locus-tag	class	description
HVY73_RS00020	COG0187	DNA topoisomerase II activity
HVY73_RS00025	COG0561	phosphatase activity
HVY73_RS00040	COG2186	Transcriptional regulator
HVY73_RS00045	COG3734	2-keto-3-deoxy-galactonokinase
HVY73_RS00050	COG0800	Aldolase
HVY73_RS00060	COG2271	Major facilitator Superfamily
HVY73_RS00065	COG0823	Involved in the tonB-independent uptake of proteins
HVY73_RS00070	COG5645	(Lipo)protein
HVY73_RS00095	COG2188	Transcriptional regulator
HVY73_RS00110	COG2149	membrane
HVY73_RS00130	COG2610	gluconate transmembrane transporter activity
HVY73_RS00140	COG0583	DNA-binding transcription factor activity
HVY73_RS00145	COG2814	Major facilitator Superfamily
HVY73_RS00175	COG0028	Belongs to the TPP enzyme family
HVY73_RS00180	COG0440	acetolactate synthase activity
HVY73_RS00185	COG2197	response regulator
HVY73_RS00195	COG2271	Major facilitator Superfamily
HVY73_RS00235	COG2188	Transcriptional regulator
HVY73_RS00260	COG4580	involved in the transport of maltose and maltodextrins
HVY73_RS00265	COG1447	Phosphotransferase system cellobiose-specific component IIA
HVY73_RS00270	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVY73_RS00270	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVY73_RS00280	COG1609	Transcriptional regulator
HVY73_RS00290	COG3384	dioxygenase
HVY73_RS00295	COG0583	DNA-binding transcription factor activity
HVY73_RS00300	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HVY73_RS00305	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HVY73_RS00310	COG2828	Protein conserved in bacteria
HVY73_RS00325	COG0697	spore germination
HVY73_RS00330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY73_RS00330	COG1263	PTS System
HVY73_RS00340	COG2814	Major facilitator Superfamily
HVY73_RS00350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVY73_RS00375	COG1309	transcriptional regulator
HVY73_RS00385	COG0583	DNA-binding transcription factor activity
HVY73_RS00410	COG1464	Belongs to the NlpA lipoprotein family
HVY73_RS00425	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HVY73_RS00435	COG1064	alcohol dehydrogenase
HVY73_RS00465	COG2211	Major facilitator Superfamily
HVY73_RS00470	COG1501	Belongs to the glycosyl hydrolase 31 family
HVY73_RS00480	COG1486	melibiose metabolic process
HVY73_RS00485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY73_RS00485	COG1263	PTS System
HVY73_RS00490	COG2982	Protein involved in outer membrane biogenesis
HVY73_RS00495	COG2233	PERMEase
HVY73_RS00500	COG0786	glutamate:sodium symporter activity
HVY73_RS00520	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HVY73_RS00545	COG3152	Membrane
HVY73_RS00555	COG1494	fructose-1,6-bisphosphatase
HVY73_RS00560	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HVY73_RS00565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVY73_RS00570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HVY73_RS00590	COG2860	membrane
HVY73_RS00600	COG2169	Transcriptional regulator
HVY73_RS00600	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HVY73_RS00605	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HVY73_RS00610	COG1561	YicC-like family, N-terminal region
HVY73_RS00630	COG1131	(ABC) transporter
HVY73_RS00635	COG0842	Transport permease protein
HVY73_RS00660	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HVY73_RS00695	COG1519	Transferase
HVY73_RS00700	COG1216	Glycosyl transferase, family 2
HVY73_RS00705	COG0438	transferase activity, transferring glycosyl groups
HVY73_RS00715	COG0859	PFAM glycosyl transferase family 9
HVY73_RS00740	COG0859	PFAM glycosyl transferase family 9
HVY73_RS00755	COG0156	8-amino-7-oxononanoate synthase activity
HVY73_RS00765	COG0463	Glycosyl transferase, family 2
HVY73_RS00770	COG2861	carbohydrate metabolic process
HVY73_RS00775	COG4942	peptidase
HVY73_RS00785	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HVY73_RS00790	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HVY73_RS00810	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HVY73_RS00820	COG2186	Transcriptional regulator
HVY73_RS00840	COG3722	fumarate hydratase activity
HVY73_RS00860	COG1566	PFAM secretion protein HlyD family protein
HVY73_RS00865	COG0625	glutathione transferase activity
HVY73_RS00875	COG3276	selenocysteine insertion sequence binding
HVY73_RS00880	COG1414	Transcriptional regulator
HVY73_RS00885	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY73_RS00890	COG3977	Valine--pyruvate aminotransferase
HVY73_RS00895	COG0366	Alpha amylase catalytic
HVY73_RS00900	COG2992	FlgJ-related protein
HVY73_RS00905	COG1609	Transcriptional regulator
HVY73_RS00905	COG2207	Transcriptional regulator
HVY73_RS00910	COG4214	carbohydrate transport
HVY73_RS00920	COG4213	ABC transporter substrate-binding protein
HVY73_RS00935	COG4682	membrane
HVY73_RS00940	COG4682	membrane
HVY73_RS00945	COG3274	enterobacterial common antigen metabolic process
HVY73_RS00970	COG0488	(ABC) transporter
HVY73_RS00975	COG1278	Cold shock
HVY73_RS00980	COG2944	sequence-specific DNA binding
HVY73_RS00985	COG2814	Major facilitator Superfamily
HVY73_RS01005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY73_RS01015	COG1609	Transcriptional regulator
HVY73_RS01020	COG2885	chlorophyll binding
HVY73_RS01025	COG0243	molybdopterin cofactor binding
HVY73_RS01030	COG0456	acetyltransferase
HVY73_RS01035	COG2818	Glycosylase
HVY73_RS01040	COG5571	outer membrane autotransporter
HVY73_RS01045	COG2223	nitrite transmembrane transporter activity
HVY73_RS01075	COG0747	negative chemotaxis
HVY73_RS01080	COG0601	transmembrane transport
HVY73_RS01085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVY73_RS01090	COG0444	Belongs to the ABC transporter superfamily
HVY73_RS01095	COG4608	Belongs to the ABC transporter superfamily
HVY73_RS01110	COG2894	cell division
HVY73_RS01120	COG1215	transferase activity, transferring glycosyl groups
HVY73_RS01125	COG0457	Tetratricopeptide repeat
HVY73_RS01140	COG2194	sulfuric ester hydrolase activity
HVY73_RS01170	COG1215	transferase activity, transferring glycosyl groups
HVY73_RS01175	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HVY73_RS01180	COG0457	Tetratricopeptide repeat
HVY73_RS01180	COG3118	belongs to the thioredoxin family
HVY73_RS01185	COG2200	EAL domain
HVY73_RS01185	COG2199	diguanylate cyclase activity
HVY73_RS01195	COG0612	Peptidase, M16
HVY73_RS01205	COG2982	Protein involved in outer membrane biogenesis
HVY73_RS01210	COG0477	Major facilitator Superfamily
HVY73_RS01215	COG1295	ribonuclease BN
HVY73_RS01220	COG0583	DNA-binding transcription factor activity
HVY73_RS01225	COG1028	Short-chain dehydrogenase reductase Sdr
HVY73_RS01230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVY73_RS01240	COG1454	alcohol dehydrogenase
HVY73_RS01250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVY73_RS01255	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HVY73_RS01260	COG0671	phosphoesterase, PA-phosphatase related
HVY73_RS01280	COG0589	response to stress
HVY73_RS01290	COG0306	phosphate transporter
HVY73_RS01295	COG2081	HI0933 family
HVY73_RS01300	COG2239	Acts as a magnesium transporter
HVY73_RS01310	COG1124	(ABC) transporter
HVY73_RS01320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVY73_RS01325	COG0601	transmembrane transport
HVY73_RS01330	COG0747	negative chemotaxis
HVY73_RS01340	COG3479	Phenolic acid decarboxylase
HVY73_RS01380	COG0628	permease
HVY73_RS01385	COG0477	Major facilitator Superfamily
HVY73_RS01395	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HVY73_RS01410	COG3714	YhhN family
HVY73_RS01420	COG3776	membrane
HVY73_RS01425	COG0742	ribosomal rna small subunit methyltransferase
HVY73_RS01430	COG0552	protein localization to endoplasmic reticulum
HVY73_RS01435	COG2884	Cell division ATP-binding protein ftsE
HVY73_RS01440	COG2177	Part of the ABC transporter FtsEX involved in
HVY73_RS01455	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HVY73_RS01465	COG0683	leucine binding
HVY73_RS01470	COG0456	acetyltransferase
HVY73_RS01475	COG0683	leucine binding
HVY73_RS01480	COG0559	Belongs to the binding-protein-dependent transport system permease family
HVY73_RS01530	COG0584	glycerophosphoryl diester phosphodiesterase
HVY73_RS01540	COG0405	Gamma-glutamyltransferase
HVY73_RS01545	COG1247	-acetyltransferase
HVY73_RS01555	COG0673	inositol 2-dehydrogenase activity
HVY73_RS01560	COG1741	Belongs to the pirin family
HVY73_RS01565	COG1609	Transcriptional regulator
HVY73_RS01570	COG3265	gluconokinase activity
HVY73_RS01575	COG2610	gluconate transmembrane transporter activity
HVY73_RS01585	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HVY73_RS01610	COG0058	SHG alpha-glucan phosphorylase activity
HVY73_RS01625	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HVY73_RS01640	COG1349	DNA-binding transcription factor activity
HVY73_RS01650	COG0058	SHG alpha-glucan phosphorylase activity
HVY73_RS01655	COG1640	4-alpha-glucanotransferase
HVY73_RS01660	COG2610	gluconate transmembrane transporter activity
HVY73_RS01670	COG1040	competence protein
HVY73_RS01695	COG1918	ferrous iron import across plasma membrane
HVY73_RS01700	COG2183	response to ionizing radiation
HVY73_RS01705	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HVY73_RS01710	COG0745	RESPONSE REGULATOR receiver
HVY73_RS01730	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HVY73_RS01735	COG1011	Hydrolase
HVY73_RS01745	COG0494	nUDIX hydrolase
HVY73_RS01750	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HVY73_RS01775	COG4796	Type ii and iii secretion system protein
HVY73_RS01790	COG3266	domain, Protein
HVY73_RS01795	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HVY73_RS01800	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HVY73_RS01825	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HVY73_RS01830	COG0402	S-adenosylhomocysteine deaminase activity
HVY73_RS01835	COG0738	Major facilitator superfamily
HVY73_RS01860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HVY73_RS01865	COG1289	transmembrane transporter activity
HVY73_RS01875	COG1765	OsmC-like protein
HVY73_RS01880	COG3954	Phosphoribulokinase
HVY73_RS01890	COG0429	hydrolase of the alpha beta-hydrolase fold
HVY73_RS01895	COG0488	(ABC) transporter
HVY73_RS01910	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HVY73_RS01915	COG1047	Peptidyl-prolyl cis-trans
HVY73_RS01925	COG0545	Peptidyl-prolyl cis-trans isomerase
HVY73_RS01930	COG2964	Protein conserved in bacteria
HVY73_RS01985	COG0051	transcription antitermination factor activity, RNA binding
HVY73_RS02010	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HVY73_RS02025	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HVY73_RS02090	COG0201	protein transport
HVY73_RS02115	COG0202	RNA polymerase activity
HVY73_RS02130	COG0789	Transcriptional regulator
HVY73_RS02135	COG3036	rescue of stalled ribosome
HVY73_RS02165	COG0758	DNA mediated transformation
HVY73_RS02175	COG0551	DNA topoisomerase type I activity
HVY73_RS02195	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HVY73_RS02230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVY73_RS02235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY73_RS02240	COG1309	transcriptional regulator
HVY73_RS02260	COG4145	pantothenate transmembrane transporter activity
HVY73_RS02265	COG3924	membrane
HVY73_RS02270	COG0439	Biotin carboxylase
HVY73_RS02275	COG0511	ligase activity, forming carbon-carbon bonds
HVY73_RS02300	COG2199	diguanylate cyclase activity
HVY73_RS02300	COG2200	EAL domain
HVY73_RS02305	COG1077	Cell shape determining protein MreB Mrl
HVY73_RS02310	COG1792	Involved in formation and maintenance of cell shape
HVY73_RS02315	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HVY73_RS02325	COG1530	ribonuclease E activity
HVY73_RS02330	COG3164	Protein of unknown function
HVY73_RS02335	COG0312	modulator of DNA gyrase
HVY73_RS02340	COG0583	DNA-binding transcription factor activity
HVY73_RS02355	COG1289	transmembrane transporter activity
HVY73_RS02360	COG2732	(Barnase) inhibitor
HVY73_RS02385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVY73_RS02390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVY73_RS02395	COG3105	Protein conserved in bacteria
HVY73_RS02400	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HVY73_RS02420	COG0625	glutathione transferase activity
HVY73_RS02425	COG2969	positive regulation of protein catabolic process
HVY73_RS02435	COG0493	'glutamate synthase
HVY73_RS02440	COG0070	glutamate synthase
HVY73_RS02440	COG0069	glutamate synthase activity
HVY73_RS02440	COG0067	glutamate synthase
HVY73_RS02445	COG1242	4 iron, 4 sulfur cluster binding
HVY73_RS02450	COG2271	Major facilitator Superfamily
HVY73_RS02455	COG1063	alcohol dehydrogenase
HVY73_RS02460	COG1312	Catalyzes the dehydration of D-mannonate
HVY73_RS02465	COG2198	Histidine kinase
HVY73_RS02465	COG0784	Response regulator, receiver
HVY73_RS02465	COG5002	protein histidine kinase activity
HVY73_RS02470	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HVY73_RS02475	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HVY73_RS02480	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY73_RS02490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY73_RS02495	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HVY73_RS02500	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HVY73_RS02505	COG1137	ATPase activity
HVY73_RS02510	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HVY73_RS02515	COG3117	lipopolysaccharide transmembrane transporter activity
HVY73_RS02520	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HVY73_RS02530	COG0530	calcium, potassium:sodium antiporter activity
HVY73_RS02535	COG1127	ABC transporter
HVY73_RS02540	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HVY73_RS02545	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HVY73_RS02550	COG2854	intermembrane phospholipid transfer
HVY73_RS02555	COG3113	response to antibiotic
HVY73_RS02560	COG5007	Belongs to the BolA IbaG family
HVY73_RS02570	COG3423	Transcriptional regulator
HVY73_RS02575	COG0142	geranyltranstransferase activity
HVY73_RS02590	COG0697	spore germination
HVY73_RS02600	COG2027	D-alanyl-D-alanine carboxypeptidase
HVY73_RS02610	COG1534	Rna-binding protein
HVY73_RS02620	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HVY73_RS02625	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HVY73_RS02635	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HVY73_RS02675	COG0195	Participates in both transcription termination and antitermination
HVY73_RS02720	COG0814	amino acid
HVY73_RS02745	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HVY73_RS02790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HVY73_RS02795	COG0826	peptidase U32
HVY73_RS02800	COG0826	peptidase U32
HVY73_RS02805	COG3154	lipid carrier protein
HVY73_RS02810	COG3153	acetyltransferase
HVY73_RS02825	COG0693	protein deglycase activity
HVY73_RS02830	COG0702	epimerase
HVY73_RS02835	COG0701	Predicted permease
HVY73_RS02840	COG2823	Periplasmic or secreted lipoprotein
HVY73_RS02860	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HVY73_RS02865	COG2721	sulfolactate sulfo-lyase activity
HVY73_RS02870	COG2271	Major facilitator Superfamily
HVY73_RS02880	COG2084	Dehydrogenase
HVY73_RS02885	COG1929	Belongs to the glycerate kinase type-1 family
HVY73_RS02910	COG1741	Belongs to the pirin family
HVY73_RS02915	COG0583	DNA-binding transcription factor activity
HVY73_RS02920	COG3152	Membrane
HVY73_RS02925	COG0435	Glutathione S-transferase
HVY73_RS02930	COG2259	Doxx family
HVY73_RS02940	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HVY73_RS02945	COG4575	ribosome binding
HVY73_RS02950	COG1422	Protein of unknown function (DUF1090)
HVY73_RS02960	COG0586	Pfam SNARE associated Golgi protein
HVY73_RS02965	COG2186	Transcriptional regulator
HVY73_RS02970	COG2271	Major facilitator Superfamily
HVY73_RS02980	COG2721	sulfolactate sulfo-lyase activity
HVY73_RS02995	COG0861	Integral membrane protein TerC family
HVY73_RS03000	COG0673	inositol 2-dehydrogenase activity
HVY73_RS03005	COG1451	nucleotide metabolic process
HVY73_RS03025	COG0446	pyridine nucleotide-disulphide oxidoreductase
HVY73_RS03025	COG1902	pentaerythritol trinitrate reductase activity
HVY73_RS03075	COG1695	Transcriptional regulator
HVY73_RS03080	COG2375	cellular response to nickel ion
HVY73_RS03095	COG1461	Dihydroxyacetone kinase
HVY73_RS03100	COG2376	Dihydroxyacetone kinase
HVY73_RS03170	COG3247	response to pH
HVY73_RS03180	COG2198	Histidine kinase
HVY73_RS03180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY73_RS03180	COG0784	Response regulator, receiver
HVY73_RS03180	COG2205	protein histidine kinase activity
HVY73_RS03185	COG2197	response regulator
HVY73_RS03210	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HVY73_RS03215	COG0358	DNA primase activity
HVY73_RS03220	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HVY73_RS03285	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HVY73_RS03300	COG4991	sh3 domain protein
HVY73_RS03305	COG3025	triphosphatase activity
HVY73_RS03330	COG2960	long-chain fatty acid transporting porin activity
HVY73_RS03345	COG3384	dioxygenase
HVY73_RS03350	COG0754	glutathionylspermidine amidase activity
HVY73_RS03365	COG0494	nUDIX hydrolase
HVY73_RS03370	COG3151	Protein conserved in bacteria
HVY73_RS03375	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HVY73_RS03380	COG3150	esterase
HVY73_RS03390	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HVY73_RS03395	COG2249	NAD(P)H dehydrogenase (quinone) activity
HVY73_RS03400	COG0642	Histidine kinase
HVY73_RS03410	COG3111	PFAM Bacterial OB fold (BOF) protein
HVY73_RS03415	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HVY73_RS03420	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HVY73_RS03425	COG0204	Acyl-transferase
HVY73_RS03430	COG2132	Multicopper oxidase
HVY73_RS03435	COG1032	radical SAM domain protein
HVY73_RS03445	COG0656	L-ascorbic acid biosynthetic process
HVY73_RS03450	COG1979	alcohol dehydrogenase
HVY73_RS03455	COG2207	Transcriptional regulator
HVY73_RS03460	COG0586	Pfam SNARE associated Golgi protein
HVY73_RS03465	COG0626	cystathionine gamma-synthase activity
HVY73_RS03475	COG0848	biopolymer transport protein
HVY73_RS03480	COG2211	Major facilitator Superfamily
HVY73_RS03505	COG0625	glutathione transferase activity
HVY73_RS03520	COG0754	glutathionylspermidine amidase activity
HVY73_RS03525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HVY73_RS03545	COG0583	DNA-binding transcription factor activity
HVY73_RS03550	COG0626	cystathionine gamma-synthase activity
HVY73_RS03565	COG1811	Na channel or pump
HVY73_RS03570	COG1982	Orn Lys Arg decarboxylase major
HVY73_RS03575	COG2211	Major facilitator Superfamily
HVY73_RS03590	COG1194	a g-specific adenine glycosylase
HVY73_RS03600	COG3171	Protein conserved in bacteria
HVY73_RS03610	COG4214	carbohydrate transport
HVY73_RS03625	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HVY73_RS03640	COG0762	integral membrane protein
HVY73_RS03645	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HVY73_RS03650	COG2805	Type II/IV secretion system protein
HVY73_RS03670	COG0189	ligase activity
HVY73_RS03675	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HVY73_RS03680	COG2356	endonuclease I
HVY73_RS03690	COG2814	Major facilitator Superfamily
HVY73_RS03725	COG0501	Belongs to the peptidase M48B family
HVY73_RS03730	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HVY73_RS03745	COG0191	fructose-bisphosphate aldolase activity
HVY73_RS03750	COG0668	transmembrane transport
HVY73_RS03760	COG2968	Membrane
HVY73_RS03775	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HVY73_RS03780	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HVY73_RS03800	COG0006	proline dipeptidase activity
HVY73_RS03805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVY73_RS03810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVY73_RS03830	COG1028	Short-chain dehydrogenase reductase Sdr
HVY73_RS03835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HVY73_RS03855	COG2723	6-phospho-beta-galactosidase activity
HVY73_RS03860	COG1737	Transcriptional regulator
HVY73_RS03870	COG1272	protein, Hemolysin III
HVY73_RS03880	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HVY73_RS03890	COG0716	FMN binding
HVY73_RS03895	COG4974	Belongs to the 'phage' integrase family
HVY73_RS03905	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HVY73_RS03925	COG4942	peptidase
HVY73_RS03950	COG0667	Aldo Keto reductase
HVY73_RS03990	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HVY73_RS03995	COG1393	Belongs to the ArsC family
HVY73_RS04000	COG3104	oligopeptide transport
HVY73_RS04010	COG1538	Outer membrane efflux protein
HVY73_RS04015	COG1289	transmembrane transporter activity
HVY73_RS04030	COG3592	Divergent 4Fe-4S mono-cluster
HVY73_RS04035	COG2388	GCN5-related N-acetyl-transferase
HVY73_RS04045	COG3539	Fimbrial protein
HVY73_RS04050	COG3539	Fimbrial protein
HVY73_RS04055	COG3539	Fimbrial protein
HVY73_RS04060	COG3188	usher protein
HVY73_RS04065	COG3121	Chaperone
HVY73_RS04070	COG3539	Fimbrial protein
HVY73_RS04080	COG4974	Belongs to the 'phage' integrase family
HVY73_RS04085	COG0582	viral genome integration into host DNA
HVY73_RS04090	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HVY73_RS04095	COG1846	Transcriptional regulator
HVY73_RS04100	COG0697	spore germination
HVY73_RS04150	COG0667	Aldo Keto reductase
HVY73_RS04155	COG0814	amino acid
HVY73_RS04170	COG0183	Belongs to the thiolase family
HVY73_RS04180	COG0823	Involved in the tonB-independent uptake of proteins
HVY73_RS04185	COG1028	Short-chain dehydrogenase reductase Sdr
HVY73_RS04190	COG2814	Major facilitator Superfamily
HVY73_RS04225	COG3842	ATPase activity
HVY73_RS04230	COG0395	ABC-type sugar transport system, permease component
HVY73_RS04235	COG1175	transmembrane transport
HVY73_RS04240	COG1917	Cupin 2, conserved barrel domain protein
HVY73_RS04245	COG1794	racemase activity, acting on amino acids and derivatives
HVY73_RS04250	COG0583	DNA-binding transcription factor activity
HVY73_RS04260	COG1609	Transcriptional regulator
HVY73_RS04265	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVY73_RS04270	COG2723	6-phospho-beta-galactosidase activity
HVY73_RS04275	COG2186	Transcriptional regulator
HVY73_RS04285	COG1609	Transcriptional regulator
HVY73_RS04300	COG0667	Aldo Keto reductase
HVY73_RS04310	COG0861	Integral membrane protein TerC family
HVY73_RS04345	COG2165	general secretion pathway protein
HVY73_RS04350	COG4795	General secretion pathway protein
HVY73_RS04360	COG4967	type IV pilus modification protein PilV
HVY73_RS04365	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HVY73_RS04370	COG1025	Belongs to the peptidase M16 family
HVY73_RS04375	COG1074	ATP-dependent DNA helicase activity
HVY73_RS04380	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HVY73_RS04390	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HVY73_RS04390	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HVY73_RS04395	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVY73_RS04400	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HVY73_RS04430	COG4656	Part of a membrane complex involved in electron transport
HVY73_RS04435	COG1454	alcohol dehydrogenase
HVY73_RS04435	COG1012	belongs to the aldehyde dehydrogenase family
HVY73_RS04630	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HVY73_RS04635	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HVY73_RS04640	COG2166	iron-sulfur cluster assembly
HVY73_RS04645	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HVY73_RS04655	COG0583	DNA-binding transcription factor activity
HVY73_RS04660	COG2363	Small membrane protein
HVY73_RS04670	COG1349	DNA-binding transcription factor activity
HVY73_RS04690	COG0738	Major facilitator superfamily
HVY73_RS04695	COG0235	Class ii aldolase
HVY73_RS04700	COG1454	alcohol dehydrogenase
HVY73_RS04720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HVY73_RS04735	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HVY73_RS04740	COG2011	ABC-type metal ion transport system permease component
HVY73_RS04745	COG1464	Belongs to the NlpA lipoprotein family
HVY73_RS04750	COG0477	Major facilitator Superfamily
HVY73_RS04760	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HVY73_RS04765	COG1760	l-serine dehydratase
HVY73_RS04770	COG0814	amino acid
HVY73_RS04775	COG1611	Belongs to the LOG family
HVY73_RS04790	COG3098	single-species biofilm formation
HVY73_RS04795	COG0564	pseudouridine synthase activity
HVY73_RS04800	COG0716	FMN binding
HVY73_RS04805	COG2271	Major facilitator Superfamily
HVY73_RS04810	COG4948	Mandelate Racemase Muconate Lactonizing
HVY73_RS04815	COG4948	Mandelate Racemase Muconate Lactonizing
HVY73_RS04820	COG1929	Belongs to the glycerate kinase type-1 family
HVY73_RS04825	COG2205	protein histidine kinase activity
HVY73_RS04825	COG3437	response regulator, receiver
HVY73_RS04825	COG4999	Histidine kinase
HVY73_RS04825	COG3850	Histidine kinase
HVY73_RS04835	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HVY73_RS04840	COG3956	TIGRFAM MazG family protein
HVY73_RS04860	COG0602	queuosine metabolic process
HVY73_RS04865	COG0720	synthase
HVY73_RS04885	COG2234	aminopeptidase activity
HVY73_RS04945	COG1388	LysM domain
HVY73_RS04945	COG4942	peptidase
HVY73_RS04950	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HVY73_RS04975	COG0163	prenyltransferase activity
HVY73_RS04980	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HVY73_RS05020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY73_RS05025	COG4558	Periplasmic binding protein
HVY73_RS05030	COG3720	iron ion transport
HVY73_RS05050	COG0679	Auxin Efflux Carrier
HVY73_RS05065	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HVY73_RS05070	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HVY73_RS05075	COG1121	(ABC) transporter
HVY73_RS05085	COG1609	Transcriptional regulator
HVY73_RS05090	COG1940	carbohydrate kinase activity
HVY73_RS05095	COG1447	Phosphotransferase system cellobiose-specific component IIA
HVY73_RS05100	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVY73_RS05105	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVY73_RS05110	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVY73_RS05115	COG4580	involved in the transport of maltose and maltodextrins
HVY73_RS05125	COG2723	6-phospho-beta-galactosidase activity
HVY73_RS05135	COG0309	Hydrogenase expression formation protein (HypE)
HVY73_RS05140	COG0409	Hydrogenase expression formation protein
HVY73_RS05145	COG0298	carbon dioxide binding
HVY73_RS05150	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HVY73_RS05165	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY73_RS05170	COG0651	ATP synthesis coupled electron transport
HVY73_RS05175	COG0650	Formate hydrogenlyase subunit 4
HVY73_RS05180	COG3261	NADH dehydrogenase
HVY73_RS05180	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HVY73_RS05185	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVY73_RS05190	COG3260	NADH ubiquinone oxidoreductase 20
HVY73_RS05200	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HVY73_RS05210	COG2723	6-phospho-beta-galactosidase activity
HVY73_RS05215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY73_RS05215	COG1263	PTS System
HVY73_RS05220	COG1609	Transcriptional regulator
HVY73_RS05225	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY73_RS05230	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HVY73_RS05235	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HVY73_RS05260	COG1349	DNA-binding transcription factor activity
HVY73_RS05265	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY73_RS05270	COG1028	Short-chain dehydrogenase reductase Sdr
HVY73_RS05280	COG3732	PTS system glucitol sorbitol-specific
HVY73_RS05285	COG3730	PTS system glucitol sorbitol-specific
HVY73_RS05290	COG2951	lytic endotransglycosylase activity
HVY73_RS05295	COG1121	(ABC) transporter
HVY73_RS05300	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HVY73_RS05305	COG0803	Belongs to the bacterial solute-binding protein 9 family
HVY73_RS05310	COG1546	Belongs to the CinA family
HVY73_RS05330	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HVY73_RS05360	COG2823	Periplasmic or secreted lipoprotein
HVY73_RS05365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVY73_RS05370	COG1238	metal cluster binding
HVY73_RS05390	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HVY73_RS05395	COG2814	Major facilitator Superfamily
HVY73_RS05400	COG1566	PFAM secretion protein HlyD family protein
HVY73_RS05405	COG1846	Transcriptional regulator
HVY73_RS05415	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HVY73_RS05425	COG4176	ABC-type proline glycine betaine transport system permease component
HVY73_RS05440	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVY73_RS05450	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HVY73_RS05455	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVY73_RS05460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HVY73_RS05465	COG4575	ribosome binding
HVY73_RS05480	COG2916	Histone family protein nucleoid-structuring protein H-NS
HVY73_RS05495	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HVY73_RS05500	COG0640	Transcriptional regulator
HVY73_RS05510	COG0583	DNA-binding transcription factor activity
HVY73_RS05515	COG3284	Transcriptional regulator
HVY73_RS05520	COG1012	belongs to the aldehyde dehydrogenase family
HVY73_RS05525	COG3539	Fimbrial protein
HVY73_RS05530	COG3121	Chaperone
HVY73_RS05565	COG1028	Short-chain dehydrogenase reductase Sdr
HVY73_RS05575	COG0235	Class ii aldolase
HVY73_RS05585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY73_RS05620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY73_RS05625	COG3708	Transcriptional regulator
HVY73_RS05625	COG2207	Transcriptional regulator
HVY73_RS05655	COG2003	Belongs to the UPF0758 family
HVY73_RS05715	COG3311	Transcriptional regulator
HVY73_RS05725	COG0582	viral genome integration into host DNA
HVY73_RS05740	COG2867	negative regulation of translational initiation
HVY73_RS05755	COG0497	DNA recombination
HVY73_RS05770	COG4536	flavin adenine dinucleotide binding
HVY73_RS05775	COG4137	Cytochrome C assembly protein
HVY73_RS05780	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HVY73_RS05815	COG2885	chlorophyll binding
HVY73_RS05820	COG2199	diguanylate cyclase activity
HVY73_RS05830	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HVY73_RS05835	COG1605	Chorismate mutase
HVY73_RS05835	COG0287	Prephenate dehydrogenase
HVY73_RS05845	COG0077	Prephenate dehydratase
HVY73_RS05845	COG1605	Chorismate mutase
HVY73_RS05855	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HVY73_RS05860	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVY73_RS05875	COG0542	response to heat
HVY73_RS05900	COG0477	Major facilitator Superfamily
HVY73_RS05905	COG5544	Lipoprotein
HVY73_RS05910	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVY73_RS05925	COG3118	belongs to the thioredoxin family
HVY73_RS05930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVY73_RS05945	COG0513	Belongs to the DEAD box helicase family
HVY73_RS05955	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HVY73_RS05970	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HVY73_RS05975	COG3026	antisigma factor binding
HVY73_RS05980	COG3086	response to oxidative stress
HVY73_RS05990	COG0681	Belongs to the peptidase S26 family
HVY73_RS06010	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HVY73_RS06020	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY73_RS06025	COG1737	Transcriptional regulator
HVY73_RS06030	COG0560	Phosphoserine phosphatase
HVY73_RS06045	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HVY73_RS06045	COG0047	phosphoribosylformylglycinamidine synthase activity
HVY73_RS06050	COG2205	protein histidine kinase activity
HVY73_RS06055	COG3170	Tfp pilus assembly protein FimV
HVY73_RS06060	COG2204	response regulator
HVY73_RS06065	COG0347	Belongs to the P(II) protein family
HVY73_RS06070	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVY73_RS06070	COG1017	nitric oxide dioxygenase activity
HVY73_RS06080	COG2259	Doxx family
HVY73_RS06085	COG1940	carbohydrate kinase activity
HVY73_RS06090	COG0457	Tetratricopeptide repeat
HVY73_RS06095	COG0477	Major facilitator Superfamily
HVY73_RS06095	COG2814	Major facilitator Superfamily
HVY73_RS06100	COG2017	converts alpha-aldose to the beta-anomer
HVY73_RS06105	COG2814	Major facilitator Superfamily
HVY73_RS06110	COG3711	transcriptional antiterminator
HVY73_RS06115	COG3683	transport system, periplasmic component
HVY73_RS06120	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HVY73_RS06150	COG0822	iron-sulfur transferase activity
HVY73_RS06170	COG0633	Ferredoxin
HVY73_RS06175	COG2975	iron-sulfur cluster assembly
HVY73_RS06195	COG2897	thiosulfate sulfurtransferase activity
HVY73_RS06200	COG2373	Large extracellular alpha-helical protein
HVY73_RS06205	COG4953	penicillin-binding protein 1C
HVY73_RS06235	COG2976	Protein conserved in bacteria
HVY73_RS06255	COG1645	bacterial-type flagellum-dependent swarming motility
HVY73_RS06265	COG0517	IMP dehydrogenase activity
HVY73_RS06265	COG0516	GMP reductase activity
HVY73_RS06275	COG3119	arylsulfatase activity
HVY73_RS06280	COG0641	radical SAM
HVY73_RS06300	COG2200	EAL domain
HVY73_RS06315	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HVY73_RS06330	COG2723	6-phospho-beta-galactosidase activity
HVY73_RS06340	COG2233	PERMEase
HVY73_RS06355	COG1393	Belongs to the ArsC family
HVY73_RS06360	COG4783	chaperone-mediated protein folding
HVY73_RS06370	COG0628	permease
HVY73_RS06375	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HVY73_RS06380	COG2716	regulation of RNA biosynthetic process
HVY73_RS06390	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HVY73_RS06400	COG2321	neutral zinc metallopeptidase
HVY73_RS06405	COG1444	tRNA N-acetyltransferase activity
HVY73_RS06410	COG0400	carboxylic ester hydrolase activity
HVY73_RS06425	COG1393	Belongs to the ArsC family
HVY73_RS06435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVY73_RS06440	COG0493	'glutamate synthase
HVY73_RS06440	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY73_RS06450	COG5342	invasion associated locus B
HVY73_RS06455	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HVY73_RS06460	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVY73_RS06470	COG4810	utilization protein
HVY73_RS06560	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVY73_RS06580	COG2837	iron assimilation
HVY73_RS06590	COG4150	thiosulfate binding
HVY73_RS06595	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HVY73_RS06600	COG4208	sulfate ABC transporter
HVY73_RS06605	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HVY73_RS06615	COG4319	ketosteroid isomerase
HVY73_RS06650	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HVY73_RS06670	COG3530	Putative quorum-sensing-regulated virulence factor
HVY73_RS06675	COG0385	Bile acid
HVY73_RS06680	COG0583	DNA-binding transcription factor activity
HVY73_RS06715	COG3415	Transposase
HVY73_RS06720	COG3415	Transposase
HVY73_RS06735	COG2199	diguanylate cyclase activity
HVY73_RS06735	COG2200	EAL domain
HVY73_RS06740	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HVY73_RS06755	COG0667	Aldo Keto reductase
HVY73_RS06760	COG3961	Belongs to the TPP enzyme family
HVY73_RS06775	COG3279	Response regulator of the LytR AlgR family
HVY73_RS06780	COG3275	phosphorelay sensor kinase activity
HVY73_RS06795	COG0436	Aminotransferase
HVY73_RS06805	COG2807	transmembrane transport
HVY73_RS06810	COG0590	tRNA wobble adenosine to inosine editing
HVY73_RS06815	COG0583	DNA-binding transcription factor activity
HVY73_RS06865	COG4221	oxidoreductase activity
HVY73_RS06870	COG0583	DNA-binding transcription factor activity
HVY73_RS06875	COG1408	metallophosphoesterase
HVY73_RS06880	COG2814	Major facilitator Superfamily
HVY73_RS06885	COG1028	Short-chain dehydrogenase reductase Sdr
HVY73_RS06895	COG4221	oxidoreductase activity
HVY73_RS06990	COG3121	Chaperone
HVY73_RS06995	COG3188	usher protein
HVY73_RS07015	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HVY73_RS07035	COG2116	formate transmembrane transporter activity
HVY73_RS07040	COG2853	Lipoprotein
HVY73_RS07050	COG3691	Protein conserved in bacteria
HVY73_RS07065	COG2062	phosphohistidine phosphatase, SixA
HVY73_RS07090	COG0730	response to heat
HVY73_RS07095	COG3101	peptidyl-lysine hydroxylation
HVY73_RS07110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVY73_RS07130	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HVY73_RS07140	COG0586	Pfam SNARE associated Golgi protein
HVY73_RS07150	COG0285	dihydrofolate synthase activity
HVY73_RS07155	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HVY73_RS07160	COG1286	toxin biosynthetic process
HVY73_RS07165	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HVY73_RS07170	COG0163	prenyltransferase activity
HVY73_RS07195	COG4160	amino acid transport
HVY73_RS07200	COG4598	ABC transporter
HVY73_RS07215	COG1090	epimerase
HVY73_RS07220	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HVY73_RS07225	COG0625	glutathione transferase activity
HVY73_RS07230	COG0625	glutathione transferase activity
HVY73_RS07235	COG0622	Phosphoesterase
HVY73_RS07240	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HVY73_RS07245	COG0280	phosphate acetyltransferase
HVY73_RS07245	COG0857	belongs to the CobB CobQ family
HVY73_RS07265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVY73_RS07270	COG0471	metal ion transport
HVY73_RS07270	COG0490	domain, Protein
HVY73_RS07280	COG0436	Aminotransferase
HVY73_RS07285	COG0583	DNA-binding transcription factor activity
HVY73_RS07330	COG0839	Belongs to the complex I subunit 6 family
HVY73_RS07340	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HVY73_RS07345	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVY73_RS07360	COG2153	protein acetylation
HVY73_RS07365	COG1169	isochorismate synthase
HVY73_RS07390	COG0318	PFAM AMP-dependent synthetase and ligase
HVY73_RS07400	COG5464	transposase or invertase
HVY73_RS07415	COG1414	Transcriptional regulator
HVY73_RS07425	COG2271	Major facilitator Superfamily
HVY73_RS07435	COG0247	lactate metabolic process
HVY73_RS07445	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HVY73_RS07450	COG2271	Major facilitator Superfamily
HVY73_RS07455	COG0584	glycerophosphoryl diester phosphodiesterase
HVY73_RS07460	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVY73_RS07485	COG2205	protein histidine kinase activity
HVY73_RS07485	COG0784	Response regulator, receiver
HVY73_RS07495	COG2198	Histidine kinase
HVY73_RS07495	COG0642	Histidine kinase
HVY73_RS07510	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HVY73_RS07510	COG2169	Transcriptional regulator
HVY73_RS07515	COG3145	DNA-N1-methyladenine dioxygenase activity
HVY73_RS07520	COG4615	Cyclic peptide transporter
HVY73_RS07525	COG2239	Acts as a magnesium transporter
HVY73_RS07530	COG0659	secondary active sulfate transmembrane transporter activity
HVY73_RS07545	COG0628	permease
HVY73_RS07570	COG1349	DNA-binding transcription factor activity
HVY73_RS07575	COG0494	nUDIX hydrolase
HVY73_RS07595	COG1061	Type III restriction enzyme res subunit
HVY73_RS07600	COG1187	pseudouridine synthase activity
HVY73_RS07605	COG2814	Major facilitator Superfamily
HVY73_RS07615	COG4172	Belongs to the ABC transporter superfamily
HVY73_RS07620	COG4239	(ABC) transporter, permease
HVY73_RS07625	COG4174	ABC transporter (Permease)
HVY73_RS07630	COG4166	transmembrane transport
HVY73_RS07635	COG2200	EAL domain
HVY73_RS07640	COG0791	NLP P60 protein
HVY73_RS07645	COG0671	phosphoesterase, PA-phosphatase related
HVY73_RS07650	COG0523	cobalamin synthesis protein
HVY73_RS07655	COG0246	Mannitol dehydrogenase
HVY73_RS07660	COG1312	Catalyzes the dehydration of D-mannonate
HVY73_RS07675	COG2814	Major facilitator Superfamily
HVY73_RS07680	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY73_RS07680	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY73_RS07685	COG1105	Belongs to the carbohydrate kinase PfkB family
HVY73_RS07690	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HVY73_RS07690	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY73_RS07690	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY73_RS07700	COG2855	membrane
HVY73_RS07705	COG0583	DNA-binding transcription factor activity
HVY73_RS07710	COG0833	amino acid
HVY73_RS07715	COG4771	TonB-dependent receptor
HVY73_RS07730	COG2311	Membrane
HVY73_RS07745	COG1129	ABC transporter
HVY73_RS07755	COG2949	membrane
HVY73_RS07765	COG1346	cytolysis
HVY73_RS07775	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HVY73_RS07780	COG3659	wide pore channel activity
HVY73_RS07795	COG2723	6-phospho-beta-galactosidase activity
HVY73_RS07800	COG1538	Outer membrane efflux protein
HVY73_RS07805	COG0586	Pfam SNARE associated Golgi protein
HVY73_RS07815	COG1686	Belongs to the peptidase S11 family
HVY73_RS07825	COG0277	FAD linked oxidase domain protein
HVY73_RS07830	COG1472	Belongs to the glycosyl hydrolase 3 family
HVY73_RS07835	COG1732	Glycine betaine
HVY73_RS07840	COG1174	glycine betaine transport
HVY73_RS07845	COG1125	glycine betaine transport
HVY73_RS07850	COG1174	glycine betaine transport
HVY73_RS07860	COG3275	phosphorelay sensor kinase activity
HVY73_RS07870	COG4807	Protein conserved in bacteria
HVY73_RS07890	COG5455	response to cobalt ion
HVY73_RS07895	COG0583	DNA-binding transcription factor activity
HVY73_RS07900	COG2252	PERMEase
HVY73_RS07910	COG0583	DNA-binding transcription factor activity
HVY73_RS07925	COG0351	phosphomethylpyrimidine kinase
HVY73_RS07930	COG1830	Aldolase
HVY73_RS07940	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HVY73_RS07965	COG1070	Carbohydrate kinase
HVY73_RS07975	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVY73_RS07980	COG4948	Mandelate Racemase Muconate Lactonizing
HVY73_RS07985	COG0747	negative chemotaxis
HVY73_RS07990	COG0601	transmembrane transport
HVY73_RS08000	COG0444	Belongs to the ABC transporter superfamily
HVY73_RS08005	COG4608	Belongs to the ABC transporter superfamily
HVY73_RS08020	COG0745	RESPONSE REGULATOR receiver
HVY73_RS08025	COG2205	protein histidine kinase activity
HVY73_RS08050	COG1301	dicarboxylic acid transport
HVY73_RS08070	COG5002	protein histidine kinase activity
HVY73_RS08075	COG0443	Heat shock 70 kDa protein
HVY73_RS08080	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HVY73_RS08095	COG2982	Protein involved in outer membrane biogenesis
HVY73_RS08100	COG1253	flavin adenine dinucleotide binding
HVY73_RS08190	COG1088	dTDP-glucose 4,6-dehydratase activity
HVY73_RS08250	COG0438	transferase activity, transferring glycosyl groups
HVY73_RS08255	COG1215	transferase activity, transferring glycosyl groups
HVY73_RS08275	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HVY73_RS08305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVY73_RS08310	COG0583	DNA-binding transcription factor activity
HVY73_RS08320	COG0531	amino acid
HVY73_RS08325	COG0640	Transcriptional regulator
HVY73_RS08330	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HVY73_RS08335	COG2925	Exonuclease
HVY73_RS08350	COG1289	transmembrane transporter activity
HVY73_RS08370	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HVY73_RS08380	COG1942	4-Oxalocrotonate Tautomerase
HVY73_RS08385	COG0583	DNA-binding transcription factor activity
HVY73_RS08390	COG0095	Lipoate-protein ligase
HVY73_RS08395	COG0477	Major facilitator Superfamily
HVY73_RS08405	COG5001	Diguanylate cyclase
HVY73_RS08405	COG3300	MHYT domain
HVY73_RS08415	COG3615	Tellurite resistance protein tehB
HVY73_RS08440	COG3706	GGDEF domain
HVY73_RS08480	COG3423	Transcriptional regulator
HVY73_RS08500	COG0534	Mate efflux family protein
HVY73_RS08510	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HVY73_RS08530	COG0604	alcohol dehydrogenase
HVY73_RS08535	COG1309	transcriptional regulator
HVY73_RS08540	COG0025	NhaP-type Na H and K H
HVY73_RS08585	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVY73_RS08595	COG1418	mRNA catabolic process
HVY73_RS08600	COG0270	DNA (cytosine-5-)-methyltransferase activity
HVY73_RS08605	COG3727	T/G mismatch-specific endonuclease activity
HVY73_RS08610	COG0697	spore germination
HVY73_RS08615	COG2354	Protein conserved in bacteria
HVY73_RS08645	COG0366	Alpha amylase catalytic
HVY73_RS08670	COG2197	response regulator
HVY73_RS08680	COG2197	response regulator
HVY73_RS08715	COG3318	Belongs to the UPF0149 family
HVY73_RS08715	COG3012	SEC-C Motif Domain Protein
HVY73_RS08720	COG0814	amino acid
HVY73_RS08730	COG1528	Iron-storage protein
HVY73_RS08745	COG0477	Major facilitator Superfamily
HVY73_RS08755	COG2211	Major facilitator Superfamily
HVY73_RS08765	COG1528	Iron-storage protein
HVY73_RS08775	COG1879	ABC-type sugar transport system periplasmic component
HVY73_RS08785	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY73_RS08810	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HVY73_RS08820	COG3102	Protein conserved in bacteria
HVY73_RS08840	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HVY73_RS08845	COG1801	Protein of unknown function DUF72
HVY73_RS08850	COG1335	isochorismatase
HVY73_RS08860	COG0494	nUDIX hydrolase
HVY73_RS08885	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HVY73_RS08895	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HVY73_RS08900	COG0739	heme binding
HVY73_RS08905	COG1560	Kdo2-lipid A biosynthetic process
HVY73_RS08915	COG1737	Transcriptional regulator
HVY73_RS08925	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HVY73_RS08930	COG0129	dihydroxy-acid dehydratase activity
HVY73_RS08935	COG0800	Aldolase
HVY73_RS08945	COG3141	response to X-ray
HVY73_RS08950	COG2979	Protein of unknown function (DUF533)
HVY73_RS08955	COG1770	oligopeptidase
HVY73_RS08960	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVY73_RS08970	COG2372	response to copper ion
HVY73_RS08975	COG1276	copper resistance
HVY73_RS08990	COG2990	Protein conserved in bacteria
HVY73_RS09015	COG3008	intermembrane lipid transfer
HVY73_RS09020	COG2995	paraquat-inducible protein a
HVY73_RS09025	COG1956	GAF domain-containing protein
HVY73_RS09045	COG2814	Major facilitator Superfamily
HVY73_RS09050	COG1414	Transcriptional regulator
HVY73_RS09080	COG0768	penicillin binding
HVY73_RS09085	COG2226	methyltransferase
HVY73_RS09100	COG3716	PTS system mannose fructose sorbose family IID component
HVY73_RS09105	COG3715	PTS system
HVY73_RS09110	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY73_RS09110	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY73_RS09115	COG1253	flavin adenine dinucleotide binding
HVY73_RS09120	COG2200	EAL domain
HVY73_RS09125	COG1760	l-serine dehydratase
HVY73_RS09145	COG0251	oxidation-reduction process
HVY73_RS09150	COG1199	ATP-dependent helicase activity
HVY73_RS09160	COG3065	identical protein binding
HVY73_RS09170	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HVY73_RS09180	COG2894	cell division
HVY73_RS09195	COG0179	Fumarylacetoacetate (FAA) hydrolase
HVY73_RS09225	COG2719	SpoVR family
HVY73_RS09250	COG1619	proteins homologs of microcin C7 resistance protein MccF
HVY73_RS09260	COG4774	siderophore transport
HVY73_RS09275	COG2308	Evidence 4 Homologs of previously reported genes of
HVY73_RS09315	COG0583	DNA-binding transcription factor activity
HVY73_RS09320	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HVY73_RS09335	COG1882	Formate acetyltransferase
HVY73_RS09370	COG0583	DNA-binding transcription factor activity
HVY73_RS09400	COG0583	DNA-binding transcription factor activity
HVY73_RS09415	COG3122	Protein conserved in bacteria
HVY73_RS09435	COG2885	chlorophyll binding
HVY73_RS09445	COG3501	Rhs element vgr protein
HVY73_RS09500	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HVY73_RS09585	COG0012	GTP binding
HVY73_RS09605	COG0659	secondary active sulfate transmembrane transporter activity
HVY73_RS09635	COG2890	protein-(glutamine-N5) methyltransferase activity
HVY73_RS09655	COG0387	Pfam Sodium calcium exchanger
HVY73_RS09660	COG4572	Cation transport regulator
HVY73_RS09665	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HVY73_RS09675	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HVY73_RS09680	COG3707	response regulator
HVY73_RS09685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HVY73_RS09695	COG1116	anion transmembrane transporter activity
HVY73_RS09700	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HVY73_RS09700	COG2146	nitrite reductase [NAD(P)H] activity
HVY73_RS09705	COG0243	molybdopterin cofactor binding
HVY73_RS09710	COG4932	domain protein
HVY73_RS09715	COG2197	response regulator
HVY73_RS09720	COG3850	Histidine kinase
HVY73_RS09725	COG2223	nitrite transmembrane transporter activity
HVY73_RS09735	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HVY73_RS09740	COG1140	nitrate reductase beta subunit
HVY73_RS09745	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HVY73_RS09750	COG2181	nitrate reductase activity
HVY73_RS09760	COG1522	sequence-specific DNA binding
HVY73_RS09790	COG0788	formyltetrahydrofolate deformylase activity
HVY73_RS09800	COG1752	Esterase of the alpha-beta hydrolase superfamily
HVY73_RS09805	COG0745	RESPONSE REGULATOR receiver
HVY73_RS09810	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HVY73_RS09815	COG2916	Histone family protein nucleoid-structuring protein H-NS
HVY73_RS09825	COG1435	thymidine kinase activity
HVY73_RS09830	COG1012	belongs to the aldehyde dehydrogenase family
HVY73_RS09830	COG1454	alcohol dehydrogenase
HVY73_RS09840	COG2095	MarC family integral membrane protein
HVY73_RS09845	COG4166	transmembrane transport
HVY73_RS09850	COG0601	transmembrane transport
HVY73_RS09855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVY73_RS09860	COG0444	Belongs to the ABC transporter superfamily
HVY73_RS09870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVY73_RS09890	COG2353	YceI-like domain
HVY73_RS09900	COG2350	Protein conserved in bacteria
HVY73_RS09910	COG3001	Fructosamine kinase
HVY73_RS09920	COG1105	Belongs to the carbohydrate kinase PfkB family
HVY73_RS09925	COG3137	Salt-induced outer membrane protein
HVY73_RS09965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HVY73_RS09965	COG0072	phenylalanine-tRNA ligase activity
HVY73_RS09985	COG0583	DNA-binding transcription factor activity
HVY73_RS10005	COG0386	Belongs to the glutathione peroxidase family
HVY73_RS10015	COG0791	NLP P60 protein
HVY73_RS10025	COG4256	Hemin uptake protein
HVY73_RS10030	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HVY73_RS10045	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVY73_RS10045	COG0574	Belongs to the PEP-utilizing enzyme family
HVY73_RS10055	COG0628	permease
HVY73_RS10060	COG0247	lactate metabolic process
HVY73_RS10060	COG0277	FAD linked oxidase domain protein
HVY73_RS10065	COG2050	protein possibly involved in aromatic compounds catabolism
HVY73_RS10070	COG2261	transglycosylase associated protein
HVY73_RS10095	COG1120	ATPase activity
HVY73_RS10100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY73_RS10110	COG0583	DNA-binding transcription factor activity
HVY73_RS10135	COG1304	FMN binding
HVY73_RS10140	COG1309	transcriptional regulator
HVY73_RS10160	COG0316	Belongs to the HesB IscA family
HVY73_RS10165	COG0719	Fe-S assembly protein
HVY73_RS10170	COG0396	ATPase activity
HVY73_RS10175	COG0719	Fe-S assembly protein
HVY73_RS10190	COG1376	ErfK ybiS ycfS ynhG family protein
HVY73_RS10220	COG1309	transcriptional regulator
HVY73_RS10230	COG2271	Major facilitator Superfamily
HVY73_RS10235	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HVY73_RS10260	COG1414	Transcriptional regulator
HVY73_RS10295	COG2814	Major facilitator Superfamily
HVY73_RS10315	COG0583	DNA-binding transcription factor activity
HVY73_RS10320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HVY73_RS10340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HVY73_RS10345	COG1116	anion transmembrane transporter activity
HVY73_RS10350	COG4774	siderophore transport
HVY73_RS10355	COG1120	ATPase activity
HVY73_RS10360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY73_RS10365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY73_RS10385	COG0765	amino acid transport
HVY73_RS10390	COG1126	abc transporter atp-binding protein
HVY73_RS10460	COG3383	formate dehydrogenase (NAD+) activity
HVY73_RS10465	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HVY73_RS10475	COG1175	transmembrane transport
HVY73_RS10505	COG4133	protoheme IX ABC transporter activity
HVY73_RS10510	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HVY73_RS10515	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HVY73_RS10530	COG1138	Cytochrome C-type biogenesis protein
HVY73_RS10535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HVY73_RS10540	COG3088	subunit of a heme lyase
HVY73_RS10540	COG4235	cytochrome complex assembly
HVY73_RS10560	COG3850	Histidine kinase
HVY73_RS10560	COG5002	protein histidine kinase activity
HVY73_RS10565	COG0745	RESPONSE REGULATOR receiver
HVY73_RS10580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVY73_RS10610	COG1028	Short-chain dehydrogenase reductase Sdr
HVY73_RS10615	COG2610	gluconate transmembrane transporter activity
HVY73_RS10620	COG1250	3-hydroxyacyl-CoA dehydrogenase
HVY73_RS10630	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HVY73_RS10640	COG0583	DNA-binding transcription factor activity
HVY73_RS10660	COG0277	FAD linked oxidase domain protein
HVY73_RS10665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HVY73_RS10690	COG0402	S-adenosylhomocysteine deaminase activity
HVY73_RS10745	COG4608	Belongs to the ABC transporter superfamily
HVY73_RS10750	COG0444	Belongs to the ABC transporter superfamily
HVY73_RS10775	COG0346	lactoylglutathione lyase activity
HVY73_RS10780	COG1349	DNA-binding transcription factor activity
HVY73_RS10815	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HVY73_RS10870	COG0307	riboflavin synthase, alpha
HVY73_RS10875	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HVY73_RS10880	COG2814	Major facilitator Superfamily
HVY73_RS10885	COG0583	DNA-binding transcription factor activity
HVY73_RS10900	COG2814	Major facilitator Superfamily
HVY73_RS10915	COG0791	NLP P60 protein
HVY73_RS10920	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HVY73_RS10930	COG0346	lactoylglutathione lyase activity
HVY73_RS10935	COG1902	pentaerythritol trinitrate reductase activity
HVY73_RS10940	COG1309	transcriptional regulator
HVY73_RS10945	COG3313	Fe-S protein
HVY73_RS10950	COG4989	oxidoreductase activity
HVY73_RS10955	COG2032	superoxide dismutase activity
HVY73_RS10960	COG1289	transmembrane transporter activity
HVY73_RS10965	COG1566	PFAM secretion protein HlyD family protein
HVY73_RS10980	COG3706	GGDEF domain
HVY73_RS10995	COG3895	Periplasmic Protein
HVY73_RS11010	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HVY73_RS11015	COG0625	glutathione transferase activity
HVY73_RS11025	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HVY73_RS11035	COG4659	FMN binding
HVY73_RS11070	COG2723	6-phospho-beta-galactosidase activity
HVY73_RS11080	COG0673	inositol 2-dehydrogenase activity
HVY73_RS11090	COG2814	Major facilitator Superfamily
HVY73_RS11110	COG3038	cytochrome b561
HVY73_RS11130	COG0583	DNA-binding transcription factor activity
HVY73_RS11135	COG3485	protocatechuate 3,4-dioxygenase
HVY73_RS11140	COG3485	protocatechuate 3,4-dioxygenase
HVY73_RS11145	COG5383	Protein conserved in bacteria
HVY73_RS11150	COG2272	Belongs to the type-B carboxylesterase lipase family
HVY73_RS11165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVY73_RS11170	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HVY73_RS11175	COG1275	C4-dicarboxylate transporter malic acid transport protein
HVY73_RS11180	COG0500	methyltransferase
HVY73_RS11190	COG0697	spore germination
HVY73_RS11195	COG3708	Transcriptional regulator
HVY73_RS11195	COG2207	Transcriptional regulator
HVY73_RS11200	COG3135	benzoate transporter
HVY73_RS11205	COG1396	sequence-specific DNA binding
HVY73_RS11215	COG0826	peptidase U32
HVY73_RS11235	COG1294	oxidase, subunit
HVY73_RS11240	COG1271	oxidase subunit
HVY73_RS11245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HVY73_RS11250	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HVY73_RS11255	COG3842	ATPase activity
HVY73_RS11260	COG1176	ABC-type spermidine putrescine transport system, permease component I
HVY73_RS11265	COG1177	transmembrane transport
HVY73_RS11270	COG1012	belongs to the aldehyde dehydrogenase family
HVY73_RS11305	COG1012	belongs to the aldehyde dehydrogenase family
HVY73_RS11310	COG0747	negative chemotaxis
HVY73_RS11320	COG3238	Protein conserved in bacteria
HVY73_RS11325	COG1247	-acetyltransferase
HVY73_RS11335	COG2130	NADP-dependent
HVY73_RS11350	COG3691	Protein conserved in bacteria
HVY73_RS11355	COG1228	amidohydrolase
HVY73_RS11360	COG4772	TonB-dependent receptor
HVY73_RS11385	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HVY73_RS11390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HVY73_RS11395	COG1473	amidohydrolase
HVY73_RS11400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HVY73_RS11415	COG0765	amino acid transport
HVY73_RS11420	COG1126	abc transporter atp-binding protein
HVY73_RS11430	COG2271	Major facilitator Superfamily
HVY73_RS11440	COG1609	Transcriptional regulator
HVY73_RS11445	COG0625	glutathione transferase activity
HVY73_RS11470	COG2211	Major facilitator Superfamily
HVY73_RS11485	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HVY73_RS11490	COG3842	ATPase activity
HVY73_RS11495	COG1840	ABC-type Fe3 transport system, periplasmic component
HVY73_RS11500	COG1178	ABC-type Fe3 transport system permease component
HVY73_RS11505	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HVY73_RS11510	COG2181	nitrate reductase activity
HVY73_RS11515	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HVY73_RS11520	COG1140	nitrate reductase beta subunit
HVY73_RS11525	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HVY73_RS11545	COG1414	Transcriptional regulator
HVY73_RS11550	COG4948	Mandelate Racemase Muconate Lactonizing
HVY73_RS11555	COG4829	muconolactone delta-isomerase
HVY73_RS11560	COG3485	protocatechuate 3,4-dioxygenase
HVY73_RS11570	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HVY73_RS11595	COG0437	4 iron, 4 sulfur cluster binding
HVY73_RS11600	COG2864	formate dehydrogenase
HVY73_RS11615	COG2326	polyphosphate kinase activity
HVY73_RS11625	COG2814	Major facilitator Superfamily
HVY73_RS11635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HVY73_RS11655	COG0747	negative chemotaxis
HVY73_RS11660	COG1064	alcohol dehydrogenase
HVY73_RS11675	COG0488	(ABC) transporter
HVY73_RS11720	COG1028	Short-chain dehydrogenase reductase Sdr
HVY73_RS11725	COG3729	General stress protein
HVY73_RS11735	COG3685	Protein conserved in bacteria
HVY73_RS11745	COG0366	Alpha amylase catalytic
HVY73_RS11755	COG2323	membrane
HVY73_RS11765	COG3111	PFAM Bacterial OB fold (BOF) protein
HVY73_RS11775	COG1764	response to oxidative stress
HVY73_RS11800	COG3781	membrane
HVY73_RS11805	COG0243	molybdopterin cofactor binding
HVY73_RS11810	COG0583	DNA-binding transcription factor activity
HVY73_RS11815	COG2814	Major facilitator Superfamily
HVY73_RS11820	COG1285	pathogenesis
HVY73_RS11825	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HVY73_RS11835	COG0583	DNA-binding transcription factor activity
HVY73_RS11855	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HVY73_RS11855	COG0519	Catalyzes the synthesis of GMP from XMP
HVY73_RS11895	COG0596	Alpha beta hydrolase
HVY73_RS11900	COG0745	RESPONSE REGULATOR receiver
HVY73_RS11905	COG2205	protein histidine kinase activity
HVY73_RS11920	COG0076	glutamate decarboxylase activity
HVY73_RS11925	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HVY73_RS11930	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HVY73_RS11935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HVY73_RS11940	COG1116	anion transmembrane transporter activity
HVY73_RS11945	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HVY73_RS11960	COG0673	inositol 2-dehydrogenase activity
HVY73_RS11970	COG1609	Transcriptional regulator
HVY73_RS11975	COG3706	GGDEF domain
HVY73_RS11980	COG0402	S-adenosylhomocysteine deaminase activity
HVY73_RS11985	COG1953	Uracil, thiamine, allantoin
HVY73_RS12025	COG0406	alpha-ribazole phosphatase activity
HVY73_RS12045	COG2207	Transcriptional regulator
HVY73_RS12060	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVY73_RS12140	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HVY73_RS12155	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HVY73_RS12160	COG0583	DNA-binding transcription factor activity
HVY73_RS12170	COG1902	pentaerythritol trinitrate reductase activity
HVY73_RS12210	COG1902	pentaerythritol trinitrate reductase activity
HVY73_RS12215	COG4529	Protein conserved in bacteria
HVY73_RS12220	COG0477	Major facilitator Superfamily
HVY73_RS12250	COG2223	nitrite transmembrane transporter activity
HVY73_RS12260	COG1609	Transcriptional regulator
HVY73_RS12265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY73_RS12275	COG3037	sugar-specific permease SgaT UlaA
HVY73_RS12280	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HVY73_RS12290	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY73_RS12305	COG1652	LysM domain
HVY73_RS12330	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HVY73_RS12330	COG0456	acetyltransferase
HVY73_RS12345	COG3386	PFAM SMP-30 Gluconolaconase
HVY73_RS12370	COG4977	sequence-specific DNA binding
HVY73_RS12390	COG4977	sequence-specific DNA binding
HVY73_RS12410	COG1349	DNA-binding transcription factor activity
HVY73_RS12415	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HVY73_RS12420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY73_RS12425	COG0738	Major facilitator superfamily
HVY73_RS12470	COG1929	Belongs to the glycerate kinase type-1 family
HVY73_RS12475	COG3835	regulator
HVY73_RS12485	COG0583	DNA-binding transcription factor activity
HVY73_RS12495	COG2186	Transcriptional regulator
HVY73_RS12500	COG1263	PTS System
HVY73_RS12500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY73_RS12510	COG2814	Major facilitator Superfamily
HVY73_RS12515	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY73_RS12515	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY73_RS12530	COG2819	hydrolase of the alpha beta superfamily
HVY73_RS12535	COG5001	Diguanylate cyclase
HVY73_RS12535	COG3300	MHYT domain
HVY73_RS12570	COG3188	usher protein
HVY73_RS12585	COG3550	peptidyl-serine autophosphorylation
HVY73_RS12590	COG1396	sequence-specific DNA binding
HVY73_RS12595	COG2351	hydroxyisourate hydrolase activity
HVY73_RS12600	COG3195	allantoin biosynthetic process
HVY73_RS12600	COG3648	Uricase
HVY73_RS12605	COG2233	PERMEase
HVY73_RS12635	COG2207	Transcriptional regulator
HVY73_RS12650	COG4628	conserved protein (DUF2132)
HVY73_RS12670	COG2011	ABC-type metal ion transport system permease component
HVY73_RS12675	COG2070	2-Nitropropane dioxygenase
HVY73_RS12685	COG0477	Major facilitator Superfamily
HVY73_RS12735	COG2199	diguanylate cyclase activity
HVY73_RS12750	COG1012	belongs to the aldehyde dehydrogenase family
HVY73_RS12755	COG0583	DNA-binding transcription factor activity
HVY73_RS12765	COG0039	L-malate dehydrogenase activity
HVY73_RS12770	COG1349	DNA-binding transcription factor activity
HVY73_RS12775	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HVY73_RS12780	COG3395	kinase activity
HVY73_RS12790	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HVY73_RS12795	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HVY73_RS12800	COG2271	Major facilitator Superfamily
HVY73_RS12830	COG4977	sequence-specific DNA binding
HVY73_RS12840	COG0697	spore germination
HVY73_RS12845	COG2814	Major facilitator Superfamily
HVY73_RS12880	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HVY73_RS12915	COG2223	nitrite transmembrane transporter activity
HVY73_RS12920	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HVY73_RS12935	COG1349	DNA-binding transcription factor activity
HVY73_RS12940	COG2084	Dehydrogenase
HVY73_RS12945	COG3395	kinase activity
HVY73_RS12950	COG0235	Class ii aldolase
HVY73_RS12955	COG3622	Belongs to the hyi family
HVY73_RS12960	COG2610	gluconate transmembrane transporter activity
HVY73_RS12965	COG2207	Transcriptional regulator
HVY73_RS12965	COG3708	Transcriptional regulator
HVY73_RS12980	COG2200	EAL domain
HVY73_RS12985	COG1546	Belongs to the CinA family
HVY73_RS12990	COG0071	Belongs to the small heat shock protein (HSP20) family
HVY73_RS13020	COG2135	peptidase activity
HVY73_RS13025	COG2207	Transcriptional regulator
HVY73_RS13040	COG4221	oxidoreductase activity
HVY73_RS13045	COG1802	Transcriptional regulator
HVY73_RS13050	COG0589	response to stress
HVY73_RS13055	COG0246	Mannitol dehydrogenase
HVY73_RS13060	COG2271	Major facilitator Superfamily
HVY73_RS13075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVY73_RS13090	COG0243	molybdopterin cofactor binding
HVY73_RS13095	COG0437	4 iron, 4 sulfur cluster binding
HVY73_RS13100	COG3302	dmso reductase anchor subunit
HVY73_RS13115	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HVY73_RS13120	COG1940	carbohydrate kinase activity
HVY73_RS13125	COG0583	DNA-binding transcription factor activity
HVY73_RS13130	COG2814	Major facilitator Superfamily
HVY73_RS13135	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HVY73_RS13145	COG3591	Belongs to the peptidase S1B family
HVY73_RS13165	COG0628	permease
HVY73_RS13195	COG0679	Auxin Efflux Carrier
HVY73_RS13205	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HVY73_RS13240	COG3290	protein histidine kinase activity
HVY73_RS13245	COG4565	transcriptional regulatory protein
HVY73_RS13265	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY73_RS13265	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY73_RS13275	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVY73_RS13280	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HVY73_RS13290	COG0183	Belongs to the thiolase family
HVY73_RS13295	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HVY73_RS13305	COG1414	Transcriptional regulator
HVY73_RS13310	COG2840	Smr protein MutS2
HVY73_RS13315	COG0583	DNA-binding transcription factor activity
HVY73_RS13325	COG1473	amidohydrolase
HVY73_RS13330	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HVY73_RS13345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVY73_RS13360	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HVY73_RS13365	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HVY73_RS13380	COG0531	amino acid
HVY73_RS13390	COG3136	membrane protein required for alginate biosynthesis
HVY73_RS13395	COG0745	RESPONSE REGULATOR receiver
HVY73_RS13405	COG2205	protein histidine kinase activity
HVY73_RS13415	COG0114	fumarate hydratase activity
HVY73_RS13420	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY73_RS13420	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY73_RS13425	COG1482	cell wall glycoprotein biosynthetic process
HVY73_RS13430	COG5339	Protein conserved in bacteria
HVY73_RS13435	COG1609	Transcriptional regulator
HVY73_RS13440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY73_RS13440	COG1263	PTS System
HVY73_RS13445	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HVY73_RS13470	COG2391	methyltransferase activity
HVY73_RS13475	COG0425	Belongs to the sulfur carrier protein TusA family
HVY73_RS13480	COG5562	phage envelope protein
HVY73_RS13485	COG0401	homolog of Blt101
HVY73_RS13490	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HVY73_RS13495	COG1012	belongs to the aldehyde dehydrogenase family
HVY73_RS13505	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HVY73_RS13510	COG0477	Major facilitator Superfamily
HVY73_RS13515	COG1113	amino acid transport
HVY73_RS13520	COG2988	succinylglutamate desuccinylase activity
HVY73_RS13525	COG3724	N-succinylarginine dihydrolase activity
HVY73_RS13530	COG1012	belongs to the aldehyde dehydrogenase family
HVY73_RS13535	COG3138	arginine N-succinyltransferase
HVY73_RS13540	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HVY73_RS13550	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HVY73_RS13555	COG0667	Aldo Keto reductase
HVY73_RS13560	COG0583	DNA-binding transcription factor activity
HVY73_RS13585	COG4122	O-methyltransferase activity
HVY73_RS13590	COG1643	Atp-dependent helicase
HVY73_RS13605	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HVY73_RS13610	COG3327	negative regulation of DNA-templated transcription, initiation
HVY73_RS13615	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HVY73_RS13620	COG0183	Belongs to the thiolase family
HVY73_RS13625	COG2050	protein possibly involved in aromatic compounds catabolism
HVY73_RS13630	COG1250	3-hydroxyacyl-CoA dehydrogenase
HVY73_RS13635	COG1024	Enoyl-CoA hydratase
HVY73_RS13640	COG1024	Enoyl-CoA hydratase
HVY73_RS13645	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVY73_RS13650	COG2151	metal-sulfur cluster biosynthetic enzyme
HVY73_RS13655	COG3396	Phenylacetate-CoA oxygenase
HVY73_RS13660	COG3460	Phenylacetate-CoA oxygenase
HVY73_RS13665	COG3396	Phenylacetate-CoA oxygenase
HVY73_RS13670	COG2030	dehydratase
HVY73_RS13670	COG1012	belongs to the aldehyde dehydrogenase family
HVY73_RS13690	COG1012	belongs to the aldehyde dehydrogenase family
HVY73_RS13695	COG2207	Transcriptional regulator
HVY73_RS13700	COG3784	Protein of unknown function (DUF1318)
HVY73_RS13710	COG2911	Protein conserved in bacteria
HVY73_RS13715	COG0586	Pfam SNARE associated Golgi protein
HVY73_RS13720	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HVY73_RS13725	COG3187	Heat shock protein
HVY73_RS13730	COG3042	response to heat
HVY73_RS13735	COG0674	pyruvate-flavodoxin oxidoreductase activity
HVY73_RS13735	COG1013	pyruvate-flavodoxin oxidoreductase activity
HVY73_RS13735	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HVY73_RS13735	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVY73_RS13740	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVY73_RS13750	COG0589	response to stress
HVY73_RS13760	COG0513	Belongs to the DEAD box helicase family
HVY73_RS13770	COG1349	DNA-binding transcription factor activity
HVY73_RS13775	COG0673	inositol 2-dehydrogenase activity
HVY73_RS13790	COG1113	amino acid transport
HVY73_RS13795	COG1522	sequence-specific DNA binding
HVY73_RS13805	COG1448	Aminotransferase
HVY73_RS13810	COG2011	ABC-type metal ion transport system permease component
HVY73_RS13825	COG0436	Aminotransferase
HVY73_RS13830	COG0604	alcohol dehydrogenase
HVY73_RS13860	COG0583	DNA-binding transcription factor activity
HVY73_RS13880	COG1028	Short-chain dehydrogenase reductase Sdr
HVY73_RS13885	COG1309	transcriptional regulator
HVY73_RS13890	COG1028	Short-chain dehydrogenase reductase Sdr
HVY73_RS14005	COG2885	chlorophyll binding
HVY73_RS14030	COG0693	protein deglycase activity
HVY73_RS14035	COG1078	dGTPase activity
HVY73_RS14040	COG1028	Short-chain dehydrogenase reductase Sdr
HVY73_RS14045	COG0583	DNA-binding transcription factor activity
HVY73_RS14060	COG0656	L-ascorbic acid biosynthetic process
HVY73_RS14090	COG4166	transmembrane transport
HVY73_RS14100	COG2866	Carboxypeptidase
HVY73_RS14105	COG4948	Mandelate Racemase Muconate Lactonizing
HVY73_RS14110	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HVY73_RS14115	COG3180	Ammonia monooxygenase
HVY73_RS14125	COG1486	melibiose metabolic process
HVY73_RS14130	COG0583	DNA-binding transcription factor activity
HVY73_RS14140	COG3106	COG3106 Predicted ATPase
HVY73_RS14150	COG1983	PspC domain protein
HVY73_RS14160	COG1842	Phage shock protein A
HVY73_RS14165	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HVY73_RS14175	COG1473	amidohydrolase
HVY73_RS14190	COG0702	epimerase
HVY73_RS14205	COG4171	peptide transport system, permease
HVY73_RS14220	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HVY73_RS14230	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HVY73_RS14235	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVY73_RS14235	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVY73_RS14250	COG1349	DNA-binding transcription factor activity
HVY73_RS14260	COG0023	Translation Initiation Factor
HVY73_RS14270	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HVY73_RS14275	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HVY73_RS14280	COG0671	phosphoesterase, PA-phosphatase related
HVY73_RS14290	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HVY73_RS14315	COG0616	signal peptide processing
HVY73_RS14325	COG1028	Short-chain dehydrogenase reductase Sdr
HVY73_RS14330	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HVY73_RS14355	COG0583	DNA-binding transcription factor activity
HVY73_RS14365	COG0009	L-threonylcarbamoyladenylate synthase
HVY73_RS14375	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HVY73_RS14380	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HVY73_RS14380	COG0512	Glutamine amidotransferase of anthranilate synthase
HVY73_RS14385	COG0134	indole-3-glycerol-phosphate synthase activity
HVY73_RS14385	COG0135	phosphoribosylanthranilate isomerase activity
HVY73_RS14415	COG4774	siderophore transport
HVY73_RS14425	COG3047	cAMP biosynthetic process
HVY73_RS14430	COG0727	PFAM Uncharacterised protein family (UPF0153)
HVY73_RS14460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVY73_RS14465	COG1028	Short-chain dehydrogenase reductase Sdr
HVY73_RS14470	COG1988	membrane-bound metal-dependent
HVY73_RS14485	COG0753	catalase activity
HVY73_RS14495	COG1486	melibiose metabolic process
HVY73_RS14500	COG1917	Cupin 2, conserved barrel domain protein
HVY73_RS14500	COG2169	Transcriptional regulator
HVY73_RS14505	COG1447	Phosphotransferase system cellobiose-specific component IIA
HVY73_RS14510	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVY73_RS14520	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVY73_RS14525	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVY73_RS14535	COG0322	excinuclease ABC activity
HVY73_RS14540	COG3678	ATP-independent chaperone mediated protein folding
HVY73_RS14550	COG3724	N-succinylarginine dihydrolase activity
HVY73_RS14560	COG3138	arginine N-succinyltransferase
HVY73_RS14570	COG0708	Exodeoxyribonuclease III
HVY73_RS14575	COG0398	Pfam SNARE associated Golgi protein
HVY73_RS14580	COG0398	Pfam SNARE associated Golgi protein
HVY73_RS14585	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVY73_RS14590	COG4134	Bacterial extracellular solute-binding protein
HVY73_RS14595	COG4135	transport system, permease component
HVY73_RS14600	COG4136	ATPase activity
HVY73_RS14605	COG2897	thiosulfate sulfurtransferase activity
HVY73_RS14610	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HVY73_RS14615	COG0494	nUDIX hydrolase
HVY73_RS14620	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HVY73_RS14625	COG1028	Short-chain dehydrogenase reductase Sdr
HVY73_RS14625	COG0604	alcohol dehydrogenase
HVY73_RS14625	COG3321	synthase
HVY73_RS14630	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HVY73_RS14635	COG0709	Synthesizes selenophosphate from selenide and ATP
HVY73_RS14645	COG0778	Nitroreductase
HVY73_RS14650	COG0616	signal peptide processing
HVY73_RS14655	COG0252	asparaginase activity
HVY73_RS14660	COG1335	isochorismatase
HVY73_RS14665	COG2814	Major facilitator Superfamily
HVY73_RS14670	COG1349	DNA-binding transcription factor activity
HVY73_RS14675	COG0667	Aldo Keto reductase
HVY73_RS14680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY73_RS14685	COG0191	fructose-bisphosphate aldolase activity
HVY73_RS14690	COG1063	alcohol dehydrogenase
HVY73_RS14695	COG2271	Major facilitator Superfamily
HVY73_RS14700	COG1063	alcohol dehydrogenase
HVY73_RS14715	COG3139	Protein of unknown function (DUF1315)
HVY73_RS14735	COG0656	L-ascorbic acid biosynthetic process
HVY73_RS14740	COG3713	MltA-interacting MipA family protein
HVY73_RS14745	COG2766	serine protein kinase
HVY73_RS14760	COG0386	Belongs to the glutathione peroxidase family
HVY73_RS14785	COG1028	Short-chain dehydrogenase reductase Sdr
HVY73_RS14790	COG0583	DNA-binding transcription factor activity
HVY73_RS14795	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HVY73_RS14800	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HVY73_RS14810	COG0859	PFAM glycosyl transferase family 9
HVY73_RS14815	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HVY73_RS14825	COG2207	Transcriptional regulator
HVY73_RS14830	COG2807	transmembrane transport
HVY73_RS14835	COG0504	CTP synthase activity
HVY73_RS14840	COG1683	Conserved Protein
HVY73_RS14845	COG3189	MarR family transcriptional regulator
HVY73_RS14850	COG3042	response to heat
HVY73_RS14855	COG2203	Gaf domain
HVY73_RS14855	COG2199	diguanylate cyclase activity
HVY73_RS14875	COG3182	Iron-regulated membrane protein
HVY73_RS14885	COG1560	Kdo2-lipid A biosynthetic process
HVY73_RS14895	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HVY73_RS14900	COG3706	GGDEF domain
HVY73_RS14905	COG0583	DNA-binding transcription factor activity
HVY73_RS14910	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HVY73_RS14940	COG1294	oxidase, subunit
HVY73_RS14945	COG1271	oxidase subunit
HVY73_RS14950	COG3546	catalase activity
HVY73_RS14955	COG3685	Protein conserved in bacteria
HVY73_RS14960	COG3685	Protein conserved in bacteria
HVY73_RS14965	COG3729	General stress protein
HVY73_RS14970	COG1063	alcohol dehydrogenase
HVY73_RS14975	COG3813	Protein conserved in bacteria
HVY73_RS15000	COG0640	Transcriptional regulator
HVY73_RS15005	COG0538	isocitrate dehydrogenase activity
HVY73_RS15015	COG5001	Diguanylate cyclase
HVY73_RS15015	COG3300	MHYT domain
HVY73_RS15020	COG3706	GGDEF domain
HVY73_RS15105	COG0616	signal peptide processing
HVY73_RS15120	COG1802	Transcriptional regulator
HVY73_RS15120	COG4626	Terminase
HVY73_RS15160	COG3772	lysozyme
HVY73_RS15180	COG1403	HNH endonuclease
HVY73_RS15195	COG2378	regulation of single-species biofilm formation
HVY73_RS15200	COG1028	Short-chain dehydrogenase reductase Sdr
HVY73_RS15255	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVY73_RS15265	COG0582	viral genome integration into host DNA
HVY73_RS15270	COG0538	isocitrate dehydrogenase activity
HVY73_RS15275	COG1187	pseudouridine synthase activity
HVY73_RS15295	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HVY73_RS15315	COG2205	protein histidine kinase activity
HVY73_RS15320	COG2850	peptidyl-arginine hydroxylation
HVY73_RS15340	COG1177	transmembrane transport
HVY73_RS15355	COG0318	PFAM AMP-dependent synthetase and ligase
HVY73_RS15360	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HVY73_RS15365	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVY73_RS15370	COG0698	ribose 5-phosphate isomerase
HVY73_RS15385	COG3395	kinase activity
HVY73_RS15400	COG2390	Transcriptional regulator
HVY73_RS15410	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HVY73_RS15420	COG4591	ABC-type transport system involved in lipoprotein release permease component
HVY73_RS15430	COG4591	ABC-type transport system involved in lipoprotein release permease component
HVY73_RS15440	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HVY73_RS15445	COG1376	ErfK ybiS ycfS ynhG family protein
HVY73_RS15445	COG1388	LysM domain
HVY73_RS15460	COG1309	transcriptional regulator
HVY73_RS15475	COG3134	Outer membrane lipoprotein
HVY73_RS15480	COG1252	NADH dehydrogenase
HVY73_RS15505	COG5633	Lipoprotein
HVY73_RS15510	COG0537	adenosine 5'-monophosphoramidase activity
HVY73_RS15520	COG0084	hydrolase, TatD family'
HVY73_RS15525	COG0470	DNA polymerase III
HVY73_RS15535	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HVY73_RS15540	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HVY73_RS15545	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVY73_RS15580	COG1399	metal-binding, possibly nucleic acid-binding protein
HVY73_RS15600	COG1530	ribonuclease E activity
HVY73_RS15605	COG0583	DNA-binding transcription factor activity
HVY73_RS15610	COG2814	Major facilitator Superfamily
HVY73_RS15630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVY73_RS15675	COG1560	Kdo2-lipid A biosynthetic process
HVY73_RS15690	COG5645	(Lipo)protein
HVY73_RS15725	COG3381	protein complex oligomerization
HVY73_RS15750	COG0583	DNA-binding transcription factor activity
HVY73_RS15760	COG1335	isochorismatase
HVY73_RS15770	COG1702	phosphate starvation-inducible protein PhoH
HVY73_RS15790	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HVY73_RS15800	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HVY73_RS15815	COG1309	transcriptional regulator
HVY73_RS15850	COG2233	PERMEase
HVY73_RS15860	COG3729	General stress protein
HVY73_RS15890	COG1028	Short-chain dehydrogenase reductase Sdr
HVY73_RS15905	COG0531	amino acid
HVY73_RS15910	COG0174	glutamine synthetase
HVY73_RS15915	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HVY73_RS15920	COG1396	sequence-specific DNA binding
HVY73_RS15920	COG1917	Cupin 2, conserved barrel domain protein
HVY73_RS15925	COG1012	belongs to the aldehyde dehydrogenase family
HVY73_RS15930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HVY73_RS15935	COG0583	DNA-binding transcription factor activity
HVY73_RS15940	COG0473	3-isopropylmalate dehydrogenase activity
HVY73_RS15945	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HVY73_RS15950	COG4638	Rieske (2fe-2S)
HVY73_RS15955	COG1012	belongs to the aldehyde dehydrogenase family
HVY73_RS15960	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVY73_RS15985	COG0670	Belongs to the BI1 family
HVY73_RS16000	COG2207	Transcriptional regulator
HVY73_RS16005	COG1881	PFAM PEBP family protein
HVY73_RS16020	COG1832	CoA-binding protein
HVY73_RS16030	COG0210	DNA helicase
HVY73_RS16035	COG3304	Inner membrane component domain
HVY73_RS16040	COG1289	transmembrane transporter activity
HVY73_RS16045	COG3070	regulator of competence-specific genes
HVY73_RS16065	COG1067	ATP-dependent peptidase activity
HVY73_RS16075	COG3130	regulation of translation
HVY73_RS16080	COG3009	Protein conserved in bacteria
HVY73_RS16085	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HVY73_RS16085	COG3008	intermembrane lipid transfer
HVY73_RS16090	COG2995	paraquat-inducible protein a
HVY73_RS16095	COG0488	(ABC) transporter
HVY73_RS16105	COG0633	Ferredoxin
HVY73_RS16105	COG3217	Mosc domain protein beta barrel domain protein
HVY73_RS16120	COG0431	NADPH-dependent FMN reductase
HVY73_RS16125	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HVY73_RS16130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HVY73_RS16135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HVY73_RS16145	COG0308	aminopeptidase N
HVY73_RS16155	COG1473	amidohydrolase
HVY73_RS16165	COG0814	amino acid
HVY73_RS16185	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVY73_RS16190	COG1448	Aminotransferase
HVY73_RS16195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HVY73_RS16200	COG3108	Peptidase M15
HVY73_RS16205	COG2989	Protein conserved in bacteria
HVY73_RS16215	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HVY73_RS16225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HVY73_RS16230	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HVY73_RS16235	COG3173	Aminoglycoside phosphotransferase
HVY73_RS16250	COG3214	Protein conserved in bacteria
HVY73_RS16265	COG0658	competence protein
HVY73_RS16265	COG2333	competence protein COMEC
HVY73_RS16275	COG0539	negative regulation of cytoplasmic translation
HVY73_RS16295	COG2323	membrane
HVY73_RS16300	COG1944	ATP diphosphatase activity
HVY73_RS16305	COG2116	formate transmembrane transporter activity
HVY73_RS16310	COG1882	Formate acetyltransferase
HVY73_RS16315	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVY73_RS16320	COG0477	Major facilitator Superfamily
HVY73_RS16325	COG3302	dmso reductase anchor subunit
HVY73_RS16330	COG0437	4 iron, 4 sulfur cluster binding
HVY73_RS16335	COG0243	molybdopterin cofactor binding
HVY73_RS16345	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HVY73_RS16355	COG1674	ftsk spoiiie
HVY73_RS16355	COG1178	ABC-type Fe3 transport system permease component
HVY73_RS16365	COG0492	ferredoxin-NADP+ reductase activity
HVY73_RS16370	COG4988	ABC transporter
HVY73_RS16375	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HVY73_RS16390	COG0542	response to heat
HVY73_RS16400	COG1278	Cold shock
HVY73_RS16410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY73_RS16415	COG3593	DNA synthesis involved in DNA repair
HVY73_RS16425	COG2431	L-lysine efflux transmembrane transporter activity
HVY73_RS16435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVY73_RS16445	COG0028	Belongs to the TPP enzyme family
HVY73_RS16450	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HVY73_RS16455	COG0702	epimerase
HVY73_RS16460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVY73_RS16465	COG3023	N-Acetylmuramoyl-L-alanine amidase
HVY73_RS16470	COG3706	GGDEF domain
HVY73_RS16470	COG4251	negative regulation of phosphorylation
HVY73_RS16470	COG2203	Gaf domain
HVY73_RS16470	COG5001	Diguanylate cyclase
HVY73_RS16480	COG1126	abc transporter atp-binding protein
HVY73_RS16485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY73_RS16490	COG4215	(ABC) transporter
HVY73_RS16495	COG4160	amino acid transport
HVY73_RS16500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY73_RS16505	COG5002	protein histidine kinase activity
HVY73_RS16510	COG0745	RESPONSE REGULATOR receiver
HVY73_RS16525	COG1177	transmembrane transport
HVY73_RS16530	COG1176	ABC-type spermidine putrescine transport system, permease component I
HVY73_RS16535	COG3842	ATPase activity
HVY73_RS16540	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HVY73_RS16555	COG0778	Nitroreductase
HVY73_RS16580	COG3226	Transcriptional regulator
HVY73_RS16585	COG0738	Major facilitator superfamily
HVY73_RS16590	COG0561	phosphatase activity
HVY73_RS16595	COG2814	Major facilitator Superfamily
HVY73_RS16600	COG0671	phosphoesterase, PA-phosphatase related
HVY73_RS16605	COG1349	DNA-binding transcription factor activity
HVY73_RS16610	COG1686	Belongs to the peptidase S11 family
HVY73_RS16620	COG0625	glutathione transferase activity
HVY73_RS16625	COG2133	pyrroloquinoline quinone binding
HVY73_RS16635	COG2223	nitrite transmembrane transporter activity
HVY73_RS16655	COG0747	negative chemotaxis
HVY73_RS16670	COG0303	'Molybdopterin
HVY73_RS16675	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HVY73_RS16680	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVY73_RS16685	COG1882	Formate acetyltransferase
HVY73_RS16690	COG0561	phosphatase activity
HVY73_RS16700	COG1609	Transcriptional regulator
HVY73_RS16705	COG2271	Major facilitator Superfamily
HVY73_RS16715	COG0488	(ABC) transporter
HVY73_RS16720	COG2365	Tyrosine phosphatase family
HVY73_RS16725	COG1376	ErfK ybiS ycfS ynhG family protein
HVY73_RS16730	COG2188	Transcriptional regulator
HVY73_RS16735	COG2723	6-phospho-beta-galactosidase activity
HVY73_RS16740	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HVY73_RS16755	COG2194	sulfuric ester hydrolase activity
HVY73_RS16760	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HVY73_RS16775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY73_RS16780	COG0765	amino acid transport
HVY73_RS16785	COG1126	abc transporter atp-binding protein
HVY73_RS16790	COG0668	transmembrane transport
HVY73_RS16810	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HVY73_RS16820	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HVY73_RS16825	COG1199	ATP-dependent helicase activity
HVY73_RS16830	COG0513	Belongs to the DEAD box helicase family
HVY73_RS16835	COG3958	Transketolase
HVY73_RS16840	COG3959	Transketolase, thiamine diphosphate binding domain
HVY73_RS16845	COG1028	Short-chain dehydrogenase reductase Sdr
HVY73_RS16850	COG2271	Major facilitator Superfamily
HVY73_RS16860	COG0583	DNA-binding transcription factor activity
HVY73_RS16865	COG1309	transcriptional regulator
HVY73_RS16870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY73_RS16875	COG1131	(ABC) transporter
HVY73_RS16880	COG0842	Transport permease protein
HVY73_RS16885	COG0842	Transport permease protein
HVY73_RS16895	COG3568	Endonuclease Exonuclease Phosphatase
HVY73_RS16900	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVY73_RS16905	COG0392	lysyltransferase activity
HVY73_RS16910	COG0670	Belongs to the BI1 family
HVY73_RS16915	COG0314	molybdopterin synthase activity
HVY73_RS16920	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HVY73_RS16930	COG0521	Mo-molybdopterin cofactor biosynthetic process
HVY73_RS16950	COG0745	RESPONSE REGULATOR receiver
HVY73_RS16955	COG0642	Histidine kinase
HVY73_RS16980	COG2226	methyltransferase
HVY73_RS16995	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HVY73_RS17000	COG1881	PFAM PEBP family protein
HVY73_RS17040	COG4677	pectinesterase activity
HVY73_RS17050	COG0589	response to stress
HVY73_RS17090	COG0789	Transcriptional regulator
HVY73_RS17095	COG2200	EAL domain
HVY73_RS17120	COG0561	phosphatase activity
HVY73_RS17130	COG4149	molybdate abc transporter
HVY73_RS17135	COG0725	ABC transporter, periplasmic molybdate-binding protein
HVY73_RS17145	COG2005	Transcriptional regulator
HVY73_RS17145	COG3585	molybdate ion transport
HVY73_RS17150	COG1119	ATPase activity
HVY73_RS17160	COG1085	galactose-1-phosphate uridylyltransferase
HVY73_RS17170	COG2017	converts alpha-aldose to the beta-anomer
HVY73_RS17180	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HVY73_RS17195	COG3201	nicotinamide mononucleotide transporter
HVY73_RS17200	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HVY73_RS17250	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HVY73_RS17255	COG2885	chlorophyll binding
HVY73_RS17265	COG3064	Membrane
HVY73_RS17270	COG0848	biopolymer transport protein
HVY73_RS17275	COG0811	peptide transport
HVY73_RS17280	COG0824	Thioesterase
HVY73_RS17285	COG3790	cyd operon protein YbgE
HVY73_RS17290	COG4890	Cyd operon protein YbgT
HVY73_RS17295	COG1294	oxidase, subunit
HVY73_RS17300	COG1271	oxidase subunit
HVY73_RS17305	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVY73_RS17315	COG0508	dehydrogenase complex catalyzes the overall conversion of
HVY73_RS17320	COG0567	Dehydrogenase, E1 component
HVY73_RS17325	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HVY73_RS17330	COG1053	succinate dehydrogenase
HVY73_RS17335	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HVY73_RS17340	COG2009	succinate dehydrogenase
HVY73_RS17375	COG1984	allophanate hydrolase subunit 2
HVY73_RS17380	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HVY73_RS17395	COG0415	Belongs to the DNA photolyase family
HVY73_RS17425	COG2205	protein histidine kinase activity
HVY73_RS17430	COG0745	RESPONSE REGULATOR receiver
HVY73_RS17440	COG0033	Phosphoglucomutase
HVY73_RS17450	COG0596	Alpha beta hydrolase
HVY73_RS17465	COG0735	belongs to the Fur family
HVY73_RS17505	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HVY73_RS17510	COG1940	carbohydrate kinase activity
HVY73_RS17510	COG1846	Transcriptional regulator
HVY73_RS17515	COG0647	UMP catabolic process
HVY73_RS17520	COG0367	asparagine synthase
HVY73_RS17560	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVY73_RS17570	COG1702	phosphate starvation-inducible protein PhoH
HVY73_RS17595	COG0765	amino acid transport
HVY73_RS17600	COG0765	amino acid transport
HVY73_RS17605	COG1126	abc transporter atp-binding protein
HVY73_RS17620	COG2888	peptidyl-tyrosine sulfation
HVY73_RS17635	COG1466	dna polymerase III delta subunit
HVY73_RS17650	COG0799	negative regulation of ribosome biogenesis
HVY73_RS17660	COG0768	penicillin binding
HVY73_RS17665	COG0772	Belongs to the SEDS family
HVY73_RS17670	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HVY73_RS17675	COG1686	Belongs to the peptidase S11 family
HVY73_RS17690	COG0583	DNA-binding transcription factor activity
HVY73_RS17705	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVY73_RS17725	COG3069	C4-dicarboxylate transmembrane transporter activity
HVY73_RS17730	COG3719	Belongs to the RNase T2 family
HVY73_RS17735	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HVY73_RS17755	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVY73_RS17760	COG0583	DNA-binding transcription factor activity
HVY73_RS17765	COG3969	phosphoadenosine phosphosulfate
HVY73_RS17770	COG1475	DNA binding
HVY73_RS17775	COG0436	Aminotransferase
HVY73_RS17800	COG1129	ABC transporter
HVY73_RS17805	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY73_RS17810	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY73_RS17820	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HVY73_RS17835	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HVY73_RS17845	COG0402	S-adenosylhomocysteine deaminase activity
HVY73_RS17855	COG0483	inositol monophosphate 1-phosphatase activity
HVY73_RS17860	COG2271	Major facilitator Superfamily
HVY73_RS17890	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY73_RS17895	COG1129	ABC transporter
HVY73_RS17900	COG0371	Dehydrogenase
HVY73_RS17905	COG1028	Short-chain dehydrogenase reductase Sdr
HVY73_RS17920	COG2879	small protein
HVY73_RS17925	COG1966	Carbon starvation protein
HVY73_RS17935	COG1028	Short-chain dehydrogenase reductase Sdr
HVY73_RS17940	COG3433	isochorismatase activity
HVY73_RS17940	COG1535	isochorismatase
HVY73_RS17945	COG1021	2,3-dihydroxybenzoate-AMP ligase
HVY73_RS17950	COG1169	isochorismate synthase
HVY73_RS17955	COG4592	Periplasmic binding protein
HVY73_RS17965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY73_RS17970	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY73_RS17975	COG1120	ATPase activity
HVY73_RS17980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HVY73_RS17980	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HVY73_RS17985	COG3251	PFAM MbtH domain protein
HVY73_RS17990	COG2382	esterase
HVY73_RS17995	COG4771	TonB-dependent receptor
HVY73_RS18005	COG1879	ABC-type sugar transport system periplasmic component
HVY73_RS18015	COG1129	ABC transporter
HVY73_RS18020	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY73_RS18025	COG5464	transposase or invertase
HVY73_RS18030	COG2390	Transcriptional regulator
HVY73_RS18035	COG3959	Transketolase, thiamine diphosphate binding domain
HVY73_RS18040	COG3958	Transketolase
HVY73_RS18050	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HVY73_RS18060	COG0583	DNA-binding transcription factor activity
HVY73_RS18065	COG0668	transmembrane transport
HVY73_RS18075	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HVY73_RS18100	COG0747	negative chemotaxis
HVY73_RS18105	COG0601	transmembrane transport
HVY73_RS18110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVY73_RS18115	COG0444	Belongs to the ABC transporter superfamily
HVY73_RS18120	COG4608	Belongs to the ABC transporter superfamily
HVY73_RS18130	COG4221	oxidoreductase activity
HVY73_RS18140	COG4215	(ABC) transporter
HVY73_RS18145	COG0765	amino acid transport
HVY73_RS18150	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HVY73_RS18165	COG0697	spore germination
HVY73_RS18180	COG4608	Belongs to the ABC transporter superfamily
HVY73_RS18185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVY73_RS18195	COG4166	transmembrane transport
HVY73_RS18205	COG3698	Phosphodiester glycosidase
HVY73_RS18245	COG2315	Protein conserved in bacteria
HVY73_RS18250	COG0778	Nitroreductase
HVY73_RS18260	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY73_RS18270	COG3716	PTS system mannose fructose sorbose family IID component
HVY73_RS18275	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HVY73_RS18280	COG2222	sugar isomerase
HVY73_RS18285	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HVY73_RS18285	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HVY73_RS18300	COG0477	Major facilitator Superfamily
HVY73_RS18305	COG0668	transmembrane transport
HVY73_RS18320	COG0673	inositol 2-dehydrogenase activity
HVY73_RS18330	COG2211	Major facilitator Superfamily
HVY73_RS18335	COG1113	amino acid transport
HVY73_RS18350	COG1012	belongs to the aldehyde dehydrogenase family
HVY73_RS18355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HVY73_RS18365	COG0531	amino acid
HVY73_RS18410	COG0667	Aldo Keto reductase
HVY73_RS18415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY73_RS18420	COG1473	amidohydrolase
HVY73_RS18450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY73_RS18455	COG1120	ATPase activity
HVY73_RS18460	COG1566	PFAM secretion protein HlyD family protein
HVY73_RS18505	COG4211	Belongs to the binding-protein-dependent transport system permease family
HVY73_RS18510	COG1129	ABC transporter
HVY73_RS18525	COG0673	inositol 2-dehydrogenase activity
HVY73_RS18555	COG3104	oligopeptide transport
HVY73_RS18560	COG1982	Orn Lys Arg decarboxylase major
HVY73_RS18565	COG0531	amino acid
HVY73_RS18570	COG3710	Transcriptional regulator
HVY73_RS18580	COG1560	Kdo2-lipid A biosynthetic process
HVY73_RS18595	COG3188	usher protein
HVY73_RS18600	COG3121	Chaperone
HVY73_RS18605	COG3539	Fimbrial protein
HVY73_RS18655	COG2501	S4 domain
HVY73_RS18665	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HVY73_RS18680	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HVY73_RS18685	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HVY73_RS18705	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HVY73_RS18710	COG4181	ATPase activity
HVY73_RS18715	COG2755	lipolytic protein G-D-S-L family
HVY73_RS18720	COG0300	oxidoreductase activity
HVY73_RS18725	COG3118	belongs to the thioredoxin family
HVY73_RS18730	COG0390	transport system, permease component
HVY73_RS18735	COG4619	ABC transporter
HVY73_RS18740	COG0330	HflC and HflK could
HVY73_RS18745	COG1585	Membrane protein implicated in regulation of membrane protease activity
HVY73_RS18760	COG3735	TraB family
HVY73_RS18765	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HVY73_RS18775	COG2223	nitrite transmembrane transporter activity
HVY73_RS18780	COG4651	solute:proton antiporter activity
HVY73_RS18780	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HVY73_RS18785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY73_RS18825	COG2832	Protein of unknown function (DUF454)
HVY73_RS18830	COG3923	Primosomal replication protein n
HVY73_RS18845	COG3264	Mechanosensitive ion channel
HVY73_RS18845	COG1196	nuclear chromosome segregation
HVY73_RS18850	COG1309	transcriptional regulator
HVY73_RS18855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY73_RS18860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVY73_RS18875	COG0110	maltose O-acetyltransferase activity
HVY73_RS18925	COG1874	Beta-galactosidase
HVY73_RS18930	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HVY73_RS18935	COG3833	ABC-type maltose transport systems, permease component
HVY73_RS18940	COG1175	transmembrane transport
HVY73_RS18945	COG2182	Extracellular solute-binding protein
HVY73_RS18955	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HVY73_RS18970	COG2364	Membrane
HVY73_RS19000	COG3695	enzyme binding
HVY73_RS19005	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HVY73_RS19010	COG1946	Acyl-CoA thioesterase
HVY73_RS19015	COG0004	ammonium transporteR
HVY73_RS19020	COG0347	Belongs to the P(II) protein family
HVY73_RS19025	COG1132	(ABC) transporter
HVY73_RS19030	COG1132	(ABC) transporter
HVY73_RS19035	COG1522	sequence-specific DNA binding
HVY73_RS19050	COG4533	DNA binding
HVY73_RS19060	COG0824	Thioesterase
HVY73_RS19065	COG1555	photosystem II stabilization
HVY73_RS19070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVY73_RS19075	COG0776	regulation of translation
HVY73_RS19080	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HVY73_RS19100	COG0271	Belongs to the BolA IbaG family
HVY73_RS19105	COG3056	Lipoprotein
HVY73_RS19110	COG2223	nitrite transmembrane transporter activity
HVY73_RS19115	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HVY73_RS19120	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HVY73_RS19125	COG1845	cytochrome c oxidase, subunit III
HVY73_RS19130	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HVY73_RS19145	COG1414	Transcriptional regulator
HVY73_RS19150	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HVY73_RS19155	COG1053	succinate dehydrogenase
HVY73_RS19165	COG1053	succinate dehydrogenase
HVY73_RS19180	COG0673	inositol 2-dehydrogenase activity
HVY73_RS19185	COG2814	Major facilitator Superfamily
HVY73_RS19195	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HVY73_RS19200	COG0693	protein deglycase activity
HVY73_RS19220	COG0142	geranyltranstransferase activity
HVY73_RS19230	COG0667	Aldo Keto reductase
HVY73_RS19235	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HVY73_RS19255	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HVY73_RS19255	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HVY73_RS19265	COG4238	major outer membrane lipoprotein
HVY73_RS19285	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HVY73_RS19290	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HVY73_RS19295	COG1862	Preprotein translocase
HVY73_RS19320	COG0450	alkyl hydroperoxide reductase
HVY73_RS19340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY73_RS19350	COG1228	amidohydrolase
HVY73_RS19360	COG1335	isochorismatase
HVY73_RS19365	COG0583	DNA-binding transcription factor activity
HVY73_RS19370	COG0366	Alpha amylase catalytic
HVY73_RS19395	COG0420	3'-5' exonuclease activity
HVY73_RS19400	COG0419	ATPase involved in DNA repair
HVY73_RS19405	COG1940	carbohydrate kinase activity
HVY73_RS19420	COG4126	flavin adenine dinucleotide binding
HVY73_RS19430	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HVY73_RS19435	COG3416	Protein conserved in bacteria
HVY73_RS19445	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HVY73_RS19455	COG1785	Belongs to the alkaline phosphatase family
HVY73_RS19495	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HVY73_RS19500	COG1335	isochorismatase
HVY73_RS19505	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HVY73_RS19510	COG0113	porphobilinogen synthase activity
HVY73_RS19520	COG2175	clavaminate synthase activity
HVY73_RS19525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HVY73_RS19530	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HVY73_RS19535	COG4521	taurine ABC transporter
HVY73_RS19540	COG2040	homocysteine
HVY73_RS19545	COG0833	amino acid
HVY73_RS19560	COG4303	Ethanolamine ammonia lyase large subunit
HVY73_RS19565	COG4302	ethanolamine ammonia-lyase activity
HVY73_RS19605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY73_RS19610	COG1126	abc transporter atp-binding protein
HVY73_RS19615	COG4597	amino acid ABC transporter
HVY73_RS19620	COG0765	amino acid transport
HVY73_RS19635	COG3188	usher protein
HVY73_RS19660	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HVY73_RS19670	COG3639	organic phosphonate transmembrane transporter activity
HVY73_RS19690	COG0791	NLP P60 protein
HVY73_RS19715	COG0582	viral genome integration into host DNA
HVY73_RS19750	COG3121	Chaperone
HVY73_RS19755	COG3188	usher protein
HVY73_RS19790	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HVY73_RS19795	COG0022	dehydrogenase e1 component
HVY73_RS19800	COG0508	dehydrogenase complex catalyzes the overall conversion of
HVY73_RS19805	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVY73_RS19815	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HVY73_RS19830	COG0579	oxidoreductase
HVY73_RS19835	COG1012	belongs to the aldehyde dehydrogenase family
HVY73_RS19840	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HVY73_RS19845	COG1113	amino acid transport
HVY73_RS19850	COG1802	Transcriptional regulator
HVY73_RS19870	COG2195	Cleaves the N-terminal amino acid of tripeptides
HVY73_RS19875	COG0454	-acetyltransferase
HVY73_RS19890	COG2991	Protein conserved in bacteria
HVY73_RS19905	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HVY73_RS19910	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HVY73_RS19925	COG3034	peptidoglycan biosynthetic process
HVY73_RS19930	COG0121	glutamine amidotransferase
HVY73_RS19940	COG1960	acyl-CoA dehydrogenase activity
HVY73_RS19945	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVY73_RS19955	COG0583	DNA-binding transcription factor activity
HVY73_RS19965	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVY73_RS19975	COG2226	methyltransferase
HVY73_RS19985	COG1388	LysM domain
HVY73_RS19985	COG0741	lytic transglycosylase activity
HVY73_RS19990	COG2226	methyltransferase
HVY73_RS20000	COG2814	Major facilitator Superfamily
HVY73_RS20005	COG0583	DNA-binding transcription factor activity
HVY73_RS20010	COG0656	L-ascorbic acid biosynthetic process
HVY73_RS20045	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HVY73_RS20055	COG2011	ABC-type metal ion transport system permease component
HVY73_RS20060	COG1464	Belongs to the NlpA lipoprotein family
HVY73_RS20070	COG1720	tRNA m6t6A37 methyltransferase activity
HVY73_RS20080	COG0791	NLP P60 protein
HVY73_RS20085	COG3015	lipoprotein NlpE involved in copper resistance
HVY73_RS20090	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HVY73_RS20105	COG4568	rho-dependent transcription termination
HVY73_RS20115	COG0346	lactoylglutathione lyase activity
HVY73_RS20130	COG0587	DNA-directed DNA polymerase activity
HVY73_RS20160	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HVY73_RS20170	COG0750	zinc metalloprotease
HVY73_RS20175	COG0575	Belongs to the CDS family
HVY73_RS20185	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HVY73_RS20210	COG0024	Methionine aminopeptidase
HVY73_RS20215	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HVY73_RS20230	COG3835	regulator
HVY73_RS20235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVY73_RS20255	COG2860	membrane
HVY73_RS20275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY73_RS20280	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HVY73_RS20285	COG1120	ATPase activity
HVY73_RS20290	COG4774	siderophore transport
HVY73_RS20295	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HVY73_RS20390	COG1643	Atp-dependent helicase
HVY73_RS20395	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HVY73_RS20415	COG0617	tRNA 3'-terminal CCA addition
HVY73_RS20420	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HVY73_RS20440	COG0726	polysaccharide deacetylase
HVY73_RS20445	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY73_RS20450	COG0842	Transport permease protein
HVY73_RS20455	COG1131	(ABC) transporter
HVY73_RS20460	COG0288	reversible hydration of carbon dioxide
HVY73_RS20475	COG4993	Dehydrogenase
HVY73_RS20480	COG2132	Multicopper oxidase
HVY73_RS20525	COG3064	Membrane
HVY73_RS20540	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVY73_RS20545	COG0508	dehydrogenase complex catalyzes the overall conversion of
HVY73_RS20550	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HVY73_RS20555	COG2186	Transcriptional regulator
HVY73_RS20560	COG1113	amino acid transport
HVY73_RS20565	COG2211	Major facilitator Superfamily
HVY73_RS20570	COG3940	Belongs to the glycosyl hydrolase 43 family
HVY73_RS20575	COG3725	Membrane protein required for beta-lactamase induction
HVY73_RS20580	COG3023	N-Acetylmuramoyl-L-alanine amidase
HVY73_RS20590	COG4969	Belongs to the N-Me-Phe pilin family
HVY73_RS20595	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HVY73_RS20600	COG1459	type II secretion system
HVY73_RS20625	COG0494	nUDIX hydrolase
HVY73_RS20645	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HVY73_RS20650	COG0849	cell division
HVY73_RS20675	COG0772	Belongs to the SEDS family
HVY73_RS20690	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HVY73_RS20695	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HVY73_RS20700	COG0768	penicillin binding
HVY73_RS20720	COG1609	Transcriptional regulator
HVY73_RS20730	COG0028	Belongs to the TPP enzyme family
HVY73_RS20775	COG0738	Major facilitator superfamily
HVY73_RS20785	COG0583	DNA-binding transcription factor activity
HVY73_RS20790	COG2271	Major facilitator Superfamily
HVY73_RS20795	COG2814	Major facilitator Superfamily
HVY73_RS20815	COG1178	ABC-type Fe3 transport system permease component
HVY73_RS20825	COG0586	Pfam SNARE associated Golgi protein
HVY73_RS20845	COG0235	Class ii aldolase
HVY73_RS20850	COG0417	DNA replication proofreading
HVY73_RS20860	COG0564	pseudouridine synthase activity
HVY73_RS20870	COG3493	citrate carrier protein
HVY73_RS20885	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HVY73_RS20890	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HVY73_RS20900	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HVY73_RS20945	COG0505	Belongs to the CarA family
HVY73_RS21010	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HVY73_RS21020	COG3152	Membrane
HVY73_RS21035	COG1047	Peptidyl-prolyl cis-trans
HVY73_RS21050	COG0196	riboflavin kinase activity
HVY73_RS21060	COG0583	DNA-binding transcription factor activity
HVY73_RS21085	COG4735	regulation of single-species biofilm formation
HVY73_RS21090	COG1584	GPR1 FUN34 yaaH family protein
HVY73_RS21095	COG0477	Major facilitator Superfamily
HVY73_RS21100	COG0521	Mo-molybdopterin cofactor biosynthetic process
HVY73_RS21105	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVY73_RS21110	COG1115	amino acid carrier protein
HVY73_RS21125	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HVY73_RS21135	COG0527	aspartate kinase activity
HVY73_RS21135	COG0460	homoserine dehydrogenase
HVY73_RS21145	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HVY73_RS21155	COG0745	RESPONSE REGULATOR receiver
HVY73_RS21160	COG4452	Inner membrane protein CreD
HVY73_RS21165	COG2205	protein histidine kinase activity
HVY73_RS21170	COG0745	RESPONSE REGULATOR receiver
HVY73_RS21175	COG3045	CreA protein
HVY73_RS21180	COG3708	Transcriptional regulator
HVY73_RS21180	COG2207	Transcriptional regulator
HVY73_RS21200	COG0741	lytic transglycosylase activity
HVY73_RS21205	COG0488	(ABC) transporter
HVY73_RS21215	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HVY73_RS21220	COG0560	Phosphoserine phosphatase
HVY73_RS21225	COG3726	membrane protein affecting hemolysin expression
HVY73_RS21255	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HVY73_RS21260	COG0084	hydrolase, TatD family'
HVY73_RS21265	COG4667	esterase of the alpha-beta hydrolase superfamily
HVY73_RS21275	COG2823	Periplasmic or secreted lipoprotein
HVY73_RS21285	COG1011	Hydrolase
HVY73_RS21290	COG0456	acetyltransferase
HVY73_RS21295	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HVY73_RS21330	COG3706	GGDEF domain
HVY73_RS21335	COG4114	ferric iron reductase
HVY73_RS21340	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVY73_RS21340	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVY73_RS21345	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HVY73_RS21350	COG2197	response regulator
HVY73_RS21355	COG2197	response regulator
HVY73_RS21370	COG2966	Psort location CytoplasmicMembrane, score
HVY73_RS21385	COG1484	DNA-dependent DNA replication
HVY73_RS21400	COG5464	transposase or invertase
HVY73_RS21410	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HVY73_RS21415	COG3716	PTS system mannose fructose sorbose family IID component
HVY73_RS21420	COG3715	PTS system
HVY73_RS21435	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HVY73_RS21435	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HVY73_RS21440	COG1214	PFAM Peptidase M22, glycoprotease
HVY73_RS21440	COG0456	acetyltransferase
HVY73_RS21450	COG1737	Transcriptional regulator
HVY73_RS21455	COG0800	Aldolase
HVY73_RS21460	COG3734	2-keto-3-deoxy-galactonokinase
HVY73_RS21475	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HVY73_RS21500	COG1846	Transcriptional regulator
HVY73_RS21510	COG0179	Fumarylacetoacetate (FAA) hydrolase
HVY73_RS21520	COG1012	belongs to the aldehyde dehydrogenase family
HVY73_RS21525	COG3384	dioxygenase
HVY73_RS21535	COG3971	2-oxopent-4-enoate hydratase activity
HVY73_RS21555	COG2368	4-hydroxyphenylacetate
HVY73_RS21560	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HVY73_RS21565	COG1966	Carbon starvation protein
HVY73_RS21570	COG2879	small protein
HVY73_RS21575	COG0523	cobalamin synthesis protein
HVY73_RS21585	COG1012	belongs to the aldehyde dehydrogenase family
HVY73_RS21590	COG5464	transposase or invertase
HVY73_RS21595	COG1917	Cupin 2, conserved barrel domain protein
HVY73_RS21595	COG2207	Transcriptional regulator
HVY73_RS21605	COG2733	membrane
HVY73_RS21620	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HVY73_RS21625	COG1924	4 iron, 4 sulfur cluster binding
HVY73_RS21640	COG1566	PFAM secretion protein HlyD family protein
HVY73_RS21650	COG5457	Domain of unknown function (DUF1127)
HVY73_RS21655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HVY73_RS21665	COG0583	DNA-binding transcription factor activity
HVY73_RS21670	COG2249	NAD(P)H dehydrogenase (quinone) activity
HVY73_RS21680	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY73_RS21685	COG1129	ABC transporter
HVY73_RS21690	COG1879	ABC-type sugar transport system periplasmic component
HVY73_RS21700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY73_RS21705	COG0842	Transport permease protein
HVY73_RS21705	COG1129	ABC transporter
HVY73_RS21710	COG0842	Transport permease protein
HVY73_RS21740	COG2850	peptidyl-arginine hydroxylation
HVY73_RS21755	COG5002	protein histidine kinase activity
HVY73_RS21760	COG0745	RESPONSE REGULATOR receiver
HVY73_RS21765	COG1538	Outer membrane efflux protein
HVY73_RS21770	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY73_RS21775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY73_RS21780	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVY73_RS21790	COG3040	lipid binding
HVY73_RS21795	COG0789	Transcriptional regulator
HVY73_RS21800	COG3631	Ketosteroid isomerase-related protein
HVY73_RS21805	COG0300	oxidoreductase activity
HVY73_RS21820	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HVY73_RS21840	COG3272	Protein of unknown function (DUF1722)
HVY73_RS21845	COG4580	involved in the transport of maltose and maltodextrins
HVY73_RS21855	COG2211	Major facilitator Superfamily
HVY73_RS21860	COG3507	Belongs to the glycosyl hydrolase 43 family
HVY73_RS21925	COG0288	reversible hydration of carbon dioxide
HVY73_RS21930	COG0659	secondary active sulfate transmembrane transporter activity
HVY73_RS21935	COG1064	alcohol dehydrogenase
HVY73_RS21940	COG1175	transmembrane transport
HVY73_RS21945	COG0395	ABC-type sugar transport system, permease component
HVY73_RS21950	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HVY73_RS21955	COG3842	ATPase activity
HVY73_RS21970	COG1082	Xylose isomerase domain protein TIM barrel
HVY73_RS21980	COG3962	Belongs to the TPP enzyme family
HVY73_RS21985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY73_RS21990	COG1737	Transcriptional regulator
HVY73_RS21990	COG0837	glucose binding
HVY73_RS21995	COG3718	enzyme involved in inositol metabolism
HVY73_RS22010	COG0433	COG0433 Predicted ATPase
HVY73_RS22015	COG0795	lipopolysaccharide-transporting ATPase activity
HVY73_RS22020	COG0795	lipopolysaccharide-transporting ATPase activity
HVY73_RS22030	COG2927	DNA polymerase III (CHI subunit)
HVY73_RS22035	COG0525	valine-tRNA ligase activity
HVY73_RS22060	COG2188	Transcriptional regulator
HVY73_RS22065	COG1288	antiporter activity
HVY73_RS22070	COG1228	amidohydrolase
HVY73_RS22075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY73_RS22080	COG2222	sugar isomerase
HVY73_RS22085	COG2731	YhcH YjgK YiaL family protein
HVY73_RS22120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY73_RS22120	COG1263	PTS System
HVY73_RS22125	COG0366	Alpha amylase catalytic
HVY73_RS22130	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVY73_RS22135	COG1486	melibiose metabolic process
HVY73_RS22160	COG0602	queuosine metabolic process
HVY73_RS22165	COG2026	Addiction module toxin, RelE StbE family
HVY73_RS22170	COG3077	Addiction module antitoxin, RelB DinJ family
HVY73_RS22175	COG3711	transcriptional antiterminator
HVY73_RS22175	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY73_RS22180	COG2706	6-phosphogluconolactonase activity
HVY73_RS22195	COG3964	amidohydrolase
HVY73_RS22235	COG0312	modulator of DNA gyrase
HVY73_RS22260	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HVY73_RS22270	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY73_RS22275	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY73_RS22280	COG1129	ABC transporter
HVY73_RS22285	COG1879	ABC-type sugar transport system periplasmic component
HVY73_RS22300	COG2105	PFAM AIG2 family protein
HVY73_RS22305	COG2911	Protein conserved in bacteria
HVY73_RS22310	COG0729	surface antigen
HVY73_RS22320	COG1253	flavin adenine dinucleotide binding
HVY73_RS22335	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HVY73_RS22350	COG1733	regulation of RNA biosynthetic process
HVY73_RS22355	COG0702	epimerase
HVY73_RS22365	COG0697	spore germination
HVY73_RS22375	COG1113	amino acid transport
HVY73_RS22380	COG0545	Peptidyl-prolyl cis-trans isomerase
HVY73_RS22385	COG3061	Opacity-associated protein A
HVY73_RS22390	COG1309	transcriptional regulator
HVY73_RS22405	COG1024	Enoyl-CoA hydratase
HVY73_RS22410	COG4670	ketone body catabolic process
HVY73_RS22415	COG1053	succinate dehydrogenase
HVY73_RS22420	COG2271	Major facilitator Superfamily
HVY73_RS22430	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HVY73_RS22435	COG2965	DNA replication, synthesis of RNA primer
HVY73_RS22495	COG1073	alpha beta
HVY73_RS22500	COG3650	response to hydrogen peroxide
HVY73_RS22510	COG1960	acyl-CoA dehydrogenase activity
HVY73_RS22515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVY73_RS22520	COG0557	exoribonuclease II activity
HVY73_RS22535	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HVY73_RS22545	COG0330	HflC and HflK could
HVY73_RS22550	COG0330	HflC and HflK could
HVY73_RS22555	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HVY73_RS22575	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVY73_RS22580	COG0802	atpase or kinase
HVY73_RS22585	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HVY73_RS22585	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HVY73_RS22590	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HVY73_RS22610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY73_RS22630	COG3264	Mechanosensitive ion channel
HVY73_RS22630	COG1511	domain protein
HVY73_RS22645	COG1053	succinate dehydrogenase
HVY73_RS22650	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HVY73_RS22670	COG2076	Multidrug Resistance protein
HVY73_RS22675	COG5510	response to toxic substance
HVY73_RS22690	COG1509	lysine 2,3-aminomutase activity
HVY73_RS22695	COG0745	RESPONSE REGULATOR receiver
HVY73_RS22730	COG3188	usher protein
HVY73_RS22735	COG3539	Fimbrial protein
HVY73_RS22755	COG0531	amino acid
HVY73_RS22760	COG3030	protein affecting phage T7 exclusion by the F plasmid
HVY73_RS22765	COG1027	Aspartate ammonia-lyase
HVY73_RS22770	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HVY73_RS22785	COG1309	transcriptional regulator
HVY73_RS22830	COG0457	Tetratricopeptide repeat
HVY73_RS22835	COG0726	polysaccharide deacetylase
HVY73_RS22835	COG1649	PFAM Uncharacterised BCR, COG1649
HVY73_RS22840	COG1215	transferase activity, transferring glycosyl groups
HVY73_RS22855	COG0861	Integral membrane protein TerC family
HVY73_RS22895	COG1486	melibiose metabolic process
HVY73_RS22900	COG2169	Transcriptional regulator
HVY73_RS22910	COG2824	Alkylphosphonate utilization operon protein PhnA
HVY73_RS22915	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HVY73_RS22920	COG2188	Transcriptional regulator
HVY73_RS22925	COG3624	Phosphonate C-P lyase system protein PhnG
HVY73_RS22930	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HVY73_RS22935	COG3626	phosphonate metabolism
HVY73_RS22940	COG3627	carbon phosphorus lyase activity
HVY73_RS22945	COG4107	phosphonate C-P lyase system protein PhnK
HVY73_RS22950	COG4778	phosphonate C-P lyase system protein PhnL
HVY73_RS22955	COG3454	Phosphonate metabolism
HVY73_RS22965	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HVY73_RS22975	COG4191	Histidine kinase
HVY73_RS22975	COG0784	Response regulator, receiver
HVY73_RS22980	COG1129	ABC transporter
HVY73_RS22985	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY73_RS23020	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HVY73_RS23025	COG1301	dicarboxylic acid transport
HVY73_RS23035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HVY73_RS23040	COG3162	membrane
HVY73_RS23070	COG3539	Fimbrial protein
HVY73_RS23075	COG1346	cytolysis
HVY73_RS23080	COG1380	Effector of murein hydrolase LrgA
HVY73_RS23085	COG0583	DNA-binding transcription factor activity
HVY73_RS23090	COG0025	NhaP-type Na H and K H
HVY73_RS23095	COG2252	PERMEase
HVY73_RS23100	COG0625	glutathione transferase activity
HVY73_RS23105	COG0789	Transcriptional regulator
HVY73_RS23115	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HVY73_RS23145	COG1234	tRNA 3'-trailer cleavage
HVY73_RS23150	COG1609	Transcriptional regulator
HVY73_RS23155	COG0483	inositol monophosphate 1-phosphatase activity
HVY73_RS23165	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVY73_RS23185	COG4771	TonB-dependent receptor
HVY73_RS23190	COG0741	lytic transglycosylase activity
HVY73_RS23205	COG2315	Protein conserved in bacteria
HVY73_RS23210	COG0432	Pfam Uncharacterised protein family UPF0047
HVY73_RS23225	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HVY73_RS23230	COG0305	Participates in initiation and elongation during chromosome replication
HVY73_RS23245	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HVY73_RS23255	COG0735	belongs to the Fur family
HVY73_RS23260	COG3237	CsbD-like
HVY73_RS23270	COG0534	Mate efflux family protein
HVY73_RS23280	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HVY73_RS23350	COG0251	oxidation-reduction process
HVY73_RS23360	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HVY73_RS23370	COG0527	aspartate kinase activity
HVY73_RS23425	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HVY73_RS23455	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HVY73_RS23465	COG0456	acetyltransferase
HVY73_RS23495	COG0151	Belongs to the GarS family
HVY73_RS23505	COG4191	Histidine kinase
HVY73_RS23510	COG3678	ATP-independent chaperone mediated protein folding
HVY73_RS23545	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HVY73_RS23560	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HVY73_RS23565	COG2104	thiamine diphosphate biosynthetic process
HVY73_RS23580	COG3706	GGDEF domain
HVY73_RS23590	COG1447	Phosphotransferase system cellobiose-specific component IIA
HVY73_RS23595	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HVY73_RS23630	COG0250	Participates in transcription elongation, termination and antitermination
HVY73_RS23675	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HVY73_RS23705	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HVY73_RS23715	COG1739	Uncharacterized protein family UPF0029
HVY73_RS23755	COG0805	protein transport
HVY73_RS23775	COG3165	ubiquinone biosynthetic process from chorismate
HVY73_RS23805	COG0583	DNA-binding transcription factor activity
HVY73_RS23810	COG0697	spore germination
HVY73_RS23815	COG0561	phosphatase activity
HVY73_RS23820	COG2267	carboxylic ester hydrolase activity
HVY73_RS23825	COG1280	lysine exporter protein (LysE YggA)
HVY73_RS23835	COG1280	lysine exporter protein (LysE YggA)
HVY73_RS23865	COG0210	DNA helicase
HVY73_RS23870	COG1011	Hydrolase
HVY73_RS23900	COG3072	Adenylate cyclase
HVY73_RS23915	COG2959	enzyme of heme biosynthesis
HVY73_RS23920	COG3071	HemY protein
HVY73_RS23965	COG2244	polysaccharide biosynthetic process
HVY73_RS23970	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HVY73_RS23975	COG0456	acetyltransferase
HVY73_RS23980	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HVY73_RS23985	COG1088	dTDP-glucose 4,6-dehydratase activity
HVY73_RS23990	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HVY73_RS23995	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HVY73_RS24005	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HVY73_RS24010	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HVY73_RS24015	COG3118	belongs to the thioredoxin family
HVY73_RS24040	COG1811	Na channel or pump
HVY73_RS24050	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVY73_RS24055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVY73_RS24065	COG0583	DNA-binding transcription factor activity
HVY73_RS24070	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HVY73_RS24085	COG3978	acetolactate synthase activity
HVY73_RS24105	COG3085	chromosome segregation
HVY73_RS24180	COG0583	DNA-binding transcription factor activity
HVY73_RS24195	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HVY73_RS24210	COG3443	Belongs to the bacterial solute-binding protein 9 family
HVY73_RS24215	COG2207	Transcriptional regulator
HVY73_RS24225	COG0371	Dehydrogenase
HVY73_RS24230	COG0697	spore germination
HVY73_RS24240	COG0583	DNA-binding transcription factor activity
HVY73_RS24250	COG0737	Belongs to the 5'-nucleotidase family
HVY73_RS24260	COG0527	aspartate kinase activity
HVY73_RS24260	COG0460	homoserine dehydrogenase
HVY73_RS24265	COG0626	cystathionine gamma-synthase activity
HVY73_RS24280	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HVY73_RS24285	COG1609	Transcriptional regulator
HVY73_RS24290	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HVY73_RS24305	COG1575	Belongs to the MenA family. Type 1 subfamily
HVY73_RS24325	COG3678	ATP-independent chaperone mediated protein folding
HVY73_RS24330	COG0745	RESPONSE REGULATOR receiver
HVY73_RS24335	COG2205	protein histidine kinase activity
HVY73_RS24340	COG2258	MOSC domain
HVY73_RS24345	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HVY73_RS24385	COG1129	ABC transporter
HVY73_RS24390	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY73_RS24395	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY73_RS24400	COG1454	alcohol dehydrogenase
HVY73_RS24410	COG2211	Major facilitator Superfamily
HVY73_RS24470	COG0205	6-phosphofructokinase activity
HVY73_RS24490	COG0437	4 iron, 4 sulfur cluster binding
HVY73_RS24495	COG2864	formate dehydrogenase
HVY73_RS24510	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HVY73_RS24520	COG0456	acetyltransferase
HVY73_RS24535	COG1011	Hydrolase
HVY73_RS24550	COG3852	Histidine kinase
HVY73_RS24565	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HVY73_RS24585	COG0204	Acyl-transferase
HVY73_RS24595	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HVY73_RS24600	COG3084	Protein conserved in bacteria
HVY73_RS24610	COG1763	Mo-molybdopterin cofactor biosynthetic process
HVY73_RS24635	COG2186	Transcriptional regulator
HVY73_RS24640	COG0477	Major facilitator Superfamily
HVY73_RS24645	COG1609	Transcriptional regulator
HVY73_RS24650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY73_RS24660	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY73_RS24665	COG1129	ABC transporter
HVY73_RS24695	COG1522	sequence-specific DNA binding
HVY73_RS24700	COG0716	FMN binding
HVY73_RS24715	COG3312	ion transport
HVY73_RS24765	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HVY73_RS24770	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HVY73_RS24775	COG0573	inorganic phosphate transmembrane transporter activity
HVY73_RS24780	COG0581	inorganic phosphate transmembrane transporter activity
HVY73_RS24785	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HVY73_RS24790	COG0704	Plays a role in the regulation of phosphate uptake
HVY73_RS24800	COG2382	esterase
HVY73_RS24805	COG0363	glucosamine-6-phosphate deaminase activity
HVY73_RS24810	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVY73_RS24815	COG2252	PERMEase
HVY73_RS24820	COG0431	NADPH-dependent FMN reductase
HVY73_RS24825	COG2091	lysine biosynthetic process via aminoadipic acid
HVY73_RS24855	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HVY73_RS25095	COG5642	Protein of unknown function (DUF2384)
HVY73_RS25100	COG5654	RES domain protein
HVY73_RS25235	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVY73_RS25275	COG2916	Histone family protein nucleoid-structuring protein H-NS
HVY73_RS25370	COG1358	cellular component organization or biogenesis
HVY73_RS25535	COG0210	DNA helicase
HVY73_RS25820	COG0633	Ferredoxin
HVY73_RS25900	COG3969	phosphoadenosine phosphosulfate
HVY73_RS25905	COG1475	DNA binding
HVY73_RS26010	COG1376	ErfK ybiS ycfS ynhG family protein
HVY73_RS26025	COG1120	ATPase activity
HVY73_RS26035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY73_RS26045	COG0523	cobalamin synthesis protein
HVY73_RS26050	COG0500	methyltransferase
HVY73_RS26055	COG1304	FMN binding
HVY73_RS26060	COG2259	Doxx family
HVY73_RS26070	COG0523	cobalamin synthesis protein
HVY73_RS26200	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HVY73_RS26210	COG2337	Toxic component of a toxin-antitoxin (TA) module
HVY73_RS26250	COG2801	Transposase and inactivated derivatives
HVY73_RS26360	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HVY73_RS26565	COG5499	transcription regulator containing HTH domain
HVY73_RS26760	COG1475	DNA binding
HVY73_RS26765	COG1475	DNA binding
HVY73_RS26910	COG2176	DNA-directed DNA polymerase activity
HVY73_RS26935	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HVY73_RS26955	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVY73_RS26970	COG0419	ATPase involved in DNA repair
HVY73_RS27045	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HVY73_RS27125	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HVY73_RS27275	COG3941	tape measure
HVY73_RS27400	COG4626	Terminase
HVY73_RS27400	COG1802	Transcriptional regulator
HVY73_RS27410	COG0616	signal peptide processing
HVY73_RS27575	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVY73_RS27765	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol