locus-tag	class	description
IOD25_RS00010	COG1611	Belongs to the LOG family
IOD25_RS00025	COG3098	single-species biofilm formation
IOD25_RS00030	COG0564	pseudouridine synthase activity
IOD25_RS00035	COG0716	FMN binding
IOD25_RS00040	COG2271	Major facilitator Superfamily
IOD25_RS00045	COG4948	Mandelate Racemase Muconate Lactonizing
IOD25_RS00050	COG4948	Mandelate Racemase Muconate Lactonizing
IOD25_RS00055	COG1929	Belongs to the glycerate kinase type-1 family
IOD25_RS00060	COG3850	Histidine kinase
IOD25_RS00060	COG3437	response regulator, receiver
IOD25_RS00060	COG2205	protein histidine kinase activity
IOD25_RS00060	COG4999	Histidine kinase
IOD25_RS00070	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IOD25_RS00075	COG3956	TIGRFAM MazG family protein
IOD25_RS00095	COG0602	queuosine metabolic process
IOD25_RS00100	COG0720	synthase
IOD25_RS00120	COG2234	aminopeptidase activity
IOD25_RS00180	COG1388	LysM domain
IOD25_RS00180	COG4942	peptidase
IOD25_RS00185	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IOD25_RS00210	COG0163	prenyltransferase activity
IOD25_RS00215	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IOD25_RS00255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOD25_RS00260	COG4558	Periplasmic binding protein
IOD25_RS00265	COG3720	iron ion transport
IOD25_RS00285	COG0679	Auxin Efflux Carrier
IOD25_RS00300	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IOD25_RS00305	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IOD25_RS00310	COG1121	(ABC) transporter
IOD25_RS00320	COG1609	Transcriptional regulator
IOD25_RS00325	COG1940	carbohydrate kinase activity
IOD25_RS00330	COG1447	Phosphotransferase system cellobiose-specific component IIA
IOD25_RS00335	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IOD25_RS00340	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IOD25_RS00345	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IOD25_RS00350	COG4580	involved in the transport of maltose and maltodextrins
IOD25_RS00360	COG2723	6-phospho-beta-galactosidase activity
IOD25_RS00370	COG0309	Hydrogenase expression formation protein (HypE)
IOD25_RS00375	COG0409	Hydrogenase expression formation protein
IOD25_RS00380	COG0298	carbon dioxide binding
IOD25_RS00385	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IOD25_RS00400	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IOD25_RS00405	COG0651	ATP synthesis coupled electron transport
IOD25_RS00410	COG0650	Formate hydrogenlyase subunit 4
IOD25_RS00415	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
IOD25_RS00415	COG3261	NADH dehydrogenase
IOD25_RS00420	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IOD25_RS00425	COG3260	NADH ubiquinone oxidoreductase 20
IOD25_RS00435	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
IOD25_RS00445	COG2723	6-phospho-beta-galactosidase activity
IOD25_RS00450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IOD25_RS00450	COG1263	PTS System
IOD25_RS00455	COG1609	Transcriptional regulator
IOD25_RS00460	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IOD25_RS00465	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
IOD25_RS00470	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
IOD25_RS00495	COG1349	DNA-binding transcription factor activity
IOD25_RS00500	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD25_RS00505	COG1028	Short-chain dehydrogenase reductase Sdr
IOD25_RS00515	COG3732	PTS system glucitol sorbitol-specific
IOD25_RS00520	COG3730	PTS system glucitol sorbitol-specific
IOD25_RS00525	COG2951	lytic endotransglycosylase activity
IOD25_RS00530	COG1121	(ABC) transporter
IOD25_RS00535	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IOD25_RS00540	COG0803	Belongs to the bacterial solute-binding protein 9 family
IOD25_RS00545	COG1546	Belongs to the CinA family
IOD25_RS00565	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IOD25_RS00595	COG2823	Periplasmic or secreted lipoprotein
IOD25_RS00600	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IOD25_RS00605	COG1238	metal cluster binding
IOD25_RS00625	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IOD25_RS00630	COG2814	Major facilitator Superfamily
IOD25_RS00635	COG1566	PFAM secretion protein HlyD family protein
IOD25_RS00640	COG1846	Transcriptional regulator
IOD25_RS00650	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IOD25_RS00660	COG4176	ABC-type proline glycine betaine transport system permease component
IOD25_RS00675	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IOD25_RS00685	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IOD25_RS00690	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IOD25_RS00695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOD25_RS00700	COG4575	ribosome binding
IOD25_RS00715	COG2916	Histone family protein nucleoid-structuring protein H-NS
IOD25_RS00730	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IOD25_RS00735	COG0640	Transcriptional regulator
IOD25_RS00745	COG0583	DNA-binding transcription factor activity
IOD25_RS00750	COG3284	Transcriptional regulator
IOD25_RS00760	COG3539	Fimbrial protein
IOD25_RS00765	COG3121	Chaperone
IOD25_RS00785	COG3188	usher protein
IOD25_RS00795	COG3539	Fimbrial protein
IOD25_RS00800	COG2197	response regulator
IOD25_RS00815	COG1028	Short-chain dehydrogenase reductase Sdr
IOD25_RS00825	COG0235	Class ii aldolase
IOD25_RS00835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD25_RS00870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOD25_RS00875	COG2207	Transcriptional regulator
IOD25_RS00875	COG3708	Transcriptional regulator
IOD25_RS00960	COG0673	inositol 2-dehydrogenase activity
IOD25_RS00965	COG3732	PTS system glucitol sorbitol-specific
IOD25_RS00980	COG3423	Transcriptional regulator
IOD25_RS01000	COG5290	Psort location Cytoplasmic, score
IOD25_RS01010	COG0582	viral genome integration into host DNA
IOD25_RS01025	COG2867	negative regulation of translational initiation
IOD25_RS01040	COG0497	DNA recombination
IOD25_RS01055	COG4536	flavin adenine dinucleotide binding
IOD25_RS01060	COG4137	Cytochrome C assembly protein
IOD25_RS01065	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IOD25_RS01100	COG2885	chlorophyll binding
IOD25_RS01105	COG2199	diguanylate cyclase activity
IOD25_RS01115	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IOD25_RS01120	COG0287	Prephenate dehydrogenase
IOD25_RS01120	COG1605	Chorismate mutase
IOD25_RS01130	COG0077	Prephenate dehydratase
IOD25_RS01130	COG1605	Chorismate mutase
IOD25_RS01140	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IOD25_RS01145	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IOD25_RS01160	COG0542	response to heat
IOD25_RS01185	COG0477	Major facilitator Superfamily
IOD25_RS01190	COG5544	Lipoprotein
IOD25_RS01195	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IOD25_RS01205	COG3148	PFAM DTW domain containing protein
IOD25_RS01210	COG3118	belongs to the thioredoxin family
IOD25_RS01215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IOD25_RS01230	COG0513	Belongs to the DEAD box helicase family
IOD25_RS01240	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IOD25_RS01255	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
IOD25_RS01260	COG3026	antisigma factor binding
IOD25_RS01265	COG3086	response to oxidative stress
IOD25_RS01275	COG0681	Belongs to the peptidase S26 family
IOD25_RS01295	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IOD25_RS01305	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IOD25_RS01310	COG1737	Transcriptional regulator
IOD25_RS01315	COG0560	Phosphoserine phosphatase
IOD25_RS01330	COG0047	phosphoribosylformylglycinamidine synthase activity
IOD25_RS01330	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IOD25_RS01335	COG2205	protein histidine kinase activity
IOD25_RS01340	COG3170	Tfp pilus assembly protein FimV
IOD25_RS01345	COG2204	response regulator
IOD25_RS01350	COG0347	Belongs to the P(II) protein family
IOD25_RS01355	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IOD25_RS01355	COG1017	nitric oxide dioxygenase activity
IOD25_RS01365	COG2259	Doxx family
IOD25_RS01370	COG1940	carbohydrate kinase activity
IOD25_RS01375	COG0457	Tetratricopeptide repeat
IOD25_RS01380	COG0477	Major facilitator Superfamily
IOD25_RS01380	COG2814	Major facilitator Superfamily
IOD25_RS01385	COG2017	converts alpha-aldose to the beta-anomer
IOD25_RS01390	COG2814	Major facilitator Superfamily
IOD25_RS01395	COG3711	transcriptional antiterminator
IOD25_RS01400	COG3683	transport system, periplasmic component
IOD25_RS01405	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
IOD25_RS01435	COG0822	iron-sulfur transferase activity
IOD25_RS01455	COG0633	Ferredoxin
IOD25_RS01460	COG2975	iron-sulfur cluster assembly
IOD25_RS01480	COG2897	thiosulfate sulfurtransferase activity
IOD25_RS01485	COG2373	Large extracellular alpha-helical protein
IOD25_RS01490	COG4953	penicillin-binding protein 1C
IOD25_RS01520	COG2976	Protein conserved in bacteria
IOD25_RS01540	COG1645	bacterial-type flagellum-dependent swarming motility
IOD25_RS01550	COG0517	IMP dehydrogenase activity
IOD25_RS01550	COG0516	GMP reductase activity
IOD25_RS01560	COG3119	arylsulfatase activity
IOD25_RS01565	COG0641	radical SAM
IOD25_RS01585	COG2200	EAL domain
IOD25_RS01600	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IOD25_RS01615	COG2723	6-phospho-beta-galactosidase activity
IOD25_RS01625	COG2233	PERMEase
IOD25_RS01640	COG1393	Belongs to the ArsC family
IOD25_RS01645	COG4783	chaperone-mediated protein folding
IOD25_RS01655	COG0628	permease
IOD25_RS01660	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IOD25_RS01665	COG2716	regulation of RNA biosynthetic process
IOD25_RS01675	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
IOD25_RS01685	COG2321	neutral zinc metallopeptidase
IOD25_RS01690	COG1444	tRNA N-acetyltransferase activity
IOD25_RS01695	COG0400	carboxylic ester hydrolase activity
IOD25_RS01710	COG1393	Belongs to the ArsC family
IOD25_RS01720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IOD25_RS01725	COG0493	'glutamate synthase
IOD25_RS01725	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IOD25_RS01735	COG5342	invasion associated locus B
IOD25_RS01740	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IOD25_RS01745	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IOD25_RS01755	COG4810	utilization protein
IOD25_RS01845	COG0860	N-Acetylmuramoyl-L-alanine amidase
IOD25_RS01865	COG2837	iron assimilation
IOD25_RS01875	COG4150	thiosulfate binding
IOD25_RS01880	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IOD25_RS01885	COG4208	sulfate ABC transporter
IOD25_RS01890	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IOD25_RS01900	COG4319	ketosteroid isomerase
IOD25_RS01935	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IOD25_RS01955	COG3530	Putative quorum-sensing-regulated virulence factor
IOD25_RS01960	COG0385	Bile acid
IOD25_RS01965	COG0583	DNA-binding transcription factor activity
IOD25_RS02005	COG3415	Transposase
IOD25_RS02010	COG3415	Transposase
IOD25_RS02025	COG2199	diguanylate cyclase activity
IOD25_RS02025	COG2200	EAL domain
IOD25_RS02030	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IOD25_RS02045	COG0667	Aldo Keto reductase
IOD25_RS02050	COG3961	Belongs to the TPP enzyme family
IOD25_RS02065	COG3279	Response regulator of the LytR AlgR family
IOD25_RS02070	COG3275	phosphorelay sensor kinase activity
IOD25_RS02085	COG0436	Aminotransferase
IOD25_RS02095	COG2807	transmembrane transport
IOD25_RS02100	COG0590	tRNA wobble adenosine to inosine editing
IOD25_RS02105	COG0583	DNA-binding transcription factor activity
IOD25_RS02140	COG2885	chlorophyll binding
IOD25_RS02180	COG3179	chitinase
IOD25_RS02320	COG2116	formate transmembrane transporter activity
IOD25_RS02325	COG2853	Lipoprotein
IOD25_RS02335	COG3691	Protein conserved in bacteria
IOD25_RS02350	COG2062	phosphohistidine phosphatase, SixA
IOD25_RS02375	COG0730	response to heat
IOD25_RS02380	COG3101	peptidyl-lysine hydroxylation
IOD25_RS02395	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IOD25_RS02415	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IOD25_RS02425	COG0586	Pfam SNARE associated Golgi protein
IOD25_RS02435	COG0285	dihydrofolate synthase activity
IOD25_RS02440	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
IOD25_RS02445	COG1286	toxin biosynthetic process
IOD25_RS02450	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IOD25_RS02455	COG0163	prenyltransferase activity
IOD25_RS02480	COG4160	amino acid transport
IOD25_RS02485	COG4598	ABC transporter
IOD25_RS02500	COG1090	epimerase
IOD25_RS02505	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IOD25_RS02510	COG0625	glutathione transferase activity
IOD25_RS02515	COG0625	glutathione transferase activity
IOD25_RS02520	COG0622	Phosphoesterase
IOD25_RS02525	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IOD25_RS02530	COG0857	belongs to the CobB CobQ family
IOD25_RS02530	COG0280	phosphate acetyltransferase
IOD25_RS02550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IOD25_RS02555	COG0490	domain, Protein
IOD25_RS02555	COG0471	metal ion transport
IOD25_RS02565	COG0436	Aminotransferase
IOD25_RS02570	COG0583	DNA-binding transcription factor activity
IOD25_RS02615	COG0839	Belongs to the complex I subunit 6 family
IOD25_RS02625	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IOD25_RS02630	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IOD25_RS02645	COG2153	protein acetylation
IOD25_RS02650	COG1169	isochorismate synthase
IOD25_RS02675	COG0318	PFAM AMP-dependent synthetase and ligase
IOD25_RS02685	COG5464	transposase or invertase
IOD25_RS02700	COG1414	Transcriptional regulator
IOD25_RS02720	COG2271	Major facilitator Superfamily
IOD25_RS02730	COG0247	lactate metabolic process
IOD25_RS02740	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IOD25_RS02745	COG2271	Major facilitator Superfamily
IOD25_RS02750	COG0584	glycerophosphoryl diester phosphodiesterase
IOD25_RS02755	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IOD25_RS02780	COG0784	Response regulator, receiver
IOD25_RS02780	COG2205	protein histidine kinase activity
IOD25_RS02790	COG2198	Histidine kinase
IOD25_RS02790	COG0642	Histidine kinase
IOD25_RS02805	COG2169	Transcriptional regulator
IOD25_RS02805	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IOD25_RS02810	COG3145	DNA-N1-methyladenine dioxygenase activity
IOD25_RS02815	COG4615	Cyclic peptide transporter
IOD25_RS02820	COG2239	Acts as a magnesium transporter
IOD25_RS02825	COG0659	secondary active sulfate transmembrane transporter activity
IOD25_RS02840	COG0628	permease
IOD25_RS02865	COG1349	DNA-binding transcription factor activity
IOD25_RS02870	COG0494	nUDIX hydrolase
IOD25_RS02890	COG1061	Type III restriction enzyme res subunit
IOD25_RS02895	COG1187	pseudouridine synthase activity
IOD25_RS02900	COG2814	Major facilitator Superfamily
IOD25_RS02910	COG4172	Belongs to the ABC transporter superfamily
IOD25_RS02915	COG4239	(ABC) transporter, permease
IOD25_RS02920	COG4174	ABC transporter (Permease)
IOD25_RS02925	COG4166	transmembrane transport
IOD25_RS02930	COG2200	EAL domain
IOD25_RS02935	COG0791	NLP P60 protein
IOD25_RS02940	COG0671	phosphoesterase, PA-phosphatase related
IOD25_RS02945	COG0523	cobalamin synthesis protein
IOD25_RS02950	COG0246	Mannitol dehydrogenase
IOD25_RS02955	COG1312	Catalyzes the dehydration of D-mannonate
IOD25_RS02975	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD25_RS02975	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD25_RS02980	COG1105	Belongs to the carbohydrate kinase PfkB family
IOD25_RS02985	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IOD25_RS02985	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IOD25_RS02985	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IOD25_RS02995	COG2855	membrane
IOD25_RS03000	COG0583	DNA-binding transcription factor activity
IOD25_RS03005	COG0833	amino acid
IOD25_RS03010	COG4771	TonB-dependent receptor
IOD25_RS03025	COG2311	Membrane
IOD25_RS03040	COG1129	ABC transporter
IOD25_RS03050	COG2949	membrane
IOD25_RS03060	COG1346	cytolysis
IOD25_RS03070	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IOD25_RS03075	COG3659	wide pore channel activity
IOD25_RS03090	COG2723	6-phospho-beta-galactosidase activity
IOD25_RS03095	COG1538	Outer membrane efflux protein
IOD25_RS03100	COG0586	Pfam SNARE associated Golgi protein
IOD25_RS03110	COG1686	Belongs to the peptidase S11 family
IOD25_RS03125	COG0277	FAD linked oxidase domain protein
IOD25_RS03130	COG1472	Belongs to the glycosyl hydrolase 3 family
IOD25_RS03135	COG1732	Glycine betaine
IOD25_RS03140	COG1174	glycine betaine transport
IOD25_RS03145	COG1125	glycine betaine transport
IOD25_RS03150	COG1174	glycine betaine transport
IOD25_RS03160	COG3275	phosphorelay sensor kinase activity
IOD25_RS03170	COG4807	Protein conserved in bacteria
IOD25_RS03190	COG5455	response to cobalt ion
IOD25_RS03195	COG0583	DNA-binding transcription factor activity
IOD25_RS03200	COG2252	PERMEase
IOD25_RS03210	COG0583	DNA-binding transcription factor activity
IOD25_RS03225	COG0351	phosphomethylpyrimidine kinase
IOD25_RS03230	COG1830	Aldolase
IOD25_RS03240	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IOD25_RS03265	COG1070	Carbohydrate kinase
IOD25_RS03275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IOD25_RS03280	COG4948	Mandelate Racemase Muconate Lactonizing
IOD25_RS03285	COG0747	negative chemotaxis
IOD25_RS03290	COG0601	transmembrane transport
IOD25_RS03295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOD25_RS03300	COG0444	Belongs to the ABC transporter superfamily
IOD25_RS03305	COG4608	Belongs to the ABC transporter superfamily
IOD25_RS03315	COG0826	peptidase U32
IOD25_RS03320	COG0745	RESPONSE REGULATOR receiver
IOD25_RS03325	COG2205	protein histidine kinase activity
IOD25_RS03350	COG1301	dicarboxylic acid transport
IOD25_RS03370	COG5002	protein histidine kinase activity
IOD25_RS03375	COG0443	Heat shock 70 kDa protein
IOD25_RS03380	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IOD25_RS03395	COG2982	Protein involved in outer membrane biogenesis
IOD25_RS03400	COG1253	flavin adenine dinucleotide binding
IOD25_RS03445	COG1215	transferase activity, transferring glycosyl groups
IOD25_RS03475	COG0110	maltose O-acetyltransferase activity
IOD25_RS03505	COG1088	dTDP-glucose 4,6-dehydratase activity
IOD25_RS03565	COG0438	transferase activity, transferring glycosyl groups
IOD25_RS03570	COG1442	glycosyl transferase family 8
IOD25_RS03570	COG1216	Glycosyl transferase, family 2
IOD25_RS03580	COG0463	Glycosyl transferase, family 2
IOD25_RS03605	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IOD25_RS03635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IOD25_RS03640	COG0583	DNA-binding transcription factor activity
IOD25_RS03650	COG0531	amino acid
IOD25_RS03655	COG0640	Transcriptional regulator
IOD25_RS03660	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IOD25_RS03665	COG2925	Exonuclease
IOD25_RS03685	COG1289	transmembrane transporter activity
IOD25_RS03705	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IOD25_RS03715	COG1942	4-Oxalocrotonate Tautomerase
IOD25_RS03720	COG0583	DNA-binding transcription factor activity
IOD25_RS03725	COG0095	Lipoate-protein ligase
IOD25_RS03730	COG0477	Major facilitator Superfamily
IOD25_RS03740	COG5001	Diguanylate cyclase
IOD25_RS03740	COG3300	MHYT domain
IOD25_RS03750	COG3615	Tellurite resistance protein tehB
IOD25_RS03775	COG3706	GGDEF domain
IOD25_RS03795	COG2207	Transcriptional regulator
IOD25_RS03810	COG1566	PFAM secretion protein HlyD family protein
IOD25_RS03815	COG4977	sequence-specific DNA binding
IOD25_RS03840	COG1028	Short-chain dehydrogenase reductase Sdr
IOD25_RS03845	COG2814	Major facilitator Superfamily
IOD25_RS03860	COG1737	Transcriptional regulator
IOD25_RS03875	COG0582	viral genome integration into host DNA
IOD25_RS03885	COG0534	Mate efflux family protein
IOD25_RS03895	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IOD25_RS03915	COG0604	alcohol dehydrogenase
IOD25_RS03920	COG1309	transcriptional regulator
IOD25_RS03930	COG0025	NhaP-type Na H and K H
IOD25_RS04110	COG0582	viral genome integration into host DNA
IOD25_RS04130	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IOD25_RS04140	COG1418	mRNA catabolic process
IOD25_RS04145	COG0270	DNA (cytosine-5-)-methyltransferase activity
IOD25_RS04150	COG3727	T/G mismatch-specific endonuclease activity
IOD25_RS04155	COG0697	spore germination
IOD25_RS04160	COG2354	Protein conserved in bacteria
IOD25_RS04190	COG0366	Alpha amylase catalytic
IOD25_RS04195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD25_RS04205	COG0765	amino acid transport
IOD25_RS04210	COG1126	abc transporter atp-binding protein
IOD25_RS04215	COG2197	response regulator
IOD25_RS04225	COG2197	response regulator
IOD25_RS04260	COG3318	Belongs to the UPF0149 family
IOD25_RS04260	COG3012	SEC-C Motif Domain Protein
IOD25_RS04265	COG0814	amino acid
IOD25_RS04275	COG1528	Iron-storage protein
IOD25_RS04290	COG0477	Major facilitator Superfamily
IOD25_RS04300	COG2211	Major facilitator Superfamily
IOD25_RS04310	COG1528	Iron-storage protein
IOD25_RS04320	COG1879	ABC-type sugar transport system periplasmic component
IOD25_RS04330	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD25_RS04355	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
IOD25_RS04365	COG3102	Protein conserved in bacteria
IOD25_RS04385	COG3788	relative of glutathione S-transferase, MAPEG superfamily
IOD25_RS04390	COG1801	Protein of unknown function DUF72
IOD25_RS04395	COG1335	isochorismatase
IOD25_RS04405	COG0494	nUDIX hydrolase
IOD25_RS04430	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IOD25_RS04440	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
IOD25_RS04445	COG0739	heme binding
IOD25_RS04450	COG1560	Kdo2-lipid A biosynthetic process
IOD25_RS04460	COG1737	Transcriptional regulator
IOD25_RS04470	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IOD25_RS04475	COG0129	dihydroxy-acid dehydratase activity
IOD25_RS04480	COG0800	Aldolase
IOD25_RS04490	COG3141	response to X-ray
IOD25_RS04495	COG2979	Protein of unknown function (DUF533)
IOD25_RS04500	COG1770	oligopeptidase
IOD25_RS04505	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IOD25_RS04515	COG2372	response to copper ion
IOD25_RS04520	COG1276	copper resistance
IOD25_RS04535	COG2990	Protein conserved in bacteria
IOD25_RS04560	COG3008	intermembrane lipid transfer
IOD25_RS04565	COG2995	paraquat-inducible protein a
IOD25_RS04570	COG1956	GAF domain-containing protein
IOD25_RS04590	COG2814	Major facilitator Superfamily
IOD25_RS04595	COG1414	Transcriptional regulator
IOD25_RS04625	COG0768	penicillin binding
IOD25_RS04630	COG2226	methyltransferase
IOD25_RS04645	COG3716	PTS system mannose fructose sorbose family IID component
IOD25_RS04650	COG3715	PTS system
IOD25_RS04655	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IOD25_RS04655	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD25_RS04660	COG1253	flavin adenine dinucleotide binding
IOD25_RS04665	COG2200	EAL domain
IOD25_RS04670	COG1760	l-serine dehydratase
IOD25_RS04690	COG0251	oxidation-reduction process
IOD25_RS04695	COG1199	ATP-dependent helicase activity
IOD25_RS04705	COG3065	identical protein binding
IOD25_RS04715	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IOD25_RS04725	COG2894	cell division
IOD25_RS04740	COG0179	Fumarylacetoacetate (FAA) hydrolase
IOD25_RS04770	COG2719	SpoVR family
IOD25_RS04795	COG1619	proteins homologs of microcin C7 resistance protein MccF
IOD25_RS04820	COG2308	Evidence 4 Homologs of previously reported genes of
IOD25_RS04875	COG0538	isocitrate dehydrogenase activity
IOD25_RS04880	COG0640	Transcriptional regulator
IOD25_RS04900	COG3813	Protein conserved in bacteria
IOD25_RS04905	COG1063	alcohol dehydrogenase
IOD25_RS04910	COG3729	General stress protein
IOD25_RS04915	COG3685	Protein conserved in bacteria
IOD25_RS04920	COG3685	Protein conserved in bacteria
IOD25_RS04925	COG3546	catalase activity
IOD25_RS04930	COG1271	oxidase subunit
IOD25_RS04935	COG1294	oxidase, subunit
IOD25_RS04965	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IOD25_RS04970	COG0583	DNA-binding transcription factor activity
IOD25_RS04975	COG3706	GGDEF domain
IOD25_RS04980	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IOD25_RS04990	COG1560	Kdo2-lipid A biosynthetic process
IOD25_RS05000	COG3182	Iron-regulated membrane protein
IOD25_RS05020	COG2199	diguanylate cyclase activity
IOD25_RS05020	COG2203	Gaf domain
IOD25_RS05025	COG3042	response to heat
IOD25_RS05030	COG3189	MarR family transcriptional regulator
IOD25_RS05035	COG1683	Conserved Protein
IOD25_RS05040	COG0504	CTP synthase activity
IOD25_RS05045	COG2807	transmembrane transport
IOD25_RS05050	COG2207	Transcriptional regulator
IOD25_RS05060	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IOD25_RS05065	COG0859	PFAM glycosyl transferase family 9
IOD25_RS05080	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IOD25_RS05085	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IOD25_RS05090	COG0583	DNA-binding transcription factor activity
IOD25_RS05095	COG1028	Short-chain dehydrogenase reductase Sdr
IOD25_RS05120	COG0386	Belongs to the glutathione peroxidase family
IOD25_RS05135	COG2766	serine protein kinase
IOD25_RS05140	COG3713	MltA-interacting MipA family protein
IOD25_RS05145	COG0656	L-ascorbic acid biosynthetic process
IOD25_RS05165	COG3139	Protein of unknown function (DUF1315)
IOD25_RS05180	COG1063	alcohol dehydrogenase
IOD25_RS05185	COG2271	Major facilitator Superfamily
IOD25_RS05205	COG0191	fructose-bisphosphate aldolase activity
IOD25_RS05210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOD25_RS05215	COG0667	Aldo Keto reductase
IOD25_RS05220	COG1349	DNA-binding transcription factor activity
IOD25_RS05245	COG1335	isochorismatase
IOD25_RS05250	COG0252	asparaginase activity
IOD25_RS05255	COG0616	signal peptide processing
IOD25_RS05260	COG0778	Nitroreductase
IOD25_RS05270	COG0709	Synthesizes selenophosphate from selenide and ATP
IOD25_RS05275	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IOD25_RS05280	COG1028	Short-chain dehydrogenase reductase Sdr
IOD25_RS05280	COG0604	alcohol dehydrogenase
IOD25_RS05280	COG3321	synthase
IOD25_RS05285	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IOD25_RS05290	COG0494	nUDIX hydrolase
IOD25_RS05295	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IOD25_RS05300	COG2897	thiosulfate sulfurtransferase activity
IOD25_RS05305	COG4136	ATPase activity
IOD25_RS05310	COG4135	transport system, permease component
IOD25_RS05320	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IOD25_RS05325	COG0398	Pfam SNARE associated Golgi protein
IOD25_RS05330	COG0398	Pfam SNARE associated Golgi protein
IOD25_RS05335	COG0708	Exodeoxyribonuclease III
IOD25_RS05345	COG3138	arginine N-succinyltransferase
IOD25_RS05355	COG3724	N-succinylarginine dihydrolase activity
IOD25_RS05365	COG3678	ATP-independent chaperone mediated protein folding
IOD25_RS05370	COG0322	excinuclease ABC activity
IOD25_RS05380	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IOD25_RS05385	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IOD25_RS05395	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IOD25_RS05400	COG1447	Phosphotransferase system cellobiose-specific component IIA
IOD25_RS05405	COG1917	Cupin 2, conserved barrel domain protein
IOD25_RS05405	COG2169	Transcriptional regulator
IOD25_RS05410	COG1486	melibiose metabolic process
IOD25_RS05430	COG1823	symporter activity
IOD25_RS05435	COG1988	membrane-bound metal-dependent
IOD25_RS05440	COG1028	Short-chain dehydrogenase reductase Sdr
IOD25_RS05445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IOD25_RS05475	COG0727	PFAM Uncharacterised protein family (UPF0153)
IOD25_RS05480	COG3047	cAMP biosynthetic process
IOD25_RS05490	COG4774	siderophore transport
IOD25_RS05525	COG0135	phosphoribosylanthranilate isomerase activity
IOD25_RS05525	COG0134	indole-3-glycerol-phosphate synthase activity
IOD25_RS05530	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IOD25_RS05530	COG0512	Glutamine amidotransferase of anthranilate synthase
IOD25_RS05535	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IOD25_RS05545	COG0009	L-threonylcarbamoyladenylate synthase
IOD25_RS05555	COG0583	DNA-binding transcription factor activity
IOD25_RS05565	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
IOD25_RS05570	COG1028	Short-chain dehydrogenase reductase Sdr
IOD25_RS05580	COG0616	signal peptide processing
IOD25_RS05605	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IOD25_RS05615	COG0671	phosphoesterase, PA-phosphatase related
IOD25_RS05620	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
IOD25_RS05625	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IOD25_RS05635	COG0023	Translation Initiation Factor
IOD25_RS05645	COG1349	DNA-binding transcription factor activity
IOD25_RS05660	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IOD25_RS05660	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IOD25_RS05665	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IOD25_RS05675	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IOD25_RS05690	COG4171	peptide transport system, permease
IOD25_RS05725	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IOD25_RS05765	COG1846	Transcriptional regulator
IOD25_RS05845	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
IOD25_RS05850	COG0484	heat shock protein binding
IOD25_RS05895	COG3728	DNA packaging
IOD25_RS05895	COG5484	DNA packaging
IOD25_RS05985	COG1196	nuclear chromosome segregation
IOD25_RS06040	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IOD25_RS06045	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IOD25_RS06055	COG2135	peptidase activity
IOD25_RS06070	COG0702	epimerase
IOD25_RS06085	COG1473	amidohydrolase
IOD25_RS06095	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IOD25_RS06100	COG1842	Phage shock protein A
IOD25_RS06110	COG1983	PspC domain protein
IOD25_RS06120	COG3106	COG3106 Predicted ATPase
IOD25_RS06130	COG0583	DNA-binding transcription factor activity
IOD25_RS06135	COG1486	melibiose metabolic process
IOD25_RS06145	COG3180	Ammonia monooxygenase
IOD25_RS06150	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IOD25_RS06155	COG4948	Mandelate Racemase Muconate Lactonizing
IOD25_RS06160	COG2866	Carboxypeptidase
IOD25_RS06170	COG4166	transmembrane transport
IOD25_RS06195	COG0656	L-ascorbic acid biosynthetic process
IOD25_RS06210	COG0583	DNA-binding transcription factor activity
IOD25_RS06215	COG1028	Short-chain dehydrogenase reductase Sdr
IOD25_RS06235	COG2011	ABC-type metal ion transport system permease component
IOD25_RS06250	COG0673	inositol 2-dehydrogenase activity
IOD25_RS06255	COG1349	DNA-binding transcription factor activity
IOD25_RS06265	COG0513	Belongs to the DEAD box helicase family
IOD25_RS06275	COG0589	response to stress
IOD25_RS06300	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IOD25_RS06300	COG0674	pyruvate-flavodoxin oxidoreductase activity
IOD25_RS06300	COG1013	pyruvate-flavodoxin oxidoreductase activity
IOD25_RS06300	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IOD25_RS06305	COG3042	response to heat
IOD25_RS06310	COG3187	Heat shock protein
IOD25_RS06315	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IOD25_RS06320	COG0586	Pfam SNARE associated Golgi protein
IOD25_RS06325	COG2911	Protein conserved in bacteria
IOD25_RS06335	COG3784	Protein of unknown function (DUF1318)
IOD25_RS06340	COG2207	Transcriptional regulator
IOD25_RS06345	COG1012	belongs to the aldehyde dehydrogenase family
IOD25_RS06360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD25_RS06370	COG1126	abc transporter atp-binding protein
IOD25_RS06375	COG0583	DNA-binding transcription factor activity
IOD25_RS06380	COG2072	flavoprotein involved in K transport
IOD25_RS06395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IOD25_RS06415	COG2030	dehydratase
IOD25_RS06415	COG1012	belongs to the aldehyde dehydrogenase family
IOD25_RS06420	COG3396	Phenylacetate-CoA oxygenase
IOD25_RS06425	COG3460	Phenylacetate-CoA oxygenase
IOD25_RS06430	COG3396	Phenylacetate-CoA oxygenase
IOD25_RS06435	COG2151	metal-sulfur cluster biosynthetic enzyme
IOD25_RS06440	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IOD25_RS06445	COG1024	Enoyl-CoA hydratase
IOD25_RS06450	COG1024	Enoyl-CoA hydratase
IOD25_RS06455	COG1250	3-hydroxyacyl-CoA dehydrogenase
IOD25_RS06460	COG2050	protein possibly involved in aromatic compounds catabolism
IOD25_RS06465	COG0183	Belongs to the thiolase family
IOD25_RS06470	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
IOD25_RS06475	COG3327	negative regulation of DNA-templated transcription, initiation
IOD25_RS06480	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IOD25_RS06495	COG1643	Atp-dependent helicase
IOD25_RS06500	COG4122	O-methyltransferase activity
IOD25_RS06525	COG0583	DNA-binding transcription factor activity
IOD25_RS06530	COG0667	Aldo Keto reductase
IOD25_RS06535	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IOD25_RS06545	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IOD25_RS06550	COG3138	arginine N-succinyltransferase
IOD25_RS06555	COG1012	belongs to the aldehyde dehydrogenase family
IOD25_RS06560	COG3724	N-succinylarginine dihydrolase activity
IOD25_RS06565	COG2988	succinylglutamate desuccinylase activity
IOD25_RS06570	COG1113	amino acid transport
IOD25_RS06580	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IOD25_RS06590	COG1012	belongs to the aldehyde dehydrogenase family
IOD25_RS06595	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IOD25_RS06600	COG0401	homolog of Blt101
IOD25_RS06605	COG5562	phage envelope protein
IOD25_RS06610	COG0425	Belongs to the sulfur carrier protein TusA family
IOD25_RS06615	COG2391	methyltransferase activity
IOD25_RS06640	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IOD25_RS06645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IOD25_RS06645	COG1263	PTS System
IOD25_RS06650	COG1609	Transcriptional regulator
IOD25_RS06655	COG5339	Protein conserved in bacteria
IOD25_RS06660	COG1482	cell wall glycoprotein biosynthetic process
IOD25_RS06665	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IOD25_RS06665	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IOD25_RS06675	COG0114	fumarate hydratase activity
IOD25_RS06685	COG2205	protein histidine kinase activity
IOD25_RS06695	COG0745	RESPONSE REGULATOR receiver
IOD25_RS06700	COG3136	membrane protein required for alginate biosynthesis
IOD25_RS06710	COG0531	amino acid
IOD25_RS06725	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IOD25_RS06730	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IOD25_RS06745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IOD25_RS06760	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IOD25_RS06765	COG1473	amidohydrolase
IOD25_RS06775	COG0583	DNA-binding transcription factor activity
IOD25_RS06780	COG2840	Smr protein MutS2
IOD25_RS06785	COG1414	Transcriptional regulator
IOD25_RS06795	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IOD25_RS06800	COG0183	Belongs to the thiolase family
IOD25_RS06810	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IOD25_RS06815	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IOD25_RS06825	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IOD25_RS06825	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IOD25_RS06845	COG4565	transcriptional regulatory protein
IOD25_RS06850	COG3290	protein histidine kinase activity
IOD25_RS06875	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IOD25_RS06885	COG0679	Auxin Efflux Carrier
IOD25_RS06915	COG0628	permease
IOD25_RS06935	COG3591	Belongs to the peptidase S1B family
IOD25_RS06945	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
IOD25_RS06950	COG2814	Major facilitator Superfamily
IOD25_RS06955	COG0583	DNA-binding transcription factor activity
IOD25_RS06960	COG1940	carbohydrate kinase activity
IOD25_RS06965	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IOD25_RS06980	COG3302	dmso reductase anchor subunit
IOD25_RS06985	COG0437	4 iron, 4 sulfur cluster binding
IOD25_RS06990	COG0243	molybdopterin cofactor binding
IOD25_RS07005	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IOD25_RS07020	COG2271	Major facilitator Superfamily
IOD25_RS07025	COG0246	Mannitol dehydrogenase
IOD25_RS07030	COG0589	response to stress
IOD25_RS07035	COG1802	Transcriptional regulator
IOD25_RS07040	COG4221	oxidoreductase activity
IOD25_RS07055	COG2207	Transcriptional regulator
IOD25_RS07060	COG2135	peptidase activity
IOD25_RS07075	COG2197	response regulator
IOD25_RS07095	COG0071	Belongs to the small heat shock protein (HSP20) family
IOD25_RS07100	COG1546	Belongs to the CinA family
IOD25_RS07105	COG2200	EAL domain
IOD25_RS07120	COG3708	Transcriptional regulator
IOD25_RS07120	COG2207	Transcriptional regulator
IOD25_RS07125	COG2610	gluconate transmembrane transporter activity
IOD25_RS07130	COG3622	Belongs to the hyi family
IOD25_RS07135	COG0235	Class ii aldolase
IOD25_RS07140	COG3395	kinase activity
IOD25_RS07145	COG2084	Dehydrogenase
IOD25_RS07150	COG1349	DNA-binding transcription factor activity
IOD25_RS07165	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IOD25_RS07170	COG2223	nitrite transmembrane transporter activity
IOD25_RS07205	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IOD25_RS07210	COG0683	leucine binding
IOD25_RS07225	COG1129	ABC transporter
IOD25_RS07240	COG2814	Major facilitator Superfamily
IOD25_RS07245	COG0697	spore germination
IOD25_RS07255	COG4977	sequence-specific DNA binding
IOD25_RS07295	COG0039	L-malate dehydrogenase activity
IOD25_RS07305	COG0583	DNA-binding transcription factor activity
IOD25_RS07310	COG1012	belongs to the aldehyde dehydrogenase family
IOD25_RS07325	COG2199	diguanylate cyclase activity
IOD25_RS07375	COG0477	Major facilitator Superfamily
IOD25_RS07385	COG2070	2-Nitropropane dioxygenase
IOD25_RS07390	COG2011	ABC-type metal ion transport system permease component
IOD25_RS07410	COG4628	conserved protein (DUF2132)
IOD25_RS07425	COG2207	Transcriptional regulator
IOD25_RS07455	COG2233	PERMEase
IOD25_RS07465	COG2351	hydroxyisourate hydrolase activity
IOD25_RS07470	COG1396	sequence-specific DNA binding
IOD25_RS07475	COG3550	peptidyl-serine autophosphorylation
IOD25_RS07480	COG1649	PFAM Uncharacterised BCR, COG1649
IOD25_RS07490	COG3188	usher protein
IOD25_RS07525	COG5001	Diguanylate cyclase
IOD25_RS07525	COG3300	MHYT domain
IOD25_RS07530	COG2819	hydrolase of the alpha beta superfamily
IOD25_RS07545	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD25_RS07545	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD25_RS07550	COG2814	Major facilitator Superfamily
IOD25_RS07560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IOD25_RS07560	COG1263	PTS System
IOD25_RS07565	COG2186	Transcriptional regulator
IOD25_RS07585	COG3835	regulator
IOD25_RS07590	COG1929	Belongs to the glycerate kinase type-1 family
IOD25_RS07635	COG0738	Major facilitator superfamily
IOD25_RS07640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOD25_RS07645	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IOD25_RS07650	COG1349	DNA-binding transcription factor activity
IOD25_RS07660	COG1070	Carbohydrate kinase
IOD25_RS07665	COG1349	DNA-binding transcription factor activity
IOD25_RS07685	COG0667	Aldo Keto reductase
IOD25_RS07690	COG3386	PFAM SMP-30 Gluconolaconase
IOD25_RS07695	COG0667	Aldo Keto reductase
IOD25_RS07700	COG0667	Aldo Keto reductase
IOD25_RS07710	COG0456	acetyltransferase
IOD25_RS07710	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
IOD25_RS07735	COG1652	LysM domain
IOD25_RS07765	COG1609	Transcriptional regulator
IOD25_RS07775	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD25_RS07790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IOD25_RS07800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IOD25_RS07805	COG0583	DNA-binding transcription factor activity
IOD25_RS07810	COG0583	DNA-binding transcription factor activity
IOD25_RS07825	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IOD25_RS07825	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IOD25_RS07825	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IOD25_RS07830	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IOD25_RS07840	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IOD25_RS07855	COG2223	nitrite transmembrane transporter activity
IOD25_RS07880	COG1902	pentaerythritol trinitrate reductase activity
IOD25_RS07890	COG0583	DNA-binding transcription factor activity
IOD25_RS07895	COG2070	2-Nitropropane dioxygenase
IOD25_RS07905	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IOD25_RS07915	COG0765	amino acid transport
IOD25_RS07975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IOD25_RS07990	COG2207	Transcriptional regulator
IOD25_RS08005	COG1335	isochorismatase
IOD25_RS08010	COG0406	alpha-ribazole phosphatase activity
IOD25_RS08055	COG1953	Uracil, thiamine, allantoin
IOD25_RS08060	COG0402	S-adenosylhomocysteine deaminase activity
IOD25_RS08065	COG3706	GGDEF domain
IOD25_RS08070	COG1609	Transcriptional regulator
IOD25_RS08080	COG0673	inositol 2-dehydrogenase activity
IOD25_RS08095	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IOD25_RS08100	COG1116	anion transmembrane transporter activity
IOD25_RS08105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IOD25_RS08110	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IOD25_RS08115	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IOD25_RS08120	COG0076	glutamate decarboxylase activity
IOD25_RS08140	COG2205	protein histidine kinase activity
IOD25_RS08150	COG0596	Alpha beta hydrolase
IOD25_RS08190	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IOD25_RS08190	COG0519	Catalyzes the synthesis of GMP from XMP
IOD25_RS08210	COG0583	DNA-binding transcription factor activity
IOD25_RS08220	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IOD25_RS08225	COG1285	pathogenesis
IOD25_RS08230	COG2814	Major facilitator Superfamily
IOD25_RS08235	COG0583	DNA-binding transcription factor activity
IOD25_RS08240	COG0243	molybdopterin cofactor binding
IOD25_RS08265	COG1764	response to oxidative stress
IOD25_RS08275	COG3111	PFAM Bacterial OB fold (BOF) protein
IOD25_RS08285	COG2323	membrane
IOD25_RS08295	COG0366	Alpha amylase catalytic
IOD25_RS08305	COG3685	Protein conserved in bacteria
IOD25_RS08315	COG3729	General stress protein
IOD25_RS08320	COG1028	Short-chain dehydrogenase reductase Sdr
IOD25_RS08365	COG0488	(ABC) transporter
IOD25_RS08380	COG1064	alcohol dehydrogenase
IOD25_RS08385	COG0747	negative chemotaxis
IOD25_RS08395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOD25_RS08405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD25_RS08415	COG2814	Major facilitator Superfamily
IOD25_RS08425	COG2326	polyphosphate kinase activity
IOD25_RS08440	COG2864	formate dehydrogenase
IOD25_RS08445	COG0437	4 iron, 4 sulfur cluster binding
IOD25_RS08470	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
IOD25_RS08480	COG3485	protocatechuate 3,4-dioxygenase
IOD25_RS08485	COG4829	muconolactone delta-isomerase
IOD25_RS08490	COG4948	Mandelate Racemase Muconate Lactonizing
IOD25_RS08495	COG1414	Transcriptional regulator
IOD25_RS08515	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IOD25_RS08520	COG1140	nitrate reductase beta subunit
IOD25_RS08525	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
IOD25_RS08530	COG2181	nitrate reductase activity
IOD25_RS08535	COG2162	N-hydroxyarylamine O-acetyltransferase activity
IOD25_RS08540	COG1178	ABC-type Fe3 transport system permease component
IOD25_RS08545	COG1840	ABC-type Fe3 transport system, periplasmic component
IOD25_RS08550	COG3842	ATPase activity
IOD25_RS08555	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IOD25_RS08565	COG0625	glutathione transferase activity
IOD25_RS08575	COG1126	abc transporter atp-binding protein
IOD25_RS08580	COG0765	amino acid transport
IOD25_RS08590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD25_RS08595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD25_RS08610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD25_RS08615	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IOD25_RS08640	COG4772	TonB-dependent receptor
IOD25_RS08645	COG1228	amidohydrolase
IOD25_RS08650	COG3691	Protein conserved in bacteria
IOD25_RS08665	COG2130	NADP-dependent
IOD25_RS08675	COG1247	-acetyltransferase
IOD25_RS08680	COG3238	Protein conserved in bacteria
IOD25_RS08690	COG0747	negative chemotaxis
IOD25_RS08695	COG1012	belongs to the aldehyde dehydrogenase family
IOD25_RS08730	COG1012	belongs to the aldehyde dehydrogenase family
IOD25_RS08735	COG1177	transmembrane transport
IOD25_RS08740	COG1176	ABC-type spermidine putrescine transport system, permease component I
IOD25_RS08745	COG3842	ATPase activity
IOD25_RS08750	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IOD25_RS08755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOD25_RS08765	COG1271	oxidase subunit
IOD25_RS08770	COG1294	oxidase, subunit
IOD25_RS08790	COG0826	peptidase U32
IOD25_RS08800	COG1396	sequence-specific DNA binding
IOD25_RS08805	COG3135	benzoate transporter
IOD25_RS08810	COG2207	Transcriptional regulator
IOD25_RS08810	COG3708	Transcriptional regulator
IOD25_RS08815	COG0697	spore germination
IOD25_RS08825	COG0500	methyltransferase
IOD25_RS08830	COG1275	C4-dicarboxylate transporter malic acid transport protein
IOD25_RS08835	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IOD25_RS08840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IOD25_RS08855	COG2272	Belongs to the type-B carboxylesterase lipase family
IOD25_RS08860	COG5383	Protein conserved in bacteria
IOD25_RS08865	COG3485	protocatechuate 3,4-dioxygenase
IOD25_RS08870	COG3485	protocatechuate 3,4-dioxygenase
IOD25_RS08875	COG0583	DNA-binding transcription factor activity
IOD25_RS08895	COG3038	cytochrome b561
IOD25_RS08915	COG2814	Major facilitator Superfamily
IOD25_RS08925	COG0673	inositol 2-dehydrogenase activity
IOD25_RS08935	COG2723	6-phospho-beta-galactosidase activity
IOD25_RS08970	COG4659	FMN binding
IOD25_RS08980	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IOD25_RS08990	COG0625	glutathione transferase activity
IOD25_RS08995	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IOD25_RS09010	COG3895	Periplasmic Protein
IOD25_RS09025	COG3706	GGDEF domain
IOD25_RS09040	COG1566	PFAM secretion protein HlyD family protein
IOD25_RS09045	COG1289	transmembrane transporter activity
IOD25_RS09050	COG2032	superoxide dismutase activity
IOD25_RS09055	COG4989	oxidoreductase activity
IOD25_RS09060	COG3313	Fe-S protein
IOD25_RS09065	COG1309	transcriptional regulator
IOD25_RS09070	COG1902	pentaerythritol trinitrate reductase activity
IOD25_RS09075	COG0346	lactoylglutathione lyase activity
IOD25_RS09085	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IOD25_RS09090	COG0791	NLP P60 protein
IOD25_RS09150	COG2814	Major facilitator Superfamily
IOD25_RS09165	COG0583	DNA-binding transcription factor activity
IOD25_RS09170	COG2814	Major facilitator Superfamily
IOD25_RS09175	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IOD25_RS09180	COG0307	riboflavin synthase, alpha
IOD25_RS09230	COG0300	oxidoreductase activity
IOD25_RS09250	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IOD25_RS09285	COG1349	DNA-binding transcription factor activity
IOD25_RS09290	COG0346	lactoylglutathione lyase activity
IOD25_RS09315	COG0444	Belongs to the ABC transporter superfamily
IOD25_RS09320	COG4608	Belongs to the ABC transporter superfamily
IOD25_RS09345	COG0583	DNA-binding transcription factor activity
IOD25_RS09375	COG0402	S-adenosylhomocysteine deaminase activity
IOD25_RS09400	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IOD25_RS09405	COG0277	FAD linked oxidase domain protein
IOD25_RS09420	COG2814	Major facilitator Superfamily
IOD25_RS09450	COG0583	DNA-binding transcription factor activity
IOD25_RS09460	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IOD25_RS09470	COG1250	3-hydroxyacyl-CoA dehydrogenase
IOD25_RS09475	COG2610	gluconate transmembrane transporter activity
IOD25_RS09480	COG1028	Short-chain dehydrogenase reductase Sdr
IOD25_RS09510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IOD25_RS09525	COG0745	RESPONSE REGULATOR receiver
IOD25_RS09530	COG5002	protein histidine kinase activity
IOD25_RS09530	COG3850	Histidine kinase
IOD25_RS09550	COG3088	subunit of a heme lyase
IOD25_RS09550	COG4235	cytochrome complex assembly
IOD25_RS09555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IOD25_RS09560	COG1138	Cytochrome C-type biogenesis protein
IOD25_RS09575	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IOD25_RS09580	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IOD25_RS09585	COG4133	protoheme IX ABC transporter activity
IOD25_RS09615	COG1175	transmembrane transport
IOD25_RS09625	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IOD25_RS09630	COG3383	formate dehydrogenase (NAD+) activity
IOD25_RS09670	COG1126	abc transporter atp-binding protein
IOD25_RS09675	COG0765	amino acid transport
IOD25_RS09695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOD25_RS09700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOD25_RS09705	COG1120	ATPase activity
IOD25_RS09710	COG4774	siderophore transport
IOD25_RS09715	COG1116	anion transmembrane transporter activity
IOD25_RS09720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IOD25_RS09740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD25_RS09745	COG0583	DNA-binding transcription factor activity
IOD25_RS09765	COG2814	Major facilitator Superfamily
IOD25_RS09800	COG1414	Transcriptional regulator
IOD25_RS09805	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IOD25_RS09810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOD25_RS09815	COG1120	ATPase activity
IOD25_RS09825	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IOD25_RS09830	COG2271	Major facilitator Superfamily
IOD25_RS09835	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IOD25_RS09835	COG1082	Xylose isomerase domain protein TIM barrel
IOD25_RS09840	COG1309	transcriptional regulator
IOD25_RS09870	COG1376	ErfK ybiS ycfS ynhG family protein
IOD25_RS09885	COG0719	Fe-S assembly protein
IOD25_RS09890	COG0396	ATPase activity
IOD25_RS09895	COG0719	Fe-S assembly protein
IOD25_RS09900	COG0316	Belongs to the HesB IscA family
IOD25_RS09920	COG1309	transcriptional regulator
IOD25_RS09925	COG1304	FMN binding
IOD25_RS09950	COG0583	DNA-binding transcription factor activity
IOD25_RS09960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOD25_RS09965	COG1120	ATPase activity
IOD25_RS09990	COG2261	transglycosylase associated protein
IOD25_RS09995	COG2050	protein possibly involved in aromatic compounds catabolism
IOD25_RS10000	COG0277	FAD linked oxidase domain protein
IOD25_RS10000	COG0247	lactate metabolic process
IOD25_RS10005	COG0628	permease
IOD25_RS10015	COG0574	Belongs to the PEP-utilizing enzyme family
IOD25_RS10015	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IOD25_RS10030	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IOD25_RS10035	COG4256	Hemin uptake protein
IOD25_RS10045	COG0791	NLP P60 protein
IOD25_RS10055	COG0386	Belongs to the glutathione peroxidase family
IOD25_RS10075	COG0583	DNA-binding transcription factor activity
IOD25_RS10095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IOD25_RS10095	COG0072	phenylalanine-tRNA ligase activity
IOD25_RS10135	COG3137	Salt-induced outer membrane protein
IOD25_RS10140	COG1105	Belongs to the carbohydrate kinase PfkB family
IOD25_RS10150	COG3001	Fructosamine kinase
IOD25_RS10160	COG2350	Protein conserved in bacteria
IOD25_RS10170	COG2353	YceI-like domain
IOD25_RS10190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IOD25_RS10200	COG0444	Belongs to the ABC transporter superfamily
IOD25_RS10205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOD25_RS10210	COG0601	transmembrane transport
IOD25_RS10215	COG4166	transmembrane transport
IOD25_RS10220	COG2095	MarC family integral membrane protein
IOD25_RS10230	COG1012	belongs to the aldehyde dehydrogenase family
IOD25_RS10230	COG1454	alcohol dehydrogenase
IOD25_RS10235	COG1435	thymidine kinase activity
IOD25_RS10245	COG2916	Histone family protein nucleoid-structuring protein H-NS
IOD25_RS10250	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IOD25_RS10255	COG0745	RESPONSE REGULATOR receiver
IOD25_RS10260	COG1752	Esterase of the alpha-beta hydrolase superfamily
IOD25_RS10270	COG0788	formyltetrahydrofolate deformylase activity
IOD25_RS10295	COG1522	sequence-specific DNA binding
IOD25_RS10305	COG2181	nitrate reductase activity
IOD25_RS10310	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
IOD25_RS10315	COG1140	nitrate reductase beta subunit
IOD25_RS10320	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IOD25_RS10330	COG2223	nitrite transmembrane transporter activity
IOD25_RS10335	COG3850	Histidine kinase
IOD25_RS10340	COG2197	response regulator
IOD25_RS10345	COG4932	domain protein
IOD25_RS10350	COG0243	molybdopterin cofactor binding
IOD25_RS10355	COG2146	nitrite reductase [NAD(P)H] activity
IOD25_RS10355	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IOD25_RS10360	COG1116	anion transmembrane transporter activity
IOD25_RS10370	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IOD25_RS10375	COG3707	response regulator
IOD25_RS10380	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
IOD25_RS10390	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
IOD25_RS10395	COG4572	Cation transport regulator
IOD25_RS10400	COG0387	Pfam Sodium calcium exchanger
IOD25_RS10420	COG2890	protein-(glutamine-N5) methyltransferase activity
IOD25_RS10450	COG0659	secondary active sulfate transmembrane transporter activity
IOD25_RS10470	COG0012	GTP binding
IOD25_RS10495	COG3122	Protein conserved in bacteria
IOD25_RS10510	COG0583	DNA-binding transcription factor activity
IOD25_RS10540	COG0583	DNA-binding transcription factor activity
IOD25_RS10575	COG1882	Formate acetyltransferase
IOD25_RS10590	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IOD25_RS10605	COG0538	isocitrate dehydrogenase activity
IOD25_RS10610	COG1187	pseudouridine synthase activity
IOD25_RS10630	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IOD25_RS10650	COG2205	protein histidine kinase activity
IOD25_RS10655	COG2850	peptidyl-arginine hydroxylation
IOD25_RS10680	COG1177	transmembrane transport
IOD25_RS10695	COG0318	PFAM AMP-dependent synthetase and ligase
IOD25_RS10700	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IOD25_RS10705	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IOD25_RS10710	COG0698	ribose 5-phosphate isomerase
IOD25_RS10725	COG3395	kinase activity
IOD25_RS10740	COG2390	Transcriptional regulator
IOD25_RS10750	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IOD25_RS10760	COG4591	ABC-type transport system involved in lipoprotein release permease component
IOD25_RS10770	COG4591	ABC-type transport system involved in lipoprotein release permease component
IOD25_RS10780	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IOD25_RS10785	COG1376	ErfK ybiS ycfS ynhG family protein
IOD25_RS10785	COG1388	LysM domain
IOD25_RS10800	COG1309	transcriptional regulator
IOD25_RS10815	COG3134	Outer membrane lipoprotein
IOD25_RS10820	COG1252	NADH dehydrogenase
IOD25_RS10845	COG5633	Lipoprotein
IOD25_RS10850	COG0537	adenosine 5'-monophosphoramidase activity
IOD25_RS10860	COG0084	hydrolase, TatD family'
IOD25_RS10865	COG0470	DNA polymerase III
IOD25_RS10875	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IOD25_RS10880	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IOD25_RS10885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IOD25_RS10900	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IOD25_RS10920	COG1399	metal-binding, possibly nucleic acid-binding protein
IOD25_RS10940	COG1530	ribonuclease E activity
IOD25_RS10945	COG0583	DNA-binding transcription factor activity
IOD25_RS10950	COG2814	Major facilitator Superfamily
IOD25_RS10970	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IOD25_RS11015	COG1560	Kdo2-lipid A biosynthetic process
IOD25_RS11030	COG5645	(Lipo)protein
IOD25_RS11065	COG3381	protein complex oligomerization
IOD25_RS11100	COG1309	transcriptional regulator
IOD25_RS11105	COG0583	DNA-binding transcription factor activity
IOD25_RS11115	COG1335	isochorismatase
IOD25_RS11125	COG1702	phosphate starvation-inducible protein PhoH
IOD25_RS11145	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IOD25_RS11155	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IOD25_RS11170	COG1309	transcriptional regulator
IOD25_RS11205	COG2233	PERMEase
IOD25_RS11215	COG3729	General stress protein
IOD25_RS11240	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IOD25_RS11375	COG4695	Portal protein
IOD25_RS11465	COG1028	Short-chain dehydrogenase reductase Sdr
IOD25_RS11480	COG0531	amino acid
IOD25_RS11485	COG0174	glutamine synthetase
IOD25_RS11490	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IOD25_RS11495	COG1917	Cupin 2, conserved barrel domain protein
IOD25_RS11495	COG1396	sequence-specific DNA binding
IOD25_RS11500	COG1012	belongs to the aldehyde dehydrogenase family
IOD25_RS11505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IOD25_RS11510	COG0583	DNA-binding transcription factor activity
IOD25_RS11520	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IOD25_RS11525	COG4638	Rieske (2fe-2S)
IOD25_RS11530	COG1012	belongs to the aldehyde dehydrogenase family
IOD25_RS11535	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IOD25_RS11560	COG0670	Belongs to the BI1 family
IOD25_RS11575	COG2207	Transcriptional regulator
IOD25_RS11580	COG1881	PFAM PEBP family protein
IOD25_RS11595	COG1832	CoA-binding protein
IOD25_RS11605	COG0210	DNA helicase
IOD25_RS11610	COG3304	Inner membrane component domain
IOD25_RS11615	COG1289	transmembrane transporter activity
IOD25_RS11620	COG3070	regulator of competence-specific genes
IOD25_RS11640	COG1067	ATP-dependent peptidase activity
IOD25_RS11650	COG3130	regulation of translation
IOD25_RS11655	COG3009	Protein conserved in bacteria
IOD25_RS11660	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IOD25_RS11660	COG3008	intermembrane lipid transfer
IOD25_RS11665	COG2995	paraquat-inducible protein a
IOD25_RS11670	COG0488	(ABC) transporter
IOD25_RS11680	COG0633	Ferredoxin
IOD25_RS11680	COG3217	Mosc domain protein beta barrel domain protein
IOD25_RS11695	COG0431	NADPH-dependent FMN reductase
IOD25_RS11700	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IOD25_RS11705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD25_RS11710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IOD25_RS11720	COG0308	aminopeptidase N
IOD25_RS11730	COG1473	amidohydrolase
IOD25_RS11740	COG0814	amino acid
IOD25_RS11760	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IOD25_RS11765	COG1448	Aminotransferase
IOD25_RS11770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IOD25_RS11775	COG3108	Peptidase M15
IOD25_RS11780	COG2989	Protein conserved in bacteria
IOD25_RS11790	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
IOD25_RS11800	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IOD25_RS11805	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IOD25_RS11810	COG3173	Aminoglycoside phosphotransferase
IOD25_RS11825	COG3214	Protein conserved in bacteria
IOD25_RS11840	COG0658	competence protein
IOD25_RS11840	COG2333	competence protein COMEC
IOD25_RS11850	COG0539	negative regulation of cytoplasmic translation
IOD25_RS11870	COG2323	membrane
IOD25_RS11875	COG1944	ATP diphosphatase activity
IOD25_RS11880	COG2116	formate transmembrane transporter activity
IOD25_RS11885	COG1882	Formate acetyltransferase
IOD25_RS11890	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IOD25_RS11895	COG0477	Major facilitator Superfamily
IOD25_RS11900	COG3302	dmso reductase anchor subunit
IOD25_RS11905	COG0437	4 iron, 4 sulfur cluster binding
IOD25_RS11910	COG0243	molybdopterin cofactor binding
IOD25_RS11920	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IOD25_RS11930	COG1178	ABC-type Fe3 transport system permease component
IOD25_RS11930	COG1674	ftsk spoiiie
IOD25_RS11940	COG0492	ferredoxin-NADP+ reductase activity
IOD25_RS11945	COG4988	ABC transporter
IOD25_RS11950	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IOD25_RS11965	COG0542	response to heat
IOD25_RS11975	COG1278	Cold shock
IOD25_RS11985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOD25_RS11990	COG3593	DNA synthesis involved in DNA repair
IOD25_RS12000	COG2431	L-lysine efflux transmembrane transporter activity
IOD25_RS12010	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IOD25_RS12020	COG0028	Belongs to the TPP enzyme family
IOD25_RS12025	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
IOD25_RS12030	COG0702	epimerase
IOD25_RS12035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IOD25_RS12040	COG3023	N-Acetylmuramoyl-L-alanine amidase
IOD25_RS12045	COG4251	negative regulation of phosphorylation
IOD25_RS12045	COG5001	Diguanylate cyclase
IOD25_RS12045	COG2203	Gaf domain
IOD25_RS12045	COG3706	GGDEF domain
IOD25_RS12060	COG1126	abc transporter atp-binding protein
IOD25_RS12065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD25_RS12070	COG4215	(ABC) transporter
IOD25_RS12075	COG4160	amino acid transport
IOD25_RS12080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD25_RS12085	COG5002	protein histidine kinase activity
IOD25_RS12090	COG0745	RESPONSE REGULATOR receiver
IOD25_RS12105	COG1177	transmembrane transport
IOD25_RS12110	COG1176	ABC-type spermidine putrescine transport system, permease component I
IOD25_RS12115	COG3842	ATPase activity
IOD25_RS12120	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IOD25_RS12135	COG0778	Nitroreductase
IOD25_RS12160	COG3226	Transcriptional regulator
IOD25_RS12165	COG0738	Major facilitator superfamily
IOD25_RS12170	COG0561	phosphatase activity
IOD25_RS12175	COG2814	Major facilitator Superfamily
IOD25_RS12180	COG0671	phosphoesterase, PA-phosphatase related
IOD25_RS12185	COG1349	DNA-binding transcription factor activity
IOD25_RS12190	COG1686	Belongs to the peptidase S11 family
IOD25_RS12200	COG0625	glutathione transferase activity
IOD25_RS12205	COG2133	pyrroloquinoline quinone binding
IOD25_RS12215	COG2223	nitrite transmembrane transporter activity
IOD25_RS12235	COG0747	negative chemotaxis
IOD25_RS12250	COG0303	'Molybdopterin
IOD25_RS12255	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IOD25_RS12260	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IOD25_RS12265	COG1882	Formate acetyltransferase
IOD25_RS12270	COG0561	phosphatase activity
IOD25_RS12280	COG1609	Transcriptional regulator
IOD25_RS12295	COG0488	(ABC) transporter
IOD25_RS12300	COG2365	Tyrosine phosphatase family
IOD25_RS12305	COG1376	ErfK ybiS ycfS ynhG family protein
IOD25_RS12310	COG2188	Transcriptional regulator
IOD25_RS12315	COG2723	6-phospho-beta-galactosidase activity
IOD25_RS12320	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IOD25_RS12335	COG2194	sulfuric ester hydrolase activity
IOD25_RS12340	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IOD25_RS12355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD25_RS12360	COG0765	amino acid transport
IOD25_RS12365	COG1126	abc transporter atp-binding protein
IOD25_RS12370	COG0668	transmembrane transport
IOD25_RS12380	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IOD25_RS12390	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IOD25_RS12400	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IOD25_RS12405	COG1199	ATP-dependent helicase activity
IOD25_RS12410	COG0513	Belongs to the DEAD box helicase family
IOD25_RS12415	COG3958	Transketolase
IOD25_RS12420	COG3959	Transketolase, thiamine diphosphate binding domain
IOD25_RS12425	COG1028	Short-chain dehydrogenase reductase Sdr
IOD25_RS12430	COG2271	Major facilitator Superfamily
IOD25_RS12440	COG0583	DNA-binding transcription factor activity
IOD25_RS12445	COG1309	transcriptional regulator
IOD25_RS12450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOD25_RS12455	COG1131	(ABC) transporter
IOD25_RS12460	COG0842	Transport permease protein
IOD25_RS12465	COG0842	Transport permease protein
IOD25_RS12475	COG3568	Endonuclease Exonuclease Phosphatase
IOD25_RS12480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IOD25_RS12485	COG0392	lysyltransferase activity
IOD25_RS12495	COG0670	Belongs to the BI1 family
IOD25_RS12500	COG0314	molybdopterin synthase activity
IOD25_RS12505	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IOD25_RS12515	COG0521	Mo-molybdopterin cofactor biosynthetic process
IOD25_RS12535	COG0745	RESPONSE REGULATOR receiver
IOD25_RS12540	COG0642	Histidine kinase
IOD25_RS12565	COG2226	methyltransferase
IOD25_RS12580	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IOD25_RS12585	COG1881	PFAM PEBP family protein
IOD25_RS12625	COG4677	pectinesterase activity
IOD25_RS12640	COG0589	response to stress
IOD25_RS12645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOD25_RS12680	COG0789	Transcriptional regulator
IOD25_RS12685	COG2200	EAL domain
IOD25_RS12710	COG0561	phosphatase activity
IOD25_RS12720	COG4149	molybdate abc transporter
IOD25_RS12725	COG0725	ABC transporter, periplasmic molybdate-binding protein
IOD25_RS12735	COG3585	molybdate ion transport
IOD25_RS12735	COG2005	Transcriptional regulator
IOD25_RS12740	COG1119	ATPase activity
IOD25_RS12750	COG1085	galactose-1-phosphate uridylyltransferase
IOD25_RS12760	COG2017	converts alpha-aldose to the beta-anomer
IOD25_RS12770	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IOD25_RS12785	COG3201	nicotinamide mononucleotide transporter
IOD25_RS12790	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IOD25_RS12830	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
IOD25_RS12835	COG2885	chlorophyll binding
IOD25_RS12845	COG3064	Membrane
IOD25_RS12850	COG0848	biopolymer transport protein
IOD25_RS12855	COG0811	peptide transport
IOD25_RS12860	COG0824	Thioesterase
IOD25_RS12865	COG3790	cyd operon protein YbgE
IOD25_RS12870	COG4890	Cyd operon protein YbgT
IOD25_RS12875	COG1294	oxidase, subunit
IOD25_RS12880	COG1271	oxidase subunit
IOD25_RS12885	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IOD25_RS12895	COG0508	dehydrogenase complex catalyzes the overall conversion of
IOD25_RS12900	COG0567	Dehydrogenase, E1 component
IOD25_RS12905	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IOD25_RS12910	COG1053	succinate dehydrogenase
IOD25_RS12915	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IOD25_RS12920	COG2009	succinate dehydrogenase
IOD25_RS12955	COG1984	allophanate hydrolase subunit 2
IOD25_RS12960	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IOD25_RS12975	COG0415	Belongs to the DNA photolyase family
IOD25_RS13005	COG2205	protein histidine kinase activity
IOD25_RS13010	COG0745	RESPONSE REGULATOR receiver
IOD25_RS13020	COG0033	Phosphoglucomutase
IOD25_RS13030	COG0596	Alpha beta hydrolase
IOD25_RS13045	COG0735	belongs to the Fur family
IOD25_RS13085	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IOD25_RS13090	COG1940	carbohydrate kinase activity
IOD25_RS13090	COG1846	Transcriptional regulator
IOD25_RS13095	COG0647	UMP catabolic process
IOD25_RS13100	COG0367	asparagine synthase
IOD25_RS13140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOD25_RS13150	COG1702	phosphate starvation-inducible protein PhoH
IOD25_RS13175	COG0765	amino acid transport
IOD25_RS13180	COG0765	amino acid transport
IOD25_RS13185	COG1126	abc transporter atp-binding protein
IOD25_RS13200	COG2888	peptidyl-tyrosine sulfation
IOD25_RS13215	COG1466	dna polymerase III delta subunit
IOD25_RS13230	COG0799	negative regulation of ribosome biogenesis
IOD25_RS13240	COG0768	penicillin binding
IOD25_RS13245	COG0772	Belongs to the SEDS family
IOD25_RS13250	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IOD25_RS13255	COG1686	Belongs to the peptidase S11 family
IOD25_RS13270	COG0583	DNA-binding transcription factor activity
IOD25_RS13280	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IOD25_RS13285	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IOD25_RS13305	COG3069	C4-dicarboxylate transmembrane transporter activity
IOD25_RS13310	COG3719	Belongs to the RNase T2 family
IOD25_RS13315	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IOD25_RS13335	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IOD25_RS13340	COG0583	DNA-binding transcription factor activity
IOD25_RS13345	COG3969	phosphoadenosine phosphosulfate
IOD25_RS13350	COG1475	DNA binding
IOD25_RS13355	COG0436	Aminotransferase
IOD25_RS13385	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD25_RS13390	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD25_RS13400	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IOD25_RS13415	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IOD25_RS13425	COG0402	S-adenosylhomocysteine deaminase activity
IOD25_RS13435	COG0483	inositol monophosphate 1-phosphatase activity
IOD25_RS13440	COG2271	Major facilitator Superfamily
IOD25_RS13475	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD25_RS13480	COG1129	ABC transporter
IOD25_RS13485	COG0371	Dehydrogenase
IOD25_RS13490	COG1028	Short-chain dehydrogenase reductase Sdr
IOD25_RS13505	COG2879	small protein
IOD25_RS13510	COG1966	Carbon starvation protein
IOD25_RS13520	COG1028	Short-chain dehydrogenase reductase Sdr
IOD25_RS13525	COG1535	isochorismatase
IOD25_RS13525	COG3433	isochorismatase activity
IOD25_RS13530	COG1021	2,3-dihydroxybenzoate-AMP ligase
IOD25_RS13535	COG1169	isochorismate synthase
IOD25_RS13540	COG4592	Periplasmic binding protein
IOD25_RS13545	COG0477	Major facilitator Superfamily
IOD25_RS13550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOD25_RS13555	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOD25_RS13560	COG1120	ATPase activity
IOD25_RS13565	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
IOD25_RS13565	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IOD25_RS13570	COG3251	PFAM MbtH domain protein
IOD25_RS13575	COG2382	esterase
IOD25_RS13585	COG2977	Belongs to the P-Pant transferase superfamily
IOD25_RS13590	COG3958	Transketolase
IOD25_RS13595	COG3959	Transketolase, thiamine diphosphate binding domain
IOD25_RS13600	COG2390	Transcriptional regulator
IOD25_RS13605	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IOD25_RS13610	COG1879	ABC-type sugar transport system periplasmic component
IOD25_RS13620	COG1129	ABC transporter
IOD25_RS13625	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD25_RS13635	COG1028	Short-chain dehydrogenase reductase Sdr
IOD25_RS13645	COG0583	DNA-binding transcription factor activity
IOD25_RS13650	COG0668	transmembrane transport
IOD25_RS13660	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IOD25_RS13685	COG0747	negative chemotaxis
IOD25_RS13690	COG0601	transmembrane transport
IOD25_RS13695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOD25_RS13700	COG0444	Belongs to the ABC transporter superfamily
IOD25_RS13705	COG4608	Belongs to the ABC transporter superfamily
IOD25_RS13715	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IOD25_RS13720	COG4221	oxidoreductase activity
IOD25_RS13730	COG4215	(ABC) transporter
IOD25_RS13735	COG0765	amino acid transport
IOD25_RS13740	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IOD25_RS13755	COG0697	spore germination
IOD25_RS13770	COG4608	Belongs to the ABC transporter superfamily
IOD25_RS13775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOD25_RS13840	COG2315	Protein conserved in bacteria
IOD25_RS13845	COG0778	Nitroreductase
IOD25_RS13855	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IOD25_RS13865	COG3716	PTS system mannose fructose sorbose family IID component
IOD25_RS13870	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IOD25_RS13875	COG2222	sugar isomerase
IOD25_RS13880	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IOD25_RS13880	COG3933	PFAM sigma-54 factor interaction domain-containing protein
IOD25_RS13905	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IOD25_RS13940	COG0477	Major facilitator Superfamily
IOD25_RS13945	COG0668	transmembrane transport
IOD25_RS13950	COG1609	Transcriptional regulator
IOD25_RS13970	COG2211	Major facilitator Superfamily
IOD25_RS13975	COG1113	amino acid transport
IOD25_RS13990	COG1012	belongs to the aldehyde dehydrogenase family
IOD25_RS13995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IOD25_RS14005	COG0531	amino acid
IOD25_RS14050	COG0667	Aldo Keto reductase
IOD25_RS14055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD25_RS14060	COG1473	amidohydrolase
IOD25_RS14090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOD25_RS14095	COG1120	ATPase activity
IOD25_RS14100	COG1566	PFAM secretion protein HlyD family protein
IOD25_RS14145	COG4211	Belongs to the binding-protein-dependent transport system permease family
IOD25_RS14150	COG1129	ABC transporter
IOD25_RS14165	COG0673	inositol 2-dehydrogenase activity
IOD25_RS14195	COG3104	oligopeptide transport
IOD25_RS14200	COG1982	Orn Lys Arg decarboxylase major
IOD25_RS14205	COG0531	amino acid
IOD25_RS14220	COG1560	Kdo2-lipid A biosynthetic process
IOD25_RS14235	COG3188	usher protein
IOD25_RS14240	COG3121	Chaperone
IOD25_RS14245	COG3539	Fimbrial protein
IOD25_RS14440	COG3567	Phage-associated protein, HI1409 family
IOD25_RS14445	COG1783	phage Terminase large subunit
IOD25_RS14470	COG3772	lysozyme
IOD25_RS14485	COG0484	heat shock protein binding
IOD25_RS14500	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IOD25_RS14590	COG0455	bacterial-type flagellum organization
IOD25_RS14665	COG2501	S4 domain
IOD25_RS14675	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IOD25_RS14690	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IOD25_RS14695	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IOD25_RS14715	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IOD25_RS14720	COG4181	ATPase activity
IOD25_RS14725	COG2755	lipolytic protein G-D-S-L family
IOD25_RS14730	COG0300	oxidoreductase activity
IOD25_RS14735	COG3118	belongs to the thioredoxin family
IOD25_RS14740	COG0390	transport system, permease component
IOD25_RS14745	COG4619	ABC transporter
IOD25_RS14750	COG0330	HflC and HflK could
IOD25_RS14755	COG1585	Membrane protein implicated in regulation of membrane protease activity
IOD25_RS14770	COG3735	TraB family
IOD25_RS14775	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IOD25_RS14785	COG2223	nitrite transmembrane transporter activity
IOD25_RS14790	COG4651	solute:proton antiporter activity
IOD25_RS14790	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IOD25_RS14795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOD25_RS14835	COG2832	Protein of unknown function (DUF454)
IOD25_RS14840	COG3923	Primosomal replication protein n
IOD25_RS14850	COG5464	transposase or invertase
IOD25_RS14855	COG1196	nuclear chromosome segregation
IOD25_RS14855	COG3264	Mechanosensitive ion channel
IOD25_RS14860	COG1309	transcriptional regulator
IOD25_RS14865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOD25_RS14870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IOD25_RS14885	COG0110	maltose O-acetyltransferase activity
IOD25_RS14935	COG1874	Beta-galactosidase
IOD25_RS14940	COG3867	Arabinogalactan endo-beta-1,4-galactanase
IOD25_RS14945	COG3833	ABC-type maltose transport systems, permease component
IOD25_RS14950	COG1175	transmembrane transport
IOD25_RS14955	COG2182	Extracellular solute-binding protein
IOD25_RS14965	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IOD25_RS14980	COG2364	Membrane
IOD25_RS15010	COG3695	enzyme binding
IOD25_RS15015	COG3126	Type III secretion system lipoprotein chaperone (YscW)
IOD25_RS15020	COG1946	Acyl-CoA thioesterase
IOD25_RS15025	COG0004	ammonium transporteR
IOD25_RS15030	COG0347	Belongs to the P(II) protein family
IOD25_RS15035	COG1132	(ABC) transporter
IOD25_RS15040	COG1132	(ABC) transporter
IOD25_RS15045	COG1522	sequence-specific DNA binding
IOD25_RS15060	COG4533	DNA binding
IOD25_RS15070	COG0824	Thioesterase
IOD25_RS15075	COG1555	photosystem II stabilization
IOD25_RS15080	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IOD25_RS15085	COG0776	regulation of translation
IOD25_RS15090	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IOD25_RS15110	COG0271	Belongs to the BolA IbaG family
IOD25_RS15115	COG3056	Lipoprotein
IOD25_RS15120	COG2223	nitrite transmembrane transporter activity
IOD25_RS15125	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IOD25_RS15130	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IOD25_RS15135	COG1845	cytochrome c oxidase, subunit III
IOD25_RS15140	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IOD25_RS15155	COG1414	Transcriptional regulator
IOD25_RS15160	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IOD25_RS15165	COG1053	succinate dehydrogenase
IOD25_RS15175	COG1053	succinate dehydrogenase
IOD25_RS15190	COG0673	inositol 2-dehydrogenase activity
IOD25_RS15195	COG2814	Major facilitator Superfamily
IOD25_RS15205	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IOD25_RS15210	COG0693	protein deglycase activity
IOD25_RS15230	COG0142	geranyltranstransferase activity
IOD25_RS15245	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IOD25_RS15265	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IOD25_RS15265	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IOD25_RS15275	COG4238	major outer membrane lipoprotein
IOD25_RS15295	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IOD25_RS15300	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IOD25_RS15305	COG1862	Preprotein translocase
IOD25_RS15330	COG0450	alkyl hydroperoxide reductase
IOD25_RS15335	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD25_RS15355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOD25_RS15365	COG1228	amidohydrolase
IOD25_RS15375	COG1335	isochorismatase
IOD25_RS15380	COG0583	DNA-binding transcription factor activity
IOD25_RS15385	COG0366	Alpha amylase catalytic
IOD25_RS15410	COG0420	3'-5' exonuclease activity
IOD25_RS15415	COG0419	ATPase involved in DNA repair
IOD25_RS15420	COG1940	carbohydrate kinase activity
IOD25_RS15435	COG4126	flavin adenine dinucleotide binding
IOD25_RS15445	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IOD25_RS15450	COG3416	Protein conserved in bacteria
IOD25_RS15460	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IOD25_RS15470	COG1785	Belongs to the alkaline phosphatase family
IOD25_RS15510	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
IOD25_RS15515	COG1335	isochorismatase
IOD25_RS15520	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IOD25_RS15525	COG0113	porphobilinogen synthase activity
IOD25_RS15530	COG1943	Transposase
IOD25_RS15545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IOD25_RS15550	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IOD25_RS15555	COG4521	taurine ABC transporter
IOD25_RS15560	COG2040	homocysteine
IOD25_RS15565	COG0833	amino acid
IOD25_RS15580	COG4303	Ethanolamine ammonia lyase large subunit
IOD25_RS15585	COG4302	ethanolamine ammonia-lyase activity
IOD25_RS15625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD25_RS15630	COG1126	abc transporter atp-binding protein
IOD25_RS15635	COG4597	amino acid ABC transporter
IOD25_RS15640	COG0765	amino acid transport
IOD25_RS15655	COG3188	usher protein
IOD25_RS15680	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
IOD25_RS15690	COG3639	organic phosphonate transmembrane transporter activity
IOD25_RS15715	COG0791	NLP P60 protein
IOD25_RS15745	COG0765	amino acid transport
IOD25_RS15755	COG4221	oxidoreductase activity
IOD25_RS15770	COG0436	Aminotransferase
IOD25_RS15775	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IOD25_RS15780	COG1984	allophanate hydrolase subunit 2
IOD25_RS15795	COG0697	spore germination
IOD25_RS15800	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IOD25_RS15805	COG0439	Biotin carboxylase
IOD25_RS15810	COG0511	ligase activity, forming carbon-carbon bonds
IOD25_RS15820	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IOD25_RS15825	COG0022	dehydrogenase e1 component
IOD25_RS15830	COG0508	dehydrogenase complex catalyzes the overall conversion of
IOD25_RS15835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IOD25_RS15845	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
IOD25_RS15860	COG0579	oxidoreductase
IOD25_RS15865	COG1012	belongs to the aldehyde dehydrogenase family
IOD25_RS15870	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IOD25_RS15875	COG1113	amino acid transport
IOD25_RS15880	COG1802	Transcriptional regulator
IOD25_RS15900	COG2195	Cleaves the N-terminal amino acid of tripeptides
IOD25_RS15905	COG0454	-acetyltransferase
IOD25_RS15920	COG2991	Protein conserved in bacteria
IOD25_RS15935	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IOD25_RS15940	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IOD25_RS15955	COG3034	peptidoglycan biosynthetic process
IOD25_RS15960	COG0121	glutamine amidotransferase
IOD25_RS15970	COG1960	acyl-CoA dehydrogenase activity
IOD25_RS15975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IOD25_RS15985	COG0583	DNA-binding transcription factor activity
IOD25_RS15995	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IOD25_RS16005	COG2226	methyltransferase
IOD25_RS16015	COG1388	LysM domain
IOD25_RS16015	COG0741	lytic transglycosylase activity
IOD25_RS16020	COG2226	methyltransferase
IOD25_RS16030	COG2814	Major facilitator Superfamily
IOD25_RS16035	COG0583	DNA-binding transcription factor activity
IOD25_RS16040	COG0656	L-ascorbic acid biosynthetic process
IOD25_RS16075	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IOD25_RS16085	COG2011	ABC-type metal ion transport system permease component
IOD25_RS16090	COG1464	Belongs to the NlpA lipoprotein family
IOD25_RS16100	COG1720	tRNA m6t6A37 methyltransferase activity
IOD25_RS16110	COG0791	NLP P60 protein
IOD25_RS16115	COG3015	lipoprotein NlpE involved in copper resistance
IOD25_RS16120	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IOD25_RS16135	COG4568	rho-dependent transcription termination
IOD25_RS16145	COG0346	lactoylglutathione lyase activity
IOD25_RS16150	COG1982	Orn Lys Arg decarboxylase major
IOD25_RS16190	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
IOD25_RS16200	COG0750	zinc metalloprotease
IOD25_RS16205	COG0575	Belongs to the CDS family
IOD25_RS16215	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IOD25_RS16240	COG0024	Methionine aminopeptidase
IOD25_RS16245	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IOD25_RS16260	COG3835	regulator
IOD25_RS16265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IOD25_RS16285	COG2860	membrane
IOD25_RS16305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOD25_RS16310	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IOD25_RS16315	COG1120	ATPase activity
IOD25_RS16325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IOD25_RS16415	COG1643	Atp-dependent helicase
IOD25_RS16420	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
IOD25_RS16440	COG0617	tRNA 3'-terminal CCA addition
IOD25_RS16445	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IOD25_RS16465	COG0726	polysaccharide deacetylase
IOD25_RS16470	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD25_RS16475	COG0842	Transport permease protein
IOD25_RS16480	COG1131	(ABC) transporter
IOD25_RS16485	COG0288	reversible hydration of carbon dioxide
IOD25_RS16500	COG4993	Dehydrogenase
IOD25_RS16505	COG2132	Multicopper oxidase
IOD25_RS16550	COG3064	Membrane
IOD25_RS16565	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IOD25_RS16570	COG0508	dehydrogenase complex catalyzes the overall conversion of
IOD25_RS16575	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IOD25_RS16580	COG2186	Transcriptional regulator
IOD25_RS16585	COG1113	amino acid transport
IOD25_RS16590	COG2211	Major facilitator Superfamily
IOD25_RS16595	COG3940	Belongs to the glycosyl hydrolase 43 family
IOD25_RS16600	COG3725	Membrane protein required for beta-lactamase induction
IOD25_RS16605	COG3023	N-Acetylmuramoyl-L-alanine amidase
IOD25_RS16615	COG4969	Belongs to the N-Me-Phe pilin family
IOD25_RS16620	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IOD25_RS16625	COG1459	type II secretion system
IOD25_RS16650	COG0494	nUDIX hydrolase
IOD25_RS16670	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IOD25_RS16675	COG0849	cell division
IOD25_RS16700	COG0772	Belongs to the SEDS family
IOD25_RS16715	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IOD25_RS16720	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IOD25_RS16725	COG0768	penicillin binding
IOD25_RS16745	COG1609	Transcriptional regulator
IOD25_RS16755	COG0028	Belongs to the TPP enzyme family
IOD25_RS16800	COG0738	Major facilitator superfamily
IOD25_RS16815	COG2271	Major facilitator Superfamily
IOD25_RS16820	COG2814	Major facilitator Superfamily
IOD25_RS16840	COG1178	ABC-type Fe3 transport system permease component
IOD25_RS16850	COG0586	Pfam SNARE associated Golgi protein
IOD25_RS16870	COG0235	Class ii aldolase
IOD25_RS16875	COG0417	DNA replication proofreading
IOD25_RS16885	COG0564	pseudouridine synthase activity
IOD25_RS16895	COG3493	citrate carrier protein
IOD25_RS16910	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IOD25_RS16915	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IOD25_RS16925	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IOD25_RS16970	COG0505	Belongs to the CarA family
IOD25_RS17060	COG1047	Peptidyl-prolyl cis-trans
IOD25_RS17075	COG0196	riboflavin kinase activity
IOD25_RS17110	COG4735	regulation of single-species biofilm formation
IOD25_RS17115	COG1584	GPR1 FUN34 yaaH family protein
IOD25_RS17120	COG0477	Major facilitator Superfamily
IOD25_RS17125	COG0521	Mo-molybdopterin cofactor biosynthetic process
IOD25_RS17130	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IOD25_RS17135	COG1115	amino acid carrier protein
IOD25_RS17150	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IOD25_RS17160	COG0527	aspartate kinase activity
IOD25_RS17160	COG0460	homoserine dehydrogenase
IOD25_RS17170	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
IOD25_RS17180	COG0745	RESPONSE REGULATOR receiver
IOD25_RS17185	COG4452	Inner membrane protein CreD
IOD25_RS17195	COG0745	RESPONSE REGULATOR receiver
IOD25_RS17200	COG3045	CreA protein
IOD25_RS17205	COG3708	Transcriptional regulator
IOD25_RS17205	COG2207	Transcriptional regulator
IOD25_RS17225	COG0741	lytic transglycosylase activity
IOD25_RS17230	COG0488	(ABC) transporter
IOD25_RS17240	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IOD25_RS17245	COG0560	Phosphoserine phosphatase
IOD25_RS17250	COG3726	membrane protein affecting hemolysin expression
IOD25_RS17280	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IOD25_RS17285	COG0084	hydrolase, TatD family'
IOD25_RS17290	COG4667	esterase of the alpha-beta hydrolase superfamily
IOD25_RS17300	COG2823	Periplasmic or secreted lipoprotein
IOD25_RS17310	COG1011	Hydrolase
IOD25_RS17315	COG0456	acetyltransferase
IOD25_RS17320	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
IOD25_RS17355	COG3706	GGDEF domain
IOD25_RS17360	COG4114	ferric iron reductase
IOD25_RS17365	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IOD25_RS17365	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IOD25_RS17370	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IOD25_RS17375	COG2197	response regulator
IOD25_RS17380	COG2197	response regulator
IOD25_RS17395	COG2966	Psort location CytoplasmicMembrane, score
IOD25_RS17410	COG1484	DNA-dependent DNA replication
IOD25_RS17425	COG5464	transposase or invertase
IOD25_RS17435	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IOD25_RS17440	COG3716	PTS system mannose fructose sorbose family IID component
IOD25_RS17445	COG3715	PTS system
IOD25_RS17460	COG3933	PFAM sigma-54 factor interaction domain-containing protein
IOD25_RS17460	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IOD25_RS17465	COG0456	acetyltransferase
IOD25_RS17465	COG1214	PFAM Peptidase M22, glycoprotease
IOD25_RS17475	COG1737	Transcriptional regulator
IOD25_RS17480	COG0800	Aldolase
IOD25_RS17485	COG3734	2-keto-3-deoxy-galactonokinase
IOD25_RS17500	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IOD25_RS17530	COG1846	Transcriptional regulator
IOD25_RS17540	COG0179	Fumarylacetoacetate (FAA) hydrolase
IOD25_RS17550	COG1012	belongs to the aldehyde dehydrogenase family
IOD25_RS17555	COG3384	dioxygenase
IOD25_RS17565	COG3971	2-oxopent-4-enoate hydratase activity
IOD25_RS17585	COG2368	4-hydroxyphenylacetate
IOD25_RS17590	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IOD25_RS17595	COG1966	Carbon starvation protein
IOD25_RS17600	COG2879	small protein
IOD25_RS17605	COG0523	cobalamin synthesis protein
IOD25_RS17615	COG1012	belongs to the aldehyde dehydrogenase family
IOD25_RS17620	COG5464	transposase or invertase
IOD25_RS17625	COG2207	Transcriptional regulator
IOD25_RS17625	COG1917	Cupin 2, conserved barrel domain protein
IOD25_RS17635	COG2733	membrane
IOD25_RS17650	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
IOD25_RS17655	COG1924	4 iron, 4 sulfur cluster binding
IOD25_RS17670	COG1566	PFAM secretion protein HlyD family protein
IOD25_RS17680	COG5457	Domain of unknown function (DUF1127)
IOD25_RS17685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOD25_RS17695	COG0583	DNA-binding transcription factor activity
IOD25_RS17700	COG2249	NAD(P)H dehydrogenase (quinone) activity
IOD25_RS17710	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD25_RS17715	COG1129	ABC transporter
IOD25_RS17720	COG1879	ABC-type sugar transport system periplasmic component
IOD25_RS17730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOD25_RS17735	COG0842	Transport permease protein
IOD25_RS17735	COG1129	ABC transporter
IOD25_RS17740	COG0842	Transport permease protein
IOD25_RS17770	COG2850	peptidyl-arginine hydroxylation
IOD25_RS17785	COG5002	protein histidine kinase activity
IOD25_RS17790	COG0745	RESPONSE REGULATOR receiver
IOD25_RS17795	COG1538	Outer membrane efflux protein
IOD25_RS17800	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOD25_RS17805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOD25_RS17810	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IOD25_RS17820	COG3040	lipid binding
IOD25_RS17825	COG0789	Transcriptional regulator
IOD25_RS17830	COG3631	Ketosteroid isomerase-related protein
IOD25_RS17835	COG0300	oxidoreductase activity
IOD25_RS17850	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IOD25_RS17870	COG3272	Protein of unknown function (DUF1722)
IOD25_RS17875	COG4580	involved in the transport of maltose and maltodextrins
IOD25_RS17975	COG0582	viral genome integration into host DNA
IOD25_RS17985	COG0288	reversible hydration of carbon dioxide
IOD25_RS17990	COG0659	secondary active sulfate transmembrane transporter activity
IOD25_RS17995	COG1064	alcohol dehydrogenase
IOD25_RS18000	COG1175	transmembrane transport
IOD25_RS18005	COG0395	ABC-type sugar transport system, permease component
IOD25_RS18010	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IOD25_RS18015	COG3842	ATPase activity
IOD25_RS18020	COG1653	transport
IOD25_RS18030	COG1082	Xylose isomerase domain protein TIM barrel
IOD25_RS18040	COG3962	Belongs to the TPP enzyme family
IOD25_RS18045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOD25_RS18050	COG0837	glucose binding
IOD25_RS18050	COG1737	Transcriptional regulator
IOD25_RS18055	COG3718	enzyme involved in inositol metabolism
IOD25_RS18070	COG0433	COG0433 Predicted ATPase
IOD25_RS18075	COG0795	lipopolysaccharide-transporting ATPase activity
IOD25_RS18080	COG0795	lipopolysaccharide-transporting ATPase activity
IOD25_RS18090	COG2927	DNA polymerase III (CHI subunit)
IOD25_RS18095	COG0525	valine-tRNA ligase activity
IOD25_RS18120	COG2731	YhcH YjgK YiaL family protein
IOD25_RS18155	COG1263	PTS System
IOD25_RS18155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IOD25_RS18160	COG0366	Alpha amylase catalytic
IOD25_RS18165	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IOD25_RS18170	COG1486	melibiose metabolic process
IOD25_RS18195	COG0602	queuosine metabolic process
IOD25_RS18200	COG2026	Addiction module toxin, RelE StbE family
IOD25_RS18205	COG3077	Addiction module antitoxin, RelB DinJ family
IOD25_RS18210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD25_RS18210	COG3711	transcriptional antiterminator
IOD25_RS18215	COG2706	6-phosphogluconolactonase activity
IOD25_RS18230	COG3964	amidohydrolase
IOD25_RS18265	COG0312	modulator of DNA gyrase
IOD25_RS18290	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IOD25_RS18300	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD25_RS18305	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD25_RS18310	COG1129	ABC transporter
IOD25_RS18315	COG1879	ABC-type sugar transport system periplasmic component
IOD25_RS18335	COG2105	PFAM AIG2 family protein
IOD25_RS18340	COG2911	Protein conserved in bacteria
IOD25_RS18345	COG0729	surface antigen
IOD25_RS18355	COG1253	flavin adenine dinucleotide binding
IOD25_RS18370	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
IOD25_RS18385	COG1733	regulation of RNA biosynthetic process
IOD25_RS18390	COG0702	epimerase
IOD25_RS18400	COG0697	spore germination
IOD25_RS18410	COG1113	amino acid transport
IOD25_RS18415	COG0545	Peptidyl-prolyl cis-trans isomerase
IOD25_RS18420	COG3061	Opacity-associated protein A
IOD25_RS18430	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IOD25_RS18435	COG2965	DNA replication, synthesis of RNA primer
IOD25_RS18495	COG1073	alpha beta
IOD25_RS18500	COG3650	response to hydrogen peroxide
IOD25_RS18510	COG1960	acyl-CoA dehydrogenase activity
IOD25_RS18515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IOD25_RS18520	COG0557	exoribonuclease II activity
IOD25_RS18535	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
IOD25_RS18545	COG0330	HflC and HflK could
IOD25_RS18550	COG0330	HflC and HflK could
IOD25_RS18555	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IOD25_RS18575	COG0860	N-Acetylmuramoyl-L-alanine amidase
IOD25_RS18580	COG0802	atpase or kinase
IOD25_RS18585	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IOD25_RS18585	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IOD25_RS18590	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IOD25_RS18610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD25_RS18630	COG1511	domain protein
IOD25_RS18630	COG3264	Mechanosensitive ion channel
IOD25_RS18645	COG1053	succinate dehydrogenase
IOD25_RS18650	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IOD25_RS18670	COG2076	Multidrug Resistance protein
IOD25_RS18675	COG5510	response to toxic substance
IOD25_RS18690	COG1509	lysine 2,3-aminomutase activity
IOD25_RS18695	COG0745	RESPONSE REGULATOR receiver
IOD25_RS18750	COG3539	Fimbrial protein
IOD25_RS18770	COG0531	amino acid
IOD25_RS18775	COG3030	protein affecting phage T7 exclusion by the F plasmid
IOD25_RS18780	COG1027	Aspartate ammonia-lyase
IOD25_RS18785	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IOD25_RS18800	COG1309	transcriptional regulator
IOD25_RS18830	COG0457	Tetratricopeptide repeat
IOD25_RS18835	COG0726	polysaccharide deacetylase
IOD25_RS18835	COG1649	PFAM Uncharacterised BCR, COG1649
IOD25_RS18840	COG1215	transferase activity, transferring glycosyl groups
IOD25_RS18855	COG0861	Integral membrane protein TerC family
IOD25_RS18900	COG1486	melibiose metabolic process
IOD25_RS18905	COG2169	Transcriptional regulator
IOD25_RS18915	COG2824	Alkylphosphonate utilization operon protein PhnA
IOD25_RS18920	COG2764	glyoxalase bleomycin resistance protein dioxygenase
IOD25_RS18925	COG2188	Transcriptional regulator
IOD25_RS18930	COG3624	Phosphonate C-P lyase system protein PhnG
IOD25_RS18935	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
IOD25_RS18940	COG3626	phosphonate metabolism
IOD25_RS18945	COG3627	carbon phosphorus lyase activity
IOD25_RS18950	COG4107	phosphonate C-P lyase system protein PhnK
IOD25_RS18955	COG4778	phosphonate C-P lyase system protein PhnL
IOD25_RS18960	COG3454	Phosphonate metabolism
IOD25_RS18970	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IOD25_RS18980	COG0784	Response regulator, receiver
IOD25_RS18980	COG4191	Histidine kinase
IOD25_RS18985	COG1129	ABC transporter
IOD25_RS18990	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD25_RS19025	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
IOD25_RS19030	COG1301	dicarboxylic acid transport
IOD25_RS19040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IOD25_RS19045	COG3162	membrane
IOD25_RS19075	COG3539	Fimbrial protein
IOD25_RS19080	COG1346	cytolysis
IOD25_RS19085	COG1380	Effector of murein hydrolase LrgA
IOD25_RS19090	COG0583	DNA-binding transcription factor activity
IOD25_RS19095	COG0025	NhaP-type Na H and K H
IOD25_RS19100	COG2252	PERMEase
IOD25_RS19105	COG0625	glutathione transferase activity
IOD25_RS19110	COG0789	Transcriptional regulator
IOD25_RS19120	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IOD25_RS19150	COG1234	tRNA 3'-trailer cleavage
IOD25_RS19155	COG1609	Transcriptional regulator
IOD25_RS19160	COG0483	inositol monophosphate 1-phosphatase activity
IOD25_RS19170	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IOD25_RS19190	COG4771	TonB-dependent receptor
IOD25_RS19195	COG0741	lytic transglycosylase activity
IOD25_RS19210	COG2315	Protein conserved in bacteria
IOD25_RS19215	COG0432	Pfam Uncharacterised protein family UPF0047
IOD25_RS19230	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IOD25_RS19235	COG0305	Participates in initiation and elongation during chromosome replication
IOD25_RS19250	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IOD25_RS19260	COG0735	belongs to the Fur family
IOD25_RS19265	COG3237	CsbD-like
IOD25_RS19275	COG0534	Mate efflux family protein
IOD25_RS19285	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IOD25_RS19360	COG0251	oxidation-reduction process
IOD25_RS19370	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IOD25_RS19380	COG0527	aspartate kinase activity
IOD25_RS19430	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IOD25_RS19440	COG0456	acetyltransferase
IOD25_RS19470	COG0151	Belongs to the GarS family
IOD25_RS19480	COG4191	Histidine kinase
IOD25_RS19485	COG3678	ATP-independent chaperone mediated protein folding
IOD25_RS19520	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
IOD25_RS19535	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IOD25_RS19540	COG2104	thiamine diphosphate biosynthetic process
IOD25_RS19555	COG3706	GGDEF domain
IOD25_RS19565	COG1447	Phosphotransferase system cellobiose-specific component IIA
IOD25_RS19570	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IOD25_RS19605	COG0250	Participates in transcription elongation, termination and antitermination
IOD25_RS19650	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IOD25_RS19680	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
IOD25_RS19690	COG1739	Uncharacterized protein family UPF0029
IOD25_RS19730	COG0805	protein transport
IOD25_RS19750	COG3165	ubiquinone biosynthetic process from chorismate
IOD25_RS19780	COG0583	DNA-binding transcription factor activity
IOD25_RS19785	COG0697	spore germination
IOD25_RS19790	COG0561	phosphatase activity
IOD25_RS19795	COG2267	carboxylic ester hydrolase activity
IOD25_RS19800	COG1280	lysine exporter protein (LysE YggA)
IOD25_RS19810	COG1280	lysine exporter protein (LysE YggA)
IOD25_RS19840	COG0210	DNA helicase
IOD25_RS19845	COG1011	Hydrolase
IOD25_RS19875	COG3072	Adenylate cyclase
IOD25_RS19890	COG2959	enzyme of heme biosynthesis
IOD25_RS19895	COG3071	HemY protein
IOD25_RS19940	COG2244	polysaccharide biosynthetic process
IOD25_RS19945	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IOD25_RS19950	COG0456	acetyltransferase
IOD25_RS19955	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IOD25_RS19960	COG1088	dTDP-glucose 4,6-dehydratase activity
IOD25_RS19965	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IOD25_RS19970	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IOD25_RS19980	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IOD25_RS19985	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IOD25_RS19990	COG3118	belongs to the thioredoxin family
IOD25_RS20015	COG1811	Na channel or pump
IOD25_RS20025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IOD25_RS20030	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IOD25_RS20040	COG0583	DNA-binding transcription factor activity
IOD25_RS20045	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IOD25_RS20060	COG3978	acetolactate synthase activity
IOD25_RS20080	COG3085	chromosome segregation
IOD25_RS20155	COG0583	DNA-binding transcription factor activity
IOD25_RS20170	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IOD25_RS20185	COG3443	Belongs to the bacterial solute-binding protein 9 family
IOD25_RS20190	COG2207	Transcriptional regulator
IOD25_RS20200	COG0371	Dehydrogenase
IOD25_RS20205	COG0697	spore germination
IOD25_RS20215	COG0583	DNA-binding transcription factor activity
IOD25_RS20225	COG0737	Belongs to the 5'-nucleotidase family
IOD25_RS20235	COG0527	aspartate kinase activity
IOD25_RS20235	COG0460	homoserine dehydrogenase
IOD25_RS20240	COG0626	cystathionine gamma-synthase activity
IOD25_RS20255	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IOD25_RS20260	COG1609	Transcriptional regulator
IOD25_RS20265	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IOD25_RS20280	COG1575	Belongs to the MenA family. Type 1 subfamily
IOD25_RS20300	COG3678	ATP-independent chaperone mediated protein folding
IOD25_RS20305	COG0745	RESPONSE REGULATOR receiver
IOD25_RS20310	COG2205	protein histidine kinase activity
IOD25_RS20315	COG2258	MOSC domain
IOD25_RS20320	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IOD25_RS20360	COG1129	ABC transporter
IOD25_RS20365	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD25_RS20375	COG1454	alcohol dehydrogenase
IOD25_RS20385	COG2211	Major facilitator Superfamily
IOD25_RS20455	COG0205	6-phosphofructokinase activity
IOD25_RS20475	COG0437	4 iron, 4 sulfur cluster binding
IOD25_RS20480	COG2864	formate dehydrogenase
IOD25_RS20495	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IOD25_RS20505	COG0456	acetyltransferase
IOD25_RS20520	COG1011	Hydrolase
IOD25_RS20535	COG3852	Histidine kinase
IOD25_RS20550	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IOD25_RS20570	COG0204	Acyl-transferase
IOD25_RS20580	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IOD25_RS20585	COG3084	Protein conserved in bacteria
IOD25_RS20595	COG1763	Mo-molybdopterin cofactor biosynthetic process
IOD25_RS20620	COG2186	Transcriptional regulator
IOD25_RS20625	COG0477	Major facilitator Superfamily
IOD25_RS20630	COG1609	Transcriptional regulator
IOD25_RS20635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOD25_RS20645	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD25_RS20650	COG1129	ABC transporter
IOD25_RS20680	COG1522	sequence-specific DNA binding
IOD25_RS20685	COG0716	FMN binding
IOD25_RS20750	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IOD25_RS20755	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IOD25_RS20760	COG0573	inorganic phosphate transmembrane transporter activity
IOD25_RS20765	COG0581	inorganic phosphate transmembrane transporter activity
IOD25_RS20770	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IOD25_RS20775	COG0704	Plays a role in the regulation of phosphate uptake
IOD25_RS20785	COG2382	esterase
IOD25_RS20790	COG0363	glucosamine-6-phosphate deaminase activity
IOD25_RS20795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IOD25_RS20800	COG2252	PERMEase
IOD25_RS20805	COG0431	NADPH-dependent FMN reductase
IOD25_RS20810	COG2091	lysine biosynthetic process via aminoadipic acid
IOD25_RS20840	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IOD25_RS20870	COG0187	DNA topoisomerase II activity
IOD25_RS20875	COG0561	phosphatase activity
IOD25_RS20890	COG2186	Transcriptional regulator
IOD25_RS20895	COG3734	2-keto-3-deoxy-galactonokinase
IOD25_RS20900	COG0800	Aldolase
IOD25_RS20910	COG2271	Major facilitator Superfamily
IOD25_RS20915	COG0823	Involved in the tonB-independent uptake of proteins
IOD25_RS20920	COG5645	(Lipo)protein
IOD25_RS20945	COG2188	Transcriptional regulator
IOD25_RS20960	COG2149	membrane
IOD25_RS20980	COG2610	gluconate transmembrane transporter activity
IOD25_RS20990	COG0583	DNA-binding transcription factor activity
IOD25_RS20995	COG2814	Major facilitator Superfamily
IOD25_RS21025	COG0028	Belongs to the TPP enzyme family
IOD25_RS21030	COG0440	acetolactate synthase activity
IOD25_RS21035	COG2197	response regulator
IOD25_RS21045	COG2271	Major facilitator Superfamily
IOD25_RS21085	COG2188	Transcriptional regulator
IOD25_RS21095	COG3842	ATPase activity
IOD25_RS21110	COG4580	involved in the transport of maltose and maltodextrins
IOD25_RS21115	COG1447	Phosphotransferase system cellobiose-specific component IIA
IOD25_RS21120	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IOD25_RS21120	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IOD25_RS21130	COG1609	Transcriptional regulator
IOD25_RS21140	COG3384	dioxygenase
IOD25_RS21145	COG0583	DNA-binding transcription factor activity
IOD25_RS21150	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IOD25_RS21155	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IOD25_RS21160	COG2828	Protein conserved in bacteria
IOD25_RS21175	COG0697	spore germination
IOD25_RS21180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IOD25_RS21180	COG1263	PTS System
IOD25_RS21190	COG2814	Major facilitator Superfamily
IOD25_RS21200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IOD25_RS21235	COG0583	DNA-binding transcription factor activity
IOD25_RS21260	COG1464	Belongs to the NlpA lipoprotein family
IOD25_RS21275	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IOD25_RS21285	COG1064	alcohol dehydrogenase
IOD25_RS21315	COG2211	Major facilitator Superfamily
IOD25_RS21320	COG1501	Belongs to the glycosyl hydrolase 31 family
IOD25_RS21330	COG1486	melibiose metabolic process
IOD25_RS21335	COG1263	PTS System
IOD25_RS21335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IOD25_RS21340	COG2982	Protein involved in outer membrane biogenesis
IOD25_RS21345	COG2233	PERMEase
IOD25_RS21350	COG0786	glutamate:sodium symporter activity
IOD25_RS21370	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IOD25_RS21395	COG3152	Membrane
IOD25_RS21405	COG1494	fructose-1,6-bisphosphatase
IOD25_RS21410	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IOD25_RS21415	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IOD25_RS21420	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IOD25_RS21440	COG2860	membrane
IOD25_RS21450	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IOD25_RS21450	COG2169	Transcriptional regulator
IOD25_RS21455	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IOD25_RS21520	COG3561	AntA/AntB antirepressor
IOD25_RS21545	COG1561	YicC-like family, N-terminal region
IOD25_RS21600	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IOD25_RS21635	COG1519	Transferase
IOD25_RS21640	COG1216	Glycosyl transferase, family 2
IOD25_RS21645	COG0438	transferase activity, transferring glycosyl groups
IOD25_RS21655	COG0859	PFAM glycosyl transferase family 9
IOD25_RS21665	COG1442	glycosyl transferase family 8
IOD25_RS21665	COG1216	Glycosyl transferase, family 2
IOD25_RS21670	COG3307	-O-antigen
IOD25_RS21675	COG0438	transferase activity, transferring glycosyl groups
IOD25_RS21680	COG0859	PFAM glycosyl transferase family 9
IOD25_RS21695	COG0156	8-amino-7-oxononanoate synthase activity
IOD25_RS21705	COG0463	Glycosyl transferase, family 2
IOD25_RS21710	COG2861	carbohydrate metabolic process
IOD25_RS21715	COG4942	peptidase
IOD25_RS21725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IOD25_RS21730	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IOD25_RS21750	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IOD25_RS21760	COG2186	Transcriptional regulator
IOD25_RS21780	COG3722	fumarate hydratase activity
IOD25_RS21800	COG1566	PFAM secretion protein HlyD family protein
IOD25_RS21805	COG0625	glutathione transferase activity
IOD25_RS21815	COG3276	selenocysteine insertion sequence binding
IOD25_RS21825	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IOD25_RS21830	COG3977	Valine--pyruvate aminotransferase
IOD25_RS21835	COG0366	Alpha amylase catalytic
IOD25_RS21840	COG2992	FlgJ-related protein
IOD25_RS21845	COG1609	Transcriptional regulator
IOD25_RS21845	COG2207	Transcriptional regulator
IOD25_RS21850	COG4214	carbohydrate transport
IOD25_RS21860	COG4213	ABC transporter substrate-binding protein
IOD25_RS21875	COG4682	membrane
IOD25_RS21880	COG4682	membrane
IOD25_RS21885	COG3274	enterobacterial common antigen metabolic process
IOD25_RS21940	COG1278	Cold shock
IOD25_RS21945	COG2944	sequence-specific DNA binding
IOD25_RS21950	COG2814	Major facilitator Superfamily
IOD25_RS21970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOD25_RS21980	COG1609	Transcriptional regulator
IOD25_RS21985	COG2885	chlorophyll binding
IOD25_RS21990	COG0243	molybdopterin cofactor binding
IOD25_RS21995	COG0456	acetyltransferase
IOD25_RS22000	COG2818	Glycosylase
IOD25_RS22005	COG5571	outer membrane autotransporter
IOD25_RS22010	COG2223	nitrite transmembrane transporter activity
IOD25_RS22035	COG0747	negative chemotaxis
IOD25_RS22040	COG0601	transmembrane transport
IOD25_RS22045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOD25_RS22050	COG0444	Belongs to the ABC transporter superfamily
IOD25_RS22055	COG4608	Belongs to the ABC transporter superfamily
IOD25_RS22075	COG2894	cell division
IOD25_RS22085	COG1215	transferase activity, transferring glycosyl groups
IOD25_RS22090	COG0457	Tetratricopeptide repeat
IOD25_RS22105	COG2194	sulfuric ester hydrolase activity
IOD25_RS22135	COG1215	transferase activity, transferring glycosyl groups
IOD25_RS22140	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
IOD25_RS22145	COG0457	Tetratricopeptide repeat
IOD25_RS22145	COG3118	belongs to the thioredoxin family
IOD25_RS22150	COG2200	EAL domain
IOD25_RS22150	COG2199	diguanylate cyclase activity
IOD25_RS22160	COG0612	Peptidase, M16
IOD25_RS22170	COG2982	Protein involved in outer membrane biogenesis
IOD25_RS22175	COG0477	Major facilitator Superfamily
IOD25_RS22180	COG1295	ribonuclease BN
IOD25_RS22190	COG1028	Short-chain dehydrogenase reductase Sdr
IOD25_RS22195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IOD25_RS22205	COG1454	alcohol dehydrogenase
IOD25_RS22215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IOD25_RS22220	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IOD25_RS22225	COG0671	phosphoesterase, PA-phosphatase related
IOD25_RS22245	COG0589	response to stress
IOD25_RS22255	COG0306	phosphate transporter
IOD25_RS22260	COG2081	HI0933 family
IOD25_RS22265	COG2239	Acts as a magnesium transporter
IOD25_RS22275	COG1124	(ABC) transporter
IOD25_RS22285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOD25_RS22290	COG0601	transmembrane transport
IOD25_RS22295	COG0747	negative chemotaxis
IOD25_RS22305	COG3479	Phenolic acid decarboxylase
IOD25_RS22345	COG0628	permease
IOD25_RS22350	COG0477	Major facilitator Superfamily
IOD25_RS22360	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IOD25_RS22375	COG3714	YhhN family
IOD25_RS22385	COG3776	membrane
IOD25_RS22390	COG0742	ribosomal rna small subunit methyltransferase
IOD25_RS22395	COG0552	protein localization to endoplasmic reticulum
IOD25_RS22400	COG2884	Cell division ATP-binding protein ftsE
IOD25_RS22405	COG2177	Part of the ABC transporter FtsEX involved in
IOD25_RS22420	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IOD25_RS22430	COG0683	leucine binding
IOD25_RS22440	COG0683	leucine binding
IOD25_RS22445	COG0559	Belongs to the binding-protein-dependent transport system permease family
IOD25_RS22495	COG0584	glycerophosphoryl diester phosphodiesterase
IOD25_RS22505	COG0405	Gamma-glutamyltransferase
IOD25_RS22510	COG1247	-acetyltransferase
IOD25_RS22520	COG0673	inositol 2-dehydrogenase activity
IOD25_RS22525	COG1741	Belongs to the pirin family
IOD25_RS22530	COG1609	Transcriptional regulator
IOD25_RS22535	COG3265	gluconokinase activity
IOD25_RS22540	COG2610	gluconate transmembrane transporter activity
IOD25_RS22550	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IOD25_RS22575	COG0058	SHG alpha-glucan phosphorylase activity
IOD25_RS22590	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IOD25_RS22605	COG1349	DNA-binding transcription factor activity
IOD25_RS22615	COG0058	SHG alpha-glucan phosphorylase activity
IOD25_RS22620	COG1640	4-alpha-glucanotransferase
IOD25_RS22625	COG2610	gluconate transmembrane transporter activity
IOD25_RS22635	COG1040	competence protein
IOD25_RS22660	COG1918	ferrous iron import across plasma membrane
IOD25_RS22665	COG2183	response to ionizing radiation
IOD25_RS22670	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IOD25_RS22695	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IOD25_RS22700	COG1011	Hydrolase
IOD25_RS22710	COG0494	nUDIX hydrolase
IOD25_RS22715	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IOD25_RS22740	COG4796	Type ii and iii secretion system protein
IOD25_RS22755	COG3266	domain, Protein
IOD25_RS22760	COG0338	D12 class N6 adenine-specific DNA methyltransferase
IOD25_RS22765	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IOD25_RS22790	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IOD25_RS22795	COG0402	S-adenosylhomocysteine deaminase activity
IOD25_RS22800	COG0738	Major facilitator superfamily
IOD25_RS22825	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IOD25_RS22830	COG1289	transmembrane transporter activity
IOD25_RS22840	COG1765	OsmC-like protein
IOD25_RS22845	COG3954	Phosphoribulokinase
IOD25_RS22855	COG0429	hydrolase of the alpha beta-hydrolase fold
IOD25_RS22860	COG0488	(ABC) transporter
IOD25_RS22875	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
IOD25_RS22880	COG1047	Peptidyl-prolyl cis-trans
IOD25_RS22890	COG0545	Peptidyl-prolyl cis-trans isomerase
IOD25_RS22895	COG2964	Protein conserved in bacteria
IOD25_RS22950	COG0051	transcription antitermination factor activity, RNA binding
IOD25_RS22975	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IOD25_RS22990	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IOD25_RS23055	COG0201	protein transport
IOD25_RS23080	COG0202	RNA polymerase activity
IOD25_RS23095	COG0789	Transcriptional regulator
IOD25_RS23100	COG3036	rescue of stalled ribosome
IOD25_RS23130	COG0758	DNA mediated transformation
IOD25_RS23140	COG0551	DNA topoisomerase type I activity
IOD25_RS23160	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IOD25_RS23195	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IOD25_RS23200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOD25_RS23205	COG1309	transcriptional regulator
IOD25_RS23225	COG4145	pantothenate transmembrane transporter activity
IOD25_RS23230	COG3924	membrane
IOD25_RS23235	COG0439	Biotin carboxylase
IOD25_RS23240	COG0511	ligase activity, forming carbon-carbon bonds
IOD25_RS23265	COG2199	diguanylate cyclase activity
IOD25_RS23265	COG2200	EAL domain
IOD25_RS23270	COG1077	Cell shape determining protein MreB Mrl
IOD25_RS23275	COG1792	Involved in formation and maintenance of cell shape
IOD25_RS23280	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IOD25_RS23290	COG1530	ribonuclease E activity
IOD25_RS23295	COG3164	Protein of unknown function
IOD25_RS23300	COG0312	modulator of DNA gyrase
IOD25_RS23305	COG0583	DNA-binding transcription factor activity
IOD25_RS23320	COG1289	transmembrane transporter activity
IOD25_RS23325	COG2732	(Barnase) inhibitor
IOD25_RS23350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IOD25_RS23355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IOD25_RS23360	COG3105	Protein conserved in bacteria
IOD25_RS23365	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IOD25_RS23385	COG0625	glutathione transferase activity
IOD25_RS23390	COG2969	positive regulation of protein catabolic process
IOD25_RS23400	COG0493	'glutamate synthase
IOD25_RS23405	COG0070	glutamate synthase
IOD25_RS23405	COG0069	glutamate synthase activity
IOD25_RS23405	COG0067	glutamate synthase
IOD25_RS23410	COG1242	4 iron, 4 sulfur cluster binding
IOD25_RS23415	COG2271	Major facilitator Superfamily
IOD25_RS23420	COG1063	alcohol dehydrogenase
IOD25_RS23425	COG1312	Catalyzes the dehydration of D-mannonate
IOD25_RS23430	COG5002	protein histidine kinase activity
IOD25_RS23430	COG2198	Histidine kinase
IOD25_RS23430	COG0784	Response regulator, receiver
IOD25_RS23435	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
IOD25_RS23440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IOD25_RS23445	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD25_RS23455	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD25_RS23460	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IOD25_RS23465	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IOD25_RS23470	COG1137	ATPase activity
IOD25_RS23475	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IOD25_RS23480	COG3117	lipopolysaccharide transmembrane transporter activity
IOD25_RS23485	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IOD25_RS23495	COG0530	calcium, potassium:sodium antiporter activity
IOD25_RS23500	COG1127	ABC transporter
IOD25_RS23505	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IOD25_RS23510	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IOD25_RS23515	COG2854	intermembrane phospholipid transfer
IOD25_RS23520	COG3113	response to antibiotic
IOD25_RS23525	COG5007	Belongs to the BolA IbaG family
IOD25_RS23535	COG3423	Transcriptional regulator
IOD25_RS23540	COG0142	geranyltranstransferase activity
IOD25_RS23555	COG0697	spore germination
IOD25_RS23565	COG2027	D-alanyl-D-alanine carboxypeptidase
IOD25_RS23575	COG1534	Rna-binding protein
IOD25_RS23585	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IOD25_RS23590	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IOD25_RS23600	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IOD25_RS23640	COG0195	Participates in both transcription termination and antitermination
IOD25_RS23685	COG0814	amino acid
IOD25_RS23710	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
IOD25_RS23755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD25_RS23760	COG0826	peptidase U32
IOD25_RS23765	COG0826	peptidase U32
IOD25_RS23770	COG3154	lipid carrier protein
IOD25_RS23775	COG3153	acetyltransferase
IOD25_RS23790	COG0693	protein deglycase activity
IOD25_RS23795	COG0702	epimerase
IOD25_RS23800	COG0701	Predicted permease
IOD25_RS23805	COG2823	Periplasmic or secreted lipoprotein
IOD25_RS23825	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IOD25_RS23830	COG2721	sulfolactate sulfo-lyase activity
IOD25_RS23835	COG2271	Major facilitator Superfamily
IOD25_RS23845	COG2084	Dehydrogenase
IOD25_RS23850	COG1929	Belongs to the glycerate kinase type-1 family
IOD25_RS23875	COG1741	Belongs to the pirin family
IOD25_RS23880	COG0583	DNA-binding transcription factor activity
IOD25_RS23885	COG3152	Membrane
IOD25_RS23890	COG0435	Glutathione S-transferase
IOD25_RS23895	COG2259	Doxx family
IOD25_RS23905	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
IOD25_RS23910	COG4575	ribosome binding
IOD25_RS23915	COG1422	Protein of unknown function (DUF1090)
IOD25_RS23925	COG0586	Pfam SNARE associated Golgi protein
IOD25_RS23930	COG2186	Transcriptional regulator
IOD25_RS23935	COG2271	Major facilitator Superfamily
IOD25_RS23945	COG2721	sulfolactate sulfo-lyase activity
IOD25_RS23960	COG0861	Integral membrane protein TerC family
IOD25_RS23965	COG0673	inositol 2-dehydrogenase activity
IOD25_RS23970	COG1451	nucleotide metabolic process
IOD25_RS23990	COG0446	pyridine nucleotide-disulphide oxidoreductase
IOD25_RS23990	COG1902	pentaerythritol trinitrate reductase activity
IOD25_RS24040	COG1695	Transcriptional regulator
IOD25_RS24045	COG2375	cellular response to nickel ion
IOD25_RS24060	COG1461	Dihydroxyacetone kinase
IOD25_RS24065	COG2376	Dihydroxyacetone kinase
IOD25_RS24135	COG3247	response to pH
IOD25_RS24145	COG2198	Histidine kinase
IOD25_RS24145	COG2205	protein histidine kinase activity
IOD25_RS24145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD25_RS24145	COG0784	Response regulator, receiver
IOD25_RS24160	COG2197	response regulator
IOD25_RS24185	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IOD25_RS24190	COG0358	DNA primase activity
IOD25_RS24195	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IOD25_RS24260	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IOD25_RS24275	COG4991	sh3 domain protein
IOD25_RS24280	COG3025	triphosphatase activity
IOD25_RS24305	COG2960	long-chain fatty acid transporting porin activity
IOD25_RS24320	COG3384	dioxygenase
IOD25_RS24325	COG0754	glutathionylspermidine amidase activity
IOD25_RS24340	COG0494	nUDIX hydrolase
IOD25_RS24345	COG3151	Protein conserved in bacteria
IOD25_RS24350	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IOD25_RS24355	COG3150	esterase
IOD25_RS24365	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
IOD25_RS24370	COG2249	NAD(P)H dehydrogenase (quinone) activity
IOD25_RS24375	COG0642	Histidine kinase
IOD25_RS24385	COG3111	PFAM Bacterial OB fold (BOF) protein
IOD25_RS24390	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
IOD25_RS24395	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IOD25_RS24400	COG0204	Acyl-transferase
IOD25_RS24405	COG2132	Multicopper oxidase
IOD25_RS24410	COG1032	radical SAM domain protein
IOD25_RS24420	COG0656	L-ascorbic acid biosynthetic process
IOD25_RS24425	COG1979	alcohol dehydrogenase
IOD25_RS24430	COG2207	Transcriptional regulator
IOD25_RS24435	COG0586	Pfam SNARE associated Golgi protein
IOD25_RS24440	COG0626	cystathionine gamma-synthase activity
IOD25_RS24450	COG0848	biopolymer transport protein
IOD25_RS24455	COG2211	Major facilitator Superfamily
IOD25_RS24480	COG0625	glutathione transferase activity
IOD25_RS24495	COG0754	glutathionylspermidine amidase activity
IOD25_RS24500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOD25_RS24520	COG0583	DNA-binding transcription factor activity
IOD25_RS24525	COG0626	cystathionine gamma-synthase activity
IOD25_RS24565	COG1811	Na channel or pump
IOD25_RS24570	COG1982	Orn Lys Arg decarboxylase major
IOD25_RS24575	COG2211	Major facilitator Superfamily
IOD25_RS24590	COG1194	a g-specific adenine glycosylase
IOD25_RS24600	COG3171	Protein conserved in bacteria
IOD25_RS24610	COG4214	carbohydrate transport
IOD25_RS24625	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IOD25_RS24640	COG0762	integral membrane protein
IOD25_RS24645	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IOD25_RS24650	COG2805	Type II/IV secretion system protein
IOD25_RS24670	COG0189	ligase activity
IOD25_RS24675	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IOD25_RS24680	COG2356	endonuclease I
IOD25_RS24690	COG2814	Major facilitator Superfamily
IOD25_RS24725	COG0501	Belongs to the peptidase M48B family
IOD25_RS24730	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IOD25_RS24745	COG0191	fructose-bisphosphate aldolase activity
IOD25_RS24750	COG0668	transmembrane transport
IOD25_RS24760	COG2968	Membrane
IOD25_RS24775	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IOD25_RS24780	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IOD25_RS24800	COG0006	proline dipeptidase activity
IOD25_RS24805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOD25_RS24810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOD25_RS24830	COG1028	Short-chain dehydrogenase reductase Sdr
IOD25_RS24840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IOD25_RS24860	COG2723	6-phospho-beta-galactosidase activity
IOD25_RS24865	COG1737	Transcriptional regulator
IOD25_RS24875	COG1272	protein, Hemolysin III
IOD25_RS24885	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IOD25_RS24895	COG0716	FMN binding
IOD25_RS24900	COG4974	Belongs to the 'phage' integrase family
IOD25_RS24910	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IOD25_RS24930	COG4942	peptidase
IOD25_RS24940	COG2814	Major facilitator Superfamily
IOD25_RS24955	COG0667	Aldo Keto reductase
IOD25_RS24990	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IOD25_RS24995	COG1393	Belongs to the ArsC family
IOD25_RS25010	COG1538	Outer membrane efflux protein
IOD25_RS25015	COG1289	transmembrane transporter activity
IOD25_RS25030	COG3592	Divergent 4Fe-4S mono-cluster
IOD25_RS25035	COG2388	GCN5-related N-acetyl-transferase
IOD25_RS25045	COG3539	Fimbrial protein
IOD25_RS25050	COG3539	Fimbrial protein
IOD25_RS25055	COG3539	Fimbrial protein
IOD25_RS25060	COG3188	usher protein
IOD25_RS25065	COG3121	Chaperone
IOD25_RS25070	COG3539	Fimbrial protein
IOD25_RS25080	COG4974	Belongs to the 'phage' integrase family
IOD25_RS25085	COG0582	viral genome integration into host DNA
IOD25_RS25090	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
IOD25_RS25095	COG1846	Transcriptional regulator
IOD25_RS25100	COG0697	spore germination
IOD25_RS25150	COG0667	Aldo Keto reductase
IOD25_RS25155	COG0814	amino acid
IOD25_RS25170	COG0183	Belongs to the thiolase family
IOD25_RS25180	COG0823	Involved in the tonB-independent uptake of proteins
IOD25_RS25185	COG1028	Short-chain dehydrogenase reductase Sdr
IOD25_RS25190	COG2814	Major facilitator Superfamily
IOD25_RS25225	COG3842	ATPase activity
IOD25_RS25230	COG0395	ABC-type sugar transport system, permease component
IOD25_RS25235	COG1175	transmembrane transport
IOD25_RS25240	COG1917	Cupin 2, conserved barrel domain protein
IOD25_RS25245	COG1794	racemase activity, acting on amino acids and derivatives
IOD25_RS25250	COG0583	DNA-binding transcription factor activity
IOD25_RS25260	COG1609	Transcriptional regulator
IOD25_RS25265	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IOD25_RS25270	COG2723	6-phospho-beta-galactosidase activity
IOD25_RS25275	COG2186	Transcriptional regulator
IOD25_RS25285	COG1609	Transcriptional regulator
IOD25_RS25305	COG0667	Aldo Keto reductase
IOD25_RS25315	COG0861	Integral membrane protein TerC family
IOD25_RS25350	COG2165	general secretion pathway protein
IOD25_RS25355	COG4795	General secretion pathway protein
IOD25_RS25365	COG4967	type IV pilus modification protein PilV
IOD25_RS25370	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IOD25_RS25375	COG1025	Belongs to the peptidase M16 family
IOD25_RS25380	COG1074	ATP-dependent DNA helicase activity
IOD25_RS25385	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IOD25_RS25395	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IOD25_RS25395	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IOD25_RS25400	COG0860	N-Acetylmuramoyl-L-alanine amidase
IOD25_RS25405	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IOD25_RS25435	COG4656	Part of a membrane complex involved in electron transport
IOD25_RS25440	COG1454	alcohol dehydrogenase
IOD25_RS25440	COG1012	belongs to the aldehyde dehydrogenase family
IOD25_RS25470	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
IOD25_RS25635	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
IOD25_RS25640	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IOD25_RS25645	COG2166	iron-sulfur cluster assembly
IOD25_RS25650	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IOD25_RS25660	COG0583	DNA-binding transcription factor activity
IOD25_RS25665	COG2363	Small membrane protein
IOD25_RS25675	COG1349	DNA-binding transcription factor activity
IOD25_RS25695	COG0738	Major facilitator superfamily
IOD25_RS25700	COG0235	Class ii aldolase
IOD25_RS25705	COG1454	alcohol dehydrogenase
IOD25_RS25725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD25_RS25740	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IOD25_RS25745	COG2011	ABC-type metal ion transport system permease component
IOD25_RS25750	COG1464	Belongs to the NlpA lipoprotein family
IOD25_RS25755	COG0477	Major facilitator Superfamily
IOD25_RS25765	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IOD25_RS25770	COG1760	l-serine dehydratase
IOD25_RS25795	COG5499	transcription regulator containing HTH domain
IOD25_RS25800	COG4680	protein conserved in bacteria
IOD25_RS25815	COG3436	PFAM IS66 Orf2 family protein
IOD25_RS25845	COG2205	protein histidine kinase activity
IOD25_RS25850	COG0745	RESPONSE REGULATOR receiver
IOD25_RS25855	COG1276	copper resistance
IOD25_RS25860	COG2372	response to copper ion
IOD25_RS25865	COG3667	copper resistance
IOD25_RS25880	COG0739	heme binding
IOD25_RS25910	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOD25_RS26090	COG3436	PFAM IS66 Orf2 family protein
IOD25_RS26095	COG4372	Transposase
IOD25_RS26150	COG3344	reverse transcriptase
IOD25_RS26235	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IOD25_RS26240	COG1842	Phage shock protein A
IOD25_RS26250	COG1983	PspC domain protein
IOD25_RS26305	COG1695	Transcriptional regulator
IOD25_RS26330	COG3173	Aminoglycoside phosphotransferase
IOD25_RS26375	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
IOD25_RS26425	COG5642	Protein of unknown function (DUF2384)
IOD25_RS26430	COG5654	RES domain protein
IOD25_RS26440	COG2963	transposase activity
IOD25_RS26450	COG2801	Transposase and inactivated derivatives
IOD25_RS26455	COG0431	NADPH-dependent FMN reductase
IOD25_RS26460	COG0640	Transcriptional regulator
IOD25_RS26510	COG0732	type I restriction modification DNA specificity domain
IOD25_RS26545	COG2801	Transposase and inactivated derivatives
IOD25_RS26580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOD25_RS26590	COG2801	Transposase and inactivated derivatives
IOD25_RS26630	COG5499	transcription regulator containing HTH domain
IOD25_RS26635	COG4680	protein conserved in bacteria
IOD25_RS26650	COG3436	PFAM IS66 Orf2 family protein
IOD25_RS26685	COG0745	RESPONSE REGULATOR receiver
IOD25_RS26695	COG2372	response to copper ion
IOD25_RS26715	COG0739	heme binding
IOD25_RS26745	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOD25_RS26950	COG1475	DNA binding
IOD25_RS26990	COG2894	cell division
IOD25_RS27000	COG1215	transferase activity, transferring glycosyl groups
IOD25_RS27005	COG0457	Tetratricopeptide repeat
IOD25_RS27020	COG2194	sulfuric ester hydrolase activity
IOD25_RS27050	COG5499	transcription regulator containing HTH domain
IOD25_RS27245	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
IOD25_RS27270	COG3318	Belongs to the UPF0149 family
IOD25_RS27270	COG3012	SEC-C Motif Domain Protein
IOD25_RS27275	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IOD25_RS27325	COG3436	PFAM IS66 Orf2 family protein
IOD25_RS27330	COG4372	Transposase
IOD25_RS27370	COG0484	heat shock protein binding
IOD25_RS27400	COG2801	Transposase and inactivated derivatives
IOD25_RS27410	COG2801	Transposase and inactivated derivatives
IOD25_RS27520	COG0697	spore germination
IOD25_RS27535	COG0768	penicillin binding
IOD25_RS27580	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IOD25_RS27655	COG1192	Involved in chromosome partitioning
IOD25_RS27670	COG3344	reverse transcriptase
IOD25_RS27740	COG3039	Transposase
IOD25_RS27760	COG1716	ATPase activity
IOD25_RS27760	COG5001	Diguanylate cyclase
IOD25_RS27770	COG3039	Transposase
IOD25_RS27785	COG3436	PFAM IS66 Orf2 family protein
IOD25_RS27790	COG4372	Transposase
IOD25_RS27805	COG3706	GGDEF domain
IOD25_RS28075	COG3300	MHYT domain
IOD25_RS28075	COG5001	Diguanylate cyclase
IOD25_RS28100	COG3436	PFAM IS66 Orf2 family protein
IOD25_RS28340	COG1216	Glycosyl transferase, family 2
IOD25_RS28375	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IOD25_RS28515	COG0668	transmembrane transport
IOD25_RS28520	COG0477	Major facilitator Superfamily