locus-tag	class	description
HV239_RS00020	COG0187	DNA topoisomerase II activity
HV239_RS00025	COG0561	phosphatase activity
HV239_RS00040	COG2186	Transcriptional regulator
HV239_RS00045	COG3734	2-keto-3-deoxy-galactonokinase
HV239_RS00050	COG0800	Aldolase
HV239_RS00060	COG2271	Major facilitator Superfamily
HV239_RS00065	COG0823	Involved in the tonB-independent uptake of proteins
HV239_RS00070	COG5645	(Lipo)protein
HV239_RS00085	COG3645	SOS response
HV239_RS00095	COG2188	Transcriptional regulator
HV239_RS00110	COG2149	membrane
HV239_RS00130	COG2610	gluconate transmembrane transporter activity
HV239_RS00140	COG0583	DNA-binding transcription factor activity
HV239_RS00145	COG2814	Major facilitator Superfamily
HV239_RS00175	COG0028	Belongs to the TPP enzyme family
HV239_RS00180	COG0440	acetolactate synthase activity
HV239_RS00185	COG2197	response regulator
HV239_RS00195	COG2271	Major facilitator Superfamily
HV239_RS00235	COG2188	Transcriptional regulator
HV239_RS00260	COG4580	involved in the transport of maltose and maltodextrins
HV239_RS00265	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV239_RS00270	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV239_RS00270	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV239_RS00280	COG1609	Transcriptional regulator
HV239_RS00290	COG3384	dioxygenase
HV239_RS00295	COG0583	DNA-binding transcription factor activity
HV239_RS00300	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HV239_RS00305	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HV239_RS00310	COG2828	Protein conserved in bacteria
HV239_RS00325	COG0697	spore germination
HV239_RS00330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV239_RS00330	COG1263	PTS System
HV239_RS00340	COG2814	Major facilitator Superfamily
HV239_RS00350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV239_RS00385	COG0583	DNA-binding transcription factor activity
HV239_RS00410	COG1464	Belongs to the NlpA lipoprotein family
HV239_RS00425	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HV239_RS00435	COG1064	alcohol dehydrogenase
HV239_RS00465	COG2211	Major facilitator Superfamily
HV239_RS00470	COG1501	Belongs to the glycosyl hydrolase 31 family
HV239_RS00480	COG1486	melibiose metabolic process
HV239_RS00485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV239_RS00485	COG1263	PTS System
HV239_RS00490	COG2982	Protein involved in outer membrane biogenesis
HV239_RS00495	COG2233	PERMEase
HV239_RS00500	COG0786	glutamate:sodium symporter activity
HV239_RS00520	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HV239_RS00545	COG3152	Membrane
HV239_RS00555	COG1494	fructose-1,6-bisphosphatase
HV239_RS00560	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HV239_RS00565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV239_RS00570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV239_RS00590	COG2860	membrane
HV239_RS00600	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HV239_RS00600	COG2169	Transcriptional regulator
HV239_RS00605	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HV239_RS00650	COG1561	YicC-like family, N-terminal region
HV239_RS00670	COG1131	(ABC) transporter
HV239_RS00675	COG0842	Transport permease protein
HV239_RS00705	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HV239_RS00740	COG1519	Transferase
HV239_RS00745	COG1216	Glycosyl transferase, family 2
HV239_RS00750	COG0438	transferase activity, transferring glycosyl groups
HV239_RS00760	COG0859	PFAM glycosyl transferase family 9
HV239_RS00770	COG1216	Glycosyl transferase, family 2
HV239_RS00770	COG1442	glycosyl transferase family 8
HV239_RS00775	COG3307	-O-antigen
HV239_RS00780	COG0438	transferase activity, transferring glycosyl groups
HV239_RS00785	COG0859	PFAM glycosyl transferase family 9
HV239_RS00800	COG0156	8-amino-7-oxononanoate synthase activity
HV239_RS00810	COG0463	Glycosyl transferase, family 2
HV239_RS00815	COG2861	carbohydrate metabolic process
HV239_RS00820	COG4942	peptidase
HV239_RS00830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV239_RS00835	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HV239_RS00855	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HV239_RS00865	COG2186	Transcriptional regulator
HV239_RS00885	COG3722	fumarate hydratase activity
HV239_RS00900	COG0625	glutathione transferase activity
HV239_RS00910	COG3276	selenocysteine insertion sequence binding
HV239_RS00915	COG1414	Transcriptional regulator
HV239_RS00920	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV239_RS00925	COG3977	Valine--pyruvate aminotransferase
HV239_RS00930	COG0366	Alpha amylase catalytic
HV239_RS00935	COG2992	FlgJ-related protein
HV239_RS00940	COG1609	Transcriptional regulator
HV239_RS00940	COG2207	Transcriptional regulator
HV239_RS00945	COG4214	carbohydrate transport
HV239_RS00955	COG4213	ABC transporter substrate-binding protein
HV239_RS00970	COG4682	membrane
HV239_RS00975	COG4682	membrane
HV239_RS00980	COG3274	enterobacterial common antigen metabolic process
HV239_RS01020	COG1278	Cold shock
HV239_RS01025	COG2944	sequence-specific DNA binding
HV239_RS01030	COG2814	Major facilitator Superfamily
HV239_RS01050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV239_RS01060	COG1609	Transcriptional regulator
HV239_RS01065	COG2885	chlorophyll binding
HV239_RS01070	COG0243	molybdopterin cofactor binding
HV239_RS01075	COG0456	acetyltransferase
HV239_RS01080	COG2818	Glycosylase
HV239_RS01085	COG5571	outer membrane autotransporter
HV239_RS01090	COG2223	nitrite transmembrane transporter activity
HV239_RS01115	COG0747	negative chemotaxis
HV239_RS01120	COG0601	transmembrane transport
HV239_RS01125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV239_RS01130	COG0444	Belongs to the ABC transporter superfamily
HV239_RS01135	COG4608	Belongs to the ABC transporter superfamily
HV239_RS01150	COG2894	cell division
HV239_RS01160	COG1215	transferase activity, transferring glycosyl groups
HV239_RS01165	COG0457	Tetratricopeptide repeat
HV239_RS01180	COG2194	sulfuric ester hydrolase activity
HV239_RS01210	COG1215	transferase activity, transferring glycosyl groups
HV239_RS01215	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HV239_RS01220	COG3118	belongs to the thioredoxin family
HV239_RS01220	COG0457	Tetratricopeptide repeat
HV239_RS01225	COG2200	EAL domain
HV239_RS01225	COG2199	diguanylate cyclase activity
HV239_RS01235	COG0612	Peptidase, M16
HV239_RS01245	COG2982	Protein involved in outer membrane biogenesis
HV239_RS01250	COG0477	Major facilitator Superfamily
HV239_RS01255	COG1295	ribonuclease BN
HV239_RS01260	COG0583	DNA-binding transcription factor activity
HV239_RS01265	COG1028	Short-chain dehydrogenase reductase Sdr
HV239_RS01270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV239_RS01280	COG1454	alcohol dehydrogenase
HV239_RS01290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV239_RS01295	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HV239_RS01300	COG0671	phosphoesterase, PA-phosphatase related
HV239_RS01320	COG0589	response to stress
HV239_RS01330	COG0306	phosphate transporter
HV239_RS01335	COG2081	HI0933 family
HV239_RS01340	COG2239	Acts as a magnesium transporter
HV239_RS01355	COG1124	(ABC) transporter
HV239_RS01365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV239_RS01370	COG0601	transmembrane transport
HV239_RS01375	COG0747	negative chemotaxis
HV239_RS01385	COG3479	Phenolic acid decarboxylase
HV239_RS01425	COG0628	permease
HV239_RS01430	COG0477	Major facilitator Superfamily
HV239_RS01440	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HV239_RS01455	COG3714	YhhN family
HV239_RS01465	COG3776	membrane
HV239_RS01470	COG0742	ribosomal rna small subunit methyltransferase
HV239_RS01475	COG0552	protein localization to endoplasmic reticulum
HV239_RS01480	COG2884	Cell division ATP-binding protein ftsE
HV239_RS01485	COG2177	Part of the ABC transporter FtsEX involved in
HV239_RS01500	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV239_RS01515	COG0683	leucine binding
HV239_RS01520	COG4907	membrane protein (DUF2207)
HV239_RS01525	COG1704	LemA family
HV239_RS01530	COG0456	acetyltransferase
HV239_RS01535	COG0683	leucine binding
HV239_RS01540	COG0559	Belongs to the binding-protein-dependent transport system permease family
HV239_RS01590	COG0584	glycerophosphoryl diester phosphodiesterase
HV239_RS01600	COG0405	Gamma-glutamyltransferase
HV239_RS01605	COG1247	-acetyltransferase
HV239_RS01615	COG0673	inositol 2-dehydrogenase activity
HV239_RS01620	COG1741	Belongs to the pirin family
HV239_RS01625	COG1609	Transcriptional regulator
HV239_RS01630	COG3265	gluconokinase activity
HV239_RS01635	COG2610	gluconate transmembrane transporter activity
HV239_RS01645	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HV239_RS01670	COG0058	SHG alpha-glucan phosphorylase activity
HV239_RS01675	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HV239_RS01690	COG1349	DNA-binding transcription factor activity
HV239_RS01700	COG0058	SHG alpha-glucan phosphorylase activity
HV239_RS01705	COG1640	4-alpha-glucanotransferase
HV239_RS01710	COG2610	gluconate transmembrane transporter activity
HV239_RS01720	COG1040	competence protein
HV239_RS01745	COG1918	ferrous iron import across plasma membrane
HV239_RS01750	COG2183	response to ionizing radiation
HV239_RS01755	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HV239_RS01760	COG0745	RESPONSE REGULATOR receiver
HV239_RS01780	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HV239_RS01785	COG1011	Hydrolase
HV239_RS01795	COG0494	nUDIX hydrolase
HV239_RS01800	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HV239_RS01825	COG4796	Type ii and iii secretion system protein
HV239_RS01840	COG3266	domain, Protein
HV239_RS01845	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HV239_RS01850	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HV239_RS01875	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HV239_RS01880	COG0402	S-adenosylhomocysteine deaminase activity
HV239_RS01885	COG0738	Major facilitator superfamily
HV239_RS01910	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HV239_RS01915	COG1289	transmembrane transporter activity
HV239_RS01925	COG1765	OsmC-like protein
HV239_RS01930	COG3954	Phosphoribulokinase
HV239_RS01940	COG0429	hydrolase of the alpha beta-hydrolase fold
HV239_RS01945	COG0488	(ABC) transporter
HV239_RS01960	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HV239_RS01965	COG1047	Peptidyl-prolyl cis-trans
HV239_RS01975	COG0545	Peptidyl-prolyl cis-trans isomerase
HV239_RS01980	COG2964	Protein conserved in bacteria
HV239_RS02035	COG0051	transcription antitermination factor activity, RNA binding
HV239_RS02060	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HV239_RS02075	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HV239_RS02140	COG0201	protein transport
HV239_RS02165	COG0202	RNA polymerase activity
HV239_RS02180	COG0789	Transcriptional regulator
HV239_RS02185	COG3036	rescue of stalled ribosome
HV239_RS02215	COG0758	DNA mediated transformation
HV239_RS02225	COG0551	DNA topoisomerase type I activity
HV239_RS02245	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV239_RS02280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV239_RS02285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV239_RS02290	COG1309	transcriptional regulator
HV239_RS02310	COG4145	pantothenate transmembrane transporter activity
HV239_RS02315	COG3924	membrane
HV239_RS02320	COG0439	Biotin carboxylase
HV239_RS02325	COG0511	ligase activity, forming carbon-carbon bonds
HV239_RS02350	COG2199	diguanylate cyclase activity
HV239_RS02350	COG2200	EAL domain
HV239_RS02355	COG1077	Cell shape determining protein MreB Mrl
HV239_RS02360	COG1792	Involved in formation and maintenance of cell shape
HV239_RS02365	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HV239_RS02375	COG1530	ribonuclease E activity
HV239_RS02380	COG3164	Protein of unknown function
HV239_RS02385	COG0312	modulator of DNA gyrase
HV239_RS02390	COG0583	DNA-binding transcription factor activity
HV239_RS02405	COG1289	transmembrane transporter activity
HV239_RS02410	COG2732	(Barnase) inhibitor
HV239_RS02435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV239_RS02440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV239_RS02445	COG3105	Protein conserved in bacteria
HV239_RS02450	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HV239_RS02470	COG0625	glutathione transferase activity
HV239_RS02475	COG2969	positive regulation of protein catabolic process
HV239_RS02485	COG0493	'glutamate synthase
HV239_RS02490	COG0067	glutamate synthase
HV239_RS02490	COG0069	glutamate synthase activity
HV239_RS02490	COG0070	glutamate synthase
HV239_RS02495	COG1242	4 iron, 4 sulfur cluster binding
HV239_RS02500	COG2271	Major facilitator Superfamily
HV239_RS02505	COG1063	alcohol dehydrogenase
HV239_RS02510	COG1312	Catalyzes the dehydration of D-mannonate
HV239_RS02515	COG5002	protein histidine kinase activity
HV239_RS02515	COG2198	Histidine kinase
HV239_RS02515	COG0784	Response regulator, receiver
HV239_RS02520	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HV239_RS02525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HV239_RS02530	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV239_RS02540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV239_RS02545	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HV239_RS02550	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HV239_RS02555	COG1137	ATPase activity
HV239_RS02560	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HV239_RS02565	COG3117	lipopolysaccharide transmembrane transporter activity
HV239_RS02570	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HV239_RS02580	COG0530	calcium, potassium:sodium antiporter activity
HV239_RS02585	COG1127	ABC transporter
HV239_RS02590	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HV239_RS02595	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HV239_RS02600	COG2854	intermembrane phospholipid transfer
HV239_RS02605	COG3113	response to antibiotic
HV239_RS02610	COG5007	Belongs to the BolA IbaG family
HV239_RS02620	COG3423	Transcriptional regulator
HV239_RS02625	COG0142	geranyltranstransferase activity
HV239_RS02640	COG0697	spore germination
HV239_RS02650	COG2027	D-alanyl-D-alanine carboxypeptidase
HV239_RS02660	COG1534	Rna-binding protein
HV239_RS02670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HV239_RS02675	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HV239_RS02685	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HV239_RS02725	COG0195	Participates in both transcription termination and antitermination
HV239_RS02770	COG0814	amino acid
HV239_RS02775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV239_RS02780	COG0826	peptidase U32
HV239_RS02785	COG0826	peptidase U32
HV239_RS02790	COG3154	lipid carrier protein
HV239_RS02795	COG3153	acetyltransferase
HV239_RS02810	COG0693	protein deglycase activity
HV239_RS02815	COG0702	epimerase
HV239_RS02820	COG0701	Predicted permease
HV239_RS02825	COG2823	Periplasmic or secreted lipoprotein
HV239_RS02845	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HV239_RS02850	COG2721	sulfolactate sulfo-lyase activity
HV239_RS02855	COG2271	Major facilitator Superfamily
HV239_RS02865	COG2084	Dehydrogenase
HV239_RS02870	COG1929	Belongs to the glycerate kinase type-1 family
HV239_RS02895	COG1741	Belongs to the pirin family
HV239_RS02900	COG0583	DNA-binding transcription factor activity
HV239_RS02905	COG3152	Membrane
HV239_RS02910	COG0435	Glutathione S-transferase
HV239_RS02915	COG2259	Doxx family
HV239_RS02925	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HV239_RS02930	COG4575	ribosome binding
HV239_RS02935	COG1422	Protein of unknown function (DUF1090)
HV239_RS02945	COG0586	Pfam SNARE associated Golgi protein
HV239_RS02950	COG2186	Transcriptional regulator
HV239_RS02955	COG2271	Major facilitator Superfamily
HV239_RS02965	COG2721	sulfolactate sulfo-lyase activity
HV239_RS02980	COG0861	Integral membrane protein TerC family
HV239_RS02985	COG0673	inositol 2-dehydrogenase activity
HV239_RS02990	COG1451	nucleotide metabolic process
HV239_RS03010	COG1902	pentaerythritol trinitrate reductase activity
HV239_RS03010	COG0446	pyridine nucleotide-disulphide oxidoreductase
HV239_RS03060	COG1695	Transcriptional regulator
HV239_RS03065	COG2375	cellular response to nickel ion
HV239_RS03080	COG1461	Dihydroxyacetone kinase
HV239_RS03085	COG2376	Dihydroxyacetone kinase
HV239_RS03155	COG3247	response to pH
HV239_RS03170	COG2197	response regulator
HV239_RS03195	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HV239_RS03200	COG0358	DNA primase activity
HV239_RS03205	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HV239_RS03270	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HV239_RS03285	COG4991	sh3 domain protein
HV239_RS03290	COG3025	triphosphatase activity
HV239_RS03315	COG2960	long-chain fatty acid transporting porin activity
HV239_RS03330	COG3384	dioxygenase
HV239_RS03335	COG0754	glutathionylspermidine amidase activity
HV239_RS03350	COG0494	nUDIX hydrolase
HV239_RS03355	COG3151	Protein conserved in bacteria
HV239_RS03360	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HV239_RS03365	COG3150	esterase
HV239_RS03375	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HV239_RS03380	COG2249	NAD(P)H dehydrogenase (quinone) activity
HV239_RS03385	COG0642	Histidine kinase
HV239_RS03395	COG3111	PFAM Bacterial OB fold (BOF) protein
HV239_RS03400	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HV239_RS03405	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HV239_RS03410	COG0204	Acyl-transferase
HV239_RS03415	COG2132	Multicopper oxidase
HV239_RS03420	COG1032	radical SAM domain protein
HV239_RS03430	COG0656	L-ascorbic acid biosynthetic process
HV239_RS03435	COG1979	alcohol dehydrogenase
HV239_RS03440	COG2207	Transcriptional regulator
HV239_RS03445	COG0586	Pfam SNARE associated Golgi protein
HV239_RS03450	COG0626	cystathionine gamma-synthase activity
HV239_RS03460	COG0848	biopolymer transport protein
HV239_RS03465	COG2211	Major facilitator Superfamily
HV239_RS03490	COG0625	glutathione transferase activity
HV239_RS03505	COG0754	glutathionylspermidine amidase activity
HV239_RS03510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV239_RS03530	COG0583	DNA-binding transcription factor activity
HV239_RS03535	COG0626	cystathionine gamma-synthase activity
HV239_RS03550	COG1811	Na channel or pump
HV239_RS03555	COG1982	Orn Lys Arg decarboxylase major
HV239_RS03560	COG2211	Major facilitator Superfamily
HV239_RS03575	COG1194	a g-specific adenine glycosylase
HV239_RS03585	COG3171	Protein conserved in bacteria
HV239_RS03595	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HV239_RS03610	COG0762	integral membrane protein
HV239_RS03615	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HV239_RS03620	COG2805	Type II/IV secretion system protein
HV239_RS03640	COG0189	ligase activity
HV239_RS03645	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HV239_RS03650	COG2356	endonuclease I
HV239_RS03660	COG2814	Major facilitator Superfamily
HV239_RS03695	COG0501	Belongs to the peptidase M48B family
HV239_RS03700	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV239_RS03715	COG0191	fructose-bisphosphate aldolase activity
HV239_RS03720	COG0668	transmembrane transport
HV239_RS03730	COG2968	Membrane
HV239_RS03745	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV239_RS03750	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HV239_RS03770	COG0006	proline dipeptidase activity
HV239_RS03775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV239_RS03780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV239_RS03800	COG1028	Short-chain dehydrogenase reductase Sdr
HV239_RS03810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HV239_RS03830	COG2723	6-phospho-beta-galactosidase activity
HV239_RS03835	COG1737	Transcriptional regulator
HV239_RS03845	COG1272	protein, Hemolysin III
HV239_RS03855	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HV239_RS03865	COG0716	FMN binding
HV239_RS03870	COG4974	Belongs to the 'phage' integrase family
HV239_RS03880	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HV239_RS03900	COG4942	peptidase
HV239_RS03910	COG2814	Major facilitator Superfamily
HV239_RS03980	COG0667	Aldo Keto reductase
HV239_RS03985	COG0814	amino acid
HV239_RS04000	COG0183	Belongs to the thiolase family
HV239_RS04010	COG0823	Involved in the tonB-independent uptake of proteins
HV239_RS04015	COG1028	Short-chain dehydrogenase reductase Sdr
HV239_RS04020	COG2814	Major facilitator Superfamily
HV239_RS04055	COG3842	ATPase activity
HV239_RS04060	COG0395	ABC-type sugar transport system, permease component
HV239_RS04065	COG1175	transmembrane transport
HV239_RS04070	COG1917	Cupin 2, conserved barrel domain protein
HV239_RS04075	COG1794	racemase activity, acting on amino acids and derivatives
HV239_RS04080	COG0583	DNA-binding transcription factor activity
HV239_RS04090	COG1609	Transcriptional regulator
HV239_RS04095	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV239_RS04100	COG2723	6-phospho-beta-galactosidase activity
HV239_RS04105	COG2186	Transcriptional regulator
HV239_RS04115	COG1609	Transcriptional regulator
HV239_RS04130	COG0667	Aldo Keto reductase
HV239_RS04140	COG0861	Integral membrane protein TerC family
HV239_RS04175	COG2165	general secretion pathway protein
HV239_RS04180	COG4795	General secretion pathway protein
HV239_RS04190	COG4967	type IV pilus modification protein PilV
HV239_RS04195	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HV239_RS04200	COG1025	Belongs to the peptidase M16 family
HV239_RS04205	COG1074	ATP-dependent DNA helicase activity
HV239_RS04210	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HV239_RS04220	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HV239_RS04220	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HV239_RS04225	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV239_RS04230	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HV239_RS04260	COG4656	Part of a membrane complex involved in electron transport
HV239_RS04265	COG1012	belongs to the aldehyde dehydrogenase family
HV239_RS04265	COG1454	alcohol dehydrogenase
HV239_RS04500	COG2885	chlorophyll binding
HV239_RS04535	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HV239_RS04540	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HV239_RS04545	COG2166	iron-sulfur cluster assembly
HV239_RS04550	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HV239_RS04560	COG0583	DNA-binding transcription factor activity
HV239_RS04565	COG2363	Small membrane protein
HV239_RS04575	COG1349	DNA-binding transcription factor activity
HV239_RS04595	COG0738	Major facilitator superfamily
HV239_RS04600	COG0235	Class ii aldolase
HV239_RS04605	COG1454	alcohol dehydrogenase
HV239_RS04625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV239_RS04640	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HV239_RS04645	COG2011	ABC-type metal ion transport system permease component
HV239_RS04650	COG1464	Belongs to the NlpA lipoprotein family
HV239_RS04655	COG0477	Major facilitator Superfamily
HV239_RS04670	COG1760	l-serine dehydratase
HV239_RS04675	COG0814	amino acid
HV239_RS04680	COG1611	Belongs to the LOG family
HV239_RS04695	COG3098	single-species biofilm formation
HV239_RS04700	COG0564	pseudouridine synthase activity
HV239_RS04705	COG0716	FMN binding
HV239_RS04710	COG2271	Major facilitator Superfamily
HV239_RS04715	COG4948	Mandelate Racemase Muconate Lactonizing
HV239_RS04720	COG4948	Mandelate Racemase Muconate Lactonizing
HV239_RS04725	COG1929	Belongs to the glycerate kinase type-1 family
HV239_RS04730	COG3850	Histidine kinase
HV239_RS04730	COG4999	Histidine kinase
HV239_RS04730	COG3437	response regulator, receiver
HV239_RS04730	COG2205	protein histidine kinase activity
HV239_RS04740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV239_RS04745	COG3956	TIGRFAM MazG family protein
HV239_RS04765	COG0602	queuosine metabolic process
HV239_RS04770	COG0720	synthase
HV239_RS04790	COG2234	aminopeptidase activity
HV239_RS04850	COG1388	LysM domain
HV239_RS04850	COG4942	peptidase
HV239_RS04855	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HV239_RS04880	COG0163	prenyltransferase activity
HV239_RS04885	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HV239_RS04910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV239_RS04915	COG4558	Periplasmic binding protein
HV239_RS04920	COG3720	iron ion transport
HV239_RS04940	COG0679	Auxin Efflux Carrier
HV239_RS04955	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV239_RS04960	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV239_RS04965	COG1121	(ABC) transporter
HV239_RS04975	COG1609	Transcriptional regulator
HV239_RS04980	COG1940	carbohydrate kinase activity
HV239_RS04985	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV239_RS04990	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV239_RS04995	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV239_RS05000	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV239_RS05005	COG4580	involved in the transport of maltose and maltodextrins
HV239_RS05015	COG2723	6-phospho-beta-galactosidase activity
HV239_RS05025	COG0309	Hydrogenase expression formation protein (HypE)
HV239_RS05030	COG0409	Hydrogenase expression formation protein
HV239_RS05035	COG0298	carbon dioxide binding
HV239_RS05040	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HV239_RS05055	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV239_RS05060	COG0651	ATP synthesis coupled electron transport
HV239_RS05065	COG0650	Formate hydrogenlyase subunit 4
HV239_RS05070	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HV239_RS05070	COG3261	NADH dehydrogenase
HV239_RS05075	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV239_RS05080	COG3260	NADH ubiquinone oxidoreductase 20
HV239_RS05090	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HV239_RS05100	COG2723	6-phospho-beta-galactosidase activity
HV239_RS05105	COG1263	PTS System
HV239_RS05105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV239_RS05110	COG1609	Transcriptional regulator
HV239_RS05115	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV239_RS05120	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HV239_RS05125	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HV239_RS05150	COG1349	DNA-binding transcription factor activity
HV239_RS05155	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV239_RS05160	COG1028	Short-chain dehydrogenase reductase Sdr
HV239_RS05170	COG3732	PTS system glucitol sorbitol-specific
HV239_RS05175	COG3730	PTS system glucitol sorbitol-specific
HV239_RS05180	COG2951	lytic endotransglycosylase activity
HV239_RS05185	COG1121	(ABC) transporter
HV239_RS05190	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV239_RS05195	COG0803	Belongs to the bacterial solute-binding protein 9 family
HV239_RS05200	COG1546	Belongs to the CinA family
HV239_RS05220	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HV239_RS05250	COG2823	Periplasmic or secreted lipoprotein
HV239_RS05255	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV239_RS05260	COG1238	metal cluster binding
HV239_RS05280	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HV239_RS05285	COG2814	Major facilitator Superfamily
HV239_RS05290	COG1566	PFAM secretion protein HlyD family protein
HV239_RS05295	COG1846	Transcriptional regulator
HV239_RS05305	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HV239_RS05315	COG4176	ABC-type proline glycine betaine transport system permease component
HV239_RS05330	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HV239_RS05340	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HV239_RS05345	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV239_RS05350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV239_RS05355	COG4575	ribosome binding
HV239_RS05370	COG2916	Histone family protein nucleoid-structuring protein H-NS
HV239_RS05385	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV239_RS05390	COG0640	Transcriptional regulator
HV239_RS05400	COG0583	DNA-binding transcription factor activity
HV239_RS05405	COG3284	Transcriptional regulator
HV239_RS05410	COG1012	belongs to the aldehyde dehydrogenase family
HV239_RS05415	COG3539	Fimbrial protein
HV239_RS05420	COG3121	Chaperone
HV239_RS05460	COG3539	Fimbrial protein
HV239_RS05465	COG2197	response regulator
HV239_RS05480	COG1028	Short-chain dehydrogenase reductase Sdr
HV239_RS05490	COG0235	Class ii aldolase
HV239_RS05500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV239_RS05535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV239_RS05540	COG3708	Transcriptional regulator
HV239_RS05540	COG2207	Transcriptional regulator
HV239_RS05620	COG0582	viral genome integration into host DNA
HV239_RS05635	COG2867	negative regulation of translational initiation
HV239_RS05650	COG0497	DNA recombination
HV239_RS05665	COG4536	flavin adenine dinucleotide binding
HV239_RS05670	COG4137	Cytochrome C assembly protein
HV239_RS05675	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HV239_RS05710	COG2885	chlorophyll binding
HV239_RS05715	COG2199	diguanylate cyclase activity
HV239_RS05725	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV239_RS05730	COG0287	Prephenate dehydrogenase
HV239_RS05730	COG1605	Chorismate mutase
HV239_RS05740	COG0077	Prephenate dehydratase
HV239_RS05740	COG1605	Chorismate mutase
HV239_RS05750	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HV239_RS05755	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV239_RS05770	COG0542	response to heat
HV239_RS05795	COG0477	Major facilitator Superfamily
HV239_RS05800	COG5544	Lipoprotein
HV239_RS05805	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV239_RS05820	COG3118	belongs to the thioredoxin family
HV239_RS05825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV239_RS05840	COG0513	Belongs to the DEAD box helicase family
HV239_RS05850	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HV239_RS05865	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HV239_RS05870	COG3026	antisigma factor binding
HV239_RS05875	COG3086	response to oxidative stress
HV239_RS05885	COG0681	Belongs to the peptidase S26 family
HV239_RS05905	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HV239_RS05915	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV239_RS05920	COG1737	Transcriptional regulator
HV239_RS05925	COG0560	Phosphoserine phosphatase
HV239_RS05940	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HV239_RS05940	COG0047	phosphoribosylformylglycinamidine synthase activity
HV239_RS05945	COG2205	protein histidine kinase activity
HV239_RS05950	COG3170	Tfp pilus assembly protein FimV
HV239_RS05955	COG2204	response regulator
HV239_RS05960	COG0347	Belongs to the P(II) protein family
HV239_RS05965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV239_RS05965	COG1017	nitric oxide dioxygenase activity
HV239_RS05975	COG2259	Doxx family
HV239_RS05980	COG1940	carbohydrate kinase activity
HV239_RS05985	COG0457	Tetratricopeptide repeat
HV239_RS05990	COG2814	Major facilitator Superfamily
HV239_RS05990	COG0477	Major facilitator Superfamily
HV239_RS05995	COG2017	converts alpha-aldose to the beta-anomer
HV239_RS06000	COG2814	Major facilitator Superfamily
HV239_RS06005	COG3711	transcriptional antiterminator
HV239_RS06010	COG3683	transport system, periplasmic component
HV239_RS06015	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HV239_RS06045	COG0822	iron-sulfur transferase activity
HV239_RS06065	COG0633	Ferredoxin
HV239_RS06070	COG2975	iron-sulfur cluster assembly
HV239_RS06090	COG2897	thiosulfate sulfurtransferase activity
HV239_RS06095	COG2373	Large extracellular alpha-helical protein
HV239_RS06100	COG4953	penicillin-binding protein 1C
HV239_RS06130	COG2976	Protein conserved in bacteria
HV239_RS06160	COG1645	bacterial-type flagellum-dependent swarming motility
HV239_RS06170	COG0517	IMP dehydrogenase activity
HV239_RS06170	COG0516	GMP reductase activity
HV239_RS06180	COG3119	arylsulfatase activity
HV239_RS06185	COG0641	radical SAM
HV239_RS06220	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HV239_RS06235	COG2723	6-phospho-beta-galactosidase activity
HV239_RS06245	COG2233	PERMEase
HV239_RS06260	COG1393	Belongs to the ArsC family
HV239_RS06265	COG4783	chaperone-mediated protein folding
HV239_RS06275	COG0628	permease
HV239_RS06280	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HV239_RS06285	COG2716	regulation of RNA biosynthetic process
HV239_RS06295	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HV239_RS06305	COG2321	neutral zinc metallopeptidase
HV239_RS06310	COG1444	tRNA N-acetyltransferase activity
HV239_RS06315	COG0400	carboxylic ester hydrolase activity
HV239_RS06330	COG1393	Belongs to the ArsC family
HV239_RS06340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV239_RS06345	COG0493	'glutamate synthase
HV239_RS06345	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV239_RS06355	COG5342	invasion associated locus B
HV239_RS06360	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV239_RS06365	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HV239_RS06375	COG4810	utilization protein
HV239_RS06475	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV239_RS06495	COG2837	iron assimilation
HV239_RS06505	COG4150	thiosulfate binding
HV239_RS06510	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HV239_RS06515	COG4208	sulfate ABC transporter
HV239_RS06520	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HV239_RS06530	COG4319	ketosteroid isomerase
HV239_RS06565	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HV239_RS06585	COG3530	Putative quorum-sensing-regulated virulence factor
HV239_RS06590	COG0385	Bile acid
HV239_RS06595	COG0583	DNA-binding transcription factor activity
HV239_RS06625	COG3415	Transposase
HV239_RS06630	COG3415	Transposase
HV239_RS06645	COG2200	EAL domain
HV239_RS06645	COG2199	diguanylate cyclase activity
HV239_RS06650	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV239_RS06665	COG0667	Aldo Keto reductase
HV239_RS06670	COG3961	Belongs to the TPP enzyme family
HV239_RS06685	COG3279	Response regulator of the LytR AlgR family
HV239_RS06690	COG3275	phosphorelay sensor kinase activity
HV239_RS06705	COG0436	Aminotransferase
HV239_RS06715	COG2807	transmembrane transport
HV239_RS06720	COG0590	tRNA wobble adenosine to inosine editing
HV239_RS06725	COG0583	DNA-binding transcription factor activity
HV239_RS06745	COG2116	formate transmembrane transporter activity
HV239_RS06750	COG2853	Lipoprotein
HV239_RS06760	COG3691	Protein conserved in bacteria
HV239_RS06775	COG2062	phosphohistidine phosphatase, SixA
HV239_RS06800	COG0730	response to heat
HV239_RS06805	COG3101	peptidyl-lysine hydroxylation
HV239_RS06820	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV239_RS06840	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HV239_RS06850	COG0586	Pfam SNARE associated Golgi protein
HV239_RS06860	COG0285	dihydrofolate synthase activity
HV239_RS06865	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HV239_RS06870	COG1286	toxin biosynthetic process
HV239_RS06875	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HV239_RS06880	COG0163	prenyltransferase activity
HV239_RS06905	COG4160	amino acid transport
HV239_RS06910	COG4598	ABC transporter
HV239_RS06925	COG1090	epimerase
HV239_RS06930	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HV239_RS06935	COG0625	glutathione transferase activity
HV239_RS06940	COG0625	glutathione transferase activity
HV239_RS06945	COG0622	Phosphoesterase
HV239_RS06950	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HV239_RS06955	COG0857	belongs to the CobB CobQ family
HV239_RS06955	COG0280	phosphate acetyltransferase
HV239_RS06975	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV239_RS06980	COG0490	domain, Protein
HV239_RS06980	COG0471	metal ion transport
HV239_RS06990	COG0436	Aminotransferase
HV239_RS06995	COG0583	DNA-binding transcription factor activity
HV239_RS07040	COG0839	Belongs to the complex I subunit 6 family
HV239_RS07050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HV239_RS07055	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV239_RS07070	COG2153	protein acetylation
HV239_RS07075	COG1169	isochorismate synthase
HV239_RS07100	COG0318	PFAM AMP-dependent synthetase and ligase
HV239_RS07110	COG5464	transposase or invertase
HV239_RS07125	COG1414	Transcriptional regulator
HV239_RS07135	COG2271	Major facilitator Superfamily
HV239_RS07145	COG0247	lactate metabolic process
HV239_RS07155	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HV239_RS07160	COG2271	Major facilitator Superfamily
HV239_RS07165	COG0584	glycerophosphoryl diester phosphodiesterase
HV239_RS07170	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV239_RS07195	COG2205	protein histidine kinase activity
HV239_RS07195	COG0784	Response regulator, receiver
HV239_RS07205	COG2198	Histidine kinase
HV239_RS07205	COG0642	Histidine kinase
HV239_RS07225	COG3145	DNA-N1-methyladenine dioxygenase activity
HV239_RS07230	COG4615	Cyclic peptide transporter
HV239_RS07235	COG2239	Acts as a magnesium transporter
HV239_RS07240	COG0659	secondary active sulfate transmembrane transporter activity
HV239_RS07255	COG0628	permease
HV239_RS07280	COG1349	DNA-binding transcription factor activity
HV239_RS07285	COG0494	nUDIX hydrolase
HV239_RS07305	COG1061	Type III restriction enzyme res subunit
HV239_RS07310	COG1187	pseudouridine synthase activity
HV239_RS07315	COG2814	Major facilitator Superfamily
HV239_RS07325	COG4172	Belongs to the ABC transporter superfamily
HV239_RS07330	COG4239	(ABC) transporter, permease
HV239_RS07335	COG4174	ABC transporter (Permease)
HV239_RS07340	COG4166	transmembrane transport
HV239_RS07345	COG2200	EAL domain
HV239_RS07350	COG0791	NLP P60 protein
HV239_RS07355	COG0671	phosphoesterase, PA-phosphatase related
HV239_RS07360	COG0523	cobalamin synthesis protein
HV239_RS07365	COG0246	Mannitol dehydrogenase
HV239_RS07370	COG1312	Catalyzes the dehydration of D-mannonate
HV239_RS07390	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV239_RS07390	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV239_RS07395	COG1105	Belongs to the carbohydrate kinase PfkB family
HV239_RS07400	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HV239_RS07400	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV239_RS07400	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV239_RS07410	COG2855	membrane
HV239_RS07415	COG0583	DNA-binding transcription factor activity
HV239_RS07420	COG0833	amino acid
HV239_RS07440	COG2311	Membrane
HV239_RS07455	COG1129	ABC transporter
HV239_RS07465	COG2949	membrane
HV239_RS07475	COG1346	cytolysis
HV239_RS07485	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HV239_RS07490	COG3659	wide pore channel activity
HV239_RS07505	COG2723	6-phospho-beta-galactosidase activity
HV239_RS07510	COG1538	Outer membrane efflux protein
HV239_RS07515	COG0586	Pfam SNARE associated Golgi protein
HV239_RS07525	COG1686	Belongs to the peptidase S11 family
HV239_RS07535	COG0277	FAD linked oxidase domain protein
HV239_RS07540	COG1472	Belongs to the glycosyl hydrolase 3 family
HV239_RS07545	COG1732	Glycine betaine
HV239_RS07550	COG1174	glycine betaine transport
HV239_RS07555	COG1125	glycine betaine transport
HV239_RS07560	COG1174	glycine betaine transport
HV239_RS07570	COG3275	phosphorelay sensor kinase activity
HV239_RS07580	COG4807	Protein conserved in bacteria
HV239_RS07600	COG5455	response to cobalt ion
HV239_RS07605	COG0583	DNA-binding transcription factor activity
HV239_RS07610	COG2252	PERMEase
HV239_RS07620	COG0583	DNA-binding transcription factor activity
HV239_RS07635	COG0351	phosphomethylpyrimidine kinase
HV239_RS07640	COG2188	Transcriptional regulator
HV239_RS07645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV239_RS07650	COG1397	ADP-ribosylglycohydrolase
HV239_RS07655	COG2211	Major facilitator Superfamily
HV239_RS07660	COG1830	Aldolase
HV239_RS07680	COG0745	RESPONSE REGULATOR receiver
HV239_RS07685	COG2205	protein histidine kinase activity
HV239_RS07710	COG1301	dicarboxylic acid transport
HV239_RS07730	COG5002	protein histidine kinase activity
HV239_RS07735	COG0443	Heat shock 70 kDa protein
HV239_RS07740	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HV239_RS07755	COG2982	Protein involved in outer membrane biogenesis
HV239_RS07760	COG1253	flavin adenine dinucleotide binding
HV239_RS07800	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HV239_RS07800	COG1215	transferase activity, transferring glycosyl groups
HV239_RS07820	COG0438	transferase activity, transferring glycosyl groups
HV239_RS07825	COG0438	transferase activity, transferring glycosyl groups
HV239_RS07900	COG0438	transferase activity, transferring glycosyl groups
HV239_RS07905	COG1216	Glycosyl transferase, family 2
HV239_RS07905	COG1442	glycosyl transferase family 8
HV239_RS07915	COG0463	Glycosyl transferase, family 2
HV239_RS07940	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HV239_RS07970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV239_RS07975	COG0583	DNA-binding transcription factor activity
HV239_RS07985	COG0531	amino acid
HV239_RS07995	COG0640	Transcriptional regulator
HV239_RS08000	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HV239_RS08005	COG2925	Exonuclease
HV239_RS08020	COG1289	transmembrane transporter activity
HV239_RS08040	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HV239_RS08050	COG1942	4-Oxalocrotonate Tautomerase
HV239_RS08055	COG0583	DNA-binding transcription factor activity
HV239_RS08060	COG0095	Lipoate-protein ligase
HV239_RS08065	COG0477	Major facilitator Superfamily
HV239_RS08075	COG5001	Diguanylate cyclase
HV239_RS08075	COG3300	MHYT domain
HV239_RS08085	COG3615	Tellurite resistance protein tehB
HV239_RS08110	COG3706	GGDEF domain
HV239_RS08125	COG0534	Mate efflux family protein
HV239_RS08135	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HV239_RS08155	COG0604	alcohol dehydrogenase
HV239_RS08160	COG1309	transcriptional regulator
HV239_RS08165	COG0025	NhaP-type Na H and K H
HV239_RS08175	COG3311	Transcriptional regulator
HV239_RS08315	COG0582	viral genome integration into host DNA
HV239_RS08365	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV239_RS08375	COG1418	mRNA catabolic process
HV239_RS08380	COG0270	DNA (cytosine-5-)-methyltransferase activity
HV239_RS08385	COG3727	T/G mismatch-specific endonuclease activity
HV239_RS08390	COG0697	spore germination
HV239_RS08395	COG2354	Protein conserved in bacteria
HV239_RS08425	COG0366	Alpha amylase catalytic
HV239_RS08450	COG2197	response regulator
HV239_RS08460	COG2197	response regulator
HV239_RS08495	COG3318	Belongs to the UPF0149 family
HV239_RS08495	COG3012	SEC-C Motif Domain Protein
HV239_RS08500	COG0814	amino acid
HV239_RS08510	COG1528	Iron-storage protein
HV239_RS08525	COG0477	Major facilitator Superfamily
HV239_RS08535	COG2211	Major facilitator Superfamily
HV239_RS08545	COG1528	Iron-storage protein
HV239_RS08555	COG1879	ABC-type sugar transport system periplasmic component
HV239_RS08565	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV239_RS08590	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HV239_RS08600	COG3102	Protein conserved in bacteria
HV239_RS08620	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HV239_RS08625	COG1801	Protein of unknown function DUF72
HV239_RS08630	COG1335	isochorismatase
HV239_RS08640	COG0494	nUDIX hydrolase
HV239_RS08665	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV239_RS08675	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HV239_RS08680	COG0739	heme binding
HV239_RS08685	COG1560	Kdo2-lipid A biosynthetic process
HV239_RS08695	COG1737	Transcriptional regulator
HV239_RS08705	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HV239_RS08710	COG0129	dihydroxy-acid dehydratase activity
HV239_RS08715	COG0800	Aldolase
HV239_RS08725	COG3141	response to X-ray
HV239_RS08730	COG2979	Protein of unknown function (DUF533)
HV239_RS08735	COG1770	oligopeptidase
HV239_RS08740	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV239_RS08750	COG2372	response to copper ion
HV239_RS08755	COG1276	copper resistance
HV239_RS08770	COG2990	Protein conserved in bacteria
HV239_RS08795	COG3008	intermembrane lipid transfer
HV239_RS08800	COG2995	paraquat-inducible protein a
HV239_RS08805	COG1956	GAF domain-containing protein
HV239_RS08825	COG2814	Major facilitator Superfamily
HV239_RS08830	COG1414	Transcriptional regulator
HV239_RS08855	COG3039	Transposase
HV239_RS08865	COG0768	penicillin binding
HV239_RS08870	COG2226	methyltransferase
HV239_RS08885	COG3716	PTS system mannose fructose sorbose family IID component
HV239_RS08890	COG3715	PTS system
HV239_RS08895	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV239_RS08895	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV239_RS08900	COG1253	flavin adenine dinucleotide binding
HV239_RS08905	COG2200	EAL domain
HV239_RS08910	COG1760	l-serine dehydratase
HV239_RS08930	COG0251	oxidation-reduction process
HV239_RS08935	COG1199	ATP-dependent helicase activity
HV239_RS08945	COG3065	identical protein binding
HV239_RS08955	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HV239_RS08965	COG2894	cell division
HV239_RS08980	COG0179	Fumarylacetoacetate (FAA) hydrolase
HV239_RS09010	COG2719	SpoVR family
HV239_RS09035	COG1619	proteins homologs of microcin C7 resistance protein MccF
HV239_RS09045	COG4774	siderophore transport
HV239_RS09060	COG2308	Evidence 4 Homologs of previously reported genes of
HV239_RS09100	COG0583	DNA-binding transcription factor activity
HV239_RS09105	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HV239_RS09155	COG0583	DNA-binding transcription factor activity
HV239_RS09185	COG0583	DNA-binding transcription factor activity
HV239_RS09195	COG0564	pseudouridine synthase activity
HV239_RS09200	COG3122	Protein conserved in bacteria
HV239_RS09210	COG3039	Transposase
HV239_RS09225	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HV239_RS09255	COG3039	Transposase
HV239_RS09320	COG0012	GTP binding
HV239_RS09340	COG0659	secondary active sulfate transmembrane transporter activity
HV239_RS09370	COG2890	protein-(glutamine-N5) methyltransferase activity
HV239_RS09390	COG0387	Pfam Sodium calcium exchanger
HV239_RS09395	COG4572	Cation transport regulator
HV239_RS09400	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HV239_RS09410	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HV239_RS09415	COG3707	response regulator
HV239_RS09420	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HV239_RS09430	COG1116	anion transmembrane transporter activity
HV239_RS09435	COG2146	nitrite reductase [NAD(P)H] activity
HV239_RS09435	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HV239_RS09440	COG0243	molybdopterin cofactor binding
HV239_RS09445	COG4932	domain protein
HV239_RS09450	COG2197	response regulator
HV239_RS09455	COG3850	Histidine kinase
HV239_RS09460	COG2223	nitrite transmembrane transporter activity
HV239_RS09470	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HV239_RS09475	COG1140	nitrate reductase beta subunit
HV239_RS09480	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HV239_RS09485	COG2181	nitrate reductase activity
HV239_RS09495	COG1522	sequence-specific DNA binding
HV239_RS09535	COG0788	formyltetrahydrofolate deformylase activity
HV239_RS09545	COG1752	Esterase of the alpha-beta hydrolase superfamily
HV239_RS09550	COG0745	RESPONSE REGULATOR receiver
HV239_RS09555	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HV239_RS09560	COG2916	Histone family protein nucleoid-structuring protein H-NS
HV239_RS09570	COG1435	thymidine kinase activity
HV239_RS09575	COG1012	belongs to the aldehyde dehydrogenase family
HV239_RS09575	COG1454	alcohol dehydrogenase
HV239_RS09585	COG2095	MarC family integral membrane protein
HV239_RS09590	COG4166	transmembrane transport
HV239_RS09595	COG0601	transmembrane transport
HV239_RS09600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV239_RS09605	COG0444	Belongs to the ABC transporter superfamily
HV239_RS09615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV239_RS09635	COG3039	Transposase
HV239_RS09640	COG2353	YceI-like domain
HV239_RS09650	COG2350	Protein conserved in bacteria
HV239_RS09660	COG3001	Fructosamine kinase
HV239_RS09670	COG1105	Belongs to the carbohydrate kinase PfkB family
HV239_RS09675	COG3137	Salt-induced outer membrane protein
HV239_RS09715	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HV239_RS09715	COG0072	phenylalanine-tRNA ligase activity
HV239_RS09735	COG0583	DNA-binding transcription factor activity
HV239_RS09755	COG0386	Belongs to the glutathione peroxidase family
HV239_RS09765	COG0791	NLP P60 protein
HV239_RS09775	COG4256	Hemin uptake protein
HV239_RS09780	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV239_RS09795	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HV239_RS09795	COG0574	Belongs to the PEP-utilizing enzyme family
HV239_RS09805	COG0628	permease
HV239_RS09810	COG0277	FAD linked oxidase domain protein
HV239_RS09810	COG0247	lactate metabolic process
HV239_RS09815	COG2050	protein possibly involved in aromatic compounds catabolism
HV239_RS09820	COG2261	transglycosylase associated protein
HV239_RS09845	COG1120	ATPase activity
HV239_RS09850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV239_RS09860	COG0583	DNA-binding transcription factor activity
HV239_RS09885	COG1304	FMN binding
HV239_RS09890	COG1309	transcriptional regulator
HV239_RS09910	COG0316	Belongs to the HesB IscA family
HV239_RS09915	COG0719	Fe-S assembly protein
HV239_RS09920	COG0396	ATPase activity
HV239_RS09925	COG0719	Fe-S assembly protein
HV239_RS09940	COG1376	ErfK ybiS ycfS ynhG family protein
HV239_RS09970	COG1309	transcriptional regulator
HV239_RS09980	COG2271	Major facilitator Superfamily
HV239_RS09985	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HV239_RS10010	COG1414	Transcriptional regulator
HV239_RS10045	COG2814	Major facilitator Superfamily
HV239_RS10065	COG0583	DNA-binding transcription factor activity
HV239_RS10070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV239_RS10090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV239_RS10095	COG1116	anion transmembrane transporter activity
HV239_RS10100	COG4774	siderophore transport
HV239_RS10105	COG1120	ATPase activity
HV239_RS10110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV239_RS10115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV239_RS10135	COG0765	amino acid transport
HV239_RS10180	COG3383	formate dehydrogenase (NAD+) activity
HV239_RS10185	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HV239_RS10195	COG1175	transmembrane transport
HV239_RS10230	COG4133	protoheme IX ABC transporter activity
HV239_RS10235	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HV239_RS10240	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HV239_RS10255	COG1138	Cytochrome C-type biogenesis protein
HV239_RS10260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HV239_RS10265	COG3088	subunit of a heme lyase
HV239_RS10265	COG4235	cytochrome complex assembly
HV239_RS10305	COG1028	Short-chain dehydrogenase reductase Sdr
HV239_RS10310	COG2610	gluconate transmembrane transporter activity
HV239_RS10315	COG1250	3-hydroxyacyl-CoA dehydrogenase
HV239_RS10325	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HV239_RS10335	COG0583	DNA-binding transcription factor activity
HV239_RS10365	COG2814	Major facilitator Superfamily
HV239_RS10380	COG0277	FAD linked oxidase domain protein
HV239_RS10385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV239_RS10410	COG0402	S-adenosylhomocysteine deaminase activity
HV239_RS10465	COG4608	Belongs to the ABC transporter superfamily
HV239_RS10470	COG0444	Belongs to the ABC transporter superfamily
HV239_RS10495	COG0346	lactoylglutathione lyase activity
HV239_RS10500	COG1349	DNA-binding transcription factor activity
HV239_RS10535	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HV239_RS10545	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HV239_RS10665	COG4373	Mu-like prophage FluMu protein gp28
HV239_RS10675	COG0640	Transcriptional regulator
HV239_RS10690	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HV239_RS10740	COG3267	Type II secretory pathway component ExeA
HV239_RS10740	COG3409	Peptidoglycan-binding domain 1 protein
HV239_RS10835	COG0307	riboflavin synthase, alpha
HV239_RS10840	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HV239_RS10845	COG2814	Major facilitator Superfamily
HV239_RS10850	COG0583	DNA-binding transcription factor activity
HV239_RS10865	COG2814	Major facilitator Superfamily
HV239_RS10880	COG0791	NLP P60 protein
HV239_RS10885	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HV239_RS10895	COG0346	lactoylglutathione lyase activity
HV239_RS10900	COG1902	pentaerythritol trinitrate reductase activity
HV239_RS10905	COG1309	transcriptional regulator
HV239_RS10910	COG3313	Fe-S protein
HV239_RS10915	COG4989	oxidoreductase activity
HV239_RS10920	COG2032	superoxide dismutase activity
HV239_RS10925	COG1289	transmembrane transporter activity
HV239_RS10930	COG1566	PFAM secretion protein HlyD family protein
HV239_RS10945	COG3706	GGDEF domain
HV239_RS10960	COG3895	Periplasmic Protein
HV239_RS10975	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HV239_RS10980	COG0625	glutathione transferase activity
HV239_RS10990	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HV239_RS11000	COG4659	FMN binding
HV239_RS11035	COG2723	6-phospho-beta-galactosidase activity
HV239_RS11045	COG0673	inositol 2-dehydrogenase activity
HV239_RS11055	COG2814	Major facilitator Superfamily
HV239_RS11075	COG3038	cytochrome b561
HV239_RS11095	COG0583	DNA-binding transcription factor activity
HV239_RS11100	COG3485	protocatechuate 3,4-dioxygenase
HV239_RS11105	COG3485	protocatechuate 3,4-dioxygenase
HV239_RS11110	COG5383	Protein conserved in bacteria
HV239_RS11115	COG2272	Belongs to the type-B carboxylesterase lipase family
HV239_RS11130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV239_RS11135	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV239_RS11140	COG1275	C4-dicarboxylate transporter malic acid transport protein
HV239_RS11145	COG0500	methyltransferase
HV239_RS11155	COG0697	spore germination
HV239_RS11160	COG3708	Transcriptional regulator
HV239_RS11160	COG2207	Transcriptional regulator
HV239_RS11165	COG3135	benzoate transporter
HV239_RS11170	COG1396	sequence-specific DNA binding
HV239_RS11180	COG0826	peptidase U32
HV239_RS11200	COG1294	oxidase, subunit
HV239_RS11205	COG1271	oxidase subunit
HV239_RS11210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV239_RS11215	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HV239_RS11220	COG3842	ATPase activity
HV239_RS11225	COG1176	ABC-type spermidine putrescine transport system, permease component I
HV239_RS11230	COG1177	transmembrane transport
HV239_RS11235	COG1012	belongs to the aldehyde dehydrogenase family
HV239_RS11270	COG1012	belongs to the aldehyde dehydrogenase family
HV239_RS11275	COG0747	negative chemotaxis
HV239_RS11285	COG3238	Protein conserved in bacteria
HV239_RS11290	COG1247	-acetyltransferase
HV239_RS11300	COG2130	NADP-dependent
HV239_RS11315	COG3691	Protein conserved in bacteria
HV239_RS11320	COG1228	amidohydrolase
HV239_RS11325	COG4772	TonB-dependent receptor
HV239_RS11350	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HV239_RS11355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV239_RS11360	COG1473	amidohydrolase
HV239_RS11365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV239_RS11380	COG0765	amino acid transport
HV239_RS11385	COG1126	abc transporter atp-binding protein
HV239_RS11395	COG0625	glutathione transferase activity
HV239_RS11420	COG2211	Major facilitator Superfamily
HV239_RS11435	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HV239_RS11440	COG3842	ATPase activity
HV239_RS11445	COG1840	ABC-type Fe3 transport system, periplasmic component
HV239_RS11450	COG1178	ABC-type Fe3 transport system permease component
HV239_RS11455	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HV239_RS11460	COG2181	nitrate reductase activity
HV239_RS11465	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HV239_RS11470	COG1140	nitrate reductase beta subunit
HV239_RS11475	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HV239_RS11480	COG2223	nitrite transmembrane transporter activity
HV239_RS11495	COG1414	Transcriptional regulator
HV239_RS11500	COG4948	Mandelate Racemase Muconate Lactonizing
HV239_RS11505	COG4829	muconolactone delta-isomerase
HV239_RS11510	COG3485	protocatechuate 3,4-dioxygenase
HV239_RS11520	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HV239_RS11545	COG0437	4 iron, 4 sulfur cluster binding
HV239_RS11550	COG2864	formate dehydrogenase
HV239_RS11565	COG2326	polyphosphate kinase activity
HV239_RS11585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV239_RS11605	COG0747	negative chemotaxis
HV239_RS11610	COG1064	alcohol dehydrogenase
HV239_RS11625	COG0488	(ABC) transporter
HV239_RS11665	COG1028	Short-chain dehydrogenase reductase Sdr
HV239_RS11670	COG3729	General stress protein
HV239_RS11680	COG3685	Protein conserved in bacteria
HV239_RS11690	COG0366	Alpha amylase catalytic
HV239_RS11700	COG2323	membrane
HV239_RS11710	COG3111	PFAM Bacterial OB fold (BOF) protein
HV239_RS11720	COG1764	response to oxidative stress
HV239_RS11745	COG3781	membrane
HV239_RS11750	COG0243	molybdopterin cofactor binding
HV239_RS11755	COG0583	DNA-binding transcription factor activity
HV239_RS11760	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV239_RS11765	COG2814	Major facilitator Superfamily
HV239_RS11770	COG1285	pathogenesis
HV239_RS11775	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HV239_RS11795	COG0519	Catalyzes the synthesis of GMP from XMP
HV239_RS11795	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HV239_RS11835	COG0596	Alpha beta hydrolase
HV239_RS11840	COG0745	RESPONSE REGULATOR receiver
HV239_RS11845	COG2205	protein histidine kinase activity
HV239_RS11855	COG0583	DNA-binding transcription factor activity
HV239_RS11860	COG0076	glutamate decarboxylase activity
HV239_RS11865	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV239_RS11870	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HV239_RS11875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV239_RS11880	COG1116	anion transmembrane transporter activity
HV239_RS11885	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HV239_RS11900	COG0673	inositol 2-dehydrogenase activity
HV239_RS11910	COG1609	Transcriptional regulator
HV239_RS11915	COG3706	GGDEF domain
HV239_RS11920	COG0402	S-adenosylhomocysteine deaminase activity
HV239_RS11925	COG1953	Uracil, thiamine, allantoin
HV239_RS11965	COG0406	alpha-ribazole phosphatase activity
HV239_RS11980	COG2207	Transcriptional regulator
HV239_RS11995	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV239_RS12020	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HV239_RS12075	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HV239_RS12085	COG2070	2-Nitropropane dioxygenase
HV239_RS12090	COG0583	DNA-binding transcription factor activity
HV239_RS12100	COG1902	pentaerythritol trinitrate reductase activity
HV239_RS12105	COG4529	Protein conserved in bacteria
HV239_RS12110	COG0477	Major facilitator Superfamily
HV239_RS12140	COG2223	nitrite transmembrane transporter activity
HV239_RS12160	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HV239_RS12160	COG0456	acetyltransferase
HV239_RS12170	COG0667	Aldo Keto reductase
HV239_RS12175	COG0667	Aldo Keto reductase
HV239_RS12180	COG3386	PFAM SMP-30 Gluconolaconase
HV239_RS12185	COG0667	Aldo Keto reductase
HV239_RS12205	COG2801	Transposase and inactivated derivatives
HV239_RS12220	COG5002	protein histidine kinase activity
HV239_RS12220	COG3850	Histidine kinase
HV239_RS12255	COG2186	Transcriptional regulator
HV239_RS12260	COG1263	PTS System
HV239_RS12260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV239_RS12270	COG2814	Major facilitator Superfamily
HV239_RS12280	COG3039	Transposase
HV239_RS12285	COG3039	Transposase
HV239_RS12290	COG3039	Transposase
HV239_RS12310	COG2819	hydrolase of the alpha beta superfamily
HV239_RS12315	COG5001	Diguanylate cyclase
HV239_RS12315	COG3300	MHYT domain
HV239_RS12350	COG3188	usher protein
HV239_RS12365	COG3550	peptidyl-serine autophosphorylation
HV239_RS12370	COG1396	sequence-specific DNA binding
HV239_RS12375	COG2351	hydroxyisourate hydrolase activity
HV239_RS12380	COG3648	Uricase
HV239_RS12380	COG3195	allantoin biosynthetic process
HV239_RS12385	COG2233	PERMEase
HV239_RS12430	COG4628	conserved protein (DUF2132)
HV239_RS12450	COG2011	ABC-type metal ion transport system permease component
HV239_RS12455	COG2070	2-Nitropropane dioxygenase
HV239_RS12465	COG0477	Major facilitator Superfamily
HV239_RS12470	COG0346	lactoylglutathione lyase activity
HV239_RS12530	COG2199	diguanylate cyclase activity
HV239_RS12545	COG1012	belongs to the aldehyde dehydrogenase family
HV239_RS12550	COG0583	DNA-binding transcription factor activity
HV239_RS12560	COG0039	L-malate dehydrogenase activity
HV239_RS12565	COG1349	DNA-binding transcription factor activity
HV239_RS12570	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HV239_RS12575	COG3395	kinase activity
HV239_RS12585	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HV239_RS12590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV239_RS12595	COG2271	Major facilitator Superfamily
HV239_RS12625	COG4977	sequence-specific DNA binding
HV239_RS12635	COG0697	spore germination
HV239_RS12640	COG2814	Major facilitator Superfamily
HV239_RS12655	COG1129	ABC transporter
HV239_RS12670	COG0683	leucine binding
HV239_RS12675	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HV239_RS12710	COG2223	nitrite transmembrane transporter activity
HV239_RS12715	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HV239_RS12725	COG3039	Transposase
HV239_RS12730	COG3039	Transposase
HV239_RS12745	COG2135	peptidase activity
HV239_RS12750	COG2207	Transcriptional regulator
HV239_RS12765	COG4221	oxidoreductase activity
HV239_RS12770	COG1802	Transcriptional regulator
HV239_RS12775	COG0589	response to stress
HV239_RS12780	COG0246	Mannitol dehydrogenase
HV239_RS12785	COG2271	Major facilitator Superfamily
HV239_RS12800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV239_RS12820	COG0437	4 iron, 4 sulfur cluster binding
HV239_RS12825	COG3302	dmso reductase anchor subunit
HV239_RS12840	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HV239_RS12845	COG1940	carbohydrate kinase activity
HV239_RS12850	COG0583	DNA-binding transcription factor activity
HV239_RS12855	COG2814	Major facilitator Superfamily
HV239_RS12860	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HV239_RS12870	COG3591	Belongs to the peptidase S1B family
HV239_RS12890	COG0628	permease
HV239_RS12920	COG0679	Auxin Efflux Carrier
HV239_RS12930	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HV239_RS12955	COG3290	protein histidine kinase activity
HV239_RS12960	COG4565	transcriptional regulatory protein
HV239_RS12980	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV239_RS12980	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV239_RS12990	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV239_RS12995	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HV239_RS13005	COG0183	Belongs to the thiolase family
HV239_RS13010	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HV239_RS13020	COG1414	Transcriptional regulator
HV239_RS13025	COG2840	Smr protein MutS2
HV239_RS13030	COG0583	DNA-binding transcription factor activity
HV239_RS13040	COG1473	amidohydrolase
HV239_RS13045	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HV239_RS13075	COG3039	Transposase
HV239_RS13175	COG1802	Transcriptional regulator
HV239_RS13175	COG4626	Terminase
HV239_RS13205	COG3179	chitinase
HV239_RS13245	COG1061	Type III restriction enzyme res subunit
HV239_RS13260	COG4197	protein conserved in bacteria, prophage-related
HV239_RS13265	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HV239_RS13330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV239_RS13345	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HV239_RS13350	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HV239_RS13365	COG0531	amino acid
HV239_RS13375	COG3136	membrane protein required for alginate biosynthesis
HV239_RS13380	COG0745	RESPONSE REGULATOR receiver
HV239_RS13395	COG2205	protein histidine kinase activity
HV239_RS13405	COG0114	fumarate hydratase activity
HV239_RS13410	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV239_RS13410	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV239_RS13415	COG1482	cell wall glycoprotein biosynthetic process
HV239_RS13420	COG5339	Protein conserved in bacteria
HV239_RS13425	COG1609	Transcriptional regulator
HV239_RS13430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV239_RS13430	COG1263	PTS System
HV239_RS13435	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HV239_RS13460	COG2391	methyltransferase activity
HV239_RS13465	COG0425	Belongs to the sulfur carrier protein TusA family
HV239_RS13470	COG5562	phage envelope protein
HV239_RS13475	COG0401	homolog of Blt101
HV239_RS13480	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HV239_RS13485	COG1012	belongs to the aldehyde dehydrogenase family
HV239_RS13495	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HV239_RS13500	COG0477	Major facilitator Superfamily
HV239_RS13505	COG1113	amino acid transport
HV239_RS13510	COG2988	succinylglutamate desuccinylase activity
HV239_RS13520	COG1012	belongs to the aldehyde dehydrogenase family
HV239_RS13525	COG3138	arginine N-succinyltransferase
HV239_RS13530	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HV239_RS13540	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HV239_RS13545	COG0667	Aldo Keto reductase
HV239_RS13550	COG0583	DNA-binding transcription factor activity
HV239_RS13575	COG4122	O-methyltransferase activity
HV239_RS13580	COG1643	Atp-dependent helicase
HV239_RS13595	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV239_RS13600	COG3327	negative regulation of DNA-templated transcription, initiation
HV239_RS13605	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HV239_RS13610	COG0183	Belongs to the thiolase family
HV239_RS13615	COG2050	protein possibly involved in aromatic compounds catabolism
HV239_RS13620	COG1250	3-hydroxyacyl-CoA dehydrogenase
HV239_RS13625	COG1024	Enoyl-CoA hydratase
HV239_RS13630	COG1024	Enoyl-CoA hydratase
HV239_RS13635	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV239_RS13640	COG2151	metal-sulfur cluster biosynthetic enzyme
HV239_RS13645	COG3396	Phenylacetate-CoA oxygenase
HV239_RS13650	COG3460	Phenylacetate-CoA oxygenase
HV239_RS13655	COG3396	Phenylacetate-CoA oxygenase
HV239_RS13660	COG1012	belongs to the aldehyde dehydrogenase family
HV239_RS13660	COG2030	dehydratase
HV239_RS13680	COG1012	belongs to the aldehyde dehydrogenase family
HV239_RS13685	COG2207	Transcriptional regulator
HV239_RS13690	COG3784	Protein of unknown function (DUF1318)
HV239_RS13700	COG2911	Protein conserved in bacteria
HV239_RS13705	COG0586	Pfam SNARE associated Golgi protein
HV239_RS13710	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HV239_RS13715	COG3187	Heat shock protein
HV239_RS13720	COG3042	response to heat
HV239_RS13725	COG0674	pyruvate-flavodoxin oxidoreductase activity
HV239_RS13725	COG1013	pyruvate-flavodoxin oxidoreductase activity
HV239_RS13725	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV239_RS13725	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HV239_RS13730	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV239_RS13740	COG0589	response to stress
HV239_RS13750	COG0513	Belongs to the DEAD box helicase family
HV239_RS13760	COG1349	DNA-binding transcription factor activity
HV239_RS13765	COG0673	inositol 2-dehydrogenase activity
HV239_RS13780	COG3039	Transposase
HV239_RS13785	COG2011	ABC-type metal ion transport system permease component
HV239_RS13800	COG0436	Aminotransferase
HV239_RS13805	COG0604	alcohol dehydrogenase
HV239_RS13835	COG0583	DNA-binding transcription factor activity
HV239_RS13855	COG1028	Short-chain dehydrogenase reductase Sdr
HV239_RS13860	COG1309	transcriptional regulator
HV239_RS13865	COG1028	Short-chain dehydrogenase reductase Sdr
HV239_RS13930	COG3039	Transposase
HV239_RS13975	COG2885	chlorophyll binding
HV239_RS14110	COG4626	Terminase
HV239_RS14110	COG1802	Transcriptional regulator
HV239_RS14175	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HV239_RS14180	COG0305	Participates in initiation and elongation during chromosome replication
HV239_RS14185	COG1484	DNA-dependent DNA replication
HV239_RS14275	COG0582	viral genome integration into host DNA
HV239_RS14280	COG0693	protein deglycase activity
HV239_RS14285	COG1078	dGTPase activity
HV239_RS14290	COG1028	Short-chain dehydrogenase reductase Sdr
HV239_RS14295	COG0583	DNA-binding transcription factor activity
HV239_RS14310	COG0656	L-ascorbic acid biosynthetic process
HV239_RS14340	COG4166	transmembrane transport
HV239_RS14350	COG2866	Carboxypeptidase
HV239_RS14355	COG4948	Mandelate Racemase Muconate Lactonizing
HV239_RS14360	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HV239_RS14365	COG3180	Ammonia monooxygenase
HV239_RS14375	COG1486	melibiose metabolic process
HV239_RS14380	COG0583	DNA-binding transcription factor activity
HV239_RS14390	COG3106	COG3106 Predicted ATPase
HV239_RS14400	COG1983	PspC domain protein
HV239_RS14410	COG1842	Phage shock protein A
HV239_RS14415	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HV239_RS14425	COG1473	amidohydrolase
HV239_RS14440	COG0702	epimerase
HV239_RS14455	COG2135	peptidase activity
HV239_RS14465	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HV239_RS14470	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HV239_RS14515	COG2333	competence protein COMEC
HV239_RS14515	COG0658	competence protein
HV239_RS14540	COG1846	Transcriptional regulator
HV239_RS14595	COG4171	peptide transport system, permease
HV239_RS14610	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HV239_RS14620	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HV239_RS14625	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV239_RS14625	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV239_RS14640	COG1349	DNA-binding transcription factor activity
HV239_RS14650	COG0023	Translation Initiation Factor
HV239_RS14660	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HV239_RS14665	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HV239_RS14670	COG0671	phosphoesterase, PA-phosphatase related
HV239_RS14680	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HV239_RS14705	COG0616	signal peptide processing
HV239_RS14715	COG1028	Short-chain dehydrogenase reductase Sdr
HV239_RS14720	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HV239_RS14755	COG0583	DNA-binding transcription factor activity
HV239_RS14765	COG0009	L-threonylcarbamoyladenylate synthase
HV239_RS14775	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HV239_RS14780	COG0512	Glutamine amidotransferase of anthranilate synthase
HV239_RS14780	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HV239_RS14785	COG0135	phosphoribosylanthranilate isomerase activity
HV239_RS14785	COG0134	indole-3-glycerol-phosphate synthase activity
HV239_RS14820	COG4774	siderophore transport
HV239_RS14830	COG3047	cAMP biosynthetic process
HV239_RS14835	COG0727	PFAM Uncharacterised protein family (UPF0153)
HV239_RS14865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV239_RS14870	COG1028	Short-chain dehydrogenase reductase Sdr
HV239_RS14875	COG1988	membrane-bound metal-dependent
HV239_RS14890	COG0753	catalase activity
HV239_RS14900	COG1486	melibiose metabolic process
HV239_RS14905	COG1917	Cupin 2, conserved barrel domain protein
HV239_RS14905	COG2169	Transcriptional regulator
HV239_RS14910	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV239_RS14915	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV239_RS14925	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV239_RS14930	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV239_RS14940	COG0322	excinuclease ABC activity
HV239_RS14945	COG3678	ATP-independent chaperone mediated protein folding
HV239_RS14955	COG3724	N-succinylarginine dihydrolase activity
HV239_RS14965	COG3138	arginine N-succinyltransferase
HV239_RS14975	COG0708	Exodeoxyribonuclease III
HV239_RS14980	COG0398	Pfam SNARE associated Golgi protein
HV239_RS14985	COG0398	Pfam SNARE associated Golgi protein
HV239_RS14990	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV239_RS14995	COG4134	Bacterial extracellular solute-binding protein
HV239_RS15000	COG4135	transport system, permease component
HV239_RS15005	COG4136	ATPase activity
HV239_RS15010	COG2897	thiosulfate sulfurtransferase activity
HV239_RS15015	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HV239_RS15020	COG0494	nUDIX hydrolase
HV239_RS15025	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HV239_RS15030	COG3321	synthase
HV239_RS15030	COG0604	alcohol dehydrogenase
HV239_RS15030	COG1028	Short-chain dehydrogenase reductase Sdr
HV239_RS15035	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HV239_RS15040	COG0709	Synthesizes selenophosphate from selenide and ATP
HV239_RS15050	COG0778	Nitroreductase
HV239_RS15055	COG0616	signal peptide processing
HV239_RS15060	COG0252	asparaginase activity
HV239_RS15065	COG1335	isochorismatase
HV239_RS15080	COG3139	Protein of unknown function (DUF1315)
HV239_RS15100	COG0656	L-ascorbic acid biosynthetic process
HV239_RS15105	COG3713	MltA-interacting MipA family protein
HV239_RS15110	COG2766	serine protein kinase
HV239_RS15125	COG0386	Belongs to the glutathione peroxidase family
HV239_RS15150	COG1028	Short-chain dehydrogenase reductase Sdr
HV239_RS15155	COG0583	DNA-binding transcription factor activity
HV239_RS15165	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HV239_RS15175	COG0859	PFAM glycosyl transferase family 9
HV239_RS15180	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV239_RS15190	COG2207	Transcriptional regulator
HV239_RS15195	COG2807	transmembrane transport
HV239_RS15200	COG0504	CTP synthase activity
HV239_RS15205	COG1683	Conserved Protein
HV239_RS15210	COG3189	MarR family transcriptional regulator
HV239_RS15215	COG3042	response to heat
HV239_RS15220	COG2203	Gaf domain
HV239_RS15220	COG2199	diguanylate cyclase activity
HV239_RS15240	COG3182	Iron-regulated membrane protein
HV239_RS15250	COG1560	Kdo2-lipid A biosynthetic process
HV239_RS15260	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HV239_RS15265	COG3706	GGDEF domain
HV239_RS15270	COG0583	DNA-binding transcription factor activity
HV239_RS15275	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HV239_RS15305	COG1294	oxidase, subunit
HV239_RS15310	COG1271	oxidase subunit
HV239_RS15315	COG3546	catalase activity
HV239_RS15320	COG3685	Protein conserved in bacteria
HV239_RS15325	COG3685	Protein conserved in bacteria
HV239_RS15330	COG3729	General stress protein
HV239_RS15340	COG1063	alcohol dehydrogenase
HV239_RS15345	COG3813	Protein conserved in bacteria
HV239_RS15365	COG0640	Transcriptional regulator
HV239_RS15370	COG0538	isocitrate dehydrogenase activity
HV239_RS15460	COG0616	signal peptide processing
HV239_RS15475	COG1802	Transcriptional regulator
HV239_RS15475	COG4626	Terminase
HV239_RS15520	COG3772	lysozyme
HV239_RS15545	COG1403	HNH endonuclease
HV239_RS15550	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HV239_RS15565	COG3039	Transposase
HV239_RS15615	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV239_RS15625	COG0582	viral genome integration into host DNA
HV239_RS15640	COG0538	isocitrate dehydrogenase activity
HV239_RS15645	COG1187	pseudouridine synthase activity
HV239_RS15665	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HV239_RS15685	COG2205	protein histidine kinase activity
HV239_RS15690	COG2850	peptidyl-arginine hydroxylation
HV239_RS15710	COG1177	transmembrane transport
HV239_RS15725	COG0318	PFAM AMP-dependent synthetase and ligase
HV239_RS15730	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV239_RS15735	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HV239_RS15740	COG0698	ribose 5-phosphate isomerase
HV239_RS15755	COG3395	kinase activity
HV239_RS15770	COG2390	Transcriptional regulator
HV239_RS15780	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HV239_RS15790	COG4591	ABC-type transport system involved in lipoprotein release permease component
HV239_RS15800	COG4591	ABC-type transport system involved in lipoprotein release permease component
HV239_RS15810	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HV239_RS15815	COG1376	ErfK ybiS ycfS ynhG family protein
HV239_RS15815	COG1388	LysM domain
HV239_RS15830	COG1309	transcriptional regulator
HV239_RS15845	COG3134	Outer membrane lipoprotein
HV239_RS15850	COG1252	NADH dehydrogenase
HV239_RS15875	COG5633	Lipoprotein
HV239_RS15880	COG0537	adenosine 5'-monophosphoramidase activity
HV239_RS15890	COG0084	hydrolase, TatD family'
HV239_RS15895	COG0470	DNA polymerase III
HV239_RS15905	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HV239_RS15910	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HV239_RS15915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV239_RS15930	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HV239_RS15950	COG1399	metal-binding, possibly nucleic acid-binding protein
HV239_RS15970	COG1530	ribonuclease E activity
HV239_RS15975	COG0583	DNA-binding transcription factor activity
HV239_RS15980	COG2814	Major facilitator Superfamily
HV239_RS16000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV239_RS16045	COG1560	Kdo2-lipid A biosynthetic process
HV239_RS16060	COG5645	(Lipo)protein
HV239_RS16095	COG3381	protein complex oligomerization
HV239_RS16115	COG0583	DNA-binding transcription factor activity
HV239_RS16125	COG1335	isochorismatase
HV239_RS16200	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HV239_RS16205	COG1702	phosphate starvation-inducible protein PhoH
HV239_RS16225	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV239_RS16235	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HV239_RS16250	COG1309	transcriptional regulator
HV239_RS16285	COG2233	PERMEase
HV239_RS16295	COG3729	General stress protein
HV239_RS16325	COG1028	Short-chain dehydrogenase reductase Sdr
HV239_RS16340	COG0531	amino acid
HV239_RS16345	COG0174	glutamine synthetase
HV239_RS16350	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HV239_RS16355	COG1396	sequence-specific DNA binding
HV239_RS16355	COG1917	Cupin 2, conserved barrel domain protein
HV239_RS16360	COG1012	belongs to the aldehyde dehydrogenase family
HV239_RS16365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HV239_RS16370	COG0583	DNA-binding transcription factor activity
HV239_RS16375	COG0473	3-isopropylmalate dehydrogenase activity
HV239_RS16380	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HV239_RS16385	COG4638	Rieske (2fe-2S)
HV239_RS16390	COG1012	belongs to the aldehyde dehydrogenase family
HV239_RS16395	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV239_RS16415	COG0670	Belongs to the BI1 family
HV239_RS16430	COG2207	Transcriptional regulator
HV239_RS16435	COG1881	PFAM PEBP family protein
HV239_RS16460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV239_RS16465	COG2274	protein secretion by the type I secretion system
HV239_RS16480	COG4372	Transposase
HV239_RS16485	COG3436	PFAM IS66 Orf2 family protein
HV239_RS16500	COG1832	CoA-binding protein
HV239_RS16510	COG0210	DNA helicase
HV239_RS16515	COG3304	Inner membrane component domain
HV239_RS16520	COG1289	transmembrane transporter activity
HV239_RS16525	COG3070	regulator of competence-specific genes
HV239_RS16550	COG1067	ATP-dependent peptidase activity
HV239_RS16560	COG3130	regulation of translation
HV239_RS16565	COG3009	Protein conserved in bacteria
HV239_RS16570	COG3008	intermembrane lipid transfer
HV239_RS16570	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HV239_RS16575	COG2995	paraquat-inducible protein a
HV239_RS16580	COG0488	(ABC) transporter
HV239_RS16590	COG3217	Mosc domain protein beta barrel domain protein
HV239_RS16590	COG0633	Ferredoxin
HV239_RS16605	COG0431	NADPH-dependent FMN reductase
HV239_RS16610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HV239_RS16615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV239_RS16620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV239_RS16630	COG0308	aminopeptidase N
HV239_RS16650	COG0814	amino acid
HV239_RS16670	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV239_RS16675	COG1448	Aminotransferase
HV239_RS16680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV239_RS16685	COG3108	Peptidase M15
HV239_RS16690	COG2989	Protein conserved in bacteria
HV239_RS16700	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HV239_RS16710	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HV239_RS16715	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HV239_RS16720	COG3173	Aminoglycoside phosphotransferase
HV239_RS16735	COG3214	Protein conserved in bacteria
HV239_RS16750	COG0658	competence protein
HV239_RS16750	COG2333	competence protein COMEC
HV239_RS16760	COG0539	negative regulation of cytoplasmic translation
HV239_RS16780	COG2323	membrane
HV239_RS16785	COG1944	ATP diphosphatase activity
HV239_RS16790	COG2116	formate transmembrane transporter activity
HV239_RS16795	COG1882	Formate acetyltransferase
HV239_RS16800	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV239_RS16805	COG0477	Major facilitator Superfamily
HV239_RS16810	COG3302	dmso reductase anchor subunit
HV239_RS16815	COG0437	4 iron, 4 sulfur cluster binding
HV239_RS16820	COG0243	molybdopterin cofactor binding
HV239_RS16830	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HV239_RS16840	COG1178	ABC-type Fe3 transport system permease component
HV239_RS16840	COG1674	ftsk spoiiie
HV239_RS16850	COG0492	ferredoxin-NADP+ reductase activity
HV239_RS16855	COG4988	ABC transporter
HV239_RS16860	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HV239_RS16875	COG0542	response to heat
HV239_RS16885	COG1278	Cold shock
HV239_RS16895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV239_RS16900	COG3593	DNA synthesis involved in DNA repair
HV239_RS16910	COG2431	L-lysine efflux transmembrane transporter activity
HV239_RS16920	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV239_RS16930	COG0028	Belongs to the TPP enzyme family
HV239_RS16935	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HV239_RS16940	COG0702	epimerase
HV239_RS16945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV239_RS16950	COG3023	N-Acetylmuramoyl-L-alanine amidase
HV239_RS16955	COG3706	GGDEF domain
HV239_RS16955	COG5001	Diguanylate cyclase
HV239_RS16955	COG2203	Gaf domain
HV239_RS16955	COG4251	negative regulation of phosphorylation
HV239_RS16965	COG1126	abc transporter atp-binding protein
HV239_RS16970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV239_RS16975	COG4215	(ABC) transporter
HV239_RS16980	COG4160	amino acid transport
HV239_RS16985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV239_RS16990	COG5002	protein histidine kinase activity
HV239_RS16995	COG0745	RESPONSE REGULATOR receiver
HV239_RS17010	COG1177	transmembrane transport
HV239_RS17015	COG1176	ABC-type spermidine putrescine transport system, permease component I
HV239_RS17020	COG3842	ATPase activity
HV239_RS17025	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HV239_RS17040	COG0778	Nitroreductase
HV239_RS17065	COG3226	Transcriptional regulator
HV239_RS17070	COG0738	Major facilitator superfamily
HV239_RS17075	COG0561	phosphatase activity
HV239_RS17080	COG2814	Major facilitator Superfamily
HV239_RS17085	COG0671	phosphoesterase, PA-phosphatase related
HV239_RS17090	COG1349	DNA-binding transcription factor activity
HV239_RS17095	COG1686	Belongs to the peptidase S11 family
HV239_RS17105	COG0625	glutathione transferase activity
HV239_RS17110	COG2133	pyrroloquinoline quinone binding
HV239_RS17120	COG2223	nitrite transmembrane transporter activity
HV239_RS17140	COG0747	negative chemotaxis
HV239_RS17155	COG0303	'Molybdopterin
HV239_RS17160	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HV239_RS17165	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV239_RS17170	COG1882	Formate acetyltransferase
HV239_RS17175	COG0561	phosphatase activity
HV239_RS17185	COG1609	Transcriptional regulator
HV239_RS17190	COG2271	Major facilitator Superfamily
HV239_RS17200	COG0488	(ABC) transporter
HV239_RS17205	COG2365	Tyrosine phosphatase family
HV239_RS17210	COG1376	ErfK ybiS ycfS ynhG family protein
HV239_RS17215	COG2188	Transcriptional regulator
HV239_RS17220	COG2723	6-phospho-beta-galactosidase activity
HV239_RS17225	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HV239_RS17240	COG2194	sulfuric ester hydrolase activity
HV239_RS17245	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HV239_RS17260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV239_RS17265	COG0765	amino acid transport
HV239_RS17270	COG1126	abc transporter atp-binding protein
HV239_RS17275	COG0668	transmembrane transport
HV239_RS17285	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HV239_RS17295	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HV239_RS17305	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HV239_RS17310	COG1199	ATP-dependent helicase activity
HV239_RS17315	COG0513	Belongs to the DEAD box helicase family
HV239_RS17320	COG3958	Transketolase
HV239_RS17325	COG3959	Transketolase, thiamine diphosphate binding domain
HV239_RS17330	COG1028	Short-chain dehydrogenase reductase Sdr
HV239_RS17345	COG0583	DNA-binding transcription factor activity
HV239_RS17350	COG1309	transcriptional regulator
HV239_RS17355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV239_RS17360	COG1131	(ABC) transporter
HV239_RS17365	COG0842	Transport permease protein
HV239_RS17370	COG0842	Transport permease protein
HV239_RS17380	COG3568	Endonuclease Exonuclease Phosphatase
HV239_RS17385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV239_RS17390	COG0392	lysyltransferase activity
HV239_RS17395	COG0670	Belongs to the BI1 family
HV239_RS17400	COG0314	molybdopterin synthase activity
HV239_RS17405	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HV239_RS17415	COG0521	Mo-molybdopterin cofactor biosynthetic process
HV239_RS17435	COG0745	RESPONSE REGULATOR receiver
HV239_RS17440	COG0642	Histidine kinase
HV239_RS17465	COG2226	methyltransferase
HV239_RS17480	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HV239_RS17485	COG1881	PFAM PEBP family protein
HV239_RS17525	COG4677	pectinesterase activity
HV239_RS17540	COG0589	response to stress
HV239_RS17545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV239_RS17585	COG0789	Transcriptional regulator
HV239_RS17590	COG2200	EAL domain
HV239_RS17615	COG0561	phosphatase activity
HV239_RS17625	COG4149	molybdate abc transporter
HV239_RS17630	COG0725	ABC transporter, periplasmic molybdate-binding protein
HV239_RS17640	COG3585	molybdate ion transport
HV239_RS17640	COG2005	Transcriptional regulator
HV239_RS17645	COG1119	ATPase activity
HV239_RS17655	COG1085	galactose-1-phosphate uridylyltransferase
HV239_RS17665	COG2017	converts alpha-aldose to the beta-anomer
HV239_RS17675	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV239_RS17690	COG3201	nicotinamide mononucleotide transporter
HV239_RS17695	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HV239_RS17745	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HV239_RS17750	COG2885	chlorophyll binding
HV239_RS17760	COG3064	Membrane
HV239_RS17765	COG0848	biopolymer transport protein
HV239_RS17770	COG0811	peptide transport
HV239_RS17775	COG0824	Thioesterase
HV239_RS17780	COG3790	cyd operon protein YbgE
HV239_RS17785	COG4890	Cyd operon protein YbgT
HV239_RS17790	COG1294	oxidase, subunit
HV239_RS17795	COG1271	oxidase subunit
HV239_RS17800	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV239_RS17810	COG0508	dehydrogenase complex catalyzes the overall conversion of
HV239_RS17815	COG0567	Dehydrogenase, E1 component
HV239_RS17820	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HV239_RS17825	COG1053	succinate dehydrogenase
HV239_RS17830	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HV239_RS17835	COG2009	succinate dehydrogenase
HV239_RS17870	COG1984	allophanate hydrolase subunit 2
HV239_RS17875	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HV239_RS17890	COG0415	Belongs to the DNA photolyase family
HV239_RS17920	COG2205	protein histidine kinase activity
HV239_RS17925	COG0745	RESPONSE REGULATOR receiver
HV239_RS17935	COG0033	Phosphoglucomutase
HV239_RS17945	COG0596	Alpha beta hydrolase
HV239_RS17960	COG0735	belongs to the Fur family
HV239_RS18000	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV239_RS18005	COG1940	carbohydrate kinase activity
HV239_RS18005	COG1846	Transcriptional regulator
HV239_RS18010	COG0647	UMP catabolic process
HV239_RS18015	COG0367	asparagine synthase
HV239_RS18055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV239_RS18065	COG1702	phosphate starvation-inducible protein PhoH
HV239_RS18090	COG0765	amino acid transport
HV239_RS18095	COG0765	amino acid transport
HV239_RS18100	COG1126	abc transporter atp-binding protein
HV239_RS18115	COG2888	peptidyl-tyrosine sulfation
HV239_RS18130	COG1466	dna polymerase III delta subunit
HV239_RS18145	COG0799	negative regulation of ribosome biogenesis
HV239_RS18155	COG0768	penicillin binding
HV239_RS18160	COG0772	Belongs to the SEDS family
HV239_RS18165	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV239_RS18170	COG1686	Belongs to the peptidase S11 family
HV239_RS18185	COG0583	DNA-binding transcription factor activity
HV239_RS18200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV239_RS18220	COG3069	C4-dicarboxylate transmembrane transporter activity
HV239_RS18225	COG3719	Belongs to the RNase T2 family
HV239_RS18230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HV239_RS18250	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HV239_RS18255	COG0583	DNA-binding transcription factor activity
HV239_RS18260	COG3969	phosphoadenosine phosphosulfate
HV239_RS18265	COG1475	DNA binding
HV239_RS18270	COG0436	Aminotransferase
HV239_RS18295	COG1129	ABC transporter
HV239_RS18300	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV239_RS18305	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV239_RS18315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV239_RS18330	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HV239_RS18340	COG0402	S-adenosylhomocysteine deaminase activity
HV239_RS18350	COG0483	inositol monophosphate 1-phosphatase activity
HV239_RS18355	COG2271	Major facilitator Superfamily
HV239_RS18385	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV239_RS18390	COG1129	ABC transporter
HV239_RS18395	COG0371	Dehydrogenase
HV239_RS18400	COG1028	Short-chain dehydrogenase reductase Sdr
HV239_RS18415	COG2879	small protein
HV239_RS18420	COG1966	Carbon starvation protein
HV239_RS18430	COG1028	Short-chain dehydrogenase reductase Sdr
HV239_RS18435	COG3433	isochorismatase activity
HV239_RS18435	COG1535	isochorismatase
HV239_RS18440	COG1021	2,3-dihydroxybenzoate-AMP ligase
HV239_RS18445	COG1169	isochorismate synthase
HV239_RS18450	COG4592	Periplasmic binding protein
HV239_RS18460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV239_RS18465	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV239_RS18470	COG1120	ATPase activity
HV239_RS18475	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HV239_RS18475	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HV239_RS18480	COG3251	PFAM MbtH domain protein
HV239_RS18485	COG2382	esterase
HV239_RS18490	COG4771	TonB-dependent receptor
HV239_RS18495	COG2977	Belongs to the P-Pant transferase superfamily
HV239_RS18500	COG3958	Transketolase
HV239_RS18505	COG3959	Transketolase, thiamine diphosphate binding domain
HV239_RS18510	COG2390	Transcriptional regulator
HV239_RS18515	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HV239_RS18520	COG1879	ABC-type sugar transport system periplasmic component
HV239_RS18530	COG1129	ABC transporter
HV239_RS18535	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV239_RS18545	COG1028	Short-chain dehydrogenase reductase Sdr
HV239_RS18555	COG0583	DNA-binding transcription factor activity
HV239_RS18560	COG0668	transmembrane transport
HV239_RS18570	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HV239_RS18595	COG0747	negative chemotaxis
HV239_RS18600	COG0601	transmembrane transport
HV239_RS18605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV239_RS18610	COG0444	Belongs to the ABC transporter superfamily
HV239_RS18615	COG4608	Belongs to the ABC transporter superfamily
HV239_RS18625	COG4221	oxidoreductase activity
HV239_RS18635	COG4215	(ABC) transporter
HV239_RS18640	COG0765	amino acid transport
HV239_RS18645	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HV239_RS18660	COG0697	spore germination
HV239_RS18670	COG3698	Phosphodiester glycosidase
HV239_RS18710	COG2315	Protein conserved in bacteria
HV239_RS18715	COG0778	Nitroreductase
HV239_RS18740	COG0477	Major facilitator Superfamily
HV239_RS18745	COG0668	transmembrane transport
HV239_RS18770	COG2211	Major facilitator Superfamily
HV239_RS18775	COG1113	amino acid transport
HV239_RS18790	COG1012	belongs to the aldehyde dehydrogenase family
HV239_RS18795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HV239_RS18805	COG0531	amino acid
HV239_RS18820	COG4680	protein conserved in bacteria
HV239_RS18865	COG0667	Aldo Keto reductase
HV239_RS18870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV239_RS18875	COG1473	amidohydrolase
HV239_RS18905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV239_RS18910	COG1120	ATPase activity
HV239_RS18915	COG1566	PFAM secretion protein HlyD family protein
HV239_RS18960	COG4211	Belongs to the binding-protein-dependent transport system permease family
HV239_RS18965	COG1129	ABC transporter
HV239_RS18980	COG0673	inositol 2-dehydrogenase activity
HV239_RS19010	COG3104	oligopeptide transport
HV239_RS19015	COG1982	Orn Lys Arg decarboxylase major
HV239_RS19020	COG0531	amino acid
HV239_RS19025	COG3710	Transcriptional regulator
HV239_RS19035	COG1560	Kdo2-lipid A biosynthetic process
HV239_RS19080	COG3039	Transposase
HV239_RS19120	COG1196	nuclear chromosome segregation
HV239_RS19200	COG3728	DNA packaging
HV239_RS19200	COG5484	DNA packaging
HV239_RS19450	COG2501	S4 domain
HV239_RS19460	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HV239_RS19480	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HV239_RS19485	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HV239_RS19505	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HV239_RS19510	COG4181	ATPase activity
HV239_RS19515	COG2755	lipolytic protein G-D-S-L family
HV239_RS19520	COG0300	oxidoreductase activity
HV239_RS19525	COG3118	belongs to the thioredoxin family
HV239_RS19530	COG0390	transport system, permease component
HV239_RS19535	COG4619	ABC transporter
HV239_RS19540	COG0330	HflC and HflK could
HV239_RS19545	COG1585	Membrane protein implicated in regulation of membrane protease activity
HV239_RS19560	COG3735	TraB family
HV239_RS19565	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV239_RS19575	COG2223	nitrite transmembrane transporter activity
HV239_RS19580	COG4651	solute:proton antiporter activity
HV239_RS19580	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HV239_RS19585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV239_RS19625	COG2832	Protein of unknown function (DUF454)
HV239_RS19630	COG3923	Primosomal replication protein n
HV239_RS19645	COG1196	nuclear chromosome segregation
HV239_RS19645	COG3264	Mechanosensitive ion channel
HV239_RS19655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV239_RS19660	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV239_RS19675	COG0110	maltose O-acetyltransferase activity
HV239_RS19725	COG1874	Beta-galactosidase
HV239_RS19730	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HV239_RS19735	COG3833	ABC-type maltose transport systems, permease component
HV239_RS19740	COG1175	transmembrane transport
HV239_RS19745	COG2182	Extracellular solute-binding protein
HV239_RS19755	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV239_RS19770	COG2364	Membrane
HV239_RS19825	COG3039	Transposase
HV239_RS19855	COG0582	viral genome integration into host DNA
HV239_RS19870	COG3695	enzyme binding
HV239_RS19875	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HV239_RS19880	COG1946	Acyl-CoA thioesterase
HV239_RS19885	COG0004	ammonium transporteR
HV239_RS19890	COG0347	Belongs to the P(II) protein family
HV239_RS19895	COG1132	(ABC) transporter
HV239_RS19900	COG1132	(ABC) transporter
HV239_RS19905	COG1522	sequence-specific DNA binding
HV239_RS19920	COG4533	DNA binding
HV239_RS19930	COG0824	Thioesterase
HV239_RS19935	COG1555	photosystem II stabilization
HV239_RS19940	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV239_RS19945	COG0776	regulation of translation
HV239_RS19950	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HV239_RS19970	COG0271	Belongs to the BolA IbaG family
HV239_RS19975	COG3056	Lipoprotein
HV239_RS19980	COG2223	nitrite transmembrane transporter activity
HV239_RS19985	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HV239_RS19990	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HV239_RS19995	COG1845	cytochrome c oxidase, subunit III
HV239_RS20000	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HV239_RS20015	COG1414	Transcriptional regulator
HV239_RS20020	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HV239_RS20025	COG1053	succinate dehydrogenase
HV239_RS20035	COG1053	succinate dehydrogenase
HV239_RS20050	COG0673	inositol 2-dehydrogenase activity
HV239_RS20055	COG2814	Major facilitator Superfamily
HV239_RS20065	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HV239_RS20070	COG0693	protein deglycase activity
HV239_RS20090	COG0142	geranyltranstransferase activity
HV239_RS20100	COG0667	Aldo Keto reductase
HV239_RS20105	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HV239_RS20125	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HV239_RS20125	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HV239_RS20135	COG4238	major outer membrane lipoprotein
HV239_RS20155	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HV239_RS20160	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HV239_RS20165	COG1862	Preprotein translocase
HV239_RS20190	COG0450	alkyl hydroperoxide reductase
HV239_RS20195	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV239_RS20210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV239_RS20220	COG1228	amidohydrolase
HV239_RS20230	COG1335	isochorismatase
HV239_RS20235	COG0583	DNA-binding transcription factor activity
HV239_RS20240	COG0366	Alpha amylase catalytic
HV239_RS20265	COG0420	3'-5' exonuclease activity
HV239_RS20270	COG0419	ATPase involved in DNA repair
HV239_RS20275	COG1940	carbohydrate kinase activity
HV239_RS20290	COG4126	flavin adenine dinucleotide binding
HV239_RS20300	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HV239_RS20305	COG3416	Protein conserved in bacteria
HV239_RS20315	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HV239_RS20325	COG1785	Belongs to the alkaline phosphatase family
HV239_RS20365	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HV239_RS20370	COG1335	isochorismatase
HV239_RS20375	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HV239_RS20380	COG0113	porphobilinogen synthase activity
HV239_RS20385	COG1943	Transposase
HV239_RS20395	COG2175	clavaminate synthase activity
HV239_RS20400	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV239_RS20405	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HV239_RS20410	COG4521	taurine ABC transporter
HV239_RS20415	COG2040	homocysteine
HV239_RS20420	COG0833	amino acid
HV239_RS20435	COG4303	Ethanolamine ammonia lyase large subunit
HV239_RS20440	COG4302	ethanolamine ammonia-lyase activity
HV239_RS20480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV239_RS20485	COG1126	abc transporter atp-binding protein
HV239_RS20490	COG4597	amino acid ABC transporter
HV239_RS20495	COG0765	amino acid transport
HV239_RS20510	COG3188	usher protein
HV239_RS20535	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HV239_RS20545	COG3639	organic phosphonate transmembrane transporter activity
HV239_RS20565	COG0791	NLP P60 protein
HV239_RS20595	COG4581	dead DEAH box helicase
HV239_RS20610	COG2909	trisaccharide binding
HV239_RS20615	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HV239_RS20620	COG0022	dehydrogenase e1 component
HV239_RS20625	COG0508	dehydrogenase complex catalyzes the overall conversion of
HV239_RS20630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV239_RS20650	COG1070	Carbohydrate kinase
HV239_RS20655	COG1028	Short-chain dehydrogenase reductase Sdr
HV239_RS20660	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV239_RS20665	COG3775	system Galactitol-specific IIC component
HV239_RS20670	COG0625	glutathione transferase activity
HV239_RS20675	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HV239_RS20690	COG0579	oxidoreductase
HV239_RS20695	COG1012	belongs to the aldehyde dehydrogenase family
HV239_RS20700	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV239_RS20705	COG1113	amino acid transport
HV239_RS20710	COG1802	Transcriptional regulator
HV239_RS20730	COG2195	Cleaves the N-terminal amino acid of tripeptides
HV239_RS20735	COG0454	-acetyltransferase
HV239_RS20750	COG2991	Protein conserved in bacteria
HV239_RS20765	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HV239_RS20770	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HV239_RS20785	COG3034	peptidoglycan biosynthetic process
HV239_RS20790	COG0121	glutamine amidotransferase
HV239_RS20800	COG1960	acyl-CoA dehydrogenase activity
HV239_RS20805	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV239_RS20815	COG0583	DNA-binding transcription factor activity
HV239_RS20825	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV239_RS20835	COG2226	methyltransferase
HV239_RS20845	COG0741	lytic transglycosylase activity
HV239_RS20845	COG1388	LysM domain
HV239_RS20850	COG2226	methyltransferase
HV239_RS20860	COG2814	Major facilitator Superfamily
HV239_RS20865	COG0583	DNA-binding transcription factor activity
HV239_RS20870	COG0656	L-ascorbic acid biosynthetic process
HV239_RS20905	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HV239_RS20915	COG2011	ABC-type metal ion transport system permease component
HV239_RS20920	COG1464	Belongs to the NlpA lipoprotein family
HV239_RS20930	COG1720	tRNA m6t6A37 methyltransferase activity
HV239_RS20940	COG0791	NLP P60 protein
HV239_RS20945	COG3015	lipoprotein NlpE involved in copper resistance
HV239_RS20950	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HV239_RS20965	COG4568	rho-dependent transcription termination
HV239_RS20975	COG0346	lactoylglutathione lyase activity
HV239_RS20990	COG0587	DNA-directed DNA polymerase activity
HV239_RS21020	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HV239_RS21030	COG0750	zinc metalloprotease
HV239_RS21035	COG0575	Belongs to the CDS family
HV239_RS21045	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HV239_RS21070	COG0024	Methionine aminopeptidase
HV239_RS21075	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HV239_RS21090	COG3835	regulator
HV239_RS21095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV239_RS21115	COG2860	membrane
HV239_RS21135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV239_RS21140	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HV239_RS21145	COG1120	ATPase activity
HV239_RS21155	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HV239_RS21250	COG1643	Atp-dependent helicase
HV239_RS21255	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HV239_RS21275	COG0617	tRNA 3'-terminal CCA addition
HV239_RS21280	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HV239_RS21300	COG0726	polysaccharide deacetylase
HV239_RS21305	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV239_RS21310	COG0842	Transport permease protein
HV239_RS21315	COG1131	(ABC) transporter
HV239_RS21320	COG0288	reversible hydration of carbon dioxide
HV239_RS21335	COG4993	Dehydrogenase
HV239_RS21340	COG2132	Multicopper oxidase
HV239_RS21385	COG3064	Membrane
HV239_RS21400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV239_RS21405	COG0508	dehydrogenase complex catalyzes the overall conversion of
HV239_RS21410	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HV239_RS21415	COG2186	Transcriptional regulator
HV239_RS21420	COG1113	amino acid transport
HV239_RS21425	COG2211	Major facilitator Superfamily
HV239_RS21430	COG3940	Belongs to the glycosyl hydrolase 43 family
HV239_RS21435	COG3725	Membrane protein required for beta-lactamase induction
HV239_RS21440	COG3023	N-Acetylmuramoyl-L-alanine amidase
HV239_RS21450	COG4969	Belongs to the N-Me-Phe pilin family
HV239_RS21455	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HV239_RS21460	COG1459	type II secretion system
HV239_RS21485	COG0494	nUDIX hydrolase
HV239_RS21505	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HV239_RS21510	COG0849	cell division
HV239_RS21535	COG0772	Belongs to the SEDS family
HV239_RS21550	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HV239_RS21555	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HV239_RS21560	COG0768	penicillin binding
HV239_RS21580	COG1609	Transcriptional regulator
HV239_RS21590	COG0028	Belongs to the TPP enzyme family
HV239_RS21635	COG0738	Major facilitator superfamily
HV239_RS21645	COG0583	DNA-binding transcription factor activity
HV239_RS21650	COG2271	Major facilitator Superfamily
HV239_RS21655	COG2814	Major facilitator Superfamily
HV239_RS21675	COG1178	ABC-type Fe3 transport system permease component
HV239_RS21685	COG0586	Pfam SNARE associated Golgi protein
HV239_RS21705	COG0235	Class ii aldolase
HV239_RS21710	COG0417	DNA replication proofreading
HV239_RS21720	COG0564	pseudouridine synthase activity
HV239_RS21730	COG3493	citrate carrier protein
HV239_RS21745	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HV239_RS21750	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HV239_RS21760	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HV239_RS21805	COG0505	Belongs to the CarA family
HV239_RS21815	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HV239_RS21840	COG1047	Peptidyl-prolyl cis-trans
HV239_RS21855	COG0196	riboflavin kinase activity
HV239_RS21865	COG0583	DNA-binding transcription factor activity
HV239_RS21890	COG4735	regulation of single-species biofilm formation
HV239_RS21895	COG1584	GPR1 FUN34 yaaH family protein
HV239_RS21900	COG0477	Major facilitator Superfamily
HV239_RS21905	COG0521	Mo-molybdopterin cofactor biosynthetic process
HV239_RS21910	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HV239_RS21930	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HV239_RS21940	COG0460	homoserine dehydrogenase
HV239_RS21940	COG0527	aspartate kinase activity
HV239_RS21950	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HV239_RS21960	COG0745	RESPONSE REGULATOR receiver
HV239_RS21965	COG4452	Inner membrane protein CreD
HV239_RS21970	COG2205	protein histidine kinase activity
HV239_RS21975	COG0745	RESPONSE REGULATOR receiver
HV239_RS21980	COG3045	CreA protein
HV239_RS21985	COG3708	Transcriptional regulator
HV239_RS21985	COG2207	Transcriptional regulator
HV239_RS22005	COG0741	lytic transglycosylase activity
HV239_RS22010	COG0488	(ABC) transporter
HV239_RS22020	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HV239_RS22025	COG0560	Phosphoserine phosphatase
HV239_RS22030	COG3726	membrane protein affecting hemolysin expression
HV239_RS22060	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV239_RS22065	COG0084	hydrolase, TatD family'
HV239_RS22070	COG4667	esterase of the alpha-beta hydrolase superfamily
HV239_RS22080	COG2823	Periplasmic or secreted lipoprotein
HV239_RS22090	COG1011	Hydrolase
HV239_RS22095	COG0456	acetyltransferase
HV239_RS22100	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HV239_RS22135	COG3706	GGDEF domain
HV239_RS22140	COG4114	ferric iron reductase
HV239_RS22145	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV239_RS22145	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV239_RS22150	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV239_RS22155	COG2197	response regulator
HV239_RS22160	COG2197	response regulator
HV239_RS22175	COG2966	Psort location CytoplasmicMembrane, score
HV239_RS22190	COG1484	DNA-dependent DNA replication
HV239_RS22205	COG5464	transposase or invertase
HV239_RS22215	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HV239_RS22220	COG3716	PTS system mannose fructose sorbose family IID component
HV239_RS22225	COG3715	PTS system
HV239_RS22240	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HV239_RS22240	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HV239_RS22245	COG1214	PFAM Peptidase M22, glycoprotease
HV239_RS22245	COG0456	acetyltransferase
HV239_RS22255	COG1737	Transcriptional regulator
HV239_RS22260	COG0800	Aldolase
HV239_RS22265	COG3734	2-keto-3-deoxy-galactonokinase
HV239_RS22280	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HV239_RS22310	COG1846	Transcriptional regulator
HV239_RS22320	COG0179	Fumarylacetoacetate (FAA) hydrolase
HV239_RS22330	COG1012	belongs to the aldehyde dehydrogenase family
HV239_RS22335	COG3384	dioxygenase
HV239_RS22345	COG3971	2-oxopent-4-enoate hydratase activity
HV239_RS22365	COG2368	4-hydroxyphenylacetate
HV239_RS22370	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HV239_RS22380	COG3039	Transposase
HV239_RS22390	COG1966	Carbon starvation protein
HV239_RS22395	COG2879	small protein
HV239_RS22400	COG0523	cobalamin synthesis protein
HV239_RS22410	COG1012	belongs to the aldehyde dehydrogenase family
HV239_RS22415	COG5464	transposase or invertase
HV239_RS22420	COG1917	Cupin 2, conserved barrel domain protein
HV239_RS22420	COG2207	Transcriptional regulator
HV239_RS22430	COG2733	membrane
HV239_RS22445	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HV239_RS22450	COG1924	4 iron, 4 sulfur cluster binding
HV239_RS22465	COG1566	PFAM secretion protein HlyD family protein
HV239_RS22475	COG5457	Domain of unknown function (DUF1127)
HV239_RS22480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV239_RS22490	COG0583	DNA-binding transcription factor activity
HV239_RS22495	COG2249	NAD(P)H dehydrogenase (quinone) activity
HV239_RS22505	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV239_RS22510	COG1129	ABC transporter
HV239_RS22515	COG1879	ABC-type sugar transport system periplasmic component
HV239_RS22525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV239_RS22530	COG0842	Transport permease protein
HV239_RS22530	COG1129	ABC transporter
HV239_RS22535	COG0842	Transport permease protein
HV239_RS22565	COG2850	peptidyl-arginine hydroxylation
HV239_RS22580	COG5002	protein histidine kinase activity
HV239_RS22585	COG0745	RESPONSE REGULATOR receiver
HV239_RS22590	COG1538	Outer membrane efflux protein
HV239_RS22595	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV239_RS22600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV239_RS22605	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV239_RS22615	COG3040	lipid binding
HV239_RS22620	COG0789	Transcriptional regulator
HV239_RS22630	COG0300	oxidoreductase activity
HV239_RS22645	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HV239_RS22665	COG3272	Protein of unknown function (DUF1722)
HV239_RS22670	COG4580	involved in the transport of maltose and maltodextrins
HV239_RS22675	COG2115	Belongs to the xylose isomerase family
HV239_RS22680	COG2211	Major facilitator Superfamily
HV239_RS22685	COG3507	Belongs to the glycosyl hydrolase 43 family
HV239_RS22705	COG1216	Glycosyl transferase, family 2
HV239_RS22835	COG3039	Transposase
HV239_RS22850	COG0288	reversible hydration of carbon dioxide
HV239_RS22855	COG0659	secondary active sulfate transmembrane transporter activity
HV239_RS22860	COG1064	alcohol dehydrogenase
HV239_RS22865	COG1175	transmembrane transport
HV239_RS22870	COG0395	ABC-type sugar transport system, permease component
HV239_RS22875	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HV239_RS22880	COG3842	ATPase activity
HV239_RS22895	COG1082	Xylose isomerase domain protein TIM barrel
HV239_RS22905	COG3962	Belongs to the TPP enzyme family
HV239_RS22910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV239_RS22915	COG0837	glucose binding
HV239_RS22915	COG1737	Transcriptional regulator
HV239_RS22920	COG3718	enzyme involved in inositol metabolism
HV239_RS22935	COG0433	COG0433 Predicted ATPase
HV239_RS22940	COG0795	lipopolysaccharide-transporting ATPase activity
HV239_RS22945	COG0795	lipopolysaccharide-transporting ATPase activity
HV239_RS22955	COG2927	DNA polymerase III (CHI subunit)
HV239_RS22960	COG0525	valine-tRNA ligase activity
HV239_RS22985	COG2731	YhcH YjgK YiaL family protein
HV239_RS23020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV239_RS23020	COG1263	PTS System
HV239_RS23025	COG0366	Alpha amylase catalytic
HV239_RS23030	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV239_RS23035	COG1486	melibiose metabolic process
HV239_RS23060	COG0602	queuosine metabolic process
HV239_RS23065	COG2026	Addiction module toxin, RelE StbE family
HV239_RS23070	COG3077	Addiction module antitoxin, RelB DinJ family
HV239_RS23075	COG3711	transcriptional antiterminator
HV239_RS23075	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV239_RS23080	COG2706	6-phosphogluconolactonase activity
HV239_RS23095	COG3964	amidohydrolase
HV239_RS23135	COG0312	modulator of DNA gyrase
HV239_RS23160	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HV239_RS23170	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV239_RS23175	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV239_RS23180	COG1129	ABC transporter
HV239_RS23185	COG1879	ABC-type sugar transport system periplasmic component
HV239_RS23200	COG2105	PFAM AIG2 family protein
HV239_RS23205	COG2911	Protein conserved in bacteria
HV239_RS23210	COG0729	surface antigen
HV239_RS23220	COG1253	flavin adenine dinucleotide binding
HV239_RS23235	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HV239_RS23250	COG1733	regulation of RNA biosynthetic process
HV239_RS23255	COG0702	epimerase
HV239_RS23265	COG0697	spore germination
HV239_RS23275	COG1113	amino acid transport
HV239_RS23280	COG0545	Peptidyl-prolyl cis-trans isomerase
HV239_RS23285	COG3061	Opacity-associated protein A
HV239_RS23295	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HV239_RS23300	COG2965	DNA replication, synthesis of RNA primer
HV239_RS23360	COG1073	alpha beta
HV239_RS23365	COG3650	response to hydrogen peroxide
HV239_RS23375	COG1960	acyl-CoA dehydrogenase activity
HV239_RS23380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV239_RS23385	COG0557	exoribonuclease II activity
HV239_RS23400	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HV239_RS23410	COG0330	HflC and HflK could
HV239_RS23415	COG0330	HflC and HflK could
HV239_RS23420	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HV239_RS23440	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV239_RS23445	COG0802	atpase or kinase
HV239_RS23450	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HV239_RS23450	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HV239_RS23455	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HV239_RS23475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV239_RS23495	COG1511	domain protein
HV239_RS23495	COG3264	Mechanosensitive ion channel
HV239_RS23510	COG1053	succinate dehydrogenase
HV239_RS23515	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HV239_RS23535	COG2076	Multidrug Resistance protein
HV239_RS23540	COG5510	response to toxic substance
HV239_RS23555	COG1509	lysine 2,3-aminomutase activity
HV239_RS23620	COG0531	amino acid
HV239_RS23625	COG3030	protein affecting phage T7 exclusion by the F plasmid
HV239_RS23630	COG1027	Aspartate ammonia-lyase
HV239_RS23635	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV239_RS23650	COG1309	transcriptional regulator
HV239_RS23680	COG0457	Tetratricopeptide repeat
HV239_RS23685	COG0726	polysaccharide deacetylase
HV239_RS23685	COG1649	PFAM Uncharacterised BCR, COG1649
HV239_RS23690	COG1215	transferase activity, transferring glycosyl groups
HV239_RS23705	COG0861	Integral membrane protein TerC family
HV239_RS23750	COG1486	melibiose metabolic process
HV239_RS23755	COG2169	Transcriptional regulator
HV239_RS23765	COG2824	Alkylphosphonate utilization operon protein PhnA
HV239_RS23770	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HV239_RS23775	COG2188	Transcriptional regulator
HV239_RS23780	COG3624	Phosphonate C-P lyase system protein PhnG
HV239_RS23785	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HV239_RS23790	COG3626	phosphonate metabolism
HV239_RS23795	COG3627	carbon phosphorus lyase activity
HV239_RS23800	COG4107	phosphonate C-P lyase system protein PhnK
HV239_RS23805	COG4778	phosphonate C-P lyase system protein PhnL
HV239_RS23810	COG3454	Phosphonate metabolism
HV239_RS23820	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HV239_RS23830	COG4191	Histidine kinase
HV239_RS23830	COG0784	Response regulator, receiver
HV239_RS23835	COG1129	ABC transporter
HV239_RS23840	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV239_RS23885	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HV239_RS23890	COG1301	dicarboxylic acid transport
HV239_RS23900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HV239_RS23905	COG3162	membrane
HV239_RS23940	COG1380	Effector of murein hydrolase LrgA
HV239_RS23945	COG0583	DNA-binding transcription factor activity
HV239_RS23950	COG0025	NhaP-type Na H and K H
HV239_RS23955	COG2252	PERMEase
HV239_RS23960	COG0625	glutathione transferase activity
HV239_RS23965	COG0789	Transcriptional regulator
HV239_RS23975	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV239_RS24005	COG1234	tRNA 3'-trailer cleavage
HV239_RS24010	COG1609	Transcriptional regulator
HV239_RS24015	COG0483	inositol monophosphate 1-phosphatase activity
HV239_RS24025	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV239_RS24045	COG4771	TonB-dependent receptor
HV239_RS24050	COG0741	lytic transglycosylase activity
HV239_RS24065	COG2315	Protein conserved in bacteria
HV239_RS24070	COG0432	Pfam Uncharacterised protein family UPF0047
HV239_RS24085	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HV239_RS24090	COG0305	Participates in initiation and elongation during chromosome replication
HV239_RS24105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HV239_RS24115	COG0735	belongs to the Fur family
HV239_RS24120	COG3237	CsbD-like
HV239_RS24130	COG0534	Mate efflux family protein
HV239_RS24140	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HV239_RS24195	COG3039	Transposase
HV239_RS24210	COG0251	oxidation-reduction process
HV239_RS24220	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HV239_RS24230	COG0527	aspartate kinase activity
HV239_RS24290	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HV239_RS24300	COG0456	acetyltransferase
HV239_RS24330	COG0151	Belongs to the GarS family
HV239_RS24340	COG4191	Histidine kinase
HV239_RS24345	COG3678	ATP-independent chaperone mediated protein folding
HV239_RS24380	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HV239_RS24395	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HV239_RS24400	COG2104	thiamine diphosphate biosynthetic process
HV239_RS24415	COG3706	GGDEF domain
HV239_RS24425	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV239_RS24430	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV239_RS24465	COG0250	Participates in transcription elongation, termination and antitermination
HV239_RS24500	COG3039	Transposase
HV239_RS24515	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HV239_RS24545	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HV239_RS24555	COG1739	Uncharacterized protein family UPF0029
HV239_RS24595	COG0805	protein transport
HV239_RS24615	COG3165	ubiquinone biosynthetic process from chorismate
HV239_RS24645	COG0583	DNA-binding transcription factor activity
HV239_RS24650	COG0697	spore germination
HV239_RS24655	COG0561	phosphatase activity
HV239_RS24660	COG2267	carboxylic ester hydrolase activity
HV239_RS24665	COG1280	lysine exporter protein (LysE YggA)
HV239_RS24675	COG1280	lysine exporter protein (LysE YggA)
HV239_RS24705	COG0210	DNA helicase
HV239_RS24710	COG1011	Hydrolase
HV239_RS24740	COG3072	Adenylate cyclase
HV239_RS24755	COG2959	enzyme of heme biosynthesis
HV239_RS24760	COG3071	HemY protein
HV239_RS24805	COG2244	polysaccharide biosynthetic process
HV239_RS24810	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HV239_RS24815	COG0456	acetyltransferase
HV239_RS24820	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HV239_RS24825	COG1088	dTDP-glucose 4,6-dehydratase activity
HV239_RS24830	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HV239_RS24835	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HV239_RS24845	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HV239_RS24850	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HV239_RS24855	COG3118	belongs to the thioredoxin family
HV239_RS24880	COG1811	Na channel or pump
HV239_RS24890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV239_RS24895	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV239_RS24905	COG0583	DNA-binding transcription factor activity
HV239_RS24910	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HV239_RS24925	COG3978	acetolactate synthase activity
HV239_RS24945	COG3085	chromosome segregation
HV239_RS25020	COG0583	DNA-binding transcription factor activity
HV239_RS25035	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HV239_RS25050	COG3443	Belongs to the bacterial solute-binding protein 9 family
HV239_RS25055	COG2207	Transcriptional regulator
HV239_RS25065	COG0371	Dehydrogenase
HV239_RS25070	COG0697	spore germination
HV239_RS25080	COG0583	DNA-binding transcription factor activity
HV239_RS25090	COG0737	Belongs to the 5'-nucleotidase family
HV239_RS25100	COG0527	aspartate kinase activity
HV239_RS25100	COG0460	homoserine dehydrogenase
HV239_RS25105	COG0626	cystathionine gamma-synthase activity
HV239_RS25120	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HV239_RS25125	COG1609	Transcriptional regulator
HV239_RS25130	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV239_RS25145	COG1575	Belongs to the MenA family. Type 1 subfamily
HV239_RS25195	COG3678	ATP-independent chaperone mediated protein folding
HV239_RS25200	COG0745	RESPONSE REGULATOR receiver
HV239_RS25205	COG2205	protein histidine kinase activity
HV239_RS25210	COG2258	MOSC domain
HV239_RS25215	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HV239_RS25255	COG1129	ABC transporter
HV239_RS25260	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV239_RS25265	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV239_RS25270	COG1454	alcohol dehydrogenase
HV239_RS25280	COG2211	Major facilitator Superfamily
HV239_RS25340	COG0205	6-phosphofructokinase activity
HV239_RS25360	COG0437	4 iron, 4 sulfur cluster binding
HV239_RS25365	COG2864	formate dehydrogenase
HV239_RS25380	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV239_RS25390	COG0456	acetyltransferase
HV239_RS25405	COG1011	Hydrolase
HV239_RS25420	COG3852	Histidine kinase
HV239_RS25435	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HV239_RS25455	COG0204	Acyl-transferase
HV239_RS25465	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HV239_RS25470	COG3084	Protein conserved in bacteria
HV239_RS25480	COG1763	Mo-molybdopterin cofactor biosynthetic process
HV239_RS25505	COG2186	Transcriptional regulator
HV239_RS25510	COG0477	Major facilitator Superfamily
HV239_RS25515	COG1609	Transcriptional regulator
HV239_RS25520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV239_RS25530	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV239_RS25535	COG1129	ABC transporter
HV239_RS25565	COG1522	sequence-specific DNA binding
HV239_RS25570	COG0716	FMN binding
HV239_RS25585	COG3312	ion transport
HV239_RS25635	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HV239_RS25640	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HV239_RS25645	COG0573	inorganic phosphate transmembrane transporter activity
HV239_RS25650	COG0581	inorganic phosphate transmembrane transporter activity
HV239_RS25655	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HV239_RS25660	COG0704	Plays a role in the regulation of phosphate uptake
HV239_RS25670	COG2382	esterase
HV239_RS25675	COG0363	glucosamine-6-phosphate deaminase activity
HV239_RS25680	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV239_RS25685	COG2252	PERMEase
HV239_RS25690	COG0431	NADPH-dependent FMN reductase
HV239_RS25695	COG2091	lysine biosynthetic process via aminoadipic acid
HV239_RS25725	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HV239_RS25785	COG3039	Transposase
HV239_RS25830	COG3039	Transposase
HV239_RS25880	COG3039	Transposase
HV239_RS25925	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HV239_RS26025	COG2223	nitrite transmembrane transporter activity
HV239_RS26035	COG1609	Transcriptional regulator
HV239_RS26050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV239_RS26115	COG0542	response to heat
HV239_RS26120	COG0071	Belongs to the small heat shock protein (HSP20) family
HV239_RS26160	COG3436	PFAM IS66 Orf2 family protein
HV239_RS26165	COG4372	Transposase
HV239_RS26180	COG3039	Transposase
HV239_RS26200	COG2801	Transposase and inactivated derivatives
HV239_RS26220	COG3039	Transposase
HV239_RS26265	COG2205	protein histidine kinase activity
HV239_RS26270	COG0745	RESPONSE REGULATOR receiver
HV239_RS26275	COG1276	copper resistance
HV239_RS26280	COG2372	response to copper ion
HV239_RS26285	COG3667	copper resistance
HV239_RS26290	COG2132	Multicopper oxidase
HV239_RS26300	COG0739	heme binding
HV239_RS26330	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV239_RS26390	COG3039	Transposase
HV239_RS26435	COG3039	Transposase
HV239_RS26450	COG1160	GTP binding
HV239_RS26455	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HV239_RS26465	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HV239_RS26525	COG0556	nucleotide-excision repair
HV239_RS26540	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HV239_RS26770	COG3039	Transposase
HV239_RS26815	COG5499	transcription regulator containing HTH domain
HV239_RS26860	COG3385	transposase activity
HV239_RS26875	COG2026	Addiction module toxin, RelE StbE family
HV239_RS26880	COG3077	Addiction module antitoxin, RelB DinJ family
HV239_RS26930	COG2814	Major facilitator Superfamily
HV239_RS26945	COG3111	PFAM Bacterial OB fold (BOF) protein
HV239_RS26950	COG2801	Transposase and inactivated derivatives
HV239_RS26965	COG0464	growth
HV239_RS26995	COG1475	DNA binding
HV239_RS27010	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HV239_RS27090	COG3344	reverse transcriptase
HV239_RS27125	COG3077	Addiction module antitoxin, RelB DinJ family
HV239_RS27130	COG3041	Addiction module toxin RelE StbE family
HV239_RS27240	COG1192	Involved in chromosome partitioning
HV239_RS27485	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone