locus-tag	class	description
E4W57_RS00020	COG0187	DNA topoisomerase II activity
E4W57_RS00025	COG0561	phosphatase activity
E4W57_RS00040	COG2186	Transcriptional regulator
E4W57_RS00045	COG3734	2-keto-3-deoxy-galactonokinase
E4W57_RS00050	COG0800	Aldolase
E4W57_RS00060	COG2271	Major facilitator Superfamily
E4W57_RS00065	COG0823	Involved in the tonB-independent uptake of proteins
E4W57_RS00070	COG5645	(Lipo)protein
E4W57_RS00085	COG3645	SOS response
E4W57_RS00095	COG2188	Transcriptional regulator
E4W57_RS00110	COG2149	membrane
E4W57_RS00130	COG2610	gluconate transmembrane transporter activity
E4W57_RS00140	COG0583	DNA-binding transcription factor activity
E4W57_RS00145	COG2814	Major facilitator Superfamily
E4W57_RS00175	COG0028	Belongs to the TPP enzyme family
E4W57_RS00180	COG0440	acetolactate synthase activity
E4W57_RS00185	COG2197	response regulator
E4W57_RS00195	COG2271	Major facilitator Superfamily
E4W57_RS00235	COG2188	Transcriptional regulator
E4W57_RS00260	COG4580	involved in the transport of maltose and maltodextrins
E4W57_RS00265	COG1447	Phosphotransferase system cellobiose-specific component IIA
E4W57_RS00270	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4W57_RS00270	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4W57_RS00280	COG1609	Transcriptional regulator
E4W57_RS00290	COG3384	dioxygenase
E4W57_RS00295	COG0583	DNA-binding transcription factor activity
E4W57_RS00300	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E4W57_RS00305	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E4W57_RS00310	COG2828	Protein conserved in bacteria
E4W57_RS00325	COG0697	spore germination
E4W57_RS00330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4W57_RS00330	COG1263	PTS System
E4W57_RS00340	COG2814	Major facilitator Superfamily
E4W57_RS00350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4W57_RS00385	COG0583	DNA-binding transcription factor activity
E4W57_RS00410	COG1464	Belongs to the NlpA lipoprotein family
E4W57_RS00425	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E4W57_RS00435	COG1064	alcohol dehydrogenase
E4W57_RS00470	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4W57_RS00505	COG0582	viral genome integration into host DNA
E4W57_RS00515	COG2211	Major facilitator Superfamily
E4W57_RS00520	COG1501	Belongs to the glycosyl hydrolase 31 family
E4W57_RS00530	COG1486	melibiose metabolic process
E4W57_RS00535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4W57_RS00535	COG1263	PTS System
E4W57_RS00540	COG2982	Protein involved in outer membrane biogenesis
E4W57_RS00545	COG2233	PERMEase
E4W57_RS00550	COG0786	glutamate:sodium symporter activity
E4W57_RS00570	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E4W57_RS00595	COG3152	Membrane
E4W57_RS00605	COG1494	fructose-1,6-bisphosphatase
E4W57_RS00610	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4W57_RS00615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4W57_RS00620	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4W57_RS00640	COG2860	membrane
E4W57_RS00650	COG2169	Transcriptional regulator
E4W57_RS00650	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E4W57_RS00655	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E4W57_RS00660	COG1561	YicC-like family, N-terminal region
E4W57_RS00680	COG1131	(ABC) transporter
E4W57_RS00715	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E4W57_RS00750	COG1519	Transferase
E4W57_RS00755	COG1216	Glycosyl transferase, family 2
E4W57_RS00760	COG0438	transferase activity, transferring glycosyl groups
E4W57_RS00770	COG0859	PFAM glycosyl transferase family 9
E4W57_RS00795	COG0859	PFAM glycosyl transferase family 9
E4W57_RS00810	COG0156	8-amino-7-oxononanoate synthase activity
E4W57_RS00820	COG0463	Glycosyl transferase, family 2
E4W57_RS00825	COG2861	carbohydrate metabolic process
E4W57_RS00830	COG4942	peptidase
E4W57_RS00840	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4W57_RS00845	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E4W57_RS00865	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E4W57_RS00875	COG2186	Transcriptional regulator
E4W57_RS00895	COG3722	fumarate hydratase activity
E4W57_RS00910	COG0625	glutathione transferase activity
E4W57_RS00920	COG3276	selenocysteine insertion sequence binding
E4W57_RS00925	COG0235	Class ii aldolase
E4W57_RS00930	COG3623	hexulose-6-phosphate isomerase
E4W57_RS00935	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
E4W57_RS00940	COG1070	Carbohydrate kinase
E4W57_RS00945	COG2271	Major facilitator Superfamily
E4W57_RS00955	COG2731	YhcH YjgK YiaL family protein
E4W57_RS00965	COG1414	Transcriptional regulator
E4W57_RS00970	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4W57_RS00975	COG3977	Valine--pyruvate aminotransferase
E4W57_RS00980	COG0366	Alpha amylase catalytic
E4W57_RS00985	COG2992	FlgJ-related protein
E4W57_RS00990	COG1609	Transcriptional regulator
E4W57_RS00990	COG2207	Transcriptional regulator
E4W57_RS00995	COG4214	carbohydrate transport
E4W57_RS01005	COG4213	ABC transporter substrate-binding protein
E4W57_RS01020	COG4682	membrane
E4W57_RS01025	COG4682	membrane
E4W57_RS01030	COG3274	enterobacterial common antigen metabolic process
E4W57_RS01055	COG0488	(ABC) transporter
E4W57_RS01060	COG1278	Cold shock
E4W57_RS01065	COG2944	sequence-specific DNA binding
E4W57_RS01070	COG2814	Major facilitator Superfamily
E4W57_RS01090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4W57_RS01100	COG1609	Transcriptional regulator
E4W57_RS01105	COG2885	chlorophyll binding
E4W57_RS01110	COG0243	molybdopterin cofactor binding
E4W57_RS01115	COG0456	acetyltransferase
E4W57_RS01120	COG2818	Glycosylase
E4W57_RS01125	COG5571	outer membrane autotransporter
E4W57_RS01130	COG2223	nitrite transmembrane transporter activity
E4W57_RS01155	COG0747	negative chemotaxis
E4W57_RS01160	COG0601	transmembrane transport
E4W57_RS01165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4W57_RS01170	COG0444	Belongs to the ABC transporter superfamily
E4W57_RS01175	COG4608	Belongs to the ABC transporter superfamily
E4W57_RS01190	COG2894	cell division
E4W57_RS01200	COG1215	transferase activity, transferring glycosyl groups
E4W57_RS01205	COG0457	Tetratricopeptide repeat
E4W57_RS01220	COG2194	sulfuric ester hydrolase activity
E4W57_RS01250	COG1215	transferase activity, transferring glycosyl groups
E4W57_RS01255	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
E4W57_RS01260	COG0457	Tetratricopeptide repeat
E4W57_RS01260	COG3118	belongs to the thioredoxin family
E4W57_RS01265	COG2199	diguanylate cyclase activity
E4W57_RS01265	COG2200	EAL domain
E4W57_RS01275	COG0612	Peptidase, M16
E4W57_RS01285	COG2982	Protein involved in outer membrane biogenesis
E4W57_RS01290	COG0477	Major facilitator Superfamily
E4W57_RS01295	COG1295	ribonuclease BN
E4W57_RS01300	COG0583	DNA-binding transcription factor activity
E4W57_RS01305	COG1028	Short-chain dehydrogenase reductase Sdr
E4W57_RS01310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4W57_RS01320	COG1454	alcohol dehydrogenase
E4W57_RS01330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4W57_RS01335	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E4W57_RS01340	COG0671	phosphoesterase, PA-phosphatase related
E4W57_RS01360	COG0589	response to stress
E4W57_RS01370	COG0306	phosphate transporter
E4W57_RS01375	COG2081	HI0933 family
E4W57_RS01380	COG2239	Acts as a magnesium transporter
E4W57_RS01390	COG1124	(ABC) transporter
E4W57_RS01400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4W57_RS01405	COG0601	transmembrane transport
E4W57_RS01410	COG0747	negative chemotaxis
E4W57_RS01420	COG3479	Phenolic acid decarboxylase
E4W57_RS01460	COG0628	permease
E4W57_RS01465	COG0477	Major facilitator Superfamily
E4W57_RS01475	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E4W57_RS01490	COG3714	YhhN family
E4W57_RS01500	COG3776	membrane
E4W57_RS01505	COG0742	ribosomal rna small subunit methyltransferase
E4W57_RS01510	COG0552	protein localization to endoplasmic reticulum
E4W57_RS01515	COG2884	Cell division ATP-binding protein ftsE
E4W57_RS01520	COG2177	Part of the ABC transporter FtsEX involved in
E4W57_RS01535	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E4W57_RS01545	COG0683	leucine binding
E4W57_RS01555	COG0683	leucine binding
E4W57_RS01560	COG0559	Belongs to the binding-protein-dependent transport system permease family
E4W57_RS01610	COG0584	glycerophosphoryl diester phosphodiesterase
E4W57_RS01620	COG0405	Gamma-glutamyltransferase
E4W57_RS01625	COG1247	-acetyltransferase
E4W57_RS01635	COG0673	inositol 2-dehydrogenase activity
E4W57_RS01640	COG1741	Belongs to the pirin family
E4W57_RS01645	COG1609	Transcriptional regulator
E4W57_RS01650	COG3265	gluconokinase activity
E4W57_RS01655	COG2610	gluconate transmembrane transporter activity
E4W57_RS01665	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E4W57_RS01690	COG0058	SHG alpha-glucan phosphorylase activity
E4W57_RS01705	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E4W57_RS01720	COG1349	DNA-binding transcription factor activity
E4W57_RS01730	COG0058	SHG alpha-glucan phosphorylase activity
E4W57_RS01735	COG1640	4-alpha-glucanotransferase
E4W57_RS01740	COG2610	gluconate transmembrane transporter activity
E4W57_RS01750	COG1040	competence protein
E4W57_RS01775	COG1918	ferrous iron import across plasma membrane
E4W57_RS01780	COG2183	response to ionizing radiation
E4W57_RS01785	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4W57_RS01790	COG0745	RESPONSE REGULATOR receiver
E4W57_RS01810	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E4W57_RS01815	COG1011	Hydrolase
E4W57_RS01825	COG0494	nUDIX hydrolase
E4W57_RS01830	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E4W57_RS01855	COG4796	Type ii and iii secretion system protein
E4W57_RS01870	COG3266	domain, Protein
E4W57_RS01875	COG0338	D12 class N6 adenine-specific DNA methyltransferase
E4W57_RS01880	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4W57_RS01905	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4W57_RS01910	COG0402	S-adenosylhomocysteine deaminase activity
E4W57_RS01915	COG0738	Major facilitator superfamily
E4W57_RS01940	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E4W57_RS01945	COG1289	transmembrane transporter activity
E4W57_RS01955	COG1765	OsmC-like protein
E4W57_RS01960	COG3954	Phosphoribulokinase
E4W57_RS01970	COG0429	hydrolase of the alpha beta-hydrolase fold
E4W57_RS01975	COG0488	(ABC) transporter
E4W57_RS01990	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
E4W57_RS01995	COG1047	Peptidyl-prolyl cis-trans
E4W57_RS02005	COG0545	Peptidyl-prolyl cis-trans isomerase
E4W57_RS02010	COG2964	Protein conserved in bacteria
E4W57_RS02065	COG0051	transcription antitermination factor activity, RNA binding
E4W57_RS02090	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E4W57_RS02105	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E4W57_RS02170	COG0201	protein transport
E4W57_RS02195	COG0202	RNA polymerase activity
E4W57_RS02210	COG0789	Transcriptional regulator
E4W57_RS02215	COG3036	rescue of stalled ribosome
E4W57_RS02245	COG0758	DNA mediated transformation
E4W57_RS02255	COG0551	DNA topoisomerase type I activity
E4W57_RS02275	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E4W57_RS02310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4W57_RS02315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4W57_RS02320	COG1309	transcriptional regulator
E4W57_RS02340	COG4145	pantothenate transmembrane transporter activity
E4W57_RS02345	COG3924	membrane
E4W57_RS02350	COG0439	Biotin carboxylase
E4W57_RS02355	COG0511	ligase activity, forming carbon-carbon bonds
E4W57_RS02380	COG2200	EAL domain
E4W57_RS02380	COG2199	diguanylate cyclase activity
E4W57_RS02385	COG1077	Cell shape determining protein MreB Mrl
E4W57_RS02390	COG1792	Involved in formation and maintenance of cell shape
E4W57_RS02395	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E4W57_RS02405	COG1530	ribonuclease E activity
E4W57_RS02410	COG3164	Protein of unknown function
E4W57_RS02415	COG0312	modulator of DNA gyrase
E4W57_RS02420	COG0583	DNA-binding transcription factor activity
E4W57_RS02435	COG1289	transmembrane transporter activity
E4W57_RS02440	COG2732	(Barnase) inhibitor
E4W57_RS02465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4W57_RS02470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4W57_RS02475	COG3105	Protein conserved in bacteria
E4W57_RS02480	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E4W57_RS02500	COG0625	glutathione transferase activity
E4W57_RS02505	COG2969	positive regulation of protein catabolic process
E4W57_RS02515	COG0493	'glutamate synthase
E4W57_RS02520	COG0067	glutamate synthase
E4W57_RS02520	COG0069	glutamate synthase activity
E4W57_RS02520	COG0070	glutamate synthase
E4W57_RS02525	COG1242	4 iron, 4 sulfur cluster binding
E4W57_RS02530	COG2271	Major facilitator Superfamily
E4W57_RS02535	COG1063	alcohol dehydrogenase
E4W57_RS02540	COG1312	Catalyzes the dehydration of D-mannonate
E4W57_RS02545	COG5002	protein histidine kinase activity
E4W57_RS02545	COG2198	Histidine kinase
E4W57_RS02545	COG0784	Response regulator, receiver
E4W57_RS02550	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
E4W57_RS02555	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4W57_RS02560	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4W57_RS02570	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4W57_RS02575	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E4W57_RS02580	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E4W57_RS02585	COG1137	ATPase activity
E4W57_RS02590	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E4W57_RS02595	COG3117	lipopolysaccharide transmembrane transporter activity
E4W57_RS02600	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E4W57_RS02610	COG0530	calcium, potassium:sodium antiporter activity
E4W57_RS02615	COG1127	ABC transporter
E4W57_RS02620	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E4W57_RS02625	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E4W57_RS02630	COG2854	intermembrane phospholipid transfer
E4W57_RS02635	COG3113	response to antibiotic
E4W57_RS02640	COG5007	Belongs to the BolA IbaG family
E4W57_RS02650	COG3423	Transcriptional regulator
E4W57_RS02655	COG0142	geranyltranstransferase activity
E4W57_RS02670	COG0697	spore germination
E4W57_RS02680	COG2027	D-alanyl-D-alanine carboxypeptidase
E4W57_RS02690	COG1534	Rna-binding protein
E4W57_RS02700	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4W57_RS02705	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E4W57_RS02715	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4W57_RS02755	COG0195	Participates in both transcription termination and antitermination
E4W57_RS02800	COG0814	amino acid
E4W57_RS02805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4W57_RS02810	COG0826	peptidase U32
E4W57_RS02815	COG0826	peptidase U32
E4W57_RS02820	COG3154	lipid carrier protein
E4W57_RS02825	COG3153	acetyltransferase
E4W57_RS02840	COG0693	protein deglycase activity
E4W57_RS02845	COG0702	epimerase
E4W57_RS02850	COG0701	Predicted permease
E4W57_RS02855	COG2823	Periplasmic or secreted lipoprotein
E4W57_RS02875	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E4W57_RS02880	COG2721	sulfolactate sulfo-lyase activity
E4W57_RS02885	COG2271	Major facilitator Superfamily
E4W57_RS02895	COG2084	Dehydrogenase
E4W57_RS02900	COG1929	Belongs to the glycerate kinase type-1 family
E4W57_RS02925	COG1741	Belongs to the pirin family
E4W57_RS02930	COG0583	DNA-binding transcription factor activity
E4W57_RS02935	COG3152	Membrane
E4W57_RS02940	COG0435	Glutathione S-transferase
E4W57_RS02945	COG2259	Doxx family
E4W57_RS02955	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
E4W57_RS02960	COG4575	ribosome binding
E4W57_RS02965	COG1422	Protein of unknown function (DUF1090)
E4W57_RS02975	COG0586	Pfam SNARE associated Golgi protein
E4W57_RS02980	COG2186	Transcriptional regulator
E4W57_RS02985	COG2271	Major facilitator Superfamily
E4W57_RS02995	COG2721	sulfolactate sulfo-lyase activity
E4W57_RS03010	COG0861	Integral membrane protein TerC family
E4W57_RS03015	COG0673	inositol 2-dehydrogenase activity
E4W57_RS03020	COG1451	nucleotide metabolic process
E4W57_RS03040	COG1902	pentaerythritol trinitrate reductase activity
E4W57_RS03040	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4W57_RS03090	COG1695	Transcriptional regulator
E4W57_RS03095	COG2375	cellular response to nickel ion
E4W57_RS03110	COG1461	Dihydroxyacetone kinase
E4W57_RS03115	COG2376	Dihydroxyacetone kinase
E4W57_RS03185	COG3247	response to pH
E4W57_RS03195	COG2198	Histidine kinase
E4W57_RS03195	COG2205	protein histidine kinase activity
E4W57_RS03195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4W57_RS03195	COG0784	Response regulator, receiver
E4W57_RS03200	COG2197	response regulator
E4W57_RS03225	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4W57_RS03230	COG0358	DNA primase activity
E4W57_RS03235	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E4W57_RS03300	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E4W57_RS03315	COG4991	sh3 domain protein
E4W57_RS03320	COG3025	triphosphatase activity
E4W57_RS03345	COG2960	long-chain fatty acid transporting porin activity
E4W57_RS03360	COG3384	dioxygenase
E4W57_RS03365	COG0754	glutathionylspermidine amidase activity
E4W57_RS03380	COG0494	nUDIX hydrolase
E4W57_RS03385	COG3151	Protein conserved in bacteria
E4W57_RS03390	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E4W57_RS03395	COG3150	esterase
E4W57_RS03405	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
E4W57_RS03410	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4W57_RS03415	COG0642	Histidine kinase
E4W57_RS03425	COG3111	PFAM Bacterial OB fold (BOF) protein
E4W57_RS03430	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
E4W57_RS03435	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4W57_RS03440	COG0204	Acyl-transferase
E4W57_RS03445	COG2132	Multicopper oxidase
E4W57_RS03450	COG1032	radical SAM domain protein
E4W57_RS03460	COG0656	L-ascorbic acid biosynthetic process
E4W57_RS03465	COG1979	alcohol dehydrogenase
E4W57_RS03470	COG2207	Transcriptional regulator
E4W57_RS03475	COG0586	Pfam SNARE associated Golgi protein
E4W57_RS03480	COG0626	cystathionine gamma-synthase activity
E4W57_RS03490	COG0848	biopolymer transport protein
E4W57_RS03495	COG2211	Major facilitator Superfamily
E4W57_RS03520	COG0625	glutathione transferase activity
E4W57_RS03535	COG0754	glutathionylspermidine amidase activity
E4W57_RS03540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4W57_RS03560	COG0583	DNA-binding transcription factor activity
E4W57_RS03565	COG0626	cystathionine gamma-synthase activity
E4W57_RS03600	COG1811	Na channel or pump
E4W57_RS03605	COG1982	Orn Lys Arg decarboxylase major
E4W57_RS03610	COG2211	Major facilitator Superfamily
E4W57_RS03625	COG1194	a g-specific adenine glycosylase
E4W57_RS03635	COG3171	Protein conserved in bacteria
E4W57_RS03650	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E4W57_RS03650	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4W57_RS03655	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E4W57_RS03660	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4W57_RS03675	COG0762	integral membrane protein
E4W57_RS03680	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4W57_RS03685	COG2805	Type II/IV secretion system protein
E4W57_RS03705	COG0189	ligase activity
E4W57_RS03710	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4W57_RS03715	COG2356	endonuclease I
E4W57_RS03725	COG2814	Major facilitator Superfamily
E4W57_RS03760	COG2146	nitrite reductase [NAD(P)H] activity
E4W57_RS03775	COG1028	Short-chain dehydrogenase reductase Sdr
E4W57_RS03780	COG1414	Transcriptional regulator
E4W57_RS03810	COG1028	Short-chain dehydrogenase reductase Sdr
E4W57_RS03815	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
E4W57_RS03835	COG0501	Belongs to the peptidase M48B family
E4W57_RS03840	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4W57_RS03855	COG0191	fructose-bisphosphate aldolase activity
E4W57_RS03860	COG0668	transmembrane transport
E4W57_RS03870	COG2968	Membrane
E4W57_RS03885	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4W57_RS03890	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4W57_RS03910	COG0006	proline dipeptidase activity
E4W57_RS03915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4W57_RS03920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4W57_RS03940	COG1028	Short-chain dehydrogenase reductase Sdr
E4W57_RS03945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4W57_RS03965	COG2723	6-phospho-beta-galactosidase activity
E4W57_RS03970	COG1737	Transcriptional regulator
E4W57_RS03980	COG1272	protein, Hemolysin III
E4W57_RS03990	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E4W57_RS04000	COG0716	FMN binding
E4W57_RS04005	COG4974	Belongs to the 'phage' integrase family
E4W57_RS04015	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4W57_RS04035	COG4942	peptidase
E4W57_RS04045	COG2814	Major facilitator Superfamily
E4W57_RS04060	COG0667	Aldo Keto reductase
E4W57_RS04105	COG1393	Belongs to the ArsC family
E4W57_RS04110	COG3104	oligopeptide transport
E4W57_RS04120	COG1538	Outer membrane efflux protein
E4W57_RS04125	COG1289	transmembrane transporter activity
E4W57_RS04140	COG3592	Divergent 4Fe-4S mono-cluster
E4W57_RS04145	COG2388	GCN5-related N-acetyl-transferase
E4W57_RS04155	COG3539	Fimbrial protein
E4W57_RS04160	COG3539	Fimbrial protein
E4W57_RS04165	COG3539	Fimbrial protein
E4W57_RS04170	COG3188	usher protein
E4W57_RS04175	COG3121	Chaperone
E4W57_RS04180	COG3539	Fimbrial protein
E4W57_RS04190	COG4974	Belongs to the 'phage' integrase family
E4W57_RS04195	COG0582	viral genome integration into host DNA
E4W57_RS04200	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
E4W57_RS04205	COG1846	Transcriptional regulator
E4W57_RS04210	COG0697	spore germination
E4W57_RS04260	COG0667	Aldo Keto reductase
E4W57_RS04265	COG0814	amino acid
E4W57_RS04280	COG0183	Belongs to the thiolase family
E4W57_RS04290	COG0823	Involved in the tonB-independent uptake of proteins
E4W57_RS04295	COG1028	Short-chain dehydrogenase reductase Sdr
E4W57_RS04300	COG2814	Major facilitator Superfamily
E4W57_RS04335	COG3842	ATPase activity
E4W57_RS04340	COG0395	ABC-type sugar transport system, permease component
E4W57_RS04345	COG1175	transmembrane transport
E4W57_RS04350	COG1917	Cupin 2, conserved barrel domain protein
E4W57_RS04355	COG1794	racemase activity, acting on amino acids and derivatives
E4W57_RS04360	COG0583	DNA-binding transcription factor activity
E4W57_RS04370	COG1609	Transcriptional regulator
E4W57_RS04375	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4W57_RS04380	COG2723	6-phospho-beta-galactosidase activity
E4W57_RS04385	COG2186	Transcriptional regulator
E4W57_RS04395	COG1609	Transcriptional regulator
E4W57_RS04410	COG0667	Aldo Keto reductase
E4W57_RS04420	COG0861	Integral membrane protein TerC family
E4W57_RS04455	COG2165	general secretion pathway protein
E4W57_RS04460	COG4795	General secretion pathway protein
E4W57_RS04470	COG4967	type IV pilus modification protein PilV
E4W57_RS04475	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E4W57_RS04480	COG1025	Belongs to the peptidase M16 family
E4W57_RS04485	COG1074	ATP-dependent DNA helicase activity
E4W57_RS04490	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4W57_RS04500	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E4W57_RS04500	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E4W57_RS04505	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4W57_RS04510	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4W57_RS04540	COG4656	Part of a membrane complex involved in electron transport
E4W57_RS04545	COG1454	alcohol dehydrogenase
E4W57_RS04545	COG1012	belongs to the aldehyde dehydrogenase family
E4W57_RS04735	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
E4W57_RS04740	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4W57_RS04745	COG2166	iron-sulfur cluster assembly
E4W57_RS04750	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4W57_RS04760	COG0583	DNA-binding transcription factor activity
E4W57_RS04765	COG2363	Small membrane protein
E4W57_RS04775	COG1349	DNA-binding transcription factor activity
E4W57_RS04795	COG0738	Major facilitator superfamily
E4W57_RS04800	COG0235	Class ii aldolase
E4W57_RS04805	COG1454	alcohol dehydrogenase
E4W57_RS04825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4W57_RS04840	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E4W57_RS04845	COG2011	ABC-type metal ion transport system permease component
E4W57_RS04850	COG1464	Belongs to the NlpA lipoprotein family
E4W57_RS04855	COG0477	Major facilitator Superfamily
E4W57_RS04865	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4W57_RS04870	COG1760	l-serine dehydratase
E4W57_RS04875	COG0814	amino acid
E4W57_RS04880	COG1611	Belongs to the LOG family
E4W57_RS04895	COG3098	single-species biofilm formation
E4W57_RS04900	COG0564	pseudouridine synthase activity
E4W57_RS04905	COG0716	FMN binding
E4W57_RS04910	COG2271	Major facilitator Superfamily
E4W57_RS04915	COG4948	Mandelate Racemase Muconate Lactonizing
E4W57_RS04920	COG4948	Mandelate Racemase Muconate Lactonizing
E4W57_RS04925	COG1929	Belongs to the glycerate kinase type-1 family
E4W57_RS04930	COG2205	protein histidine kinase activity
E4W57_RS04930	COG3437	response regulator, receiver
E4W57_RS04930	COG3850	Histidine kinase
E4W57_RS04930	COG4999	Histidine kinase
E4W57_RS04940	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4W57_RS04945	COG3956	TIGRFAM MazG family protein
E4W57_RS04965	COG0602	queuosine metabolic process
E4W57_RS04970	COG0720	synthase
E4W57_RS04990	COG2234	aminopeptidase activity
E4W57_RS05050	COG4942	peptidase
E4W57_RS05050	COG1388	LysM domain
E4W57_RS05055	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4W57_RS05080	COG0163	prenyltransferase activity
E4W57_RS05085	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E4W57_RS05120	COG0210	DNA helicase
E4W57_RS05195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4W57_RS05200	COG4558	Periplasmic binding protein
E4W57_RS05205	COG3720	iron ion transport
E4W57_RS05225	COG0679	Auxin Efflux Carrier
E4W57_RS05240	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4W57_RS05245	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4W57_RS05250	COG1121	(ABC) transporter
E4W57_RS05260	COG1609	Transcriptional regulator
E4W57_RS05265	COG1940	carbohydrate kinase activity
E4W57_RS05270	COG1447	Phosphotransferase system cellobiose-specific component IIA
E4W57_RS05280	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4W57_RS05285	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4W57_RS05290	COG4580	involved in the transport of maltose and maltodextrins
E4W57_RS05300	COG2723	6-phospho-beta-galactosidase activity
E4W57_RS05310	COG0309	Hydrogenase expression formation protein (HypE)
E4W57_RS05315	COG0409	Hydrogenase expression formation protein
E4W57_RS05320	COG0298	carbon dioxide binding
E4W57_RS05325	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E4W57_RS05340	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4W57_RS05345	COG0651	ATP synthesis coupled electron transport
E4W57_RS05350	COG0650	Formate hydrogenlyase subunit 4
E4W57_RS05355	COG3261	NADH dehydrogenase
E4W57_RS05355	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
E4W57_RS05360	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4W57_RS05365	COG3260	NADH ubiquinone oxidoreductase 20
E4W57_RS05375	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E4W57_RS05385	COG2723	6-phospho-beta-galactosidase activity
E4W57_RS05390	COG1263	PTS System
E4W57_RS05390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4W57_RS05395	COG1609	Transcriptional regulator
E4W57_RS05400	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4W57_RS05405	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
E4W57_RS05410	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
E4W57_RS05435	COG1349	DNA-binding transcription factor activity
E4W57_RS05440	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4W57_RS05445	COG1028	Short-chain dehydrogenase reductase Sdr
E4W57_RS05455	COG3732	PTS system glucitol sorbitol-specific
E4W57_RS05460	COG3730	PTS system glucitol sorbitol-specific
E4W57_RS05465	COG2951	lytic endotransglycosylase activity
E4W57_RS05475	COG1121	(ABC) transporter
E4W57_RS05480	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4W57_RS05490	COG1546	Belongs to the CinA family
E4W57_RS05510	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E4W57_RS05540	COG2823	Periplasmic or secreted lipoprotein
E4W57_RS05545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4W57_RS05550	COG1238	metal cluster binding
E4W57_RS05570	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4W57_RS05575	COG2814	Major facilitator Superfamily
E4W57_RS05580	COG1566	PFAM secretion protein HlyD family protein
E4W57_RS05585	COG1846	Transcriptional regulator
E4W57_RS05595	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
E4W57_RS05605	COG4176	ABC-type proline glycine betaine transport system permease component
E4W57_RS05620	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4W57_RS05630	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E4W57_RS05635	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4W57_RS05640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4W57_RS05645	COG4575	ribosome binding
E4W57_RS05660	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4W57_RS05675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4W57_RS05680	COG0640	Transcriptional regulator
E4W57_RS05690	COG0583	DNA-binding transcription factor activity
E4W57_RS05695	COG3284	Transcriptional regulator
E4W57_RS05700	COG1012	belongs to the aldehyde dehydrogenase family
E4W57_RS05705	COG3539	Fimbrial protein
E4W57_RS05710	COG3121	Chaperone
E4W57_RS05730	COG3188	usher protein
E4W57_RS05740	COG3539	Fimbrial protein
E4W57_RS05745	COG2197	response regulator
E4W57_RS05760	COG1028	Short-chain dehydrogenase reductase Sdr
E4W57_RS05770	COG0235	Class ii aldolase
E4W57_RS05780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4W57_RS05815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4W57_RS05820	COG2207	Transcriptional regulator
E4W57_RS05820	COG3708	Transcriptional regulator
E4W57_RS05850	COG2867	negative regulation of translational initiation
E4W57_RS05865	COG0497	DNA recombination
E4W57_RS05880	COG4536	flavin adenine dinucleotide binding
E4W57_RS05885	COG4137	Cytochrome C assembly protein
E4W57_RS05890	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4W57_RS05925	COG2885	chlorophyll binding
E4W57_RS05930	COG2199	diguanylate cyclase activity
E4W57_RS05940	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4W57_RS05945	COG1605	Chorismate mutase
E4W57_RS05945	COG0287	Prephenate dehydrogenase
E4W57_RS05955	COG0077	Prephenate dehydratase
E4W57_RS05955	COG1605	Chorismate mutase
E4W57_RS05965	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E4W57_RS05970	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4W57_RS05985	COG0542	response to heat
E4W57_RS06010	COG0477	Major facilitator Superfamily
E4W57_RS06015	COG5544	Lipoprotein
E4W57_RS06020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4W57_RS06035	COG3118	belongs to the thioredoxin family
E4W57_RS06040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4W57_RS06055	COG0513	Belongs to the DEAD box helicase family
E4W57_RS06065	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E4W57_RS06080	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
E4W57_RS06085	COG3026	antisigma factor binding
E4W57_RS06090	COG3086	response to oxidative stress
E4W57_RS06100	COG0681	Belongs to the peptidase S26 family
E4W57_RS06120	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E4W57_RS06130	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4W57_RS06135	COG1737	Transcriptional regulator
E4W57_RS06140	COG0560	Phosphoserine phosphatase
E4W57_RS06155	COG0047	phosphoribosylformylglycinamidine synthase activity
E4W57_RS06155	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4W57_RS06160	COG2205	protein histidine kinase activity
E4W57_RS06165	COG3170	Tfp pilus assembly protein FimV
E4W57_RS06170	COG2204	response regulator
E4W57_RS06175	COG0347	Belongs to the P(II) protein family
E4W57_RS06180	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4W57_RS06180	COG1017	nitric oxide dioxygenase activity
E4W57_RS06190	COG2259	Doxx family
E4W57_RS06195	COG1940	carbohydrate kinase activity
E4W57_RS06200	COG0457	Tetratricopeptide repeat
E4W57_RS06205	COG2814	Major facilitator Superfamily
E4W57_RS06205	COG0477	Major facilitator Superfamily
E4W57_RS06210	COG2017	converts alpha-aldose to the beta-anomer
E4W57_RS06215	COG2814	Major facilitator Superfamily
E4W57_RS06220	COG3711	transcriptional antiterminator
E4W57_RS06230	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
E4W57_RS06260	COG0822	iron-sulfur transferase activity
E4W57_RS06280	COG0633	Ferredoxin
E4W57_RS06285	COG2975	iron-sulfur cluster assembly
E4W57_RS06305	COG2897	thiosulfate sulfurtransferase activity
E4W57_RS06310	COG2373	Large extracellular alpha-helical protein
E4W57_RS06315	COG4953	penicillin-binding protein 1C
E4W57_RS06345	COG2976	Protein conserved in bacteria
E4W57_RS06375	COG1645	bacterial-type flagellum-dependent swarming motility
E4W57_RS06385	COG0517	IMP dehydrogenase activity
E4W57_RS06385	COG0516	GMP reductase activity
E4W57_RS06395	COG3119	arylsulfatase activity
E4W57_RS06400	COG0641	radical SAM
E4W57_RS06420	COG2200	EAL domain
E4W57_RS06435	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4W57_RS06450	COG2723	6-phospho-beta-galactosidase activity
E4W57_RS06460	COG2233	PERMEase
E4W57_RS06475	COG1393	Belongs to the ArsC family
E4W57_RS06480	COG4783	chaperone-mediated protein folding
E4W57_RS06490	COG0628	permease
E4W57_RS06495	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E4W57_RS06500	COG2716	regulation of RNA biosynthetic process
E4W57_RS06510	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E4W57_RS06520	COG2321	neutral zinc metallopeptidase
E4W57_RS06525	COG1444	tRNA N-acetyltransferase activity
E4W57_RS06530	COG0400	carboxylic ester hydrolase activity
E4W57_RS06545	COG1393	Belongs to the ArsC family
E4W57_RS06555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4W57_RS06560	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4W57_RS06560	COG0493	'glutamate synthase
E4W57_RS06570	COG5342	invasion associated locus B
E4W57_RS06575	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4W57_RS06580	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4W57_RS06590	COG4810	utilization protein
E4W57_RS06680	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4W57_RS06700	COG2837	iron assimilation
E4W57_RS06710	COG4150	thiosulfate binding
E4W57_RS06715	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E4W57_RS06720	COG4208	sulfate ABC transporter
E4W57_RS06725	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E4W57_RS06735	COG4319	ketosteroid isomerase
E4W57_RS06770	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E4W57_RS06790	COG3530	Putative quorum-sensing-regulated virulence factor
E4W57_RS06795	COG0385	Bile acid
E4W57_RS06800	COG0583	DNA-binding transcription factor activity
E4W57_RS06825	COG3415	Transposase
E4W57_RS06830	COG3415	Transposase
E4W57_RS06850	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4W57_RS06865	COG0667	Aldo Keto reductase
E4W57_RS06870	COG3961	Belongs to the TPP enzyme family
E4W57_RS06885	COG3279	Response regulator of the LytR AlgR family
E4W57_RS06890	COG3275	phosphorelay sensor kinase activity
E4W57_RS06905	COG0436	Aminotransferase
E4W57_RS06915	COG2807	transmembrane transport
E4W57_RS06920	COG0590	tRNA wobble adenosine to inosine editing
E4W57_RS06925	COG0583	DNA-binding transcription factor activity
E4W57_RS06945	COG2116	formate transmembrane transporter activity
E4W57_RS06950	COG2853	Lipoprotein
E4W57_RS06960	COG3691	Protein conserved in bacteria
E4W57_RS06975	COG2062	phosphohistidine phosphatase, SixA
E4W57_RS07000	COG0730	response to heat
E4W57_RS07005	COG3101	peptidyl-lysine hydroxylation
E4W57_RS07020	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4W57_RS07040	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E4W57_RS07050	COG0586	Pfam SNARE associated Golgi protein
E4W57_RS07060	COG0285	dihydrofolate synthase activity
E4W57_RS07065	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
E4W57_RS07070	COG1286	toxin biosynthetic process
E4W57_RS07075	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E4W57_RS07080	COG0163	prenyltransferase activity
E4W57_RS07105	COG4160	amino acid transport
E4W57_RS07110	COG4598	ABC transporter
E4W57_RS07125	COG1090	epimerase
E4W57_RS07130	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E4W57_RS07135	COG0625	glutathione transferase activity
E4W57_RS07140	COG0625	glutathione transferase activity
E4W57_RS07145	COG0622	Phosphoesterase
E4W57_RS07150	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
E4W57_RS07155	COG0280	phosphate acetyltransferase
E4W57_RS07155	COG0857	belongs to the CobB CobQ family
E4W57_RS07175	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4W57_RS07180	COG0471	metal ion transport
E4W57_RS07180	COG0490	domain, Protein
E4W57_RS07190	COG0436	Aminotransferase
E4W57_RS07195	COG0583	DNA-binding transcription factor activity
E4W57_RS07240	COG0839	Belongs to the complex I subunit 6 family
E4W57_RS07250	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E4W57_RS07255	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4W57_RS07270	COG2153	protein acetylation
E4W57_RS07275	COG1169	isochorismate synthase
E4W57_RS07300	COG0318	PFAM AMP-dependent synthetase and ligase
E4W57_RS07325	COG1414	Transcriptional regulator
E4W57_RS07335	COG2271	Major facilitator Superfamily
E4W57_RS07345	COG0247	lactate metabolic process
E4W57_RS07355	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E4W57_RS07360	COG2271	Major facilitator Superfamily
E4W57_RS07365	COG0584	glycerophosphoryl diester phosphodiesterase
E4W57_RS07370	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4W57_RS07395	COG0784	Response regulator, receiver
E4W57_RS07395	COG2205	protein histidine kinase activity
E4W57_RS07405	COG2198	Histidine kinase
E4W57_RS07405	COG0642	Histidine kinase
E4W57_RS07420	COG2169	Transcriptional regulator
E4W57_RS07420	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E4W57_RS07425	COG3145	DNA-N1-methyladenine dioxygenase activity
E4W57_RS07430	COG4615	Cyclic peptide transporter
E4W57_RS07435	COG2239	Acts as a magnesium transporter
E4W57_RS07440	COG0659	secondary active sulfate transmembrane transporter activity
E4W57_RS07455	COG0628	permease
E4W57_RS07480	COG1349	DNA-binding transcription factor activity
E4W57_RS07485	COG0494	nUDIX hydrolase
E4W57_RS07505	COG1061	Type III restriction enzyme res subunit
E4W57_RS07510	COG1187	pseudouridine synthase activity
E4W57_RS07515	COG2814	Major facilitator Superfamily
E4W57_RS07525	COG4172	Belongs to the ABC transporter superfamily
E4W57_RS07530	COG4239	(ABC) transporter, permease
E4W57_RS07535	COG4174	ABC transporter (Permease)
E4W57_RS07540	COG4166	transmembrane transport
E4W57_RS07545	COG2200	EAL domain
E4W57_RS07550	COG0791	NLP P60 protein
E4W57_RS07555	COG0671	phosphoesterase, PA-phosphatase related
E4W57_RS07560	COG0523	cobalamin synthesis protein
E4W57_RS07565	COG0246	Mannitol dehydrogenase
E4W57_RS07570	COG1312	Catalyzes the dehydration of D-mannonate
E4W57_RS07590	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4W57_RS07590	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4W57_RS07595	COG1105	Belongs to the carbohydrate kinase PfkB family
E4W57_RS07600	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4W57_RS07600	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
E4W57_RS07600	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4W57_RS07610	COG2855	membrane
E4W57_RS07615	COG0583	DNA-binding transcription factor activity
E4W57_RS07620	COG0833	amino acid
E4W57_RS07625	COG4771	TonB-dependent receptor
E4W57_RS07640	COG2311	Membrane
E4W57_RS07655	COG1129	ABC transporter
E4W57_RS07665	COG2949	membrane
E4W57_RS07675	COG1346	cytolysis
E4W57_RS07685	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4W57_RS07690	COG3659	wide pore channel activity
E4W57_RS07705	COG2723	6-phospho-beta-galactosidase activity
E4W57_RS07710	COG1538	Outer membrane efflux protein
E4W57_RS07715	COG0586	Pfam SNARE associated Golgi protein
E4W57_RS07725	COG1686	Belongs to the peptidase S11 family
E4W57_RS07735	COG0277	FAD linked oxidase domain protein
E4W57_RS07740	COG1472	Belongs to the glycosyl hydrolase 3 family
E4W57_RS07745	COG1732	Glycine betaine
E4W57_RS07750	COG1174	glycine betaine transport
E4W57_RS07755	COG1125	glycine betaine transport
E4W57_RS07760	COG1174	glycine betaine transport
E4W57_RS07770	COG3275	phosphorelay sensor kinase activity
E4W57_RS07780	COG4807	Protein conserved in bacteria
E4W57_RS07800	COG5455	response to cobalt ion
E4W57_RS07810	COG2252	PERMEase
E4W57_RS07820	COG0583	DNA-binding transcription factor activity
E4W57_RS07835	COG0351	phosphomethylpyrimidine kinase
E4W57_RS07840	COG1830	Aldolase
E4W57_RS07850	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4W57_RS07875	COG1070	Carbohydrate kinase
E4W57_RS07885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4W57_RS07890	COG4948	Mandelate Racemase Muconate Lactonizing
E4W57_RS07895	COG0747	negative chemotaxis
E4W57_RS07900	COG0601	transmembrane transport
E4W57_RS07910	COG0444	Belongs to the ABC transporter superfamily
E4W57_RS07915	COG4608	Belongs to the ABC transporter superfamily
E4W57_RS07930	COG0745	RESPONSE REGULATOR receiver
E4W57_RS07935	COG2205	protein histidine kinase activity
E4W57_RS07960	COG1301	dicarboxylic acid transport
E4W57_RS07980	COG5002	protein histidine kinase activity
E4W57_RS07985	COG0443	Heat shock 70 kDa protein
E4W57_RS07990	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
E4W57_RS08005	COG2982	Protein involved in outer membrane biogenesis
E4W57_RS08010	COG1253	flavin adenine dinucleotide binding
E4W57_RS08070	COG1215	transferase activity, transferring glycosyl groups
E4W57_RS08085	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E4W57_RS08090	COG0297	glycogen (starch) synthase activity
E4W57_RS08155	COG0438	transferase activity, transferring glycosyl groups
E4W57_RS08160	COG1216	Glycosyl transferase, family 2
E4W57_RS08160	COG1442	glycosyl transferase family 8
E4W57_RS08170	COG0463	Glycosyl transferase, family 2
E4W57_RS08195	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E4W57_RS08225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4W57_RS08230	COG0583	DNA-binding transcription factor activity
E4W57_RS08240	COG0531	amino acid
E4W57_RS08245	COG0640	Transcriptional regulator
E4W57_RS08250	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4W57_RS08255	COG2925	Exonuclease
E4W57_RS08270	COG1289	transmembrane transporter activity
E4W57_RS08290	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E4W57_RS08300	COG1942	4-Oxalocrotonate Tautomerase
E4W57_RS08305	COG0583	DNA-binding transcription factor activity
E4W57_RS08310	COG0095	Lipoate-protein ligase
E4W57_RS08315	COG0477	Major facilitator Superfamily
E4W57_RS08325	COG3300	MHYT domain
E4W57_RS08325	COG5001	Diguanylate cyclase
E4W57_RS08335	COG3615	Tellurite resistance protein tehB
E4W57_RS08360	COG3706	GGDEF domain
E4W57_RS08380	COG0534	Mate efflux family protein
E4W57_RS08390	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4W57_RS08410	COG0604	alcohol dehydrogenase
E4W57_RS08415	COG1309	transcriptional regulator
E4W57_RS08420	COG0025	NhaP-type Na H and K H
E4W57_RS08535	COG3504	Conjugal transfer protein
E4W57_RS08610	COG4771	TonB-dependent receptor
E4W57_RS08615	COG1021	2,3-dihydroxybenzoate-AMP ligase
E4W57_RS08635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4W57_RS08635	COG2226	methyltransferase
E4W57_RS08635	COG3433	isochorismatase activity
E4W57_RS08650	COG1132	(ABC) transporter
E4W57_RS08655	COG2814	Major facilitator Superfamily
E4W57_RS08660	COG1169	isochorismate synthase
E4W57_RS08665	COG0582	viral genome integration into host DNA
E4W57_RS08680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4W57_RS08685	COG0735	belongs to the Fur family
E4W57_RS08695	COG0523	cobalamin synthesis protein
E4W57_RS08720	COG0523	cobalamin synthesis protein
E4W57_RS08750	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4W57_RS08755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4W57_RS08760	COG1121	(ABC) transporter
E4W57_RS08765	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4W57_RS08770	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4W57_RS08780	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4W57_RS08810	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4W57_RS08815	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4W57_RS08820	COG1121	(ABC) transporter
E4W57_RS08830	COG0582	viral genome integration into host DNA
E4W57_RS08850	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4W57_RS08860	COG1418	mRNA catabolic process
E4W57_RS08865	COG0270	DNA (cytosine-5-)-methyltransferase activity
E4W57_RS08870	COG3727	T/G mismatch-specific endonuclease activity
E4W57_RS08875	COG0697	spore germination
E4W57_RS08880	COG2354	Protein conserved in bacteria
E4W57_RS08910	COG0366	Alpha amylase catalytic
E4W57_RS08935	COG2197	response regulator
E4W57_RS08945	COG2197	response regulator
E4W57_RS08980	COG3318	Belongs to the UPF0149 family
E4W57_RS08980	COG3012	SEC-C Motif Domain Protein
E4W57_RS08985	COG0814	amino acid
E4W57_RS08995	COG1528	Iron-storage protein
E4W57_RS09010	COG0477	Major facilitator Superfamily
E4W57_RS09020	COG2211	Major facilitator Superfamily
E4W57_RS09030	COG1528	Iron-storage protein
E4W57_RS09040	COG1879	ABC-type sugar transport system periplasmic component
E4W57_RS09050	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4W57_RS09075	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
E4W57_RS09085	COG3102	Protein conserved in bacteria
E4W57_RS09105	COG3788	relative of glutathione S-transferase, MAPEG superfamily
E4W57_RS09110	COG1801	Protein of unknown function DUF72
E4W57_RS09115	COG1335	isochorismatase
E4W57_RS09125	COG0494	nUDIX hydrolase
E4W57_RS09150	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4W57_RS09160	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
E4W57_RS09165	COG0739	heme binding
E4W57_RS09170	COG1560	Kdo2-lipid A biosynthetic process
E4W57_RS09180	COG1737	Transcriptional regulator
E4W57_RS09190	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E4W57_RS09195	COG0129	dihydroxy-acid dehydratase activity
E4W57_RS09200	COG0800	Aldolase
E4W57_RS09210	COG3141	response to X-ray
E4W57_RS09215	COG2979	Protein of unknown function (DUF533)
E4W57_RS09220	COG1770	oligopeptidase
E4W57_RS09225	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4W57_RS09235	COG2372	response to copper ion
E4W57_RS09240	COG1276	copper resistance
E4W57_RS09255	COG2990	Protein conserved in bacteria
E4W57_RS09280	COG3008	intermembrane lipid transfer
E4W57_RS09285	COG2995	paraquat-inducible protein a
E4W57_RS09290	COG1956	GAF domain-containing protein
E4W57_RS09310	COG2814	Major facilitator Superfamily
E4W57_RS09315	COG1414	Transcriptional regulator
E4W57_RS09345	COG0768	penicillin binding
E4W57_RS09350	COG2226	methyltransferase
E4W57_RS09365	COG3716	PTS system mannose fructose sorbose family IID component
E4W57_RS09370	COG3715	PTS system
E4W57_RS09375	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4W57_RS09375	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4W57_RS09380	COG1253	flavin adenine dinucleotide binding
E4W57_RS09385	COG2200	EAL domain
E4W57_RS09390	COG1760	l-serine dehydratase
E4W57_RS09410	COG0251	oxidation-reduction process
E4W57_RS09415	COG1199	ATP-dependent helicase activity
E4W57_RS09425	COG3065	identical protein binding
E4W57_RS09435	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E4W57_RS09445	COG2894	cell division
E4W57_RS09460	COG0179	Fumarylacetoacetate (FAA) hydrolase
E4W57_RS09490	COG2719	SpoVR family
E4W57_RS09515	COG1619	proteins homologs of microcin C7 resistance protein MccF
E4W57_RS09525	COG4774	siderophore transport
E4W57_RS09540	COG2308	Evidence 4 Homologs of previously reported genes of
E4W57_RS09580	COG0583	DNA-binding transcription factor activity
E4W57_RS09585	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4W57_RS09600	COG1882	Formate acetyltransferase
E4W57_RS09635	COG0583	DNA-binding transcription factor activity
E4W57_RS09665	COG0583	DNA-binding transcription factor activity
E4W57_RS09680	COG3122	Protein conserved in bacteria
E4W57_RS09700	COG2885	chlorophyll binding
E4W57_RS09710	COG3501	Rhs element vgr protein
E4W57_RS09715	COG1388	LysM domain
E4W57_RS09775	COG0012	GTP binding
E4W57_RS09795	COG0659	secondary active sulfate transmembrane transporter activity
E4W57_RS09825	COG2890	protein-(glutamine-N5) methyltransferase activity
E4W57_RS09845	COG0387	Pfam Sodium calcium exchanger
E4W57_RS09850	COG4572	Cation transport regulator
E4W57_RS09855	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
E4W57_RS09865	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
E4W57_RS09870	COG3707	response regulator
E4W57_RS09875	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4W57_RS09885	COG1116	anion transmembrane transporter activity
E4W57_RS09890	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4W57_RS09890	COG2146	nitrite reductase [NAD(P)H] activity
E4W57_RS09895	COG0243	molybdopterin cofactor binding
E4W57_RS09900	COG4932	domain protein
E4W57_RS09905	COG2197	response regulator
E4W57_RS09910	COG3850	Histidine kinase
E4W57_RS09915	COG2223	nitrite transmembrane transporter activity
E4W57_RS09925	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E4W57_RS09930	COG1140	nitrate reductase beta subunit
E4W57_RS09935	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E4W57_RS09940	COG2181	nitrate reductase activity
E4W57_RS09950	COG1522	sequence-specific DNA binding
E4W57_RS09980	COG0788	formyltetrahydrofolate deformylase activity
E4W57_RS09995	COG0745	RESPONSE REGULATOR receiver
E4W57_RS10000	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E4W57_RS10005	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4W57_RS10015	COG1435	thymidine kinase activity
E4W57_RS10020	COG1012	belongs to the aldehyde dehydrogenase family
E4W57_RS10020	COG1454	alcohol dehydrogenase
E4W57_RS10030	COG2095	MarC family integral membrane protein
E4W57_RS10035	COG4166	transmembrane transport
E4W57_RS10040	COG0601	transmembrane transport
E4W57_RS10045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4W57_RS10050	COG0444	Belongs to the ABC transporter superfamily
E4W57_RS10060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4W57_RS10080	COG2353	YceI-like domain
E4W57_RS10090	COG2350	Protein conserved in bacteria
E4W57_RS10100	COG3001	Fructosamine kinase
E4W57_RS10110	COG1105	Belongs to the carbohydrate kinase PfkB family
E4W57_RS10115	COG3137	Salt-induced outer membrane protein
E4W57_RS10155	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4W57_RS10155	COG0072	phenylalanine-tRNA ligase activity
E4W57_RS10175	COG0583	DNA-binding transcription factor activity
E4W57_RS10195	COG0386	Belongs to the glutathione peroxidase family
E4W57_RS10205	COG0791	NLP P60 protein
E4W57_RS10215	COG4256	Hemin uptake protein
E4W57_RS10220	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4W57_RS10235	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4W57_RS10235	COG0574	Belongs to the PEP-utilizing enzyme family
E4W57_RS10245	COG0628	permease
E4W57_RS10250	COG0277	FAD linked oxidase domain protein
E4W57_RS10250	COG0247	lactate metabolic process
E4W57_RS10255	COG2050	protein possibly involved in aromatic compounds catabolism
E4W57_RS10260	COG2261	transglycosylase associated protein
E4W57_RS10285	COG1120	ATPase activity
E4W57_RS10290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4W57_RS10300	COG0583	DNA-binding transcription factor activity
E4W57_RS10325	COG1304	FMN binding
E4W57_RS10330	COG1309	transcriptional regulator
E4W57_RS10350	COG0316	Belongs to the HesB IscA family
E4W57_RS10355	COG0719	Fe-S assembly protein
E4W57_RS10360	COG0396	ATPase activity
E4W57_RS10365	COG0719	Fe-S assembly protein
E4W57_RS10380	COG1376	ErfK ybiS ycfS ynhG family protein
E4W57_RS10410	COG1309	transcriptional regulator
E4W57_RS10420	COG2271	Major facilitator Superfamily
E4W57_RS10425	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4W57_RS10450	COG1414	Transcriptional regulator
E4W57_RS10485	COG2814	Major facilitator Superfamily
E4W57_RS10505	COG0583	DNA-binding transcription factor activity
E4W57_RS10510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4W57_RS10530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4W57_RS10535	COG1116	anion transmembrane transporter activity
E4W57_RS10540	COG4774	siderophore transport
E4W57_RS10545	COG1120	ATPase activity
E4W57_RS10550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4W57_RS10555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4W57_RS10575	COG0765	amino acid transport
E4W57_RS10580	COG1126	abc transporter atp-binding protein
E4W57_RS10620	COG3383	formate dehydrogenase (NAD+) activity
E4W57_RS10625	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E4W57_RS10635	COG1175	transmembrane transport
E4W57_RS10665	COG4133	protoheme IX ABC transporter activity
E4W57_RS10670	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4W57_RS10675	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4W57_RS10690	COG1138	Cytochrome C-type biogenesis protein
E4W57_RS10695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4W57_RS10700	COG3088	subunit of a heme lyase
E4W57_RS10700	COG4235	cytochrome complex assembly
E4W57_RS10720	COG5002	protein histidine kinase activity
E4W57_RS10720	COG3850	Histidine kinase
E4W57_RS10725	COG0745	RESPONSE REGULATOR receiver
E4W57_RS10740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4W57_RS10770	COG1028	Short-chain dehydrogenase reductase Sdr
E4W57_RS10775	COG2610	gluconate transmembrane transporter activity
E4W57_RS10780	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4W57_RS10790	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E4W57_RS10800	COG0583	DNA-binding transcription factor activity
E4W57_RS10820	COG0277	FAD linked oxidase domain protein
E4W57_RS10825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4W57_RS10850	COG0402	S-adenosylhomocysteine deaminase activity
E4W57_RS10905	COG4608	Belongs to the ABC transporter superfamily
E4W57_RS10910	COG0444	Belongs to the ABC transporter superfamily
E4W57_RS10935	COG0346	lactoylglutathione lyase activity
E4W57_RS10940	COG1349	DNA-binding transcription factor activity
E4W57_RS10995	COG0300	oxidoreductase activity
E4W57_RS11040	COG0307	riboflavin synthase, alpha
E4W57_RS11045	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E4W57_RS11050	COG2814	Major facilitator Superfamily
E4W57_RS11055	COG0583	DNA-binding transcription factor activity
E4W57_RS11070	COG2814	Major facilitator Superfamily
E4W57_RS11085	COG0791	NLP P60 protein
E4W57_RS11090	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E4W57_RS11100	COG0346	lactoylglutathione lyase activity
E4W57_RS11105	COG1902	pentaerythritol trinitrate reductase activity
E4W57_RS11110	COG1309	transcriptional regulator
E4W57_RS11115	COG3313	Fe-S protein
E4W57_RS11120	COG4989	oxidoreductase activity
E4W57_RS11125	COG2032	superoxide dismutase activity
E4W57_RS11130	COG1289	transmembrane transporter activity
E4W57_RS11135	COG1566	PFAM secretion protein HlyD family protein
E4W57_RS11150	COG3706	GGDEF domain
E4W57_RS11165	COG3895	Periplasmic Protein
E4W57_RS11180	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E4W57_RS11185	COG0625	glutathione transferase activity
E4W57_RS11195	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4W57_RS11205	COG4659	FMN binding
E4W57_RS11240	COG2723	6-phospho-beta-galactosidase activity
E4W57_RS11250	COG0673	inositol 2-dehydrogenase activity
E4W57_RS11260	COG2814	Major facilitator Superfamily
E4W57_RS11280	COG3038	cytochrome b561
E4W57_RS11300	COG0583	DNA-binding transcription factor activity
E4W57_RS11305	COG3485	protocatechuate 3,4-dioxygenase
E4W57_RS11310	COG3485	protocatechuate 3,4-dioxygenase
E4W57_RS11315	COG5383	Protein conserved in bacteria
E4W57_RS11320	COG2272	Belongs to the type-B carboxylesterase lipase family
E4W57_RS11335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4W57_RS11340	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E4W57_RS11345	COG1275	C4-dicarboxylate transporter malic acid transport protein
E4W57_RS11350	COG0500	methyltransferase
E4W57_RS11365	COG2207	Transcriptional regulator
E4W57_RS11365	COG3708	Transcriptional regulator
E4W57_RS11370	COG3135	benzoate transporter
E4W57_RS11375	COG1396	sequence-specific DNA binding
E4W57_RS11385	COG0826	peptidase U32
E4W57_RS11405	COG1294	oxidase, subunit
E4W57_RS11410	COG1271	oxidase subunit
E4W57_RS11415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4W57_RS11420	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E4W57_RS11425	COG3842	ATPase activity
E4W57_RS11430	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4W57_RS11435	COG1177	transmembrane transport
E4W57_RS11440	COG1012	belongs to the aldehyde dehydrogenase family
E4W57_RS11475	COG1012	belongs to the aldehyde dehydrogenase family
E4W57_RS11480	COG0747	negative chemotaxis
E4W57_RS11490	COG3238	Protein conserved in bacteria
E4W57_RS11495	COG1247	-acetyltransferase
E4W57_RS11505	COG2130	NADP-dependent
E4W57_RS11520	COG3691	Protein conserved in bacteria
E4W57_RS11525	COG1228	amidohydrolase
E4W57_RS11530	COG4772	TonB-dependent receptor
E4W57_RS11560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4W57_RS11565	COG1473	amidohydrolase
E4W57_RS11570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4W57_RS11585	COG0765	amino acid transport
E4W57_RS11590	COG1126	abc transporter atp-binding protein
E4W57_RS11600	COG0625	glutathione transferase activity
E4W57_RS11610	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4W57_RS11615	COG3842	ATPase activity
E4W57_RS11620	COG1840	ABC-type Fe3 transport system, periplasmic component
E4W57_RS11625	COG1178	ABC-type Fe3 transport system permease component
E4W57_RS11630	COG2162	N-hydroxyarylamine O-acetyltransferase activity
E4W57_RS11635	COG2181	nitrate reductase activity
E4W57_RS11640	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E4W57_RS11645	COG1140	nitrate reductase beta subunit
E4W57_RS11650	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E4W57_RS11670	COG1414	Transcriptional regulator
E4W57_RS11675	COG4948	Mandelate Racemase Muconate Lactonizing
E4W57_RS11680	COG4829	muconolactone delta-isomerase
E4W57_RS11685	COG3485	protocatechuate 3,4-dioxygenase
E4W57_RS11695	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E4W57_RS11720	COG0437	4 iron, 4 sulfur cluster binding
E4W57_RS11725	COG2864	formate dehydrogenase
E4W57_RS11740	COG2326	polyphosphate kinase activity
E4W57_RS11750	COG2814	Major facilitator Superfamily
E4W57_RS11760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4W57_RS11780	COG0747	negative chemotaxis
E4W57_RS11785	COG1064	alcohol dehydrogenase
E4W57_RS11800	COG0488	(ABC) transporter
E4W57_RS11845	COG1028	Short-chain dehydrogenase reductase Sdr
E4W57_RS11850	COG3729	General stress protein
E4W57_RS11860	COG3685	Protein conserved in bacteria
E4W57_RS11870	COG0366	Alpha amylase catalytic
E4W57_RS11880	COG2323	membrane
E4W57_RS11890	COG3111	PFAM Bacterial OB fold (BOF) protein
E4W57_RS11900	COG1764	response to oxidative stress
E4W57_RS11925	COG3781	membrane
E4W57_RS11930	COG0243	molybdopterin cofactor binding
E4W57_RS11935	COG0583	DNA-binding transcription factor activity
E4W57_RS11940	COG2814	Major facilitator Superfamily
E4W57_RS11945	COG1285	pathogenesis
E4W57_RS11950	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E4W57_RS11960	COG0583	DNA-binding transcription factor activity
E4W57_RS11980	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E4W57_RS11980	COG0519	Catalyzes the synthesis of GMP from XMP
E4W57_RS12020	COG0596	Alpha beta hydrolase
E4W57_RS12025	COG0745	RESPONSE REGULATOR receiver
E4W57_RS12030	COG2205	protein histidine kinase activity
E4W57_RS12045	COG0076	glutamate decarboxylase activity
E4W57_RS12050	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E4W57_RS12055	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4W57_RS12060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4W57_RS12065	COG1116	anion transmembrane transporter activity
E4W57_RS12070	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E4W57_RS12085	COG0673	inositol 2-dehydrogenase activity
E4W57_RS12095	COG1609	Transcriptional regulator
E4W57_RS12100	COG3706	GGDEF domain
E4W57_RS12105	COG0402	S-adenosylhomocysteine deaminase activity
E4W57_RS12110	COG1953	Uracil, thiamine, allantoin
E4W57_RS12145	COG1715	Restriction endonuclease
E4W57_RS12160	COG2207	Transcriptional regulator
E4W57_RS12175	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4W57_RS12255	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E4W57_RS12265	COG2070	2-Nitropropane dioxygenase
E4W57_RS12270	COG0583	DNA-binding transcription factor activity
E4W57_RS12280	COG1902	pentaerythritol trinitrate reductase activity
E4W57_RS12285	COG4529	Protein conserved in bacteria
E4W57_RS12290	COG0477	Major facilitator Superfamily
E4W57_RS12335	COG2223	nitrite transmembrane transporter activity
E4W57_RS12345	COG1609	Transcriptional regulator
E4W57_RS12350	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4W57_RS12360	COG3037	sugar-specific permease SgaT UlaA
E4W57_RS12365	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4W57_RS12375	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4W57_RS12380	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
E4W57_RS12380	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4W57_RS12380	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4W57_RS12395	COG0583	DNA-binding transcription factor activity
E4W57_RS12400	COG0583	DNA-binding transcription factor activity
E4W57_RS12405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4W57_RS12415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4W57_RS12430	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4W57_RS12440	COG1609	Transcriptional regulator
E4W57_RS12470	COG1652	LysM domain
E4W57_RS12495	COG0456	acetyltransferase
E4W57_RS12495	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
E4W57_RS12505	COG0667	Aldo Keto reductase
E4W57_RS12510	COG0667	Aldo Keto reductase
E4W57_RS12515	COG3386	PFAM SMP-30 Gluconolaconase
E4W57_RS12530	COG1349	DNA-binding transcription factor activity
E4W57_RS12545	COG1349	DNA-binding transcription factor activity
E4W57_RS12550	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4W57_RS12555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4W57_RS12560	COG0738	Major facilitator superfamily
E4W57_RS12585	COG0183	Belongs to the thiolase family
E4W57_RS12605	COG1929	Belongs to the glycerate kinase type-1 family
E4W57_RS12610	COG3835	regulator
E4W57_RS12630	COG2186	Transcriptional regulator
E4W57_RS12635	COG1263	PTS System
E4W57_RS12635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4W57_RS12645	COG2814	Major facilitator Superfamily
E4W57_RS12650	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4W57_RS12650	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4W57_RS12665	COG2819	hydrolase of the alpha beta superfamily
E4W57_RS12670	COG5001	Diguanylate cyclase
E4W57_RS12670	COG3300	MHYT domain
E4W57_RS12705	COG3188	usher protein
E4W57_RS12720	COG3550	peptidyl-serine autophosphorylation
E4W57_RS12725	COG1396	sequence-specific DNA binding
E4W57_RS12730	COG2351	hydroxyisourate hydrolase activity
E4W57_RS12735	COG3195	allantoin biosynthetic process
E4W57_RS12735	COG3648	Uricase
E4W57_RS12740	COG2233	PERMEase
E4W57_RS12770	COG2207	Transcriptional regulator
E4W57_RS12785	COG4628	conserved protein (DUF2132)
E4W57_RS12805	COG2011	ABC-type metal ion transport system permease component
E4W57_RS12810	COG2070	2-Nitropropane dioxygenase
E4W57_RS12820	COG0477	Major facilitator Superfamily
E4W57_RS12870	COG2199	diguanylate cyclase activity
E4W57_RS12885	COG1012	belongs to the aldehyde dehydrogenase family
E4W57_RS12890	COG0583	DNA-binding transcription factor activity
E4W57_RS12900	COG0039	L-malate dehydrogenase activity
E4W57_RS12905	COG1349	DNA-binding transcription factor activity
E4W57_RS12910	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E4W57_RS12915	COG3395	kinase activity
E4W57_RS12925	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4W57_RS12930	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4W57_RS12935	COG2271	Major facilitator Superfamily
E4W57_RS12965	COG4977	sequence-specific DNA binding
E4W57_RS12975	COG0697	spore germination
E4W57_RS12980	COG2814	Major facilitator Superfamily
E4W57_RS13015	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E4W57_RS13050	COG2223	nitrite transmembrane transporter activity
E4W57_RS13055	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E4W57_RS13070	COG1349	DNA-binding transcription factor activity
E4W57_RS13080	COG3395	kinase activity
E4W57_RS13085	COG0235	Class ii aldolase
E4W57_RS13090	COG3622	Belongs to the hyi family
E4W57_RS13095	COG2610	gluconate transmembrane transporter activity
E4W57_RS13100	COG2207	Transcriptional regulator
E4W57_RS13100	COG3708	Transcriptional regulator
E4W57_RS13115	COG2200	EAL domain
E4W57_RS13120	COG1546	Belongs to the CinA family
E4W57_RS13125	COG0071	Belongs to the small heat shock protein (HSP20) family
E4W57_RS13155	COG2135	peptidase activity
E4W57_RS13160	COG2207	Transcriptional regulator
E4W57_RS13175	COG4221	oxidoreductase activity
E4W57_RS13180	COG1802	Transcriptional regulator
E4W57_RS13185	COG0589	response to stress
E4W57_RS13190	COG0246	Mannitol dehydrogenase
E4W57_RS13195	COG2271	Major facilitator Superfamily
E4W57_RS13210	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4W57_RS13225	COG0243	molybdopterin cofactor binding
E4W57_RS13230	COG0437	4 iron, 4 sulfur cluster binding
E4W57_RS13235	COG3302	dmso reductase anchor subunit
E4W57_RS13250	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E4W57_RS13255	COG1940	carbohydrate kinase activity
E4W57_RS13260	COG0583	DNA-binding transcription factor activity
E4W57_RS13265	COG2814	Major facilitator Superfamily
E4W57_RS13270	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
E4W57_RS13280	COG3591	Belongs to the peptidase S1B family
E4W57_RS13300	COG0628	permease
E4W57_RS13330	COG0679	Auxin Efflux Carrier
E4W57_RS13340	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E4W57_RS13365	COG3290	protein histidine kinase activity
E4W57_RS13370	COG4565	transcriptional regulatory protein
E4W57_RS13390	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E4W57_RS13390	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E4W57_RS13400	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4W57_RS13405	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E4W57_RS13415	COG0183	Belongs to the thiolase family
E4W57_RS13420	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E4W57_RS13430	COG1414	Transcriptional regulator
E4W57_RS13435	COG2840	Smr protein MutS2
E4W57_RS13440	COG0583	DNA-binding transcription factor activity
E4W57_RS13450	COG1473	amidohydrolase
E4W57_RS13455	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E4W57_RS13470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4W57_RS13485	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E4W57_RS13490	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E4W57_RS13505	COG0531	amino acid
E4W57_RS13515	COG3136	membrane protein required for alginate biosynthesis
E4W57_RS13520	COG0745	RESPONSE REGULATOR receiver
E4W57_RS13530	COG2205	protein histidine kinase activity
E4W57_RS13540	COG0114	fumarate hydratase activity
E4W57_RS13545	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E4W57_RS13545	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E4W57_RS13550	COG1482	cell wall glycoprotein biosynthetic process
E4W57_RS13555	COG5339	Protein conserved in bacteria
E4W57_RS13560	COG1609	Transcriptional regulator
E4W57_RS13565	COG1263	PTS System
E4W57_RS13565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4W57_RS13570	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4W57_RS13595	COG2391	methyltransferase activity
E4W57_RS13600	COG0425	Belongs to the sulfur carrier protein TusA family
E4W57_RS13605	COG5562	phage envelope protein
E4W57_RS13610	COG0401	homolog of Blt101
E4W57_RS13615	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4W57_RS13620	COG1012	belongs to the aldehyde dehydrogenase family
E4W57_RS13630	COG1434	Gram-negative-bacterium-type cell wall biogenesis
E4W57_RS13635	COG0477	Major facilitator Superfamily
E4W57_RS13640	COG1113	amino acid transport
E4W57_RS13645	COG2988	succinylglutamate desuccinylase activity
E4W57_RS13650	COG3724	N-succinylarginine dihydrolase activity
E4W57_RS13655	COG1012	belongs to the aldehyde dehydrogenase family
E4W57_RS13660	COG3138	arginine N-succinyltransferase
E4W57_RS13665	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E4W57_RS13675	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E4W57_RS13680	COG0667	Aldo Keto reductase
E4W57_RS13685	COG0583	DNA-binding transcription factor activity
E4W57_RS13710	COG4122	O-methyltransferase activity
E4W57_RS13715	COG1643	Atp-dependent helicase
E4W57_RS13730	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E4W57_RS13735	COG3327	negative regulation of DNA-templated transcription, initiation
E4W57_RS13740	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
E4W57_RS13745	COG0183	Belongs to the thiolase family
E4W57_RS13750	COG2050	protein possibly involved in aromatic compounds catabolism
E4W57_RS13755	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4W57_RS13760	COG1024	Enoyl-CoA hydratase
E4W57_RS13765	COG1024	Enoyl-CoA hydratase
E4W57_RS13770	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4W57_RS13775	COG2151	metal-sulfur cluster biosynthetic enzyme
E4W57_RS13780	COG3396	Phenylacetate-CoA oxygenase
E4W57_RS13785	COG3460	Phenylacetate-CoA oxygenase
E4W57_RS13790	COG3396	Phenylacetate-CoA oxygenase
E4W57_RS13795	COG2030	dehydratase
E4W57_RS13795	COG1012	belongs to the aldehyde dehydrogenase family
E4W57_RS13815	COG1012	belongs to the aldehyde dehydrogenase family
E4W57_RS13820	COG2207	Transcriptional regulator
E4W57_RS13825	COG3784	Protein of unknown function (DUF1318)
E4W57_RS13835	COG2911	Protein conserved in bacteria
E4W57_RS13840	COG0586	Pfam SNARE associated Golgi protein
E4W57_RS13845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4W57_RS13850	COG3187	Heat shock protein
E4W57_RS13855	COG3042	response to heat
E4W57_RS13860	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4W57_RS13860	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4W57_RS13860	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4W57_RS13860	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4W57_RS13865	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4W57_RS13875	COG0589	response to stress
E4W57_RS13885	COG0513	Belongs to the DEAD box helicase family
E4W57_RS13895	COG1349	DNA-binding transcription factor activity
E4W57_RS13900	COG0673	inositol 2-dehydrogenase activity
E4W57_RS13915	COG1113	amino acid transport
E4W57_RS13920	COG1522	sequence-specific DNA binding
E4W57_RS13930	COG1448	Aminotransferase
E4W57_RS13935	COG2011	ABC-type metal ion transport system permease component
E4W57_RS13950	COG0436	Aminotransferase
E4W57_RS13955	COG0604	alcohol dehydrogenase
E4W57_RS13985	COG0583	DNA-binding transcription factor activity
E4W57_RS14005	COG1028	Short-chain dehydrogenase reductase Sdr
E4W57_RS14010	COG1309	transcriptional regulator
E4W57_RS14015	COG1028	Short-chain dehydrogenase reductase Sdr
E4W57_RS14090	COG2885	chlorophyll binding
E4W57_RS14115	COG0693	protein deglycase activity
E4W57_RS14120	COG1078	dGTPase activity
E4W57_RS14125	COG1028	Short-chain dehydrogenase reductase Sdr
E4W57_RS14130	COG0583	DNA-binding transcription factor activity
E4W57_RS14145	COG0656	L-ascorbic acid biosynthetic process
E4W57_RS14175	COG4166	transmembrane transport
E4W57_RS14185	COG2866	Carboxypeptidase
E4W57_RS14190	COG4948	Mandelate Racemase Muconate Lactonizing
E4W57_RS14195	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
E4W57_RS14200	COG3180	Ammonia monooxygenase
E4W57_RS14210	COG1486	melibiose metabolic process
E4W57_RS14215	COG0583	DNA-binding transcription factor activity
E4W57_RS14225	COG3106	COG3106 Predicted ATPase
E4W57_RS14235	COG1983	PspC domain protein
E4W57_RS14245	COG1842	Phage shock protein A
E4W57_RS14250	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E4W57_RS14260	COG1473	amidohydrolase
E4W57_RS14275	COG0702	epimerase
E4W57_RS14290	COG4171	peptide transport system, permease
E4W57_RS14305	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E4W57_RS14315	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4W57_RS14320	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4W57_RS14320	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4W57_RS14335	COG1349	DNA-binding transcription factor activity
E4W57_RS14345	COG0023	Translation Initiation Factor
E4W57_RS14355	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E4W57_RS14360	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
E4W57_RS14365	COG0671	phosphoesterase, PA-phosphatase related
E4W57_RS14375	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E4W57_RS14400	COG0616	signal peptide processing
E4W57_RS14410	COG1028	Short-chain dehydrogenase reductase Sdr
E4W57_RS14415	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
E4W57_RS14425	COG0583	DNA-binding transcription factor activity
E4W57_RS14435	COG0009	L-threonylcarbamoyladenylate synthase
E4W57_RS14445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E4W57_RS14450	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E4W57_RS14450	COG0512	Glutamine amidotransferase of anthranilate synthase
E4W57_RS14455	COG0134	indole-3-glycerol-phosphate synthase activity
E4W57_RS14455	COG0135	phosphoribosylanthranilate isomerase activity
E4W57_RS14490	COG4774	siderophore transport
E4W57_RS14500	COG3047	cAMP biosynthetic process
E4W57_RS14505	COG0727	PFAM Uncharacterised protein family (UPF0153)
E4W57_RS14535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4W57_RS14540	COG1028	Short-chain dehydrogenase reductase Sdr
E4W57_RS14545	COG1988	membrane-bound metal-dependent
E4W57_RS14560	COG0753	catalase activity
E4W57_RS14570	COG1486	melibiose metabolic process
E4W57_RS14575	COG2169	Transcriptional regulator
E4W57_RS14575	COG1917	Cupin 2, conserved barrel domain protein
E4W57_RS14580	COG1447	Phosphotransferase system cellobiose-specific component IIA
E4W57_RS14585	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4W57_RS14595	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4W57_RS14600	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4W57_RS14610	COG0322	excinuclease ABC activity
E4W57_RS14615	COG3678	ATP-independent chaperone mediated protein folding
E4W57_RS14625	COG3724	N-succinylarginine dihydrolase activity
E4W57_RS14635	COG3138	arginine N-succinyltransferase
E4W57_RS14645	COG0708	Exodeoxyribonuclease III
E4W57_RS14650	COG0398	Pfam SNARE associated Golgi protein
E4W57_RS14655	COG0398	Pfam SNARE associated Golgi protein
E4W57_RS14660	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4W57_RS14665	COG4134	Bacterial extracellular solute-binding protein
E4W57_RS14670	COG4135	transport system, permease component
E4W57_RS14675	COG4136	ATPase activity
E4W57_RS14680	COG2897	thiosulfate sulfurtransferase activity
E4W57_RS14685	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4W57_RS14690	COG0494	nUDIX hydrolase
E4W57_RS14695	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E4W57_RS14700	COG3321	synthase
E4W57_RS14700	COG1028	Short-chain dehydrogenase reductase Sdr
E4W57_RS14700	COG0604	alcohol dehydrogenase
E4W57_RS14705	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4W57_RS14710	COG0709	Synthesizes selenophosphate from selenide and ATP
E4W57_RS14720	COG0778	Nitroreductase
E4W57_RS14725	COG0616	signal peptide processing
E4W57_RS14730	COG0252	asparaginase activity
E4W57_RS14735	COG1335	isochorismatase
E4W57_RS14750	COG3139	Protein of unknown function (DUF1315)
E4W57_RS14770	COG0656	L-ascorbic acid biosynthetic process
E4W57_RS14775	COG3713	MltA-interacting MipA family protein
E4W57_RS14780	COG2766	serine protein kinase
E4W57_RS14820	COG1028	Short-chain dehydrogenase reductase Sdr
E4W57_RS14825	COG0583	DNA-binding transcription factor activity
E4W57_RS14830	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4W57_RS14835	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E4W57_RS14845	COG0859	PFAM glycosyl transferase family 9
E4W57_RS14850	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E4W57_RS14860	COG2207	Transcriptional regulator
E4W57_RS14865	COG2807	transmembrane transport
E4W57_RS14870	COG0504	CTP synthase activity
E4W57_RS14875	COG1683	Conserved Protein
E4W57_RS14880	COG3189	MarR family transcriptional regulator
E4W57_RS14885	COG3042	response to heat
E4W57_RS14890	COG2199	diguanylate cyclase activity
E4W57_RS14890	COG2203	Gaf domain
E4W57_RS14910	COG3182	Iron-regulated membrane protein
E4W57_RS14920	COG1560	Kdo2-lipid A biosynthetic process
E4W57_RS14930	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E4W57_RS14935	COG3706	GGDEF domain
E4W57_RS14940	COG0583	DNA-binding transcription factor activity
E4W57_RS14945	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E4W57_RS14975	COG1294	oxidase, subunit
E4W57_RS14980	COG1271	oxidase subunit
E4W57_RS14985	COG3546	catalase activity
E4W57_RS14990	COG3685	Protein conserved in bacteria
E4W57_RS14995	COG3685	Protein conserved in bacteria
E4W57_RS15000	COG3729	General stress protein
E4W57_RS15010	COG1063	alcohol dehydrogenase
E4W57_RS15015	COG3813	Protein conserved in bacteria
E4W57_RS15035	COG0640	Transcriptional regulator
E4W57_RS15040	COG0538	isocitrate dehydrogenase activity
E4W57_RS15045	COG3300	MHYT domain
E4W57_RS15045	COG5001	Diguanylate cyclase
E4W57_RS15050	COG3706	GGDEF domain
E4W57_RS15135	COG0616	signal peptide processing
E4W57_RS15145	COG4626	Terminase
E4W57_RS15145	COG1802	Transcriptional regulator
E4W57_RS15180	COG3772	lysozyme
E4W57_RS15205	COG1403	HNH endonuclease
E4W57_RS15225	COG2378	regulation of single-species biofilm formation
E4W57_RS15230	COG1028	Short-chain dehydrogenase reductase Sdr
E4W57_RS15280	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4W57_RS15290	COG0582	viral genome integration into host DNA
E4W57_RS15295	COG0538	isocitrate dehydrogenase activity
E4W57_RS15300	COG1187	pseudouridine synthase activity
E4W57_RS15320	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4W57_RS15340	COG2205	protein histidine kinase activity
E4W57_RS15345	COG2850	peptidyl-arginine hydroxylation
E4W57_RS15365	COG1177	transmembrane transport
E4W57_RS15380	COG0318	PFAM AMP-dependent synthetase and ligase
E4W57_RS15385	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4W57_RS15390	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4W57_RS15395	COG0698	ribose 5-phosphate isomerase
E4W57_RS15410	COG3395	kinase activity
E4W57_RS15425	COG2390	Transcriptional regulator
E4W57_RS15435	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E4W57_RS15445	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4W57_RS15455	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4W57_RS15465	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E4W57_RS15470	COG1388	LysM domain
E4W57_RS15470	COG1376	ErfK ybiS ycfS ynhG family protein
E4W57_RS15485	COG1309	transcriptional regulator
E4W57_RS15500	COG3134	Outer membrane lipoprotein
E4W57_RS15505	COG1252	NADH dehydrogenase
E4W57_RS15530	COG5633	Lipoprotein
E4W57_RS15535	COG0537	adenosine 5'-monophosphoramidase activity
E4W57_RS15545	COG0084	hydrolase, TatD family'
E4W57_RS15550	COG0470	DNA polymerase III
E4W57_RS15560	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4W57_RS15565	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4W57_RS15570	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4W57_RS15585	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E4W57_RS15605	COG1399	metal-binding, possibly nucleic acid-binding protein
E4W57_RS15625	COG1530	ribonuclease E activity
E4W57_RS15630	COG0583	DNA-binding transcription factor activity
E4W57_RS15635	COG2814	Major facilitator Superfamily
E4W57_RS15655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4W57_RS15700	COG1560	Kdo2-lipid A biosynthetic process
E4W57_RS15715	COG5645	(Lipo)protein
E4W57_RS15750	COG3381	protein complex oligomerization
E4W57_RS15770	COG0583	DNA-binding transcription factor activity
E4W57_RS15780	COG1335	isochorismatase
E4W57_RS15855	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4W57_RS15860	COG1702	phosphate starvation-inducible protein PhoH
E4W57_RS15880	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4W57_RS15890	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4W57_RS15905	COG1309	transcriptional regulator
E4W57_RS15940	COG2233	PERMEase
E4W57_RS15950	COG3729	General stress protein
E4W57_RS15980	COG1028	Short-chain dehydrogenase reductase Sdr
E4W57_RS15995	COG0531	amino acid
E4W57_RS16000	COG0174	glutamine synthetase
E4W57_RS16005	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4W57_RS16010	COG1396	sequence-specific DNA binding
E4W57_RS16010	COG1917	Cupin 2, conserved barrel domain protein
E4W57_RS16015	COG1012	belongs to the aldehyde dehydrogenase family
E4W57_RS16020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4W57_RS16025	COG0583	DNA-binding transcription factor activity
E4W57_RS16030	COG0473	3-isopropylmalate dehydrogenase activity
E4W57_RS16035	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4W57_RS16040	COG4638	Rieske (2fe-2S)
E4W57_RS16045	COG1012	belongs to the aldehyde dehydrogenase family
E4W57_RS16050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4W57_RS16075	COG0670	Belongs to the BI1 family
E4W57_RS16090	COG2207	Transcriptional regulator
E4W57_RS16095	COG1881	PFAM PEBP family protein
E4W57_RS16120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4W57_RS16125	COG2274	protein secretion by the type I secretion system
E4W57_RS16140	COG1832	CoA-binding protein
E4W57_RS16150	COG0210	DNA helicase
E4W57_RS16155	COG3304	Inner membrane component domain
E4W57_RS16160	COG1289	transmembrane transporter activity
E4W57_RS16165	COG3070	regulator of competence-specific genes
E4W57_RS16185	COG1067	ATP-dependent peptidase activity
E4W57_RS16195	COG3130	regulation of translation
E4W57_RS16200	COG3009	Protein conserved in bacteria
E4W57_RS16205	COG3008	intermembrane lipid transfer
E4W57_RS16205	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E4W57_RS16210	COG2995	paraquat-inducible protein a
E4W57_RS16215	COG0488	(ABC) transporter
E4W57_RS16225	COG3217	Mosc domain protein beta barrel domain protein
E4W57_RS16225	COG0633	Ferredoxin
E4W57_RS16240	COG0431	NADPH-dependent FMN reductase
E4W57_RS16245	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4W57_RS16250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4W57_RS16255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4W57_RS16265	COG0308	aminopeptidase N
E4W57_RS16275	COG1473	amidohydrolase
E4W57_RS16285	COG0814	amino acid
E4W57_RS16305	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4W57_RS16310	COG1448	Aminotransferase
E4W57_RS16315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4W57_RS16320	COG3108	Peptidase M15
E4W57_RS16325	COG2989	Protein conserved in bacteria
E4W57_RS16335	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
E4W57_RS16345	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4W57_RS16350	COG1434	Gram-negative-bacterium-type cell wall biogenesis
E4W57_RS16355	COG3173	Aminoglycoside phosphotransferase
E4W57_RS16370	COG3214	Protein conserved in bacteria
E4W57_RS16395	COG0539	negative regulation of cytoplasmic translation
E4W57_RS16415	COG2323	membrane
E4W57_RS16420	COG1944	ATP diphosphatase activity
E4W57_RS16425	COG2116	formate transmembrane transporter activity
E4W57_RS16430	COG1882	Formate acetyltransferase
E4W57_RS16435	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4W57_RS16440	COG0477	Major facilitator Superfamily
E4W57_RS16445	COG3302	dmso reductase anchor subunit
E4W57_RS16450	COG0437	4 iron, 4 sulfur cluster binding
E4W57_RS16455	COG0243	molybdopterin cofactor binding
E4W57_RS16465	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E4W57_RS16475	COG1178	ABC-type Fe3 transport system permease component
E4W57_RS16475	COG1674	ftsk spoiiie
E4W57_RS16485	COG0492	ferredoxin-NADP+ reductase activity
E4W57_RS16490	COG4988	ABC transporter
E4W57_RS16495	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E4W57_RS16510	COG0542	response to heat
E4W57_RS16520	COG1278	Cold shock
E4W57_RS16530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4W57_RS16535	COG3593	DNA synthesis involved in DNA repair
E4W57_RS16545	COG2431	L-lysine efflux transmembrane transporter activity
E4W57_RS16555	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4W57_RS16565	COG0028	Belongs to the TPP enzyme family
E4W57_RS16570	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
E4W57_RS16575	COG0702	epimerase
E4W57_RS16580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4W57_RS16585	COG3023	N-Acetylmuramoyl-L-alanine amidase
E4W57_RS16590	COG5001	Diguanylate cyclase
E4W57_RS16590	COG4251	negative regulation of phosphorylation
E4W57_RS16590	COG3706	GGDEF domain
E4W57_RS16590	COG2203	Gaf domain
E4W57_RS16600	COG1126	abc transporter atp-binding protein
E4W57_RS16605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4W57_RS16610	COG4215	(ABC) transporter
E4W57_RS16615	COG4160	amino acid transport
E4W57_RS16620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4W57_RS16625	COG5002	protein histidine kinase activity
E4W57_RS16630	COG0745	RESPONSE REGULATOR receiver
E4W57_RS16645	COG1177	transmembrane transport
E4W57_RS16650	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4W57_RS16655	COG3842	ATPase activity
E4W57_RS16660	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E4W57_RS16675	COG0778	Nitroreductase
E4W57_RS16740	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E4W57_RS16850	COG4695	Portal protein
E4W57_RS16885	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4W57_RS16925	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E4W57_RS16930	COG3226	Transcriptional regulator
E4W57_RS16935	COG0738	Major facilitator superfamily
E4W57_RS16940	COG0561	phosphatase activity
E4W57_RS16945	COG2814	Major facilitator Superfamily
E4W57_RS16950	COG0671	phosphoesterase, PA-phosphatase related
E4W57_RS16955	COG1349	DNA-binding transcription factor activity
E4W57_RS16960	COG1686	Belongs to the peptidase S11 family
E4W57_RS16970	COG0625	glutathione transferase activity
E4W57_RS16975	COG2133	pyrroloquinoline quinone binding
E4W57_RS16985	COG2211	Major facilitator Superfamily
E4W57_RS17005	COG0747	negative chemotaxis
E4W57_RS17020	COG0303	'Molybdopterin
E4W57_RS17025	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4W57_RS17030	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4W57_RS17035	COG1882	Formate acetyltransferase
E4W57_RS17040	COG0561	phosphatase activity
E4W57_RS17050	COG1609	Transcriptional regulator
E4W57_RS17055	COG2271	Major facilitator Superfamily
E4W57_RS17065	COG0488	(ABC) transporter
E4W57_RS17070	COG2365	Tyrosine phosphatase family
E4W57_RS17075	COG1376	ErfK ybiS ycfS ynhG family protein
E4W57_RS17080	COG2188	Transcriptional regulator
E4W57_RS17085	COG2723	6-phospho-beta-galactosidase activity
E4W57_RS17090	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E4W57_RS17105	COG2194	sulfuric ester hydrolase activity
E4W57_RS17110	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E4W57_RS17125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4W57_RS17130	COG0765	amino acid transport
E4W57_RS17135	COG1126	abc transporter atp-binding protein
E4W57_RS17140	COG0668	transmembrane transport
E4W57_RS17150	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4W57_RS17160	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4W57_RS17170	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E4W57_RS17175	COG1199	ATP-dependent helicase activity
E4W57_RS17180	COG0513	Belongs to the DEAD box helicase family
E4W57_RS17185	COG3958	Transketolase
E4W57_RS17190	COG3959	Transketolase, thiamine diphosphate binding domain
E4W57_RS17195	COG1028	Short-chain dehydrogenase reductase Sdr
E4W57_RS17200	COG2271	Major facilitator Superfamily
E4W57_RS17210	COG0583	DNA-binding transcription factor activity
E4W57_RS17215	COG1309	transcriptional regulator
E4W57_RS17220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4W57_RS17225	COG1131	(ABC) transporter
E4W57_RS17230	COG0842	Transport permease protein
E4W57_RS17235	COG0842	Transport permease protein
E4W57_RS17245	COG3568	Endonuclease Exonuclease Phosphatase
E4W57_RS17250	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4W57_RS17255	COG0392	lysyltransferase activity
E4W57_RS17260	COG0670	Belongs to the BI1 family
E4W57_RS17265	COG0314	molybdopterin synthase activity
E4W57_RS17270	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E4W57_RS17280	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4W57_RS17300	COG0745	RESPONSE REGULATOR receiver
E4W57_RS17305	COG0642	Histidine kinase
E4W57_RS17330	COG2226	methyltransferase
E4W57_RS17345	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E4W57_RS17350	COG1881	PFAM PEBP family protein
E4W57_RS17390	COG4677	pectinesterase activity
E4W57_RS17400	COG0589	response to stress
E4W57_RS17405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4W57_RS17440	COG0789	Transcriptional regulator
E4W57_RS17445	COG2200	EAL domain
E4W57_RS17470	COG0561	phosphatase activity
E4W57_RS17480	COG4149	molybdate abc transporter
E4W57_RS17485	COG0725	ABC transporter, periplasmic molybdate-binding protein
E4W57_RS17495	COG3585	molybdate ion transport
E4W57_RS17495	COG2005	Transcriptional regulator
E4W57_RS17500	COG1119	ATPase activity
E4W57_RS17510	COG1085	galactose-1-phosphate uridylyltransferase
E4W57_RS17520	COG2017	converts alpha-aldose to the beta-anomer
E4W57_RS17530	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4W57_RS17545	COG3201	nicotinamide mononucleotide transporter
E4W57_RS17550	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E4W57_RS17600	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E4W57_RS17605	COG2885	chlorophyll binding
E4W57_RS17615	COG3064	Membrane
E4W57_RS17620	COG0848	biopolymer transport protein
E4W57_RS17625	COG0811	peptide transport
E4W57_RS17630	COG0824	Thioesterase
E4W57_RS17635	COG3790	cyd operon protein YbgE
E4W57_RS17640	COG4890	Cyd operon protein YbgT
E4W57_RS17645	COG1294	oxidase, subunit
E4W57_RS17650	COG1271	oxidase subunit
E4W57_RS17655	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E4W57_RS17665	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4W57_RS17670	COG0567	Dehydrogenase, E1 component
E4W57_RS17675	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E4W57_RS17680	COG1053	succinate dehydrogenase
E4W57_RS17685	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E4W57_RS17690	COG2009	succinate dehydrogenase
E4W57_RS17725	COG1984	allophanate hydrolase subunit 2
E4W57_RS17730	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E4W57_RS17745	COG0415	Belongs to the DNA photolyase family
E4W57_RS17775	COG2205	protein histidine kinase activity
E4W57_RS17780	COG0745	RESPONSE REGULATOR receiver
E4W57_RS17790	COG0033	Phosphoglucomutase
E4W57_RS17800	COG0596	Alpha beta hydrolase
E4W57_RS17815	COG0735	belongs to the Fur family
E4W57_RS17855	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4W57_RS17860	COG1846	Transcriptional regulator
E4W57_RS17860	COG1940	carbohydrate kinase activity
E4W57_RS17865	COG0647	UMP catabolic process
E4W57_RS17870	COG0367	asparagine synthase
E4W57_RS17910	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4W57_RS17920	COG1702	phosphate starvation-inducible protein PhoH
E4W57_RS17945	COG0765	amino acid transport
E4W57_RS17950	COG0765	amino acid transport
E4W57_RS17955	COG1126	abc transporter atp-binding protein
E4W57_RS17970	COG2888	peptidyl-tyrosine sulfation
E4W57_RS17985	COG1466	dna polymerase III delta subunit
E4W57_RS18000	COG0799	negative regulation of ribosome biogenesis
E4W57_RS18010	COG0768	penicillin binding
E4W57_RS18015	COG0772	Belongs to the SEDS family
E4W57_RS18020	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4W57_RS18025	COG1686	Belongs to the peptidase S11 family
E4W57_RS18040	COG0583	DNA-binding transcription factor activity
E4W57_RS18055	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4W57_RS18075	COG3069	C4-dicarboxylate transmembrane transporter activity
E4W57_RS18080	COG3719	Belongs to the RNase T2 family
E4W57_RS18085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4W57_RS18105	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4W57_RS18110	COG0583	DNA-binding transcription factor activity
E4W57_RS18115	COG3969	phosphoadenosine phosphosulfate
E4W57_RS18120	COG1475	DNA binding
E4W57_RS18125	COG0436	Aminotransferase
E4W57_RS18150	COG1129	ABC transporter
E4W57_RS18155	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4W57_RS18160	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4W57_RS18170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4W57_RS18185	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E4W57_RS18195	COG0402	S-adenosylhomocysteine deaminase activity
E4W57_RS18205	COG0483	inositol monophosphate 1-phosphatase activity
E4W57_RS18210	COG2271	Major facilitator Superfamily
E4W57_RS18240	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4W57_RS18245	COG1129	ABC transporter
E4W57_RS18250	COG0371	Dehydrogenase
E4W57_RS18255	COG1028	Short-chain dehydrogenase reductase Sdr
E4W57_RS18270	COG2879	small protein
E4W57_RS18275	COG1966	Carbon starvation protein
E4W57_RS18285	COG1028	Short-chain dehydrogenase reductase Sdr
E4W57_RS18290	COG3433	isochorismatase activity
E4W57_RS18290	COG1535	isochorismatase
E4W57_RS18295	COG1021	2,3-dihydroxybenzoate-AMP ligase
E4W57_RS18300	COG1169	isochorismate synthase
E4W57_RS18305	COG4592	Periplasmic binding protein
E4W57_RS18315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4W57_RS18320	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4W57_RS18325	COG1120	ATPase activity
E4W57_RS18330	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
E4W57_RS18330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4W57_RS18335	COG3251	PFAM MbtH domain protein
E4W57_RS18340	COG2382	esterase
E4W57_RS18345	COG4771	TonB-dependent receptor
E4W57_RS18355	COG1879	ABC-type sugar transport system periplasmic component
E4W57_RS18365	COG1129	ABC transporter
E4W57_RS18370	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4W57_RS18375	COG5464	transposase or invertase
E4W57_RS18380	COG2390	Transcriptional regulator
E4W57_RS18385	COG3959	Transketolase, thiamine diphosphate binding domain
E4W57_RS18390	COG3958	Transketolase
E4W57_RS18400	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4W57_RS18410	COG0583	DNA-binding transcription factor activity
E4W57_RS18415	COG0668	transmembrane transport
E4W57_RS18425	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4W57_RS18450	COG0747	negative chemotaxis
E4W57_RS18455	COG0601	transmembrane transport
E4W57_RS18460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4W57_RS18465	COG0444	Belongs to the ABC transporter superfamily
E4W57_RS18470	COG4608	Belongs to the ABC transporter superfamily
E4W57_RS18485	COG0656	L-ascorbic acid biosynthetic process
E4W57_RS18505	COG4221	oxidoreductase activity
E4W57_RS18515	COG4215	(ABC) transporter
E4W57_RS18520	COG0765	amino acid transport
E4W57_RS18525	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E4W57_RS18540	COG0697	spore germination
E4W57_RS18555	COG4608	Belongs to the ABC transporter superfamily
E4W57_RS18560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4W57_RS18570	COG4166	transmembrane transport
E4W57_RS18580	COG3698	Phosphodiester glycosidase
E4W57_RS18620	COG2315	Protein conserved in bacteria
E4W57_RS18625	COG0778	Nitroreductase
E4W57_RS18635	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4W57_RS18645	COG3716	PTS system mannose fructose sorbose family IID component
E4W57_RS18650	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E4W57_RS18655	COG2222	sugar isomerase
E4W57_RS18660	COG3933	PFAM sigma-54 factor interaction domain-containing protein
E4W57_RS18660	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E4W57_RS18675	COG0477	Major facilitator Superfamily
E4W57_RS18680	COG0668	transmembrane transport
E4W57_RS18695	COG0673	inositol 2-dehydrogenase activity
E4W57_RS18705	COG2211	Major facilitator Superfamily
E4W57_RS18710	COG1113	amino acid transport
E4W57_RS18725	COG1012	belongs to the aldehyde dehydrogenase family
E4W57_RS18730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4W57_RS18740	COG0531	amino acid
E4W57_RS18755	COG4680	protein conserved in bacteria
E4W57_RS18795	COG0667	Aldo Keto reductase
E4W57_RS18800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4W57_RS18805	COG1473	amidohydrolase
E4W57_RS18835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4W57_RS18840	COG1120	ATPase activity
E4W57_RS18845	COG1566	PFAM secretion protein HlyD family protein
E4W57_RS18890	COG4211	Belongs to the binding-protein-dependent transport system permease family
E4W57_RS18895	COG1129	ABC transporter
E4W57_RS18940	COG3104	oligopeptide transport
E4W57_RS18945	COG1982	Orn Lys Arg decarboxylase major
E4W57_RS18950	COG0531	amino acid
E4W57_RS18955	COG3710	Transcriptional regulator
E4W57_RS18965	COG1560	Kdo2-lipid A biosynthetic process
E4W57_RS19010	COG2501	S4 domain
E4W57_RS19020	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4W57_RS19035	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E4W57_RS19040	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E4W57_RS19060	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E4W57_RS19065	COG4181	ATPase activity
E4W57_RS19070	COG2755	lipolytic protein G-D-S-L family
E4W57_RS19075	COG0300	oxidoreductase activity
E4W57_RS19080	COG3118	belongs to the thioredoxin family
E4W57_RS19085	COG0390	transport system, permease component
E4W57_RS19090	COG4619	ABC transporter
E4W57_RS19095	COG0330	HflC and HflK could
E4W57_RS19100	COG1585	Membrane protein implicated in regulation of membrane protease activity
E4W57_RS19115	COG3735	TraB family
E4W57_RS19120	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E4W57_RS19130	COG2223	nitrite transmembrane transporter activity
E4W57_RS19135	COG4651	solute:proton antiporter activity
E4W57_RS19135	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4W57_RS19140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4W57_RS19180	COG2832	Protein of unknown function (DUF454)
E4W57_RS19185	COG3923	Primosomal replication protein n
E4W57_RS19200	COG1196	nuclear chromosome segregation
E4W57_RS19200	COG3264	Mechanosensitive ion channel
E4W57_RS19205	COG1309	transcriptional regulator
E4W57_RS19210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4W57_RS19215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4W57_RS19230	COG0110	maltose O-acetyltransferase activity
E4W57_RS19280	COG1874	Beta-galactosidase
E4W57_RS19285	COG3867	Arabinogalactan endo-beta-1,4-galactanase
E4W57_RS19290	COG3833	ABC-type maltose transport systems, permease component
E4W57_RS19295	COG1175	transmembrane transport
E4W57_RS19300	COG2182	Extracellular solute-binding protein
E4W57_RS19310	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E4W57_RS19325	COG2364	Membrane
E4W57_RS19355	COG3695	enzyme binding
E4W57_RS19360	COG3126	Type III secretion system lipoprotein chaperone (YscW)
E4W57_RS19365	COG1946	Acyl-CoA thioesterase
E4W57_RS19370	COG0004	ammonium transporteR
E4W57_RS19375	COG0347	Belongs to the P(II) protein family
E4W57_RS19380	COG1132	(ABC) transporter
E4W57_RS19385	COG1132	(ABC) transporter
E4W57_RS19390	COG1522	sequence-specific DNA binding
E4W57_RS19405	COG4533	DNA binding
E4W57_RS19415	COG0824	Thioesterase
E4W57_RS19420	COG1555	photosystem II stabilization
E4W57_RS19425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4W57_RS19430	COG0776	regulation of translation
E4W57_RS19435	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4W57_RS19455	COG0271	Belongs to the BolA IbaG family
E4W57_RS19460	COG3056	Lipoprotein
E4W57_RS19465	COG2223	nitrite transmembrane transporter activity
E4W57_RS19470	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E4W57_RS19475	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4W57_RS19480	COG1845	cytochrome c oxidase, subunit III
E4W57_RS19485	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E4W57_RS19500	COG1414	Transcriptional regulator
E4W57_RS19505	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4W57_RS19510	COG1053	succinate dehydrogenase
E4W57_RS19520	COG1053	succinate dehydrogenase
E4W57_RS19535	COG0673	inositol 2-dehydrogenase activity
E4W57_RS19540	COG2814	Major facilitator Superfamily
E4W57_RS19550	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E4W57_RS19555	COG0693	protein deglycase activity
E4W57_RS19575	COG0142	geranyltranstransferase activity
E4W57_RS19585	COG0667	Aldo Keto reductase
E4W57_RS19590	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E4W57_RS19610	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4W57_RS19610	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4W57_RS19620	COG4238	major outer membrane lipoprotein
E4W57_RS19640	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4W57_RS19645	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4W57_RS19650	COG1862	Preprotein translocase
E4W57_RS19675	COG0450	alkyl hydroperoxide reductase
E4W57_RS19685	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4W57_RS19700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4W57_RS19710	COG1228	amidohydrolase
E4W57_RS19720	COG1335	isochorismatase
E4W57_RS19725	COG0583	DNA-binding transcription factor activity
E4W57_RS19730	COG0366	Alpha amylase catalytic
E4W57_RS19755	COG0420	3'-5' exonuclease activity
E4W57_RS19760	COG0419	ATPase involved in DNA repair
E4W57_RS19765	COG1940	carbohydrate kinase activity
E4W57_RS19780	COG4126	flavin adenine dinucleotide binding
E4W57_RS19790	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E4W57_RS19795	COG3416	Protein conserved in bacteria
E4W57_RS19805	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E4W57_RS19815	COG1785	Belongs to the alkaline phosphatase family
E4W57_RS19855	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
E4W57_RS19860	COG1335	isochorismatase
E4W57_RS19865	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4W57_RS19870	COG0113	porphobilinogen synthase activity
E4W57_RS19880	COG2175	clavaminate synthase activity
E4W57_RS19885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4W57_RS19890	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E4W57_RS19895	COG4521	taurine ABC transporter
E4W57_RS19900	COG2040	homocysteine
E4W57_RS19905	COG0833	amino acid
E4W57_RS19915	COG0531	amino acid
E4W57_RS19920	COG4303	Ethanolamine ammonia lyase large subunit
E4W57_RS19925	COG4302	ethanolamine ammonia-lyase activity
E4W57_RS19965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4W57_RS19970	COG1126	abc transporter atp-binding protein
E4W57_RS19975	COG0765	amino acid transport
E4W57_RS19980	COG0765	amino acid transport
E4W57_RS19995	COG3188	usher protein
E4W57_RS20020	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
E4W57_RS20030	COG3639	organic phosphonate transmembrane transporter activity
E4W57_RS20050	COG0791	NLP P60 protein
E4W57_RS20085	COG3188	usher protein
E4W57_RS20090	COG3121	Chaperone
E4W57_RS20095	COG3539	Fimbrial protein
E4W57_RS20145	COG2200	EAL domain
E4W57_RS20165	COG3121	Chaperone
E4W57_RS20190	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
E4W57_RS20205	COG0579	oxidoreductase
E4W57_RS20210	COG1012	belongs to the aldehyde dehydrogenase family
E4W57_RS20215	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E4W57_RS20220	COG1113	amino acid transport
E4W57_RS20225	COG1802	Transcriptional regulator
E4W57_RS20245	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4W57_RS20250	COG0454	-acetyltransferase
E4W57_RS20265	COG2991	Protein conserved in bacteria
E4W57_RS20280	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4W57_RS20285	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4W57_RS20300	COG3034	peptidoglycan biosynthetic process
E4W57_RS20305	COG0121	glutamine amidotransferase
E4W57_RS20315	COG1960	acyl-CoA dehydrogenase activity
E4W57_RS20320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4W57_RS20330	COG0583	DNA-binding transcription factor activity
E4W57_RS20340	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4W57_RS20350	COG2226	methyltransferase
E4W57_RS20360	COG1388	LysM domain
E4W57_RS20360	COG0741	lytic transglycosylase activity
E4W57_RS20365	COG2226	methyltransferase
E4W57_RS20375	COG2814	Major facilitator Superfamily
E4W57_RS20380	COG0583	DNA-binding transcription factor activity
E4W57_RS20385	COG0656	L-ascorbic acid biosynthetic process
E4W57_RS20420	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E4W57_RS20430	COG2011	ABC-type metal ion transport system permease component
E4W57_RS20435	COG1464	Belongs to the NlpA lipoprotein family
E4W57_RS20445	COG1720	tRNA m6t6A37 methyltransferase activity
E4W57_RS20455	COG0791	NLP P60 protein
E4W57_RS20460	COG3015	lipoprotein NlpE involved in copper resistance
E4W57_RS20465	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E4W57_RS20480	COG4568	rho-dependent transcription termination
E4W57_RS20490	COG0346	lactoylglutathione lyase activity
E4W57_RS20505	COG0587	DNA-directed DNA polymerase activity
E4W57_RS20535	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
E4W57_RS20545	COG0750	zinc metalloprotease
E4W57_RS20550	COG0575	Belongs to the CDS family
E4W57_RS20560	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E4W57_RS20585	COG0024	Methionine aminopeptidase
E4W57_RS20590	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E4W57_RS20605	COG3835	regulator
E4W57_RS20610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4W57_RS20630	COG2860	membrane
E4W57_RS20650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4W57_RS20655	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4W57_RS20660	COG1120	ATPase activity
E4W57_RS20665	COG4774	siderophore transport
E4W57_RS20670	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4W57_RS20765	COG1643	Atp-dependent helicase
E4W57_RS20770	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
E4W57_RS20790	COG0617	tRNA 3'-terminal CCA addition
E4W57_RS20795	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E4W57_RS20815	COG0726	polysaccharide deacetylase
E4W57_RS20820	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4W57_RS20825	COG0842	Transport permease protein
E4W57_RS20830	COG1131	(ABC) transporter
E4W57_RS20835	COG0288	reversible hydration of carbon dioxide
E4W57_RS20850	COG4993	Dehydrogenase
E4W57_RS20855	COG2132	Multicopper oxidase
E4W57_RS20900	COG3064	Membrane
E4W57_RS20915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4W57_RS20920	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4W57_RS20925	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E4W57_RS20930	COG2186	Transcriptional regulator
E4W57_RS20935	COG1113	amino acid transport
E4W57_RS20940	COG2211	Major facilitator Superfamily
E4W57_RS20945	COG3940	Belongs to the glycosyl hydrolase 43 family
E4W57_RS20950	COG3725	Membrane protein required for beta-lactamase induction
E4W57_RS20955	COG3023	N-Acetylmuramoyl-L-alanine amidase
E4W57_RS20965	COG4969	Belongs to the N-Me-Phe pilin family
E4W57_RS20970	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4W57_RS20975	COG1459	type II secretion system
E4W57_RS21000	COG0494	nUDIX hydrolase
E4W57_RS21020	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4W57_RS21025	COG0849	cell division
E4W57_RS21050	COG0772	Belongs to the SEDS family
E4W57_RS21065	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4W57_RS21070	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4W57_RS21075	COG0768	penicillin binding
E4W57_RS21095	COG1609	Transcriptional regulator
E4W57_RS21105	COG0028	Belongs to the TPP enzyme family
E4W57_RS21150	COG0738	Major facilitator superfamily
E4W57_RS21160	COG0583	DNA-binding transcription factor activity
E4W57_RS21165	COG2271	Major facilitator Superfamily
E4W57_RS21170	COG2814	Major facilitator Superfamily
E4W57_RS21190	COG1178	ABC-type Fe3 transport system permease component
E4W57_RS21200	COG0586	Pfam SNARE associated Golgi protein
E4W57_RS21220	COG0235	Class ii aldolase
E4W57_RS21225	COG0417	DNA replication proofreading
E4W57_RS21235	COG0564	pseudouridine synthase activity
E4W57_RS21245	COG3493	citrate carrier protein
E4W57_RS21260	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E4W57_RS21265	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E4W57_RS21275	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E4W57_RS21320	COG0505	Belongs to the CarA family
E4W57_RS21385	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4W57_RS21410	COG1047	Peptidyl-prolyl cis-trans
E4W57_RS21425	COG0196	riboflavin kinase activity
E4W57_RS21435	COG0583	DNA-binding transcription factor activity
E4W57_RS21460	COG4735	regulation of single-species biofilm formation
E4W57_RS21465	COG1584	GPR1 FUN34 yaaH family protein
E4W57_RS21470	COG0477	Major facilitator Superfamily
E4W57_RS21475	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4W57_RS21480	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4W57_RS21485	COG1115	amino acid carrier protein
E4W57_RS21500	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4W57_RS21510	COG0460	homoserine dehydrogenase
E4W57_RS21510	COG0527	aspartate kinase activity
E4W57_RS21520	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E4W57_RS21530	COG0745	RESPONSE REGULATOR receiver
E4W57_RS21535	COG4452	Inner membrane protein CreD
E4W57_RS21540	COG2205	protein histidine kinase activity
E4W57_RS21545	COG0745	RESPONSE REGULATOR receiver
E4W57_RS21550	COG3045	CreA protein
E4W57_RS21555	COG2207	Transcriptional regulator
E4W57_RS21555	COG3708	Transcriptional regulator
E4W57_RS21575	COG0741	lytic transglycosylase activity
E4W57_RS21580	COG0488	(ABC) transporter
E4W57_RS21590	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E4W57_RS21595	COG0560	Phosphoserine phosphatase
E4W57_RS21600	COG3726	membrane protein affecting hemolysin expression
E4W57_RS21630	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4W57_RS21635	COG0084	hydrolase, TatD family'
E4W57_RS21640	COG4667	esterase of the alpha-beta hydrolase superfamily
E4W57_RS21650	COG2823	Periplasmic or secreted lipoprotein
E4W57_RS21660	COG1011	Hydrolase
E4W57_RS21665	COG0456	acetyltransferase
E4W57_RS21670	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
E4W57_RS21705	COG3706	GGDEF domain
E4W57_RS21710	COG4114	ferric iron reductase
E4W57_RS21715	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4W57_RS21715	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4W57_RS21720	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E4W57_RS21725	COG2197	response regulator
E4W57_RS21730	COG2197	response regulator
E4W57_RS21745	COG2966	Psort location CytoplasmicMembrane, score
E4W57_RS21760	COG1484	DNA-dependent DNA replication
E4W57_RS21775	COG5464	transposase or invertase
E4W57_RS21785	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E4W57_RS21790	COG3716	PTS system mannose fructose sorbose family IID component
E4W57_RS21795	COG3715	PTS system
E4W57_RS21810	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E4W57_RS21810	COG3933	PFAM sigma-54 factor interaction domain-containing protein
E4W57_RS21815	COG1214	PFAM Peptidase M22, glycoprotease
E4W57_RS21815	COG0456	acetyltransferase
E4W57_RS21825	COG1737	Transcriptional regulator
E4W57_RS21830	COG0800	Aldolase
E4W57_RS21835	COG3734	2-keto-3-deoxy-galactonokinase
E4W57_RS21840	COG4145	pantothenate transmembrane transporter activity
E4W57_RS21850	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
E4W57_RS21870	COG0531	amino acid
E4W57_RS21875	COG1012	belongs to the aldehyde dehydrogenase family
E4W57_RS21880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4W57_RS21895	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E4W57_RS21895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4W57_RS21910	COG1846	Transcriptional regulator
E4W57_RS21920	COG0179	Fumarylacetoacetate (FAA) hydrolase
E4W57_RS21930	COG1012	belongs to the aldehyde dehydrogenase family
E4W57_RS21935	COG3384	dioxygenase
E4W57_RS21945	COG3971	2-oxopent-4-enoate hydratase activity
E4W57_RS21965	COG2368	4-hydroxyphenylacetate
E4W57_RS21970	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4W57_RS21975	COG1966	Carbon starvation protein
E4W57_RS21980	COG2879	small protein
E4W57_RS21985	COG0523	cobalamin synthesis protein
E4W57_RS21995	COG1012	belongs to the aldehyde dehydrogenase family
E4W57_RS22000	COG5464	transposase or invertase
E4W57_RS22005	COG2207	Transcriptional regulator
E4W57_RS22005	COG1917	Cupin 2, conserved barrel domain protein
E4W57_RS22015	COG2733	membrane
E4W57_RS22030	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E4W57_RS22035	COG1924	4 iron, 4 sulfur cluster binding
E4W57_RS22050	COG1566	PFAM secretion protein HlyD family protein
E4W57_RS22060	COG5457	Domain of unknown function (DUF1127)
E4W57_RS22065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4W57_RS22075	COG0583	DNA-binding transcription factor activity
E4W57_RS22080	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4W57_RS22115	COG1012	belongs to the aldehyde dehydrogenase family
E4W57_RS22115	COG1454	alcohol dehydrogenase
E4W57_RS22130	COG1882	Formate acetyltransferase
E4W57_RS22135	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4W57_RS22145	COG4869	propanediol catabolic process
E4W57_RS22170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4W57_RS22175	COG0842	Transport permease protein
E4W57_RS22175	COG1129	ABC transporter
E4W57_RS22180	COG0842	Transport permease protein
E4W57_RS22210	COG2850	peptidyl-arginine hydroxylation
E4W57_RS22225	COG5002	protein histidine kinase activity
E4W57_RS22230	COG0745	RESPONSE REGULATOR receiver
E4W57_RS22235	COG1538	Outer membrane efflux protein
E4W57_RS22240	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4W57_RS22245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4W57_RS22250	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4W57_RS22260	COG3040	lipid binding
E4W57_RS22265	COG0789	Transcriptional regulator
E4W57_RS22275	COG0300	oxidoreductase activity
E4W57_RS22290	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E4W57_RS22310	COG3272	Protein of unknown function (DUF1722)
E4W57_RS22315	COG4580	involved in the transport of maltose and maltodextrins
E4W57_RS22320	COG2115	Belongs to the xylose isomerase family
E4W57_RS22325	COG2211	Major facilitator Superfamily
E4W57_RS22330	COG3507	Belongs to the glycosyl hydrolase 43 family
E4W57_RS22350	COG1216	Glycosyl transferase, family 2
E4W57_RS22395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4W57_RS22430	COG2003	Belongs to the UPF0758 family
E4W57_RS22450	COG3596	GTP binding
E4W57_RS22475	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4W57_RS22480	COG0732	type I restriction modification DNA specificity domain
E4W57_RS22490	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E4W57_RS22515	COG0582	viral genome integration into host DNA
E4W57_RS22525	COG0288	reversible hydration of carbon dioxide
E4W57_RS22530	COG0659	secondary active sulfate transmembrane transporter activity
E4W57_RS22535	COG1064	alcohol dehydrogenase
E4W57_RS22540	COG1175	transmembrane transport
E4W57_RS22545	COG0395	ABC-type sugar transport system, permease component
E4W57_RS22550	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E4W57_RS22555	COG3842	ATPase activity
E4W57_RS22570	COG1082	Xylose isomerase domain protein TIM barrel
E4W57_RS22580	COG3962	Belongs to the TPP enzyme family
E4W57_RS22585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4W57_RS22590	COG0837	glucose binding
E4W57_RS22590	COG1737	Transcriptional regulator
E4W57_RS22595	COG3718	enzyme involved in inositol metabolism
E4W57_RS22610	COG0433	COG0433 Predicted ATPase
E4W57_RS22615	COG0795	lipopolysaccharide-transporting ATPase activity
E4W57_RS22620	COG0795	lipopolysaccharide-transporting ATPase activity
E4W57_RS22630	COG2927	DNA polymerase III (CHI subunit)
E4W57_RS22635	COG0525	valine-tRNA ligase activity
E4W57_RS22660	COG2188	Transcriptional regulator
E4W57_RS22665	COG1288	antiporter activity
E4W57_RS22670	COG1228	amidohydrolase
E4W57_RS22675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4W57_RS22680	COG2222	sugar isomerase
E4W57_RS22685	COG2731	YhcH YjgK YiaL family protein
E4W57_RS22720	COG1263	PTS System
E4W57_RS22720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4W57_RS22725	COG0366	Alpha amylase catalytic
E4W57_RS22730	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4W57_RS22735	COG1486	melibiose metabolic process
E4W57_RS22760	COG0602	queuosine metabolic process
E4W57_RS22765	COG2026	Addiction module toxin, RelE StbE family
E4W57_RS22770	COG3077	Addiction module antitoxin, RelB DinJ family
E4W57_RS22775	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4W57_RS22775	COG3711	transcriptional antiterminator
E4W57_RS22780	COG2706	6-phosphogluconolactonase activity
E4W57_RS22795	COG3964	amidohydrolase
E4W57_RS22830	COG0312	modulator of DNA gyrase
E4W57_RS22850	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4W57_RS22860	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4W57_RS22865	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4W57_RS22870	COG1129	ABC transporter
E4W57_RS22875	COG1879	ABC-type sugar transport system periplasmic component
E4W57_RS22900	COG2105	PFAM AIG2 family protein
E4W57_RS22905	COG2911	Protein conserved in bacteria
E4W57_RS22910	COG0729	surface antigen
E4W57_RS22920	COG1253	flavin adenine dinucleotide binding
E4W57_RS22945	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
E4W57_RS22960	COG1733	regulation of RNA biosynthetic process
E4W57_RS22965	COG0702	epimerase
E4W57_RS22975	COG0697	spore germination
E4W57_RS22985	COG1113	amino acid transport
E4W57_RS22990	COG0545	Peptidyl-prolyl cis-trans isomerase
E4W57_RS22995	COG3061	Opacity-associated protein A
E4W57_RS23005	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4W57_RS23010	COG2965	DNA replication, synthesis of RNA primer
E4W57_RS23070	COG1073	alpha beta
E4W57_RS23075	COG3650	response to hydrogen peroxide
E4W57_RS23085	COG1960	acyl-CoA dehydrogenase activity
E4W57_RS23090	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4W57_RS23095	COG0557	exoribonuclease II activity
E4W57_RS23110	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
E4W57_RS23120	COG0330	HflC and HflK could
E4W57_RS23125	COG0330	HflC and HflK could
E4W57_RS23130	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4W57_RS23150	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4W57_RS23155	COG0802	atpase or kinase
E4W57_RS23160	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4W57_RS23160	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4W57_RS23165	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E4W57_RS23185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4W57_RS23205	COG3264	Mechanosensitive ion channel
E4W57_RS23205	COG1511	domain protein
E4W57_RS23220	COG1053	succinate dehydrogenase
E4W57_RS23225	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E4W57_RS23245	COG2076	Multidrug Resistance protein
E4W57_RS23250	COG5510	response to toxic substance
E4W57_RS23265	COG1509	lysine 2,3-aminomutase activity
E4W57_RS23270	COG0745	RESPONSE REGULATOR receiver
E4W57_RS23305	COG3188	usher protein
E4W57_RS23310	COG3539	Fimbrial protein
E4W57_RS23330	COG0531	amino acid
E4W57_RS23335	COG3030	protein affecting phage T7 exclusion by the F plasmid
E4W57_RS23340	COG1027	Aspartate ammonia-lyase
E4W57_RS23345	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E4W57_RS23360	COG1309	transcriptional regulator
E4W57_RS23390	COG0457	Tetratricopeptide repeat
E4W57_RS23395	COG0726	polysaccharide deacetylase
E4W57_RS23395	COG1649	PFAM Uncharacterised BCR, COG1649
E4W57_RS23400	COG1215	transferase activity, transferring glycosyl groups
E4W57_RS23415	COG0861	Integral membrane protein TerC family
E4W57_RS23455	COG1486	melibiose metabolic process
E4W57_RS23460	COG2169	Transcriptional regulator
E4W57_RS23470	COG2824	Alkylphosphonate utilization operon protein PhnA
E4W57_RS23475	COG2764	glyoxalase bleomycin resistance protein dioxygenase
E4W57_RS23480	COG2188	Transcriptional regulator
E4W57_RS23485	COG3624	Phosphonate C-P lyase system protein PhnG
E4W57_RS23490	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
E4W57_RS23495	COG3626	phosphonate metabolism
E4W57_RS23500	COG3627	carbon phosphorus lyase activity
E4W57_RS23505	COG4107	phosphonate C-P lyase system protein PhnK
E4W57_RS23510	COG4778	phosphonate C-P lyase system protein PhnL
E4W57_RS23515	COG3454	Phosphonate metabolism
E4W57_RS23525	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E4W57_RS23535	COG0784	Response regulator, receiver
E4W57_RS23535	COG4191	Histidine kinase
E4W57_RS23540	COG1129	ABC transporter
E4W57_RS23545	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4W57_RS23580	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E4W57_RS23585	COG1301	dicarboxylic acid transport
E4W57_RS23595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4W57_RS23600	COG3162	membrane
E4W57_RS23630	COG3539	Fimbrial protein
E4W57_RS23635	COG1346	cytolysis
E4W57_RS23640	COG1380	Effector of murein hydrolase LrgA
E4W57_RS23645	COG0583	DNA-binding transcription factor activity
E4W57_RS23650	COG0025	NhaP-type Na H and K H
E4W57_RS23655	COG2252	PERMEase
E4W57_RS23660	COG0625	glutathione transferase activity
E4W57_RS23665	COG0789	Transcriptional regulator
E4W57_RS23675	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E4W57_RS23705	COG1234	tRNA 3'-trailer cleavage
E4W57_RS23710	COG1609	Transcriptional regulator
E4W57_RS23715	COG0483	inositol monophosphate 1-phosphatase activity
E4W57_RS23725	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4W57_RS23745	COG4771	TonB-dependent receptor
E4W57_RS23750	COG0741	lytic transglycosylase activity
E4W57_RS23765	COG2315	Protein conserved in bacteria
E4W57_RS23770	COG0432	Pfam Uncharacterised protein family UPF0047
E4W57_RS23785	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4W57_RS23790	COG0305	Participates in initiation and elongation during chromosome replication
E4W57_RS23805	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4W57_RS23815	COG0735	belongs to the Fur family
E4W57_RS23820	COG3237	CsbD-like
E4W57_RS23830	COG0534	Mate efflux family protein
E4W57_RS23840	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E4W57_RS23910	COG0251	oxidation-reduction process
E4W57_RS23920	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E4W57_RS23930	COG0527	aspartate kinase activity
E4W57_RS23985	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4W57_RS24015	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E4W57_RS24025	COG0456	acetyltransferase
E4W57_RS24055	COG0151	Belongs to the GarS family
E4W57_RS24065	COG4191	Histidine kinase
E4W57_RS24070	COG3678	ATP-independent chaperone mediated protein folding
E4W57_RS24105	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
E4W57_RS24120	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4W57_RS24125	COG2104	thiamine diphosphate biosynthetic process
E4W57_RS24140	COG3706	GGDEF domain
E4W57_RS24150	COG1447	Phosphotransferase system cellobiose-specific component IIA
E4W57_RS24155	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E4W57_RS24190	COG0250	Participates in transcription elongation, termination and antitermination
E4W57_RS24265	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
E4W57_RS24275	COG1739	Uncharacterized protein family UPF0029
E4W57_RS24315	COG0805	protein transport
E4W57_RS24335	COG3165	ubiquinone biosynthetic process from chorismate
E4W57_RS24365	COG0583	DNA-binding transcription factor activity
E4W57_RS24370	COG0697	spore germination
E4W57_RS24375	COG0561	phosphatase activity
E4W57_RS24380	COG2267	carboxylic ester hydrolase activity
E4W57_RS24385	COG1280	lysine exporter protein (LysE YggA)
E4W57_RS24395	COG1280	lysine exporter protein (LysE YggA)
E4W57_RS24425	COG0210	DNA helicase
E4W57_RS24430	COG1011	Hydrolase
E4W57_RS24460	COG3072	Adenylate cyclase
E4W57_RS24475	COG2959	enzyme of heme biosynthesis
E4W57_RS24480	COG3071	HemY protein
E4W57_RS24525	COG2244	polysaccharide biosynthetic process
E4W57_RS24530	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4W57_RS24535	COG0456	acetyltransferase
E4W57_RS24540	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E4W57_RS24545	COG1088	dTDP-glucose 4,6-dehydratase activity
E4W57_RS24550	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E4W57_RS24555	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E4W57_RS24565	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4W57_RS24570	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E4W57_RS24575	COG3118	belongs to the thioredoxin family
E4W57_RS24600	COG1811	Na channel or pump
E4W57_RS24610	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4W57_RS24615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4W57_RS24625	COG0583	DNA-binding transcription factor activity
E4W57_RS24630	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4W57_RS24645	COG3978	acetolactate synthase activity
E4W57_RS24665	COG3085	chromosome segregation
E4W57_RS24740	COG0583	DNA-binding transcription factor activity
E4W57_RS24755	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E4W57_RS24770	COG3443	Belongs to the bacterial solute-binding protein 9 family
E4W57_RS24775	COG2207	Transcriptional regulator
E4W57_RS24785	COG0371	Dehydrogenase
E4W57_RS24790	COG0697	spore germination
E4W57_RS24800	COG0583	DNA-binding transcription factor activity
E4W57_RS24810	COG0737	Belongs to the 5'-nucleotidase family
E4W57_RS24820	COG0527	aspartate kinase activity
E4W57_RS24820	COG0460	homoserine dehydrogenase
E4W57_RS24825	COG0626	cystathionine gamma-synthase activity
E4W57_RS24840	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4W57_RS24845	COG1609	Transcriptional regulator
E4W57_RS24850	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4W57_RS24865	COG1575	Belongs to the MenA family. Type 1 subfamily
E4W57_RS24885	COG3678	ATP-independent chaperone mediated protein folding
E4W57_RS24890	COG0745	RESPONSE REGULATOR receiver
E4W57_RS24895	COG2205	protein histidine kinase activity
E4W57_RS24900	COG2258	MOSC domain
E4W57_RS24905	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E4W57_RS24945	COG1129	ABC transporter
E4W57_RS24950	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4W57_RS24955	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4W57_RS24960	COG1454	alcohol dehydrogenase
E4W57_RS24970	COG2211	Major facilitator Superfamily
E4W57_RS25015	COG0437	4 iron, 4 sulfur cluster binding
E4W57_RS25020	COG2864	formate dehydrogenase
E4W57_RS25035	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4W57_RS25045	COG0456	acetyltransferase
E4W57_RS25060	COG1011	Hydrolase
E4W57_RS25075	COG3852	Histidine kinase
E4W57_RS25090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4W57_RS25110	COG0204	Acyl-transferase
E4W57_RS25120	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E4W57_RS25125	COG3084	Protein conserved in bacteria
E4W57_RS25135	COG1763	Mo-molybdopterin cofactor biosynthetic process
E4W57_RS25160	COG2186	Transcriptional regulator
E4W57_RS25165	COG0477	Major facilitator Superfamily
E4W57_RS25170	COG1609	Transcriptional regulator
E4W57_RS25175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4W57_RS25185	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4W57_RS25190	COG1129	ABC transporter
E4W57_RS25220	COG1522	sequence-specific DNA binding
E4W57_RS25225	COG0716	FMN binding
E4W57_RS25240	COG3312	ion transport
E4W57_RS25290	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E4W57_RS25295	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E4W57_RS25300	COG0573	inorganic phosphate transmembrane transporter activity
E4W57_RS25305	COG0581	inorganic phosphate transmembrane transporter activity
E4W57_RS25310	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E4W57_RS25315	COG0704	Plays a role in the regulation of phosphate uptake
E4W57_RS25325	COG2382	esterase
E4W57_RS25330	COG0363	glucosamine-6-phosphate deaminase activity
E4W57_RS25335	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4W57_RS25340	COG2252	PERMEase
E4W57_RS25345	COG0431	NADPH-dependent FMN reductase
E4W57_RS25350	COG2091	lysine biosynthetic process via aminoadipic acid
E4W57_RS25380	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E4W57_RS25405	COG2199	diguanylate cyclase activity
E4W57_RS25405	COG2203	Gaf domain
E4W57_RS25410	COG5001	Diguanylate cyclase
E4W57_RS25410	COG1716	ATPase activity
E4W57_RS25425	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E4W57_RS25490	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4W57_RS25520	COG0739	heme binding
E4W57_RS25530	COG2132	Multicopper oxidase
E4W57_RS25535	COG3667	copper resistance
E4W57_RS25540	COG2372	response to copper ion
E4W57_RS25545	COG1276	copper resistance
E4W57_RS25550	COG0745	RESPONSE REGULATOR receiver
E4W57_RS25555	COG2205	protein histidine kinase activity
E4W57_RS25600	COG0402	S-adenosylhomocysteine deaminase activity
E4W57_RS25605	COG2188	Transcriptional regulator
E4W57_RS25615	COG2986	histidine ammonia-lyase
E4W57_RS25645	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E4W57_RS25650	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E4W57_RS25675	COG2801	Transposase and inactivated derivatives
E4W57_RS25705	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4W57_RS25730	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E4W57_RS25755	COG4598	ABC transporter
E4W57_RS25775	COG0583	DNA-binding transcription factor activity
E4W57_RS25790	COG1595	DNA-templated transcription, initiation
E4W57_RS25795	COG3712	iron ion homeostasis
E4W57_RS25800	COG4772	TonB-dependent receptor
E4W57_RS25805	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
E4W57_RS25810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4W57_RS25815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4W57_RS25820	COG1120	ATPase activity
E4W57_RS25825	COG3436	PFAM IS66 Orf2 family protein
E4W57_RS25850	COG1609	Transcriptional regulator
E4W57_RS25860	COG2223	nitrite transmembrane transporter activity
E4W57_RS25900	COG2801	Transposase and inactivated derivatives
E4W57_RS25925	COG1660	Displays ATPase and GTPase activities
E4W57_RS26110	COG4644	lycopene metabolic process
E4W57_RS26130	COG0697	spore germination
E4W57_RS26160	COG0840	transmembrane signaling receptor activity
E4W57_RS26170	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E4W57_RS26180	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E4W57_RS26225	COG3621	Patatin-like phospholipase
E4W57_RS26290	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E4W57_RS26300	COG3012	SEC-C Motif Domain Protein
E4W57_RS26300	COG3318	Belongs to the UPF0149 family
E4W57_RS26335	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities