locus-tag	class	description
IOD48_RS00005	COG0538	isocitrate dehydrogenase activity
IOD48_RS00095	COG1403	HNH endonuclease
IOD48_RS00130	COG3179	chitinase
IOD48_RS00285	COG0538	isocitrate dehydrogenase activity
IOD48_RS00290	COG0582	viral genome integration into host DNA
IOD48_RS00360	COG1846	Transcriptional regulator
IOD48_RS00370	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
IOD48_RS00375	COG1403	HNH endonuclease
IOD48_RS00415	COG3179	chitinase
IOD48_RS00580	COG0538	isocitrate dehydrogenase activity
IOD48_RS00585	COG0640	Transcriptional regulator
IOD48_RS00605	COG3813	Protein conserved in bacteria
IOD48_RS00610	COG1063	alcohol dehydrogenase
IOD48_RS00615	COG3729	General stress protein
IOD48_RS00620	COG3685	Protein conserved in bacteria
IOD48_RS00625	COG3685	Protein conserved in bacteria
IOD48_RS00630	COG3546	catalase activity
IOD48_RS00635	COG1271	oxidase subunit
IOD48_RS00640	COG1294	oxidase, subunit
IOD48_RS00670	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IOD48_RS00675	COG0583	DNA-binding transcription factor activity
IOD48_RS00680	COG3706	GGDEF domain
IOD48_RS00685	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IOD48_RS00695	COG1560	Kdo2-lipid A biosynthetic process
IOD48_RS00705	COG3182	Iron-regulated membrane protein
IOD48_RS00725	COG2203	Gaf domain
IOD48_RS00725	COG2199	diguanylate cyclase activity
IOD48_RS00730	COG4974	Belongs to the 'phage' integrase family
IOD48_RS00770	COG0338	D12 class N6 adenine-specific DNA methyltransferase
IOD48_RS00790	COG4695	Portal protein
IOD48_RS00930	COG3042	response to heat
IOD48_RS00935	COG3189	MarR family transcriptional regulator
IOD48_RS00940	COG1683	Conserved Protein
IOD48_RS00945	COG0504	CTP synthase activity
IOD48_RS00950	COG2807	transmembrane transport
IOD48_RS00955	COG2207	Transcriptional regulator
IOD48_RS00965	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IOD48_RS00970	COG0859	PFAM glycosyl transferase family 9
IOD48_RS00980	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IOD48_RS00985	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IOD48_RS00990	COG0583	DNA-binding transcription factor activity
IOD48_RS00995	COG1028	Short-chain dehydrogenase reductase Sdr
IOD48_RS01020	COG0386	Belongs to the glutathione peroxidase family
IOD48_RS01035	COG2766	serine protein kinase
IOD48_RS01040	COG3713	MltA-interacting MipA family protein
IOD48_RS01045	COG0656	L-ascorbic acid biosynthetic process
IOD48_RS01065	COG3139	Protein of unknown function (DUF1315)
IOD48_RS01080	COG1335	isochorismatase
IOD48_RS01085	COG0252	asparaginase activity
IOD48_RS01090	COG0616	signal peptide processing
IOD48_RS01095	COG0778	Nitroreductase
IOD48_RS01105	COG0709	Synthesizes selenophosphate from selenide and ATP
IOD48_RS01110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IOD48_RS01115	COG0604	alcohol dehydrogenase
IOD48_RS01115	COG1028	Short-chain dehydrogenase reductase Sdr
IOD48_RS01115	COG3321	synthase
IOD48_RS01120	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IOD48_RS01125	COG0494	nUDIX hydrolase
IOD48_RS01130	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IOD48_RS01135	COG2897	thiosulfate sulfurtransferase activity
IOD48_RS01140	COG4136	ATPase activity
IOD48_RS01145	COG4135	transport system, permease component
IOD48_RS01150	COG4134	Bacterial extracellular solute-binding protein
IOD48_RS01155	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IOD48_RS01160	COG0398	Pfam SNARE associated Golgi protein
IOD48_RS01165	COG0398	Pfam SNARE associated Golgi protein
IOD48_RS01170	COG0708	Exodeoxyribonuclease III
IOD48_RS01180	COG3138	arginine N-succinyltransferase
IOD48_RS01190	COG3724	N-succinylarginine dihydrolase activity
IOD48_RS01200	COG3678	ATP-independent chaperone mediated protein folding
IOD48_RS01205	COG0322	excinuclease ABC activity
IOD48_RS01215	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IOD48_RS01220	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IOD48_RS01230	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IOD48_RS01235	COG1447	Phosphotransferase system cellobiose-specific component IIA
IOD48_RS01240	COG2169	Transcriptional regulator
IOD48_RS01240	COG1917	Cupin 2, conserved barrel domain protein
IOD48_RS01245	COG1486	melibiose metabolic process
IOD48_RS01255	COG0753	catalase activity
IOD48_RS01265	COG1823	symporter activity
IOD48_RS01270	COG1988	membrane-bound metal-dependent
IOD48_RS01275	COG1028	Short-chain dehydrogenase reductase Sdr
IOD48_RS01280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IOD48_RS01310	COG0727	PFAM Uncharacterised protein family (UPF0153)
IOD48_RS01315	COG3047	cAMP biosynthetic process
IOD48_RS01325	COG4774	siderophore transport
IOD48_RS01360	COG0134	indole-3-glycerol-phosphate synthase activity
IOD48_RS01360	COG0135	phosphoribosylanthranilate isomerase activity
IOD48_RS01365	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IOD48_RS01365	COG0512	Glutamine amidotransferase of anthranilate synthase
IOD48_RS01370	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IOD48_RS01380	COG0009	L-threonylcarbamoyladenylate synthase
IOD48_RS01390	COG0583	DNA-binding transcription factor activity
IOD48_RS01410	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
IOD48_RS01415	COG1028	Short-chain dehydrogenase reductase Sdr
IOD48_RS01425	COG0616	signal peptide processing
IOD48_RS01450	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IOD48_RS01460	COG0671	phosphoesterase, PA-phosphatase related
IOD48_RS01465	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
IOD48_RS01470	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IOD48_RS01480	COG0023	Translation Initiation Factor
IOD48_RS01490	COG1349	DNA-binding transcription factor activity
IOD48_RS01505	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IOD48_RS01505	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IOD48_RS01510	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IOD48_RS01520	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IOD48_RS01535	COG4171	peptide transport system, permease
IOD48_RS01550	COG0702	epimerase
IOD48_RS01565	COG1473	amidohydrolase
IOD48_RS01575	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IOD48_RS01580	COG1842	Phage shock protein A
IOD48_RS01590	COG1983	PspC domain protein
IOD48_RS01600	COG3106	COG3106 Predicted ATPase
IOD48_RS01610	COG0583	DNA-binding transcription factor activity
IOD48_RS01615	COG1486	melibiose metabolic process
IOD48_RS01625	COG3180	Ammonia monooxygenase
IOD48_RS01630	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IOD48_RS01635	COG4948	Mandelate Racemase Muconate Lactonizing
IOD48_RS01640	COG2866	Carboxypeptidase
IOD48_RS01650	COG4166	transmembrane transport
IOD48_RS01680	COG0656	L-ascorbic acid biosynthetic process
IOD48_RS01695	COG0583	DNA-binding transcription factor activity
IOD48_RS01700	COG1028	Short-chain dehydrogenase reductase Sdr
IOD48_RS01705	COG1078	dGTPase activity
IOD48_RS01710	COG0693	protein deglycase activity
IOD48_RS01735	COG2885	chlorophyll binding
IOD48_RS01845	COG1028	Short-chain dehydrogenase reductase Sdr
IOD48_RS01850	COG1309	transcriptional regulator
IOD48_RS01855	COG1028	Short-chain dehydrogenase reductase Sdr
IOD48_RS01875	COG0583	DNA-binding transcription factor activity
IOD48_RS01905	COG0604	alcohol dehydrogenase
IOD48_RS01910	COG0436	Aminotransferase
IOD48_RS01925	COG2011	ABC-type metal ion transport system permease component
IOD48_RS01930	COG1448	Aminotransferase
IOD48_RS01940	COG1522	sequence-specific DNA binding
IOD48_RS01945	COG1113	amino acid transport
IOD48_RS01960	COG0673	inositol 2-dehydrogenase activity
IOD48_RS01965	COG1349	DNA-binding transcription factor activity
IOD48_RS01975	COG0513	Belongs to the DEAD box helicase family
IOD48_RS01985	COG0589	response to stress
IOD48_RS01995	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IOD48_RS02000	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IOD48_RS02000	COG1013	pyruvate-flavodoxin oxidoreductase activity
IOD48_RS02000	COG0674	pyruvate-flavodoxin oxidoreductase activity
IOD48_RS02000	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IOD48_RS02005	COG3042	response to heat
IOD48_RS02010	COG3187	Heat shock protein
IOD48_RS02015	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IOD48_RS02020	COG0586	Pfam SNARE associated Golgi protein
IOD48_RS02025	COG2911	Protein conserved in bacteria
IOD48_RS02035	COG3784	Protein of unknown function (DUF1318)
IOD48_RS02040	COG2207	Transcriptional regulator
IOD48_RS02045	COG1012	belongs to the aldehyde dehydrogenase family
IOD48_RS02060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD48_RS02070	COG1126	abc transporter atp-binding protein
IOD48_RS02075	COG0583	DNA-binding transcription factor activity
IOD48_RS02080	COG2072	flavoprotein involved in K transport
IOD48_RS02095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IOD48_RS02115	COG1012	belongs to the aldehyde dehydrogenase family
IOD48_RS02115	COG2030	dehydratase
IOD48_RS02120	COG3396	Phenylacetate-CoA oxygenase
IOD48_RS02125	COG3460	Phenylacetate-CoA oxygenase
IOD48_RS02130	COG3396	Phenylacetate-CoA oxygenase
IOD48_RS02135	COG2151	metal-sulfur cluster biosynthetic enzyme
IOD48_RS02140	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IOD48_RS02145	COG1024	Enoyl-CoA hydratase
IOD48_RS02150	COG1024	Enoyl-CoA hydratase
IOD48_RS02155	COG1250	3-hydroxyacyl-CoA dehydrogenase
IOD48_RS02160	COG2050	protein possibly involved in aromatic compounds catabolism
IOD48_RS02165	COG0183	Belongs to the thiolase family
IOD48_RS02170	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
IOD48_RS02175	COG3327	negative regulation of DNA-templated transcription, initiation
IOD48_RS02180	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IOD48_RS02195	COG1643	Atp-dependent helicase
IOD48_RS02200	COG4122	O-methyltransferase activity
IOD48_RS02225	COG0583	DNA-binding transcription factor activity
IOD48_RS02230	COG0667	Aldo Keto reductase
IOD48_RS02235	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IOD48_RS02245	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IOD48_RS02250	COG3138	arginine N-succinyltransferase
IOD48_RS02255	COG1012	belongs to the aldehyde dehydrogenase family
IOD48_RS02260	COG3724	N-succinylarginine dihydrolase activity
IOD48_RS02265	COG2988	succinylglutamate desuccinylase activity
IOD48_RS02270	COG1113	amino acid transport
IOD48_RS02275	COG0477	Major facilitator Superfamily
IOD48_RS02280	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IOD48_RS02290	COG1012	belongs to the aldehyde dehydrogenase family
IOD48_RS02295	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IOD48_RS02300	COG0401	homolog of Blt101
IOD48_RS02305	COG5562	phage envelope protein
IOD48_RS02310	COG0425	Belongs to the sulfur carrier protein TusA family
IOD48_RS02315	COG2391	methyltransferase activity
IOD48_RS02340	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IOD48_RS02345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IOD48_RS02345	COG1263	PTS System
IOD48_RS02350	COG1609	Transcriptional regulator
IOD48_RS02355	COG5339	Protein conserved in bacteria
IOD48_RS02360	COG1482	cell wall glycoprotein biosynthetic process
IOD48_RS02365	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IOD48_RS02365	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IOD48_RS02370	COG0114	fumarate hydratase activity
IOD48_RS02380	COG2205	protein histidine kinase activity
IOD48_RS02390	COG0745	RESPONSE REGULATOR receiver
IOD48_RS02395	COG3136	membrane protein required for alginate biosynthesis
IOD48_RS02405	COG0531	amino acid
IOD48_RS02420	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IOD48_RS02425	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IOD48_RS02440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IOD48_RS02455	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IOD48_RS02460	COG1473	amidohydrolase
IOD48_RS02470	COG0583	DNA-binding transcription factor activity
IOD48_RS02475	COG2840	Smr protein MutS2
IOD48_RS02480	COG1414	Transcriptional regulator
IOD48_RS02490	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IOD48_RS02495	COG0183	Belongs to the thiolase family
IOD48_RS02505	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IOD48_RS02510	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IOD48_RS02520	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IOD48_RS02520	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IOD48_RS02540	COG4565	transcriptional regulatory protein
IOD48_RS02545	COG3290	protein histidine kinase activity
IOD48_RS02580	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IOD48_RS02590	COG0679	Auxin Efflux Carrier
IOD48_RS02620	COG0628	permease
IOD48_RS02640	COG3591	Belongs to the peptidase S1B family
IOD48_RS02650	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
IOD48_RS02655	COG2814	Major facilitator Superfamily
IOD48_RS02660	COG0583	DNA-binding transcription factor activity
IOD48_RS02665	COG1940	carbohydrate kinase activity
IOD48_RS02670	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IOD48_RS02685	COG3302	dmso reductase anchor subunit
IOD48_RS02690	COG0437	4 iron, 4 sulfur cluster binding
IOD48_RS02695	COG0243	molybdopterin cofactor binding
IOD48_RS02710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IOD48_RS02725	COG2271	Major facilitator Superfamily
IOD48_RS02730	COG0246	Mannitol dehydrogenase
IOD48_RS02735	COG0589	response to stress
IOD48_RS02740	COG1802	Transcriptional regulator
IOD48_RS02745	COG4221	oxidoreductase activity
IOD48_RS02760	COG2207	Transcriptional regulator
IOD48_RS02765	COG2135	peptidase activity
IOD48_RS02800	COG0071	Belongs to the small heat shock protein (HSP20) family
IOD48_RS02805	COG1546	Belongs to the CinA family
IOD48_RS02810	COG2200	EAL domain
IOD48_RS02825	COG3708	Transcriptional regulator
IOD48_RS02825	COG2207	Transcriptional regulator
IOD48_RS02830	COG2610	gluconate transmembrane transporter activity
IOD48_RS02835	COG3622	Belongs to the hyi family
IOD48_RS02840	COG0235	Class ii aldolase
IOD48_RS02845	COG3395	kinase activity
IOD48_RS02850	COG2084	Dehydrogenase
IOD48_RS02855	COG1349	DNA-binding transcription factor activity
IOD48_RS02870	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IOD48_RS02875	COG2223	nitrite transmembrane transporter activity
IOD48_RS02915	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IOD48_RS02920	COG0683	leucine binding
IOD48_RS02940	COG0410	ABC transporter
IOD48_RS02950	COG2814	Major facilitator Superfamily
IOD48_RS02955	COG0697	spore germination
IOD48_RS02965	COG4977	sequence-specific DNA binding
IOD48_RS02995	COG1028	Short-chain dehydrogenase reductase Sdr
IOD48_RS03000	COG2731	YhcH YjgK YiaL family protein
IOD48_RS03015	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IOD48_RS03025	COG3395	kinase activity
IOD48_RS03030	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IOD48_RS03035	COG1349	DNA-binding transcription factor activity
IOD48_RS03040	COG0039	L-malate dehydrogenase activity
IOD48_RS03050	COG0583	DNA-binding transcription factor activity
IOD48_RS03055	COG1012	belongs to the aldehyde dehydrogenase family
IOD48_RS03070	COG2199	diguanylate cyclase activity
IOD48_RS03120	COG0477	Major facilitator Superfamily
IOD48_RS03130	COG2070	2-Nitropropane dioxygenase
IOD48_RS03135	COG2011	ABC-type metal ion transport system permease component
IOD48_RS03155	COG4628	conserved protein (DUF2132)
IOD48_RS03170	COG2207	Transcriptional regulator
IOD48_RS03200	COG2233	PERMEase
IOD48_RS03205	COG3195	allantoin biosynthetic process
IOD48_RS03205	COG3648	Uricase
IOD48_RS03210	COG2351	hydroxyisourate hydrolase activity
IOD48_RS03215	COG1396	sequence-specific DNA binding
IOD48_RS03220	COG3550	peptidyl-serine autophosphorylation
IOD48_RS03225	COG1649	PFAM Uncharacterised BCR, COG1649
IOD48_RS03235	COG3188	usher protein
IOD48_RS03270	COG5001	Diguanylate cyclase
IOD48_RS03270	COG3300	MHYT domain
IOD48_RS03275	COG2819	hydrolase of the alpha beta superfamily
IOD48_RS03290	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD48_RS03290	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD48_RS03295	COG2814	Major facilitator Superfamily
IOD48_RS03305	COG1263	PTS System
IOD48_RS03305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IOD48_RS03310	COG2186	Transcriptional regulator
IOD48_RS03330	COG3835	regulator
IOD48_RS03335	COG1929	Belongs to the glycerate kinase type-1 family
IOD48_RS03380	COG0738	Major facilitator superfamily
IOD48_RS03385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOD48_RS03390	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IOD48_RS03395	COG1349	DNA-binding transcription factor activity
IOD48_RS03410	COG1349	DNA-binding transcription factor activity
IOD48_RS03415	COG4977	sequence-specific DNA binding
IOD48_RS03435	COG4977	sequence-specific DNA binding
IOD48_RS03460	COG3386	PFAM SMP-30 Gluconolaconase
IOD48_RS03465	COG0667	Aldo Keto reductase
IOD48_RS03470	COG0667	Aldo Keto reductase
IOD48_RS03480	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
IOD48_RS03480	COG0456	acetyltransferase
IOD48_RS03505	COG1652	LysM domain
IOD48_RS03535	COG1609	Transcriptional regulator
IOD48_RS03545	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD48_RS03560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IOD48_RS03575	COG0583	DNA-binding transcription factor activity
IOD48_RS03580	COG0583	DNA-binding transcription factor activity
IOD48_RS03595	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IOD48_RS03595	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IOD48_RS03595	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IOD48_RS03600	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IOD48_RS03610	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IOD48_RS03615	COG3037	sugar-specific permease SgaT UlaA
IOD48_RS03625	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD48_RS03630	COG1609	Transcriptional regulator
IOD48_RS03640	COG2223	nitrite transmembrane transporter activity
IOD48_RS03685	COG0477	Major facilitator Superfamily
IOD48_RS03690	COG4529	Protein conserved in bacteria
IOD48_RS03695	COG1902	pentaerythritol trinitrate reductase activity
IOD48_RS03705	COG0583	DNA-binding transcription factor activity
IOD48_RS03710	COG2070	2-Nitropropane dioxygenase
IOD48_RS03720	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IOD48_RS03730	COG0765	amino acid transport
IOD48_RS03775	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IOD48_RS03795	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IOD48_RS03810	COG2207	Transcriptional regulator
IOD48_RS03825	COG0406	alpha-ribazole phosphatase activity
IOD48_RS03865	COG1953	Uracil, thiamine, allantoin
IOD48_RS03870	COG0402	S-adenosylhomocysteine deaminase activity
IOD48_RS03890	COG3706	GGDEF domain
IOD48_RS03895	COG1609	Transcriptional regulator
IOD48_RS03905	COG0673	inositol 2-dehydrogenase activity
IOD48_RS03920	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IOD48_RS03925	COG1116	anion transmembrane transporter activity
IOD48_RS03930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IOD48_RS03935	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IOD48_RS03940	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IOD48_RS03945	COG0076	glutamate decarboxylase activity
IOD48_RS03960	COG2205	protein histidine kinase activity
IOD48_RS03970	COG0596	Alpha beta hydrolase
IOD48_RS04010	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IOD48_RS04010	COG0519	Catalyzes the synthesis of GMP from XMP
IOD48_RS04030	COG0583	DNA-binding transcription factor activity
IOD48_RS04040	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IOD48_RS04045	COG1285	pathogenesis
IOD48_RS04050	COG2814	Major facilitator Superfamily
IOD48_RS04055	COG1447	Phosphotransferase system cellobiose-specific component IIA
IOD48_RS04060	COG0583	DNA-binding transcription factor activity
IOD48_RS04065	COG0243	molybdopterin cofactor binding
IOD48_RS04070	COG3781	membrane
IOD48_RS04095	COG1764	response to oxidative stress
IOD48_RS04105	COG3111	PFAM Bacterial OB fold (BOF) protein
IOD48_RS04115	COG2323	membrane
IOD48_RS04125	COG0366	Alpha amylase catalytic
IOD48_RS04135	COG3685	Protein conserved in bacteria
IOD48_RS04145	COG3729	General stress protein
IOD48_RS04150	COG1028	Short-chain dehydrogenase reductase Sdr
IOD48_RS04195	COG0488	(ABC) transporter
IOD48_RS04210	COG1064	alcohol dehydrogenase
IOD48_RS04215	COG0747	negative chemotaxis
IOD48_RS04225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOD48_RS04235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD48_RS04245	COG2814	Major facilitator Superfamily
IOD48_RS04255	COG2326	polyphosphate kinase activity
IOD48_RS04270	COG2864	formate dehydrogenase
IOD48_RS04275	COG0437	4 iron, 4 sulfur cluster binding
IOD48_RS04300	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
IOD48_RS04310	COG3485	protocatechuate 3,4-dioxygenase
IOD48_RS04315	COG4829	muconolactone delta-isomerase
IOD48_RS04320	COG4948	Mandelate Racemase Muconate Lactonizing
IOD48_RS04325	COG1414	Transcriptional regulator
IOD48_RS04345	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IOD48_RS04350	COG1140	nitrate reductase beta subunit
IOD48_RS04355	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
IOD48_RS04360	COG2181	nitrate reductase activity
IOD48_RS04365	COG2162	N-hydroxyarylamine O-acetyltransferase activity
IOD48_RS04370	COG1178	ABC-type Fe3 transport system permease component
IOD48_RS04375	COG1840	ABC-type Fe3 transport system, periplasmic component
IOD48_RS04380	COG3842	ATPase activity
IOD48_RS04385	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IOD48_RS04400	COG2211	Major facilitator Superfamily
IOD48_RS04420	COG0625	glutathione transferase activity
IOD48_RS04430	COG1126	abc transporter atp-binding protein
IOD48_RS04435	COG0765	amino acid transport
IOD48_RS04445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD48_RS04450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD48_RS04455	COG1473	amidohydrolase
IOD48_RS04460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD48_RS04465	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IOD48_RS04490	COG4772	TonB-dependent receptor
IOD48_RS04495	COG1228	amidohydrolase
IOD48_RS04500	COG3691	Protein conserved in bacteria
IOD48_RS04515	COG2130	NADP-dependent
IOD48_RS04525	COG1247	-acetyltransferase
IOD48_RS04530	COG3238	Protein conserved in bacteria
IOD48_RS04540	COG0747	negative chemotaxis
IOD48_RS04545	COG1012	belongs to the aldehyde dehydrogenase family
IOD48_RS04580	COG1012	belongs to the aldehyde dehydrogenase family
IOD48_RS04585	COG1177	transmembrane transport
IOD48_RS04590	COG1176	ABC-type spermidine putrescine transport system, permease component I
IOD48_RS04595	COG3842	ATPase activity
IOD48_RS04600	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IOD48_RS04605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOD48_RS04610	COG1271	oxidase subunit
IOD48_RS04615	COG1294	oxidase, subunit
IOD48_RS04635	COG0826	peptidase U32
IOD48_RS04645	COG1396	sequence-specific DNA binding
IOD48_RS04650	COG3135	benzoate transporter
IOD48_RS04655	COG3708	Transcriptional regulator
IOD48_RS04655	COG2207	Transcriptional regulator
IOD48_RS04670	COG0500	methyltransferase
IOD48_RS04675	COG1275	C4-dicarboxylate transporter malic acid transport protein
IOD48_RS04680	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IOD48_RS04685	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IOD48_RS04700	COG2272	Belongs to the type-B carboxylesterase lipase family
IOD48_RS04705	COG5383	Protein conserved in bacteria
IOD48_RS04710	COG3485	protocatechuate 3,4-dioxygenase
IOD48_RS04715	COG3485	protocatechuate 3,4-dioxygenase
IOD48_RS04720	COG0583	DNA-binding transcription factor activity
IOD48_RS04740	COG3038	cytochrome b561
IOD48_RS04760	COG2814	Major facilitator Superfamily
IOD48_RS04770	COG0673	inositol 2-dehydrogenase activity
IOD48_RS04780	COG2723	6-phospho-beta-galactosidase activity
IOD48_RS04815	COG4659	FMN binding
IOD48_RS04825	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IOD48_RS04835	COG0625	glutathione transferase activity
IOD48_RS04840	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IOD48_RS04855	COG3895	Periplasmic Protein
IOD48_RS04870	COG3706	GGDEF domain
IOD48_RS04885	COG1566	PFAM secretion protein HlyD family protein
IOD48_RS04890	COG1289	transmembrane transporter activity
IOD48_RS04895	COG2032	superoxide dismutase activity
IOD48_RS04900	COG4989	oxidoreductase activity
IOD48_RS04905	COG3313	Fe-S protein
IOD48_RS04910	COG1309	transcriptional regulator
IOD48_RS04915	COG1902	pentaerythritol trinitrate reductase activity
IOD48_RS04920	COG0346	lactoylglutathione lyase activity
IOD48_RS04930	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IOD48_RS04935	COG0791	NLP P60 protein
IOD48_RS04950	COG2814	Major facilitator Superfamily
IOD48_RS04965	COG0583	DNA-binding transcription factor activity
IOD48_RS04970	COG2814	Major facilitator Superfamily
IOD48_RS04975	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IOD48_RS04980	COG0307	riboflavin synthase, alpha
IOD48_RS05035	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IOD48_RS05070	COG1349	DNA-binding transcription factor activity
IOD48_RS05075	COG0346	lactoylglutathione lyase activity
IOD48_RS05100	COG0444	Belongs to the ABC transporter superfamily
IOD48_RS05105	COG4608	Belongs to the ABC transporter superfamily
IOD48_RS05135	COG0604	alcohol dehydrogenase
IOD48_RS05135	COG1028	Short-chain dehydrogenase reductase Sdr
IOD48_RS05135	COG3321	synthase
IOD48_RS05175	COG0402	S-adenosylhomocysteine deaminase activity
IOD48_RS05200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IOD48_RS05205	COG0277	FAD linked oxidase domain protein
IOD48_RS05220	COG2814	Major facilitator Superfamily
IOD48_RS05250	COG0583	DNA-binding transcription factor activity
IOD48_RS05260	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IOD48_RS05270	COG1250	3-hydroxyacyl-CoA dehydrogenase
IOD48_RS05275	COG2610	gluconate transmembrane transporter activity
IOD48_RS05280	COG1028	Short-chain dehydrogenase reductase Sdr
IOD48_RS05310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IOD48_RS05325	COG0745	RESPONSE REGULATOR receiver
IOD48_RS05330	COG5002	protein histidine kinase activity
IOD48_RS05330	COG3850	Histidine kinase
IOD48_RS05345	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
IOD48_RS05350	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IOD48_RS05355	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IOD48_RS05360	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IOD48_RS05395	COG4235	cytochrome complex assembly
IOD48_RS05395	COG3088	subunit of a heme lyase
IOD48_RS05400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IOD48_RS05405	COG1138	Cytochrome C-type biogenesis protein
IOD48_RS05420	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IOD48_RS05425	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IOD48_RS05430	COG4133	protoheme IX ABC transporter activity
IOD48_RS05460	COG1175	transmembrane transport
IOD48_RS05470	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IOD48_RS05475	COG3383	formate dehydrogenase (NAD+) activity
IOD48_RS05515	COG1126	abc transporter atp-binding protein
IOD48_RS05520	COG0765	amino acid transport
IOD48_RS05540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOD48_RS05545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOD48_RS05550	COG1120	ATPase activity
IOD48_RS05555	COG4774	siderophore transport
IOD48_RS05560	COG1116	anion transmembrane transporter activity
IOD48_RS05565	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IOD48_RS05585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD48_RS05590	COG0583	DNA-binding transcription factor activity
IOD48_RS05610	COG2814	Major facilitator Superfamily
IOD48_RS05645	COG1414	Transcriptional regulator
IOD48_RS05650	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IOD48_RS05655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOD48_RS05660	COG1120	ATPase activity
IOD48_RS05670	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IOD48_RS05675	COG2271	Major facilitator Superfamily
IOD48_RS05680	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IOD48_RS05680	COG1082	Xylose isomerase domain protein TIM barrel
IOD48_RS05685	COG1309	transcriptional regulator
IOD48_RS05715	COG1376	ErfK ybiS ycfS ynhG family protein
IOD48_RS05730	COG0719	Fe-S assembly protein
IOD48_RS05735	COG0396	ATPase activity
IOD48_RS05740	COG0719	Fe-S assembly protein
IOD48_RS05745	COG0316	Belongs to the HesB IscA family
IOD48_RS05765	COG1309	transcriptional regulator
IOD48_RS05770	COG1304	FMN binding
IOD48_RS05795	COG0583	DNA-binding transcription factor activity
IOD48_RS05805	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOD48_RS05810	COG1120	ATPase activity
IOD48_RS05835	COG2261	transglycosylase associated protein
IOD48_RS05840	COG2050	protein possibly involved in aromatic compounds catabolism
IOD48_RS05845	COG0247	lactate metabolic process
IOD48_RS05845	COG0277	FAD linked oxidase domain protein
IOD48_RS05850	COG0628	permease
IOD48_RS05860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IOD48_RS05860	COG0574	Belongs to the PEP-utilizing enzyme family
IOD48_RS05875	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IOD48_RS05880	COG4256	Hemin uptake protein
IOD48_RS05890	COG0791	NLP P60 protein
IOD48_RS05900	COG0386	Belongs to the glutathione peroxidase family
IOD48_RS05920	COG0583	DNA-binding transcription factor activity
IOD48_RS05940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IOD48_RS05940	COG0072	phenylalanine-tRNA ligase activity
IOD48_RS05980	COG3137	Salt-induced outer membrane protein
IOD48_RS05985	COG1105	Belongs to the carbohydrate kinase PfkB family
IOD48_RS05995	COG3001	Fructosamine kinase
IOD48_RS06005	COG2350	Protein conserved in bacteria
IOD48_RS06015	COG2353	YceI-like domain
IOD48_RS06035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IOD48_RS06045	COG0444	Belongs to the ABC transporter superfamily
IOD48_RS06050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOD48_RS06055	COG0601	transmembrane transport
IOD48_RS06060	COG4166	transmembrane transport
IOD48_RS06065	COG2095	MarC family integral membrane protein
IOD48_RS06075	COG1454	alcohol dehydrogenase
IOD48_RS06075	COG1012	belongs to the aldehyde dehydrogenase family
IOD48_RS06080	COG1435	thymidine kinase activity
IOD48_RS06090	COG2916	Histone family protein nucleoid-structuring protein H-NS
IOD48_RS06095	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IOD48_RS06100	COG0745	RESPONSE REGULATOR receiver
IOD48_RS06105	COG1752	Esterase of the alpha-beta hydrolase superfamily
IOD48_RS06115	COG0788	formyltetrahydrofolate deformylase activity
IOD48_RS06150	COG1522	sequence-specific DNA binding
IOD48_RS06160	COG2181	nitrate reductase activity
IOD48_RS06165	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
IOD48_RS06170	COG1140	nitrate reductase beta subunit
IOD48_RS06175	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IOD48_RS06185	COG2223	nitrite transmembrane transporter activity
IOD48_RS06190	COG3850	Histidine kinase
IOD48_RS06195	COG2197	response regulator
IOD48_RS06200	COG4932	domain protein
IOD48_RS06205	COG0243	molybdopterin cofactor binding
IOD48_RS06210	COG2146	nitrite reductase [NAD(P)H] activity
IOD48_RS06210	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IOD48_RS06215	COG1116	anion transmembrane transporter activity
IOD48_RS06220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IOD48_RS06225	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IOD48_RS06230	COG3707	response regulator
IOD48_RS06235	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
IOD48_RS06245	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
IOD48_RS06250	COG4572	Cation transport regulator
IOD48_RS06255	COG0387	Pfam Sodium calcium exchanger
IOD48_RS06275	COG2890	protein-(glutamine-N5) methyltransferase activity
IOD48_RS06305	COG0659	secondary active sulfate transmembrane transporter activity
IOD48_RS06325	COG0012	GTP binding
IOD48_RS06415	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IOD48_RS06495	COG2885	chlorophyll binding
IOD48_RS06515	COG3122	Protein conserved in bacteria
IOD48_RS06530	COG0583	DNA-binding transcription factor activity
IOD48_RS06560	COG0583	DNA-binding transcription factor activity
IOD48_RS06595	COG1882	Formate acetyltransferase
IOD48_RS06610	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IOD48_RS06615	COG0583	DNA-binding transcription factor activity
IOD48_RS06655	COG2308	Evidence 4 Homologs of previously reported genes of
IOD48_RS06670	COG4774	siderophore transport
IOD48_RS06680	COG1619	proteins homologs of microcin C7 resistance protein MccF
IOD48_RS06705	COG2719	SpoVR family
IOD48_RS06735	COG0179	Fumarylacetoacetate (FAA) hydrolase
IOD48_RS06750	COG2894	cell division
IOD48_RS06760	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IOD48_RS06770	COG3065	identical protein binding
IOD48_RS06780	COG1199	ATP-dependent helicase activity
IOD48_RS06785	COG0251	oxidation-reduction process
IOD48_RS06805	COG1760	l-serine dehydratase
IOD48_RS06810	COG2200	EAL domain
IOD48_RS06815	COG1253	flavin adenine dinucleotide binding
IOD48_RS06820	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD48_RS06820	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IOD48_RS06825	COG3715	PTS system
IOD48_RS06830	COG3716	PTS system mannose fructose sorbose family IID component
IOD48_RS06845	COG2226	methyltransferase
IOD48_RS06850	COG0768	penicillin binding
IOD48_RS06880	COG1414	Transcriptional regulator
IOD48_RS06885	COG2814	Major facilitator Superfamily
IOD48_RS06905	COG1956	GAF domain-containing protein
IOD48_RS06910	COG2995	paraquat-inducible protein a
IOD48_RS06915	COG3008	intermembrane lipid transfer
IOD48_RS06940	COG2990	Protein conserved in bacteria
IOD48_RS06955	COG1276	copper resistance
IOD48_RS06960	COG2372	response to copper ion
IOD48_RS06970	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IOD48_RS06975	COG1770	oligopeptidase
IOD48_RS06980	COG2979	Protein of unknown function (DUF533)
IOD48_RS06985	COG3141	response to X-ray
IOD48_RS06995	COG0800	Aldolase
IOD48_RS07000	COG0129	dihydroxy-acid dehydratase activity
IOD48_RS07005	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IOD48_RS07015	COG1737	Transcriptional regulator
IOD48_RS07025	COG1560	Kdo2-lipid A biosynthetic process
IOD48_RS07030	COG0739	heme binding
IOD48_RS07035	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
IOD48_RS07045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IOD48_RS07070	COG0494	nUDIX hydrolase
IOD48_RS07080	COG1335	isochorismatase
IOD48_RS07085	COG1801	Protein of unknown function DUF72
IOD48_RS07090	COG3788	relative of glutathione S-transferase, MAPEG superfamily
IOD48_RS07110	COG3102	Protein conserved in bacteria
IOD48_RS07120	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
IOD48_RS07145	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD48_RS07155	COG1879	ABC-type sugar transport system periplasmic component
IOD48_RS07165	COG1528	Iron-storage protein
IOD48_RS07175	COG2211	Major facilitator Superfamily
IOD48_RS07185	COG0477	Major facilitator Superfamily
IOD48_RS07200	COG1528	Iron-storage protein
IOD48_RS07210	COG0814	amino acid
IOD48_RS07215	COG3318	Belongs to the UPF0149 family
IOD48_RS07215	COG3012	SEC-C Motif Domain Protein
IOD48_RS07250	COG2197	response regulator
IOD48_RS07260	COG2197	response regulator
IOD48_RS07265	COG1126	abc transporter atp-binding protein
IOD48_RS07270	COG0765	amino acid transport
IOD48_RS07280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD48_RS07285	COG0366	Alpha amylase catalytic
IOD48_RS07315	COG2354	Protein conserved in bacteria
IOD48_RS07320	COG0697	spore germination
IOD48_RS07325	COG3727	T/G mismatch-specific endonuclease activity
IOD48_RS07330	COG0270	DNA (cytosine-5-)-methyltransferase activity
IOD48_RS07335	COG1418	mRNA catabolic process
IOD48_RS07345	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IOD48_RS07395	COG0025	NhaP-type Na H and K H
IOD48_RS07400	COG1309	transcriptional regulator
IOD48_RS07405	COG0604	alcohol dehydrogenase
IOD48_RS07425	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IOD48_RS07435	COG0534	Mate efflux family protein
IOD48_RS07450	COG3706	GGDEF domain
IOD48_RS07475	COG3615	Tellurite resistance protein tehB
IOD48_RS07485	COG3300	MHYT domain
IOD48_RS07485	COG5001	Diguanylate cyclase
IOD48_RS07495	COG0477	Major facilitator Superfamily
IOD48_RS07500	COG0095	Lipoate-protein ligase
IOD48_RS07505	COG0583	DNA-binding transcription factor activity
IOD48_RS07510	COG1942	4-Oxalocrotonate Tautomerase
IOD48_RS07520	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IOD48_RS07540	COG1289	transmembrane transporter activity
IOD48_RS07555	COG2925	Exonuclease
IOD48_RS07560	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IOD48_RS07565	COG0640	Transcriptional regulator
IOD48_RS07570	COG0531	amino acid
IOD48_RS07580	COG0583	DNA-binding transcription factor activity
IOD48_RS07585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IOD48_RS07615	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IOD48_RS07640	COG0463	Glycosyl transferase, family 2
IOD48_RS07655	COG0438	transferase activity, transferring glycosyl groups
IOD48_RS07725	COG0463	Glycosyl transferase, family 2
IOD48_RS07745	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IOD48_RS07805	COG1253	flavin adenine dinucleotide binding
IOD48_RS07810	COG2982	Protein involved in outer membrane biogenesis
IOD48_RS07825	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IOD48_RS07830	COG0443	Heat shock 70 kDa protein
IOD48_RS07835	COG5002	protein histidine kinase activity
IOD48_RS07855	COG1301	dicarboxylic acid transport
IOD48_RS07880	COG2205	protein histidine kinase activity
IOD48_RS07885	COG0745	RESPONSE REGULATOR receiver
IOD48_RS07890	COG0826	peptidase U32
IOD48_RS07900	COG4608	Belongs to the ABC transporter superfamily
IOD48_RS07905	COG0444	Belongs to the ABC transporter superfamily
IOD48_RS07910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOD48_RS07915	COG0601	transmembrane transport
IOD48_RS07920	COG0747	negative chemotaxis
IOD48_RS07925	COG4948	Mandelate Racemase Muconate Lactonizing
IOD48_RS07930	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IOD48_RS07940	COG1070	Carbohydrate kinase
IOD48_RS07965	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IOD48_RS07975	COG1830	Aldolase
IOD48_RS07980	COG0351	phosphomethylpyrimidine kinase
IOD48_RS07995	COG0583	DNA-binding transcription factor activity
IOD48_RS08005	COG2252	PERMEase
IOD48_RS08010	COG0583	DNA-binding transcription factor activity
IOD48_RS08015	COG5455	response to cobalt ion
IOD48_RS08035	COG4807	Protein conserved in bacteria
IOD48_RS08045	COG3275	phosphorelay sensor kinase activity
IOD48_RS08055	COG1174	glycine betaine transport
IOD48_RS08060	COG1125	glycine betaine transport
IOD48_RS08065	COG1174	glycine betaine transport
IOD48_RS08070	COG1732	Glycine betaine
IOD48_RS08075	COG1472	Belongs to the glycosyl hydrolase 3 family
IOD48_RS08080	COG0277	FAD linked oxidase domain protein
IOD48_RS08090	COG1686	Belongs to the peptidase S11 family
IOD48_RS08100	COG0586	Pfam SNARE associated Golgi protein
IOD48_RS08105	COG1538	Outer membrane efflux protein
IOD48_RS08110	COG2723	6-phospho-beta-galactosidase activity
IOD48_RS08125	COG3659	wide pore channel activity
IOD48_RS08130	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IOD48_RS08140	COG1346	cytolysis
IOD48_RS08150	COG2949	membrane
IOD48_RS08160	COG1129	ABC transporter
IOD48_RS08175	COG2311	Membrane
IOD48_RS08190	COG4771	TonB-dependent receptor
IOD48_RS08195	COG0833	amino acid
IOD48_RS08200	COG0583	DNA-binding transcription factor activity
IOD48_RS08205	COG2855	membrane
IOD48_RS08215	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IOD48_RS08215	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IOD48_RS08215	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IOD48_RS08220	COG1105	Belongs to the carbohydrate kinase PfkB family
IOD48_RS08225	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD48_RS08225	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD48_RS08250	COG1312	Catalyzes the dehydration of D-mannonate
IOD48_RS08255	COG0246	Mannitol dehydrogenase
IOD48_RS08260	COG0523	cobalamin synthesis protein
IOD48_RS08265	COG0671	phosphoesterase, PA-phosphatase related
IOD48_RS08270	COG0791	NLP P60 protein
IOD48_RS08275	COG2200	EAL domain
IOD48_RS08280	COG4166	transmembrane transport
IOD48_RS08285	COG4174	ABC transporter (Permease)
IOD48_RS08290	COG4239	(ABC) transporter, permease
IOD48_RS08295	COG4172	Belongs to the ABC transporter superfamily
IOD48_RS08305	COG2814	Major facilitator Superfamily
IOD48_RS08310	COG1187	pseudouridine synthase activity
IOD48_RS08315	COG1061	Type III restriction enzyme res subunit
IOD48_RS08335	COG0494	nUDIX hydrolase
IOD48_RS08340	COG1349	DNA-binding transcription factor activity
IOD48_RS08365	COG0628	permease
IOD48_RS08380	COG0659	secondary active sulfate transmembrane transporter activity
IOD48_RS08385	COG2239	Acts as a magnesium transporter
IOD48_RS08390	COG4615	Cyclic peptide transporter
IOD48_RS08395	COG3145	DNA-N1-methyladenine dioxygenase activity
IOD48_RS08400	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IOD48_RS08400	COG2169	Transcriptional regulator
IOD48_RS08415	COG2198	Histidine kinase
IOD48_RS08415	COG0642	Histidine kinase
IOD48_RS08425	COG2205	protein histidine kinase activity
IOD48_RS08425	COG0784	Response regulator, receiver
IOD48_RS08450	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IOD48_RS08455	COG0584	glycerophosphoryl diester phosphodiesterase
IOD48_RS08460	COG2271	Major facilitator Superfamily
IOD48_RS08465	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IOD48_RS08475	COG0247	lactate metabolic process
IOD48_RS08485	COG2271	Major facilitator Superfamily
IOD48_RS08495	COG1414	Transcriptional regulator
IOD48_RS08510	COG5464	transposase or invertase
IOD48_RS08520	COG0318	PFAM AMP-dependent synthetase and ligase
IOD48_RS08545	COG1169	isochorismate synthase
IOD48_RS08550	COG2153	protein acetylation
IOD48_RS08565	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IOD48_RS08570	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IOD48_RS08580	COG0839	Belongs to the complex I subunit 6 family
IOD48_RS08625	COG0583	DNA-binding transcription factor activity
IOD48_RS08630	COG0436	Aminotransferase
IOD48_RS08640	COG0490	domain, Protein
IOD48_RS08640	COG0471	metal ion transport
IOD48_RS08645	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IOD48_RS08665	COG0280	phosphate acetyltransferase
IOD48_RS08665	COG0857	belongs to the CobB CobQ family
IOD48_RS08670	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IOD48_RS08675	COG0622	Phosphoesterase
IOD48_RS08680	COG0625	glutathione transferase activity
IOD48_RS08685	COG0625	glutathione transferase activity
IOD48_RS08690	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IOD48_RS08695	COG1090	epimerase
IOD48_RS08710	COG4598	ABC transporter
IOD48_RS08715	COG4160	amino acid transport
IOD48_RS08740	COG0163	prenyltransferase activity
IOD48_RS08745	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IOD48_RS08750	COG1286	toxin biosynthetic process
IOD48_RS08755	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
IOD48_RS08760	COG0285	dihydrofolate synthase activity
IOD48_RS08770	COG0586	Pfam SNARE associated Golgi protein
IOD48_RS08780	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IOD48_RS08800	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IOD48_RS08815	COG3101	peptidyl-lysine hydroxylation
IOD48_RS08820	COG0730	response to heat
IOD48_RS08845	COG2062	phosphohistidine phosphatase, SixA
IOD48_RS08860	COG3691	Protein conserved in bacteria
IOD48_RS08870	COG2853	Lipoprotein
IOD48_RS08875	COG2116	formate transmembrane transporter activity
IOD48_RS08895	COG0583	DNA-binding transcription factor activity
IOD48_RS08900	COG0590	tRNA wobble adenosine to inosine editing
IOD48_RS08905	COG2807	transmembrane transport
IOD48_RS08915	COG0436	Aminotransferase
IOD48_RS08930	COG3275	phosphorelay sensor kinase activity
IOD48_RS08935	COG3279	Response regulator of the LytR AlgR family
IOD48_RS08950	COG3961	Belongs to the TPP enzyme family
IOD48_RS08955	COG0667	Aldo Keto reductase
IOD48_RS08970	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IOD48_RS08975	COG2200	EAL domain
IOD48_RS08975	COG2199	diguanylate cyclase activity
IOD48_RS08990	COG3415	Transposase
IOD48_RS08995	COG3415	Transposase
IOD48_RS09025	COG0583	DNA-binding transcription factor activity
IOD48_RS09030	COG0385	Bile acid
IOD48_RS09035	COG3530	Putative quorum-sensing-regulated virulence factor
IOD48_RS09055	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IOD48_RS09090	COG4319	ketosteroid isomerase
IOD48_RS09100	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IOD48_RS09105	COG4208	sulfate ABC transporter
IOD48_RS09110	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IOD48_RS09115	COG4150	thiosulfate binding
IOD48_RS09125	COG2837	iron assimilation
IOD48_RS09145	COG0860	N-Acetylmuramoyl-L-alanine amidase
IOD48_RS09235	COG4810	utilization protein
IOD48_RS09245	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IOD48_RS09250	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IOD48_RS09255	COG5342	invasion associated locus B
IOD48_RS09265	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IOD48_RS09265	COG0493	'glutamate synthase
IOD48_RS09270	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IOD48_RS09280	COG1393	Belongs to the ArsC family
IOD48_RS09295	COG0400	carboxylic ester hydrolase activity
IOD48_RS09300	COG1444	tRNA N-acetyltransferase activity
IOD48_RS09305	COG2321	neutral zinc metallopeptidase
IOD48_RS09315	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
IOD48_RS09325	COG2716	regulation of RNA biosynthetic process
IOD48_RS09330	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IOD48_RS09335	COG0628	permease
IOD48_RS09345	COG4783	chaperone-mediated protein folding
IOD48_RS09350	COG1393	Belongs to the ArsC family
IOD48_RS09365	COG2233	PERMEase
IOD48_RS09375	COG2723	6-phospho-beta-galactosidase activity
IOD48_RS09390	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IOD48_RS09405	COG2200	EAL domain
IOD48_RS09425	COG0641	radical SAM
IOD48_RS09430	COG3119	arylsulfatase activity
IOD48_RS09440	COG0517	IMP dehydrogenase activity
IOD48_RS09440	COG0516	GMP reductase activity
IOD48_RS09450	COG1645	bacterial-type flagellum-dependent swarming motility
IOD48_RS09470	COG2976	Protein conserved in bacteria
IOD48_RS09500	COG4953	penicillin-binding protein 1C
IOD48_RS09505	COG2373	Large extracellular alpha-helical protein
IOD48_RS09510	COG2897	thiosulfate sulfurtransferase activity
IOD48_RS09530	COG2975	iron-sulfur cluster assembly
IOD48_RS09535	COG0633	Ferredoxin
IOD48_RS09555	COG0822	iron-sulfur transferase activity
IOD48_RS09585	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
IOD48_RS09590	COG3683	transport system, periplasmic component
IOD48_RS09595	COG3711	transcriptional antiterminator
IOD48_RS09600	COG2814	Major facilitator Superfamily
IOD48_RS09605	COG2017	converts alpha-aldose to the beta-anomer
IOD48_RS09610	COG0477	Major facilitator Superfamily
IOD48_RS09610	COG2814	Major facilitator Superfamily
IOD48_RS09615	COG0457	Tetratricopeptide repeat
IOD48_RS09620	COG1940	carbohydrate kinase activity
IOD48_RS09625	COG2259	Doxx family
IOD48_RS09635	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IOD48_RS09635	COG1017	nitric oxide dioxygenase activity
IOD48_RS09640	COG0347	Belongs to the P(II) protein family
IOD48_RS09645	COG2204	response regulator
IOD48_RS09650	COG3170	Tfp pilus assembly protein FimV
IOD48_RS09655	COG2205	protein histidine kinase activity
IOD48_RS09660	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IOD48_RS09660	COG0047	phosphoribosylformylglycinamidine synthase activity
IOD48_RS09675	COG0560	Phosphoserine phosphatase
IOD48_RS09680	COG1737	Transcriptional regulator
IOD48_RS09685	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IOD48_RS09695	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IOD48_RS09715	COG0681	Belongs to the peptidase S26 family
IOD48_RS09725	COG3086	response to oxidative stress
IOD48_RS09730	COG3026	antisigma factor binding
IOD48_RS09735	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
IOD48_RS09750	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IOD48_RS09760	COG0513	Belongs to the DEAD box helicase family
IOD48_RS09775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IOD48_RS09780	COG3118	belongs to the thioredoxin family
IOD48_RS09785	COG3148	PFAM DTW domain containing protein
IOD48_RS09795	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IOD48_RS09800	COG5544	Lipoprotein
IOD48_RS09805	COG0477	Major facilitator Superfamily
IOD48_RS09830	COG0542	response to heat
IOD48_RS09845	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IOD48_RS09850	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IOD48_RS09860	COG1605	Chorismate mutase
IOD48_RS09860	COG0077	Prephenate dehydratase
IOD48_RS09870	COG0287	Prephenate dehydrogenase
IOD48_RS09870	COG1605	Chorismate mutase
IOD48_RS09875	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IOD48_RS09885	COG2199	diguanylate cyclase activity
IOD48_RS09890	COG2885	chlorophyll binding
IOD48_RS09925	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IOD48_RS09930	COG4137	Cytochrome C assembly protein
IOD48_RS09935	COG4536	flavin adenine dinucleotide binding
IOD48_RS09950	COG0497	DNA recombination
IOD48_RS09965	COG2867	negative regulation of translational initiation
IOD48_RS09980	COG0582	viral genome integration into host DNA
IOD48_RS10050	COG2207	Transcriptional regulator
IOD48_RS10050	COG3708	Transcriptional regulator
IOD48_RS10055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOD48_RS10090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD48_RS10100	COG0235	Class ii aldolase
IOD48_RS10110	COG1028	Short-chain dehydrogenase reductase Sdr
IOD48_RS10125	COG2197	response regulator
IOD48_RS10130	COG3539	Fimbrial protein
IOD48_RS10140	COG3188	usher protein
IOD48_RS10160	COG3121	Chaperone
IOD48_RS10165	COG3539	Fimbrial protein
IOD48_RS10175	COG3284	Transcriptional regulator
IOD48_RS10180	COG0583	DNA-binding transcription factor activity
IOD48_RS10190	COG0640	Transcriptional regulator
IOD48_RS10195	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IOD48_RS10210	COG2916	Histone family protein nucleoid-structuring protein H-NS
IOD48_RS10225	COG4575	ribosome binding
IOD48_RS10230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOD48_RS10235	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IOD48_RS10240	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IOD48_RS10250	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IOD48_RS10265	COG4176	ABC-type proline glycine betaine transport system permease component
IOD48_RS10275	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IOD48_RS10285	COG1846	Transcriptional regulator
IOD48_RS10290	COG1566	PFAM secretion protein HlyD family protein
IOD48_RS10295	COG2814	Major facilitator Superfamily
IOD48_RS10300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IOD48_RS10320	COG1238	metal cluster binding
IOD48_RS10325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IOD48_RS10330	COG2823	Periplasmic or secreted lipoprotein
IOD48_RS10360	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IOD48_RS10380	COG1546	Belongs to the CinA family
IOD48_RS10385	COG0803	Belongs to the bacterial solute-binding protein 9 family
IOD48_RS10390	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IOD48_RS10395	COG1121	(ABC) transporter
IOD48_RS10400	COG2951	lytic endotransglycosylase activity
IOD48_RS10405	COG3730	PTS system glucitol sorbitol-specific
IOD48_RS10410	COG3732	PTS system glucitol sorbitol-specific
IOD48_RS10420	COG1028	Short-chain dehydrogenase reductase Sdr
IOD48_RS10425	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD48_RS10430	COG1349	DNA-binding transcription factor activity
IOD48_RS10455	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
IOD48_RS10460	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
IOD48_RS10465	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IOD48_RS10470	COG1609	Transcriptional regulator
IOD48_RS10475	COG1263	PTS System
IOD48_RS10475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IOD48_RS10480	COG2723	6-phospho-beta-galactosidase activity
IOD48_RS10490	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
IOD48_RS10500	COG3260	NADH ubiquinone oxidoreductase 20
IOD48_RS10505	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IOD48_RS10510	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
IOD48_RS10510	COG3261	NADH dehydrogenase
IOD48_RS10515	COG0650	Formate hydrogenlyase subunit 4
IOD48_RS10520	COG0651	ATP synthesis coupled electron transport
IOD48_RS10525	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IOD48_RS10540	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IOD48_RS10545	COG0298	carbon dioxide binding
IOD48_RS10550	COG0409	Hydrogenase expression formation protein
IOD48_RS10555	COG0309	Hydrogenase expression formation protein (HypE)
IOD48_RS10565	COG2723	6-phospho-beta-galactosidase activity
IOD48_RS10575	COG4580	involved in the transport of maltose and maltodextrins
IOD48_RS10580	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IOD48_RS10585	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IOD48_RS10590	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IOD48_RS10595	COG1447	Phosphotransferase system cellobiose-specific component IIA
IOD48_RS10600	COG1940	carbohydrate kinase activity
IOD48_RS10605	COG1609	Transcriptional regulator
IOD48_RS10610	COG0803	Belongs to the bacterial solute-binding protein 9 family
IOD48_RS10615	COG1121	(ABC) transporter
IOD48_RS10620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IOD48_RS10625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IOD48_RS10640	COG0679	Auxin Efflux Carrier
IOD48_RS10660	COG3720	iron ion transport
IOD48_RS10665	COG4558	Periplasmic binding protein
IOD48_RS10670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOD48_RS10710	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IOD48_RS10715	COG0163	prenyltransferase activity
IOD48_RS10740	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IOD48_RS10745	COG1388	LysM domain
IOD48_RS10745	COG4942	peptidase
IOD48_RS10805	COG2234	aminopeptidase activity
IOD48_RS10825	COG0720	synthase
IOD48_RS10830	COG0602	queuosine metabolic process
IOD48_RS10850	COG3956	TIGRFAM MazG family protein
IOD48_RS10855	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IOD48_RS10865	COG3850	Histidine kinase
IOD48_RS10865	COG3437	response regulator, receiver
IOD48_RS10865	COG2205	protein histidine kinase activity
IOD48_RS10865	COG4999	Histidine kinase
IOD48_RS10870	COG1929	Belongs to the glycerate kinase type-1 family
IOD48_RS10875	COG4948	Mandelate Racemase Muconate Lactonizing
IOD48_RS10880	COG4948	Mandelate Racemase Muconate Lactonizing
IOD48_RS10885	COG2271	Major facilitator Superfamily
IOD48_RS10890	COG0716	FMN binding
IOD48_RS10895	COG0564	pseudouridine synthase activity
IOD48_RS10900	COG3098	single-species biofilm formation
IOD48_RS10915	COG1611	Belongs to the LOG family
IOD48_RS10920	COG0814	amino acid
IOD48_RS10925	COG1760	l-serine dehydratase
IOD48_RS10930	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IOD48_RS10940	COG0477	Major facilitator Superfamily
IOD48_RS10945	COG1464	Belongs to the NlpA lipoprotein family
IOD48_RS10950	COG2011	ABC-type metal ion transport system permease component
IOD48_RS10955	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IOD48_RS10970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD48_RS10990	COG1454	alcohol dehydrogenase
IOD48_RS10995	COG0235	Class ii aldolase
IOD48_RS11000	COG0738	Major facilitator superfamily
IOD48_RS11020	COG1349	DNA-binding transcription factor activity
IOD48_RS11030	COG2363	Small membrane protein
IOD48_RS11035	COG0583	DNA-binding transcription factor activity
IOD48_RS11045	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IOD48_RS11050	COG2166	iron-sulfur cluster assembly
IOD48_RS11055	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IOD48_RS11060	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
IOD48_RS11225	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
IOD48_RS11255	COG1454	alcohol dehydrogenase
IOD48_RS11255	COG1012	belongs to the aldehyde dehydrogenase family
IOD48_RS11260	COG4656	Part of a membrane complex involved in electron transport
IOD48_RS11290	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IOD48_RS11295	COG0860	N-Acetylmuramoyl-L-alanine amidase
IOD48_RS11300	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IOD48_RS11300	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IOD48_RS11310	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IOD48_RS11315	COG1074	ATP-dependent DNA helicase activity
IOD48_RS11320	COG1025	Belongs to the peptidase M16 family
IOD48_RS11325	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IOD48_RS11330	COG4967	type IV pilus modification protein PilV
IOD48_RS11340	COG4795	General secretion pathway protein
IOD48_RS11345	COG2165	general secretion pathway protein
IOD48_RS11380	COG0861	Integral membrane protein TerC family
IOD48_RS11390	COG0667	Aldo Keto reductase
IOD48_RS11410	COG1609	Transcriptional regulator
IOD48_RS11420	COG2186	Transcriptional regulator
IOD48_RS11425	COG2723	6-phospho-beta-galactosidase activity
IOD48_RS11430	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IOD48_RS11435	COG1609	Transcriptional regulator
IOD48_RS11445	COG0583	DNA-binding transcription factor activity
IOD48_RS11450	COG1794	racemase activity, acting on amino acids and derivatives
IOD48_RS11455	COG1917	Cupin 2, conserved barrel domain protein
IOD48_RS11460	COG1175	transmembrane transport
IOD48_RS11465	COG0395	ABC-type sugar transport system, permease component
IOD48_RS11470	COG3842	ATPase activity
IOD48_RS11505	COG2814	Major facilitator Superfamily
IOD48_RS11510	COG1028	Short-chain dehydrogenase reductase Sdr
IOD48_RS11515	COG0823	Involved in the tonB-independent uptake of proteins
IOD48_RS11525	COG0183	Belongs to the thiolase family
IOD48_RS11540	COG0814	amino acid
IOD48_RS11545	COG0667	Aldo Keto reductase
IOD48_RS11595	COG0697	spore germination
IOD48_RS11600	COG1846	Transcriptional regulator
IOD48_RS11605	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
IOD48_RS11610	COG0582	viral genome integration into host DNA
IOD48_RS11615	COG4974	Belongs to the 'phage' integrase family
IOD48_RS11625	COG3539	Fimbrial protein
IOD48_RS11630	COG3121	Chaperone
IOD48_RS11635	COG3188	usher protein
IOD48_RS11640	COG3539	Fimbrial protein
IOD48_RS11645	COG3539	Fimbrial protein
IOD48_RS11650	COG3539	Fimbrial protein
IOD48_RS11660	COG2388	GCN5-related N-acetyl-transferase
IOD48_RS11665	COG3592	Divergent 4Fe-4S mono-cluster
IOD48_RS11680	COG1289	transmembrane transporter activity
IOD48_RS11685	COG1538	Outer membrane efflux protein
IOD48_RS11700	COG1393	Belongs to the ArsC family
IOD48_RS11705	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IOD48_RS11740	COG0667	Aldo Keto reductase
IOD48_RS11755	COG2814	Major facilitator Superfamily
IOD48_RS11765	COG4942	peptidase
IOD48_RS11785	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IOD48_RS11795	COG4974	Belongs to the 'phage' integrase family
IOD48_RS11800	COG0716	FMN binding
IOD48_RS11810	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IOD48_RS11820	COG1272	protein, Hemolysin III
IOD48_RS11830	COG1737	Transcriptional regulator
IOD48_RS11835	COG2723	6-phospho-beta-galactosidase activity
IOD48_RS11855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IOD48_RS11860	COG1028	Short-chain dehydrogenase reductase Sdr
IOD48_RS11880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOD48_RS11885	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOD48_RS11890	COG0006	proline dipeptidase activity
IOD48_RS11910	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IOD48_RS11915	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IOD48_RS11930	COG2968	Membrane
IOD48_RS11940	COG0668	transmembrane transport
IOD48_RS11945	COG0191	fructose-bisphosphate aldolase activity
IOD48_RS11960	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IOD48_RS11965	COG0501	Belongs to the peptidase M48B family
IOD48_RS11985	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
IOD48_RS11990	COG1028	Short-chain dehydrogenase reductase Sdr
IOD48_RS12020	COG1414	Transcriptional regulator
IOD48_RS12025	COG1028	Short-chain dehydrogenase reductase Sdr
IOD48_RS12040	COG2146	nitrite reductase [NAD(P)H] activity
IOD48_RS12075	COG2814	Major facilitator Superfamily
IOD48_RS12085	COG2356	endonuclease I
IOD48_RS12090	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IOD48_RS12095	COG0189	ligase activity
IOD48_RS12115	COG2805	Type II/IV secretion system protein
IOD48_RS12120	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IOD48_RS12125	COG0762	integral membrane protein
IOD48_RS12140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IOD48_RS12150	COG3171	Protein conserved in bacteria
IOD48_RS12160	COG1194	a g-specific adenine glycosylase
IOD48_RS12175	COG2211	Major facilitator Superfamily
IOD48_RS12180	COG1982	Orn Lys Arg decarboxylase major
IOD48_RS12185	COG1811	Na channel or pump
IOD48_RS12220	COG0626	cystathionine gamma-synthase activity
IOD48_RS12225	COG0583	DNA-binding transcription factor activity
IOD48_RS12245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOD48_RS12250	COG0754	glutathionylspermidine amidase activity
IOD48_RS12265	COG0625	glutathione transferase activity
IOD48_RS12290	COG2211	Major facilitator Superfamily
IOD48_RS12295	COG0848	biopolymer transport protein
IOD48_RS12305	COG0626	cystathionine gamma-synthase activity
IOD48_RS12310	COG0586	Pfam SNARE associated Golgi protein
IOD48_RS12315	COG2207	Transcriptional regulator
IOD48_RS12320	COG1979	alcohol dehydrogenase
IOD48_RS12325	COG0656	L-ascorbic acid biosynthetic process
IOD48_RS12335	COG1032	radical SAM domain protein
IOD48_RS12340	COG2132	Multicopper oxidase
IOD48_RS12345	COG0204	Acyl-transferase
IOD48_RS12350	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IOD48_RS12355	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
IOD48_RS12360	COG3111	PFAM Bacterial OB fold (BOF) protein
IOD48_RS12370	COG0642	Histidine kinase
IOD48_RS12375	COG2249	NAD(P)H dehydrogenase (quinone) activity
IOD48_RS12380	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
IOD48_RS12390	COG3150	esterase
IOD48_RS12395	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IOD48_RS12400	COG3151	Protein conserved in bacteria
IOD48_RS12405	COG0494	nUDIX hydrolase
IOD48_RS12420	COG0754	glutathionylspermidine amidase activity
IOD48_RS12425	COG3384	dioxygenase
IOD48_RS12440	COG2960	long-chain fatty acid transporting porin activity
IOD48_RS12465	COG3025	triphosphatase activity
IOD48_RS12470	COG4991	sh3 domain protein
IOD48_RS12485	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IOD48_RS12550	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IOD48_RS12555	COG0358	DNA primase activity
IOD48_RS12560	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IOD48_RS12585	COG2197	response regulator
IOD48_RS12590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD48_RS12590	COG0784	Response regulator, receiver
IOD48_RS12590	COG2205	protein histidine kinase activity
IOD48_RS12590	COG2198	Histidine kinase
IOD48_RS12600	COG3247	response to pH
IOD48_RS12670	COG2376	Dihydroxyacetone kinase
IOD48_RS12675	COG1461	Dihydroxyacetone kinase
IOD48_RS12690	COG2375	cellular response to nickel ion
IOD48_RS12695	COG1695	Transcriptional regulator
IOD48_RS12745	COG0446	pyridine nucleotide-disulphide oxidoreductase
IOD48_RS12745	COG1902	pentaerythritol trinitrate reductase activity
IOD48_RS12765	COG1451	nucleotide metabolic process
IOD48_RS12770	COG0673	inositol 2-dehydrogenase activity
IOD48_RS12775	COG0861	Integral membrane protein TerC family
IOD48_RS12790	COG2721	sulfolactate sulfo-lyase activity
IOD48_RS12800	COG2271	Major facilitator Superfamily
IOD48_RS12805	COG2186	Transcriptional regulator
IOD48_RS12810	COG0586	Pfam SNARE associated Golgi protein
IOD48_RS12820	COG1422	Protein of unknown function (DUF1090)
IOD48_RS12825	COG4575	ribosome binding
IOD48_RS12830	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
IOD48_RS12840	COG2259	Doxx family
IOD48_RS12845	COG0435	Glutathione S-transferase
IOD48_RS12850	COG3152	Membrane
IOD48_RS12855	COG0583	DNA-binding transcription factor activity
IOD48_RS12860	COG1741	Belongs to the pirin family
IOD48_RS12885	COG1929	Belongs to the glycerate kinase type-1 family
IOD48_RS12890	COG2084	Dehydrogenase
IOD48_RS12900	COG2271	Major facilitator Superfamily
IOD48_RS12905	COG2721	sulfolactate sulfo-lyase activity
IOD48_RS12910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOD48_RS12915	COG1349	DNA-binding transcription factor activity
IOD48_RS12925	COG1105	Belongs to the carbohydrate kinase PfkB family
IOD48_RS12930	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IOD48_RS12930	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD48_RS12930	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IOD48_RS12935	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD48_RS12935	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD48_RS12945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD48_RS12950	COG3414	Phosphotransferase system galactitol-specific IIB component
IOD48_RS12955	COG3775	system Galactitol-specific IIC component
IOD48_RS12960	COG1063	alcohol dehydrogenase
IOD48_RS12975	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IOD48_RS12995	COG2823	Periplasmic or secreted lipoprotein
IOD48_RS13000	COG0701	Predicted permease
IOD48_RS13005	COG0702	epimerase
IOD48_RS13010	COG0693	protein deglycase activity
IOD48_RS13025	COG3153	acetyltransferase
IOD48_RS13030	COG3154	lipid carrier protein
IOD48_RS13035	COG0826	peptidase U32
IOD48_RS13040	COG0826	peptidase U32
IOD48_RS13045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD48_RS13050	COG0814	amino acid
IOD48_RS13095	COG0195	Participates in both transcription termination and antitermination
IOD48_RS13135	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IOD48_RS13145	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IOD48_RS13150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IOD48_RS13160	COG1534	Rna-binding protein
IOD48_RS13170	COG2027	D-alanyl-D-alanine carboxypeptidase
IOD48_RS13180	COG0697	spore germination
IOD48_RS13195	COG0142	geranyltranstransferase activity
IOD48_RS13200	COG3423	Transcriptional regulator
IOD48_RS13210	COG5007	Belongs to the BolA IbaG family
IOD48_RS13215	COG3113	response to antibiotic
IOD48_RS13220	COG2854	intermembrane phospholipid transfer
IOD48_RS13225	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IOD48_RS13230	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IOD48_RS13235	COG1127	ABC transporter
IOD48_RS13240	COG0530	calcium, potassium:sodium antiporter activity
IOD48_RS13250	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IOD48_RS13255	COG3117	lipopolysaccharide transmembrane transporter activity
IOD48_RS13260	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IOD48_RS13265	COG1137	ATPase activity
IOD48_RS13270	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IOD48_RS13275	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IOD48_RS13280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD48_RS13290	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD48_RS13295	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IOD48_RS13300	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
IOD48_RS13305	COG5002	protein histidine kinase activity
IOD48_RS13305	COG2198	Histidine kinase
IOD48_RS13305	COG0784	Response regulator, receiver
IOD48_RS13310	COG1312	Catalyzes the dehydration of D-mannonate
IOD48_RS13315	COG1063	alcohol dehydrogenase
IOD48_RS13320	COG2271	Major facilitator Superfamily
IOD48_RS13325	COG1242	4 iron, 4 sulfur cluster binding
IOD48_RS13330	COG0069	glutamate synthase activity
IOD48_RS13330	COG0070	glutamate synthase
IOD48_RS13330	COG0067	glutamate synthase
IOD48_RS13335	COG0493	'glutamate synthase
IOD48_RS13345	COG2969	positive regulation of protein catabolic process
IOD48_RS13350	COG0625	glutathione transferase activity
IOD48_RS13370	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IOD48_RS13375	COG3105	Protein conserved in bacteria
IOD48_RS13380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IOD48_RS13385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IOD48_RS13410	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IOD48_RS13415	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IOD48_RS13420	COG0471	metal ion transport
IOD48_RS13430	COG1802	Transcriptional regulator
IOD48_RS13455	COG2732	(Barnase) inhibitor
IOD48_RS13460	COG1289	transmembrane transporter activity
IOD48_RS13475	COG0583	DNA-binding transcription factor activity
IOD48_RS13480	COG0312	modulator of DNA gyrase
IOD48_RS13485	COG3164	Protein of unknown function
IOD48_RS13490	COG1530	ribonuclease E activity
IOD48_RS13500	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IOD48_RS13505	COG1792	Involved in formation and maintenance of cell shape
IOD48_RS13510	COG1077	Cell shape determining protein MreB Mrl
IOD48_RS13515	COG2200	EAL domain
IOD48_RS13515	COG2199	diguanylate cyclase activity
IOD48_RS13540	COG0511	ligase activity, forming carbon-carbon bonds
IOD48_RS13545	COG0439	Biotin carboxylase
IOD48_RS13550	COG3924	membrane
IOD48_RS13555	COG4145	pantothenate transmembrane transporter activity
IOD48_RS13575	COG1309	transcriptional regulator
IOD48_RS13580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOD48_RS13585	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IOD48_RS13620	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IOD48_RS13640	COG0551	DNA topoisomerase type I activity
IOD48_RS13650	COG0758	DNA mediated transformation
IOD48_RS13680	COG3036	rescue of stalled ribosome
IOD48_RS13685	COG0789	Transcriptional regulator
IOD48_RS13700	COG0202	RNA polymerase activity
IOD48_RS13725	COG0201	protein transport
IOD48_RS13790	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IOD48_RS13805	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IOD48_RS13830	COG0051	transcription antitermination factor activity, RNA binding
IOD48_RS13885	COG2964	Protein conserved in bacteria
IOD48_RS13890	COG0545	Peptidyl-prolyl cis-trans isomerase
IOD48_RS13900	COG1047	Peptidyl-prolyl cis-trans
IOD48_RS13905	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
IOD48_RS13920	COG0488	(ABC) transporter
IOD48_RS13925	COG0429	hydrolase of the alpha beta-hydrolase fold
IOD48_RS13935	COG3954	Phosphoribulokinase
IOD48_RS13940	COG1765	OsmC-like protein
IOD48_RS13950	COG1289	transmembrane transporter activity
IOD48_RS13955	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IOD48_RS13980	COG0738	Major facilitator superfamily
IOD48_RS13985	COG0402	S-adenosylhomocysteine deaminase activity
IOD48_RS13990	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IOD48_RS14015	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IOD48_RS14020	COG0338	D12 class N6 adenine-specific DNA methyltransferase
IOD48_RS14025	COG3266	domain, Protein
IOD48_RS14040	COG4796	Type ii and iii secretion system protein
IOD48_RS14065	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IOD48_RS14070	COG0494	nUDIX hydrolase
IOD48_RS14080	COG1011	Hydrolase
IOD48_RS14085	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IOD48_RS14110	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IOD48_RS14115	COG2183	response to ionizing radiation
IOD48_RS14120	COG1918	ferrous iron import across plasma membrane
IOD48_RS14145	COG1040	competence protein
IOD48_RS14155	COG2610	gluconate transmembrane transporter activity
IOD48_RS14160	COG1640	4-alpha-glucanotransferase
IOD48_RS14165	COG0058	SHG alpha-glucan phosphorylase activity
IOD48_RS14175	COG1349	DNA-binding transcription factor activity
IOD48_RS14190	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IOD48_RS14205	COG0058	SHG alpha-glucan phosphorylase activity
IOD48_RS14230	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IOD48_RS14240	COG2610	gluconate transmembrane transporter activity
IOD48_RS14245	COG3265	gluconokinase activity
IOD48_RS14250	COG1609	Transcriptional regulator
IOD48_RS14255	COG1741	Belongs to the pirin family
IOD48_RS14260	COG0673	inositol 2-dehydrogenase activity
IOD48_RS14270	COG1247	-acetyltransferase
IOD48_RS14275	COG0405	Gamma-glutamyltransferase
IOD48_RS14285	COG0584	glycerophosphoryl diester phosphodiesterase
IOD48_RS14335	COG0559	Belongs to the binding-protein-dependent transport system permease family
IOD48_RS14340	COG0683	leucine binding
IOD48_RS14350	COG0683	leucine binding
IOD48_RS14360	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IOD48_RS14375	COG2177	Part of the ABC transporter FtsEX involved in
IOD48_RS14380	COG2884	Cell division ATP-binding protein ftsE
IOD48_RS14385	COG0552	protein localization to endoplasmic reticulum
IOD48_RS14390	COG0742	ribosomal rna small subunit methyltransferase
IOD48_RS14395	COG3776	membrane
IOD48_RS14405	COG3714	YhhN family
IOD48_RS14420	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IOD48_RS14430	COG0477	Major facilitator Superfamily
IOD48_RS14435	COG0628	permease
IOD48_RS14475	COG3479	Phenolic acid decarboxylase
IOD48_RS14485	COG0747	negative chemotaxis
IOD48_RS14490	COG0601	transmembrane transport
IOD48_RS14495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOD48_RS14505	COG1124	(ABC) transporter
IOD48_RS14515	COG2239	Acts as a magnesium transporter
IOD48_RS14520	COG2081	HI0933 family
IOD48_RS14525	COG0306	phosphate transporter
IOD48_RS14535	COG0589	response to stress
IOD48_RS14555	COG0671	phosphoesterase, PA-phosphatase related
IOD48_RS14560	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IOD48_RS14565	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IOD48_RS14575	COG1454	alcohol dehydrogenase
IOD48_RS14585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IOD48_RS14590	COG1028	Short-chain dehydrogenase reductase Sdr
IOD48_RS14595	COG0583	DNA-binding transcription factor activity
IOD48_RS14600	COG1295	ribonuclease BN
IOD48_RS14605	COG0477	Major facilitator Superfamily
IOD48_RS14610	COG2982	Protein involved in outer membrane biogenesis
IOD48_RS14620	COG0612	Peptidase, M16
IOD48_RS14630	COG2200	EAL domain
IOD48_RS14630	COG2199	diguanylate cyclase activity
IOD48_RS14635	COG0457	Tetratricopeptide repeat
IOD48_RS14635	COG3118	belongs to the thioredoxin family
IOD48_RS14640	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
IOD48_RS14645	COG1215	transferase activity, transferring glycosyl groups
IOD48_RS14675	COG2194	sulfuric ester hydrolase activity
IOD48_RS14690	COG0457	Tetratricopeptide repeat
IOD48_RS14695	COG1215	transferase activity, transferring glycosyl groups
IOD48_RS14705	COG2894	cell division
IOD48_RS14720	COG4608	Belongs to the ABC transporter superfamily
IOD48_RS14725	COG0444	Belongs to the ABC transporter superfamily
IOD48_RS14730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOD48_RS14735	COG0601	transmembrane transport
IOD48_RS14740	COG0747	negative chemotaxis
IOD48_RS14765	COG2223	nitrite transmembrane transporter activity
IOD48_RS14770	COG5571	outer membrane autotransporter
IOD48_RS14775	COG2818	Glycosylase
IOD48_RS14780	COG0456	acetyltransferase
IOD48_RS14785	COG0243	molybdopterin cofactor binding
IOD48_RS14790	COG2885	chlorophyll binding
IOD48_RS14795	COG1609	Transcriptional regulator
IOD48_RS14805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOD48_RS14825	COG2814	Major facilitator Superfamily
IOD48_RS14830	COG2944	sequence-specific DNA binding
IOD48_RS14835	COG1278	Cold shock
IOD48_RS14865	COG3274	enterobacterial common antigen metabolic process
IOD48_RS14870	COG4682	membrane
IOD48_RS14875	COG4682	membrane
IOD48_RS14890	COG4213	ABC transporter substrate-binding protein
IOD48_RS14900	COG4214	carbohydrate transport
IOD48_RS14905	COG1609	Transcriptional regulator
IOD48_RS14905	COG2207	Transcriptional regulator
IOD48_RS14910	COG2992	FlgJ-related protein
IOD48_RS14915	COG0366	Alpha amylase catalytic
IOD48_RS14920	COG3977	Valine--pyruvate aminotransferase
IOD48_RS14925	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IOD48_RS14930	COG1414	Transcriptional regulator
IOD48_RS14935	COG3276	selenocysteine insertion sequence binding
IOD48_RS14945	COG0625	glutathione transferase activity
IOD48_RS14950	COG1566	PFAM secretion protein HlyD family protein
IOD48_RS14970	COG3722	fumarate hydratase activity
IOD48_RS14990	COG2186	Transcriptional regulator
IOD48_RS15000	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IOD48_RS15020	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IOD48_RS15025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IOD48_RS15035	COG4942	peptidase
IOD48_RS15040	COG2861	carbohydrate metabolic process
IOD48_RS15045	COG0463	Glycosyl transferase, family 2
IOD48_RS15055	COG0156	8-amino-7-oxononanoate synthase activity
IOD48_RS15070	COG0859	PFAM glycosyl transferase family 9
IOD48_RS15095	COG0859	PFAM glycosyl transferase family 9
IOD48_RS15105	COG0438	transferase activity, transferring glycosyl groups
IOD48_RS15110	COG1216	Glycosyl transferase, family 2
IOD48_RS15115	COG1519	Transferase
IOD48_RS15150	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IOD48_RS15180	COG0842	Transport permease protein
IOD48_RS15185	COG1131	(ABC) transporter
IOD48_RS15205	COG1561	YicC-like family, N-terminal region
IOD48_RS15210	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IOD48_RS15215	COG2169	Transcriptional regulator
IOD48_RS15215	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IOD48_RS15225	COG2860	membrane
IOD48_RS15245	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IOD48_RS15250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IOD48_RS15255	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IOD48_RS15260	COG1494	fructose-1,6-bisphosphatase
IOD48_RS15270	COG3152	Membrane
IOD48_RS15295	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IOD48_RS15315	COG0786	glutamate:sodium symporter activity
IOD48_RS15320	COG2233	PERMEase
IOD48_RS15325	COG2982	Protein involved in outer membrane biogenesis
IOD48_RS15330	COG1263	PTS System
IOD48_RS15330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IOD48_RS15335	COG1486	melibiose metabolic process
IOD48_RS15345	COG1501	Belongs to the glycosyl hydrolase 31 family
IOD48_RS15350	COG2211	Major facilitator Superfamily
IOD48_RS15380	COG1064	alcohol dehydrogenase
IOD48_RS15390	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IOD48_RS15405	COG1464	Belongs to the NlpA lipoprotein family
IOD48_RS15430	COG0583	DNA-binding transcription factor activity
IOD48_RS15465	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IOD48_RS15475	COG2814	Major facilitator Superfamily
IOD48_RS15485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IOD48_RS15485	COG1263	PTS System
IOD48_RS15490	COG0697	spore germination
IOD48_RS15505	COG2828	Protein conserved in bacteria
IOD48_RS15510	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IOD48_RS15515	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IOD48_RS15520	COG0583	DNA-binding transcription factor activity
IOD48_RS15525	COG3384	dioxygenase
IOD48_RS15535	COG1609	Transcriptional regulator
IOD48_RS15545	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IOD48_RS15545	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IOD48_RS15550	COG1447	Phosphotransferase system cellobiose-specific component IIA
IOD48_RS15555	COG4580	involved in the transport of maltose and maltodextrins
IOD48_RS15580	COG2188	Transcriptional regulator
IOD48_RS15620	COG2271	Major facilitator Superfamily
IOD48_RS15630	COG2197	response regulator
IOD48_RS15635	COG0440	acetolactate synthase activity
IOD48_RS15640	COG0028	Belongs to the TPP enzyme family
IOD48_RS15670	COG2814	Major facilitator Superfamily
IOD48_RS15675	COG0583	DNA-binding transcription factor activity
IOD48_RS15705	COG2149	membrane
IOD48_RS15720	COG2188	Transcriptional regulator
IOD48_RS15730	COG3645	SOS response
IOD48_RS15745	COG5645	(Lipo)protein
IOD48_RS15750	COG0823	Involved in the tonB-independent uptake of proteins
IOD48_RS15755	COG2271	Major facilitator Superfamily
IOD48_RS15765	COG0800	Aldolase
IOD48_RS15770	COG3734	2-keto-3-deoxy-galactonokinase
IOD48_RS15775	COG2186	Transcriptional regulator
IOD48_RS15790	COG0561	phosphatase activity
IOD48_RS15795	COG0187	DNA topoisomerase II activity
IOD48_RS15825	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IOD48_RS15855	COG2091	lysine biosynthetic process via aminoadipic acid
IOD48_RS15860	COG0431	NADPH-dependent FMN reductase
IOD48_RS15865	COG2252	PERMEase
IOD48_RS15870	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IOD48_RS15875	COG0363	glucosamine-6-phosphate deaminase activity
IOD48_RS15880	COG2382	esterase
IOD48_RS15890	COG0704	Plays a role in the regulation of phosphate uptake
IOD48_RS15895	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IOD48_RS15900	COG0581	inorganic phosphate transmembrane transporter activity
IOD48_RS15905	COG0573	inorganic phosphate transmembrane transporter activity
IOD48_RS15910	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IOD48_RS15915	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IOD48_RS15965	COG3312	ion transport
IOD48_RS15980	COG0716	FMN binding
IOD48_RS15985	COG1522	sequence-specific DNA binding
IOD48_RS16015	COG1129	ABC transporter
IOD48_RS16020	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD48_RS16030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOD48_RS16035	COG1609	Transcriptional regulator
IOD48_RS16040	COG0477	Major facilitator Superfamily
IOD48_RS16045	COG2186	Transcriptional regulator
IOD48_RS16070	COG1763	Mo-molybdopterin cofactor biosynthetic process
IOD48_RS16080	COG3084	Protein conserved in bacteria
IOD48_RS16085	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IOD48_RS16095	COG0204	Acyl-transferase
IOD48_RS16115	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IOD48_RS16130	COG3852	Histidine kinase
IOD48_RS16145	COG1011	Hydrolase
IOD48_RS16160	COG0456	acetyltransferase
IOD48_RS16170	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IOD48_RS16185	COG2864	formate dehydrogenase
IOD48_RS16190	COG0437	4 iron, 4 sulfur cluster binding
IOD48_RS16210	COG0205	6-phosphofructokinase activity
IOD48_RS16270	COG2211	Major facilitator Superfamily
IOD48_RS16275	COG1609	Transcriptional regulator
IOD48_RS16280	COG2211	Major facilitator Superfamily
IOD48_RS16295	COG1454	alcohol dehydrogenase
IOD48_RS16300	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD48_RS16305	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD48_RS16310	COG1129	ABC transporter
IOD48_RS16350	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IOD48_RS16355	COG2258	MOSC domain
IOD48_RS16360	COG2205	protein histidine kinase activity
IOD48_RS16365	COG0745	RESPONSE REGULATOR receiver
IOD48_RS16370	COG3678	ATP-independent chaperone mediated protein folding
IOD48_RS16390	COG1575	Belongs to the MenA family. Type 1 subfamily
IOD48_RS16405	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IOD48_RS16410	COG1609	Transcriptional regulator
IOD48_RS16415	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IOD48_RS16430	COG0626	cystathionine gamma-synthase activity
IOD48_RS16435	COG0527	aspartate kinase activity
IOD48_RS16435	COG0460	homoserine dehydrogenase
IOD48_RS16445	COG0737	Belongs to the 5'-nucleotidase family
IOD48_RS16455	COG0583	DNA-binding transcription factor activity
IOD48_RS16465	COG0697	spore germination
IOD48_RS16470	COG0371	Dehydrogenase
IOD48_RS16480	COG2207	Transcriptional regulator
IOD48_RS16485	COG3443	Belongs to the bacterial solute-binding protein 9 family
IOD48_RS16500	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IOD48_RS16515	COG0583	DNA-binding transcription factor activity
IOD48_RS16590	COG3085	chromosome segregation
IOD48_RS16610	COG3978	acetolactate synthase activity
IOD48_RS16625	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IOD48_RS16630	COG0583	DNA-binding transcription factor activity
IOD48_RS16640	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IOD48_RS16645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IOD48_RS16655	COG1811	Na channel or pump
IOD48_RS16680	COG3118	belongs to the thioredoxin family
IOD48_RS16685	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IOD48_RS16690	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IOD48_RS16700	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IOD48_RS16705	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IOD48_RS16710	COG1088	dTDP-glucose 4,6-dehydratase activity
IOD48_RS16715	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IOD48_RS16720	COG0456	acetyltransferase
IOD48_RS16725	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IOD48_RS16730	COG2244	polysaccharide biosynthetic process
IOD48_RS16775	COG3071	HemY protein
IOD48_RS16780	COG2959	enzyme of heme biosynthesis
IOD48_RS16795	COG3072	Adenylate cyclase
IOD48_RS16825	COG1011	Hydrolase
IOD48_RS16830	COG0210	DNA helicase
IOD48_RS16860	COG1280	lysine exporter protein (LysE YggA)
IOD48_RS16870	COG1280	lysine exporter protein (LysE YggA)
IOD48_RS16875	COG2267	carboxylic ester hydrolase activity
IOD48_RS16880	COG0561	phosphatase activity
IOD48_RS16885	COG0697	spore germination
IOD48_RS16890	COG0583	DNA-binding transcription factor activity
IOD48_RS16920	COG3165	ubiquinone biosynthetic process from chorismate
IOD48_RS16940	COG0805	protein transport
IOD48_RS16980	COG1739	Uncharacterized protein family UPF0029
IOD48_RS16990	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
IOD48_RS17065	COG0250	Participates in transcription elongation, termination and antitermination
IOD48_RS17100	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IOD48_RS17105	COG1447	Phosphotransferase system cellobiose-specific component IIA
IOD48_RS17115	COG3706	GGDEF domain
IOD48_RS17130	COG2104	thiamine diphosphate biosynthetic process
IOD48_RS17135	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IOD48_RS17150	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
IOD48_RS17185	COG3678	ATP-independent chaperone mediated protein folding
IOD48_RS17190	COG4191	Histidine kinase
IOD48_RS17200	COG0151	Belongs to the GarS family
IOD48_RS17230	COG0456	acetyltransferase
IOD48_RS17240	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IOD48_RS17290	COG0527	aspartate kinase activity
IOD48_RS17300	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IOD48_RS17310	COG0251	oxidation-reduction process
IOD48_RS17380	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IOD48_RS17390	COG0534	Mate efflux family protein
IOD48_RS17400	COG3237	CsbD-like
IOD48_RS17405	COG0735	belongs to the Fur family
IOD48_RS17415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IOD48_RS17430	COG0305	Participates in initiation and elongation during chromosome replication
IOD48_RS17435	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IOD48_RS17450	COG0432	Pfam Uncharacterised protein family UPF0047
IOD48_RS17455	COG2315	Protein conserved in bacteria
IOD48_RS17470	COG0741	lytic transglycosylase activity
IOD48_RS17475	COG4771	TonB-dependent receptor
IOD48_RS17495	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IOD48_RS17505	COG0483	inositol monophosphate 1-phosphatase activity
IOD48_RS17510	COG1609	Transcriptional regulator
IOD48_RS17515	COG1234	tRNA 3'-trailer cleavage
IOD48_RS17545	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IOD48_RS17555	COG0789	Transcriptional regulator
IOD48_RS17560	COG0625	glutathione transferase activity
IOD48_RS17565	COG2252	PERMEase
IOD48_RS17570	COG0025	NhaP-type Na H and K H
IOD48_RS17575	COG0583	DNA-binding transcription factor activity
IOD48_RS17580	COG1380	Effector of murein hydrolase LrgA
IOD48_RS17585	COG1346	cytolysis
IOD48_RS17590	COG3539	Fimbrial protein
IOD48_RS17620	COG3162	membrane
IOD48_RS17625	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IOD48_RS17635	COG1301	dicarboxylic acid transport
IOD48_RS17640	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
IOD48_RS17675	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD48_RS17680	COG1129	ABC transporter
IOD48_RS17685	COG4191	Histidine kinase
IOD48_RS17685	COG0784	Response regulator, receiver
IOD48_RS17695	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IOD48_RS17705	COG3454	Phosphonate metabolism
IOD48_RS17710	COG4778	phosphonate C-P lyase system protein PhnL
IOD48_RS17715	COG4107	phosphonate C-P lyase system protein PhnK
IOD48_RS17720	COG3627	carbon phosphorus lyase activity
IOD48_RS17725	COG3626	phosphonate metabolism
IOD48_RS17730	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
IOD48_RS17735	COG3624	Phosphonate C-P lyase system protein PhnG
IOD48_RS17740	COG2188	Transcriptional regulator
IOD48_RS17745	COG2764	glyoxalase bleomycin resistance protein dioxygenase
IOD48_RS17750	COG2824	Alkylphosphonate utilization operon protein PhnA
IOD48_RS17760	COG2169	Transcriptional regulator
IOD48_RS17765	COG1486	melibiose metabolic process
IOD48_RS17805	COG0861	Integral membrane protein TerC family
IOD48_RS17820	COG1215	transferase activity, transferring glycosyl groups
IOD48_RS17825	COG1649	PFAM Uncharacterised BCR, COG1649
IOD48_RS17825	COG0726	polysaccharide deacetylase
IOD48_RS17830	COG0457	Tetratricopeptide repeat
IOD48_RS17875	COG1309	transcriptional regulator
IOD48_RS17890	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IOD48_RS17895	COG1027	Aspartate ammonia-lyase
IOD48_RS17900	COG3030	protein affecting phage T7 exclusion by the F plasmid
IOD48_RS17905	COG0531	amino acid
IOD48_RS17970	COG1509	lysine 2,3-aminomutase activity
IOD48_RS17985	COG5510	response to toxic substance
IOD48_RS17990	COG2076	Multidrug Resistance protein
IOD48_RS18010	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IOD48_RS18015	COG1053	succinate dehydrogenase
IOD48_RS18030	COG3264	Mechanosensitive ion channel
IOD48_RS18030	COG1511	domain protein
IOD48_RS18050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD48_RS18070	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IOD48_RS18075	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IOD48_RS18075	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IOD48_RS18080	COG0802	atpase or kinase
IOD48_RS18085	COG0860	N-Acetylmuramoyl-L-alanine amidase
IOD48_RS18105	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IOD48_RS18110	COG0330	HflC and HflK could
IOD48_RS18115	COG0330	HflC and HflK could
IOD48_RS18125	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
IOD48_RS18140	COG0557	exoribonuclease II activity
IOD48_RS18145	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IOD48_RS18150	COG1960	acyl-CoA dehydrogenase activity
IOD48_RS18160	COG3650	response to hydrogen peroxide
IOD48_RS18165	COG1073	alpha beta
IOD48_RS18225	COG2965	DNA replication, synthesis of RNA primer
IOD48_RS18230	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IOD48_RS18240	COG3061	Opacity-associated protein A
IOD48_RS18245	COG0545	Peptidyl-prolyl cis-trans isomerase
IOD48_RS18250	COG1113	amino acid transport
IOD48_RS18260	COG0697	spore germination
IOD48_RS18270	COG0702	epimerase
IOD48_RS18275	COG1733	regulation of RNA biosynthetic process
IOD48_RS18290	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
IOD48_RS18315	COG1253	flavin adenine dinucleotide binding
IOD48_RS18325	COG0729	surface antigen
IOD48_RS18330	COG2911	Protein conserved in bacteria
IOD48_RS18335	COG2105	PFAM AIG2 family protein
IOD48_RS18355	COG1879	ABC-type sugar transport system periplasmic component
IOD48_RS18360	COG1129	ABC transporter
IOD48_RS18365	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD48_RS18370	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD48_RS18380	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IOD48_RS18405	COG0312	modulator of DNA gyrase
IOD48_RS18445	COG3964	amidohydrolase
IOD48_RS18460	COG2706	6-phosphogluconolactonase activity
IOD48_RS18465	COG3711	transcriptional antiterminator
IOD48_RS18465	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD48_RS18470	COG3077	Addiction module antitoxin, RelB DinJ family
IOD48_RS18475	COG2026	Addiction module toxin, RelE StbE family
IOD48_RS18480	COG0602	queuosine metabolic process
IOD48_RS18505	COG1486	melibiose metabolic process
IOD48_RS18510	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IOD48_RS18515	COG0366	Alpha amylase catalytic
IOD48_RS18520	COG1263	PTS System
IOD48_RS18520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IOD48_RS18555	COG2731	YhcH YjgK YiaL family protein
IOD48_RS18560	COG2222	sugar isomerase
IOD48_RS18565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOD48_RS18570	COG1228	amidohydrolase
IOD48_RS18575	COG1288	antiporter activity
IOD48_RS18580	COG2188	Transcriptional regulator
IOD48_RS18605	COG0525	valine-tRNA ligase activity
IOD48_RS18610	COG2927	DNA polymerase III (CHI subunit)
IOD48_RS18620	COG0795	lipopolysaccharide-transporting ATPase activity
IOD48_RS18625	COG0795	lipopolysaccharide-transporting ATPase activity
IOD48_RS18630	COG0433	COG0433 Predicted ATPase
IOD48_RS18645	COG3718	enzyme involved in inositol metabolism
IOD48_RS18650	COG0837	glucose binding
IOD48_RS18650	COG1737	Transcriptional regulator
IOD48_RS18655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOD48_RS18660	COG3962	Belongs to the TPP enzyme family
IOD48_RS18670	COG1082	Xylose isomerase domain protein TIM barrel
IOD48_RS18685	COG3842	ATPase activity
IOD48_RS18690	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IOD48_RS18695	COG0395	ABC-type sugar transport system, permease component
IOD48_RS18700	COG1175	transmembrane transport
IOD48_RS18705	COG1064	alcohol dehydrogenase
IOD48_RS18710	COG0659	secondary active sulfate transmembrane transporter activity
IOD48_RS18715	COG0288	reversible hydration of carbon dioxide
IOD48_RS18725	COG0582	viral genome integration into host DNA
IOD48_RS18740	COG2856	Zn peptidase
IOD48_RS18780	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IOD48_RS18810	COG3596	GTP binding
IOD48_RS18820	COG2378	regulation of single-species biofilm formation
IOD48_RS18850	COG2003	Belongs to the UPF0758 family
IOD48_RS18970	COG3507	Belongs to the glycosyl hydrolase 43 family
IOD48_RS18975	COG2211	Major facilitator Superfamily
IOD48_RS18980	COG2115	Belongs to the xylose isomerase family
IOD48_RS18985	COG4580	involved in the transport of maltose and maltodextrins
IOD48_RS18990	COG3272	Protein of unknown function (DUF1722)
IOD48_RS19010	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IOD48_RS19025	COG0300	oxidoreductase activity
IOD48_RS19030	COG3631	Ketosteroid isomerase-related protein
IOD48_RS19035	COG0789	Transcriptional regulator
IOD48_RS19040	COG3040	lipid binding
IOD48_RS19050	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IOD48_RS19055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOD48_RS19060	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOD48_RS19065	COG1538	Outer membrane efflux protein
IOD48_RS19070	COG0745	RESPONSE REGULATOR receiver
IOD48_RS19075	COG5002	protein histidine kinase activity
IOD48_RS19090	COG2850	peptidyl-arginine hydroxylation
IOD48_RS19120	COG0842	Transport permease protein
IOD48_RS19125	COG0842	Transport permease protein
IOD48_RS19125	COG1129	ABC transporter
IOD48_RS19130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOD48_RS19140	COG1879	ABC-type sugar transport system periplasmic component
IOD48_RS19145	COG1129	ABC transporter
IOD48_RS19150	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD48_RS19160	COG2249	NAD(P)H dehydrogenase (quinone) activity
IOD48_RS19165	COG0583	DNA-binding transcription factor activity
IOD48_RS19175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOD48_RS19180	COG5457	Domain of unknown function (DUF1127)
IOD48_RS19190	COG1566	PFAM secretion protein HlyD family protein
IOD48_RS19205	COG1924	4 iron, 4 sulfur cluster binding
IOD48_RS19210	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
IOD48_RS19225	COG2733	membrane
IOD48_RS19235	COG1917	Cupin 2, conserved barrel domain protein
IOD48_RS19235	COG2207	Transcriptional regulator
IOD48_RS19240	COG5464	transposase or invertase
IOD48_RS19245	COG1012	belongs to the aldehyde dehydrogenase family
IOD48_RS19255	COG0523	cobalamin synthesis protein
IOD48_RS19260	COG2879	small protein
IOD48_RS19265	COG1966	Carbon starvation protein
IOD48_RS19280	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IOD48_RS19285	COG2368	4-hydroxyphenylacetate
IOD48_RS19305	COG3971	2-oxopent-4-enoate hydratase activity
IOD48_RS19315	COG3384	dioxygenase
IOD48_RS19320	COG1012	belongs to the aldehyde dehydrogenase family
IOD48_RS19330	COG0179	Fumarylacetoacetate (FAA) hydrolase
IOD48_RS19340	COG1846	Transcriptional regulator
IOD48_RS19365	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IOD48_RS19375	COG4145	pantothenate transmembrane transporter activity
IOD48_RS19380	COG3734	2-keto-3-deoxy-galactonokinase
IOD48_RS19385	COG0800	Aldolase
IOD48_RS19390	COG1737	Transcriptional regulator
IOD48_RS19400	COG0456	acetyltransferase
IOD48_RS19400	COG1214	PFAM Peptidase M22, glycoprotease
IOD48_RS19405	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IOD48_RS19405	COG3933	PFAM sigma-54 factor interaction domain-containing protein
IOD48_RS19420	COG3715	PTS system
IOD48_RS19425	COG3716	PTS system mannose fructose sorbose family IID component
IOD48_RS19430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IOD48_RS19440	COG5464	transposase or invertase
IOD48_RS19455	COG1484	DNA-dependent DNA replication
IOD48_RS19470	COG2966	Psort location CytoplasmicMembrane, score
IOD48_RS19485	COG2197	response regulator
IOD48_RS19490	COG2197	response regulator
IOD48_RS19500	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IOD48_RS19500	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IOD48_RS19505	COG4114	ferric iron reductase
IOD48_RS19510	COG3706	GGDEF domain
IOD48_RS19545	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
IOD48_RS19550	COG0456	acetyltransferase
IOD48_RS19555	COG1011	Hydrolase
IOD48_RS19565	COG2823	Periplasmic or secreted lipoprotein
IOD48_RS19575	COG4667	esterase of the alpha-beta hydrolase superfamily
IOD48_RS19580	COG0084	hydrolase, TatD family'
IOD48_RS19585	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IOD48_RS19615	COG3726	membrane protein affecting hemolysin expression
IOD48_RS19620	COG0560	Phosphoserine phosphatase
IOD48_RS19625	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IOD48_RS19635	COG0488	(ABC) transporter
IOD48_RS19640	COG0741	lytic transglycosylase activity
IOD48_RS19660	COG2207	Transcriptional regulator
IOD48_RS19660	COG3708	Transcriptional regulator
IOD48_RS19665	COG3045	CreA protein
IOD48_RS19670	COG0745	RESPONSE REGULATOR receiver
IOD48_RS19675	COG2205	protein histidine kinase activity
IOD48_RS19680	COG4452	Inner membrane protein CreD
IOD48_RS19685	COG0745	RESPONSE REGULATOR receiver
IOD48_RS19695	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
IOD48_RS19705	COG0460	homoserine dehydrogenase
IOD48_RS19705	COG0527	aspartate kinase activity
IOD48_RS19715	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IOD48_RS19730	COG1115	amino acid carrier protein
IOD48_RS19735	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IOD48_RS19740	COG0521	Mo-molybdopterin cofactor biosynthetic process
IOD48_RS19745	COG0477	Major facilitator Superfamily
IOD48_RS19750	COG1584	GPR1 FUN34 yaaH family protein
IOD48_RS19755	COG4735	regulation of single-species biofilm formation
IOD48_RS19780	COG0583	DNA-binding transcription factor activity
IOD48_RS19790	COG0196	riboflavin kinase activity
IOD48_RS19805	COG1047	Peptidyl-prolyl cis-trans
IOD48_RS19830	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IOD48_RS19840	COG0505	Belongs to the CarA family
IOD48_RS19890	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IOD48_RS19900	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IOD48_RS19905	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IOD48_RS19920	COG3493	citrate carrier protein
IOD48_RS19930	COG0564	pseudouridine synthase activity
IOD48_RS19940	COG0417	DNA replication proofreading
IOD48_RS19945	COG0235	Class ii aldolase
IOD48_RS19965	COG0586	Pfam SNARE associated Golgi protein
IOD48_RS19975	COG1178	ABC-type Fe3 transport system permease component
IOD48_RS19995	COG2814	Major facilitator Superfamily
IOD48_RS20000	COG2271	Major facilitator Superfamily
IOD48_RS20005	COG0583	DNA-binding transcription factor activity
IOD48_RS20015	COG0738	Major facilitator superfamily
IOD48_RS20060	COG0028	Belongs to the TPP enzyme family
IOD48_RS20070	COG1609	Transcriptional regulator
IOD48_RS20090	COG0768	penicillin binding
IOD48_RS20095	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IOD48_RS20100	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IOD48_RS20115	COG0772	Belongs to the SEDS family
IOD48_RS20140	COG0849	cell division
IOD48_RS20145	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IOD48_RS20165	COG0494	nUDIX hydrolase
IOD48_RS20190	COG1459	type II secretion system
IOD48_RS20195	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IOD48_RS20200	COG4969	Belongs to the N-Me-Phe pilin family
IOD48_RS20210	COG3023	N-Acetylmuramoyl-L-alanine amidase
IOD48_RS20215	COG3725	Membrane protein required for beta-lactamase induction
IOD48_RS20220	COG3940	Belongs to the glycosyl hydrolase 43 family
IOD48_RS20225	COG2211	Major facilitator Superfamily
IOD48_RS20230	COG1113	amino acid transport
IOD48_RS20235	COG2186	Transcriptional regulator
IOD48_RS20240	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IOD48_RS20245	COG0508	dehydrogenase complex catalyzes the overall conversion of
IOD48_RS20250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IOD48_RS20265	COG3064	Membrane
IOD48_RS20310	COG2132	Multicopper oxidase
IOD48_RS20315	COG4993	Dehydrogenase
IOD48_RS20330	COG0288	reversible hydration of carbon dioxide
IOD48_RS20335	COG1131	(ABC) transporter
IOD48_RS20340	COG0842	Transport permease protein
IOD48_RS20345	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD48_RS20350	COG0726	polysaccharide deacetylase
IOD48_RS20370	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IOD48_RS20375	COG0617	tRNA 3'-terminal CCA addition
IOD48_RS20395	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
IOD48_RS20400	COG1643	Atp-dependent helicase
IOD48_RS20495	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IOD48_RS20500	COG4774	siderophore transport
IOD48_RS20505	COG1120	ATPase activity
IOD48_RS20510	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IOD48_RS20515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOD48_RS20535	COG2860	membrane
IOD48_RS20555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IOD48_RS20560	COG3835	regulator
IOD48_RS20575	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IOD48_RS20580	COG0024	Methionine aminopeptidase
IOD48_RS20605	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IOD48_RS20615	COG0575	Belongs to the CDS family
IOD48_RS20620	COG0750	zinc metalloprotease
IOD48_RS20630	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
IOD48_RS20660	COG0587	DNA-directed DNA polymerase activity
IOD48_RS20670	COG1982	Orn Lys Arg decarboxylase major
IOD48_RS20675	COG0346	lactoylglutathione lyase activity
IOD48_RS20685	COG4568	rho-dependent transcription termination
IOD48_RS20700	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IOD48_RS20705	COG3015	lipoprotein NlpE involved in copper resistance
IOD48_RS20710	COG0791	NLP P60 protein
IOD48_RS20720	COG1720	tRNA m6t6A37 methyltransferase activity
IOD48_RS20730	COG1464	Belongs to the NlpA lipoprotein family
IOD48_RS20735	COG2011	ABC-type metal ion transport system permease component
IOD48_RS20745	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IOD48_RS20780	COG0656	L-ascorbic acid biosynthetic process
IOD48_RS20785	COG0583	DNA-binding transcription factor activity
IOD48_RS20790	COG2814	Major facilitator Superfamily
IOD48_RS20800	COG2226	methyltransferase
IOD48_RS20805	COG0741	lytic transglycosylase activity
IOD48_RS20805	COG1388	LysM domain
IOD48_RS20815	COG2226	methyltransferase
IOD48_RS20825	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IOD48_RS20835	COG0583	DNA-binding transcription factor activity
IOD48_RS20845	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IOD48_RS20850	COG1960	acyl-CoA dehydrogenase activity
IOD48_RS20860	COG0121	glutamine amidotransferase
IOD48_RS20865	COG3034	peptidoglycan biosynthetic process
IOD48_RS20880	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IOD48_RS20885	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IOD48_RS20900	COG2991	Protein conserved in bacteria
IOD48_RS20915	COG0454	-acetyltransferase
IOD48_RS20920	COG2195	Cleaves the N-terminal amino acid of tripeptides
IOD48_RS20940	COG1802	Transcriptional regulator
IOD48_RS20945	COG1113	amino acid transport
IOD48_RS20950	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IOD48_RS20955	COG1012	belongs to the aldehyde dehydrogenase family
IOD48_RS20960	COG0579	oxidoreductase
IOD48_RS20975	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
IOD48_RS20980	COG0625	glutathione transferase activity
IOD48_RS20990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IOD48_RS20995	COG0508	dehydrogenase complex catalyzes the overall conversion of
IOD48_RS21000	COG0022	dehydrogenase e1 component
IOD48_RS21005	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IOD48_RS21030	COG0745	RESPONSE REGULATOR receiver
IOD48_RS21045	COG3188	usher protein
IOD48_RS21050	COG3121	Chaperone
IOD48_RS21085	COG0582	viral genome integration into host DNA
IOD48_RS21110	COG0791	NLP P60 protein
IOD48_RS21130	COG3639	organic phosphonate transmembrane transporter activity
IOD48_RS21140	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
IOD48_RS21165	COG3188	usher protein
IOD48_RS21180	COG0765	amino acid transport
IOD48_RS21185	COG4597	amino acid ABC transporter
IOD48_RS21190	COG1126	abc transporter atp-binding protein
IOD48_RS21195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD48_RS21235	COG4302	ethanolamine ammonia-lyase activity
IOD48_RS21240	COG4303	Ethanolamine ammonia lyase large subunit
IOD48_RS21255	COG0833	amino acid
IOD48_RS21260	COG2040	homocysteine
IOD48_RS21265	COG4521	taurine ABC transporter
IOD48_RS21270	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IOD48_RS21275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IOD48_RS21280	COG2175	clavaminate synthase activity
IOD48_RS21290	COG0113	porphobilinogen synthase activity
IOD48_RS21295	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IOD48_RS21300	COG1335	isochorismatase
IOD48_RS21305	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
IOD48_RS21345	COG1785	Belongs to the alkaline phosphatase family
IOD48_RS21355	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IOD48_RS21365	COG3416	Protein conserved in bacteria
IOD48_RS21370	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IOD48_RS21380	COG4126	flavin adenine dinucleotide binding
IOD48_RS21395	COG1940	carbohydrate kinase activity
IOD48_RS21400	COG0419	ATPase involved in DNA repair
IOD48_RS21405	COG0420	3'-5' exonuclease activity
IOD48_RS21430	COG0366	Alpha amylase catalytic
IOD48_RS21435	COG0583	DNA-binding transcription factor activity
IOD48_RS21440	COG1335	isochorismatase
IOD48_RS21450	COG1228	amidohydrolase
IOD48_RS21460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOD48_RS21475	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD48_RS21480	COG0450	alkyl hydroperoxide reductase
IOD48_RS21505	COG1862	Preprotein translocase
IOD48_RS21510	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IOD48_RS21515	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IOD48_RS21535	COG4238	major outer membrane lipoprotein
IOD48_RS21545	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IOD48_RS21545	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IOD48_RS21565	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IOD48_RS21570	COG0667	Aldo Keto reductase
IOD48_RS21580	COG0142	geranyltranstransferase activity
IOD48_RS21600	COG0693	protein deglycase activity
IOD48_RS21605	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IOD48_RS21615	COG2814	Major facilitator Superfamily
IOD48_RS21620	COG0673	inositol 2-dehydrogenase activity
IOD48_RS21635	COG1053	succinate dehydrogenase
IOD48_RS21645	COG1053	succinate dehydrogenase
IOD48_RS21650	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IOD48_RS21655	COG1414	Transcriptional regulator
IOD48_RS21670	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IOD48_RS21675	COG1845	cytochrome c oxidase, subunit III
IOD48_RS21680	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IOD48_RS21685	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IOD48_RS21690	COG2223	nitrite transmembrane transporter activity
IOD48_RS21695	COG3056	Lipoprotein
IOD48_RS21700	COG0271	Belongs to the BolA IbaG family
IOD48_RS21720	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IOD48_RS21725	COG0776	regulation of translation
IOD48_RS21730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IOD48_RS21735	COG1555	photosystem II stabilization
IOD48_RS21740	COG0824	Thioesterase
IOD48_RS21750	COG4533	DNA binding
IOD48_RS21765	COG1522	sequence-specific DNA binding
IOD48_RS21770	COG1132	(ABC) transporter
IOD48_RS21775	COG1132	(ABC) transporter
IOD48_RS21780	COG0347	Belongs to the P(II) protein family
IOD48_RS21785	COG0004	ammonium transporteR
IOD48_RS21790	COG1946	Acyl-CoA thioesterase
IOD48_RS21795	COG3126	Type III secretion system lipoprotein chaperone (YscW)
IOD48_RS21800	COG3695	enzyme binding
IOD48_RS21860	COG2364	Membrane
IOD48_RS21875	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IOD48_RS21885	COG2182	Extracellular solute-binding protein
IOD48_RS21890	COG1175	transmembrane transport
IOD48_RS21895	COG3833	ABC-type maltose transport systems, permease component
IOD48_RS21900	COG3867	Arabinogalactan endo-beta-1,4-galactanase
IOD48_RS21905	COG1874	Beta-galactosidase
IOD48_RS21955	COG0110	maltose O-acetyltransferase activity
IOD48_RS21970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IOD48_RS21975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOD48_RS21980	COG1309	transcriptional regulator
IOD48_RS21985	COG1196	nuclear chromosome segregation
IOD48_RS21985	COG3264	Mechanosensitive ion channel
IOD48_RS21990	COG5464	transposase or invertase
IOD48_RS22000	COG3923	Primosomal replication protein n
IOD48_RS22005	COG2832	Protein of unknown function (DUF454)
IOD48_RS22045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOD48_RS22050	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IOD48_RS22050	COG4651	solute:proton antiporter activity
IOD48_RS22055	COG2223	nitrite transmembrane transporter activity
IOD48_RS22065	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IOD48_RS22070	COG3735	TraB family
IOD48_RS22085	COG1585	Membrane protein implicated in regulation of membrane protease activity
IOD48_RS22090	COG0330	HflC and HflK could
IOD48_RS22095	COG4619	ABC transporter
IOD48_RS22100	COG0390	transport system, permease component
IOD48_RS22105	COG3118	belongs to the thioredoxin family
IOD48_RS22110	COG0300	oxidoreductase activity
IOD48_RS22115	COG2755	lipolytic protein G-D-S-L family
IOD48_RS22120	COG4181	ATPase activity
IOD48_RS22125	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IOD48_RS22145	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IOD48_RS22150	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IOD48_RS22165	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IOD48_RS22175	COG2501	S4 domain
IOD48_RS22225	COG3539	Fimbrial protein
IOD48_RS22230	COG3121	Chaperone
IOD48_RS22235	COG3188	usher protein
IOD48_RS22250	COG1560	Kdo2-lipid A biosynthetic process
IOD48_RS22260	COG3710	Transcriptional regulator
IOD48_RS22265	COG0531	amino acid
IOD48_RS22270	COG1982	Orn Lys Arg decarboxylase major
IOD48_RS22275	COG3104	oligopeptide transport
IOD48_RS22305	COG0673	inositol 2-dehydrogenase activity
IOD48_RS22320	COG1129	ABC transporter
IOD48_RS22325	COG4211	Belongs to the binding-protein-dependent transport system permease family
IOD48_RS22370	COG1566	PFAM secretion protein HlyD family protein
IOD48_RS22375	COG1120	ATPase activity
IOD48_RS22380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOD48_RS22410	COG1473	amidohydrolase
IOD48_RS22415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD48_RS22420	COG0667	Aldo Keto reductase
IOD48_RS22475	COG3775	system Galactitol-specific IIC component
IOD48_RS22480	COG1070	Carbohydrate kinase
IOD48_RS22485	COG1063	alcohol dehydrogenase
IOD48_RS22490	COG2188	Transcriptional regulator
IOD48_RS22505	COG1063	alcohol dehydrogenase
IOD48_RS22525	COG0531	amino acid
IOD48_RS22535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IOD48_RS22540	COG1012	belongs to the aldehyde dehydrogenase family
IOD48_RS22555	COG1113	amino acid transport
IOD48_RS22560	COG2211	Major facilitator Superfamily
IOD48_RS22570	COG0673	inositol 2-dehydrogenase activity
IOD48_RS22580	COG2771	luxR family
IOD48_RS22595	COG3188	usher protein
IOD48_RS22620	COG1609	Transcriptional regulator
IOD48_RS22625	COG0668	transmembrane transport
IOD48_RS22655	COG0778	Nitroreductase
IOD48_RS22660	COG2315	Protein conserved in bacteria
IOD48_RS22700	COG3698	Phosphodiester glycosidase
IOD48_RS22710	COG0697	spore germination
IOD48_RS22725	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IOD48_RS22730	COG0765	amino acid transport
IOD48_RS22735	COG4215	(ABC) transporter
IOD48_RS22745	COG4221	oxidoreductase activity
IOD48_RS22750	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IOD48_RS22755	COG4608	Belongs to the ABC transporter superfamily
IOD48_RS22760	COG0444	Belongs to the ABC transporter superfamily
IOD48_RS22765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOD48_RS22770	COG0601	transmembrane transport
IOD48_RS22775	COG0747	negative chemotaxis
IOD48_RS22800	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IOD48_RS22810	COG0668	transmembrane transport
IOD48_RS22815	COG0583	DNA-binding transcription factor activity
IOD48_RS22825	COG1028	Short-chain dehydrogenase reductase Sdr
IOD48_RS22835	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD48_RS22840	COG1129	ABC transporter
IOD48_RS22850	COG1879	ABC-type sugar transport system periplasmic component
IOD48_RS22855	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IOD48_RS22860	COG2390	Transcriptional regulator
IOD48_RS22865	COG3959	Transketolase, thiamine diphosphate binding domain
IOD48_RS22870	COG3958	Transketolase
IOD48_RS22875	COG2977	Belongs to the P-Pant transferase superfamily
IOD48_RS22880	COG4771	TonB-dependent receptor
IOD48_RS22885	COG2382	esterase
IOD48_RS22890	COG3251	PFAM MbtH domain protein
IOD48_RS22895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IOD48_RS22895	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
IOD48_RS22900	COG1120	ATPase activity
IOD48_RS22905	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOD48_RS22910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOD48_RS22920	COG4592	Periplasmic binding protein
IOD48_RS22925	COG1169	isochorismate synthase
IOD48_RS22930	COG1021	2,3-dihydroxybenzoate-AMP ligase
IOD48_RS22935	COG1535	isochorismatase
IOD48_RS22935	COG3433	isochorismatase activity
IOD48_RS22940	COG1028	Short-chain dehydrogenase reductase Sdr
IOD48_RS22950	COG1966	Carbon starvation protein
IOD48_RS22955	COG2879	small protein
IOD48_RS22960	COG2211	Major facilitator Superfamily
IOD48_RS22975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOD48_RS22985	COG2188	Transcriptional regulator
IOD48_RS22995	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IOD48_RS23020	COG1028	Short-chain dehydrogenase reductase Sdr
IOD48_RS23025	COG0371	Dehydrogenase
IOD48_RS23030	COG1129	ABC transporter
IOD48_RS23035	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD48_RS23065	COG2271	Major facilitator Superfamily
IOD48_RS23070	COG0483	inositol monophosphate 1-phosphatase activity
IOD48_RS23080	COG0402	S-adenosylhomocysteine deaminase activity
IOD48_RS23090	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IOD48_RS23105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IOD48_RS23115	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD48_RS23120	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD48_RS23125	COG1129	ABC transporter
IOD48_RS23150	COG0436	Aminotransferase
IOD48_RS23155	COG1475	DNA binding
IOD48_RS23160	COG3969	phosphoadenosine phosphosulfate
IOD48_RS23165	COG0583	DNA-binding transcription factor activity
IOD48_RS23170	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IOD48_RS23190	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IOD48_RS23195	COG3719	Belongs to the RNase T2 family
IOD48_RS23200	COG3069	C4-dicarboxylate transmembrane transporter activity
IOD48_RS23220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IOD48_RS23235	COG0583	DNA-binding transcription factor activity
IOD48_RS23250	COG1686	Belongs to the peptidase S11 family
IOD48_RS23255	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IOD48_RS23260	COG0772	Belongs to the SEDS family
IOD48_RS23265	COG0768	penicillin binding
IOD48_RS23275	COG0799	negative regulation of ribosome biogenesis
IOD48_RS23290	COG1466	dna polymerase III delta subunit
IOD48_RS23305	COG2888	peptidyl-tyrosine sulfation
IOD48_RS23320	COG1126	abc transporter atp-binding protein
IOD48_RS23325	COG0765	amino acid transport
IOD48_RS23330	COG0765	amino acid transport
IOD48_RS23355	COG1702	phosphate starvation-inducible protein PhoH
IOD48_RS23365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOD48_RS23405	COG0367	asparagine synthase
IOD48_RS23410	COG0647	UMP catabolic process
IOD48_RS23415	COG1940	carbohydrate kinase activity
IOD48_RS23415	COG1846	Transcriptional regulator
IOD48_RS23420	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IOD48_RS23460	COG0735	belongs to the Fur family
IOD48_RS23475	COG0596	Alpha beta hydrolase
IOD48_RS23485	COG0033	Phosphoglucomutase
IOD48_RS23495	COG0745	RESPONSE REGULATOR receiver
IOD48_RS23500	COG2205	protein histidine kinase activity
IOD48_RS23530	COG0415	Belongs to the DNA photolyase family
IOD48_RS23545	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IOD48_RS23550	COG1984	allophanate hydrolase subunit 2
IOD48_RS23585	COG2009	succinate dehydrogenase
IOD48_RS23590	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IOD48_RS23595	COG1053	succinate dehydrogenase
IOD48_RS23600	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IOD48_RS23605	COG0567	Dehydrogenase, E1 component
IOD48_RS23610	COG0508	dehydrogenase complex catalyzes the overall conversion of
IOD48_RS23620	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IOD48_RS23625	COG1271	oxidase subunit
IOD48_RS23630	COG1294	oxidase, subunit
IOD48_RS23635	COG4890	Cyd operon protein YbgT
IOD48_RS23640	COG3790	cyd operon protein YbgE
IOD48_RS23645	COG0824	Thioesterase
IOD48_RS23650	COG0811	peptide transport
IOD48_RS23655	COG0848	biopolymer transport protein
IOD48_RS23660	COG3064	Membrane
IOD48_RS23670	COG2885	chlorophyll binding
IOD48_RS23675	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
IOD48_RS23720	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IOD48_RS23725	COG3201	nicotinamide mononucleotide transporter
IOD48_RS23740	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IOD48_RS23750	COG2017	converts alpha-aldose to the beta-anomer
IOD48_RS23760	COG1085	galactose-1-phosphate uridylyltransferase
IOD48_RS23770	COG1119	ATPase activity
IOD48_RS23775	COG2005	Transcriptional regulator
IOD48_RS23775	COG3585	molybdate ion transport
IOD48_RS23785	COG0725	ABC transporter, periplasmic molybdate-binding protein
IOD48_RS23790	COG4149	molybdate abc transporter
IOD48_RS23800	COG0561	phosphatase activity
IOD48_RS23825	COG2200	EAL domain
IOD48_RS23830	COG0789	Transcriptional regulator
IOD48_RS23870	COG4677	pectinesterase activity
IOD48_RS23910	COG1881	PFAM PEBP family protein
IOD48_RS23915	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IOD48_RS23930	COG2226	methyltransferase
IOD48_RS23955	COG0642	Histidine kinase
IOD48_RS23960	COG0745	RESPONSE REGULATOR receiver
IOD48_RS23980	COG0521	Mo-molybdopterin cofactor biosynthetic process
IOD48_RS23990	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IOD48_RS23995	COG0314	molybdopterin synthase activity
IOD48_RS24000	COG0670	Belongs to the BI1 family
IOD48_RS24005	COG0392	lysyltransferase activity
IOD48_RS24010	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IOD48_RS24015	COG3568	Endonuclease Exonuclease Phosphatase
IOD48_RS24025	COG0842	Transport permease protein
IOD48_RS24030	COG0842	Transport permease protein
IOD48_RS24035	COG1131	(ABC) transporter
IOD48_RS24040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOD48_RS24045	COG1309	transcriptional regulator
IOD48_RS24050	COG0583	DNA-binding transcription factor activity
IOD48_RS24060	COG2271	Major facilitator Superfamily
IOD48_RS24065	COG1028	Short-chain dehydrogenase reductase Sdr
IOD48_RS24070	COG3959	Transketolase, thiamine diphosphate binding domain
IOD48_RS24075	COG3958	Transketolase
IOD48_RS24080	COG0513	Belongs to the DEAD box helicase family
IOD48_RS24085	COG1199	ATP-dependent helicase activity
IOD48_RS24090	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IOD48_RS24100	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IOD48_RS24110	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IOD48_RS24120	COG0668	transmembrane transport
IOD48_RS24125	COG1126	abc transporter atp-binding protein
IOD48_RS24130	COG0765	amino acid transport
IOD48_RS24135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD48_RS24150	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IOD48_RS24155	COG2194	sulfuric ester hydrolase activity
IOD48_RS24170	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IOD48_RS24175	COG2723	6-phospho-beta-galactosidase activity
IOD48_RS24180	COG2188	Transcriptional regulator
IOD48_RS24185	COG1376	ErfK ybiS ycfS ynhG family protein
IOD48_RS24190	COG2365	Tyrosine phosphatase family
IOD48_RS24195	COG0488	(ABC) transporter
IOD48_RS24205	COG2271	Major facilitator Superfamily
IOD48_RS24210	COG1609	Transcriptional regulator
IOD48_RS24220	COG0561	phosphatase activity
IOD48_RS24225	COG1882	Formate acetyltransferase
IOD48_RS24230	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IOD48_RS24235	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IOD48_RS24240	COG0303	'Molybdopterin
IOD48_RS24255	COG0747	negative chemotaxis
IOD48_RS24275	COG2223	nitrite transmembrane transporter activity
IOD48_RS24285	COG2133	pyrroloquinoline quinone binding
IOD48_RS24290	COG0625	glutathione transferase activity
IOD48_RS24300	COG1686	Belongs to the peptidase S11 family
IOD48_RS24305	COG1349	DNA-binding transcription factor activity
IOD48_RS24310	COG0671	phosphoesterase, PA-phosphatase related
IOD48_RS24315	COG2814	Major facilitator Superfamily
IOD48_RS24320	COG0561	phosphatase activity
IOD48_RS24325	COG0738	Major facilitator superfamily
IOD48_RS24330	COG3226	Transcriptional regulator
IOD48_RS24355	COG0778	Nitroreductase
IOD48_RS24370	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IOD48_RS24375	COG3842	ATPase activity
IOD48_RS24380	COG1176	ABC-type spermidine putrescine transport system, permease component I
IOD48_RS24385	COG1177	transmembrane transport
IOD48_RS24400	COG0745	RESPONSE REGULATOR receiver
IOD48_RS24405	COG5002	protein histidine kinase activity
IOD48_RS24410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD48_RS24415	COG4160	amino acid transport
IOD48_RS24420	COG4215	(ABC) transporter
IOD48_RS24425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD48_RS24430	COG1126	abc transporter atp-binding protein
IOD48_RS24440	COG5001	Diguanylate cyclase
IOD48_RS24440	COG3706	GGDEF domain
IOD48_RS24440	COG2203	Gaf domain
IOD48_RS24440	COG4251	negative regulation of phosphorylation
IOD48_RS24445	COG3023	N-Acetylmuramoyl-L-alanine amidase
IOD48_RS24450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IOD48_RS24455	COG0702	epimerase
IOD48_RS24460	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
IOD48_RS24465	COG0028	Belongs to the TPP enzyme family
IOD48_RS24475	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IOD48_RS24485	COG2431	L-lysine efflux transmembrane transporter activity
IOD48_RS24495	COG3593	DNA synthesis involved in DNA repair
IOD48_RS24500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOD48_RS24510	COG1278	Cold shock
IOD48_RS24520	COG0542	response to heat
IOD48_RS24535	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IOD48_RS24540	COG4988	ABC transporter
IOD48_RS24545	COG0492	ferredoxin-NADP+ reductase activity
IOD48_RS24555	COG1178	ABC-type Fe3 transport system permease component
IOD48_RS24555	COG1674	ftsk spoiiie
IOD48_RS24565	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IOD48_RS24575	COG0243	molybdopterin cofactor binding
IOD48_RS24580	COG0437	4 iron, 4 sulfur cluster binding
IOD48_RS24585	COG3302	dmso reductase anchor subunit
IOD48_RS24590	COG0477	Major facilitator Superfamily
IOD48_RS24595	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IOD48_RS24600	COG1882	Formate acetyltransferase
IOD48_RS24605	COG2116	formate transmembrane transporter activity
IOD48_RS24610	COG1944	ATP diphosphatase activity
IOD48_RS24615	COG2323	membrane
IOD48_RS24635	COG0539	negative regulation of cytoplasmic translation
IOD48_RS24645	COG0658	competence protein
IOD48_RS24645	COG2333	competence protein COMEC
IOD48_RS24660	COG3214	Protein conserved in bacteria
IOD48_RS24675	COG3173	Aminoglycoside phosphotransferase
IOD48_RS24680	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IOD48_RS24685	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IOD48_RS24695	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
IOD48_RS24705	COG2989	Protein conserved in bacteria
IOD48_RS24710	COG3108	Peptidase M15
IOD48_RS24715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IOD48_RS24720	COG1448	Aminotransferase
IOD48_RS24725	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IOD48_RS24745	COG0814	amino acid
IOD48_RS24755	COG1473	amidohydrolase
IOD48_RS24765	COG0308	aminopeptidase N
IOD48_RS24775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IOD48_RS24780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD48_RS24785	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IOD48_RS24790	COG0431	NADPH-dependent FMN reductase
IOD48_RS24805	COG0633	Ferredoxin
IOD48_RS24805	COG3217	Mosc domain protein beta barrel domain protein
IOD48_RS24815	COG0488	(ABC) transporter
IOD48_RS24820	COG2995	paraquat-inducible protein a
IOD48_RS24825	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IOD48_RS24825	COG3008	intermembrane lipid transfer
IOD48_RS24830	COG3009	Protein conserved in bacteria
IOD48_RS24835	COG3130	regulation of translation
IOD48_RS24845	COG1067	ATP-dependent peptidase activity
IOD48_RS24865	COG3070	regulator of competence-specific genes
IOD48_RS24870	COG1289	transmembrane transporter activity
IOD48_RS24875	COG3304	Inner membrane component domain
IOD48_RS24880	COG0210	DNA helicase
IOD48_RS24890	COG1832	CoA-binding protein
IOD48_RS24905	COG1881	PFAM PEBP family protein
IOD48_RS24910	COG2207	Transcriptional regulator
IOD48_RS24925	COG0670	Belongs to the BI1 family
IOD48_RS24950	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IOD48_RS24955	COG1012	belongs to the aldehyde dehydrogenase family
IOD48_RS24960	COG4638	Rieske (2fe-2S)
IOD48_RS24965	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IOD48_RS24970	COG0473	3-isopropylmalate dehydrogenase activity
IOD48_RS24975	COG0583	DNA-binding transcription factor activity
IOD48_RS24980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IOD48_RS24985	COG1012	belongs to the aldehyde dehydrogenase family
IOD48_RS24990	COG1917	Cupin 2, conserved barrel domain protein
IOD48_RS24990	COG1396	sequence-specific DNA binding
IOD48_RS24995	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IOD48_RS25000	COG0174	glutamine synthetase
IOD48_RS25005	COG0531	amino acid
IOD48_RS25020	COG1028	Short-chain dehydrogenase reductase Sdr
IOD48_RS25050	COG3729	General stress protein
IOD48_RS25060	COG2233	PERMEase
IOD48_RS25095	COG1309	transcriptional regulator
IOD48_RS25110	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IOD48_RS25120	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IOD48_RS25140	COG1702	phosphate starvation-inducible protein PhoH
IOD48_RS25155	COG1335	isochorismatase
IOD48_RS25165	COG0583	DNA-binding transcription factor activity
IOD48_RS25170	COG1309	transcriptional regulator
IOD48_RS25210	COG3381	protein complex oligomerization
IOD48_RS25245	COG5645	(Lipo)protein
IOD48_RS25260	COG1560	Kdo2-lipid A biosynthetic process
IOD48_RS25305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IOD48_RS25325	COG2814	Major facilitator Superfamily
IOD48_RS25330	COG0583	DNA-binding transcription factor activity
IOD48_RS25335	COG1530	ribonuclease E activity
IOD48_RS25355	COG1399	metal-binding, possibly nucleic acid-binding protein
IOD48_RS25375	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IOD48_RS25390	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IOD48_RS25395	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IOD48_RS25400	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IOD48_RS25410	COG0470	DNA polymerase III
IOD48_RS25415	COG0084	hydrolase, TatD family'
IOD48_RS25425	COG0537	adenosine 5'-monophosphoramidase activity
IOD48_RS25430	COG5633	Lipoprotein
IOD48_RS25455	COG1252	NADH dehydrogenase
IOD48_RS25460	COG3134	Outer membrane lipoprotein
IOD48_RS25475	COG1309	transcriptional regulator
IOD48_RS25490	COG1388	LysM domain
IOD48_RS25490	COG1376	ErfK ybiS ycfS ynhG family protein
IOD48_RS25495	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IOD48_RS25505	COG4591	ABC-type transport system involved in lipoprotein release permease component
IOD48_RS25515	COG4591	ABC-type transport system involved in lipoprotein release permease component
IOD48_RS25525	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IOD48_RS25535	COG2390	Transcriptional regulator
IOD48_RS25550	COG3395	kinase activity
IOD48_RS25565	COG0698	ribose 5-phosphate isomerase
IOD48_RS25570	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IOD48_RS25575	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IOD48_RS25580	COG0318	PFAM AMP-dependent synthetase and ligase
IOD48_RS25595	COG1177	transmembrane transport
IOD48_RS25615	COG1943	Transposase
IOD48_RS25620	COG2850	peptidyl-arginine hydroxylation
IOD48_RS25625	COG2205	protein histidine kinase activity
IOD48_RS25645	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IOD48_RS25665	COG1187	pseudouridine synthase activity
IOD48_RS25670	COG3667	copper resistance
IOD48_RS25675	COG2372	response to copper ion
IOD48_RS25680	COG1276	copper resistance
IOD48_RS25685	COG0745	RESPONSE REGULATOR receiver
IOD48_RS25690	COG2205	protein histidine kinase activity
IOD48_RS25705	COG3436	PFAM IS66 Orf2 family protein
IOD48_RS25710	COG4372	Transposase
IOD48_RS25740	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IOD48_RS25765	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IOD48_RS25795	COG2801	Transposase and inactivated derivatives
IOD48_RS25815	COG5001	Diguanylate cyclase
IOD48_RS25835	COG0501	Belongs to the peptidase M48B family
IOD48_RS25850	COG0542	response to heat
IOD48_RS25855	COG0071	Belongs to the small heat shock protein (HSP20) family
IOD48_RS25895	COG2801	Transposase and inactivated derivatives
IOD48_RS25930	COG4770	biotin carboxylase activity
IOD48_RS25935	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IOD48_RS25945	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IOD48_RS25950	COG1914	H( )-stimulated, divalent metal cation uptake system
IOD48_RS25965	COG0840	transmembrane signaling receptor activity
IOD48_RS25995	COG0697	spore germination
IOD48_RS26015	COG4770	biotin carboxylase activity
IOD48_RS26030	COG1126	abc transporter atp-binding protein
IOD48_RS26075	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IOD48_RS26080	COG3118	belongs to the thioredoxin family
IOD48_RS26085	COG1902	pentaerythritol trinitrate reductase activity
IOD48_RS26090	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IOD48_RS26095	COG1028	Short-chain dehydrogenase reductase Sdr
IOD48_RS26100	COG3039	Transposase
IOD48_RS26105	COG1393	Belongs to the ArsC family
IOD48_RS26110	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IOD48_RS26135	COG1609	Transcriptional regulator
IOD48_RS26145	COG1129	ABC transporter
IOD48_RS26150	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD48_RS26300	COG2223	nitrite transmembrane transporter activity
IOD48_RS26310	COG1609	Transcriptional regulator
IOD48_RS26365	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOD48_RS26395	COG0739	heme binding
IOD48_RS26405	COG2132	Multicopper oxidase