11380	COG1917	Cupin 2, conserved barrel domain protein
C2U50_RS11385	COG1175	transmembrane transport
C2U50_RS11390	COG0395	ABC-type sugar transport system, permease component
C2U50_RS11395	COG3842	ATPase activity
C2U50_RS11425	COG2814	Major facilitator Superfamily
C2U50_RS11430	COG1028	Short-chain dehydrogenase reductase Sdr
C2U50_RS11435	COG0823	Involved in the tonB-independent uptake of proteins
C2U50_RS11445	COG0183	Belongs to the thiolase family
C2U50_RS11460	COG0814	amino acid
C2U50_RS11465	COG0667	Aldo Keto reductase
C2U50_RS11515	COG0697	spore germination
C2U50_RS11520	COG1846	Transcriptional regulator
C2U50_RS11525	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
C2U50_RS11540	COG0582	viral genome integration into host DNA
C2U50_RS11545	COG4974	Belongs to the 'phage' integrase family
C2U50_RS11555	COG3539	Fimbrial protein
C2U50_RS11560	COG3121	Chaperone
C2U50_RS11565	COG3188	usher protein
C2U50_RS11570	COG3539	Fimbrial protein
C2U50_RS11575	COG3539	Fimbrial protein
C2U50_RS11580	COG3539	Fimbrial protein
C2U50_RS11590	COG2388	GCN5-related N-acetyl-transferase
C2U50_RS11595	COG3592	Divergent 4Fe-4S mono-cluster
C2U50_RS11610	COG1289	transmembrane transporter activity
C2U50_RS11615	COG1538	Outer membrane efflux protein
C2U50_RS11630	COG1393	Belongs to the ArsC family
C2U50_RS11635	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2U50_RS11675	COG0667	Aldo Keto reductase
C2U50_RS11690	COG2814	Major facilitator Superfamily
C2U50_RS11700	COG4942	peptidase
C2U50_RS11725	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C2U50_RS11735	COG4974	Belongs to the 'phage' integrase family
C2U50_RS11740	COG0716	FMN binding
C2U50_RS11750	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C2U50_RS11760	COG1272	protein, Hemolysin III
C2U50_RS11770	COG1737	Transcriptional regulator
C2U50_RS11775	COG2723	6-phospho-beta-galactosidase activity
C2U50_RS11795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2U50_RS11805	COG1028	Short-chain dehydrogenase reductase Sdr
C2U50_RS11825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U50_RS11830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U50_RS11835	COG0006	proline dipeptidase activity
C2U50_RS11855	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C2U50_RS11860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2U50_RS11875	COG2968	Membrane
C2U50_RS11885	COG0668	transmembrane transport
C2U50_RS11890	COG0191	fructose-bisphosphate aldolase activity
C2U50_RS11905	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2U50_RS11910	COG0501	Belongs to the peptidase M48B family
C2U50_RS11930	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
C2U50_RS11935	COG1028	Short-chain dehydrogenase reductase Sdr
C2U50_RS11940	COG2267	carboxylic ester hydrolase activity
C2U50_RS11965	COG1414	Transcriptional regulator
C2U50_RS11970	COG1028	Short-chain dehydrogenase reductase Sdr
C2U50_RS11985	COG2146	nitrite reductase [NAD(P)H] activity
C2U50_RS12025	COG2814	Major facilitator Superfamily
C2U50_RS12035	COG2356	endonuclease I
C2U50_RS12040	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2U50_RS12045	COG0189	ligase activity
C2U50_RS12065	COG2805	Type II/IV secretion system protein
C2U50_RS12070	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C2U50_RS12075	COG0762	integral membrane protein
C2U50_RS12090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2U50_RS12105	COG4214	carbohydrate transport
C2U50_RS12115	COG3171	Protein conserved in bacteria
C2U50_RS12125	COG1194	a g-specific adenine glycosylase
C2U50_RS12140	COG2211	Major facilitator Superfamily
C2U50_RS12145	COG1982	Orn Lys Arg decarboxylase major
C2U50_RS12155	COG1811	Na channel or pump
C2U50_RS12165	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C2U50_RS12225	COG3423	Transcriptional regulator
C2U50_RS12230	COG1278	Cold shock
C2U50_RS12245	COG3423	Transcriptional regulator
C2U50_RS12295	COG3039	Transposase
C2U50_RS12480	COG0626	cystathionine gamma-synthase activity
C2U50_RS12485	COG0583	DNA-binding transcription factor activity
C2U50_RS12505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U50_RS12510	COG0754	glutathionylspermidine amidase activity
C2U50_RS12520	COG0625	glutathione transferase activity
C2U50_RS12545	COG2211	Major facilitator Superfamily
C2U50_RS12550	COG0848	biopolymer transport protein
C2U50_RS12565	COG0626	cystathionine gamma-synthase activity
C2U50_RS12570	COG0586	Pfam SNARE associated Golgi protein
C2U50_RS12575	COG2207	Transcriptional regulator
C2U50_RS12580	COG1979	alcohol dehydrogenase
C2U50_RS12585	COG0656	L-ascorbic acid biosynthetic process
C2U50_RS12595	COG1032	radical SAM domain protein
C2U50_RS12600	COG2132	Multicopper oxidase
C2U50_RS12605	COG0204	Acyl-transferase
C2U50_RS12610	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C2U50_RS12615	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
C2U50_RS12620	COG3111	PFAM Bacterial OB fold (BOF) protein
C2U50_RS12630	COG0642	Histidine kinase
C2U50_RS12635	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2U50_RS12640	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C2U50_RS12650	COG3150	esterase
C2U50_RS12655	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C2U50_RS12660	COG3151	Protein conserved in bacteria
C2U50_RS12665	COG0494	nUDIX hydrolase
C2U50_RS12680	COG0754	glutathionylspermidine amidase activity
C2U50_RS12685	COG3384	dioxygenase
C2U50_RS12700	COG2960	long-chain fatty acid transporting porin activity
C2U50_RS12720	COG3025	triphosphatase activity
C2U50_RS12725	COG4991	sh3 domain protein
C2U50_RS12740	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C2U50_RS12805	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C2U50_RS12810	COG0358	DNA primase activity
C2U50_RS12815	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2U50_RS12840	COG2197	response regulator
C2U50_RS12845	COG0784	Response regulator, receiver
C2U50_RS12845	COG2205	protein histidine kinase activity
C2U50_RS12845	COG2198	Histidine kinase
C2U50_RS12845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U50_RS12855	COG3247	response to pH
C2U50_RS12900	COG3039	Transposase
C2U50_RS12940	COG2376	Dihydroxyacetone kinase
C2U50_RS12945	COG1461	Dihydroxyacetone kinase
C2U50_RS12960	COG2375	cellular response to nickel ion
C2U50_RS12965	COG1695	Transcriptional regulator
C2U50_RS13020	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U50_RS13020	COG1902	pentaerythritol trinitrate reductase activity
C2U50_RS13040	COG1451	nucleotide metabolic process
C2U50_RS13045	COG0673	inositol 2-dehydrogenase activity
C2U50_RS13050	COG0861	Integral membrane protein TerC family
C2U50_RS13065	COG2721	sulfolactate sulfo-lyase activity
C2U50_RS13075	COG2271	Major facilitator Superfamily
C2U50_RS13080	COG2186	Transcriptional regulator
C2U50_RS13090	COG0586	Pfam SNARE associated Golgi protein
C2U50_RS13100	COG1422	Protein of unknown function (DUF1090)
C2U50_RS13105	COG4575	ribosome binding
C2U50_RS13110	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
C2U50_RS13120	COG2259	Doxx family
C2U50_RS13125	COG0435	Glutathione S-transferase
C2U50_RS13130	COG3152	Membrane
C2U50_RS13135	COG0583	DNA-binding transcription factor activity
C2U50_RS13140	COG1741	Belongs to the pirin family
C2U50_RS13165	COG1929	Belongs to the glycerate kinase type-1 family
C2U50_RS13170	COG2084	Dehydrogenase
C2U50_RS13180	COG2271	Major facilitator Superfamily
C2U50_RS13185	COG2721	sulfolactate sulfo-lyase activity
C2U50_RS13190	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C2U50_RS13210	COG2823	Periplasmic or secreted lipoprotein
C2U50_RS13215	COG0701	Predicted permease
C2U50_RS13220	COG0702	epimerase
C2U50_RS13225	COG0693	protein deglycase activity
C2U50_RS13240	COG3153	acetyltransferase
C2U50_RS13245	COG3154	lipid carrier protein
C2U50_RS13250	COG0826	peptidase U32
C2U50_RS13255	COG0826	peptidase U32
C2U50_RS13260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U50_RS13265	COG0814	amino acid
C2U50_RS13315	COG0195	Participates in both transcription termination and antitermination
C2U50_RS13355	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2U50_RS13365	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C2U50_RS13370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2U50_RS13380	COG1534	Rna-binding protein
C2U50_RS13390	COG2027	D-alanyl-D-alanine carboxypeptidase
C2U50_RS13400	COG0697	spore germination
C2U50_RS13415	COG0142	geranyltranstransferase activity
C2U50_RS13420	COG3423	Transcriptional regulator
C2U50_RS13430	COG5007	Belongs to the BolA IbaG family
C2U50_RS13435	COG3113	response to antibiotic
C2U50_RS13440	COG2854	intermembrane phospholipid transfer
C2U50_RS13445	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2U50_RS13450	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C2U50_RS13455	COG1127	ABC transporter
C2U50_RS13465	COG0530	calcium, potassium:sodium antiporter activity
C2U50_RS13475	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C2U50_RS13480	COG3117	lipopolysaccharide transmembrane transporter activity
C2U50_RS13485	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C2U50_RS13490	COG1137	ATPase activity
C2U50_RS13495	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C2U50_RS13500	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C2U50_RS13505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U50_RS13515	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U50_RS13520	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2U50_RS13525	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C2U50_RS13530	COG5002	protein histidine kinase activity
C2U50_RS13530	COG2198	Histidine kinase
C2U50_RS13530	COG0784	Response regulator, receiver
C2U50_RS13535	COG1312	Catalyzes the dehydration of D-mannonate
C2U50_RS13540	COG1063	alcohol dehydrogenase
C2U50_RS13545	COG2271	Major facilitator Superfamily
C2U50_RS13550	COG1242	4 iron, 4 sulfur cluster binding
C2U50_RS13560	COG0069	glutamate synthase activity
C2U50_RS13560	COG0067	glutamate synthase
C2U50_RS13560	COG0070	glutamate synthase
C2U50_RS13565	COG0493	'glutamate synthase
C2U50_RS13575	COG2969	positive regulation of protein catabolic process
C2U50_RS13580	COG0625	glutathione transferase activity
C2U50_RS13600	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C2U50_RS13605	COG3105	Protein conserved in bacteria
C2U50_RS13610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U50_RS13615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U50_RS13640	COG2732	(Barnase) inhibitor
C2U50_RS13645	COG1289	transmembrane transporter activity
C2U50_RS13660	COG0583	DNA-binding transcription factor activity
C2U50_RS13665	COG0312	modulator of DNA gyrase
C2U50_RS13670	COG3164	Protein of unknown function
C2U50_RS13675	COG1530	ribonuclease E activity
C2U50_RS13685	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C2U50_RS13690	COG1792	Involved in formation and maintenance of cell shape
C2U50_RS13695	COG1077	Cell shape determining protein MreB Mrl
C2U50_RS13705	COG2200	EAL domain
C2U50_RS13705	COG2199	diguanylate cyclase activity
C2U50_RS13735	COG0511	ligase activity, forming carbon-carbon bonds
C2U50_RS13740	COG0439	Biotin carboxylase
C2U50_RS13745	COG3924	membrane
C2U50_RS13750	COG4145	pantothenate transmembrane transporter activity
C2U50_RS13775	COG1309	transcriptional regulator
C2U50_RS13780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U50_RS13785	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U50_RS13825	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2U50_RS13845	COG0551	DNA topoisomerase type I activity
C2U50_RS13855	COG0758	DNA mediated transformation
C2U50_RS13885	COG3036	rescue of stalled ribosome
C2U50_RS13890	COG0789	Transcriptional regulator
C2U50_RS13905	COG0202	RNA polymerase activity
C2U50_RS13930	COG0201	protein transport
C2U50_RS13995	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C2U50_RS14010	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C2U50_RS14035	COG0051	transcription antitermination factor activity, RNA binding
C2U50_RS14095	COG2964	Protein conserved in bacteria
C2U50_RS14100	COG0545	Peptidyl-prolyl cis-trans isomerase
C2U50_RS14110	COG1047	Peptidyl-prolyl cis-trans
C2U50_RS14115	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C2U50_RS14135	COG0488	(ABC) transporter
C2U50_RS14145	COG0429	hydrolase of the alpha beta-hydrolase fold
C2U50_RS14155	COG3954	Phosphoribulokinase
C2U50_RS14160	COG1765	OsmC-like protein
C2U50_RS14175	COG1289	transmembrane transporter activity
C2U50_RS14180	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2U50_RS14205	COG0738	Major facilitator superfamily
C2U50_RS14210	COG0402	S-adenosylhomocysteine deaminase activity
C2U50_RS14215	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U50_RS14240	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2U50_RS14245	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C2U50_RS14250	COG3266	domain, Protein
C2U50_RS14270	COG4796	Type ii and iii secretion system protein
C2U50_RS14295	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C2U50_RS14300	COG0494	nUDIX hydrolase
C2U50_RS14310	COG1011	Hydrolase
C2U50_RS14315	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C2U50_RS14340	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2U50_RS14345	COG2183	response to ionizing radiation
C2U50_RS14350	COG1918	ferrous iron import across plasma membrane
C2U50_RS14375	COG1040	competence protein
C2U50_RS14385	COG2610	gluconate transmembrane transporter activity
C2U50_RS14390	COG1640	4-alpha-glucanotransferase
C2U50_RS14395	COG0058	SHG alpha-glucan phosphorylase activity
C2U50_RS14400	COG3039	Transposase
C2U50_RS14415	COG1349	DNA-binding transcription factor activity
C2U50_RS14430	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C2U50_RS14435	COG0058	SHG alpha-glucan phosphorylase activity
C2U50_RS14460	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2U50_RS14470	COG2610	gluconate transmembrane transporter activity
C2U50_RS14475	COG3265	gluconokinase activity
C2U50_RS14480	COG1609	Transcriptional regulator
C2U50_RS14485	COG1741	Belongs to the pirin family
C2U50_RS14490	COG0673	inositol 2-dehydrogenase activity
C2U50_RS14500	COG1247	-acetyltransferase
C2U50_RS14505	COG0405	Gamma-glutamyltransferase
C2U50_RS14515	COG0584	glycerophosphoryl diester phosphodiesterase
C2U50_RS14565	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2U50_RS14570	COG0683	leucine binding
C2U50_RS14585	COG0683	leucine binding
C2U50_RS14600	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2U50_RS14615	COG2177	Part of the ABC transporter FtsEX involved in
C2U50_RS14620	COG2884	Cell division ATP-binding protein ftsE
C2U50_RS14625	COG0552	protein localization to endoplasmic reticulum
C2U50_RS14630	COG0742	ribosomal rna small subunit methyltransferase
C2U50_RS14635	COG3776	membrane
C2U50_RS14645	COG3714	YhhN family
C2U50_RS14660	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C2U50_RS14670	COG0477	Major facilitator Superfamily
C2U50_RS14675	COG0628	permease
C2U50_RS14715	COG3479	Phenolic acid decarboxylase
C2U50_RS14730	COG0747	negative chemotaxis
C2U50_RS14735	COG0601	transmembrane transport
C2U50_RS14740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U50_RS14750	COG1124	(ABC) transporter
C2U50_RS14760	COG2239	Acts as a magnesium transporter
C2U50_RS14765	COG2081	HI0933 family
C2U50_RS14770	COG0306	phosphate transporter
C2U50_RS14780	COG0589	response to stress
C2U50_RS14800	COG0671	phosphoesterase, PA-phosphatase related
C2U50_RS14805	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C2U50_RS14810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2U50_RS14820	COG1454	alcohol dehydrogenase
C2U50_RS14830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2U50_RS14835	COG1028	Short-chain dehydrogenase reductase Sdr
C2U50_RS14840	COG0583	DNA-binding transcription factor activity
C2U50_RS14845	COG1295	ribonuclease BN
C2U50_RS14850	COG0477	Major facilitator Superfamily
C2U50_RS14855	COG2982	Protein involved in outer membrane biogenesis
C2U50_RS14870	COG0612	Peptidase, M16
C2U50_RS14885	COG2199	diguanylate cyclase activity
C2U50_RS14885	COG2200	EAL domain
C2U50_RS14890	COG3118	belongs to the thioredoxin family
C2U50_RS14890	COG0457	Tetratricopeptide repeat
C2U50_RS14895	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C2U50_RS14900	COG1215	transferase activity, transferring glycosyl groups
C2U50_RS14930	COG2194	sulfuric ester hydrolase activity
C2U50_RS14950	COG1215	transferase activity, transferring glycosyl groups
C2U50_RS14960	COG2894	cell division
C2U50_RS14975	COG4608	Belongs to the ABC transporter superfamily
C2U50_RS14980	COG0444	Belongs to the ABC transporter superfamily
C2U50_RS14985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U50_RS14990	COG0601	transmembrane transport
C2U50_RS14995	COG0747	negative chemotaxis
C2U50_RS15035	COG2223	nitrite transmembrane transporter activity
C2U50_RS15040	COG5571	outer membrane autotransporter
C2U50_RS15045	COG2818	Glycosylase
C2U50_RS15050	COG0456	acetyltransferase
C2U50_RS15055	COG0243	molybdopterin cofactor binding
C2U50_RS15060	COG2885	chlorophyll binding
C2U50_RS15065	COG1609	Transcriptional regulator
C2U50_RS15075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U50_RS15100	COG2814	Major facilitator Superfamily
C2U50_RS15105	COG2944	sequence-specific DNA binding
C2U50_RS15110	COG1278	Cold shock
C2U50_RS15145	COG3274	enterobacterial common antigen metabolic process
C2U50_RS15150	COG4682	membrane
C2U50_RS15155	COG4682	membrane
C2U50_RS15175	COG4213	ABC transporter substrate-binding protein
C2U50_RS15190	COG1609	Transcriptional regulator
C2U50_RS15190	COG2207	Transcriptional regulator
C2U50_RS15195	COG2992	FlgJ-related protein
C2U50_RS15205	COG0366	Alpha amylase catalytic
C2U50_RS15210	COG3977	Valine--pyruvate aminotransferase
C2U50_RS15215	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2U50_RS15220	COG1414	Transcriptional regulator
C2U50_RS15225	COG3276	selenocysteine insertion sequence binding
C2U50_RS15235	COG0625	glutathione transferase activity
C2U50_RS15240	COG1566	PFAM secretion protein HlyD family protein
C2U50_RS15260	COG3722	fumarate hydratase activity
C2U50_RS15280	COG2186	Transcriptional regulator
C2U50_RS15290	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C2U50_RS15310	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C2U50_RS15315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2U50_RS15325	COG4942	peptidase
C2U50_RS15330	COG2861	carbohydrate metabolic process
C2U50_RS15335	COG0463	Glycosyl transferase, family 2
C2U50_RS15345	COG0156	8-amino-7-oxononanoate synthase activity
C2U50_RS15360	COG0859	PFAM glycosyl transferase family 9
C2U50_RS15385	COG0859	PFAM glycosyl transferase family 9
C2U50_RS15395	COG0438	transferase activity, transferring glycosyl groups
C2U50_RS15400	COG1216	Glycosyl transferase, family 2
C2U50_RS15405	COG1519	Transferase
C2U50_RS15440	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2U50_RS15470	COG0842	Transport permease protein
C2U50_RS15475	COG1131	(ABC) transporter
C2U50_RS15495	COG1561	YicC-like family, N-terminal region
C2U50_RS15500	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C2U50_RS15505	COG2169	Transcriptional regulator
C2U50_RS15505	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2U50_RS15515	COG2860	membrane
C2U50_RS15535	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2U50_RS15540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2U50_RS15545	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C2U50_RS15550	COG1494	fructose-1,6-bisphosphatase
C2U50_RS15560	COG3152	Membrane
C2U50_RS15585	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C2U50_RS15605	COG0786	glutamate:sodium symporter activity
C2U50_RS15610	COG2233	PERMEase
C2U50_RS15615	COG2982	Protein involved in outer membrane biogenesis
C2U50_RS15625	COG3039	Transposase
C2U50_RS15630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U50_RS15630	COG1263	PTS System
C2U50_RS15635	COG1486	melibiose metabolic process
C2U50_RS15645	COG1501	Belongs to the glycosyl hydrolase 31 family
C2U50_RS15650	COG2211	Major facilitator Superfamily
C2U50_RS15685	COG1064	alcohol dehydrogenase
C2U50_RS15695	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C2U50_RS15710	COG1464	Belongs to the NlpA lipoprotein family
C2U50_RS15735	COG0583	DNA-binding transcription factor activity
C2U50_RS15765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U50_RS15775	COG2814	Major facilitator Superfamily
C2U50_RS15785	COG1263	PTS System
C2U50_RS15785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U50_RS15790	COG0697	spore germination
C2U50_RS15805	COG2828	Protein conserved in bacteria
C2U50_RS15810	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2U50_RS15815	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C2U50_RS15820	COG0583	DNA-binding transcription factor activity
C2U50_RS15825	COG3384	dioxygenase
C2U50_RS15835	COG1609	Transcriptional regulator
C2U50_RS15845	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2U50_RS15845	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2U50_RS15850	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2U50_RS15855	COG4580	involved in the transport of maltose and maltodextrins
C2U50_RS15880	COG2188	Transcriptional regulator
C2U50_RS15925	COG2271	Major facilitator Superfamily
C2U50_RS15935	COG2197	response regulator
C2U50_RS15940	COG0440	acetolactate synthase activity
C2U50_RS15945	COG0028	Belongs to the TPP enzyme family
C2U50_RS15970	COG2814	Major facilitator Superfamily
C2U50_RS15975	COG0583	DNA-binding transcription factor activity
C2U50_RS15980	COG2610	gluconate transmembrane transporter activity
C2U50_RS16000	COG2149	membrane
C2U50_RS16015	COG2188	Transcriptional regulator
C2U50_RS16040	COG5645	(Lipo)protein
C2U50_RS16045	COG0823	Involved in the tonB-independent uptake of proteins
C2U50_RS16050	COG2271	Major facilitator Superfamily
C2U50_RS16060	COG0800	Aldolase
C2U50_RS16065	COG3734	2-keto-3-deoxy-galactonokinase
C2U50_RS16070	COG2186	Transcriptional regulator
C2U50_RS16085	COG0561	phosphatase activity
C2U50_RS16090	COG0187	DNA topoisomerase II activity
C2U50_RS16125	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C2U50_RS16160	COG2091	lysine biosynthetic process via aminoadipic acid
C2U50_RS16165	COG0431	NADPH-dependent FMN reductase
C2U50_RS16170	COG2252	PERMEase
C2U50_RS16180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U50_RS16185	COG0363	glucosamine-6-phosphate deaminase activity
C2U50_RS16190	COG2382	esterase
C2U50_RS16205	COG0704	Plays a role in the regulation of phosphate uptake
C2U50_RS16210	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2U50_RS16215	COG0581	inorganic phosphate transmembrane transporter activity
C2U50_RS16220	COG0573	inorganic phosphate transmembrane transporter activity
C2U50_RS16225	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C2U50_RS16230	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2U50_RS16280	COG3312	ion transport
C2U50_RS16295	COG0716	FMN binding
C2U50_RS16300	COG1522	sequence-specific DNA binding
C2U50_RS16330	COG1129	ABC transporter
C2U50_RS16335	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U50_RS16345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U50_RS16350	COG1609	Transcriptional regulator
C2U50_RS16355	COG0477	Major facilitator Superfamily
C2U50_RS16360	COG2186	Transcriptional regulator
C2U50_RS16390	COG1763	Mo-molybdopterin cofactor biosynthetic process
C2U50_RS16400	COG3084	Protein conserved in bacteria
C2U50_RS16405	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2U50_RS16415	COG0204	Acyl-transferase
C2U50_RS16450	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2U50_RS16460	COG3852	Histidine kinase
C2U50_RS16480	COG1011	Hydrolase
C2U50_RS16495	COG0456	acetyltransferase
C2U50_RS16500	COG0657	acetylesterase activity
C2U50_RS16505	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2U50_RS16520	COG2864	formate dehydrogenase
C2U50_RS16525	COG0437	4 iron, 4 sulfur cluster binding
C2U50_RS16550	COG0205	6-phosphofructokinase activity
C2U50_RS16610	COG2211	Major facilitator Superfamily
C2U50_RS16620	COG1454	alcohol dehydrogenase
C2U50_RS16625	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U50_RS16630	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U50_RS16635	COG1129	ABC transporter
C2U50_RS16680	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2U50_RS16685	COG2258	MOSC domain
C2U50_RS16690	COG2205	protein histidine kinase activity
C2U50_RS16695	COG0745	RESPONSE REGULATOR receiver
C2U50_RS16700	COG3678	ATP-independent chaperone mediated protein folding
C2U50_RS16720	COG1575	Belongs to the MenA family. Type 1 subfamily
C2U50_RS16735	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C2U50_RS16740	COG1609	Transcriptional regulator
C2U50_RS16745	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2U50_RS16760	COG0626	cystathionine gamma-synthase activity
C2U50_RS16765	COG0460	homoserine dehydrogenase
C2U50_RS16765	COG0527	aspartate kinase activity
C2U50_RS16775	COG0737	Belongs to the 5'-nucleotidase family
C2U50_RS16785	COG0583	DNA-binding transcription factor activity
C2U50_RS16795	COG0697	spore germination
C2U50_RS16800	COG0371	Dehydrogenase
C2U50_RS16810	COG2207	Transcriptional regulator
C2U50_RS16815	COG3443	Belongs to the bacterial solute-binding protein 9 family
C2U50_RS16830	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C2U50_RS16855	COG0583	DNA-binding transcription factor activity
C2U50_RS16930	COG3085	chromosome segregation
C2U50_RS16950	COG3978	acetolactate synthase activity
C2U50_RS16965	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2U50_RS16970	COG0583	DNA-binding transcription factor activity
C2U50_RS16980	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2U50_RS16985	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2U50_RS16995	COG1811	Na channel or pump
C2U50_RS17025	COG3118	belongs to the thioredoxin family
C2U50_RS17035	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C2U50_RS17040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2U50_RS17050	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C2U50_RS17055	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C2U50_RS17060	COG1088	dTDP-glucose 4,6-dehydratase activity
C2U50_RS17065	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C2U50_RS17070	COG0456	acetyltransferase
C2U50_RS17075	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2U50_RS17080	COG2244	polysaccharide biosynthetic process
C2U50_RS17125	COG3071	HemY protein
C2U50_RS17130	COG2959	enzyme of heme biosynthesis
C2U50_RS17145	COG3072	Adenylate cyclase
C2U50_RS17175	COG1011	Hydrolase
C2U50_RS17180	COG0210	DNA helicase
C2U50_RS17215	COG1280	lysine exporter protein (LysE YggA)
C2U50_RS17225	COG1280	lysine exporter protein (LysE YggA)
C2U50_RS17230	COG2267	carboxylic ester hydrolase activity
C2U50_RS17235	COG0561	phosphatase activity
C2U50_RS17240	COG0697	spore germination
C2U50_RS17245	COG0583	DNA-binding transcription factor activity
C2U50_RS17275	COG3165	ubiquinone biosynthetic process from chorismate
C2U50_RS17295	COG0805	protein transport
C2U50_RS17340	COG1739	Uncharacterized protein family UPF0029
C2U50_RS17350	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
C2U50_RS17435	COG0250	Participates in transcription elongation, termination and antitermination
C2U50_RS17475	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C2U50_RS17480	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2U50_RS17490	COG3706	GGDEF domain
C2U50_RS17510	COG2104	thiamine diphosphate biosynthetic process
C2U50_RS17515	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2U50_RS17530	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
C2U50_RS17565	COG3678	ATP-independent chaperone mediated protein folding
C2U50_RS17570	COG4191	Histidine kinase
C2U50_RS17580	COG0151	Belongs to the GarS family
C2U50_RS17620	COG0456	acetyltransferase
C2U50_RS17630	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C2U50_RS17660	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2U50_RS17715	COG0527	aspartate kinase activity
C2U50_RS17735	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C2U50_RS17745	COG0251	oxidation-reduction process
C2U50_RS17825	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C2U50_RS17835	COG0534	Mate efflux family protein
C2U50_RS17840	COG3237	CsbD-like
C2U50_RS17845	COG0735	belongs to the Fur family
C2U50_RS17855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2U50_RS17870	COG0305	Participates in initiation and elongation during chromosome replication
C2U50_RS17875	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2U50_RS17890	COG0432	Pfam Uncharacterised protein family UPF0047
C2U50_RS17895	COG2315	Protein conserved in bacteria
C2U50_RS17915	COG0741	lytic transglycosylase activity
C2U50_RS17920	COG4771	TonB-dependent receptor
C2U50_RS17940	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U50_RS17955	COG0483	inositol monophosphate 1-phosphatase activity
C2U50_RS17960	COG1609	Transcriptional regulator
C2U50_RS17965	COG1234	tRNA 3'-trailer cleavage
C2U50_RS18000	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C2U50_RS18010	COG0789	Transcriptional regulator
C2U50_RS18015	COG0625	glutathione transferase activity
C2U50_RS18020	COG2252	PERMEase
C2U50_RS18025	COG0025	NhaP-type Na H and K H
C2U50_RS18030	COG0583	DNA-binding transcription factor activity
C2U50_RS18035	COG1380	Effector of murein hydrolase LrgA
C2U50_RS18040	COG1346	cytolysis
C2U50_RS18045	COG3539	Fimbrial protein
C2U50_RS18075	COG3162	membrane
C2U50_RS18085	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2U50_RS18095	COG1301	dicarboxylic acid transport
C2U50_RS18100	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C2U50_RS18135	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U50_RS18140	COG1129	ABC transporter
C2U50_RS18145	COG4191	Histidine kinase
C2U50_RS18145	COG0784	Response regulator, receiver
C2U50_RS18155	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C2U50_RS18165	COG3454	Phosphonate metabolism
C2U50_RS18170	COG4778	phosphonate C-P lyase system protein PhnL
C2U50_RS18175	COG4107	phosphonate C-P lyase system protein PhnK
C2U50_RS18180	COG3627	carbon phosphorus lyase activity
C2U50_RS18185	COG3626	phosphonate metabolism
C2U50_RS18190	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
C2U50_RS18195	COG3624	Phosphonate C-P lyase system protein PhnG
C2U50_RS18200	COG2188	Transcriptional regulator
C2U50_RS18205	COG2764	glyoxalase bleomycin resistance protein dioxygenase
C2U50_RS18210	COG2824	Alkylphosphonate utilization operon protein PhnA
C2U50_RS18225	COG2169	Transcriptional regulator
C2U50_RS18235	COG1486	melibiose metabolic process
C2U50_RS18265	COG0861	Integral membrane protein TerC family
C2U50_RS18285	COG1215	transferase activity, transferring glycosyl groups
C2U50_RS18290	COG1649	PFAM Uncharacterised BCR, COG1649
C2U50_RS18290	COG0726	polysaccharide deacetylase
C2U50_RS18295	COG0457	Tetratricopeptide repeat
C2U50_RS18350	COG1309	transcriptional regulator
C2U50_RS18365	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C2U50_RS18370	COG1027	Aspartate ammonia-lyase
C2U50_RS18380	COG3030	protein affecting phage T7 exclusion by the F plasmid
C2U50_RS18385	COG0531	amino acid
C2U50_RS18425	COG3039	Transposase
C2U50_RS18450	COG1509	lysine 2,3-aminomutase activity
C2U50_RS18465	COG5510	response to toxic substance
C2U50_RS18470	COG2076	Multidrug Resistance protein
C2U50_RS18490	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2U50_RS18495	COG1053	succinate dehydrogenase
C2U50_RS18510	COG3264	Mechanosensitive ion channel
C2U50_RS18510	COG1511	domain protein
C2U50_RS18535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U50_RS18560	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C2U50_RS18565	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C2U50_RS18565	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C2U50_RS18570	COG0802	atpase or kinase
C2U50_RS18575	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2U50_RS18595	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C2U50_RS18600	COG0330	HflC and HflK could
C2U50_RS18605	COG0330	HflC and HflK could
C2U50_RS18615	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
C2U50_RS18630	COG0557	exoribonuclease II activity
C2U50_RS18635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2U50_RS18640	COG3789	protein conserved in bacteria
C2U50_RS18645	COG1842	Phage shock protein A
C2U50_RS18655	COG3766	membrane
C2U50_RS18660	COG5463	Belongs to the UPF0441 family
C2U50_RS18665	COG0754	glutathionylspermidine amidase activity
C2U50_RS18670	COG1960	acyl-CoA dehydrogenase activity
C2U50_RS18680	COG3650	response to hydrogen peroxide
C2U50_RS18685	COG1073	alpha beta
C2U50_RS18745	COG2965	DNA replication, synthesis of RNA primer
C2U50_RS18750	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C2U50_RS18760	COG3061	Opacity-associated protein A
C2U50_RS18765	COG0545	Peptidyl-prolyl cis-trans isomerase
C2U50_RS18770	COG1113	amino acid transport
C2U50_RS18780	COG0697	spore germination
C2U50_RS18790	COG0702	epimerase
C2U50_RS18795	COG1733	regulation of RNA biosynthetic process
C2U50_RS18810	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
C2U50_RS18835	COG1253	flavin adenine dinucleotide binding
C2U50_RS18845	COG0729	surface antigen
C2U50_RS18850	COG2911	Protein conserved in bacteria
C2U50_RS18855	COG2105	PFAM AIG2 family protein
C2U50_RS18870	COG1879	ABC-type sugar transport system periplasmic component
C2U50_RS18875	COG1129	ABC transporter
C2U50_RS18880	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U50_RS18885	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U50_RS18895	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2U50_RS18920	COG0312	modulator of DNA gyrase
C2U50_RS18955	COG3964	amidohydrolase
C2U50_RS18970	COG2706	6-phosphogluconolactonase activity
C2U50_RS18975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U50_RS18975	COG3711	transcriptional antiterminator
C2U50_RS18980	COG3077	Addiction module antitoxin, RelB DinJ family
C2U50_RS18985	COG2026	Addiction module toxin, RelE StbE family
C2U50_RS18990	COG0602	queuosine metabolic process
C2U50_RS19010	COG1486	melibiose metabolic process
C2U50_RS19015	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2U50_RS19020	COG0366	Alpha amylase catalytic
C2U50_RS19025	COG1263	PTS System
C2U50_RS19025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U50_RS19065	COG2731	YhcH YjgK YiaL family protein
C2U50_RS19070	COG2222	sugar isomerase
C2U50_RS19075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U50_RS19080	COG1228	amidohydrolase
C2U50_RS19085	COG1288	antiporter activity
C2U50_RS19090	COG2188	Transcriptional regulator
C2U50_RS19115	COG0525	valine-tRNA ligase activity
C2U50_RS19120	COG2927	DNA polymerase III (CHI subunit)
C2U50_RS19135	COG0795	lipopolysaccharide-transporting ATPase activity
C2U50_RS19140	COG0795	lipopolysaccharide-transporting ATPase activity
C2U50_RS19145	COG0433	COG0433 Predicted ATPase
C2U50_RS19160	COG3718	enzyme involved in inositol metabolism
C2U50_RS19170	COG1737	Transcriptional regulator
C2U50_RS19170	COG0837	glucose binding
C2U50_RS19175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U50_RS19180	COG3962	Belongs to the TPP enzyme family
C2U50_RS19190	COG1082	Xylose isomerase domain protein TIM barrel
C2U50_RS19210	COG3842	ATPase activity
C2U50_RS19215	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C2U50_RS19220	COG0395	ABC-type sugar transport system, permease component
C2U50_RS19225	COG1175	transmembrane transport
C2U50_RS19230	COG1064	alcohol dehydrogenase
C2U50_RS19235	COG0659	secondary active sulfate transmembrane transporter activity
C2U50_RS19240	COG0288	reversible hydration of carbon dioxide
C2U50_RS19255	COG0582	viral genome integration into host DNA
C2U50_RS19275	COG4974	Belongs to the 'phage' integrase family
C2U50_RS19420	COG1216	Glycosyl transferase, family 2
C2U50_RS19440	COG3507	Belongs to the glycosyl hydrolase 43 family
C2U50_RS19445	COG2211	Major facilitator Superfamily
C2U50_RS19455	COG4580	involved in the transport of maltose and maltodextrins
C2U50_RS19460	COG3272	Protein of unknown function (DUF1722)
C2U50_RS19480	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2U50_RS19495	COG0300	oxidoreductase activity
C2U50_RS19500	COG3631	Ketosteroid isomerase-related protein
C2U50_RS19505	COG0789	Transcriptional regulator
C2U50_RS19510	COG3040	lipid binding
C2U50_RS19520	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U50_RS19525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U50_RS19530	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U50_RS19535	COG1538	Outer membrane efflux protein
C2U50_RS19545	COG0745	RESPONSE REGULATOR receiver
C2U50_RS19550	COG5002	protein histidine kinase activity
C2U50_RS19565	COG2850	peptidyl-arginine hydroxylation
C2U50_RS19600	COG0842	Transport permease protein
C2U50_RS19605	COG0842	Transport permease protein
C2U50_RS19605	COG1129	ABC transporter
C2U50_RS19610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U50_RS19635	COG4869	propanediol catabolic process
C2U50_RS19645	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2U50_RS19650	COG1882	Formate acetyltransferase
C2U50_RS19665	COG1012	belongs to the aldehyde dehydrogenase family
C2U50_RS19665	COG1454	alcohol dehydrogenase
C2U50_RS19700	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2U50_RS19705	COG0583	DNA-binding transcription factor activity
C2U50_RS19715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U50_RS19720	COG5457	Domain of unknown function (DUF1127)
C2U50_RS19730	COG1566	PFAM secretion protein HlyD family protein
C2U50_RS19745	COG1924	4 iron, 4 sulfur cluster binding
C2U50_RS19750	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
C2U50_RS19765	COG2733	membrane
C2U50_RS19775	COG2207	Transcriptional regulator
C2U50_RS19775	COG1917	Cupin 2, conserved barrel domain protein
C2U50_RS19785	COG5464	transposase or invertase
C2U50_RS19790	COG1012	belongs to the aldehyde dehydrogenase family
C2U50_RS19800	COG0523	cobalamin synthesis protein
C2U50_RS19805	COG2879	small protein
C2U50_RS19810	COG1966	Carbon starvation protein
C2U50_RS19825	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2U50_RS19830	COG2368	4-hydroxyphenylacetate
C2U50_RS19850	COG3971	2-oxopent-4-enoate hydratase activity
C2U50_RS19860	COG3384	dioxygenase
C2U50_RS19865	COG1012	belongs to the aldehyde dehydrogenase family
C2U50_RS19875	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2U50_RS19880	COG1846	Transcriptional regulator
C2U50_RS19910	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C2U50_RS19935	COG3734	2-keto-3-deoxy-galactonokinase
C2U50_RS19940	COG0800	Aldolase
C2U50_RS19945	COG1737	Transcriptional regulator
C2U50_RS19955	COG1214	PFAM Peptidase M22, glycoprotease
C2U50_RS19955	COG0456	acetyltransferase
C2U50_RS19960	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C2U50_RS19960	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2U50_RS19975	COG3715	PTS system
C2U50_RS19980	COG3716	PTS system mannose fructose sorbose family IID component
C2U50_RS19985	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2U50_RS19995	COG5464	transposase or invertase
C2U50_RS20010	COG1484	DNA-dependent DNA replication
C2U50_RS20025	COG2966	Psort location CytoplasmicMembrane, score
C2U50_RS20045	COG2197	response regulator
C2U50_RS20050	COG2197	response regulator
C2U50_RS20060	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2U50_RS20060	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2U50_RS20065	COG4114	ferric iron reductase
C2U50_RS20070	COG3706	GGDEF domain
C2U50_RS20100	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
C2U50_RS20105	COG0456	acetyltransferase
C2U50_RS20110	COG1011	Hydrolase
C2U50_RS20120	COG2823	Periplasmic or secreted lipoprotein
C2U50_RS20130	COG4667	esterase of the alpha-beta hydrolase superfamily
C2U50_RS20135	COG0084	hydrolase, TatD family'
C2U50_RS20140	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2U50_RS20170	COG3726	membrane protein affecting hemolysin expression
C2U50_RS20180	COG0560	Phosphoserine phosphatase
C2U50_RS20185	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C2U50_RS20195	COG0488	(ABC) transporter
C2U50_RS20205	COG0741	lytic transglycosylase activity
C2U50_RS20225	COG2207	Transcriptional regulator
C2U50_RS20225	COG3708	Transcriptional regulator
C2U50_RS20230	COG3045	CreA protein
C2U50_RS20235	COG0745	RESPONSE REGULATOR receiver
C2U50_RS20240	COG2205	protein histidine kinase activity
C2U50_RS20245	COG4452	Inner membrane protein CreD
C2U50_RS20250	COG0745	RESPONSE REGULATOR receiver
C2U50_RS20265	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C2U50_RS20275	COG0527	aspartate kinase activity
C2U50_RS20275	COG0460	homoserine dehydrogenase
C2U50_RS20285	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C2U50_RS20300	COG1115	amino acid carrier protein
C2U50_RS20305	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2U50_RS20310	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2U50_RS20315	COG0477	Major facilitator Superfamily
C2U50_RS20320	COG1584	GPR1 FUN34 yaaH family protein
C2U50_RS20325	COG4735	regulation of single-species biofilm formation
C2U50_RS20350	COG0583	DNA-binding transcription factor activity
C2U50_RS20370	COG0196	riboflavin kinase activity
C2U50_RS20385	COG1047	Peptidyl-prolyl cis-trans
C2U50_RS20410	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C2U50_RS20425	COG0505	Belongs to the CarA family
C2U50_RS20480	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C2U50_RS20490	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C2U50_RS20495	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C2U50_RS20510	COG3493	citrate carrier protein
C2U50_RS20525	COG0564	pseudouridine synthase activity
C2U50_RS20535	COG0417	DNA replication proofreading
C2U50_RS20540	COG0235	Class ii aldolase
C2U50_RS20560	COG0586	Pfam SNARE associated Golgi protein
C2U50_RS20570	COG1178	ABC-type Fe3 transport system permease component
C2U50_RS20590	COG2814	Major facilitator Superfamily
C2U50_RS20595	COG2271	Major facilitator Superfamily
C2U50_RS20600	COG0583	DNA-binding transcription factor activity
C2U50_RS20610	COG0738	Major facilitator superfamily
C2U50_RS20660	COG0028	Belongs to the TPP enzyme family
C2U50_RS20670	COG1609	Transcriptional regulator
C2U50_RS20695	COG0768	penicillin binding
C2U50_RS20700	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2U50_RS20705	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2U50_RS20720	COG0772	Belongs to the SEDS family
C2U50_RS20745	COG0849	cell division
C2U50_RS20750	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C2U50_RS20770	COG0494	nUDIX hydrolase
C2U50_RS20795	COG1459	type II secretion system
C2U50_RS20800	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2U50_RS20805	COG4969	Belongs to the N-Me-Phe pilin family
C2U50_RS20815	COG3023	N-Acetylmuramoyl-L-alanine amidase
C2U50_RS20820	COG3725	Membrane protein required for beta-lactamase induction
C2U50_RS20825	COG3940	Belongs to the glycosyl hydrolase 43 family
C2U50_RS20830	COG2211	Major facilitator Superfamily
C2U50_RS20835	COG1113	amino acid transport
C2U50_RS20840	COG2186	Transcriptional regulator
C2U50_RS20845	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C2U50_RS20850	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2U50_RS20855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2U50_RS20870	COG3064	Membrane
C2U50_RS20920	COG2132	Multicopper oxidase
C2U50_RS20925	COG4993	Dehydrogenase
C2U50_RS20935	COG0288	reversible hydration of carbon dioxide
C2U50_RS20940	COG1131	(ABC) transporter
C2U50_RS20945	COG0842	Transport permease protein
C2U50_RS20950	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U50_RS20955	COG0726	polysaccharide deacetylase
C2U50_RS20975	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C2U50_RS20980	COG0617	tRNA 3'-terminal CCA addition
C2U50_RS21000	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C2U50_RS21005	COG1643	Atp-dependent helicase
C2U50_RS21095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2U50_RS21105	COG1120	ATPase activity
C2U50_RS21110	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2U50_RS21115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U50_RS21135	COG2860	membrane
C2U50_RS21155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U50_RS21160	COG3835	regulator
C2U50_RS21175	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C2U50_RS21180	COG0024	Methionine aminopeptidase
C2U50_RS21205	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C2U50_RS21220	COG0575	Belongs to the CDS family
C2U50_RS21225	COG0750	zinc metalloprotease
C2U50_RS21235	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
C2U50_RS21265	COG0587	DNA-directed DNA polymerase activity
C2U50_RS21275	COG1982	Orn Lys Arg decarboxylase major
C2U50_RS21280	COG0346	lactoylglutathione lyase activity
C2U50_RS21290	COG4568	rho-dependent transcription termination
C2U50_RS21305	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C2U50_RS21310	COG3015	lipoprotein NlpE involved in copper resistance
C2U50_RS21315	COG0791	NLP P60 protein
C2U50_RS21325	COG1720	tRNA m6t6A37 methyltransferase activity
C2U50_RS21335	COG1464	Belongs to the NlpA lipoprotein family
C2U50_RS21340	COG2011	ABC-type metal ion transport system permease component
C2U50_RS21350	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C2U50_RS21390	COG0656	L-ascorbic acid biosynthetic process
C2U50_RS21395	COG0583	DNA-binding transcription factor activity
C2U50_RS21400	COG2814	Major facilitator Superfamily
C2U50_RS21410	COG2226	methyltransferase
C2U50_RS21415	COG1388	LysM domain
C2U50_RS21415	COG0741	lytic transglycosylase activity
C2U50_RS21425	COG2226	methyltransferase
C2U50_RS21435	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2U50_RS21450	COG0583	DNA-binding transcription factor activity
C2U50_RS21460	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2U50_RS21465	COG1960	acyl-CoA dehydrogenase activity
C2U50_RS21475	COG0121	glutamine amidotransferase
C2U50_RS21480	COG3034	peptidoglycan biosynthetic process
C2U50_RS21500	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U50_RS21505	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U50_RS21520	COG2991	Protein conserved in bacteria
C2U50_RS21535	COG0454	-acetyltransferase
C2U50_RS21540	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2U50_RS21560	COG1802	Transcriptional regulator
C2U50_RS21565	COG1113	amino acid transport
C2U50_RS21570	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2U50_RS21575	COG1012	belongs to the aldehyde dehydrogenase family
C2U50_RS21580	COG0579	oxidoreductase
C2U50_RS21620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2U50_RS21625	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2U50_RS21630	COG0022	dehydrogenase e1 component
C2U50_RS21640	COG2909	trisaccharide binding
C2U50_RS21655	COG4581	dead DEAH box helicase
C2U50_RS21685	COG0791	NLP P60 protein
C2U50_RS21715	COG3639	organic phosphonate transmembrane transporter activity
C2U50_RS21725	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C2U50_RS21750	COG3188	usher protein
C2U50_RS21765	COG0765	amino acid transport
C2U50_RS21770	COG4597	amino acid ABC transporter
C2U50_RS21775	COG1126	abc transporter atp-binding protein
C2U50_RS21780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U50_RS21820	COG4302	ethanolamine ammonia-lyase activity
C2U50_RS21825	COG4303	Ethanolamine ammonia lyase large subunit
C2U50_RS21835	COG0833	amino acid
C2U50_RS21840	COG2040	homocysteine
C2U50_RS21845	COG4521	taurine ABC transporter
C2U50_RS21850	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C2U50_RS21855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U50_RS21860	COG2175	clavaminate synthase activity
C2U50_RS21870	COG1943	Transposase
C2U50_RS21875	COG0113	porphobilinogen synthase activity
C2U50_RS21880	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2U50_RS21885	COG1335	isochorismatase
C2U50_RS21890	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
C2U50_RS21930	COG1785	Belongs to the alkaline phosphatase family
C2U50_RS21940	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2U50_RS21950	COG3416	Protein conserved in bacteria
C2U50_RS21955	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C2U50_RS21965	COG4126	flavin adenine dinucleotide binding
C2U50_RS21980	COG1940	carbohydrate kinase activity
C2U50_RS21985	COG0419	ATPase involved in DNA repair
C2U50_RS21990	COG0420	3'-5' exonuclease activity
C2U50_RS22015	COG0366	Alpha amylase catalytic
C2U50_RS22020	COG0583	DNA-binding transcription factor activity
C2U50_RS22025	COG1335	isochorismatase
C2U50_RS22035	COG1228	amidohydrolase
C2U50_RS22045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U50_RS22060	COG3039	Transposase
C2U50_RS22065	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U50_RS22070	COG0450	alkyl hydroperoxide reductase
C2U50_RS22090	COG1862	Preprotein translocase
C2U50_RS22095	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U50_RS22100	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U50_RS22120	COG4238	major outer membrane lipoprotein
C2U50_RS22130	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2U50_RS22130	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2U50_RS22150	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C2U50_RS22155	COG0667	Aldo Keto reductase
C2U50_RS22165	COG0142	geranyltranstransferase activity
C2U50_RS22185	COG0693	protein deglycase activity
C2U50_RS22190	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2U50_RS22200	COG2814	Major facilitator Superfamily
C2U50_RS22205	COG0673	inositol 2-dehydrogenase activity
C2U50_RS22220	COG1053	succinate dehydrogenase
C2U50_RS22230	COG1053	succinate dehydrogenase
C2U50_RS22235	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2U50_RS22240	COG1414	Transcriptional regulator
C2U50_RS22255	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C2U50_RS22260	COG1845	cytochrome c oxidase, subunit III
C2U50_RS22265	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2U50_RS22270	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2U50_RS22275	COG2223	nitrite transmembrane transporter activity
C2U50_RS22280	COG3056	Lipoprotein
C2U50_RS22285	COG0271	Belongs to the BolA IbaG family
C2U50_RS22315	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C2U50_RS22320	COG0776	regulation of translation
C2U50_RS22325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2U50_RS22330	COG1555	photosystem II stabilization
C2U50_RS22335	COG0824	Thioesterase
C2U50_RS22345	COG4533	DNA binding
C2U50_RS22360	COG1522	sequence-specific DNA binding
C2U50_RS22365	COG1132	(ABC) transporter
C2U50_RS22370	COG1132	(ABC) transporter
C2U50_RS22375	COG0347	Belongs to the P(II) protein family
C2U50_RS22380	COG0004	ammonium transporteR
C2U50_RS22385	COG1946	Acyl-CoA thioesterase
C2U50_RS22390	COG3126	Type III secretion system lipoprotein chaperone (YscW)
C2U50_RS22395	COG3695	enzyme binding
C2U50_RS22410	COG0582	viral genome integration into host DNA
C2U50_RS22465	COG3039	Transposase
C2U50_RS22495	COG2364	Membrane
C2U50_RS22510	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C2U50_RS22520	COG2182	Extracellular solute-binding protein
C2U50_RS22525	COG1175	transmembrane transport
C2U50_RS22530	COG3833	ABC-type maltose transport systems, permease component
C2U50_RS22535	COG3867	Arabinogalactan endo-beta-1,4-galactanase
C2U50_RS22540	COG1874	Beta-galactosidase
C2U50_RS22585	COG0110	maltose O-acetyltransferase activity
C2U50_RS22600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U50_RS22605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U50_RS22610	COG1309	transcriptional regulator
C2U50_RS22615	COG1196	nuclear chromosome segregation
C2U50_RS22615	COG3264	Mechanosensitive ion channel
C2U50_RS22630	COG3923	Primosomal replication protein n
C2U50_RS22635	COG2832	Protein of unknown function (DUF454)
C2U50_RS22680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U50_RS22685	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2U50_RS22685	COG4651	solute:proton antiporter activity
C2U50_RS22690	COG2223	nitrite transmembrane transporter activity
C2U50_RS22700	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2U50_RS22705	COG3735	TraB family
C2U50_RS22720	COG1585	Membrane protein implicated in regulation of membrane protease activity
C2U50_RS22725	COG0330	HflC and HflK could
C2U50_RS22730	COG4619	ABC transporter
C2U50_RS22735	COG0390	transport system, permease component
C2U50_RS22745	COG3118	belongs to the thioredoxin family
C2U50_RS22750	COG0300	oxidoreductase activity
C2U50_RS22755	COG2755	lipolytic protein G-D-S-L family
C2U50_RS22760	COG4181	ATPase activity
C2U50_RS22765	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C2U50_RS22780	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C2U50_RS22785	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C2U50_RS22815	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2U50_RS22825	COG2501	S4 domain
C2U50_RS22845	COG0582	viral genome integration into host DNA
C2U50_RS22925	COG3756	Protein conserved in bacteria
C2U50_RS23015	COG3772	lysozyme
C2U50_RS23030	COG5410	chromosome segregation
C2U50_RS23115	COG1196	nuclear chromosome segregation
C2U50_RS23115	COG0739	heme binding
C2U50_RS23115	COG0741	lytic transglycosylase activity
C2U50_RS23220	COG3039	Transposase
C2U50_RS23250	COG1560	Kdo2-lipid A biosynthetic process
C2U50_RS23265	COG3039	Transposase
C2U50_RS23275	COG3710	Transcriptional regulator
C2U50_RS23280	COG0531	amino acid
C2U50_RS23285	COG1982	Orn Lys Arg decarboxylase major
C2U50_RS23290	COG3104	oligopeptide transport
C2U50_RS23325	COG0673	inositol 2-dehydrogenase activity
C2U50_RS23340	COG1129	ABC transporter
C2U50_RS23345	COG4211	Belongs to the binding-protein-dependent transport system permease family
C2U50_RS23390	COG1566	PFAM secretion protein HlyD family protein
C2U50_RS23395	COG1120	ATPase activity
C2U50_RS23400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U50_RS23420	COG1473	amidohydrolase
C2U50_RS23425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U50_RS23430	COG0667	Aldo Keto reductase
C2U50_RS23490	COG4680	protein conserved in bacteria
C2U50_RS23505	COG0531	amino acid
C2U50_RS23515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U50_RS23520	COG1012	belongs to the aldehyde dehydrogenase family
C2U50_RS23535	COG1113	amino acid transport
C2U50_RS23540	COG2211	Major facilitator Superfamily
C2U50_RS23560	COG1609	Transcriptional regulator
C2U50_RS23565	COG0668	transmembrane transport
C2U50_RS23570	COG0477	Major facilitator Superfamily
C2U50_RS23600	COG0778	Nitroreductase
C2U50_RS23605	COG2315	Protein conserved in bacteria
C2U50_RS23655	COG3698	Phosphodiester glycosidase
C2U50_RS23665	COG0697	spore germination
C2U50_RS23680	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C2U50_RS23685	COG0765	amino acid transport
C2U50_RS23690	COG4215	(ABC) transporter
C2U50_RS23700	COG4221	oxidoreductase activity
C2U50_RS23705	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2U50_RS23710	COG4608	Belongs to the ABC transporter superfamily
C2U50_RS23715	COG0444	Belongs to the ABC transporter superfamily
C2U50_RS23720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U50_RS23725	COG0601	transmembrane transport
C2U50_RS23730	COG0747	negative chemotaxis
C2U50_RS23760	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2U50_RS23770	COG0668	transmembrane transport
C2U50_RS23775	COG0583	DNA-binding transcription factor activity
C2U50_RS23785	COG1028	Short-chain dehydrogenase reductase Sdr
C2U50_RS23795	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U50_RS23800	COG1129	ABC transporter
C2U50_RS23810	COG1879	ABC-type sugar transport system periplasmic component
C2U50_RS23815	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C2U50_RS23820	COG2390	Transcriptional regulator
C2U50_RS23830	COG3959	Transketolase, thiamine diphosphate binding domain
C2U50_RS23835	COG3958	Transketolase
C2U50_RS23840	COG2977	Belongs to the P-Pant transferase superfamily
C2U50_RS23845	COG4771	TonB-dependent receptor
C2U50_RS23850	COG2382	esterase
C2U50_RS23855	COG3251	PFAM MbtH domain protein
C2U50_RS23860	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C2U50_RS23860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2U50_RS23865	COG1120	ATPase activity
C2U50_RS23870	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U50_RS23875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U50_RS23885	COG4592	Periplasmic binding protein
C2U50_RS23890	COG1169	isochorismate synthase
C2U50_RS23895	COG1021	2,3-dihydroxybenzoate-AMP ligase
C2U50_RS23900	COG3433	isochorismatase activity
C2U50_RS23900	COG1535	isochorismatase
C2U50_RS23905	COG1028	Short-chain dehydrogenase reductase Sdr
C2U50_RS23915	COG1966	Carbon starvation protein
C2U50_RS23920	COG2879	small protein
C2U50_RS23935	COG1028	Short-chain dehydrogenase reductase Sdr
C2U50_RS23940	COG0371	Dehydrogenase
C2U50_RS23945	COG1129	ABC transporter
C2U50_RS23950	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U50_RS23980	COG2271	Major facilitator Superfamily
C2U50_RS23985	COG0483	inositol monophosphate 1-phosphatase activity
C2U50_RS23995	COG0402	S-adenosylhomocysteine deaminase activity
C2U50_RS24005	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2U50_RS24020	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2U50_RS24030	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U50_RS24035	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U50_RS24040	COG1129	ABC transporter
C2U50_RS24065	COG0436	Aminotransferase
C2U50_RS24070	COG1475	DNA binding
C2U50_RS24075	COG3969	phosphoadenosine phosphosulfate
C2U50_RS24080	COG0583	DNA-binding transcription factor activity
C2U50_RS24085	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2U50_RS24105	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2U50_RS24110	COG3719	Belongs to the RNase T2 family
C2U50_RS24115	COG3069	C4-dicarboxylate transmembrane transporter activity
C2U50_RS24135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2U50_RS24150	COG0583	DNA-binding transcription factor activity
C2U50_RS24165	COG1686	Belongs to the peptidase S11 family
C2U50_RS24170	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C2U50_RS24175	COG0772	Belongs to the SEDS family
C2U50_RS24180	COG0768	penicillin binding
C2U50_RS24190	COG0799	negative regulation of ribosome biogenesis
C2U50_RS24210	COG1466	dna polymerase III delta subunit
C2U50_RS24225	COG2888	peptidyl-tyrosine sulfation
C2U50_RS24240	COG1126	abc transporter atp-binding protein
C2U50_RS24245	COG0765	amino acid transport
C2U50_RS24250	COG0765	amino acid transport
C2U50_RS24275	COG1702	phosphate starvation-inducible protein PhoH
C2U50_RS24285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U50_RS24330	COG0367	asparagine synthase
C2U50_RS24335	COG0647	UMP catabolic process
C2U50_RS24340	COG1846	Transcriptional regulator
C2U50_RS24340	COG1940	carbohydrate kinase activity
C2U50_RS24345	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2U50_RS24390	COG0735	belongs to the Fur family
C2U50_RS24405	COG0596	Alpha beta hydrolase
C2U50_RS24415	COG0033	Phosphoglucomutase
C2U50_RS24425	COG0745	RESPONSE REGULATOR receiver
C2U50_RS24430	COG2205	protein histidine kinase activity
C2U50_RS24460	COG0415	Belongs to the DNA photolyase family
C2U50_RS24475	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C2U50_RS24480	COG1984	allophanate hydrolase subunit 2
C2U50_RS24525	COG2009	succinate dehydrogenase
C2U50_RS24530	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C2U50_RS24535	COG1053	succinate dehydrogenase
C2U50_RS24540	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2U50_RS24545	COG0567	Dehydrogenase, E1 component
C2U50_RS24550	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2U50_RS24565	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2U50_RS24575	COG1271	oxidase subunit
C2U50_RS24580	COG1294	oxidase, subunit
C2U50_RS24585	COG4890	Cyd operon protein YbgT
C2U50_RS24590	COG3790	cyd operon protein YbgE
C2U50_RS24595	COG0824	Thioesterase
C2U50_RS24600	COG0811	peptide transport
C2U50_RS24605	COG0848	biopolymer transport protein
C2U50_RS24610	COG3064	Membrane
C2U50_RS24620	COG2885	chlorophyll binding
C2U50_RS24625	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C2U50_RS24675	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C2U50_RS24680	COG3201	nicotinamide mononucleotide transporter
C2U50_RS24695	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U50_RS24705	COG2017	converts alpha-aldose to the beta-anomer
C2U50_RS24715	COG1085	galactose-1-phosphate uridylyltransferase
C2U50_RS24725	COG1119	ATPase activity
C2U50_RS24730	COG3585	molybdate ion transport
C2U50_RS24730	COG2005	Transcriptional regulator
C2U50_RS24740	COG0725	ABC transporter, periplasmic molybdate-binding protein
C2U50_RS24745	COG4149	molybdate abc transporter
C2U50_RS24755	COG0561	phosphatase activity
C2U50_RS24780	COG2200	EAL domain
C2U50_RS24785	COG0789	Transcriptional regulator
C2U50_RS24815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U50_RS24820	COG0589	response to stress
C2U50_RS24835	COG4677	pectinesterase activity
C2U50_RS24870	COG1881	PFAM PEBP family protein
C2U50_RS24875	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2U50_RS24890	COG2226	methyltransferase
C2U50_RS24925	COG0642	Histidine kinase
C2U50_RS24930	COG0745	RESPONSE REGULATOR receiver
C2U50_RS24945	COG4644	lycopene metabolic process
C2U50_RS24965	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2U50_RS24975	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C2U50_RS24980	COG0314	molybdopterin synthase activity
C2U50_RS24985	COG0670	Belongs to the BI1 family
C2U50_RS24995	COG0392	lysyltransferase activity
C2U50_RS25000	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U50_RS25005	COG3568	Endonuclease Exonuclease Phosphatase
C2U50_RS25020	COG0842	Transport permease protein
C2U50_RS25025	COG0842	Transport permease protein
C2U50_RS25030	COG1131	(ABC) transporter
C2U50_RS25035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U50_RS25045	COG1309	transcriptional regulator
C2U50_RS25050	COG0583	DNA-binding transcription factor activity
C2U50_RS25060	COG1028	Short-chain dehydrogenase reductase Sdr
C2U50_RS25065	COG3959	Transketolase, thiamine diphosphate binding domain
C2U50_RS25070	COG3958	Transketolase
C2U50_RS25075	COG0513	Belongs to the DEAD box helicase family
C2U50_RS25080	COG1199	ATP-dependent helicase activity
C2U50_RS25085	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2U50_RS25095	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2U50_RS25105	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2U50_RS25115	COG0668	transmembrane transport
C2U50_RS25120	COG1126	abc transporter atp-binding protein
C2U50_RS25125	COG0765	amino acid transport
C2U50_RS25130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U50_RS25145	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C2U50_RS25150	COG2194	sulfuric ester hydrolase activity
C2U50_RS25165	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2U50_RS25170	COG2723	6-phospho-beta-galactosidase activity
C2U50_RS25175	COG2188	Transcriptional regulator
C2U50_RS25180	COG1376	ErfK ybiS ycfS ynhG family protein
C2U50_RS25185	COG2365	Tyrosine phosphatase family
C2U50_RS25200	COG3039	Transposase
C2U50_RS25240	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2U50_RS25245	COG0488	(ABC) transporter
C2U50_RS25260	COG2271	Major facilitator Superfamily
C2U50_RS25265	COG1609	Transcriptional regulator
C2U50_RS25275	COG0561	phosphatase activity
C2U50_RS25280	COG1882	Formate acetyltransferase
C2U50_RS25285	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2U50_RS25290	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2U50_RS25295	COG0303	'Molybdopterin
C2U50_RS25310	COG0747	negative chemotaxis
C2U50_RS25345	COG2133	pyrroloquinoline quinone binding
C2U50_RS25350	COG0625	glutathione transferase activity
C2U50_RS25355	COG1686	Belongs to the peptidase S11 family
C2U50_RS25360	COG1349	DNA-binding transcription factor activity
C2U50_RS25365	COG0671	phosphoesterase, PA-phosphatase related
C2U50_RS25375	COG2814	Major facilitator Superfamily
C2U50_RS25380	COG0561	phosphatase activity
C2U50_RS25385	COG0738	Major facilitator superfamily
C2U50_RS25390	COG3226	Transcriptional regulator
C2U50_RS25415	COG0778	Nitroreductase
C2U50_RS25430	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C2U50_RS25435	COG3842	ATPase activity
C2U50_RS25440	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2U50_RS25445	COG1177	transmembrane transport
C2U50_RS25460	COG0745	RESPONSE REGULATOR receiver
C2U50_RS25465	COG5002	protein histidine kinase activity
C2U50_RS25470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U50_RS25475	COG4160	amino acid transport
C2U50_RS25480	COG4215	(ABC) transporter
C2U50_RS25485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U50_RS25490	COG1126	abc transporter atp-binding protein
C2U50_RS25505	COG5001	Diguanylate cyclase
C2U50_RS25505	COG2203	Gaf domain
C2U50_RS25505	COG4251	negative regulation of phosphorylation
C2U50_RS25505	COG3706	GGDEF domain
C2U50_RS25510	COG3023	N-Acetylmuramoyl-L-alanine amidase
C2U50_RS25515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2U50_RS25520	COG0702	epimerase
C2U50_RS25525	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C2U50_RS25530	COG0028	Belongs to the TPP enzyme family
C2U50_RS25540	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U50_RS25550	COG2431	L-lysine efflux transmembrane transporter activity
C2U50_RS25560	COG3593	DNA synthesis involved in DNA repair
C2U50_RS25565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U50_RS25580	COG1278	Cold shock
C2U50_RS25590	COG0542	response to heat
C2U50_RS25605	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C2U50_RS25610	COG4988	ABC transporter
C2U50_RS25615	COG0492	ferredoxin-NADP+ reductase activity
C2U50_RS25625	COG1178	ABC-type Fe3 transport system permease component
C2U50_RS25625	COG1674	ftsk spoiiie
C2U50_RS25635	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C2U50_RS25645	COG0243	molybdopterin cofactor binding
C2U50_RS25650	COG0437	4 iron, 4 sulfur cluster binding
C2U50_RS25655	COG3302	dmso reductase anchor subunit
C2U50_RS25665	COG0477	Major facilitator Superfamily
C2U50_RS25670	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2U50_RS25675	COG1882	Formate acetyltransferase
C2U50_RS25680	COG2116	formate transmembrane transporter activity
C2U50_RS25685	COG1944	ATP diphosphatase activity
C2U50_RS25690	COG2323	membrane
C2U50_RS25710	COG0539	negative regulation of cytoplasmic translation
C2U50_RS25720	COG2333	competence protein COMEC
C2U50_RS25720	COG0658	competence protein
C2U50_RS25735	COG3214	Protein conserved in bacteria
C2U50_RS25750	COG3173	Aminoglycoside phosphotransferase
C2U50_RS25755	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C2U50_RS25760	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2U50_RS25770	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
C2U50_RS25780	COG2989	Protein conserved in bacteria
C2U50_RS25790	COG3108	Peptidase M15
C2U50_RS25795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2U50_RS25800	COG1448	Aminotransferase
C2U50_RS25805	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2U50_RS25815	COG1522	sequence-specific DNA binding
C2U50_RS25825	COG0814	amino acid
C2U50_RS25835	COG1473	amidohydrolase
C2U50_RS25850	COG0308	aminopeptidase N
C2U50_RS25860	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U50_RS25865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U50_RS25870	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2U50_RS25875	COG0431	NADPH-dependent FMN reductase
C2U50_RS25890	COG0633	Ferredoxin
C2U50_RS25890	COG3217	Mosc domain protein beta barrel domain protein
C2U50_RS25900	COG0488	(ABC) transporter
C2U50_RS25905	COG2995	paraquat-inducible protein a
C2U50_RS25910	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2U50_RS25910	COG3008	intermembrane lipid transfer
C2U50_RS25915	COG3009	Protein conserved in bacteria
C2U50_RS25925	COG3130	regulation of translation
C2U50_RS25935	COG1067	ATP-dependent peptidase activity
C2U50_RS25960	COG3070	regulator of competence-specific genes
C2U50_RS25965	COG1289	transmembrane transporter activity
C2U50_RS25970	COG3304	Inner membrane component domain
C2U50_RS25975	COG0210	DNA helicase
C2U50_RS25985	COG1832	CoA-binding protein
C2U50_RS26010	COG3039	Transposase
C2U50_RS26035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U50_RS26060	COG1881	PFAM PEBP family protein
C2U50_RS26065	COG2207	Transcriptional regulator
C2U50_RS26080	COG0670	Belongs to the BI1 family
C2U50_RS26130	COG1396	sequence-specific DNA binding
C2U50_RS26155	COG0305	Participates in initiation and elongation during chromosome replication
C2U50_RS26290	COG0741	lytic transglycosylase activity
C2U50_RS26325	COG3772	lysozyme
C2U50_RS26365	COG2200	EAL domain
C2U50_RS26370	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U50_RS26375	COG1012	belongs to the aldehyde dehydrogenase family
C2U50_RS26380	COG4638	Rieske (2fe-2S)
C2U50_RS26385	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2U50_RS26390	COG0473	3-isopropylmalate dehydrogenase activity
C2U50_RS26395	COG0583	DNA-binding transcription factor activity
C2U50_RS26400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U50_RS26405	COG1012	belongs to the aldehyde dehydrogenase family
C2U50_RS26410	COG1396	sequence-specific DNA binding
C2U50_RS26410	COG1917	Cupin 2, conserved barrel domain protein
C2U50_RS26415	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C2U50_RS26420	COG0174	glutamine synthetase
C2U50_RS26430	COG0531	amino acid
C2U50_RS26445	COG1028	Short-chain dehydrogenase reductase Sdr
C2U50_RS26470	COG3729	General stress protein
C2U50_RS26480	COG2233	PERMEase
C2U50_RS26515	COG1309	transcriptional regulator
C2U50_RS26535	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2U50_RS26545	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2U50_RS26565	COG1702	phosphate starvation-inducible protein PhoH
C2U50_RS26570	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2U50_RS26665	COG1335	isochorismatase
C2U50_RS26675	COG0583	DNA-binding transcription factor activity
C2U50_RS26705	COG3381	protein complex oligomerization
C2U50_RS26745	COG5645	(Lipo)protein
C2U50_RS26765	COG1560	Kdo2-lipid A biosynthetic process
C2U50_RS26805	COG3344	reverse transcriptase
C2U50_RS26830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2U50_RS26850	COG2814	Major facilitator Superfamily
C2U50_RS26855	COG0583	DNA-binding transcription factor activity
C2U50_RS26860	COG1530	ribonuclease E activity
C2U50_RS26880	COG1399	metal-binding, possibly nucleic acid-binding protein
C2U50_RS26900	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2U50_RS26915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2U50_RS26920	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2U50_RS26925	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2U50_RS26935	COG0470	DNA polymerase III
C2U50_RS26940	COG0084	hydrolase, TatD family'
C2U50_RS26950	COG0537	adenosine 5'-monophosphoramidase activity
C2U50_RS26955	COG5633	Lipoprotein
C2U50_RS26980	COG1252	NADH dehydrogenase
C2U50_RS26985	COG3134	Outer membrane lipoprotein
C2U50_RS26995	COG1309	transcriptional regulator
C2U50_RS27005	COG1376	ErfK ybiS ycfS ynhG family protein
C2U50_RS27005	COG1388	LysM domain
C2U50_RS27010	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C2U50_RS27020	COG4591	ABC-type transport system involved in lipoprotein release permease component
C2U50_RS27030	COG4591	ABC-type transport system involved in lipoprotein release permease component
C2U50_RS27040	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C2U50_RS27050	COG0318	PFAM AMP-dependent synthetase and ligase
C2U50_RS27065	COG1177	transmembrane transport
C2U50_RS27090	COG1943	Transposase
C2U50_RS27105	COG2850	peptidyl-arginine hydroxylation
C2U50_RS27110	COG2205	protein histidine kinase activity
C2U50_RS27130	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C2U50_RS27150	COG1187	pseudouridine synthase activity
C2U50_RS27155	COG0538	isocitrate dehydrogenase activity
C2U50_RS27160	COG0582	viral genome integration into host DNA
C2U50_RS27210	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
C2U50_RS27215	COG5532	Uncharacterized conserved protein (DUF2303)
C2U50_RS27260	COG4626	Terminase
C2U50_RS27260	COG1802	Transcriptional regulator
C2U50_RS27280	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2U50_RS27295	COG1403	HNH endonuclease
C2U50_RS27300	COG0484	heat shock protein binding
C2U50_RS27325	COG3179	chitinase
C2U50_RS27365	COG1802	Transcriptional regulator
C2U50_RS27365	COG4626	Terminase
C2U50_RS27370	COG4695	Portal protein
C2U50_RS27480	COG3344	reverse transcriptase
C2U50_RS27485	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2U50_RS27490	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2U50_RS27500	COG2135	peptidase activity
C2U50_RS27565	COG1476	TRANSCRIPTIONal
C2U50_RS27605	COG0582	viral genome integration into host DNA
C2U50_RS27630	COG1349	DNA-binding transcription factor activity
C2U50_RS27635	COG0494	nUDIX hydrolase
C2U50_RS27655	COG1061	Type III restriction enzyme res subunit
C2U50_RS27660	COG1187	pseudouridine synthase activity
C2U50_RS27665	COG2814	Major facilitator Superfamily
C2U50_RS27675	COG4172	Belongs to the ABC transporter superfamily
C2U50_RS27680	COG4239	(ABC) transporter, permease
C2U50_RS27685	COG4174	ABC transporter (Permease)
C2U50_RS27690	COG4166	transmembrane transport
C2U50_RS27695	COG2200	EAL domain
C2U50_RS27700	COG0791	NLP P60 protein
C2U50_RS27705	COG0671	phosphoesterase, PA-phosphatase related
C2U50_RS27710	COG0523	cobalamin synthesis protein
C2U50_RS27715	COG0246	Mannitol dehydrogenase
C2U50_RS27720	COG1312	Catalyzes the dehydration of D-mannonate
C2U50_RS27750	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U50_RS27750	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U50_RS27755	COG1105	Belongs to the carbohydrate kinase PfkB family
C2U50_RS27760	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C2U50_RS27760	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U50_RS27760	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U50_RS27770	COG2855	membrane
C2U50_RS27780	COG0583	DNA-binding transcription factor activity
C2U50_RS27785	COG0833	amino acid
C2U50_RS27795	COG4771	TonB-dependent receptor
C2U50_RS27810	COG2311	Membrane
C2U50_RS27825	COG1129	ABC transporter
C2U50_RS27835	COG2949	membrane
C2U50_RS27845	COG1346	cytolysis
C2U50_RS27855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2U50_RS27875	COG2723	6-phospho-beta-galactosidase activity
C2U50_RS27885	COG1538	Outer membrane efflux protein
C2U50_RS27890	COG0586	Pfam SNARE associated Golgi protein
C2U50_RS27900	COG1686	Belongs to the peptidase S11 family
C2U50_RS27910	COG0277	FAD linked oxidase domain protein
C2U50_RS27915	COG1472	Belongs to the glycosyl hydrolase 3 family
C2U50_RS27920	COG1732	Glycine betaine
C2U50_RS27925	COG1174	glycine betaine transport
C2U50_RS27930	COG1125	glycine betaine transport
C2U50_RS27935	COG1174	glycine betaine transport
C2U50_RS27945	COG3275	phosphorelay sensor kinase activity
C2U50_RS27955	COG4807	Protein conserved in bacteria
C2U50_RS27975	COG5455	response to cobalt ion
C2U50_RS27980	COG0583	DNA-binding transcription factor activity
C2U50_RS27985	COG2252	PERMEase
C2U50_RS27995	COG0583	DNA-binding transcription factor activity
C2U50_RS28010	COG0351	phosphomethylpyrimidine kinase
C2U50_RS28015	COG1830	Aldolase
C2U50_RS28050	COG1070	Carbohydrate kinase
C2U50_RS28060	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U50_RS28065	COG4948	Mandelate Racemase Muconate Lactonizing
C2U50_RS28070	COG0747	negative chemotaxis
C2U50_RS28075	COG0601	transmembrane transport
C2U50_RS28080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U50_RS28085	COG0444	Belongs to the ABC transporter superfamily
C2U50_RS28090	COG4608	Belongs to the ABC transporter superfamily
C2U50_RS28100	COG0826	peptidase U32
C2U50_RS28105	COG0745	RESPONSE REGULATOR receiver
C2U50_RS28110	COG2205	protein histidine kinase activity
C2U50_RS28135	COG1301	dicarboxylic acid transport
C2U50_RS28145	COG3039	Transposase
C2U50_RS28155	COG5002	protein histidine kinase activity
C2U50_RS28160	COG0443	Heat shock 70 kDa protein
C2U50_RS28170	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C2U50_RS28185	COG2982	Protein involved in outer membrane biogenesis
C2U50_RS28190	COG1253	flavin adenine dinucleotide binding
C2U50_RS28225	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C2U50_RS28250	COG1215	transferase activity, transferring glycosyl groups
C2U50_RS28265	COG1088	dTDP-glucose 4,6-dehydratase activity
C2U50_RS28320	COG0438	transferase activity, transferring glycosyl groups
C2U50_RS28325	COG1216	Glycosyl transferase, family 2
C2U50_RS28325	COG1442	glycosyl transferase family 8
C2U50_RS28335	COG0463	Glycosyl transferase, family 2
C2U50_RS28360	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C2U50_RS28390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2U50_RS28395	COG0583	DNA-binding transcription factor activity
C2U50_RS28405	COG0531	amino acid
C2U50_RS28410	COG0640	Transcriptional regulator
C2U50_RS28415	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C2U50_RS28420	COG2925	Exonuclease
C2U50_RS28435	COG3344	reverse transcriptase
C2U50_RS28445	COG1289	transmembrane transporter activity
C2U50_RS28465	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C2U50_RS28475	COG1942	4-Oxalocrotonate Tautomerase
C2U50_RS28480	COG0583	DNA-binding transcription factor activity
C2U50_RS28485	COG0095	Lipoate-protein ligase
C2U50_RS28490	COG0477	Major facilitator Superfamily
C2U50_RS28510	COG3385	transposase activity
C2U50_RS28525	COG3615	Tellurite resistance protein tehB
C2U50_RS28550	COG3706	GGDEF domain
C2U50_RS28570	COG0534	Mate efflux family protein
C2U50_RS28580	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2U50_RS28600	COG0604	alcohol dehydrogenase
C2U50_RS28605	COG1309	transcriptional regulator
C2U50_RS28610	COG0025	NhaP-type Na H and K H
C2U50_RS28660	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2U50_RS28670	COG1418	mRNA catabolic process
C2U50_RS28675	COG0270	DNA (cytosine-5-)-methyltransferase activity
C2U50_RS28680	COG3727	T/G mismatch-specific endonuclease activity
C2U50_RS28685	COG0697	spore germination
C2U50_RS28690	COG2354	Protein conserved in bacteria
C2U50_RS28720	COG0366	Alpha amylase catalytic
C2U50_RS28725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U50_RS28735	COG0765	amino acid transport
C2U50_RS28740	COG1126	abc transporter atp-binding protein
C2U50_RS28745	COG2197	response regulator
C2U50_RS28755	COG2197	response regulator
C2U50_RS28795	COG3012	SEC-C Motif Domain Protein
C2U50_RS28795	COG3318	Belongs to the UPF0149 family
C2U50_RS28800	COG0814	amino acid
C2U50_RS28810	COG1528	Iron-storage protein
C2U50_RS28825	COG0477	Major facilitator Superfamily
C2U50_RS28835	COG2211	Major facilitator Superfamily
C2U50_RS28845	COG1528	Iron-storage protein
C2U50_RS28855	COG1879	ABC-type sugar transport system periplasmic component
C2U50_RS28865	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U50_RS28890	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C2U50_RS28900	COG3102	Protein conserved in bacteria
C2U50_RS28920	COG3788	relative of glutathione S-transferase, MAPEG superfamily
C2U50_RS28925	COG1801	Protein of unknown function DUF72
C2U50_RS28930	COG0582	viral genome integration into host DNA
C2U50_RS29115	COG3772	lysozyme
C2U50_RS29285	COG1335	isochorismatase
C2U50_RS29295	COG0494	nUDIX hydrolase
C2U50_RS29320	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2U50_RS29330	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C2U50_RS29335	COG0739	heme binding
C2U50_RS29340	COG1560	Kdo2-lipid A biosynthetic process
C2U50_RS29350	COG1737	Transcriptional regulator
C2U50_RS29365	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C2U50_RS29370	COG0129	dihydroxy-acid dehydratase activity
C2U50_RS29375	COG0800	Aldolase
C2U50_RS29385	COG3141	response to X-ray
C2U50_RS29390	COG2979	Protein of unknown function (DUF533)
C2U50_RS29395	COG1770	oligopeptidase
C2U50_RS29400	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2U50_RS29410	COG2372	response to copper ion
C2U50_RS29415	COG1276	copper resistance
C2U50_RS29430	COG2990	Protein conserved in bacteria
C2U50_RS29455	COG3008	intermembrane lipid transfer
C2U50_RS29460	COG2995	paraquat-inducible protein a
C2U50_RS29465	COG1956	GAF domain-containing protein
C2U50_RS29485	COG2814	Major facilitator Superfamily
C2U50_RS29495	COG1414	Transcriptional regulator
C2U50_RS29540	COG0768	penicillin binding
C2U50_RS29545	COG2226	methyltransferase
C2U50_RS29560	COG3716	PTS system mannose fructose sorbose family IID component
C2U50_RS29565	COG3715	PTS system
C2U50_RS29570	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U50_RS29570	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U50_RS29575	COG1253	flavin adenine dinucleotide binding
C2U50_RS29580	COG2200	EAL domain
C2U50_RS29585	COG1760	l-serine dehydratase
C2U50_RS29605	COG0251	oxidation-reduction process
C2U50_RS29610	COG1199	ATP-dependent helicase activity
C2U50_RS29620	COG3065	identical protein binding
C2U50_RS29630	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C2U50_RS29640	COG2894	cell division
C2U50_RS29655	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2U50_RS29685	COG2719	SpoVR family
C2U50_RS29705	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2U50_RS29715	COG4774	siderophore transport
C2U50_RS29730	COG2308	Evidence 4 Homologs of previously reported genes of
C2U50_RS29775	COG0583	DNA-binding transcription factor activity
C2U50_RS29780	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2U50_RS29795	COG1882	Formate acetyltransferase
C2U50_RS29825	COG0583	DNA-binding transcription factor activity
C2U50_RS29855	COG0583	DNA-binding transcription factor activity
C2U50_RS29870	COG3122	Protein conserved in bacteria
C2U50_RS29900	COG2885	chlorophyll binding
C2U50_RS29905	COG3501	Rhs element vgr protein
C2U50_RS29965	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C2U50_RS30045	COG0012	GTP binding
C2U50_RS30065	COG0659	secondary active sulfate transmembrane transporter activity
C2U50_RS30100	COG2890	protein-(glutamine-N5) methyltransferase activity
C2U50_RS30120	COG0387	Pfam Sodium calcium exchanger
C2U50_RS30125	COG4572	Cation transport regulator
C2U50_RS30130	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
C2U50_RS30140	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C2U50_RS30145	COG3707	response regulator
C2U50_RS30150	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2U50_RS30160	COG1116	anion transmembrane transporter activity
C2U50_RS30165	COG2146	nitrite reductase [NAD(P)H] activity
C2U50_RS30165	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U50_RS30170	COG0243	molybdopterin cofactor binding
C2U50_RS30175	COG4932	domain protein
C2U50_RS30180	COG2197	response regulator
C2U50_RS30185	COG3850	Histidine kinase
C2U50_RS30190	COG2223	nitrite transmembrane transporter activity
C2U50_RS30195	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C2U50_RS30200	COG1140	nitrate reductase beta subunit
C2U50_RS30205	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C2U50_RS30210	COG2181	nitrate reductase activity
C2U50_RS30220	COG1522	sequence-specific DNA binding
C2U50_RS30250	COG0788	formyltetrahydrofolate deformylase activity
C2U50_RS30260	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2U50_RS30265	COG0745	RESPONSE REGULATOR receiver
C2U50_RS30270	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2U50_RS30275	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2U50_RS30280	COG1435	thymidine kinase activity
C2U50_RS30285	COG1454	alcohol dehydrogenase
C2U50_RS30285	COG1012	belongs to the aldehyde dehydrogenase family
C2U50_RS30295	COG2095	MarC family integral membrane protein
C2U50_RS30300	COG4166	transmembrane transport
C2U50_RS30305	COG0601	transmembrane transport
C2U50_RS30310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U50_RS30315	COG0444	Belongs to the ABC transporter superfamily
C2U50_RS30325	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2U50_RS30345	COG2353	YceI-like domain
C2U50_RS30350	COG2350	Protein conserved in bacteria
C2U50_RS30360	COG3001	Fructosamine kinase
C2U50_RS30370	COG1105	Belongs to the carbohydrate kinase PfkB family
C2U50_RS30375	COG3137	Salt-induced outer membrane protein
C2U50_RS30415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U50_RS30415	COG0072	phenylalanine-tRNA ligase activity
C2U50_RS30435	COG0583	DNA-binding transcription factor activity
C2U50_RS30455	COG0386	Belongs to the glutathione peroxidase family
C2U50_RS30465	COG0791	NLP P60 protein
C2U50_RS30475	COG4256	Hemin uptake protein
C2U50_RS30480	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U50_RS30490	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2U50_RS30490	COG0574	Belongs to the PEP-utilizing enzyme family
C2U50_RS30500	COG0628	permease
C2U50_RS30505	COG0247	lactate metabolic process
C2U50_RS30505	COG0277	FAD linked oxidase domain protein
C2U50_RS30510	COG2050	protein possibly involved in aromatic compounds catabolism
C2U50_RS30515	COG2261	transglycosylase associated protein
C2U50_RS30545	COG1120	ATPase activity
C2U50_RS30550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U50_RS30560	COG0583	DNA-binding transcription factor activity
C2U50_RS30585	COG1304	FMN binding
C2U50_RS30600	COG0316	Belongs to the HesB IscA family
C2U50_RS30605	COG0719	Fe-S assembly protein
C2U50_RS30610	COG0396	ATPase activity
C2U50_RS30615	COG0719	Fe-S assembly protein
C2U50_RS30630	COG1376	ErfK ybiS ycfS ynhG family protein
C2U50_RS30655	COG1309	transcriptional regulator
C2U50_RS30660	COG1082	Xylose isomerase domain protein TIM barrel
C2U50_RS30660	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C2U50_RS30665	COG2271	Major facilitator Superfamily
C2U50_RS30670	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2U50_RS30680	COG1120	ATPase activity
C2U50_RS30685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U50_RS30690	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2U50_RS30695	COG1414	Transcriptional regulator
C2U50_RS30730	COG2814	Major facilitator Superfamily
C2U50_RS30750	COG0583	DNA-binding transcription factor activity
C2U50_RS30755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U50_RS30775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U50_RS30780	COG1116	anion transmembrane transporter activity
C2U50_RS30785	COG4774	siderophore transport
C2U50_RS30790	COG1120	ATPase activity
C2U50_RS30795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U50_RS30800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U50_RS30820	COG0765	amino acid transport
C2U50_RS30825	COG1126	abc transporter atp-binding protein
C2U50_RS30855	COG1473	amidohydrolase
C2U50_RS30860	COG3383	formate dehydrogenase (NAD+) activity
C2U50_RS30865	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C2U50_RS30880	COG1175	transmembrane transport
C2U50_RS30910	COG4133	protoheme IX ABC transporter activity
C2U50_RS30915	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2U50_RS30920	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2U50_RS30935	COG1138	Cytochrome C-type biogenesis protein
C2U50_RS30940	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2U50_RS30945	COG3088	subunit of a heme lyase
C2U50_RS30945	COG4235	cytochrome complex assembly
C2U50_RS30985	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
C2U50_RS30995	COG3039	Transposase
C2U50_RS31015	COG3850	Histidine kinase
C2U50_RS31015	COG5002	protein histidine kinase activity
C2U50_RS31020	COG0745	RESPONSE REGULATOR receiver
C2U50_RS31030	COG3039	Transposase
C2U50_RS31050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U50_RS31085	COG1028	Short-chain dehydrogenase reductase Sdr
C2U50_RS31090	COG2610	gluconate transmembrane transporter activity
C2U50_RS31095	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U50_RS31105	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2U50_RS31115	COG0583	DNA-binding transcription factor activity
C2U50_RS31145	COG2814	Major facilitator Superfamily
C2U50_RS31160	COG0277	FAD linked oxidase domain protein
C2U50_RS31165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U50_RS31190	COG0402	S-adenosylhomocysteine deaminase activity
C2U50_RS31250	COG4608	Belongs to the ABC transporter superfamily
C2U50_RS31255	COG0444	Belongs to the ABC transporter superfamily
C2U50_RS31280	COG0346	lactoylglutathione lyase activity
C2U50_RS31285	COG1349	DNA-binding transcription factor activity
C2U50_RS31315	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C2U50_RS31335	COG0300	oxidoreductase activity
C2U50_RS31375	COG0307	riboflavin synthase, alpha
C2U50_RS31380	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2U50_RS31385	COG2814	Major facilitator Superfamily
C2U50_RS31390	COG0583	DNA-binding transcription factor activity
C2U50_RS31405	COG2814	Major facilitator Superfamily
C2U50_RS31420	COG0791	NLP P60 protein
C2U50_RS31425	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C2U50_RS31435	COG0346	lactoylglutathione lyase activity
C2U50_RS31440	COG1902	pentaerythritol trinitrate reductase activity
C2U50_RS31445	COG1309	transcriptional regulator
C2U50_RS31450	COG3313	Fe-S protein
C2U50_RS31455	COG4989	oxidoreductase activity
C2U50_RS31460	COG2032	superoxide dismutase activity
C2U50_RS31465	COG1289	transmembrane transporter activity
C2U50_RS31470	COG1566	PFAM secretion protein HlyD family protein
C2U50_RS31485	COG3706	GGDEF domain
C2U50_RS31500	COG3895	Periplasmic Protein
C2U50_RS31515	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C2U50_RS31520	COG0625	glutathione transferase activity
C2U50_RS31535	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C2U50_RS31545	COG4659	FMN binding
C2U50_RS31580	COG2723	6-phospho-beta-galactosidase activity
C2U50_RS31590	COG0673	inositol 2-dehydrogenase activity
C2U50_RS31600	COG2814	Major facilitator Superfamily
C2U50_RS31620	COG3038	cytochrome b561
C2U50_RS31640	COG0583	DNA-binding transcription factor activity
C2U50_RS31645	COG3485	protocatechuate 3,4-dioxygenase
C2U50_RS31650	COG3485	protocatechuate 3,4-dioxygenase
C2U50_RS31655	COG5383	Protein conserved in bacteria
C2U50_RS31660	COG2272	Belongs to the type-B carboxylesterase lipase family
C2U50_RS31675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2U50_RS31680	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2U50_RS31685	COG1275	C4-dicarboxylate transporter malic acid transport protein
C2U50_RS31690	COG0500	methyltransferase
C2U50_RS31705	COG2207	Transcriptional regulator
C2U50_RS31705	COG3708	Transcriptional regulator
C2U50_RS31710	COG3135	benzoate transporter
C2U50_RS31715	COG1396	sequence-specific DNA binding
C2U50_RS31725	COG0826	peptidase U32
C2U50_RS31740	COG1294	oxidase, subunit
C2U50_RS31745	COG1271	oxidase subunit
C2U50_RS31750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U50_RS31755	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C2U50_RS31760	COG3842	ATPase activity
C2U50_RS31765	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2U50_RS31770	COG1177	transmembrane transport
C2U50_RS31775	COG1012	belongs to the aldehyde dehydrogenase family
C2U50_RS31805	COG1012	belongs to the aldehyde dehydrogenase family
C2U50_RS31810	COG0747	negative chemotaxis
C2U50_RS31820	COG3238	Protein conserved in bacteria
C2U50_RS31825	COG1247	-acetyltransferase
C2U50_RS31835	COG2130	NADP-dependent
C2U50_RS31845	COG3691	Protein conserved in bacteria
C2U50_RS31850	COG1228	amidohydrolase
C2U50_RS31855	COG4772	TonB-dependent receptor
C2U50_RS31885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U50_RS31890	COG1473	amidohydrolase
C2U50_RS31895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U50_RS31900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U50_RS31910	COG0765	amino acid transport
C2U50_RS31915	COG1126	abc transporter atp-binding protein
C2U50_RS31925	COG0625	glutathione transferase activity
C2U50_RS31940	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2U50_RS31945	COG3842	ATPase activity
C2U50_RS31950	COG1840	ABC-type Fe3 transport system, periplasmic component
C2U50_RS31955	COG1178	ABC-type Fe3 transport system permease component
C2U50_RS31960	COG2162	N-hydroxyarylamine O-acetyltransferase activity
C2U50_RS31965	COG2181	nitrate reductase activity
C2U50_RS31970	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C2U50_RS31975	COG1140	nitrate reductase beta subunit
C2U50_RS31980	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C2U50_RS31985	COG2223	nitrite transmembrane transporter activity
C2U50_RS32000	COG1414	Transcriptional regulator
C2U50_RS32005	COG4948	Mandelate Racemase Muconate Lactonizing
C2U50_RS32010	COG4829	muconolactone delta-isomerase
C2U50_RS32015	COG3485	protocatechuate 3,4-dioxygenase
C2U50_RS32025	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C2U50_RS32045	COG3383	formate dehydrogenase (NAD+) activity
C2U50_RS32045	COG0243	molybdopterin cofactor binding
C2U50_RS32050	COG0243	molybdopterin cofactor binding
C2U50_RS32050	COG3383	formate dehydrogenase (NAD+) activity
C2U50_RS32055	COG0437	4 iron, 4 sulfur cluster binding
C2U50_RS32060	COG2864	formate dehydrogenase
C2U50_RS32075	COG2326	polyphosphate kinase activity
C2U50_RS32085	COG2814	Major facilitator Superfamily
C2U50_RS32095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U50_RS32105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U50_RS32115	COG0747	negative chemotaxis
C2U50_RS32120	COG1064	alcohol dehydrogenase
C2U50_RS32135	COG0488	(ABC) transporter
C2U50_RS32175	COG1028	Short-chain dehydrogenase reductase Sdr
C2U50_RS32180	COG3729	General stress protein
C2U50_RS32200	COG3685	Protein conserved in bacteria
C2U50_RS32210	COG0366	Alpha amylase catalytic
C2U50_RS32220	COG2323	membrane
C2U50_RS32230	COG3111	PFAM Bacterial OB fold (BOF) protein
C2U50_RS32235	COG1764	response to oxidative stress
C2U50_RS32260	COG3781	membrane
C2U50_RS32265	COG0243	molybdopterin cofactor binding
C2U50_RS32270	COG0583	DNA-binding transcription factor activity
C2U50_RS32275	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2U50_RS32280	COG2814	Major facilitator Superfamily
C2U50_RS32290	COG1285	pathogenesis
C2U50_RS32295	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C2U50_RS32315	COG0519	Catalyzes the synthesis of GMP from XMP
C2U50_RS32315	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2U50_RS32355	COG0596	Alpha beta hydrolase
C2U50_RS32365	COG2205	protein histidine kinase activity
C2U50_RS32380	COG0076	glutamate decarboxylase activity
C2U50_RS32385	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2U50_RS32390	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2U50_RS32395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U50_RS32400	COG1116	anion transmembrane transporter activity
C2U50_RS32405	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C2U50_RS32420	COG0673	inositol 2-dehydrogenase activity
C2U50_RS32430	COG1609	Transcriptional regulator
C2U50_RS32435	COG3706	GGDEF domain
C2U50_RS32440	COG0402	S-adenosylhomocysteine deaminase activity
C2U50_RS32445	COG1953	Uracil, thiamine, allantoin
C2U50_RS32480	COG0406	alpha-ribazole phosphatase activity
C2U50_RS32490	COG1335	isochorismatase
C2U50_RS32530	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2U50_RS32595	COG0765	amino acid transport
C2U50_RS32605	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C2U50_RS32615	COG2070	2-Nitropropane dioxygenase
C2U50_RS32620	COG0583	DNA-binding transcription factor activity
C2U50_RS32630	COG1902	pentaerythritol trinitrate reductase activity
C2U50_RS32635	COG4529	Protein conserved in bacteria
C2U50_RS32640	COG0477	Major facilitator Superfamily
C2U50_RS32670	COG2223	nitrite transmembrane transporter activity
C2U50_RS32680	COG1609	Transcriptional regulator
C2U50_RS32685	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U50_RS32695	COG3037	sugar-specific permease SgaT UlaA