locus-tag	class	description
I5M59_RS00025	COG0456	acetyltransferase
I5M59_RS00035	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I5M59_RS00065	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I5M59_RS00120	COG0527	aspartate kinase activity
I5M59_RS00130	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I5M59_RS00140	COG0251	oxidation-reduction process
I5M59_RS00210	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I5M59_RS00220	COG0534	Mate efflux family protein
I5M59_RS00230	COG3237	CsbD-like
I5M59_RS00235	COG0735	belongs to the Fur family
I5M59_RS00245	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I5M59_RS00260	COG0305	Participates in initiation and elongation during chromosome replication
I5M59_RS00265	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I5M59_RS00280	COG0432	Pfam Uncharacterised protein family UPF0047
I5M59_RS00285	COG2315	Protein conserved in bacteria
I5M59_RS00300	COG0741	lytic transglycosylase activity
I5M59_RS00305	COG4771	TonB-dependent receptor
I5M59_RS00325	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I5M59_RS00335	COG0483	inositol monophosphate 1-phosphatase activity
I5M59_RS00340	COG1609	Transcriptional regulator
I5M59_RS00345	COG1234	tRNA 3'-trailer cleavage
I5M59_RS00375	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I5M59_RS00385	COG0789	Transcriptional regulator
I5M59_RS00390	COG0625	glutathione transferase activity
I5M59_RS00395	COG2252	PERMEase
I5M59_RS00400	COG0025	NhaP-type Na H and K H
I5M59_RS00405	COG0583	DNA-binding transcription factor activity
I5M59_RS00410	COG1380	Effector of murein hydrolase LrgA
I5M59_RS00415	COG1346	cytolysis
I5M59_RS00420	COG3539	Fimbrial protein
I5M59_RS00450	COG3162	membrane
I5M59_RS00455	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I5M59_RS00465	COG1301	dicarboxylic acid transport
I5M59_RS00470	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I5M59_RS00505	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M59_RS00510	COG1129	ABC transporter
I5M59_RS00515	COG0784	Response regulator, receiver
I5M59_RS00515	COG4191	Histidine kinase
I5M59_RS00525	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I5M59_RS00535	COG3454	Phosphonate metabolism
I5M59_RS00540	COG4778	phosphonate C-P lyase system protein PhnL
I5M59_RS00545	COG4107	phosphonate C-P lyase system protein PhnK
I5M59_RS00550	COG3627	carbon phosphorus lyase activity
I5M59_RS00555	COG3626	phosphonate metabolism
I5M59_RS00560	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I5M59_RS00565	COG3624	Phosphonate C-P lyase system protein PhnG
I5M59_RS00570	COG2188	Transcriptional regulator
I5M59_RS00575	COG2764	glyoxalase bleomycin resistance protein dioxygenase
I5M59_RS00580	COG2824	Alkylphosphonate utilization operon protein PhnA
I5M59_RS00590	COG2169	Transcriptional regulator
I5M59_RS00595	COG1486	melibiose metabolic process
I5M59_RS00635	COG0861	Integral membrane protein TerC family
I5M59_RS00650	COG1215	transferase activity, transferring glycosyl groups
I5M59_RS00655	COG0726	polysaccharide deacetylase
I5M59_RS00655	COG1649	PFAM Uncharacterised BCR, COG1649
I5M59_RS00660	COG0457	Tetratricopeptide repeat
I5M59_RS00690	COG1309	transcriptional regulator
I5M59_RS00705	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I5M59_RS00710	COG1027	Aspartate ammonia-lyase
I5M59_RS00715	COG3030	protein affecting phage T7 exclusion by the F plasmid
I5M59_RS00720	COG0531	amino acid
I5M59_RS00750	COG3539	Fimbrial protein
I5M59_RS00755	COG3188	usher protein
I5M59_RS00795	COG1509	lysine 2,3-aminomutase activity
I5M59_RS00810	COG5510	response to toxic substance
I5M59_RS00815	COG2076	Multidrug Resistance protein
I5M59_RS00835	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I5M59_RS00840	COG1053	succinate dehydrogenase
I5M59_RS00855	COG3264	Mechanosensitive ion channel
I5M59_RS00855	COG1511	domain protein
I5M59_RS00875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M59_RS00895	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I5M59_RS00900	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I5M59_RS00900	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I5M59_RS00905	COG0802	atpase or kinase
I5M59_RS00910	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5M59_RS00930	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I5M59_RS00935	COG0330	HflC and HflK could
I5M59_RS00940	COG0330	HflC and HflK could
I5M59_RS00950	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I5M59_RS00965	COG0557	exoribonuclease II activity
I5M59_RS00970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I5M59_RS00975	COG1960	acyl-CoA dehydrogenase activity
I5M59_RS00985	COG3650	response to hydrogen peroxide
I5M59_RS00990	COG1073	alpha beta
I5M59_RS01050	COG2965	DNA replication, synthesis of RNA primer
I5M59_RS01055	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I5M59_RS01065	COG3061	Opacity-associated protein A
I5M59_RS01070	COG0545	Peptidyl-prolyl cis-trans isomerase
I5M59_RS01075	COG1113	amino acid transport
I5M59_RS01085	COG0697	spore germination
I5M59_RS01095	COG0702	epimerase
I5M59_RS01100	COG1733	regulation of RNA biosynthetic process
I5M59_RS01115	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I5M59_RS01140	COG1253	flavin adenine dinucleotide binding
I5M59_RS01150	COG0729	surface antigen
I5M59_RS01155	COG2911	Protein conserved in bacteria
I5M59_RS01160	COG2105	PFAM AIG2 family protein
I5M59_RS01180	COG1879	ABC-type sugar transport system periplasmic component
I5M59_RS01185	COG1129	ABC transporter
I5M59_RS01190	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M59_RS01195	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M59_RS01205	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I5M59_RS01230	COG0312	modulator of DNA gyrase
I5M59_RS01270	COG3964	amidohydrolase
I5M59_RS01285	COG2706	6-phosphogluconolactonase activity
I5M59_RS01290	COG3711	transcriptional antiterminator
I5M59_RS01290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M59_RS01295	COG3077	Addiction module antitoxin, RelB DinJ family
I5M59_RS01300	COG2026	Addiction module toxin, RelE StbE family
I5M59_RS01305	COG0602	queuosine metabolic process
I5M59_RS01335	COG1486	melibiose metabolic process
I5M59_RS01340	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M59_RS01345	COG0366	Alpha amylase catalytic
I5M59_RS01350	COG1263	PTS System
I5M59_RS01350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5M59_RS01385	COG2731	YhcH YjgK YiaL family protein
I5M59_RS01390	COG2222	sugar isomerase
I5M59_RS01405	COG1288	antiporter activity
I5M59_RS01410	COG2188	Transcriptional regulator
I5M59_RS01435	COG0525	valine-tRNA ligase activity
I5M59_RS01440	COG2927	DNA polymerase III (CHI subunit)
I5M59_RS01450	COG0795	lipopolysaccharide-transporting ATPase activity
I5M59_RS01455	COG0795	lipopolysaccharide-transporting ATPase activity
I5M59_RS01460	COG0433	COG0433 Predicted ATPase
I5M59_RS01475	COG3718	enzyme involved in inositol metabolism
I5M59_RS01480	COG1737	Transcriptional regulator
I5M59_RS01480	COG0837	glucose binding
I5M59_RS01485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5M59_RS01490	COG3962	Belongs to the TPP enzyme family
I5M59_RS01500	COG1082	Xylose isomerase domain protein TIM barrel
I5M59_RS01515	COG3842	ATPase activity
I5M59_RS01520	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I5M59_RS01525	COG0395	ABC-type sugar transport system, permease component
I5M59_RS01530	COG1175	transmembrane transport
I5M59_RS01535	COG1064	alcohol dehydrogenase
I5M59_RS01540	COG0659	secondary active sulfate transmembrane transporter activity
I5M59_RS01545	COG0288	reversible hydration of carbon dioxide
I5M59_RS01555	COG0582	viral genome integration into host DNA
I5M59_RS01565	COG0732	type I restriction modification DNA specificity domain
I5M59_RS01575	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I5M59_RS01595	COG3596	GTP binding
I5M59_RS01615	COG2003	Belongs to the UPF0758 family
I5M59_RS01660	COG3507	Belongs to the glycosyl hydrolase 43 family
I5M59_RS01665	COG2211	Major facilitator Superfamily
I5M59_RS01670	COG2115	Belongs to the xylose isomerase family
I5M59_RS01675	COG4580	involved in the transport of maltose and maltodextrins
I5M59_RS01680	COG3272	Protein of unknown function (DUF1722)
I5M59_RS01700	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I5M59_RS01715	COG0300	oxidoreductase activity
I5M59_RS01720	COG3631	Ketosteroid isomerase-related protein
I5M59_RS01725	COG0789	Transcriptional regulator
I5M59_RS01730	COG3040	lipid binding
I5M59_RS01740	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5M59_RS01745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M59_RS01750	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M59_RS01755	COG1538	Outer membrane efflux protein
I5M59_RS01760	COG0745	RESPONSE REGULATOR receiver
I5M59_RS01765	COG5002	protein histidine kinase activity
I5M59_RS01780	COG2850	peptidyl-arginine hydroxylation
I5M59_RS01810	COG0842	Transport permease protein
I5M59_RS01815	COG1129	ABC transporter
I5M59_RS01815	COG0842	Transport permease protein
I5M59_RS01820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M59_RS01830	COG1879	ABC-type sugar transport system periplasmic component
I5M59_RS01835	COG1129	ABC transporter
I5M59_RS01840	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M59_RS01850	COG2249	NAD(P)H dehydrogenase (quinone) activity
I5M59_RS01855	COG0583	DNA-binding transcription factor activity
I5M59_RS01870	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I5M59_RS01875	COG0732	type I restriction modification DNA specificity domain
I5M59_RS01880	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I5M59_RS01885	COG1715	Restriction endonuclease
I5M59_RS01890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5M59_RS01895	COG5457	Domain of unknown function (DUF1127)
I5M59_RS01905	COG1566	PFAM secretion protein HlyD family protein
I5M59_RS01920	COG1924	4 iron, 4 sulfur cluster binding
I5M59_RS01925	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I5M59_RS01940	COG2733	membrane
I5M59_RS01950	COG2207	Transcriptional regulator
I5M59_RS01950	COG1917	Cupin 2, conserved barrel domain protein
I5M59_RS01955	COG5464	transposase or invertase
I5M59_RS01960	COG1012	belongs to the aldehyde dehydrogenase family
I5M59_RS01975	COG0523	cobalamin synthesis protein
I5M59_RS01980	COG2879	small protein
I5M59_RS01985	COG1966	Carbon starvation protein
I5M59_RS02000	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I5M59_RS02005	COG2368	4-hydroxyphenylacetate
I5M59_RS02025	COG3971	2-oxopent-4-enoate hydratase activity
I5M59_RS02035	COG3384	dioxygenase
I5M59_RS02040	COG1012	belongs to the aldehyde dehydrogenase family
I5M59_RS02050	COG0179	Fumarylacetoacetate (FAA) hydrolase
I5M59_RS02060	COG1846	Transcriptional regulator
I5M59_RS02090	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I5M59_RS02105	COG3734	2-keto-3-deoxy-galactonokinase
I5M59_RS02110	COG0800	Aldolase
I5M59_RS02115	COG1737	Transcriptional regulator
I5M59_RS02125	COG1214	PFAM Peptidase M22, glycoprotease
I5M59_RS02125	COG0456	acetyltransferase
I5M59_RS02130	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I5M59_RS02130	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I5M59_RS02145	COG3715	PTS system
I5M59_RS02150	COG3716	PTS system mannose fructose sorbose family IID component
I5M59_RS02155	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I5M59_RS02165	COG5464	transposase or invertase
I5M59_RS02180	COG1484	DNA-dependent DNA replication
I5M59_RS02195	COG2966	Psort location CytoplasmicMembrane, score
I5M59_RS02210	COG2197	response regulator
I5M59_RS02215	COG2197	response regulator
I5M59_RS02220	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I5M59_RS02225	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M59_RS02225	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M59_RS02230	COG4114	ferric iron reductase
I5M59_RS02235	COG3706	GGDEF domain
I5M59_RS02270	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I5M59_RS02275	COG0456	acetyltransferase
I5M59_RS02280	COG1011	Hydrolase
I5M59_RS02290	COG2823	Periplasmic or secreted lipoprotein
I5M59_RS02300	COG4667	esterase of the alpha-beta hydrolase superfamily
I5M59_RS02305	COG0084	hydrolase, TatD family'
I5M59_RS02310	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I5M59_RS02340	COG3726	membrane protein affecting hemolysin expression
I5M59_RS02345	COG0560	Phosphoserine phosphatase
I5M59_RS02350	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I5M59_RS02360	COG0488	(ABC) transporter
I5M59_RS02365	COG0741	lytic transglycosylase activity
I5M59_RS02385	COG3708	Transcriptional regulator
I5M59_RS02385	COG2207	Transcriptional regulator
I5M59_RS02390	COG3045	CreA protein
I5M59_RS02395	COG0745	RESPONSE REGULATOR receiver
I5M59_RS02400	COG2205	protein histidine kinase activity
I5M59_RS02405	COG4452	Inner membrane protein CreD
I5M59_RS02410	COG0745	RESPONSE REGULATOR receiver
I5M59_RS02420	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I5M59_RS02430	COG0460	homoserine dehydrogenase
I5M59_RS02430	COG0527	aspartate kinase activity
I5M59_RS02440	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I5M59_RS02455	COG1115	amino acid carrier protein
I5M59_RS02460	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I5M59_RS02465	COG0521	Mo-molybdopterin cofactor biosynthetic process
I5M59_RS02470	COG0477	Major facilitator Superfamily
I5M59_RS02475	COG1584	GPR1 FUN34 yaaH family protein
I5M59_RS02480	COG4735	regulation of single-species biofilm formation
I5M59_RS02505	COG0583	DNA-binding transcription factor activity
I5M59_RS02515	COG0196	riboflavin kinase activity
I5M59_RS02530	COG1047	Peptidyl-prolyl cis-trans
I5M59_RS02555	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I5M59_RS02620	COG0505	Belongs to the CarA family
I5M59_RS02665	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I5M59_RS02675	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I5M59_RS02680	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I5M59_RS02695	COG3493	citrate carrier protein
I5M59_RS02705	COG0564	pseudouridine synthase activity
I5M59_RS02715	COG0417	DNA replication proofreading
I5M59_RS02720	COG0235	Class ii aldolase
I5M59_RS02740	COG0586	Pfam SNARE associated Golgi protein
I5M59_RS02750	COG1178	ABC-type Fe3 transport system permease component
I5M59_RS02770	COG2814	Major facilitator Superfamily
I5M59_RS02775	COG2271	Major facilitator Superfamily
I5M59_RS02780	COG0583	DNA-binding transcription factor activity
I5M59_RS02790	COG0738	Major facilitator superfamily
I5M59_RS02835	COG0028	Belongs to the TPP enzyme family
I5M59_RS02845	COG1609	Transcriptional regulator
I5M59_RS02865	COG0768	penicillin binding
I5M59_RS02870	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I5M59_RS02875	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I5M59_RS02890	COG0772	Belongs to the SEDS family
I5M59_RS02915	COG0849	cell division
I5M59_RS02920	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I5M59_RS02940	COG0494	nUDIX hydrolase
I5M59_RS02965	COG1459	type II secretion system
I5M59_RS02975	COG4969	Belongs to the N-Me-Phe pilin family
I5M59_RS02985	COG3023	N-Acetylmuramoyl-L-alanine amidase
I5M59_RS02990	COG3725	Membrane protein required for beta-lactamase induction
I5M59_RS02995	COG3940	Belongs to the glycosyl hydrolase 43 family
I5M59_RS03000	COG2211	Major facilitator Superfamily
I5M59_RS03005	COG1113	amino acid transport
I5M59_RS03010	COG2186	Transcriptional regulator
I5M59_RS03015	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I5M59_RS03020	COG0508	dehydrogenase complex catalyzes the overall conversion of
I5M59_RS03025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5M59_RS03040	COG3064	Membrane
I5M59_RS03085	COG2132	Multicopper oxidase
I5M59_RS03090	COG4993	Dehydrogenase
I5M59_RS03105	COG0288	reversible hydration of carbon dioxide
I5M59_RS03110	COG1131	(ABC) transporter
I5M59_RS03115	COG0842	Transport permease protein
I5M59_RS03120	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M59_RS03125	COG0726	polysaccharide deacetylase
I5M59_RS03145	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I5M59_RS03150	COG0617	tRNA 3'-terminal CCA addition
I5M59_RS03170	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I5M59_RS03175	COG1643	Atp-dependent helicase
I5M59_RS03270	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I5M59_RS03275	COG4774	siderophore transport
I5M59_RS03280	COG1120	ATPase activity
I5M59_RS03285	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I5M59_RS03290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M59_RS03310	COG2860	membrane
I5M59_RS03330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5M59_RS03335	COG3835	regulator
I5M59_RS03350	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I5M59_RS03355	COG0024	Methionine aminopeptidase
I5M59_RS03380	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I5M59_RS03390	COG0575	Belongs to the CDS family
I5M59_RS03395	COG0750	zinc metalloprotease
I5M59_RS03405	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I5M59_RS03435	COG0587	DNA-directed DNA polymerase activity
I5M59_RS03445	COG1982	Orn Lys Arg decarboxylase major
I5M59_RS03450	COG0346	lactoylglutathione lyase activity
I5M59_RS03460	COG4568	rho-dependent transcription termination
I5M59_RS03475	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I5M59_RS03480	COG3015	lipoprotein NlpE involved in copper resistance
I5M59_RS03485	COG0791	NLP P60 protein
I5M59_RS03495	COG1720	tRNA m6t6A37 methyltransferase activity
I5M59_RS03505	COG1464	Belongs to the NlpA lipoprotein family
I5M59_RS03510	COG2011	ABC-type metal ion transport system permease component
I5M59_RS03520	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I5M59_RS03555	COG0656	L-ascorbic acid biosynthetic process
I5M59_RS03560	COG0583	DNA-binding transcription factor activity
I5M59_RS03565	COG2814	Major facilitator Superfamily
I5M59_RS03575	COG2226	methyltransferase
I5M59_RS03580	COG0741	lytic transglycosylase activity
I5M59_RS03580	COG1388	LysM domain
I5M59_RS03590	COG2226	methyltransferase
I5M59_RS03600	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I5M59_RS03610	COG0583	DNA-binding transcription factor activity
I5M59_RS03620	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I5M59_RS03625	COG1960	acyl-CoA dehydrogenase activity
I5M59_RS03635	COG0121	glutamine amidotransferase
I5M59_RS03640	COG3034	peptidoglycan biosynthetic process
I5M59_RS03655	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I5M59_RS03660	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I5M59_RS03675	COG2991	Protein conserved in bacteria
I5M59_RS03690	COG0454	-acetyltransferase
I5M59_RS03695	COG2195	Cleaves the N-terminal amino acid of tripeptides
I5M59_RS03715	COG1802	Transcriptional regulator
I5M59_RS03720	COG1113	amino acid transport
I5M59_RS03725	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I5M59_RS03730	COG1012	belongs to the aldehyde dehydrogenase family
I5M59_RS03735	COG0579	oxidoreductase
I5M59_RS03750	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I5M59_RS03755	COG0625	glutathione transferase activity
I5M59_RS03760	COG3775	system Galactitol-specific IIC component
I5M59_RS03765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5M59_RS03770	COG1028	Short-chain dehydrogenase reductase Sdr
I5M59_RS03775	COG1070	Carbohydrate kinase
I5M59_RS03795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5M59_RS03800	COG0508	dehydrogenase complex catalyzes the overall conversion of
I5M59_RS03805	COG0022	dehydrogenase e1 component
I5M59_RS03810	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I5M59_RS03815	COG2909	trisaccharide binding
I5M59_RS03840	COG2003	Belongs to the UPF0758 family
I5M59_RS03870	COG2378	regulation of single-species biofilm formation
I5M59_RS03880	COG3596	GTP binding
I5M59_RS03940	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I5M59_RS03950	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I5M59_RS03965	COG0582	viral genome integration into host DNA
I5M59_RS03990	COG0791	NLP P60 protein
I5M59_RS04010	COG3639	organic phosphonate transmembrane transporter activity
I5M59_RS04020	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I5M59_RS04045	COG3188	usher protein
I5M59_RS04060	COG0765	amino acid transport
I5M59_RS04065	COG4597	amino acid ABC transporter
I5M59_RS04070	COG1126	abc transporter atp-binding protein
I5M59_RS04075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M59_RS04115	COG4302	ethanolamine ammonia-lyase activity
I5M59_RS04120	COG4303	Ethanolamine ammonia lyase large subunit
I5M59_RS04135	COG0833	amino acid
I5M59_RS04140	COG2040	homocysteine
I5M59_RS04145	COG4521	taurine ABC transporter
I5M59_RS04150	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I5M59_RS04155	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5M59_RS04160	COG2175	clavaminate synthase activity
I5M59_RS04170	COG1943	Transposase
I5M59_RS04175	COG0113	porphobilinogen synthase activity
I5M59_RS04180	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I5M59_RS04185	COG1335	isochorismatase
I5M59_RS04190	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I5M59_RS04230	COG1785	Belongs to the alkaline phosphatase family
I5M59_RS04240	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I5M59_RS04250	COG3416	Protein conserved in bacteria
I5M59_RS04255	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I5M59_RS04265	COG4126	flavin adenine dinucleotide binding
I5M59_RS04280	COG1940	carbohydrate kinase activity
I5M59_RS04285	COG0419	ATPase involved in DNA repair
I5M59_RS04290	COG0420	3'-5' exonuclease activity
I5M59_RS04315	COG0366	Alpha amylase catalytic
I5M59_RS04320	COG0583	DNA-binding transcription factor activity
I5M59_RS04325	COG1335	isochorismatase
I5M59_RS04335	COG1228	amidohydrolase
I5M59_RS04345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5M59_RS04360	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M59_RS04370	COG0450	alkyl hydroperoxide reductase
I5M59_RS04395	COG1862	Preprotein translocase
I5M59_RS04400	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I5M59_RS04405	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I5M59_RS04425	COG4238	major outer membrane lipoprotein
I5M59_RS04435	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I5M59_RS04435	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I5M59_RS04455	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I5M59_RS04460	COG0667	Aldo Keto reductase
I5M59_RS04470	COG0142	geranyltranstransferase activity
I5M59_RS04490	COG0693	protein deglycase activity
I5M59_RS04495	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I5M59_RS04505	COG2814	Major facilitator Superfamily
I5M59_RS04510	COG0673	inositol 2-dehydrogenase activity
I5M59_RS04525	COG1053	succinate dehydrogenase
I5M59_RS04535	COG1053	succinate dehydrogenase
I5M59_RS04540	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I5M59_RS04545	COG1414	Transcriptional regulator
I5M59_RS04560	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I5M59_RS04565	COG1845	cytochrome c oxidase, subunit III
I5M59_RS04570	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I5M59_RS04575	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I5M59_RS04580	COG2223	nitrite transmembrane transporter activity
I5M59_RS04585	COG3056	Lipoprotein
I5M59_RS04590	COG0271	Belongs to the BolA IbaG family
I5M59_RS04610	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I5M59_RS04615	COG0776	regulation of translation
I5M59_RS04620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5M59_RS04625	COG1555	photosystem II stabilization
I5M59_RS04630	COG0824	Thioesterase
I5M59_RS04640	COG4533	DNA binding
I5M59_RS04655	COG1522	sequence-specific DNA binding
I5M59_RS04660	COG1132	(ABC) transporter
I5M59_RS04665	COG1132	(ABC) transporter
I5M59_RS04670	COG0347	Belongs to the P(II) protein family
I5M59_RS04675	COG0004	ammonium transporteR
I5M59_RS04680	COG1946	Acyl-CoA thioesterase
I5M59_RS04685	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I5M59_RS04690	COG3695	enzyme binding
I5M59_RS04720	COG2364	Membrane
I5M59_RS04735	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I5M59_RS04745	COG2182	Extracellular solute-binding protein
I5M59_RS04750	COG1175	transmembrane transport
I5M59_RS04755	COG3833	ABC-type maltose transport systems, permease component
I5M59_RS04760	COG3867	Arabinogalactan endo-beta-1,4-galactanase
I5M59_RS04765	COG1874	Beta-galactosidase
I5M59_RS04815	COG0110	maltose O-acetyltransferase activity
I5M59_RS04830	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5M59_RS04835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M59_RS04840	COG1309	transcriptional regulator
I5M59_RS04845	COG1196	nuclear chromosome segregation
I5M59_RS04845	COG3264	Mechanosensitive ion channel
I5M59_RS04850	COG5464	transposase or invertase
I5M59_RS04860	COG3923	Primosomal replication protein n
I5M59_RS04865	COG2832	Protein of unknown function (DUF454)
I5M59_RS04905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5M59_RS04910	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I5M59_RS04910	COG4651	solute:proton antiporter activity
I5M59_RS04915	COG2223	nitrite transmembrane transporter activity
I5M59_RS04925	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I5M59_RS04930	COG3735	TraB family
I5M59_RS04945	COG1585	Membrane protein implicated in regulation of membrane protease activity
I5M59_RS04950	COG0330	HflC and HflK could
I5M59_RS04955	COG4619	ABC transporter
I5M59_RS04960	COG0390	transport system, permease component
I5M59_RS04965	COG3118	belongs to the thioredoxin family
I5M59_RS04970	COG0300	oxidoreductase activity
I5M59_RS04975	COG2755	lipolytic protein G-D-S-L family
I5M59_RS04980	COG4181	ATPase activity
I5M59_RS04985	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I5M59_RS05005	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I5M59_RS05010	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I5M59_RS05025	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I5M59_RS05035	COG2501	S4 domain
I5M59_RS05085	COG3539	Fimbrial protein
I5M59_RS05090	COG3121	Chaperone
I5M59_RS05095	COG3188	usher protein
I5M59_RS05110	COG1560	Kdo2-lipid A biosynthetic process
I5M59_RS05120	COG3710	Transcriptional regulator
I5M59_RS05125	COG0531	amino acid
I5M59_RS05130	COG1982	Orn Lys Arg decarboxylase major
I5M59_RS05135	COG3104	oligopeptide transport
I5M59_RS05165	COG0673	inositol 2-dehydrogenase activity
I5M59_RS05180	COG1129	ABC transporter
I5M59_RS05185	COG4211	Belongs to the binding-protein-dependent transport system permease family
I5M59_RS05230	COG1566	PFAM secretion protein HlyD family protein
I5M59_RS05235	COG1120	ATPase activity
I5M59_RS05240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M59_RS05270	COG1473	amidohydrolase
I5M59_RS05275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M59_RS05280	COG0667	Aldo Keto reductase
I5M59_RS05325	COG0531	amino acid
I5M59_RS05335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5M59_RS05340	COG1012	belongs to the aldehyde dehydrogenase family
I5M59_RS05355	COG1113	amino acid transport
I5M59_RS05360	COG2211	Major facilitator Superfamily
I5M59_RS05370	COG0673	inositol 2-dehydrogenase activity
I5M59_RS05380	COG1609	Transcriptional regulator
I5M59_RS05385	COG0668	transmembrane transport
I5M59_RS05390	COG0477	Major facilitator Superfamily
I5M59_RS05405	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I5M59_RS05405	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I5M59_RS05410	COG2222	sugar isomerase
I5M59_RS05415	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I5M59_RS05420	COG3716	PTS system mannose fructose sorbose family IID component
I5M59_RS05430	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5M59_RS05440	COG0778	Nitroreductase
I5M59_RS05445	COG2315	Protein conserved in bacteria
I5M59_RS05485	COG3698	Phosphodiester glycosidase
I5M59_RS05495	COG4166	transmembrane transport
I5M59_RS05505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5M59_RS05510	COG4608	Belongs to the ABC transporter superfamily
I5M59_RS05525	COG0697	spore germination
I5M59_RS05540	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I5M59_RS05545	COG0765	amino acid transport
I5M59_RS05550	COG4215	(ABC) transporter
I5M59_RS05560	COG4221	oxidoreductase activity
I5M59_RS05565	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I5M59_RS05570	COG4608	Belongs to the ABC transporter superfamily
I5M59_RS05575	COG0444	Belongs to the ABC transporter superfamily
I5M59_RS05580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5M59_RS05585	COG0601	transmembrane transport
I5M59_RS05590	COG0747	negative chemotaxis
I5M59_RS05615	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I5M59_RS05625	COG0668	transmembrane transport
I5M59_RS05630	COG0583	DNA-binding transcription factor activity
I5M59_RS05640	COG1028	Short-chain dehydrogenase reductase Sdr
I5M59_RS05650	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M59_RS05655	COG1129	ABC transporter
I5M59_RS05665	COG1879	ABC-type sugar transport system periplasmic component
I5M59_RS05670	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I5M59_RS05675	COG2390	Transcriptional regulator
I5M59_RS05680	COG3959	Transketolase, thiamine diphosphate binding domain
I5M59_RS05685	COG3958	Transketolase
I5M59_RS05690	COG2977	Belongs to the P-Pant transferase superfamily
I5M59_RS05695	COG4771	TonB-dependent receptor
I5M59_RS05700	COG2382	esterase
I5M59_RS05705	COG3251	PFAM MbtH domain protein
I5M59_RS05710	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I5M59_RS05710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I5M59_RS05715	COG1120	ATPase activity
I5M59_RS05720	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M59_RS05725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M59_RS05735	COG4592	Periplasmic binding protein
I5M59_RS05740	COG1169	isochorismate synthase
I5M59_RS05745	COG1021	2,3-dihydroxybenzoate-AMP ligase
I5M59_RS05750	COG3433	isochorismatase activity
I5M59_RS05750	COG1535	isochorismatase
I5M59_RS05755	COG1028	Short-chain dehydrogenase reductase Sdr
I5M59_RS05765	COG1966	Carbon starvation protein
I5M59_RS05770	COG2879	small protein
I5M59_RS05775	COG2211	Major facilitator Superfamily
I5M59_RS05790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5M59_RS05800	COG2188	Transcriptional regulator
I5M59_RS05810	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I5M59_RS05835	COG1028	Short-chain dehydrogenase reductase Sdr
I5M59_RS05840	COG0371	Dehydrogenase
I5M59_RS05845	COG1129	ABC transporter
I5M59_RS05850	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M59_RS05880	COG2271	Major facilitator Superfamily
I5M59_RS05885	COG0483	inositol monophosphate 1-phosphatase activity
I5M59_RS05895	COG0402	S-adenosylhomocysteine deaminase activity
I5M59_RS05905	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I5M59_RS05920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5M59_RS05930	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M59_RS05935	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M59_RS05940	COG1129	ABC transporter
I5M59_RS05965	COG0436	Aminotransferase
I5M59_RS05970	COG1475	DNA binding
I5M59_RS05975	COG3969	phosphoadenosine phosphosulfate
I5M59_RS05980	COG0583	DNA-binding transcription factor activity
I5M59_RS05985	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I5M59_RS06005	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I5M59_RS06010	COG3719	Belongs to the RNase T2 family
I5M59_RS06015	COG3069	C4-dicarboxylate transmembrane transporter activity
I5M59_RS06035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I5M59_RS06050	COG0583	DNA-binding transcription factor activity
I5M59_RS06065	COG1686	Belongs to the peptidase S11 family
I5M59_RS06070	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I5M59_RS06075	COG0772	Belongs to the SEDS family
I5M59_RS06080	COG0768	penicillin binding
I5M59_RS06090	COG0799	negative regulation of ribosome biogenesis
I5M59_RS06105	COG1466	dna polymerase III delta subunit
I5M59_RS06120	COG2888	peptidyl-tyrosine sulfation
I5M59_RS06135	COG1126	abc transporter atp-binding protein
I5M59_RS06140	COG0765	amino acid transport
I5M59_RS06145	COG0765	amino acid transport
I5M59_RS06170	COG1702	phosphate starvation-inducible protein PhoH
I5M59_RS06180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5M59_RS06220	COG0367	asparagine synthase
I5M59_RS06225	COG0647	UMP catabolic process
I5M59_RS06230	COG1846	Transcriptional regulator
I5M59_RS06230	COG1940	carbohydrate kinase activity
I5M59_RS06235	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I5M59_RS06275	COG0735	belongs to the Fur family
I5M59_RS06290	COG0596	Alpha beta hydrolase
I5M59_RS06300	COG0033	Phosphoglucomutase
I5M59_RS06310	COG0745	RESPONSE REGULATOR receiver
I5M59_RS06315	COG2205	protein histidine kinase activity
I5M59_RS06345	COG0415	Belongs to the DNA photolyase family
I5M59_RS06360	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I5M59_RS06365	COG1984	allophanate hydrolase subunit 2
I5M59_RS06400	COG2009	succinate dehydrogenase
I5M59_RS06405	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I5M59_RS06410	COG1053	succinate dehydrogenase
I5M59_RS06415	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I5M59_RS06420	COG0567	Dehydrogenase, E1 component
I5M59_RS06425	COG0508	dehydrogenase complex catalyzes the overall conversion of
I5M59_RS06435	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I5M59_RS06440	COG1271	oxidase subunit
I5M59_RS06445	COG1294	oxidase, subunit
I5M59_RS06450	COG4890	Cyd operon protein YbgT
I5M59_RS06455	COG3790	cyd operon protein YbgE
I5M59_RS06460	COG0824	Thioesterase
I5M59_RS06465	COG0811	peptide transport
I5M59_RS06470	COG0848	biopolymer transport protein
I5M59_RS06475	COG3064	Membrane
I5M59_RS06485	COG2885	chlorophyll binding
I5M59_RS06490	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I5M59_RS06535	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I5M59_RS06540	COG3201	nicotinamide mononucleotide transporter
I5M59_RS06555	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I5M59_RS06565	COG2017	converts alpha-aldose to the beta-anomer
I5M59_RS06575	COG1085	galactose-1-phosphate uridylyltransferase
I5M59_RS06585	COG1119	ATPase activity
I5M59_RS06590	COG2005	Transcriptional regulator
I5M59_RS06590	COG3585	molybdate ion transport
I5M59_RS06600	COG0725	ABC transporter, periplasmic molybdate-binding protein
I5M59_RS06605	COG4149	molybdate abc transporter
I5M59_RS06615	COG0561	phosphatase activity
I5M59_RS06640	COG2200	EAL domain
I5M59_RS06645	COG0789	Transcriptional regulator
I5M59_RS06680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M59_RS06685	COG0589	response to stress
I5M59_RS06695	COG4677	pectinesterase activity
I5M59_RS06735	COG1881	PFAM PEBP family protein
I5M59_RS06740	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I5M59_RS06755	COG2226	methyltransferase
I5M59_RS06780	COG0642	Histidine kinase
I5M59_RS06785	COG0745	RESPONSE REGULATOR receiver
I5M59_RS06805	COG0521	Mo-molybdopterin cofactor biosynthetic process
I5M59_RS06815	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I5M59_RS06820	COG0314	molybdopterin synthase activity
I5M59_RS06825	COG0670	Belongs to the BI1 family
I5M59_RS06830	COG0392	lysyltransferase activity
I5M59_RS06835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5M59_RS06840	COG3568	Endonuclease Exonuclease Phosphatase
I5M59_RS06850	COG0842	Transport permease protein
I5M59_RS06855	COG0842	Transport permease protein
I5M59_RS06860	COG1131	(ABC) transporter
I5M59_RS06865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M59_RS06870	COG1309	transcriptional regulator
I5M59_RS06875	COG0583	DNA-binding transcription factor activity
I5M59_RS06885	COG2271	Major facilitator Superfamily
I5M59_RS06890	COG1028	Short-chain dehydrogenase reductase Sdr
I5M59_RS06895	COG3959	Transketolase, thiamine diphosphate binding domain
I5M59_RS06900	COG3958	Transketolase
I5M59_RS06905	COG0513	Belongs to the DEAD box helicase family
I5M59_RS06910	COG1199	ATP-dependent helicase activity
I5M59_RS06915	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I5M59_RS06925	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I5M59_RS06935	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I5M59_RS06945	COG0668	transmembrane transport
I5M59_RS06950	COG1126	abc transporter atp-binding protein
I5M59_RS06955	COG0765	amino acid transport
I5M59_RS06960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M59_RS06975	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I5M59_RS06980	COG2194	sulfuric ester hydrolase activity
I5M59_RS06995	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I5M59_RS07000	COG2723	6-phospho-beta-galactosidase activity
I5M59_RS07005	COG2188	Transcriptional regulator
I5M59_RS07010	COG1376	ErfK ybiS ycfS ynhG family protein
I5M59_RS07015	COG2365	Tyrosine phosphatase family
I5M59_RS07020	COG0488	(ABC) transporter
I5M59_RS07030	COG2271	Major facilitator Superfamily
I5M59_RS07035	COG1609	Transcriptional regulator
I5M59_RS07045	COG0561	phosphatase activity
I5M59_RS07050	COG1882	Formate acetyltransferase
I5M59_RS07055	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I5M59_RS07060	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I5M59_RS07065	COG0303	'Molybdopterin
I5M59_RS07075	COG4172	Belongs to the ABC transporter superfamily
I5M59_RS07080	COG0747	negative chemotaxis
I5M59_RS07100	COG2223	nitrite transmembrane transporter activity
I5M59_RS07110	COG2133	pyrroloquinoline quinone binding
I5M59_RS07115	COG0625	glutathione transferase activity
I5M59_RS07125	COG1686	Belongs to the peptidase S11 family
I5M59_RS07130	COG1349	DNA-binding transcription factor activity
I5M59_RS07135	COG0671	phosphoesterase, PA-phosphatase related
I5M59_RS07140	COG2814	Major facilitator Superfamily
I5M59_RS07145	COG0561	phosphatase activity
I5M59_RS07150	COG0738	Major facilitator superfamily
I5M59_RS07155	COG3226	Transcriptional regulator
I5M59_RS07180	COG0778	Nitroreductase
I5M59_RS07195	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I5M59_RS07200	COG3842	ATPase activity
I5M59_RS07205	COG1176	ABC-type spermidine putrescine transport system, permease component I
I5M59_RS07210	COG1177	transmembrane transport
I5M59_RS07225	COG0745	RESPONSE REGULATOR receiver
I5M59_RS07230	COG5002	protein histidine kinase activity
I5M59_RS07235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M59_RS07240	COG4160	amino acid transport
I5M59_RS07245	COG4215	(ABC) transporter
I5M59_RS07250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M59_RS07255	COG1126	abc transporter atp-binding protein
I5M59_RS07265	COG4251	negative regulation of phosphorylation
I5M59_RS07265	COG3706	GGDEF domain
I5M59_RS07265	COG2203	Gaf domain
I5M59_RS07265	COG5001	Diguanylate cyclase
I5M59_RS07270	COG3023	N-Acetylmuramoyl-L-alanine amidase
I5M59_RS07275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I5M59_RS07280	COG0702	epimerase
I5M59_RS07285	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I5M59_RS07290	COG0028	Belongs to the TPP enzyme family
I5M59_RS07300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5M59_RS07310	COG2431	L-lysine efflux transmembrane transporter activity
I5M59_RS07320	COG3593	DNA synthesis involved in DNA repair
I5M59_RS07325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M59_RS07335	COG1278	Cold shock
I5M59_RS07345	COG0542	response to heat
I5M59_RS07360	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I5M59_RS07365	COG4988	ABC transporter
I5M59_RS07370	COG0492	ferredoxin-NADP+ reductase activity
I5M59_RS07380	COG1674	ftsk spoiiie
I5M59_RS07380	COG1178	ABC-type Fe3 transport system permease component
I5M59_RS07390	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I5M59_RS07400	COG0243	molybdopterin cofactor binding
I5M59_RS07405	COG0437	4 iron, 4 sulfur cluster binding
I5M59_RS07410	COG3302	dmso reductase anchor subunit
I5M59_RS07415	COG0477	Major facilitator Superfamily
I5M59_RS07420	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I5M59_RS07425	COG1882	Formate acetyltransferase
I5M59_RS07430	COG2116	formate transmembrane transporter activity
I5M59_RS07435	COG1944	ATP diphosphatase activity
I5M59_RS07440	COG2323	membrane
I5M59_RS07460	COG0539	negative regulation of cytoplasmic translation
I5M59_RS07470	COG2333	competence protein COMEC
I5M59_RS07470	COG0658	competence protein
I5M59_RS07485	COG3214	Protein conserved in bacteria
I5M59_RS07500	COG3173	Aminoglycoside phosphotransferase
I5M59_RS07505	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I5M59_RS07510	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I5M59_RS07520	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I5M59_RS07530	COG2989	Protein conserved in bacteria
I5M59_RS07535	COG3108	Peptidase M15
I5M59_RS07540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5M59_RS07545	COG1448	Aminotransferase
I5M59_RS07550	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I5M59_RS07570	COG0814	amino acid
I5M59_RS07580	COG1473	amidohydrolase
I5M59_RS07590	COG0308	aminopeptidase N
I5M59_RS07600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5M59_RS07605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5M59_RS07610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5M59_RS07615	COG0431	NADPH-dependent FMN reductase
I5M59_RS07630	COG3217	Mosc domain protein beta barrel domain protein
I5M59_RS07630	COG0633	Ferredoxin
I5M59_RS07640	COG0488	(ABC) transporter
I5M59_RS07645	COG2995	paraquat-inducible protein a
I5M59_RS07650	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I5M59_RS07650	COG3008	intermembrane lipid transfer
I5M59_RS07655	COG3009	Protein conserved in bacteria
I5M59_RS07660	COG3130	regulation of translation
I5M59_RS07670	COG1067	ATP-dependent peptidase activity
I5M59_RS07690	COG3070	regulator of competence-specific genes
I5M59_RS07695	COG1289	transmembrane transporter activity
I5M59_RS07700	COG3304	Inner membrane component domain
I5M59_RS07705	COG0210	DNA helicase
I5M59_RS07715	COG1832	CoA-binding protein
I5M59_RS07730	COG1881	PFAM PEBP family protein
I5M59_RS07735	COG2207	Transcriptional regulator
I5M59_RS07750	COG0670	Belongs to the BI1 family
I5M59_RS07775	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5M59_RS07780	COG1012	belongs to the aldehyde dehydrogenase family
I5M59_RS07785	COG4638	Rieske (2fe-2S)
I5M59_RS07790	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I5M59_RS07795	COG0473	3-isopropylmalate dehydrogenase activity
I5M59_RS07800	COG0583	DNA-binding transcription factor activity
I5M59_RS07805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5M59_RS07810	COG1012	belongs to the aldehyde dehydrogenase family
I5M59_RS07815	COG1396	sequence-specific DNA binding
I5M59_RS07815	COG1917	Cupin 2, conserved barrel domain protein
I5M59_RS07820	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I5M59_RS07825	COG0174	glutamine synthetase
I5M59_RS07830	COG0531	amino acid
I5M59_RS07845	COG1028	Short-chain dehydrogenase reductase Sdr
I5M59_RS07875	COG3729	General stress protein
I5M59_RS07885	COG2233	PERMEase
I5M59_RS07920	COG1309	transcriptional regulator
I5M59_RS07935	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I5M59_RS07945	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I5M59_RS07965	COG1702	phosphate starvation-inducible protein PhoH
I5M59_RS07985	COG1335	isochorismatase
I5M59_RS07995	COG0583	DNA-binding transcription factor activity
I5M59_RS08000	COG1309	transcriptional regulator
I5M59_RS08030	COG3381	protein complex oligomerization
I5M59_RS08065	COG5645	(Lipo)protein
I5M59_RS08080	COG1560	Kdo2-lipid A biosynthetic process
I5M59_RS08125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5M59_RS08145	COG2814	Major facilitator Superfamily
I5M59_RS08150	COG0583	DNA-binding transcription factor activity
I5M59_RS08155	COG1530	ribonuclease E activity
I5M59_RS08175	COG1399	metal-binding, possibly nucleic acid-binding protein
I5M59_RS08195	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I5M59_RS08210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I5M59_RS08215	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I5M59_RS08220	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I5M59_RS08230	COG0470	DNA polymerase III
I5M59_RS08235	COG0084	hydrolase, TatD family'
I5M59_RS08245	COG0537	adenosine 5'-monophosphoramidase activity
I5M59_RS08250	COG5633	Lipoprotein
I5M59_RS08275	COG1252	NADH dehydrogenase
I5M59_RS08280	COG3134	Outer membrane lipoprotein
I5M59_RS08295	COG1309	transcriptional regulator
I5M59_RS08310	COG1388	LysM domain
I5M59_RS08310	COG1376	ErfK ybiS ycfS ynhG family protein
I5M59_RS08315	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I5M59_RS08325	COG4591	ABC-type transport system involved in lipoprotein release permease component
I5M59_RS08335	COG4591	ABC-type transport system involved in lipoprotein release permease component
I5M59_RS08345	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I5M59_RS08355	COG2390	Transcriptional regulator
I5M59_RS08370	COG3395	kinase activity
I5M59_RS08385	COG0698	ribose 5-phosphate isomerase
I5M59_RS08390	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I5M59_RS08395	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I5M59_RS08400	COG0318	PFAM AMP-dependent synthetase and ligase
I5M59_RS08415	COG1177	transmembrane transport
I5M59_RS08435	COG2850	peptidyl-arginine hydroxylation
I5M59_RS08440	COG2205	protein histidine kinase activity
I5M59_RS08460	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I5M59_RS08480	COG1187	pseudouridine synthase activity
I5M59_RS08485	COG0538	isocitrate dehydrogenase activity
I5M59_RS08490	COG0640	Transcriptional regulator
I5M59_RS08510	COG3813	Protein conserved in bacteria
I5M59_RS08515	COG1063	alcohol dehydrogenase
I5M59_RS08525	COG3729	General stress protein
I5M59_RS08530	COG3685	Protein conserved in bacteria
I5M59_RS08535	COG3685	Protein conserved in bacteria
I5M59_RS08540	COG3546	catalase activity
I5M59_RS08545	COG1271	oxidase subunit
I5M59_RS08550	COG1294	oxidase, subunit
I5M59_RS08580	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I5M59_RS08585	COG0583	DNA-binding transcription factor activity
I5M59_RS08590	COG3706	GGDEF domain
I5M59_RS08595	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I5M59_RS08605	COG1560	Kdo2-lipid A biosynthetic process
I5M59_RS08615	COG3182	Iron-regulated membrane protein
I5M59_RS08635	COG2203	Gaf domain
I5M59_RS08635	COG2199	diguanylate cyclase activity
I5M59_RS08640	COG3042	response to heat
I5M59_RS08645	COG3189	MarR family transcriptional regulator
I5M59_RS08650	COG1683	Conserved Protein
I5M59_RS08655	COG0504	CTP synthase activity
I5M59_RS08660	COG2807	transmembrane transport
I5M59_RS08665	COG2207	Transcriptional regulator
I5M59_RS08675	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I5M59_RS08680	COG0859	PFAM glycosyl transferase family 9
I5M59_RS08690	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I5M59_RS08695	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I5M59_RS08700	COG0583	DNA-binding transcription factor activity
I5M59_RS08705	COG1028	Short-chain dehydrogenase reductase Sdr
I5M59_RS08730	COG0386	Belongs to the glutathione peroxidase family
I5M59_RS08745	COG2766	serine protein kinase
I5M59_RS08750	COG3713	MltA-interacting MipA family protein
I5M59_RS08755	COG0656	L-ascorbic acid biosynthetic process
I5M59_RS08775	COG3139	Protein of unknown function (DUF1315)
I5M59_RS08790	COG1063	alcohol dehydrogenase
I5M59_RS08795	COG2271	Major facilitator Superfamily
I5M59_RS08800	COG1063	alcohol dehydrogenase
I5M59_RS08805	COG0191	fructose-bisphosphate aldolase activity
I5M59_RS08810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5M59_RS08815	COG0667	Aldo Keto reductase
I5M59_RS08820	COG1349	DNA-binding transcription factor activity
I5M59_RS08825	COG2814	Major facilitator Superfamily
I5M59_RS08830	COG1335	isochorismatase
I5M59_RS08835	COG0252	asparaginase activity
I5M59_RS08840	COG0616	signal peptide processing
I5M59_RS08845	COG0778	Nitroreductase
I5M59_RS08855	COG0709	Synthesizes selenophosphate from selenide and ATP
I5M59_RS08860	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I5M59_RS08865	COG1028	Short-chain dehydrogenase reductase Sdr
I5M59_RS08865	COG0604	alcohol dehydrogenase
I5M59_RS08865	COG3321	synthase
I5M59_RS08870	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I5M59_RS08875	COG0494	nUDIX hydrolase
I5M59_RS08880	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I5M59_RS08885	COG2897	thiosulfate sulfurtransferase activity
I5M59_RS08890	COG4136	ATPase activity
I5M59_RS08895	COG4135	transport system, permease component
I5M59_RS08900	COG4134	Bacterial extracellular solute-binding protein
I5M59_RS08905	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5M59_RS08910	COG0398	Pfam SNARE associated Golgi protein
I5M59_RS08915	COG0398	Pfam SNARE associated Golgi protein
I5M59_RS08920	COG0708	Exodeoxyribonuclease III
I5M59_RS08930	COG3138	arginine N-succinyltransferase
I5M59_RS08940	COG3724	N-succinylarginine dihydrolase activity
I5M59_RS08950	COG3678	ATP-independent chaperone mediated protein folding
I5M59_RS08955	COG0322	excinuclease ABC activity
I5M59_RS08965	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I5M59_RS08970	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M59_RS08980	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M59_RS08985	COG1447	Phosphotransferase system cellobiose-specific component IIA
I5M59_RS08990	COG1917	Cupin 2, conserved barrel domain protein
I5M59_RS08990	COG2169	Transcriptional regulator
I5M59_RS08995	COG1486	melibiose metabolic process
I5M59_RS09005	COG0753	catalase activity
I5M59_RS09015	COG1823	symporter activity
I5M59_RS09020	COG1988	membrane-bound metal-dependent
I5M59_RS09025	COG1028	Short-chain dehydrogenase reductase Sdr
I5M59_RS09030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5M59_RS09060	COG0727	PFAM Uncharacterised protein family (UPF0153)
I5M59_RS09065	COG3047	cAMP biosynthetic process
I5M59_RS09075	COG4774	siderophore transport
I5M59_RS09110	COG0135	phosphoribosylanthranilate isomerase activity
I5M59_RS09110	COG0134	indole-3-glycerol-phosphate synthase activity
I5M59_RS09115	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I5M59_RS09115	COG0512	Glutamine amidotransferase of anthranilate synthase
I5M59_RS09120	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I5M59_RS09130	COG0009	L-threonylcarbamoyladenylate synthase
I5M59_RS09140	COG0583	DNA-binding transcription factor activity
I5M59_RS09150	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I5M59_RS09155	COG1028	Short-chain dehydrogenase reductase Sdr
I5M59_RS09165	COG0616	signal peptide processing
I5M59_RS09190	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I5M59_RS09200	COG0671	phosphoesterase, PA-phosphatase related
I5M59_RS09205	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I5M59_RS09210	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I5M59_RS09220	COG0023	Translation Initiation Factor
I5M59_RS09230	COG1349	DNA-binding transcription factor activity
I5M59_RS09245	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5M59_RS09245	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5M59_RS09250	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I5M59_RS09260	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I5M59_RS09275	COG4171	peptide transport system, permease
I5M59_RS09310	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I5M59_RS09340	COG1846	Transcriptional regulator
I5M59_RS09400	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I5M59_RS09405	COG0484	heat shock protein binding
I5M59_RS09440	COG5484	DNA packaging
I5M59_RS09440	COG3728	DNA packaging
I5M59_RS09530	COG1196	nuclear chromosome segregation
I5M59_RS09590	COG0438	transferase activity, transferring glycosyl groups
I5M59_RS09600	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I5M59_RS09620	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I5M59_RS09625	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I5M59_RS09630	COG2135	peptidase activity
I5M59_RS09645	COG0702	epimerase
I5M59_RS09660	COG1473	amidohydrolase
I5M59_RS09670	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I5M59_RS09675	COG1842	Phage shock protein A
I5M59_RS09685	COG1983	PspC domain protein
I5M59_RS09695	COG3106	COG3106 Predicted ATPase
I5M59_RS09705	COG0583	DNA-binding transcription factor activity
I5M59_RS09710	COG1486	melibiose metabolic process
I5M59_RS09720	COG3180	Ammonia monooxygenase
I5M59_RS09725	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I5M59_RS09730	COG4948	Mandelate Racemase Muconate Lactonizing
I5M59_RS09735	COG2866	Carboxypeptidase
I5M59_RS09745	COG4166	transmembrane transport
I5M59_RS09770	COG0656	L-ascorbic acid biosynthetic process
I5M59_RS09785	COG0583	DNA-binding transcription factor activity
I5M59_RS09790	COG1028	Short-chain dehydrogenase reductase Sdr
I5M59_RS09795	COG1078	dGTPase activity
I5M59_RS09800	COG0693	protein deglycase activity
I5M59_RS09825	COG2885	chlorophyll binding
I5M59_RS09900	COG1028	Short-chain dehydrogenase reductase Sdr
I5M59_RS09905	COG1309	transcriptional regulator
I5M59_RS09910	COG1028	Short-chain dehydrogenase reductase Sdr
I5M59_RS09930	COG0583	DNA-binding transcription factor activity
I5M59_RS09960	COG0604	alcohol dehydrogenase
I5M59_RS09965	COG0436	Aminotransferase
I5M59_RS09980	COG2011	ABC-type metal ion transport system permease component
I5M59_RS09995	COG0673	inositol 2-dehydrogenase activity
I5M59_RS10000	COG1349	DNA-binding transcription factor activity
I5M59_RS10010	COG0513	Belongs to the DEAD box helicase family
I5M59_RS10020	COG0589	response to stress
I5M59_RS10030	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I5M59_RS10035	COG1013	pyruvate-flavodoxin oxidoreductase activity
I5M59_RS10035	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I5M59_RS10035	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I5M59_RS10035	COG0674	pyruvate-flavodoxin oxidoreductase activity
I5M59_RS10040	COG3042	response to heat
I5M59_RS10045	COG3187	Heat shock protein
I5M59_RS10050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I5M59_RS10055	COG0586	Pfam SNARE associated Golgi protein
I5M59_RS10060	COG2911	Protein conserved in bacteria
I5M59_RS10070	COG3784	Protein of unknown function (DUF1318)
I5M59_RS10075	COG2207	Transcriptional regulator
I5M59_RS10080	COG1012	belongs to the aldehyde dehydrogenase family
I5M59_RS10095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M59_RS10105	COG1126	abc transporter atp-binding protein
I5M59_RS10110	COG0583	DNA-binding transcription factor activity
I5M59_RS10115	COG2072	flavoprotein involved in K transport
I5M59_RS10150	COG1012	belongs to the aldehyde dehydrogenase family
I5M59_RS10150	COG2030	dehydratase
I5M59_RS10155	COG3396	Phenylacetate-CoA oxygenase
I5M59_RS10160	COG3460	Phenylacetate-CoA oxygenase
I5M59_RS10165	COG3396	Phenylacetate-CoA oxygenase
I5M59_RS10170	COG2151	metal-sulfur cluster biosynthetic enzyme
I5M59_RS10175	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5M59_RS10180	COG1024	Enoyl-CoA hydratase
I5M59_RS10185	COG1024	Enoyl-CoA hydratase
I5M59_RS10190	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5M59_RS10195	COG2050	protein possibly involved in aromatic compounds catabolism
I5M59_RS10200	COG0183	Belongs to the thiolase family
I5M59_RS10205	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I5M59_RS10210	COG3327	negative regulation of DNA-templated transcription, initiation
I5M59_RS10215	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I5M59_RS10230	COG1643	Atp-dependent helicase
I5M59_RS10235	COG4122	O-methyltransferase activity
I5M59_RS10260	COG0583	DNA-binding transcription factor activity
I5M59_RS10265	COG0667	Aldo Keto reductase
I5M59_RS10270	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I5M59_RS10280	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I5M59_RS10285	COG3138	arginine N-succinyltransferase
I5M59_RS10290	COG1012	belongs to the aldehyde dehydrogenase family
I5M59_RS10295	COG3724	N-succinylarginine dihydrolase activity
I5M59_RS10300	COG2988	succinylglutamate desuccinylase activity
I5M59_RS10305	COG1113	amino acid transport
I5M59_RS10310	COG0477	Major facilitator Superfamily
I5M59_RS10315	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I5M59_RS10325	COG1012	belongs to the aldehyde dehydrogenase family
I5M59_RS10330	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I5M59_RS10335	COG0401	homolog of Blt101
I5M59_RS10340	COG5562	phage envelope protein
I5M59_RS10345	COG0425	Belongs to the sulfur carrier protein TusA family
I5M59_RS10350	COG2391	methyltransferase activity
I5M59_RS10375	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I5M59_RS10380	COG1263	PTS System
I5M59_RS10380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5M59_RS10385	COG1609	Transcriptional regulator
I5M59_RS10390	COG5339	Protein conserved in bacteria
I5M59_RS10395	COG1482	cell wall glycoprotein biosynthetic process
I5M59_RS10400	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I5M59_RS10400	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I5M59_RS10405	COG0114	fumarate hydratase activity
I5M59_RS10415	COG2205	protein histidine kinase activity
I5M59_RS10425	COG0745	RESPONSE REGULATOR receiver
I5M59_RS10430	COG3136	membrane protein required for alginate biosynthesis
I5M59_RS10440	COG0531	amino acid
I5M59_RS10455	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I5M59_RS10460	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I5M59_RS10475	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5M59_RS10490	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I5M59_RS10495	COG1473	amidohydrolase
I5M59_RS10505	COG0583	DNA-binding transcription factor activity
I5M59_RS10510	COG2840	Smr protein MutS2
I5M59_RS10515	COG1414	Transcriptional regulator
I5M59_RS10525	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I5M59_RS10530	COG0183	Belongs to the thiolase family
I5M59_RS10540	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I5M59_RS10545	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5M59_RS10555	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I5M59_RS10555	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I5M59_RS10575	COG4565	transcriptional regulatory protein
I5M59_RS10580	COG3290	protein histidine kinase activity
I5M59_RS10605	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I5M59_RS10615	COG0679	Auxin Efflux Carrier
I5M59_RS10645	COG0628	permease
I5M59_RS10665	COG3591	Belongs to the peptidase S1B family
I5M59_RS10675	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I5M59_RS10680	COG2814	Major facilitator Superfamily
I5M59_RS10685	COG0583	DNA-binding transcription factor activity
I5M59_RS10690	COG1940	carbohydrate kinase activity
I5M59_RS10695	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I5M59_RS10710	COG3302	dmso reductase anchor subunit
I5M59_RS10715	COG0437	4 iron, 4 sulfur cluster binding
I5M59_RS10720	COG0243	molybdopterin cofactor binding
I5M59_RS10735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5M59_RS10750	COG2271	Major facilitator Superfamily
I5M59_RS10755	COG0246	Mannitol dehydrogenase
I5M59_RS10760	COG0589	response to stress
I5M59_RS10765	COG1802	Transcriptional regulator
I5M59_RS10770	COG4221	oxidoreductase activity
I5M59_RS10785	COG2207	Transcriptional regulator
I5M59_RS10790	COG2135	peptidase activity
I5M59_RS10820	COG0071	Belongs to the small heat shock protein (HSP20) family
I5M59_RS10825	COG1546	Belongs to the CinA family
I5M59_RS10830	COG2200	EAL domain
I5M59_RS10845	COG2207	Transcriptional regulator
I5M59_RS10845	COG3708	Transcriptional regulator
I5M59_RS10850	COG2610	gluconate transmembrane transporter activity
I5M59_RS10855	COG3622	Belongs to the hyi family
I5M59_RS10860	COG0235	Class ii aldolase
I5M59_RS10875	COG1349	DNA-binding transcription factor activity
I5M59_RS10890	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I5M59_RS10895	COG2223	nitrite transmembrane transporter activity
I5M59_RS10930	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I5M59_RS10950	COG1129	ABC transporter
I5M59_RS10965	COG2814	Major facilitator Superfamily
I5M59_RS10970	COG0697	spore germination
I5M59_RS10980	COG4977	sequence-specific DNA binding
I5M59_RS11010	COG1028	Short-chain dehydrogenase reductase Sdr
I5M59_RS11015	COG2731	YhcH YjgK YiaL family protein
I5M59_RS11030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I5M59_RS11040	COG3395	kinase activity
I5M59_RS11045	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I5M59_RS11050	COG1349	DNA-binding transcription factor activity
I5M59_RS11055	COG0039	L-malate dehydrogenase activity
I5M59_RS11065	COG0583	DNA-binding transcription factor activity
I5M59_RS11070	COG1012	belongs to the aldehyde dehydrogenase family
I5M59_RS11085	COG2199	diguanylate cyclase activity
I5M59_RS11135	COG0477	Major facilitator Superfamily
I5M59_RS11145	COG2070	2-Nitropropane dioxygenase
I5M59_RS11150	COG2011	ABC-type metal ion transport system permease component
I5M59_RS11170	COG4628	conserved protein (DUF2132)
I5M59_RS11185	COG2207	Transcriptional regulator
I5M59_RS11215	COG2233	PERMEase
I5M59_RS11220	COG3648	Uricase
I5M59_RS11220	COG3195	allantoin biosynthetic process
I5M59_RS11225	COG2351	hydroxyisourate hydrolase activity
I5M59_RS11230	COG1396	sequence-specific DNA binding
I5M59_RS11235	COG3550	peptidyl-serine autophosphorylation
I5M59_RS11240	COG1649	PFAM Uncharacterised BCR, COG1649
I5M59_RS11250	COG3188	usher protein
I5M59_RS11285	COG5001	Diguanylate cyclase
I5M59_RS11285	COG3300	MHYT domain
I5M59_RS11290	COG2819	hydrolase of the alpha beta superfamily
I5M59_RS11305	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M59_RS11305	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M59_RS11310	COG2814	Major facilitator Superfamily
I5M59_RS11320	COG1263	PTS System
I5M59_RS11320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5M59_RS11325	COG2186	Transcriptional regulator
I5M59_RS11335	COG0583	DNA-binding transcription factor activity
I5M59_RS11345	COG3835	regulator
I5M59_RS11350	COG1929	Belongs to the glycerate kinase type-1 family
I5M59_RS11395	COG0738	Major facilitator superfamily
I5M59_RS11400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5M59_RS11405	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I5M59_RS11410	COG1349	DNA-binding transcription factor activity
I5M59_RS11425	COG1349	DNA-binding transcription factor activity
I5M59_RS11430	COG4977	sequence-specific DNA binding
I5M59_RS11450	COG4977	sequence-specific DNA binding
I5M59_RS11465	COG2801	Transposase and inactivated derivatives
I5M59_RS11495	COG0667	Aldo Keto reductase
I5M59_RS11505	COG0456	acetyltransferase
I5M59_RS11505	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I5M59_RS11530	COG1652	LysM domain
I5M59_RS11560	COG1609	Transcriptional regulator
I5M59_RS11570	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M59_RS11585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I5M59_RS11595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5M59_RS11600	COG0583	DNA-binding transcription factor activity
I5M59_RS11605	COG0583	DNA-binding transcription factor activity
I5M59_RS11620	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I5M59_RS11620	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5M59_RS11620	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5M59_RS11625	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5M59_RS11635	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I5M59_RS11660	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M59_RS11665	COG1609	Transcriptional regulator
I5M59_RS11675	COG2223	nitrite transmembrane transporter activity
I5M59_RS11705	COG0477	Major facilitator Superfamily
I5M59_RS11710	COG4529	Protein conserved in bacteria
I5M59_RS11715	COG1902	pentaerythritol trinitrate reductase activity
I5M59_RS11725	COG0583	DNA-binding transcription factor activity
I5M59_RS11730	COG2070	2-Nitropropane dioxygenase
I5M59_RS11740	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I5M59_RS11750	COG0765	amino acid transport
I5M59_RS11815	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I5M59_RS11830	COG2207	Transcriptional regulator
I5M59_RS11845	COG1335	isochorismatase
I5M59_RS11850	COG0406	alpha-ribazole phosphatase activity
I5M59_RS11885	COG1953	Uracil, thiamine, allantoin
I5M59_RS11890	COG0402	S-adenosylhomocysteine deaminase activity
I5M59_RS11895	COG3706	GGDEF domain
I5M59_RS11900	COG1609	Transcriptional regulator
I5M59_RS11910	COG0673	inositol 2-dehydrogenase activity
I5M59_RS11925	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I5M59_RS11930	COG1116	anion transmembrane transporter activity
I5M59_RS11935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5M59_RS11940	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5M59_RS11945	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I5M59_RS11950	COG0076	glutamate decarboxylase activity
I5M59_RS11965	COG2205	protein histidine kinase activity
I5M59_RS11975	COG0596	Alpha beta hydrolase
I5M59_RS12015	COG0519	Catalyzes the synthesis of GMP from XMP
I5M59_RS12015	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I5M59_RS12035	COG0583	DNA-binding transcription factor activity
I5M59_RS12045	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I5M59_RS12050	COG1285	pathogenesis
I5M59_RS12055	COG2814	Major facilitator Superfamily
I5M59_RS12060	COG0583	DNA-binding transcription factor activity
I5M59_RS12065	COG0243	molybdopterin cofactor binding
I5M59_RS12070	COG3781	membrane
I5M59_RS12095	COG1764	response to oxidative stress
I5M59_RS12105	COG3111	PFAM Bacterial OB fold (BOF) protein
I5M59_RS12115	COG2323	membrane
I5M59_RS12125	COG0366	Alpha amylase catalytic
I5M59_RS12135	COG3685	Protein conserved in bacteria
I5M59_RS12145	COG3729	General stress protein
I5M59_RS12150	COG1028	Short-chain dehydrogenase reductase Sdr
I5M59_RS12190	COG0488	(ABC) transporter
I5M59_RS12205	COG1064	alcohol dehydrogenase
I5M59_RS12210	COG0747	negative chemotaxis
I5M59_RS12220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5M59_RS12230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5M59_RS12240	COG2814	Major facilitator Superfamily
I5M59_RS12250	COG2326	polyphosphate kinase activity
I5M59_RS12265	COG2864	formate dehydrogenase
I5M59_RS12270	COG0437	4 iron, 4 sulfur cluster binding
I5M59_RS12305	COG3485	protocatechuate 3,4-dioxygenase
I5M59_RS12310	COG4829	muconolactone delta-isomerase
I5M59_RS12315	COG4948	Mandelate Racemase Muconate Lactonizing
I5M59_RS12320	COG1414	Transcriptional regulator
I5M59_RS12340	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I5M59_RS12345	COG1140	nitrate reductase beta subunit
I5M59_RS12350	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I5M59_RS12355	COG2181	nitrate reductase activity
I5M59_RS12360	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I5M59_RS12365	COG1178	ABC-type Fe3 transport system permease component
I5M59_RS12370	COG1840	ABC-type Fe3 transport system, periplasmic component
I5M59_RS12375	COG3842	ATPase activity
I5M59_RS12380	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I5M59_RS12395	COG2211	Major facilitator Superfamily
I5M59_RS12425	COG0625	glutathione transferase activity
I5M59_RS12435	COG1126	abc transporter atp-binding protein
I5M59_RS12440	COG0765	amino acid transport
I5M59_RS12450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M59_RS12455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5M59_RS12460	COG1473	amidohydrolase
I5M59_RS12465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5M59_RS12470	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I5M59_RS12495	COG4772	TonB-dependent receptor
I5M59_RS12500	COG1228	amidohydrolase
I5M59_RS12505	COG3691	Protein conserved in bacteria
I5M59_RS12520	COG2130	NADP-dependent
I5M59_RS12530	COG1247	-acetyltransferase
I5M59_RS12535	COG3238	Protein conserved in bacteria
I5M59_RS12545	COG0747	negative chemotaxis
I5M59_RS12550	COG1012	belongs to the aldehyde dehydrogenase family
I5M59_RS12585	COG1012	belongs to the aldehyde dehydrogenase family
I5M59_RS12590	COG1177	transmembrane transport
I5M59_RS12595	COG1176	ABC-type spermidine putrescine transport system, permease component I
I5M59_RS12600	COG3842	ATPase activity
I5M59_RS12605	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I5M59_RS12610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5M59_RS12615	COG1271	oxidase subunit
I5M59_RS12620	COG1294	oxidase, subunit
I5M59_RS12640	COG0826	peptidase U32
I5M59_RS12650	COG1396	sequence-specific DNA binding
I5M59_RS12655	COG3135	benzoate transporter
I5M59_RS12660	COG3708	Transcriptional regulator
I5M59_RS12660	COG2207	Transcriptional regulator
I5M59_RS12675	COG0500	methyltransferase
I5M59_RS12680	COG1275	C4-dicarboxylate transporter malic acid transport protein
I5M59_RS12685	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I5M59_RS12690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5M59_RS12705	COG2272	Belongs to the type-B carboxylesterase lipase family
I5M59_RS12710	COG5383	Protein conserved in bacteria
I5M59_RS12715	COG3485	protocatechuate 3,4-dioxygenase
I5M59_RS12720	COG3485	protocatechuate 3,4-dioxygenase
I5M59_RS12725	COG0583	DNA-binding transcription factor activity
I5M59_RS12745	COG3038	cytochrome b561
I5M59_RS12775	COG0673	inositol 2-dehydrogenase activity
I5M59_RS12785	COG2723	6-phospho-beta-galactosidase activity
I5M59_RS12820	COG4659	FMN binding
I5M59_RS12830	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I5M59_RS12840	COG0625	glutathione transferase activity
I5M59_RS12845	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I5M59_RS12860	COG3895	Periplasmic Protein
I5M59_RS12875	COG3706	GGDEF domain
I5M59_RS12890	COG1566	PFAM secretion protein HlyD family protein
I5M59_RS12895	COG1289	transmembrane transporter activity
I5M59_RS12900	COG2032	superoxide dismutase activity
I5M59_RS12905	COG4989	oxidoreductase activity
I5M59_RS12910	COG3313	Fe-S protein
I5M59_RS12915	COG1309	transcriptional regulator
I5M59_RS12920	COG1902	pentaerythritol trinitrate reductase activity
I5M59_RS12925	COG0346	lactoylglutathione lyase activity
I5M59_RS12935	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I5M59_RS12940	COG0791	NLP P60 protein
I5M59_RS12955	COG2814	Major facilitator Superfamily
I5M59_RS12970	COG0583	DNA-binding transcription factor activity
I5M59_RS12975	COG2814	Major facilitator Superfamily
I5M59_RS12980	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I5M59_RS12985	COG0307	riboflavin synthase, alpha
I5M59_RS13040	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I5M59_RS13075	COG1349	DNA-binding transcription factor activity
I5M59_RS13080	COG0346	lactoylglutathione lyase activity
I5M59_RS13105	COG0444	Belongs to the ABC transporter superfamily
I5M59_RS13110	COG4608	Belongs to the ABC transporter superfamily
I5M59_RS13140	COG3321	synthase
I5M59_RS13140	COG0604	alcohol dehydrogenase
I5M59_RS13140	COG1028	Short-chain dehydrogenase reductase Sdr
I5M59_RS13180	COG0402	S-adenosylhomocysteine deaminase activity
I5M59_RS13205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5M59_RS13210	COG0277	FAD linked oxidase domain protein
I5M59_RS13235	COG0583	DNA-binding transcription factor activity
I5M59_RS13245	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I5M59_RS13255	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5M59_RS13260	COG2610	gluconate transmembrane transporter activity
I5M59_RS13265	COG1028	Short-chain dehydrogenase reductase Sdr
I5M59_RS13295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5M59_RS13310	COG0745	RESPONSE REGULATOR receiver
I5M59_RS13315	COG3850	Histidine kinase
I5M59_RS13315	COG5002	protein histidine kinase activity
I5M59_RS13330	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I5M59_RS13350	COG3088	subunit of a heme lyase
I5M59_RS13350	COG4235	cytochrome complex assembly
I5M59_RS13355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5M59_RS13360	COG1138	Cytochrome C-type biogenesis protein
I5M59_RS13375	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I5M59_RS13380	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I5M59_RS13385	COG4133	protoheme IX ABC transporter activity
I5M59_RS13415	COG1175	transmembrane transport
I5M59_RS13425	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I5M59_RS13430	COG3383	formate dehydrogenase (NAD+) activity
I5M59_RS13470	COG1126	abc transporter atp-binding protein
I5M59_RS13475	COG0765	amino acid transport
I5M59_RS13495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M59_RS13500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M59_RS13505	COG1120	ATPase activity
I5M59_RS13510	COG4774	siderophore transport
I5M59_RS13515	COG1116	anion transmembrane transporter activity
I5M59_RS13520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5M59_RS13540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5M59_RS13545	COG0583	DNA-binding transcription factor activity
I5M59_RS13565	COG2814	Major facilitator Superfamily
I5M59_RS13600	COG1414	Transcriptional regulator
I5M59_RS13605	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I5M59_RS13610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M59_RS13615	COG1120	ATPase activity
I5M59_RS13625	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I5M59_RS13630	COG2271	Major facilitator Superfamily
I5M59_RS13635	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I5M59_RS13635	COG1082	Xylose isomerase domain protein TIM barrel
I5M59_RS13640	COG1309	transcriptional regulator
I5M59_RS13670	COG1376	ErfK ybiS ycfS ynhG family protein
I5M59_RS13685	COG0719	Fe-S assembly protein
I5M59_RS13690	COG0396	ATPase activity
I5M59_RS13695	COG0719	Fe-S assembly protein
I5M59_RS13700	COG0316	Belongs to the HesB IscA family
I5M59_RS13715	COG1304	FMN binding
I5M59_RS13740	COG0583	DNA-binding transcription factor activity
I5M59_RS13750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M59_RS13755	COG1120	ATPase activity
I5M59_RS13780	COG2261	transglycosylase associated protein
I5M59_RS13785	COG2050	protein possibly involved in aromatic compounds catabolism
I5M59_RS13790	COG0247	lactate metabolic process
I5M59_RS13790	COG0277	FAD linked oxidase domain protein
I5M59_RS13795	COG0628	permease
I5M59_RS13805	COG0574	Belongs to the PEP-utilizing enzyme family
I5M59_RS13805	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I5M59_RS13820	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I5M59_RS13825	COG4256	Hemin uptake protein
I5M59_RS13835	COG0791	NLP P60 protein
I5M59_RS13845	COG0386	Belongs to the glutathione peroxidase family
I5M59_RS13865	COG0583	DNA-binding transcription factor activity
I5M59_RS13885	COG0072	phenylalanine-tRNA ligase activity
I5M59_RS13885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I5M59_RS13925	COG3137	Salt-induced outer membrane protein
I5M59_RS13930	COG1105	Belongs to the carbohydrate kinase PfkB family
I5M59_RS13940	COG3001	Fructosamine kinase
I5M59_RS13950	COG2350	Protein conserved in bacteria
I5M59_RS13960	COG2353	YceI-like domain
I5M59_RS13980	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5M59_RS13990	COG0444	Belongs to the ABC transporter superfamily
I5M59_RS13995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5M59_RS14000	COG0601	transmembrane transport
I5M59_RS14005	COG4166	transmembrane transport
I5M59_RS14010	COG2095	MarC family integral membrane protein
I5M59_RS14020	COG1012	belongs to the aldehyde dehydrogenase family
I5M59_RS14020	COG1454	alcohol dehydrogenase
I5M59_RS14025	COG1435	thymidine kinase activity
I5M59_RS14035	COG2916	Histone family protein nucleoid-structuring protein H-NS
I5M59_RS14040	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I5M59_RS14045	COG0745	RESPONSE REGULATOR receiver
I5M59_RS14050	COG1752	Esterase of the alpha-beta hydrolase superfamily
I5M59_RS14060	COG0788	formyltetrahydrofolate deformylase activity
I5M59_RS14090	COG1522	sequence-specific DNA binding
I5M59_RS14100	COG2181	nitrate reductase activity
I5M59_RS14105	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I5M59_RS14110	COG1140	nitrate reductase beta subunit
I5M59_RS14115	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I5M59_RS14125	COG2223	nitrite transmembrane transporter activity
I5M59_RS14130	COG3850	Histidine kinase
I5M59_RS14135	COG2197	response regulator
I5M59_RS14140	COG4932	domain protein
I5M59_RS14145	COG0243	molybdopterin cofactor binding
I5M59_RS14150	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I5M59_RS14150	COG2146	nitrite reductase [NAD(P)H] activity
I5M59_RS14155	COG1116	anion transmembrane transporter activity
I5M59_RS14165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5M59_RS14170	COG3707	response regulator
I5M59_RS14175	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I5M59_RS14185	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I5M59_RS14190	COG4572	Cation transport regulator
I5M59_RS14195	COG0387	Pfam Sodium calcium exchanger
I5M59_RS14215	COG2890	protein-(glutamine-N5) methyltransferase activity
I5M59_RS14245	COG0659	secondary active sulfate transmembrane transporter activity
I5M59_RS14265	COG0012	GTP binding
I5M59_RS14370	COG2885	chlorophyll binding
I5M59_RS14390	COG3122	Protein conserved in bacteria
I5M59_RS14405	COG0583	DNA-binding transcription factor activity
I5M59_RS14435	COG0583	DNA-binding transcription factor activity
I5M59_RS14470	COG1882	Formate acetyltransferase
I5M59_RS14485	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I5M59_RS14490	COG0583	DNA-binding transcription factor activity
I5M59_RS14535	COG2308	Evidence 4 Homologs of previously reported genes of
I5M59_RS14550	COG4774	siderophore transport
I5M59_RS14560	COG1619	proteins homologs of microcin C7 resistance protein MccF
I5M59_RS14585	COG2719	SpoVR family
I5M59_RS14615	COG0179	Fumarylacetoacetate (FAA) hydrolase
I5M59_RS14630	COG2894	cell division
I5M59_RS14640	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I5M59_RS14650	COG3065	identical protein binding
I5M59_RS14660	COG1199	ATP-dependent helicase activity
I5M59_RS14665	COG0251	oxidation-reduction process
I5M59_RS14685	COG1760	l-serine dehydratase
I5M59_RS14690	COG2200	EAL domain
I5M59_RS14695	COG1253	flavin adenine dinucleotide binding
I5M59_RS14700	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5M59_RS14700	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M59_RS14705	COG3715	PTS system
I5M59_RS14710	COG3716	PTS system mannose fructose sorbose family IID component
I5M59_RS14725	COG2226	methyltransferase
I5M59_RS14730	COG0768	penicillin binding
I5M59_RS14760	COG1414	Transcriptional regulator
I5M59_RS14765	COG2814	Major facilitator Superfamily
I5M59_RS14785	COG1956	GAF domain-containing protein
I5M59_RS14790	COG2995	paraquat-inducible protein a
I5M59_RS14795	COG3008	intermembrane lipid transfer
I5M59_RS14820	COG2990	Protein conserved in bacteria
I5M59_RS14835	COG1276	copper resistance
I5M59_RS14840	COG2372	response to copper ion
I5M59_RS14850	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I5M59_RS14855	COG1770	oligopeptidase
I5M59_RS14860	COG2979	Protein of unknown function (DUF533)
I5M59_RS14865	COG3141	response to X-ray
I5M59_RS14875	COG0800	Aldolase
I5M59_RS14880	COG0129	dihydroxy-acid dehydratase activity
I5M59_RS14885	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I5M59_RS14895	COG1737	Transcriptional regulator
I5M59_RS14905	COG1560	Kdo2-lipid A biosynthetic process
I5M59_RS14910	COG0739	heme binding
I5M59_RS14915	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I5M59_RS14925	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5M59_RS14950	COG0494	nUDIX hydrolase
I5M59_RS14960	COG1335	isochorismatase
I5M59_RS14965	COG1801	Protein of unknown function DUF72
I5M59_RS14990	COG3102	Protein conserved in bacteria
I5M59_RS15000	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I5M59_RS15025	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M59_RS15035	COG1879	ABC-type sugar transport system periplasmic component
I5M59_RS15045	COG1528	Iron-storage protein
I5M59_RS15055	COG2211	Major facilitator Superfamily
I5M59_RS15065	COG0477	Major facilitator Superfamily
I5M59_RS15080	COG1528	Iron-storage protein
I5M59_RS15090	COG0814	amino acid
I5M59_RS15095	COG3318	Belongs to the UPF0149 family
I5M59_RS15095	COG3012	SEC-C Motif Domain Protein
I5M59_RS15130	COG2197	response regulator
I5M59_RS15140	COG2197	response regulator
I5M59_RS15145	COG1126	abc transporter atp-binding protein
I5M59_RS15150	COG0765	amino acid transport
I5M59_RS15160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M59_RS15165	COG0366	Alpha amylase catalytic
I5M59_RS15195	COG2354	Protein conserved in bacteria
I5M59_RS15200	COG0697	spore germination
I5M59_RS15205	COG3727	T/G mismatch-specific endonuclease activity
I5M59_RS15210	COG0270	DNA (cytosine-5-)-methyltransferase activity
I5M59_RS15215	COG1418	mRNA catabolic process
I5M59_RS15225	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I5M59_RS15270	COG0025	NhaP-type Na H and K H
I5M59_RS15275	COG1309	transcriptional regulator
I5M59_RS15280	COG0604	alcohol dehydrogenase
I5M59_RS15300	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I5M59_RS15310	COG0534	Mate efflux family protein
I5M59_RS15330	COG3706	GGDEF domain
I5M59_RS15355	COG3615	Tellurite resistance protein tehB
I5M59_RS15360	COG3300	MHYT domain
I5M59_RS15360	COG5001	Diguanylate cyclase
I5M59_RS15370	COG0477	Major facilitator Superfamily
I5M59_RS15375	COG0095	Lipoate-protein ligase
I5M59_RS15380	COG0583	DNA-binding transcription factor activity
I5M59_RS15385	COG1942	4-Oxalocrotonate Tautomerase
I5M59_RS15395	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I5M59_RS15415	COG1289	transmembrane transporter activity
I5M59_RS15430	COG2925	Exonuclease
I5M59_RS15435	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I5M59_RS15440	COG0640	Transcriptional regulator
I5M59_RS15445	COG0531	amino acid
I5M59_RS15455	COG0583	DNA-binding transcription factor activity
I5M59_RS15460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I5M59_RS15490	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I5M59_RS15515	COG0438	transferase activity, transferring glycosyl groups
I5M59_RS15605	COG0438	transferase activity, transferring glycosyl groups
I5M59_RS15625	COG0438	transferase activity, transferring glycosyl groups
I5M59_RS15630	COG0438	transferase activity, transferring glycosyl groups
I5M59_RS15680	COG1253	flavin adenine dinucleotide binding
I5M59_RS15685	COG2982	Protein involved in outer membrane biogenesis
I5M59_RS15700	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I5M59_RS15705	COG0443	Heat shock 70 kDa protein
I5M59_RS15730	COG1301	dicarboxylic acid transport
I5M59_RS15755	COG2205	protein histidine kinase activity
I5M59_RS15760	COG0745	RESPONSE REGULATOR receiver
I5M59_RS15765	COG0826	peptidase U32
I5M59_RS15775	COG4608	Belongs to the ABC transporter superfamily
I5M59_RS15780	COG0444	Belongs to the ABC transporter superfamily
I5M59_RS15785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5M59_RS15790	COG0601	transmembrane transport
I5M59_RS15795	COG0747	negative chemotaxis
I5M59_RS15800	COG4948	Mandelate Racemase Muconate Lactonizing
I5M59_RS15805	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5M59_RS15815	COG1070	Carbohydrate kinase
I5M59_RS15840	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I5M59_RS15850	COG1830	Aldolase
I5M59_RS15855	COG0351	phosphomethylpyrimidine kinase
I5M59_RS15870	COG0583	DNA-binding transcription factor activity
I5M59_RS15880	COG2252	PERMEase
I5M59_RS15885	COG0583	DNA-binding transcription factor activity
I5M59_RS15890	COG5455	response to cobalt ion
I5M59_RS15910	COG4807	Protein conserved in bacteria
I5M59_RS15920	COG3275	phosphorelay sensor kinase activity
I5M59_RS15930	COG1174	glycine betaine transport
I5M59_RS15935	COG1125	glycine betaine transport
I5M59_RS15940	COG1174	glycine betaine transport
I5M59_RS15945	COG1732	Glycine betaine
I5M59_RS15950	COG1472	Belongs to the glycosyl hydrolase 3 family
I5M59_RS15955	COG0277	FAD linked oxidase domain protein
I5M59_RS15965	COG1686	Belongs to the peptidase S11 family
I5M59_RS15975	COG0586	Pfam SNARE associated Golgi protein
I5M59_RS15980	COG1538	Outer membrane efflux protein
I5M59_RS15985	COG2723	6-phospho-beta-galactosidase activity
I5M59_RS16000	COG3659	wide pore channel activity
I5M59_RS16005	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I5M59_RS16015	COG1346	cytolysis
I5M59_RS16025	COG2949	membrane
I5M59_RS16035	COG1129	ABC transporter
I5M59_RS16050	COG2311	Membrane
I5M59_RS16065	COG4771	TonB-dependent receptor
I5M59_RS16070	COG0833	amino acid
I5M59_RS16075	COG0583	DNA-binding transcription factor activity
I5M59_RS16080	COG2855	membrane
I5M59_RS16090	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5M59_RS16090	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I5M59_RS16090	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5M59_RS16095	COG1105	Belongs to the carbohydrate kinase PfkB family
I5M59_RS16100	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M59_RS16100	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M59_RS16120	COG1312	Catalyzes the dehydration of D-mannonate
I5M59_RS16125	COG0246	Mannitol dehydrogenase
I5M59_RS16130	COG0523	cobalamin synthesis protein
I5M59_RS16135	COG0671	phosphoesterase, PA-phosphatase related
I5M59_RS16140	COG0791	NLP P60 protein
I5M59_RS16145	COG2200	EAL domain
I5M59_RS16150	COG4166	transmembrane transport
I5M59_RS16155	COG4174	ABC transporter (Permease)
I5M59_RS16160	COG4239	(ABC) transporter, permease
I5M59_RS16165	COG4172	Belongs to the ABC transporter superfamily
I5M59_RS16175	COG2814	Major facilitator Superfamily
I5M59_RS16180	COG1187	pseudouridine synthase activity
I5M59_RS16185	COG1061	Type III restriction enzyme res subunit
I5M59_RS16205	COG0494	nUDIX hydrolase
I5M59_RS16210	COG1349	DNA-binding transcription factor activity
I5M59_RS16235	COG0628	permease
I5M59_RS16250	COG0659	secondary active sulfate transmembrane transporter activity
I5M59_RS16255	COG2239	Acts as a magnesium transporter
I5M59_RS16260	COG4615	Cyclic peptide transporter
I5M59_RS16265	COG3145	DNA-N1-methyladenine dioxygenase activity
I5M59_RS16270	COG2169	Transcriptional regulator
I5M59_RS16270	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I5M59_RS16285	COG2198	Histidine kinase
I5M59_RS16285	COG0642	Histidine kinase
I5M59_RS16295	COG2205	protein histidine kinase activity
I5M59_RS16295	COG0784	Response regulator, receiver
I5M59_RS16320	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5M59_RS16330	COG2271	Major facilitator Superfamily
I5M59_RS16335	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I5M59_RS16345	COG0247	lactate metabolic process
I5M59_RS16355	COG2271	Major facilitator Superfamily
I5M59_RS16365	COG1414	Transcriptional regulator
I5M59_RS16380	COG5464	transposase or invertase
I5M59_RS16390	COG0318	PFAM AMP-dependent synthetase and ligase
I5M59_RS16415	COG1169	isochorismate synthase
I5M59_RS16420	COG2153	protein acetylation
I5M59_RS16435	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I5M59_RS16440	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I5M59_RS16450	COG0839	Belongs to the complex I subunit 6 family
I5M59_RS16495	COG0583	DNA-binding transcription factor activity
I5M59_RS16500	COG0436	Aminotransferase
I5M59_RS16510	COG0490	domain, Protein
I5M59_RS16510	COG0471	metal ion transport
I5M59_RS16515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5M59_RS16535	COG0280	phosphate acetyltransferase
I5M59_RS16535	COG0857	belongs to the CobB CobQ family
I5M59_RS16540	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I5M59_RS16545	COG0622	Phosphoesterase
I5M59_RS16550	COG0625	glutathione transferase activity
I5M59_RS16555	COG0625	glutathione transferase activity
I5M59_RS16560	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I5M59_RS16565	COG1090	epimerase
I5M59_RS16580	COG4598	ABC transporter
I5M59_RS16585	COG4160	amino acid transport
I5M59_RS16610	COG0163	prenyltransferase activity
I5M59_RS16615	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I5M59_RS16620	COG1286	toxin biosynthetic process
I5M59_RS16625	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I5M59_RS16630	COG0285	dihydrofolate synthase activity
I5M59_RS16640	COG0586	Pfam SNARE associated Golgi protein
I5M59_RS16650	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I5M59_RS16670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I5M59_RS16685	COG3101	peptidyl-lysine hydroxylation
I5M59_RS16690	COG0730	response to heat
I5M59_RS16715	COG2062	phosphohistidine phosphatase, SixA
I5M59_RS16730	COG3691	Protein conserved in bacteria
I5M59_RS16740	COG2853	Lipoprotein
I5M59_RS16745	COG2116	formate transmembrane transporter activity
I5M59_RS16765	COG0583	DNA-binding transcription factor activity
I5M59_RS16770	COG0590	tRNA wobble adenosine to inosine editing
I5M59_RS16775	COG2807	transmembrane transport
I5M59_RS16785	COG0436	Aminotransferase
I5M59_RS16800	COG3275	phosphorelay sensor kinase activity
I5M59_RS16805	COG3279	Response regulator of the LytR AlgR family
I5M59_RS16820	COG3961	Belongs to the TPP enzyme family
I5M59_RS16825	COG0667	Aldo Keto reductase
I5M59_RS16840	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I5M59_RS16845	COG2200	EAL domain
I5M59_RS16845	COG2199	diguanylate cyclase activity
I5M59_RS16860	COG3415	Transposase
I5M59_RS16865	COG3415	Transposase
I5M59_RS16895	COG0583	DNA-binding transcription factor activity
I5M59_RS16900	COG0385	Bile acid
I5M59_RS16905	COG3530	Putative quorum-sensing-regulated virulence factor
I5M59_RS16925	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I5M59_RS16960	COG4319	ketosteroid isomerase
I5M59_RS16970	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I5M59_RS16975	COG4208	sulfate ABC transporter
I5M59_RS16980	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I5M59_RS16985	COG4150	thiosulfate binding
I5M59_RS16995	COG2837	iron assimilation
I5M59_RS17015	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5M59_RS17105	COG4810	utilization protein
I5M59_RS17115	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I5M59_RS17120	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I5M59_RS17125	COG5342	invasion associated locus B
I5M59_RS17135	COG0493	'glutamate synthase
I5M59_RS17135	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I5M59_RS17140	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5M59_RS17150	COG1393	Belongs to the ArsC family
I5M59_RS17165	COG0400	carboxylic ester hydrolase activity
I5M59_RS17170	COG1444	tRNA N-acetyltransferase activity
I5M59_RS17175	COG2321	neutral zinc metallopeptidase
I5M59_RS17185	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I5M59_RS17195	COG2716	regulation of RNA biosynthetic process
I5M59_RS17200	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I5M59_RS17205	COG0628	permease
I5M59_RS17215	COG4783	chaperone-mediated protein folding
I5M59_RS17220	COG1393	Belongs to the ArsC family
I5M59_RS17235	COG2233	PERMEase
I5M59_RS17245	COG2723	6-phospho-beta-galactosidase activity
I5M59_RS17260	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I5M59_RS17275	COG2200	EAL domain
I5M59_RS17295	COG0641	radical SAM
I5M59_RS17300	COG3119	arylsulfatase activity
I5M59_RS17355	COG3093	addiction module antidote protein HigA
I5M59_RS17405	COG0582	viral genome integration into host DNA
I5M59_RS17415	COG0516	GMP reductase activity
I5M59_RS17415	COG0517	IMP dehydrogenase activity
I5M59_RS17425	COG1645	bacterial-type flagellum-dependent swarming motility
I5M59_RS17445	COG2976	Protein conserved in bacteria
I5M59_RS17475	COG4953	penicillin-binding protein 1C
I5M59_RS17480	COG2373	Large extracellular alpha-helical protein
I5M59_RS17485	COG2897	thiosulfate sulfurtransferase activity
I5M59_RS17505	COG2975	iron-sulfur cluster assembly
I5M59_RS17510	COG0633	Ferredoxin
I5M59_RS17530	COG0822	iron-sulfur transferase activity
I5M59_RS17560	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I5M59_RS17565	COG3683	transport system, periplasmic component
I5M59_RS17570	COG3711	transcriptional antiterminator
I5M59_RS17575	COG2814	Major facilitator Superfamily
I5M59_RS17580	COG2017	converts alpha-aldose to the beta-anomer
I5M59_RS17585	COG0477	Major facilitator Superfamily
I5M59_RS17585	COG2814	Major facilitator Superfamily
I5M59_RS17590	COG0457	Tetratricopeptide repeat
I5M59_RS17595	COG1940	carbohydrate kinase activity
I5M59_RS17600	COG2259	Doxx family
I5M59_RS17610	COG1017	nitric oxide dioxygenase activity
I5M59_RS17610	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5M59_RS17615	COG0347	Belongs to the P(II) protein family
I5M59_RS17620	COG2204	response regulator
I5M59_RS17625	COG3170	Tfp pilus assembly protein FimV
I5M59_RS17630	COG2205	protein histidine kinase activity
I5M59_RS17635	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I5M59_RS17635	COG0047	phosphoribosylformylglycinamidine synthase activity
I5M59_RS17650	COG0560	Phosphoserine phosphatase
I5M59_RS17655	COG1737	Transcriptional regulator
I5M59_RS17660	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I5M59_RS17670	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I5M59_RS17690	COG0681	Belongs to the peptidase S26 family
I5M59_RS17700	COG3086	response to oxidative stress
I5M59_RS17705	COG3026	antisigma factor binding
I5M59_RS17710	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I5M59_RS17725	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I5M59_RS17735	COG0513	Belongs to the DEAD box helicase family
I5M59_RS17750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I5M59_RS17755	COG3118	belongs to the thioredoxin family
I5M59_RS17760	COG3148	PFAM DTW domain containing protein
I5M59_RS17770	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5M59_RS17775	COG5544	Lipoprotein
I5M59_RS17780	COG0477	Major facilitator Superfamily
I5M59_RS17805	COG0542	response to heat
I5M59_RS17815	COG0564	pseudouridine synthase activity
I5M59_RS17820	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I5M59_RS17825	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I5M59_RS17835	COG1605	Chorismate mutase
I5M59_RS17835	COG0077	Prephenate dehydratase
I5M59_RS17845	COG0287	Prephenate dehydrogenase
I5M59_RS17845	COG1605	Chorismate mutase
I5M59_RS17850	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I5M59_RS17860	COG2199	diguanylate cyclase activity
I5M59_RS17865	COG2885	chlorophyll binding
I5M59_RS17900	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I5M59_RS17905	COG4137	Cytochrome C assembly protein
I5M59_RS17910	COG4536	flavin adenine dinucleotide binding
I5M59_RS17925	COG0497	DNA recombination
I5M59_RS17940	COG2867	negative regulation of translational initiation
I5M59_RS17970	COG2207	Transcriptional regulator
I5M59_RS17970	COG3708	Transcriptional regulator
I5M59_RS17975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M59_RS18010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M59_RS18020	COG0235	Class ii aldolase
I5M59_RS18030	COG1028	Short-chain dehydrogenase reductase Sdr
I5M59_RS18045	COG2197	response regulator
I5M59_RS18050	COG3539	Fimbrial protein
I5M59_RS18060	COG3188	usher protein
I5M59_RS18080	COG3121	Chaperone
I5M59_RS18085	COG3539	Fimbrial protein
I5M59_RS18095	COG3284	Transcriptional regulator
I5M59_RS18105	COG0583	DNA-binding transcription factor activity
I5M59_RS18115	COG0640	Transcriptional regulator
I5M59_RS18120	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5M59_RS18135	COG2916	Histone family protein nucleoid-structuring protein H-NS
I5M59_RS18150	COG4575	ribosome binding
I5M59_RS18155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5M59_RS18160	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5M59_RS18165	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I5M59_RS18175	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I5M59_RS18190	COG4176	ABC-type proline glycine betaine transport system permease component
I5M59_RS18200	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I5M59_RS18210	COG1846	Transcriptional regulator
I5M59_RS18215	COG1566	PFAM secretion protein HlyD family protein
I5M59_RS18220	COG2814	Major facilitator Superfamily
I5M59_RS18225	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I5M59_RS18245	COG1238	metal cluster binding
I5M59_RS18250	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5M59_RS18255	COG2823	Periplasmic or secreted lipoprotein
I5M59_RS18285	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I5M59_RS18305	COG1546	Belongs to the CinA family
I5M59_RS18310	COG0803	Belongs to the bacterial solute-binding protein 9 family
I5M59_RS18315	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5M59_RS18320	COG1121	(ABC) transporter
I5M59_RS18325	COG2951	lytic endotransglycosylase activity
I5M59_RS18330	COG3730	PTS system glucitol sorbitol-specific
I5M59_RS18335	COG3732	PTS system glucitol sorbitol-specific
I5M59_RS18345	COG1028	Short-chain dehydrogenase reductase Sdr
I5M59_RS18350	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M59_RS18355	COG1349	DNA-binding transcription factor activity
I5M59_RS18380	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
I5M59_RS18385	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I5M59_RS18390	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I5M59_RS18395	COG1609	Transcriptional regulator
I5M59_RS18400	COG1263	PTS System
I5M59_RS18400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5M59_RS18405	COG2723	6-phospho-beta-galactosidase activity
I5M59_RS18415	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I5M59_RS18425	COG3260	NADH ubiquinone oxidoreductase 20
I5M59_RS18430	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I5M59_RS18435	COG3261	NADH dehydrogenase
I5M59_RS18435	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I5M59_RS18440	COG0650	Formate hydrogenlyase subunit 4
I5M59_RS18445	COG0651	ATP synthesis coupled electron transport
I5M59_RS18450	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I5M59_RS18465	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I5M59_RS18470	COG0298	carbon dioxide binding
I5M59_RS18475	COG0409	Hydrogenase expression formation protein
I5M59_RS18480	COG0309	Hydrogenase expression formation protein (HypE)
I5M59_RS18490	COG2723	6-phospho-beta-galactosidase activity
I5M59_RS18500	COG4580	involved in the transport of maltose and maltodextrins
I5M59_RS18505	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M59_RS18510	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M59_RS18515	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M59_RS18520	COG1447	Phosphotransferase system cellobiose-specific component IIA
I5M59_RS18525	COG1940	carbohydrate kinase activity
I5M59_RS18530	COG1609	Transcriptional regulator
I5M59_RS18540	COG1121	(ABC) transporter
I5M59_RS18545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5M59_RS18550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5M59_RS18565	COG0679	Auxin Efflux Carrier
I5M59_RS18585	COG3720	iron ion transport
I5M59_RS18590	COG4558	Periplasmic binding protein
I5M59_RS18595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M59_RS18635	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I5M59_RS18640	COG0163	prenyltransferase activity
I5M59_RS18665	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I5M59_RS18670	COG4942	peptidase
I5M59_RS18670	COG1388	LysM domain
I5M59_RS18730	COG2234	aminopeptidase activity
I5M59_RS18750	COG0720	synthase
I5M59_RS18755	COG0602	queuosine metabolic process
I5M59_RS18775	COG3956	TIGRFAM MazG family protein
I5M59_RS18780	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I5M59_RS18790	COG3437	response regulator, receiver
I5M59_RS18790	COG2205	protein histidine kinase activity
I5M59_RS18790	COG4999	Histidine kinase
I5M59_RS18790	COG3850	Histidine kinase
I5M59_RS18795	COG1929	Belongs to the glycerate kinase type-1 family
I5M59_RS18800	COG4948	Mandelate Racemase Muconate Lactonizing
I5M59_RS18805	COG4948	Mandelate Racemase Muconate Lactonizing
I5M59_RS18810	COG2271	Major facilitator Superfamily
I5M59_RS18815	COG0716	FMN binding
I5M59_RS18820	COG0564	pseudouridine synthase activity
I5M59_RS18825	COG3098	single-species biofilm formation
I5M59_RS18840	COG1611	Belongs to the LOG family
I5M59_RS18845	COG0814	amino acid
I5M59_RS18850	COG1760	l-serine dehydratase
I5M59_RS18855	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5M59_RS18865	COG0477	Major facilitator Superfamily
I5M59_RS18870	COG1464	Belongs to the NlpA lipoprotein family
I5M59_RS18875	COG2011	ABC-type metal ion transport system permease component
I5M59_RS18880	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I5M59_RS18895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5M59_RS18915	COG1454	alcohol dehydrogenase
I5M59_RS18920	COG0235	Class ii aldolase
I5M59_RS18925	COG0738	Major facilitator superfamily
I5M59_RS18945	COG1349	DNA-binding transcription factor activity
I5M59_RS18955	COG2363	Small membrane protein
I5M59_RS18960	COG0583	DNA-binding transcription factor activity
I5M59_RS18970	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I5M59_RS18975	COG2166	iron-sulfur cluster assembly
I5M59_RS18980	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I5M59_RS18985	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I5M59_RS19150	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I5M59_RS19180	COG1012	belongs to the aldehyde dehydrogenase family
I5M59_RS19180	COG1454	alcohol dehydrogenase
I5M59_RS19185	COG4656	Part of a membrane complex involved in electron transport
I5M59_RS19215	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I5M59_RS19220	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5M59_RS19225	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I5M59_RS19225	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I5M59_RS19235	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I5M59_RS19240	COG1074	ATP-dependent DNA helicase activity
I5M59_RS19245	COG1025	Belongs to the peptidase M16 family
I5M59_RS19250	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I5M59_RS19255	COG4967	type IV pilus modification protein PilV
I5M59_RS19265	COG4795	General secretion pathway protein
I5M59_RS19270	COG2165	general secretion pathway protein
I5M59_RS19305	COG0861	Integral membrane protein TerC family
I5M59_RS19315	COG0667	Aldo Keto reductase
I5M59_RS19335	COG1609	Transcriptional regulator
I5M59_RS19345	COG2186	Transcriptional regulator
I5M59_RS19350	COG2723	6-phospho-beta-galactosidase activity
I5M59_RS19355	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M59_RS19360	COG1609	Transcriptional regulator
I5M59_RS19370	COG0583	DNA-binding transcription factor activity
I5M59_RS19375	COG1794	racemase activity, acting on amino acids and derivatives
I5M59_RS19380	COG1917	Cupin 2, conserved barrel domain protein
I5M59_RS19385	COG1175	transmembrane transport
I5M59_RS19390	COG0395	ABC-type sugar transport system, permease component
I5M59_RS19395	COG3842	ATPase activity
I5M59_RS19430	COG2814	Major facilitator Superfamily
I5M59_RS19435	COG1028	Short-chain dehydrogenase reductase Sdr
I5M59_RS19440	COG0823	Involved in the tonB-independent uptake of proteins
I5M59_RS19450	COG0183	Belongs to the thiolase family
I5M59_RS19465	COG0814	amino acid
I5M59_RS19470	COG0667	Aldo Keto reductase
I5M59_RS19525	COG1846	Transcriptional regulator
I5M59_RS19530	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I5M59_RS19535	COG0582	viral genome integration into host DNA
I5M59_RS19540	COG4974	Belongs to the 'phage' integrase family
I5M59_RS19550	COG3539	Fimbrial protein
I5M59_RS19555	COG3121	Chaperone
I5M59_RS19560	COG3188	usher protein
I5M59_RS19565	COG3539	Fimbrial protein
I5M59_RS19570	COG3539	Fimbrial protein
I5M59_RS19575	COG3539	Fimbrial protein
I5M59_RS19585	COG2388	GCN5-related N-acetyl-transferase
I5M59_RS19590	COG3592	Divergent 4Fe-4S mono-cluster
I5M59_RS19605	COG1289	transmembrane transporter activity
I5M59_RS19610	COG1538	Outer membrane efflux protein
I5M59_RS19625	COG1393	Belongs to the ArsC family
I5M59_RS19670	COG0667	Aldo Keto reductase
I5M59_RS19685	COG2814	Major facilitator Superfamily
I5M59_RS19695	COG4942	peptidase
I5M59_RS19715	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I5M59_RS19725	COG4974	Belongs to the 'phage' integrase family
I5M59_RS19730	COG0716	FMN binding
I5M59_RS19740	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I5M59_RS19750	COG1272	protein, Hemolysin III
I5M59_RS19760	COG1737	Transcriptional regulator
I5M59_RS19765	COG2723	6-phospho-beta-galactosidase activity
I5M59_RS19785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5M59_RS19790	COG1028	Short-chain dehydrogenase reductase Sdr
I5M59_RS19810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5M59_RS19815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5M59_RS19820	COG0006	proline dipeptidase activity
I5M59_RS19840	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I5M59_RS19845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5M59_RS19860	COG2968	Membrane
I5M59_RS19870	COG0668	transmembrane transport
I5M59_RS19875	COG0191	fructose-bisphosphate aldolase activity
I5M59_RS19890	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I5M59_RS19895	COG0501	Belongs to the peptidase M48B family
I5M59_RS19930	COG2814	Major facilitator Superfamily
I5M59_RS19940	COG2356	endonuclease I
I5M59_RS19945	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I5M59_RS19950	COG0189	ligase activity
I5M59_RS19970	COG2805	Type II/IV secretion system protein
I5M59_RS19975	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I5M59_RS19980	COG0762	integral membrane protein
I5M59_RS19995	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I5M59_RS20010	COG4214	carbohydrate transport
I5M59_RS20020	COG3171	Protein conserved in bacteria
I5M59_RS20030	COG1194	a g-specific adenine glycosylase
I5M59_RS20045	COG2211	Major facilitator Superfamily
I5M59_RS20050	COG1982	Orn Lys Arg decarboxylase major
I5M59_RS20055	COG1811	Na channel or pump
I5M59_RS20070	COG0626	cystathionine gamma-synthase activity
I5M59_RS20075	COG0583	DNA-binding transcription factor activity
I5M59_RS20095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5M59_RS20100	COG0754	glutathionylspermidine amidase activity
I5M59_RS20115	COG0625	glutathione transferase activity
I5M59_RS20140	COG2211	Major facilitator Superfamily
I5M59_RS20145	COG0848	biopolymer transport protein
I5M59_RS20155	COG0626	cystathionine gamma-synthase activity
I5M59_RS20160	COG0586	Pfam SNARE associated Golgi protein
I5M59_RS20165	COG2207	Transcriptional regulator
I5M59_RS20170	COG1979	alcohol dehydrogenase
I5M59_RS20175	COG0656	L-ascorbic acid biosynthetic process
I5M59_RS20185	COG1032	radical SAM domain protein
I5M59_RS20190	COG2132	Multicopper oxidase
I5M59_RS20195	COG0204	Acyl-transferase
I5M59_RS20200	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I5M59_RS20205	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I5M59_RS20210	COG3111	PFAM Bacterial OB fold (BOF) protein
I5M59_RS20220	COG0642	Histidine kinase
I5M59_RS20225	COG2249	NAD(P)H dehydrogenase (quinone) activity
I5M59_RS20230	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I5M59_RS20240	COG3150	esterase
I5M59_RS20245	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I5M59_RS20250	COG3151	Protein conserved in bacteria
I5M59_RS20255	COG0494	nUDIX hydrolase
I5M59_RS20270	COG0754	glutathionylspermidine amidase activity
I5M59_RS20275	COG3384	dioxygenase
I5M59_RS20290	COG2960	long-chain fatty acid transporting porin activity
I5M59_RS20315	COG3025	triphosphatase activity
I5M59_RS20320	COG4991	sh3 domain protein
I5M59_RS20335	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I5M59_RS20400	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I5M59_RS20405	COG0358	DNA primase activity
I5M59_RS20410	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I5M59_RS20435	COG2197	response regulator
I5M59_RS20440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M59_RS20440	COG0784	Response regulator, receiver
I5M59_RS20440	COG2205	protein histidine kinase activity
I5M59_RS20440	COG2198	Histidine kinase
I5M59_RS20450	COG3247	response to pH
I5M59_RS20520	COG2376	Dihydroxyacetone kinase
I5M59_RS20525	COG1461	Dihydroxyacetone kinase
I5M59_RS20540	COG2375	cellular response to nickel ion
I5M59_RS20545	COG1695	Transcriptional regulator
I5M59_RS20595	COG1902	pentaerythritol trinitrate reductase activity
I5M59_RS20595	COG0446	pyridine nucleotide-disulphide oxidoreductase
I5M59_RS20615	COG1451	nucleotide metabolic process
I5M59_RS20620	COG0673	inositol 2-dehydrogenase activity
I5M59_RS20625	COG0861	Integral membrane protein TerC family
I5M59_RS20640	COG2721	sulfolactate sulfo-lyase activity
I5M59_RS20650	COG2271	Major facilitator Superfamily
I5M59_RS20655	COG2186	Transcriptional regulator
I5M59_RS20660	COG0586	Pfam SNARE associated Golgi protein
I5M59_RS20670	COG1422	Protein of unknown function (DUF1090)
I5M59_RS20675	COG4575	ribosome binding
I5M59_RS20680	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I5M59_RS20690	COG2259	Doxx family
I5M59_RS20695	COG0435	Glutathione S-transferase
I5M59_RS20700	COG3152	Membrane
I5M59_RS20705	COG0583	DNA-binding transcription factor activity
I5M59_RS20710	COG1741	Belongs to the pirin family
I5M59_RS20735	COG1929	Belongs to the glycerate kinase type-1 family
I5M59_RS20740	COG2084	Dehydrogenase
I5M59_RS20750	COG2271	Major facilitator Superfamily
I5M59_RS20755	COG2721	sulfolactate sulfo-lyase activity
I5M59_RS20760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5M59_RS20765	COG1349	DNA-binding transcription factor activity
I5M59_RS20775	COG1105	Belongs to the carbohydrate kinase PfkB family
I5M59_RS20780	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M59_RS20780	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5M59_RS20780	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5M59_RS20785	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M59_RS20785	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M59_RS20795	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M59_RS20800	COG3414	Phosphotransferase system galactitol-specific IIB component
I5M59_RS20805	COG3775	system Galactitol-specific IIC component
I5M59_RS20810	COG1063	alcohol dehydrogenase
I5M59_RS20825	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I5M59_RS20845	COG2823	Periplasmic or secreted lipoprotein
I5M59_RS20850	COG0701	Predicted permease
I5M59_RS20855	COG0702	epimerase
I5M59_RS20860	COG0693	protein deglycase activity
I5M59_RS20875	COG3153	acetyltransferase
I5M59_RS20880	COG3154	lipid carrier protein
I5M59_RS20885	COG0826	peptidase U32
I5M59_RS20890	COG0826	peptidase U32
I5M59_RS20895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5M59_RS20900	COG0814	amino acid
I5M59_RS20945	COG0195	Participates in both transcription termination and antitermination
I5M59_RS20985	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I5M59_RS20995	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I5M59_RS21000	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I5M59_RS21010	COG1534	Rna-binding protein
I5M59_RS21020	COG2027	D-alanyl-D-alanine carboxypeptidase
I5M59_RS21030	COG0697	spore germination
I5M59_RS21045	COG0142	geranyltranstransferase activity
I5M59_RS21050	COG3423	Transcriptional regulator
I5M59_RS21060	COG5007	Belongs to the BolA IbaG family
I5M59_RS21065	COG3113	response to antibiotic
I5M59_RS21070	COG2854	intermembrane phospholipid transfer
I5M59_RS21075	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I5M59_RS21080	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I5M59_RS21085	COG1127	ABC transporter
I5M59_RS21090	COG0530	calcium, potassium:sodium antiporter activity
I5M59_RS21100	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I5M59_RS21105	COG3117	lipopolysaccharide transmembrane transporter activity
I5M59_RS21110	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I5M59_RS21115	COG1137	ATPase activity
I5M59_RS21120	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I5M59_RS21125	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I5M59_RS21130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M59_RS21140	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M59_RS21145	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I5M59_RS21150	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I5M59_RS21155	COG2198	Histidine kinase
I5M59_RS21155	COG5002	protein histidine kinase activity
I5M59_RS21155	COG0784	Response regulator, receiver
I5M59_RS21160	COG1312	Catalyzes the dehydration of D-mannonate
I5M59_RS21165	COG1063	alcohol dehydrogenase
I5M59_RS21170	COG2271	Major facilitator Superfamily
I5M59_RS21175	COG1242	4 iron, 4 sulfur cluster binding
I5M59_RS21180	COG0070	glutamate synthase
I5M59_RS21180	COG0069	glutamate synthase activity
I5M59_RS21180	COG0067	glutamate synthase
I5M59_RS21185	COG0493	'glutamate synthase
I5M59_RS21195	COG2969	positive regulation of protein catabolic process
I5M59_RS21200	COG0625	glutathione transferase activity
I5M59_RS21220	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I5M59_RS21225	COG3105	Protein conserved in bacteria
I5M59_RS21230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5M59_RS21235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5M59_RS21260	COG2732	(Barnase) inhibitor
I5M59_RS21265	COG1289	transmembrane transporter activity
I5M59_RS21280	COG0583	DNA-binding transcription factor activity
I5M59_RS21285	COG0312	modulator of DNA gyrase
I5M59_RS21290	COG3164	Protein of unknown function
I5M59_RS21295	COG1530	ribonuclease E activity
I5M59_RS21305	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I5M59_RS21310	COG1792	Involved in formation and maintenance of cell shape
I5M59_RS21315	COG1077	Cell shape determining protein MreB Mrl
I5M59_RS21320	COG2199	diguanylate cyclase activity
I5M59_RS21320	COG2200	EAL domain
I5M59_RS21345	COG0511	ligase activity, forming carbon-carbon bonds
I5M59_RS21350	COG0439	Biotin carboxylase
I5M59_RS21355	COG3924	membrane
I5M59_RS21360	COG4145	pantothenate transmembrane transporter activity
I5M59_RS21380	COG1309	transcriptional regulator
I5M59_RS21385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M59_RS21390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5M59_RS21425	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I5M59_RS21445	COG0551	DNA topoisomerase type I activity
I5M59_RS21455	COG0758	DNA mediated transformation
I5M59_RS21485	COG3036	rescue of stalled ribosome
I5M59_RS21490	COG0789	Transcriptional regulator
I5M59_RS21505	COG0202	RNA polymerase activity
I5M59_RS21530	COG0201	protein transport
I5M59_RS21595	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I5M59_RS21610	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I5M59_RS21635	COG0051	transcription antitermination factor activity, RNA binding
I5M59_RS21690	COG2964	Protein conserved in bacteria
I5M59_RS21695	COG0545	Peptidyl-prolyl cis-trans isomerase
I5M59_RS21705	COG1047	Peptidyl-prolyl cis-trans
I5M59_RS21710	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I5M59_RS21725	COG0488	(ABC) transporter
I5M59_RS21730	COG0429	hydrolase of the alpha beta-hydrolase fold
I5M59_RS21740	COG3954	Phosphoribulokinase
I5M59_RS21745	COG1765	OsmC-like protein
I5M59_RS21755	COG1289	transmembrane transporter activity
I5M59_RS21760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I5M59_RS21785	COG0738	Major facilitator superfamily
I5M59_RS21795	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I5M59_RS21820	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I5M59_RS21825	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I5M59_RS21830	COG3266	domain, Protein
I5M59_RS21845	COG4796	Type ii and iii secretion system protein
I5M59_RS21870	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I5M59_RS21875	COG0494	nUDIX hydrolase
I5M59_RS21885	COG1011	Hydrolase
I5M59_RS21890	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I5M59_RS21915	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I5M59_RS21920	COG2183	response to ionizing radiation
I5M59_RS21925	COG1918	ferrous iron import across plasma membrane
I5M59_RS21950	COG1040	competence protein
I5M59_RS21960	COG2610	gluconate transmembrane transporter activity
I5M59_RS21965	COG1640	4-alpha-glucanotransferase
I5M59_RS21970	COG0058	SHG alpha-glucan phosphorylase activity
I5M59_RS21980	COG1349	DNA-binding transcription factor activity
I5M59_RS21995	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I5M59_RS22010	COG0058	SHG alpha-glucan phosphorylase activity
I5M59_RS22035	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I5M59_RS22045	COG2610	gluconate transmembrane transporter activity
I5M59_RS22050	COG3265	gluconokinase activity
I5M59_RS22055	COG1609	Transcriptional regulator
I5M59_RS22060	COG1741	Belongs to the pirin family
I5M59_RS22065	COG0673	inositol 2-dehydrogenase activity
I5M59_RS22075	COG1247	-acetyltransferase
I5M59_RS22080	COG0405	Gamma-glutamyltransferase
I5M59_RS22090	COG0584	glycerophosphoryl diester phosphodiesterase
I5M59_RS22140	COG0559	Belongs to the binding-protein-dependent transport system permease family
I5M59_RS22145	COG0683	leucine binding
I5M59_RS22155	COG0683	leucine binding
I5M59_RS22165	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I5M59_RS22180	COG2177	Part of the ABC transporter FtsEX involved in
I5M59_RS22185	COG2884	Cell division ATP-binding protein ftsE
I5M59_RS22190	COG0552	protein localization to endoplasmic reticulum
I5M59_RS22195	COG0742	ribosomal rna small subunit methyltransferase
I5M59_RS22200	COG3776	membrane
I5M59_RS22210	COG3714	YhhN family
I5M59_RS22225	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I5M59_RS22235	COG0477	Major facilitator Superfamily
I5M59_RS22240	COG0628	permease
I5M59_RS22280	COG3479	Phenolic acid decarboxylase
I5M59_RS22290	COG0747	negative chemotaxis
I5M59_RS22295	COG0601	transmembrane transport
I5M59_RS22300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5M59_RS22310	COG1124	(ABC) transporter
I5M59_RS22320	COG2239	Acts as a magnesium transporter
I5M59_RS22325	COG2081	HI0933 family
I5M59_RS22330	COG0306	phosphate transporter
I5M59_RS22340	COG0589	response to stress
I5M59_RS22360	COG0671	phosphoesterase, PA-phosphatase related
I5M59_RS22365	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I5M59_RS22370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5M59_RS22380	COG1454	alcohol dehydrogenase
I5M59_RS22390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5M59_RS22395	COG1028	Short-chain dehydrogenase reductase Sdr
I5M59_RS22400	COG0583	DNA-binding transcription factor activity
I5M59_RS22405	COG1295	ribonuclease BN
I5M59_RS22410	COG0477	Major facilitator Superfamily
I5M59_RS22415	COG2982	Protein involved in outer membrane biogenesis
I5M59_RS22425	COG0612	Peptidase, M16
I5M59_RS22435	COG2200	EAL domain
I5M59_RS22435	COG2199	diguanylate cyclase activity
I5M59_RS22440	COG3118	belongs to the thioredoxin family
I5M59_RS22440	COG0457	Tetratricopeptide repeat
I5M59_RS22445	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I5M59_RS22450	COG1215	transferase activity, transferring glycosyl groups
I5M59_RS22480	COG2194	sulfuric ester hydrolase activity
I5M59_RS22495	COG0457	Tetratricopeptide repeat
I5M59_RS22500	COG1215	transferase activity, transferring glycosyl groups
I5M59_RS22510	COG2894	cell division
I5M59_RS22525	COG4608	Belongs to the ABC transporter superfamily
I5M59_RS22530	COG0444	Belongs to the ABC transporter superfamily
I5M59_RS22535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5M59_RS22540	COG0601	transmembrane transport
I5M59_RS22545	COG0747	negative chemotaxis
I5M59_RS22570	COG2223	nitrite transmembrane transporter activity
I5M59_RS22575	COG5571	outer membrane autotransporter
I5M59_RS22580	COG2818	Glycosylase
I5M59_RS22585	COG0456	acetyltransferase
I5M59_RS22590	COG0243	molybdopterin cofactor binding
I5M59_RS22595	COG2885	chlorophyll binding
I5M59_RS22600	COG1609	Transcriptional regulator
I5M59_RS22610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5M59_RS22630	COG2814	Major facilitator Superfamily
I5M59_RS22635	COG2944	sequence-specific DNA binding
I5M59_RS22640	COG1278	Cold shock
I5M59_RS22670	COG3274	enterobacterial common antigen metabolic process
I5M59_RS22675	COG4682	membrane
I5M59_RS22680	COG4682	membrane
I5M59_RS22695	COG4213	ABC transporter substrate-binding protein
I5M59_RS22705	COG4214	carbohydrate transport
I5M59_RS22710	COG2207	Transcriptional regulator
I5M59_RS22710	COG1609	Transcriptional regulator
I5M59_RS22715	COG2992	FlgJ-related protein
I5M59_RS22720	COG0366	Alpha amylase catalytic
I5M59_RS22725	COG3977	Valine--pyruvate aminotransferase
I5M59_RS22730	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I5M59_RS22735	COG1414	Transcriptional regulator
I5M59_RS22740	COG3276	selenocysteine insertion sequence binding
I5M59_RS22750	COG0625	glutathione transferase activity
I5M59_RS22755	COG1566	PFAM secretion protein HlyD family protein
I5M59_RS22775	COG3722	fumarate hydratase activity
I5M59_RS22790	COG1620	l-lactate permease
I5M59_RS22795	COG2186	Transcriptional regulator
I5M59_RS22805	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I5M59_RS22825	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I5M59_RS22830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5M59_RS22840	COG4942	peptidase
I5M59_RS22845	COG2861	carbohydrate metabolic process
I5M59_RS22850	COG0463	Glycosyl transferase, family 2
I5M59_RS22860	COG0156	8-amino-7-oxononanoate synthase activity
I5M59_RS22875	COG0859	PFAM glycosyl transferase family 9
I5M59_RS22900	COG0859	PFAM glycosyl transferase family 9
I5M59_RS22910	COG0438	transferase activity, transferring glycosyl groups
I5M59_RS22915	COG1216	Glycosyl transferase, family 2
I5M59_RS22920	COG1519	Transferase
I5M59_RS22955	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I5M59_RS22985	COG0842	Transport permease protein
I5M59_RS22990	COG1131	(ABC) transporter
I5M59_RS23010	COG1561	YicC-like family, N-terminal region
I5M59_RS23015	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I5M59_RS23020	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I5M59_RS23020	COG2169	Transcriptional regulator
I5M59_RS23030	COG2860	membrane
I5M59_RS23050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I5M59_RS23055	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I5M59_RS23060	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I5M59_RS23065	COG1494	fructose-1,6-bisphosphatase
I5M59_RS23075	COG3152	Membrane
I5M59_RS23100	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I5M59_RS23120	COG0786	glutamate:sodium symporter activity
I5M59_RS23125	COG2233	PERMEase
I5M59_RS23130	COG2982	Protein involved in outer membrane biogenesis
I5M59_RS23135	COG1263	PTS System
I5M59_RS23135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5M59_RS23140	COG1486	melibiose metabolic process
I5M59_RS23150	COG1501	Belongs to the glycosyl hydrolase 31 family
I5M59_RS23155	COG2211	Major facilitator Superfamily
I5M59_RS23210	COG1064	alcohol dehydrogenase
I5M59_RS23220	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I5M59_RS23235	COG1464	Belongs to the NlpA lipoprotein family
I5M59_RS23260	COG0583	DNA-binding transcription factor activity
I5M59_RS23295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5M59_RS23305	COG2814	Major facilitator Superfamily
I5M59_RS23315	COG1263	PTS System
I5M59_RS23315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5M59_RS23320	COG0697	spore germination
I5M59_RS23335	COG2828	Protein conserved in bacteria
I5M59_RS23340	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I5M59_RS23345	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I5M59_RS23350	COG0583	DNA-binding transcription factor activity
I5M59_RS23355	COG3384	dioxygenase
I5M59_RS23365	COG1609	Transcriptional regulator
I5M59_RS23375	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M59_RS23375	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M59_RS23380	COG1447	Phosphotransferase system cellobiose-specific component IIA
I5M59_RS23385	COG4580	involved in the transport of maltose and maltodextrins
I5M59_RS23410	COG2188	Transcriptional regulator
I5M59_RS23450	COG2271	Major facilitator Superfamily
I5M59_RS23460	COG2197	response regulator
I5M59_RS23465	COG0440	acetolactate synthase activity
I5M59_RS23470	COG0028	Belongs to the TPP enzyme family
I5M59_RS23500	COG2814	Major facilitator Superfamily
I5M59_RS23505	COG0583	DNA-binding transcription factor activity
I5M59_RS23515	COG2610	gluconate transmembrane transporter activity
I5M59_RS23535	COG2149	membrane
I5M59_RS23550	COG2188	Transcriptional regulator
I5M59_RS23560	COG3645	SOS response
I5M59_RS23575	COG5645	(Lipo)protein
I5M59_RS23580	COG0823	Involved in the tonB-independent uptake of proteins
I5M59_RS23585	COG2271	Major facilitator Superfamily
I5M59_RS23595	COG0800	Aldolase
I5M59_RS23600	COG3734	2-keto-3-deoxy-galactonokinase
I5M59_RS23605	COG2186	Transcriptional regulator
I5M59_RS23620	COG0561	phosphatase activity
I5M59_RS23625	COG0187	DNA topoisomerase II activity
I5M59_RS23655	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I5M59_RS23685	COG2091	lysine biosynthetic process via aminoadipic acid
I5M59_RS23690	COG0431	NADPH-dependent FMN reductase
I5M59_RS23695	COG2252	PERMEase
I5M59_RS23700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5M59_RS23705	COG0363	glucosamine-6-phosphate deaminase activity
I5M59_RS23710	COG2382	esterase
I5M59_RS23720	COG0704	Plays a role in the regulation of phosphate uptake
I5M59_RS23725	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I5M59_RS23730	COG0581	inorganic phosphate transmembrane transporter activity
I5M59_RS23735	COG0573	inorganic phosphate transmembrane transporter activity
I5M59_RS23740	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I5M59_RS23745	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I5M59_RS23795	COG3312	ion transport
I5M59_RS23810	COG0716	FMN binding
I5M59_RS23815	COG1522	sequence-specific DNA binding
I5M59_RS23845	COG1129	ABC transporter
I5M59_RS23850	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M59_RS23860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5M59_RS23865	COG1609	Transcriptional regulator
I5M59_RS23870	COG0477	Major facilitator Superfamily
I5M59_RS23875	COG2186	Transcriptional regulator
I5M59_RS23900	COG1763	Mo-molybdopterin cofactor biosynthetic process
I5M59_RS23910	COG3084	Protein conserved in bacteria
I5M59_RS23915	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I5M59_RS23925	COG0204	Acyl-transferase
I5M59_RS23945	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I5M59_RS23960	COG3852	Histidine kinase
I5M59_RS23975	COG1011	Hydrolase
I5M59_RS23990	COG0456	acetyltransferase
I5M59_RS24000	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I5M59_RS24015	COG2864	formate dehydrogenase
I5M59_RS24020	COG0437	4 iron, 4 sulfur cluster binding
I5M59_RS24065	COG2211	Major facilitator Superfamily
I5M59_RS24075	COG1454	alcohol dehydrogenase
I5M59_RS24080	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M59_RS24085	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M59_RS24090	COG1129	ABC transporter
I5M59_RS24130	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I5M59_RS24135	COG2258	MOSC domain
I5M59_RS24140	COG2205	protein histidine kinase activity
I5M59_RS24145	COG0745	RESPONSE REGULATOR receiver
I5M59_RS24150	COG3678	ATP-independent chaperone mediated protein folding
I5M59_RS24170	COG1575	Belongs to the MenA family. Type 1 subfamily
I5M59_RS24185	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I5M59_RS24190	COG1609	Transcriptional regulator
I5M59_RS24195	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I5M59_RS24210	COG0626	cystathionine gamma-synthase activity
I5M59_RS24215	COG0527	aspartate kinase activity
I5M59_RS24215	COG0460	homoserine dehydrogenase
I5M59_RS24225	COG0737	Belongs to the 5'-nucleotidase family
I5M59_RS24235	COG0583	DNA-binding transcription factor activity
I5M59_RS24245	COG0371	Dehydrogenase
I5M59_RS24255	COG2207	Transcriptional regulator
I5M59_RS24260	COG3443	Belongs to the bacterial solute-binding protein 9 family
I5M59_RS24275	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I5M59_RS24290	COG0583	DNA-binding transcription factor activity
I5M59_RS24365	COG3085	chromosome segregation
I5M59_RS24385	COG3978	acetolactate synthase activity
I5M59_RS24400	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I5M59_RS24405	COG0583	DNA-binding transcription factor activity
I5M59_RS24415	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5M59_RS24420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5M59_RS24430	COG1811	Na channel or pump
I5M59_RS24455	COG3118	belongs to the thioredoxin family
I5M59_RS24460	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I5M59_RS24465	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I5M59_RS24475	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I5M59_RS24480	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I5M59_RS24485	COG1088	dTDP-glucose 4,6-dehydratase activity
I5M59_RS24490	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I5M59_RS24495	COG0456	acetyltransferase
I5M59_RS24500	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I5M59_RS24505	COG2244	polysaccharide biosynthetic process
I5M59_RS24550	COG3071	HemY protein
I5M59_RS24555	COG2959	enzyme of heme biosynthesis
I5M59_RS24570	COG3072	Adenylate cyclase
I5M59_RS24600	COG1011	Hydrolase
I5M59_RS24605	COG0210	DNA helicase
I5M59_RS24635	COG1280	lysine exporter protein (LysE YggA)
I5M59_RS24645	COG1280	lysine exporter protein (LysE YggA)
I5M59_RS24650	COG2267	carboxylic ester hydrolase activity
I5M59_RS24655	COG0561	phosphatase activity
I5M59_RS24660	COG0697	spore germination
I5M59_RS24665	COG0583	DNA-binding transcription factor activity
I5M59_RS24685	COG2188	Transcriptional regulator
I5M59_RS24690	COG2149	membrane
I5M59_RS24700	COG0641	radical SAM
I5M59_RS24725	COG3165	ubiquinone biosynthetic process from chorismate
I5M59_RS24745	COG0805	protein transport
I5M59_RS24785	COG1739	Uncharacterized protein family UPF0029
I5M59_RS24795	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I5M59_RS24825	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I5M59_RS24870	COG0250	Participates in transcription elongation, termination and antitermination
I5M59_RS24905	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I5M59_RS24910	COG1447	Phosphotransferase system cellobiose-specific component IIA
I5M59_RS24920	COG3706	GGDEF domain
I5M59_RS24935	COG2104	thiamine diphosphate biosynthetic process
I5M59_RS24940	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I5M59_RS24955	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I5M59_RS24990	COG3678	ATP-independent chaperone mediated protein folding
I5M59_RS24995	COG4191	Histidine kinase
I5M59_RS25005	COG0151	Belongs to the GarS family
I5M59_RS25115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5M59_RS25320	COG1028	Short-chain dehydrogenase reductase Sdr
I5M59_RS25415	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5M59_RS25445	COG0740	serine-type endopeptidase activity
I5M59_RS25470	COG2390	Transcriptional regulator
I5M59_RS25475	COG0149	triose-phosphate isomerase activity
I5M59_RS25485	COG0698	ribose 5-phosphate isomerase
I5M59_RS25490	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I5M59_RS25495	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I5M59_RS25505	COG2271	Major facilitator Superfamily
I5M59_RS25510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I5M59_RS25550	COG0410	ABC transporter
I5M59_RS25555	COG1137	ATPase activity
I5M59_RS25700	COG0583	DNA-binding transcription factor activity
I5M59_RS25715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5M59_RS25720	COG0601	transmembrane transport
I5M59_RS25730	COG4172	Belongs to the ABC transporter superfamily
I5M59_RS25735	COG4948	Mandelate Racemase Muconate Lactonizing
I5M59_RS25750	COG1942	4-Oxalocrotonate Tautomerase
I5M59_RS25760	COG3039	Transposase
I5M59_RS25770	COG2205	protein histidine kinase activity
I5M59_RS25775	COG0745	RESPONSE REGULATOR receiver
I5M59_RS25780	COG1276	copper resistance
I5M59_RS25785	COG2372	response to copper ion
I5M59_RS25790	COG3667	copper resistance
I5M59_RS25795	COG2132	Multicopper oxidase
I5M59_RS25805	COG0739	heme binding
I5M59_RS25835	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M59_RS25920	COG0071	Belongs to the small heat shock protein (HSP20) family
I5M59_RS25925	COG0542	response to heat
I5M59_RS25945	COG0501	Belongs to the peptidase M48B family
I5M59_RS25980	COG1595	DNA-templated transcription, initiation
I5M59_RS25985	COG3712	iron ion homeostasis
I5M59_RS25990	COG4772	TonB-dependent receptor
I5M59_RS25995	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I5M59_RS26000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M59_RS26005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M59_RS26010	COG1120	ATPase activity
I5M59_RS26015	COG3436	PFAM IS66 Orf2 family protein
I5M59_RS26040	COG0640	Transcriptional regulator
I5M59_RS26045	COG0431	NADPH-dependent FMN reductase
I5M59_RS26080	COG1609	Transcriptional regulator
I5M59_RS26090	COG2223	nitrite transmembrane transporter activity
I5M59_RS26145	COG5654	RES domain protein
I5M59_RS26150	COG5642	Protein of unknown function (DUF2384)
I5M59_RS26185	COG3608	succinylglutamate desuccinylase aspartoacylase
I5M59_RS26190	COG0006	proline dipeptidase activity
I5M59_RS26195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5M59_RS26200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M59_RS26205	COG0765	amino acid transport
I5M59_RS26210	COG0765	amino acid transport
I5M59_RS26215	COG1126	abc transporter atp-binding protein
I5M59_RS26220	COG1126	abc transporter atp-binding protein
I5M59_RS26225	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I5M59_RS26230	COG2423	ornithine cyclodeaminase activity
I5M59_RS26240	COG3547	Transposase (IS116 IS110 IS902 family)
I5M59_RS26295	COG3547	Transposase (IS116 IS110 IS902 family)