locus-tag	class	description
I5I21_RS00025	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I5I21_RS00055	COG2091	lysine biosynthetic process via aminoadipic acid
I5I21_RS00060	COG0431	NADPH-dependent FMN reductase
I5I21_RS00065	COG2252	PERMEase
I5I21_RS00070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5I21_RS00075	COG0363	glucosamine-6-phosphate deaminase activity
I5I21_RS00080	COG2382	esterase
I5I21_RS00090	COG0704	Plays a role in the regulation of phosphate uptake
I5I21_RS00095	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I5I21_RS00100	COG0581	inorganic phosphate transmembrane transporter activity
I5I21_RS00105	COG0573	inorganic phosphate transmembrane transporter activity
I5I21_RS00110	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I5I21_RS00115	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I5I21_RS00165	COG3312	ion transport
I5I21_RS00180	COG0716	FMN binding
I5I21_RS00185	COG1522	sequence-specific DNA binding
I5I21_RS00215	COG1129	ABC transporter
I5I21_RS00220	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5I21_RS00230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5I21_RS00235	COG1609	Transcriptional regulator
I5I21_RS00240	COG0477	Major facilitator Superfamily
I5I21_RS00245	COG2186	Transcriptional regulator
I5I21_RS00270	COG1763	Mo-molybdopterin cofactor biosynthetic process
I5I21_RS00280	COG3084	Protein conserved in bacteria
I5I21_RS00285	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I5I21_RS00295	COG0204	Acyl-transferase
I5I21_RS00315	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I5I21_RS00330	COG3852	Histidine kinase
I5I21_RS00345	COG1011	Hydrolase
I5I21_RS00360	COG0456	acetyltransferase
I5I21_RS00365	COG0657	acetylesterase activity
I5I21_RS00370	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I5I21_RS00385	COG2864	formate dehydrogenase
I5I21_RS00390	COG0437	4 iron, 4 sulfur cluster binding
I5I21_RS00410	COG0205	6-phosphofructokinase activity
I5I21_RS00470	COG2211	Major facilitator Superfamily
I5I21_RS00480	COG1454	alcohol dehydrogenase
I5I21_RS00485	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5I21_RS00490	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5I21_RS00495	COG1129	ABC transporter
I5I21_RS00535	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I5I21_RS00540	COG2258	MOSC domain
I5I21_RS00545	COG2205	protein histidine kinase activity
I5I21_RS00550	COG0745	RESPONSE REGULATOR receiver
I5I21_RS00555	COG3678	ATP-independent chaperone mediated protein folding
I5I21_RS00575	COG1575	Belongs to the MenA family. Type 1 subfamily
I5I21_RS00590	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I5I21_RS00595	COG1609	Transcriptional regulator
I5I21_RS00600	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I5I21_RS00615	COG0626	cystathionine gamma-synthase activity
I5I21_RS00620	COG0460	homoserine dehydrogenase
I5I21_RS00620	COG0527	aspartate kinase activity
I5I21_RS00630	COG0737	Belongs to the 5'-nucleotidase family
I5I21_RS00640	COG0583	DNA-binding transcription factor activity
I5I21_RS00650	COG0697	spore germination
I5I21_RS00655	COG0371	Dehydrogenase
I5I21_RS00665	COG2207	Transcriptional regulator
I5I21_RS00670	COG3443	Belongs to the bacterial solute-binding protein 9 family
I5I21_RS00685	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I5I21_RS00700	COG0583	DNA-binding transcription factor activity
I5I21_RS00775	COG3085	chromosome segregation
I5I21_RS00795	COG3978	acetolactate synthase activity
I5I21_RS00810	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I5I21_RS00815	COG0583	DNA-binding transcription factor activity
I5I21_RS00825	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5I21_RS00830	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5I21_RS00840	COG1811	Na channel or pump
I5I21_RS00865	COG3118	belongs to the thioredoxin family
I5I21_RS00870	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I5I21_RS00875	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I5I21_RS00885	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I5I21_RS00890	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I5I21_RS00895	COG1088	dTDP-glucose 4,6-dehydratase activity
I5I21_RS00900	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I5I21_RS00905	COG0456	acetyltransferase
I5I21_RS00910	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I5I21_RS00915	COG2244	polysaccharide biosynthetic process
I5I21_RS00960	COG3071	HemY protein
I5I21_RS00965	COG2959	enzyme of heme biosynthesis
I5I21_RS00980	COG3072	Adenylate cyclase
I5I21_RS01010	COG1011	Hydrolase
I5I21_RS01015	COG0210	DNA helicase
I5I21_RS01045	COG1280	lysine exporter protein (LysE YggA)
I5I21_RS01055	COG1280	lysine exporter protein (LysE YggA)
I5I21_RS01060	COG2267	carboxylic ester hydrolase activity
I5I21_RS01065	COG0561	phosphatase activity
I5I21_RS01070	COG0697	spore germination
I5I21_RS01075	COG0583	DNA-binding transcription factor activity
I5I21_RS01105	COG3165	ubiquinone biosynthetic process from chorismate
I5I21_RS01125	COG0805	protein transport
I5I21_RS01165	COG1739	Uncharacterized protein family UPF0029
I5I21_RS01175	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I5I21_RS01205	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I5I21_RS01250	COG0250	Participates in transcription elongation, termination and antitermination
I5I21_RS01285	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I5I21_RS01290	COG1447	Phosphotransferase system cellobiose-specific component IIA
I5I21_RS01300	COG3706	GGDEF domain
I5I21_RS01315	COG2104	thiamine diphosphate biosynthetic process
I5I21_RS01320	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I5I21_RS01335	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I5I21_RS01370	COG3678	ATP-independent chaperone mediated protein folding
I5I21_RS01375	COG4191	Histidine kinase
I5I21_RS01385	COG0151	Belongs to the GarS family
I5I21_RS01415	COG0456	acetyltransferase
I5I21_RS01425	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I5I21_RS01455	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I5I21_RS01510	COG0527	aspartate kinase activity
I5I21_RS01520	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I5I21_RS01530	COG0251	oxidation-reduction process
I5I21_RS01600	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I5I21_RS01610	COG0534	Mate efflux family protein
I5I21_RS01620	COG3237	CsbD-like
I5I21_RS01625	COG0735	belongs to the Fur family
I5I21_RS01635	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I5I21_RS01650	COG0305	Participates in initiation and elongation during chromosome replication
I5I21_RS01655	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I5I21_RS01670	COG0432	Pfam Uncharacterised protein family UPF0047
I5I21_RS01675	COG2315	Protein conserved in bacteria
I5I21_RS01690	COG0741	lytic transglycosylase activity
I5I21_RS01695	COG4771	TonB-dependent receptor
I5I21_RS01715	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I5I21_RS01725	COG0483	inositol monophosphate 1-phosphatase activity
I5I21_RS01730	COG1609	Transcriptional regulator
I5I21_RS01735	COG1234	tRNA 3'-trailer cleavage
I5I21_RS01765	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I5I21_RS01775	COG0789	Transcriptional regulator
I5I21_RS01780	COG0625	glutathione transferase activity
I5I21_RS01785	COG2252	PERMEase
I5I21_RS01790	COG0025	NhaP-type Na H and K H
I5I21_RS01795	COG0583	DNA-binding transcription factor activity
I5I21_RS01800	COG1380	Effector of murein hydrolase LrgA
I5I21_RS01805	COG1346	cytolysis
I5I21_RS01810	COG3539	Fimbrial protein
I5I21_RS01840	COG3162	membrane
I5I21_RS01845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I5I21_RS01855	COG1301	dicarboxylic acid transport
I5I21_RS01860	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I5I21_RS01895	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5I21_RS01900	COG1129	ABC transporter
I5I21_RS01905	COG4191	Histidine kinase
I5I21_RS01905	COG0784	Response regulator, receiver
I5I21_RS01915	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I5I21_RS01925	COG3454	Phosphonate metabolism
I5I21_RS01930	COG4778	phosphonate C-P lyase system protein PhnL
I5I21_RS01935	COG4107	phosphonate C-P lyase system protein PhnK
I5I21_RS01940	COG3627	carbon phosphorus lyase activity
I5I21_RS01945	COG3626	phosphonate metabolism
I5I21_RS01950	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I5I21_RS01955	COG3624	Phosphonate C-P lyase system protein PhnG
I5I21_RS01960	COG2188	Transcriptional regulator
I5I21_RS01965	COG2764	glyoxalase bleomycin resistance protein dioxygenase
I5I21_RS01970	COG2824	Alkylphosphonate utilization operon protein PhnA
I5I21_RS01980	COG2169	Transcriptional regulator
I5I21_RS01985	COG1486	melibiose metabolic process
I5I21_RS02030	COG0861	Integral membrane protein TerC family
I5I21_RS02045	COG1215	transferase activity, transferring glycosyl groups
I5I21_RS02050	COG1649	PFAM Uncharacterised BCR, COG1649
I5I21_RS02050	COG0726	polysaccharide deacetylase
I5I21_RS02055	COG0457	Tetratricopeptide repeat
I5I21_RS02085	COG1309	transcriptional regulator
I5I21_RS02100	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I5I21_RS02105	COG1027	Aspartate ammonia-lyase
I5I21_RS02110	COG3030	protein affecting phage T7 exclusion by the F plasmid
I5I21_RS02115	COG0531	amino acid
I5I21_RS02185	COG1509	lysine 2,3-aminomutase activity
I5I21_RS02200	COG5510	response to toxic substance
I5I21_RS02205	COG2076	Multidrug Resistance protein
I5I21_RS02225	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I5I21_RS02230	COG1053	succinate dehydrogenase
I5I21_RS02245	COG3264	Mechanosensitive ion channel
I5I21_RS02245	COG1511	domain protein
I5I21_RS02265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5I21_RS02285	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I5I21_RS02290	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I5I21_RS02290	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I5I21_RS02295	COG0802	atpase or kinase
I5I21_RS02300	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5I21_RS02320	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I5I21_RS02325	COG0330	HflC and HflK could
I5I21_RS02330	COG0330	HflC and HflK could
I5I21_RS02340	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I5I21_RS02355	COG0557	exoribonuclease II activity
I5I21_RS02360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I5I21_RS02365	COG1960	acyl-CoA dehydrogenase activity
I5I21_RS02375	COG3650	response to hydrogen peroxide
I5I21_RS02380	COG1073	alpha beta
I5I21_RS02440	COG2965	DNA replication, synthesis of RNA primer
I5I21_RS02445	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I5I21_RS02455	COG3061	Opacity-associated protein A
I5I21_RS02460	COG0545	Peptidyl-prolyl cis-trans isomerase
I5I21_RS02465	COG1113	amino acid transport
I5I21_RS02475	COG0697	spore germination
I5I21_RS02485	COG0702	epimerase
I5I21_RS02490	COG1733	regulation of RNA biosynthetic process
I5I21_RS02505	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I5I21_RS02520	COG1253	flavin adenine dinucleotide binding
I5I21_RS02530	COG0729	surface antigen
I5I21_RS02535	COG2911	Protein conserved in bacteria
I5I21_RS02540	COG2105	PFAM AIG2 family protein
I5I21_RS02560	COG1879	ABC-type sugar transport system periplasmic component
I5I21_RS02565	COG1129	ABC transporter
I5I21_RS02570	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5I21_RS02575	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5I21_RS02585	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I5I21_RS02610	COG0312	modulator of DNA gyrase
I5I21_RS02650	COG3964	amidohydrolase
I5I21_RS02665	COG2706	6-phosphogluconolactonase activity
I5I21_RS02670	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5I21_RS02670	COG3711	transcriptional antiterminator
I5I21_RS02675	COG3077	Addiction module antitoxin, RelB DinJ family
I5I21_RS02680	COG2026	Addiction module toxin, RelE StbE family
I5I21_RS02685	COG0602	queuosine metabolic process
I5I21_RS02710	COG1486	melibiose metabolic process
I5I21_RS02715	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5I21_RS02720	COG0366	Alpha amylase catalytic
I5I21_RS02725	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5I21_RS02725	COG1263	PTS System
I5I21_RS02760	COG2731	YhcH YjgK YiaL family protein
I5I21_RS02765	COG2222	sugar isomerase
I5I21_RS02770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5I21_RS02775	COG1228	amidohydrolase
I5I21_RS02780	COG1288	antiporter activity
I5I21_RS02785	COG2188	Transcriptional regulator
I5I21_RS02810	COG0525	valine-tRNA ligase activity
I5I21_RS02815	COG2927	DNA polymerase III (CHI subunit)
I5I21_RS02825	COG0795	lipopolysaccharide-transporting ATPase activity
I5I21_RS02830	COG0795	lipopolysaccharide-transporting ATPase activity
I5I21_RS02835	COG0433	COG0433 Predicted ATPase
I5I21_RS02850	COG3718	enzyme involved in inositol metabolism
I5I21_RS02855	COG0837	glucose binding
I5I21_RS02855	COG1737	Transcriptional regulator
I5I21_RS02860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5I21_RS02865	COG3962	Belongs to the TPP enzyme family
I5I21_RS02875	COG1082	Xylose isomerase domain protein TIM barrel
I5I21_RS02885	COG1653	transport
I5I21_RS02890	COG3842	ATPase activity
I5I21_RS02895	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I5I21_RS02900	COG0395	ABC-type sugar transport system, permease component
I5I21_RS02905	COG1175	transmembrane transport
I5I21_RS02910	COG1064	alcohol dehydrogenase
I5I21_RS02915	COG0659	secondary active sulfate transmembrane transporter activity
I5I21_RS02920	COG0288	reversible hydration of carbon dioxide
I5I21_RS02930	COG0582	viral genome integration into host DNA
I5I21_RS03035	COG3507	Belongs to the glycosyl hydrolase 43 family
I5I21_RS03040	COG2211	Major facilitator Superfamily
I5I21_RS03050	COG4580	involved in the transport of maltose and maltodextrins
I5I21_RS03055	COG3272	Protein of unknown function (DUF1722)
I5I21_RS03075	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I5I21_RS03090	COG0300	oxidoreductase activity
I5I21_RS03100	COG0789	Transcriptional regulator
I5I21_RS03105	COG3040	lipid binding
I5I21_RS03115	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5I21_RS03120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5I21_RS03125	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5I21_RS03130	COG1538	Outer membrane efflux protein
I5I21_RS03135	COG0745	RESPONSE REGULATOR receiver
I5I21_RS03140	COG5002	protein histidine kinase activity
I5I21_RS03155	COG2850	peptidyl-arginine hydroxylation
I5I21_RS03185	COG0842	Transport permease protein
I5I21_RS03190	COG1129	ABC transporter
I5I21_RS03190	COG0842	Transport permease protein
I5I21_RS03195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5I21_RS03205	COG1879	ABC-type sugar transport system periplasmic component
I5I21_RS03210	COG1129	ABC transporter
I5I21_RS03215	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5I21_RS03225	COG2249	NAD(P)H dehydrogenase (quinone) activity
I5I21_RS03230	COG0583	DNA-binding transcription factor activity
I5I21_RS03240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5I21_RS03245	COG5457	Domain of unknown function (DUF1127)
I5I21_RS03255	COG1566	PFAM secretion protein HlyD family protein
I5I21_RS03270	COG1924	4 iron, 4 sulfur cluster binding
I5I21_RS03275	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I5I21_RS03290	COG2733	membrane
I5I21_RS03300	COG2207	Transcriptional regulator
I5I21_RS03300	COG1917	Cupin 2, conserved barrel domain protein
I5I21_RS03305	COG5464	transposase or invertase
I5I21_RS03310	COG1012	belongs to the aldehyde dehydrogenase family
I5I21_RS03320	COG0523	cobalamin synthesis protein
I5I21_RS03325	COG2879	small protein
I5I21_RS03330	COG1966	Carbon starvation protein
I5I21_RS03345	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I5I21_RS03350	COG2368	4-hydroxyphenylacetate
I5I21_RS03370	COG3971	2-oxopent-4-enoate hydratase activity
I5I21_RS03380	COG3384	dioxygenase
I5I21_RS03385	COG1012	belongs to the aldehyde dehydrogenase family
I5I21_RS03395	COG0179	Fumarylacetoacetate (FAA) hydrolase
I5I21_RS03405	COG1846	Transcriptional regulator
I5I21_RS03435	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I5I21_RS03450	COG3734	2-keto-3-deoxy-galactonokinase
I5I21_RS03455	COG0800	Aldolase
I5I21_RS03460	COG1737	Transcriptional regulator
I5I21_RS03470	COG0456	acetyltransferase
I5I21_RS03470	COG1214	PFAM Peptidase M22, glycoprotease
I5I21_RS03475	COG2271	Major facilitator Superfamily
I5I21_RS03480	COG1802	Transcriptional regulator
I5I21_RS03485	COG1063	alcohol dehydrogenase
I5I21_RS03495	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I5I21_RS03495	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I5I21_RS03510	COG3715	PTS system
I5I21_RS03515	COG3716	PTS system mannose fructose sorbose family IID component
I5I21_RS03520	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I5I21_RS03530	COG5464	transposase or invertase
I5I21_RS03545	COG1484	DNA-dependent DNA replication
I5I21_RS03560	COG2966	Psort location CytoplasmicMembrane, score
I5I21_RS03575	COG2197	response regulator
I5I21_RS03580	COG2197	response regulator
I5I21_RS03585	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I5I21_RS03590	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5I21_RS03590	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5I21_RS03595	COG4114	ferric iron reductase
I5I21_RS03600	COG3706	GGDEF domain
I5I21_RS03635	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I5I21_RS03640	COG0456	acetyltransferase
I5I21_RS03645	COG1011	Hydrolase
I5I21_RS03655	COG2823	Periplasmic or secreted lipoprotein
I5I21_RS03665	COG4667	esterase of the alpha-beta hydrolase superfamily
I5I21_RS03670	COG0084	hydrolase, TatD family'
I5I21_RS03675	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I5I21_RS03705	COG3726	membrane protein affecting hemolysin expression
I5I21_RS03710	COG0560	Phosphoserine phosphatase
I5I21_RS03715	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I5I21_RS03725	COG0488	(ABC) transporter
I5I21_RS03730	COG0741	lytic transglycosylase activity
I5I21_RS03750	COG2207	Transcriptional regulator
I5I21_RS03750	COG3708	Transcriptional regulator
I5I21_RS03755	COG3045	CreA protein
I5I21_RS03760	COG0745	RESPONSE REGULATOR receiver
I5I21_RS03765	COG2205	protein histidine kinase activity
I5I21_RS03770	COG4452	Inner membrane protein CreD
I5I21_RS03775	COG0745	RESPONSE REGULATOR receiver
I5I21_RS03785	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I5I21_RS03795	COG0527	aspartate kinase activity
I5I21_RS03795	COG0460	homoserine dehydrogenase
I5I21_RS03805	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I5I21_RS03820	COG1115	amino acid carrier protein
I5I21_RS03825	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I5I21_RS03830	COG0521	Mo-molybdopterin cofactor biosynthetic process
I5I21_RS03835	COG0477	Major facilitator Superfamily
I5I21_RS03840	COG1584	GPR1 FUN34 yaaH family protein
I5I21_RS03845	COG4735	regulation of single-species biofilm formation
I5I21_RS03870	COG0583	DNA-binding transcription factor activity
I5I21_RS03880	COG0196	riboflavin kinase activity
I5I21_RS03895	COG1047	Peptidyl-prolyl cis-trans
I5I21_RS03920	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I5I21_RS03985	COG0505	Belongs to the CarA family
I5I21_RS04030	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I5I21_RS04040	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I5I21_RS04045	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I5I21_RS04060	COG3493	citrate carrier protein
I5I21_RS04070	COG0564	pseudouridine synthase activity
I5I21_RS04080	COG0417	DNA replication proofreading
I5I21_RS04085	COG0235	Class ii aldolase
I5I21_RS04105	COG0586	Pfam SNARE associated Golgi protein
I5I21_RS04115	COG1178	ABC-type Fe3 transport system permease component
I5I21_RS04135	COG2814	Major facilitator Superfamily
I5I21_RS04140	COG2271	Major facilitator Superfamily
I5I21_RS04145	COG0583	DNA-binding transcription factor activity
I5I21_RS04155	COG0738	Major facilitator superfamily
I5I21_RS04200	COG0028	Belongs to the TPP enzyme family
I5I21_RS04210	COG1609	Transcriptional regulator
I5I21_RS04230	COG0768	penicillin binding
I5I21_RS04235	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I5I21_RS04240	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I5I21_RS04255	COG0772	Belongs to the SEDS family
I5I21_RS04280	COG0849	cell division
I5I21_RS04285	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I5I21_RS04305	COG0494	nUDIX hydrolase
I5I21_RS04330	COG1459	type II secretion system
I5I21_RS04335	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I5I21_RS04340	COG4969	Belongs to the N-Me-Phe pilin family
I5I21_RS04350	COG3023	N-Acetylmuramoyl-L-alanine amidase
I5I21_RS04355	COG3725	Membrane protein required for beta-lactamase induction
I5I21_RS04360	COG3940	Belongs to the glycosyl hydrolase 43 family
I5I21_RS04365	COG2211	Major facilitator Superfamily
I5I21_RS04370	COG1113	amino acid transport
I5I21_RS04375	COG2186	Transcriptional regulator
I5I21_RS04380	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I5I21_RS04385	COG0508	dehydrogenase complex catalyzes the overall conversion of
I5I21_RS04390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5I21_RS04405	COG3064	Membrane
I5I21_RS04455	COG2132	Multicopper oxidase
I5I21_RS04460	COG4993	Dehydrogenase
I5I21_RS04475	COG0288	reversible hydration of carbon dioxide
I5I21_RS04480	COG1131	(ABC) transporter
I5I21_RS04485	COG0842	Transport permease protein
I5I21_RS04490	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5I21_RS04495	COG0726	polysaccharide deacetylase
I5I21_RS04515	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I5I21_RS04520	COG0617	tRNA 3'-terminal CCA addition
I5I21_RS04540	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I5I21_RS04545	COG1643	Atp-dependent helicase
I5I21_RS04640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I5I21_RS04645	COG4774	siderophore transport
I5I21_RS04650	COG1120	ATPase activity
I5I21_RS04655	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I5I21_RS04660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5I21_RS04680	COG2860	membrane
I5I21_RS04700	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5I21_RS04705	COG3835	regulator
I5I21_RS04720	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I5I21_RS04725	COG0024	Methionine aminopeptidase
I5I21_RS04750	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I5I21_RS04760	COG0575	Belongs to the CDS family
I5I21_RS04765	COG0750	zinc metalloprotease
I5I21_RS04775	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I5I21_RS04815	COG1982	Orn Lys Arg decarboxylase major
I5I21_RS04820	COG0346	lactoylglutathione lyase activity
I5I21_RS04830	COG4568	rho-dependent transcription termination
I5I21_RS04845	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I5I21_RS04850	COG3015	lipoprotein NlpE involved in copper resistance
I5I21_RS04855	COG0791	NLP P60 protein
I5I21_RS04865	COG1720	tRNA m6t6A37 methyltransferase activity
I5I21_RS04875	COG1464	Belongs to the NlpA lipoprotein family
I5I21_RS04880	COG2011	ABC-type metal ion transport system permease component
I5I21_RS04890	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I5I21_RS04925	COG0656	L-ascorbic acid biosynthetic process
I5I21_RS04930	COG0583	DNA-binding transcription factor activity
I5I21_RS04935	COG2814	Major facilitator Superfamily
I5I21_RS04945	COG2226	methyltransferase
I5I21_RS04950	COG1388	LysM domain
I5I21_RS04950	COG0741	lytic transglycosylase activity
I5I21_RS04960	COG2226	methyltransferase
I5I21_RS04970	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I5I21_RS04980	COG0583	DNA-binding transcription factor activity
I5I21_RS04990	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I5I21_RS04995	COG1960	acyl-CoA dehydrogenase activity
I5I21_RS05005	COG0121	glutamine amidotransferase
I5I21_RS05010	COG3034	peptidoglycan biosynthetic process
I5I21_RS05025	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I5I21_RS05030	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I5I21_RS05045	COG2991	Protein conserved in bacteria
I5I21_RS05060	COG0454	-acetyltransferase
I5I21_RS05065	COG2195	Cleaves the N-terminal amino acid of tripeptides
I5I21_RS05085	COG1802	Transcriptional regulator
I5I21_RS05090	COG1113	amino acid transport
I5I21_RS05095	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I5I21_RS05100	COG1012	belongs to the aldehyde dehydrogenase family
I5I21_RS05105	COG0579	oxidoreductase
I5I21_RS05120	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I5I21_RS05125	COG0625	glutathione transferase activity
I5I21_RS05130	COG3775	system Galactitol-specific IIC component
I5I21_RS05135	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5I21_RS05140	COG1028	Short-chain dehydrogenase reductase Sdr
I5I21_RS05145	COG1070	Carbohydrate kinase
I5I21_RS05165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5I21_RS05170	COG0508	dehydrogenase complex catalyzes the overall conversion of
I5I21_RS05175	COG0022	dehydrogenase e1 component
I5I21_RS05180	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I5I21_RS05240	COG1192	Involved in chromosome partitioning
I5I21_RS05245	COG0582	viral genome integration into host DNA
I5I21_RS05270	COG0791	NLP P60 protein
I5I21_RS05290	COG3639	organic phosphonate transmembrane transporter activity
I5I21_RS05300	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I5I21_RS05325	COG3188	usher protein
I5I21_RS05340	COG0765	amino acid transport
I5I21_RS05345	COG0765	amino acid transport
I5I21_RS05350	COG1126	abc transporter atp-binding protein
I5I21_RS05355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5I21_RS05395	COG4302	ethanolamine ammonia-lyase activity
I5I21_RS05400	COG4303	Ethanolamine ammonia lyase large subunit
I5I21_RS05415	COG0833	amino acid
I5I21_RS05420	COG2040	homocysteine
I5I21_RS05425	COG4521	taurine ABC transporter
I5I21_RS05430	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I5I21_RS05435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5I21_RS05440	COG2175	clavaminate synthase activity
I5I21_RS05450	COG0113	porphobilinogen synthase activity
I5I21_RS05455	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I5I21_RS05460	COG1335	isochorismatase
I5I21_RS05465	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I5I21_RS05505	COG1785	Belongs to the alkaline phosphatase family
I5I21_RS05515	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I5I21_RS05525	COG3416	Protein conserved in bacteria
I5I21_RS05530	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I5I21_RS05540	COG4126	flavin adenine dinucleotide binding
I5I21_RS05555	COG1940	carbohydrate kinase activity
I5I21_RS05560	COG0419	ATPase involved in DNA repair
I5I21_RS05565	COG0420	3'-5' exonuclease activity
I5I21_RS05590	COG0366	Alpha amylase catalytic
I5I21_RS05595	COG0583	DNA-binding transcription factor activity
I5I21_RS05600	COG1335	isochorismatase
I5I21_RS05610	COG1228	amidohydrolase
I5I21_RS05620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5I21_RS05635	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5I21_RS05645	COG0450	alkyl hydroperoxide reductase
I5I21_RS05670	COG1862	Preprotein translocase
I5I21_RS05675	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I5I21_RS05680	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I5I21_RS05700	COG4238	major outer membrane lipoprotein
I5I21_RS05710	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I5I21_RS05710	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I5I21_RS05730	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I5I21_RS05735	COG0667	Aldo Keto reductase
I5I21_RS05745	COG0142	geranyltranstransferase activity
I5I21_RS05765	COG0693	protein deglycase activity
I5I21_RS05770	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I5I21_RS05780	COG2814	Major facilitator Superfamily
I5I21_RS05785	COG0673	inositol 2-dehydrogenase activity
I5I21_RS05800	COG1053	succinate dehydrogenase
I5I21_RS05810	COG1053	succinate dehydrogenase
I5I21_RS05815	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I5I21_RS05820	COG1414	Transcriptional regulator
I5I21_RS05835	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I5I21_RS05840	COG1845	cytochrome c oxidase, subunit III
I5I21_RS05845	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I5I21_RS05850	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I5I21_RS05855	COG2223	nitrite transmembrane transporter activity
I5I21_RS05860	COG3056	Lipoprotein
I5I21_RS05865	COG0271	Belongs to the BolA IbaG family
I5I21_RS05885	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I5I21_RS05890	COG0776	regulation of translation
I5I21_RS05895	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5I21_RS05900	COG1555	photosystem II stabilization
I5I21_RS05905	COG0824	Thioesterase
I5I21_RS05915	COG4533	DNA binding
I5I21_RS05930	COG1522	sequence-specific DNA binding
I5I21_RS05935	COG1132	(ABC) transporter
I5I21_RS05940	COG1132	(ABC) transporter
I5I21_RS05945	COG0347	Belongs to the P(II) protein family
I5I21_RS05950	COG0004	ammonium transporteR
I5I21_RS05955	COG1946	Acyl-CoA thioesterase
I5I21_RS05960	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I5I21_RS05965	COG3695	enzyme binding
I5I21_RS05995	COG2364	Membrane
I5I21_RS06010	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I5I21_RS06020	COG2182	Extracellular solute-binding protein
I5I21_RS06025	COG1175	transmembrane transport
I5I21_RS06030	COG3833	ABC-type maltose transport systems, permease component
I5I21_RS06035	COG3867	Arabinogalactan endo-beta-1,4-galactanase
I5I21_RS06040	COG1874	Beta-galactosidase
I5I21_RS06090	COG0110	maltose O-acetyltransferase activity
I5I21_RS06105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5I21_RS06110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5I21_RS06115	COG1309	transcriptional regulator
I5I21_RS06120	COG1196	nuclear chromosome segregation
I5I21_RS06120	COG3264	Mechanosensitive ion channel
I5I21_RS06125	COG5464	transposase or invertase
I5I21_RS06135	COG3923	Primosomal replication protein n
I5I21_RS06140	COG2832	Protein of unknown function (DUF454)
I5I21_RS06180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5I21_RS06185	COG4651	solute:proton antiporter activity
I5I21_RS06185	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I5I21_RS06190	COG2223	nitrite transmembrane transporter activity
I5I21_RS06200	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I5I21_RS06205	COG3735	TraB family
I5I21_RS06220	COG1585	Membrane protein implicated in regulation of membrane protease activity
I5I21_RS06225	COG0330	HflC and HflK could
I5I21_RS06230	COG4619	ABC transporter
I5I21_RS06235	COG0390	transport system, permease component
I5I21_RS06240	COG3118	belongs to the thioredoxin family
I5I21_RS06245	COG0300	oxidoreductase activity
I5I21_RS06250	COG2755	lipolytic protein G-D-S-L family
I5I21_RS06255	COG4181	ATPase activity
I5I21_RS06260	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I5I21_RS06280	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I5I21_RS06285	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I5I21_RS06300	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I5I21_RS06310	COG2501	S4 domain
I5I21_RS06360	COG3539	Fimbrial protein
I5I21_RS06365	COG3121	Chaperone
I5I21_RS06370	COG3188	usher protein
I5I21_RS06385	COG1560	Kdo2-lipid A biosynthetic process
I5I21_RS06395	COG3710	Transcriptional regulator
I5I21_RS06400	COG0531	amino acid
I5I21_RS06405	COG1982	Orn Lys Arg decarboxylase major
I5I21_RS06410	COG3104	oligopeptide transport
I5I21_RS06440	COG0673	inositol 2-dehydrogenase activity
I5I21_RS06455	COG1129	ABC transporter
I5I21_RS06460	COG4211	Belongs to the binding-protein-dependent transport system permease family
I5I21_RS06505	COG1566	PFAM secretion protein HlyD family protein
I5I21_RS06510	COG1120	ATPase activity
I5I21_RS06515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5I21_RS06545	COG1473	amidohydrolase
I5I21_RS06550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5I21_RS06555	COG0667	Aldo Keto reductase
I5I21_RS06600	COG0531	amino acid
I5I21_RS06610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5I21_RS06615	COG1012	belongs to the aldehyde dehydrogenase family
I5I21_RS06630	COG1113	amino acid transport
I5I21_RS06635	COG2211	Major facilitator Superfamily
I5I21_RS06645	COG0673	inositol 2-dehydrogenase activity
I5I21_RS06655	COG2771	luxR family
I5I21_RS06670	COG3188	usher protein
I5I21_RS06700	COG0668	transmembrane transport
I5I21_RS06705	COG0477	Major facilitator Superfamily
I5I21_RS06720	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I5I21_RS06720	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I5I21_RS06725	COG2222	sugar isomerase
I5I21_RS06730	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I5I21_RS06735	COG3716	PTS system mannose fructose sorbose family IID component
I5I21_RS06745	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5I21_RS06755	COG0778	Nitroreductase
I5I21_RS06760	COG2315	Protein conserved in bacteria
I5I21_RS06805	COG3698	Phosphodiester glycosidase
I5I21_RS06815	COG0697	spore germination
I5I21_RS06830	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I5I21_RS06835	COG0765	amino acid transport
I5I21_RS06840	COG4215	(ABC) transporter
I5I21_RS06850	COG4221	oxidoreductase activity
I5I21_RS06855	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I5I21_RS06860	COG4608	Belongs to the ABC transporter superfamily
I5I21_RS06865	COG0444	Belongs to the ABC transporter superfamily
I5I21_RS06870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5I21_RS06875	COG0601	transmembrane transport
I5I21_RS06880	COG0747	negative chemotaxis
I5I21_RS06905	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I5I21_RS06915	COG0668	transmembrane transport
I5I21_RS06920	COG0583	DNA-binding transcription factor activity
I5I21_RS06930	COG1028	Short-chain dehydrogenase reductase Sdr
I5I21_RS06940	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5I21_RS06945	COG1129	ABC transporter
I5I21_RS06955	COG1879	ABC-type sugar transport system periplasmic component
I5I21_RS06960	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I5I21_RS06965	COG2390	Transcriptional regulator
I5I21_RS06970	COG3959	Transketolase, thiamine diphosphate binding domain
I5I21_RS06975	COG3958	Transketolase
I5I21_RS06980	COG2977	Belongs to the P-Pant transferase superfamily
I5I21_RS06985	COG4771	TonB-dependent receptor
I5I21_RS06990	COG2382	esterase
I5I21_RS06995	COG3251	PFAM MbtH domain protein
I5I21_RS07000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I5I21_RS07000	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I5I21_RS07005	COG1120	ATPase activity
I5I21_RS07010	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5I21_RS07015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5I21_RS07025	COG4592	Periplasmic binding protein
I5I21_RS07030	COG1169	isochorismate synthase
I5I21_RS07035	COG1021	2,3-dihydroxybenzoate-AMP ligase
I5I21_RS07040	COG3433	isochorismatase activity
I5I21_RS07040	COG1535	isochorismatase
I5I21_RS07045	COG1028	Short-chain dehydrogenase reductase Sdr
I5I21_RS07055	COG1966	Carbon starvation protein
I5I21_RS07060	COG2879	small protein
I5I21_RS07075	COG1028	Short-chain dehydrogenase reductase Sdr
I5I21_RS07080	COG0371	Dehydrogenase
I5I21_RS07085	COG1129	ABC transporter
I5I21_RS07090	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5I21_RS07120	COG2271	Major facilitator Superfamily
I5I21_RS07125	COG0483	inositol monophosphate 1-phosphatase activity
I5I21_RS07135	COG0402	S-adenosylhomocysteine deaminase activity
I5I21_RS07145	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I5I21_RS07160	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5I21_RS07170	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5I21_RS07175	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5I21_RS07180	COG1129	ABC transporter
I5I21_RS07205	COG0436	Aminotransferase
I5I21_RS07210	COG1475	DNA binding
I5I21_RS07215	COG3969	phosphoadenosine phosphosulfate
I5I21_RS07220	COG0583	DNA-binding transcription factor activity
I5I21_RS07225	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I5I21_RS07245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I5I21_RS07250	COG3719	Belongs to the RNase T2 family
I5I21_RS07255	COG3069	C4-dicarboxylate transmembrane transporter activity
I5I21_RS07275	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I5I21_RS07290	COG0583	DNA-binding transcription factor activity
I5I21_RS07305	COG1686	Belongs to the peptidase S11 family
I5I21_RS07310	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I5I21_RS07315	COG0772	Belongs to the SEDS family
I5I21_RS07320	COG0768	penicillin binding
I5I21_RS07330	COG0799	negative regulation of ribosome biogenesis
I5I21_RS07345	COG1466	dna polymerase III delta subunit
I5I21_RS07360	COG2888	peptidyl-tyrosine sulfation
I5I21_RS07375	COG1126	abc transporter atp-binding protein
I5I21_RS07380	COG0765	amino acid transport
I5I21_RS07385	COG0765	amino acid transport
I5I21_RS07400	COG4535	Mg2 and Co2 transporter CorC
I5I21_RS07410	COG1702	phosphate starvation-inducible protein PhoH
I5I21_RS07420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5I21_RS07460	COG0367	asparagine synthase
I5I21_RS07465	COG0647	UMP catabolic process
I5I21_RS07470	COG1940	carbohydrate kinase activity
I5I21_RS07470	COG1846	Transcriptional regulator
I5I21_RS07475	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I5I21_RS07515	COG0735	belongs to the Fur family
I5I21_RS07530	COG0596	Alpha beta hydrolase
I5I21_RS07540	COG0033	Phosphoglucomutase
I5I21_RS07550	COG0745	RESPONSE REGULATOR receiver
I5I21_RS07555	COG2205	protein histidine kinase activity
I5I21_RS07585	COG0415	Belongs to the DNA photolyase family
I5I21_RS07600	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I5I21_RS07605	COG1984	allophanate hydrolase subunit 2
I5I21_RS07640	COG2009	succinate dehydrogenase
I5I21_RS07645	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I5I21_RS07650	COG1053	succinate dehydrogenase
I5I21_RS07655	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I5I21_RS07660	COG0567	Dehydrogenase, E1 component
I5I21_RS07665	COG0508	dehydrogenase complex catalyzes the overall conversion of
I5I21_RS07675	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I5I21_RS07680	COG1271	oxidase subunit
I5I21_RS07685	COG1294	oxidase, subunit
I5I21_RS07690	COG4890	Cyd operon protein YbgT
I5I21_RS07695	COG3790	cyd operon protein YbgE
I5I21_RS07700	COG0824	Thioesterase
I5I21_RS07705	COG0811	peptide transport
I5I21_RS07710	COG0848	biopolymer transport protein
I5I21_RS07715	COG3064	Membrane
I5I21_RS07725	COG2885	chlorophyll binding
I5I21_RS07730	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I5I21_RS07775	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I5I21_RS07780	COG3201	nicotinamide mononucleotide transporter
I5I21_RS07795	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I5I21_RS07805	COG2017	converts alpha-aldose to the beta-anomer
I5I21_RS07815	COG1085	galactose-1-phosphate uridylyltransferase
I5I21_RS07825	COG1119	ATPase activity
I5I21_RS07830	COG2005	Transcriptional regulator
I5I21_RS07830	COG3585	molybdate ion transport
I5I21_RS07840	COG0725	ABC transporter, periplasmic molybdate-binding protein
I5I21_RS07845	COG4149	molybdate abc transporter
I5I21_RS07850	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I5I21_RS07855	COG0561	phosphatase activity
I5I21_RS07880	COG2200	EAL domain
I5I21_RS07885	COG0789	Transcriptional regulator
I5I21_RS07920	COG4677	pectinesterase activity
I5I21_RS07960	COG1881	PFAM PEBP family protein
I5I21_RS07965	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I5I21_RS07980	COG2226	methyltransferase
I5I21_RS08005	COG0642	Histidine kinase
I5I21_RS08010	COG0745	RESPONSE REGULATOR receiver
I5I21_RS08030	COG0521	Mo-molybdopterin cofactor biosynthetic process
I5I21_RS08040	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I5I21_RS08045	COG0314	molybdopterin synthase activity
I5I21_RS08050	COG0670	Belongs to the BI1 family
I5I21_RS08055	COG0392	lysyltransferase activity
I5I21_RS08060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5I21_RS08065	COG3568	Endonuclease Exonuclease Phosphatase
I5I21_RS08075	COG0842	Transport permease protein
I5I21_RS08080	COG0842	Transport permease protein
I5I21_RS08085	COG1131	(ABC) transporter
I5I21_RS08090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5I21_RS08095	COG1309	transcriptional regulator
I5I21_RS08100	COG0583	DNA-binding transcription factor activity
I5I21_RS08110	COG2271	Major facilitator Superfamily
I5I21_RS08115	COG1028	Short-chain dehydrogenase reductase Sdr
I5I21_RS08120	COG3959	Transketolase, thiamine diphosphate binding domain
I5I21_RS08125	COG3958	Transketolase
I5I21_RS08130	COG0513	Belongs to the DEAD box helicase family
I5I21_RS08135	COG1199	ATP-dependent helicase activity
I5I21_RS08140	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I5I21_RS08150	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I5I21_RS08160	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I5I21_RS08170	COG0668	transmembrane transport
I5I21_RS08175	COG1126	abc transporter atp-binding protein
I5I21_RS08180	COG0765	amino acid transport
I5I21_RS08185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5I21_RS08200	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I5I21_RS08205	COG2194	sulfuric ester hydrolase activity
I5I21_RS08215	COG1321	iron dependent repressor
I5I21_RS08220	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I5I21_RS08225	COG2723	6-phospho-beta-galactosidase activity
I5I21_RS08230	COG2188	Transcriptional regulator
I5I21_RS08235	COG1376	ErfK ybiS ycfS ynhG family protein
I5I21_RS08240	COG2365	Tyrosine phosphatase family
I5I21_RS08245	COG0488	(ABC) transporter
I5I21_RS08255	COG2271	Major facilitator Superfamily
I5I21_RS08260	COG1609	Transcriptional regulator
I5I21_RS08270	COG0561	phosphatase activity
I5I21_RS08275	COG1882	Formate acetyltransferase
I5I21_RS08280	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I5I21_RS08285	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I5I21_RS08290	COG0303	'Molybdopterin
I5I21_RS08305	COG0747	negative chemotaxis
I5I21_RS08325	COG2223	nitrite transmembrane transporter activity
I5I21_RS08335	COG2133	pyrroloquinoline quinone binding
I5I21_RS08340	COG0625	glutathione transferase activity
I5I21_RS08350	COG1686	Belongs to the peptidase S11 family
I5I21_RS08355	COG1349	DNA-binding transcription factor activity
I5I21_RS08360	COG0671	phosphoesterase, PA-phosphatase related
I5I21_RS08365	COG2814	Major facilitator Superfamily
I5I21_RS08370	COG0561	phosphatase activity
I5I21_RS08375	COG0738	Major facilitator superfamily
I5I21_RS08380	COG3226	Transcriptional regulator
I5I21_RS08385	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I5I21_RS08390	COG3344	reverse transcriptase
I5I21_RS08415	COG4695	Portal protein
I5I21_RS08610	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I5I21_RS08615	COG3842	ATPase activity
I5I21_RS08620	COG1176	ABC-type spermidine putrescine transport system, permease component I
I5I21_RS08625	COG1177	transmembrane transport
I5I21_RS08640	COG0745	RESPONSE REGULATOR receiver
I5I21_RS08645	COG5002	protein histidine kinase activity
I5I21_RS08650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5I21_RS08655	COG4160	amino acid transport
I5I21_RS08660	COG4215	(ABC) transporter
I5I21_RS08665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5I21_RS08670	COG1126	abc transporter atp-binding protein
I5I21_RS08680	COG2203	Gaf domain
I5I21_RS08680	COG4251	negative regulation of phosphorylation
I5I21_RS08680	COG3706	GGDEF domain
I5I21_RS08680	COG5001	Diguanylate cyclase
I5I21_RS08685	COG3023	N-Acetylmuramoyl-L-alanine amidase
I5I21_RS08690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I5I21_RS08695	COG0702	epimerase
I5I21_RS08700	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I5I21_RS08705	COG0028	Belongs to the TPP enzyme family
I5I21_RS08715	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5I21_RS08725	COG2431	L-lysine efflux transmembrane transporter activity
I5I21_RS08735	COG3593	DNA synthesis involved in DNA repair
I5I21_RS08740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5I21_RS08750	COG1278	Cold shock
I5I21_RS08760	COG0542	response to heat
I5I21_RS08775	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I5I21_RS08780	COG4988	ABC transporter
I5I21_RS08785	COG0492	ferredoxin-NADP+ reductase activity
I5I21_RS08795	COG1178	ABC-type Fe3 transport system permease component
I5I21_RS08795	COG1674	ftsk spoiiie
I5I21_RS08805	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I5I21_RS08815	COG0243	molybdopterin cofactor binding
I5I21_RS08820	COG0437	4 iron, 4 sulfur cluster binding
I5I21_RS08825	COG3302	dmso reductase anchor subunit
I5I21_RS08830	COG0477	Major facilitator Superfamily
I5I21_RS08835	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I5I21_RS08840	COG1882	Formate acetyltransferase
I5I21_RS08845	COG2116	formate transmembrane transporter activity
I5I21_RS08850	COG1944	ATP diphosphatase activity
I5I21_RS08855	COG2323	membrane
I5I21_RS08875	COG0539	negative regulation of cytoplasmic translation
I5I21_RS08885	COG2333	competence protein COMEC
I5I21_RS08885	COG0658	competence protein
I5I21_RS08900	COG3214	Protein conserved in bacteria
I5I21_RS08915	COG3173	Aminoglycoside phosphotransferase
I5I21_RS08920	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I5I21_RS08925	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I5I21_RS08935	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I5I21_RS08945	COG2989	Protein conserved in bacteria
I5I21_RS08950	COG3108	Peptidase M15
I5I21_RS08955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5I21_RS08960	COG1448	Aminotransferase
I5I21_RS08985	COG0814	amino acid
I5I21_RS08995	COG1473	amidohydrolase
I5I21_RS09005	COG0308	aminopeptidase N
I5I21_RS09015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5I21_RS09020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5I21_RS09025	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5I21_RS09030	COG0431	NADPH-dependent FMN reductase
I5I21_RS09045	COG3217	Mosc domain protein beta barrel domain protein
I5I21_RS09045	COG0633	Ferredoxin
I5I21_RS09055	COG0488	(ABC) transporter
I5I21_RS09060	COG2995	paraquat-inducible protein a
I5I21_RS09065	COG3008	intermembrane lipid transfer
I5I21_RS09065	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I5I21_RS09070	COG3009	Protein conserved in bacteria
I5I21_RS09075	COG3130	regulation of translation
I5I21_RS09085	COG1067	ATP-dependent peptidase activity
I5I21_RS09105	COG3070	regulator of competence-specific genes
I5I21_RS09110	COG1289	transmembrane transporter activity
I5I21_RS09115	COG3304	Inner membrane component domain
I5I21_RS09120	COG0210	DNA helicase
I5I21_RS09130	COG1832	CoA-binding protein
I5I21_RS09145	COG1881	PFAM PEBP family protein
I5I21_RS09150	COG2207	Transcriptional regulator
I5I21_RS09165	COG0670	Belongs to the BI1 family
I5I21_RS09190	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5I21_RS09195	COG1012	belongs to the aldehyde dehydrogenase family
I5I21_RS09200	COG4638	Rieske (2fe-2S)
I5I21_RS09205	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I5I21_RS09210	COG0473	3-isopropylmalate dehydrogenase activity
I5I21_RS09215	COG0583	DNA-binding transcription factor activity
I5I21_RS09220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5I21_RS09225	COG1012	belongs to the aldehyde dehydrogenase family
I5I21_RS09230	COG1396	sequence-specific DNA binding
I5I21_RS09230	COG1917	Cupin 2, conserved barrel domain protein
I5I21_RS09235	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I5I21_RS09240	COG0174	glutamine synthetase
I5I21_RS09245	COG0531	amino acid
I5I21_RS09260	COG1028	Short-chain dehydrogenase reductase Sdr
I5I21_RS09290	COG3729	General stress protein
I5I21_RS09300	COG2233	PERMEase
I5I21_RS09335	COG1309	transcriptional regulator
I5I21_RS09350	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I5I21_RS09360	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I5I21_RS09380	COG1702	phosphate starvation-inducible protein PhoH
I5I21_RS09385	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I5I21_RS09395	COG1335	isochorismatase
I5I21_RS09405	COG0583	DNA-binding transcription factor activity
I5I21_RS09435	COG3381	protein complex oligomerization
I5I21_RS09470	COG5645	(Lipo)protein
I5I21_RS09485	COG1560	Kdo2-lipid A biosynthetic process
I5I21_RS09530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5I21_RS09550	COG2814	Major facilitator Superfamily
I5I21_RS09555	COG0583	DNA-binding transcription factor activity
I5I21_RS09560	COG1530	ribonuclease E activity
I5I21_RS09580	COG1399	metal-binding, possibly nucleic acid-binding protein
I5I21_RS09600	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I5I21_RS09615	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I5I21_RS09620	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I5I21_RS09625	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I5I21_RS09635	COG0470	DNA polymerase III
I5I21_RS09640	COG0084	hydrolase, TatD family'
I5I21_RS09650	COG0537	adenosine 5'-monophosphoramidase activity
I5I21_RS09655	COG5633	Lipoprotein
I5I21_RS09680	COG1252	NADH dehydrogenase
I5I21_RS09685	COG3134	Outer membrane lipoprotein
I5I21_RS09700	COG1309	transcriptional regulator
I5I21_RS09715	COG1376	ErfK ybiS ycfS ynhG family protein
I5I21_RS09715	COG1388	LysM domain
I5I21_RS09720	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I5I21_RS09730	COG4591	ABC-type transport system involved in lipoprotein release permease component
I5I21_RS09740	COG4591	ABC-type transport system involved in lipoprotein release permease component
I5I21_RS09750	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I5I21_RS09760	COG0318	PFAM AMP-dependent synthetase and ligase
I5I21_RS09775	COG1177	transmembrane transport
I5I21_RS09795	COG2850	peptidyl-arginine hydroxylation
I5I21_RS09800	COG2205	protein histidine kinase activity
I5I21_RS09820	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I5I21_RS09840	COG1187	pseudouridine synthase activity
I5I21_RS09845	COG0538	isocitrate dehydrogenase activity
I5I21_RS09850	COG0640	Transcriptional regulator
I5I21_RS09870	COG3813	Protein conserved in bacteria
I5I21_RS09875	COG1063	alcohol dehydrogenase
I5I21_RS09880	COG3729	General stress protein
I5I21_RS09885	COG3685	Protein conserved in bacteria
I5I21_RS09890	COG3685	Protein conserved in bacteria
I5I21_RS09895	COG3546	catalase activity
I5I21_RS09900	COG1271	oxidase subunit
I5I21_RS09905	COG1294	oxidase, subunit
I5I21_RS09935	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I5I21_RS09940	COG0583	DNA-binding transcription factor activity
I5I21_RS09945	COG3706	GGDEF domain
I5I21_RS09950	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I5I21_RS09960	COG1560	Kdo2-lipid A biosynthetic process
I5I21_RS09970	COG3182	Iron-regulated membrane protein
I5I21_RS09990	COG2203	Gaf domain
I5I21_RS09990	COG2199	diguanylate cyclase activity
I5I21_RS09995	COG3042	response to heat
I5I21_RS10000	COG3189	MarR family transcriptional regulator
I5I21_RS10005	COG1683	Conserved Protein
I5I21_RS10010	COG0504	CTP synthase activity
I5I21_RS10015	COG2807	transmembrane transport
I5I21_RS10020	COG2207	Transcriptional regulator
I5I21_RS10030	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I5I21_RS10035	COG0859	PFAM glycosyl transferase family 9
I5I21_RS10045	COG3344	reverse transcriptase
I5I21_RS10050	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I5I21_RS10055	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I5I21_RS10060	COG0583	DNA-binding transcription factor activity
I5I21_RS10065	COG1028	Short-chain dehydrogenase reductase Sdr
I5I21_RS10090	COG0386	Belongs to the glutathione peroxidase family
I5I21_RS10105	COG2766	serine protein kinase
I5I21_RS10110	COG3713	MltA-interacting MipA family protein
I5I21_RS10115	COG0656	L-ascorbic acid biosynthetic process
I5I21_RS10135	COG3139	Protein of unknown function (DUF1315)
I5I21_RS10150	COG1063	alcohol dehydrogenase
I5I21_RS10155	COG2271	Major facilitator Superfamily
I5I21_RS10160	COG1063	alcohol dehydrogenase
I5I21_RS10165	COG0191	fructose-bisphosphate aldolase activity
I5I21_RS10170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5I21_RS10175	COG0667	Aldo Keto reductase
I5I21_RS10180	COG1349	DNA-binding transcription factor activity
I5I21_RS10185	COG2814	Major facilitator Superfamily
I5I21_RS10190	COG1335	isochorismatase
I5I21_RS10195	COG0252	asparaginase activity
I5I21_RS10200	COG0616	signal peptide processing
I5I21_RS10205	COG0778	Nitroreductase
I5I21_RS10220	COG0709	Synthesizes selenophosphate from selenide and ATP
I5I21_RS10225	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I5I21_RS10230	COG3321	synthase
I5I21_RS10230	COG0604	alcohol dehydrogenase
I5I21_RS10230	COG1028	Short-chain dehydrogenase reductase Sdr
I5I21_RS10235	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I5I21_RS10240	COG0494	nUDIX hydrolase
I5I21_RS10245	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I5I21_RS10250	COG2897	thiosulfate sulfurtransferase activity
I5I21_RS10255	COG4136	ATPase activity
I5I21_RS10260	COG4135	transport system, permease component
I5I21_RS10265	COG4134	Bacterial extracellular solute-binding protein
I5I21_RS10270	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5I21_RS10275	COG0398	Pfam SNARE associated Golgi protein
I5I21_RS10280	COG0398	Pfam SNARE associated Golgi protein
I5I21_RS10285	COG0708	Exodeoxyribonuclease III
I5I21_RS10295	COG3138	arginine N-succinyltransferase
I5I21_RS10305	COG3724	N-succinylarginine dihydrolase activity
I5I21_RS10315	COG3678	ATP-independent chaperone mediated protein folding
I5I21_RS10320	COG0322	excinuclease ABC activity
I5I21_RS10330	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I5I21_RS10335	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5I21_RS10345	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5I21_RS10350	COG1447	Phosphotransferase system cellobiose-specific component IIA
I5I21_RS10355	COG1917	Cupin 2, conserved barrel domain protein
I5I21_RS10355	COG2169	Transcriptional regulator
I5I21_RS10360	COG1486	melibiose metabolic process
I5I21_RS10370	COG0753	catalase activity
I5I21_RS10380	COG1823	symporter activity
I5I21_RS10385	COG1988	membrane-bound metal-dependent
I5I21_RS10390	COG1028	Short-chain dehydrogenase reductase Sdr
I5I21_RS10395	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5I21_RS10425	COG0727	PFAM Uncharacterised protein family (UPF0153)
I5I21_RS10430	COG3047	cAMP biosynthetic process
I5I21_RS10440	COG4774	siderophore transport
I5I21_RS10495	COG0135	phosphoribosylanthranilate isomerase activity
I5I21_RS10495	COG0134	indole-3-glycerol-phosphate synthase activity
I5I21_RS10500	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I5I21_RS10500	COG0512	Glutamine amidotransferase of anthranilate synthase
I5I21_RS10505	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I5I21_RS10515	COG0009	L-threonylcarbamoyladenylate synthase
I5I21_RS10525	COG0583	DNA-binding transcription factor activity
I5I21_RS10535	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I5I21_RS10540	COG1028	Short-chain dehydrogenase reductase Sdr
I5I21_RS10550	COG0616	signal peptide processing
I5I21_RS10575	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I5I21_RS10585	COG0671	phosphoesterase, PA-phosphatase related
I5I21_RS10590	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I5I21_RS10595	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I5I21_RS10605	COG0023	Translation Initiation Factor
I5I21_RS10615	COG1349	DNA-binding transcription factor activity
I5I21_RS10630	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5I21_RS10630	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5I21_RS10635	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I5I21_RS10645	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I5I21_RS10660	COG4171	peptide transport system, permease
I5I21_RS10775	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I5I21_RS10825	COG5484	DNA packaging
I5I21_RS10825	COG3728	DNA packaging
I5I21_RS10920	COG1196	nuclear chromosome segregation
I5I21_RS11040	COG3344	reverse transcriptase
I5I21_RS11045	COG3344	reverse transcriptase
I5I21_RS11050	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I5I21_RS11055	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I5I21_RS11065	COG2135	peptidase activity
I5I21_RS11080	COG0702	epimerase
I5I21_RS11095	COG1473	amidohydrolase
I5I21_RS11105	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I5I21_RS11110	COG1842	Phage shock protein A
I5I21_RS11120	COG1983	PspC domain protein
I5I21_RS11130	COG3106	COG3106 Predicted ATPase
I5I21_RS11140	COG0583	DNA-binding transcription factor activity
I5I21_RS11145	COG1486	melibiose metabolic process
I5I21_RS11155	COG3180	Ammonia monooxygenase
I5I21_RS11160	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I5I21_RS11165	COG4948	Mandelate Racemase Muconate Lactonizing
I5I21_RS11170	COG2866	Carboxypeptidase
I5I21_RS11180	COG4166	transmembrane transport
I5I21_RS11210	COG0656	L-ascorbic acid biosynthetic process
I5I21_RS11225	COG0583	DNA-binding transcription factor activity
I5I21_RS11230	COG1028	Short-chain dehydrogenase reductase Sdr
I5I21_RS11235	COG1078	dGTPase activity
I5I21_RS11240	COG0693	protein deglycase activity
I5I21_RS11245	COG0582	viral genome integration into host DNA
I5I21_RS11350	COG0484	heat shock protein binding
I5I21_RS11360	COG3772	lysozyme
I5I21_RS11380	COG1783	phage Terminase large subunit
I5I21_RS11385	COG3567	Phage-associated protein, HI1409 family
I5I21_RS11455	COG0741	lytic transglycosylase activity
I5I21_RS11455	COG0739	heme binding
I5I21_RS11455	COG1196	nuclear chromosome segregation
I5I21_RS11540	COG3344	reverse transcriptase
I5I21_RS11575	COG2885	chlorophyll binding
I5I21_RS11670	COG1028	Short-chain dehydrogenase reductase Sdr
I5I21_RS11675	COG1309	transcriptional regulator
I5I21_RS11680	COG1028	Short-chain dehydrogenase reductase Sdr
I5I21_RS11700	COG0583	DNA-binding transcription factor activity
I5I21_RS11730	COG0604	alcohol dehydrogenase
I5I21_RS11735	COG0436	Aminotransferase
I5I21_RS11750	COG2011	ABC-type metal ion transport system permease component
I5I21_RS11755	COG1448	Aminotransferase
I5I21_RS11765	COG1522	sequence-specific DNA binding
I5I21_RS11770	COG1113	amino acid transport
I5I21_RS11785	COG0673	inositol 2-dehydrogenase activity
I5I21_RS11790	COG1349	DNA-binding transcription factor activity
I5I21_RS11800	COG0513	Belongs to the DEAD box helicase family
I5I21_RS11810	COG0589	response to stress
I5I21_RS11820	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I5I21_RS11825	COG0674	pyruvate-flavodoxin oxidoreductase activity
I5I21_RS11825	COG1013	pyruvate-flavodoxin oxidoreductase activity
I5I21_RS11825	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I5I21_RS11825	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I5I21_RS11830	COG3042	response to heat
I5I21_RS11835	COG3187	Heat shock protein
I5I21_RS11840	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I5I21_RS11845	COG0586	Pfam SNARE associated Golgi protein
I5I21_RS11850	COG2911	Protein conserved in bacteria
I5I21_RS11860	COG3784	Protein of unknown function (DUF1318)
I5I21_RS11865	COG2207	Transcriptional regulator
I5I21_RS11870	COG1012	belongs to the aldehyde dehydrogenase family
I5I21_RS11890	COG2030	dehydratase
I5I21_RS11890	COG1012	belongs to the aldehyde dehydrogenase family
I5I21_RS11895	COG3396	Phenylacetate-CoA oxygenase
I5I21_RS11900	COG3460	Phenylacetate-CoA oxygenase
I5I21_RS11905	COG3396	Phenylacetate-CoA oxygenase
I5I21_RS11910	COG2151	metal-sulfur cluster biosynthetic enzyme
I5I21_RS11915	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5I21_RS11920	COG1024	Enoyl-CoA hydratase
I5I21_RS11925	COG1024	Enoyl-CoA hydratase
I5I21_RS11930	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5I21_RS11935	COG2050	protein possibly involved in aromatic compounds catabolism
I5I21_RS11940	COG0183	Belongs to the thiolase family
I5I21_RS11945	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I5I21_RS11950	COG3327	negative regulation of DNA-templated transcription, initiation
I5I21_RS11955	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I5I21_RS11970	COG1643	Atp-dependent helicase
I5I21_RS11975	COG4122	O-methyltransferase activity
I5I21_RS12000	COG0583	DNA-binding transcription factor activity
I5I21_RS12005	COG0667	Aldo Keto reductase
I5I21_RS12010	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I5I21_RS12020	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I5I21_RS12025	COG3138	arginine N-succinyltransferase
I5I21_RS12030	COG1012	belongs to the aldehyde dehydrogenase family
I5I21_RS12035	COG3724	N-succinylarginine dihydrolase activity
I5I21_RS12040	COG2988	succinylglutamate desuccinylase activity
I5I21_RS12045	COG1113	amino acid transport
I5I21_RS12050	COG0477	Major facilitator Superfamily
I5I21_RS12055	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I5I21_RS12065	COG1012	belongs to the aldehyde dehydrogenase family
I5I21_RS12070	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I5I21_RS12075	COG0401	homolog of Blt101
I5I21_RS12080	COG5562	phage envelope protein
I5I21_RS12085	COG0425	Belongs to the sulfur carrier protein TusA family
I5I21_RS12090	COG2391	methyltransferase activity
I5I21_RS12115	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I5I21_RS12120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5I21_RS12120	COG1263	PTS System
I5I21_RS12125	COG1609	Transcriptional regulator
I5I21_RS12130	COG5339	Protein conserved in bacteria
I5I21_RS12135	COG1482	cell wall glycoprotein biosynthetic process
I5I21_RS12140	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I5I21_RS12140	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I5I21_RS12145	COG0114	fumarate hydratase activity
I5I21_RS12155	COG2205	protein histidine kinase activity
I5I21_RS12165	COG0745	RESPONSE REGULATOR receiver
I5I21_RS12170	COG3136	membrane protein required for alginate biosynthesis
I5I21_RS12180	COG0531	amino acid
I5I21_RS12195	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I5I21_RS12200	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I5I21_RS12215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5I21_RS12230	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I5I21_RS12235	COG1473	amidohydrolase
I5I21_RS12245	COG0583	DNA-binding transcription factor activity
I5I21_RS12250	COG2840	Smr protein MutS2
I5I21_RS12255	COG1414	Transcriptional regulator
I5I21_RS12265	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I5I21_RS12270	COG0183	Belongs to the thiolase family
I5I21_RS12280	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I5I21_RS12285	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5I21_RS12295	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I5I21_RS12295	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I5I21_RS12315	COG4565	transcriptional regulatory protein
I5I21_RS12320	COG3290	protein histidine kinase activity
I5I21_RS12345	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I5I21_RS12355	COG0679	Auxin Efflux Carrier
I5I21_RS12385	COG0628	permease
I5I21_RS12405	COG3591	Belongs to the peptidase S1B family
I5I21_RS12415	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I5I21_RS12420	COG2814	Major facilitator Superfamily
I5I21_RS12425	COG0583	DNA-binding transcription factor activity
I5I21_RS12430	COG1940	carbohydrate kinase activity
I5I21_RS12435	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I5I21_RS12450	COG3302	dmso reductase anchor subunit
I5I21_RS12455	COG0437	4 iron, 4 sulfur cluster binding
I5I21_RS12460	COG0243	molybdopterin cofactor binding
I5I21_RS12475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5I21_RS12490	COG2271	Major facilitator Superfamily
I5I21_RS12495	COG0246	Mannitol dehydrogenase
I5I21_RS12500	COG0589	response to stress
I5I21_RS12505	COG1802	Transcriptional regulator
I5I21_RS12510	COG4221	oxidoreductase activity
I5I21_RS12525	COG2207	Transcriptional regulator
I5I21_RS12530	COG2135	peptidase activity
I5I21_RS12545	COG2197	response regulator
I5I21_RS12560	COG0071	Belongs to the small heat shock protein (HSP20) family
I5I21_RS12565	COG1546	Belongs to the CinA family
I5I21_RS12570	COG2200	EAL domain
I5I21_RS12585	COG2207	Transcriptional regulator
I5I21_RS12585	COG3708	Transcriptional regulator
I5I21_RS12590	COG2610	gluconate transmembrane transporter activity
I5I21_RS12595	COG3622	Belongs to the hyi family
I5I21_RS12600	COG0235	Class ii aldolase
I5I21_RS12605	COG3395	kinase activity
I5I21_RS12610	COG2084	Dehydrogenase
I5I21_RS12615	COG1349	DNA-binding transcription factor activity
I5I21_RS12630	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I5I21_RS12635	COG2223	nitrite transmembrane transporter activity
I5I21_RS12670	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I5I21_RS12675	COG0683	leucine binding
I5I21_RS12690	COG1129	ABC transporter
I5I21_RS12695	COG0410	ABC transporter
I5I21_RS12705	COG2814	Major facilitator Superfamily
I5I21_RS12710	COG0697	spore germination
I5I21_RS12720	COG4977	sequence-specific DNA binding
I5I21_RS12750	COG1028	Short-chain dehydrogenase reductase Sdr
I5I21_RS12755	COG2731	YhcH YjgK YiaL family protein
I5I21_RS12770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I5I21_RS12780	COG3395	kinase activity
I5I21_RS12785	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I5I21_RS12790	COG1349	DNA-binding transcription factor activity
I5I21_RS12795	COG0039	L-malate dehydrogenase activity
I5I21_RS12805	COG0583	DNA-binding transcription factor activity
I5I21_RS12810	COG1012	belongs to the aldehyde dehydrogenase family
I5I21_RS12825	COG2199	diguanylate cyclase activity
I5I21_RS12895	COG0477	Major facilitator Superfamily
I5I21_RS12905	COG2070	2-Nitropropane dioxygenase
I5I21_RS12910	COG2011	ABC-type metal ion transport system permease component
I5I21_RS12930	COG4628	conserved protein (DUF2132)
I5I21_RS12945	COG2207	Transcriptional regulator
I5I21_RS12975	COG2233	PERMEase
I5I21_RS12980	COG3648	Uricase
I5I21_RS12980	COG3195	allantoin biosynthetic process
I5I21_RS12985	COG2351	hydroxyisourate hydrolase activity
I5I21_RS12990	COG1396	sequence-specific DNA binding
I5I21_RS12995	COG3550	peptidyl-serine autophosphorylation
I5I21_RS13000	COG1649	PFAM Uncharacterised BCR, COG1649
I5I21_RS13010	COG3188	usher protein
I5I21_RS13045	COG3300	MHYT domain
I5I21_RS13045	COG5001	Diguanylate cyclase
I5I21_RS13050	COG2819	hydrolase of the alpha beta superfamily
I5I21_RS13065	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5I21_RS13065	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5I21_RS13070	COG2814	Major facilitator Superfamily
I5I21_RS13080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5I21_RS13080	COG1263	PTS System
I5I21_RS13085	COG2186	Transcriptional regulator
I5I21_RS13105	COG3835	regulator
I5I21_RS13110	COG1929	Belongs to the glycerate kinase type-1 family
I5I21_RS13155	COG0738	Major facilitator superfamily
I5I21_RS13160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5I21_RS13165	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I5I21_RS13170	COG1349	DNA-binding transcription factor activity
I5I21_RS13185	COG1349	DNA-binding transcription factor activity
I5I21_RS13190	COG4977	sequence-specific DNA binding
I5I21_RS13210	COG4977	sequence-specific DNA binding
I5I21_RS13230	COG0667	Aldo Keto reductase
I5I21_RS13240	COG0667	Aldo Keto reductase
I5I21_RS13245	COG0667	Aldo Keto reductase
I5I21_RS13255	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I5I21_RS13255	COG0456	acetyltransferase
I5I21_RS13280	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I5I21_RS13280	COG0426	domain, Protein
I5I21_RS13295	COG1652	LysM domain
I5I21_RS13325	COG1609	Transcriptional regulator
I5I21_RS13335	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5I21_RS13350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I5I21_RS13360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5I21_RS13365	COG0583	DNA-binding transcription factor activity
I5I21_RS13370	COG0583	DNA-binding transcription factor activity
I5I21_RS13385	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I5I21_RS13385	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5I21_RS13385	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5I21_RS13390	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5I21_RS13400	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I5I21_RS13405	COG3037	sugar-specific permease SgaT UlaA
I5I21_RS13415	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5I21_RS13420	COG1609	Transcriptional regulator
I5I21_RS13430	COG2223	nitrite transmembrane transporter activity
I5I21_RS13460	COG0477	Major facilitator Superfamily
I5I21_RS13465	COG4529	Protein conserved in bacteria
I5I21_RS13470	COG1902	pentaerythritol trinitrate reductase activity
I5I21_RS13480	COG0583	DNA-binding transcription factor activity
I5I21_RS13485	COG2070	2-Nitropropane dioxygenase
I5I21_RS13495	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I5I21_RS13505	COG0765	amino acid transport
I5I21_RS13575	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I5I21_RS13605	COG1335	isochorismatase
I5I21_RS13610	COG0406	alpha-ribazole phosphatase activity
I5I21_RS13645	COG1953	Uracil, thiamine, allantoin
I5I21_RS13650	COG0402	S-adenosylhomocysteine deaminase activity
I5I21_RS13655	COG3706	GGDEF domain
I5I21_RS13660	COG1609	Transcriptional regulator
I5I21_RS13670	COG0673	inositol 2-dehydrogenase activity
I5I21_RS13685	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I5I21_RS13690	COG1116	anion transmembrane transporter activity
I5I21_RS13695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5I21_RS13700	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5I21_RS13705	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I5I21_RS13710	COG0076	glutamate decarboxylase activity
I5I21_RS13725	COG2205	protein histidine kinase activity
I5I21_RS13735	COG0596	Alpha beta hydrolase
I5I21_RS13775	COG0519	Catalyzes the synthesis of GMP from XMP
I5I21_RS13775	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I5I21_RS13795	COG0583	DNA-binding transcription factor activity
I5I21_RS13805	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I5I21_RS13810	COG1285	pathogenesis
I5I21_RS13815	COG2814	Major facilitator Superfamily
I5I21_RS13820	COG1447	Phosphotransferase system cellobiose-specific component IIA
I5I21_RS13825	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5I21_RS13850	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5I21_RS13855	COG0583	DNA-binding transcription factor activity
I5I21_RS13860	COG0243	molybdopterin cofactor binding
I5I21_RS13865	COG3781	membrane
I5I21_RS13890	COG1764	response to oxidative stress
I5I21_RS13900	COG3111	PFAM Bacterial OB fold (BOF) protein
I5I21_RS13910	COG2323	membrane
I5I21_RS13920	COG0366	Alpha amylase catalytic
I5I21_RS13930	COG3685	Protein conserved in bacteria
I5I21_RS13940	COG3729	General stress protein
I5I21_RS13945	COG1028	Short-chain dehydrogenase reductase Sdr
I5I21_RS13990	COG0488	(ABC) transporter
I5I21_RS14005	COG1064	alcohol dehydrogenase
I5I21_RS14010	COG0747	negative chemotaxis
I5I21_RS14020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5I21_RS14030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5I21_RS14040	COG2814	Major facilitator Superfamily
I5I21_RS14050	COG2326	polyphosphate kinase activity
I5I21_RS14065	COG2864	formate dehydrogenase
I5I21_RS14070	COG0437	4 iron, 4 sulfur cluster binding
I5I21_RS14095	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I5I21_RS14105	COG3485	protocatechuate 3,4-dioxygenase
I5I21_RS14110	COG4829	muconolactone delta-isomerase
I5I21_RS14115	COG4948	Mandelate Racemase Muconate Lactonizing
I5I21_RS14120	COG1414	Transcriptional regulator
I5I21_RS14140	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I5I21_RS14145	COG1140	nitrate reductase beta subunit
I5I21_RS14150	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I5I21_RS14155	COG2181	nitrate reductase activity
I5I21_RS14160	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I5I21_RS14165	COG1178	ABC-type Fe3 transport system permease component
I5I21_RS14170	COG1840	ABC-type Fe3 transport system, periplasmic component
I5I21_RS14175	COG3842	ATPase activity
I5I21_RS14180	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I5I21_RS14215	COG0625	glutathione transferase activity
I5I21_RS14225	COG1126	abc transporter atp-binding protein
I5I21_RS14230	COG0765	amino acid transport
I5I21_RS14240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5I21_RS14245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5I21_RS14250	COG1473	amidohydrolase
I5I21_RS14255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5I21_RS14260	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I5I21_RS14285	COG4772	TonB-dependent receptor
I5I21_RS14290	COG1228	amidohydrolase
I5I21_RS14295	COG3691	Protein conserved in bacteria
I5I21_RS14310	COG2130	NADP-dependent
I5I21_RS14320	COG1247	-acetyltransferase
I5I21_RS14325	COG3238	Protein conserved in bacteria
I5I21_RS14335	COG0747	negative chemotaxis
I5I21_RS14340	COG1012	belongs to the aldehyde dehydrogenase family
I5I21_RS14375	COG1012	belongs to the aldehyde dehydrogenase family
I5I21_RS14380	COG1177	transmembrane transport
I5I21_RS14385	COG1176	ABC-type spermidine putrescine transport system, permease component I
I5I21_RS14390	COG3842	ATPase activity
I5I21_RS14395	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I5I21_RS14400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5I21_RS14405	COG1271	oxidase subunit
I5I21_RS14410	COG1294	oxidase, subunit
I5I21_RS14430	COG0826	peptidase U32
I5I21_RS14440	COG1396	sequence-specific DNA binding
I5I21_RS14445	COG3135	benzoate transporter
I5I21_RS14450	COG2207	Transcriptional regulator
I5I21_RS14450	COG3708	Transcriptional regulator
I5I21_RS14465	COG0500	methyltransferase
I5I21_RS14470	COG1275	C4-dicarboxylate transporter malic acid transport protein
I5I21_RS14475	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I5I21_RS14480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5I21_RS14495	COG2272	Belongs to the type-B carboxylesterase lipase family
I5I21_RS14500	COG5383	Protein conserved in bacteria
I5I21_RS14505	COG3485	protocatechuate 3,4-dioxygenase
I5I21_RS14510	COG3485	protocatechuate 3,4-dioxygenase
I5I21_RS14515	COG0583	DNA-binding transcription factor activity
I5I21_RS14535	COG3038	cytochrome b561
I5I21_RS14555	COG2814	Major facilitator Superfamily
I5I21_RS14565	COG0673	inositol 2-dehydrogenase activity
I5I21_RS14575	COG2723	6-phospho-beta-galactosidase activity
I5I21_RS14610	COG4659	FMN binding
I5I21_RS14620	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I5I21_RS14630	COG0625	glutathione transferase activity
I5I21_RS14635	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I5I21_RS14650	COG3895	Periplasmic Protein
I5I21_RS14665	COG3706	GGDEF domain
I5I21_RS14680	COG1566	PFAM secretion protein HlyD family protein
I5I21_RS14685	COG1289	transmembrane transporter activity
I5I21_RS14690	COG2032	superoxide dismutase activity
I5I21_RS14695	COG4989	oxidoreductase activity
I5I21_RS14700	COG3313	Fe-S protein
I5I21_RS14705	COG1309	transcriptional regulator
I5I21_RS14710	COG1902	pentaerythritol trinitrate reductase activity
I5I21_RS14715	COG0346	lactoylglutathione lyase activity
I5I21_RS14725	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I5I21_RS14730	COG0791	NLP P60 protein
I5I21_RS14745	COG2814	Major facilitator Superfamily
I5I21_RS14760	COG0583	DNA-binding transcription factor activity
I5I21_RS14765	COG2814	Major facilitator Superfamily
I5I21_RS14770	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I5I21_RS14775	COG0307	riboflavin synthase, alpha
I5I21_RS14860	COG1349	DNA-binding transcription factor activity
I5I21_RS14865	COG0346	lactoylglutathione lyase activity
I5I21_RS14890	COG0444	Belongs to the ABC transporter superfamily
I5I21_RS14895	COG4608	Belongs to the ABC transporter superfamily
I5I21_RS14925	COG0604	alcohol dehydrogenase
I5I21_RS14925	COG1028	Short-chain dehydrogenase reductase Sdr
I5I21_RS14925	COG3321	synthase
I5I21_RS14965	COG0402	S-adenosylhomocysteine deaminase activity
I5I21_RS14990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5I21_RS14995	COG0277	FAD linked oxidase domain protein
I5I21_RS15020	COG0583	DNA-binding transcription factor activity
I5I21_RS15030	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I5I21_RS15040	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5I21_RS15045	COG2610	gluconate transmembrane transporter activity
I5I21_RS15050	COG1028	Short-chain dehydrogenase reductase Sdr
I5I21_RS15085	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5I21_RS15100	COG0745	RESPONSE REGULATOR receiver
I5I21_RS15105	COG5002	protein histidine kinase activity
I5I21_RS15105	COG3850	Histidine kinase
I5I21_RS15120	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I5I21_RS15140	COG3088	subunit of a heme lyase
I5I21_RS15140	COG4235	cytochrome complex assembly
I5I21_RS15145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5I21_RS15150	COG1138	Cytochrome C-type biogenesis protein
I5I21_RS15165	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I5I21_RS15170	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I5I21_RS15175	COG4133	protoheme IX ABC transporter activity
I5I21_RS15205	COG1175	transmembrane transport
I5I21_RS15215	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I5I21_RS15220	COG3383	formate dehydrogenase (NAD+) activity
I5I21_RS15260	COG1126	abc transporter atp-binding protein
I5I21_RS15265	COG0765	amino acid transport
I5I21_RS15285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5I21_RS15290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5I21_RS15295	COG1120	ATPase activity
I5I21_RS15300	COG4774	siderophore transport
I5I21_RS15305	COG1116	anion transmembrane transporter activity
I5I21_RS15310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5I21_RS15330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5I21_RS15335	COG0583	DNA-binding transcription factor activity
I5I21_RS15355	COG2814	Major facilitator Superfamily
I5I21_RS15390	COG1414	Transcriptional regulator
I5I21_RS15395	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I5I21_RS15400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5I21_RS15405	COG1120	ATPase activity
I5I21_RS15415	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I5I21_RS15420	COG2271	Major facilitator Superfamily
I5I21_RS15425	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I5I21_RS15425	COG1082	Xylose isomerase domain protein TIM barrel
I5I21_RS15430	COG1309	transcriptional regulator
I5I21_RS15460	COG1376	ErfK ybiS ycfS ynhG family protein
I5I21_RS15475	COG0719	Fe-S assembly protein
I5I21_RS15480	COG0396	ATPase activity
I5I21_RS15485	COG0719	Fe-S assembly protein
I5I21_RS15490	COG0316	Belongs to the HesB IscA family
I5I21_RS15510	COG1309	transcriptional regulator
I5I21_RS15515	COG1304	FMN binding
I5I21_RS15540	COG0583	DNA-binding transcription factor activity
I5I21_RS15550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5I21_RS15555	COG1120	ATPase activity
I5I21_RS15580	COG2261	transglycosylase associated protein
I5I21_RS15585	COG2050	protein possibly involved in aromatic compounds catabolism
I5I21_RS15590	COG0277	FAD linked oxidase domain protein
I5I21_RS15590	COG0247	lactate metabolic process
I5I21_RS15595	COG0628	permease
I5I21_RS15605	COG0574	Belongs to the PEP-utilizing enzyme family
I5I21_RS15605	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I5I21_RS15620	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I5I21_RS15625	COG4256	Hemin uptake protein
I5I21_RS15635	COG0791	NLP P60 protein
I5I21_RS15645	COG0386	Belongs to the glutathione peroxidase family
I5I21_RS15665	COG0583	DNA-binding transcription factor activity
I5I21_RS15685	COG0072	phenylalanine-tRNA ligase activity
I5I21_RS15685	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I5I21_RS15725	COG3137	Salt-induced outer membrane protein
I5I21_RS15730	COG1105	Belongs to the carbohydrate kinase PfkB family
I5I21_RS15740	COG3001	Fructosamine kinase
I5I21_RS15750	COG2350	Protein conserved in bacteria
I5I21_RS15760	COG2353	YceI-like domain
I5I21_RS15780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5I21_RS15790	COG0444	Belongs to the ABC transporter superfamily
I5I21_RS15795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5I21_RS15800	COG0601	transmembrane transport
I5I21_RS15805	COG4166	transmembrane transport
I5I21_RS15810	COG2095	MarC family integral membrane protein
I5I21_RS15820	COG1454	alcohol dehydrogenase
I5I21_RS15820	COG1012	belongs to the aldehyde dehydrogenase family
I5I21_RS15825	COG1435	thymidine kinase activity
I5I21_RS15835	COG2916	Histone family protein nucleoid-structuring protein H-NS
I5I21_RS15840	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I5I21_RS15845	COG0745	RESPONSE REGULATOR receiver
I5I21_RS15850	COG1752	Esterase of the alpha-beta hydrolase superfamily
I5I21_RS15860	COG0788	formyltetrahydrofolate deformylase activity
I5I21_RS15895	COG1522	sequence-specific DNA binding
I5I21_RS15905	COG2181	nitrate reductase activity
I5I21_RS15910	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I5I21_RS15915	COG1140	nitrate reductase beta subunit
I5I21_RS15920	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I5I21_RS15930	COG2223	nitrite transmembrane transporter activity
I5I21_RS15935	COG3850	Histidine kinase
I5I21_RS15940	COG2197	response regulator
I5I21_RS15945	COG4932	domain protein
I5I21_RS15950	COG0243	molybdopterin cofactor binding
I5I21_RS15955	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I5I21_RS15955	COG2146	nitrite reductase [NAD(P)H] activity
I5I21_RS15960	COG1116	anion transmembrane transporter activity
I5I21_RS15970	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5I21_RS15975	COG3707	response regulator
I5I21_RS15980	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I5I21_RS15990	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I5I21_RS15995	COG4572	Cation transport regulator
I5I21_RS16000	COG0387	Pfam Sodium calcium exchanger
I5I21_RS16020	COG2890	protein-(glutamine-N5) methyltransferase activity
I5I21_RS16050	COG0659	secondary active sulfate transmembrane transporter activity
I5I21_RS16070	COG0012	GTP binding
I5I21_RS16165	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I5I21_RS16220	COG2885	chlorophyll binding
I5I21_RS16240	COG3122	Protein conserved in bacteria
I5I21_RS16255	COG0583	DNA-binding transcription factor activity
I5I21_RS16285	COG0583	DNA-binding transcription factor activity
I5I21_RS16320	COG1882	Formate acetyltransferase
I5I21_RS16335	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I5I21_RS16340	COG0583	DNA-binding transcription factor activity
I5I21_RS16385	COG2308	Evidence 4 Homologs of previously reported genes of
I5I21_RS16400	COG4774	siderophore transport
I5I21_RS16410	COG1619	proteins homologs of microcin C7 resistance protein MccF
I5I21_RS16435	COG2719	SpoVR family
I5I21_RS16465	COG0179	Fumarylacetoacetate (FAA) hydrolase
I5I21_RS16480	COG2894	cell division
I5I21_RS16490	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I5I21_RS16500	COG3065	identical protein binding
I5I21_RS16510	COG1199	ATP-dependent helicase activity
I5I21_RS16515	COG0251	oxidation-reduction process
I5I21_RS16535	COG1760	l-serine dehydratase
I5I21_RS16540	COG2200	EAL domain
I5I21_RS16545	COG1253	flavin adenine dinucleotide binding
I5I21_RS16550	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5I21_RS16550	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5I21_RS16555	COG3715	PTS system
I5I21_RS16560	COG3716	PTS system mannose fructose sorbose family IID component
I5I21_RS16575	COG2226	methyltransferase
I5I21_RS16580	COG0768	penicillin binding
I5I21_RS16610	COG1414	Transcriptional regulator
I5I21_RS16615	COG2814	Major facilitator Superfamily
I5I21_RS16635	COG1956	GAF domain-containing protein
I5I21_RS16640	COG2995	paraquat-inducible protein a
I5I21_RS16645	COG3008	intermembrane lipid transfer
I5I21_RS16670	COG2990	Protein conserved in bacteria
I5I21_RS16685	COG1276	copper resistance
I5I21_RS16690	COG2372	response to copper ion
I5I21_RS16700	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I5I21_RS16705	COG1770	oligopeptidase
I5I21_RS16710	COG2979	Protein of unknown function (DUF533)
I5I21_RS16715	COG3141	response to X-ray
I5I21_RS16725	COG0800	Aldolase
I5I21_RS16730	COG0129	dihydroxy-acid dehydratase activity
I5I21_RS16735	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I5I21_RS16745	COG1737	Transcriptional regulator
I5I21_RS16755	COG1560	Kdo2-lipid A biosynthetic process
I5I21_RS16760	COG0739	heme binding
I5I21_RS16765	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I5I21_RS16775	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5I21_RS16800	COG0494	nUDIX hydrolase
I5I21_RS16810	COG1335	isochorismatase
I5I21_RS16815	COG1801	Protein of unknown function DUF72
I5I21_RS16820	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I5I21_RS16840	COG3102	Protein conserved in bacteria
I5I21_RS16850	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I5I21_RS16875	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5I21_RS16885	COG1879	ABC-type sugar transport system periplasmic component
I5I21_RS16895	COG1528	Iron-storage protein
I5I21_RS16905	COG2211	Major facilitator Superfamily
I5I21_RS16915	COG0477	Major facilitator Superfamily
I5I21_RS16930	COG1528	Iron-storage protein
I5I21_RS16940	COG0814	amino acid
I5I21_RS16945	COG3012	SEC-C Motif Domain Protein
I5I21_RS16945	COG3318	Belongs to the UPF0149 family
I5I21_RS16980	COG2197	response regulator
I5I21_RS16990	COG2197	response regulator
I5I21_RS16995	COG1126	abc transporter atp-binding protein
I5I21_RS17000	COG0765	amino acid transport
I5I21_RS17010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5I21_RS17015	COG0366	Alpha amylase catalytic
I5I21_RS17045	COG2354	Protein conserved in bacteria
I5I21_RS17050	COG0697	spore germination
I5I21_RS17055	COG3727	T/G mismatch-specific endonuclease activity
I5I21_RS17060	COG0270	DNA (cytosine-5-)-methyltransferase activity
I5I21_RS17065	COG1418	mRNA catabolic process
I5I21_RS17075	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I5I21_RS17095	COG0251	oxidation-reduction process
I5I21_RS17125	COG0025	NhaP-type Na H and K H
I5I21_RS17130	COG1309	transcriptional regulator
I5I21_RS17135	COG0604	alcohol dehydrogenase
I5I21_RS17155	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I5I21_RS17165	COG0534	Mate efflux family protein
I5I21_RS17185	COG3706	GGDEF domain
I5I21_RS17210	COG3615	Tellurite resistance protein tehB
I5I21_RS17220	COG5001	Diguanylate cyclase
I5I21_RS17220	COG3300	MHYT domain
I5I21_RS17230	COG0477	Major facilitator Superfamily
I5I21_RS17235	COG0095	Lipoate-protein ligase
I5I21_RS17240	COG0583	DNA-binding transcription factor activity
I5I21_RS17245	COG1942	4-Oxalocrotonate Tautomerase
I5I21_RS17255	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I5I21_RS17275	COG1289	transmembrane transporter activity
I5I21_RS17285	COG3344	reverse transcriptase
I5I21_RS17295	COG2925	Exonuclease
I5I21_RS17300	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I5I21_RS17305	COG0640	Transcriptional regulator
I5I21_RS17310	COG0531	amino acid
I5I21_RS17320	COG0583	DNA-binding transcription factor activity
I5I21_RS17325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I5I21_RS17355	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I5I21_RS17380	COG0463	Glycosyl transferase, family 2
I5I21_RS17390	COG1442	glycosyl transferase family 8
I5I21_RS17390	COG1216	Glycosyl transferase, family 2
I5I21_RS17395	COG0438	transferase activity, transferring glycosyl groups
I5I21_RS17470	COG0463	Glycosyl transferase, family 2
I5I21_RS17530	COG1253	flavin adenine dinucleotide binding
I5I21_RS17535	COG2982	Protein involved in outer membrane biogenesis
I5I21_RS17550	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I5I21_RS17555	COG0443	Heat shock 70 kDa protein
I5I21_RS17560	COG5002	protein histidine kinase activity
I5I21_RS17580	COG1301	dicarboxylic acid transport
I5I21_RS17605	COG2205	protein histidine kinase activity
I5I21_RS17610	COG0745	RESPONSE REGULATOR receiver
I5I21_RS17615	COG0826	peptidase U32
I5I21_RS17625	COG4608	Belongs to the ABC transporter superfamily
I5I21_RS17630	COG0444	Belongs to the ABC transporter superfamily
I5I21_RS17635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5I21_RS17640	COG0601	transmembrane transport
I5I21_RS17645	COG0747	negative chemotaxis
I5I21_RS17650	COG4948	Mandelate Racemase Muconate Lactonizing
I5I21_RS17655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5I21_RS17665	COG1070	Carbohydrate kinase
I5I21_RS17700	COG1830	Aldolase
I5I21_RS17705	COG0351	phosphomethylpyrimidine kinase
I5I21_RS17720	COG0583	DNA-binding transcription factor activity
I5I21_RS17730	COG2252	PERMEase
I5I21_RS17735	COG0583	DNA-binding transcription factor activity
I5I21_RS17740	COG5455	response to cobalt ion
I5I21_RS17760	COG4807	Protein conserved in bacteria
I5I21_RS17770	COG3275	phosphorelay sensor kinase activity
I5I21_RS17780	COG1174	glycine betaine transport
I5I21_RS17785	COG1125	glycine betaine transport
I5I21_RS17790	COG1174	glycine betaine transport
I5I21_RS17795	COG1732	Glycine betaine
I5I21_RS17800	COG1472	Belongs to the glycosyl hydrolase 3 family
I5I21_RS17805	COG0277	FAD linked oxidase domain protein
I5I21_RS17815	COG1686	Belongs to the peptidase S11 family
I5I21_RS17825	COG0586	Pfam SNARE associated Golgi protein
I5I21_RS17830	COG1538	Outer membrane efflux protein
I5I21_RS17835	COG2723	6-phospho-beta-galactosidase activity
I5I21_RS17850	COG3659	wide pore channel activity
I5I21_RS17855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I5I21_RS17865	COG1346	cytolysis
I5I21_RS17875	COG2949	membrane
I5I21_RS17885	COG1129	ABC transporter
I5I21_RS17900	COG2311	Membrane
I5I21_RS17915	COG4771	TonB-dependent receptor
I5I21_RS17920	COG0833	amino acid
I5I21_RS17925	COG0583	DNA-binding transcription factor activity
I5I21_RS17930	COG2855	membrane
I5I21_RS17940	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5I21_RS17940	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I5I21_RS17940	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5I21_RS17945	COG1105	Belongs to the carbohydrate kinase PfkB family
I5I21_RS17950	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5I21_RS17950	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5I21_RS17955	COG2814	Major facilitator Superfamily
I5I21_RS17975	COG1312	Catalyzes the dehydration of D-mannonate
I5I21_RS17980	COG0246	Mannitol dehydrogenase
I5I21_RS17985	COG0523	cobalamin synthesis protein
I5I21_RS17990	COG0671	phosphoesterase, PA-phosphatase related
I5I21_RS17995	COG0791	NLP P60 protein
I5I21_RS18000	COG2200	EAL domain
I5I21_RS18005	COG4166	transmembrane transport
I5I21_RS18010	COG4174	ABC transporter (Permease)
I5I21_RS18015	COG4239	(ABC) transporter, permease
I5I21_RS18020	COG4172	Belongs to the ABC transporter superfamily
I5I21_RS18030	COG2814	Major facilitator Superfamily
I5I21_RS18035	COG1187	pseudouridine synthase activity
I5I21_RS18040	COG1061	Type III restriction enzyme res subunit
I5I21_RS18060	COG0494	nUDIX hydrolase
I5I21_RS18065	COG1349	DNA-binding transcription factor activity
I5I21_RS18090	COG0628	permease
I5I21_RS18105	COG0659	secondary active sulfate transmembrane transporter activity
I5I21_RS18110	COG2239	Acts as a magnesium transporter
I5I21_RS18115	COG4615	Cyclic peptide transporter
I5I21_RS18120	COG3145	DNA-N1-methyladenine dioxygenase activity
I5I21_RS18125	COG2169	Transcriptional regulator
I5I21_RS18125	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I5I21_RS18140	COG0642	Histidine kinase
I5I21_RS18140	COG2198	Histidine kinase
I5I21_RS18150	COG2205	protein histidine kinase activity
I5I21_RS18150	COG0784	Response regulator, receiver
I5I21_RS18175	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5I21_RS18180	COG0584	glycerophosphoryl diester phosphodiesterase
I5I21_RS18185	COG2271	Major facilitator Superfamily
I5I21_RS18190	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I5I21_RS18200	COG0247	lactate metabolic process
I5I21_RS18210	COG2271	Major facilitator Superfamily
I5I21_RS18220	COG1414	Transcriptional regulator
I5I21_RS18235	COG5464	transposase or invertase
I5I21_RS18245	COG0318	PFAM AMP-dependent synthetase and ligase
I5I21_RS18270	COG1169	isochorismate synthase
I5I21_RS18275	COG2153	protein acetylation
I5I21_RS18290	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I5I21_RS18295	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I5I21_RS18305	COG0839	Belongs to the complex I subunit 6 family
I5I21_RS18350	COG0583	DNA-binding transcription factor activity
I5I21_RS18355	COG0436	Aminotransferase
I5I21_RS18365	COG0490	domain, Protein
I5I21_RS18365	COG0471	metal ion transport
I5I21_RS18370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5I21_RS18390	COG0857	belongs to the CobB CobQ family
I5I21_RS18390	COG0280	phosphate acetyltransferase
I5I21_RS18395	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I5I21_RS18400	COG0622	Phosphoesterase
I5I21_RS18405	COG0625	glutathione transferase activity
I5I21_RS18410	COG0625	glutathione transferase activity
I5I21_RS18415	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I5I21_RS18420	COG1090	epimerase
I5I21_RS18435	COG4598	ABC transporter
I5I21_RS18440	COG4160	amino acid transport
I5I21_RS18465	COG0163	prenyltransferase activity
I5I21_RS18470	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I5I21_RS18475	COG1286	toxin biosynthetic process
I5I21_RS18480	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I5I21_RS18485	COG0285	dihydrofolate synthase activity
I5I21_RS18495	COG0586	Pfam SNARE associated Golgi protein
I5I21_RS18505	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I5I21_RS18525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I5I21_RS18540	COG3101	peptidyl-lysine hydroxylation
I5I21_RS18545	COG0730	response to heat
I5I21_RS18570	COG2062	phosphohistidine phosphatase, SixA
I5I21_RS18585	COG3691	Protein conserved in bacteria
I5I21_RS18595	COG2853	Lipoprotein
I5I21_RS18600	COG2116	formate transmembrane transporter activity
I5I21_RS18620	COG0583	DNA-binding transcription factor activity
I5I21_RS18625	COG0590	tRNA wobble adenosine to inosine editing
I5I21_RS18630	COG2807	transmembrane transport
I5I21_RS18640	COG0436	Aminotransferase
I5I21_RS18655	COG3275	phosphorelay sensor kinase activity
I5I21_RS18660	COG3279	Response regulator of the LytR AlgR family
I5I21_RS18675	COG3961	Belongs to the TPP enzyme family
I5I21_RS18680	COG0667	Aldo Keto reductase
I5I21_RS18695	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I5I21_RS18700	COG2200	EAL domain
I5I21_RS18700	COG2199	diguanylate cyclase activity
I5I21_RS18715	COG3415	Transposase
I5I21_RS18720	COG3415	Transposase
I5I21_RS18750	COG0583	DNA-binding transcription factor activity
I5I21_RS18755	COG0385	Bile acid
I5I21_RS18760	COG3530	Putative quorum-sensing-regulated virulence factor
I5I21_RS18780	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I5I21_RS18815	COG4319	ketosteroid isomerase
I5I21_RS18825	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I5I21_RS18830	COG4208	sulfate ABC transporter
I5I21_RS18835	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I5I21_RS18840	COG4150	thiosulfate binding
I5I21_RS18850	COG2837	iron assimilation
I5I21_RS18870	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5I21_RS18960	COG4810	utilization protein
I5I21_RS18970	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I5I21_RS18975	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I5I21_RS18980	COG5342	invasion associated locus B
I5I21_RS18990	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I5I21_RS18990	COG0493	'glutamate synthase
I5I21_RS18995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5I21_RS19005	COG1393	Belongs to the ArsC family
I5I21_RS19020	COG0400	carboxylic ester hydrolase activity
I5I21_RS19025	COG1444	tRNA N-acetyltransferase activity
I5I21_RS19030	COG2321	neutral zinc metallopeptidase
I5I21_RS19040	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I5I21_RS19050	COG2716	regulation of RNA biosynthetic process
I5I21_RS19055	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I5I21_RS19060	COG0628	permease
I5I21_RS19070	COG4783	chaperone-mediated protein folding
I5I21_RS19075	COG1393	Belongs to the ArsC family
I5I21_RS19090	COG2233	PERMEase
I5I21_RS19100	COG2723	6-phospho-beta-galactosidase activity
I5I21_RS19115	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I5I21_RS19130	COG2200	EAL domain
I5I21_RS19150	COG0641	radical SAM
I5I21_RS19155	COG3119	arylsulfatase activity
I5I21_RS19165	COG3179	chitinase
I5I21_RS19190	COG3344	reverse transcriptase
I5I21_RS19200	COG3617	BRO family, N-terminal domain
I5I21_RS19300	COG3728	DNA packaging
I5I21_RS19300	COG5484	DNA packaging
I5I21_RS19395	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I5I21_RS19440	COG0517	IMP dehydrogenase activity
I5I21_RS19440	COG0516	GMP reductase activity
I5I21_RS19450	COG1645	bacterial-type flagellum-dependent swarming motility
I5I21_RS19470	COG2976	Protein conserved in bacteria
I5I21_RS19500	COG4953	penicillin-binding protein 1C
I5I21_RS19505	COG2373	Large extracellular alpha-helical protein
I5I21_RS19510	COG2897	thiosulfate sulfurtransferase activity
I5I21_RS19530	COG2975	iron-sulfur cluster assembly
I5I21_RS19535	COG0633	Ferredoxin
I5I21_RS19555	COG0822	iron-sulfur transferase activity
I5I21_RS19585	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I5I21_RS19590	COG3683	transport system, periplasmic component
I5I21_RS19595	COG3711	transcriptional antiterminator
I5I21_RS19600	COG2814	Major facilitator Superfamily
I5I21_RS19605	COG2017	converts alpha-aldose to the beta-anomer
I5I21_RS19610	COG0477	Major facilitator Superfamily
I5I21_RS19610	COG2814	Major facilitator Superfamily
I5I21_RS19615	COG0457	Tetratricopeptide repeat
I5I21_RS19620	COG1940	carbohydrate kinase activity
I5I21_RS19625	COG2259	Doxx family
I5I21_RS19635	COG1017	nitric oxide dioxygenase activity
I5I21_RS19635	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5I21_RS19640	COG0347	Belongs to the P(II) protein family
I5I21_RS19645	COG2204	response regulator
I5I21_RS19650	COG3170	Tfp pilus assembly protein FimV
I5I21_RS19655	COG2205	protein histidine kinase activity
I5I21_RS19660	COG0047	phosphoribosylformylglycinamidine synthase activity
I5I21_RS19660	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I5I21_RS19675	COG0560	Phosphoserine phosphatase
I5I21_RS19680	COG1737	Transcriptional regulator
I5I21_RS19685	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I5I21_RS19695	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I5I21_RS19715	COG0681	Belongs to the peptidase S26 family
I5I21_RS19725	COG3086	response to oxidative stress
I5I21_RS19730	COG3026	antisigma factor binding
I5I21_RS19735	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I5I21_RS19750	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I5I21_RS19760	COG0513	Belongs to the DEAD box helicase family
I5I21_RS19775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I5I21_RS19780	COG3118	belongs to the thioredoxin family
I5I21_RS19785	COG3148	PFAM DTW domain containing protein
I5I21_RS19795	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5I21_RS19800	COG5544	Lipoprotein
I5I21_RS19805	COG0477	Major facilitator Superfamily
I5I21_RS19830	COG0542	response to heat
I5I21_RS19845	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I5I21_RS19850	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I5I21_RS19860	COG1605	Chorismate mutase
I5I21_RS19860	COG0077	Prephenate dehydratase
I5I21_RS19870	COG1605	Chorismate mutase
I5I21_RS19870	COG0287	Prephenate dehydrogenase
I5I21_RS19875	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I5I21_RS19885	COG2199	diguanylate cyclase activity
I5I21_RS19890	COG2885	chlorophyll binding
I5I21_RS19925	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I5I21_RS19930	COG4137	Cytochrome C assembly protein
I5I21_RS19935	COG4536	flavin adenine dinucleotide binding
I5I21_RS19950	COG0497	DNA recombination
I5I21_RS19965	COG2867	negative regulation of translational initiation
I5I21_RS20140	COG4695	Portal protein
I5I21_RS20175	COG3344	reverse transcriptase
I5I21_RS20190	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I5I21_RS20225	COG4974	Belongs to the 'phage' integrase family
I5I21_RS20250	COG3708	Transcriptional regulator
I5I21_RS20250	COG2207	Transcriptional regulator
I5I21_RS20255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5I21_RS20290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5I21_RS20300	COG0235	Class ii aldolase
I5I21_RS20310	COG1028	Short-chain dehydrogenase reductase Sdr
I5I21_RS20325	COG2197	response regulator
I5I21_RS20330	COG3539	Fimbrial protein
I5I21_RS20340	COG3188	usher protein
I5I21_RS20360	COG3121	Chaperone
I5I21_RS20365	COG3539	Fimbrial protein
I5I21_RS20375	COG3284	Transcriptional regulator
I5I21_RS20380	COG0583	DNA-binding transcription factor activity
I5I21_RS20390	COG0640	Transcriptional regulator
I5I21_RS20395	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5I21_RS20410	COG2916	Histone family protein nucleoid-structuring protein H-NS
I5I21_RS20425	COG4575	ribosome binding
I5I21_RS20430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5I21_RS20435	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5I21_RS20440	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I5I21_RS20450	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I5I21_RS20465	COG4176	ABC-type proline glycine betaine transport system permease component
I5I21_RS20475	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I5I21_RS20485	COG1846	Transcriptional regulator
I5I21_RS20490	COG1566	PFAM secretion protein HlyD family protein
I5I21_RS20495	COG2814	Major facilitator Superfamily
I5I21_RS20500	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I5I21_RS20520	COG1238	metal cluster binding
I5I21_RS20525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5I21_RS20530	COG2823	Periplasmic or secreted lipoprotein
I5I21_RS20560	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I5I21_RS20580	COG1546	Belongs to the CinA family
I5I21_RS20590	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5I21_RS20595	COG1121	(ABC) transporter
I5I21_RS20600	COG2951	lytic endotransglycosylase activity
I5I21_RS20605	COG3730	PTS system glucitol sorbitol-specific
I5I21_RS20610	COG3732	PTS system glucitol sorbitol-specific
I5I21_RS20620	COG1028	Short-chain dehydrogenase reductase Sdr
I5I21_RS20625	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5I21_RS20630	COG1349	DNA-binding transcription factor activity
I5I21_RS20655	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
I5I21_RS20660	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I5I21_RS20665	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I5I21_RS20670	COG1609	Transcriptional regulator
I5I21_RS20675	COG1263	PTS System
I5I21_RS20675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5I21_RS20680	COG2723	6-phospho-beta-galactosidase activity
I5I21_RS20690	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I5I21_RS20700	COG3260	NADH ubiquinone oxidoreductase 20
I5I21_RS20705	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I5I21_RS20710	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I5I21_RS20710	COG3261	NADH dehydrogenase
I5I21_RS20715	COG0650	Formate hydrogenlyase subunit 4
I5I21_RS20720	COG0651	ATP synthesis coupled electron transport
I5I21_RS20725	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I5I21_RS20740	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I5I21_RS20745	COG0298	carbon dioxide binding
I5I21_RS20750	COG0409	Hydrogenase expression formation protein
I5I21_RS20755	COG0309	Hydrogenase expression formation protein (HypE)
I5I21_RS20765	COG2723	6-phospho-beta-galactosidase activity
I5I21_RS20775	COG4580	involved in the transport of maltose and maltodextrins
I5I21_RS20780	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5I21_RS20785	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5I21_RS20790	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5I21_RS20795	COG1447	Phosphotransferase system cellobiose-specific component IIA
I5I21_RS20800	COG1940	carbohydrate kinase activity
I5I21_RS20805	COG1609	Transcriptional regulator
I5I21_RS20810	COG0803	Belongs to the bacterial solute-binding protein 9 family
I5I21_RS20815	COG1121	(ABC) transporter
I5I21_RS20820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5I21_RS20825	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5I21_RS20840	COG0679	Auxin Efflux Carrier
I5I21_RS20860	COG3720	iron ion transport
I5I21_RS20865	COG4558	Periplasmic binding protein
I5I21_RS20870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5I21_RS20910	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I5I21_RS20915	COG0163	prenyltransferase activity
I5I21_RS20940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I5I21_RS20945	COG1388	LysM domain
I5I21_RS20945	COG4942	peptidase
I5I21_RS21005	COG2234	aminopeptidase activity
I5I21_RS21025	COG0720	synthase
I5I21_RS21030	COG0602	queuosine metabolic process
I5I21_RS21050	COG3956	TIGRFAM MazG family protein
I5I21_RS21055	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I5I21_RS21065	COG3437	response regulator, receiver
I5I21_RS21065	COG4999	Histidine kinase
I5I21_RS21065	COG2205	protein histidine kinase activity
I5I21_RS21065	COG3850	Histidine kinase
I5I21_RS21070	COG1929	Belongs to the glycerate kinase type-1 family
I5I21_RS21075	COG4948	Mandelate Racemase Muconate Lactonizing
I5I21_RS21080	COG4948	Mandelate Racemase Muconate Lactonizing
I5I21_RS21085	COG2271	Major facilitator Superfamily
I5I21_RS21090	COG0716	FMN binding
I5I21_RS21095	COG0564	pseudouridine synthase activity
I5I21_RS21100	COG3098	single-species biofilm formation
I5I21_RS21115	COG1611	Belongs to the LOG family
I5I21_RS21120	COG0814	amino acid
I5I21_RS21125	COG1760	l-serine dehydratase
I5I21_RS21130	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5I21_RS21140	COG0477	Major facilitator Superfamily
I5I21_RS21145	COG1464	Belongs to the NlpA lipoprotein family
I5I21_RS21150	COG2011	ABC-type metal ion transport system permease component
I5I21_RS21155	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I5I21_RS21170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5I21_RS21190	COG1454	alcohol dehydrogenase
I5I21_RS21195	COG0235	Class ii aldolase
I5I21_RS21200	COG0738	Major facilitator superfamily
I5I21_RS21220	COG1349	DNA-binding transcription factor activity
I5I21_RS21230	COG2363	Small membrane protein
I5I21_RS21235	COG0583	DNA-binding transcription factor activity
I5I21_RS21245	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I5I21_RS21250	COG2166	iron-sulfur cluster assembly
I5I21_RS21255	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I5I21_RS21260	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I5I21_RS21425	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I5I21_RS21455	COG1454	alcohol dehydrogenase
I5I21_RS21455	COG1012	belongs to the aldehyde dehydrogenase family
I5I21_RS21460	COG4656	Part of a membrane complex involved in electron transport
I5I21_RS21490	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I5I21_RS21495	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5I21_RS21500	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I5I21_RS21500	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I5I21_RS21510	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I5I21_RS21515	COG1074	ATP-dependent DNA helicase activity
I5I21_RS21520	COG1025	Belongs to the peptidase M16 family
I5I21_RS21525	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I5I21_RS21530	COG4967	type IV pilus modification protein PilV
I5I21_RS21540	COG4795	General secretion pathway protein
I5I21_RS21545	COG2165	general secretion pathway protein
I5I21_RS21580	COG0861	Integral membrane protein TerC family
I5I21_RS21590	COG0667	Aldo Keto reductase
I5I21_RS21610	COG1609	Transcriptional regulator
I5I21_RS21620	COG2186	Transcriptional regulator
I5I21_RS21625	COG2723	6-phospho-beta-galactosidase activity
I5I21_RS21630	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5I21_RS21635	COG1609	Transcriptional regulator
I5I21_RS21645	COG0583	DNA-binding transcription factor activity
I5I21_RS21650	COG1794	racemase activity, acting on amino acids and derivatives
I5I21_RS21655	COG1917	Cupin 2, conserved barrel domain protein
I5I21_RS21660	COG1175	transmembrane transport
I5I21_RS21665	COG0395	ABC-type sugar transport system, permease component
I5I21_RS21670	COG3842	ATPase activity
I5I21_RS21705	COG2814	Major facilitator Superfamily
I5I21_RS21710	COG1028	Short-chain dehydrogenase reductase Sdr
I5I21_RS21715	COG0823	Involved in the tonB-independent uptake of proteins
I5I21_RS21725	COG0183	Belongs to the thiolase family
I5I21_RS21740	COG0814	amino acid
I5I21_RS21745	COG0667	Aldo Keto reductase
I5I21_RS21795	COG0697	spore germination
I5I21_RS21800	COG1846	Transcriptional regulator
I5I21_RS21805	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I5I21_RS21810	COG0582	viral genome integration into host DNA
I5I21_RS21815	COG4974	Belongs to the 'phage' integrase family
I5I21_RS21825	COG3539	Fimbrial protein
I5I21_RS21830	COG3121	Chaperone
I5I21_RS21840	COG3539	Fimbrial protein
I5I21_RS21845	COG3539	Fimbrial protein
I5I21_RS21850	COG3539	Fimbrial protein
I5I21_RS21860	COG2388	GCN5-related N-acetyl-transferase
I5I21_RS21865	COG3592	Divergent 4Fe-4S mono-cluster
I5I21_RS21880	COG1289	transmembrane transporter activity
I5I21_RS21885	COG1538	Outer membrane efflux protein
I5I21_RS21900	COG1393	Belongs to the ArsC family
I5I21_RS21905	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I5I21_RS21940	COG0667	Aldo Keto reductase
I5I21_RS21955	COG2814	Major facilitator Superfamily
I5I21_RS21980	COG4974	Belongs to the 'phage' integrase family
I5I21_RS21990	COG4942	peptidase
I5I21_RS22010	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I5I21_RS22020	COG4974	Belongs to the 'phage' integrase family
I5I21_RS22025	COG0716	FMN binding
I5I21_RS22035	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I5I21_RS22045	COG1272	protein, Hemolysin III
I5I21_RS22055	COG1737	Transcriptional regulator
I5I21_RS22060	COG2723	6-phospho-beta-galactosidase activity
I5I21_RS22080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5I21_RS22085	COG1028	Short-chain dehydrogenase reductase Sdr
I5I21_RS22105	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5I21_RS22110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5I21_RS22115	COG0006	proline dipeptidase activity
I5I21_RS22135	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I5I21_RS22140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5I21_RS22155	COG2968	Membrane
I5I21_RS22165	COG0668	transmembrane transport
I5I21_RS22170	COG0191	fructose-bisphosphate aldolase activity
I5I21_RS22185	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I5I21_RS22190	COG0501	Belongs to the peptidase M48B family
I5I21_RS22210	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
I5I21_RS22215	COG1028	Short-chain dehydrogenase reductase Sdr
I5I21_RS22245	COG1414	Transcriptional regulator
I5I21_RS22250	COG1028	Short-chain dehydrogenase reductase Sdr
I5I21_RS22265	COG2146	nitrite reductase [NAD(P)H] activity
I5I21_RS22305	COG2814	Major facilitator Superfamily
I5I21_RS22315	COG2356	endonuclease I
I5I21_RS22320	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I5I21_RS22325	COG0189	ligase activity
I5I21_RS22345	COG2805	Type II/IV secretion system protein
I5I21_RS22350	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I5I21_RS22355	COG0762	integral membrane protein
I5I21_RS22370	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I5I21_RS22380	COG3171	Protein conserved in bacteria
I5I21_RS22390	COG1194	a g-specific adenine glycosylase
I5I21_RS22405	COG2211	Major facilitator Superfamily
I5I21_RS22410	COG1982	Orn Lys Arg decarboxylase major
I5I21_RS22415	COG1811	Na channel or pump
I5I21_RS22425	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I5I21_RS22500	COG3423	Transcriptional regulator
I5I21_RS22505	COG1278	Cold shock
I5I21_RS22515	COG3423	Transcriptional regulator
I5I21_RS22770	COG0626	cystathionine gamma-synthase activity
I5I21_RS22775	COG0583	DNA-binding transcription factor activity
I5I21_RS22795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5I21_RS22800	COG0754	glutathionylspermidine amidase activity
I5I21_RS22815	COG0625	glutathione transferase activity
I5I21_RS22840	COG2211	Major facilitator Superfamily
I5I21_RS22845	COG0848	biopolymer transport protein
I5I21_RS22855	COG0626	cystathionine gamma-synthase activity
I5I21_RS22860	COG0586	Pfam SNARE associated Golgi protein
I5I21_RS22865	COG2207	Transcriptional regulator
I5I21_RS22870	COG1979	alcohol dehydrogenase
I5I21_RS22875	COG0656	L-ascorbic acid biosynthetic process
I5I21_RS22885	COG1032	radical SAM domain protein
I5I21_RS22890	COG2132	Multicopper oxidase
I5I21_RS22895	COG0204	Acyl-transferase
I5I21_RS22900	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I5I21_RS22905	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I5I21_RS22910	COG3111	PFAM Bacterial OB fold (BOF) protein
I5I21_RS22920	COG0642	Histidine kinase
I5I21_RS22925	COG2249	NAD(P)H dehydrogenase (quinone) activity
I5I21_RS22930	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I5I21_RS22940	COG3150	esterase
I5I21_RS22945	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I5I21_RS22950	COG3151	Protein conserved in bacteria
I5I21_RS22955	COG0494	nUDIX hydrolase
I5I21_RS22970	COG0754	glutathionylspermidine amidase activity
I5I21_RS22975	COG3384	dioxygenase
I5I21_RS22990	COG2960	long-chain fatty acid transporting porin activity
I5I21_RS23015	COG3025	triphosphatase activity
I5I21_RS23020	COG4991	sh3 domain protein
I5I21_RS23035	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I5I21_RS23100	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I5I21_RS23105	COG0358	DNA primase activity
I5I21_RS23110	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I5I21_RS23135	COG2197	response regulator
I5I21_RS23140	COG2205	protein histidine kinase activity
I5I21_RS23140	COG0784	Response regulator, receiver
I5I21_RS23140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5I21_RS23140	COG2198	Histidine kinase
I5I21_RS23150	COG3247	response to pH
I5I21_RS23220	COG2376	Dihydroxyacetone kinase
I5I21_RS23225	COG1461	Dihydroxyacetone kinase
I5I21_RS23240	COG2375	cellular response to nickel ion
I5I21_RS23245	COG1695	Transcriptional regulator
I5I21_RS23295	COG1902	pentaerythritol trinitrate reductase activity
I5I21_RS23295	COG0446	pyridine nucleotide-disulphide oxidoreductase
I5I21_RS23315	COG1451	nucleotide metabolic process
I5I21_RS23320	COG0673	inositol 2-dehydrogenase activity
I5I21_RS23325	COG0861	Integral membrane protein TerC family
I5I21_RS23340	COG2721	sulfolactate sulfo-lyase activity
I5I21_RS23350	COG2271	Major facilitator Superfamily
I5I21_RS23355	COG2186	Transcriptional regulator
I5I21_RS23360	COG0586	Pfam SNARE associated Golgi protein
I5I21_RS23370	COG1422	Protein of unknown function (DUF1090)
I5I21_RS23375	COG4575	ribosome binding
I5I21_RS23380	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I5I21_RS23390	COG2259	Doxx family
I5I21_RS23395	COG0435	Glutathione S-transferase
I5I21_RS23400	COG3152	Membrane
I5I21_RS23410	COG0583	DNA-binding transcription factor activity
I5I21_RS23415	COG1741	Belongs to the pirin family
I5I21_RS23440	COG1929	Belongs to the glycerate kinase type-1 family
I5I21_RS23445	COG2084	Dehydrogenase
I5I21_RS23455	COG2271	Major facilitator Superfamily
I5I21_RS23460	COG2721	sulfolactate sulfo-lyase activity
I5I21_RS23465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5I21_RS23470	COG1349	DNA-binding transcription factor activity
I5I21_RS23480	COG1105	Belongs to the carbohydrate kinase PfkB family
I5I21_RS23485	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5I21_RS23485	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5I21_RS23485	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5I21_RS23490	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5I21_RS23490	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5I21_RS23500	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5I21_RS23505	COG3414	Phosphotransferase system galactitol-specific IIB component
I5I21_RS23510	COG3775	system Galactitol-specific IIC component
I5I21_RS23515	COG1063	alcohol dehydrogenase
I5I21_RS23530	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I5I21_RS23550	COG2823	Periplasmic or secreted lipoprotein
I5I21_RS23555	COG0701	Predicted permease
I5I21_RS23560	COG0702	epimerase
I5I21_RS23565	COG0693	protein deglycase activity
I5I21_RS23580	COG3153	acetyltransferase
I5I21_RS23585	COG3154	lipid carrier protein
I5I21_RS23590	COG0826	peptidase U32
I5I21_RS23595	COG0826	peptidase U32
I5I21_RS23600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5I21_RS23605	COG0814	amino acid
I5I21_RS23650	COG0195	Participates in both transcription termination and antitermination
I5I21_RS23690	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I5I21_RS23700	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I5I21_RS23705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I5I21_RS23715	COG1534	Rna-binding protein
I5I21_RS23725	COG2027	D-alanyl-D-alanine carboxypeptidase
I5I21_RS23735	COG0697	spore germination
I5I21_RS23750	COG0142	geranyltranstransferase activity
I5I21_RS23755	COG3423	Transcriptional regulator
I5I21_RS23765	COG5007	Belongs to the BolA IbaG family
I5I21_RS23770	COG3113	response to antibiotic
I5I21_RS23775	COG2854	intermembrane phospholipid transfer
I5I21_RS23780	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I5I21_RS23785	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I5I21_RS23790	COG1127	ABC transporter
I5I21_RS23795	COG0530	calcium, potassium:sodium antiporter activity
I5I21_RS23805	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I5I21_RS23810	COG3117	lipopolysaccharide transmembrane transporter activity
I5I21_RS23815	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I5I21_RS23820	COG1137	ATPase activity
I5I21_RS23825	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I5I21_RS23830	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I5I21_RS23835	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5I21_RS23845	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5I21_RS23850	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I5I21_RS23855	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I5I21_RS23860	COG2198	Histidine kinase
I5I21_RS23860	COG5002	protein histidine kinase activity
I5I21_RS23860	COG0784	Response regulator, receiver
I5I21_RS23865	COG1312	Catalyzes the dehydration of D-mannonate
I5I21_RS23870	COG1063	alcohol dehydrogenase
I5I21_RS23875	COG2271	Major facilitator Superfamily
I5I21_RS23880	COG1242	4 iron, 4 sulfur cluster binding
I5I21_RS23885	COG0070	glutamate synthase
I5I21_RS23885	COG0067	glutamate synthase
I5I21_RS23885	COG0069	glutamate synthase activity
I5I21_RS23890	COG0493	'glutamate synthase
I5I21_RS23900	COG2969	positive regulation of protein catabolic process
I5I21_RS23905	COG0625	glutathione transferase activity
I5I21_RS23925	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I5I21_RS23930	COG3105	Protein conserved in bacteria
I5I21_RS23935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5I21_RS23940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5I21_RS23965	COG2732	(Barnase) inhibitor
I5I21_RS23970	COG1289	transmembrane transporter activity
I5I21_RS23985	COG0583	DNA-binding transcription factor activity
I5I21_RS23990	COG0312	modulator of DNA gyrase
I5I21_RS23995	COG3164	Protein of unknown function
I5I21_RS24000	COG1530	ribonuclease E activity
I5I21_RS24010	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I5I21_RS24015	COG1792	Involved in formation and maintenance of cell shape
I5I21_RS24020	COG1077	Cell shape determining protein MreB Mrl
I5I21_RS24025	COG2200	EAL domain
I5I21_RS24025	COG2199	diguanylate cyclase activity
I5I21_RS24050	COG0511	ligase activity, forming carbon-carbon bonds
I5I21_RS24055	COG0439	Biotin carboxylase
I5I21_RS24060	COG3924	membrane
I5I21_RS24065	COG4145	pantothenate transmembrane transporter activity
I5I21_RS24090	COG4626	Terminase
I5I21_RS24090	COG1802	Transcriptional regulator
I5I21_RS24175	COG3561	AntA/AntB antirepressor
I5I21_RS24190	COG0582	viral genome integration into host DNA
I5I21_RS24195	COG1309	transcriptional regulator
I5I21_RS24200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5I21_RS24205	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5I21_RS24240	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I5I21_RS24260	COG0551	DNA topoisomerase type I activity
I5I21_RS24270	COG0758	DNA mediated transformation
I5I21_RS24300	COG3036	rescue of stalled ribosome
I5I21_RS24305	COG0789	Transcriptional regulator
I5I21_RS24320	COG0202	RNA polymerase activity
I5I21_RS24345	COG0201	protein transport
I5I21_RS24410	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I5I21_RS24425	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I5I21_RS24450	COG0051	transcription antitermination factor activity, RNA binding
I5I21_RS24505	COG2964	Protein conserved in bacteria
I5I21_RS24510	COG0545	Peptidyl-prolyl cis-trans isomerase
I5I21_RS24520	COG1047	Peptidyl-prolyl cis-trans
I5I21_RS24525	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I5I21_RS24540	COG0488	(ABC) transporter
I5I21_RS24545	COG0429	hydrolase of the alpha beta-hydrolase fold
I5I21_RS24555	COG3954	Phosphoribulokinase
I5I21_RS24560	COG1765	OsmC-like protein
I5I21_RS24570	COG1289	transmembrane transporter activity
I5I21_RS24575	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I5I21_RS24600	COG0738	Major facilitator superfamily
I5I21_RS24605	COG0402	S-adenosylhomocysteine deaminase activity
I5I21_RS24610	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I5I21_RS24635	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I5I21_RS24640	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I5I21_RS24645	COG3266	domain, Protein
I5I21_RS24660	COG4796	Type ii and iii secretion system protein
I5I21_RS24685	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I5I21_RS24690	COG0494	nUDIX hydrolase
I5I21_RS24700	COG1011	Hydrolase
I5I21_RS24705	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I5I21_RS24730	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I5I21_RS24735	COG2183	response to ionizing radiation
I5I21_RS24740	COG1918	ferrous iron import across plasma membrane
I5I21_RS24765	COG1040	competence protein
I5I21_RS24775	COG2610	gluconate transmembrane transporter activity
I5I21_RS24780	COG1640	4-alpha-glucanotransferase
I5I21_RS24785	COG0058	SHG alpha-glucan phosphorylase activity
I5I21_RS24795	COG1349	DNA-binding transcription factor activity
I5I21_RS24810	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I5I21_RS24825	COG0058	SHG alpha-glucan phosphorylase activity
I5I21_RS24850	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I5I21_RS24860	COG2610	gluconate transmembrane transporter activity
I5I21_RS24865	COG3265	gluconokinase activity
I5I21_RS24870	COG1609	Transcriptional regulator
I5I21_RS24875	COG1741	Belongs to the pirin family
I5I21_RS24880	COG0673	inositol 2-dehydrogenase activity
I5I21_RS24890	COG1247	-acetyltransferase
I5I21_RS24895	COG0405	Gamma-glutamyltransferase
I5I21_RS24905	COG0584	glycerophosphoryl diester phosphodiesterase
I5I21_RS24955	COG0559	Belongs to the binding-protein-dependent transport system permease family
I5I21_RS24960	COG0683	leucine binding
I5I21_RS24970	COG0683	leucine binding
I5I21_RS24980	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I5I21_RS24995	COG2177	Part of the ABC transporter FtsEX involved in
I5I21_RS25000	COG2884	Cell division ATP-binding protein ftsE
I5I21_RS25005	COG0552	protein localization to endoplasmic reticulum
I5I21_RS25010	COG0742	ribosomal rna small subunit methyltransferase
I5I21_RS25015	COG3776	membrane
I5I21_RS25025	COG3714	YhhN family
I5I21_RS25040	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I5I21_RS25050	COG0477	Major facilitator Superfamily
I5I21_RS25055	COG0628	permease
I5I21_RS25095	COG3479	Phenolic acid decarboxylase
I5I21_RS25105	COG0747	negative chemotaxis
I5I21_RS25110	COG0601	transmembrane transport
I5I21_RS25115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5I21_RS25125	COG1124	(ABC) transporter
I5I21_RS25135	COG2239	Acts as a magnesium transporter
I5I21_RS25140	COG2081	HI0933 family
I5I21_RS25145	COG0306	phosphate transporter
I5I21_RS25155	COG0589	response to stress
I5I21_RS25175	COG0671	phosphoesterase, PA-phosphatase related
I5I21_RS25180	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I5I21_RS25185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5I21_RS25195	COG1454	alcohol dehydrogenase
I5I21_RS25205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5I21_RS25210	COG1028	Short-chain dehydrogenase reductase Sdr
I5I21_RS25215	COG0583	DNA-binding transcription factor activity
I5I21_RS25220	COG1295	ribonuclease BN
I5I21_RS25225	COG0477	Major facilitator Superfamily
I5I21_RS25230	COG2982	Protein involved in outer membrane biogenesis
I5I21_RS25240	COG0612	Peptidase, M16
I5I21_RS25250	COG2199	diguanylate cyclase activity
I5I21_RS25250	COG2200	EAL domain
I5I21_RS25255	COG0457	Tetratricopeptide repeat
I5I21_RS25255	COG3118	belongs to the thioredoxin family
I5I21_RS25260	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I5I21_RS25265	COG1215	transferase activity, transferring glycosyl groups
I5I21_RS25295	COG2194	sulfuric ester hydrolase activity
I5I21_RS25310	COG0457	Tetratricopeptide repeat
I5I21_RS25315	COG1215	transferase activity, transferring glycosyl groups
I5I21_RS25340	COG4608	Belongs to the ABC transporter superfamily
I5I21_RS25345	COG0444	Belongs to the ABC transporter superfamily
I5I21_RS25350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5I21_RS25355	COG0601	transmembrane transport
I5I21_RS25360	COG0747	negative chemotaxis
I5I21_RS25385	COG2223	nitrite transmembrane transporter activity
I5I21_RS25390	COG5571	outer membrane autotransporter
I5I21_RS25395	COG2818	Glycosylase
I5I21_RS25400	COG0456	acetyltransferase
I5I21_RS25405	COG0243	molybdopterin cofactor binding
I5I21_RS25410	COG2885	chlorophyll binding
I5I21_RS25415	COG1609	Transcriptional regulator
I5I21_RS25425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5I21_RS25445	COG2814	Major facilitator Superfamily
I5I21_RS25450	COG2944	sequence-specific DNA binding
I5I21_RS25455	COG1278	Cold shock
I5I21_RS25490	COG3274	enterobacterial common antigen metabolic process
I5I21_RS25495	COG4682	membrane
I5I21_RS25500	COG4682	membrane
I5I21_RS25515	COG4213	ABC transporter substrate-binding protein
I5I21_RS25525	COG4214	carbohydrate transport
I5I21_RS25530	COG1609	Transcriptional regulator
I5I21_RS25530	COG2207	Transcriptional regulator
I5I21_RS25535	COG2992	FlgJ-related protein
I5I21_RS25540	COG0366	Alpha amylase catalytic
I5I21_RS25545	COG3977	Valine--pyruvate aminotransferase
I5I21_RS25550	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I5I21_RS25555	COG1414	Transcriptional regulator
I5I21_RS25560	COG3276	selenocysteine insertion sequence binding
I5I21_RS25570	COG0625	glutathione transferase activity
I5I21_RS25575	COG1566	PFAM secretion protein HlyD family protein
I5I21_RS25595	COG3722	fumarate hydratase activity
I5I21_RS25615	COG2186	Transcriptional regulator
I5I21_RS25625	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I5I21_RS25645	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I5I21_RS25650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5I21_RS25660	COG4942	peptidase
I5I21_RS25665	COG2861	carbohydrate metabolic process
I5I21_RS25670	COG0463	Glycosyl transferase, family 2
I5I21_RS25680	COG0156	8-amino-7-oxononanoate synthase activity
I5I21_RS25695	COG0859	PFAM glycosyl transferase family 9
I5I21_RS25720	COG0859	PFAM glycosyl transferase family 9
I5I21_RS25730	COG0438	transferase activity, transferring glycosyl groups
I5I21_RS25735	COG1216	Glycosyl transferase, family 2
I5I21_RS25740	COG1519	Transferase
I5I21_RS25775	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I5I21_RS25800	COG0842	Transport permease protein
I5I21_RS25835	COG1561	YicC-like family, N-terminal region
I5I21_RS25840	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I5I21_RS25845	COG2169	Transcriptional regulator
I5I21_RS25845	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I5I21_RS25855	COG2860	membrane
I5I21_RS25875	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I5I21_RS25880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I5I21_RS25885	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I5I21_RS25890	COG1494	fructose-1,6-bisphosphatase
I5I21_RS25900	COG3152	Membrane
I5I21_RS25925	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I5I21_RS25945	COG0786	glutamate:sodium symporter activity
I5I21_RS25950	COG2233	PERMEase
I5I21_RS25955	COG2982	Protein involved in outer membrane biogenesis
I5I21_RS25960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5I21_RS25960	COG1263	PTS System
I5I21_RS25965	COG1486	melibiose metabolic process
I5I21_RS25975	COG1501	Belongs to the glycosyl hydrolase 31 family
I5I21_RS25980	COG2211	Major facilitator Superfamily
I5I21_RS26010	COG1064	alcohol dehydrogenase
I5I21_RS26020	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I5I21_RS26035	COG1464	Belongs to the NlpA lipoprotein family
I5I21_RS26060	COG0583	DNA-binding transcription factor activity
I5I21_RS26095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5I21_RS26105	COG2814	Major facilitator Superfamily
I5I21_RS26115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5I21_RS26115	COG1263	PTS System
I5I21_RS26120	COG0697	spore germination
I5I21_RS26135	COG2828	Protein conserved in bacteria
I5I21_RS26140	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I5I21_RS26145	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I5I21_RS26150	COG0583	DNA-binding transcription factor activity
I5I21_RS26155	COG3384	dioxygenase
I5I21_RS26165	COG1609	Transcriptional regulator
I5I21_RS26175	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5I21_RS26175	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5I21_RS26180	COG1447	Phosphotransferase system cellobiose-specific component IIA
I5I21_RS26185	COG4580	involved in the transport of maltose and maltodextrins
I5I21_RS26210	COG2188	Transcriptional regulator
I5I21_RS26250	COG2271	Major facilitator Superfamily
I5I21_RS26260	COG2197	response regulator
I5I21_RS26265	COG0440	acetolactate synthase activity
I5I21_RS26270	COG0028	Belongs to the TPP enzyme family
I5I21_RS26300	COG2814	Major facilitator Superfamily
I5I21_RS26305	COG0583	DNA-binding transcription factor activity
I5I21_RS26315	COG2610	gluconate transmembrane transporter activity
I5I21_RS26335	COG2149	membrane
I5I21_RS26350	COG2188	Transcriptional regulator
I5I21_RS26360	COG3645	SOS response
I5I21_RS26375	COG5645	(Lipo)protein
I5I21_RS26380	COG0823	Involved in the tonB-independent uptake of proteins
I5I21_RS26385	COG2271	Major facilitator Superfamily
I5I21_RS26395	COG0800	Aldolase
I5I21_RS26400	COG3734	2-keto-3-deoxy-galactonokinase
I5I21_RS26405	COG2186	Transcriptional regulator
I5I21_RS26420	COG0561	phosphatase activity
I5I21_RS26425	COG0187	DNA topoisomerase II activity
I5I21_RS26470	COG0697	spore germination
I5I21_RS26510	COG3344	reverse transcriptase
I5I21_RS26615	COG0840	transmembrane signaling receptor activity
I5I21_RS26640	COG3173	Aminoglycoside phosphotransferase
I5I21_RS26885	COG3344	reverse transcriptase
I5I21_RS26920	COG3436	PFAM IS66 Orf2 family protein
I5I21_RS26925	COG4372	Transposase
I5I21_RS26955	COG1216	Glycosyl transferase, family 2
I5I21_RS26995	COG3188	usher protein
I5I21_RS27005	COG2200	EAL domain
I5I21_RS27015	COG2135	peptidase activity
I5I21_RS27075	COG2433	Pfam Transposase IS66
I5I21_RS27080	COG3436	PFAM IS66 Orf2 family protein
I5I21_RS27205	COG1192	Involved in chromosome partitioning
I5I21_RS27210	COG1192	Involved in chromosome partitioning
I5I21_RS27250	COG0484	heat shock protein binding
I5I21_RS27360	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
I5I21_RS27390	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I5I21_RS27395	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I5I21_RS27470	COG2826	transposase and inactivated derivatives, IS30 family
I5I21_RS27475	COG3039	Transposase
I5I21_RS27495	COG0673	inositol 2-dehydrogenase activity