locus-tag	class	description
HV197_RS00020	COG0187	DNA topoisomerase II activity
HV197_RS00025	COG0561	phosphatase activity
HV197_RS00040	COG2186	Transcriptional regulator
HV197_RS00045	COG3734	2-keto-3-deoxy-galactonokinase
HV197_RS00050	COG0800	Aldolase
HV197_RS00060	COG2271	Major facilitator Superfamily
HV197_RS00065	COG0823	Involved in the tonB-independent uptake of proteins
HV197_RS00070	COG5645	(Lipo)protein
HV197_RS00085	COG3645	SOS response
HV197_RS00095	COG2188	Transcriptional regulator
HV197_RS00110	COG2149	membrane
HV197_RS00130	COG2610	gluconate transmembrane transporter activity
HV197_RS00145	COG2814	Major facilitator Superfamily
HV197_RS00175	COG0028	Belongs to the TPP enzyme family
HV197_RS00180	COG0440	acetolactate synthase activity
HV197_RS00185	COG2197	response regulator
HV197_RS00195	COG2271	Major facilitator Superfamily
HV197_RS00235	COG2188	Transcriptional regulator
HV197_RS00260	COG4580	involved in the transport of maltose and maltodextrins
HV197_RS00265	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV197_RS00270	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV197_RS00270	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV197_RS00280	COG1609	Transcriptional regulator
HV197_RS00290	COG3384	dioxygenase
HV197_RS00295	COG0583	DNA-binding transcription factor activity
HV197_RS00300	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HV197_RS00305	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HV197_RS00310	COG2828	Protein conserved in bacteria
HV197_RS00325	COG0697	spore germination
HV197_RS00330	COG1263	PTS System
HV197_RS00330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV197_RS00340	COG2814	Major facilitator Superfamily
HV197_RS00350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV197_RS00385	COG0583	DNA-binding transcription factor activity
HV197_RS00410	COG1464	Belongs to the NlpA lipoprotein family
HV197_RS00425	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HV197_RS00435	COG1064	alcohol dehydrogenase
HV197_RS00490	COG2211	Major facilitator Superfamily
HV197_RS00495	COG1501	Belongs to the glycosyl hydrolase 31 family
HV197_RS00505	COG1486	melibiose metabolic process
HV197_RS00510	COG1263	PTS System
HV197_RS00510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV197_RS00515	COG2982	Protein involved in outer membrane biogenesis
HV197_RS00520	COG2233	PERMEase
HV197_RS00525	COG0786	glutamate:sodium symporter activity
HV197_RS00545	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HV197_RS00570	COG3152	Membrane
HV197_RS00580	COG1494	fructose-1,6-bisphosphatase
HV197_RS00585	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HV197_RS00590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV197_RS00595	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV197_RS00615	COG2860	membrane
HV197_RS00625	COG2169	Transcriptional regulator
HV197_RS00625	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HV197_RS00630	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HV197_RS00635	COG1561	YicC-like family, N-terminal region
HV197_RS00655	COG1131	(ABC) transporter
HV197_RS00660	COG0842	Transport permease protein
HV197_RS00690	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HV197_RS00725	COG1519	Transferase
HV197_RS00730	COG1216	Glycosyl transferase, family 2
HV197_RS00735	COG0438	transferase activity, transferring glycosyl groups
HV197_RS00745	COG0859	PFAM glycosyl transferase family 9
HV197_RS00770	COG0859	PFAM glycosyl transferase family 9
HV197_RS00785	COG0156	8-amino-7-oxononanoate synthase activity
HV197_RS00795	COG0463	Glycosyl transferase, family 2
HV197_RS00800	COG2861	carbohydrate metabolic process
HV197_RS00805	COG4942	peptidase
HV197_RS00815	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV197_RS00820	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HV197_RS00840	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HV197_RS00850	COG2186	Transcriptional regulator
HV197_RS00870	COG3722	fumarate hydratase activity
HV197_RS00885	COG0625	glutathione transferase activity
HV197_RS00895	COG3276	selenocysteine insertion sequence binding
HV197_RS00900	COG0235	Class ii aldolase
HV197_RS00905	COG3623	hexulose-6-phosphate isomerase
HV197_RS00910	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HV197_RS00915	COG1070	Carbohydrate kinase
HV197_RS00920	COG2271	Major facilitator Superfamily
HV197_RS00930	COG2731	YhcH YjgK YiaL family protein
HV197_RS00940	COG1414	Transcriptional regulator
HV197_RS00945	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV197_RS00950	COG3977	Valine--pyruvate aminotransferase
HV197_RS00955	COG0366	Alpha amylase catalytic
HV197_RS00960	COG2992	FlgJ-related protein
HV197_RS00965	COG2207	Transcriptional regulator
HV197_RS00965	COG1609	Transcriptional regulator
HV197_RS00970	COG4214	carbohydrate transport
HV197_RS00980	COG4213	ABC transporter substrate-binding protein
HV197_RS00995	COG4682	membrane
HV197_RS01000	COG4682	membrane
HV197_RS01005	COG3274	enterobacterial common antigen metabolic process
HV197_RS01035	COG1278	Cold shock
HV197_RS01040	COG2944	sequence-specific DNA binding
HV197_RS01045	COG2814	Major facilitator Superfamily
HV197_RS01065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV197_RS01075	COG1609	Transcriptional regulator
HV197_RS01080	COG2885	chlorophyll binding
HV197_RS01085	COG0243	molybdopterin cofactor binding
HV197_RS01090	COG0456	acetyltransferase
HV197_RS01095	COG2818	Glycosylase
HV197_RS01100	COG5571	outer membrane autotransporter
HV197_RS01105	COG2223	nitrite transmembrane transporter activity
HV197_RS01130	COG0747	negative chemotaxis
HV197_RS01135	COG0601	transmembrane transport
HV197_RS01140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV197_RS01145	COG0444	Belongs to the ABC transporter superfamily
HV197_RS01150	COG4608	Belongs to the ABC transporter superfamily
HV197_RS01165	COG2894	cell division
HV197_RS01175	COG1215	transferase activity, transferring glycosyl groups
HV197_RS01180	COG0457	Tetratricopeptide repeat
HV197_RS01195	COG2194	sulfuric ester hydrolase activity
HV197_RS01225	COG1215	transferase activity, transferring glycosyl groups
HV197_RS01230	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HV197_RS01235	COG3118	belongs to the thioredoxin family
HV197_RS01235	COG0457	Tetratricopeptide repeat
HV197_RS01240	COG2200	EAL domain
HV197_RS01240	COG2199	diguanylate cyclase activity
HV197_RS01250	COG0612	Peptidase, M16
HV197_RS01260	COG2982	Protein involved in outer membrane biogenesis
HV197_RS01265	COG0477	Major facilitator Superfamily
HV197_RS01270	COG1295	ribonuclease BN
HV197_RS01275	COG0583	DNA-binding transcription factor activity
HV197_RS01280	COG1028	Short-chain dehydrogenase reductase Sdr
HV197_RS01285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV197_RS01295	COG1454	alcohol dehydrogenase
HV197_RS01305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV197_RS01310	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HV197_RS01315	COG0671	phosphoesterase, PA-phosphatase related
HV197_RS01335	COG0589	response to stress
HV197_RS01345	COG0306	phosphate transporter
HV197_RS01350	COG2081	HI0933 family
HV197_RS01355	COG2239	Acts as a magnesium transporter
HV197_RS01365	COG1124	(ABC) transporter
HV197_RS01375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV197_RS01380	COG0601	transmembrane transport
HV197_RS01385	COG0747	negative chemotaxis
HV197_RS01395	COG3479	Phenolic acid decarboxylase
HV197_RS01435	COG0628	permease
HV197_RS01440	COG0477	Major facilitator Superfamily
HV197_RS01450	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HV197_RS01465	COG3714	YhhN family
HV197_RS01475	COG3776	membrane
HV197_RS01480	COG0742	ribosomal rna small subunit methyltransferase
HV197_RS01485	COG0552	protein localization to endoplasmic reticulum
HV197_RS01490	COG2884	Cell division ATP-binding protein ftsE
HV197_RS01495	COG2177	Part of the ABC transporter FtsEX involved in
HV197_RS01510	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV197_RS01520	COG0683	leucine binding
HV197_RS01530	COG0683	leucine binding
HV197_RS01535	COG0559	Belongs to the binding-protein-dependent transport system permease family
HV197_RS01585	COG0584	glycerophosphoryl diester phosphodiesterase
HV197_RS01595	COG0405	Gamma-glutamyltransferase
HV197_RS01600	COG1247	-acetyltransferase
HV197_RS01610	COG0673	inositol 2-dehydrogenase activity
HV197_RS01615	COG1741	Belongs to the pirin family
HV197_RS01620	COG1609	Transcriptional regulator
HV197_RS01625	COG3265	gluconokinase activity
HV197_RS01630	COG2610	gluconate transmembrane transporter activity
HV197_RS01640	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HV197_RS01665	COG0058	SHG alpha-glucan phosphorylase activity
HV197_RS01680	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HV197_RS01695	COG1349	DNA-binding transcription factor activity
HV197_RS01705	COG0058	SHG alpha-glucan phosphorylase activity
HV197_RS01710	COG1640	4-alpha-glucanotransferase
HV197_RS01715	COG2610	gluconate transmembrane transporter activity
HV197_RS01725	COG1040	competence protein
HV197_RS01750	COG1918	ferrous iron import across plasma membrane
HV197_RS01755	COG2183	response to ionizing radiation
HV197_RS01760	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HV197_RS01765	COG0745	RESPONSE REGULATOR receiver
HV197_RS01785	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HV197_RS01790	COG1011	Hydrolase
HV197_RS01800	COG0494	nUDIX hydrolase
HV197_RS01805	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HV197_RS01830	COG4796	Type ii and iii secretion system protein
HV197_RS01845	COG3266	domain, Protein
HV197_RS01850	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HV197_RS01855	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HV197_RS01880	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HV197_RS01885	COG0402	S-adenosylhomocysteine deaminase activity
HV197_RS01890	COG0738	Major facilitator superfamily
HV197_RS01915	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HV197_RS01920	COG1289	transmembrane transporter activity
HV197_RS01930	COG1765	OsmC-like protein
HV197_RS01935	COG3954	Phosphoribulokinase
HV197_RS01945	COG0429	hydrolase of the alpha beta-hydrolase fold
HV197_RS01950	COG0488	(ABC) transporter
HV197_RS01965	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HV197_RS01970	COG1047	Peptidyl-prolyl cis-trans
HV197_RS01980	COG0545	Peptidyl-prolyl cis-trans isomerase
HV197_RS01985	COG2964	Protein conserved in bacteria
HV197_RS02040	COG0051	transcription antitermination factor activity, RNA binding
HV197_RS02065	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HV197_RS02080	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HV197_RS02145	COG0201	protein transport
HV197_RS02170	COG0202	RNA polymerase activity
HV197_RS02185	COG0789	Transcriptional regulator
HV197_RS02190	COG3036	rescue of stalled ribosome
HV197_RS02220	COG0758	DNA mediated transformation
HV197_RS02230	COG0551	DNA topoisomerase type I activity
HV197_RS02250	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV197_RS02285	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV197_RS02290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV197_RS02295	COG1309	transcriptional regulator
HV197_RS02315	COG4145	pantothenate transmembrane transporter activity
HV197_RS02320	COG3924	membrane
HV197_RS02325	COG0439	Biotin carboxylase
HV197_RS02330	COG0511	ligase activity, forming carbon-carbon bonds
HV197_RS02355	COG2199	diguanylate cyclase activity
HV197_RS02355	COG2200	EAL domain
HV197_RS02360	COG1077	Cell shape determining protein MreB Mrl
HV197_RS02365	COG1792	Involved in formation and maintenance of cell shape
HV197_RS02370	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HV197_RS02380	COG1530	ribonuclease E activity
HV197_RS02385	COG3164	Protein of unknown function
HV197_RS02390	COG0312	modulator of DNA gyrase
HV197_RS02395	COG0583	DNA-binding transcription factor activity
HV197_RS02410	COG1289	transmembrane transporter activity
HV197_RS02415	COG2732	(Barnase) inhibitor
HV197_RS02440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV197_RS02445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV197_RS02450	COG3105	Protein conserved in bacteria
HV197_RS02455	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HV197_RS02475	COG0625	glutathione transferase activity
HV197_RS02480	COG2969	positive regulation of protein catabolic process
HV197_RS02490	COG0493	'glutamate synthase
HV197_RS02495	COG0067	glutamate synthase
HV197_RS02495	COG0070	glutamate synthase
HV197_RS02495	COG0069	glutamate synthase activity
HV197_RS02500	COG1242	4 iron, 4 sulfur cluster binding
HV197_RS02505	COG2271	Major facilitator Superfamily
HV197_RS02510	COG1063	alcohol dehydrogenase
HV197_RS02515	COG1312	Catalyzes the dehydration of D-mannonate
HV197_RS02520	COG5002	protein histidine kinase activity
HV197_RS02520	COG2198	Histidine kinase
HV197_RS02520	COG0784	Response regulator, receiver
HV197_RS02525	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HV197_RS02530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HV197_RS02535	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV197_RS02545	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV197_RS02550	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HV197_RS02555	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HV197_RS02560	COG1137	ATPase activity
HV197_RS02565	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HV197_RS02570	COG3117	lipopolysaccharide transmembrane transporter activity
HV197_RS02575	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HV197_RS02585	COG0530	calcium, potassium:sodium antiporter activity
HV197_RS02590	COG1127	ABC transporter
HV197_RS02595	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HV197_RS02600	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HV197_RS02605	COG2854	intermembrane phospholipid transfer
HV197_RS02610	COG3113	response to antibiotic
HV197_RS02615	COG5007	Belongs to the BolA IbaG family
HV197_RS02625	COG3423	Transcriptional regulator
HV197_RS02630	COG0142	geranyltranstransferase activity
HV197_RS02645	COG0697	spore germination
HV197_RS02655	COG2027	D-alanyl-D-alanine carboxypeptidase
HV197_RS02665	COG1534	Rna-binding protein
HV197_RS02675	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HV197_RS02680	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HV197_RS02690	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HV197_RS02730	COG0195	Participates in both transcription termination and antitermination
HV197_RS02775	COG0814	amino acid
HV197_RS02780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV197_RS02785	COG0826	peptidase U32
HV197_RS02790	COG0826	peptidase U32
HV197_RS02795	COG3154	lipid carrier protein
HV197_RS02800	COG3153	acetyltransferase
HV197_RS02815	COG0693	protein deglycase activity
HV197_RS02820	COG0702	epimerase
HV197_RS02825	COG0701	Predicted permease
HV197_RS02830	COG2823	Periplasmic or secreted lipoprotein
HV197_RS02850	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HV197_RS02855	COG2721	sulfolactate sulfo-lyase activity
HV197_RS02860	COG2271	Major facilitator Superfamily
HV197_RS02870	COG2084	Dehydrogenase
HV197_RS02875	COG1929	Belongs to the glycerate kinase type-1 family
HV197_RS02900	COG1741	Belongs to the pirin family
HV197_RS02905	COG0583	DNA-binding transcription factor activity
HV197_RS02910	COG3152	Membrane
HV197_RS02915	COG0435	Glutathione S-transferase
HV197_RS02920	COG2259	Doxx family
HV197_RS02930	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HV197_RS02935	COG4575	ribosome binding
HV197_RS02940	COG1422	Protein of unknown function (DUF1090)
HV197_RS02950	COG0586	Pfam SNARE associated Golgi protein
HV197_RS02955	COG2186	Transcriptional regulator
HV197_RS02960	COG2271	Major facilitator Superfamily
HV197_RS02970	COG2721	sulfolactate sulfo-lyase activity
HV197_RS02985	COG0861	Integral membrane protein TerC family
HV197_RS02990	COG0673	inositol 2-dehydrogenase activity
HV197_RS02995	COG1451	nucleotide metabolic process
HV197_RS03015	COG0446	pyridine nucleotide-disulphide oxidoreductase
HV197_RS03015	COG1902	pentaerythritol trinitrate reductase activity
HV197_RS03065	COG1695	Transcriptional regulator
HV197_RS03070	COG2375	cellular response to nickel ion
HV197_RS03085	COG1461	Dihydroxyacetone kinase
HV197_RS03090	COG2376	Dihydroxyacetone kinase
HV197_RS03160	COG3247	response to pH
HV197_RS03170	COG0784	Response regulator, receiver
HV197_RS03170	COG2198	Histidine kinase
HV197_RS03170	COG2205	protein histidine kinase activity
HV197_RS03170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV197_RS03175	COG2197	response regulator
HV197_RS03200	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HV197_RS03205	COG0358	DNA primase activity
HV197_RS03210	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HV197_RS03275	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HV197_RS03290	COG4991	sh3 domain protein
HV197_RS03295	COG3025	triphosphatase activity
HV197_RS03320	COG2960	long-chain fatty acid transporting porin activity
HV197_RS03335	COG3384	dioxygenase
HV197_RS03340	COG0754	glutathionylspermidine amidase activity
HV197_RS03355	COG0494	nUDIX hydrolase
HV197_RS03360	COG3151	Protein conserved in bacteria
HV197_RS03365	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HV197_RS03370	COG3150	esterase
HV197_RS03380	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HV197_RS03385	COG2249	NAD(P)H dehydrogenase (quinone) activity
HV197_RS03390	COG0642	Histidine kinase
HV197_RS03400	COG3111	PFAM Bacterial OB fold (BOF) protein
HV197_RS03405	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HV197_RS03410	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HV197_RS03415	COG0204	Acyl-transferase
HV197_RS03420	COG2132	Multicopper oxidase
HV197_RS03425	COG1032	radical SAM domain protein
HV197_RS03435	COG0656	L-ascorbic acid biosynthetic process
HV197_RS03440	COG1979	alcohol dehydrogenase
HV197_RS03445	COG2207	Transcriptional regulator
HV197_RS03450	COG0586	Pfam SNARE associated Golgi protein
HV197_RS03455	COG0626	cystathionine gamma-synthase activity
HV197_RS03465	COG0848	biopolymer transport protein
HV197_RS03470	COG2211	Major facilitator Superfamily
HV197_RS03495	COG0625	glutathione transferase activity
HV197_RS03510	COG0754	glutathionylspermidine amidase activity
HV197_RS03515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV197_RS03535	COG0583	DNA-binding transcription factor activity
HV197_RS03540	COG0626	cystathionine gamma-synthase activity
HV197_RS03575	COG1811	Na channel or pump
HV197_RS03580	COG1982	Orn Lys Arg decarboxylase major
HV197_RS03585	COG2211	Major facilitator Superfamily
HV197_RS03600	COG1194	a g-specific adenine glycosylase
HV197_RS03610	COG3171	Protein conserved in bacteria
HV197_RS03625	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HV197_RS03625	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HV197_RS03630	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HV197_RS03635	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HV197_RS03650	COG0762	integral membrane protein
HV197_RS03655	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HV197_RS03660	COG2805	Type II/IV secretion system protein
HV197_RS03680	COG0189	ligase activity
HV197_RS03685	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HV197_RS03690	COG2356	endonuclease I
HV197_RS03700	COG2814	Major facilitator Superfamily
HV197_RS03735	COG2146	nitrite reductase [NAD(P)H] activity
HV197_RS03750	COG1028	Short-chain dehydrogenase reductase Sdr
HV197_RS03755	COG1414	Transcriptional regulator
HV197_RS03785	COG1028	Short-chain dehydrogenase reductase Sdr
HV197_RS03790	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
HV197_RS03810	COG0501	Belongs to the peptidase M48B family
HV197_RS03815	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV197_RS03830	COG0191	fructose-bisphosphate aldolase activity
HV197_RS03835	COG0668	transmembrane transport
HV197_RS03845	COG2968	Membrane
HV197_RS03860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV197_RS03865	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HV197_RS03885	COG0006	proline dipeptidase activity
HV197_RS03890	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV197_RS03895	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV197_RS03915	COG1028	Short-chain dehydrogenase reductase Sdr
HV197_RS03920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HV197_RS03940	COG2723	6-phospho-beta-galactosidase activity
HV197_RS03945	COG1737	Transcriptional regulator
HV197_RS03955	COG1272	protein, Hemolysin III
HV197_RS03965	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HV197_RS03975	COG0716	FMN binding
HV197_RS03980	COG4974	Belongs to the 'phage' integrase family
HV197_RS03990	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HV197_RS04010	COG4942	peptidase
HV197_RS04035	COG0582	viral genome integration into host DNA
HV197_RS04105	COG2814	Major facilitator Superfamily
HV197_RS04120	COG0667	Aldo Keto reductase
HV197_RS04160	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HV197_RS04165	COG1393	Belongs to the ArsC family
HV197_RS04170	COG3104	oligopeptide transport
HV197_RS04180	COG1538	Outer membrane efflux protein
HV197_RS04185	COG1289	transmembrane transporter activity
HV197_RS04200	COG3592	Divergent 4Fe-4S mono-cluster
HV197_RS04205	COG2388	GCN5-related N-acetyl-transferase
HV197_RS04215	COG3539	Fimbrial protein
HV197_RS04220	COG3539	Fimbrial protein
HV197_RS04225	COG3539	Fimbrial protein
HV197_RS04230	COG3188	usher protein
HV197_RS04235	COG3121	Chaperone
HV197_RS04240	COG3539	Fimbrial protein
HV197_RS04250	COG4974	Belongs to the 'phage' integrase family
HV197_RS04255	COG0582	viral genome integration into host DNA
HV197_RS04260	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HV197_RS04265	COG1846	Transcriptional regulator
HV197_RS04270	COG0697	spore germination
HV197_RS04320	COG0667	Aldo Keto reductase
HV197_RS04325	COG0814	amino acid
HV197_RS04340	COG0183	Belongs to the thiolase family
HV197_RS04350	COG0823	Involved in the tonB-independent uptake of proteins
HV197_RS04355	COG1028	Short-chain dehydrogenase reductase Sdr
HV197_RS04360	COG2814	Major facilitator Superfamily
HV197_RS04395	COG3842	ATPase activity
HV197_RS04405	COG1175	transmembrane transport
HV197_RS04410	COG1917	Cupin 2, conserved barrel domain protein
HV197_RS04415	COG1794	racemase activity, acting on amino acids and derivatives
HV197_RS04420	COG0583	DNA-binding transcription factor activity
HV197_RS04430	COG1609	Transcriptional regulator
HV197_RS04435	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV197_RS04440	COG2723	6-phospho-beta-galactosidase activity
HV197_RS04445	COG2186	Transcriptional regulator
HV197_RS04455	COG1609	Transcriptional regulator
HV197_RS04470	COG0667	Aldo Keto reductase
HV197_RS04480	COG0861	Integral membrane protein TerC family
HV197_RS04515	COG2165	general secretion pathway protein
HV197_RS04520	COG4795	General secretion pathway protein
HV197_RS04530	COG4967	type IV pilus modification protein PilV
HV197_RS04535	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HV197_RS04540	COG1025	Belongs to the peptidase M16 family
HV197_RS04545	COG1074	ATP-dependent DNA helicase activity
HV197_RS04550	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HV197_RS04560	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HV197_RS04560	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HV197_RS04565	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV197_RS04570	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HV197_RS04600	COG4656	Part of a membrane complex involved in electron transport
HV197_RS04605	COG1012	belongs to the aldehyde dehydrogenase family
HV197_RS04605	COG1454	alcohol dehydrogenase
HV197_RS04800	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HV197_RS04805	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HV197_RS04810	COG2166	iron-sulfur cluster assembly
HV197_RS04815	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HV197_RS04825	COG0583	DNA-binding transcription factor activity
HV197_RS04830	COG2363	Small membrane protein
HV197_RS04840	COG1349	DNA-binding transcription factor activity
HV197_RS04860	COG0738	Major facilitator superfamily
HV197_RS04865	COG0235	Class ii aldolase
HV197_RS04870	COG1454	alcohol dehydrogenase
HV197_RS04890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV197_RS04905	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HV197_RS04910	COG2011	ABC-type metal ion transport system permease component
HV197_RS04915	COG1464	Belongs to the NlpA lipoprotein family
HV197_RS04920	COG0477	Major facilitator Superfamily
HV197_RS04930	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HV197_RS04935	COG1760	l-serine dehydratase
HV197_RS04940	COG0814	amino acid
HV197_RS04945	COG1611	Belongs to the LOG family
HV197_RS04960	COG3098	single-species biofilm formation
HV197_RS04965	COG0564	pseudouridine synthase activity
HV197_RS04970	COG0716	FMN binding
HV197_RS04975	COG2271	Major facilitator Superfamily
HV197_RS04980	COG4948	Mandelate Racemase Muconate Lactonizing
HV197_RS04985	COG4948	Mandelate Racemase Muconate Lactonizing
HV197_RS04990	COG1929	Belongs to the glycerate kinase type-1 family
HV197_RS04995	COG2205	protein histidine kinase activity
HV197_RS04995	COG3437	response regulator, receiver
HV197_RS04995	COG3850	Histidine kinase
HV197_RS04995	COG4999	Histidine kinase
HV197_RS05005	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV197_RS05010	COG3956	TIGRFAM MazG family protein
HV197_RS05030	COG0602	queuosine metabolic process
HV197_RS05035	COG0720	synthase
HV197_RS05055	COG2234	aminopeptidase activity
HV197_RS05115	COG1388	LysM domain
HV197_RS05115	COG4942	peptidase
HV197_RS05120	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HV197_RS05145	COG0163	prenyltransferase activity
HV197_RS05150	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HV197_RS05175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV197_RS05180	COG4558	Periplasmic binding protein
HV197_RS05185	COG3720	iron ion transport
HV197_RS05205	COG0679	Auxin Efflux Carrier
HV197_RS05220	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV197_RS05225	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV197_RS05230	COG1121	(ABC) transporter
HV197_RS05240	COG1609	Transcriptional regulator
HV197_RS05245	COG1940	carbohydrate kinase activity
HV197_RS05250	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV197_RS05255	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV197_RS05260	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV197_RS05265	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV197_RS05270	COG4580	involved in the transport of maltose and maltodextrins
HV197_RS05280	COG2723	6-phospho-beta-galactosidase activity
HV197_RS05290	COG0309	Hydrogenase expression formation protein (HypE)
HV197_RS05295	COG0409	Hydrogenase expression formation protein
HV197_RS05300	COG0298	carbon dioxide binding
HV197_RS05305	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HV197_RS05320	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV197_RS05325	COG0651	ATP synthesis coupled electron transport
HV197_RS05330	COG0650	Formate hydrogenlyase subunit 4
HV197_RS05335	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HV197_RS05335	COG3261	NADH dehydrogenase
HV197_RS05340	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV197_RS05345	COG3260	NADH ubiquinone oxidoreductase 20
HV197_RS05355	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HV197_RS05365	COG2723	6-phospho-beta-galactosidase activity
HV197_RS05370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV197_RS05370	COG1263	PTS System
HV197_RS05375	COG1609	Transcriptional regulator
HV197_RS05380	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV197_RS05385	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HV197_RS05390	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HV197_RS05415	COG1349	DNA-binding transcription factor activity
HV197_RS05420	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV197_RS05425	COG1028	Short-chain dehydrogenase reductase Sdr
HV197_RS05435	COG3732	PTS system glucitol sorbitol-specific
HV197_RS05440	COG3730	PTS system glucitol sorbitol-specific
HV197_RS05445	COG2951	lytic endotransglycosylase activity
HV197_RS05450	COG1121	(ABC) transporter
HV197_RS05455	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV197_RS05465	COG1546	Belongs to the CinA family
HV197_RS05485	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HV197_RS05515	COG2823	Periplasmic or secreted lipoprotein
HV197_RS05520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV197_RS05525	COG1238	metal cluster binding
HV197_RS05545	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HV197_RS05550	COG2814	Major facilitator Superfamily
HV197_RS05555	COG1566	PFAM secretion protein HlyD family protein
HV197_RS05560	COG1846	Transcriptional regulator
HV197_RS05570	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HV197_RS05580	COG4176	ABC-type proline glycine betaine transport system permease component
HV197_RS05595	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HV197_RS05605	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HV197_RS05610	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV197_RS05615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV197_RS05620	COG4575	ribosome binding
HV197_RS05635	COG2916	Histone family protein nucleoid-structuring protein H-NS
HV197_RS05650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV197_RS05655	COG0640	Transcriptional regulator
HV197_RS05665	COG0583	DNA-binding transcription factor activity
HV197_RS05670	COG3284	Transcriptional regulator
HV197_RS05675	COG1012	belongs to the aldehyde dehydrogenase family
HV197_RS05680	COG3539	Fimbrial protein
HV197_RS05685	COG3121	Chaperone
HV197_RS05705	COG3188	usher protein
HV197_RS05715	COG3539	Fimbrial protein
HV197_RS05720	COG2197	response regulator
HV197_RS05735	COG1028	Short-chain dehydrogenase reductase Sdr
HV197_RS05745	COG0235	Class ii aldolase
HV197_RS05755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV197_RS05790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV197_RS05795	COG3708	Transcriptional regulator
HV197_RS05795	COG2207	Transcriptional regulator
HV197_RS05825	COG2867	negative regulation of translational initiation
HV197_RS05840	COG0497	DNA recombination
HV197_RS05855	COG4536	flavin adenine dinucleotide binding
HV197_RS05860	COG4137	Cytochrome C assembly protein
HV197_RS05865	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HV197_RS05900	COG2885	chlorophyll binding
HV197_RS05905	COG2199	diguanylate cyclase activity
HV197_RS05915	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV197_RS05920	COG1605	Chorismate mutase
HV197_RS05920	COG0287	Prephenate dehydrogenase
HV197_RS05930	COG1605	Chorismate mutase
HV197_RS05930	COG0077	Prephenate dehydratase
HV197_RS05940	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HV197_RS05945	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV197_RS05960	COG0542	response to heat
HV197_RS05985	COG0477	Major facilitator Superfamily
HV197_RS05990	COG5544	Lipoprotein
HV197_RS05995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV197_RS06010	COG3118	belongs to the thioredoxin family
HV197_RS06015	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV197_RS06030	COG0513	Belongs to the DEAD box helicase family
HV197_RS06040	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HV197_RS06055	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HV197_RS06060	COG3026	antisigma factor binding
HV197_RS06065	COG3086	response to oxidative stress
HV197_RS06075	COG0681	Belongs to the peptidase S26 family
HV197_RS06095	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HV197_RS06105	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV197_RS06110	COG1737	Transcriptional regulator
HV197_RS06115	COG0560	Phosphoserine phosphatase
HV197_RS06130	COG0047	phosphoribosylformylglycinamidine synthase activity
HV197_RS06130	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HV197_RS06135	COG2205	protein histidine kinase activity
HV197_RS06140	COG3170	Tfp pilus assembly protein FimV
HV197_RS06145	COG2204	response regulator
HV197_RS06150	COG0347	Belongs to the P(II) protein family
HV197_RS06155	COG1017	nitric oxide dioxygenase activity
HV197_RS06155	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV197_RS06165	COG2259	Doxx family
HV197_RS06170	COG1940	carbohydrate kinase activity
HV197_RS06175	COG0457	Tetratricopeptide repeat
HV197_RS06180	COG2814	Major facilitator Superfamily
HV197_RS06180	COG0477	Major facilitator Superfamily
HV197_RS06185	COG2017	converts alpha-aldose to the beta-anomer
HV197_RS06190	COG2814	Major facilitator Superfamily
HV197_RS06195	COG3711	transcriptional antiterminator
HV197_RS06200	COG3683	transport system, periplasmic component
HV197_RS06205	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HV197_RS06235	COG0822	iron-sulfur transferase activity
HV197_RS06255	COG0633	Ferredoxin
HV197_RS06260	COG2975	iron-sulfur cluster assembly
HV197_RS06280	COG2897	thiosulfate sulfurtransferase activity
HV197_RS06285	COG2373	Large extracellular alpha-helical protein
HV197_RS06290	COG4953	penicillin-binding protein 1C
HV197_RS06320	COG2976	Protein conserved in bacteria
HV197_RS06350	COG1645	bacterial-type flagellum-dependent swarming motility
HV197_RS06360	COG0517	IMP dehydrogenase activity
HV197_RS06360	COG0516	GMP reductase activity
HV197_RS06370	COG3119	arylsulfatase activity
HV197_RS06375	COG0641	radical SAM
HV197_RS06395	COG2200	EAL domain
HV197_RS06410	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HV197_RS06425	COG2723	6-phospho-beta-galactosidase activity
HV197_RS06435	COG2233	PERMEase
HV197_RS06450	COG1393	Belongs to the ArsC family
HV197_RS06455	COG4783	chaperone-mediated protein folding
HV197_RS06465	COG0628	permease
HV197_RS06470	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HV197_RS06475	COG2716	regulation of RNA biosynthetic process
HV197_RS06485	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HV197_RS06495	COG2321	neutral zinc metallopeptidase
HV197_RS06500	COG1444	tRNA N-acetyltransferase activity
HV197_RS06505	COG0400	carboxylic ester hydrolase activity
HV197_RS06520	COG1393	Belongs to the ArsC family
HV197_RS06530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV197_RS06535	COG0493	'glutamate synthase
HV197_RS06535	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV197_RS06545	COG5342	invasion associated locus B
HV197_RS06550	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV197_RS06555	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HV197_RS06565	COG4810	utilization protein
HV197_RS06655	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV197_RS06675	COG2837	iron assimilation
HV197_RS06685	COG4150	thiosulfate binding
HV197_RS06690	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HV197_RS06695	COG4208	sulfate ABC transporter
HV197_RS06700	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HV197_RS06710	COG4319	ketosteroid isomerase
HV197_RS06745	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HV197_RS06765	COG3530	Putative quorum-sensing-regulated virulence factor
HV197_RS06770	COG0385	Bile acid
HV197_RS06775	COG0583	DNA-binding transcription factor activity
HV197_RS06810	COG3415	Transposase
HV197_RS06815	COG3415	Transposase
HV197_RS06830	COG2199	diguanylate cyclase activity
HV197_RS06830	COG2200	EAL domain
HV197_RS06835	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV197_RS06850	COG0667	Aldo Keto reductase
HV197_RS06855	COG3961	Belongs to the TPP enzyme family
HV197_RS06870	COG3279	Response regulator of the LytR AlgR family
HV197_RS06875	COG3275	phosphorelay sensor kinase activity
HV197_RS06890	COG0436	Aminotransferase
HV197_RS06900	COG2807	transmembrane transport
HV197_RS06905	COG0590	tRNA wobble adenosine to inosine editing
HV197_RS06910	COG0583	DNA-binding transcription factor activity
HV197_RS06930	COG2116	formate transmembrane transporter activity
HV197_RS06935	COG2853	Lipoprotein
HV197_RS06945	COG3691	Protein conserved in bacteria
HV197_RS06960	COG2062	phosphohistidine phosphatase, SixA
HV197_RS06985	COG0730	response to heat
HV197_RS06990	COG3101	peptidyl-lysine hydroxylation
HV197_RS07005	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV197_RS07025	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HV197_RS07035	COG0586	Pfam SNARE associated Golgi protein
HV197_RS07045	COG0285	dihydrofolate synthase activity
HV197_RS07050	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HV197_RS07055	COG1286	toxin biosynthetic process
HV197_RS07060	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HV197_RS07065	COG0163	prenyltransferase activity
HV197_RS07090	COG4160	amino acid transport
HV197_RS07095	COG4598	ABC transporter
HV197_RS07110	COG1090	epimerase
HV197_RS07115	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HV197_RS07120	COG0625	glutathione transferase activity
HV197_RS07125	COG0625	glutathione transferase activity
HV197_RS07130	COG0622	Phosphoesterase
HV197_RS07135	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HV197_RS07140	COG0857	belongs to the CobB CobQ family
HV197_RS07140	COG0280	phosphate acetyltransferase
HV197_RS07160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV197_RS07165	COG0490	domain, Protein
HV197_RS07165	COG0471	metal ion transport
HV197_RS07175	COG0436	Aminotransferase
HV197_RS07180	COG0583	DNA-binding transcription factor activity
HV197_RS07225	COG0839	Belongs to the complex I subunit 6 family
HV197_RS07235	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HV197_RS07240	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV197_RS07255	COG2153	protein acetylation
HV197_RS07260	COG1169	isochorismate synthase
HV197_RS07285	COG0318	PFAM AMP-dependent synthetase and ligase
HV197_RS07295	COG5464	transposase or invertase
HV197_RS07310	COG1414	Transcriptional regulator
HV197_RS07320	COG2271	Major facilitator Superfamily
HV197_RS07330	COG0247	lactate metabolic process
HV197_RS07340	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HV197_RS07345	COG2271	Major facilitator Superfamily
HV197_RS07350	COG0584	glycerophosphoryl diester phosphodiesterase
HV197_RS07355	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV197_RS07380	COG2205	protein histidine kinase activity
HV197_RS07380	COG0784	Response regulator, receiver
HV197_RS07390	COG0642	Histidine kinase
HV197_RS07390	COG2198	Histidine kinase
HV197_RS07405	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HV197_RS07405	COG2169	Transcriptional regulator
HV197_RS07410	COG3145	DNA-N1-methyladenine dioxygenase activity
HV197_RS07415	COG4615	Cyclic peptide transporter
HV197_RS07420	COG2239	Acts as a magnesium transporter
HV197_RS07425	COG0659	secondary active sulfate transmembrane transporter activity
HV197_RS07440	COG0628	permease
HV197_RS07465	COG1349	DNA-binding transcription factor activity
HV197_RS07470	COG0494	nUDIX hydrolase
HV197_RS07490	COG1061	Type III restriction enzyme res subunit
HV197_RS07495	COG1187	pseudouridine synthase activity
HV197_RS07500	COG2814	Major facilitator Superfamily
HV197_RS07510	COG4172	Belongs to the ABC transporter superfamily
HV197_RS07515	COG4239	(ABC) transporter, permease
HV197_RS07520	COG4174	ABC transporter (Permease)
HV197_RS07525	COG4166	transmembrane transport
HV197_RS07530	COG2200	EAL domain
HV197_RS07535	COG0791	NLP P60 protein
HV197_RS07540	COG0671	phosphoesterase, PA-phosphatase related
HV197_RS07545	COG0523	cobalamin synthesis protein
HV197_RS07550	COG0246	Mannitol dehydrogenase
HV197_RS07555	COG1312	Catalyzes the dehydration of D-mannonate
HV197_RS07575	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV197_RS07575	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV197_RS07580	COG1105	Belongs to the carbohydrate kinase PfkB family
HV197_RS07585	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV197_RS07585	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HV197_RS07585	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV197_RS07595	COG2855	membrane
HV197_RS07600	COG0583	DNA-binding transcription factor activity
HV197_RS07605	COG0833	amino acid
HV197_RS07610	COG4771	TonB-dependent receptor
HV197_RS07625	COG2311	Membrane
HV197_RS07640	COG1129	ABC transporter
HV197_RS07650	COG2949	membrane
HV197_RS07660	COG1346	cytolysis
HV197_RS07670	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HV197_RS07675	COG3659	wide pore channel activity
HV197_RS07690	COG2723	6-phospho-beta-galactosidase activity
HV197_RS07695	COG1538	Outer membrane efflux protein
HV197_RS07700	COG0586	Pfam SNARE associated Golgi protein
HV197_RS07710	COG1686	Belongs to the peptidase S11 family
HV197_RS07720	COG0277	FAD linked oxidase domain protein
HV197_RS07725	COG1472	Belongs to the glycosyl hydrolase 3 family
HV197_RS07730	COG1732	Glycine betaine
HV197_RS07735	COG1174	glycine betaine transport
HV197_RS07740	COG1125	glycine betaine transport
HV197_RS07745	COG1174	glycine betaine transport
HV197_RS07755	COG3275	phosphorelay sensor kinase activity
HV197_RS07765	COG4807	Protein conserved in bacteria
HV197_RS07785	COG5455	response to cobalt ion
HV197_RS07790	COG0583	DNA-binding transcription factor activity
HV197_RS07795	COG2252	PERMEase
HV197_RS07805	COG0583	DNA-binding transcription factor activity
HV197_RS07820	COG0351	phosphomethylpyrimidine kinase
HV197_RS07825	COG1830	Aldolase
HV197_RS07860	COG1070	Carbohydrate kinase
HV197_RS07870	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV197_RS07875	COG4948	Mandelate Racemase Muconate Lactonizing
HV197_RS07880	COG0747	negative chemotaxis
HV197_RS07885	COG0601	transmembrane transport
HV197_RS07895	COG0444	Belongs to the ABC transporter superfamily
HV197_RS07900	COG4608	Belongs to the ABC transporter superfamily
HV197_RS07915	COG0745	RESPONSE REGULATOR receiver
HV197_RS07920	COG2205	protein histidine kinase activity
HV197_RS07945	COG1301	dicarboxylic acid transport
HV197_RS07965	COG2205	protein histidine kinase activity
HV197_RS07970	COG0443	Heat shock 70 kDa protein
HV197_RS07975	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HV197_RS07990	COG2982	Protein involved in outer membrane biogenesis
HV197_RS07995	COG1253	flavin adenine dinucleotide binding
HV197_RS08035	COG5039	Polysaccharide pyruvyl transferase
HV197_RS08140	COG0438	transferase activity, transferring glycosyl groups
HV197_RS08145	COG1442	glycosyl transferase family 8
HV197_RS08145	COG1216	Glycosyl transferase, family 2
HV197_RS08155	COG0463	Glycosyl transferase, family 2
HV197_RS08180	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HV197_RS08210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV197_RS08215	COG0583	DNA-binding transcription factor activity
HV197_RS08225	COG0531	amino acid
HV197_RS08230	COG0640	Transcriptional regulator
HV197_RS08235	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HV197_RS08240	COG2925	Exonuclease
HV197_RS08255	COG1289	transmembrane transporter activity
HV197_RS08275	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HV197_RS08285	COG1942	4-Oxalocrotonate Tautomerase
HV197_RS08290	COG0583	DNA-binding transcription factor activity
HV197_RS08295	COG0095	Lipoate-protein ligase
HV197_RS08300	COG0477	Major facilitator Superfamily
HV197_RS08310	COG5001	Diguanylate cyclase
HV197_RS08310	COG3300	MHYT domain
HV197_RS08320	COG3615	Tellurite resistance protein tehB
HV197_RS08345	COG3706	GGDEF domain
HV197_RS08365	COG0534	Mate efflux family protein
HV197_RS08375	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HV197_RS08395	COG0604	alcohol dehydrogenase
HV197_RS08400	COG1309	transcriptional regulator
HV197_RS08405	COG0025	NhaP-type Na H and K H
HV197_RS08455	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV197_RS08465	COG1418	mRNA catabolic process
HV197_RS08470	COG0270	DNA (cytosine-5-)-methyltransferase activity
HV197_RS08475	COG3727	T/G mismatch-specific endonuclease activity
HV197_RS08480	COG0697	spore germination
HV197_RS08485	COG2354	Protein conserved in bacteria
HV197_RS08515	COG0366	Alpha amylase catalytic
HV197_RS08540	COG2197	response regulator
HV197_RS08550	COG2197	response regulator
HV197_RS08585	COG3318	Belongs to the UPF0149 family
HV197_RS08585	COG3012	SEC-C Motif Domain Protein
HV197_RS08590	COG0814	amino acid
HV197_RS08600	COG1528	Iron-storage protein
HV197_RS08615	COG0477	Major facilitator Superfamily
HV197_RS08625	COG2211	Major facilitator Superfamily
HV197_RS08635	COG1528	Iron-storage protein
HV197_RS08645	COG1879	ABC-type sugar transport system periplasmic component
HV197_RS08655	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV197_RS08680	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HV197_RS08690	COG3102	Protein conserved in bacteria
HV197_RS08710	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HV197_RS08715	COG1801	Protein of unknown function DUF72
HV197_RS08720	COG1335	isochorismatase
HV197_RS08730	COG0494	nUDIX hydrolase
HV197_RS08755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV197_RS08765	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HV197_RS08770	COG0739	heme binding
HV197_RS08775	COG1560	Kdo2-lipid A biosynthetic process
HV197_RS08785	COG1737	Transcriptional regulator
HV197_RS08795	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HV197_RS08800	COG0129	dihydroxy-acid dehydratase activity
HV197_RS08805	COG0800	Aldolase
HV197_RS08815	COG3141	response to X-ray
HV197_RS08820	COG2979	Protein of unknown function (DUF533)
HV197_RS08825	COG1770	oligopeptidase
HV197_RS08830	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV197_RS08840	COG2372	response to copper ion
HV197_RS08845	COG1276	copper resistance
HV197_RS08860	COG2990	Protein conserved in bacteria
HV197_RS08885	COG3008	intermembrane lipid transfer
HV197_RS08890	COG2995	paraquat-inducible protein a
HV197_RS08895	COG1956	GAF domain-containing protein
HV197_RS08915	COG2814	Major facilitator Superfamily
HV197_RS08920	COG1414	Transcriptional regulator
HV197_RS08950	COG0768	penicillin binding
HV197_RS08955	COG2226	methyltransferase
HV197_RS08970	COG3716	PTS system mannose fructose sorbose family IID component
HV197_RS08975	COG3715	PTS system
HV197_RS08980	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV197_RS08980	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV197_RS08985	COG1253	flavin adenine dinucleotide binding
HV197_RS08990	COG2200	EAL domain
HV197_RS08995	COG1760	l-serine dehydratase
HV197_RS09015	COG0251	oxidation-reduction process
HV197_RS09020	COG1199	ATP-dependent helicase activity
HV197_RS09030	COG3065	identical protein binding
HV197_RS09040	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HV197_RS09050	COG2894	cell division
HV197_RS09065	COG0179	Fumarylacetoacetate (FAA) hydrolase
HV197_RS09095	COG2719	SpoVR family
HV197_RS09120	COG1619	proteins homologs of microcin C7 resistance protein MccF
HV197_RS09130	COG4774	siderophore transport
HV197_RS09145	COG2308	Evidence 4 Homologs of previously reported genes of
HV197_RS09185	COG0583	DNA-binding transcription factor activity
HV197_RS09190	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HV197_RS09205	COG1882	Formate acetyltransferase
HV197_RS09240	COG0583	DNA-binding transcription factor activity
HV197_RS09270	COG0583	DNA-binding transcription factor activity
HV197_RS09285	COG3122	Protein conserved in bacteria
HV197_RS09305	COG2885	chlorophyll binding
HV197_RS09315	COG3501	Rhs element vgr protein
HV197_RS09320	COG1388	LysM domain
HV197_RS09380	COG0012	GTP binding
HV197_RS09400	COG0659	secondary active sulfate transmembrane transporter activity
HV197_RS09430	COG2890	protein-(glutamine-N5) methyltransferase activity
HV197_RS09450	COG0387	Pfam Sodium calcium exchanger
HV197_RS09455	COG4572	Cation transport regulator
HV197_RS09460	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HV197_RS09470	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HV197_RS09475	COG3707	response regulator
HV197_RS09480	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HV197_RS09490	COG1116	anion transmembrane transporter activity
HV197_RS09495	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HV197_RS09495	COG2146	nitrite reductase [NAD(P)H] activity
HV197_RS09500	COG0243	molybdopterin cofactor binding
HV197_RS09505	COG4932	domain protein
HV197_RS09510	COG2197	response regulator
HV197_RS09515	COG3850	Histidine kinase
HV197_RS09520	COG2223	nitrite transmembrane transporter activity
HV197_RS09530	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HV197_RS09535	COG1140	nitrate reductase beta subunit
HV197_RS09540	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HV197_RS09545	COG2181	nitrate reductase activity
HV197_RS09555	COG1522	sequence-specific DNA binding
HV197_RS09585	COG0788	formyltetrahydrofolate deformylase activity
HV197_RS09595	COG1752	Esterase of the alpha-beta hydrolase superfamily
HV197_RS09600	COG0745	RESPONSE REGULATOR receiver
HV197_RS09605	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HV197_RS09610	COG2916	Histone family protein nucleoid-structuring protein H-NS
HV197_RS09620	COG1435	thymidine kinase activity
HV197_RS09625	COG1012	belongs to the aldehyde dehydrogenase family
HV197_RS09625	COG1454	alcohol dehydrogenase
HV197_RS09635	COG2095	MarC family integral membrane protein
HV197_RS09640	COG4166	transmembrane transport
HV197_RS09645	COG0601	transmembrane transport
HV197_RS09650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV197_RS09655	COG0444	Belongs to the ABC transporter superfamily
HV197_RS09665	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV197_RS09685	COG2353	YceI-like domain
HV197_RS09695	COG2350	Protein conserved in bacteria
HV197_RS09705	COG3001	Fructosamine kinase
HV197_RS09715	COG1105	Belongs to the carbohydrate kinase PfkB family
HV197_RS09720	COG3137	Salt-induced outer membrane protein
HV197_RS09760	COG0072	phenylalanine-tRNA ligase activity
HV197_RS09760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HV197_RS09780	COG0583	DNA-binding transcription factor activity
HV197_RS09800	COG0386	Belongs to the glutathione peroxidase family
HV197_RS09810	COG0791	NLP P60 protein
HV197_RS09820	COG4256	Hemin uptake protein
HV197_RS09825	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV197_RS09840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HV197_RS09840	COG0574	Belongs to the PEP-utilizing enzyme family
HV197_RS09850	COG0628	permease
HV197_RS09855	COG0277	FAD linked oxidase domain protein
HV197_RS09855	COG0247	lactate metabolic process
HV197_RS09860	COG2050	protein possibly involved in aromatic compounds catabolism
HV197_RS09865	COG2261	transglycosylase associated protein
HV197_RS09890	COG1120	ATPase activity
HV197_RS09895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV197_RS09905	COG0583	DNA-binding transcription factor activity
HV197_RS09930	COG1304	FMN binding
HV197_RS09935	COG1309	transcriptional regulator
HV197_RS09955	COG0316	Belongs to the HesB IscA family
HV197_RS09960	COG0719	Fe-S assembly protein
HV197_RS09965	COG0396	ATPase activity
HV197_RS09970	COG0719	Fe-S assembly protein
HV197_RS09985	COG1376	ErfK ybiS ycfS ynhG family protein
HV197_RS10015	COG1309	transcriptional regulator
HV197_RS10025	COG2271	Major facilitator Superfamily
HV197_RS10030	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HV197_RS10055	COG1414	Transcriptional regulator
HV197_RS10090	COG2814	Major facilitator Superfamily
HV197_RS10110	COG0583	DNA-binding transcription factor activity
HV197_RS10115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV197_RS10135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV197_RS10140	COG1116	anion transmembrane transporter activity
HV197_RS10145	COG4774	siderophore transport
HV197_RS10150	COG1120	ATPase activity
HV197_RS10155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV197_RS10160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV197_RS10180	COG0765	amino acid transport
HV197_RS10185	COG1126	abc transporter atp-binding protein
HV197_RS10225	COG3383	formate dehydrogenase (NAD+) activity
HV197_RS10230	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HV197_RS10240	COG1175	transmembrane transport
HV197_RS10270	COG4133	protoheme IX ABC transporter activity
HV197_RS10275	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HV197_RS10280	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HV197_RS10295	COG1138	Cytochrome C-type biogenesis protein
HV197_RS10300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HV197_RS10305	COG4235	cytochrome complex assembly
HV197_RS10305	COG3088	subunit of a heme lyase
HV197_RS10325	COG3850	Histidine kinase
HV197_RS10325	COG5002	protein histidine kinase activity
HV197_RS10330	COG0745	RESPONSE REGULATOR receiver
HV197_RS10345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV197_RS10375	COG1028	Short-chain dehydrogenase reductase Sdr
HV197_RS10380	COG2610	gluconate transmembrane transporter activity
HV197_RS10385	COG1250	3-hydroxyacyl-CoA dehydrogenase
HV197_RS10395	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HV197_RS10405	COG0583	DNA-binding transcription factor activity
HV197_RS10425	COG0277	FAD linked oxidase domain protein
HV197_RS10430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV197_RS10455	COG0402	S-adenosylhomocysteine deaminase activity
HV197_RS10515	COG0444	Belongs to the ABC transporter superfamily
HV197_RS10540	COG0346	lactoylglutathione lyase activity
HV197_RS10545	COG1349	DNA-binding transcription factor activity
HV197_RS10580	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HV197_RS10600	COG0300	oxidoreductase activity
HV197_RS10645	COG0307	riboflavin synthase, alpha
HV197_RS10650	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HV197_RS10655	COG2814	Major facilitator Superfamily
HV197_RS10660	COG0583	DNA-binding transcription factor activity
HV197_RS10675	COG2814	Major facilitator Superfamily
HV197_RS10690	COG0791	NLP P60 protein
HV197_RS10695	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HV197_RS10705	COG0346	lactoylglutathione lyase activity
HV197_RS10710	COG1902	pentaerythritol trinitrate reductase activity
HV197_RS10715	COG1309	transcriptional regulator
HV197_RS10720	COG3313	Fe-S protein
HV197_RS10725	COG4989	oxidoreductase activity
HV197_RS10730	COG2032	superoxide dismutase activity
HV197_RS10735	COG1289	transmembrane transporter activity
HV197_RS10740	COG1566	PFAM secretion protein HlyD family protein
HV197_RS10755	COG3706	GGDEF domain
HV197_RS10770	COG3895	Periplasmic Protein
HV197_RS10785	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HV197_RS10790	COG0625	glutathione transferase activity
HV197_RS10800	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HV197_RS10810	COG4659	FMN binding
HV197_RS10845	COG2723	6-phospho-beta-galactosidase activity
HV197_RS10855	COG0673	inositol 2-dehydrogenase activity
HV197_RS10865	COG2814	Major facilitator Superfamily
HV197_RS10885	COG3038	cytochrome b561
HV197_RS10905	COG0583	DNA-binding transcription factor activity
HV197_RS10910	COG3485	protocatechuate 3,4-dioxygenase
HV197_RS10915	COG3485	protocatechuate 3,4-dioxygenase
HV197_RS10920	COG5383	Protein conserved in bacteria
HV197_RS10925	COG2272	Belongs to the type-B carboxylesterase lipase family
HV197_RS10940	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV197_RS10945	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV197_RS10950	COG1275	C4-dicarboxylate transporter malic acid transport protein
HV197_RS10955	COG0500	methyltransferase
HV197_RS10970	COG3708	Transcriptional regulator
HV197_RS10970	COG2207	Transcriptional regulator
HV197_RS10975	COG3135	benzoate transporter
HV197_RS10980	COG1396	sequence-specific DNA binding
HV197_RS10990	COG0826	peptidase U32
HV197_RS11010	COG1294	oxidase, subunit
HV197_RS11015	COG1271	oxidase subunit
HV197_RS11020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV197_RS11025	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HV197_RS11030	COG3842	ATPase activity
HV197_RS11035	COG1176	ABC-type spermidine putrescine transport system, permease component I
HV197_RS11040	COG1177	transmembrane transport
HV197_RS11045	COG1012	belongs to the aldehyde dehydrogenase family
HV197_RS11080	COG1012	belongs to the aldehyde dehydrogenase family
HV197_RS11085	COG0747	negative chemotaxis
HV197_RS11095	COG3238	Protein conserved in bacteria
HV197_RS11100	COG1247	-acetyltransferase
HV197_RS11110	COG2130	NADP-dependent
HV197_RS11125	COG3691	Protein conserved in bacteria
HV197_RS11135	COG4772	TonB-dependent receptor
HV197_RS11160	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HV197_RS11165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV197_RS11170	COG1473	amidohydrolase
HV197_RS11175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV197_RS11190	COG0765	amino acid transport
HV197_RS11195	COG1126	abc transporter atp-binding protein
HV197_RS11215	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HV197_RS11220	COG3842	ATPase activity
HV197_RS11225	COG1840	ABC-type Fe3 transport system, periplasmic component
HV197_RS11230	COG1178	ABC-type Fe3 transport system permease component
HV197_RS11235	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HV197_RS11240	COG2181	nitrate reductase activity
HV197_RS11245	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HV197_RS11250	COG1140	nitrate reductase beta subunit
HV197_RS11255	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HV197_RS11275	COG1414	Transcriptional regulator
HV197_RS11280	COG4948	Mandelate Racemase Muconate Lactonizing
HV197_RS11285	COG4829	muconolactone delta-isomerase
HV197_RS11290	COG3485	protocatechuate 3,4-dioxygenase
HV197_RS11300	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HV197_RS11325	COG0437	4 iron, 4 sulfur cluster binding
HV197_RS11330	COG2864	formate dehydrogenase
HV197_RS11345	COG2326	polyphosphate kinase activity
HV197_RS11355	COG2814	Major facilitator Superfamily
HV197_RS11365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV197_RS11385	COG0747	negative chemotaxis
HV197_RS11390	COG1064	alcohol dehydrogenase
HV197_RS11405	COG0488	(ABC) transporter
HV197_RS11450	COG1028	Short-chain dehydrogenase reductase Sdr
HV197_RS11455	COG3729	General stress protein
HV197_RS11465	COG3685	Protein conserved in bacteria
HV197_RS11475	COG0366	Alpha amylase catalytic
HV197_RS11485	COG2323	membrane
HV197_RS11495	COG3111	PFAM Bacterial OB fold (BOF) protein
HV197_RS11505	COG1764	response to oxidative stress
HV197_RS11530	COG3781	membrane
HV197_RS11535	COG0243	molybdopterin cofactor binding
HV197_RS11540	COG0583	DNA-binding transcription factor activity
HV197_RS11545	COG2814	Major facilitator Superfamily
HV197_RS11550	COG1285	pathogenesis
HV197_RS11565	COG0583	DNA-binding transcription factor activity
HV197_RS11585	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HV197_RS11585	COG0519	Catalyzes the synthesis of GMP from XMP
HV197_RS11625	COG0596	Alpha beta hydrolase
HV197_RS11630	COG0745	RESPONSE REGULATOR receiver
HV197_RS11635	COG2205	protein histidine kinase activity
HV197_RS11650	COG0076	glutamate decarboxylase activity
HV197_RS11655	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV197_RS11660	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HV197_RS11665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV197_RS11670	COG1116	anion transmembrane transporter activity
HV197_RS11675	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HV197_RS11690	COG0673	inositol 2-dehydrogenase activity
HV197_RS11700	COG1609	Transcriptional regulator
HV197_RS11705	COG3706	GGDEF domain
HV197_RS11710	COG0402	S-adenosylhomocysteine deaminase activity
HV197_RS11715	COG1953	Uracil, thiamine, allantoin
HV197_RS11750	COG1715	Restriction endonuclease
HV197_RS11765	COG2207	Transcriptional regulator
HV197_RS11780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV197_RS11860	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HV197_RS11870	COG2070	2-Nitropropane dioxygenase
HV197_RS11875	COG0583	DNA-binding transcription factor activity
HV197_RS11885	COG1902	pentaerythritol trinitrate reductase activity
HV197_RS11890	COG4529	Protein conserved in bacteria
HV197_RS11895	COG0477	Major facilitator Superfamily
HV197_RS11940	COG2223	nitrite transmembrane transporter activity
HV197_RS11950	COG1609	Transcriptional regulator
HV197_RS11955	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV197_RS11965	COG3037	sugar-specific permease SgaT UlaA
HV197_RS11970	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HV197_RS11980	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV197_RS11985	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV197_RS11985	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HV197_RS11985	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV197_RS12000	COG0583	DNA-binding transcription factor activity
HV197_RS12005	COG0583	DNA-binding transcription factor activity
HV197_RS12010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV197_RS12020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HV197_RS12035	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV197_RS12045	COG1609	Transcriptional regulator
HV197_RS12075	COG1652	LysM domain
HV197_RS12100	COG0456	acetyltransferase
HV197_RS12100	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HV197_RS12110	COG0667	Aldo Keto reductase
HV197_RS12115	COG0667	Aldo Keto reductase
HV197_RS12120	COG3386	PFAM SMP-30 Gluconolaconase
HV197_RS12125	COG0667	Aldo Keto reductase
HV197_RS12140	COG2801	Transposase and inactivated derivatives
HV197_RS12160	COG1349	DNA-binding transcription factor activity
HV197_RS12165	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HV197_RS12170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV197_RS12175	COG0738	Major facilitator superfamily
HV197_RS12200	COG0183	Belongs to the thiolase family
HV197_RS12220	COG1929	Belongs to the glycerate kinase type-1 family
HV197_RS12225	COG3835	regulator
HV197_RS12245	COG2186	Transcriptional regulator
HV197_RS12250	COG1263	PTS System
HV197_RS12250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV197_RS12260	COG2814	Major facilitator Superfamily
HV197_RS12265	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV197_RS12265	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV197_RS12280	COG2819	hydrolase of the alpha beta superfamily
HV197_RS12285	COG3300	MHYT domain
HV197_RS12285	COG5001	Diguanylate cyclase
HV197_RS12320	COG3188	usher protein
HV197_RS12335	COG3550	peptidyl-serine autophosphorylation
HV197_RS12340	COG1396	sequence-specific DNA binding
HV197_RS12345	COG2351	hydroxyisourate hydrolase activity
HV197_RS12350	COG3195	allantoin biosynthetic process
HV197_RS12350	COG3648	Uricase
HV197_RS12355	COG2233	PERMEase
HV197_RS12385	COG2207	Transcriptional regulator
HV197_RS12400	COG4628	conserved protein (DUF2132)
HV197_RS12420	COG2011	ABC-type metal ion transport system permease component
HV197_RS12425	COG2070	2-Nitropropane dioxygenase
HV197_RS12435	COG0477	Major facilitator Superfamily
HV197_RS12485	COG2199	diguanylate cyclase activity
HV197_RS12500	COG1012	belongs to the aldehyde dehydrogenase family
HV197_RS12505	COG0583	DNA-binding transcription factor activity
HV197_RS12515	COG0039	L-malate dehydrogenase activity
HV197_RS12520	COG1349	DNA-binding transcription factor activity
HV197_RS12525	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HV197_RS12530	COG3395	kinase activity
HV197_RS12540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HV197_RS12545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV197_RS12550	COG2271	Major facilitator Superfamily
HV197_RS12580	COG4977	sequence-specific DNA binding
HV197_RS12590	COG0697	spore germination
HV197_RS12595	COG2814	Major facilitator Superfamily
HV197_RS12610	COG1129	ABC transporter
HV197_RS12630	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HV197_RS12665	COG2223	nitrite transmembrane transporter activity
HV197_RS12670	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HV197_RS12685	COG1349	DNA-binding transcription factor activity
HV197_RS12695	COG3395	kinase activity
HV197_RS12700	COG0235	Class ii aldolase
HV197_RS12705	COG3622	Belongs to the hyi family
HV197_RS12710	COG2610	gluconate transmembrane transporter activity
HV197_RS12715	COG2207	Transcriptional regulator
HV197_RS12715	COG3708	Transcriptional regulator
HV197_RS12730	COG2200	EAL domain
HV197_RS12735	COG1546	Belongs to the CinA family
HV197_RS12740	COG0071	Belongs to the small heat shock protein (HSP20) family
HV197_RS12770	COG2135	peptidase activity
HV197_RS12775	COG2207	Transcriptional regulator
HV197_RS12785	COG0339	signal peptide processing
HV197_RS12790	COG4221	oxidoreductase activity
HV197_RS12795	COG1802	Transcriptional regulator
HV197_RS12800	COG0589	response to stress
HV197_RS12805	COG0246	Mannitol dehydrogenase
HV197_RS12810	COG2271	Major facilitator Superfamily
HV197_RS12825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV197_RS12840	COG0243	molybdopterin cofactor binding
HV197_RS12845	COG0437	4 iron, 4 sulfur cluster binding
HV197_RS12850	COG3302	dmso reductase anchor subunit
HV197_RS12865	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HV197_RS12870	COG1940	carbohydrate kinase activity
HV197_RS12875	COG0583	DNA-binding transcription factor activity
HV197_RS12880	COG2814	Major facilitator Superfamily
HV197_RS12885	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HV197_RS12895	COG3591	Belongs to the peptidase S1B family
HV197_RS12915	COG0628	permease
HV197_RS12945	COG0679	Auxin Efflux Carrier
HV197_RS12955	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HV197_RS12980	COG3290	protein histidine kinase activity
HV197_RS12985	COG4565	transcriptional regulatory protein
HV197_RS13005	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV197_RS13005	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV197_RS13015	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV197_RS13020	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HV197_RS13030	COG0183	Belongs to the thiolase family
HV197_RS13035	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HV197_RS13045	COG1414	Transcriptional regulator
HV197_RS13050	COG2840	Smr protein MutS2
HV197_RS13055	COG0583	DNA-binding transcription factor activity
HV197_RS13065	COG1473	amidohydrolase
HV197_RS13070	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HV197_RS13085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV197_RS13100	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HV197_RS13105	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HV197_RS13120	COG0531	amino acid
HV197_RS13130	COG3136	membrane protein required for alginate biosynthesis
HV197_RS13135	COG0745	RESPONSE REGULATOR receiver
HV197_RS13145	COG2205	protein histidine kinase activity
HV197_RS13155	COG0114	fumarate hydratase activity
HV197_RS13160	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV197_RS13160	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV197_RS13165	COG1482	cell wall glycoprotein biosynthetic process
HV197_RS13170	COG5339	Protein conserved in bacteria
HV197_RS13175	COG1609	Transcriptional regulator
HV197_RS13180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV197_RS13180	COG1263	PTS System
HV197_RS13185	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HV197_RS13210	COG2391	methyltransferase activity
HV197_RS13215	COG0425	Belongs to the sulfur carrier protein TusA family
HV197_RS13220	COG5562	phage envelope protein
HV197_RS13225	COG0401	homolog of Blt101
HV197_RS13230	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HV197_RS13235	COG1012	belongs to the aldehyde dehydrogenase family
HV197_RS13245	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HV197_RS13250	COG0477	Major facilitator Superfamily
HV197_RS13255	COG1113	amino acid transport
HV197_RS13260	COG2988	succinylglutamate desuccinylase activity
HV197_RS13265	COG3724	N-succinylarginine dihydrolase activity
HV197_RS13270	COG1012	belongs to the aldehyde dehydrogenase family
HV197_RS13275	COG3138	arginine N-succinyltransferase
HV197_RS13280	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HV197_RS13290	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HV197_RS13295	COG0667	Aldo Keto reductase
HV197_RS13300	COG0583	DNA-binding transcription factor activity
HV197_RS13325	COG4122	O-methyltransferase activity
HV197_RS13330	COG1643	Atp-dependent helicase
HV197_RS13345	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV197_RS13350	COG3327	negative regulation of DNA-templated transcription, initiation
HV197_RS13355	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HV197_RS13360	COG0183	Belongs to the thiolase family
HV197_RS13365	COG2050	protein possibly involved in aromatic compounds catabolism
HV197_RS13370	COG1250	3-hydroxyacyl-CoA dehydrogenase
HV197_RS13375	COG1024	Enoyl-CoA hydratase
HV197_RS13380	COG1024	Enoyl-CoA hydratase
HV197_RS13385	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV197_RS13390	COG2151	metal-sulfur cluster biosynthetic enzyme
HV197_RS13395	COG3396	Phenylacetate-CoA oxygenase
HV197_RS13400	COG3460	Phenylacetate-CoA oxygenase
HV197_RS13405	COG3396	Phenylacetate-CoA oxygenase
HV197_RS13410	COG2030	dehydratase
HV197_RS13410	COG1012	belongs to the aldehyde dehydrogenase family
HV197_RS13430	COG1012	belongs to the aldehyde dehydrogenase family
HV197_RS13435	COG2207	Transcriptional regulator
HV197_RS13440	COG3784	Protein of unknown function (DUF1318)
HV197_RS13450	COG2911	Protein conserved in bacteria
HV197_RS13455	COG0586	Pfam SNARE associated Golgi protein
HV197_RS13460	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HV197_RS13465	COG3187	Heat shock protein
HV197_RS13470	COG3042	response to heat
HV197_RS13475	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HV197_RS13475	COG0674	pyruvate-flavodoxin oxidoreductase activity
HV197_RS13475	COG1013	pyruvate-flavodoxin oxidoreductase activity
HV197_RS13475	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV197_RS13480	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV197_RS13490	COG0589	response to stress
HV197_RS13500	COG0513	Belongs to the DEAD box helicase family
HV197_RS13510	COG1349	DNA-binding transcription factor activity
HV197_RS13515	COG0673	inositol 2-dehydrogenase activity
HV197_RS13530	COG1113	amino acid transport
HV197_RS13535	COG1522	sequence-specific DNA binding
HV197_RS13545	COG1448	Aminotransferase
HV197_RS13550	COG2011	ABC-type metal ion transport system permease component
HV197_RS13565	COG0436	Aminotransferase
HV197_RS13570	COG0604	alcohol dehydrogenase
HV197_RS13600	COG0583	DNA-binding transcription factor activity
HV197_RS13620	COG1028	Short-chain dehydrogenase reductase Sdr
HV197_RS13625	COG1309	transcriptional regulator
HV197_RS13630	COG1028	Short-chain dehydrogenase reductase Sdr
HV197_RS13705	COG2885	chlorophyll binding
HV197_RS13845	COG0740	serine-type endopeptidase activity
HV197_RS13850	COG4695	Portal protein
HV197_RS13855	COG1802	Transcriptional regulator
HV197_RS13855	COG4626	Terminase
HV197_RS13930	COG4626	Terminase
HV197_RS13930	COG1802	Transcriptional regulator
HV197_RS14000	COG0582	viral genome integration into host DNA
HV197_RS14005	COG0693	protein deglycase activity
HV197_RS14010	COG1078	dGTPase activity
HV197_RS14015	COG1028	Short-chain dehydrogenase reductase Sdr
HV197_RS14020	COG0583	DNA-binding transcription factor activity
HV197_RS14035	COG0656	L-ascorbic acid biosynthetic process
HV197_RS14065	COG4166	transmembrane transport
HV197_RS14075	COG2866	Carboxypeptidase
HV197_RS14080	COG4948	Mandelate Racemase Muconate Lactonizing
HV197_RS14085	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HV197_RS14090	COG3180	Ammonia monooxygenase
HV197_RS14100	COG1486	melibiose metabolic process
HV197_RS14105	COG0583	DNA-binding transcription factor activity
HV197_RS14115	COG3106	COG3106 Predicted ATPase
HV197_RS14125	COG1983	PspC domain protein
HV197_RS14135	COG1842	Phage shock protein A
HV197_RS14140	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HV197_RS14150	COG1473	amidohydrolase
HV197_RS14165	COG0702	epimerase
HV197_RS14190	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HV197_RS14195	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HV197_RS14310	COG4695	Portal protein
HV197_RS14315	COG4626	Terminase
HV197_RS14315	COG1802	Transcriptional regulator
HV197_RS14380	COG3436	PFAM IS66 Orf2 family protein
HV197_RS14385	COG4372	Transposase
HV197_RS14390	COG3477	response to acidic pH
HV197_RS14440	COG1484	DNA-dependent DNA replication
HV197_RS14490	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV197_RS14510	COG4171	peptide transport system, permease
HV197_RS14525	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HV197_RS14535	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HV197_RS14540	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV197_RS14540	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV197_RS14555	COG1349	DNA-binding transcription factor activity
HV197_RS14565	COG0023	Translation Initiation Factor
HV197_RS14575	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HV197_RS14580	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HV197_RS14585	COG0671	phosphoesterase, PA-phosphatase related
HV197_RS14595	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HV197_RS14620	COG0616	signal peptide processing
HV197_RS14630	COG1028	Short-chain dehydrogenase reductase Sdr
HV197_RS14635	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HV197_RS14645	COG0583	DNA-binding transcription factor activity
HV197_RS14655	COG0009	L-threonylcarbamoyladenylate synthase
HV197_RS14665	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HV197_RS14670	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HV197_RS14670	COG0512	Glutamine amidotransferase of anthranilate synthase
HV197_RS14675	COG0134	indole-3-glycerol-phosphate synthase activity
HV197_RS14675	COG0135	phosphoribosylanthranilate isomerase activity
HV197_RS14730	COG4774	siderophore transport
HV197_RS14740	COG3047	cAMP biosynthetic process
HV197_RS14745	COG0727	PFAM Uncharacterised protein family (UPF0153)
HV197_RS14775	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV197_RS14780	COG1028	Short-chain dehydrogenase reductase Sdr
HV197_RS14785	COG1988	membrane-bound metal-dependent
HV197_RS14800	COG0753	catalase activity
HV197_RS14810	COG1486	melibiose metabolic process
HV197_RS14815	COG2169	Transcriptional regulator
HV197_RS14815	COG1917	Cupin 2, conserved barrel domain protein
HV197_RS14820	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV197_RS14825	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV197_RS14835	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV197_RS14840	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV197_RS14850	COG0322	excinuclease ABC activity
HV197_RS14855	COG3678	ATP-independent chaperone mediated protein folding
HV197_RS14865	COG3724	N-succinylarginine dihydrolase activity
HV197_RS14875	COG3138	arginine N-succinyltransferase
HV197_RS14885	COG0708	Exodeoxyribonuclease III
HV197_RS14890	COG0398	Pfam SNARE associated Golgi protein
HV197_RS14895	COG0398	Pfam SNARE associated Golgi protein
HV197_RS14900	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV197_RS14905	COG4134	Bacterial extracellular solute-binding protein
HV197_RS14910	COG4135	transport system, permease component
HV197_RS14915	COG4136	ATPase activity
HV197_RS14920	COG2897	thiosulfate sulfurtransferase activity
HV197_RS14925	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HV197_RS14930	COG0494	nUDIX hydrolase
HV197_RS14935	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HV197_RS14940	COG1028	Short-chain dehydrogenase reductase Sdr
HV197_RS14940	COG0604	alcohol dehydrogenase
HV197_RS14940	COG3321	synthase
HV197_RS14945	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HV197_RS14950	COG0709	Synthesizes selenophosphate from selenide and ATP
HV197_RS14960	COG0778	Nitroreductase
HV197_RS14965	COG0616	signal peptide processing
HV197_RS14970	COG0252	asparaginase activity
HV197_RS14975	COG1335	isochorismatase
HV197_RS14990	COG3139	Protein of unknown function (DUF1315)
HV197_RS15010	COG0656	L-ascorbic acid biosynthetic process
HV197_RS15015	COG3713	MltA-interacting MipA family protein
HV197_RS15020	COG2766	serine protein kinase
HV197_RS15060	COG1028	Short-chain dehydrogenase reductase Sdr
HV197_RS15065	COG0583	DNA-binding transcription factor activity
HV197_RS15070	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HV197_RS15075	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HV197_RS15085	COG0859	PFAM glycosyl transferase family 9
HV197_RS15090	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV197_RS15100	COG2207	Transcriptional regulator
HV197_RS15105	COG2807	transmembrane transport
HV197_RS15110	COG0504	CTP synthase activity
HV197_RS15115	COG1683	Conserved Protein
HV197_RS15120	COG3189	MarR family transcriptional regulator
HV197_RS15125	COG3042	response to heat
HV197_RS15170	COG1078	dGTPase activity
HV197_RS15260	COG4695	Portal protein
HV197_RS15285	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HV197_RS15325	COG4974	Belongs to the 'phage' integrase family
HV197_RS15330	COG2203	Gaf domain
HV197_RS15330	COG2199	diguanylate cyclase activity
HV197_RS15350	COG3182	Iron-regulated membrane protein
HV197_RS15360	COG1560	Kdo2-lipid A biosynthetic process
HV197_RS15370	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HV197_RS15375	COG3706	GGDEF domain
HV197_RS15380	COG0583	DNA-binding transcription factor activity
HV197_RS15385	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HV197_RS15415	COG1294	oxidase, subunit
HV197_RS15420	COG1271	oxidase subunit
HV197_RS15425	COG3546	catalase activity
HV197_RS15430	COG3685	Protein conserved in bacteria
HV197_RS15435	COG3685	Protein conserved in bacteria
HV197_RS15440	COG3729	General stress protein
HV197_RS15450	COG1063	alcohol dehydrogenase
HV197_RS15455	COG3813	Protein conserved in bacteria
HV197_RS15475	COG0640	Transcriptional regulator
HV197_RS15480	COG0538	isocitrate dehydrogenase activity
HV197_RS15485	COG1187	pseudouridine synthase activity
HV197_RS15505	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HV197_RS15525	COG2205	protein histidine kinase activity
HV197_RS15530	COG2850	peptidyl-arginine hydroxylation
HV197_RS15550	COG1177	transmembrane transport
HV197_RS15565	COG0318	PFAM AMP-dependent synthetase and ligase
HV197_RS15570	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV197_RS15575	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HV197_RS15580	COG0698	ribose 5-phosphate isomerase
HV197_RS15595	COG3395	kinase activity
HV197_RS15610	COG2390	Transcriptional regulator
HV197_RS15620	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HV197_RS15630	COG4591	ABC-type transport system involved in lipoprotein release permease component
HV197_RS15640	COG4591	ABC-type transport system involved in lipoprotein release permease component
HV197_RS15650	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HV197_RS15655	COG1376	ErfK ybiS ycfS ynhG family protein
HV197_RS15655	COG1388	LysM domain
HV197_RS15670	COG1309	transcriptional regulator
HV197_RS15685	COG3134	Outer membrane lipoprotein
HV197_RS15690	COG1252	NADH dehydrogenase
HV197_RS15715	COG5633	Lipoprotein
HV197_RS15720	COG0537	adenosine 5'-monophosphoramidase activity
HV197_RS15730	COG0084	hydrolase, TatD family'
HV197_RS15735	COG0470	DNA polymerase III
HV197_RS15745	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HV197_RS15750	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HV197_RS15755	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV197_RS15770	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HV197_RS15790	COG1399	metal-binding, possibly nucleic acid-binding protein
HV197_RS15810	COG1530	ribonuclease E activity
HV197_RS15815	COG0583	DNA-binding transcription factor activity
HV197_RS15820	COG2814	Major facilitator Superfamily
HV197_RS15840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV197_RS15885	COG1560	Kdo2-lipid A biosynthetic process
HV197_RS15900	COG5645	(Lipo)protein
HV197_RS15935	COG3381	protein complex oligomerization
HV197_RS15955	COG0583	DNA-binding transcription factor activity
HV197_RS15965	COG1335	isochorismatase
HV197_RS16035	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HV197_RS16040	COG1702	phosphate starvation-inducible protein PhoH
HV197_RS16060	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV197_RS16070	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HV197_RS16085	COG1309	transcriptional regulator
HV197_RS16120	COG2233	PERMEase
HV197_RS16130	COG3729	General stress protein
HV197_RS16160	COG1028	Short-chain dehydrogenase reductase Sdr
HV197_RS16175	COG0531	amino acid
HV197_RS16180	COG0174	glutamine synthetase
HV197_RS16185	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HV197_RS16190	COG1396	sequence-specific DNA binding
HV197_RS16190	COG1917	Cupin 2, conserved barrel domain protein
HV197_RS16195	COG1012	belongs to the aldehyde dehydrogenase family
HV197_RS16200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HV197_RS16205	COG0583	DNA-binding transcription factor activity
HV197_RS16210	COG0473	3-isopropylmalate dehydrogenase activity
HV197_RS16215	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HV197_RS16220	COG4638	Rieske (2fe-2S)
HV197_RS16225	COG1012	belongs to the aldehyde dehydrogenase family
HV197_RS16230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV197_RS16255	COG0670	Belongs to the BI1 family
HV197_RS16270	COG2207	Transcriptional regulator
HV197_RS16275	COG1881	PFAM PEBP family protein
HV197_RS16300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV197_RS16305	COG2274	protein secretion by the type I secretion system
HV197_RS16315	COG1832	CoA-binding protein
HV197_RS16325	COG0210	DNA helicase
HV197_RS16330	COG3304	Inner membrane component domain
HV197_RS16335	COG1289	transmembrane transporter activity
HV197_RS16340	COG3070	regulator of competence-specific genes
HV197_RS16360	COG1067	ATP-dependent peptidase activity
HV197_RS16370	COG3130	regulation of translation
HV197_RS16375	COG3009	Protein conserved in bacteria
HV197_RS16380	COG3008	intermembrane lipid transfer
HV197_RS16380	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HV197_RS16385	COG2995	paraquat-inducible protein a
HV197_RS16390	COG0488	(ABC) transporter
HV197_RS16400	COG3217	Mosc domain protein beta barrel domain protein
HV197_RS16400	COG0633	Ferredoxin
HV197_RS16415	COG0431	NADPH-dependent FMN reductase
HV197_RS16420	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HV197_RS16425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV197_RS16430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV197_RS16440	COG0308	aminopeptidase N
HV197_RS16450	COG1473	amidohydrolase
HV197_RS16460	COG0814	amino acid
HV197_RS16480	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV197_RS16485	COG1448	Aminotransferase
HV197_RS16490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV197_RS16495	COG3108	Peptidase M15
HV197_RS16500	COG2989	Protein conserved in bacteria
HV197_RS16510	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HV197_RS16520	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HV197_RS16525	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HV197_RS16530	COG3173	Aminoglycoside phosphotransferase
HV197_RS16545	COG3214	Protein conserved in bacteria
HV197_RS16560	COG2333	competence protein COMEC
HV197_RS16560	COG0658	competence protein
HV197_RS16570	COG0539	negative regulation of cytoplasmic translation
HV197_RS16590	COG2323	membrane
HV197_RS16595	COG1944	ATP diphosphatase activity
HV197_RS16600	COG2116	formate transmembrane transporter activity
HV197_RS16605	COG1882	Formate acetyltransferase
HV197_RS16610	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV197_RS16615	COG0477	Major facilitator Superfamily
HV197_RS16620	COG3302	dmso reductase anchor subunit
HV197_RS16625	COG0437	4 iron, 4 sulfur cluster binding
HV197_RS16630	COG0243	molybdopterin cofactor binding
HV197_RS16640	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HV197_RS16650	COG1178	ABC-type Fe3 transport system permease component
HV197_RS16650	COG1674	ftsk spoiiie
HV197_RS16660	COG0492	ferredoxin-NADP+ reductase activity
HV197_RS16665	COG4988	ABC transporter
HV197_RS16670	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HV197_RS16685	COG0542	response to heat
HV197_RS16695	COG1278	Cold shock
HV197_RS16705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV197_RS16710	COG3593	DNA synthesis involved in DNA repair
HV197_RS16720	COG2431	L-lysine efflux transmembrane transporter activity
HV197_RS16730	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV197_RS16740	COG0028	Belongs to the TPP enzyme family
HV197_RS16745	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HV197_RS16750	COG0702	epimerase
HV197_RS16755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV197_RS16760	COG3023	N-Acetylmuramoyl-L-alanine amidase
HV197_RS16765	COG2203	Gaf domain
HV197_RS16765	COG3706	GGDEF domain
HV197_RS16765	COG4251	negative regulation of phosphorylation
HV197_RS16765	COG5001	Diguanylate cyclase
HV197_RS16775	COG1126	abc transporter atp-binding protein
HV197_RS16780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV197_RS16785	COG4215	(ABC) transporter
HV197_RS16790	COG4160	amino acid transport
HV197_RS16795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV197_RS16800	COG5002	protein histidine kinase activity
HV197_RS16805	COG0745	RESPONSE REGULATOR receiver
HV197_RS16820	COG1177	transmembrane transport
HV197_RS16825	COG1176	ABC-type spermidine putrescine transport system, permease component I
HV197_RS16830	COG3842	ATPase activity
HV197_RS16835	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HV197_RS16850	COG0778	Nitroreductase
HV197_RS16875	COG3226	Transcriptional regulator
HV197_RS16880	COG0738	Major facilitator superfamily
HV197_RS16885	COG0561	phosphatase activity
HV197_RS16890	COG2814	Major facilitator Superfamily
HV197_RS16895	COG0671	phosphoesterase, PA-phosphatase related
HV197_RS16900	COG1349	DNA-binding transcription factor activity
HV197_RS16905	COG1686	Belongs to the peptidase S11 family
HV197_RS16915	COG0625	glutathione transferase activity
HV197_RS16920	COG2133	pyrroloquinoline quinone binding
HV197_RS16930	COG2223	nitrite transmembrane transporter activity
HV197_RS16950	COG0747	negative chemotaxis
HV197_RS16965	COG0303	'Molybdopterin
HV197_RS16970	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HV197_RS16975	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV197_RS16980	COG1882	Formate acetyltransferase
HV197_RS16985	COG0561	phosphatase activity
HV197_RS16995	COG1609	Transcriptional regulator
HV197_RS17000	COG2271	Major facilitator Superfamily
HV197_RS17010	COG0488	(ABC) transporter
HV197_RS17015	COG2365	Tyrosine phosphatase family
HV197_RS17020	COG1376	ErfK ybiS ycfS ynhG family protein
HV197_RS17025	COG2188	Transcriptional regulator
HV197_RS17030	COG2723	6-phospho-beta-galactosidase activity
HV197_RS17035	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HV197_RS17050	COG2194	sulfuric ester hydrolase activity
HV197_RS17055	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HV197_RS17070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV197_RS17075	COG0765	amino acid transport
HV197_RS17080	COG1126	abc transporter atp-binding protein
HV197_RS17085	COG0668	transmembrane transport
HV197_RS17095	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HV197_RS17105	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HV197_RS17115	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HV197_RS17120	COG1199	ATP-dependent helicase activity
HV197_RS17125	COG0513	Belongs to the DEAD box helicase family
HV197_RS17130	COG3958	Transketolase
HV197_RS17135	COG3959	Transketolase, thiamine diphosphate binding domain
HV197_RS17140	COG1028	Short-chain dehydrogenase reductase Sdr
HV197_RS17145	COG2271	Major facilitator Superfamily
HV197_RS17155	COG0583	DNA-binding transcription factor activity
HV197_RS17160	COG1309	transcriptional regulator
HV197_RS17165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV197_RS17170	COG1131	(ABC) transporter
HV197_RS17175	COG0842	Transport permease protein
HV197_RS17180	COG0842	Transport permease protein
HV197_RS17190	COG3568	Endonuclease Exonuclease Phosphatase
HV197_RS17195	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV197_RS17200	COG0392	lysyltransferase activity
HV197_RS17205	COG0670	Belongs to the BI1 family
HV197_RS17210	COG0314	molybdopterin synthase activity
HV197_RS17215	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HV197_RS17225	COG0521	Mo-molybdopterin cofactor biosynthetic process
HV197_RS17245	COG0745	RESPONSE REGULATOR receiver
HV197_RS17250	COG0642	Histidine kinase
HV197_RS17275	COG2226	methyltransferase
HV197_RS17290	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HV197_RS17295	COG1881	PFAM PEBP family protein
HV197_RS17335	COG4677	pectinesterase activity
HV197_RS17345	COG0589	response to stress
HV197_RS17350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV197_RS17385	COG0789	Transcriptional regulator
HV197_RS17390	COG2200	EAL domain
HV197_RS17415	COG0561	phosphatase activity
HV197_RS17425	COG4149	molybdate abc transporter
HV197_RS17430	COG0725	ABC transporter, periplasmic molybdate-binding protein
HV197_RS17440	COG2005	Transcriptional regulator
HV197_RS17440	COG3585	molybdate ion transport
HV197_RS17445	COG1119	ATPase activity
HV197_RS17455	COG1085	galactose-1-phosphate uridylyltransferase
HV197_RS17465	COG2017	converts alpha-aldose to the beta-anomer
HV197_RS17475	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV197_RS17490	COG3201	nicotinamide mononucleotide transporter
HV197_RS17495	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HV197_RS17545	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HV197_RS17550	COG2885	chlorophyll binding
HV197_RS17560	COG3064	Membrane
HV197_RS17565	COG0848	biopolymer transport protein
HV197_RS17570	COG0811	peptide transport
HV197_RS17575	COG0824	Thioesterase
HV197_RS17580	COG3790	cyd operon protein YbgE
HV197_RS17585	COG4890	Cyd operon protein YbgT
HV197_RS17590	COG1294	oxidase, subunit
HV197_RS17595	COG1271	oxidase subunit
HV197_RS17600	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV197_RS17610	COG0508	dehydrogenase complex catalyzes the overall conversion of
HV197_RS17615	COG0567	Dehydrogenase, E1 component
HV197_RS17620	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HV197_RS17625	COG1053	succinate dehydrogenase
HV197_RS17630	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HV197_RS17635	COG2009	succinate dehydrogenase
HV197_RS17670	COG1984	allophanate hydrolase subunit 2
HV197_RS17675	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HV197_RS17690	COG0415	Belongs to the DNA photolyase family
HV197_RS17720	COG2205	protein histidine kinase activity
HV197_RS17725	COG0745	RESPONSE REGULATOR receiver
HV197_RS17735	COG0033	Phosphoglucomutase
HV197_RS17745	COG0596	Alpha beta hydrolase
HV197_RS17760	COG0735	belongs to the Fur family
HV197_RS17800	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV197_RS17805	COG1940	carbohydrate kinase activity
HV197_RS17805	COG1846	Transcriptional regulator
HV197_RS17810	COG0647	UMP catabolic process
HV197_RS17815	COG0367	asparagine synthase
HV197_RS17855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV197_RS17865	COG1702	phosphate starvation-inducible protein PhoH
HV197_RS17890	COG0765	amino acid transport
HV197_RS17895	COG0765	amino acid transport
HV197_RS17900	COG1126	abc transporter atp-binding protein
HV197_RS17915	COG2888	peptidyl-tyrosine sulfation
HV197_RS17930	COG1466	dna polymerase III delta subunit
HV197_RS17945	COG0799	negative regulation of ribosome biogenesis
HV197_RS17955	COG0768	penicillin binding
HV197_RS17960	COG0772	Belongs to the SEDS family
HV197_RS17965	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV197_RS17970	COG1686	Belongs to the peptidase S11 family
HV197_RS17985	COG0583	DNA-binding transcription factor activity
HV197_RS18000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV197_RS18020	COG3069	C4-dicarboxylate transmembrane transporter activity
HV197_RS18025	COG3719	Belongs to the RNase T2 family
HV197_RS18030	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HV197_RS18050	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HV197_RS18055	COG0583	DNA-binding transcription factor activity
HV197_RS18060	COG3969	phosphoadenosine phosphosulfate
HV197_RS18065	COG1475	DNA binding
HV197_RS18070	COG0436	Aminotransferase
HV197_RS18095	COG1129	ABC transporter
HV197_RS18100	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV197_RS18105	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV197_RS18115	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV197_RS18130	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HV197_RS18140	COG0402	S-adenosylhomocysteine deaminase activity
HV197_RS18150	COG0483	inositol monophosphate 1-phosphatase activity
HV197_RS18155	COG2271	Major facilitator Superfamily
HV197_RS18185	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV197_RS18190	COG1129	ABC transporter
HV197_RS18195	COG0371	Dehydrogenase
HV197_RS18200	COG1028	Short-chain dehydrogenase reductase Sdr
HV197_RS18215	COG2879	small protein
HV197_RS18220	COG1966	Carbon starvation protein
HV197_RS18230	COG1028	Short-chain dehydrogenase reductase Sdr
HV197_RS18235	COG1535	isochorismatase
HV197_RS18235	COG3433	isochorismatase activity
HV197_RS18240	COG1021	2,3-dihydroxybenzoate-AMP ligase
HV197_RS18245	COG1169	isochorismate synthase
HV197_RS18250	COG4592	Periplasmic binding protein
HV197_RS18260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV197_RS18265	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV197_RS18270	COG1120	ATPase activity
HV197_RS18275	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HV197_RS18275	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HV197_RS18280	COG3251	PFAM MbtH domain protein
HV197_RS18285	COG2382	esterase
HV197_RS18290	COG4771	TonB-dependent receptor
HV197_RS18300	COG1879	ABC-type sugar transport system periplasmic component
HV197_RS18310	COG1129	ABC transporter
HV197_RS18315	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV197_RS18320	COG5464	transposase or invertase
HV197_RS18325	COG2390	Transcriptional regulator
HV197_RS18330	COG3959	Transketolase, thiamine diphosphate binding domain
HV197_RS18335	COG3958	Transketolase
HV197_RS18345	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HV197_RS18355	COG0583	DNA-binding transcription factor activity
HV197_RS18360	COG0668	transmembrane transport
HV197_RS18370	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HV197_RS18395	COG0747	negative chemotaxis
HV197_RS18400	COG0601	transmembrane transport
HV197_RS18405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV197_RS18410	COG0444	Belongs to the ABC transporter superfamily
HV197_RS18415	COG4608	Belongs to the ABC transporter superfamily
HV197_RS18430	COG0656	L-ascorbic acid biosynthetic process
HV197_RS18450	COG4221	oxidoreductase activity
HV197_RS18460	COG4215	(ABC) transporter
HV197_RS18465	COG0765	amino acid transport
HV197_RS18470	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HV197_RS18485	COG0697	spore germination
HV197_RS18500	COG4608	Belongs to the ABC transporter superfamily
HV197_RS18505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV197_RS18515	COG4166	transmembrane transport
HV197_RS18525	COG3698	Phosphodiester glycosidase
HV197_RS18565	COG2315	Protein conserved in bacteria
HV197_RS18570	COG0778	Nitroreductase
HV197_RS18580	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV197_RS18590	COG3716	PTS system mannose fructose sorbose family IID component
HV197_RS18595	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HV197_RS18600	COG2222	sugar isomerase
HV197_RS18605	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HV197_RS18605	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HV197_RS18620	COG0477	Major facilitator Superfamily
HV197_RS18625	COG0668	transmembrane transport
HV197_RS18640	COG0673	inositol 2-dehydrogenase activity
HV197_RS18650	COG2211	Major facilitator Superfamily
HV197_RS18655	COG1113	amino acid transport
HV197_RS18670	COG1012	belongs to the aldehyde dehydrogenase family
HV197_RS18675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HV197_RS18685	COG0531	amino acid
HV197_RS18700	COG4680	protein conserved in bacteria
HV197_RS18740	COG0667	Aldo Keto reductase
HV197_RS18745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV197_RS18750	COG1473	amidohydrolase
HV197_RS18780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV197_RS18785	COG1120	ATPase activity
HV197_RS18790	COG1566	PFAM secretion protein HlyD family protein
HV197_RS18835	COG4211	Belongs to the binding-protein-dependent transport system permease family
HV197_RS18840	COG1129	ABC transporter
HV197_RS18885	COG3104	oligopeptide transport
HV197_RS18890	COG1982	Orn Lys Arg decarboxylase major
HV197_RS18895	COG0531	amino acid
HV197_RS18900	COG3710	Transcriptional regulator
HV197_RS18910	COG1560	Kdo2-lipid A biosynthetic process
HV197_RS18955	COG2501	S4 domain
HV197_RS18965	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HV197_RS18980	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HV197_RS18985	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HV197_RS19005	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HV197_RS19010	COG4181	ATPase activity
HV197_RS19015	COG2755	lipolytic protein G-D-S-L family
HV197_RS19020	COG0300	oxidoreductase activity
HV197_RS19025	COG3118	belongs to the thioredoxin family
HV197_RS19030	COG0390	transport system, permease component
HV197_RS19035	COG4619	ABC transporter
HV197_RS19040	COG0330	HflC and HflK could
HV197_RS19045	COG1585	Membrane protein implicated in regulation of membrane protease activity
HV197_RS19060	COG3735	TraB family
HV197_RS19065	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV197_RS19075	COG2223	nitrite transmembrane transporter activity
HV197_RS19080	COG4651	solute:proton antiporter activity
HV197_RS19080	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HV197_RS19085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV197_RS19125	COG2832	Protein of unknown function (DUF454)
HV197_RS19130	COG3923	Primosomal replication protein n
HV197_RS19145	COG3264	Mechanosensitive ion channel
HV197_RS19145	COG1196	nuclear chromosome segregation
HV197_RS19150	COG1309	transcriptional regulator
HV197_RS19155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV197_RS19160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV197_RS19175	COG0110	maltose O-acetyltransferase activity
HV197_RS19225	COG1874	Beta-galactosidase
HV197_RS19230	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HV197_RS19235	COG3833	ABC-type maltose transport systems, permease component
HV197_RS19240	COG1175	transmembrane transport
HV197_RS19245	COG2182	Extracellular solute-binding protein
HV197_RS19255	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV197_RS19270	COG2364	Membrane
HV197_RS19330	COG3695	enzyme binding
HV197_RS19335	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HV197_RS19340	COG1946	Acyl-CoA thioesterase
HV197_RS19345	COG0004	ammonium transporteR
HV197_RS19350	COG0347	Belongs to the P(II) protein family
HV197_RS19355	COG1132	(ABC) transporter
HV197_RS19360	COG1132	(ABC) transporter
HV197_RS19365	COG1522	sequence-specific DNA binding
HV197_RS19380	COG4533	DNA binding
HV197_RS19390	COG0824	Thioesterase
HV197_RS19395	COG1555	photosystem II stabilization
HV197_RS19400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV197_RS19405	COG0776	regulation of translation
HV197_RS19410	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HV197_RS19430	COG0271	Belongs to the BolA IbaG family
HV197_RS19435	COG3056	Lipoprotein
HV197_RS19440	COG2223	nitrite transmembrane transporter activity
HV197_RS19445	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HV197_RS19450	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HV197_RS19455	COG1845	cytochrome c oxidase, subunit III
HV197_RS19460	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HV197_RS19475	COG1414	Transcriptional regulator
HV197_RS19480	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HV197_RS19485	COG1053	succinate dehydrogenase
HV197_RS19495	COG1053	succinate dehydrogenase
HV197_RS19510	COG0673	inositol 2-dehydrogenase activity
HV197_RS19515	COG2814	Major facilitator Superfamily
HV197_RS19525	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HV197_RS19530	COG0693	protein deglycase activity
HV197_RS19550	COG0142	geranyltranstransferase activity
HV197_RS19560	COG0667	Aldo Keto reductase
HV197_RS19565	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HV197_RS19585	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HV197_RS19585	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HV197_RS19595	COG4238	major outer membrane lipoprotein
HV197_RS19615	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HV197_RS19620	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HV197_RS19625	COG1862	Preprotein translocase
HV197_RS19650	COG0450	alkyl hydroperoxide reductase
HV197_RS19655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV197_RS19670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV197_RS19680	COG1228	amidohydrolase
HV197_RS19690	COG1335	isochorismatase
HV197_RS19695	COG0583	DNA-binding transcription factor activity
HV197_RS19700	COG0366	Alpha amylase catalytic
HV197_RS19725	COG0420	3'-5' exonuclease activity
HV197_RS19730	COG0419	ATPase involved in DNA repair
HV197_RS19735	COG1940	carbohydrate kinase activity
HV197_RS19750	COG4126	flavin adenine dinucleotide binding
HV197_RS19760	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HV197_RS19765	COG3416	Protein conserved in bacteria
HV197_RS19775	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HV197_RS19785	COG1785	Belongs to the alkaline phosphatase family
HV197_RS19825	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HV197_RS19830	COG1335	isochorismatase
HV197_RS19835	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HV197_RS19840	COG0113	porphobilinogen synthase activity
HV197_RS19850	COG2175	clavaminate synthase activity
HV197_RS19855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV197_RS19860	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HV197_RS19865	COG4521	taurine ABC transporter
HV197_RS19870	COG2040	homocysteine
HV197_RS19875	COG0833	amino acid
HV197_RS19890	COG4303	Ethanolamine ammonia lyase large subunit
HV197_RS19895	COG4302	ethanolamine ammonia-lyase activity
HV197_RS19935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV197_RS19940	COG1126	abc transporter atp-binding protein
HV197_RS19945	COG4597	amino acid ABC transporter
HV197_RS19950	COG0765	amino acid transport
HV197_RS19965	COG3188	usher protein
HV197_RS19990	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HV197_RS20000	COG3639	organic phosphonate transmembrane transporter activity
HV197_RS20020	COG0791	NLP P60 protein
HV197_RS20055	COG3188	usher protein
HV197_RS20060	COG3121	Chaperone
HV197_RS20065	COG3539	Fimbrial protein
HV197_RS20090	COG3710	Transcriptional regulator
HV197_RS20125	COG2200	EAL domain
HV197_RS20145	COG3121	Chaperone
HV197_RS20170	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HV197_RS20185	COG0579	oxidoreductase
HV197_RS20190	COG1012	belongs to the aldehyde dehydrogenase family
HV197_RS20195	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV197_RS20200	COG1113	amino acid transport
HV197_RS20205	COG1802	Transcriptional regulator
HV197_RS20225	COG2195	Cleaves the N-terminal amino acid of tripeptides
HV197_RS20230	COG0454	-acetyltransferase
HV197_RS20245	COG2991	Protein conserved in bacteria
HV197_RS20260	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HV197_RS20265	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HV197_RS20280	COG3034	peptidoglycan biosynthetic process
HV197_RS20285	COG0121	glutamine amidotransferase
HV197_RS20295	COG1960	acyl-CoA dehydrogenase activity
HV197_RS20300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV197_RS20310	COG0583	DNA-binding transcription factor activity
HV197_RS20320	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV197_RS20330	COG2226	methyltransferase
HV197_RS20340	COG1388	LysM domain
HV197_RS20340	COG0741	lytic transglycosylase activity
HV197_RS20345	COG2226	methyltransferase
HV197_RS20355	COG2814	Major facilitator Superfamily
HV197_RS20360	COG0583	DNA-binding transcription factor activity
HV197_RS20365	COG0656	L-ascorbic acid biosynthetic process
HV197_RS20400	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HV197_RS20410	COG2011	ABC-type metal ion transport system permease component
HV197_RS20415	COG1464	Belongs to the NlpA lipoprotein family
HV197_RS20425	COG1720	tRNA m6t6A37 methyltransferase activity
HV197_RS20435	COG0791	NLP P60 protein
HV197_RS20440	COG3015	lipoprotein NlpE involved in copper resistance
HV197_RS20445	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HV197_RS20460	COG4568	rho-dependent transcription termination
HV197_RS20470	COG0346	lactoylglutathione lyase activity
HV197_RS20485	COG0587	DNA-directed DNA polymerase activity
HV197_RS20515	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HV197_RS20525	COG0750	zinc metalloprotease
HV197_RS20530	COG0575	Belongs to the CDS family
HV197_RS20540	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HV197_RS20565	COG0024	Methionine aminopeptidase
HV197_RS20570	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HV197_RS20585	COG3835	regulator
HV197_RS20590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV197_RS20610	COG2860	membrane
HV197_RS20630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV197_RS20635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HV197_RS20640	COG1120	ATPase activity
HV197_RS20645	COG4774	siderophore transport
HV197_RS20650	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HV197_RS20745	COG1643	Atp-dependent helicase
HV197_RS20750	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HV197_RS20770	COG0617	tRNA 3'-terminal CCA addition
HV197_RS20775	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HV197_RS20795	COG0726	polysaccharide deacetylase
HV197_RS20800	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV197_RS20805	COG0842	Transport permease protein
HV197_RS20810	COG1131	(ABC) transporter
HV197_RS20815	COG0288	reversible hydration of carbon dioxide
HV197_RS20830	COG4993	Dehydrogenase
HV197_RS20835	COG2132	Multicopper oxidase
HV197_RS20880	COG3064	Membrane
HV197_RS20895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV197_RS20900	COG0508	dehydrogenase complex catalyzes the overall conversion of
HV197_RS20905	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HV197_RS20910	COG2186	Transcriptional regulator
HV197_RS20915	COG1113	amino acid transport
HV197_RS20920	COG2211	Major facilitator Superfamily
HV197_RS20925	COG3940	Belongs to the glycosyl hydrolase 43 family
HV197_RS20930	COG3725	Membrane protein required for beta-lactamase induction
HV197_RS20935	COG3023	N-Acetylmuramoyl-L-alanine amidase
HV197_RS20945	COG4969	Belongs to the N-Me-Phe pilin family
HV197_RS20950	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HV197_RS20955	COG1459	type II secretion system
HV197_RS20980	COG0494	nUDIX hydrolase
HV197_RS21000	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HV197_RS21005	COG0849	cell division
HV197_RS21030	COG0772	Belongs to the SEDS family
HV197_RS21045	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HV197_RS21050	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HV197_RS21055	COG0768	penicillin binding
HV197_RS21075	COG1609	Transcriptional regulator
HV197_RS21085	COG0028	Belongs to the TPP enzyme family
HV197_RS21130	COG0738	Major facilitator superfamily
HV197_RS21140	COG0583	DNA-binding transcription factor activity
HV197_RS21145	COG2271	Major facilitator Superfamily
HV197_RS21150	COG2814	Major facilitator Superfamily
HV197_RS21170	COG1178	ABC-type Fe3 transport system permease component
HV197_RS21180	COG0586	Pfam SNARE associated Golgi protein
HV197_RS21200	COG0235	Class ii aldolase
HV197_RS21205	COG0417	DNA replication proofreading
HV197_RS21215	COG0564	pseudouridine synthase activity
HV197_RS21225	COG3493	citrate carrier protein
HV197_RS21240	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HV197_RS21245	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HV197_RS21255	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HV197_RS21300	COG0505	Belongs to the CarA family
HV197_RS21365	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HV197_RS21390	COG1047	Peptidyl-prolyl cis-trans
HV197_RS21405	COG0196	riboflavin kinase activity
HV197_RS21415	COG0583	DNA-binding transcription factor activity
HV197_RS21440	COG4735	regulation of single-species biofilm formation
HV197_RS21445	COG1584	GPR1 FUN34 yaaH family protein
HV197_RS21450	COG0477	Major facilitator Superfamily
HV197_RS21455	COG0521	Mo-molybdopterin cofactor biosynthetic process
HV197_RS21460	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HV197_RS21465	COG1115	amino acid carrier protein
HV197_RS21480	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HV197_RS21490	COG0460	homoserine dehydrogenase
HV197_RS21490	COG0527	aspartate kinase activity
HV197_RS21500	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HV197_RS21510	COG0745	RESPONSE REGULATOR receiver
HV197_RS21515	COG4452	Inner membrane protein CreD
HV197_RS21520	COG2205	protein histidine kinase activity
HV197_RS21525	COG0745	RESPONSE REGULATOR receiver
HV197_RS21530	COG3045	CreA protein
HV197_RS21535	COG2207	Transcriptional regulator
HV197_RS21535	COG3708	Transcriptional regulator
HV197_RS21555	COG0741	lytic transglycosylase activity
HV197_RS21560	COG0488	(ABC) transporter
HV197_RS21570	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HV197_RS21575	COG0560	Phosphoserine phosphatase
HV197_RS21580	COG3726	membrane protein affecting hemolysin expression
HV197_RS21610	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV197_RS21615	COG0084	hydrolase, TatD family'
HV197_RS21620	COG4667	esterase of the alpha-beta hydrolase superfamily
HV197_RS21630	COG2823	Periplasmic or secreted lipoprotein
HV197_RS21640	COG1011	Hydrolase
HV197_RS21645	COG0456	acetyltransferase
HV197_RS21650	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HV197_RS21685	COG3706	GGDEF domain
HV197_RS21690	COG4114	ferric iron reductase
HV197_RS21695	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV197_RS21695	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV197_RS21700	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV197_RS21705	COG2197	response regulator
HV197_RS21710	COG2197	response regulator
HV197_RS21725	COG2966	Psort location CytoplasmicMembrane, score
HV197_RS21740	COG1484	DNA-dependent DNA replication
HV197_RS21755	COG5464	transposase or invertase
HV197_RS21765	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HV197_RS21770	COG3716	PTS system mannose fructose sorbose family IID component
HV197_RS21775	COG3715	PTS system
HV197_RS21790	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HV197_RS21790	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HV197_RS21795	COG0456	acetyltransferase
HV197_RS21795	COG1214	PFAM Peptidase M22, glycoprotease
HV197_RS21805	COG1737	Transcriptional regulator
HV197_RS21810	COG0800	Aldolase
HV197_RS21815	COG3734	2-keto-3-deoxy-galactonokinase
HV197_RS21820	COG4145	pantothenate transmembrane transporter activity
HV197_RS21830	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HV197_RS21850	COG0531	amino acid
HV197_RS21855	COG1012	belongs to the aldehyde dehydrogenase family
HV197_RS21860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HV197_RS21875	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HV197_RS21875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HV197_RS21890	COG1846	Transcriptional regulator
HV197_RS21900	COG0179	Fumarylacetoacetate (FAA) hydrolase
HV197_RS21910	COG1012	belongs to the aldehyde dehydrogenase family
HV197_RS21915	COG3384	dioxygenase
HV197_RS21925	COG3971	2-oxopent-4-enoate hydratase activity
HV197_RS21945	COG2368	4-hydroxyphenylacetate
HV197_RS21950	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HV197_RS21955	COG1966	Carbon starvation protein
HV197_RS21960	COG2879	small protein
HV197_RS21965	COG0523	cobalamin synthesis protein
HV197_RS21975	COG1012	belongs to the aldehyde dehydrogenase family
HV197_RS21980	COG5464	transposase or invertase
HV197_RS21985	COG2207	Transcriptional regulator
HV197_RS21985	COG1917	Cupin 2, conserved barrel domain protein
HV197_RS21995	COG2733	membrane
HV197_RS22010	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HV197_RS22015	COG1924	4 iron, 4 sulfur cluster binding
HV197_RS22030	COG1566	PFAM secretion protein HlyD family protein
HV197_RS22040	COG5457	Domain of unknown function (DUF1127)
HV197_RS22045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV197_RS22055	COG0583	DNA-binding transcription factor activity
HV197_RS22060	COG2249	NAD(P)H dehydrogenase (quinone) activity
HV197_RS22095	COG1454	alcohol dehydrogenase
HV197_RS22095	COG1012	belongs to the aldehyde dehydrogenase family
HV197_RS22110	COG1882	Formate acetyltransferase
HV197_RS22115	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV197_RS22125	COG4869	propanediol catabolic process
HV197_RS22150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV197_RS22155	COG0842	Transport permease protein
HV197_RS22155	COG1129	ABC transporter
HV197_RS22160	COG0842	Transport permease protein
HV197_RS22190	COG2850	peptidyl-arginine hydroxylation
HV197_RS22205	COG5002	protein histidine kinase activity
HV197_RS22210	COG0745	RESPONSE REGULATOR receiver
HV197_RS22215	COG1538	Outer membrane efflux protein
HV197_RS22220	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV197_RS22225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV197_RS22230	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV197_RS22240	COG3040	lipid binding
HV197_RS22245	COG0789	Transcriptional regulator
HV197_RS22255	COG0300	oxidoreductase activity
HV197_RS22270	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HV197_RS22290	COG3272	Protein of unknown function (DUF1722)
HV197_RS22295	COG4580	involved in the transport of maltose and maltodextrins
HV197_RS22300	COG2115	Belongs to the xylose isomerase family
HV197_RS22305	COG2211	Major facilitator Superfamily
HV197_RS22310	COG3507	Belongs to the glycosyl hydrolase 43 family
HV197_RS22330	COG1216	Glycosyl transferase, family 2
HV197_RS22385	COG2003	Belongs to the UPF0758 family
HV197_RS22415	COG0210	DNA helicase
HV197_RS22480	COG0582	viral genome integration into host DNA
HV197_RS22490	COG0288	reversible hydration of carbon dioxide
HV197_RS22495	COG0659	secondary active sulfate transmembrane transporter activity
HV197_RS22500	COG1064	alcohol dehydrogenase
HV197_RS22505	COG1175	transmembrane transport
HV197_RS22510	COG0395	ABC-type sugar transport system, permease component
HV197_RS22515	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HV197_RS22520	COG3842	ATPase activity
HV197_RS22535	COG1082	Xylose isomerase domain protein TIM barrel
HV197_RS22545	COG3962	Belongs to the TPP enzyme family
HV197_RS22550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV197_RS22555	COG1737	Transcriptional regulator
HV197_RS22555	COG0837	glucose binding
HV197_RS22560	COG3718	enzyme involved in inositol metabolism
HV197_RS22575	COG0433	COG0433 Predicted ATPase
HV197_RS22580	COG0795	lipopolysaccharide-transporting ATPase activity
HV197_RS22585	COG0795	lipopolysaccharide-transporting ATPase activity
HV197_RS22595	COG2927	DNA polymerase III (CHI subunit)
HV197_RS22600	COG0525	valine-tRNA ligase activity
HV197_RS22625	COG2188	Transcriptional regulator
HV197_RS22630	COG1288	antiporter activity
HV197_RS22635	COG1228	amidohydrolase
HV197_RS22640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV197_RS22645	COG2222	sugar isomerase
HV197_RS22650	COG2731	YhcH YjgK YiaL family protein
HV197_RS22685	COG1263	PTS System
HV197_RS22685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV197_RS22690	COG0366	Alpha amylase catalytic
HV197_RS22695	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV197_RS22700	COG1486	melibiose metabolic process
HV197_RS22725	COG0602	queuosine metabolic process
HV197_RS22730	COG2026	Addiction module toxin, RelE StbE family
HV197_RS22735	COG3077	Addiction module antitoxin, RelB DinJ family
HV197_RS22740	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV197_RS22740	COG3711	transcriptional antiterminator
HV197_RS22745	COG2706	6-phosphogluconolactonase activity
HV197_RS22760	COG3964	amidohydrolase
HV197_RS22795	COG0312	modulator of DNA gyrase
HV197_RS22815	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HV197_RS22825	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV197_RS22830	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV197_RS22835	COG1129	ABC transporter
HV197_RS22840	COG1879	ABC-type sugar transport system periplasmic component
HV197_RS22865	COG2105	PFAM AIG2 family protein
HV197_RS22870	COG2911	Protein conserved in bacteria
HV197_RS22875	COG0729	surface antigen
HV197_RS22885	COG1253	flavin adenine dinucleotide binding
HV197_RS22910	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HV197_RS22925	COG1733	regulation of RNA biosynthetic process
HV197_RS22930	COG0702	epimerase
HV197_RS22940	COG0697	spore germination
HV197_RS22950	COG1113	amino acid transport
HV197_RS22955	COG0545	Peptidyl-prolyl cis-trans isomerase
HV197_RS22960	COG3061	Opacity-associated protein A
HV197_RS22970	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HV197_RS22975	COG2965	DNA replication, synthesis of RNA primer
HV197_RS23035	COG1073	alpha beta
HV197_RS23040	COG3650	response to hydrogen peroxide
HV197_RS23050	COG1960	acyl-CoA dehydrogenase activity
HV197_RS23055	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV197_RS23060	COG0557	exoribonuclease II activity
HV197_RS23075	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HV197_RS23085	COG0330	HflC and HflK could
HV197_RS23090	COG0330	HflC and HflK could
HV197_RS23095	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HV197_RS23115	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV197_RS23120	COG0802	atpase or kinase
HV197_RS23125	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HV197_RS23125	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HV197_RS23130	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HV197_RS23150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV197_RS23170	COG3264	Mechanosensitive ion channel
HV197_RS23170	COG1511	domain protein
HV197_RS23185	COG1053	succinate dehydrogenase
HV197_RS23190	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HV197_RS23210	COG2076	Multidrug Resistance protein
HV197_RS23215	COG5510	response to toxic substance
HV197_RS23230	COG1509	lysine 2,3-aminomutase activity
HV197_RS23235	COG0745	RESPONSE REGULATOR receiver
HV197_RS23290	COG3539	Fimbrial protein
HV197_RS23310	COG0531	amino acid
HV197_RS23315	COG3030	protein affecting phage T7 exclusion by the F plasmid
HV197_RS23320	COG1027	Aspartate ammonia-lyase
HV197_RS23325	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV197_RS23340	COG1309	transcriptional regulator
HV197_RS23370	COG0457	Tetratricopeptide repeat
HV197_RS23375	COG0726	polysaccharide deacetylase
HV197_RS23375	COG1649	PFAM Uncharacterised BCR, COG1649
HV197_RS23380	COG1215	transferase activity, transferring glycosyl groups
HV197_RS23395	COG0861	Integral membrane protein TerC family
HV197_RS23435	COG1486	melibiose metabolic process
HV197_RS23440	COG2169	Transcriptional regulator
HV197_RS23450	COG2824	Alkylphosphonate utilization operon protein PhnA
HV197_RS23455	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HV197_RS23460	COG2188	Transcriptional regulator
HV197_RS23465	COG3624	Phosphonate C-P lyase system protein PhnG
HV197_RS23470	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HV197_RS23475	COG3626	phosphonate metabolism
HV197_RS23480	COG3627	carbon phosphorus lyase activity
HV197_RS23485	COG4107	phosphonate C-P lyase system protein PhnK
HV197_RS23490	COG4778	phosphonate C-P lyase system protein PhnL
HV197_RS23495	COG3454	Phosphonate metabolism
HV197_RS23505	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HV197_RS23515	COG0784	Response regulator, receiver
HV197_RS23515	COG4191	Histidine kinase
HV197_RS23520	COG1129	ABC transporter
HV197_RS23525	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV197_RS23560	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HV197_RS23565	COG1301	dicarboxylic acid transport
HV197_RS23575	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HV197_RS23580	COG3162	membrane
HV197_RS23610	COG3539	Fimbrial protein
HV197_RS23615	COG1346	cytolysis
HV197_RS23620	COG1380	Effector of murein hydrolase LrgA
HV197_RS23625	COG0583	DNA-binding transcription factor activity
HV197_RS23630	COG0025	NhaP-type Na H and K H
HV197_RS23635	COG2252	PERMEase
HV197_RS23640	COG0625	glutathione transferase activity
HV197_RS23645	COG0789	Transcriptional regulator
HV197_RS23655	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV197_RS23685	COG1234	tRNA 3'-trailer cleavage
HV197_RS23690	COG1609	Transcriptional regulator
HV197_RS23695	COG0483	inositol monophosphate 1-phosphatase activity
HV197_RS23705	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV197_RS23725	COG4771	TonB-dependent receptor
HV197_RS23730	COG0741	lytic transglycosylase activity
HV197_RS23745	COG2315	Protein conserved in bacteria
HV197_RS23750	COG0432	Pfam Uncharacterised protein family UPF0047
HV197_RS23765	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HV197_RS23770	COG0305	Participates in initiation and elongation during chromosome replication
HV197_RS23785	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HV197_RS23795	COG0735	belongs to the Fur family
HV197_RS23800	COG3237	CsbD-like
HV197_RS23810	COG0534	Mate efflux family protein
HV197_RS23820	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HV197_RS23890	COG0251	oxidation-reduction process
HV197_RS23900	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HV197_RS23910	COG0527	aspartate kinase activity
HV197_RS23965	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HV197_RS23995	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HV197_RS24005	COG0456	acetyltransferase
HV197_RS24035	COG0151	Belongs to the GarS family
HV197_RS24045	COG4191	Histidine kinase
HV197_RS24050	COG3678	ATP-independent chaperone mediated protein folding
HV197_RS24085	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HV197_RS24100	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HV197_RS24105	COG2104	thiamine diphosphate biosynthetic process
HV197_RS24120	COG3706	GGDEF domain
HV197_RS24130	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV197_RS24135	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV197_RS24170	COG0250	Participates in transcription elongation, termination and antitermination
HV197_RS24275	COG0583	DNA-binding transcription factor activity
HV197_RS24290	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HV197_RS24305	COG3443	Belongs to the bacterial solute-binding protein 9 family
HV197_RS24310	COG2207	Transcriptional regulator
HV197_RS24320	COG0371	Dehydrogenase
HV197_RS24325	COG0697	spore germination
HV197_RS24335	COG0583	DNA-binding transcription factor activity
HV197_RS24345	COG0737	Belongs to the 5'-nucleotidase family
HV197_RS24355	COG0527	aspartate kinase activity
HV197_RS24355	COG0460	homoserine dehydrogenase
HV197_RS24360	COG0626	cystathionine gamma-synthase activity
HV197_RS24375	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HV197_RS24380	COG1609	Transcriptional regulator
HV197_RS24385	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV197_RS24400	COG1575	Belongs to the MenA family. Type 1 subfamily
HV197_RS24420	COG3678	ATP-independent chaperone mediated protein folding
HV197_RS24425	COG0745	RESPONSE REGULATOR receiver
HV197_RS24430	COG2205	protein histidine kinase activity
HV197_RS24435	COG2258	MOSC domain
HV197_RS24440	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HV197_RS24485	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV197_RS24495	COG1454	alcohol dehydrogenase
HV197_RS24505	COG2211	Major facilitator Superfamily
HV197_RS24550	COG0437	4 iron, 4 sulfur cluster binding
HV197_RS24555	COG2864	formate dehydrogenase
HV197_RS24570	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV197_RS24580	COG0456	acetyltransferase
HV197_RS24595	COG1011	Hydrolase
HV197_RS24610	COG3852	Histidine kinase
HV197_RS24625	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HV197_RS24645	COG0204	Acyl-transferase
HV197_RS24655	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HV197_RS24660	COG3084	Protein conserved in bacteria
HV197_RS24670	COG1763	Mo-molybdopterin cofactor biosynthetic process
HV197_RS24700	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HV197_RS24710	COG1739	Uncharacterized protein family UPF0029
HV197_RS24750	COG0805	protein transport
HV197_RS24770	COG3165	ubiquinone biosynthetic process from chorismate
HV197_RS24800	COG0583	DNA-binding transcription factor activity
HV197_RS24805	COG0697	spore germination
HV197_RS24810	COG0561	phosphatase activity
HV197_RS24815	COG2267	carboxylic ester hydrolase activity
HV197_RS24820	COG1280	lysine exporter protein (LysE YggA)
HV197_RS24830	COG1280	lysine exporter protein (LysE YggA)
HV197_RS24860	COG0210	DNA helicase
HV197_RS24865	COG1011	Hydrolase
HV197_RS24895	COG3072	Adenylate cyclase
HV197_RS24910	COG2959	enzyme of heme biosynthesis
HV197_RS24915	COG3071	HemY protein
HV197_RS24960	COG2244	polysaccharide biosynthetic process
HV197_RS24965	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HV197_RS24970	COG0456	acetyltransferase
HV197_RS24975	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HV197_RS24980	COG1088	dTDP-glucose 4,6-dehydratase activity
HV197_RS24985	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HV197_RS24990	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HV197_RS25000	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HV197_RS25005	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HV197_RS25010	COG3118	belongs to the thioredoxin family
HV197_RS25035	COG1811	Na channel or pump
HV197_RS25045	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV197_RS25050	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV197_RS25060	COG0583	DNA-binding transcription factor activity
HV197_RS25065	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HV197_RS25080	COG3978	acetolactate synthase activity
HV197_RS25100	COG3085	chromosome segregation
HV197_RS25140	COG2186	Transcriptional regulator
HV197_RS25145	COG0477	Major facilitator Superfamily
HV197_RS25150	COG1609	Transcriptional regulator
HV197_RS25155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV197_RS25165	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV197_RS25170	COG1129	ABC transporter
HV197_RS25200	COG1522	sequence-specific DNA binding
HV197_RS25205	COG0716	FMN binding
HV197_RS25220	COG3312	ion transport
HV197_RS25270	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HV197_RS25275	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HV197_RS25280	COG0573	inorganic phosphate transmembrane transporter activity
HV197_RS25285	COG0581	inorganic phosphate transmembrane transporter activity
HV197_RS25290	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HV197_RS25295	COG0704	Plays a role in the regulation of phosphate uptake
HV197_RS25305	COG2382	esterase
HV197_RS25310	COG0363	glucosamine-6-phosphate deaminase activity
HV197_RS25315	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV197_RS25320	COG2252	PERMEase
HV197_RS25325	COG0431	NADPH-dependent FMN reductase
HV197_RS25330	COG2091	lysine biosynthetic process via aminoadipic acid
HV197_RS25360	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HV197_RS25410	COG4644	lycopene metabolic process
HV197_RS25545	COG3344	reverse transcriptase
HV197_RS25770	COG1609	Transcriptional regulator
HV197_RS25780	COG2223	nitrite transmembrane transporter activity
HV197_RS25815	COG2135	peptidase activity
HV197_RS25835	COG2801	Transposase and inactivated derivatives
HV197_RS25855	COG2944	sequence-specific DNA binding
HV197_RS25940	COG3039	Transposase
HV197_RS25945	COG2197	response regulator
HV197_RS25985	COG2199	diguanylate cyclase activity
HV197_RS25985	COG2203	Gaf domain
HV197_RS25990	COG1716	ATPase activity
HV197_RS25990	COG5001	Diguanylate cyclase
HV197_RS26005	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV197_RS26015	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HV197_RS26045	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV197_RS26075	COG0739	heme binding
HV197_RS26085	COG2132	Multicopper oxidase
HV197_RS26090	COG3667	copper resistance
HV197_RS26095	COG2372	response to copper ion
HV197_RS26100	COG1276	copper resistance
HV197_RS26105	COG0745	RESPONSE REGULATOR receiver
HV197_RS26110	COG2205	protein histidine kinase activity
HV197_RS26125	COG3436	PFAM IS66 Orf2 family protein
HV197_RS26130	COG4372	Transposase
HV197_RS26140	COG4172	Belongs to the ABC transporter superfamily
HV197_RS26155	COG0601	transmembrane transport
HV197_RS26160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV197_RS26190	COG1595	DNA-templated transcription, initiation
HV197_RS26195	COG3712	iron ion homeostasis
HV197_RS26200	COG4772	TonB-dependent receptor
HV197_RS26205	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HV197_RS26210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV197_RS26215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV197_RS26220	COG1120	ATPase activity
HV197_RS26225	COG3436	PFAM IS66 Orf2 family protein
HV197_RS26280	COG3039	Transposase
HV197_RS26285	COG1528	Iron-storage protein
HV197_RS26325	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HV197_RS26330	COG3318	Belongs to the UPF0149 family
HV197_RS26330	COG3012	SEC-C Motif Domain Protein
HV197_RS26355	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities