locus-tag class description E4W57_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) E4W57_RS00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) E4W57_RS00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E4W57_RS00025 ENOG410667J hydrolase E4W57_RS00040 ENOG4105EMF GntR family transcriptional regulator E4W57_RS00045 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 E4W57_RS00050 ENOG4108RTU Aldolase E4W57_RS00055 ENOG4105CXK mandelate racemase muconate lactonizing E4W57_RS00060 ENOG4105DJB Major Facilitator Superfamily E4W57_RS00065 ENOG4105D99 atp gtp-binding protein E4W57_RS00070 ENOG4105R2A (LipO)protein E4W57_RS00085 ENOG4105F5P DNA-damage-inducible protein d E4W57_RS00090 ENOG4105D0C transport protein E4W57_RS00095 ENOG4105FDP GntR family transcriptional regulator E4W57_RS00100 ENOG4105CI1 PTS System E4W57_RS00105 ENOG4105F8D glycoside hydrolase family 4 E4W57_RS00110 ENOG4105VG5 Membrane E4W57_RS00115 ENOG4105JP4 Inner membrane protein yidG E4W57_RS00140 ENOG4105W8I Transcriptional regulator E4W57_RS00145 ENOG4105E5M Multidrug resistance protein D E4W57_RS00175 ENOG4105C7K acetolactate synthase E4W57_RS00180 ENOG4105M71 acetolactate synthase 1 regulatory subunit E4W57_RS00185 ENOG4108KX4 response regulator E4W57_RS00190 ENOG4105BZU Histidine kinase E4W57_RS00195 ENOG4105CXY transporter E4W57_RS00200 ENOG4105CXY transporter E4W57_RS00205 ENOG4108SAJ Protein of unknown function (DUF1198) E4W57_RS00225 ENOG4108KAZ Involved in phosphonate degradation (By similarity) E4W57_RS00230 ENOG4107STF Involved in phosphonate degradation (By similarity) E4W57_RS00235 ENOG4106S9K Transcriptional regulator E4W57_RS00250 ENOG4108MP3 ABC transporter, permease E4W57_RS00260 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) E4W57_RS00265 ENOG4105VCP PTS System E4W57_RS00270 ENOG4105CK1 PTS System E4W57_RS00280 ENOG4105ETE Transcriptional regulator (LacI family E4W57_RS00285 ENOG4105D2S major facilitator superfamily E4W57_RS00295 ENOG4107F9Y LysR family transcriptional regulator E4W57_RS00305 ENOG4105JSC dimethylmenaquinone methyltransferase E4W57_RS00320 ENOG4105T8A Uncharacterized protein YicS E4W57_RS00325 ENOG4108UZ3 Transporter E4W57_RS00330 ENOG4108EKE The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6-anhydro ring (By similarity) E4W57_RS00335 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate E4W57_RS00340 ENOG4105C2C drug resistance transporter, Bcr CflA E4W57_RS00345 ENOG4105ENJ RND efflux system, outer membrane lipoprotein E4W57_RS00350 ENOG4105BZS acriflavin resistance protein E4W57_RS00355 ENOG4105C1P efflux transporter, rnd family, mfp subunit E4W57_RS00375 ENOG410630P Transcriptional regulator E4W57_RS00385 ENOG4105CR8 Transcriptional regulator E4W57_RS00410 ENOG4105D01 (LipO)protein E4W57_RS00425 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein E4W57_RS00435 ENOG4105DQ4 alcohol dehydrogenase E4W57_RS00455 ENOG4105NI3 Protein of unknown function (DUF3237) E4W57_RS00470 ENOG4105CVR type I restriction-modification system E4W57_RS00475 ENOG4107XZC Restriction modification system DNA (Specificity E4W57_RS00505 ENOG4105DFP Integrase E4W57_RS00515 ENOG4105CT4 transporter E4W57_RS00520 ENOG4105CJQ hydrolase, family 31 E4W57_RS00530 ENOG4105F8D glycoside hydrolase family 4 E4W57_RS00535 ENOG4105CI1 PTS System E4W57_RS00540 ENOG4105JV1 AsmA family E4W57_RS00545 ENOG4105C2W permease E4W57_RS00550 ENOG4105D6U Sodium Glutamate Symporter E4W57_RS00555 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) E4W57_RS00560 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) E4W57_RS00565 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) E4W57_RS00570 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein E4W57_RS00585 ENOG4105CP7 Triose-phosphate isomerase E4W57_RS00590 ENOG4105EBK exported protein E4W57_RS00595 ENOG4108VTS Membrane E4W57_RS00600 ENOG4105DP0 ferredoxin-NADP reductase E4W57_RS00605 ENOG4105CBT Fructose-1,6-bisphosphatase E4W57_RS00610 ENOG4105CB5 ATP-dependent DNA helicase recG E4W57_RS00615 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase E4W57_RS00620 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) E4W57_RS00630 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) E4W57_RS00635 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) E4W57_RS00640 ENOG4105EN6 Membrane E4W57_RS00650 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) E4W57_RS00655 ENOG4108JZP Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate (By similarity) E4W57_RS00660 ENOG4105DSJ YicC domain protein E4W57_RS00680 ENOG4105CJ1 ABC, transporter E4W57_RS00690 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) E4W57_RS00705 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) E4W57_RS00710 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) E4W57_RS00715 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase E4W57_RS00720 ENOG4105W5Q DNA repair protein (RadC E4W57_RS00725 ENOG4105KDC 50s ribosomal protein l28 E4W57_RS00730 ENOG4105W0E 50S ribosomal protein L33 E4W57_RS00735 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) E4W57_RS00740 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) E4W57_RS00745 ENOG4106WTF Glycosyl transferase, family 2 E4W57_RS00750 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase E4W57_RS00755 ENOG4105K64 Glycosyl transferase, family 2 E4W57_RS00760 ENOG4105CPK Glycosyl transferase (Group 1 E4W57_RS00770 ENOG4105DKP glycosyl transferase, family 9 E4W57_RS00795 ENOG4105D16 lipopolysaccharide heptosyltransferase i E4W57_RS00800 ENOG4105XA0 heptosyltransferase ii E4W57_RS00805 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) E4W57_RS00810 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) E4W57_RS00815 ENOG4105CPQ Dehydrogenase E4W57_RS00820 ENOG4106WTF Glycosyl transferase, family 2 E4W57_RS00825 ENOG4105PXI polysaccharide deacetylase E4W57_RS00830 ENOG41063SB peptidase E4W57_RS00840 ENOG4107YZP Rhodanese domain protein E4W57_RS00845 ENOG4105VW4 glutaredoxin 3 E4W57_RS00850 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) E4W57_RS00855 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase E4W57_RS00860 ENOG4105D7W serine acetyltransferase E4W57_RS00865 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) E4W57_RS00870 ENOG4105DMF Dehydrogenase E4W57_RS00875 ENOG41073TP transcriptional regulator E4W57_RS00880 ENOG4105DAA L-lactate E4W57_RS00885 ENOG4108YYI Protein of unknown function (DUF2810) E4W57_RS00895 ENOG4105E61 Mannitol repressor protein E4W57_RS00900 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase E4W57_RS00905 ENOG4105CTS PTS system mannitol-specific E4W57_RS00910 ENOG4108U78 Glutathione S-transferase E4W57_RS00915 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) E4W57_RS00920 ENOG4105EM7 Selenocysteine-specific translation elongation factor E4W57_RS00925 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase E4W57_RS00930 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase E4W57_RS00935 ENOG4105H6Q decarboxylase E4W57_RS00940 ENOG4105CMG Carbohydrate kinase E4W57_RS00945 ENOG4105DJB Major Facilitator Superfamily E4W57_RS00955 ENOG4108R66 Conserved Protein E4W57_RS00965 ENOG4105J4Q Transcriptional regulator E4W57_RS00970 ENOG4108RC0 Electron transport protein E4W57_RS00975 ENOG4105JKW Valine--pyruvate aminotransferase E4W57_RS00980 ENOG4107T9C Alpha amylase catalytic region E4W57_RS00985 ENOG4108UR8 BAX protein E4W57_RS00990 ENOG4105T16 Transcriptional regulator (AraC family) E4W57_RS00995 ENOG4108HWW ABC transporter E4W57_RS01005 ENOG4105DFW ABC transporter E4W57_RS01010 ENOG4105C93 Xylose Isomerase E4W57_RS01015 ENOG4105CMG Carbohydrate kinase E4W57_RS01020 ENOG410688U Inner membrane protein yiaB E4W57_RS01025 ENOG4108Z12 YiaAB two helix domain-containing protein E4W57_RS01030 ENOG4105MEV Acyl-transferase E4W57_RS01040 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit E4W57_RS01045 ENOG4105C38 Glycyl-tRNA synthetase beta subunit E4W57_RS01050 ENOG41060TC Hok gef cell toxic protein E4W57_RS01055 ENOG4105C5H ABC transporter E4W57_RS01065 ENOG4105MVF Transcriptional regulator E4W57_RS01070 ENOG4105D2S major facilitator superfamily E4W57_RS01075 ENOG4106JH6 (LipO)protein E4W57_RS01080 ENOG4105C5I Dehydrogenase E4W57_RS01090 ENOG4105D7K pfkb domain protein E4W57_RS01100 ENOG4108M60 Transcriptional regulator E4W57_RS01105 ENOG4108ZG0 Ompa motb domain protein E4W57_RS01110 ENOG4107QY8 reductase E4W57_RS01115 ENOG4105HNP -acetyltransferase E4W57_RS01120 ENOG4108R3E Dna-3-methyladenine glycosylase i E4W57_RS01125 ENOG4105EAX Putative lipase E4W57_RS01130 ENOG4105FCD Major Facilitator E4W57_RS01135 ENOG4105DIJ Phosphoethanolamine transferase E4W57_RS01155 ENOG4105DEF Extracellular solute-binding protein, family 5 E4W57_RS01160 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component E4W57_RS01165 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component E4W57_RS01170 ENOG4105C3U ABC transporter E4W57_RS01175 ENOG4108JQ7 (ABC) transporter E4W57_RS01190 ENOG4107U53 septum site-determining protein minD E4W57_RS01195 ENOG4107QZ7 Cellulose synthase catalytic subunit E4W57_RS01200 ENOG4107EEX Cellulose synthase regulator protein E4W57_RS01205 ENOG4105EJG cellulose synthase E4W57_RS01220 ENOG4105D1V cellulose synthase operon protein YhjU E4W57_RS01225 ENOG410675P Celllulose biosynthesis operon protein BcsF YhjT E4W57_RS01230 ENOG4105U74 cellulose biosynthesis protein BcsE E4W57_RS01235 ENOG410661M cytoplasmic protein E4W57_RS01240 ENOG4105UTS cellulose synthase operon protein YhjQ E4W57_RS01245 ENOG4107QZ7 Cellulose synthase catalytic subunit E4W57_RS01250 ENOG4107EEX Cellulose synthase regulator protein E4W57_RS01255 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) E4W57_RS01260 ENOG4105EJG cellulose synthase E4W57_RS01265 ENOG4105BZU Histidine kinase E4W57_RS01270 ENOG4105CK2 sodium dicarboxylate symporter E4W57_RS01275 ENOG4105CS0 peptidase E4W57_RS01285 ENOG41066T0 asmA family E4W57_RS01290 ENOG4105CSH Transporter E4W57_RS01295 ENOG4107H3J ribonuclease E4W57_RS01300 ENOG4105CBN LysR family transcriptional regulator E4W57_RS01305 ENOG4105CHR reductase E4W57_RS01320 ENOG4105C0A alcohol dehydrogenase E4W57_RS01330 ENOG4105DC8 reductase E4W57_RS01335 ENOG4105D6S protein involved in catabolism of external DNA E4W57_RS01340 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase E4W57_RS01345 ENOG4105DGW oligopeptidase A E4W57_RS01350 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) E4W57_RS01355 ENOG4105DUX Transporter E4W57_RS01365 ENOG4108V6B universal stress protein B E4W57_RS01370 ENOG4105CJ3 phosphate transporter E4W57_RS01375 ENOG4105CBX hi0933 family E4W57_RS01380 ENOG4105CJW magnesium transporter E4W57_RS01390 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) E4W57_RS01400 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component E4W57_RS01405 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component E4W57_RS01410 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein E4W57_RS01420 ENOG4105PY6 Phenolic acid decarboxylase E4W57_RS01425 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase E4W57_RS01430 ENOG4105CKK Glycosyl transferase, family 2 E4W57_RS01435 ENOG4105C3I Nad-dependent epimerase dehydratase E4W57_RS01440 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) E4W57_RS01445 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) E4W57_RS01450 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) E4W57_RS01455 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) E4W57_RS01460 ENOG4105DSF transport protein E4W57_RS01465 ENOG4105F9N Major Facilitator Superfamily E4W57_RS01470 ENOG4108W1V Lipoprotein E4W57_RS01475 ENOG4105EX9 Membrane E4W57_RS01480 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) E4W57_RS01490 ENOG4107FS9 Membrane E4W57_RS01500 ENOG4105MG3 Membrane E4W57_RS01505 ENOG4106H78 methyltransferase E4W57_RS01510 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) E4W57_RS01515 ENOG4105CAK Cell division ATP-binding protein ftsE E4W57_RS01520 ENOG4105CRP Part of the ABC transporter FtsEX involved in E4W57_RS01535 ENOG4108JPW Aminotransferase E4W57_RS01545 ENOG4105CP9 extracellular ligand-binding receptor E4W57_RS01550 ENOG4105U59 -acetyltransferase E4W57_RS01555 ENOG4105CP9 extracellular ligand-binding receptor E4W57_RS01560 ENOG4105C32 Amino acid ABC transporter (Permease) E4W57_RS01565 ENOG4105CF8 branched-chain amino acid ABC transporter, permease E4W57_RS01570 ENOG4105C0Z ABC transporter E4W57_RS01575 ENOG4108IV0 ABC, transporter E4W57_RS01580 ENOG41060M8 Pfam:PhdYeFM E4W57_RS01590 ENOG4105BZ7 extracellular solute-binding protein family 1 E4W57_RS01595 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component E4W57_RS01610 ENOG4107T6V glycerophosphoryl diester phosphodiesterase E4W57_RS01615 ENOG4105WC8 Conserved Protein E4W57_RS01620 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) E4W57_RS01625 ENOG4105WCN acetyltransferase E4W57_RS01635 ENOG4105D9R oxidoreductase E4W57_RS01640 ENOG4105C2I pirin domain protein E4W57_RS01645 ENOG4105DIQ Transcriptional regulator E4W57_RS01650 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family E4W57_RS01655 ENOG4105C6Z Gluconate E4W57_RS01665 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) E4W57_RS01670 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) E4W57_RS01675 ENOG4108IUM Glycogen debranching enzyme E4W57_RS01680 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) E4W57_RS01685 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) E4W57_RS01690 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) E4W57_RS01705 ENOG4105C6V Glycerol-3-phosphate dehydrogenase E4W57_RS01710 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) E4W57_RS01715 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) E4W57_RS01720 ENOG4105E98 transcriptional regulator DeoR family E4W57_RS01725 ENOG41061ZR Transcriptional regulator E4W57_RS01730 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) E4W57_RS01735 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) E4W57_RS01740 ENOG4105C6Z Gluconate E4W57_RS01745 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) E4W57_RS01750 ENOG4105MJ2 Competence protein E4W57_RS01755 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) E4W57_RS01765 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) E4W57_RS01770 ENOG4105CE1 Ferrous iron transport protein b E4W57_RS01775 ENOG4105XFK Ferrous iron transport protein A E4W57_RS01780 ENOG4105BZM domain protein E4W57_RS01785 ENOG4108RRZ Transcription elongation factor GreB E4W57_RS01795 ENOG4105E0F Histidine kinase E4W57_RS01810 ENOG4105VEJ Heat shock protein E4W57_RS01815 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 E4W57_RS01820 ENOG4105DQY intracellular growth attenuator E4W57_RS01825 ENOG4107RK2 ADP-ribose diphosphatase NudE E4W57_RS01830 ENOG4108JQC penicillin-binding protein 1A E4W57_RS01855 ENOG4105E4G Type IV pilus E4W57_RS01860 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) E4W57_RS01865 ENOG4105D49 3-dehydroquinate synthase E4W57_RS01870 ENOG4105EGB membrane protein DamX E4W57_RS01875 ENOG4105DFE Dna adenine methylase E4W57_RS01880 ENOG4105DJV ribulose-phosphate 3-epimerase E4W57_RS01890 ENOG4105C31 Tryptophanyl-tRNA synthetase E4W57_RS01895 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) E4W57_RS01900 ENOG4105WZK nitrite reductase NADPH small subunit E4W57_RS01905 ENOG4107QZF nitrite reductase NADPH large subunit E4W57_RS01910 ENOG4105DZC cytosine deaminase E4W57_RS01915 ENOG4106DTQ Protein TsgA homolog E4W57_RS01920 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) E4W57_RS01925 ENOG4106195 uncharacterized protein yhfG E4W57_RS01930 ENOG4105MZU cell filamentation protein E4W57_RS01940 ENOG4105C8Y Acetylornithine aminotransferase E4W57_RS01945 ENOG410613R integral membrane protein, YccS YhfK family E4W57_RS01950 ENOG4107RYR Transcriptional regulator, Crp Fnr family E4W57_RS01955 ENOG4108UKZ OsmC family E4W57_RS01960 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) E4W57_RS01970 ENOG4105DNZ Alpha Beta Hydrolase E4W57_RS01975 ENOG4105C5H ABC transporter E4W57_RS01980 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein E4W57_RS01985 ENOG4105CKD glutathione-regulated potassium-efflux system protein E4W57_RS01990 ENOG4105VKU nucleicacid-binding protein E4W57_RS01995 ENOG4108YZY peptidylprolyl cis-trans isomerase E4W57_RS02000 ENOG4105VRX Protein slyX homolog E4W57_RS02005 ENOG4108V1T peptidylprolyl cis-trans isomerase E4W57_RS02010 ENOG4105WWK YheO domain protein E4W57_RS02015 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) E4W57_RS02020 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) E4W57_RS02025 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) E4W57_RS02030 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) E4W57_RS02035 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) E4W57_RS02040 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) E4W57_RS02045 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) E4W57_RS02050 ENOG4105W53 bacterioferritin-associated ferredoxin E4W57_RS02055 ENOG4108UQY Iron-storage protein E4W57_RS02070 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) E4W57_RS02075 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) E4W57_RS02085 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity E4W57_RS02090 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) E4W57_RS02095 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) E4W57_RS02100 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) E4W57_RS02105 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) E4W57_RS02110 ENOG41083MP 50s ribosomal protein l29 E4W57_RS02115 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal E4W57_RS02120 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) E4W57_RS02125 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) E4W57_RS02140 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) E4W57_RS02145 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) E4W57_RS02155 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) E4W57_RS02160 ENOG4105VPB 50S ribosomal protein L30 E4W57_RS02165 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) E4W57_RS02170 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) E4W57_RS02175 ENOG41067V7 50S ribosomal protein L36 E4W57_RS02180 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits E4W57_RS02185 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) E4W57_RS02190 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) E4W57_RS02195 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) E4W57_RS02200 ENOG4108ZT0 50S ribosomal protein l17 E4W57_RS02205 ENOG4105VTS DnaJ-like, subfamily C E4W57_RS02210 ENOG4105W1Y Transcriptional regulator E4W57_RS02215 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system E4W57_RS02220 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) E4W57_RS02225 ENOG4105C1A potassium transporter peripheral membrane E4W57_RS02230 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B E4W57_RS02235 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) E4W57_RS02240 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) E4W57_RS02245 ENOG4105C79 DNA protecting protein DprA E4W57_RS02255 ENOG4108WI1 Dna topoisomerase E4W57_RS02260 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) E4W57_RS02265 ENOG4105E2X shikimate dehydrogenase E4W57_RS02270 ENOG4105SG3 Protein of unknown function (DUF1488) E4W57_RS02275 ENOG4108Z0R Transferase E4W57_RS02305 ENOG4105XCM membrane LIPOPROTEIN E4W57_RS02310 ENOG4105BZS acriflavin resistance protein E4W57_RS02315 ENOG4105C1P efflux transporter, rnd family, mfp subunit E4W57_RS02320 ENOG4108XG4 DNA-binding transcriptional regulator E4W57_RS02330 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) E4W57_RS02335 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) E4W57_RS02340 ENOG4108IA2 Sodium pantothenate symporter E4W57_RS02345 ENOG4105RG0 Membrane E4W57_RS02350 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase E4W57_RS02355 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein E4W57_RS02365 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) E4W57_RS02380 ENOG41062P1 Diguanylate cyclase phosphodiesterase E4W57_RS02390 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) E4W57_RS02395 ENOG4105VQ7 Rod shape-determining protein MreD E4W57_RS02400 ENOG4108Z03 MAF-like protein E4W57_RS02405 ENOG4105C03 ribonuclease E4W57_RS02410 ENOG4105QD6 exported protein E4W57_RS02415 ENOG4105D1U peptidase U62 modulator of DNA gyrase E4W57_RS02420 ENOG4105CR8 Transcriptional regulator E4W57_RS02435 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) E4W57_RS02440 ENOG4105UNR (Barnase) inhibitor E4W57_RS02445 ENOG4105RID UPF0379 protein yhcN E4W57_RS02450 ENOG4105RID UPF0379 protein yhcN E4W57_RS02455 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) E4W57_RS02460 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) E4W57_RS02465 ENOG4105C0H protease E4W57_RS02470 ENOG4105C0H protease E4W57_RS02475 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III E4W57_RS02480 ENOG4105D6Z AFG1 family ATPase E4W57_RS02485 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) E4W57_RS02500 ENOG4107MKT Stringent starvation protein a E4W57_RS02505 ENOG4105KB2 stringent starvation protein b E4W57_RS02515 ENOG4105BZ8 glutamate synthase E4W57_RS02520 ENOG4105CBC glutamate synthase E4W57_RS02525 ENOG4105N5T Radical SAM Protein E4W57_RS02530 ENOG4108I5G Major Facilitator superfamily E4W57_RS02535 ENOG4105CPQ Dehydrogenase E4W57_RS02540 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) E4W57_RS02545 ENOG4105BZU Histidine kinase E4W57_RS02550 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain E4W57_RS02560 ENOG41080Z8 PHOSPHOCARRIER protein E4W57_RS02565 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) E4W57_RS02570 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN E4W57_RS02575 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA E4W57_RS02580 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E4W57_RS02585 ENOG4108IUZ ABC transporter E4W57_RS02590 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA E4W57_RS02595 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) E4W57_RS02600 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase E4W57_RS02605 ENOG4105C2X Arabinose 5-phosphate isomerase E4W57_RS02610 ENOG4105FEU K -dependent Na -Ca exchanger E4W57_RS02615 ENOG4105DHJ ABC, transporter E4W57_RS02620 ENOG4105CY3 ABC transporter, permease E4W57_RS02625 ENOG4107PE3 Mammalian cell entry related domain protein E4W57_RS02630 ENOG4105E3I toluene tolerance E4W57_RS02635 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane E4W57_RS02640 ENOG4105VFK BolA family E4W57_RS02645 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) E4W57_RS02650 ENOG4105HVQ Regulatory factor of maltose metabolism E4W57_RS02655 ENOG4105EAH synthase E4W57_RS02660 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) E4W57_RS02665 ENOG4105K46 50S ribosomal protein l27 E4W57_RS02670 ENOG4105QYV Membrane E4W57_RS02675 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control E4W57_RS02680 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase E4W57_RS02685 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) E4W57_RS02690 ENOG4105HBR Rna-binding protein E4W57_RS02695 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) E4W57_RS02700 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) E4W57_RS02705 ENOG4105EEI dihydropteroate synthase E4W57_RS02710 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) E4W57_RS02715 ENOG4105NTZ Preprotein translocase subunit SecG E4W57_RS02730 ENOG4108UII YfaZ family E4W57_RS02735 ENOG4108PNB DNA-binding transcriptional regulator E4W57_RS02740 ENOG4105CDH Citrulline--aspartate ligase E4W57_RS02750 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) E4W57_RS02755 ENOG4105CHV Transcription elongation factor NusA E4W57_RS02760 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) E4W57_RS02765 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) E4W57_RS02770 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) E4W57_RS02775 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) E4W57_RS02780 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) E4W57_RS02795 ENOG4105C1J atp-dependent rna helicase E4W57_RS02800 ENOG4105CIC tryptophan-specific transport protein E4W57_RS02805 ENOG4105DEN Luciferase family E4W57_RS02825 ENOG4108YYD acetyltransferase E4W57_RS02830 ENOG41082IR Excinuclease ABC C subunit domain protein E4W57_RS02835 ENOG4108ZPB UPF0306 protein E4W57_RS02840 ENOG4107R7Y intracellular protease Pfpi family E4W57_RS02845 ENOG4105K4T epimerase E4W57_RS02850 ENOG4107S21 permease E4W57_RS02855 ENOG4105W4M Transport-associated protein E4W57_RS02860 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) E4W57_RS02865 ENOG41082RQ UPF0102 protein E4W57_RS02870 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) E4W57_RS02875 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) E4W57_RS02880 ENOG4105CTX dehydratase E4W57_RS02885 ENOG4105DJB Major Facilitator Superfamily E4W57_RS02890 ENOG4105CNV Aldolase E4W57_RS02895 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase E4W57_RS02900 ENOG4105BZW Glycerate kinase E4W57_RS02920 ENOG4106D80 Uncharacterized protein YhaL E4W57_RS02925 ENOG4108CNN domain protein E4W57_RS02930 ENOG4105CWB LysR family transcriptional Regulator E4W57_RS02935 ENOG4105KAF membrAne E4W57_RS02940 ENOG4105CHF Glutathione S-transferase E4W57_RS02945 ENOG4108VBZ doxx family E4W57_RS02950 ENOG4105YJD E4W57_RS02955 ENOG41090KG Inner membrane protein YqjE E4W57_RS02960 ENOG4105NE1 Conserved Protein E4W57_RS02965 ENOG4105WAY exported protein E4W57_RS02970 ENOG4105VD9 Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) E4W57_RS02975 ENOG4106W5V Membrane E4W57_RS02980 ENOG4107YCY Transcriptional regulator E4W57_RS02985 ENOG4105DPW Major facilitator superfamily MFS_1 E4W57_RS02995 ENOG4105CTX dehydratase E4W57_RS03000 ENOG4105P66 Membrane E4W57_RS03005 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) E4W57_RS03010 ENOG4105DU1 integral membrane protein, terc E4W57_RS03015 ENOG4105EE0 oxidoreductase E4W57_RS03020 ENOG4108VKG metal-dependent hydrolase E4W57_RS03040 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E4W57_RS03045 ENOG4107RYS Autoinducer-2 (AI-2) kinase E4W57_RS03050 ENOG4105DKT Transcriptional regulator E4W57_RS03055 ENOG4105C2J ABC transporter E4W57_RS03060 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane E4W57_RS03065 ENOG4105F5R ABC transporter E4W57_RS03070 ENOG4105D4B ABC, transporter E4W57_RS03075 ENOG41061GT Aldolase E4W57_RS03080 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound E4W57_RS03085 ENOG4105C8Y Acetylornithine aminotransferase E4W57_RS03090 ENOG4105NTW Transcriptional regulator E4W57_RS03095 ENOG4105Q26 Siderophore-interacting protein E4W57_RS03110 ENOG4108UTZ Dihydroxyacetone kinase E4W57_RS03115 ENOG4105CMT Dihydroxyacetone kinase E4W57_RS03145 ENOG4105C0A alcohol dehydrogenase E4W57_RS03160 ENOG4105YCI dehydratase medium subunit E4W57_RS03165 ENOG4108ZFT Dehydratase small subunit E4W57_RS03170 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit E4W57_RS03175 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) E4W57_RS03180 ENOG4105XXV Acid-resistance protein E4W57_RS03185 ENOG4108YK4 Acid-resistance membrane protein E4W57_RS03190 ENOG4108V08 YfdX protein E4W57_RS03195 ENOG4105BZU Histidine kinase E4W57_RS03200 ENOG4108WQH regulatoR E4W57_RS03220 ENOG4108VCA G U mismatch-specific DNA glycosylase E4W57_RS03225 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E4W57_RS03230 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) E4W57_RS03240 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) E4W57_RS03250 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) E4W57_RS03255 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) E4W57_RS03260 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) E4W57_RS03265 ENOG4105CQM Urea amidohydrolase subunit alpha E4W57_RS03270 ENOG4105KI2 Urea amidohydrolase subunit beta E4W57_RS03275 ENOG4108YZ9 Urea amidohydrolase subunit gamma E4W57_RS03280 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) E4W57_RS03295 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) E4W57_RS03300 ENOG4107ZVW dihydroneopterin aldolase E4W57_RS03305 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) E4W57_RS03310 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate E4W57_RS03315 ENOG4106MWK domain protein E4W57_RS03320 ENOG4105I7R Adenylate cyclase E4W57_RS03325 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) E4W57_RS03330 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) E4W57_RS03345 ENOG4105W0Z cytoplasmic protein E4W57_RS03350 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) E4W57_RS03360 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b E4W57_RS03365 ENOG4106032 Glutathionylspermidine synthase E4W57_RS03370 ENOG4105F1G UPF0441 protein E4W57_RS03380 ENOG41087AY ADP-Ribose pyrophosphatase E4W57_RS03385 ENOG4108SX3 cytoplasmic protein E4W57_RS03390 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) E4W57_RS03395 ENOG4105IPS esterase E4W57_RS03400 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E4W57_RS03405 ENOG4105VRH Antibiotic biosynthesis monooxygenase E4W57_RS03410 ENOG4105NF4 modulator of drug activity E4W57_RS03415 ENOG4105DHQ Histidine kinase E4W57_RS03420 ENOG4105XJC Two component transcriptional regulator (Winged helix family E4W57_RS03425 ENOG4105H4F exported protein E4W57_RS03430 ENOG4105F4I Transcriptional regulator E4W57_RS03435 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E4W57_RS03440 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase E4W57_RS03445 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) E4W57_RS03450 ENOG4105CCT upf0313 protein E4W57_RS03460 ENOG4105CV8 reductase E4W57_RS03465 ENOG4108I6A alcohol dehydrogenase E4W57_RS03470 ENOG4105CF7 AraC family transcriptional regulator E4W57_RS03475 ENOG4108K81 inner membrane protein YghB E4W57_RS03480 ENOG4105C28 cystathionine E4W57_RS03485 ENOG4105CWK Biopolymer transport protein, ExbB E4W57_RS03490 ENOG4108ZZF transport protein (ExbD) E4W57_RS03495 ENOG4105CT4 transporter E4W57_RS03500 ENOG4105E4I Glycoside hydrolase family 28 E4W57_RS03505 ENOG4108TEB UPF0114 protein E4W57_RS03515 ENOG410900S Protein of unknown function (DUF2623) E4W57_RS03520 ENOG4105CYM Glutathione S-transferase E4W57_RS03535 ENOG4106032 Glutathionylspermidine synthase E4W57_RS03540 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family E4W57_RS03560 ENOG4105CC0 LysR family Transcriptional regulator E4W57_RS03565 ENOG4105C28 cystathionine E4W57_RS03600 ENOG4108UQV Membrane E4W57_RS03605 ENOG4105CXN decarboxylase E4W57_RS03610 ENOG4105EAA nucleoside E4W57_RS03615 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division E4W57_RS03620 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) E4W57_RS03625 ENOG4105CEN a g-specific adenine glycosylase E4W57_RS03630 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) E4W57_RS03635 ENOG41090ED Protein with unknown function (DUF469) E4W57_RS03640 ENOG4105K33 Periplasmic Protein E4W57_RS03650 ENOG4105CG6 trap dicarboxylate transporter dctm subunit E4W57_RS03655 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit E4W57_RS03660 ENOG4105CSA Coproporphyrinogen iii oxidase E4W57_RS03665 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) E4W57_RS03670 ENOG4105VZ9 UPF0235 protein E4W57_RS03675 ENOG4108VIA integral membrane protein E4W57_RS03680 ENOG4105DFA alanine racemase domain protein E4W57_RS03685 ENOG4105CZX twitching motility protein E4W57_RS03690 ENOG41086KC Transcriptional regulator E4W57_RS03695 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) E4W57_RS03700 ENOG4108UJU UPF0301 protein E4W57_RS03705 ENOG4105D7Z glutathione synthase E4W57_RS03710 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) E4W57_RS03715 ENOG4105RWS endonuclease I E4W57_RS03720 ENOG4105GPY SprT protein E4W57_RS03725 ENOG4107QNK )-transporter E4W57_RS03730 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP E4W57_RS03750 ENOG4105CYW agmatinase E4W57_RS03775 ENOG4105CHR reductase E4W57_RS03780 ENOG4108FUF Transcriptional regulator, IclR family E4W57_RS03790 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase E4W57_RS03810 ENOG4105CHR reductase E4W57_RS03815 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) E4W57_RS03830 ENOG4105J5J Outer membrane porin E4W57_RS03835 ENOG4108K0D peptidase, M48 E4W57_RS03840 ENOG4105CV1 Transketolase (EC 2.2.1.1) E4W57_RS03845 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase E4W57_RS03855 ENOG4105D2N Aldolase E4W57_RS03860 ENOG4105D64 Mechanosensitive ion channel E4W57_RS03865 ENOG4108ZUB Lysine exporter protein (Lyse ygga) E4W57_RS03870 ENOG4105MPN Membrane E4W57_RS03875 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) E4W57_RS03880 ENOG4105E66 phosphoriboisomerase A E4W57_RS03885 ENOG4108JQ1 Dehydrogenase E4W57_RS03890 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase E4W57_RS03900 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) E4W57_RS03905 ENOG4105E07 UPF0149 protein E4W57_RS03910 ENOG4107RAQ aminopeptidase E4W57_RS03915 ENOG4105D0A hydroxylase E4W57_RS03920 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family E4W57_RS03925 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) E4W57_RS03930 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) E4W57_RS03935 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor E4W57_RS03940 ENOG4105CYX Short-chain dehydrogenase reductase Sdr E4W57_RS03945 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen E4W57_RS03965 ENOG4105CS2 ec 3.2.1.21 E4W57_RS03970 ENOG4108Q3X Transcriptional regulator E4W57_RS03975 ENOG4105N5Z UPF0267 protein E4W57_RS03980 ENOG4108UT2 hemolysin iii E4W57_RS03990 ENOG4105Y75 tpr repeat protein E4W57_RS03995 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB E4W57_RS04000 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) E4W57_RS04005 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) E4W57_RS04010 ENOG4105T95 Thiol disulfide interChange protein E4W57_RS04015 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) E4W57_RS04025 ENOG4105CRK lysyL-tRNA synthetase E4W57_RS04030 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) E4W57_RS04035 ENOG4108K5P (LipO)protein E4W57_RS04045 ENOG4105C0R drug resistance transporter emrb qaca subfamily E4W57_RS04060 ENOG4105CPC Aldo Keto reductase E4W57_RS04075 ENOG4105W7K Transcriptional regulator E4W57_RS04105 ENOG4105K89 arsenate reductase E4W57_RS04110 ENOG4105DUX Transporter E4W57_RS04115 ENOG4105V2F Uncharacterized protein yoac E4W57_RS04120 ENOG4105ETP RND efflux system, outer membrane lipoprotein E4W57_RS04125 ENOG4108MI0 Resistance protein E4W57_RS04130 ENOG4105J12 Multidrug resistance protein mdtN E4W57_RS04140 ENOG4105VR1 Pfam:DUF1271 E4W57_RS04145 ENOG410830R acetyltransferase E4W57_RS04155 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin E4W57_RS04160 ENOG4108T65 Fimbrial E4W57_RS04165 ENOG4108SQA Fimbrial E4W57_RS04170 ENOG4105CW0 outer membrane usher protein E4W57_RS04175 ENOG4108NAE Fimbrial chaperone protein E4W57_RS04180 ENOG4108S54 Fimbrial protein E4W57_RS04185 ENOG4108RQP Major type 1 subunit fimbrin E4W57_RS04190 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off E4W57_RS04195 ENOG4108W9T type 1 fimbriae regulatory protein E4W57_RS04200 ENOG4105D7X high-affinity nickel-transporter E4W57_RS04205 ENOG4108ZT1 Transcriptional regulator E4W57_RS04210 ENOG4108KTG Membrane protein, drug metabolite transporter E4W57_RS04220 ENOG4108T1W Fimbrial subunit type 3 E4W57_RS04260 ENOG4107S5I aldo keto reductase E4W57_RS04265 ENOG4108MHD transport protein E4W57_RS04275 ENOG4105C5Q Transcriptional regulator E4W57_RS04280 ENOG4105CHU acetyl-coa acetyltransferase E4W57_RS04285 ENOG4108QGT oligogalacturonate-specific porin E4W57_RS04290 ENOG4105CAZ oligogalacturonide lyase E4W57_RS04295 ENOG4105CHR reductase E4W57_RS04300 ENOG4107QNK )-transporter E4W57_RS04305 ENOG4106NDP Transcriptional regulator E4W57_RS04315 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) E4W57_RS04320 ENOG4108HKT sucrose-6-phosphate hydrolase E4W57_RS04335 ENOG4108IJ9 (ABC) transporter E4W57_RS04340 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component E4W57_RS04345 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component E4W57_RS04350 ENOG4105YKW E4W57_RS04360 ENOG4105RQF LysR family Transcriptional regulator E4W57_RS04370 ENOG4105DDV Transcriptional regulator (LacI family E4W57_RS04375 ENOG4105CK1 PTS System E4W57_RS04380 ENOG4105CS2 ec 3.2.1.21 E4W57_RS04385 ENOG4107YCY Transcriptional regulator E4W57_RS04395 ENOG41060NJ transcriptional regulator E4W57_RS04400 ENOG4105CEY Amp-dependent synthetase and ligase E4W57_RS04405 ENOG4107S74 Lysophospholipid transporter LplT E4W57_RS04410 ENOG4105CPC Aldo Keto reductase E4W57_RS04415 ENOG4105SUV lipoprotein YgdR E4W57_RS04420 ENOG4105EE5 Membrane protein terC E4W57_RS04425 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) E4W57_RS04435 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) E4W57_RS04440 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase E4W57_RS04445 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) E4W57_RS04450 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) E4W57_RS04455 ENOG4105IPU prepilin peptidase dependent protein A E4W57_RS04460 ENOG4105JCS prepilin peptidase dependent protein E4W57_RS04465 ENOG4105SEN Protein of unknown function (DUF2509) E4W57_RS04470 ENOG4105RVB Prepilin peptidase dependent protein c E4W57_RS04475 ENOG4105DSY exodeoxyribonuclease V, gamma E4W57_RS04480 ENOG4107QXK peptidase E4W57_RS04485 ENOG4107QKA exodeoxyribonuclease V beta E4W57_RS04490 ENOG4107QYX exodeoxyribonuclease v alpha E4W57_RS04500 ENOG4107QZM n-acetylglutamate synthase E4W57_RS04505 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase E4W57_RS04510 ENOG4107QZB decarboxylase E4W57_RS04515 ENOG4105JZC GHMP kinase E4W57_RS04520 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) E4W57_RS04525 ENOG4105KTW ethanolamine utilization protein E4W57_RS04530 ENOG4105M3W utilization protein E4W57_RS04540 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) E4W57_RS04545 ENOG4105C0A alcohol dehydrogenase E4W57_RS04550 ENOG4108EKI Dehydrogenase E4W57_RS04560 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml E4W57_RS04575 ENOG4105KNY Microcompartments protein E4W57_RS04580 ENOG4105KNY Microcompartments protein E4W57_RS04590 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit E4W57_RS04595 ENOG4108ZFT Dehydratase small subunit E4W57_RS04600 ENOG4105YCI dehydratase medium subunit E4W57_RS04605 ENOG4105DMB glycerol dehydratase E4W57_RS04610 ENOG4105EHR propanediol utilization protein pduB E4W57_RS04615 ENOG4105KNY Microcompartments protein E4W57_RS04620 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) E4W57_RS04625 ENOG4107XVH Transcriptional regulator E4W57_RS04630 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) E4W57_RS04635 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) E4W57_RS04640 ENOG41081F0 Precorrin-8x methylmutase E4W57_RS04645 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) E4W57_RS04650 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase E4W57_RS04655 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase E4W57_RS04660 ENOG4105CIA precorrin-4 C(11)-methyltransferase E4W57_RS04665 ENOG4108P62 biosynthesis protein (CbiG) E4W57_RS04670 ENOG4105E4R Precorrin-3B C17-methyltransferase E4W57_RS04675 ENOG4105QUC reductase E4W57_RS04680 ENOG4107PPM cobalt chelatase E4W57_RS04685 ENOG4105DVK Precorrin-2 c20-methyltransferase E4W57_RS04690 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) E4W57_RS04695 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) E4W57_RS04700 ENOG4108V4M Cobalt abc transporter E4W57_RS04710 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) E4W57_RS04715 ENOG4108YZT Adenosylcobinamide kinase E4W57_RS04735 ENOG4105CA3 membrane-bound lytic murein transglycosylase E4W57_RS04740 ENOG4105CUZ uba thif-type nad fad binding protein E4W57_RS04745 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) E4W57_RS04750 ENOG4105C9B Cysteine desulfurase E4W57_RS04755 ENOG4105M5B (LipO)protein E4W57_RS04760 ENOG4105ETT transcriptional Regulator, LysR family E4W57_RS04765 ENOG4105M08 Membrane E4W57_RS04775 ENOG4107EDW L-fucose operon activator E4W57_RS04780 ENOG4105NWF RbsD or FucU transport E4W57_RS04785 ENOG4105CMG Carbohydrate kinase E4W57_RS04790 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) E4W57_RS04795 ENOG4105EDR glucose galactose transporter E4W57_RS04800 ENOG4107W7X Aldolase E4W57_RS04805 ENOG4105C0A alcohol dehydrogenase E4W57_RS04810 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease E4W57_RS04815 ENOG4108JU7 Transcriptional regulator E4W57_RS04825 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) E4W57_RS04840 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) E4W57_RS04845 ENOG4108UMI ABC transporter, permease E4W57_RS04850 ENOG4105D01 (LipO)protein E4W57_RS04855 ENOG41079KZ Major Facilitator Superfamily E4W57_RS04865 ENOG4105GVF (ABC) transporter E4W57_RS04870 ENOG4105EJQ L-serine dehydratase E4W57_RS04875 ENOG4105C44 Serine transporter E4W57_RS04880 ENOG4105EWT decarboxylase family E4W57_RS04885 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) E4W57_RS04890 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) E4W57_RS04895 ENOG4105WP7 tRNA pseudouridine synthase C E4W57_RS04900 ENOG4105DR9 pseudouridine synthase E4W57_RS04905 ENOG4105QDK Flavodoxin E4W57_RS04910 ENOG4105DJB Major Facilitator Superfamily E4W57_RS04915 ENOG4105EQX glucarate dehydratase E4W57_RS04920 ENOG4105EQX glucarate dehydratase E4W57_RS04925 ENOG4105BZW Glycerate kinase E4W57_RS04930 ENOG4105BZU Histidine kinase E4W57_RS04935 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) E4W57_RS04940 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) E4W57_RS04945 ENOG4105DXN mazG family E4W57_RS04950 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) E4W57_RS04955 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) E4W57_RS04965 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) E4W57_RS04970 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase E4W57_RS04975 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) E4W57_RS04980 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) E4W57_RS04985 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) E4W57_RS04990 ENOG4108MXK alkaline phosphatase isozyme conversion E4W57_RS04995 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) E4W57_RS05000 ENOG4105C11 sulfate adenylyltransferase), subunit 2 E4W57_RS05010 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) E4W57_RS05015 ENOG4105N0Z inner membrane protein ygbE E4W57_RS05020 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) E4W57_RS05025 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) E4W57_RS05030 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) E4W57_RS05035 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) E4W57_RS05045 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) E4W57_RS05050 ENOG4108K5P (LipO)protein E4W57_RS05055 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E4W57_RS05080 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase E4W57_RS05085 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) E4W57_RS05090 ENOG4105KZM cytoplasmic protein E4W57_RS05100 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) E4W57_RS05120 ENOG4105C4R Atp-dependent dna helicase E4W57_RS05190 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) E4W57_RS05195 ENOG4105EHG Permease protein E4W57_RS05200 ENOG4107R4I Periplasmic binding protein E4W57_RS05205 ENOG4106QJH hemin transport protein E4W57_RS05225 ENOG4108N2Y auxin Efflux E4W57_RS05235 ENOG4105VXR cytoplasmic protein E4W57_RS05240 ENOG4105CC5 ABC transporter E4W57_RS05245 ENOG4105CC5 ABC transporter E4W57_RS05250 ENOG4105DIK (ABC) transporter E4W57_RS05260 ENOG4105DDV Transcriptional regulator (LacI family E4W57_RS05265 ENOG4105DKQ ROK family E4W57_RS05270 ENOG4105VCP PTS System E4W57_RS05280 ENOG4105VZJ PTS System E4W57_RS05285 ENOG4105CK1 PTS System E4W57_RS05290 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) E4W57_RS05300 ENOG4105CS2 ec 3.2.1.21 E4W57_RS05310 ENOG4105C45 hydrogenase expression formation protein (HypE) E4W57_RS05315 ENOG4105CQS hydrogenase expression formation protein HypD E4W57_RS05320 ENOG41083WG hydrogenase assembly chaperone E4W57_RS05325 ENOG4107RSS Hydrogenase accessory protein HypB E4W57_RS05330 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) E4W57_RS05335 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA E4W57_RS05340 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) E4W57_RS05345 ENOG4107R30 NADH dehydrogenase E4W57_RS05350 ENOG4107TDF Formate hydrogenlyase subunit 4 E4W57_RS05355 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) E4W57_RS05360 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit E4W57_RS05365 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit E4W57_RS05370 ENOG4105I6X formate hydrogenlyase maturation E4W57_RS05375 ENOG4108MG9 hydrogenase 3 maturation protease E4W57_RS05385 ENOG4105CS2 ec 3.2.1.21 E4W57_RS05390 ENOG4105C5Y PTS System E4W57_RS05395 ENOG4105DDV Transcriptional regulator (LacI family E4W57_RS05400 ENOG4108RC0 Electron transport protein E4W57_RS05405 ENOG4105C8H hydrogenase maturation protein Hypf E4W57_RS05415 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase E4W57_RS05420 ENOG4105CNW domain protein E4W57_RS05425 ENOG4108JUA Transcriptional regulator E4W57_RS05435 ENOG410804X Transcriptional regulator E4W57_RS05440 ENOG4105J92 DNA-binding transcriptional activator GutM E4W57_RS05445 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase E4W57_RS05450 ENOG4105VI0 Pts system, glucitol sorbitol-specific E4W57_RS05455 ENOG4105DZY Pts system, glucitol sorbitol-specific E4W57_RS05460 ENOG410787A Pts system, glucitol sorbitol-specific E4W57_RS05465 ENOG4105CVE Lytic murein transglycosylase E4W57_RS05480 ENOG4105CC5 ABC transporter E4W57_RS05490 ENOG4107TH8 cina domain protein E4W57_RS05495 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) E4W57_RS05500 ENOG4105Y3E Modulates RecA activity (By similarity) E4W57_RS05505 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) E4W57_RS05510 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) E4W57_RS05540 ENOG4105K3G Periplasmic Protein E4W57_RS05545 ENOG4107VXZ Hydrolase E4W57_RS05550 ENOG4105W39 Membrane E4W57_RS05555 ENOG4105D9M gamma-glutamylcysteine synthetase E4W57_RS05570 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) E4W57_RS05575 ENOG4105C0R drug resistance transporter emrb qaca subfamily E4W57_RS05580 ENOG4105CW7 secretion protein, HlyD family E4W57_RS05585 ENOG4105NTK Transcriptional repressor Mpra E4W57_RS05590 ENOG4105ZED uncharacterized protein ygaH E4W57_RS05595 ENOG4108UMN azlc family E4W57_RS05600 ENOG4105GIJ Glycine betaine E4W57_RS05605 ENOG4108HQS Glycine betaine E4W57_RS05610 ENOG4108IJ7 Glycine betaine E4W57_RS05615 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E4W57_RS05620 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E4W57_RS05625 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) E4W57_RS05630 ENOG4105WAZ (Glutaredoxin-like protein) NrdH E4W57_RS05635 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) E4W57_RS05640 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family E4W57_RS05645 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) E4W57_RS05650 ENOG4108WMJ Protein of unknown function (DUF2002) E4W57_RS05655 ENOG4108RNS Exports L-alanine (By similarity) E4W57_RS05660 ENOG4108X73 DNA- binding protein E4W57_RS05675 ENOG4108V62 Rhodanese domain protein E4W57_RS05680 ENOG41080HT Transcriptional regulator, arsr family E4W57_RS05690 ENOG4108Q2M Transcriptional regulator E4W57_RS05695 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family E4W57_RS05700 ENOG4105C26 Dehydrogenase E4W57_RS05705 ENOG4105X0I Fimbrial E4W57_RS05710 ENOG4108VCD Chaperone E4W57_RS05715 ENOG4105CW0 outer membrane usher protein E4W57_RS05730 ENOG4105CW0 outer membrane usher protein E4W57_RS05735 ENOG4106P2F Pfam:Pili_assembly_C E4W57_RS05740 ENOG4106EAR Fimbrial protein E4W57_RS05745 ENOG4108WQH regulatoR E4W57_RS05760 ENOG4105EWI Short-chain dehydrogenase reductase Sdr E4W57_RS05765 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase E4W57_RS05770 ENOG4105MP9 class II Aldolase E4W57_RS05780 ENOG4106TNF Periplasmic binding protein E4W57_RS05795 ENOG4105CYW agmatinase E4W57_RS05800 ENOG4105EVZ LysR family transcriptional regulator E4W57_RS05815 ENOG4105C1P efflux transporter, rnd family, mfp subunit E4W57_RS05820 ENOG4105UEI Transcriptional Regulator AraC Family E4W57_RS05845 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) E4W57_RS05850 ENOG4108Z1B Cyclase dehydrase E4W57_RS05860 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) E4W57_RS05865 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) E4W57_RS05870 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) E4W57_RS05875 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ E4W57_RS05880 ENOG4108JU6 CBS domain protein E4W57_RS05885 ENOG4106KVJ cytochrome C assembly protein E4W57_RS05890 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY E4W57_RS05895 ENOG4105K5M 30s ribosomal protein S16 E4W57_RS05900 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) E4W57_RS05905 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) E4W57_RS05910 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) E4W57_RS05925 ENOG41090EK ompa motb domain protein E4W57_RS05930 ENOG4108KHX Diguanylate cyclase E4W57_RS05935 ENOG4108WS1 E4W57_RS05940 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) E4W57_RS05945 ENOG4105EHE chorismate mutase- prephenate dehydrogenase E4W57_RS05955 ENOG4105CQC Prephenate dehydratase E4W57_RS05965 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA E4W57_RS05970 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane E4W57_RS05975 ENOG4105C34 Pseudouridine synthase E4W57_RS05980 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase E4W57_RS05985 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit E4W57_RS06010 ENOG4105CSH Transporter E4W57_RS06015 ENOG4105T42 (LipO)protein E4W57_RS06020 ENOG4105JIM Phosphatidylserine synthase E4W57_RS06025 ENOG4105CD5 CoA-binding domain protein E4W57_RS06030 ENOG4106IUH DTW domain containing protein E4W57_RS06035 ENOG4105K63 Thioredoxin E4W57_RS06040 ENOG4105EIB trna rrna methyltransferase E4W57_RS06045 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) E4W57_RS06050 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) E4W57_RS06055 ENOG4105C1J atp-dependent rna helicase E4W57_RS06060 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) E4W57_RS06065 ENOG4108IYU L-aspartate oxidase E4W57_RS06080 ENOG41069PW sigma-e factor negative regulatory protein E4W57_RS06085 ENOG4105VQK sigma E regulatory protein, MucB RseB E4W57_RS06090 ENOG4105WMJ Positive regulator of sigma E, RseC MucC E4W57_RS06095 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) E4W57_RS06100 ENOG4105C3F Signal peptidase i E4W57_RS06105 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) E4W57_RS06110 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) E4W57_RS06115 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) E4W57_RS06120 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) E4W57_RS06125 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) E4W57_RS06130 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding E4W57_RS06135 ENOG4106G6Q Transcriptional regulator E4W57_RS06140 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB E4W57_RS06145 ENOG4108Z6B deaminase E4W57_RS06150 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) E4W57_RS06155 ENOG4108ETH Formylglycinamide ribotide synthetase E4W57_RS06160 ENOG4107WP9 Histidine kinase E4W57_RS06165 ENOG4108SKK alpha helix protein E4W57_RS06170 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family E4W57_RS06175 ENOG4108YZA Nitrogen regulatory protein pii E4W57_RS06180 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) E4W57_RS06185 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) E4W57_RS06190 ENOG4108SB3 DoxX Family E4W57_RS06195 ENOG4108NZE NAGC-like transcriptional regulator E4W57_RS06200 ENOG4107HQ7 repeat protein E4W57_RS06205 ENOG4107QNK )-transporter E4W57_RS06210 ENOG4108ZKT aldose 1-epimerase E4W57_RS06215 ENOG4105D8G Major Facilitator superfamily E4W57_RS06220 ENOG4108MN2 Stationary phase inducible protein CsiE E4W57_RS06230 ENOG4105D7X high-affinity nickel-transporter E4W57_RS06240 ENOG4105ECY inositol monophosphatase E4W57_RS06245 ENOG4105CVS RNA methyltransferase TrmH family, group 1 E4W57_RS06250 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family E4W57_RS06255 ENOG4105C3J Cysteine desulfurase E4W57_RS06260 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins E4W57_RS06265 ENOG4108Z4V iron-sulfur cluster assembly E4W57_RS06270 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) E4W57_RS06275 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB E4W57_RS06280 ENOG4108ZIT Ferredoxin, 2FE-2S E4W57_RS06285 ENOG4105WVQ Fe-S assembly protein IscX E4W57_RS06290 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) E4W57_RS06295 ENOG4105YYA enhanced serine sensitivity protein SseB E4W57_RS06305 ENOG4105KHC sulfurtransferase E4W57_RS06310 ENOG4105DN3 alpha-2-macroglobulin domain protein E4W57_RS06315 ENOG4108JQB penicillin-binding protein 1C E4W57_RS06320 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) E4W57_RS06325 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs E4W57_RS06330 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) E4W57_RS06335 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) E4W57_RS06345 ENOG4105N21 Membrane E4W57_RS06350 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) E4W57_RS06355 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) E4W57_RS06375 ENOG4105VPD cellular component movement E4W57_RS06380 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) E4W57_RS06385 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) E4W57_RS06390 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) E4W57_RS06400 ENOG4105C4X radical SAM domain protein E4W57_RS06415 ENOG41062G3 Protein of unknown function (DUF2633) E4W57_RS06420 ENOG4105BZU Histidine kinase E4W57_RS06425 ENOG4105C9X ppx gppa phosphatase E4W57_RS06430 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) E4W57_RS06435 ENOG4108V3E phosphoribosylglycinamide formyltransferase E4W57_RS06440 ENOG4105CXB phosphoribosylaminoimidazole synthetase E4W57_RS06445 ENOG41066F8 ROK family E4W57_RS06450 ENOG4105CS2 ec 3.2.1.21 E4W57_RS06455 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) E4W57_RS06460 ENOG4105C2W permease E4W57_RS06465 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) E4W57_RS06475 ENOG4105K89 arsenate reductase E4W57_RS06480 ENOG4105ERG peptidase m48, ste24p E4W57_RS06490 ENOG4105C02 permease E4W57_RS06495 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen E4W57_RS06500 ENOG4105RH4 Glycine cleavage system transcriptional repressor E4W57_RS06505 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) E4W57_RS06510 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) E4W57_RS06515 ENOG4105C8V SAICAR synthetase E4W57_RS06520 ENOG4105CGZ zinc metallopeptidase E4W57_RS06525 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) E4W57_RS06530 ENOG4106KED esterase YpfH E4W57_RS06535 ENOG4105XYK UPF0370 protein E4W57_RS06540 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) E4W57_RS06545 ENOG4105KUZ arsenate reductase E4W57_RS06555 ENOG4105BZS acriflavin resistance protein E4W57_RS06560 ENOG4105BZ8 glutamate synthase E4W57_RS06565 ENOG4107VIJ nudix hydrolase E4W57_RS06570 ENOG4108PVD exported protein E4W57_RS06575 ENOG4105CV1 Transketolase (EC 2.2.1.1) E4W57_RS06580 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) E4W57_RS06585 ENOG4105C6K Malic enzyme E4W57_RS06590 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place E4W57_RS06595 ENOG4106S4J ethanolamine utilization protein EutP E4W57_RS06600 ENOG4105NDK ethanolamine utilization protein E4W57_RS06605 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase E4W57_RS06610 ENOG4108IJ2 phosphate acetyltransferase E4W57_RS06615 ENOG4105KNY Microcompartments protein E4W57_RS06620 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml E4W57_RS06625 ENOG4108EKI Dehydrogenase E4W57_RS06630 ENOG4107YMV ethanolamine utilization protein E4W57_RS06635 ENOG4105C0A alcohol dehydrogenase E4W57_RS06640 ENOG4105ENY Ethanolamine utilization protein eutH E4W57_RS06645 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase E4W57_RS06650 ENOG4105CPD ethanolamine ammonia-lyase E4W57_RS06660 ENOG4106D67 ethanolamine utilization protein E4W57_RS06665 ENOG4108X49 Ethanolamine utilization protein EutK E4W57_RS06670 ENOG4108K3Z AraC family transcriptional regulator E4W57_RS06675 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) E4W57_RS06680 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase E4W57_RS06685 ENOG4108R6G acetyltransferase E4W57_RS06690 ENOG4105QZU Inner membrane protein YfeZ E4W57_RS06695 ENOG4105E7K (LipO)protein E4W57_RS06700 ENOG4105EZR dyp-type peroxidase family protein E4W57_RS06710 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein E4W57_RS06715 ENOG4108I5D sulfate abc transporter E4W57_RS06720 ENOG4105ECW sulfate abc transporter E4W57_RS06725 ENOG4108IJ6 ABC transporter E4W57_RS06730 ENOG4105C6T cysteine synthase E4W57_RS06735 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein E4W57_RS06740 ENOG4105CSW GntR family transcriptional regulator E4W57_RS06745 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) E4W57_RS06755 ENOG4105C5Y PTS System E4W57_RS06760 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) E4W57_RS06765 ENOG4105KZ7 phosphocarrier protein hpr E4W57_RS06770 ENOG4105C6T cysteine synthase E4W57_RS06775 ENOG4105EXN Sulfate transport protein CysZ E4W57_RS06780 ENOG4108C6U receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) E4W57_RS06785 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) E4W57_RS06790 ENOG4105VRT cytoplasmic protein E4W57_RS06795 ENOG4105DHU Bile acid E4W57_RS06800 ENOG4108M0I Transcriptional regulator E4W57_RS06820 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) E4W57_RS06825 ENOG4105GXM Putative transcription regulator (DUF1323) E4W57_RS06830 ENOG4105HZG regulatoR E4W57_RS06850 ENOG4105D9N nucleoside E4W57_RS06855 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) E4W57_RS06860 ENOG4109076 Conserved Protein E4W57_RS06865 ENOG4105CPC Aldo Keto reductase E4W57_RS06870 ENOG4107RA9 decarboxylase E4W57_RS06880 ENOG4105CHC glucokinase (EC 2.7.1.2) E4W57_RS06885 ENOG4105DY9 regulatoR E4W57_RS06890 ENOG4108HRK Histidine kinase E4W57_RS06905 ENOG4105CHM Aminotransferase E4W57_RS06915 ENOG4105DJ2 Major Facilitator Superfamily E4W57_RS06920 ENOG4107Y2X deaminase E4W57_RS06925 ENOG4105DND Transcriptional regulator E4W57_RS06945 ENOG4105S64 Formate nitrite transporter E4W57_RS06950 ENOG410903C (LipO)protein E4W57_RS06955 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation E4W57_RS06960 ENOG4105KZW UPF0381 protein E4W57_RS06965 ENOG4105CHU acetyl-coa acetyltransferase E4W57_RS06970 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase E4W57_RS06975 ENOG4108BY2 phosphohistidine phosphatase E4W57_RS06980 ENOG4108DG9 Smr protein MutS2 E4W57_RS06985 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) E4W57_RS06990 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase E4W57_RS06995 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) E4W57_RS07000 ENOG4105EJ9 Membrane E4W57_RS07005 ENOG4108BPE -transporting atpase E4W57_RS07010 ENOG4105MH2 YfcL protein E4W57_RS07015 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) E4W57_RS07020 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) E4W57_RS07025 ENOG4105F9N Major Facilitator Superfamily E4W57_RS07030 ENOG4106WZ1 flagella biosynthesis regulator E4W57_RS07040 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) E4W57_RS07045 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) E4W57_RS07050 ENOG4105DQR SNARE associated Golgi E4W57_RS07055 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) E4W57_RS07060 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase E4W57_RS07065 ENOG4108S3P Sporulation domain protein E4W57_RS07070 ENOG4105E96 Colicin v production protein E4W57_RS07075 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase E4W57_RS07080 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase E4W57_RS07090 ENOG4105E89 ABC transporter E4W57_RS07095 ENOG4105E89 ABC transporter E4W57_RS07100 ENOG4105DSP amino acid AbC transporter E4W57_RS07105 ENOG4106YG3 ABC transporter E4W57_RS07110 ENOG4108JEH abc transporter atp-binding protein E4W57_RS07115 ENOG4105KNA -acetyltransferase E4W57_RS07125 ENOG4105ECP epimerase E4W57_RS07130 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase E4W57_RS07135 ENOG4105CYM Glutathione S-transferase E4W57_RS07140 ENOG4108SHQ Glutathione S-transferase E4W57_RS07145 ENOG4108RE9 Phosphodiesterase E4W57_RS07150 ENOG4105PTV Nudix Hydrolase E4W57_RS07155 ENOG4105C6K Malic enzyme E4W57_RS07160 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) E4W57_RS07165 ENOG4105PQ6 UPF0208 membrane protein E4W57_RS07175 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 E4W57_RS07180 ENOG4107QWE )-transporter E4W57_RS07185 ENOG4105DK2 UPF0207 protein E4W57_RS07190 ENOG4105CHM Aminotransferase E4W57_RS07195 ENOG4107NQ8 LysR family Transcriptional regulator E4W57_RS07200 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain E4W57_RS07205 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) E4W57_RS07210 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) E4W57_RS07215 ENOG4105GKE subunit e E4W57_RS07220 ENOG4107QIZ NADH dehydrogenase E4W57_RS07225 ENOG4108IEH NADH dehydrogenase subunit g E4W57_RS07230 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) E4W57_RS07240 ENOG4107UFS subunit j E4W57_RS07245 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) E4W57_RS07250 ENOG4105D65 subunit l E4W57_RS07255 ENOG4105C8S subunit m E4W57_RS07260 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) E4W57_RS07265 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) E4W57_RS07270 ENOG4107YB6 acetyltransferase, (GNAT) family E4W57_RS07275 ENOG4105E4F Isochorismate synthase E4W57_RS07280 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) E4W57_RS07285 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) E4W57_RS07290 ENOG4108IPT Naphthoate synthase E4W57_RS07295 ENOG4105DNI Converts SHCHC to OSB (By similarity) E4W57_RS07300 ENOG4105CEY Amp-dependent synthetase and ligase E4W57_RS07315 ENOG4108UII YfaZ family E4W57_RS07320 ENOG4108EWA cinA-like protein E4W57_RS07325 ENOG4107258 Transcriptional regulator E4W57_RS07330 ENOG4105CXK mandelate racemase muconate lactonizing E4W57_RS07335 ENOG4105CSP Major Facilitator Superfamily E4W57_RS07340 ENOG4105CNV Aldolase E4W57_RS07345 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) E4W57_RS07350 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B E4W57_RS07355 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A E4W57_RS07360 ENOG4105CXY transporter E4W57_RS07365 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase E4W57_RS07370 ENOG4105XPH Ferredoxin E4W57_RS07375 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E4W57_RS07380 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E4W57_RS07385 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) E4W57_RS07390 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E4W57_RS07395 ENOG4105BZU Histidine kinase E4W57_RS07400 ENOG41068CG regulatoR E4W57_RS07405 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC E4W57_RS07420 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) E4W57_RS07425 ENOG4105CF1 Alkylated DNA repair protein E4W57_RS07430 ENOG4105IBP Cyclic peptide transporter E4W57_RS07435 ENOG4105CJW magnesium transporter E4W57_RS07440 ENOG4105CHH sulfate transporter E4W57_RS07455 ENOG4105F4G Membrane E4W57_RS07465 ENOG4105E68 Sulfatase E4W57_RS07470 ENOG4105PAN UPF0352 protein E4W57_RS07475 ENOG4106V8H Nucleoid-associated protein E4W57_RS07480 ENOG4105N2W Transcriptional regulator E4W57_RS07485 ENOG4107VIJ nudix hydrolase E4W57_RS07500 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) E4W57_RS07505 ENOG4105CFI type iii restriction protein res subunit E4W57_RS07510 ENOG4105I08 Pseudouridine synthase E4W57_RS07515 ENOG4105C2C drug resistance transporter, Bcr CflA E4W57_RS07520 ENOG4105HG6 E4W57_RS07525 ENOG4108JQ5 ABC transporter E4W57_RS07530 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component E4W57_RS07535 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component E4W57_RS07540 ENOG4105E43 Extracellular solute-binding protein, family 5 E4W57_RS07545 ENOG4105CXC rtn protein E4W57_RS07550 ENOG4107TT5 NLP P60 protein E4W57_RS07555 ENOG41076MN Phosphoesterase, PA-phosphatase related E4W57_RS07560 ENOG4105CKI cobalamin synthesis protein E4W57_RS07565 ENOG4105DEI Mannitol dehydrogenase E4W57_RS07570 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) E4W57_RS07580 ENOG4105KRS Proteinase inhibitor E4W57_RS07585 ENOG4105S8Q sugar efflux transporter E4W57_RS07590 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein E4W57_RS07595 ENOG4105DE4 1-phosphofructokinase E4W57_RS07600 ENOG4105DM4 PTS System E4W57_RS07605 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) E4W57_RS07610 ENOG4105HMI Membrane E4W57_RS07615 ENOG4105DUM transcriptional regulator, lysR family E4W57_RS07620 ENOG4108IQI permease E4W57_RS07625 ENOG4105D05 Receptor E4W57_RS07635 ENOG4105EUJ GTP cyclohydrolase i E4W57_RS07640 ENOG4105DHF Membrane E4W57_RS07645 ENOG41060NJ transcriptional regulator E4W57_RS07655 ENOG4105C2J ABC transporter E4W57_RS07660 ENOG4107SDZ Galactoside transport system permease protein mglC E4W57_RS07665 ENOG4107GZ4 SanA protein E4W57_RS07670 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) E4W57_RS07675 ENOG41067MG lrgb family E4W57_RS07680 ENOG4105VAW lrga family E4W57_RS07685 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) E4W57_RS07690 ENOG4105TW1 Carbohydrate-selective porin OprB E4W57_RS07705 ENOG4105CS2 ec 3.2.1.21 E4W57_RS07715 ENOG4105KHU inner membrane protein YohD E4W57_RS07720 ENOG41069YE inner membrane protein yohC E4W57_RS07725 ENOG41061WM D-Alanyl-D-Alanine E4W57_RS07735 ENOG4105CXG d-lactate dehydrogenase E4W57_RS07740 ENOG4107QK4 glycoside hydrolase, family 3 domain protein E4W57_RS07745 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system E4W57_RS07750 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component E4W57_RS07755 ENOG4108IJ8 ABC transporter E4W57_RS07760 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component E4W57_RS07770 ENOG4108HRK Histidine kinase E4W57_RS07775 ENOG4108NEV two component transcriptional regulator, LytTR family E4W57_RS07780 ENOG4108W15 Protein of unknown function (DUF1456) E4W57_RS07785 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) E4W57_RS07790 ENOG4105D1F ATP-binding protein E4W57_RS07800 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly E4W57_RS07810 ENOG4105C7N Xanthine uracil vitamin C permease E4W57_RS07815 ENOG4105CPN adenine deaminase E4W57_RS07820 ENOG4105DUM transcriptional regulator, lysR family E4W57_RS07835 ENOG4105DWF phosphomethylpyrimidine kinase E4W57_RS07840 ENOG4105EIE fructose-bisphosphate aldolase E4W57_RS07845 ENOG4105IE8 Alpha-ketoglutarate permease E4W57_RS07870 ENOG4105DEI Mannitol dehydrogenase E4W57_RS07875 ENOG4105CMG Carbohydrate kinase E4W57_RS07880 ENOG4105IE8 Alpha-ketoglutarate permease E4W57_RS07885 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 E4W57_RS07890 ENOG4105CXK mandelate racemase muconate lactonizing E4W57_RS07895 ENOG4105DEF Extracellular solute-binding protein, family 5 E4W57_RS07900 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component E4W57_RS07905 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component E4W57_RS07915 ENOG4108JQ7 (ABC) transporter E4W57_RS07925 ENOG4105CFP Peptidase U32 E4W57_RS07930 ENOG4105E3W Two component transcriptional regulator (Winged helix family E4W57_RS07935 ENOG4105EB3 Histidine kinase E4W57_RS07940 ENOG4105C0R drug resistance transporter emrb qaca subfamily E4W57_RS07945 ENOG4105BZS acriflavin resistance protein E4W57_RS07950 ENOG4105BZS acriflavin resistance protein E4W57_RS07955 ENOG4105ENT Efflux transporter rnd family, mfp subunit E4W57_RS07960 ENOG4105CK2 sodium dicarboxylate symporter E4W57_RS07980 ENOG4105BZU Histidine kinase E4W57_RS07985 ENOG4105R8A Heat shock protein E4W57_RS07990 ENOG4105D03 DNA-3-methyladenine glycosylase II E4W57_RS07995 ENOG4105DBI uridine monophosphokinase E4W57_RS08000 ENOG4105DHP deoxycytidine triphosphate deaminase E4W57_RS08005 ENOG4108GAE asmA family E4W57_RS08010 ENOG4105EE5 Membrane protein terC E4W57_RS08015 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase E4W57_RS08020 ENOG4105MH5 phosphoesterase PA-phosphatase related protein E4W57_RS08030 ENOG4108MRJ E4W57_RS08035 ENOG4105DAY polysaccharide export protein E4W57_RS08090 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) E4W57_RS08100 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) E4W57_RS08155 ENOG4105CPK Glycosyl transferase (Group 1 E4W57_RS08180 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase E4W57_RS08185 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) E4W57_RS08195 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) E4W57_RS08200 ENOG4105ECC imidazole-glycerol-phosphate dehydratase E4W57_RS08205 ENOG4105CIH Imidazole acetol-phosphate transaminase E4W57_RS08215 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) E4W57_RS08225 ENOG4107SRH Nad-dependent epimerase dehydratase E4W57_RS08230 ENOG4105EQ1 Transcriptional regulator E4W57_RS08240 ENOG4105CUB amino acid E4W57_RS08245 ENOG4105YVS arsR family transcriptional regulator E4W57_RS08250 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) E4W57_RS08255 ENOG4105CJB Exodeoxyribonuclease I E4W57_RS08260 ENOG4105DZ1 carboxypeptidase E4W57_RS08270 ENOG4105DR8 Membrane E4W57_RS08275 ENOG41090HJ UPF0265 protein E4W57_RS08280 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) E4W57_RS08285 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) E4W57_RS08290 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) E4W57_RS08300 ENOG41090U3 tautomerase E4W57_RS08305 ENOG4105HEI LysR family (Transcriptional regulator E4W57_RS08310 ENOG4108KMH lipoate-protein ligase a E4W57_RS08315 ENOG4105CSH Transporter E4W57_RS08325 ENOG4105BZU Histidine kinase E4W57_RS08335 ENOG4108YS1 cytoplasmic protein E4W57_RS08340 ENOG4105YP6 Domain of unknown function (DUF1869) E4W57_RS08345 ENOG4105ETT transcriptional Regulator, LysR family E4W57_RS08360 ENOG4105BZU Histidine kinase E4W57_RS08380 ENOG4105UQX Mate efflux family protein E4W57_RS08390 ENOG4105FYV Amp nucleosidase E4W57_RS08410 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family E4W57_RS08415 ENOG4108WUH Transcriptional regulator, TetR family E4W57_RS08420 ENOG4105EEQ Na H antiporter E4W57_RS08435 ENOG4107R11 Transcriptional regulator E4W57_RS08440 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein E4W57_RS08535 ENOG4108PCE TRANSFER protein E4W57_RS08565 ENOG4106D0Q Type IV secretion system protein VirB2 E4W57_RS08610 ENOG4107ZSV Receptor E4W57_RS08615 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase E4W57_RS08635 ENOG4105C0W non-ribosomal peptide synthetase E4W57_RS08650 ENOG4105BZ1 (ABC) transporter E4W57_RS08655 ENOG4105EYM Major Facilitator superfamily E4W57_RS08680 ENOG4105EHG Permease protein E4W57_RS08685 ENOG4105MYN Zinc uptake regulation protein E4W57_RS08695 ENOG4105CKI cobalamin synthesis protein E4W57_RS08705 ENOG4107T5J pyridine nucleotide-disulfide oxidoreductase E4W57_RS08720 ENOG4105CKI cobalamin synthesis protein E4W57_RS08730 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) E4W57_RS08750 ENOG4105CC5 ABC transporter E4W57_RS08755 ENOG4105CC5 ABC transporter E4W57_RS08760 ENOG4105DIK (ABC) transporter E4W57_RS08765 ENOG4105DSE periplasmic solute binding protein E4W57_RS08770 ENOG4105C22 threonyL-tRNA synthetase E4W57_RS08780 ENOG4105CD3 dihydroorotase E4W57_RS08785 ENOG4105D52 delta-aminolevulinic acid dehydratase E4W57_RS08810 ENOG4105DSE periplasmic solute binding protein E4W57_RS08815 ENOG4105CC5 ABC transporter E4W57_RS08820 ENOG4105DIK (ABC) transporter E4W57_RS08840 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) E4W57_RS08850 ENOG4105FCK Membrane E4W57_RS08855 ENOG4105Y0K Inner membrane protein YedR E4W57_RS08860 ENOG4105EST Metal Dependent Phosphohydrolase E4W57_RS08865 ENOG4105DVF Cytosine-specific methyltransferase E4W57_RS08870 ENOG41090BB DNA mismatch endonuclease (vsr) E4W57_RS08875 ENOG4105FDR Membrane E4W57_RS08880 ENOG4105CKW Inner membrane protein yedI E4W57_RS08890 ENOG4105YX3 cellular response to acidity E4W57_RS08905 ENOG4105JCU Inherit from NOG: (Lipo)protein E4W57_RS08910 ENOG4105E5K Alpha-amylase E4W57_RS08915 ENOG4105EAB amino acid AbC transporter E4W57_RS08920 ENOG4105K6H D-cysteine desulfhydrase E4W57_RS08925 ENOG4105E5Q amino acid AbC transporter E4W57_RS08930 ENOG4105CDA abc transporter atp-binding protein E4W57_RS08935 ENOG4105VJY transcriptional regulator E4W57_RS08940 ENOG4105XVG cytoplasmic protein E4W57_RS08945 ENOG4105WH1 Two component transcriptional regulator luxr family E4W57_RS08980 ENOG4106RHG Yeca family E4W57_RS08985 ENOG4105E0U tyrosine-specific transport protein E4W57_RS08990 ENOG4105VVZ metal-binding protein E4W57_RS08995 ENOG41090A1 ferritin E4W57_RS09010 ENOG4105C0R drug resistance transporter emrb qaca subfamily E4W57_RS09015 ENOG4105N4N Protein of unknown function (DUF2766) E4W57_RS09030 ENOG4108UEC Ferritin-like protein E4W57_RS09040 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator E4W57_RS09050 ENOG4105CNN ABC, transporter E4W57_RS09060 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase E4W57_RS09065 ENOG4108VA4 Universal stress protein E4W57_RS09070 ENOG4105CT4 transporter E4W57_RS09075 ENOG4105F5H Glycosyl Hydrolase Family 88 E4W57_RS09080 ENOG4105C75 arginyL-tRNA synthetase E4W57_RS09085 ENOG4106ZCM YecM protein E4W57_RS09090 ENOG4106N3A copper homeostasis protein cutc E4W57_RS09095 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) E4W57_RS09100 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) E4W57_RS09105 ENOG4105WJG Glutathione E4W57_RS09110 ENOG41081XQ Conserved Protein E4W57_RS09115 ENOG4105D3W isochorismatase E4W57_RS09120 ENOG4105C9M aspartyl-trna synthetase E4W57_RS09125 ENOG4108TIT dATP pyrophosphohydrolase E4W57_RS09130 ENOG4105CDY transcriptional regulatory protein E4W57_RS09135 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) E4W57_RS09140 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) E4W57_RS09145 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) E4W57_RS09150 ENOG4105FAV ABC, transporter E4W57_RS09160 ENOG4105NXV High-affinity zinc uptake system protein E4W57_RS09165 ENOG4105DR5 peptidase E4W57_RS09170 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase E4W57_RS09175 ENOG4105CA9 Pyruvate kinase E4W57_RS09180 ENOG4106KNT transcriptional regulator E4W57_RS09190 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase E4W57_RS09195 ENOG4105C01 Dihydroxy-acid dehydratase E4W57_RS09200 ENOG4108UHU Aldolase E4W57_RS09210 ENOG4105X2V dna damage-inducible protein E4W57_RS09215 ENOG4108Q2J Inner membrane protein YebE E4W57_RS09220 ENOG4105CUG Oligopeptidase b E4W57_RS09225 ENOG4105UMD exodeoxyribonuclease X E4W57_RS09230 ENOG4105MPK DNA polymerase III subunit theta E4W57_RS09235 ENOG4105FXM Copper resistance protein E4W57_RS09240 ENOG4108PNC copper resistance E4W57_RS09245 ENOG4105NKT exported protein E4W57_RS09255 ENOG4108MJ5 VirK protein E4W57_RS09260 ENOG4108R1E Serine threonine protein phosphatase 1 E4W57_RS09265 ENOG4105UVW uncharacterized protein yebW E4W57_RS09270 ENOG4105WT8 Protein of unknown function (DUF1480) E4W57_RS09275 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B E4W57_RS09280 ENOG4105DY2 Paraquat-inducible protein b E4W57_RS09285 ENOG4105H2K paraquat-inducible protein a E4W57_RS09290 ENOG4108ZGC gaf domain protein E4W57_RS09295 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) E4W57_RS09300 ENOG4105CN1 protease E4W57_RS09305 ENOG4105D0M Protease HtpX homolog E4W57_RS09310 ENOG4105C0R drug resistance transporter emrb qaca subfamily E4W57_RS09315 ENOG4105J4Q Transcriptional regulator E4W57_RS09320 ENOG4105TIK E4W57_RS09330 ENOG4105Q3Y exported protein E4W57_RS09345 ENOG4105CJN penicillin-binding protein E4W57_RS09350 ENOG4105DHI Methyltransferase E4W57_RS09355 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) E4W57_RS09360 ENOG4108NK4 UPF0266 membrane protein E4W57_RS09365 ENOG4105F3R pts system mannose fructose sorbose family iid E4W57_RS09370 ENOG4105ETZ PTS System E4W57_RS09375 ENOG4105DAS pts system E4W57_RS09380 ENOG4105EE5 Membrane protein terC E4W57_RS09385 ENOG4107XTP (EAL) domain protein E4W57_RS09390 ENOG4105EJQ L-serine dehydratase E4W57_RS09395 ENOG4105P8F nudix hydrolase E4W57_RS09405 ENOG4105X5C UPF0181 protein E4W57_RS09410 ENOG4105M4H endoribonuclease L-psp E4W57_RS09415 ENOG4105DVT helicase E4W57_RS09420 ENOG41072GX Peptidase M22 Glycoprotease E4W57_RS09425 ENOG4105Y4Z Outer Membrane Lipoprotein E4W57_RS09430 ENOG4105CEY Amp-dependent synthetase and ligase E4W57_RS09435 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) E4W57_RS09440 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) E4W57_RS09445 ENOG4107QMS site-determining protein E4W57_RS09450 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) E4W57_RS09455 ENOG4105VNG YcgL domain-containing protein E4W57_RS09460 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase E4W57_RS09465 ENOG4108ZZ3 UPF0260 protein E4W57_RS09475 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) E4W57_RS09480 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) E4W57_RS09485 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) E4W57_RS09490 ENOG4105ED1 spovr family E4W57_RS09500 ENOG4105MWK D-amino acid dehydrogenase, small subunit E4W57_RS09510 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) E4W57_RS09515 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A E4W57_RS09520 ENOG4106JQ5 Transglycosylase SLT domain E4W57_RS09525 ENOG4105E0K tonB-dependent siderophore receptor E4W57_RS09580 ENOG410811B TRANSCRIPTIONal E4W57_RS09585 ENOG4105C7B Threonine dehydratase E4W57_RS09590 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) E4W57_RS09600 ENOG4105C6N Formate acetyltransferase E4W57_RS09615 ENOG4105C32 Amino acid ABC transporter (Permease) E4W57_RS09620 ENOG4105CF8 branched-chain amino acid ABC transporter, permease E4W57_RS09625 ENOG4105C0Z ABC transporter E4W57_RS09630 ENOG4108IV0 ABC, transporter E4W57_RS09635 ENOG4107YNJ LysR family Transcriptional regulator E4W57_RS09655 ENOG4105CSH Transporter E4W57_RS09665 ENOG4105F04 LysR family Transcriptional regulator E4W57_RS09675 ENOG4105D3G Pseudouridine synthase E4W57_RS09680 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme E4W57_RS09700 ENOG4108ZG0 Ompa motb domain protein E4W57_RS09710 ENOG4105CS6 Rhs element vgr protein E4W57_RS09715 ENOG4106678 morphogenetic protein associated with SpoVID E4W57_RS09775 ENOG4105C3G gtp-binding protein E4W57_RS09780 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) E4W57_RS09785 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria E4W57_RS09795 ENOG4105CHH sulfate transporter E4W57_RS09800 ENOG4105C5T Phosphoribosyl pyrophosphate synthase E4W57_RS09805 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) E4W57_RS09815 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) E4W57_RS09820 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) E4W57_RS09825 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) E4W57_RS09830 ENOG4108YY7 Invasion gene expression up-regulator SirB E4W57_RS09835 ENOG41063JG Transcriptional regulator E4W57_RS09840 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase E4W57_RS09845 ENOG4105EWV Sodium calcium exchanger membrane region E4W57_RS09850 ENOG4105WS7 Cation transport regulator E4W57_RS09855 ENOG4108NH8 Cation transport protein E4W57_RS09865 ENOG41090EX DsrE family E4W57_RS09875 ENOG4105I5W Transporter E4W57_RS09885 ENOG4105D7T ABC transporter E4W57_RS09890 ENOG4107QZF nitrite reductase NADPH large subunit E4W57_RS09900 ENOG4105ID0 Putative invasin E4W57_RS09905 ENOG4105WH1 Two component transcriptional regulator luxr family E4W57_RS09910 ENOG4105BZU Histidine kinase E4W57_RS09915 ENOG4105DQQ Major facilitator superfamily MFS_1 E4W57_RS09925 ENOG4105CRU nitrate reductase, alpha subunit E4W57_RS09930 ENOG4108IUE nitrate reductase beta subunit E4W57_RS09935 ENOG4105R3A Nitrate reductase E4W57_RS09940 ENOG41076YT nitrate reductase, gamma subunit E4W57_RS09980 ENOG4105CIY formyltetrahydrofolate deformylase E4W57_RS09995 ENOG4105I93 response regulator E4W57_RS10000 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase E4W57_RS10015 ENOG4107104 thymidine kinase E4W57_RS10020 ENOG4105C0A alcohol dehydrogenase E4W57_RS10030 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein E4W57_RS10035 ENOG4108J59 Extracellular solute-binding protein, family 5 E4W57_RS10040 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component E4W57_RS10045 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component E4W57_RS10050 ENOG4105C3U ABC transporter E4W57_RS10055 ENOG4108JQ7 (ABC) transporter E4W57_RS10060 ENOG4105EYW Ion transport protein E4W57_RS10065 ENOG4108W5H UPF0263 protein E4W57_RS10070 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) E4W57_RS10080 ENOG4108YYC ycei family E4W57_RS10090 ENOG4105K9H YciI-like protein E4W57_RS10095 ENOG410822N TonB family E4W57_RS10105 ENOG4105P10 Uncharacterized protein ydiZ E4W57_RS10110 ENOG4105DE4 1-phosphofructokinase E4W57_RS10115 ENOG4108NE3 Salt-induced outer membrane protein E4W57_RS10130 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) E4W57_RS10135 ENOG41082NX 50s ribosomal protein l35 E4W57_RS10150 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) E4W57_RS10155 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) E4W57_RS10160 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) E4W57_RS10170 ENOG4105MWK D-amino acid dehydrogenase, small subunit E4W57_RS10175 ENOG4105RQF LysR family Transcriptional regulator E4W57_RS10185 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) E4W57_RS10190 ENOG4105D01 (LipO)protein E4W57_RS10195 ENOG4108V06 Glutathione peroxidase E4W57_RS10205 ENOG4108QBX (LipO)protein E4W57_RS10210 ENOG4105CNG UPF0061 protein E4W57_RS10220 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) E4W57_RS10235 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) E4W57_RS10245 ENOG4105IPI Membrane E4W57_RS10250 ENOG4105CQB FAD linked oxidase domain protein E4W57_RS10255 ENOG4105KA0 thioesterase Superfamily protein E4W57_RS10260 ENOG4105Y3U Transglycosylase-associated protein E4W57_RS10275 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) E4W57_RS10285 ENOG4105E0A ABC, transporter E4W57_RS10290 ENOG4105EHG Permease protein E4W57_RS10300 ENOG4106KR7 LysR family Transcriptional regulator E4W57_RS10325 ENOG4105DMF Dehydrogenase E4W57_RS10330 ENOG4105KBX Transcriptional regulator, TetR family E4W57_RS10350 ENOG4108Z4V iron-sulfur cluster assembly E4W57_RS10355 ENOG4105DIW FeS assembly protein SUFB E4W57_RS10360 ENOG4105C3K feS assembly ATPase SufC E4W57_RS10365 ENOG4105JRK feS assembly protein SufD E4W57_RS10370 ENOG4105C9B Cysteine desulfurase E4W57_RS10375 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) E4W57_RS10380 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein E4W57_RS10390 ENOG4105CA9 Pyruvate kinase E4W57_RS10405 ENOG4105RFR Protein of unknown function (DUF2767) E4W57_RS10420 ENOG4105DJB Major Facilitator Superfamily E4W57_RS10425 ENOG4105E2X shikimate dehydrogenase E4W57_RS10430 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein E4W57_RS10435 ENOG4108W0P ABC transporter E4W57_RS10440 ENOG4105EHG Permease protein E4W57_RS10445 ENOG4105S10 periplasmic binding protein E4W57_RS10450 ENOG4108K2P TRANSCRIPTIONal E4W57_RS10455 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase E4W57_RS10460 ENOG4105MI0 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively (By similarity) E4W57_RS10465 ENOG4107UB2 Alpha beta hydrolase fold E4W57_RS10470 ENOG4105IKQ hydratase E4W57_RS10480 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) E4W57_RS10485 ENOG4108SC4 )-transporter E4W57_RS10500 ENOG4108T2C cysteine dioxygenase type I E4W57_RS10505 ENOG4106KR7 LysR family Transcriptional regulator E4W57_RS10510 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) E4W57_RS10530 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component E4W57_RS10535 ENOG4108IY8 ABC, transporter E4W57_RS10545 ENOG4105E0A ABC, transporter E4W57_RS10550 ENOG4105DQ5 transport system permease protein E4W57_RS10570 ENOG4106PMH Extracellular solute-binding protein family 3 E4W57_RS10575 ENOG4105E5Q amino acid AbC transporter E4W57_RS10580 ENOG4105CDA abc transporter atp-binding protein E4W57_RS10595 ENOG41083G8 Multidrug resistance protein MdtM E4W57_RS10620 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) E4W57_RS10625 ENOG4105DG4 malate L-lactate dehydrogenase E4W57_RS10630 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC E4W57_RS10635 ENOG4107Z33 ABC transporter, permease E4W57_RS10665 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) E4W57_RS10670 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) E4W57_RS10675 ENOG41060IM Heme exporter protein E4W57_RS10685 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) E4W57_RS10690 ENOG4105DA4 cytochrome c-type biogenesis protein E4W57_RS10695 ENOG4107QX9 Thiol disulfide interChange protein E4W57_RS10700 ENOG4105KWW Biogenesis protein E4W57_RS10705 ENOG4108M1T Cytochrome c-type biogenesis protein E4W57_RS10720 ENOG41062D9 Histidine kinase E4W57_RS10725 ENOG4105E3W Two component transcriptional regulator (Winged helix family E4W57_RS10740 ENOG4105BZS acriflavin resistance protein E4W57_RS10750 ENOG4105CHR reductase E4W57_RS10755 ENOG4105C7K acetolactate synthase E4W57_RS10770 ENOG4105DTD Dehydrogenase E4W57_RS10775 ENOG4105CY2 Citrate transporter E4W57_RS10780 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) E4W57_RS10785 ENOG4105CHU acetyl-coa acetyltransferase E4W57_RS10790 ENOG4107QNJ CoA-transferase subunit B E4W57_RS10800 ENOG4106NZI LysR family Transcriptional regulator E4W57_RS10820 ENOG4105CQB FAD linked oxidase domain protein E4W57_RS10825 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component E4W57_RS10845 ENOG4105KME endoribonuclease L-psp E4W57_RS10850 ENOG4107TTD cytosine deaminase E4W57_RS10860 ENOG4105EMY transcriptional regulator E4W57_RS10905 ENOG4108JQ7 (ABC) transporter E4W57_RS10910 ENOG4105C3U ABC transporter E4W57_RS10935 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase E4W57_RS10940 ENOG4105E98 transcriptional regulator DeoR family E4W57_RS10950 ENOG4107B2H carbonic anhydrase E4W57_RS10995 ENOG4107FW0 short-chain dehydrogenase reductase E4W57_RS11025 ENOG4108URH decarboxylase E4W57_RS11035 ENOG4107QI1 Mate efflux family protein E4W57_RS11040 ENOG4108R6K riboflavin synthase, subunit alpha E4W57_RS11045 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase E4W57_RS11050 ENOG4105CZQ inner membrane transport protein YdhC E4W57_RS11055 ENOG4105F52 Transcriptional regulator E4W57_RS11060 ENOG4105ETE Transcriptional regulator (LacI family E4W57_RS11070 ENOG4105F27 Major Facilitator E4W57_RS11075 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) E4W57_RS11085 ENOG4105K4H Nlp p60 protein E4W57_RS11090 ENOG4105M2J Glutaredoxin E4W57_RS11095 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) E4W57_RS11100 ENOG4108UYE Lactoylglutathione lyase E4W57_RS11105 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E4W57_RS11110 ENOG4108WUH Transcriptional regulator, TetR family E4W57_RS11115 ENOG4105XZD Fe-S protein E4W57_RS11120 ENOG4107RGM aldo keto reductase E4W57_RS11125 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) E4W57_RS11130 ENOG4105DSW Fusaric acid resistance protein E4W57_RS11135 ENOG4105Y49 secretion protein, HlyD family E4W57_RS11150 ENOG4105BZU Histidine kinase E4W57_RS11155 ENOG4108XTF Outer Membrane Lipoprotein E4W57_RS11160 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) E4W57_RS11165 ENOG410642K Lysozyme inhibitor E4W57_RS11170 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) E4W57_RS11175 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) E4W57_RS11180 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) E4W57_RS11185 ENOG4108K3A Glutathione S-transferase E4W57_RS11195 ENOG4105CSM endonuclease III E4W57_RS11205 ENOG4108UQQ Electron transport complex E4W57_RS11230 ENOG4105M9B inner membrane protein ydgK E4W57_RS11240 ENOG4105CS2 ec 3.2.1.21 E4W57_RS11250 ENOG4105D9R oxidoreductase E4W57_RS11255 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) E4W57_RS11260 ENOG4105EQ0 Major Facilitator superfamily E4W57_RS11280 ENOG4105CPW cytochrome b561 E4W57_RS11300 ENOG4105DDW LysR family Transcriptional regulator E4W57_RS11305 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha E4W57_RS11310 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta E4W57_RS11315 ENOG4105E32 cytoplasmic protein E4W57_RS11320 ENOG4105EBR Carboxylesterase E4W57_RS11335 ENOG4108Z9I -acetyltransferase E4W57_RS11340 ENOG4107WE3 acetyltransferase YdcK E4W57_RS11345 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein E4W57_RS11350 ENOG41088CC tellurite resistance protein tehB E4W57_RS11355 ENOG4108KKZ (LipO)protein E4W57_RS11365 ENOG4105UEI Transcriptional Regulator AraC Family E4W57_RS11370 ENOG4105DKK Benzoate E4W57_RS11375 ENOG4108JCI Transcriptional regulator E4W57_RS11385 ENOG4105CFP Peptidase U32 E4W57_RS11405 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii E4W57_RS11410 ENOG4105C4M (Ubiquinol oxidase) subunit I E4W57_RS11415 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family E4W57_RS11420 ENOG4107TYH extracellular solute-binding protein family 1 E4W57_RS11425 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) E4W57_RS11430 ENOG4105D81 ABC transporter, permease E4W57_RS11435 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component E4W57_RS11440 ENOG4105C26 Dehydrogenase E4W57_RS11465 ENOG410654E Membrane E4W57_RS11470 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 E4W57_RS11480 ENOG4105DEF Extracellular solute-binding protein, family 5 E4W57_RS11485 ENOG4105R71 cytoplasmic protein E4W57_RS11490 ENOG4108T9Y Inner membrane protein ydcZ E4W57_RS11495 ENOG4108Z7F N-acetyltransferase E4W57_RS11505 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein E4W57_RS11510 ENOG4105DU0 nucleoside hydrolase E4W57_RS11520 ENOG41065TG regulatoR E4W57_RS11525 ENOG4105CI2 imidazolone-5-propionate hydrolase E4W57_RS11530 ENOG4105CHB tonB-dependent Receptor E4W57_RS11535 ENOG4108NS2 receptor E4W57_RS11545 ENOG4105C85 amino acid E4W57_RS11550 ENOG4105EQ2 LysR family Transcriptional regulator E4W57_RS11560 ENOG4105DEN Luciferase family E4W57_RS11575 ENOG4105EAB amino acid AbC transporter E4W57_RS11585 ENOG4105DRP amino acid AbC transporter E4W57_RS11590 ENOG4105CDA abc transporter atp-binding protein E4W57_RS11600 ENOG4108N27 Glutathione S-transferase E4W57_RS11610 ENOG4108MEJ flavin reductase domain protein E4W57_RS11615 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) E4W57_RS11620 ENOG4105C4Y ABC transporter E4W57_RS11625 ENOG4107RCV ABC transporter, permease E4W57_RS11630 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase E4W57_RS11635 ENOG4105D0D Nitrate reductase 2, gamma subunit E4W57_RS11640 ENOG4108NZN Respiratory nitrate reductase 2 delta chain E4W57_RS11645 ENOG4108IUE nitrate reductase beta subunit E4W57_RS11650 ENOG4105CRU nitrate reductase, alpha subunit E4W57_RS11655 ENOG4107QND Nitrite extrusion protein E4W57_RS11670 ENOG4107HP6 Transcriptional regulator E4W57_RS11675 ENOG4105DTQ mandelate racemase muconate lactonizing E4W57_RS11680 ENOG4105NN7 muconolactone delta-isomerase E4W57_RS11685 ENOG410626B catechol 1,2-dioxygenase E4W57_RS11695 ENOG4108UKV benzoate 1,2-dioxygenase E4W57_RS11720 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein E4W57_RS11725 ENOG4108MG3 formate dehydrogenase E4W57_RS11740 ENOG4105CSR polyphosphate kinase 2 E4W57_RS11750 ENOG4105F27 Major Facilitator E4W57_RS11765 ENOG4108JQ6 ABC transporter E4W57_RS11770 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component E4W57_RS11785 ENOG4105DQ4 alcohol dehydrogenase E4W57_RS11800 ENOG4105C5H ABC transporter E4W57_RS11815 ENOG4107R1I NAD-dependent malic enzyme E4W57_RS11835 ENOG4105EQ2 LysR family Transcriptional regulator E4W57_RS11840 ENOG4105N0E Protein of unknown function (DUF2543) E4W57_RS11845 ENOG4105CYX Short-chain dehydrogenase reductase Sdr E4W57_RS11860 ENOG4108N8X transition metal ion binding E4W57_RS11870 ENOG4105CG3 alpha amylase, catalytic region E4W57_RS11890 ENOG4108YDI single-species biofilm formation on inanimate substrate E4W57_RS11900 ENOG4108Z9K Osmotically inducible protein E4W57_RS11925 ENOG4105FFC UPF0187 protein E4W57_RS11930 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit E4W57_RS11935 ENOG4105C5Q Transcriptional regulator E4W57_RS11940 ENOG4108KUU Inner membrane metabolite transport protein ydjE E4W57_RS11945 ENOG4105KT7 mgtC SapB transporter E4W57_RS11950 ENOG4105D6Z AFG1 family ATPase E4W57_RS11955 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) E4W57_RS11960 ENOG4106KR7 LysR family Transcriptional regulator E4W57_RS11980 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) E4W57_RS11985 ENOG4107VK2 coenzyme PQQ biosynthesis protein PqqF E4W57_RS11990 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E E4W57_RS12000 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) E4W57_RS12005 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) E4W57_RS12015 ENOG4108IGT Dipeptidase E4W57_RS12020 ENOG4108J2P Alpha beta hydrolase fold E4W57_RS12030 ENOG4105E0F Histidine kinase E4W57_RS12045 ENOG4105DY8 decarboxylase E4W57_RS12050 ENOG4108JPW Aminotransferase E4W57_RS12055 ENOG4107Z6I Thiamine biosynthesis protein E4W57_RS12060 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component E4W57_RS12065 ENOG4108YI8 ABC transporter E4W57_RS12070 ENOG4105ETU transcriptional activator (TenA E4W57_RS12085 ENOG4105CIB oxidoreductase Domain protein E4W57_RS12095 ENOG4105ETE Transcriptional regulator (LacI family E4W57_RS12100 ENOG4105BZU Histidine kinase E4W57_RS12105 ENOG4107QUY Guanine deaminase E4W57_RS12110 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease E4W57_RS12145 ENOG4106H3A restriction E4W57_RS12155 ENOG41089BK Glutamine amido-transferase E4W57_RS12160 ENOG4105R1U AraC Family Transcriptional Regulator E4W57_RS12175 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) E4W57_RS12200 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) E4W57_RS12225 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) E4W57_RS12245 ENOG4105E5Q amino acid AbC transporter E4W57_RS12255 ENOG4105C5R Aminotransferase E4W57_RS12270 ENOG4105CBN LysR family transcriptional regulator E4W57_RS12280 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E4W57_RS12285 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain E4W57_RS12290 ENOG4105CSH Transporter E4W57_RS12335 ENOG4105FCD Major Facilitator E4W57_RS12345 ENOG4105ETE Transcriptional regulator (LacI family E4W57_RS12350 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia E4W57_RS12360 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC E4W57_RS12365 ENOG4105UP7 3-epimerase E4W57_RS12375 ENOG4108YRF PTS System E4W57_RS12380 ENOG4105DM4 PTS System E4W57_RS12385 ENOG410829K Lysine exporter protein (Lyse ygga) E4W57_RS12395 ENOG4105CBN LysR family transcriptional regulator E4W57_RS12400 ENOG4105HEI LysR family (Transcriptional regulator E4W57_RS12415 ENOG4107PP3 Acetylornithine deacetylase E4W57_RS12430 ENOG4105CNN ABC, transporter E4W57_RS12435 ENOG4105C2J ABC transporter E4W57_RS12440 ENOG4105ETE Transcriptional regulator (LacI family E4W57_RS12470 ENOG4109066 lysm domain bon superfamily protein E4W57_RS12475 ENOG4105CXY transporter E4W57_RS12480 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC E4W57_RS12490 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta E4W57_RS12495 ENOG4105RHY Pfam:UPF0157 E4W57_RS12500 ENOG4105EQ2 LysR family Transcriptional regulator E4W57_RS12505 ENOG4105CPC Aldo Keto reductase E4W57_RS12510 ENOG4107SET aldo keto reductase E4W57_RS12515 ENOG4108TY5 Exhibits lactonase activity. Acts in cells with perturbed membrane integrity and is possibly related to the membrane homeostasis E4W57_RS12530 ENOG4105MVE transcriptional regulator E4W57_RS12535 ENOG4105CMG Carbohydrate kinase E4W57_RS12540 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) E4W57_RS12545 ENOG4105E98 transcriptional regulator DeoR family E4W57_RS12550 ENOG4105UP7 3-epimerase E4W57_RS12555 ENOG4108RVA ribokinase E4W57_RS12560 ENOG4105EDR glucose galactose transporter E4W57_RS12575 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) E4W57_RS12580 ENOG4105CHR reductase E4W57_RS12585 ENOG4105CHU acetyl-coa acetyltransferase E4W57_RS12605 ENOG4105BZW Glycerate kinase E4W57_RS12610 ENOG4107VHA regulatoR E4W57_RS12620 ENOG4105JQN Transcriptional regulator E4W57_RS12630 ENOG4107YCY Transcriptional regulator E4W57_RS12635 ENOG4105CI1 PTS System E4W57_RS12640 ENOG4105F8D glycoside hydrolase family 4 E4W57_RS12645 ENOG4105C54 Major Facilitator superfamily E4W57_RS12650 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein E4W57_RS12665 ENOG4105NIV Esterase E4W57_RS12670 ENOG4105BZU Histidine kinase E4W57_RS12685 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) E4W57_RS12700 ENOG4108VCD Chaperone E4W57_RS12705 ENOG4105CW0 outer membrane usher protein E4W57_RS12715 ENOG4105F32 YngK protein E4W57_RS12720 ENOG4105CAF HipA N-terminal domain protein E4W57_RS12725 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein E4W57_RS12730 ENOG4105VT2 5-hydroxyisourate hydrolase E4W57_RS12735 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) E4W57_RS12740 ENOG4105C2W permease E4W57_RS12745 ENOG41061H0 Monooxygenase E4W57_RS12750 ENOG4108KSA LysR family transcriptional regulator E4W57_RS12770 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions E4W57_RS12785 ENOG4105VYA Uncharacterized conserved protein (DUF2132) E4W57_RS12795 ENOG4105D01 (LipO)protein E4W57_RS12805 ENOG4108UMI ABC transporter, permease E4W57_RS12810 ENOG4105EA8 2-Nitropropane dioxygenase E4W57_RS12815 ENOG4105EGI Transcriptional regulator E4W57_RS12820 ENOG4105CBP Major Facilitator E4W57_RS12830 ENOG4105F9N Major Facilitator Superfamily E4W57_RS12855 ENOG4105M4B Catalyzes the transfer of an acetyl group from acetyl- CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring (By similarity) E4W57_RS12860 ENOG4107QZW Altronate oxidoreductase E4W57_RS12870 ENOG4105BZU Histidine kinase E4W57_RS12875 ENOG4105M0C cytoplasmic protein E4W57_RS12880 ENOG4105CSV Glutaminase E4W57_RS12885 ENOG4105C26 Dehydrogenase E4W57_RS12890 ENOG4105EGI Transcriptional regulator E4W57_RS12900 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) E4W57_RS12905 ENOG4105MVE transcriptional regulator E4W57_RS12910 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) E4W57_RS12915 ENOG4107S2N Type III effector Hrp-dependent E4W57_RS12920 ENOG4105C0A alcohol dehydrogenase E4W57_RS12925 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) E4W57_RS12930 ENOG4108JQ1 Dehydrogenase E4W57_RS12940 ENOG4105JAB phenazine biosynthesis protein, phzf family E4W57_RS12945 ENOG4105F27 Major Facilitator E4W57_RS12950 ENOG41082NP Multiple antibiotic resistance E4W57_RS12960 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes E4W57_RS12965 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF E4W57_RS12970 ENOG4106DNR multiple antibiotic resistance protein E4W57_RS12975 ENOG4108594 Permease of the drug metabolite transporter E4W57_RS12980 ENOG4105E5W Transporter E4W57_RS12990 ENOG4108IV0 ABC, transporter E4W57_RS12995 ENOG4105C0Z ABC transporter E4W57_RS13000 ENOG4105CNN ABC, transporter E4W57_RS13005 ENOG4105C32 Amino acid ABC transporter (Permease) E4W57_RS13025 ENOG4105ECQ AraC Family Transcriptional Regulator E4W57_RS13040 ENOG4105ETE Transcriptional regulator (LacI family E4W57_RS13045 ENOG4105CNT hydrolase family 2 E4W57_RS13050 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) E4W57_RS13055 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) E4W57_RS13070 ENOG4105MVE transcriptional regulator E4W57_RS13080 ENOG4105G63 Type III effector Hrp-dependent E4W57_RS13085 ENOG4105FB2 class II Aldolase E4W57_RS13090 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) E4W57_RS13095 ENOG4105C6Z Gluconate E4W57_RS13115 ENOG4105BZU Histidine kinase E4W57_RS13120 ENOG4108WTK competence damage-inducible protein E4W57_RS13125 ENOG4108ZNX Heat shock protein E4W57_RS13155 ENOG4108RAV Conserved protein E4W57_RS13160 ENOG4105R1U AraC Family Transcriptional Regulator E4W57_RS13170 ENOG4105DGW oligopeptidase A E4W57_RS13175 ENOG4105EMU Dehydrogenase E4W57_RS13180 ENOG4107XBN GntR Family Transcriptional Regulator E4W57_RS13185 ENOG4108U51 Universal stress protein E4W57_RS13190 ENOG4105DEI Mannitol dehydrogenase E4W57_RS13195 ENOG4108I5G Major Facilitator superfamily E4W57_RS13200 ENOG4105KK4 UPF0060 membrane protein E4W57_RS13205 ENOG4105M5Q UPF0482 protein E4W57_RS13210 ENOG4108MK9 spermidine N(1)-acetyltransferase E4W57_RS13220 ENOG4105KBG Protein of unknown function (DUF1161) E4W57_RS13225 ENOG4107QY8 reductase E4W57_RS13230 ENOG4105QAX Iron-sulfur E4W57_RS13235 ENOG4107KGK dmso reductase anchor subunit E4W57_RS13240 ENOG4108NEM leader-binding protein dmsD E4W57_RS13245 ENOG4105CMQ Chloride channel E4W57_RS13250 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) E4W57_RS13255 ENOG4105DAG ROK family E4W57_RS13260 ENOG4106NZI LysR family Transcriptional regulator E4W57_RS13265 ENOG4105D94 Major Facilitator Superfamily E4W57_RS13270 ENOG4105CTD carboxy-peptidase E4W57_RS13280 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap E4W57_RS13290 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) E4W57_RS13295 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) E4W57_RS13300 ENOG4105DSF transport protein E4W57_RS13330 ENOG4107TT2 Auxin Efflux Carrier E4W57_RS13335 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase E4W57_RS13340 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase E4W57_RS13345 ENOG4108K70 Transcriptional regulator E4W57_RS13350 ENOG4105DWT malate dehydrogenase (quinone) E4W57_RS13355 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate E4W57_RS13365 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism E4W57_RS13370 ENOG4108MRH transcriptional regulatory protein E4W57_RS13390 ENOG4107GFK fumarate E4W57_RS13400 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase E4W57_RS13405 ENOG4105F2Z 3-oxoadipate enol-lactonase E4W57_RS13410 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase E4W57_RS13415 ENOG4105CHU acetyl-coa acetyltransferase E4W57_RS13420 ENOG4107QNJ CoA-transferase subunit B E4W57_RS13430 ENOG4107HP6 Transcriptional regulator E4W57_RS13435 ENOG4108DG9 Smr protein MutS2 E4W57_RS13440 ENOG4106KR7 LysR family Transcriptional regulator E4W57_RS13450 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B E4W57_RS13455 ENOG4105CFC Transporter E4W57_RS13465 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) E4W57_RS13470 ENOG4105DS0 Transcriptional regulator, Crp Fnr family E4W57_RS13475 ENOG4105Q9Y Universal stress protein E4W57_RS13480 ENOG410671Z uncharacterized protein ydiH E4W57_RS13485 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) E4W57_RS13490 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) E4W57_RS13500 ENOG4105C5D exported protein E4W57_RS13505 ENOG4105D5Q Arginine ornithine antiporter E4W57_RS13510 ENOG410642E Short chain dehydrogenase E4W57_RS13515 ENOG4105RA2 Membrane E4W57_RS13520 ENOG4107EXC regulatoR E4W57_RS13530 ENOG4105JJR Histidine kinase E4W57_RS13540 ENOG4105C9Q fumarate hydratase class II E4W57_RS13545 ENOG4107GFK fumarate E4W57_RS13550 ENOG4105EIP mannose-6-phosphate isomerase E4W57_RS13555 ENOG4106J39 exported protein E4W57_RS13560 ENOG4107P2S Transcriptional regulator E4W57_RS13565 ENOG4105CI1 PTS System E4W57_RS13570 ENOG4105C87 Aminotransferase class I and II E4W57_RS13580 ENOG41061EV selenium-binding protein YdfZ E4W57_RS13595 ENOG41066VF YeeE YedE family protein E4W57_RS13605 ENOG41064WM Uncharacterized protein YcgX E4W57_RS13610 ENOG4105VPI YqaE family transport protein E4W57_RS13615 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase E4W57_RS13620 ENOG4105C26 Dehydrogenase E4W57_RS13630 ENOG4107DB1 DUF218 domain E4W57_RS13635 ENOG4105CSH Transporter E4W57_RS13645 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) E4W57_RS13650 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) E4W57_RS13655 ENOG4105C26 Dehydrogenase E4W57_RS13660 ENOG4105F4X arginine E4W57_RS13665 ENOG4105C8Y Acetylornithine aminotransferase E4W57_RS13675 ENOG4105D82 Glutamate dehydrogenase E4W57_RS13680 ENOG4108FN7 Aldo keto reductase E4W57_RS13685 ENOG410642W LysR family Transcriptional regulator E4W57_RS13705 ENOG4105ENJ RND efflux system, outer membrane lipoprotein E4W57_RS13715 ENOG4105CQ7 ATP-dependent helicase E4W57_RS13720 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) E4W57_RS13730 ENOG4108Z0R Transferase E4W57_RS13735 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein E4W57_RS13740 ENOG4105DZS Phenylacetate-CoA ligase E4W57_RS13745 ENOG4105CHU acetyl-coa acetyltransferase E4W57_RS13750 ENOG4108ZJI phenylacetic acid degradation protein E4W57_RS13755 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase E4W57_RS13760 ENOG4108UKI Enoyl-CoA hydratase E4W57_RS13765 ENOG4105E39 Enoyl-CoA hydratase E4W57_RS13770 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) E4W57_RS13775 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit E4W57_RS13780 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit E4W57_RS13785 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit E4W57_RS13790 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit E4W57_RS13795 ENOG4105DXM phenylacetic acid degradation protein E4W57_RS13800 ENOG4105F11 amine oxidase E4W57_RS13815 ENOG4105C26 Dehydrogenase E4W57_RS13820 ENOG4108WFR AraC Family Transcriptional Regulator E4W57_RS13825 ENOG4105WXT Conserved Protein E4W57_RS13830 ENOG410689M (LipO)protein E4W57_RS13835 ENOG4107H52 Dicarboxylate transport E4W57_RS13840 ENOG4108KF1 Membrane E4W57_RS13845 ENOG4105C5I Dehydrogenase E4W57_RS13850 ENOG41090X5 Heat shock protein hslJ E4W57_RS13855 ENOG4105IKK cytoplasmic protein E4W57_RS13860 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) E4W57_RS13865 ENOG4105FCK Membrane E4W57_RS13875 ENOG4108RW8 Universal stress protein F E4W57_RS13885 ENOG4105C1J atp-dependent rna helicase E4W57_RS13890 ENOG4107RX3 Mg2 transporter protein cora family protein E4W57_RS13895 ENOG4105E98 transcriptional regulator DeoR family E4W57_RS13900 ENOG4105D9R oxidoreductase E4W57_RS13915 ENOG4105C85 amino acid E4W57_RS13920 ENOG4105F7P transcriptional regulator AsnC family E4W57_RS13930 ENOG4105CGF Aromatic amino acid aminotransferase E4W57_RS13935 ENOG4108UMI ABC transporter, permease E4W57_RS13945 ENOG4105D01 (LipO)protein E4W57_RS13985 ENOG4105HEI LysR family (Transcriptional regulator E4W57_RS14010 ENOG4108XFH Transcriptional regulator E4W57_RS14015 ENOG4105F6U Short-chain dehydrogenase reductase Sdr E4W57_RS14080 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit E4W57_RS14090 ENOG4108ZG0 Ompa motb domain protein E4W57_RS14115 ENOG4108Z0Z intracellular protease Pfpi family E4W57_RS14130 ENOG4105CBN LysR family transcriptional regulator E4W57_RS14150 ENOG4107RTG Major Facilitator superfamily E4W57_RS14155 ENOG4105ENX hydrolase E4W57_RS14160 ENOG4105EQ2 LysR family Transcriptional regulator E4W57_RS14175 ENOG4107QSI ABC, transporter E4W57_RS14185 ENOG4105KXI murein peptide amidase A E4W57_RS14190 ENOG4107S8C mandelate racemase muconate lactonizing E4W57_RS14195 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) E4W57_RS14200 ENOG4108KK1 membrane protein AbrB duplication E4W57_RS14205 ENOG4108JU8 Transcriptional regulator E4W57_RS14210 ENOG4105F8D glycoside hydrolase family 4 E4W57_RS14215 ENOG4105W8I Transcriptional regulator E4W57_RS14220 ENOG4106K28 UPF0283 membrane protein E4W57_RS14225 ENOG4105CM6 amino acid regulated cytosolic protein E4W57_RS14230 ENOG4105NNG Peripheral inner membrane phage-shock protein E4W57_RS14235 ENOG4105FM1 phage shock protein C E4W57_RS14240 ENOG4105YYT phage shock protein B E4W57_RS14245 ENOG41087YS Phage shock protein A E4W57_RS14250 ENOG4105E51 psp operon transcriptional activator E4W57_RS14260 ENOG4105CH2 amidohydrolase E4W57_RS14265 ENOG41063ZK Transcriptional Regulator AraC Family E4W57_RS14280 ENOG4108J59 Extracellular solute-binding protein, family 5 E4W57_RS14285 ENOG4108EKA peptide transport system, permease E4W57_RS14290 ENOG4108EU3 peptide transport system, permease E4W57_RS14295 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein E4W57_RS14300 ENOG4108JQ2 peptide transport system atp-binding protein E4W57_RS14305 ENOG4105ETS cytosine purines uracil thiamine allantoin E4W57_RS14315 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH E4W57_RS14320 ENOG4105Q4T oxidoreductase E4W57_RS14325 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) E4W57_RS14335 ENOG4105N2W Transcriptional regulator E4W57_RS14340 ENOG41061RM osmotically inducible lipoprotein E4W57_RS14345 ENOG4108ZJT translation initiation factor, Sui1 E4W57_RS14355 ENOG4105CFV Tetratricopeptide repeat protein E4W57_RS14360 ENOG4105Q4A inner membrane protein yciS E4W57_RS14365 ENOG4105EYK Phosphatidylglycerophosphatase B E4W57_RS14370 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) E4W57_RS14375 ENOG4107QM5 aconitate hydratase E4W57_RS14385 ENOG4107R11 Transcriptional regulator E4W57_RS14390 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) E4W57_RS14395 ENOG4105RKX Protein of unknown function (DUF2498) E4W57_RS14400 ENOG4105ERU peptidase E4W57_RS14410 ENOG4105UBK short-chain dehydrogenase reductase E4W57_RS14415 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase E4W57_RS14425 ENOG4105ETT transcriptional Regulator, LysR family E4W57_RS14435 ENOG4107RTD sua5 ycio yrdc ywlc family protein E4W57_RS14440 ENOG4105DB7 PHP domain protein E4W57_RS14445 ENOG4105CRQ synthase (Component I) E4W57_RS14450 ENOG4108EFP Anthranilate synthase component II E4W57_RS14455 ENOG4105DK0 Indole-3-glycerol phosphate synthase E4W57_RS14460 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) E4W57_RS14465 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) E4W57_RS14490 ENOG4108IU3 tonb-dependent siderophore receptor E4W57_RS14495 ENOG4107E2E PKHD-type hydroxylase E4W57_RS14500 ENOG4105EIF outer membrane protein W E4W57_RS14505 ENOG4105PI0 Ferredoxin E4W57_RS14510 ENOG4108S3I UPF0259 membrane protein E4W57_RS14515 ENOG4107835 probably involved in intracellular septation (By similarity) E4W57_RS14520 ENOG4107RNH Outer membrane receptor FepA E4W57_RS14525 ENOG4105NAU thioesterase Superfamily protein E4W57_RS14530 ENOG4107PN8 YfeABCD locus regulator E4W57_RS14535 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 E4W57_RS14540 ENOG4105CHR reductase E4W57_RS14545 ENOG4107K5X Membrane-bound metal-dependent hydrolase E4W57_RS14550 ENOG4108ETY sodium dicarboxylate symporter E4W57_RS14555 ENOG4105R8J Activates the cell division inhibited by chromosomal DNA over-replication (By similarity) E4W57_RS14560 ENOG4105CH6 catalase E4W57_RS14565 ENOG410901P UPF0249 protein E4W57_RS14570 ENOG4105F8D glycoside hydrolase family 4 E4W57_RS14575 ENOG4105EZV Transcriptional regulator E4W57_RS14580 ENOG4105VCP PTS System E4W57_RS14585 ENOG4105CK1 PTS System E4W57_RS14595 ENOG4105VZJ PTS System E4W57_RS14600 ENOG4105KKI DNA-binding transcriptional activator OsmE E4W57_RS14610 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) E4W57_RS14615 ENOG4108SPG Periplasmic Protein E4W57_RS14625 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) E4W57_RS14630 ENOG4105C26 Dehydrogenase E4W57_RS14635 ENOG4105F4X arginine E4W57_RS14645 ENOG4105CGK Exodeoxyribonuclease III E4W57_RS14650 ENOG4108RSN SNARE associated Golgi E4W57_RS14655 ENOG4108N5C SNARE associated Golgi protein-related protein E4W57_RS14660 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) E4W57_RS14665 ENOG4105VNH ABC transporter solute-binding protein E4W57_RS14670 ENOG4105CXZ ABC transporter, permease E4W57_RS14675 ENOG4108VGW abc transporter atp-binding protein E4W57_RS14680 ENOG4107RM6 sulfurtransferase E4W57_RS14685 ENOG4108T9J Cdp-alcohol phosphatidyltransferase E4W57_RS14690 ENOG4105M6F mutator MutT protein E4W57_RS14695 ENOG4105D82 Glutamate dehydrogenase E4W57_RS14705 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) E4W57_RS14710 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) E4W57_RS14715 ENOG4105SBG acid phosphatase E4W57_RS14720 ENOG41069NU Nitroreductase E4W57_RS14725 ENOG4105D07 Signal peptide peptidase, SppA E4W57_RS14730 ENOG4105HDK L-asparaginase E4W57_RS14735 ENOG4108RWI nicotinamidase E4W57_RS14745 ENOG4105N1F Hnh endonuclease E4W57_RS14750 ENOG4105VUT cytoplasmic protein E4W57_RS14755 ENOG4105E0X reductase E4W57_RS14760 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase E4W57_RS14765 ENOG4105DSB aldose 1-epimerase E4W57_RS14770 ENOG4105CV8 reductase E4W57_RS14775 ENOG4105GNX MltA-interacting MipA family protein E4W57_RS14780 ENOG4105CYN Serine protein kinase E4W57_RS14815 ENOG4105F27 Major Facilitator E4W57_RS14820 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr E4W57_RS14825 ENOG4105CBN LysR family transcriptional regulator E4W57_RS14830 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) E4W57_RS14835 ENOG4105KT5 UmuD protein E4W57_RS14840 ENOG4105Y50 Virulence Protein E4W57_RS14845 ENOG4108XNZ glycosyl transferase E4W57_RS14850 ENOG4108KXH Ybak prolyl-tRNA synthetase associated E4W57_RS14855 ENOG4108VMM UPF0756 membrane protein E4W57_RS14860 ENOG4105R1U AraC Family Transcriptional Regulator E4W57_RS14865 ENOG4105DJ2 Major Facilitator Superfamily E4W57_RS14870 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) E4W57_RS14875 ENOG4105EWC Purine nucleoside phosphorylase E4W57_RS14880 ENOG4105K78 MarR family Transcriptional regulator E4W57_RS14885 ENOG4105UCG Domain of unknown function (DUF333) E4W57_RS14890 ENOG410620I Diguanylate cyclase E4W57_RS14895 ENOG4106G4W E4W57_RS14910 ENOG4105S5I Membrane E4W57_RS14915 ENOG4108NIW Leucine export protein LeuE E4W57_RS14920 ENOG4105D1S lipid A biosynthesis E4W57_RS14930 ENOG4105DHT Metal Dependent Phosphohydrolase E4W57_RS14935 ENOG4106TD9 Diguanylate cyclase E4W57_RS14940 ENOG4107RSM transcriptional regulator E4W57_RS14945 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) E4W57_RS14975 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii E4W57_RS14980 ENOG4105C4M (Ubiquinol oxidase) subunit I E4W57_RS14985 ENOG4105WEF catalase E4W57_RS14990 ENOG4108N8X transition metal ion binding E4W57_RS14995 ENOG4108Z9Z response to DNA damage stimulus E4W57_RS15010 ENOG4105E2A Dehydrogenase E4W57_RS15015 ENOG4105XDF Protein of unknown function (DUF1272) E4W57_RS15035 ENOG4108ZHR arsR family transcriptional regulator E4W57_RS15040 ENOG4108HMX isocitrate dehydrogenase (NADP) E4W57_RS15045 ENOG4105BZU Histidine kinase E4W57_RS15050 ENOG4105BZU Histidine kinase E4W57_RS15135 ENOG4105D07 Signal peptide peptidase, SppA E4W57_RS15145 ENOG4105CAR Terminase, large subunit E4W57_RS15175 ENOG4108YV9 Protein of unknown function (DUF2514) E4W57_RS15185 ENOG4105QFS Lysis protein S homolog from lambdoid prophage E4W57_RS15205 ENOG4108MXB Protein of unknown function (DUF968) E4W57_RS15225 ENOG4105D29 Helix-turn-helix type 11 domain protein E4W57_RS15230 ENOG4105CHR reductase E4W57_RS15240 ENOG4105BZU Histidine kinase E4W57_RS15280 ENOG41076J9 exonuclease VIII E4W57_RS15285 ENOG4105QYW Excisionase-like protein from lambdoid prophage 14 E4W57_RS15290 ENOG4108I1J Integrase E4W57_RS15295 ENOG4108HMX isocitrate dehydrogenase (NADP) E4W57_RS15310 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) E4W57_RS15315 ENOG41075W9 High frequency lysogenization protein HflD homolog E4W57_RS15320 ENOG4107QTF adenylosuccinate lyase E4W57_RS15340 ENOG4105IFJ Histidine kinase E4W57_RS15345 ENOG4105EZE Cupin 4 family protein E4W57_RS15365 ENOG4105D38 putrescine abc transporter E4W57_RS15370 ENOG4108HM4 ABC transporter E4W57_RS15380 ENOG4105CEY Amp-dependent synthetase and ligase E4W57_RS15385 ENOG4105CV1 Transketolase (EC 2.2.1.1) E4W57_RS15390 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) E4W57_RS15395 ENOG4108YZG isomerase E4W57_RS15400 ENOG4105VI0 Pts system, glucitol sorbitol-specific E4W57_RS15405 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) E4W57_RS15410 ENOG4105G63 Type III effector Hrp-dependent E4W57_RS15425 ENOG4105DKT Transcriptional regulator E4W57_RS15435 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) E4W57_RS15440 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) E4W57_RS15445 ENOG4105D60 lipoprotein releasing system transmembrane protein E4W57_RS15450 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) E4W57_RS15455 ENOG4105D60 lipoprotein releasing system transmembrane protein E4W57_RS15465 ENOG4108JA2 transcriptioN-repair coupling factor E4W57_RS15470 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein E4W57_RS15475 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction E4W57_RS15485 ENOG4108IND Tetr family transcriptional regulator E4W57_RS15500 ENOG4107MBR 17 kDa surface antigen E4W57_RS15505 ENOG4105CEP NADH dehydrogenase E4W57_RS15510 ENOG4105D0Y UPF0227 protein E4W57_RS15525 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) E4W57_RS15530 ENOG41090DQ Lipoprotein E4W57_RS15535 ENOG4105K59 histidine triad (HIT) protein E4W57_RS15540 ENOG4105CI1 PTS System E4W57_RS15545 ENOG4105F8V Hydrolase, tatD family E4W57_RS15550 ENOG4107QRG dna polymerase iii E4W57_RS15555 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) E4W57_RS15560 ENOG4105HHA aminodeoxychorismate lyase E4W57_RS15565 ENOG4105YAZ 4-amino-4-deoxychorismate lyase E4W57_RS15570 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) E4W57_RS15575 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) E4W57_RS15580 ENOG4105CHR reductase E4W57_RS15585 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase E4W57_RS15590 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) E4W57_RS15595 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) E4W57_RS15600 ENOG4105VGS 50s ribosomal protein l32 E4W57_RS15605 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein E4W57_RS15615 ENOG4105EI2 Pseudouridine synthase E4W57_RS15625 ENOG4107QQB Ribonuclease E E4W57_RS15630 ENOG4105CR8 Transcriptional regulator E4W57_RS15635 ENOG4105EQ0 Major Facilitator superfamily E4W57_RS15640 ENOG4105CJR Integral membrane protein (MviN E4W57_RS15645 ENOG4105EP9 oxidoreductase E4W57_RS15650 ENOG4108YXG UPF0502 protein E4W57_RS15655 ENOG4105D9U N-acetyltransferase E4W57_RS15660 ENOG4105EV4 Multidrug resistance protein mdtH E4W57_RS15665 ENOG4105F3T (LipO)protein E4W57_RS15670 ENOG4105EKE dihydroorotase E4W57_RS15675 ENOG4105MEA DNA damage-inducible protein i E4W57_RS15680 ENOG4105PVA Biofilm formation regulatory protein BssS E4W57_RS15690 ENOG4106974 biofilm formation E4W57_RS15700 ENOG4105D1S lipid A biosynthesis E4W57_RS15710 ENOG4108W47 Acidic protein msyB E4W57_RS15715 ENOG4105NAC (LipO)protein E4W57_RS15720 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) E4W57_RS15730 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) E4W57_RS15745 ENOG4108UQ5 membrane protein YcdZ E4W57_RS15750 ENOG4107XHZ cytoplasmic chaperone TorD family protein E4W57_RS15760 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase E4W57_RS15770 ENOG4105HEI LysR family (Transcriptional regulator E4W57_RS15775 ENOG4105EUB pirin domain protein E4W57_RS15780 ENOG4105CHJ isochorismatase hydrolase E4W57_RS15855 ENOG4108Z33 Thiol disulfide Interchange Protein E4W57_RS15860 ENOG4105D5M phosphate starvation-inducible protein E4W57_RS15865 ENOG4105DBE peroxidase E4W57_RS15870 ENOG410650H (LipO)protein E4W57_RS15880 ENOG4105D9N nucleoside E4W57_RS15890 ENOG4105CK7 Sodium proline symporter E4W57_RS15895 ENOG4105C26 Dehydrogenase E4W57_RS15905 ENOG4108R86 Transcriptional regulator E4W57_RS15910 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) E4W57_RS15920 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) E4W57_RS15925 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) E4W57_RS15930 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) E4W57_RS15935 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) E4W57_RS15940 ENOG4105C2W permease E4W57_RS15950 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 E4W57_RS15965 ENOG4105XH3 E4W57_RS15970 ENOG4105D6F Phosphatase E4W57_RS15980 ENOG4105CHR reductase E4W57_RS15995 ENOG4105CUB amino acid E4W57_RS16000 ENOG4105CFQ glutamine synthetase E4W57_RS16005 ENOG4108Z86 Glutamine amidotransferase E4W57_RS16010 ENOG4107VRI Transcriptional regulator E4W57_RS16015 ENOG4105C26 Dehydrogenase E4W57_RS16020 ENOG4105CJP fad dependent oxidoreductase E4W57_RS16025 ENOG4105EJC lysr family transcriptional regulator E4W57_RS16030 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) E4W57_RS16035 ENOG4105C94 Transporter E4W57_RS16040 ENOG4105DVW rieske (2Fe-2S) E4W57_RS16045 ENOG4105C26 Dehydrogenase E4W57_RS16050 ENOG4105E3J oxidoreductase E4W57_RS16070 ENOG4107QSI ABC, transporter E4W57_RS16075 ENOG4108MN8 Membrane E4W57_RS16085 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 E4W57_RS16090 ENOG4108UQN AraC family transcriptional regulator E4W57_RS16095 ENOG4108V1U phospholipid-binding protein E4W57_RS16100 ENOG4105DR4 Methyltransferase E4W57_RS16105 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) E4W57_RS16125 ENOG4108JJA ABC, transporter E4W57_RS16140 ENOG4105K4P CoA-binding domain protein E4W57_RS16150 ENOG41088T4 Helicase IV E4W57_RS16155 ENOG410901E Membrane E4W57_RS16160 ENOG4105EM2 membrane E4W57_RS16165 ENOG4108RZ1 DNA transformation protein E4W57_RS16170 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) E4W57_RS16175 ENOG4105UYK outer membrane protein a E4W57_RS16180 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) E4W57_RS16185 ENOG4105DAN ATP-dependent protease E4W57_RS16190 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) E4W57_RS16195 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) E4W57_RS16200 ENOG4108Q2G (LipO)protein E4W57_RS16205 ENOG4105DY2 Paraquat-inducible protein b E4W57_RS16210 ENOG4105F1S paraquat-inducible protein a E4W57_RS16215 ENOG4105C5H ABC transporter E4W57_RS16220 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) E4W57_RS16225 ENOG4105QVC MOSC domain-containing protein E4W57_RS16230 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) E4W57_RS16240 ENOG4108UZX fmn reductase E4W57_RS16245 ENOG4105GVF (ABC) transporter E4W57_RS16250 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) E4W57_RS16255 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component E4W57_RS16265 ENOG4105CD8 aminopeptidase N E4W57_RS16270 ENOG4107RH7 Nicotinate phosphoribosyltransferase E4W57_RS16275 ENOG4105CH2 amidohydrolase E4W57_RS16280 ENOG4105CE7 Amidase, hydantoinase carbamoylase family E4W57_RS16285 ENOG4105C44 Serine transporter E4W57_RS16290 ENOG4107RCH Diaminopropionate ammonia-lyase E4W57_RS16300 ENOG4105C5S asparaginyl-tRNA synthetase E4W57_RS16305 ENOG4105ZIT Porin Gram-negative type E4W57_RS16310 ENOG4105CGF Aromatic amino acid aminotransferase E4W57_RS16315 ENOG4105C5X domain protein E4W57_RS16320 ENOG4105EAQ (twin-arginine translocation) pathway signal E4W57_RS16325 ENOG4105DIT ErfK YbiS YcfS YnhG family protein E4W57_RS16330 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) E4W57_RS16335 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) E4W57_RS16340 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) E4W57_RS16345 ENOG4106371 Methyltransferase E4W57_RS16350 ENOG4107S90 membrAne E4W57_RS16355 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups E4W57_RS16360 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) E4W57_RS16365 ENOG4105W49 UPF0434 protein E4W57_RS16370 ENOG4105T0Z Conserved Protein E4W57_RS16375 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) E4W57_RS16380 ENOG4105BZ1 (ABC) transporter E4W57_RS16390 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) E4W57_RS16395 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) E4W57_RS16400 ENOG4105CAT Cytidine monophosphate kinase E4W57_RS16405 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase E4W57_RS16410 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) E4W57_RS16415 ENOG4107VMU Membrane E4W57_RS16420 ENOG4105DDY UPF0142 protein ycaO E4W57_RS16425 ENOG4105TMB Formate nitrite transporter E4W57_RS16430 ENOG4105C6N Formate acetyltransferase E4W57_RS16435 ENOG4105F1A Pyruvate formate-lyase E4W57_RS16440 ENOG4108ISG Major Facilitator E4W57_RS16445 ENOG4107KGK dmso reductase anchor subunit E4W57_RS16450 ENOG4105QAX Iron-sulfur E4W57_RS16455 ENOG4107QY8 reductase E4W57_RS16460 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) E4W57_RS16465 ENOG4105D1H recombination factor protein RarA E4W57_RS16470 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) E4W57_RS16475 ENOG4105CNU cell division protein FtsK E4W57_RS16480 ENOG4105EW9 transcriptional regulator AsnC family E4W57_RS16485 ENOG4105C3M thioredoxin reductase E4W57_RS16490 ENOG4108JJ9 ABC, transporter E4W57_RS16495 ENOG4108JJ8 (ABC) transporter E4W57_RS16500 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) E4W57_RS16505 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) E4W57_RS16510 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit E4W57_RS16515 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) E4W57_RS16520 ENOG4105VEQ Cold shock protein E4W57_RS16530 ENOG4105DJY efflux transporter, rnd family, mfp subunit E4W57_RS16535 ENOG4105CPB ATP-dependent endonuclease of the OLD family E4W57_RS16540 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) E4W57_RS16545 ENOG4105DWU Membrane E4W57_RS16555 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) E4W57_RS16565 ENOG4105C7K acetolactate synthase E4W57_RS16570 ENOG4105C5W Aldolase E4W57_RS16575 ENOG4105CGD Nad-dependent epimerase dehydratase E4W57_RS16580 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase E4W57_RS16585 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase E4W57_RS16595 ENOG41064MM (LipO)protein E4W57_RS16600 ENOG4105E5Z arginine transporter ATP-binding subunit E4W57_RS16605 ENOG4106PMH Extracellular solute-binding protein family 3 E4W57_RS16610 ENOG4105GBT ABC transporter E4W57_RS16615 ENOG4105DMR ABC, transporter E4W57_RS16620 ENOG4106TNF Periplasmic binding protein E4W57_RS16625 ENOG4105BZU Histidine kinase E4W57_RS16630 ENOG4105CK6 Two component transcriptional regulator (Winged helix family E4W57_RS16635 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) E4W57_RS16640 ENOG4105RBQ inner membrane protein ybjO E4W57_RS16645 ENOG4105D38 putrescine abc transporter E4W57_RS16650 ENOG4105F38 ABC transporter, permease E4W57_RS16655 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) E4W57_RS16660 ENOG4107RUE extracellular solute-binding protein family 1 E4W57_RS16665 ENOG4108RMJ sensory transduction regulator E4W57_RS16675 ENOG4108DBC nitroreductase E4W57_RS16680 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress E4W57_RS16685 ENOG41090BQ Glutaredoxin E4W57_RS16690 ENOG4105GWF inner membrane protein YbjM E4W57_RS16700 ENOG4105ZTC transcriptional activator, Ogr delta E4W57_RS16740 ENOG4108C33 Resolvase E4W57_RS16750 ENOG4105UZW Tail fiber assembly protein E4W57_RS16850 ENOG4105ED4 portal protein E4W57_RS16875 ENOG4105VZ1 Replication Protein E4W57_RS16880 ENOG4105DFE Dna adenine methylase E4W57_RS16885 ENOG4105KSC Transcriptional regulator, TraR DksA family E4W57_RS16910 ENOG4105MEH E4W57_RS16925 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) E4W57_RS16930 ENOG4108RFG Tetr family transcriptional regulator E4W57_RS16935 ENOG4106UW1 Major Facilitator superfamily E4W57_RS16940 ENOG4108HCJ Hydrolase E4W57_RS16945 ENOG4107QF7 multi-drug E4W57_RS16950 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase E4W57_RS16955 ENOG4107FB0 transcriptional regulator DeoR family E4W57_RS16960 ENOG4105DZ1 carboxypeptidase E4W57_RS16970 ENOG4108TGY Glutathione S-transferase E4W57_RS16975 ENOG4105D8V Glucose sorbosone dehydrogenase E4W57_RS16980 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway E4W57_RS16985 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) E4W57_RS16990 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) E4W57_RS16995 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component E4W57_RS17000 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component E4W57_RS17005 ENOG4105DEF Extracellular solute-binding protein, family 5 E4W57_RS17010 ENOG4108JQ6 ABC transporter E4W57_RS17015 ENOG4105D44 asparaginase E4W57_RS17020 ENOG4105CVM Molybdenum cofactor synthesis domain protein E4W57_RS17025 ENOG4105D06 uba thif-type nad fad binding protein E4W57_RS17030 ENOG4105F1A Pyruvate formate-lyase E4W57_RS17040 ENOG4108HCJ Hydrolase E4W57_RS17045 ENOG41072TH Protein of unknown function (DUF1479) E4W57_RS17050 ENOG4105ETE Transcriptional regulator (LacI family E4W57_RS17055 ENOG4105DPW Major facilitator superfamily MFS_1 E4W57_RS17065 ENOG4105C5H ABC transporter E4W57_RS17070 ENOG4105M2Z protein tyrosine serine phosphatase E4W57_RS17075 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein E4W57_RS17080 ENOG4108TZY GntR Family Transcriptional Regulator E4W57_RS17085 ENOG4105CS2 ec 3.2.1.21 E4W57_RS17090 ENOG4105F4P )-transporter E4W57_RS17095 ENOG4105KST dependent repressor E4W57_RS17105 ENOG4108I6E Sulfatase E4W57_RS17110 ENOG4108T1M outer membrane protein x E4W57_RS17120 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction E4W57_RS17125 ENOG4107R0W ABC transporter E4W57_RS17130 ENOG4105E5Q amino acid AbC transporter E4W57_RS17135 ENOG4105CDA abc transporter atp-binding protein E4W57_RS17140 ENOG4105D8X mechanosensitive ion channel E4W57_RS17145 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) E4W57_RS17150 ENOG4105EW6 flavin reductase domain protein, FMN-binding E4W57_RS17160 ENOG4105KSC Transcriptional regulator, TraR DksA family E4W57_RS17165 ENOG4105VR4 UPF0379 protein ybiJ E4W57_RS17170 ENOG4108MTB glycosyl transferase family E4W57_RS17175 ENOG4105DVT helicase E4W57_RS17180 ENOG4105C1J atp-dependent rna helicase E4W57_RS17200 ENOG4105DJB Major Facilitator Superfamily E4W57_RS17210 ENOG4108PZW LysR family Transcriptional regulator E4W57_RS17215 ENOG4107MVR Transcriptional regulator E4W57_RS17220 ENOG4105D0S secretion protein (HlyD E4W57_RS17225 ENOG4105CJ1 ABC, transporter E4W57_RS17230 ENOG4107QWP ABC-2 type transporter E4W57_RS17235 ENOG4107QWP ABC-2 type transporter E4W57_RS17240 ENOG4105I9U inner membrane protein ybhQ E4W57_RS17245 ENOG4105X23 Endonuclease Exonuclease phosphatase E4W57_RS17250 ENOG4105DZQ phospholipase D Transphosphatidylase E4W57_RS17255 ENOG4107UXM Membrane E4W57_RS17260 ENOG4105HFZ Membrane E4W57_RS17265 ENOG4108ZAF Molybdopterin E4W57_RS17270 ENOG4105M00 molybdopterin converting factor, subunit 1 E4W57_RS17275 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) E4W57_RS17280 ENOG4108RIR Molybdenum cofactor biosynthesis protein E4W57_RS17285 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) E4W57_RS17290 ENOG4105CHW UPF0052 protein E4W57_RS17295 ENOG4105DIJ Phosphoethanolamine transferase E4W57_RS17300 ENOG4105XJC Two component transcriptional regulator (Winged helix family E4W57_RS17305 ENOG4105ECM Sensor protein basS pmrB E4W57_RS17310 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) E4W57_RS17320 ENOG4108IV0 ABC, transporter E4W57_RS17330 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) E4W57_RS17335 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) E4W57_RS17340 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) E4W57_RS17345 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) E4W57_RS17350 ENOG4108V1U phospholipid-binding protein E4W57_RS17355 ENOG4105C85 amino acid E4W57_RS17360 ENOG4105C84 Histidine ammonia-lyase E4W57_RS17365 ENOG4105CGP Urocanate hydratase E4W57_RS17380 ENOG41088SP formiminoglutamate hydrolase E4W57_RS17385 ENOG4105CI2 imidazolone-5-propionate hydrolase E4W57_RS17390 ENOG4105NBR Pectinesterase E4W57_RS17400 ENOG4108U51 Universal stress protein E4W57_RS17405 ENOG4105ENT Efflux transporter rnd family, mfp subunit E4W57_RS17440 ENOG4108XDN Transcriptional regulator E4W57_RS17445 ENOG4105BZU Histidine kinase E4W57_RS17450 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component E4W57_RS17465 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) E4W57_RS17470 ENOG4108K4B hydrolase E4W57_RS17480 ENOG4105E0C molybdate abc transporter E4W57_RS17485 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein E4W57_RS17495 ENOG4105F4R Transcriptional regulator mode E4W57_RS17500 ENOG4105DKW ABC transporter E4W57_RS17505 ENOG4105CMR udp-glucose 4-epimerase E4W57_RS17510 ENOG4105F0Z galactose-1-phosphate uridylyltransferase E4W57_RS17515 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) E4W57_RS17520 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) E4W57_RS17525 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) E4W57_RS17530 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) E4W57_RS17535 ENOG4105JND homeobox protein E4W57_RS17540 ENOG4105PGM cation diffusion facilitator family transporter E4W57_RS17545 ENOG4106Z1T Nicotinamide Mononucleotide Transporter E4W57_RS17550 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) E4W57_RS17600 ENOG4105UFD tol-pal system protein YbgF E4W57_RS17605 ENOG4105KCK Peptidoglycan-associated lipoprotein E4W57_RS17615 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA E4W57_RS17625 ENOG4105E02 MotA TolQ exbB proton channel E4W57_RS17630 ENOG4107YD3 Thioesterase E4W57_RS17635 ENOG4105KJB cyd operon protein YbgE E4W57_RS17645 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii E4W57_RS17650 ENOG4105C4M (Ubiquinol oxidase) subunit I E4W57_RS17655 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha E4W57_RS17660 ENOG4105CMV Succinyl-CoA synthetase subunit beta E4W57_RS17665 ENOG4105C7S Dehydrogenase E4W57_RS17670 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 E4W57_RS17675 ENOG4105E33 succinate dehydrogenase E4W57_RS17680 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) E4W57_RS17685 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein E4W57_RS17690 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit E4W57_RS17695 ENOG4105BZN citrate synthase E4W57_RS17700 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) E4W57_RS17720 ENOG4105E7W lamb ycsf family protein E4W57_RS17725 ENOG4107R7A Allophanate hydrolase subunit 2 E4W57_RS17730 ENOG4105P4J Allophanate hydrolase, subunit 1 E4W57_RS17735 ENOG4107QNR UPF0135 protein E4W57_RS17740 ENOG4105DUX Transporter E4W57_RS17745 ENOG4105CVP deoxyribo-dipyrimidine photolyase E4W57_RS17750 ENOG4105XIQ Protein of unknown function (DUF2517) E4W57_RS17760 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) E4W57_RS17765 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) E4W57_RS17770 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) E4W57_RS17775 ENOG4105C08 Histidine kinase E4W57_RS17780 ENOG4105EEX Two component transcriptional regulator (Winged helix family E4W57_RS17790 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 E4W57_RS17795 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) E4W57_RS17800 ENOG4105EV9 Alpha Beta Hydrolase E4W57_RS17805 ENOG4105NNH LexA regulated protein E4W57_RS17810 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) E4W57_RS17815 ENOG41090R7 Ferric uptake E4W57_RS17820 ENOG4105CSH Transporter E4W57_RS17825 ENOG4105GX6 (LipO)protein E4W57_RS17830 ENOG4105J5J Outer membrane porin E4W57_RS17840 ENOG4105CX6 glutaminyL-tRNA synthetase E4W57_RS17845 ENOG4105CI1 PTS System E4W57_RS17850 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) E4W57_RS17855 ENOG4105CE4 GlcNAc 6-P deacetylase E4W57_RS17860 ENOG4105E2R ROK family E4W57_RS17865 ENOG4105D4U had-superfamily hydrolase, subfamily iia E4W57_RS17870 ENOG4105CAQ asparagine synthetase E4W57_RS17910 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family E4W57_RS17915 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) E4W57_RS17920 ENOG4105C9A Phoh family E4W57_RS17925 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) E4W57_RS17930 ENOG4108JU5 Magnesium and cobalt efflux protein E4W57_RS17935 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) E4W57_RS17940 ENOG4107RP9 extracellular solute-binding protein, family 3 E4W57_RS17945 ENOG4105EAD ABC transporter E4W57_RS17950 ENOG4105DRP amino acid AbC transporter E4W57_RS17955 ENOG4105CDA abc transporter atp-binding protein E4W57_RS17970 ENOG4107PAI alpha helical protein E4W57_RS17975 ENOG4105C8T Leucyl-tRNA synthetase E4W57_RS17985 ENOG4105DJF DNA polymerase III, delta' subunit E4W57_RS17990 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) E4W57_RS17995 ENOG4108TGR phosphatase E4W57_RS18000 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) E4W57_RS18005 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) E4W57_RS18010 ENOG4105CJN penicillin-binding protein E4W57_RS18015 ENOG4105CNI cell division protein FtsW E4W57_RS18020 ENOG4105K6T rare lipoprotein A E4W57_RS18025 ENOG4105DZ1 carboxypeptidase E4W57_RS18030 ENOG4108Z43 UPF0250 protein E4W57_RS18035 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) E4W57_RS18040 ENOG41064T2 transcriptional regulator, lysR family E4W57_RS18045 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) E4W57_RS18050 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) E4W57_RS18070 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) E4W57_RS18075 ENOG4105CEE C4-dicarboxylate transporter E4W57_RS18080 ENOG4105KTS ribonuclease E4W57_RS18085 ENOG4105NXH GreA GreB family elongation factor E4W57_RS18090 ENOG4108U51 Universal stress protein E4W57_RS18095 ENOG4108JU3 Alkyl hydroperoxide reductase E4W57_RS18100 ENOG4105D3R alkyl hydroperoxide reductase E4W57_RS18105 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase E4W57_RS18110 ENOG4105DQS Transcriptional regulator E4W57_RS18115 ENOG4105BZV Phosphoadenosine phosphosulfate reductase E4W57_RS18120 ENOG4105GTN ParB Domain Protein Nuclease E4W57_RS18125 ENOG4105CHM Aminotransferase E4W57_RS18130 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) E4W57_RS18135 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) E4W57_RS18150 ENOG4105C2J ABC transporter E4W57_RS18160 ENOG4105CNN ABC, transporter E4W57_RS18170 ENOG4108M3J Dehydrogenase E4W57_RS18180 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) E4W57_RS18185 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin E4W57_RS18195 ENOG4105DZC cytosine deaminase E4W57_RS18205 ENOG4105ECY inositol monophosphatase E4W57_RS18210 ENOG4105CXY transporter E4W57_RS18215 ENOG4105D6F Phosphatase E4W57_RS18220 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) E4W57_RS18225 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) E4W57_RS18240 ENOG4105CNN ABC, transporter E4W57_RS18245 ENOG4105C2J ABC transporter E4W57_RS18250 ENOG4107SCQ Iron-containing alcohol dehydrogenase E4W57_RS18255 ENOG4105F6U Short-chain dehydrogenase reductase Sdr E4W57_RS18270 ENOG4105VCD cytoplasmic protein E4W57_RS18275 ENOG4105D22 carbon starvation protein E4W57_RS18280 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) E4W57_RS18285 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase E4W57_RS18290 ENOG4105WQI isochorismatase E4W57_RS18295 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase E4W57_RS18300 ENOG4105E4F Isochorismate synthase E4W57_RS18305 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein E4W57_RS18310 ENOG4105E8G Major facilitator Superfamily E4W57_RS18315 ENOG4105DQ5 transport system permease protein E4W57_RS18320 ENOG4105TVJ transport system, permease E4W57_RS18325 ENOG4105E0A ABC, transporter E4W57_RS18330 ENOG4105C0W non-ribosomal peptide synthetase E4W57_RS18335 ENOG41085A6 mbth domain-containing protein E4W57_RS18340 ENOG4105E93 esterase E4W57_RS18345 ENOG4107RNH Outer membrane receptor FepA E4W57_RS18350 ENOG4108TSE Transferase E4W57_RS18355 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator E4W57_RS18365 ENOG4105C2J ABC transporter E4W57_RS18370 ENOG4105CNN ABC, transporter E4W57_RS18375 ENOG4105DNE Transposase E4W57_RS18380 ENOG4105DKT Transcriptional regulator E4W57_RS18385 ENOG4108HHA Transketolase E4W57_RS18390 ENOG4108IUS Transketolase E4W57_RS18400 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) E4W57_RS18410 ENOG410810E transcriptional regulator, lysR family E4W57_RS18415 ENOG4105CUY Mechanosensitive ion channel E4W57_RS18420 ENOG4108WN0 inhibitor of vertebrate lysozyme E4W57_RS18425 ENOG4105C94 Transporter E4W57_RS18440 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) E4W57_RS18450 ENOG4105DEF Extracellular solute-binding protein, family 5 E4W57_RS18455 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component E4W57_RS18460 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component E4W57_RS18465 ENOG4105C3U ABC transporter E4W57_RS18470 ENOG4108JQ7 (ABC) transporter E4W57_RS18500 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) E4W57_RS18505 ENOG4105EMU Dehydrogenase E4W57_RS18515 ENOG4105GBT ABC transporter E4W57_RS18520 ENOG4105DRP amino acid AbC transporter E4W57_RS18525 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) E4W57_RS18535 ENOG4105CHM Aminotransferase E4W57_RS18540 ENOG4105T38 integral membrane protein E4W57_RS18545 ENOG4105CE7 Amidase, hydantoinase carbamoylase family E4W57_RS18560 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component E4W57_RS18570 ENOG4108J59 Extracellular solute-binding protein, family 5 E4W57_RS18575 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) E4W57_RS18580 ENOG4108T58 Mg2 transport protein CorA E4W57_RS18600 ENOG4105WQ6 Membrane E4W57_RS18605 ENOG4105HFT AraC family transcriptional regulator E4W57_RS18615 ENOG410630P Transcriptional regulator E4W57_RS18620 ENOG4105MSB protein, conserved in bacteria E4W57_RS18625 ENOG4108RCM Nitroreductase E4W57_RS18635 ENOG4108IQ3 PTS system E4W57_RS18645 ENOG4105F3R pts system mannose fructose sorbose family iid E4W57_RS18650 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) E4W57_RS18655 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine E4W57_RS18660 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family E4W57_RS18680 ENOG4105CUY Mechanosensitive ion channel E4W57_RS18685 ENOG4105ETE Transcriptional regulator (LacI family E4W57_RS18695 ENOG4105CK5 oxidoreductase E4W57_RS18705 ENOG4105EAA nucleoside E4W57_RS18710 ENOG4105C85 amino acid E4W57_RS18720 ENOG4108NS2 receptor E4W57_RS18725 ENOG4105C26 Dehydrogenase E4W57_RS18730 ENOG4105CJP fad dependent oxidoreductase E4W57_RS18740 ENOG4105CUB amino acid E4W57_RS18755 ENOG4105R48 this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase E4W57_RS18760 ENOG4105DGU Histone deacetylase E4W57_RS18770 ENOG4108UAJ Transcriptional regulator E4W57_RS18780 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) E4W57_RS18795 ENOG4105CPC Aldo Keto reductase E4W57_RS18800 ENOG4105E89 ABC transporter E4W57_RS18805 ENOG4105CH2 amidohydrolase E4W57_RS18835 ENOG4105EHG Permease protein E4W57_RS18840 ENOG4105E0A ABC, transporter E4W57_RS18845 ENOG4105EFX secretion protein, HlyD family E4W57_RS18850 ENOG4105KK7 inner membrane protein YiaW E4W57_RS18860 ENOG4105D7K pfkb domain protein E4W57_RS18865 ENOG4108M0B Sucrose porin E4W57_RS18870 ENOG4105C5Y PTS System E4W57_RS18875 ENOG4108HKT sucrose-6-phosphate hydrolase E4W57_RS18880 ENOG4105WBN Transcriptional regulator (LacI family E4W57_RS18890 ENOG4108HWV )-transporter E4W57_RS18895 ENOG4105C2J ABC transporter E4W57_RS18935 ENOG4105CRK lysyL-tRNA synthetase E4W57_RS18940 ENOG4105DUX Transporter E4W57_RS18945 ENOG4105CXN decarboxylase E4W57_RS18950 ENOG4105D5Q Arginine ornithine antiporter E4W57_RS18955 ENOG4108M3R transcriptional activator CadC E4W57_RS18965 ENOG4105D1S lipid A biosynthesis E4W57_RS19005 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) E4W57_RS19010 ENOG4105WQ3 Rna-binding protein E4W57_RS19015 ENOG4105C8N cysteinyl-tRNA synthetase E4W57_RS19020 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) E4W57_RS19025 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) E4W57_RS19035 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) E4W57_RS19040 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit E4W57_RS19060 ENOG4105CV6 ABC transporter, permease E4W57_RS19065 ENOG4108I0Y (ABC) transporter E4W57_RS19070 ENOG4108UJV acyl-CoA thioesterase i E4W57_RS19075 ENOG4105E1F short-chain dehydrogenase reductase E4W57_RS19080 ENOG4107QR8 Thioredoxin E4W57_RS19085 ENOG4105C4B ABC transporter, permease E4W57_RS19090 ENOG41083J0 (ABC) transporter E4W57_RS19095 ENOG4107QX8 SPFH domain, Band 7 family protein E4W57_RS19100 ENOG4105G5H Membrane E4W57_RS19105 ENOG4108Z6Z Transcriptional regulator E4W57_RS19110 ENOG4105C59 p-type ATPase E4W57_RS19115 ENOG4105MBR gumn family E4W57_RS19120 ENOG4108Z66 YbaK ebsC protein E4W57_RS19125 ENOG4105CGH 5'-nucleotidase E4W57_RS19130 ENOG4105EU0 Major facilitator Superfamily E4W57_RS19135 ENOG4105CKD glutathione-regulated potassium-efflux system protein E4W57_RS19140 ENOG4107RE1 Inosine-guanosine kinase E4W57_RS19150 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) E4W57_RS19155 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) E4W57_RS19160 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) E4W57_RS19165 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) E4W57_RS19170 ENOG4107QMP dna polymerase iii subunits gamma and tau E4W57_RS19175 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) E4W57_RS19180 ENOG4105WD1 Membrane E4W57_RS19185 ENOG4108URS primosomal replication protein n'' E4W57_RS19190 ENOG4106428 Protein of unknown function (DUF2496) E4W57_RS19200 ENOG4105EGS Mechanosensitive ion channel E4W57_RS19205 ENOG4107XI7 Tetr family transcriptional regulator E4W57_RS19210 ENOG4105C1P efflux transporter, rnd family, mfp subunit E4W57_RS19215 ENOG4105BZS acriflavin resistance protein E4W57_RS19220 ENOG4108UKR Biofilm formation regulator YbaJ E4W57_RS19230 ENOG4108UW5 maltose o-acetyltransferase E4W57_RS19240 ENOG4105GSJ Inner membrane protein ylaC E4W57_RS19255 ENOG4105YK5 50S ribosomal protein L36 E4W57_RS19265 ENOG4105ETE Transcriptional regulator (LacI family E4W57_RS19270 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) E4W57_RS19275 ENOG4105CI1 PTS System E4W57_RS19280 ENOG4105C4C beta-galactosidase E4W57_RS19290 ENOG4105EG2 ABC transporter, permease E4W57_RS19300 ENOG4107FKK extracellular solute-binding protein family 1 E4W57_RS19310 ENOG41066DG (EAL) domain protein E4W57_RS19315 ENOG41090EM Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter E4W57_RS19320 ENOG41061MD high-affinity nickel-transporter E4W57_RS19325 ENOG4108VW9 Membrane E4W57_RS19355 ENOG41080UX Methyltransferase E4W57_RS19360 ENOG4108MNP Glycoprotein polysaccharide metabolism E4W57_RS19365 ENOG4105C29 acyl-CoA thioesterase E4W57_RS19370 ENOG4105BZU Histidine kinase E4W57_RS19375 ENOG4108YZA Nitrogen regulatory protein pii E4W57_RS19380 ENOG4105BZ1 (ABC) transporter E4W57_RS19385 ENOG4105BZ1 (ABC) transporter E4W57_RS19390 ENOG4108XM1 transcriptional regulator AsnC family E4W57_RS19400 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) E4W57_RS19405 ENOG4108NFA extracellular solute-binding protein E4W57_RS19410 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) E4W57_RS19415 ENOG4108TGP Thioesterase superfamily protein E4W57_RS19420 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein E4W57_RS19425 ENOG4105EIN peptidylprolyl cis-trans isomerase E4W57_RS19430 ENOG4105K70 DNA-binding protein E4W57_RS19435 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) E4W57_RS19440 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) E4W57_RS19450 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation E4W57_RS19455 ENOG4105M85 Bola protein E4W57_RS19460 ENOG4105IEY (LipO)protein E4W57_RS19465 ENOG4105EYM Major Facilitator superfamily E4W57_RS19470 ENOG4105E2S oxidase) subunit II E4W57_RS19475 ENOG4105BZ9 Cytochrome C oxidase, subunit I E4W57_RS19480 ENOG4105CCU oxidase (Subunit III) E4W57_RS19485 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) E4W57_RS19490 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) E4W57_RS19500 ENOG4107HP6 Transcriptional regulator E4W57_RS19505 ENOG4105E2X shikimate dehydrogenase E4W57_RS19510 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein E4W57_RS19520 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein E4W57_RS19530 ENOG4105D2S major facilitator superfamily E4W57_RS19535 ENOG4105CIB oxidoreductase Domain protein E4W57_RS19540 ENOG4107RDB Major Facilitator E4W57_RS19550 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) E4W57_RS19555 ENOG4107S0N DJ-1 family E4W57_RS19565 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) E4W57_RS19570 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) E4W57_RS19575 ENOG4105CTB Polyprenyl synthetase E4W57_RS19580 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) E4W57_RS19585 ENOG4105CPC Aldo Keto reductase E4W57_RS19590 ENOG4108ZAI phosphatidylglycerophosphatase a E4W57_RS19595 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) E4W57_RS19600 ENOG4107YIM Involved in the transcription termination process (By similarity) E4W57_RS19605 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) E4W57_RS19610 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) E4W57_RS19615 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) E4W57_RS19620 ENOG4108KIC (LipO)protein E4W57_RS19625 ENOG4105DRB nucleoside-specific channel-forming protein E4W57_RS19640 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) E4W57_RS19645 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) E4W57_RS19650 ENOG4105VIE preprotein translocase, subunit YajC E4W57_RS19655 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) E4W57_RS19660 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) E4W57_RS19670 ENOG4108ZYK Acyl carrier protein phosphodiesterase E4W57_RS19675 ENOG4105D3R alkyl hydroperoxide reductase E4W57_RS19685 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia E4W57_RS19700 ENOG4108MGF sugar kinase E4W57_RS19710 ENOG4105CI2 imidazolone-5-propionate hydrolase E4W57_RS19720 ENOG4105CHJ isochorismatase hydrolase E4W57_RS19725 ENOG4105EQ1 Transcriptional regulator E4W57_RS19730 ENOG4107R28 alpha amylase, catalytic region E4W57_RS19735 ENOG4105C85 amino acid E4W57_RS19740 ENOG4105CWM branched-chain amino acid transport system II carrier protein E4W57_RS19745 ENOG4105BZU Histidine kinase E4W57_RS19750 ENOG4105CK6 Two component transcriptional regulator (Winged helix family E4W57_RS19755 ENOG4107RH8 nuclease SbcCD subunit D E4W57_RS19760 ENOG4105EYH Exonuclease E4W57_RS19765 ENOG4105DKQ ROK family E4W57_RS19770 ENOG4105DH7 May be involved in recombination (By similarity) E4W57_RS19775 ENOG4105NBK UPF0345 protein E4W57_RS19780 ENOG4105HBA AroM protein E4W57_RS19785 ENOG4105SS3 E4W57_RS19790 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) E4W57_RS19795 ENOG4105G4C Periplasmic ligand-binding sensor protein E4W57_RS19800 ENOG4108UPT UPF0178 protein E4W57_RS19805 ENOG4105II7 pyrroline-5-carboxylate reductase E4W57_RS19810 ENOG4105VIF phosphate starvation-inducible protein E4W57_RS19815 ENOG4105G6Z alkaline phosphatase E4W57_RS19835 ENOG4105CPF Cell wall formation (By similarity) E4W57_RS19840 ENOG4105UNH Membrane E4W57_RS19845 ENOG4105FR5 inner membrane protein YaiY E4W57_RS19850 ENOG4107QS8 (LipO)protein E4W57_RS19855 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 E4W57_RS19860 ENOG4108RWI nicotinamidase E4W57_RS19865 ENOG4107R6D beta-lactam binding protein AmpH E4W57_RS19870 ENOG4105D52 delta-aminolevulinic acid dehydratase E4W57_RS19880 ENOG4105E2B Taurine dioxygenase E4W57_RS19885 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component E4W57_RS19890 ENOG4108ETV ABC transporter E4W57_RS19895 ENOG4106FTQ Taurine ABC transporter, periplasmic E4W57_RS19900 ENOG4107QK5 Homocysteine s-methyltransferase E4W57_RS19905 ENOG4108IQI permease E4W57_RS19915 ENOG4105CUB amino acid E4W57_RS19920 ENOG4105CPD ethanolamine ammonia-lyase E4W57_RS19925 ENOG4107FQ9 ethanolamine ammonia-lyase E4W57_RS19940 ENOG4105C32 Amino acid ABC transporter (Permease) E4W57_RS19945 ENOG4105CF8 branched-chain amino acid ABC transporter, permease E4W57_RS19950 ENOG4105C0Z ABC transporter E4W57_RS19955 ENOG4108IV0 ABC, transporter E4W57_RS19965 ENOG4105CT1 (ABC) transporter E4W57_RS19970 ENOG4105CDA abc transporter atp-binding protein E4W57_RS19975 ENOG4105E5Q amino acid AbC transporter E4W57_RS19980 ENOG4105DRP amino acid AbC transporter E4W57_RS19990 ENOG4106PYX Receptor E4W57_RS19995 ENOG4108N3D putative enzyme E4W57_RS20000 ENOG4108NN8 Fimbrial protein E4W57_RS20005 ENOG4108GWT fimbrillin MatB E4W57_RS20010 ENOG4106JB4 Represses expression of the flagellar master operon flhDC, and consequently prevents flagellum biosynthesis and motility. Acts by binding to the regulatory region of the flhDC operon E4W57_RS20020 ENOG4105EHI Phosphonate ABC transporter, periplasmic E4W57_RS20030 ENOG4105S7S phosphonate abc transporter E4W57_RS20050 ENOG4108QBX (LipO)protein E4W57_RS20055 ENOG4105FCK Membrane E4W57_RS20060 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) E4W57_RS20085 ENOG4105CW0 outer membrane usher protein E4W57_RS20090 ENOG4108AF8 Chaperone E4W57_RS20095 ENOG4106EAR Fimbrial protein E4W57_RS20130 ENOG4108T1M outer membrane protein x E4W57_RS20145 ENOG4105CXC rtn protein E4W57_RS20165 ENOG4108VEV chaperone E4W57_RS20190 ENOG4105DTA methyltransferase E4W57_RS20195 ENOG4105YCT UPF0386 protein E4W57_RS20205 ENOG4105D5U fad dependent oxidoreductase E4W57_RS20210 ENOG4105C26 Dehydrogenase E4W57_RS20215 ENOG4108JPW Aminotransferase E4W57_RS20220 ENOG4105C85 amino acid E4W57_RS20225 ENOG4108PVQ transcriptional regulator E4W57_RS20230 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) E4W57_RS20235 ENOG4105V1F Fermentation respiration switch protein E4W57_RS20240 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) E4W57_RS20245 ENOG4105CIN aminoacyl-histidine dipeptidase E4W57_RS20250 ENOG4108HYG acetyltransferase E4W57_RS20255 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) E4W57_RS20270 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) E4W57_RS20275 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) E4W57_RS20280 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) E4W57_RS20285 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) E4W57_RS20290 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) E4W57_RS20295 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) E4W57_RS20300 ENOG4105F7V ErfK ybiS ycfS ynhG family protein E4W57_RS20305 ENOG4105E7A Glutamine amidotransferase E4W57_RS20310 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) E4W57_RS20315 ENOG4107QPN acyl-Coa dehydrogenase E4W57_RS20320 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase E4W57_RS20325 ENOG4108VP3 Lysine exporter protein (LysE YggA) E4W57_RS20330 ENOG41090KR LysR family transcriptional Regulator E4W57_RS20340 ENOG4107RZZ dna polymerase iii epsilon subunit E4W57_RS20345 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) E4W57_RS20350 ENOG4105D1A Methyltransferase E4W57_RS20355 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) E4W57_RS20360 ENOG4105E9H Lytic Murein transglycosylase E4W57_RS20365 ENOG4105F2W methyltransferase E4W57_RS20375 ENOG4105F27 Major Facilitator E4W57_RS20380 ENOG4105HEI LysR family (Transcriptional regulator E4W57_RS20385 ENOG4105CV8 reductase E4W57_RS20420 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase E4W57_RS20425 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) E4W57_RS20430 ENOG4108UMI ABC transporter, permease E4W57_RS20435 ENOG4105D01 (LipO)protein E4W57_RS20440 ENOG4108R8X outer membrane lipoprotein E4W57_RS20445 ENOG4108R96 Methyltransferase, YaeB family E4W57_RS20450 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) E4W57_RS20455 ENOG4108UY0 (LipO)protein E4W57_RS20460 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion E4W57_RS20465 ENOG4108YZN class I peptide chain release factor E4W57_RS20470 ENOG4108VWS Yaeq family E4W57_RS20475 ENOG4105W1I UPF0253 protein E4W57_RS20480 ENOG4105M1T rho-binding antiterminator E4W57_RS20485 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) E4W57_RS20490 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase E4W57_RS20495 ENOG4105CXN decarboxylase E4W57_RS20500 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) E4W57_RS20505 ENOG4105C0B DNA polymerase III (alpha subunit) E4W57_RS20510 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) E4W57_RS20515 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) E4W57_RS20520 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) E4W57_RS20525 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) E4W57_RS20530 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) E4W57_RS20535 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) E4W57_RS20540 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane E4W57_RS20545 ENOG4105DZP Membrane-associated zinc metalloprotease E4W57_RS20550 ENOG4105KNE Phosphatidate cytidylyltransferase E4W57_RS20560 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) E4W57_RS20570 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) E4W57_RS20575 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) E4W57_RS20580 ENOG4105CE9 30S ribosomal protein S2 E4W57_RS20585 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) E4W57_RS20590 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) E4W57_RS20595 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) E4W57_RS20600 ENOG4108T8E UPF0325 protein E4W57_RS20605 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR E4W57_RS20610 ENOG4105C0H protease E4W57_RS20615 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein E4W57_RS20620 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) E4W57_RS20625 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) E4W57_RS20630 ENOG4105EN6 Membrane E4W57_RS20635 ENOG4108YX9 iron--sulfur cluster insertion protein erpA E4W57_RS20640 ENOG4105CMQ Chloride channel E4W57_RS20645 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase E4W57_RS20650 ENOG4105S6R Iron-hydroxamate transporter permease subunit E4W57_RS20655 ENOG4105J76 Periplasmic binding protein E4W57_RS20660 ENOG4105E0A ABC, transporter E4W57_RS20665 ENOG4105E0K tonB-dependent siderophore receptor E4W57_RS20670 ENOG4105BZ4 penicillin-binding protein E4W57_RS20765 ENOG4105CQ7 ATP-dependent helicase E4W57_RS20770 ENOG4107XID 2'-5' rna ligase E4W57_RS20775 ENOG4105PW4 Sugar fermentation stimulation protein homolog E4W57_RS20780 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters E4W57_RS20785 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) E4W57_RS20790 ENOG4105DJ0 Poly(A) Polymerase E4W57_RS20795 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase E4W57_RS20800 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) E4W57_RS20805 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) E4W57_RS20810 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) E4W57_RS20815 ENOG4107BJW polysaccharide deacetylase E4W57_RS20820 ENOG4108YTN IIa component E4W57_RS20825 ENOG4105E3A (ABC) transporter E4W57_RS20830 ENOG4105DA5 (ABC) transporter E4W57_RS20835 ENOG41077A9 carbonic anhydrase E4W57_RS20840 ENOG4108UGV hypoxanthine phosphoribosyltransferase E4W57_RS20850 ENOG4105DZG Dehydrogenase E4W57_RS20855 ENOG4105E3B Multicopper oxidase E4W57_RS20860 ENOG4108ZRK uncharacterized protein yacC E4W57_RS20880 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) E4W57_RS20885 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) E4W57_RS20890 ENOG4108ZIG UPF0231 protein E4W57_RS20895 ENOG4107QIJ Aconitate hydratase 2 E4W57_RS20900 ENOG4108NST exported protein E4W57_RS20915 ENOG4107QN2 dihydrolipoyl dehydrogenase E4W57_RS20920 ENOG4107QSN dihydrolipoamide acetyltransferase E4W57_RS20925 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) E4W57_RS20930 ENOG41073TP transcriptional regulator E4W57_RS20935 ENOG4105C85 amino acid E4W57_RS20940 ENOG4105CT4 transporter E4W57_RS20945 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) E4W57_RS20950 ENOG4106A72 regulatory protein AmpE E4W57_RS20955 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase E4W57_RS20960 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase E4W57_RS20965 ENOG4108ZUW Major pilin subunit E4W57_RS20970 ENOG4107QHF type ii secretion system protein e E4W57_RS20975 ENOG4105D7Q type ii secretion system E4W57_RS20980 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) E4W57_RS20985 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) E4W57_RS20990 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) E4W57_RS20995 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) E4W57_RS21000 ENOG4105M6F mutator MutT protein E4W57_RS21005 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving E4W57_RS21010 ENOG4106Q9Y Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) E4W57_RS21015 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) E4W57_RS21020 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) E4W57_RS21025 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) E4W57_RS21030 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) E4W57_RS21040 ENOG4105DFU Cell wall formation (By similarity) E4W57_RS21045 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) E4W57_RS21050 ENOG4105CNI cell division protein FtsW E4W57_RS21060 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) E4W57_RS21065 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) E4W57_RS21070 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) E4W57_RS21075 ENOG4105CJN penicillin-binding protein E4W57_RS21080 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) E4W57_RS21085 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) E4W57_RS21095 ENOG4107B7Y DNA-binding transcriptional regulator FruR E4W57_RS21100 ENOG4108ZP8 Acetolactate synthase small subunit E4W57_RS21105 ENOG4105C7K acetolactate synthase E4W57_RS21110 ENOG41064T2 transcriptional regulator, lysR family E4W57_RS21120 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) E4W57_RS21130 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) E4W57_RS21135 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) E4W57_RS21150 ENOG4105EMV Major Facilitator E4W57_RS21155 ENOG4105FF2 Type I DHQase E4W57_RS21160 ENOG4105C5Q Transcriptional regulator E4W57_RS21165 ENOG4105DJB Major Facilitator Superfamily E4W57_RS21170 ENOG4105S8Q sugar efflux transporter E4W57_RS21190 ENOG4106SMU thiamine transporter membrane protein E4W57_RS21200 ENOG4108KF1 Membrane E4W57_RS21205 ENOG41063TF transcriptional regulator (AraC E4W57_RS21210 ENOG4105EF1 ribulokinase E4W57_RS21215 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) E4W57_RS21220 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase E4W57_RS21225 ENOG4105CQ2 DNA polymerase E4W57_RS21230 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) E4W57_RS21235 ENOG4105D3G Pseudouridine synthase E4W57_RS21245 ENOG4105D2K citrate carrier protein E4W57_RS21250 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism E4W57_RS21255 ENOG4106YYS transcriptional regulatory protein E4W57_RS21260 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) E4W57_RS21265 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) E4W57_RS21275 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) E4W57_RS21280 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) E4W57_RS21290 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) E4W57_RS21295 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) E4W57_RS21300 ENOG4105CKD glutathione-regulated potassium-efflux system protein E4W57_RS21310 ENOG4105M5B (LipO)protein E4W57_RS21315 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain E4W57_RS21320 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain E4W57_RS21325 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) E4W57_RS21330 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase E4W57_RS21335 ENOG4105CHY citrate lyase, alpha E4W57_RS21340 ENOG4105CI0 Citrate lyase E4W57_RS21345 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) E4W57_RS21350 ENOG4105DUA (citrate (pro-3S)-lyase ligase E4W57_RS21355 ENOG4105D2K citrate carrier protein E4W57_RS21365 ENOG4107QSA Oxaloacetate decarboxylase E4W57_RS21370 ENOG4105D9Q decarboxylase (Beta subunit) E4W57_RS21375 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism E4W57_RS21380 ENOG4106YYS transcriptional regulatory protein E4W57_RS21385 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) E4W57_RS21390 ENOG4105EXG Transcriptional regulator E4W57_RS21400 ENOG4105DU0 nucleoside hydrolase E4W57_RS21405 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) E4W57_RS21410 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase E4W57_RS21415 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) E4W57_RS21425 ENOG4105DTN riboflavin biosynthesis protein ribF E4W57_RS21435 ENOG41063Z6 transcriptional regulator, lysR family E4W57_RS21440 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) E4W57_RS21445 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) E4W57_RS21450 ENOG4105CFG Acts as a chaperone (By similarity) E4W57_RS21455 ENOG4108WTA UPF0412 protein YaaI E4W57_RS21460 ENOG4108QUJ UPF0174 protein YaaW E4W57_RS21465 ENOG4106HK8 GPR1 FUN34 yaaH family protein E4W57_RS21470 ENOG4105CSH Transporter E4W57_RS21475 ENOG4108RIR Molybdenum cofactor biosynthesis protein E4W57_RS21480 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) E4W57_RS21485 ENOG4105BZG amino acid carrier protein E4W57_RS21490 ENOG4105D1Q UPF0246 protein E4W57_RS21500 ENOG4105D98 threonine synthase E4W57_RS21505 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) E4W57_RS21510 ENOG4105CFH Aspartokinase E4W57_RS21520 ENOG4106FVC RNA methyltransferase E4W57_RS21525 ENOG410759A E4W57_RS21530 ENOG41065U4 response regulator E4W57_RS21535 ENOG4105CT7 inner membrane cred family protein E4W57_RS21540 ENOG4105EB3 Histidine kinase E4W57_RS21545 ENOG4105E3W Two component transcriptional regulator (Winged helix family E4W57_RS21550 ENOG4108RH0 Crea protein E4W57_RS21555 ENOG4105UEI Transcriptional Regulator AraC Family E4W57_RS21560 ENOG4105CVJ phosphoglycerate mutase E4W57_RS21565 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) E4W57_RS21570 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) E4W57_RS21575 ENOG4107SC1 transglycosylase E4W57_RS21580 ENOG4105C5H ABC transporter E4W57_RS21585 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase E4W57_RS21590 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) E4W57_RS21595 ENOG4105EAC phosphoserine phosphatase E4W57_RS21600 ENOG41062Z9 Membrane E4W57_RS21605 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) E4W57_RS21620 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) E4W57_RS21630 ENOG4105D9N nucleoside E4W57_RS21635 ENOG4105EYA deoxyribonuclease E4W57_RS21640 ENOG4108NRW Phospholipase, patatin family E4W57_RS21645 ENOG41075IC Protein of unknown function (DUF1328) E4W57_RS21650 ENOG4105K3G Periplasmic Protein E4W57_RS21655 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) E4W57_RS21660 ENOG4105PAD Hydrolase E4W57_RS21665 ENOG4105KEG ribosomal-protein-alanine acetyltransferase E4W57_RS21670 ENOG4108WPU DNA polymerase III subunit psi E4W57_RS21675 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) E4W57_RS21695 ENOG4105YBH Protein of unknown function (DUF1435) E4W57_RS21705 ENOG4106TD9 Diguanylate cyclase E4W57_RS21710 ENOG4108819 ferric iron reductase E4W57_RS21715 ENOG4105CK1 PTS System E4W57_RS21720 ENOG4108UIN ybak prolyl-trna synthetase associated region E4W57_RS21725 ENOG4108T94 DNA-binding transcriptional activator BglJ E4W57_RS21730 ENOG4108N8T regulatoR E4W57_RS21740 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase E4W57_RS21745 ENOG4105DWK Membrane E4W57_RS21750 ENOG4107XM3 UPF0442 protein E4W57_RS21755 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) E4W57_RS21760 ENOG4106CVF DNA replication protein E4W57_RS21765 ENOG4105RI1 glycoprotein receptor E4W57_RS21775 ENOG4105DNE Transposase E4W57_RS21785 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) E4W57_RS21790 ENOG4105F3R pts system mannose fructose sorbose family iid E4W57_RS21795 ENOG4105ETZ PTS System E4W57_RS21800 ENOG4105KPI PTS system sorbose subfamily IIB component E4W57_RS21810 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family E4W57_RS21820 ENOG4105XYF acetyltransferase E4W57_RS21825 ENOG4106KNT transcriptional regulator E4W57_RS21830 ENOG4108RTU Aldolase E4W57_RS21835 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 E4W57_RS21840 ENOG4108IA2 Sodium pantothenate symporter E4W57_RS21865 ENOG4105DG4 malate L-lactate dehydrogenase E4W57_RS21870 ENOG4107QTZ amino acid E4W57_RS21875 ENOG4105CZJ Aldehyde dehydrogenase E4W57_RS21880 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) E4W57_RS21895 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) E4W57_RS21905 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein E4W57_RS21910 ENOG4108V8F Transcriptional regulator, MarR family E4W57_RS21920 ENOG4105ERH Fumarylacetoacetate hydrolase E4W57_RS21930 ENOG4105C26 Dehydrogenase E4W57_RS21935 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase E4W57_RS21950 ENOG4105CNV Aldolase E4W57_RS21960 ENOG4108NKV transcriptional regulator E4W57_RS21965 ENOG4105EFA 4-hydroxyphenylacetate E4W57_RS21970 ENOG4107UWN reductase E4W57_RS21975 ENOG4105D22 carbon starvation protein E4W57_RS21980 ENOG4105VCD cytoplasmic protein E4W57_RS21985 ENOG4105CKI cobalamin synthesis protein E4W57_RS21995 ENOG4105C26 Dehydrogenase E4W57_RS22000 ENOG4105DNE Transposase E4W57_RS22005 ENOG4106AXJ AraC family transcriptional regulator E4W57_RS22015 ENOG4106BRA Membrane E4W57_RS22020 ENOG41083G8 Multidrug resistance protein MdtM E4W57_RS22030 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase E4W57_RS22035 ENOG4105CIZ coA-substrate-specific enzyme activase E4W57_RS22050 ENOG4105EFX secretion protein, HlyD family E4W57_RS22060 ENOG4106DIZ Domain of unknown function (DUF1127) E4W57_RS22065 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family E4W57_RS22075 ENOG41064T2 transcriptional regulator, lysR family E4W57_RS22080 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein E4W57_RS22100 ENOG4105KNY Microcompartments protein E4W57_RS22105 ENOG4105KNY Microcompartments protein E4W57_RS22110 ENOG4105KNY Microcompartments protein E4W57_RS22115 ENOG4105C0A alcohol dehydrogenase E4W57_RS22130 ENOG4105C6N Formate acetyltransferase E4W57_RS22135 ENOG4105F1A Pyruvate formate-lyase E4W57_RS22140 ENOG4105KNY Microcompartments protein E4W57_RS22145 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) E4W57_RS22170 ENOG4105D0S secretion protein (HlyD E4W57_RS22175 ENOG4105CJ1 ABC, transporter E4W57_RS22180 ENOG4105CMI transporter E4W57_RS22210 ENOG4105EZE Cupin 4 family protein E4W57_RS22225 ENOG4105GR3 Histidine kinase E4W57_RS22230 ENOG4105CK6 Two component transcriptional regulator (Winged helix family E4W57_RS22235 ENOG4105ENJ RND efflux system, outer membrane lipoprotein E4W57_RS22240 ENOG410624V efflux system protein E4W57_RS22245 ENOG4105EP1 Efflux transporter rnd family, mfp subunit E4W57_RS22250 ENOG4108IJF Heavy metal efflux pump, CzcA E4W57_RS22260 ENOG4105QNF Outer membrane lipoprotein E4W57_RS22265 ENOG4108XDN Transcriptional regulator E4W57_RS22275 ENOG4107FW0 short-chain dehydrogenase reductase E4W57_RS22290 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase E4W57_RS22310 ENOG4107SEY Conserved Protein E4W57_RS22315 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) E4W57_RS22320 ENOG4105C93 Xylose Isomerase E4W57_RS22325 ENOG4105CT4 transporter E4W57_RS22330 ENOG4105DSG hydrolase family 43 E4W57_RS22350 ENOG4107S6X Glycosyl transferase, family 2 E4W57_RS22420 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures E4W57_RS22425 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles E4W57_RS22430 ENOG4108XS9 dna repair protein E4W57_RS22435 ENOG4105MFG Antirestriction protein E4W57_RS22450 ENOG4105TS0 gtp-binding protein E4W57_RS22475 ENOG4105CVR type I restriction-modification system E4W57_RS22480 ENOG4105EKX Restriction modification system DNA (Specificity E4W57_RS22490 ENOG4105DZR Type I site-specific deoxyribonuclease E4W57_RS22525 ENOG41077A9 carbonic anhydrase E4W57_RS22530 ENOG4105CHH sulfate transporter E4W57_RS22535 ENOG4105DQ4 alcohol dehydrogenase E4W57_RS22545 ENOG4105DRS transport system, permease E4W57_RS22550 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) E4W57_RS22555 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) E4W57_RS22565 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) E4W57_RS22570 ENOG4105F0H myo-inositol catabolism protein E4W57_RS22575 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) E4W57_RS22580 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) E4W57_RS22585 ENOG4105D7K pfkb domain protein E4W57_RS22590 ENOG4105CHC glucokinase (EC 2.7.1.2) E4W57_RS22595 ENOG4105DH8 myo-inositol catabolism E4W57_RS22600 ENOG4105C26 Dehydrogenase E4W57_RS22610 ENOG4105D7A ATP-binding protein E4W57_RS22615 ENOG4108K5H permease YjgP YjgQ family protein E4W57_RS22620 ENOG4108M8S permease YjgP YjgQ family protein E4W57_RS22625 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) E4W57_RS22630 ENOG4105MYG DNA polymerase iii, chi subunit E4W57_RS22635 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) E4W57_RS22640 ENOG4108MJ3 acetyltransferase E4W57_RS22645 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase E4W57_RS22650 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) E4W57_RS22660 ENOG4105FDP GntR family transcriptional regulator E4W57_RS22665 ENOG4105CSX c4-dicarboxylate anaerobic carrier E4W57_RS22670 ENOG4105CI2 imidazolone-5-propionate hydrolase E4W57_RS22675 ENOG4108KPW sugar kinase E4W57_RS22680 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine E4W57_RS22685 ENOG4105XEP YhcH YjgK YiaL family protein E4W57_RS22695 ENOG4105CXT aspartate transcarbamylase E4W57_RS22700 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) E4W57_RS22705 ENOG4105KME endoribonuclease L-psp E4W57_RS22715 ENOG4105D4X repressor E4W57_RS22720 ENOG4105C5Y PTS System E4W57_RS22725 ENOG4105CG3 alpha amylase, catalytic region E4W57_RS22730 ENOG4105CK1 PTS System E4W57_RS22735 ENOG4105F8D glycoside hydrolase family 4 E4W57_RS22755 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase E4W57_RS22760 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) E4W57_RS22765 ENOG4105K4U addiction module toxin, RelE StbE family E4W57_RS22775 ENOG4105EMD TRANSCRIPTIONal E4W57_RS22780 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) E4W57_RS22795 ENOG41069H0 dihydroorotase EC 3.5.2.3 E4W57_RS22825 ENOG4108XVM Cytochrome b(562) E4W57_RS22830 ENOG4105CMS peptidase U62, modulator of DNA gyrase E4W57_RS22835 ENOG4105N42 UPF0307 protein E4W57_RS22850 ENOG4105DFU Cell wall formation (By similarity) E4W57_RS22855 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 E4W57_RS22860 ENOG41062B0 ABC transporter, permease E4W57_RS22865 ENOG4107R9N ABC transporter E4W57_RS22870 ENOG4105C2J ABC transporter E4W57_RS22875 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator E4W57_RS22880 ENOG4105F0N pyrophosphate phospho-hydrolase E4W57_RS22900 ENOG4108ZHD aig2 family E4W57_RS22905 ENOG4105MA0 exported protein E4W57_RS22910 ENOG4105CFU surface antigen E4W57_RS22920 ENOG4105C37 (CBS) domain E4W57_RS22930 ENOG4105C4C beta-galactosidase E4W57_RS22940 ENOG41061GZ Protein of unknown function (DUF1107) E4W57_RS22945 ENOG4108UUE Transcriptional regulator E4W57_RS22950 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase E4W57_RS22955 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic E4W57_RS22960 ENOG4105KVH Transcriptional regulator E4W57_RS22965 ENOG4105ECR NmrA family E4W57_RS22975 ENOG4105DXC membrane E4W57_RS22980 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) E4W57_RS22990 ENOG4108V1T peptidylprolyl cis-trans isomerase E4W57_RS22995 ENOG4105FHY Opacity-associated protein A E4W57_RS23000 ENOG4105K9Q Binds to the 23S rRNA (By similarity) E4W57_RS23005 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) E4W57_RS23010 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) E4W57_RS23015 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) E4W57_RS23020 ENOG4105KIT UPF0379 protein yjfY E4W57_RS23045 ENOG4106ETB IIa component E4W57_RS23055 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC E4W57_RS23070 ENOG4108MXZ Esterase E4W57_RS23075 ENOG4105WSB biofilm stress and motility protein A E4W57_RS23080 ENOG4105S17 UPF0379 protein yjfN E4W57_RS23085 ENOG4105CSU acyl-Coa dehydrogenase E4W57_RS23090 ENOG4105C2N RNA methyltransferase TrmH family group 3 E4W57_RS23095 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) E4W57_RS23100 ENOG4105KPV Transcriptional regulator E4W57_RS23105 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis E4W57_RS23120 ENOG4105EPW hflc protein E4W57_RS23125 ENOG4107QJR hflk protein E4W57_RS23130 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) E4W57_RS23140 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) E4W57_RS23145 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) E4W57_RS23150 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase E4W57_RS23155 ENOG4105K8N protein family UPF0079, ATPase E4W57_RS23160 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) E4W57_RS23165 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) E4W57_RS23185 ENOG4106TNF Periplasmic binding protein E4W57_RS23190 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) E4W57_RS23195 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) E4W57_RS23200 ENOG4105DJ4 phosphatidylserine decarboxylase E4W57_RS23205 ENOG4105EGS Mechanosensitive ion channel E4W57_RS23210 ENOG4107SC7 Inner membrane transporter yjeM E4W57_RS23215 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) E4W57_RS23220 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) E4W57_RS23225 ENOG4105E33 succinate dehydrogenase E4W57_RS23235 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) E4W57_RS23245 ENOG4105KPY Small multidrug resistance protein E4W57_RS23250 ENOG4106BSU Entericidin B E4W57_RS23260 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) E4W57_RS23265 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein E4W57_RS23270 ENOG4105CJZ response regulator E4W57_RS23275 ENOG4108MBX Secretion Protein E4W57_RS23280 ENOG4108JJA ABC, transporter E4W57_RS23290 ENOG4108ZVF (LipO)protein E4W57_RS23300 ENOG4108VCD Chaperone E4W57_RS23305 ENOG4105CW0 outer membrane usher protein E4W57_RS23310 ENOG4105MX3 Fimbrial E4W57_RS23320 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) E4W57_RS23330 ENOG4105DVH amino acid E4W57_RS23335 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 E4W57_RS23340 ENOG4108IJ0 Aspartate ammonia-lyase E4W57_RS23345 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter E4W57_RS23355 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) E4W57_RS23360 ENOG4108SIC Transcriptional regulator E4W57_RS23390 ENOG4108TUY outer membrane protein PgaA E4W57_RS23395 ENOG4107BJW polysaccharide deacetylase E4W57_RS23400 ENOG4105CND Glycosyl transferase, family 2 E4W57_RS23415 ENOG4108ZCF integral membrane protein E4W57_RS23425 ENOG4105DVC DnaJ domain protein E4W57_RS23450 ENOG4105CT4 transporter E4W57_RS23455 ENOG4105F8D glycoside hydrolase family 4 E4W57_RS23460 ENOG4108K2B transcriptional regulator E4W57_RS23465 ENOG4105CSH Transporter E4W57_RS23470 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA E4W57_RS23475 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase E4W57_RS23480 ENOG4107RJJ Transcriptional regulator E4W57_RS23485 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG E4W57_RS23490 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH E4W57_RS23495 ENOG4105EKV Phosphonate metabolism protein E4W57_RS23500 ENOG4105FT8 Phosphonate metabolism E4W57_RS23505 ENOG4105ENV phosphonate C-P lyase system protein PhnK E4W57_RS23510 ENOG4105HRV phosphonate c-p lyase system protein phnl E4W57_RS23515 ENOG4105FD8 phosphonate metabolism protein PhnM E4W57_RS23520 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) E4W57_RS23525 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein E4W57_RS23535 ENOG4105BZU Histidine kinase E4W57_RS23540 ENOG4105C2J ABC transporter E4W57_RS23545 ENOG4105CNN ABC, transporter E4W57_RS23550 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator E4W57_RS23580 ENOG41082ND Uncharacterized protein yjcO E4W57_RS23585 ENOG4105CK2 sodium dicarboxylate symporter E4W57_RS23595 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) E4W57_RS23600 ENOG41062QD Membrane E4W57_RS23605 ENOG4107QN1 sodium solute E4W57_RS23620 ENOG4105CW0 outer membrane usher protein E4W57_RS23625 ENOG4108VCD Chaperone E4W57_RS23630 ENOG4105MX3 Fimbrial E4W57_RS23635 ENOG41067MG lrgb family E4W57_RS23645 ENOG4105CMU LysR family (Transcriptional regulator E4W57_RS23650 ENOG4105EEQ Na H antiporter E4W57_RS23655 ENOG4105C7N Xanthine uracil vitamin C permease E4W57_RS23660 ENOG4108K3A Glutathione S-transferase E4W57_RS23665 ENOG4108Z4X TRANSCRIPTIONal E4W57_RS23670 ENOG4108W3Q Transcriptional regulator E4W57_RS23675 ENOG4108M8H domain protein E4W57_RS23680 ENOG4105PMV Membrane E4W57_RS23705 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) E4W57_RS23710 ENOG4105ETE Transcriptional regulator (LacI family E4W57_RS23715 ENOG4105ECY inositol monophosphatase E4W57_RS23725 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane E4W57_RS23740 ENOG4108DMH HTH_ARAC E4W57_RS23745 ENOG4107RNH Outer membrane receptor FepA E4W57_RS23750 ENOG4105E4C Lytic transglycosylase catalytic E4W57_RS23755 ENOG4108UUM single-stranded DNA-binding protein E4W57_RS23760 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) E4W57_RS23765 ENOG4105MSB protein, conserved in bacteria E4W57_RS23770 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme E4W57_RS23780 ENOG4105CGF Aromatic amino acid aminotransferase E4W57_RS23785 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) E4W57_RS23790 ENOG4105CDU Replicative dna helicase E4W57_RS23795 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein E4W57_RS23800 ENOG4105P4Z Phage shock protein G E4W57_RS23805 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) E4W57_RS23815 ENOG4105MYN Zinc uptake regulation protein E4W57_RS23820 ENOG4105VDW Csbd family E4W57_RS23830 ENOG4107R73 Mate efflux family protein E4W57_RS23835 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) E4W57_RS23840 ENOG41080IJ Diacylglycerol kinase E4W57_RS23845 ENOG4105E55 glycerol-3-phosphate acyltransferase E4W57_RS23850 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) E4W57_RS23855 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) E4W57_RS23860 ENOG4107W52 maltose operon periplasmic protein E4W57_RS23865 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) E4W57_RS23870 ENOG4108IJ9 (ABC) transporter E4W57_RS23875 ENOG4107FKK extracellular solute-binding protein family 1 E4W57_RS23880 ENOG4105D56 permease protein E4W57_RS23885 ENOG4105EG2 ABC transporter, permease E4W57_RS23890 ENOG4108VY7 phosphate-starvation-inducible protein PsiE E4W57_RS23895 ENOG4105CEM UPF0597 protein E4W57_RS23910 ENOG4105KME endoribonuclease L-psp E4W57_RS23920 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) E4W57_RS23925 ENOG4107QP8 phosphohexose isomerase E4W57_RS23930 ENOG4105CFH Aspartokinase E4W57_RS23935 ENOG4105C09 Bile acid E4W57_RS23940 ENOG4108ZR5 Conserved Protein E4W57_RS23945 ENOG4105FE9 pseudouridine synthase E4W57_RS23950 ENOG4105DKT Transcriptional regulator E4W57_RS23955 ENOG4105CHR reductase E4W57_RS23960 ENOG4108XCU pts system E4W57_RS23965 ENOG4105KPI PTS system sorbose subfamily IIB component E4W57_RS23970 ENOG4105ETZ PTS System E4W57_RS23975 ENOG4105F3R pts system mannose fructose sorbose family iid E4W57_RS23980 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein E4W57_RS23985 ENOG4105F9E Shikimate 5-dehydrogenase E4W57_RS23990 ENOG4105EAM Na Pi-cotransporter E4W57_RS23995 ENOG4105C3R Methionine synthase E4W57_RS24000 ENOG41069M3 Transcriptional regulator E4W57_RS24005 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) E4W57_RS24010 ENOG4108I9X Isocitrate lyase E4W57_RS24015 ENOG4107QP3 malate synthase g E4W57_RS24020 ENOG4105CVG Homoserine O-transsuccinylase E4W57_RS24025 ENOG4105K5X acetyltransferase E4W57_RS24050 ENOG4105DC1 bifunctional purine biosynthesis protein purh E4W57_RS24055 ENOG4105C12 Phosphoribosylglycinamide synthetase E4W57_RS24065 ENOG4105BZU Histidine kinase E4W57_RS24070 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism E4W57_RS24075 ENOG4108T8B Protein of unknown function (DUF1481) E4W57_RS24080 ENOG4105K70 DNA-binding protein E4W57_RS24085 ENOG4105R2J Conserved Protein E4W57_RS24090 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) E4W57_RS24095 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) E4W57_RS24100 ENOG4105E09 nadh pyrophosphatase E4W57_RS24105 ENOG4107MNS Has binding activity to the major sigma subunit of RNA polymerase. May be involved in replacement of the RNA polymerase sigma subunit from sigma-70 to sigma-S during the transition from exponential growth to the stationary phase (By similarity) E4W57_RS24110 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) E4W57_RS24115 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) E4W57_RS24120 ENOG4105D06 uba thif-type nad fad binding protein E4W57_RS24125 ENOG4105WHD thiamine biosynthesis protein ThiS E4W57_RS24130 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) E4W57_RS24135 ENOG4105D41 biosynthesis protein thiH E4W57_RS24140 ENOG4106TD9 Diguanylate cyclase E4W57_RS24150 ENOG4105VCP PTS System E4W57_RS24155 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter E4W57_RS24160 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) E4W57_RS24165 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) E4W57_RS24170 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) E4W57_RS24175 ENOG4108VZM 50s ribosomal protein L10 E4W57_RS24180 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) E4W57_RS24185 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) E4W57_RS24190 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) E4W57_RS24195 ENOG4105PM1 preprotein translocase subunit SecE E4W57_RS24200 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) E4W57_RS24225 ENOG4105CS9 pantothenic acid kinase E4W57_RS24230 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase E4W57_RS24265 ENOG4108RR8 protoporphyrinogen oxidase E4W57_RS24270 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) E4W57_RS24275 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein E4W57_RS24280 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) E4W57_RS24285 ENOG4108EIM Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities (By similarity) E4W57_RS24290 ENOG4105CHU acetyl-coa acetyltransferase E4W57_RS24295 ENOG4107QK7 reductase E4W57_RS24300 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) E4W57_RS24305 ENOG4105MDZ Transcriptional activator rfaH E4W57_RS24315 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) E4W57_RS24320 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) E4W57_RS24325 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) E4W57_RS24330 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) E4W57_RS24335 ENOG4105JC1 sterol-binding domain protein E4W57_RS24340 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) E4W57_RS24345 ENOG4105CGY Dna recombination protein E4W57_RS24350 ENOG4107SXA Phosphorylase E4W57_RS24355 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) E4W57_RS24360 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) E4W57_RS24365 ENOG4105DZ2 Transcriptional regulator E4W57_RS24370 ENOG4105EMK carboxylate amino acid amine transporter E4W57_RS24375 ENOG4105DQF Hydrolase E4W57_RS24380 ENOG4108EUD Lysophospholipase E4W57_RS24385 ENOG410829K Lysine exporter protein (Lyse ygga) E4W57_RS24395 ENOG4105CCF Lysine exporter protein (Lyse ygga) E4W57_RS24400 ENOG4105C9U ATP-dependent DNA helicase RecQ E4W57_RS24405 ENOG4105HDD phospholipase E4W57_RS24410 ENOG4108VUY thioesterase Superfamily protein E4W57_RS24415 ENOG4105FR1 rard protein E4W57_RS24420 ENOG4107QUT magnesium and cobalt transport protein CorA E4W57_RS24425 ENOG4105C4R Atp-dependent dna helicase E4W57_RS24430 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant E4W57_RS24435 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) E4W57_RS24440 ENOG4105CT0 Protein of unknown function, DUF484 E4W57_RS24450 ENOG4105S7Z (LipO)protein E4W57_RS24455 ENOG4105XQ6 frataxin-like protein E4W57_RS24460 ENOG4107T0K Adenylate cyclase E4W57_RS24465 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) E4W57_RS24470 ENOG41076E6 Uroporphyrinogen-III Synthase E4W57_RS24475 ENOG4105ECF c-methyltransferase E4W57_RS24480 ENOG410601J HemY protein E4W57_RS24505 ENOG4105C85 amino acid E4W57_RS24510 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family E4W57_RS24515 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) E4W57_RS24520 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) E4W57_RS24525 ENOG4105EGZ biosynthesis protein E4W57_RS24530 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase E4W57_RS24535 ENOG4108WJ1 acetyltransferase E4W57_RS24540 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) E4W57_RS24545 ENOG4105C1B dTDP-glucose 4-6-dehydratase E4W57_RS24550 ENOG4107QQG Dehydrogenase E4W57_RS24555 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase E4W57_RS24560 ENOG4105SFE lipopolysaccharide biosynthesis protein E4W57_RS24565 ENOG4105ESV Glycosyl transferase, family 4 E4W57_RS24570 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) E4W57_RS24580 ENOG4105C1J atp-dependent rna helicase E4W57_RS24585 ENOG4105C9X ppx gppa phosphatase E4W57_RS24600 ENOG4108UQV Membrane E4W57_RS24605 ENOG4105C4R Atp-dependent dna helicase E4W57_RS24610 ENOG4105KQ5 peptidylprolyl cis-trans isomerase E4W57_RS24615 ENOG4105KQ5 peptidylprolyl cis-trans isomerase E4W57_RS24620 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase E4W57_RS24625 ENOG4105EMY transcriptional regulator E4W57_RS24630 ENOG4105C7B Threonine dehydratase E4W57_RS24635 ENOG4105C01 Dihydroxy-acid dehydratase E4W57_RS24640 ENOG4105CM2 brancheD-chain amino acid aminotransferase E4W57_RS24645 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit E4W57_RS24660 ENOG4105C0P Mg chelatase subunit ChlI E4W57_RS24665 ENOG4108WFC UPF0438 protein yifE E4W57_RS24720 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) E4W57_RS24725 ENOG4108Y73 Membrane E4W57_RS24730 ENOG4105EJ2 Transcriptional regulator E4W57_RS24735 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) E4W57_RS24740 ENOG4105C5Q Transcriptional regulator E4W57_RS24745 ENOG4105CH7 arginosuccinase E4W57_RS24750 ENOG4105CAS nag kinase E4W57_RS24755 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase E4W57_RS24770 ENOG4108MEK Metal-binding protein YodA E4W57_RS24775 ENOG4106R3P AraC family transcriptional regulator E4W57_RS24780 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) E4W57_RS24785 ENOG4105DCT glycerol dehydrogenase E4W57_RS24790 ENOG4108Q5Y Membrane E4W57_RS24795 ENOG4105SYT Methylenetetrahydrofolate reductase E4W57_RS24800 ENOG4105CN8 Transcriptional regulator E4W57_RS24805 ENOG4108Z8I decarboxylase E4W57_RS24810 ENOG4105CGH 5'-nucleotidase E4W57_RS24820 ENOG4105CFH Aspartokinase E4W57_RS24825 ENOG4105C28 cystathionine E4W57_RS24830 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) E4W57_RS24835 ENOG4105VFB Binds the 23S rRNA (By similarity) E4W57_RS24840 ENOG4105C25 Primosomal protein n' E4W57_RS24845 ENOG4105ETE Transcriptional regulator (LacI family E4W57_RS24850 ENOG41063M6 Cell Division Protein E4W57_RS24855 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) E4W57_RS24865 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase E4W57_RS24870 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) E4W57_RS24875 ENOG4105CTQ phosphohexokinase E4W57_RS24880 ENOG41076HS cation diffusion facilitator family transporter E4W57_RS24885 ENOG4105FMW periplasmic E4W57_RS24890 ENOG4105E3W Two component transcriptional regulator (Winged helix family E4W57_RS24895 ENOG4105E0F Histidine kinase E4W57_RS24900 ENOG4108RPX mosc domain containing protein E4W57_RS24905 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) E4W57_RS24910 ENOG4107YRA Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) (By similarity) E4W57_RS24915 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) E4W57_RS24920 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) E4W57_RS24925 ENOG4105DET Rhamnulokinase E4W57_RS24930 ENOG4105DKG l-rhamnose isomerase E4W57_RS24935 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) E4W57_RS24940 ENOG4105D4B ABC, transporter E4W57_RS24945 ENOG4105C2J ABC transporter E4W57_RS24950 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane E4W57_RS24955 ENOG4105CNN ABC, transporter E4W57_RS24960 ENOG4105C0A alcohol dehydrogenase E4W57_RS24970 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) E4W57_RS25005 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) E4W57_RS25015 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein E4W57_RS25020 ENOG4108MG3 formate dehydrogenase E4W57_RS25025 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) E4W57_RS25035 ENOG41068KX affects formate dehydrogenase-N E4W57_RS25045 ENOG4105SUU thioesterase domain E4W57_RS25050 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) E4W57_RS25055 ENOG4107S2Z UPF0761 membrane protein E4W57_RS25060 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 E4W57_RS25065 ENOG4105CI3 gtp-binding protein typa E4W57_RS25070 ENOG4105C5F glutamine synthetase E4W57_RS25075 ENOG4105CUX Signal transduction histidine kinase E4W57_RS25080 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family E4W57_RS25085 ENOG4106FIY E4W57_RS25090 ENOG4105D4P Coproporphyrinogen iii oxidase E4W57_RS25095 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) E4W57_RS25100 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) E4W57_RS25105 ENOG4105C2M dna polymerase I E4W57_RS25110 ENOG4106HNH Acyl-transferase E4W57_RS25115 ENOG4108Z33 Thiol disulfide Interchange Protein E4W57_RS25120 ENOG4105E27 serine threonine protein kinase E4W57_RS25125 ENOG4105PC1 Conserved Protein E4W57_RS25130 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) E4W57_RS25135 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b E4W57_RS25160 ENOG4107EJG GntR family transcriptional regulator E4W57_RS25165 ENOG4105C0R drug resistance transporter emrb qaca subfamily E4W57_RS25170 ENOG4105ETE Transcriptional regulator (LacI family E4W57_RS25175 ENOG4108RVA ribokinase E4W57_RS25180 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator E4W57_RS25185 ENOG4105CNN ABC, transporter E4W57_RS25190 ENOG4105C2J ABC transporter E4W57_RS25200 ENOG4105DFH Transport of potassium into the cell (By similarity) E4W57_RS25215 ENOG4105CU9 asparagine synthetase A E4W57_RS25220 ENOG4108VVK transcriptional Regulator, AsnC E4W57_RS25225 ENOG4105QTB Flavodoxin E4W57_RS25230 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) E4W57_RS25235 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) E4W57_RS25240 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation E4W57_RS25260 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) E4W57_RS25265 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) E4W57_RS25270 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) E4W57_RS25275 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) E4W57_RS25280 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) E4W57_RS25285 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) E4W57_RS25290 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) E4W57_RS25295 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) E4W57_RS25300 ENOG4105C8U phosphate abc transporter E4W57_RS25305 ENOG4105E2Z phosphate ABC transporter (Permease E4W57_RS25310 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) E4W57_RS25325 ENOG4105DYC esterase E4W57_RS25330 ENOG4107VKM 6-phosphogluconolactonase E4W57_RS25335 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 E4W57_RS25340 ENOG4105C7N Xanthine uracil vitamin C permease E4W57_RS25345 ENOG4108YYH Nadph-dependent fmn reductase E4W57_RS25350 ENOG4105E8Q phosphopantetheinyl transferase E4W57_RS25360 ENOG4105C2C drug resistance transporter, Bcr CflA E4W57_RS25370 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) E4W57_RS25375 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins E4W57_RS25380 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) E4W57_RS25390 ENOG4105VG0 50S ribosomal protein l34 E4W57_RS25405 ENOG410620I Diguanylate cyclase E4W57_RS25425 ENOG4108M8H domain protein E4W57_RS25445 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A E4W57_RS25450 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) E4W57_RS25490 ENOG410624V efflux system protein E4W57_RS25520 ENOG4105DR5 peptidase E4W57_RS25530 ENOG4105E3B Multicopper oxidase E4W57_RS25535 ENOG4105VR0 copper resistance E4W57_RS25540 ENOG4105JDN Copper resistance protein E4W57_RS25545 ENOG4108PG2 copper resistance E4W57_RS25550 ENOG4105CK6 Two component transcriptional regulator (Winged helix family E4W57_RS25555 ENOG4105GR3 Histidine kinase E4W57_RS25590 ENOG4105KF5 hemolysin expression-modulating protein E4W57_RS25605 ENOG4105CZE histidine utilization repressor E4W57_RS25610 ENOG41090B9 response to stress E4W57_RS25615 ENOG4105C84 Histidine ammonia-lyase E4W57_RS25625 ENOG4105E90 ABC transporter E4W57_RS25630 ENOG4105E90 ABC transporter E4W57_RS25635 ENOG4108IJ8 ABC transporter E4W57_RS25645 ENOG4105CGP Urocanate hydratase E4W57_RS25650 ENOG4105ETS cytosine purines uracil thiamine allantoin E4W57_RS25705 ENOG4105C94 Transporter E4W57_RS25755 ENOG4108JEH abc transporter atp-binding protein E4W57_RS25760 ENOG4105E5Q amino acid AbC transporter E4W57_RS25765 ENOG4105E5Q amino acid AbC transporter E4W57_RS25775 ENOG4105ETT transcriptional Regulator, LysR family E4W57_RS25790 ENOG4108SF5 RNA Polymerase E4W57_RS25795 ENOG4108S3W Anti-feci sigma factor, fecr E4W57_RS25800 ENOG4105GAV receptor E4W57_RS25805 ENOG4108HUF Transporter E4W57_RS25810 ENOG4105DQ5 transport system permease protein E4W57_RS25815 ENOG4108IHU transport system permease protein E4W57_RS25820 ENOG4105E0A ABC, transporter E4W57_RS25825 ENOG4108YXQ IS66 Orf2 family protein E4W57_RS25840 ENOG4105EQR Transposase IS116 IS110 IS902 E4W57_RS25845 ENOG4105CIS alcohol dehydrogenase E4W57_RS25850 ENOG4105ETE Transcriptional regulator (LacI family E4W57_RS25860 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) E4W57_RS25890 ENOG4105EQR Transposase IS116 IS110 IS902 E4W57_RS25915 ENOG4108BUD transposase E4W57_RS25925 ENOG4105I1F Resistance protein E4W57_RS25935 ENOG4108BUD transposase E4W57_RS25955 ENOG4108BUD transposase E4W57_RS26005 ENOG4108R0M Aminoglycoside E4W57_RS26020 ENOG4105EQR Transposase IS116 IS110 IS902 E4W57_RS26030 ENOG4108BUD transposase E4W57_RS26065 ENOG4108BUD transposase E4W57_RS26085 ENOG4108BUD transposase E4W57_RS26130 ENOG4108KTG Membrane protein, drug metabolite transporter E4W57_RS26160 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor E4W57_RS26170 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein E4W57_RS26180 ENOG4105WPN DNA integration recombination invertion protein E4W57_RS26230 ENOG4106CQM replication E4W57_RS26290 ENOG4105DZR Type I site-specific deoxyribonuclease E4W57_RS26300 ENOG4106RHG Yeca family E4W57_RS26335 ENOG4107CBI conjugal transfer fertility inhibition protein