locus-tag	class	description
H1D28_RS00060	COG1106	Psort location Cytoplasmic, score
H1D28_RS00110	COG2161	toxin-antitoxin pair type II binding
H1D28_RS00115	COG4115	mRNA cleavage
H1D28_RS00170	COG0697	spore germination
H1D28_RS00255	COG3344	reverse transcriptase
H1D28_RS00360	COG2203	Gaf domain
H1D28_RS00360	COG2199	diguanylate cyclase activity
H1D28_RS00365	COG1716	ATPase activity
H1D28_RS00365	COG5001	Diguanylate cyclase
H1D28_RS00410	COG2223	nitrite transmembrane transporter activity
H1D28_RS00420	COG1609	Transcriptional regulator
H1D28_RS00455	COG0431	NADPH-dependent FMN reductase
H1D28_RS00460	COG0640	Transcriptional regulator
H1D28_RS00485	COG3436	PFAM IS66 Orf2 family protein
H1D28_RS00490	COG1120	ATPase activity
H1D28_RS00495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1D28_RS00500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1D28_RS00505	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H1D28_RS00515	COG3712	iron ion homeostasis
H1D28_RS00520	COG1595	DNA-templated transcription, initiation
H1D28_RS00535	COG0583	DNA-binding transcription factor activity
H1D28_RS00555	COG4598	ABC transporter
H1D28_RS00600	COG3706	GGDEF domain
H1D28_RS00635	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1D28_RS00665	COG0739	heme binding
H1D28_RS00675	COG2132	Multicopper oxidase
H1D28_RS00680	COG3667	copper resistance
H1D28_RS00685	COG2372	response to copper ion
H1D28_RS00690	COG1276	copper resistance
H1D28_RS00695	COG0745	RESPONSE REGULATOR receiver
H1D28_RS00700	COG2205	protein histidine kinase activity
H1D28_RS00765	COG1196	nuclear chromosome segregation
H1D28_RS01035	COG5499	transcription regulator containing HTH domain
H1D28_RS01105	COG1475	DNA binding
H1D28_RS01280	COG1324	tolerance protein
H1D28_RS01285	COG0673	inositol 2-dehydrogenase activity
H1D28_RS01390	COG0789	Transcriptional regulator
H1D28_RS01445	COG4372	Transposase
H1D28_RS01450	COG3436	PFAM IS66 Orf2 family protein
H1D28_RS01470	COG4245	von Willebrand factor, type A
H1D28_RS01475	COG4245	von Willebrand factor, type A
H1D28_RS01485	COG4245	von Willebrand factor, type A
H1D28_RS01505	COG1358	cellular component organization or biogenesis
H1D28_RS01605	COG2916	Histone family protein nucleoid-structuring protein H-NS
H1D28_RS01685	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H1D28_RS01835	COG5654	RES domain protein
H1D28_RS01840	COG5642	Protein of unknown function (DUF2384)
H1D28_RS01875	COG3576	pyridoxamine 5-phosphate
H1D28_RS01880	COG1199	ATP-dependent helicase activity
H1D28_RS01880	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H1D28_RS02095	COG3173	Aminoglycoside phosphotransferase
H1D28_RS02115	COG0482	sulfurtransferase activity
H1D28_RS02200	COG3344	reverse transcriptase
H1D28_RS02310	COG0210	DNA helicase
H1D28_RS02320	COG2026	Addiction module toxin, RelE StbE family
H1D28_RS02330	COG0675	Transposase, IS605 OrfB family
H1D28_RS02345	COG0675	Transposase, IS605 OrfB family
H1D28_RS02585	COG1484	DNA-dependent DNA replication
H1D28_RS02610	COG3039	Transposase
H1D28_RS02625	COG0633	Ferredoxin
H1D28_RS02685	COG0187	DNA topoisomerase II activity
H1D28_RS02690	COG0561	phosphatase activity
H1D28_RS02705	COG2186	Transcriptional regulator
H1D28_RS02710	COG3734	2-keto-3-deoxy-galactonokinase
H1D28_RS02715	COG0800	Aldolase
H1D28_RS02725	COG2271	Major facilitator Superfamily
H1D28_RS02730	COG0823	Involved in the tonB-independent uptake of proteins
H1D28_RS02735	COG5645	(Lipo)protein
H1D28_RS02760	COG2188	Transcriptional regulator
H1D28_RS02775	COG2149	membrane
H1D28_RS02795	COG2610	gluconate transmembrane transporter activity
H1D28_RS02805	COG0583	DNA-binding transcription factor activity
H1D28_RS02810	COG2814	Major facilitator Superfamily
H1D28_RS02840	COG0028	Belongs to the TPP enzyme family
H1D28_RS02845	COG0440	acetolactate synthase activity
H1D28_RS02850	COG2197	response regulator
H1D28_RS02860	COG2271	Major facilitator Superfamily
H1D28_RS02900	COG2188	Transcriptional regulator
H1D28_RS02925	COG4580	involved in the transport of maltose and maltodextrins
H1D28_RS02930	COG1447	Phosphotransferase system cellobiose-specific component IIA
H1D28_RS02935	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H1D28_RS02935	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H1D28_RS02945	COG1609	Transcriptional regulator
H1D28_RS02955	COG3384	dioxygenase
H1D28_RS02960	COG0583	DNA-binding transcription factor activity
H1D28_RS02965	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H1D28_RS02970	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H1D28_RS02975	COG2828	Protein conserved in bacteria
H1D28_RS02990	COG0697	spore germination
H1D28_RS02995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H1D28_RS02995	COG1263	PTS System
H1D28_RS03005	COG2814	Major facilitator Superfamily
H1D28_RS03015	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H1D28_RS03050	COG0583	DNA-binding transcription factor activity
H1D28_RS03075	COG1464	Belongs to the NlpA lipoprotein family
H1D28_RS03090	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H1D28_RS03100	COG1064	alcohol dehydrogenase
H1D28_RS03160	COG2211	Major facilitator Superfamily
H1D28_RS03165	COG1501	Belongs to the glycosyl hydrolase 31 family
H1D28_RS03175	COG1486	melibiose metabolic process
H1D28_RS03180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H1D28_RS03180	COG1263	PTS System
H1D28_RS03185	COG2982	Protein involved in outer membrane biogenesis
H1D28_RS03190	COG2233	PERMEase
H1D28_RS03195	COG0786	glutamate:sodium symporter activity
H1D28_RS03215	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H1D28_RS03240	COG3152	Membrane
H1D28_RS03250	COG1494	fructose-1,6-bisphosphatase
H1D28_RS03255	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H1D28_RS03260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H1D28_RS03265	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H1D28_RS03285	COG2860	membrane
H1D28_RS03295	COG2169	Transcriptional regulator
H1D28_RS03295	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H1D28_RS03305	COG1561	YicC-like family, N-terminal region
H1D28_RS03325	COG1131	(ABC) transporter
H1D28_RS03330	COG0842	Transport permease protein
H1D28_RS03355	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H1D28_RS03390	COG1519	Transferase
H1D28_RS03395	COG1216	Glycosyl transferase, family 2
H1D28_RS03400	COG0438	transferase activity, transferring glycosyl groups
H1D28_RS03410	COG0859	PFAM glycosyl transferase family 9
H1D28_RS03435	COG0859	PFAM glycosyl transferase family 9
H1D28_RS03450	COG0156	8-amino-7-oxononanoate synthase activity
H1D28_RS03460	COG0463	Glycosyl transferase, family 2
H1D28_RS03465	COG2861	carbohydrate metabolic process
H1D28_RS03470	COG4942	peptidase
H1D28_RS03480	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H1D28_RS03485	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H1D28_RS03505	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H1D28_RS03515	COG2186	Transcriptional regulator
H1D28_RS03535	COG3722	fumarate hydratase activity
H1D28_RS03555	COG1566	PFAM secretion protein HlyD family protein
H1D28_RS03560	COG0625	glutathione transferase activity
H1D28_RS03570	COG3276	selenocysteine insertion sequence binding
H1D28_RS03575	COG1414	Transcriptional regulator
H1D28_RS03580	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H1D28_RS03585	COG3977	Valine--pyruvate aminotransferase
H1D28_RS03590	COG0366	Alpha amylase catalytic
H1D28_RS03595	COG2992	FlgJ-related protein
H1D28_RS03600	COG1609	Transcriptional regulator
H1D28_RS03600	COG2207	Transcriptional regulator
H1D28_RS03605	COG4214	carbohydrate transport
H1D28_RS03615	COG4213	ABC transporter substrate-binding protein
H1D28_RS03630	COG4682	membrane
H1D28_RS03635	COG4682	membrane
H1D28_RS03640	COG3274	enterobacterial common antigen metabolic process
H1D28_RS03675	COG1278	Cold shock
H1D28_RS03680	COG2944	sequence-specific DNA binding
H1D28_RS03685	COG2814	Major facilitator Superfamily
H1D28_RS03705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H1D28_RS03715	COG1609	Transcriptional regulator
H1D28_RS03720	COG2885	chlorophyll binding
H1D28_RS03725	COG0243	molybdopterin cofactor binding
H1D28_RS03730	COG0456	acetyltransferase
H1D28_RS03735	COG2818	Glycosylase
H1D28_RS03740	COG5571	outer membrane autotransporter
H1D28_RS03745	COG2223	nitrite transmembrane transporter activity
H1D28_RS03770	COG0747	negative chemotaxis
H1D28_RS03775	COG0601	transmembrane transport
H1D28_RS03780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1D28_RS03785	COG0444	Belongs to the ABC transporter superfamily
H1D28_RS03790	COG4608	Belongs to the ABC transporter superfamily
H1D28_RS03805	COG2894	cell division
H1D28_RS03815	COG1215	transferase activity, transferring glycosyl groups
H1D28_RS03820	COG0457	Tetratricopeptide repeat
H1D28_RS03835	COG2194	sulfuric ester hydrolase activity
H1D28_RS03865	COG1215	transferase activity, transferring glycosyl groups
H1D28_RS03870	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
H1D28_RS03875	COG3118	belongs to the thioredoxin family
H1D28_RS03875	COG0457	Tetratricopeptide repeat
H1D28_RS03880	COG2200	EAL domain
H1D28_RS03880	COG2199	diguanylate cyclase activity
H1D28_RS03890	COG0612	Peptidase, M16
H1D28_RS03900	COG2982	Protein involved in outer membrane biogenesis
H1D28_RS03905	COG0477	Major facilitator Superfamily
H1D28_RS03910	COG1295	ribonuclease BN
H1D28_RS03915	COG0583	DNA-binding transcription factor activity
H1D28_RS03920	COG1028	Short-chain dehydrogenase reductase Sdr
H1D28_RS03925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H1D28_RS03935	COG1454	alcohol dehydrogenase
H1D28_RS03945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H1D28_RS03950	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H1D28_RS03955	COG0671	phosphoesterase, PA-phosphatase related
H1D28_RS03975	COG0589	response to stress
H1D28_RS03985	COG0306	phosphate transporter
H1D28_RS03990	COG2081	HI0933 family
H1D28_RS03995	COG2239	Acts as a magnesium transporter
H1D28_RS04005	COG1124	(ABC) transporter
H1D28_RS04015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1D28_RS04020	COG0601	transmembrane transport
H1D28_RS04025	COG0747	negative chemotaxis
H1D28_RS04035	COG3479	Phenolic acid decarboxylase
H1D28_RS04075	COG0628	permease
H1D28_RS04080	COG0477	Major facilitator Superfamily
H1D28_RS04090	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H1D28_RS04105	COG3714	YhhN family
H1D28_RS04115	COG3776	membrane
H1D28_RS04120	COG0742	ribosomal rna small subunit methyltransferase
H1D28_RS04125	COG0552	protein localization to endoplasmic reticulum
H1D28_RS04130	COG2884	Cell division ATP-binding protein ftsE
H1D28_RS04135	COG2177	Part of the ABC transporter FtsEX involved in
H1D28_RS04150	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H1D28_RS04160	COG0683	leucine binding
H1D28_RS04170	COG0683	leucine binding
H1D28_RS04175	COG0559	Belongs to the binding-protein-dependent transport system permease family
H1D28_RS04225	COG0584	glycerophosphoryl diester phosphodiesterase
H1D28_RS04235	COG0405	Gamma-glutamyltransferase
H1D28_RS04240	COG1247	-acetyltransferase
H1D28_RS04250	COG0673	inositol 2-dehydrogenase activity
H1D28_RS04255	COG1741	Belongs to the pirin family
H1D28_RS04260	COG1609	Transcriptional regulator
H1D28_RS04265	COG3265	gluconokinase activity
H1D28_RS04270	COG2610	gluconate transmembrane transporter activity
H1D28_RS04280	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H1D28_RS04305	COG0058	SHG alpha-glucan phosphorylase activity
H1D28_RS04320	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H1D28_RS04335	COG1349	DNA-binding transcription factor activity
H1D28_RS04345	COG0058	SHG alpha-glucan phosphorylase activity
H1D28_RS04350	COG1640	4-alpha-glucanotransferase
H1D28_RS04355	COG2610	gluconate transmembrane transporter activity
H1D28_RS04365	COG1040	competence protein
H1D28_RS04390	COG1918	ferrous iron import across plasma membrane
H1D28_RS04395	COG2183	response to ionizing radiation
H1D28_RS04400	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H1D28_RS04405	COG0745	RESPONSE REGULATOR receiver
H1D28_RS04425	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H1D28_RS04430	COG1011	Hydrolase
H1D28_RS04440	COG0494	nUDIX hydrolase
H1D28_RS04445	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H1D28_RS04470	COG4796	Type ii and iii secretion system protein
H1D28_RS04485	COG3266	domain, Protein
H1D28_RS04490	COG0338	D12 class N6 adenine-specific DNA methyltransferase
H1D28_RS04495	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H1D28_RS04520	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1D28_RS04525	COG0402	S-adenosylhomocysteine deaminase activity
H1D28_RS04530	COG0738	Major facilitator superfamily
H1D28_RS04555	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H1D28_RS04560	COG1289	transmembrane transporter activity
H1D28_RS04570	COG1765	OsmC-like protein
H1D28_RS04575	COG3954	Phosphoribulokinase
H1D28_RS04585	COG0429	hydrolase of the alpha beta-hydrolase fold
H1D28_RS04590	COG0488	(ABC) transporter
H1D28_RS04605	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H1D28_RS04610	COG1047	Peptidyl-prolyl cis-trans
H1D28_RS04620	COG0545	Peptidyl-prolyl cis-trans isomerase
H1D28_RS04625	COG2964	Protein conserved in bacteria
H1D28_RS04680	COG0051	transcription antitermination factor activity, RNA binding
H1D28_RS04705	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H1D28_RS04720	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H1D28_RS04785	COG0201	protein transport
H1D28_RS04810	COG0202	RNA polymerase activity
H1D28_RS04825	COG0789	Transcriptional regulator
H1D28_RS04830	COG3036	rescue of stalled ribosome
H1D28_RS04860	COG0758	DNA mediated transformation
H1D28_RS04870	COG0551	DNA topoisomerase type I activity
H1D28_RS04890	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H1D28_RS04925	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H1D28_RS04930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1D28_RS04935	COG1309	transcriptional regulator
H1D28_RS04955	COG4145	pantothenate transmembrane transporter activity
H1D28_RS04960	COG3924	membrane
H1D28_RS04965	COG0439	Biotin carboxylase
H1D28_RS04970	COG0511	ligase activity, forming carbon-carbon bonds
H1D28_RS04995	COG2200	EAL domain
H1D28_RS04995	COG2199	diguanylate cyclase activity
H1D28_RS05000	COG1077	Cell shape determining protein MreB Mrl
H1D28_RS05005	COG1792	Involved in formation and maintenance of cell shape
H1D28_RS05010	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H1D28_RS05020	COG1530	ribonuclease E activity
H1D28_RS05025	COG3164	Protein of unknown function
H1D28_RS05030	COG0312	modulator of DNA gyrase
H1D28_RS05035	COG0583	DNA-binding transcription factor activity
H1D28_RS05050	COG1289	transmembrane transporter activity
H1D28_RS05055	COG2732	(Barnase) inhibitor
H1D28_RS05090	COG0471	metal ion transport
H1D28_RS05095	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H1D28_RS05100	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H1D28_RS05125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H1D28_RS05130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H1D28_RS05135	COG3105	Protein conserved in bacteria
H1D28_RS05140	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H1D28_RS05160	COG0625	glutathione transferase activity
H1D28_RS05165	COG2969	positive regulation of protein catabolic process
H1D28_RS05175	COG0493	'glutamate synthase
H1D28_RS05180	COG0069	glutamate synthase activity
H1D28_RS05180	COG0067	glutamate synthase
H1D28_RS05180	COG0070	glutamate synthase
H1D28_RS05185	COG1242	4 iron, 4 sulfur cluster binding
H1D28_RS05190	COG2271	Major facilitator Superfamily
H1D28_RS05195	COG1063	alcohol dehydrogenase
H1D28_RS05200	COG1312	Catalyzes the dehydration of D-mannonate
H1D28_RS05205	COG5002	protein histidine kinase activity
H1D28_RS05205	COG0784	Response regulator, receiver
H1D28_RS05205	COG2198	Histidine kinase
H1D28_RS05210	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
H1D28_RS05215	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H1D28_RS05220	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H1D28_RS05230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H1D28_RS05235	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H1D28_RS05240	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H1D28_RS05245	COG1137	ATPase activity
H1D28_RS05250	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H1D28_RS05255	COG3117	lipopolysaccharide transmembrane transporter activity
H1D28_RS05260	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H1D28_RS05270	COG0530	calcium, potassium:sodium antiporter activity
H1D28_RS05275	COG1127	ABC transporter
H1D28_RS05280	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H1D28_RS05285	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H1D28_RS05290	COG2854	intermembrane phospholipid transfer
H1D28_RS05295	COG3113	response to antibiotic
H1D28_RS05300	COG5007	Belongs to the BolA IbaG family
H1D28_RS05310	COG3423	Transcriptional regulator
H1D28_RS05315	COG0142	geranyltranstransferase activity
H1D28_RS05330	COG0697	spore germination
H1D28_RS05340	COG2027	D-alanyl-D-alanine carboxypeptidase
H1D28_RS05350	COG1534	Rna-binding protein
H1D28_RS05360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H1D28_RS05365	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H1D28_RS05375	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H1D28_RS05415	COG0195	Participates in both transcription termination and antitermination
H1D28_RS05460	COG0814	amino acid
H1D28_RS05465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1D28_RS05470	COG0826	peptidase U32
H1D28_RS05475	COG0826	peptidase U32
H1D28_RS05480	COG3154	lipid carrier protein
H1D28_RS05485	COG3153	acetyltransferase
H1D28_RS05500	COG0693	protein deglycase activity
H1D28_RS05505	COG0702	epimerase
H1D28_RS05510	COG0701	Predicted permease
H1D28_RS05515	COG2823	Periplasmic or secreted lipoprotein
H1D28_RS05535	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H1D28_RS05540	COG2721	sulfolactate sulfo-lyase activity
H1D28_RS05545	COG2271	Major facilitator Superfamily
H1D28_RS05555	COG2084	Dehydrogenase
H1D28_RS05560	COG1929	Belongs to the glycerate kinase type-1 family
H1D28_RS05585	COG1741	Belongs to the pirin family
H1D28_RS05590	COG0583	DNA-binding transcription factor activity
H1D28_RS05595	COG3152	Membrane
H1D28_RS05600	COG0435	Glutathione S-transferase
H1D28_RS05605	COG2259	Doxx family
H1D28_RS05615	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
H1D28_RS05620	COG4575	ribosome binding
H1D28_RS05625	COG1422	Protein of unknown function (DUF1090)
H1D28_RS05635	COG0586	Pfam SNARE associated Golgi protein
H1D28_RS05640	COG2186	Transcriptional regulator
H1D28_RS05645	COG2271	Major facilitator Superfamily
H1D28_RS05655	COG2721	sulfolactate sulfo-lyase activity
H1D28_RS05670	COG0861	Integral membrane protein TerC family
H1D28_RS05675	COG0673	inositol 2-dehydrogenase activity
H1D28_RS05680	COG1451	nucleotide metabolic process
H1D28_RS05700	COG0446	pyridine nucleotide-disulphide oxidoreductase
H1D28_RS05700	COG1902	pentaerythritol trinitrate reductase activity
H1D28_RS05750	COG1695	Transcriptional regulator
H1D28_RS05755	COG2375	cellular response to nickel ion
H1D28_RS05770	COG1461	Dihydroxyacetone kinase
H1D28_RS05775	COG2376	Dihydroxyacetone kinase
H1D28_RS05845	COG3247	response to pH
H1D28_RS05855	COG2205	protein histidine kinase activity
H1D28_RS05855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1D28_RS05855	COG0784	Response regulator, receiver
H1D28_RS05855	COG2198	Histidine kinase
H1D28_RS05860	COG2197	response regulator
H1D28_RS05880	COG4974	Belongs to the 'phage' integrase family
H1D28_RS05915	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H1D28_RS05955	COG4695	Portal protein
H1D28_RS06115	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H1D28_RS06120	COG0358	DNA primase activity
H1D28_RS06125	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H1D28_RS06190	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H1D28_RS06205	COG4991	sh3 domain protein
H1D28_RS06210	COG3025	triphosphatase activity
H1D28_RS06235	COG2960	long-chain fatty acid transporting porin activity
H1D28_RS06250	COG3384	dioxygenase
H1D28_RS06255	COG0754	glutathionylspermidine amidase activity
H1D28_RS06270	COG0494	nUDIX hydrolase
H1D28_RS06275	COG3151	Protein conserved in bacteria
H1D28_RS06280	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H1D28_RS06285	COG3150	esterase
H1D28_RS06295	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H1D28_RS06300	COG2249	NAD(P)H dehydrogenase (quinone) activity
H1D28_RS06305	COG0642	Histidine kinase
H1D28_RS06315	COG3111	PFAM Bacterial OB fold (BOF) protein
H1D28_RS06320	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
H1D28_RS06325	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H1D28_RS06330	COG0204	Acyl-transferase
H1D28_RS06335	COG2132	Multicopper oxidase
H1D28_RS06340	COG1032	radical SAM domain protein
H1D28_RS06350	COG0656	L-ascorbic acid biosynthetic process
H1D28_RS06355	COG1979	alcohol dehydrogenase
H1D28_RS06360	COG2207	Transcriptional regulator
H1D28_RS06365	COG0586	Pfam SNARE associated Golgi protein
H1D28_RS06370	COG0626	cystathionine gamma-synthase activity
H1D28_RS06380	COG0848	biopolymer transport protein
H1D28_RS06385	COG2211	Major facilitator Superfamily
H1D28_RS06410	COG0625	glutathione transferase activity
H1D28_RS06425	COG0754	glutathionylspermidine amidase activity
H1D28_RS06430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1D28_RS06450	COG0583	DNA-binding transcription factor activity
H1D28_RS06455	COG0626	cystathionine gamma-synthase activity
H1D28_RS06470	COG1811	Na channel or pump
H1D28_RS06475	COG1982	Orn Lys Arg decarboxylase major
H1D28_RS06480	COG2211	Major facilitator Superfamily
H1D28_RS06495	COG1194	a g-specific adenine glycosylase
H1D28_RS06505	COG3171	Protein conserved in bacteria
H1D28_RS06515	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H1D28_RS06530	COG0762	integral membrane protein
H1D28_RS06535	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H1D28_RS06540	COG2805	Type II/IV secretion system protein
H1D28_RS06560	COG0189	ligase activity
H1D28_RS06565	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H1D28_RS06570	COG2356	endonuclease I
H1D28_RS06580	COG2814	Major facilitator Superfamily
H1D28_RS06615	COG2146	nitrite reductase [NAD(P)H] activity
H1D28_RS06630	COG1028	Short-chain dehydrogenase reductase Sdr
H1D28_RS06635	COG1414	Transcriptional regulator
H1D28_RS06665	COG1028	Short-chain dehydrogenase reductase Sdr
H1D28_RS06670	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
H1D28_RS06690	COG0501	Belongs to the peptidase M48B family
H1D28_RS06695	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H1D28_RS06710	COG0191	fructose-bisphosphate aldolase activity
H1D28_RS06715	COG0668	transmembrane transport
H1D28_RS06725	COG2968	Membrane
H1D28_RS06740	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H1D28_RS06745	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H1D28_RS06765	COG0006	proline dipeptidase activity
H1D28_RS06770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1D28_RS06775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1D28_RS06795	COG1028	Short-chain dehydrogenase reductase Sdr
H1D28_RS06805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H1D28_RS06825	COG2723	6-phospho-beta-galactosidase activity
H1D28_RS06830	COG1737	Transcriptional regulator
H1D28_RS06840	COG1272	protein, Hemolysin III
H1D28_RS06850	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H1D28_RS06860	COG0716	FMN binding
H1D28_RS06865	COG4974	Belongs to the 'phage' integrase family
H1D28_RS06875	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H1D28_RS06895	COG4942	peptidase
H1D28_RS06905	COG2814	Major facilitator Superfamily
H1D28_RS06925	COG0667	Aldo Keto reductase
H1D28_RS06965	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H1D28_RS06970	COG1393	Belongs to the ArsC family
H1D28_RS06975	COG3104	oligopeptide transport
H1D28_RS06985	COG1538	Outer membrane efflux protein
H1D28_RS06990	COG1289	transmembrane transporter activity
H1D28_RS07005	COG3592	Divergent 4Fe-4S mono-cluster
H1D28_RS07010	COG2388	GCN5-related N-acetyl-transferase
H1D28_RS07020	COG3539	Fimbrial protein
H1D28_RS07025	COG3539	Fimbrial protein
H1D28_RS07030	COG3539	Fimbrial protein
H1D28_RS07035	COG3188	usher protein
H1D28_RS07040	COG3121	Chaperone
H1D28_RS07045	COG3539	Fimbrial protein
H1D28_RS07055	COG4974	Belongs to the 'phage' integrase family
H1D28_RS07060	COG0582	viral genome integration into host DNA
H1D28_RS07065	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
H1D28_RS07070	COG1846	Transcriptional regulator
H1D28_RS07075	COG0697	spore germination
H1D28_RS07125	COG0667	Aldo Keto reductase
H1D28_RS07130	COG0814	amino acid
H1D28_RS07145	COG0183	Belongs to the thiolase family
H1D28_RS07155	COG0823	Involved in the tonB-independent uptake of proteins
H1D28_RS07160	COG1028	Short-chain dehydrogenase reductase Sdr
H1D28_RS07165	COG2814	Major facilitator Superfamily
H1D28_RS07180	COG2223	nitrite transmembrane transporter activity
H1D28_RS07200	COG3842	ATPase activity
H1D28_RS07205	COG0395	ABC-type sugar transport system, permease component
H1D28_RS07210	COG1175	transmembrane transport
H1D28_RS07215	COG1917	Cupin 2, conserved barrel domain protein
H1D28_RS07220	COG1794	racemase activity, acting on amino acids and derivatives
H1D28_RS07225	COG0583	DNA-binding transcription factor activity
H1D28_RS07235	COG1609	Transcriptional regulator
H1D28_RS07240	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H1D28_RS07245	COG2723	6-phospho-beta-galactosidase activity
H1D28_RS07250	COG2186	Transcriptional regulator
H1D28_RS07260	COG1609	Transcriptional regulator
H1D28_RS07275	COG0667	Aldo Keto reductase
H1D28_RS07285	COG0861	Integral membrane protein TerC family
H1D28_RS07320	COG2165	general secretion pathway protein
H1D28_RS07325	COG4795	General secretion pathway protein
H1D28_RS07335	COG4967	type IV pilus modification protein PilV
H1D28_RS07340	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H1D28_RS07345	COG1025	Belongs to the peptidase M16 family
H1D28_RS07350	COG1074	ATP-dependent DNA helicase activity
H1D28_RS07355	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H1D28_RS07365	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H1D28_RS07365	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H1D28_RS07370	COG0860	N-Acetylmuramoyl-L-alanine amidase
H1D28_RS07375	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H1D28_RS07405	COG4656	Part of a membrane complex involved in electron transport
H1D28_RS07410	COG1012	belongs to the aldehyde dehydrogenase family
H1D28_RS07410	COG1454	alcohol dehydrogenase
H1D28_RS07600	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
H1D28_RS07605	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H1D28_RS07610	COG2166	iron-sulfur cluster assembly
H1D28_RS07615	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H1D28_RS07625	COG0583	DNA-binding transcription factor activity
H1D28_RS07630	COG2363	Small membrane protein
H1D28_RS07640	COG1349	DNA-binding transcription factor activity
H1D28_RS07660	COG0738	Major facilitator superfamily
H1D28_RS07665	COG0235	Class ii aldolase
H1D28_RS07670	COG1454	alcohol dehydrogenase
H1D28_RS07690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1D28_RS07705	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H1D28_RS07710	COG2011	ABC-type metal ion transport system permease component
H1D28_RS07715	COG1464	Belongs to the NlpA lipoprotein family
H1D28_RS07720	COG0477	Major facilitator Superfamily
H1D28_RS07730	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1D28_RS07735	COG1760	l-serine dehydratase
H1D28_RS07740	COG0814	amino acid
H1D28_RS07745	COG1611	Belongs to the LOG family
H1D28_RS07760	COG3098	single-species biofilm formation
H1D28_RS07765	COG0564	pseudouridine synthase activity
H1D28_RS07770	COG0716	FMN binding
H1D28_RS07775	COG2271	Major facilitator Superfamily
H1D28_RS07780	COG4948	Mandelate Racemase Muconate Lactonizing
H1D28_RS07785	COG4948	Mandelate Racemase Muconate Lactonizing
H1D28_RS07790	COG1929	Belongs to the glycerate kinase type-1 family
H1D28_RS07795	COG4999	Histidine kinase
H1D28_RS07795	COG3850	Histidine kinase
H1D28_RS07795	COG2205	protein histidine kinase activity
H1D28_RS07795	COG3437	response regulator, receiver
H1D28_RS07805	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H1D28_RS07810	COG3956	TIGRFAM MazG family protein
H1D28_RS07830	COG0602	queuosine metabolic process
H1D28_RS07835	COG0720	synthase
H1D28_RS07855	COG1203	CRISPR-associated helicase, Cas3
H1D28_RS07870	COG1857	crispr-associated protein
H1D28_RS07885	COG1518	maintenance of DNA repeat elements
H1D28_RS07890	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H1D28_RS07905	COG2234	aminopeptidase activity
H1D28_RS07965	COG4942	peptidase
H1D28_RS07965	COG1388	LysM domain
H1D28_RS07970	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H1D28_RS07995	COG0163	prenyltransferase activity
H1D28_RS08000	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H1D28_RS08040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1D28_RS08045	COG4558	Periplasmic binding protein
H1D28_RS08050	COG3720	iron ion transport
H1D28_RS08070	COG0679	Auxin Efflux Carrier
H1D28_RS08085	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H1D28_RS08090	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H1D28_RS08095	COG1121	(ABC) transporter
H1D28_RS08100	COG0803	Belongs to the bacterial solute-binding protein 9 family
H1D28_RS08105	COG1609	Transcriptional regulator
H1D28_RS08110	COG1940	carbohydrate kinase activity
H1D28_RS08115	COG1447	Phosphotransferase system cellobiose-specific component IIA
H1D28_RS08120	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H1D28_RS08125	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H1D28_RS08130	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H1D28_RS08135	COG4580	involved in the transport of maltose and maltodextrins
H1D28_RS08145	COG2723	6-phospho-beta-galactosidase activity
H1D28_RS08155	COG0309	Hydrogenase expression formation protein (HypE)
H1D28_RS08160	COG0409	Hydrogenase expression formation protein
H1D28_RS08165	COG0298	carbon dioxide binding
H1D28_RS08170	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H1D28_RS08185	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H1D28_RS08190	COG0651	ATP synthesis coupled electron transport
H1D28_RS08195	COG0650	Formate hydrogenlyase subunit 4
H1D28_RS08200	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
H1D28_RS08200	COG3261	NADH dehydrogenase
H1D28_RS08205	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H1D28_RS08210	COG3260	NADH ubiquinone oxidoreductase 20
H1D28_RS08220	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
H1D28_RS08230	COG2723	6-phospho-beta-galactosidase activity
H1D28_RS08235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H1D28_RS08235	COG1263	PTS System
H1D28_RS08240	COG1609	Transcriptional regulator
H1D28_RS08245	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H1D28_RS08250	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
H1D28_RS08255	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
H1D28_RS08280	COG1349	DNA-binding transcription factor activity
H1D28_RS08285	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
H1D28_RS08290	COG1028	Short-chain dehydrogenase reductase Sdr
H1D28_RS08300	COG3732	PTS system glucitol sorbitol-specific
H1D28_RS08305	COG3730	PTS system glucitol sorbitol-specific
H1D28_RS08310	COG2951	lytic endotransglycosylase activity
H1D28_RS08315	COG1121	(ABC) transporter
H1D28_RS08320	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H1D28_RS08325	COG0803	Belongs to the bacterial solute-binding protein 9 family
H1D28_RS08330	COG1546	Belongs to the CinA family
H1D28_RS08350	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H1D28_RS08380	COG2823	Periplasmic or secreted lipoprotein
H1D28_RS08385	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H1D28_RS08390	COG1238	metal cluster binding
H1D28_RS08410	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H1D28_RS08415	COG2814	Major facilitator Superfamily
H1D28_RS08420	COG1566	PFAM secretion protein HlyD family protein
H1D28_RS08425	COG1846	Transcriptional regulator
H1D28_RS08435	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H1D28_RS08445	COG4176	ABC-type proline glycine betaine transport system permease component
H1D28_RS08460	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H1D28_RS08470	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H1D28_RS08475	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H1D28_RS08480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1D28_RS08485	COG4575	ribosome binding
H1D28_RS08500	COG2916	Histone family protein nucleoid-structuring protein H-NS
H1D28_RS08515	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H1D28_RS08520	COG0640	Transcriptional regulator
H1D28_RS08530	COG0583	DNA-binding transcription factor activity
H1D28_RS08535	COG3284	Transcriptional regulator
H1D28_RS08540	COG1012	belongs to the aldehyde dehydrogenase family
H1D28_RS08545	COG3539	Fimbrial protein
H1D28_RS08550	COG3121	Chaperone
H1D28_RS08565	COG3121	Chaperone
H1D28_RS08585	COG1028	Short-chain dehydrogenase reductase Sdr
H1D28_RS08595	COG0235	Class ii aldolase
H1D28_RS08600	COG1126	abc transporter atp-binding protein
H1D28_RS08605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1D28_RS08640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1D28_RS08645	COG3708	Transcriptional regulator
H1D28_RS08645	COG2207	Transcriptional regulator
H1D28_RS08675	COG2867	negative regulation of translational initiation
H1D28_RS08690	COG0497	DNA recombination
H1D28_RS08705	COG4536	flavin adenine dinucleotide binding
H1D28_RS08710	COG4137	Cytochrome C assembly protein
H1D28_RS08715	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H1D28_RS08750	COG2885	chlorophyll binding
H1D28_RS08755	COG2199	diguanylate cyclase activity
H1D28_RS08765	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H1D28_RS08770	COG0287	Prephenate dehydrogenase
H1D28_RS08770	COG1605	Chorismate mutase
H1D28_RS08780	COG0077	Prephenate dehydratase
H1D28_RS08780	COG1605	Chorismate mutase
H1D28_RS08790	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H1D28_RS08795	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H1D28_RS08810	COG0542	response to heat
H1D28_RS08835	COG0477	Major facilitator Superfamily
H1D28_RS08840	COG5544	Lipoprotein
H1D28_RS08845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H1D28_RS08860	COG3118	belongs to the thioredoxin family
H1D28_RS08865	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H1D28_RS08880	COG0513	Belongs to the DEAD box helicase family
H1D28_RS08890	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H1D28_RS08905	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
H1D28_RS08910	COG3026	antisigma factor binding
H1D28_RS08915	COG3086	response to oxidative stress
H1D28_RS08925	COG0681	Belongs to the peptidase S26 family
H1D28_RS08945	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H1D28_RS08955	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H1D28_RS08960	COG1737	Transcriptional regulator
H1D28_RS08965	COG0560	Phosphoserine phosphatase
H1D28_RS08980	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H1D28_RS08980	COG0047	phosphoribosylformylglycinamidine synthase activity
H1D28_RS08985	COG2205	protein histidine kinase activity
H1D28_RS08990	COG3170	Tfp pilus assembly protein FimV
H1D28_RS08995	COG2204	response regulator
H1D28_RS09000	COG0347	Belongs to the P(II) protein family
H1D28_RS09005	COG1017	nitric oxide dioxygenase activity
H1D28_RS09005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H1D28_RS09015	COG2259	Doxx family
H1D28_RS09020	COG1940	carbohydrate kinase activity
H1D28_RS09025	COG0457	Tetratricopeptide repeat
H1D28_RS09030	COG2814	Major facilitator Superfamily
H1D28_RS09030	COG0477	Major facilitator Superfamily
H1D28_RS09035	COG2017	converts alpha-aldose to the beta-anomer
H1D28_RS09040	COG2814	Major facilitator Superfamily
H1D28_RS09045	COG3711	transcriptional antiterminator
H1D28_RS09050	COG3683	transport system, periplasmic component
H1D28_RS09055	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
H1D28_RS09085	COG0822	iron-sulfur transferase activity
H1D28_RS09105	COG0633	Ferredoxin
H1D28_RS09110	COG2975	iron-sulfur cluster assembly
H1D28_RS09130	COG2897	thiosulfate sulfurtransferase activity
H1D28_RS09135	COG2373	Large extracellular alpha-helical protein
H1D28_RS09140	COG4953	penicillin-binding protein 1C
H1D28_RS09170	COG2976	Protein conserved in bacteria
H1D28_RS09190	COG1645	bacterial-type flagellum-dependent swarming motility
H1D28_RS09200	COG0516	GMP reductase activity
H1D28_RS09200	COG0517	IMP dehydrogenase activity
H1D28_RS09210	COG3119	arylsulfatase activity
H1D28_RS09215	COG0641	radical SAM
H1D28_RS09235	COG2200	EAL domain
H1D28_RS09250	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H1D28_RS09265	COG2723	6-phospho-beta-galactosidase activity
H1D28_RS09275	COG2233	PERMEase
H1D28_RS09290	COG1393	Belongs to the ArsC family
H1D28_RS09295	COG4783	chaperone-mediated protein folding
H1D28_RS09305	COG0628	permease
H1D28_RS09310	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H1D28_RS09315	COG2716	regulation of RNA biosynthetic process
H1D28_RS09325	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
H1D28_RS09335	COG2321	neutral zinc metallopeptidase
H1D28_RS09340	COG1444	tRNA N-acetyltransferase activity
H1D28_RS09345	COG0400	carboxylic ester hydrolase activity
H1D28_RS09360	COG1393	Belongs to the ArsC family
H1D28_RS09370	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H1D28_RS09375	COG0493	'glutamate synthase
H1D28_RS09375	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H1D28_RS09385	COG5342	invasion associated locus B
H1D28_RS09390	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H1D28_RS09395	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H1D28_RS09405	COG4810	utilization protein
H1D28_RS09495	COG0860	N-Acetylmuramoyl-L-alanine amidase
H1D28_RS09515	COG2837	iron assimilation
H1D28_RS09525	COG4150	thiosulfate binding
H1D28_RS09530	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H1D28_RS09535	COG4208	sulfate ABC transporter
H1D28_RS09540	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H1D28_RS09550	COG4319	ketosteroid isomerase
H1D28_RS09585	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H1D28_RS09605	COG3530	Putative quorum-sensing-regulated virulence factor
H1D28_RS09610	COG0385	Bile acid
H1D28_RS09615	COG0583	DNA-binding transcription factor activity
H1D28_RS09645	COG3415	Transposase
H1D28_RS09650	COG3415	Transposase
H1D28_RS09665	COG2199	diguanylate cyclase activity
H1D28_RS09665	COG2200	EAL domain
H1D28_RS09670	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H1D28_RS09685	COG0667	Aldo Keto reductase
H1D28_RS09690	COG3961	Belongs to the TPP enzyme family
H1D28_RS09705	COG3279	Response regulator of the LytR AlgR family
H1D28_RS09710	COG3275	phosphorelay sensor kinase activity
H1D28_RS09725	COG0436	Aminotransferase
H1D28_RS09735	COG2807	transmembrane transport
H1D28_RS09740	COG0590	tRNA wobble adenosine to inosine editing
H1D28_RS09745	COG0583	DNA-binding transcription factor activity
H1D28_RS09780	COG2814	Major facilitator Superfamily
H1D28_RS09785	COG4221	oxidoreductase activity
H1D28_RS09790	COG2171	N-acyltransferase activity
H1D28_RS09845	COG1122	ATPase activity
H1D28_RS09880	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H1D28_RS09880	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H1D28_RS09885	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H1D28_RS09885	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H1D28_RS09890	COG3715	PTS system
H1D28_RS09895	COG3716	PTS system mannose fructose sorbose family IID component
H1D28_RS09910	COG2376	Dihydroxyacetone kinase
H1D28_RS09915	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
H1D28_RS09920	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H1D28_RS09935	COG2801	Transposase and inactivated derivatives
H1D28_RS09960	COG3121	Chaperone
H1D28_RS09965	COG3188	usher protein
H1D28_RS09985	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H1D28_RS10005	COG2116	formate transmembrane transporter activity
H1D28_RS10010	COG2853	Lipoprotein
H1D28_RS10020	COG3691	Protein conserved in bacteria
H1D28_RS10035	COG2062	phosphohistidine phosphatase, SixA
H1D28_RS10060	COG0730	response to heat
H1D28_RS10065	COG3101	peptidyl-lysine hydroxylation
H1D28_RS10080	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H1D28_RS10100	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H1D28_RS10110	COG0586	Pfam SNARE associated Golgi protein
H1D28_RS10120	COG0285	dihydrofolate synthase activity
H1D28_RS10125	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
H1D28_RS10130	COG1286	toxin biosynthetic process
H1D28_RS10135	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H1D28_RS10140	COG3829	transcription factor binding
H1D28_RS10150	COG0531	amino acid
H1D28_RS10155	COG3457	Alanine racemase
H1D28_RS10160	COG0833	amino acid
H1D28_RS10165	COG0163	prenyltransferase activity
H1D28_RS10190	COG4160	amino acid transport
H1D28_RS10195	COG4598	ABC transporter
H1D28_RS10210	COG1090	epimerase
H1D28_RS10215	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H1D28_RS10220	COG0625	glutathione transferase activity
H1D28_RS10225	COG0625	glutathione transferase activity
H1D28_RS10230	COG0622	Phosphoesterase
H1D28_RS10235	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H1D28_RS10240	COG0857	belongs to the CobB CobQ family
H1D28_RS10240	COG0280	phosphate acetyltransferase
H1D28_RS10260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H1D28_RS10265	COG0471	metal ion transport
H1D28_RS10265	COG0490	domain, Protein
H1D28_RS10275	COG0436	Aminotransferase
H1D28_RS10280	COG0583	DNA-binding transcription factor activity
H1D28_RS10325	COG0839	Belongs to the complex I subunit 6 family
H1D28_RS10335	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H1D28_RS10340	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H1D28_RS10355	COG2153	protein acetylation
H1D28_RS10360	COG1169	isochorismate synthase
H1D28_RS10385	COG0318	PFAM AMP-dependent synthetase and ligase
H1D28_RS10395	COG5464	transposase or invertase
H1D28_RS10410	COG1414	Transcriptional regulator
H1D28_RS10420	COG2271	Major facilitator Superfamily
H1D28_RS10430	COG0247	lactate metabolic process
H1D28_RS10440	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H1D28_RS10445	COG2271	Major facilitator Superfamily
H1D28_RS10450	COG0584	glycerophosphoryl diester phosphodiesterase
H1D28_RS10455	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H1D28_RS10480	COG2205	protein histidine kinase activity
H1D28_RS10480	COG0784	Response regulator, receiver
H1D28_RS10490	COG0642	Histidine kinase
H1D28_RS10490	COG2198	Histidine kinase
H1D28_RS10505	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H1D28_RS10505	COG2169	Transcriptional regulator
H1D28_RS10510	COG3145	DNA-N1-methyladenine dioxygenase activity
H1D28_RS10515	COG4615	Cyclic peptide transporter
H1D28_RS10520	COG2239	Acts as a magnesium transporter
H1D28_RS10525	COG0659	secondary active sulfate transmembrane transporter activity
H1D28_RS10540	COG0628	permease
H1D28_RS10565	COG1349	DNA-binding transcription factor activity
H1D28_RS10570	COG0494	nUDIX hydrolase
H1D28_RS10590	COG1061	Type III restriction enzyme res subunit
H1D28_RS10595	COG1187	pseudouridine synthase activity
H1D28_RS10600	COG2814	Major facilitator Superfamily
H1D28_RS10610	COG4172	Belongs to the ABC transporter superfamily
H1D28_RS10615	COG4239	(ABC) transporter, permease
H1D28_RS10620	COG4174	ABC transporter (Permease)
H1D28_RS10625	COG4166	transmembrane transport
H1D28_RS10630	COG2200	EAL domain
H1D28_RS10635	COG0791	NLP P60 protein
H1D28_RS10640	COG0671	phosphoesterase, PA-phosphatase related
H1D28_RS10645	COG0523	cobalamin synthesis protein
H1D28_RS10650	COG0246	Mannitol dehydrogenase
H1D28_RS10655	COG1312	Catalyzes the dehydration of D-mannonate
H1D28_RS10680	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H1D28_RS10680	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H1D28_RS10685	COG1105	Belongs to the carbohydrate kinase PfkB family
H1D28_RS10690	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H1D28_RS10690	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H1D28_RS10690	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H1D28_RS10700	COG2855	membrane
H1D28_RS10705	COG0583	DNA-binding transcription factor activity
H1D28_RS10710	COG0833	amino acid
H1D28_RS10715	COG4771	TonB-dependent receptor
H1D28_RS10730	COG2311	Membrane
H1D28_RS10745	COG1129	ABC transporter
H1D28_RS10755	COG2949	membrane
H1D28_RS10765	COG1346	cytolysis
H1D28_RS10775	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H1D28_RS10780	COG3659	wide pore channel activity
H1D28_RS10795	COG2723	6-phospho-beta-galactosidase activity
H1D28_RS10800	COG1538	Outer membrane efflux protein
H1D28_RS10805	COG0586	Pfam SNARE associated Golgi protein
H1D28_RS10815	COG1686	Belongs to the peptidase S11 family
H1D28_RS10825	COG0277	FAD linked oxidase domain protein
H1D28_RS10830	COG1472	Belongs to the glycosyl hydrolase 3 family
H1D28_RS10835	COG1732	Glycine betaine
H1D28_RS10840	COG1174	glycine betaine transport
H1D28_RS10845	COG1125	glycine betaine transport
H1D28_RS10850	COG1174	glycine betaine transport
H1D28_RS10860	COG3275	phosphorelay sensor kinase activity
H1D28_RS10870	COG4807	Protein conserved in bacteria
H1D28_RS10890	COG5455	response to cobalt ion
H1D28_RS10895	COG0583	DNA-binding transcription factor activity
H1D28_RS10900	COG2252	PERMEase
H1D28_RS10910	COG0583	DNA-binding transcription factor activity
H1D28_RS10925	COG0351	phosphomethylpyrimidine kinase
H1D28_RS10930	COG1830	Aldolase
H1D28_RS10975	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H1D28_RS10980	COG4948	Mandelate Racemase Muconate Lactonizing
H1D28_RS10985	COG0747	negative chemotaxis
H1D28_RS10990	COG0601	transmembrane transport
H1D28_RS11000	COG0444	Belongs to the ABC transporter superfamily
H1D28_RS11005	COG4608	Belongs to the ABC transporter superfamily
H1D28_RS11020	COG0745	RESPONSE REGULATOR receiver
H1D28_RS11025	COG2205	protein histidine kinase activity
H1D28_RS11050	COG1301	dicarboxylic acid transport
H1D28_RS11070	COG5002	protein histidine kinase activity
H1D28_RS11075	COG0443	Heat shock 70 kDa protein
H1D28_RS11080	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H1D28_RS11095	COG2982	Protein involved in outer membrane biogenesis
H1D28_RS11100	COG1253	flavin adenine dinucleotide binding
H1D28_RS11155	COG1442	glycosyl transferase family 8
H1D28_RS11155	COG1216	Glycosyl transferase, family 2
H1D28_RS11165	COG0438	transferase activity, transferring glycosyl groups
H1D28_RS11200	COG1088	dTDP-glucose 4,6-dehydratase activity
H1D28_RS11270	COG0438	transferase activity, transferring glycosyl groups
H1D28_RS11275	COG1215	transferase activity, transferring glycosyl groups
H1D28_RS11295	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H1D28_RS11325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H1D28_RS11330	COG0583	DNA-binding transcription factor activity
H1D28_RS11340	COG0531	amino acid
H1D28_RS11345	COG0640	Transcriptional regulator
H1D28_RS11350	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H1D28_RS11355	COG2925	Exonuclease
H1D28_RS11370	COG1289	transmembrane transporter activity
H1D28_RS11390	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H1D28_RS11400	COG1942	4-Oxalocrotonate Tautomerase
H1D28_RS11405	COG0583	DNA-binding transcription factor activity
H1D28_RS11410	COG0095	Lipoate-protein ligase
H1D28_RS11415	COG0477	Major facilitator Superfamily
H1D28_RS11425	COG3300	MHYT domain
H1D28_RS11425	COG5001	Diguanylate cyclase
H1D28_RS11435	COG3615	Tellurite resistance protein tehB
H1D28_RS11460	COG3706	GGDEF domain
H1D28_RS11480	COG0534	Mate efflux family protein
H1D28_RS11490	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H1D28_RS11510	COG0604	alcohol dehydrogenase
H1D28_RS11515	COG1309	transcriptional regulator
H1D28_RS11520	COG0025	NhaP-type Na H and K H
H1D28_RS11635	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
H1D28_RS11640	COG1403	HNH endonuclease
H1D28_RS11660	COG3772	lysozyme
H1D28_RS11695	COG4626	Terminase
H1D28_RS11695	COG1802	Transcriptional regulator
H1D28_RS11700	COG4695	Portal protein
H1D28_RS11705	COG0740	serine-type endopeptidase activity
H1D28_RS11755	COG1484	DNA-dependent DNA replication
H1D28_RS11760	COG4584	PFAM Integrase catalytic
H1D28_RS11810	COG3344	reverse transcriptase
H1D28_RS11820	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H1D28_RS11830	COG1418	mRNA catabolic process
H1D28_RS11835	COG0270	DNA (cytosine-5-)-methyltransferase activity
H1D28_RS11840	COG3727	T/G mismatch-specific endonuclease activity
H1D28_RS11845	COG0697	spore germination
H1D28_RS11850	COG2354	Protein conserved in bacteria
H1D28_RS11880	COG0366	Alpha amylase catalytic
H1D28_RS11905	COG2197	response regulator
H1D28_RS11915	COG2197	response regulator
H1D28_RS11950	COG3012	SEC-C Motif Domain Protein
H1D28_RS11950	COG3318	Belongs to the UPF0149 family
H1D28_RS11955	COG0814	amino acid
H1D28_RS11965	COG1528	Iron-storage protein
H1D28_RS11980	COG0477	Major facilitator Superfamily
H1D28_RS11990	COG2211	Major facilitator Superfamily
H1D28_RS12000	COG1528	Iron-storage protein
H1D28_RS12010	COG1879	ABC-type sugar transport system periplasmic component
H1D28_RS12020	COG1172	Belongs to the binding-protein-dependent transport system permease family
H1D28_RS12045	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
H1D28_RS12055	COG3102	Protein conserved in bacteria
H1D28_RS12075	COG3788	relative of glutathione S-transferase, MAPEG superfamily
H1D28_RS12080	COG1801	Protein of unknown function DUF72
H1D28_RS12085	COG1335	isochorismatase
H1D28_RS12095	COG0494	nUDIX hydrolase
H1D28_RS12120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H1D28_RS12130	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
H1D28_RS12135	COG0739	heme binding
H1D28_RS12140	COG1560	Kdo2-lipid A biosynthetic process
H1D28_RS12150	COG1737	Transcriptional regulator
H1D28_RS12160	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H1D28_RS12165	COG0129	dihydroxy-acid dehydratase activity
H1D28_RS12170	COG0800	Aldolase
H1D28_RS12180	COG3141	response to X-ray
H1D28_RS12185	COG2979	Protein of unknown function (DUF533)
H1D28_RS12190	COG1770	oligopeptidase
H1D28_RS12195	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H1D28_RS12205	COG2372	response to copper ion
H1D28_RS12210	COG1276	copper resistance
H1D28_RS12225	COG2990	Protein conserved in bacteria
H1D28_RS12250	COG3008	intermembrane lipid transfer
H1D28_RS12255	COG2995	paraquat-inducible protein a
H1D28_RS12260	COG1956	GAF domain-containing protein
H1D28_RS12280	COG2814	Major facilitator Superfamily
H1D28_RS12285	COG1414	Transcriptional regulator
H1D28_RS12315	COG0768	penicillin binding
H1D28_RS12320	COG2226	methyltransferase
H1D28_RS12335	COG3716	PTS system mannose fructose sorbose family IID component
H1D28_RS12340	COG3715	PTS system
H1D28_RS12345	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H1D28_RS12345	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H1D28_RS12350	COG1253	flavin adenine dinucleotide binding
H1D28_RS12355	COG2200	EAL domain
H1D28_RS12360	COG1760	l-serine dehydratase
H1D28_RS12380	COG0251	oxidation-reduction process
H1D28_RS12385	COG1199	ATP-dependent helicase activity
H1D28_RS12395	COG3065	identical protein binding
H1D28_RS12405	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H1D28_RS12415	COG2894	cell division
H1D28_RS12430	COG0179	Fumarylacetoacetate (FAA) hydrolase
H1D28_RS12460	COG2719	SpoVR family
H1D28_RS12485	COG1619	proteins homologs of microcin C7 resistance protein MccF
H1D28_RS12495	COG4774	siderophore transport
H1D28_RS12510	COG2308	Evidence 4 Homologs of previously reported genes of
H1D28_RS12550	COG0583	DNA-binding transcription factor activity
H1D28_RS12555	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H1D28_RS12570	COG1882	Formate acetyltransferase
H1D28_RS12605	COG0583	DNA-binding transcription factor activity
H1D28_RS12635	COG0583	DNA-binding transcription factor activity
H1D28_RS12650	COG3122	Protein conserved in bacteria
H1D28_RS12670	COG2885	chlorophyll binding
H1D28_RS12680	COG3501	Rhs element vgr protein
H1D28_RS12735	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H1D28_RS12825	COG0012	GTP binding
H1D28_RS12845	COG0659	secondary active sulfate transmembrane transporter activity
H1D28_RS12875	COG2890	protein-(glutamine-N5) methyltransferase activity
H1D28_RS12895	COG0387	Pfam Sodium calcium exchanger
H1D28_RS12900	COG4572	Cation transport regulator
H1D28_RS12905	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
H1D28_RS12915	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H1D28_RS12920	COG3707	response regulator
H1D28_RS12925	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1D28_RS12935	COG1116	anion transmembrane transporter activity
H1D28_RS12940	COG2146	nitrite reductase [NAD(P)H] activity
H1D28_RS12940	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H1D28_RS12945	COG0243	molybdopterin cofactor binding
H1D28_RS12950	COG4932	domain protein
H1D28_RS12955	COG2197	response regulator
H1D28_RS12960	COG3850	Histidine kinase
H1D28_RS12965	COG2223	nitrite transmembrane transporter activity
H1D28_RS12975	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
H1D28_RS12980	COG1140	nitrate reductase beta subunit
H1D28_RS12985	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
H1D28_RS12990	COG2181	nitrate reductase activity
H1D28_RS13000	COG1522	sequence-specific DNA binding
H1D28_RS13030	COG0788	formyltetrahydrofolate deformylase activity
H1D28_RS13040	COG1752	Esterase of the alpha-beta hydrolase superfamily
H1D28_RS13045	COG0745	RESPONSE REGULATOR receiver
H1D28_RS13050	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H1D28_RS13055	COG2916	Histone family protein nucleoid-structuring protein H-NS
H1D28_RS13065	COG1435	thymidine kinase activity
H1D28_RS13070	COG1454	alcohol dehydrogenase
H1D28_RS13070	COG1012	belongs to the aldehyde dehydrogenase family
H1D28_RS13080	COG2095	MarC family integral membrane protein
H1D28_RS13085	COG4166	transmembrane transport
H1D28_RS13090	COG0601	transmembrane transport
H1D28_RS13095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1D28_RS13100	COG0444	Belongs to the ABC transporter superfamily
H1D28_RS13110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H1D28_RS13130	COG2353	YceI-like domain
H1D28_RS13140	COG2350	Protein conserved in bacteria
H1D28_RS13150	COG3001	Fructosamine kinase
H1D28_RS13160	COG1105	Belongs to the carbohydrate kinase PfkB family
H1D28_RS13165	COG3137	Salt-induced outer membrane protein
H1D28_RS13205	COG0072	phenylalanine-tRNA ligase activity
H1D28_RS13205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H1D28_RS13225	COG0583	DNA-binding transcription factor activity
H1D28_RS13245	COG0386	Belongs to the glutathione peroxidase family
H1D28_RS13255	COG0791	NLP P60 protein
H1D28_RS13265	COG4256	Hemin uptake protein
H1D28_RS13270	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H1D28_RS13285	COG0574	Belongs to the PEP-utilizing enzyme family
H1D28_RS13285	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H1D28_RS13295	COG0628	permease
H1D28_RS13300	COG0247	lactate metabolic process
H1D28_RS13300	COG0277	FAD linked oxidase domain protein
H1D28_RS13305	COG2050	protein possibly involved in aromatic compounds catabolism
H1D28_RS13310	COG2261	transglycosylase associated protein
H1D28_RS13335	COG1120	ATPase activity
H1D28_RS13340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1D28_RS13350	COG0583	DNA-binding transcription factor activity
H1D28_RS13375	COG1304	FMN binding
H1D28_RS13385	COG0316	Belongs to the HesB IscA family
H1D28_RS13390	COG0719	Fe-S assembly protein
H1D28_RS13395	COG0396	ATPase activity
H1D28_RS13400	COG0719	Fe-S assembly protein
H1D28_RS13415	COG1376	ErfK ybiS ycfS ynhG family protein
H1D28_RS13445	COG1309	transcriptional regulator
H1D28_RS13455	COG2271	Major facilitator Superfamily
H1D28_RS13460	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H1D28_RS13485	COG1414	Transcriptional regulator
H1D28_RS13520	COG2814	Major facilitator Superfamily
H1D28_RS13540	COG0583	DNA-binding transcription factor activity
H1D28_RS13545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1D28_RS13565	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1D28_RS13570	COG1116	anion transmembrane transporter activity
H1D28_RS13575	COG4774	siderophore transport
H1D28_RS13580	COG1120	ATPase activity
H1D28_RS13585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1D28_RS13590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1D28_RS13610	COG0765	amino acid transport
H1D28_RS13615	COG1126	abc transporter atp-binding protein
H1D28_RS13655	COG3383	formate dehydrogenase (NAD+) activity
H1D28_RS13660	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
H1D28_RS13670	COG1175	transmembrane transport
H1D28_RS13700	COG4133	protoheme IX ABC transporter activity
H1D28_RS13705	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H1D28_RS13710	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H1D28_RS13725	COG1138	Cytochrome C-type biogenesis protein
H1D28_RS13730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H1D28_RS13735	COG3088	subunit of a heme lyase
H1D28_RS13735	COG4235	cytochrome complex assembly
H1D28_RS13755	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
H1D28_RS13770	COG5002	protein histidine kinase activity
H1D28_RS13770	COG3850	Histidine kinase
H1D28_RS13775	COG0745	RESPONSE REGULATOR receiver
H1D28_RS13790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H1D28_RS13820	COG1028	Short-chain dehydrogenase reductase Sdr
H1D28_RS13825	COG2610	gluconate transmembrane transporter activity
H1D28_RS13830	COG1250	3-hydroxyacyl-CoA dehydrogenase
H1D28_RS13840	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H1D28_RS13850	COG0583	DNA-binding transcription factor activity
H1D28_RS13880	COG2814	Major facilitator Superfamily
H1D28_RS13895	COG0277	FAD linked oxidase domain protein
H1D28_RS13900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1D28_RS13925	COG0402	S-adenosylhomocysteine deaminase activity
H1D28_RS13965	COG1028	Short-chain dehydrogenase reductase Sdr
H1D28_RS13965	COG3321	synthase
H1D28_RS13965	COG0604	alcohol dehydrogenase
H1D28_RS13995	COG4608	Belongs to the ABC transporter superfamily
H1D28_RS14000	COG0444	Belongs to the ABC transporter superfamily
H1D28_RS14025	COG0346	lactoylglutathione lyase activity
H1D28_RS14030	COG1349	DNA-binding transcription factor activity
H1D28_RS14065	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H1D28_RS14115	COG0307	riboflavin synthase, alpha
H1D28_RS14120	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H1D28_RS14125	COG2814	Major facilitator Superfamily
H1D28_RS14130	COG0583	DNA-binding transcription factor activity
H1D28_RS14145	COG2814	Major facilitator Superfamily
H1D28_RS14165	COG0582	viral genome integration into host DNA
H1D28_RS14240	COG0791	NLP P60 protein
H1D28_RS14245	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H1D28_RS14255	COG0346	lactoylglutathione lyase activity
H1D28_RS14260	COG1902	pentaerythritol trinitrate reductase activity
H1D28_RS14265	COG1309	transcriptional regulator
H1D28_RS14270	COG3313	Fe-S protein
H1D28_RS14275	COG4989	oxidoreductase activity
H1D28_RS14280	COG2032	superoxide dismutase activity
H1D28_RS14285	COG1289	transmembrane transporter activity
H1D28_RS14290	COG1566	PFAM secretion protein HlyD family protein
H1D28_RS14305	COG3706	GGDEF domain
H1D28_RS14320	COG3895	Periplasmic Protein
H1D28_RS14335	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H1D28_RS14340	COG0625	glutathione transferase activity
H1D28_RS14350	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H1D28_RS14360	COG4659	FMN binding
H1D28_RS14395	COG2723	6-phospho-beta-galactosidase activity
H1D28_RS14405	COG0673	inositol 2-dehydrogenase activity
H1D28_RS14415	COG2814	Major facilitator Superfamily
H1D28_RS14435	COG3038	cytochrome b561
H1D28_RS14455	COG0583	DNA-binding transcription factor activity
H1D28_RS14460	COG3485	protocatechuate 3,4-dioxygenase
H1D28_RS14465	COG3485	protocatechuate 3,4-dioxygenase
H1D28_RS14470	COG5383	Protein conserved in bacteria
H1D28_RS14475	COG2272	Belongs to the type-B carboxylesterase lipase family
H1D28_RS14490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H1D28_RS14495	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H1D28_RS14500	COG1275	C4-dicarboxylate transporter malic acid transport protein
H1D28_RS14505	COG0500	methyltransferase
H1D28_RS14515	COG0697	spore germination
H1D28_RS14520	COG3708	Transcriptional regulator
H1D28_RS14520	COG2207	Transcriptional regulator
H1D28_RS14525	COG3135	benzoate transporter
H1D28_RS14530	COG1396	sequence-specific DNA binding
H1D28_RS14540	COG0826	peptidase U32
H1D28_RS14560	COG1294	oxidase, subunit
H1D28_RS14565	COG1271	oxidase subunit
H1D28_RS14570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1D28_RS14575	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H1D28_RS14580	COG3842	ATPase activity
H1D28_RS14585	COG1176	ABC-type spermidine putrescine transport system, permease component I
H1D28_RS14590	COG1177	transmembrane transport
H1D28_RS14595	COG1012	belongs to the aldehyde dehydrogenase family
H1D28_RS14630	COG1012	belongs to the aldehyde dehydrogenase family
H1D28_RS14635	COG0747	negative chemotaxis
H1D28_RS14645	COG3238	Protein conserved in bacteria
H1D28_RS14650	COG1247	-acetyltransferase
H1D28_RS14660	COG2130	NADP-dependent
H1D28_RS14675	COG3691	Protein conserved in bacteria
H1D28_RS14680	COG1228	amidohydrolase
H1D28_RS14685	COG4772	TonB-dependent receptor
H1D28_RS14710	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H1D28_RS14715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1D28_RS14720	COG1473	amidohydrolase
H1D28_RS14725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1D28_RS14740	COG0765	amino acid transport
H1D28_RS14745	COG1126	abc transporter atp-binding protein
H1D28_RS14755	COG0625	glutathione transferase activity
H1D28_RS14775	COG2211	Major facilitator Superfamily
H1D28_RS14790	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1D28_RS14795	COG3842	ATPase activity
H1D28_RS14800	COG1840	ABC-type Fe3 transport system, periplasmic component
H1D28_RS14805	COG1178	ABC-type Fe3 transport system permease component
H1D28_RS14810	COG2162	N-hydroxyarylamine O-acetyltransferase activity
H1D28_RS14815	COG2181	nitrate reductase activity
H1D28_RS14820	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
H1D28_RS14825	COG1140	nitrate reductase beta subunit
H1D28_RS14830	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
H1D28_RS14850	COG1414	Transcriptional regulator
H1D28_RS14855	COG4948	Mandelate Racemase Muconate Lactonizing
H1D28_RS14860	COG4829	muconolactone delta-isomerase
H1D28_RS14865	COG3485	protocatechuate 3,4-dioxygenase
H1D28_RS14900	COG0437	4 iron, 4 sulfur cluster binding
H1D28_RS14905	COG2864	formate dehydrogenase
H1D28_RS14920	COG2326	polyphosphate kinase activity
H1D28_RS14930	COG2814	Major facilitator Superfamily
H1D28_RS14940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1D28_RS14960	COG0747	negative chemotaxis
H1D28_RS14965	COG1064	alcohol dehydrogenase
H1D28_RS14980	COG0488	(ABC) transporter
H1D28_RS15025	COG1028	Short-chain dehydrogenase reductase Sdr
H1D28_RS15030	COG3729	General stress protein
H1D28_RS15040	COG3685	Protein conserved in bacteria
H1D28_RS15050	COG0366	Alpha amylase catalytic
H1D28_RS15060	COG2323	membrane
H1D28_RS15070	COG3111	PFAM Bacterial OB fold (BOF) protein
H1D28_RS15080	COG1764	response to oxidative stress
H1D28_RS15105	COG3781	membrane
H1D28_RS15110	COG0243	molybdopterin cofactor binding
H1D28_RS15115	COG0583	DNA-binding transcription factor activity
H1D28_RS15120	COG1447	Phosphotransferase system cellobiose-specific component IIA
H1D28_RS15125	COG2814	Major facilitator Superfamily
H1D28_RS15130	COG1285	pathogenesis
H1D28_RS15135	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H1D28_RS15145	COG0583	DNA-binding transcription factor activity
H1D28_RS15165	COG0519	Catalyzes the synthesis of GMP from XMP
H1D28_RS15165	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H1D28_RS15205	COG0596	Alpha beta hydrolase
H1D28_RS15210	COG0745	RESPONSE REGULATOR receiver
H1D28_RS15215	COG2205	protein histidine kinase activity
H1D28_RS15230	COG0076	glutamate decarboxylase activity
H1D28_RS15235	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H1D28_RS15240	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1D28_RS15245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1D28_RS15250	COG1116	anion transmembrane transporter activity
H1D28_RS15255	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H1D28_RS15270	COG0673	inositol 2-dehydrogenase activity
H1D28_RS15285	COG3706	GGDEF domain
H1D28_RS15290	COG0402	S-adenosylhomocysteine deaminase activity
H1D28_RS15295	COG1953	Uracil, thiamine, allantoin
H1D28_RS15335	COG0406	alpha-ribazole phosphatase activity
H1D28_RS15340	COG1335	isochorismatase
H1D28_RS15355	COG2207	Transcriptional regulator
H1D28_RS15370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H1D28_RS15395	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H1D28_RS15450	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H1D28_RS15460	COG2070	2-Nitropropane dioxygenase
H1D28_RS15465	COG0583	DNA-binding transcription factor activity
H1D28_RS15475	COG1902	pentaerythritol trinitrate reductase activity
H1D28_RS15480	COG4529	Protein conserved in bacteria
H1D28_RS15485	COG0477	Major facilitator Superfamily
H1D28_RS15530	COG2223	nitrite transmembrane transporter activity
H1D28_RS15540	COG1609	Transcriptional regulator
H1D28_RS15545	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H1D28_RS15555	COG3037	sugar-specific permease SgaT UlaA
H1D28_RS15560	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H1D28_RS15570	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H1D28_RS15575	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H1D28_RS15575	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H1D28_RS15575	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H1D28_RS15585	COG1652	LysM domain
H1D28_RS15610	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H1D28_RS15610	COG0456	acetyltransferase
H1D28_RS15620	COG0667	Aldo Keto reductase
H1D28_RS15625	COG0667	Aldo Keto reductase
H1D28_RS15630	COG3386	PFAM SMP-30 Gluconolaconase
H1D28_RS15635	COG0667	Aldo Keto reductase
H1D28_RS15665	COG4977	sequence-specific DNA binding
H1D28_RS15685	COG4977	sequence-specific DNA binding
H1D28_RS15690	COG1349	DNA-binding transcription factor activity
H1D28_RS15705	COG1349	DNA-binding transcription factor activity
H1D28_RS15710	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H1D28_RS15715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H1D28_RS15720	COG0738	Major facilitator superfamily
H1D28_RS15765	COG1929	Belongs to the glycerate kinase type-1 family
H1D28_RS15770	COG3835	regulator
H1D28_RS15790	COG2186	Transcriptional regulator
H1D28_RS15795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H1D28_RS15795	COG1263	PTS System
H1D28_RS15805	COG2814	Major facilitator Superfamily
H1D28_RS15810	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H1D28_RS15810	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H1D28_RS15825	COG2819	hydrolase of the alpha beta superfamily
H1D28_RS15830	COG5001	Diguanylate cyclase
H1D28_RS15830	COG3300	MHYT domain
H1D28_RS15865	COG3188	usher protein
H1D28_RS15880	COG3550	peptidyl-serine autophosphorylation
H1D28_RS15885	COG1396	sequence-specific DNA binding
H1D28_RS15890	COG2351	hydroxyisourate hydrolase activity
H1D28_RS15895	COG3648	Uricase
H1D28_RS15895	COG3195	allantoin biosynthetic process
H1D28_RS15900	COG2233	PERMEase
H1D28_RS15930	COG2207	Transcriptional regulator
H1D28_RS15945	COG4628	conserved protein (DUF2132)
H1D28_RS15965	COG2011	ABC-type metal ion transport system permease component
H1D28_RS15970	COG2070	2-Nitropropane dioxygenase
H1D28_RS15980	COG0477	Major facilitator Superfamily
H1D28_RS16045	COG2199	diguanylate cyclase activity
H1D28_RS16060	COG1012	belongs to the aldehyde dehydrogenase family
H1D28_RS16065	COG0583	DNA-binding transcription factor activity
H1D28_RS16075	COG0039	L-malate dehydrogenase activity
H1D28_RS16080	COG1349	DNA-binding transcription factor activity
H1D28_RS16085	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H1D28_RS16090	COG3395	kinase activity
H1D28_RS16100	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1D28_RS16105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H1D28_RS16110	COG2271	Major facilitator Superfamily
H1D28_RS16135	COG4977	sequence-specific DNA binding
H1D28_RS16150	COG2814	Major facilitator Superfamily
H1D28_RS16185	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H1D28_RS16225	COG2223	nitrite transmembrane transporter activity
H1D28_RS16230	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H1D28_RS16245	COG1349	DNA-binding transcription factor activity
H1D28_RS16250	COG2084	Dehydrogenase
H1D28_RS16255	COG3395	kinase activity
H1D28_RS16260	COG0235	Class ii aldolase
H1D28_RS16265	COG3622	Belongs to the hyi family
H1D28_RS16270	COG2610	gluconate transmembrane transporter activity
H1D28_RS16275	COG3708	Transcriptional regulator
H1D28_RS16275	COG2207	Transcriptional regulator
H1D28_RS16290	COG2200	EAL domain
H1D28_RS16295	COG1546	Belongs to the CinA family
H1D28_RS16300	COG0071	Belongs to the small heat shock protein (HSP20) family
H1D28_RS16315	COG2197	response regulator
H1D28_RS16330	COG2135	peptidase activity
H1D28_RS16335	COG2207	Transcriptional regulator
H1D28_RS16350	COG4221	oxidoreductase activity
H1D28_RS16355	COG1802	Transcriptional regulator
H1D28_RS16360	COG0589	response to stress
H1D28_RS16365	COG0246	Mannitol dehydrogenase
H1D28_RS16370	COG2271	Major facilitator Superfamily
H1D28_RS16385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H1D28_RS16400	COG0243	molybdopterin cofactor binding
H1D28_RS16405	COG0437	4 iron, 4 sulfur cluster binding
H1D28_RS16410	COG3302	dmso reductase anchor subunit
H1D28_RS16425	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H1D28_RS16430	COG1940	carbohydrate kinase activity
H1D28_RS16435	COG0583	DNA-binding transcription factor activity
H1D28_RS16440	COG2814	Major facilitator Superfamily
H1D28_RS16445	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H1D28_RS16455	COG3591	Belongs to the peptidase S1B family
H1D28_RS16475	COG0628	permease
H1D28_RS16505	COG0679	Auxin Efflux Carrier
H1D28_RS16515	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H1D28_RS16550	COG3290	protein histidine kinase activity
H1D28_RS16555	COG4565	transcriptional regulatory protein
H1D28_RS16575	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H1D28_RS16575	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H1D28_RS16585	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H1D28_RS16590	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H1D28_RS16600	COG0183	Belongs to the thiolase family
H1D28_RS16605	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H1D28_RS16615	COG1414	Transcriptional regulator
H1D28_RS16620	COG2840	Smr protein MutS2
H1D28_RS16625	COG0583	DNA-binding transcription factor activity
H1D28_RS16635	COG1473	amidohydrolase
H1D28_RS16640	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
H1D28_RS16655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H1D28_RS16670	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H1D28_RS16675	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H1D28_RS16690	COG0531	amino acid
H1D28_RS16700	COG3136	membrane protein required for alginate biosynthesis
H1D28_RS16705	COG0745	RESPONSE REGULATOR receiver
H1D28_RS16715	COG2205	protein histidine kinase activity
H1D28_RS16725	COG0114	fumarate hydratase activity
H1D28_RS16730	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H1D28_RS16730	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H1D28_RS16735	COG1482	cell wall glycoprotein biosynthetic process
H1D28_RS16740	COG5339	Protein conserved in bacteria
H1D28_RS16745	COG1609	Transcriptional regulator
H1D28_RS16750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H1D28_RS16750	COG1263	PTS System
H1D28_RS16755	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H1D28_RS16780	COG2391	methyltransferase activity
H1D28_RS16785	COG0425	Belongs to the sulfur carrier protein TusA family
H1D28_RS16790	COG5562	phage envelope protein
H1D28_RS16795	COG0401	homolog of Blt101
H1D28_RS16800	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H1D28_RS16805	COG1012	belongs to the aldehyde dehydrogenase family
H1D28_RS16815	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H1D28_RS16820	COG0477	Major facilitator Superfamily
H1D28_RS16825	COG1113	amino acid transport
H1D28_RS16830	COG2988	succinylglutamate desuccinylase activity
H1D28_RS16835	COG3724	N-succinylarginine dihydrolase activity
H1D28_RS16840	COG1012	belongs to the aldehyde dehydrogenase family
H1D28_RS16845	COG3138	arginine N-succinyltransferase
H1D28_RS16850	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H1D28_RS16860	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H1D28_RS16865	COG0667	Aldo Keto reductase
H1D28_RS16870	COG0583	DNA-binding transcription factor activity
H1D28_RS16895	COG4122	O-methyltransferase activity
H1D28_RS16900	COG1643	Atp-dependent helicase
H1D28_RS16915	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H1D28_RS16920	COG3327	negative regulation of DNA-templated transcription, initiation
H1D28_RS16925	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
H1D28_RS16930	COG0183	Belongs to the thiolase family
H1D28_RS16935	COG2050	protein possibly involved in aromatic compounds catabolism
H1D28_RS16940	COG1250	3-hydroxyacyl-CoA dehydrogenase
H1D28_RS16945	COG1024	Enoyl-CoA hydratase
H1D28_RS16950	COG1024	Enoyl-CoA hydratase
H1D28_RS16955	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H1D28_RS16960	COG2151	metal-sulfur cluster biosynthetic enzyme
H1D28_RS16965	COG3396	Phenylacetate-CoA oxygenase
H1D28_RS16970	COG3460	Phenylacetate-CoA oxygenase
H1D28_RS16975	COG3396	Phenylacetate-CoA oxygenase
H1D28_RS16980	COG1012	belongs to the aldehyde dehydrogenase family
H1D28_RS16980	COG2030	dehydratase
H1D28_RS17000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H1D28_RS17015	COG2072	flavoprotein involved in K transport
H1D28_RS17020	COG0583	DNA-binding transcription factor activity
H1D28_RS17025	COG1126	abc transporter atp-binding protein
H1D28_RS17035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1D28_RS17050	COG1012	belongs to the aldehyde dehydrogenase family
H1D28_RS17055	COG2207	Transcriptional regulator
H1D28_RS17060	COG3784	Protein of unknown function (DUF1318)
H1D28_RS17070	COG2911	Protein conserved in bacteria
H1D28_RS17075	COG0586	Pfam SNARE associated Golgi protein
H1D28_RS17080	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H1D28_RS17085	COG3187	Heat shock protein
H1D28_RS17090	COG3042	response to heat
H1D28_RS17095	COG1013	pyruvate-flavodoxin oxidoreductase activity
H1D28_RS17095	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H1D28_RS17095	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H1D28_RS17095	COG0674	pyruvate-flavodoxin oxidoreductase activity
H1D28_RS17100	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H1D28_RS17110	COG0589	response to stress
H1D28_RS17120	COG0513	Belongs to the DEAD box helicase family
H1D28_RS17130	COG1349	DNA-binding transcription factor activity
H1D28_RS17135	COG0673	inositol 2-dehydrogenase activity
H1D28_RS17150	COG1113	amino acid transport
H1D28_RS17155	COG1522	sequence-specific DNA binding
H1D28_RS17165	COG1448	Aminotransferase
H1D28_RS17170	COG2011	ABC-type metal ion transport system permease component
H1D28_RS17185	COG0436	Aminotransferase
H1D28_RS17190	COG0604	alcohol dehydrogenase
H1D28_RS17220	COG0583	DNA-binding transcription factor activity
H1D28_RS17240	COG1028	Short-chain dehydrogenase reductase Sdr
H1D28_RS17245	COG1309	transcriptional regulator
H1D28_RS17250	COG1028	Short-chain dehydrogenase reductase Sdr
H1D28_RS17335	COG2885	chlorophyll binding
H1D28_RS17360	COG0693	protein deglycase activity
H1D28_RS17365	COG1078	dGTPase activity
H1D28_RS17370	COG1028	Short-chain dehydrogenase reductase Sdr
H1D28_RS17375	COG0583	DNA-binding transcription factor activity
H1D28_RS17395	COG0656	L-ascorbic acid biosynthetic process
H1D28_RS17425	COG4166	transmembrane transport
H1D28_RS17435	COG2866	Carboxypeptidase
H1D28_RS17440	COG4948	Mandelate Racemase Muconate Lactonizing
H1D28_RS17445	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
H1D28_RS17450	COG3180	Ammonia monooxygenase
H1D28_RS17460	COG1486	melibiose metabolic process
H1D28_RS17465	COG0583	DNA-binding transcription factor activity
H1D28_RS17475	COG3106	COG3106 Predicted ATPase
H1D28_RS17485	COG1983	PspC domain protein
H1D28_RS17495	COG1842	Phage shock protein A
H1D28_RS17500	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H1D28_RS17510	COG1473	amidohydrolase
H1D28_RS17525	COG0702	epimerase
H1D28_RS17540	COG4171	peptide transport system, permease
H1D28_RS17555	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H1D28_RS17565	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H1D28_RS17570	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H1D28_RS17570	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H1D28_RS17585	COG1349	DNA-binding transcription factor activity
H1D28_RS17595	COG0023	Translation Initiation Factor
H1D28_RS17605	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H1D28_RS17610	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
H1D28_RS17615	COG0671	phosphoesterase, PA-phosphatase related
H1D28_RS17625	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H1D28_RS17650	COG0616	signal peptide processing
H1D28_RS17660	COG1028	Short-chain dehydrogenase reductase Sdr
H1D28_RS17665	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
H1D28_RS17685	COG0653	protein targeting
H1D28_RS17695	COG0583	DNA-binding transcription factor activity
H1D28_RS17705	COG0009	L-threonylcarbamoyladenylate synthase
H1D28_RS17715	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H1D28_RS17720	COG0512	Glutamine amidotransferase of anthranilate synthase
H1D28_RS17720	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H1D28_RS17725	COG0135	phosphoribosylanthranilate isomerase activity
H1D28_RS17725	COG0134	indole-3-glycerol-phosphate synthase activity
H1D28_RS17760	COG4774	siderophore transport
H1D28_RS17770	COG3047	cAMP biosynthetic process
H1D28_RS17775	COG0727	PFAM Uncharacterised protein family (UPF0153)
H1D28_RS17805	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H1D28_RS17810	COG1028	Short-chain dehydrogenase reductase Sdr
H1D28_RS17815	COG1988	membrane-bound metal-dependent
H1D28_RS17830	COG0753	catalase activity
H1D28_RS17840	COG1486	melibiose metabolic process
H1D28_RS17845	COG2169	Transcriptional regulator
H1D28_RS17845	COG1917	Cupin 2, conserved barrel domain protein
H1D28_RS17850	COG1447	Phosphotransferase system cellobiose-specific component IIA
H1D28_RS17855	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H1D28_RS17865	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H1D28_RS17870	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H1D28_RS17880	COG0322	excinuclease ABC activity
H1D28_RS17885	COG3678	ATP-independent chaperone mediated protein folding
H1D28_RS17895	COG3724	N-succinylarginine dihydrolase activity
H1D28_RS17905	COG3138	arginine N-succinyltransferase
H1D28_RS17915	COG0708	Exodeoxyribonuclease III
H1D28_RS17920	COG0398	Pfam SNARE associated Golgi protein
H1D28_RS17925	COG0398	Pfam SNARE associated Golgi protein
H1D28_RS17930	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H1D28_RS17935	COG4134	Bacterial extracellular solute-binding protein
H1D28_RS17940	COG4135	transport system, permease component
H1D28_RS17945	COG4136	ATPase activity
H1D28_RS17950	COG2897	thiosulfate sulfurtransferase activity
H1D28_RS17955	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H1D28_RS17960	COG0494	nUDIX hydrolase
H1D28_RS17965	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H1D28_RS17970	COG0604	alcohol dehydrogenase
H1D28_RS17970	COG3321	synthase
H1D28_RS17970	COG1028	Short-chain dehydrogenase reductase Sdr
H1D28_RS17975	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H1D28_RS17980	COG0709	Synthesizes selenophosphate from selenide and ATP
H1D28_RS17990	COG0778	Nitroreductase
H1D28_RS17995	COG0616	signal peptide processing
H1D28_RS18000	COG0252	asparaginase activity
H1D28_RS18005	COG1335	isochorismatase
H1D28_RS18020	COG3139	Protein of unknown function (DUF1315)
H1D28_RS18040	COG0656	L-ascorbic acid biosynthetic process
H1D28_RS18045	COG3713	MltA-interacting MipA family protein
H1D28_RS18050	COG2766	serine protein kinase
H1D28_RS18065	COG0386	Belongs to the glutathione peroxidase family
H1D28_RS18090	COG1028	Short-chain dehydrogenase reductase Sdr
H1D28_RS18095	COG0583	DNA-binding transcription factor activity
H1D28_RS18100	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H1D28_RS18105	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H1D28_RS18110	COG3344	reverse transcriptase
H1D28_RS18120	COG0859	PFAM glycosyl transferase family 9
H1D28_RS18125	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H1D28_RS18135	COG2207	Transcriptional regulator
H1D28_RS18140	COG2807	transmembrane transport
H1D28_RS18145	COG0504	CTP synthase activity
H1D28_RS18150	COG1683	Conserved Protein
H1D28_RS18155	COG3189	MarR family transcriptional regulator
H1D28_RS18160	COG3042	response to heat
H1D28_RS18165	COG2203	Gaf domain
H1D28_RS18165	COG2199	diguanylate cyclase activity
H1D28_RS18185	COG3182	Iron-regulated membrane protein
H1D28_RS18195	COG1560	Kdo2-lipid A biosynthetic process
H1D28_RS18205	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H1D28_RS18210	COG3706	GGDEF domain
H1D28_RS18215	COG0583	DNA-binding transcription factor activity
H1D28_RS18220	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H1D28_RS18250	COG1294	oxidase, subunit
H1D28_RS18255	COG1271	oxidase subunit
H1D28_RS18265	COG3685	Protein conserved in bacteria
H1D28_RS18270	COG3685	Protein conserved in bacteria
H1D28_RS18275	COG3729	General stress protein
H1D28_RS18285	COG1063	alcohol dehydrogenase
H1D28_RS18290	COG3813	Protein conserved in bacteria
H1D28_RS18310	COG0640	Transcriptional regulator
H1D28_RS18315	COG0538	isocitrate dehydrogenase activity
H1D28_RS18320	COG1187	pseudouridine synthase activity
H1D28_RS18340	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H1D28_RS18360	COG2205	protein histidine kinase activity
H1D28_RS18365	COG2850	peptidyl-arginine hydroxylation
H1D28_RS18385	COG1177	transmembrane transport
H1D28_RS18400	COG0318	PFAM AMP-dependent synthetase and ligase
H1D28_RS18405	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H1D28_RS18410	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H1D28_RS18415	COG0698	ribose 5-phosphate isomerase
H1D28_RS18430	COG3395	kinase activity
H1D28_RS18445	COG2390	Transcriptional regulator
H1D28_RS18455	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H1D28_RS18465	COG4591	ABC-type transport system involved in lipoprotein release permease component
H1D28_RS18475	COG4591	ABC-type transport system involved in lipoprotein release permease component
H1D28_RS18485	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H1D28_RS18490	COG1388	LysM domain
H1D28_RS18490	COG1376	ErfK ybiS ycfS ynhG family protein
H1D28_RS18505	COG1309	transcriptional regulator
H1D28_RS18520	COG3134	Outer membrane lipoprotein
H1D28_RS18525	COG1252	NADH dehydrogenase
H1D28_RS18550	COG5633	Lipoprotein
H1D28_RS18555	COG0537	adenosine 5'-monophosphoramidase activity
H1D28_RS18565	COG0084	hydrolase, TatD family'
H1D28_RS18570	COG0470	DNA polymerase III
H1D28_RS18580	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H1D28_RS18585	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H1D28_RS18590	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H1D28_RS18605	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H1D28_RS18625	COG1399	metal-binding, possibly nucleic acid-binding protein
H1D28_RS18645	COG1530	ribonuclease E activity
H1D28_RS18650	COG0583	DNA-binding transcription factor activity
H1D28_RS18655	COG2814	Major facilitator Superfamily
H1D28_RS18675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H1D28_RS18720	COG1560	Kdo2-lipid A biosynthetic process
H1D28_RS18735	COG5645	(Lipo)protein
H1D28_RS18770	COG3381	protein complex oligomerization
H1D28_RS18800	COG1309	transcriptional regulator
H1D28_RS18805	COG0583	DNA-binding transcription factor activity
H1D28_RS18815	COG1335	isochorismatase
H1D28_RS18825	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H1D28_RS18830	COG1702	phosphate starvation-inducible protein PhoH
H1D28_RS18850	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H1D28_RS18860	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H1D28_RS18875	COG1309	transcriptional regulator
H1D28_RS18910	COG2233	PERMEase
H1D28_RS18920	COG3729	General stress protein
H1D28_RS18950	COG1028	Short-chain dehydrogenase reductase Sdr
H1D28_RS18965	COG0531	amino acid
H1D28_RS18970	COG0174	glutamine synthetase
H1D28_RS18975	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H1D28_RS18980	COG1396	sequence-specific DNA binding
H1D28_RS18980	COG1917	Cupin 2, conserved barrel domain protein
H1D28_RS18985	COG1012	belongs to the aldehyde dehydrogenase family
H1D28_RS18990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1D28_RS18995	COG0583	DNA-binding transcription factor activity
H1D28_RS19000	COG0473	3-isopropylmalate dehydrogenase activity
H1D28_RS19005	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H1D28_RS19010	COG4638	Rieske (2fe-2S)
H1D28_RS19015	COG1012	belongs to the aldehyde dehydrogenase family
H1D28_RS19020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H1D28_RS19045	COG0670	Belongs to the BI1 family
H1D28_RS19060	COG2207	Transcriptional regulator
H1D28_RS19065	COG1881	PFAM PEBP family protein
H1D28_RS19080	COG1832	CoA-binding protein
H1D28_RS19090	COG0210	DNA helicase
H1D28_RS19095	COG3304	Inner membrane component domain
H1D28_RS19100	COG1289	transmembrane transporter activity
H1D28_RS19105	COG3070	regulator of competence-specific genes
H1D28_RS19125	COG1067	ATP-dependent peptidase activity
H1D28_RS19135	COG3130	regulation of translation
H1D28_RS19140	COG3009	Protein conserved in bacteria
H1D28_RS19145	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H1D28_RS19145	COG3008	intermembrane lipid transfer
H1D28_RS19150	COG2995	paraquat-inducible protein a
H1D28_RS19155	COG0488	(ABC) transporter
H1D28_RS19165	COG0633	Ferredoxin
H1D28_RS19165	COG3217	Mosc domain protein beta barrel domain protein
H1D28_RS19180	COG0431	NADPH-dependent FMN reductase
H1D28_RS19185	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H1D28_RS19190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H1D28_RS19195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1D28_RS19205	COG0308	aminopeptidase N
H1D28_RS19215	COG1473	amidohydrolase
H1D28_RS19225	COG0814	amino acid
H1D28_RS19245	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H1D28_RS19250	COG1448	Aminotransferase
H1D28_RS19255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H1D28_RS19260	COG3108	Peptidase M15
H1D28_RS19265	COG2989	Protein conserved in bacteria
H1D28_RS19275	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
H1D28_RS19285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H1D28_RS19290	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H1D28_RS19295	COG3173	Aminoglycoside phosphotransferase
H1D28_RS19310	COG3214	Protein conserved in bacteria
H1D28_RS19325	COG0658	competence protein
H1D28_RS19325	COG2333	competence protein COMEC
H1D28_RS19335	COG0539	negative regulation of cytoplasmic translation
H1D28_RS19355	COG2323	membrane
H1D28_RS19360	COG1944	ATP diphosphatase activity
H1D28_RS19365	COG2116	formate transmembrane transporter activity
H1D28_RS19370	COG1882	Formate acetyltransferase
H1D28_RS19375	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H1D28_RS19380	COG0477	Major facilitator Superfamily
H1D28_RS19385	COG3302	dmso reductase anchor subunit
H1D28_RS19390	COG0437	4 iron, 4 sulfur cluster binding
H1D28_RS19395	COG0243	molybdopterin cofactor binding
H1D28_RS19405	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H1D28_RS19415	COG1674	ftsk spoiiie
H1D28_RS19415	COG1178	ABC-type Fe3 transport system permease component
H1D28_RS19425	COG0492	ferredoxin-NADP+ reductase activity
H1D28_RS19430	COG4988	ABC transporter
H1D28_RS19435	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H1D28_RS19450	COG0542	response to heat
H1D28_RS19460	COG1278	Cold shock
H1D28_RS19470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1D28_RS19475	COG3593	DNA synthesis involved in DNA repair
H1D28_RS19485	COG2431	L-lysine efflux transmembrane transporter activity
H1D28_RS19495	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H1D28_RS19505	COG0028	Belongs to the TPP enzyme family
H1D28_RS19510	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
H1D28_RS19515	COG0702	epimerase
H1D28_RS19520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H1D28_RS19525	COG3023	N-Acetylmuramoyl-L-alanine amidase
H1D28_RS19530	COG4251	negative regulation of phosphorylation
H1D28_RS19530	COG5001	Diguanylate cyclase
H1D28_RS19530	COG3706	GGDEF domain
H1D28_RS19530	COG2203	Gaf domain
H1D28_RS19540	COG1126	abc transporter atp-binding protein
H1D28_RS19545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1D28_RS19550	COG4215	(ABC) transporter
H1D28_RS19555	COG4160	amino acid transport
H1D28_RS19560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1D28_RS19565	COG5002	protein histidine kinase activity
H1D28_RS19570	COG0745	RESPONSE REGULATOR receiver
H1D28_RS19585	COG1177	transmembrane transport
H1D28_RS19590	COG1176	ABC-type spermidine putrescine transport system, permease component I
H1D28_RS19595	COG3842	ATPase activity
H1D28_RS19600	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H1D28_RS19615	COG0778	Nitroreductase
H1D28_RS19640	COG3226	Transcriptional regulator
H1D28_RS19645	COG0738	Major facilitator superfamily
H1D28_RS19650	COG0561	phosphatase activity
H1D28_RS19655	COG2814	Major facilitator Superfamily
H1D28_RS19660	COG0671	phosphoesterase, PA-phosphatase related
H1D28_RS19665	COG1349	DNA-binding transcription factor activity
H1D28_RS19670	COG1686	Belongs to the peptidase S11 family
H1D28_RS19680	COG0625	glutathione transferase activity
H1D28_RS19685	COG2133	pyrroloquinoline quinone binding
H1D28_RS19695	COG2223	nitrite transmembrane transporter activity
H1D28_RS19715	COG0747	negative chemotaxis
H1D28_RS19730	COG0303	'Molybdopterin
H1D28_RS19735	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H1D28_RS19740	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H1D28_RS19745	COG1882	Formate acetyltransferase
H1D28_RS19750	COG0561	phosphatase activity
H1D28_RS19760	COG1609	Transcriptional regulator
H1D28_RS19765	COG2271	Major facilitator Superfamily
H1D28_RS19775	COG0488	(ABC) transporter
H1D28_RS19780	COG2365	Tyrosine phosphatase family
H1D28_RS19785	COG1376	ErfK ybiS ycfS ynhG family protein
H1D28_RS19790	COG2188	Transcriptional regulator
H1D28_RS19795	COG2723	6-phospho-beta-galactosidase activity
H1D28_RS19800	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H1D28_RS19815	COG2194	sulfuric ester hydrolase activity
H1D28_RS19820	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H1D28_RS19835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1D28_RS19840	COG0765	amino acid transport
H1D28_RS19845	COG1126	abc transporter atp-binding protein
H1D28_RS19850	COG0668	transmembrane transport
H1D28_RS19860	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1D28_RS19870	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H1D28_RS19880	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H1D28_RS19885	COG1199	ATP-dependent helicase activity
H1D28_RS19890	COG0513	Belongs to the DEAD box helicase family
H1D28_RS19895	COG3958	Transketolase
H1D28_RS19900	COG3959	Transketolase, thiamine diphosphate binding domain
H1D28_RS19905	COG1028	Short-chain dehydrogenase reductase Sdr
H1D28_RS19910	COG2271	Major facilitator Superfamily
H1D28_RS19920	COG0583	DNA-binding transcription factor activity
H1D28_RS19925	COG1309	transcriptional regulator
H1D28_RS19930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1D28_RS19935	COG1131	(ABC) transporter
H1D28_RS19940	COG0842	Transport permease protein
H1D28_RS19945	COG0842	Transport permease protein
H1D28_RS19955	COG3568	Endonuclease Exonuclease Phosphatase
H1D28_RS19960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H1D28_RS19965	COG0392	lysyltransferase activity
H1D28_RS19970	COG0670	Belongs to the BI1 family
H1D28_RS19975	COG0314	molybdopterin synthase activity
H1D28_RS19980	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H1D28_RS19990	COG0521	Mo-molybdopterin cofactor biosynthetic process
H1D28_RS20010	COG0745	RESPONSE REGULATOR receiver
H1D28_RS20015	COG0642	Histidine kinase
H1D28_RS20040	COG2226	methyltransferase
H1D28_RS20055	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H1D28_RS20060	COG1881	PFAM PEBP family protein
H1D28_RS20100	COG4677	pectinesterase activity
H1D28_RS20110	COG0589	response to stress
H1D28_RS20115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1D28_RS20150	COG0789	Transcriptional regulator
H1D28_RS20155	COG2200	EAL domain
H1D28_RS20180	COG0561	phosphatase activity
H1D28_RS20190	COG4149	molybdate abc transporter
H1D28_RS20195	COG0725	ABC transporter, periplasmic molybdate-binding protein
H1D28_RS20205	COG3585	molybdate ion transport
H1D28_RS20205	COG2005	Transcriptional regulator
H1D28_RS20210	COG1119	ATPase activity
H1D28_RS20220	COG1085	galactose-1-phosphate uridylyltransferase
H1D28_RS20230	COG2017	converts alpha-aldose to the beta-anomer
H1D28_RS20240	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H1D28_RS20255	COG3201	nicotinamide mononucleotide transporter
H1D28_RS20260	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H1D28_RS20310	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
H1D28_RS20315	COG2885	chlorophyll binding
H1D28_RS20325	COG3064	Membrane
H1D28_RS20325	COG3064	Membrane
H1D28_RS20330	COG0848	biopolymer transport protein
H1D28_RS20335	COG0811	peptide transport
H1D28_RS20340	COG0824	Thioesterase
H1D28_RS20345	COG3790	cyd operon protein YbgE
H1D28_RS20350	COG4890	Cyd operon protein YbgT
H1D28_RS20355	COG1294	oxidase, subunit
H1D28_RS20360	COG1271	oxidase subunit
H1D28_RS20365	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H1D28_RS20375	COG0508	dehydrogenase complex catalyzes the overall conversion of
H1D28_RS20380	COG0567	Dehydrogenase, E1 component
H1D28_RS20385	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H1D28_RS20390	COG1053	succinate dehydrogenase
H1D28_RS20395	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H1D28_RS20400	COG2009	succinate dehydrogenase
H1D28_RS20435	COG1984	allophanate hydrolase subunit 2
H1D28_RS20440	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H1D28_RS20455	COG0415	Belongs to the DNA photolyase family
H1D28_RS20485	COG2205	protein histidine kinase activity
H1D28_RS20490	COG0745	RESPONSE REGULATOR receiver
H1D28_RS20500	COG0033	Phosphoglucomutase
H1D28_RS20510	COG0596	Alpha beta hydrolase
H1D28_RS20525	COG0735	belongs to the Fur family
H1D28_RS20565	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H1D28_RS20570	COG1846	Transcriptional regulator
H1D28_RS20570	COG1940	carbohydrate kinase activity
H1D28_RS20575	COG0647	UMP catabolic process
H1D28_RS20580	COG0367	asparagine synthase
H1D28_RS20620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H1D28_RS20630	COG1702	phosphate starvation-inducible protein PhoH
H1D28_RS20655	COG0765	amino acid transport
H1D28_RS20660	COG0765	amino acid transport
H1D28_RS20665	COG1126	abc transporter atp-binding protein
H1D28_RS20680	COG2888	peptidyl-tyrosine sulfation
H1D28_RS20695	COG1466	dna polymerase III delta subunit
H1D28_RS20710	COG0799	negative regulation of ribosome biogenesis
H1D28_RS20720	COG0768	penicillin binding
H1D28_RS20725	COG0772	Belongs to the SEDS family
H1D28_RS20730	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H1D28_RS20735	COG1686	Belongs to the peptidase S11 family
H1D28_RS20750	COG0583	DNA-binding transcription factor activity
H1D28_RS20765	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H1D28_RS20785	COG3069	C4-dicarboxylate transmembrane transporter activity
H1D28_RS20790	COG3719	Belongs to the RNase T2 family
H1D28_RS20795	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H1D28_RS20815	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H1D28_RS20820	COG0583	DNA-binding transcription factor activity
H1D28_RS20825	COG3969	phosphoadenosine phosphosulfate
H1D28_RS20830	COG1475	DNA binding
H1D28_RS20835	COG0436	Aminotransferase
H1D28_RS20860	COG1129	ABC transporter
H1D28_RS20865	COG1172	Belongs to the binding-protein-dependent transport system permease family
H1D28_RS20870	COG1172	Belongs to the binding-protein-dependent transport system permease family
H1D28_RS20880	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H1D28_RS20895	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H1D28_RS20905	COG0402	S-adenosylhomocysteine deaminase activity
H1D28_RS20915	COG0483	inositol monophosphate 1-phosphatase activity
H1D28_RS20920	COG2271	Major facilitator Superfamily
H1D28_RS20950	COG1172	Belongs to the binding-protein-dependent transport system permease family
H1D28_RS20955	COG1129	ABC transporter
H1D28_RS20960	COG0371	Dehydrogenase
H1D28_RS20965	COG1028	Short-chain dehydrogenase reductase Sdr
H1D28_RS20980	COG2879	small protein
H1D28_RS20985	COG1966	Carbon starvation protein
H1D28_RS20995	COG1028	Short-chain dehydrogenase reductase Sdr
H1D28_RS21000	COG3433	isochorismatase activity
H1D28_RS21000	COG1535	isochorismatase
H1D28_RS21005	COG1021	2,3-dihydroxybenzoate-AMP ligase
H1D28_RS21010	COG1169	isochorismate synthase
H1D28_RS21015	COG4592	Periplasmic binding protein
H1D28_RS21025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1D28_RS21030	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1D28_RS21035	COG1120	ATPase activity
H1D28_RS21040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H1D28_RS21040	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
H1D28_RS21045	COG3251	PFAM MbtH domain protein
H1D28_RS21050	COG2382	esterase
H1D28_RS21055	COG4771	TonB-dependent receptor
H1D28_RS21065	COG1879	ABC-type sugar transport system periplasmic component
H1D28_RS21075	COG1129	ABC transporter
H1D28_RS21080	COG1172	Belongs to the binding-protein-dependent transport system permease family
H1D28_RS21085	COG5464	transposase or invertase
H1D28_RS21090	COG2390	Transcriptional regulator
H1D28_RS21095	COG3959	Transketolase, thiamine diphosphate binding domain
H1D28_RS21100	COG3958	Transketolase
H1D28_RS21110	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H1D28_RS21120	COG0583	DNA-binding transcription factor activity
H1D28_RS21125	COG0668	transmembrane transport
H1D28_RS21135	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H1D28_RS21160	COG0747	negative chemotaxis
H1D28_RS21165	COG0601	transmembrane transport
H1D28_RS21170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1D28_RS21175	COG0444	Belongs to the ABC transporter superfamily
H1D28_RS21180	COG4608	Belongs to the ABC transporter superfamily
H1D28_RS21190	COG4221	oxidoreductase activity
H1D28_RS21200	COG4215	(ABC) transporter
H1D28_RS21205	COG0765	amino acid transport
H1D28_RS21210	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H1D28_RS21225	COG0697	spore germination
H1D28_RS21240	COG4608	Belongs to the ABC transporter superfamily
H1D28_RS21245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H1D28_RS21255	COG4166	transmembrane transport
H1D28_RS21265	COG3698	Phosphodiester glycosidase
H1D28_RS21305	COG2315	Protein conserved in bacteria
H1D28_RS21310	COG0778	Nitroreductase
H1D28_RS21320	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H1D28_RS21330	COG3716	PTS system mannose fructose sorbose family IID component
H1D28_RS21335	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H1D28_RS21340	COG2222	sugar isomerase
H1D28_RS21345	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H1D28_RS21345	COG3933	PFAM sigma-54 factor interaction domain-containing protein
H1D28_RS21360	COG0477	Major facilitator Superfamily
H1D28_RS21365	COG0668	transmembrane transport
H1D28_RS21380	COG0673	inositol 2-dehydrogenase activity
H1D28_RS21390	COG2211	Major facilitator Superfamily
H1D28_RS21395	COG1113	amino acid transport
H1D28_RS21410	COG1012	belongs to the aldehyde dehydrogenase family
H1D28_RS21415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1D28_RS21425	COG0531	amino acid
H1D28_RS21440	COG4680	protein conserved in bacteria
H1D28_RS21480	COG0667	Aldo Keto reductase
H1D28_RS21485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1D28_RS21490	COG1473	amidohydrolase
H1D28_RS21520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1D28_RS21525	COG1120	ATPase activity
H1D28_RS21530	COG1566	PFAM secretion protein HlyD family protein
H1D28_RS21575	COG4211	Belongs to the binding-protein-dependent transport system permease family
H1D28_RS21580	COG1129	ABC transporter
H1D28_RS21595	COG0673	inositol 2-dehydrogenase activity
H1D28_RS21625	COG3104	oligopeptide transport
H1D28_RS21630	COG1982	Orn Lys Arg decarboxylase major
H1D28_RS21635	COG0531	amino acid
H1D28_RS21640	COG3710	Transcriptional regulator
H1D28_RS21650	COG1560	Kdo2-lipid A biosynthetic process
H1D28_RS21665	COG3188	usher protein
H1D28_RS21670	COG3121	Chaperone
H1D28_RS21675	COG3539	Fimbrial protein
H1D28_RS21725	COG3344	reverse transcriptase
H1D28_RS21870	COG3772	lysozyme
H1D28_RS21975	COG3756	Protein conserved in bacteria
H1D28_RS22070	COG2501	S4 domain
H1D28_RS22080	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H1D28_RS22095	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H1D28_RS22100	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H1D28_RS22120	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H1D28_RS22125	COG4181	ATPase activity
H1D28_RS22135	COG0300	oxidoreductase activity
H1D28_RS22140	COG3118	belongs to the thioredoxin family
H1D28_RS22145	COG0390	transport system, permease component
H1D28_RS22150	COG4619	ABC transporter
H1D28_RS22155	COG0330	HflC and HflK could
H1D28_RS22160	COG1585	Membrane protein implicated in regulation of membrane protease activity
H1D28_RS22175	COG3735	TraB family
H1D28_RS22180	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H1D28_RS22190	COG2223	nitrite transmembrane transporter activity
H1D28_RS22195	COG4651	solute:proton antiporter activity
H1D28_RS22195	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H1D28_RS22200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H1D28_RS22240	COG2832	Protein of unknown function (DUF454)
H1D28_RS22245	COG3923	Primosomal replication protein n
H1D28_RS22255	COG5464	transposase or invertase
H1D28_RS22260	COG1196	nuclear chromosome segregation
H1D28_RS22260	COG3264	Mechanosensitive ion channel
H1D28_RS22265	COG1309	transcriptional regulator
H1D28_RS22270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1D28_RS22275	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H1D28_RS22290	COG0110	maltose O-acetyltransferase activity
H1D28_RS22340	COG1874	Beta-galactosidase
H1D28_RS22345	COG3867	Arabinogalactan endo-beta-1,4-galactanase
H1D28_RS22350	COG3833	ABC-type maltose transport systems, permease component
H1D28_RS22355	COG1175	transmembrane transport
H1D28_RS22360	COG2182	Extracellular solute-binding protein
H1D28_RS22370	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H1D28_RS22385	COG2364	Membrane
H1D28_RS22415	COG3695	enzyme binding
H1D28_RS22420	COG3126	Type III secretion system lipoprotein chaperone (YscW)
H1D28_RS22425	COG1946	Acyl-CoA thioesterase
H1D28_RS22430	COG0004	ammonium transporteR
H1D28_RS22435	COG0347	Belongs to the P(II) protein family
H1D28_RS22440	COG1132	(ABC) transporter
H1D28_RS22445	COG1132	(ABC) transporter
H1D28_RS22450	COG1522	sequence-specific DNA binding
H1D28_RS22465	COG4533	DNA binding
H1D28_RS22475	COG0824	Thioesterase
H1D28_RS22480	COG1555	photosystem II stabilization
H1D28_RS22485	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H1D28_RS22490	COG0776	regulation of translation
H1D28_RS22495	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H1D28_RS22515	COG0271	Belongs to the BolA IbaG family
H1D28_RS22520	COG3056	Lipoprotein
H1D28_RS22525	COG2223	nitrite transmembrane transporter activity
H1D28_RS22530	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H1D28_RS22535	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H1D28_RS22540	COG1845	cytochrome c oxidase, subunit III
H1D28_RS22545	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H1D28_RS22560	COG1414	Transcriptional regulator
H1D28_RS22565	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H1D28_RS22570	COG1053	succinate dehydrogenase
H1D28_RS22580	COG1053	succinate dehydrogenase
H1D28_RS22595	COG0673	inositol 2-dehydrogenase activity
H1D28_RS22600	COG2814	Major facilitator Superfamily
H1D28_RS22610	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H1D28_RS22615	COG0693	protein deglycase activity
H1D28_RS22635	COG0142	geranyltranstransferase activity
H1D28_RS22645	COG0667	Aldo Keto reductase
H1D28_RS22650	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H1D28_RS22670	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H1D28_RS22670	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H1D28_RS22680	COG4238	major outer membrane lipoprotein
H1D28_RS22700	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H1D28_RS22705	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H1D28_RS22710	COG1862	Preprotein translocase
H1D28_RS22735	COG0450	alkyl hydroperoxide reductase
H1D28_RS22740	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H1D28_RS22755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H1D28_RS22765	COG1228	amidohydrolase
H1D28_RS22775	COG1335	isochorismatase
H1D28_RS22780	COG0583	DNA-binding transcription factor activity
H1D28_RS22785	COG0366	Alpha amylase catalytic
H1D28_RS22810	COG0420	3'-5' exonuclease activity
H1D28_RS22815	COG0419	ATPase involved in DNA repair
H1D28_RS22820	COG1940	carbohydrate kinase activity
H1D28_RS22835	COG4126	flavin adenine dinucleotide binding
H1D28_RS22845	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H1D28_RS22850	COG3416	Protein conserved in bacteria
H1D28_RS22860	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H1D28_RS22870	COG1785	Belongs to the alkaline phosphatase family
H1D28_RS22910	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
H1D28_RS22915	COG1335	isochorismatase
H1D28_RS22920	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H1D28_RS22925	COG0113	porphobilinogen synthase activity
H1D28_RS22930	COG1943	Transposase
H1D28_RS22940	COG2175	clavaminate synthase activity
H1D28_RS22945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H1D28_RS22950	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H1D28_RS22955	COG4521	taurine ABC transporter
H1D28_RS22960	COG2040	homocysteine
H1D28_RS22965	COG0833	amino acid
H1D28_RS22980	COG4303	Ethanolamine ammonia lyase large subunit
H1D28_RS22985	COG4302	ethanolamine ammonia-lyase activity
H1D28_RS23025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1D28_RS23030	COG1126	abc transporter atp-binding protein
H1D28_RS23035	COG4597	amino acid ABC transporter
H1D28_RS23040	COG0765	amino acid transport
H1D28_RS23055	COG3188	usher protein
H1D28_RS23080	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
H1D28_RS23090	COG3639	organic phosphonate transmembrane transporter activity
H1D28_RS23115	COG0791	NLP P60 protein
H1D28_RS23140	COG0582	viral genome integration into host DNA
H1D28_RS23175	COG3121	Chaperone
H1D28_RS23180	COG3188	usher protein
H1D28_RS23210	COG2909	trisaccharide binding
H1D28_RS23215	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H1D28_RS23220	COG0022	dehydrogenase e1 component
H1D28_RS23225	COG0508	dehydrogenase complex catalyzes the overall conversion of
H1D28_RS23230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H1D28_RS23250	COG1070	Carbohydrate kinase
H1D28_RS23255	COG1028	Short-chain dehydrogenase reductase Sdr
H1D28_RS23260	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H1D28_RS23265	COG3775	system Galactitol-specific IIC component
H1D28_RS23270	COG0625	glutathione transferase activity
H1D28_RS23275	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
H1D28_RS23290	COG0579	oxidoreductase
H1D28_RS23295	COG1012	belongs to the aldehyde dehydrogenase family
H1D28_RS23300	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H1D28_RS23305	COG1113	amino acid transport
H1D28_RS23310	COG1802	Transcriptional regulator
H1D28_RS23330	COG2195	Cleaves the N-terminal amino acid of tripeptides
H1D28_RS23335	COG0454	-acetyltransferase
H1D28_RS23350	COG2991	Protein conserved in bacteria
H1D28_RS23365	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H1D28_RS23370	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H1D28_RS23385	COG3034	peptidoglycan biosynthetic process
H1D28_RS23390	COG0121	glutamine amidotransferase
H1D28_RS23400	COG1960	acyl-CoA dehydrogenase activity
H1D28_RS23405	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H1D28_RS23415	COG0583	DNA-binding transcription factor activity
H1D28_RS23425	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H1D28_RS23435	COG2226	methyltransferase
H1D28_RS23445	COG0741	lytic transglycosylase activity
H1D28_RS23445	COG1388	LysM domain
H1D28_RS23450	COG2226	methyltransferase
H1D28_RS23460	COG2814	Major facilitator Superfamily
H1D28_RS23465	COG0583	DNA-binding transcription factor activity
H1D28_RS23470	COG0656	L-ascorbic acid biosynthetic process
H1D28_RS23505	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H1D28_RS23515	COG2011	ABC-type metal ion transport system permease component
H1D28_RS23520	COG1464	Belongs to the NlpA lipoprotein family
H1D28_RS23530	COG1720	tRNA m6t6A37 methyltransferase activity
H1D28_RS23540	COG0791	NLP P60 protein
H1D28_RS23545	COG3015	lipoprotein NlpE involved in copper resistance
H1D28_RS23550	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H1D28_RS23565	COG4568	rho-dependent transcription termination
H1D28_RS23575	COG0346	lactoylglutathione lyase activity
H1D28_RS23590	COG0587	DNA-directed DNA polymerase activity
H1D28_RS23620	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
H1D28_RS23630	COG0750	zinc metalloprotease
H1D28_RS23635	COG0575	Belongs to the CDS family
H1D28_RS23645	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H1D28_RS23670	COG0024	Methionine aminopeptidase
H1D28_RS23675	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H1D28_RS23690	COG3835	regulator
H1D28_RS23695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H1D28_RS23715	COG2860	membrane
H1D28_RS23735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H1D28_RS23740	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H1D28_RS23745	COG1120	ATPase activity
H1D28_RS23750	COG4774	siderophore transport
H1D28_RS23755	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H1D28_RS23845	COG1643	Atp-dependent helicase
H1D28_RS23850	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
H1D28_RS23870	COG0617	tRNA 3'-terminal CCA addition
H1D28_RS23875	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H1D28_RS23895	COG0726	polysaccharide deacetylase
H1D28_RS23900	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H1D28_RS23905	COG0842	Transport permease protein
H1D28_RS23910	COG1131	(ABC) transporter
H1D28_RS23915	COG0288	reversible hydration of carbon dioxide
H1D28_RS23930	COG4993	Dehydrogenase
H1D28_RS23935	COG2132	Multicopper oxidase
H1D28_RS23975	COG3064	Membrane
H1D28_RS23990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H1D28_RS23995	COG0508	dehydrogenase complex catalyzes the overall conversion of
H1D28_RS24000	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H1D28_RS24005	COG2186	Transcriptional regulator
H1D28_RS24010	COG1113	amino acid transport
H1D28_RS24015	COG2211	Major facilitator Superfamily
H1D28_RS24020	COG3940	Belongs to the glycosyl hydrolase 43 family
H1D28_RS24030	COG3023	N-Acetylmuramoyl-L-alanine amidase
H1D28_RS24040	COG4969	Belongs to the N-Me-Phe pilin family
H1D28_RS24045	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H1D28_RS24050	COG1459	type II secretion system
H1D28_RS24075	COG0494	nUDIX hydrolase
H1D28_RS24095	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H1D28_RS24100	COG0849	cell division
H1D28_RS24125	COG0772	Belongs to the SEDS family
H1D28_RS24140	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H1D28_RS24145	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H1D28_RS24150	COG0768	penicillin binding
H1D28_RS24170	COG1609	Transcriptional regulator
H1D28_RS24180	COG0028	Belongs to the TPP enzyme family
H1D28_RS24225	COG0738	Major facilitator superfamily
H1D28_RS24235	COG0583	DNA-binding transcription factor activity
H1D28_RS24240	COG2271	Major facilitator Superfamily
H1D28_RS24245	COG2814	Major facilitator Superfamily
H1D28_RS24265	COG1178	ABC-type Fe3 transport system permease component
H1D28_RS24275	COG0586	Pfam SNARE associated Golgi protein
H1D28_RS24295	COG0235	Class ii aldolase
H1D28_RS24300	COG0417	DNA replication proofreading
H1D28_RS24310	COG0564	pseudouridine synthase activity
H1D28_RS24320	COG3493	citrate carrier protein
H1D28_RS24335	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H1D28_RS24340	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H1D28_RS24350	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H1D28_RS24395	COG0505	Belongs to the CarA family
H1D28_RS24460	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H1D28_RS24485	COG1047	Peptidyl-prolyl cis-trans
H1D28_RS24500	COG0196	riboflavin kinase activity
H1D28_RS24510	COG0583	DNA-binding transcription factor activity
H1D28_RS24535	COG4735	regulation of single-species biofilm formation
H1D28_RS24540	COG1584	GPR1 FUN34 yaaH family protein
H1D28_RS24545	COG0477	Major facilitator Superfamily
H1D28_RS24550	COG0521	Mo-molybdopterin cofactor biosynthetic process
H1D28_RS24555	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H1D28_RS24560	COG1115	amino acid carrier protein
H1D28_RS24575	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H1D28_RS24585	COG0527	aspartate kinase activity
H1D28_RS24585	COG0460	homoserine dehydrogenase
H1D28_RS24595	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
H1D28_RS24605	COG0745	RESPONSE REGULATOR receiver
H1D28_RS24610	COG4452	Inner membrane protein CreD
H1D28_RS24615	COG2205	protein histidine kinase activity
H1D28_RS24620	COG0745	RESPONSE REGULATOR receiver
H1D28_RS24625	COG3045	CreA protein
H1D28_RS24630	COG3708	Transcriptional regulator
H1D28_RS24630	COG2207	Transcriptional regulator
H1D28_RS24650	COG0741	lytic transglycosylase activity
H1D28_RS24655	COG0488	(ABC) transporter
H1D28_RS24665	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H1D28_RS24670	COG0560	Phosphoserine phosphatase
H1D28_RS24675	COG3726	membrane protein affecting hemolysin expression
H1D28_RS24705	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H1D28_RS24710	COG0084	hydrolase, TatD family'
H1D28_RS24715	COG4667	esterase of the alpha-beta hydrolase superfamily
H1D28_RS24725	COG2823	Periplasmic or secreted lipoprotein
H1D28_RS24735	COG1011	Hydrolase
H1D28_RS24740	COG0456	acetyltransferase
H1D28_RS24745	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
H1D28_RS24780	COG3706	GGDEF domain
H1D28_RS24785	COG4114	ferric iron reductase
H1D28_RS24790	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H1D28_RS24790	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H1D28_RS24795	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H1D28_RS24800	COG2197	response regulator
H1D28_RS24805	COG2197	response regulator
H1D28_RS24820	COG2966	Psort location CytoplasmicMembrane, score
H1D28_RS24835	COG1484	DNA-dependent DNA replication
H1D28_RS24850	COG5464	transposase or invertase
H1D28_RS24860	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H1D28_RS24865	COG3716	PTS system mannose fructose sorbose family IID component
H1D28_RS24870	COG3715	PTS system
H1D28_RS24885	COG3933	PFAM sigma-54 factor interaction domain-containing protein
H1D28_RS24885	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H1D28_RS24890	COG1214	PFAM Peptidase M22, glycoprotease
H1D28_RS24890	COG0456	acetyltransferase
H1D28_RS24900	COG1737	Transcriptional regulator
H1D28_RS24905	COG0800	Aldolase
H1D28_RS24910	COG3734	2-keto-3-deoxy-galactonokinase
H1D28_RS24925	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
H1D28_RS24945	COG0531	amino acid
H1D28_RS24950	COG1012	belongs to the aldehyde dehydrogenase family
H1D28_RS24955	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H1D28_RS24970	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H1D28_RS24970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H1D28_RS24985	COG1846	Transcriptional regulator
H1D28_RS24995	COG0179	Fumarylacetoacetate (FAA) hydrolase
H1D28_RS25005	COG1012	belongs to the aldehyde dehydrogenase family
H1D28_RS25010	COG3384	dioxygenase
H1D28_RS25020	COG3971	2-oxopent-4-enoate hydratase activity
H1D28_RS25040	COG2368	4-hydroxyphenylacetate
H1D28_RS25045	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H1D28_RS25060	COG1966	Carbon starvation protein
H1D28_RS25065	COG2879	small protein
H1D28_RS25070	COG0523	cobalamin synthesis protein
H1D28_RS25080	COG1012	belongs to the aldehyde dehydrogenase family
H1D28_RS25085	COG5464	transposase or invertase
H1D28_RS25090	COG2207	Transcriptional regulator
H1D28_RS25090	COG1917	Cupin 2, conserved barrel domain protein
H1D28_RS25100	COG2733	membrane
H1D28_RS25115	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
H1D28_RS25120	COG1924	4 iron, 4 sulfur cluster binding
H1D28_RS25135	COG1566	PFAM secretion protein HlyD family protein
H1D28_RS25145	COG5457	Domain of unknown function (DUF1127)
H1D28_RS25150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H1D28_RS25185	COG0583	DNA-binding transcription factor activity
H1D28_RS25190	COG2249	NAD(P)H dehydrogenase (quinone) activity
H1D28_RS25200	COG1172	Belongs to the binding-protein-dependent transport system permease family
H1D28_RS25205	COG1129	ABC transporter
H1D28_RS25210	COG1879	ABC-type sugar transport system periplasmic component
H1D28_RS25220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1D28_RS25225	COG1129	ABC transporter
H1D28_RS25225	COG0842	Transport permease protein
H1D28_RS25230	COG0842	Transport permease protein
H1D28_RS25260	COG2850	peptidyl-arginine hydroxylation
H1D28_RS25275	COG5002	protein histidine kinase activity
H1D28_RS25280	COG0745	RESPONSE REGULATOR receiver
H1D28_RS25285	COG1538	Outer membrane efflux protein
H1D28_RS25290	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1D28_RS25295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H1D28_RS25300	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H1D28_RS25310	COG3040	lipid binding
H1D28_RS25315	COG0789	Transcriptional regulator
H1D28_RS25325	COG0300	oxidoreductase activity
H1D28_RS25340	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H1D28_RS25360	COG3272	Protein of unknown function (DUF1722)
H1D28_RS25365	COG4580	involved in the transport of maltose and maltodextrins
H1D28_RS25370	COG2115	Belongs to the xylose isomerase family
H1D28_RS25375	COG2211	Major facilitator Superfamily
H1D28_RS25380	COG3507	Belongs to the glycosyl hydrolase 43 family
H1D28_RS25470	COG1715	Restriction endonuclease
H1D28_RS25475	COG1196	nuclear chromosome segregation
H1D28_RS25495	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
H1D28_RS25500	COG0582	viral genome integration into host DNA
H1D28_RS25510	COG0288	reversible hydration of carbon dioxide
H1D28_RS25515	COG0659	secondary active sulfate transmembrane transporter activity
H1D28_RS25520	COG1064	alcohol dehydrogenase
H1D28_RS25525	COG1175	transmembrane transport
H1D28_RS25530	COG0395	ABC-type sugar transport system, permease component
H1D28_RS25535	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H1D28_RS25540	COG3842	ATPase activity
H1D28_RS25555	COG1082	Xylose isomerase domain protein TIM barrel
H1D28_RS25565	COG3962	Belongs to the TPP enzyme family
H1D28_RS25570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H1D28_RS25575	COG1737	Transcriptional regulator
H1D28_RS25575	COG0837	glucose binding
H1D28_RS25580	COG3718	enzyme involved in inositol metabolism
H1D28_RS25595	COG0433	COG0433 Predicted ATPase
H1D28_RS25600	COG0795	lipopolysaccharide-transporting ATPase activity
H1D28_RS25605	COG0795	lipopolysaccharide-transporting ATPase activity
H1D28_RS25615	COG2927	DNA polymerase III (CHI subunit)
H1D28_RS25620	COG0525	valine-tRNA ligase activity
H1D28_RS25645	COG2731	YhcH YjgK YiaL family protein
H1D28_RS25680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H1D28_RS25680	COG1263	PTS System
H1D28_RS25685	COG0366	Alpha amylase catalytic
H1D28_RS25690	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H1D28_RS25695	COG1486	melibiose metabolic process
H1D28_RS25720	COG0602	queuosine metabolic process
H1D28_RS25725	COG2026	Addiction module toxin, RelE StbE family
H1D28_RS25730	COG3077	Addiction module antitoxin, RelB DinJ family
H1D28_RS25735	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H1D28_RS25735	COG3711	transcriptional antiterminator
H1D28_RS25740	COG2706	6-phosphogluconolactonase activity
H1D28_RS25755	COG3964	amidohydrolase
H1D28_RS25790	COG0312	modulator of DNA gyrase
H1D28_RS25815	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H1D28_RS25825	COG1172	Belongs to the binding-protein-dependent transport system permease family
H1D28_RS25830	COG1172	Belongs to the binding-protein-dependent transport system permease family
H1D28_RS25835	COG1129	ABC transporter
H1D28_RS25840	COG1879	ABC-type sugar transport system periplasmic component
H1D28_RS25860	COG2105	PFAM AIG2 family protein
H1D28_RS25865	COG2911	Protein conserved in bacteria
H1D28_RS25870	COG0729	surface antigen
H1D28_RS25880	COG1253	flavin adenine dinucleotide binding
H1D28_RS25895	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
H1D28_RS25910	COG1733	regulation of RNA biosynthetic process
H1D28_RS25915	COG0702	epimerase
H1D28_RS25925	COG0697	spore germination
H1D28_RS25935	COG1113	amino acid transport
H1D28_RS25940	COG0545	Peptidyl-prolyl cis-trans isomerase
H1D28_RS25945	COG3061	Opacity-associated protein A
H1D28_RS25955	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H1D28_RS25960	COG2965	DNA replication, synthesis of RNA primer
H1D28_RS26020	COG1073	alpha beta
H1D28_RS26025	COG3650	response to hydrogen peroxide
H1D28_RS26035	COG1960	acyl-CoA dehydrogenase activity
H1D28_RS26040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H1D28_RS26045	COG0557	exoribonuclease II activity
H1D28_RS26060	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
H1D28_RS26070	COG0330	HflC and HflK could
H1D28_RS26075	COG0330	HflC and HflK could
H1D28_RS26080	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H1D28_RS26100	COG0860	N-Acetylmuramoyl-L-alanine amidase
H1D28_RS26105	COG0802	atpase or kinase
H1D28_RS26110	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H1D28_RS26110	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H1D28_RS26115	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H1D28_RS26135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H1D28_RS26155	COG1511	domain protein
H1D28_RS26155	COG3264	Mechanosensitive ion channel
H1D28_RS26170	COG1053	succinate dehydrogenase
H1D28_RS26175	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H1D28_RS26195	COG2076	Multidrug Resistance protein
H1D28_RS26200	COG5510	response to toxic substance
H1D28_RS26215	COG1509	lysine 2,3-aminomutase activity
H1D28_RS26280	COG0531	amino acid
H1D28_RS26285	COG3030	protein affecting phage T7 exclusion by the F plasmid
H1D28_RS26290	COG1027	Aspartate ammonia-lyase
H1D28_RS26295	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H1D28_RS26310	COG1309	transcriptional regulator
H1D28_RS26355	COG0457	Tetratricopeptide repeat
H1D28_RS26360	COG1649	PFAM Uncharacterised BCR, COG1649
H1D28_RS26360	COG0726	polysaccharide deacetylase
H1D28_RS26365	COG1215	transferase activity, transferring glycosyl groups
H1D28_RS26380	COG0861	Integral membrane protein TerC family
H1D28_RS26425	COG1486	melibiose metabolic process
H1D28_RS26430	COG2169	Transcriptional regulator
H1D28_RS26440	COG2824	Alkylphosphonate utilization operon protein PhnA
H1D28_RS26445	COG2764	glyoxalase bleomycin resistance protein dioxygenase
H1D28_RS26450	COG2188	Transcriptional regulator
H1D28_RS26455	COG3624	Phosphonate C-P lyase system protein PhnG
H1D28_RS26460	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
H1D28_RS26465	COG3626	phosphonate metabolism
H1D28_RS26470	COG3627	carbon phosphorus lyase activity
H1D28_RS26475	COG4107	phosphonate C-P lyase system protein PhnK
H1D28_RS26480	COG4778	phosphonate C-P lyase system protein PhnL
H1D28_RS26485	COG3454	Phosphonate metabolism
H1D28_RS26495	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H1D28_RS26505	COG4191	Histidine kinase
H1D28_RS26505	COG0784	Response regulator, receiver
H1D28_RS26510	COG1129	ABC transporter
H1D28_RS26515	COG1172	Belongs to the binding-protein-dependent transport system permease family
H1D28_RS26555	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
H1D28_RS26560	COG1301	dicarboxylic acid transport
H1D28_RS26570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H1D28_RS26575	COG3162	membrane
H1D28_RS26605	COG3539	Fimbrial protein
H1D28_RS26610	COG1346	cytolysis
H1D28_RS26615	COG1380	Effector of murein hydrolase LrgA
H1D28_RS26620	COG0583	DNA-binding transcription factor activity
H1D28_RS26625	COG0025	NhaP-type Na H and K H
H1D28_RS26630	COG2252	PERMEase
H1D28_RS26635	COG0625	glutathione transferase activity
H1D28_RS26640	COG0789	Transcriptional regulator
H1D28_RS26650	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H1D28_RS26680	COG1234	tRNA 3'-trailer cleavage
H1D28_RS26685	COG1609	Transcriptional regulator
H1D28_RS26690	COG0483	inositol monophosphate 1-phosphatase activity
H1D28_RS26700	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H1D28_RS26720	COG4771	TonB-dependent receptor
H1D28_RS26725	COG0741	lytic transglycosylase activity
H1D28_RS26740	COG2315	Protein conserved in bacteria
H1D28_RS26745	COG0432	Pfam Uncharacterised protein family UPF0047
H1D28_RS26760	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H1D28_RS26765	COG0305	Participates in initiation and elongation during chromosome replication
H1D28_RS26780	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H1D28_RS26790	COG0735	belongs to the Fur family
H1D28_RS26795	COG3237	CsbD-like
H1D28_RS26805	COG0534	Mate efflux family protein
H1D28_RS26815	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H1D28_RS26885	COG0251	oxidation-reduction process
H1D28_RS26895	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H1D28_RS26905	COG0527	aspartate kinase activity
H1D28_RS26960	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H1D28_RS26990	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H1D28_RS27000	COG0456	acetyltransferase
H1D28_RS27030	COG0151	Belongs to the GarS family
H1D28_RS27040	COG4191	Histidine kinase
H1D28_RS27045	COG3678	ATP-independent chaperone mediated protein folding
H1D28_RS27080	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
H1D28_RS27095	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H1D28_RS27100	COG2104	thiamine diphosphate biosynthetic process
H1D28_RS27115	COG3706	GGDEF domain
H1D28_RS27125	COG1447	Phosphotransferase system cellobiose-specific component IIA
H1D28_RS27130	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H1D28_RS27165	COG0250	Participates in transcription elongation, termination and antitermination
H1D28_RS27240	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
H1D28_RS27250	COG1739	Uncharacterized protein family UPF0029
H1D28_RS27290	COG0805	protein transport
H1D28_RS27310	COG3165	ubiquinone biosynthetic process from chorismate
H1D28_RS27340	COG0583	DNA-binding transcription factor activity
H1D28_RS27345	COG0697	spore germination
H1D28_RS27350	COG0561	phosphatase activity
H1D28_RS27355	COG2267	carboxylic ester hydrolase activity
H1D28_RS27360	COG1280	lysine exporter protein (LysE YggA)
H1D28_RS27370	COG1280	lysine exporter protein (LysE YggA)
H1D28_RS27400	COG0210	DNA helicase
H1D28_RS27405	COG1011	Hydrolase
H1D28_RS27435	COG3072	Adenylate cyclase
H1D28_RS27450	COG2959	enzyme of heme biosynthesis
H1D28_RS27455	COG3071	HemY protein
H1D28_RS27500	COG2244	polysaccharide biosynthetic process
H1D28_RS27505	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H1D28_RS27510	COG0456	acetyltransferase
H1D28_RS27515	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H1D28_RS27520	COG1088	dTDP-glucose 4,6-dehydratase activity
H1D28_RS27525	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H1D28_RS27530	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H1D28_RS27540	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H1D28_RS27545	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H1D28_RS27550	COG3118	belongs to the thioredoxin family
H1D28_RS27575	COG1811	Na channel or pump
H1D28_RS27585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H1D28_RS27590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H1D28_RS27600	COG0583	DNA-binding transcription factor activity
H1D28_RS27605	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H1D28_RS27620	COG3978	acetolactate synthase activity
H1D28_RS27640	COG3085	chromosome segregation
H1D28_RS27715	COG0583	DNA-binding transcription factor activity
H1D28_RS27730	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H1D28_RS27745	COG3443	Belongs to the bacterial solute-binding protein 9 family
H1D28_RS27750	COG2207	Transcriptional regulator
H1D28_RS27760	COG0371	Dehydrogenase
H1D28_RS27765	COG0697	spore germination
H1D28_RS27775	COG0583	DNA-binding transcription factor activity
H1D28_RS27785	COG0737	Belongs to the 5'-nucleotidase family
H1D28_RS27795	COG0527	aspartate kinase activity
H1D28_RS27795	COG0460	homoserine dehydrogenase
H1D28_RS27800	COG0626	cystathionine gamma-synthase activity
H1D28_RS27815	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H1D28_RS27820	COG1609	Transcriptional regulator
H1D28_RS27825	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H1D28_RS27840	COG1575	Belongs to the MenA family. Type 1 subfamily
H1D28_RS27860	COG3678	ATP-independent chaperone mediated protein folding
H1D28_RS27865	COG0745	RESPONSE REGULATOR receiver
H1D28_RS27870	COG2205	protein histidine kinase activity
H1D28_RS27875	COG2258	MOSC domain
H1D28_RS27880	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H1D28_RS27920	COG1129	ABC transporter
H1D28_RS27925	COG1172	Belongs to the binding-protein-dependent transport system permease family
H1D28_RS27930	COG1172	Belongs to the binding-protein-dependent transport system permease family
H1D28_RS27935	COG1454	alcohol dehydrogenase
H1D28_RS27945	COG2211	Major facilitator Superfamily
H1D28_RS28005	COG0205	6-phosphofructokinase activity
H1D28_RS28025	COG0437	4 iron, 4 sulfur cluster binding
H1D28_RS28030	COG2864	formate dehydrogenase
H1D28_RS28045	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H1D28_RS28055	COG0456	acetyltransferase
H1D28_RS28070	COG1011	Hydrolase
H1D28_RS28085	COG3852	Histidine kinase
H1D28_RS28100	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H1D28_RS28120	COG0204	Acyl-transferase
H1D28_RS28130	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H1D28_RS28135	COG3084	Protein conserved in bacteria
H1D28_RS28145	COG1763	Mo-molybdopterin cofactor biosynthetic process
H1D28_RS28170	COG2186	Transcriptional regulator
H1D28_RS28175	COG0477	Major facilitator Superfamily
H1D28_RS28180	COG1609	Transcriptional regulator
H1D28_RS28185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H1D28_RS28195	COG1172	Belongs to the binding-protein-dependent transport system permease family
H1D28_RS28200	COG1129	ABC transporter
H1D28_RS28230	COG1522	sequence-specific DNA binding
H1D28_RS28235	COG0716	FMN binding
H1D28_RS28250	COG3312	ion transport
H1D28_RS28300	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H1D28_RS28305	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H1D28_RS28310	COG0573	inorganic phosphate transmembrane transporter activity
H1D28_RS28315	COG0581	inorganic phosphate transmembrane transporter activity
H1D28_RS28320	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H1D28_RS28325	COG0704	Plays a role in the regulation of phosphate uptake
H1D28_RS28335	COG2382	esterase
H1D28_RS28340	COG0363	glucosamine-6-phosphate deaminase activity
H1D28_RS28345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H1D28_RS28350	COG2252	PERMEase
H1D28_RS28355	COG0431	NADPH-dependent FMN reductase
H1D28_RS28360	COG2091	lysine biosynthetic process via aminoadipic acid
H1D28_RS28380	COG0454	-acetyltransferase
H1D28_RS28425	COG0717	Belongs to the dCTP deaminase family
H1D28_RS28440	COG0582	viral genome integration into host DNA
H1D28_RS28455	COG0759	Could be involved in insertion of integral membrane proteins into the membrane