locus-tag	class	description
A4U70_RS00025	COG0187	DNA topoisomerase II activity
A4U70_RS00030	COG0561	phosphatase activity
A4U70_RS00045	COG2186	Transcriptional regulator
A4U70_RS00050	COG3734	2-keto-3-deoxy-galactonokinase
A4U70_RS00055	COG0800	Aldolase
A4U70_RS00065	COG2271	Major facilitator Superfamily
A4U70_RS00070	COG0823	Involved in the tonB-independent uptake of proteins
A4U70_RS00075	COG5645	(Lipo)protein
A4U70_RS00100	COG2188	Transcriptional regulator
A4U70_RS00115	COG2149	membrane
A4U70_RS00135	COG2610	gluconate transmembrane transporter activity
A4U70_RS00140	COG0583	DNA-binding transcription factor activity
A4U70_RS00145	COG2814	Major facilitator Superfamily
A4U70_RS00170	COG0028	Belongs to the TPP enzyme family
A4U70_RS00175	COG0440	acetolactate synthase activity
A4U70_RS00180	COG2197	response regulator
A4U70_RS00190	COG2271	Major facilitator Superfamily
A4U70_RS00230	COG2188	Transcriptional regulator
A4U70_RS00255	COG4580	involved in the transport of maltose and maltodextrins
A4U70_RS00260	COG1447	Phosphotransferase system cellobiose-specific component IIA
A4U70_RS00265	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A4U70_RS00265	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A4U70_RS00275	COG1609	Transcriptional regulator
A4U70_RS00285	COG3384	dioxygenase
A4U70_RS00290	COG0583	DNA-binding transcription factor activity
A4U70_RS00295	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A4U70_RS00300	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A4U70_RS00305	COG2828	Protein conserved in bacteria
A4U70_RS00320	COG0697	spore germination
A4U70_RS00325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4U70_RS00325	COG1263	PTS System
A4U70_RS00335	COG2814	Major facilitator Superfamily
A4U70_RS00345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4U70_RS00380	COG0583	DNA-binding transcription factor activity
A4U70_RS00405	COG1464	Belongs to the NlpA lipoprotein family
A4U70_RS00420	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A4U70_RS00430	COG1064	alcohol dehydrogenase
A4U70_RS00460	COG2211	Major facilitator Superfamily
A4U70_RS00465	COG1501	Belongs to the glycosyl hydrolase 31 family
A4U70_RS00475	COG1486	melibiose metabolic process
A4U70_RS00480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4U70_RS00480	COG1263	PTS System
A4U70_RS00485	COG2982	Protein involved in outer membrane biogenesis
A4U70_RS00490	COG2233	PERMEase
A4U70_RS00495	COG0786	glutamate:sodium symporter activity
A4U70_RS00510	COG3074	FtsZ-dependent cytokinesis
A4U70_RS00515	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
A4U70_RS00540	COG3152	Membrane
A4U70_RS00550	COG1494	fructose-1,6-bisphosphatase
A4U70_RS00555	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A4U70_RS00560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4U70_RS00565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A4U70_RS00585	COG2860	membrane
A4U70_RS00595	COG2169	Transcriptional regulator
A4U70_RS00595	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A4U70_RS00600	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A4U70_RS00605	COG1561	YicC-like family, N-terminal region
A4U70_RS00625	COG1131	(ABC) transporter
A4U70_RS00630	COG0842	Transport permease protein
A4U70_RS00655	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A4U70_RS00690	COG1519	Transferase
A4U70_RS00695	COG1216	Glycosyl transferase, family 2
A4U70_RS00700	COG0438	transferase activity, transferring glycosyl groups
A4U70_RS00710	COG0859	PFAM glycosyl transferase family 9
A4U70_RS00735	COG0859	PFAM glycosyl transferase family 9
A4U70_RS00750	COG0156	8-amino-7-oxononanoate synthase activity
A4U70_RS00760	COG0463	Glycosyl transferase, family 2
A4U70_RS00765	COG2861	carbohydrate metabolic process
A4U70_RS00770	COG4942	peptidase
A4U70_RS00780	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A4U70_RS00785	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A4U70_RS00805	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A4U70_RS00815	COG2186	Transcriptional regulator
A4U70_RS00835	COG3722	fumarate hydratase activity
A4U70_RS00850	COG0625	glutathione transferase activity
A4U70_RS00860	COG3276	selenocysteine insertion sequence binding
A4U70_RS00865	COG1414	Transcriptional regulator
A4U70_RS00870	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4U70_RS00875	COG3977	Valine--pyruvate aminotransferase
A4U70_RS00880	COG0366	Alpha amylase catalytic
A4U70_RS00890	COG2992	FlgJ-related protein
A4U70_RS00895	COG1609	Transcriptional regulator
A4U70_RS00895	COG2207	Transcriptional regulator
A4U70_RS00900	COG4214	carbohydrate transport
A4U70_RS00910	COG4213	ABC transporter substrate-binding protein
A4U70_RS00930	COG4682	membrane
A4U70_RS00935	COG4682	membrane
A4U70_RS00940	COG3274	enterobacterial common antigen metabolic process
A4U70_RS00975	COG0488	(ABC) transporter
A4U70_RS00980	COG1278	Cold shock
A4U70_RS00985	COG2944	sequence-specific DNA binding
A4U70_RS00990	COG2814	Major facilitator Superfamily
A4U70_RS01010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4U70_RS01020	COG1609	Transcriptional regulator
A4U70_RS01025	COG2885	chlorophyll binding
A4U70_RS01030	COG0243	molybdopterin cofactor binding
A4U70_RS01035	COG0456	acetyltransferase
A4U70_RS01040	COG2818	Glycosylase
A4U70_RS01045	COG5571	outer membrane autotransporter
A4U70_RS01050	COG2223	nitrite transmembrane transporter activity
A4U70_RS01090	COG0747	negative chemotaxis
A4U70_RS01095	COG0601	transmembrane transport
A4U70_RS01100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4U70_RS01105	COG0444	Belongs to the ABC transporter superfamily
A4U70_RS01110	COG4608	Belongs to the ABC transporter superfamily
A4U70_RS01125	COG2894	cell division
A4U70_RS01135	COG1215	transferase activity, transferring glycosyl groups
A4U70_RS01140	COG0457	Tetratricopeptide repeat
A4U70_RS01155	COG2194	sulfuric ester hydrolase activity
A4U70_RS01195	COG1215	transferase activity, transferring glycosyl groups
A4U70_RS01200	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
A4U70_RS01205	COG3118	belongs to the thioredoxin family
A4U70_RS01205	COG0457	Tetratricopeptide repeat
A4U70_RS01210	COG2200	EAL domain
A4U70_RS01210	COG2199	diguanylate cyclase activity
A4U70_RS01220	COG0612	Peptidase, M16
A4U70_RS01235	COG2982	Protein involved in outer membrane biogenesis
A4U70_RS01240	COG0477	Major facilitator Superfamily
A4U70_RS01245	COG1295	ribonuclease BN
A4U70_RS01250	COG0583	DNA-binding transcription factor activity
A4U70_RS01255	COG1028	Short-chain dehydrogenase reductase Sdr
A4U70_RS01260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4U70_RS01270	COG1454	alcohol dehydrogenase
A4U70_RS01280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4U70_RS01285	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A4U70_RS01290	COG0671	phosphoesterase, PA-phosphatase related
A4U70_RS01310	COG0589	response to stress
A4U70_RS01320	COG0306	phosphate transporter
A4U70_RS01325	COG2081	HI0933 family
A4U70_RS01330	COG2239	Acts as a magnesium transporter
A4U70_RS01340	COG1124	(ABC) transporter
A4U70_RS01350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4U70_RS01355	COG0601	transmembrane transport
A4U70_RS01360	COG0747	negative chemotaxis
A4U70_RS01370	COG3479	Phenolic acid decarboxylase
A4U70_RS01410	COG0628	permease
A4U70_RS01415	COG0477	Major facilitator Superfamily
A4U70_RS01425	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A4U70_RS01440	COG3714	YhhN family
A4U70_RS01450	COG3776	membrane
A4U70_RS01455	COG0742	ribosomal rna small subunit methyltransferase
A4U70_RS01460	COG0552	protein localization to endoplasmic reticulum
A4U70_RS01465	COG2884	Cell division ATP-binding protein ftsE
A4U70_RS01470	COG2177	Part of the ABC transporter FtsEX involved in
A4U70_RS01485	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A4U70_RS01495	COG0683	leucine binding
A4U70_RS01505	COG0683	leucine binding
A4U70_RS01510	COG0559	Belongs to the binding-protein-dependent transport system permease family
A4U70_RS01560	COG0584	glycerophosphoryl diester phosphodiesterase
A4U70_RS01570	COG0405	Gamma-glutamyltransferase
A4U70_RS01575	COG1247	-acetyltransferase
A4U70_RS01590	COG0673	inositol 2-dehydrogenase activity
A4U70_RS01595	COG1741	Belongs to the pirin family
A4U70_RS01600	COG1609	Transcriptional regulator
A4U70_RS01605	COG3265	gluconokinase activity
A4U70_RS01610	COG2610	gluconate transmembrane transporter activity
A4U70_RS01620	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A4U70_RS01645	COG0058	SHG alpha-glucan phosphorylase activity
A4U70_RS01660	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A4U70_RS01675	COG1349	DNA-binding transcription factor activity
A4U70_RS01690	COG0058	SHG alpha-glucan phosphorylase activity
A4U70_RS01695	COG1640	4-alpha-glucanotransferase
A4U70_RS01700	COG2610	gluconate transmembrane transporter activity
A4U70_RS01710	COG1040	competence protein
A4U70_RS01735	COG1918	ferrous iron import across plasma membrane
A4U70_RS01740	COG2183	response to ionizing radiation
A4U70_RS01745	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A4U70_RS01770	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A4U70_RS01775	COG1011	Hydrolase
A4U70_RS01785	COG0494	nUDIX hydrolase
A4U70_RS01790	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A4U70_RS01815	COG4796	Type ii and iii secretion system protein
A4U70_RS01835	COG3266	domain, Protein
A4U70_RS01840	COG0338	D12 class N6 adenine-specific DNA methyltransferase
A4U70_RS01845	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A4U70_RS01870	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A4U70_RS01875	COG0402	S-adenosylhomocysteine deaminase activity
A4U70_RS01880	COG0738	Major facilitator superfamily
A4U70_RS01905	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A4U70_RS01910	COG1289	transmembrane transporter activity
A4U70_RS01925	COG1765	OsmC-like protein
A4U70_RS01930	COG3954	Phosphoribulokinase
A4U70_RS01940	COG0429	hydrolase of the alpha beta-hydrolase fold
A4U70_RS01950	COG0488	(ABC) transporter
A4U70_RS01965	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
A4U70_RS01970	COG1047	Peptidyl-prolyl cis-trans
A4U70_RS01980	COG0545	Peptidyl-prolyl cis-trans isomerase
A4U70_RS01985	COG2964	Protein conserved in bacteria
A4U70_RS02040	COG0051	transcription antitermination factor activity, RNA binding
A4U70_RS02065	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A4U70_RS02080	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A4U70_RS02145	COG0201	protein transport
A4U70_RS02170	COG0202	RNA polymerase activity
A4U70_RS02185	COG0789	Transcriptional regulator
A4U70_RS02190	COG3036	rescue of stalled ribosome
A4U70_RS02220	COG0758	DNA mediated transformation
A4U70_RS02230	COG0551	DNA topoisomerase type I activity
A4U70_RS02250	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A4U70_RS02285	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4U70_RS02290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4U70_RS02295	COG1309	transcriptional regulator
A4U70_RS02320	COG4145	pantothenate transmembrane transporter activity
A4U70_RS02325	COG3924	membrane
A4U70_RS02330	COG0439	Biotin carboxylase
A4U70_RS02335	COG0511	ligase activity, forming carbon-carbon bonds
A4U70_RS02365	COG2200	EAL domain
A4U70_RS02365	COG2199	diguanylate cyclase activity
A4U70_RS02375	COG1077	Cell shape determining protein MreB Mrl
A4U70_RS02380	COG1792	Involved in formation and maintenance of cell shape
A4U70_RS02385	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A4U70_RS02395	COG1530	ribonuclease E activity
A4U70_RS02400	COG3164	Protein of unknown function
A4U70_RS02405	COG0312	modulator of DNA gyrase
A4U70_RS02410	COG0583	DNA-binding transcription factor activity
A4U70_RS02425	COG1289	transmembrane transporter activity
A4U70_RS02430	COG2732	(Barnase) inhibitor
A4U70_RS02455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4U70_RS02460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4U70_RS02465	COG3105	Protein conserved in bacteria
A4U70_RS02470	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A4U70_RS02490	COG0625	glutathione transferase activity
A4U70_RS02495	COG2969	positive regulation of protein catabolic process
A4U70_RS02505	COG0493	'glutamate synthase
A4U70_RS02520	COG1242	4 iron, 4 sulfur cluster binding
A4U70_RS02525	COG2271	Major facilitator Superfamily
A4U70_RS02530	COG1063	alcohol dehydrogenase
A4U70_RS02535	COG1312	Catalyzes the dehydration of D-mannonate
A4U70_RS02540	COG0784	Response regulator, receiver
A4U70_RS02540	COG5002	protein histidine kinase activity
A4U70_RS02540	COG2198	Histidine kinase
A4U70_RS02545	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
A4U70_RS02550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A4U70_RS02555	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4U70_RS02565	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4U70_RS02570	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A4U70_RS02575	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A4U70_RS02580	COG1137	ATPase activity
A4U70_RS02585	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A4U70_RS02590	COG3117	lipopolysaccharide transmembrane transporter activity
A4U70_RS02595	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A4U70_RS02605	COG0530	calcium, potassium:sodium antiporter activity
A4U70_RS02615	COG1127	ABC transporter
A4U70_RS02620	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A4U70_RS02625	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A4U70_RS02630	COG2854	intermembrane phospholipid transfer
A4U70_RS02635	COG3113	response to antibiotic
A4U70_RS02640	COG5007	Belongs to the BolA IbaG family
A4U70_RS02650	COG3423	Transcriptional regulator
A4U70_RS02655	COG0142	geranyltranstransferase activity
A4U70_RS02670	COG0697	spore germination
A4U70_RS02680	COG2027	D-alanyl-D-alanine carboxypeptidase
A4U70_RS02690	COG1534	Rna-binding protein
A4U70_RS02705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4U70_RS02710	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A4U70_RS02720	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A4U70_RS02760	COG0195	Participates in both transcription termination and antitermination
A4U70_RS02805	COG0814	amino acid
A4U70_RS02810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4U70_RS02815	COG0826	peptidase U32
A4U70_RS02820	COG0826	peptidase U32
A4U70_RS02825	COG3154	lipid carrier protein
A4U70_RS02830	COG3153	acetyltransferase
A4U70_RS02845	COG0693	protein deglycase activity
A4U70_RS02850	COG0702	epimerase
A4U70_RS02855	COG0701	Predicted permease
A4U70_RS02860	COG2823	Periplasmic or secreted lipoprotein
A4U70_RS02880	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A4U70_RS02885	COG2721	sulfolactate sulfo-lyase activity
A4U70_RS02890	COG2271	Major facilitator Superfamily
A4U70_RS02900	COG2084	Dehydrogenase
A4U70_RS02905	COG1929	Belongs to the glycerate kinase type-1 family
A4U70_RS02925	COG1741	Belongs to the pirin family
A4U70_RS02930	COG0583	DNA-binding transcription factor activity
A4U70_RS02935	COG3152	Membrane
A4U70_RS02940	COG0435	Glutathione S-transferase
A4U70_RS02945	COG2259	Doxx family
A4U70_RS02955	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
A4U70_RS02960	COG4575	ribosome binding
A4U70_RS02965	COG1422	Protein of unknown function (DUF1090)
A4U70_RS02975	COG0586	Pfam SNARE associated Golgi protein
A4U70_RS02980	COG2186	Transcriptional regulator
A4U70_RS02985	COG2271	Major facilitator Superfamily
A4U70_RS02995	COG2721	sulfolactate sulfo-lyase activity
A4U70_RS03010	COG0861	Integral membrane protein TerC family
A4U70_RS03015	COG0673	inositol 2-dehydrogenase activity
A4U70_RS03020	COG1451	nucleotide metabolic process
A4U70_RS03040	COG1902	pentaerythritol trinitrate reductase activity
A4U70_RS03040	COG0446	pyridine nucleotide-disulphide oxidoreductase
A4U70_RS03095	COG1695	Transcriptional regulator
A4U70_RS03100	COG2375	cellular response to nickel ion
A4U70_RS03115	COG1461	Dihydroxyacetone kinase
A4U70_RS03120	COG2376	Dihydroxyacetone kinase
A4U70_RS03195	COG3247	response to pH
A4U70_RS03205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4U70_RS03205	COG2198	Histidine kinase
A4U70_RS03205	COG0784	Response regulator, receiver
A4U70_RS03205	COG2205	protein histidine kinase activity
A4U70_RS03210	COG2197	response regulator
A4U70_RS03235	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A4U70_RS03240	COG0358	DNA primase activity
A4U70_RS03245	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A4U70_RS03310	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A4U70_RS03325	COG4991	sh3 domain protein
A4U70_RS03330	COG3025	triphosphatase activity
A4U70_RS03350	COG2960	long-chain fatty acid transporting porin activity
A4U70_RS03365	COG3384	dioxygenase
A4U70_RS03370	COG0754	glutathionylspermidine amidase activity
A4U70_RS03385	COG0494	nUDIX hydrolase
A4U70_RS03390	COG3151	Protein conserved in bacteria
A4U70_RS03395	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A4U70_RS03400	COG3150	esterase
A4U70_RS03410	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
A4U70_RS03415	COG2249	NAD(P)H dehydrogenase (quinone) activity
A4U70_RS03420	COG0642	Histidine kinase
A4U70_RS03430	COG3111	PFAM Bacterial OB fold (BOF) protein
A4U70_RS03435	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
A4U70_RS03440	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A4U70_RS03445	COG0204	Acyl-transferase
A4U70_RS03450	COG2132	Multicopper oxidase
A4U70_RS03455	COG1032	radical SAM domain protein
A4U70_RS03465	COG0656	L-ascorbic acid biosynthetic process
A4U70_RS03470	COG1979	alcohol dehydrogenase
A4U70_RS03475	COG2207	Transcriptional regulator
A4U70_RS03480	COG0586	Pfam SNARE associated Golgi protein
A4U70_RS03485	COG0626	cystathionine gamma-synthase activity
A4U70_RS03500	COG0848	biopolymer transport protein
A4U70_RS03505	COG2211	Major facilitator Superfamily
A4U70_RS03530	COG0625	glutathione transferase activity
A4U70_RS03540	COG0754	glutathionylspermidine amidase activity
A4U70_RS03545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4U70_RS03565	COG0583	DNA-binding transcription factor activity
A4U70_RS03570	COG0626	cystathionine gamma-synthase activity
A4U70_RS03585	COG3121	Chaperone
A4U70_RS03600	COG3121	Chaperone
A4U70_RS03605	COG3121	Chaperone
A4U70_RS03610	COG3188	usher protein
A4U70_RS03640	COG1811	Na channel or pump
A4U70_RS03650	COG1982	Orn Lys Arg decarboxylase major
A4U70_RS03655	COG2211	Major facilitator Superfamily
A4U70_RS03670	COG1194	a g-specific adenine glycosylase
A4U70_RS03680	COG3171	Protein conserved in bacteria
A4U70_RS03690	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A4U70_RS03705	COG0762	integral membrane protein
A4U70_RS03710	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A4U70_RS03715	COG2805	Type II/IV secretion system protein
A4U70_RS03735	COG0189	ligase activity
A4U70_RS03740	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A4U70_RS03745	COG2356	endonuclease I
A4U70_RS03755	COG2814	Major facilitator Superfamily
A4U70_RS03795	COG2146	nitrite reductase [NAD(P)H] activity
A4U70_RS03810	COG1028	Short-chain dehydrogenase reductase Sdr
A4U70_RS03815	COG1414	Transcriptional regulator
A4U70_RS03840	COG2267	carboxylic ester hydrolase activity
A4U70_RS03845	COG1028	Short-chain dehydrogenase reductase Sdr
A4U70_RS03850	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
A4U70_RS03870	COG0501	Belongs to the peptidase M48B family
A4U70_RS03875	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A4U70_RS03890	COG0191	fructose-bisphosphate aldolase activity
A4U70_RS03895	COG0668	transmembrane transport
A4U70_RS03905	COG2968	Membrane
A4U70_RS03920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4U70_RS03925	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A4U70_RS03945	COG0006	proline dipeptidase activity
A4U70_RS03950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4U70_RS03955	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4U70_RS03975	COG1028	Short-chain dehydrogenase reductase Sdr
A4U70_RS03985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4U70_RS04005	COG2723	6-phospho-beta-galactosidase activity
A4U70_RS04010	COG1737	Transcriptional regulator
A4U70_RS04020	COG1272	protein, Hemolysin III
A4U70_RS04030	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A4U70_RS04040	COG0716	FMN binding
A4U70_RS04045	COG4974	Belongs to the 'phage' integrase family
A4U70_RS04055	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A4U70_RS04080	COG4942	peptidase
A4U70_RS04090	COG2814	Major facilitator Superfamily
A4U70_RS04110	COG2197	response regulator
A4U70_RS04120	COG2205	protein histidine kinase activity
A4U70_RS04120	COG2198	Histidine kinase
A4U70_RS04120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4U70_RS04120	COG0784	Response regulator, receiver
A4U70_RS04125	COG2197	response regulator
A4U70_RS04155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4U70_RS04160	COG0601	transmembrane transport
A4U70_RS04170	COG4413	Urea transporter
A4U70_RS04180	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A4U70_RS04200	COG0832	Belongs to the urease beta subunit family
A4U70_RS04205	COG0831	urea catabolic process
A4U70_RS04210	COG0004	ammonium transporteR
A4U70_RS04225	COG0477	Major facilitator Superfamily
A4U70_RS04230	COG1566	PFAM secretion protein HlyD family protein
A4U70_RS04235	COG2197	response regulator
A4U70_RS04240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4U70_RS04240	COG2198	Histidine kinase
A4U70_RS04240	COG0784	Response regulator, receiver
A4U70_RS04240	COG2205	protein histidine kinase activity
A4U70_RS04260	COG2200	EAL domain
A4U70_RS04275	COG0667	Aldo Keto reductase
A4U70_RS04310	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A4U70_RS04315	COG1393	Belongs to the ArsC family
A4U70_RS04330	COG1538	Outer membrane efflux protein
A4U70_RS04335	COG1289	transmembrane transporter activity
A4U70_RS04350	COG3592	Divergent 4Fe-4S mono-cluster
A4U70_RS04355	COG2388	GCN5-related N-acetyl-transferase
A4U70_RS04365	COG3539	Fimbrial protein
A4U70_RS04370	COG3539	Fimbrial protein
A4U70_RS04375	COG3539	Fimbrial protein
A4U70_RS04380	COG3188	usher protein
A4U70_RS04385	COG3121	Chaperone
A4U70_RS04390	COG3539	Fimbrial protein
A4U70_RS04400	COG4974	Belongs to the 'phage' integrase family
A4U70_RS04405	COG0582	viral genome integration into host DNA
A4U70_RS04420	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
A4U70_RS04425	COG1846	Transcriptional regulator
A4U70_RS04430	COG0697	spore germination
A4U70_RS04480	COG0667	Aldo Keto reductase
A4U70_RS04485	COG0814	amino acid
A4U70_RS04500	COG0183	Belongs to the thiolase family
A4U70_RS04515	COG1028	Short-chain dehydrogenase reductase Sdr
A4U70_RS04520	COG2814	Major facilitator Superfamily
A4U70_RS04550	COG3842	ATPase activity
A4U70_RS04555	COG0395	ABC-type sugar transport system, permease component
A4U70_RS04560	COG1175	transmembrane transport
A4U70_RS04565	COG1917	Cupin 2, conserved barrel domain protein
A4U70_RS04570	COG1794	racemase activity, acting on amino acids and derivatives
A4U70_RS04575	COG0583	DNA-binding transcription factor activity
A4U70_RS04585	COG1609	Transcriptional regulator
A4U70_RS04590	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A4U70_RS04595	COG2723	6-phospho-beta-galactosidase activity
A4U70_RS04600	COG2186	Transcriptional regulator
A4U70_RS04610	COG1609	Transcriptional regulator
A4U70_RS04635	COG0667	Aldo Keto reductase
A4U70_RS04645	COG0861	Integral membrane protein TerC family
A4U70_RS04675	COG2165	general secretion pathway protein
A4U70_RS04680	COG4795	General secretion pathway protein
A4U70_RS04690	COG4967	type IV pilus modification protein PilV
A4U70_RS04695	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A4U70_RS04700	COG1025	Belongs to the peptidase M16 family
A4U70_RS04705	COG1074	ATP-dependent DNA helicase activity
A4U70_RS04710	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4U70_RS04720	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A4U70_RS04720	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A4U70_RS04725	COG0860	N-Acetylmuramoyl-L-alanine amidase
A4U70_RS04730	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A4U70_RS04760	COG4656	Part of a membrane complex involved in electron transport
A4U70_RS04765	COG1454	alcohol dehydrogenase
A4U70_RS04765	COG1012	belongs to the aldehyde dehydrogenase family
A4U70_RS04795	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
A4U70_RS04960	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
A4U70_RS04965	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A4U70_RS04970	COG2166	iron-sulfur cluster assembly
A4U70_RS04975	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A4U70_RS04985	COG0583	DNA-binding transcription factor activity
A4U70_RS04990	COG2363	Small membrane protein
A4U70_RS05020	COG0738	Major facilitator superfamily
A4U70_RS05025	COG0235	Class ii aldolase
A4U70_RS05030	COG1454	alcohol dehydrogenase
A4U70_RS05045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4U70_RS05065	COG2011	ABC-type metal ion transport system permease component
A4U70_RS05070	COG1464	Belongs to the NlpA lipoprotein family
A4U70_RS05080	COG0477	Major facilitator Superfamily
A4U70_RS05090	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A4U70_RS05095	COG1760	l-serine dehydratase
A4U70_RS05100	COG0814	amino acid
A4U70_RS05105	COG1611	Belongs to the LOG family
A4U70_RS05120	COG3098	single-species biofilm formation
A4U70_RS05125	COG0564	pseudouridine synthase activity
A4U70_RS05130	COG0716	FMN binding
A4U70_RS05135	COG2271	Major facilitator Superfamily
A4U70_RS05140	COG4948	Mandelate Racemase Muconate Lactonizing
A4U70_RS05145	COG4948	Mandelate Racemase Muconate Lactonizing
A4U70_RS05150	COG1929	Belongs to the glycerate kinase type-1 family
A4U70_RS05155	COG2205	protein histidine kinase activity
A4U70_RS05155	COG4999	Histidine kinase
A4U70_RS05155	COG3850	Histidine kinase
A4U70_RS05155	COG3437	response regulator, receiver
A4U70_RS05165	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A4U70_RS05170	COG3956	TIGRFAM MazG family protein
A4U70_RS05190	COG0602	queuosine metabolic process
A4U70_RS05195	COG0720	synthase
A4U70_RS05215	COG2234	aminopeptidase activity
A4U70_RS05275	COG1388	LysM domain
A4U70_RS05275	COG4942	peptidase
A4U70_RS05305	COG0163	prenyltransferase activity
A4U70_RS05310	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A4U70_RS05350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4U70_RS05355	COG4558	Periplasmic binding protein
A4U70_RS05360	COG3720	iron ion transport
A4U70_RS05380	COG0679	Auxin Efflux Carrier
A4U70_RS05395	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A4U70_RS05400	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A4U70_RS05405	COG1121	(ABC) transporter
A4U70_RS05410	COG0803	Belongs to the bacterial solute-binding protein 9 family
A4U70_RS05415	COG1609	Transcriptional regulator
A4U70_RS05420	COG1940	carbohydrate kinase activity
A4U70_RS05425	COG1447	Phosphotransferase system cellobiose-specific component IIA
A4U70_RS05430	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A4U70_RS05435	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A4U70_RS05440	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A4U70_RS05445	COG4580	involved in the transport of maltose and maltodextrins
A4U70_RS05455	COG2723	6-phospho-beta-galactosidase activity
A4U70_RS05465	COG0309	Hydrogenase expression formation protein (HypE)
A4U70_RS05470	COG0409	Hydrogenase expression formation protein
A4U70_RS05475	COG0298	carbon dioxide binding
A4U70_RS05480	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A4U70_RS05500	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4U70_RS05505	COG0651	ATP synthesis coupled electron transport
A4U70_RS05510	COG0650	Formate hydrogenlyase subunit 4
A4U70_RS05515	COG3261	NADH dehydrogenase
A4U70_RS05515	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
A4U70_RS05520	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4U70_RS05525	COG3260	NADH ubiquinone oxidoreductase 20
A4U70_RS05535	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
A4U70_RS05545	COG2723	6-phospho-beta-galactosidase activity
A4U70_RS05550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4U70_RS05550	COG1263	PTS System
A4U70_RS05555	COG1609	Transcriptional regulator
A4U70_RS05560	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4U70_RS05565	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
A4U70_RS05570	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
A4U70_RS05600	COG1349	DNA-binding transcription factor activity
A4U70_RS05605	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4U70_RS05610	COG1028	Short-chain dehydrogenase reductase Sdr
A4U70_RS05620	COG3732	PTS system glucitol sorbitol-specific
A4U70_RS05625	COG3730	PTS system glucitol sorbitol-specific
A4U70_RS05630	COG2951	lytic endotransglycosylase activity
A4U70_RS05640	COG1121	(ABC) transporter
A4U70_RS05645	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A4U70_RS05655	COG1546	Belongs to the CinA family
A4U70_RS05680	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A4U70_RS05710	COG2823	Periplasmic or secreted lipoprotein
A4U70_RS05715	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4U70_RS05720	COG1238	metal cluster binding
A4U70_RS05740	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A4U70_RS05745	COG2814	Major facilitator Superfamily
A4U70_RS05750	COG1566	PFAM secretion protein HlyD family protein
A4U70_RS05755	COG1846	Transcriptional regulator
A4U70_RS05765	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A4U70_RS05775	COG4176	ABC-type proline glycine betaine transport system permease component
A4U70_RS05790	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4U70_RS05800	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A4U70_RS05805	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A4U70_RS05810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4U70_RS05815	COG4575	ribosome binding
A4U70_RS05835	COG2916	Histone family protein nucleoid-structuring protein H-NS
A4U70_RS05850	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A4U70_RS05855	COG0640	Transcriptional regulator
A4U70_RS05865	COG0583	DNA-binding transcription factor activity
A4U70_RS05870	COG3284	Transcriptional regulator
A4U70_RS05880	COG3539	Fimbrial protein
A4U70_RS05885	COG3121	Chaperone
A4U70_RS05905	COG3188	usher protein
A4U70_RS05915	COG3539	Fimbrial protein
A4U70_RS05920	COG2197	response regulator
A4U70_RS05935	COG1028	Short-chain dehydrogenase reductase Sdr
A4U70_RS05945	COG0235	Class ii aldolase
A4U70_RS05955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4U70_RS05990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4U70_RS05995	COG2207	Transcriptional regulator
A4U70_RS05995	COG3708	Transcriptional regulator
A4U70_RS06025	COG2867	negative regulation of translational initiation
A4U70_RS06040	COG0497	DNA recombination
A4U70_RS06060	COG4536	flavin adenine dinucleotide binding
A4U70_RS06065	COG4137	Cytochrome C assembly protein
A4U70_RS06070	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A4U70_RS06105	COG2885	chlorophyll binding
A4U70_RS06110	COG2199	diguanylate cyclase activity
A4U70_RS06120	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A4U70_RS06125	COG1605	Chorismate mutase
A4U70_RS06125	COG0287	Prephenate dehydrogenase
A4U70_RS06135	COG1605	Chorismate mutase
A4U70_RS06135	COG0077	Prephenate dehydratase
A4U70_RS06140	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A4U70_RS06145	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A4U70_RS06160	COG0542	response to heat
A4U70_RS06185	COG0477	Major facilitator Superfamily
A4U70_RS06190	COG5544	Lipoprotein
A4U70_RS06195	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A4U70_RS06205	COG3148	PFAM DTW domain containing protein
A4U70_RS06210	COG3118	belongs to the thioredoxin family
A4U70_RS06215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4U70_RS06230	COG0513	Belongs to the DEAD box helicase family
A4U70_RS06240	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A4U70_RS06250	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
A4U70_RS06255	COG3026	antisigma factor binding
A4U70_RS06260	COG3086	response to oxidative stress
A4U70_RS06270	COG0681	Belongs to the peptidase S26 family
A4U70_RS06290	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A4U70_RS06300	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4U70_RS06305	COG1737	Transcriptional regulator
A4U70_RS06310	COG0560	Phosphoserine phosphatase
A4U70_RS06325	COG0047	phosphoribosylformylglycinamidine synthase activity
A4U70_RS06325	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A4U70_RS06330	COG2205	protein histidine kinase activity
A4U70_RS06335	COG3170	Tfp pilus assembly protein FimV
A4U70_RS06340	COG2204	response regulator
A4U70_RS06345	COG0347	Belongs to the P(II) protein family
A4U70_RS06350	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A4U70_RS06350	COG1017	nitric oxide dioxygenase activity
A4U70_RS06365	COG2259	Doxx family
A4U70_RS06370	COG1940	carbohydrate kinase activity
A4U70_RS06375	COG0457	Tetratricopeptide repeat
A4U70_RS06380	COG0477	Major facilitator Superfamily
A4U70_RS06380	COG2814	Major facilitator Superfamily
A4U70_RS06385	COG2017	converts alpha-aldose to the beta-anomer
A4U70_RS06390	COG2814	Major facilitator Superfamily
A4U70_RS06395	COG3711	transcriptional antiterminator
A4U70_RS06400	COG3683	transport system, periplasmic component
A4U70_RS06405	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
A4U70_RS06435	COG0822	iron-sulfur transferase activity
A4U70_RS06455	COG0633	Ferredoxin
A4U70_RS06460	COG2975	iron-sulfur cluster assembly
A4U70_RS06480	COG2897	thiosulfate sulfurtransferase activity
A4U70_RS06490	COG4953	penicillin-binding protein 1C
A4U70_RS06520	COG2976	Protein conserved in bacteria
A4U70_RS06640	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A4U70_RS06640	COG0758	DNA mediated transformation
A4U70_RS06665	COG1645	bacterial-type flagellum-dependent swarming motility
A4U70_RS06675	COG0517	IMP dehydrogenase activity
A4U70_RS06675	COG0516	GMP reductase activity
A4U70_RS06685	COG3119	arylsulfatase activity
A4U70_RS06690	COG0641	radical SAM
A4U70_RS06710	COG2200	EAL domain
A4U70_RS06725	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A4U70_RS06740	COG2723	6-phospho-beta-galactosidase activity
A4U70_RS06750	COG2233	PERMEase
A4U70_RS06765	COG1393	Belongs to the ArsC family
A4U70_RS06770	COG4783	chaperone-mediated protein folding
A4U70_RS06775	COG0628	permease
A4U70_RS06780	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A4U70_RS06785	COG2716	regulation of RNA biosynthetic process
A4U70_RS06795	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
A4U70_RS06805	COG2321	neutral zinc metallopeptidase
A4U70_RS06810	COG1444	tRNA N-acetyltransferase activity
A4U70_RS06815	COG0400	carboxylic ester hydrolase activity
A4U70_RS06830	COG1393	Belongs to the ArsC family
A4U70_RS06835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4U70_RS06845	COG0493	'glutamate synthase
A4U70_RS06845	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4U70_RS06855	COG5342	invasion associated locus B
A4U70_RS06860	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A4U70_RS06865	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A4U70_RS06875	COG4810	utilization protein
A4U70_RS06965	COG0860	N-Acetylmuramoyl-L-alanine amidase
A4U70_RS06985	COG2837	iron assimilation
A4U70_RS06995	COG4150	thiosulfate binding
A4U70_RS07000	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
A4U70_RS07005	COG4208	sulfate ABC transporter
A4U70_RS07010	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A4U70_RS07020	COG4319	ketosteroid isomerase
A4U70_RS07055	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A4U70_RS07075	COG3530	Putative quorum-sensing-regulated virulence factor
A4U70_RS07080	COG0385	Bile acid
A4U70_RS07085	COG0583	DNA-binding transcription factor activity
A4U70_RS07115	COG3415	Transposase
A4U70_RS07120	COG3415	Transposase
A4U70_RS07135	COG2199	diguanylate cyclase activity
A4U70_RS07135	COG2200	EAL domain
A4U70_RS07140	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A4U70_RS07155	COG0667	Aldo Keto reductase
A4U70_RS07160	COG3961	Belongs to the TPP enzyme family
A4U70_RS07175	COG3279	Response regulator of the LytR AlgR family
A4U70_RS07180	COG3275	phosphorelay sensor kinase activity
A4U70_RS07190	COG0436	Aminotransferase
A4U70_RS07195	COG2807	transmembrane transport
A4U70_RS07200	COG0590	tRNA wobble adenosine to inosine editing
A4U70_RS07205	COG0583	DNA-binding transcription factor activity
A4U70_RS07295	COG0305	Participates in initiation and elongation during chromosome replication
A4U70_RS07375	COG3772	lysozyme
A4U70_RS07385	COG3646	Phage regulatory protein
A4U70_RS07410	COG0494	nUDIX hydrolase
A4U70_RS07520	COG0582	viral genome integration into host DNA
A4U70_RS07535	COG2116	formate transmembrane transporter activity
A4U70_RS07540	COG2853	Lipoprotein
A4U70_RS07550	COG3691	Protein conserved in bacteria
A4U70_RS07565	COG2062	phosphohistidine phosphatase, SixA
A4U70_RS07590	COG0730	response to heat
A4U70_RS07595	COG3101	peptidyl-lysine hydroxylation
A4U70_RS07610	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A4U70_RS07630	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A4U70_RS07640	COG0586	Pfam SNARE associated Golgi protein
A4U70_RS07650	COG0285	dihydrofolate synthase activity
A4U70_RS07655	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
A4U70_RS07660	COG1286	toxin biosynthetic process
A4U70_RS07665	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A4U70_RS07670	COG0163	prenyltransferase activity
A4U70_RS07690	COG4160	amino acid transport
A4U70_RS07695	COG4598	ABC transporter
A4U70_RS07705	COG1090	epimerase
A4U70_RS07710	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A4U70_RS07715	COG0625	glutathione transferase activity
A4U70_RS07720	COG0625	glutathione transferase activity
A4U70_RS07725	COG0622	Phosphoesterase
A4U70_RS07730	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A4U70_RS07735	COG0857	belongs to the CobB CobQ family
A4U70_RS07735	COG0280	phosphate acetyltransferase
A4U70_RS07755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4U70_RS07760	COG0471	metal ion transport
A4U70_RS07760	COG0490	domain, Protein
A4U70_RS07770	COG0436	Aminotransferase
A4U70_RS07775	COG0583	DNA-binding transcription factor activity
A4U70_RS07825	COG0839	Belongs to the complex I subunit 6 family
A4U70_RS07835	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A4U70_RS07840	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4U70_RS07855	COG2153	protein acetylation
A4U70_RS07860	COG1169	isochorismate synthase
A4U70_RS07885	COG0318	PFAM AMP-dependent synthetase and ligase
A4U70_RS07910	COG1414	Transcriptional regulator
A4U70_RS07920	COG2271	Major facilitator Superfamily
A4U70_RS07930	COG0247	lactate metabolic process
A4U70_RS07940	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A4U70_RS07945	COG2271	Major facilitator Superfamily
A4U70_RS07950	COG0584	glycerophosphoryl diester phosphodiesterase
A4U70_RS07960	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A4U70_RS07990	COG2205	protein histidine kinase activity
A4U70_RS07990	COG0784	Response regulator, receiver
A4U70_RS08000	COG2198	Histidine kinase
A4U70_RS08000	COG0642	Histidine kinase
A4U70_RS08015	COG2169	Transcriptional regulator
A4U70_RS08015	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A4U70_RS08020	COG3145	DNA-N1-methyladenine dioxygenase activity
A4U70_RS08025	COG4615	Cyclic peptide transporter
A4U70_RS08030	COG2239	Acts as a magnesium transporter
A4U70_RS08035	COG0659	secondary active sulfate transmembrane transporter activity
A4U70_RS08050	COG0628	permease
A4U70_RS08075	COG1349	DNA-binding transcription factor activity
A4U70_RS08080	COG0494	nUDIX hydrolase
A4U70_RS08100	COG1061	Type III restriction enzyme res subunit
A4U70_RS08105	COG1187	pseudouridine synthase activity
A4U70_RS08110	COG2814	Major facilitator Superfamily
A4U70_RS08120	COG4172	Belongs to the ABC transporter superfamily
A4U70_RS08125	COG4239	(ABC) transporter, permease
A4U70_RS08130	COG4174	ABC transporter (Permease)
A4U70_RS08135	COG4166	transmembrane transport
A4U70_RS08140	COG2200	EAL domain
A4U70_RS08145	COG0791	NLP P60 protein
A4U70_RS08150	COG0671	phosphoesterase, PA-phosphatase related
A4U70_RS08155	COG0523	cobalamin synthesis protein
A4U70_RS08160	COG0246	Mannitol dehydrogenase
A4U70_RS08165	COG1312	Catalyzes the dehydration of D-mannonate
A4U70_RS08185	COG2814	Major facilitator Superfamily
A4U70_RS08195	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4U70_RS08195	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4U70_RS08200	COG1105	Belongs to the carbohydrate kinase PfkB family
A4U70_RS08205	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4U70_RS08205	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
A4U70_RS08205	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4U70_RS08215	COG2855	membrane
A4U70_RS08225	COG0583	DNA-binding transcription factor activity
A4U70_RS08230	COG0833	amino acid
A4U70_RS08240	COG4771	TonB-dependent receptor
A4U70_RS08255	COG2311	Membrane
A4U70_RS08275	COG1129	ABC transporter
A4U70_RS08285	COG2949	membrane
A4U70_RS08295	COG1346	cytolysis
A4U70_RS08305	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A4U70_RS08310	COG3659	wide pore channel activity
A4U70_RS08325	COG2723	6-phospho-beta-galactosidase activity
A4U70_RS08335	COG1538	Outer membrane efflux protein
A4U70_RS08340	COG0586	Pfam SNARE associated Golgi protein
A4U70_RS08350	COG1686	Belongs to the peptidase S11 family
A4U70_RS08360	COG0277	FAD linked oxidase domain protein
A4U70_RS08365	COG1472	Belongs to the glycosyl hydrolase 3 family
A4U70_RS08370	COG1732	Glycine betaine
A4U70_RS08375	COG1174	glycine betaine transport
A4U70_RS08380	COG1125	glycine betaine transport
A4U70_RS08385	COG1174	glycine betaine transport
A4U70_RS08395	COG3275	phosphorelay sensor kinase activity
A4U70_RS08405	COG4807	Protein conserved in bacteria
A4U70_RS08425	COG5455	response to cobalt ion
A4U70_RS08430	COG0583	DNA-binding transcription factor activity
A4U70_RS08435	COG2252	PERMEase
A4U70_RS08445	COG0583	DNA-binding transcription factor activity
A4U70_RS08460	COG0351	phosphomethylpyrimidine kinase
A4U70_RS08465	COG1830	Aldolase
A4U70_RS08500	COG1070	Carbohydrate kinase
A4U70_RS08510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4U70_RS08515	COG4948	Mandelate Racemase Muconate Lactonizing
A4U70_RS08520	COG0747	negative chemotaxis
A4U70_RS08525	COG0601	transmembrane transport
A4U70_RS08530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4U70_RS08535	COG0444	Belongs to the ABC transporter superfamily
A4U70_RS08540	COG4608	Belongs to the ABC transporter superfamily
A4U70_RS08550	COG0826	peptidase U32
A4U70_RS08555	COG0745	RESPONSE REGULATOR receiver
A4U70_RS08560	COG2205	protein histidine kinase activity
A4U70_RS08585	COG1301	dicarboxylic acid transport
A4U70_RS08600	COG5002	protein histidine kinase activity
A4U70_RS08605	COG0443	Heat shock 70 kDa protein
A4U70_RS08610	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A4U70_RS08625	COG2982	Protein involved in outer membrane biogenesis
A4U70_RS08630	COG1253	flavin adenine dinucleotide binding
A4U70_RS08760	COG0438	transferase activity, transferring glycosyl groups
A4U70_RS08765	COG1215	transferase activity, transferring glycosyl groups
A4U70_RS08785	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A4U70_RS08810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4U70_RS08815	COG0583	DNA-binding transcription factor activity
A4U70_RS08820	COG0531	amino acid
A4U70_RS08825	COG0640	Transcriptional regulator
A4U70_RS08830	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A4U70_RS08840	COG2925	Exonuclease
A4U70_RS08855	COG1289	transmembrane transporter activity
A4U70_RS08875	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A4U70_RS08885	COG1942	4-Oxalocrotonate Tautomerase
A4U70_RS08890	COG0583	DNA-binding transcription factor activity
A4U70_RS08895	COG0095	Lipoate-protein ligase
A4U70_RS08900	COG0477	Major facilitator Superfamily
A4U70_RS08915	COG3300	MHYT domain
A4U70_RS08915	COG5001	Diguanylate cyclase
A4U70_RS08925	COG3615	Tellurite resistance protein tehB
A4U70_RS08950	COG3706	GGDEF domain
A4U70_RS08980	COG3423	Transcriptional regulator
A4U70_RS09005	COG0534	Mate efflux family protein
A4U70_RS09015	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A4U70_RS09035	COG0604	alcohol dehydrogenase
A4U70_RS09040	COG1309	transcriptional regulator
A4U70_RS09045	COG0025	NhaP-type Na H and K H
A4U70_RS09090	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A4U70_RS09100	COG1418	mRNA catabolic process
A4U70_RS09105	COG0270	DNA (cytosine-5-)-methyltransferase activity
A4U70_RS09110	COG3727	T/G mismatch-specific endonuclease activity
A4U70_RS09115	COG0697	spore germination
A4U70_RS09120	COG2354	Protein conserved in bacteria
A4U70_RS09150	COG0366	Alpha amylase catalytic
A4U70_RS09155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4U70_RS09165	COG0765	amino acid transport
A4U70_RS09170	COG1126	abc transporter atp-binding protein
A4U70_RS09175	COG2197	response regulator
A4U70_RS09185	COG2197	response regulator
A4U70_RS09220	COG3318	Belongs to the UPF0149 family
A4U70_RS09220	COG3012	SEC-C Motif Domain Protein
A4U70_RS09225	COG0814	amino acid
A4U70_RS09235	COG1528	Iron-storage protein
A4U70_RS09250	COG0477	Major facilitator Superfamily
A4U70_RS09260	COG2211	Major facilitator Superfamily
A4U70_RS09270	COG1528	Iron-storage protein
A4U70_RS09280	COG1879	ABC-type sugar transport system periplasmic component
A4U70_RS09290	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4U70_RS09315	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A4U70_RS09325	COG3102	Protein conserved in bacteria
A4U70_RS09345	COG3788	relative of glutathione S-transferase, MAPEG superfamily
A4U70_RS09350	COG1801	Protein of unknown function DUF72
A4U70_RS09355	COG1335	isochorismatase
A4U70_RS09365	COG0494	nUDIX hydrolase
A4U70_RS09390	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A4U70_RS09400	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
A4U70_RS09405	COG0739	heme binding
A4U70_RS09410	COG1560	Kdo2-lipid A biosynthetic process
A4U70_RS09420	COG1737	Transcriptional regulator
A4U70_RS09435	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A4U70_RS09440	COG0129	dihydroxy-acid dehydratase activity
A4U70_RS09445	COG0800	Aldolase
A4U70_RS09455	COG3141	response to X-ray
A4U70_RS09460	COG2979	Protein of unknown function (DUF533)
A4U70_RS09465	COG1770	oligopeptidase
A4U70_RS09470	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A4U70_RS09480	COG2372	response to copper ion
A4U70_RS09485	COG1276	copper resistance
A4U70_RS09500	COG2990	Protein conserved in bacteria
A4U70_RS09525	COG3008	intermembrane lipid transfer
A4U70_RS09530	COG2995	paraquat-inducible protein a
A4U70_RS09535	COG1956	GAF domain-containing protein
A4U70_RS09555	COG2814	Major facilitator Superfamily
A4U70_RS09560	COG1414	Transcriptional regulator
A4U70_RS09600	COG0768	penicillin binding
A4U70_RS09605	COG2226	methyltransferase
A4U70_RS09625	COG3716	PTS system mannose fructose sorbose family IID component
A4U70_RS09630	COG3715	PTS system
A4U70_RS09635	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4U70_RS09635	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4U70_RS09640	COG1253	flavin adenine dinucleotide binding
A4U70_RS09645	COG2200	EAL domain
A4U70_RS09650	COG1760	l-serine dehydratase
A4U70_RS09670	COG0251	oxidation-reduction process
A4U70_RS09675	COG1199	ATP-dependent helicase activity
A4U70_RS09685	COG3065	identical protein binding
A4U70_RS09695	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A4U70_RS09705	COG2894	cell division
A4U70_RS09720	COG0179	Fumarylacetoacetate (FAA) hydrolase
A4U70_RS09750	COG2719	SpoVR family
A4U70_RS09770	COG1619	proteins homologs of microcin C7 resistance protein MccF
A4U70_RS09780	COG4774	siderophore transport
A4U70_RS09795	COG2308	Evidence 4 Homologs of previously reported genes of
A4U70_RS09835	COG0583	DNA-binding transcription factor activity
A4U70_RS09840	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A4U70_RS09855	COG1882	Formate acetyltransferase
A4U70_RS09885	COG0583	DNA-binding transcription factor activity
A4U70_RS09915	COG0583	DNA-binding transcription factor activity
A4U70_RS09930	COG3122	Protein conserved in bacteria
A4U70_RS09960	COG2885	chlorophyll binding
A4U70_RS09980	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A4U70_RS09985	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A4U70_RS09990	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A4U70_RS10050	COG0012	GTP binding
A4U70_RS10070	COG0659	secondary active sulfate transmembrane transporter activity
A4U70_RS10105	COG2890	protein-(glutamine-N5) methyltransferase activity
A4U70_RS10125	COG0387	Pfam Sodium calcium exchanger
A4U70_RS10130	COG4572	Cation transport regulator
A4U70_RS10135	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
A4U70_RS10145	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
A4U70_RS10150	COG3707	response regulator
A4U70_RS10155	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A4U70_RS10165	COG1116	anion transmembrane transporter activity
A4U70_RS10170	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A4U70_RS10170	COG2146	nitrite reductase [NAD(P)H] activity
A4U70_RS10175	COG0243	molybdopterin cofactor binding
A4U70_RS10180	COG4932	domain protein
A4U70_RS10185	COG2197	response regulator
A4U70_RS10190	COG3850	Histidine kinase
A4U70_RS10195	COG2223	nitrite transmembrane transporter activity
A4U70_RS10200	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A4U70_RS10205	COG1140	nitrate reductase beta subunit
A4U70_RS10210	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
A4U70_RS10215	COG2181	nitrate reductase activity
A4U70_RS10225	COG1522	sequence-specific DNA binding
A4U70_RS10250	COG0788	formyltetrahydrofolate deformylase activity
A4U70_RS10260	COG0745	RESPONSE REGULATOR receiver
A4U70_RS10265	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A4U70_RS10270	COG2916	Histone family protein nucleoid-structuring protein H-NS
A4U70_RS10275	COG1435	thymidine kinase activity
A4U70_RS10280	COG1454	alcohol dehydrogenase
A4U70_RS10280	COG1012	belongs to the aldehyde dehydrogenase family
A4U70_RS10290	COG2095	MarC family integral membrane protein
A4U70_RS10295	COG4166	transmembrane transport
A4U70_RS10300	COG0601	transmembrane transport
A4U70_RS10305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4U70_RS10310	COG0444	Belongs to the ABC transporter superfamily
A4U70_RS10320	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4U70_RS10340	COG2353	YceI-like domain
A4U70_RS10345	COG2350	Protein conserved in bacteria
A4U70_RS10355	COG3001	Fructosamine kinase
A4U70_RS10365	COG1105	Belongs to the carbohydrate kinase PfkB family
A4U70_RS10370	COG3137	Salt-induced outer membrane protein
A4U70_RS10410	COG0072	phenylalanine-tRNA ligase activity
A4U70_RS10410	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4U70_RS10430	COG0583	DNA-binding transcription factor activity
A4U70_RS10450	COG0386	Belongs to the glutathione peroxidase family
A4U70_RS10460	COG0791	NLP P60 protein
A4U70_RS10470	COG4256	Hemin uptake protein
A4U70_RS10475	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A4U70_RS10490	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4U70_RS10490	COG0574	Belongs to the PEP-utilizing enzyme family
A4U70_RS10500	COG0628	permease
A4U70_RS10505	COG0247	lactate metabolic process
A4U70_RS10505	COG0277	FAD linked oxidase domain protein
A4U70_RS10510	COG2050	protein possibly involved in aromatic compounds catabolism
A4U70_RS10515	COG2261	transglycosylase associated protein
A4U70_RS10545	COG1120	ATPase activity
A4U70_RS10550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4U70_RS10560	COG0583	DNA-binding transcription factor activity
A4U70_RS10585	COG1304	FMN binding
A4U70_RS10595	COG0316	Belongs to the HesB IscA family
A4U70_RS10600	COG0719	Fe-S assembly protein
A4U70_RS10605	COG0396	ATPase activity
A4U70_RS10610	COG0719	Fe-S assembly protein
A4U70_RS10625	COG1376	ErfK ybiS ycfS ynhG family protein
A4U70_RS10650	COG1309	transcriptional regulator
A4U70_RS10660	COG2271	Major facilitator Superfamily
A4U70_RS10665	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A4U70_RS10675	COG1120	ATPase activity
A4U70_RS10680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4U70_RS10685	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A4U70_RS10690	COG1414	Transcriptional regulator
A4U70_RS10725	COG2814	Major facilitator Superfamily
A4U70_RS10745	COG0583	DNA-binding transcription factor activity
A4U70_RS10750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4U70_RS10770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4U70_RS10775	COG1116	anion transmembrane transporter activity
A4U70_RS10780	COG4774	siderophore transport
A4U70_RS10785	COG1120	ATPase activity
A4U70_RS10790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4U70_RS10795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4U70_RS10815	COG0765	amino acid transport
A4U70_RS10820	COG1126	abc transporter atp-binding protein
A4U70_RS10855	COG1473	amidohydrolase
A4U70_RS10860	COG3383	formate dehydrogenase (NAD+) activity
A4U70_RS10865	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A4U70_RS10880	COG1175	transmembrane transport
A4U70_RS10910	COG4133	protoheme IX ABC transporter activity
A4U70_RS10915	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A4U70_RS10920	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A4U70_RS10935	COG1138	Cytochrome C-type biogenesis protein
A4U70_RS10940	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4U70_RS10945	COG4235	cytochrome complex assembly
A4U70_RS10945	COG3088	subunit of a heme lyase
A4U70_RS10970	COG5002	protein histidine kinase activity
A4U70_RS10970	COG3850	Histidine kinase
A4U70_RS10975	COG0745	RESPONSE REGULATOR receiver
A4U70_RS10995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4U70_RS11025	COG1028	Short-chain dehydrogenase reductase Sdr
A4U70_RS11030	COG2610	gluconate transmembrane transporter activity
A4U70_RS11035	COG1250	3-hydroxyacyl-CoA dehydrogenase
A4U70_RS11045	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A4U70_RS11055	COG0583	DNA-binding transcription factor activity
A4U70_RS11075	COG0277	FAD linked oxidase domain protein
A4U70_RS11080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4U70_RS11105	COG0402	S-adenosylhomocysteine deaminase activity
A4U70_RS11150	COG3321	synthase
A4U70_RS11150	COG0604	alcohol dehydrogenase
A4U70_RS11150	COG1028	Short-chain dehydrogenase reductase Sdr
A4U70_RS11180	COG4608	Belongs to the ABC transporter superfamily
A4U70_RS11185	COG0444	Belongs to the ABC transporter superfamily
A4U70_RS11210	COG0346	lactoylglutathione lyase activity
A4U70_RS11215	COG1349	DNA-binding transcription factor activity
A4U70_RS11245	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A4U70_RS11265	COG0300	oxidoreductase activity
A4U70_RS11310	COG0307	riboflavin synthase, alpha
A4U70_RS11315	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A4U70_RS11320	COG2814	Major facilitator Superfamily
A4U70_RS11325	COG0583	DNA-binding transcription factor activity
A4U70_RS11335	COG2814	Major facilitator Superfamily
A4U70_RS11350	COG0791	NLP P60 protein
A4U70_RS11355	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A4U70_RS11365	COG0346	lactoylglutathione lyase activity
A4U70_RS11370	COG1902	pentaerythritol trinitrate reductase activity
A4U70_RS11375	COG1309	transcriptional regulator
A4U70_RS11380	COG3313	Fe-S protein
A4U70_RS11385	COG4989	oxidoreductase activity
A4U70_RS11390	COG2032	superoxide dismutase activity
A4U70_RS11395	COG1289	transmembrane transporter activity
A4U70_RS11400	COG1566	PFAM secretion protein HlyD family protein
A4U70_RS11415	COG3706	GGDEF domain
A4U70_RS11430	COG3895	Periplasmic Protein
A4U70_RS11445	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
A4U70_RS11450	COG0625	glutathione transferase activity
A4U70_RS11465	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A4U70_RS11475	COG4659	FMN binding
A4U70_RS11510	COG2723	6-phospho-beta-galactosidase activity
A4U70_RS11520	COG0673	inositol 2-dehydrogenase activity
A4U70_RS11530	COG2814	Major facilitator Superfamily
A4U70_RS11550	COG3038	cytochrome b561
A4U70_RS11570	COG0583	DNA-binding transcription factor activity
A4U70_RS11575	COG3485	protocatechuate 3,4-dioxygenase
A4U70_RS11580	COG3485	protocatechuate 3,4-dioxygenase
A4U70_RS11585	COG5383	Protein conserved in bacteria
A4U70_RS11590	COG2272	Belongs to the type-B carboxylesterase lipase family
A4U70_RS11605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4U70_RS11610	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A4U70_RS11615	COG1275	C4-dicarboxylate transporter malic acid transport protein
A4U70_RS11620	COG0500	methyltransferase
A4U70_RS11635	COG3708	Transcriptional regulator
A4U70_RS11635	COG2207	Transcriptional regulator
A4U70_RS11640	COG3135	benzoate transporter
A4U70_RS11645	COG1396	sequence-specific DNA binding
A4U70_RS11655	COG0826	peptidase U32
A4U70_RS11670	COG1294	oxidase, subunit
A4U70_RS11675	COG1271	oxidase subunit
A4U70_RS11680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4U70_RS11685	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A4U70_RS11690	COG3842	ATPase activity
A4U70_RS11695	COG1176	ABC-type spermidine putrescine transport system, permease component I
A4U70_RS11700	COG1177	transmembrane transport
A4U70_RS11705	COG1012	belongs to the aldehyde dehydrogenase family
A4U70_RS11740	COG1012	belongs to the aldehyde dehydrogenase family
A4U70_RS11745	COG0747	negative chemotaxis
A4U70_RS11755	COG3238	Protein conserved in bacteria
A4U70_RS11760	COG1247	-acetyltransferase
A4U70_RS11770	COG2130	NADP-dependent
A4U70_RS11785	COG3691	Protein conserved in bacteria
A4U70_RS11790	COG1228	amidohydrolase
A4U70_RS11795	COG4772	TonB-dependent receptor
A4U70_RS11820	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A4U70_RS11825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4U70_RS11830	COG1473	amidohydrolase
A4U70_RS11835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4U70_RS11840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4U70_RS11850	COG0765	amino acid transport
A4U70_RS11855	COG1126	abc transporter atp-binding protein
A4U70_RS11865	COG0625	glutathione transferase activity
A4U70_RS11890	COG2211	Major facilitator Superfamily
A4U70_RS11905	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A4U70_RS11910	COG3842	ATPase activity
A4U70_RS11915	COG1840	ABC-type Fe3 transport system, periplasmic component
A4U70_RS11920	COG1178	ABC-type Fe3 transport system permease component
A4U70_RS11925	COG2162	N-hydroxyarylamine O-acetyltransferase activity
A4U70_RS11935	COG2181	nitrate reductase activity
A4U70_RS11940	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
A4U70_RS11945	COG1140	nitrate reductase beta subunit
A4U70_RS11950	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A4U70_RS11955	COG2223	nitrite transmembrane transporter activity
A4U70_RS11970	COG1414	Transcriptional regulator
A4U70_RS11975	COG4948	Mandelate Racemase Muconate Lactonizing
A4U70_RS11980	COG4829	muconolactone delta-isomerase
A4U70_RS11985	COG3485	protocatechuate 3,4-dioxygenase
A4U70_RS11995	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
A4U70_RS12015	COG3383	formate dehydrogenase (NAD+) activity
A4U70_RS12015	COG0243	molybdopterin cofactor binding
A4U70_RS12020	COG3383	formate dehydrogenase (NAD+) activity
A4U70_RS12020	COG0243	molybdopterin cofactor binding
A4U70_RS12025	COG0437	4 iron, 4 sulfur cluster binding
A4U70_RS12030	COG2864	formate dehydrogenase
A4U70_RS12045	COG2326	polyphosphate kinase activity
A4U70_RS12055	COG2814	Major facilitator Superfamily
A4U70_RS12065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4U70_RS12075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4U70_RS12085	COG0747	negative chemotaxis
A4U70_RS12090	COG1064	alcohol dehydrogenase
A4U70_RS12105	COG0488	(ABC) transporter
A4U70_RS12140	COG1028	Short-chain dehydrogenase reductase Sdr
A4U70_RS12145	COG3729	General stress protein
A4U70_RS12165	COG3685	Protein conserved in bacteria
A4U70_RS12175	COG0366	Alpha amylase catalytic
A4U70_RS12185	COG2323	membrane
A4U70_RS12195	COG3111	PFAM Bacterial OB fold (BOF) protein
A4U70_RS12205	COG1764	response to oxidative stress
A4U70_RS12230	COG3781	membrane
A4U70_RS12235	COG0243	molybdopterin cofactor binding
A4U70_RS12240	COG0583	DNA-binding transcription factor activity
A4U70_RS12245	COG2814	Major facilitator Superfamily
A4U70_RS12255	COG1285	pathogenesis
A4U70_RS12260	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A4U70_RS12270	COG0583	DNA-binding transcription factor activity
A4U70_RS12290	COG0519	Catalyzes the synthesis of GMP from XMP
A4U70_RS12290	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A4U70_RS12330	COG0596	Alpha beta hydrolase
A4U70_RS12340	COG2205	protein histidine kinase activity
A4U70_RS12355	COG0076	glutamate decarboxylase activity
A4U70_RS12360	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A4U70_RS12365	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A4U70_RS12370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4U70_RS12375	COG1116	anion transmembrane transporter activity
A4U70_RS12380	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A4U70_RS12395	COG0673	inositol 2-dehydrogenase activity
A4U70_RS12410	COG3706	GGDEF domain
A4U70_RS12415	COG0402	S-adenosylhomocysteine deaminase activity
A4U70_RS12420	COG1953	Uracil, thiamine, allantoin
A4U70_RS12455	COG0406	alpha-ribazole phosphatase activity
A4U70_RS12465	COG1335	isochorismatase
A4U70_RS12480	COG2207	Transcriptional regulator
A4U70_RS12500	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A4U70_RS12565	COG0765	amino acid transport
A4U70_RS12575	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A4U70_RS12585	COG2070	2-Nitropropane dioxygenase
A4U70_RS12590	COG0583	DNA-binding transcription factor activity
A4U70_RS12600	COG1902	pentaerythritol trinitrate reductase activity
A4U70_RS12610	COG0477	Major facilitator Superfamily
A4U70_RS12635	COG2223	nitrite transmembrane transporter activity
A4U70_RS12645	COG1609	Transcriptional regulator
A4U70_RS12650	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4U70_RS12660	COG3037	sugar-specific permease SgaT UlaA
A4U70_RS12665	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A4U70_RS12675	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4U70_RS12680	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4U70_RS12680	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4U70_RS12680	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
A4U70_RS12695	COG0583	DNA-binding transcription factor activity
A4U70_RS12700	COG0583	DNA-binding transcription factor activity
A4U70_RS12705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4U70_RS12715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4U70_RS12730	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4U70_RS12740	COG1609	Transcriptional regulator
A4U70_RS12770	COG1652	LysM domain
A4U70_RS12800	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A4U70_RS12800	COG0456	acetyltransferase
A4U70_RS12810	COG0667	Aldo Keto reductase
A4U70_RS12815	COG0667	Aldo Keto reductase
A4U70_RS12820	COG3386	PFAM SMP-30 Gluconolaconase
A4U70_RS12825	COG0667	Aldo Keto reductase
A4U70_RS12860	COG4977	sequence-specific DNA binding
A4U70_RS12880	COG4977	sequence-specific DNA binding
A4U70_RS12885	COG1349	DNA-binding transcription factor activity
A4U70_RS12905	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A4U70_RS12910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4U70_RS12915	COG0738	Major facilitator superfamily
A4U70_RS12960	COG1929	Belongs to the glycerate kinase type-1 family
A4U70_RS12965	COG3835	regulator
A4U70_RS12975	COG0583	DNA-binding transcription factor activity
A4U70_RS12985	COG2186	Transcriptional regulator
A4U70_RS12990	COG1263	PTS System
A4U70_RS12990	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4U70_RS13000	COG2814	Major facilitator Superfamily
A4U70_RS13005	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4U70_RS13005	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4U70_RS13015	COG2819	hydrolase of the alpha beta superfamily
A4U70_RS13020	COG5001	Diguanylate cyclase
A4U70_RS13020	COG3300	MHYT domain
A4U70_RS13055	COG3188	usher protein
A4U70_RS13070	COG1649	PFAM Uncharacterised BCR, COG1649
A4U70_RS13075	COG3550	peptidyl-serine autophosphorylation
A4U70_RS13080	COG1396	sequence-specific DNA binding
A4U70_RS13085	COG2351	hydroxyisourate hydrolase activity
A4U70_RS13090	COG3648	Uricase
A4U70_RS13090	COG3195	allantoin biosynthetic process
A4U70_RS13095	COG2233	PERMEase
A4U70_RS13125	COG2207	Transcriptional regulator
A4U70_RS13140	COG4628	conserved protein (DUF2132)
A4U70_RS13160	COG2011	ABC-type metal ion transport system permease component
A4U70_RS13165	COG2070	2-Nitropropane dioxygenase
A4U70_RS13175	COG0477	Major facilitator Superfamily
A4U70_RS13260	COG1012	belongs to the aldehyde dehydrogenase family
A4U70_RS13265	COG0583	DNA-binding transcription factor activity
A4U70_RS13275	COG0039	L-malate dehydrogenase activity
A4U70_RS13280	COG1349	DNA-binding transcription factor activity
A4U70_RS13285	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A4U70_RS13290	COG3395	kinase activity
A4U70_RS13300	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4U70_RS13305	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4U70_RS13310	COG2271	Major facilitator Superfamily
A4U70_RS13335	COG4977	sequence-specific DNA binding
A4U70_RS13345	COG0697	spore germination
A4U70_RS13350	COG2814	Major facilitator Superfamily
A4U70_RS13380	COG0683	leucine binding
A4U70_RS13385	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A4U70_RS13420	COG2223	nitrite transmembrane transporter activity
A4U70_RS13425	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A4U70_RS13440	COG1349	DNA-binding transcription factor activity
A4U70_RS13445	COG2084	Dehydrogenase
A4U70_RS13450	COG3395	kinase activity
A4U70_RS13455	COG0235	Class ii aldolase
A4U70_RS13460	COG3622	Belongs to the hyi family
A4U70_RS13465	COG2610	gluconate transmembrane transporter activity
A4U70_RS13470	COG3708	Transcriptional regulator
A4U70_RS13470	COG2207	Transcriptional regulator
A4U70_RS13485	COG2200	EAL domain
A4U70_RS13490	COG1546	Belongs to the CinA family
A4U70_RS13495	COG0071	Belongs to the small heat shock protein (HSP20) family
A4U70_RS13505	COG2197	response regulator
A4U70_RS13510	COG2135	peptidase activity
A4U70_RS13515	COG2207	Transcriptional regulator
A4U70_RS13530	COG4221	oxidoreductase activity
A4U70_RS13535	COG1802	Transcriptional regulator
A4U70_RS13540	COG0589	response to stress
A4U70_RS13545	COG0246	Mannitol dehydrogenase
A4U70_RS13550	COG2271	Major facilitator Superfamily
A4U70_RS13565	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4U70_RS13580	COG0243	molybdopterin cofactor binding
A4U70_RS13585	COG0437	4 iron, 4 sulfur cluster binding
A4U70_RS13590	COG3302	dmso reductase anchor subunit
A4U70_RS13605	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A4U70_RS13610	COG1940	carbohydrate kinase activity
A4U70_RS13615	COG0583	DNA-binding transcription factor activity
A4U70_RS13620	COG2814	Major facilitator Superfamily
A4U70_RS13625	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A4U70_RS13635	COG3591	Belongs to the peptidase S1B family
A4U70_RS13660	COG0628	permease
A4U70_RS13690	COG0679	Auxin Efflux Carrier
A4U70_RS13700	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A4U70_RS13725	COG3290	protein histidine kinase activity
A4U70_RS13730	COG4565	transcriptional regulatory protein
A4U70_RS13755	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A4U70_RS13755	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A4U70_RS13775	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A4U70_RS13780	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A4U70_RS13790	COG0183	Belongs to the thiolase family
A4U70_RS13795	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A4U70_RS13805	COG1414	Transcriptional regulator
A4U70_RS13810	COG2840	Smr protein MutS2
A4U70_RS13815	COG0583	DNA-binding transcription factor activity
A4U70_RS13825	COG1473	amidohydrolase
A4U70_RS13830	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A4U70_RS13950	COG4626	Terminase
A4U70_RS13950	COG1802	Transcriptional regulator
A4U70_RS13990	COG3179	chitinase
A4U70_RS14010	COG1403	HNH endonuclease
A4U70_RS14015	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
A4U70_RS14025	COG1846	Transcriptional regulator
A4U70_RS14125	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A4U70_RS14140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4U70_RS14155	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A4U70_RS14160	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A4U70_RS14180	COG0531	amino acid
A4U70_RS14190	COG3136	membrane protein required for alginate biosynthesis
A4U70_RS14195	COG0745	RESPONSE REGULATOR receiver
A4U70_RS14205	COG2205	protein histidine kinase activity
A4U70_RS14215	COG0114	fumarate hydratase activity
A4U70_RS14220	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A4U70_RS14220	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A4U70_RS14225	COG1482	cell wall glycoprotein biosynthetic process
A4U70_RS14230	COG5339	Protein conserved in bacteria
A4U70_RS14235	COG1609	Transcriptional regulator
A4U70_RS14240	COG1263	PTS System
A4U70_RS14240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4U70_RS14245	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A4U70_RS14270	COG2391	methyltransferase activity
A4U70_RS14275	COG0425	Belongs to the sulfur carrier protein TusA family
A4U70_RS14280	COG5562	phage envelope protein
A4U70_RS14285	COG0401	homolog of Blt101
A4U70_RS14290	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A4U70_RS14295	COG1012	belongs to the aldehyde dehydrogenase family
A4U70_RS14300	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A4U70_RS14310	COG1113	amino acid transport
A4U70_RS14315	COG2988	succinylglutamate desuccinylase activity
A4U70_RS14320	COG3724	N-succinylarginine dihydrolase activity
A4U70_RS14325	COG1012	belongs to the aldehyde dehydrogenase family
A4U70_RS14330	COG3138	arginine N-succinyltransferase
A4U70_RS14335	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A4U70_RS14340	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A4U70_RS14345	COG0667	Aldo Keto reductase
A4U70_RS14350	COG0583	DNA-binding transcription factor activity
A4U70_RS14375	COG4122	O-methyltransferase activity
A4U70_RS14380	COG1643	Atp-dependent helicase
A4U70_RS14395	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A4U70_RS14400	COG3327	negative regulation of DNA-templated transcription, initiation
A4U70_RS14405	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
A4U70_RS14410	COG0183	Belongs to the thiolase family
A4U70_RS14415	COG2050	protein possibly involved in aromatic compounds catabolism
A4U70_RS14420	COG1250	3-hydroxyacyl-CoA dehydrogenase
A4U70_RS14425	COG1024	Enoyl-CoA hydratase
A4U70_RS14430	COG1024	Enoyl-CoA hydratase
A4U70_RS14435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A4U70_RS14440	COG2151	metal-sulfur cluster biosynthetic enzyme
A4U70_RS14445	COG3396	Phenylacetate-CoA oxygenase
A4U70_RS14450	COG3460	Phenylacetate-CoA oxygenase
A4U70_RS14455	COG3396	Phenylacetate-CoA oxygenase
A4U70_RS14460	COG1012	belongs to the aldehyde dehydrogenase family
A4U70_RS14460	COG2030	dehydratase
A4U70_RS14485	COG1012	belongs to the aldehyde dehydrogenase family
A4U70_RS14490	COG2207	Transcriptional regulator
A4U70_RS14495	COG3784	Protein of unknown function (DUF1318)
A4U70_RS14505	COG2911	Protein conserved in bacteria
A4U70_RS14510	COG0586	Pfam SNARE associated Golgi protein
A4U70_RS14515	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4U70_RS14520	COG3187	Heat shock protein
A4U70_RS14525	COG3042	response to heat
A4U70_RS14535	COG0674	pyruvate-flavodoxin oxidoreductase activity
A4U70_RS14535	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A4U70_RS14535	COG1013	pyruvate-flavodoxin oxidoreductase activity
A4U70_RS14535	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4U70_RS14540	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A4U70_RS14550	COG0589	response to stress
A4U70_RS14560	COG0513	Belongs to the DEAD box helicase family
A4U70_RS14580	COG1349	DNA-binding transcription factor activity
A4U70_RS14585	COG0673	inositol 2-dehydrogenase activity
A4U70_RS14600	COG1113	amino acid transport
A4U70_RS14605	COG1522	sequence-specific DNA binding
A4U70_RS14615	COG1448	Aminotransferase
A4U70_RS14620	COG2011	ABC-type metal ion transport system permease component
A4U70_RS14635	COG0436	Aminotransferase
A4U70_RS14640	COG0604	alcohol dehydrogenase
A4U70_RS14665	COG0583	DNA-binding transcription factor activity
A4U70_RS14685	COG1028	Short-chain dehydrogenase reductase Sdr
A4U70_RS14690	COG1309	transcriptional regulator
A4U70_RS14695	COG1028	Short-chain dehydrogenase reductase Sdr
A4U70_RS14780	COG2885	chlorophyll binding
A4U70_RS14805	COG0693	protein deglycase activity
A4U70_RS14810	COG1078	dGTPase activity
A4U70_RS14815	COG1028	Short-chain dehydrogenase reductase Sdr
A4U70_RS14820	COG0583	DNA-binding transcription factor activity
A4U70_RS14840	COG0656	L-ascorbic acid biosynthetic process
A4U70_RS14870	COG4166	transmembrane transport
A4U70_RS14875	COG2866	Carboxypeptidase
A4U70_RS14880	COG4948	Mandelate Racemase Muconate Lactonizing
A4U70_RS14885	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A4U70_RS14890	COG3180	Ammonia monooxygenase
A4U70_RS14900	COG1486	melibiose metabolic process
A4U70_RS14905	COG0583	DNA-binding transcription factor activity
A4U70_RS14915	COG3106	COG3106 Predicted ATPase
A4U70_RS14925	COG1983	PspC domain protein
A4U70_RS14935	COG1842	Phage shock protein A
A4U70_RS14940	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A4U70_RS14950	COG1473	amidohydrolase
A4U70_RS14965	COG0702	epimerase
A4U70_RS14980	COG4171	peptide transport system, permease
A4U70_RS14995	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A4U70_RS15005	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A4U70_RS15010	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A4U70_RS15010	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A4U70_RS15025	COG1349	DNA-binding transcription factor activity
A4U70_RS15035	COG0023	Translation Initiation Factor
A4U70_RS15045	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
A4U70_RS15050	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
A4U70_RS15055	COG0671	phosphoesterase, PA-phosphatase related
A4U70_RS15065	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A4U70_RS15100	COG0616	signal peptide processing
A4U70_RS15110	COG1028	Short-chain dehydrogenase reductase Sdr
A4U70_RS15115	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
A4U70_RS15125	COG0583	DNA-binding transcription factor activity
A4U70_RS15135	COG0009	L-threonylcarbamoyladenylate synthase
A4U70_RS15145	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A4U70_RS15150	COG0512	Glutamine amidotransferase of anthranilate synthase
A4U70_RS15150	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A4U70_RS15155	COG0135	phosphoribosylanthranilate isomerase activity
A4U70_RS15155	COG0134	indole-3-glycerol-phosphate synthase activity
A4U70_RS15210	COG4774	siderophore transport
A4U70_RS15220	COG3047	cAMP biosynthetic process
A4U70_RS15225	COG0727	PFAM Uncharacterised protein family (UPF0153)
A4U70_RS15255	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4U70_RS15260	COG1028	Short-chain dehydrogenase reductase Sdr
A4U70_RS15265	COG1988	membrane-bound metal-dependent
A4U70_RS15270	COG1823	symporter activity
A4U70_RS15280	COG0753	catalase activity
A4U70_RS15290	COG1486	melibiose metabolic process
A4U70_RS15295	COG2169	Transcriptional regulator
A4U70_RS15295	COG1917	Cupin 2, conserved barrel domain protein
A4U70_RS15300	COG1447	Phosphotransferase system cellobiose-specific component IIA
A4U70_RS15305	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A4U70_RS15310	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A4U70_RS15315	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A4U70_RS15325	COG0322	excinuclease ABC activity
A4U70_RS15330	COG3678	ATP-independent chaperone mediated protein folding
A4U70_RS15340	COG3724	N-succinylarginine dihydrolase activity
A4U70_RS15350	COG3138	arginine N-succinyltransferase
A4U70_RS15360	COG0708	Exodeoxyribonuclease III
A4U70_RS15365	COG0398	Pfam SNARE associated Golgi protein
A4U70_RS15370	COG0398	Pfam SNARE associated Golgi protein
A4U70_RS15375	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A4U70_RS15380	COG4134	Bacterial extracellular solute-binding protein
A4U70_RS15385	COG4135	transport system, permease component
A4U70_RS15390	COG4136	ATPase activity
A4U70_RS15395	COG2897	thiosulfate sulfurtransferase activity
A4U70_RS15400	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A4U70_RS15405	COG0494	nUDIX hydrolase
A4U70_RS15410	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A4U70_RS15415	COG0604	alcohol dehydrogenase
A4U70_RS15415	COG1028	Short-chain dehydrogenase reductase Sdr
A4U70_RS15415	COG3321	synthase
A4U70_RS15420	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A4U70_RS15425	COG0709	Synthesizes selenophosphate from selenide and ATP
A4U70_RS15440	COG0778	Nitroreductase
A4U70_RS15445	COG0616	signal peptide processing
A4U70_RS15450	COG0252	asparaginase activity
A4U70_RS15455	COG1335	isochorismatase
A4U70_RS15470	COG3139	Protein of unknown function (DUF1315)
A4U70_RS15490	COG0656	L-ascorbic acid biosynthetic process
A4U70_RS15495	COG3713	MltA-interacting MipA family protein
A4U70_RS15500	COG2766	serine protein kinase
A4U70_RS15515	COG0386	Belongs to the glutathione peroxidase family
A4U70_RS15535	COG1028	Short-chain dehydrogenase reductase Sdr
A4U70_RS15540	COG0583	DNA-binding transcription factor activity
A4U70_RS15545	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A4U70_RS15550	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A4U70_RS15560	COG0859	PFAM glycosyl transferase family 9
A4U70_RS15565	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A4U70_RS15575	COG2207	Transcriptional regulator
A4U70_RS15580	COG2807	transmembrane transport
A4U70_RS15585	COG0504	CTP synthase activity
A4U70_RS15590	COG1683	Conserved Protein
A4U70_RS15595	COG3189	MarR family transcriptional regulator
A4U70_RS15600	COG3042	response to heat
A4U70_RS15605	COG2199	diguanylate cyclase activity
A4U70_RS15605	COG2203	Gaf domain
A4U70_RS15625	COG3182	Iron-regulated membrane protein
A4U70_RS15635	COG1560	Kdo2-lipid A biosynthetic process
A4U70_RS15650	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A4U70_RS15655	COG3706	GGDEF domain
A4U70_RS15660	COG0583	DNA-binding transcription factor activity
A4U70_RS15665	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A4U70_RS15690	COG1294	oxidase, subunit
A4U70_RS15695	COG1271	oxidase subunit
A4U70_RS15700	COG3546	catalase activity
A4U70_RS15705	COG3685	Protein conserved in bacteria
A4U70_RS15710	COG3685	Protein conserved in bacteria
A4U70_RS15715	COG3729	General stress protein
A4U70_RS15720	COG1063	alcohol dehydrogenase
A4U70_RS15725	COG3813	Protein conserved in bacteria
A4U70_RS15750	COG0640	Transcriptional regulator
A4U70_RS15755	COG0538	isocitrate dehydrogenase activity
A4U70_RS15760	COG1187	pseudouridine synthase activity
A4U70_RS15780	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A4U70_RS15800	COG2205	protein histidine kinase activity
A4U70_RS15805	COG2850	peptidyl-arginine hydroxylation
A4U70_RS15825	COG1177	transmembrane transport
A4U70_RS15840	COG0318	PFAM AMP-dependent synthetase and ligase
A4U70_RS15845	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A4U70_RS15850	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A4U70_RS15855	COG0698	ribose 5-phosphate isomerase
A4U70_RS15870	COG3395	kinase activity
A4U70_RS15885	COG2390	Transcriptional regulator
A4U70_RS15895	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A4U70_RS15905	COG4591	ABC-type transport system involved in lipoprotein release permease component
A4U70_RS15915	COG4591	ABC-type transport system involved in lipoprotein release permease component
A4U70_RS15920	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A4U70_RS15925	COG1388	LysM domain
A4U70_RS15925	COG1376	ErfK ybiS ycfS ynhG family protein
A4U70_RS15935	COG1309	transcriptional regulator
A4U70_RS15945	COG3134	Outer membrane lipoprotein
A4U70_RS15950	COG1252	NADH dehydrogenase
A4U70_RS15980	COG5633	Lipoprotein
A4U70_RS15985	COG0537	adenosine 5'-monophosphoramidase activity
A4U70_RS15995	COG0084	hydrolase, TatD family'
A4U70_RS16000	COG0470	DNA polymerase III
A4U70_RS16010	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A4U70_RS16015	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4U70_RS16020	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A4U70_RS16035	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A4U70_RS16055	COG1399	metal-binding, possibly nucleic acid-binding protein
A4U70_RS16070	COG1530	ribonuclease E activity
A4U70_RS16075	COG0583	DNA-binding transcription factor activity
A4U70_RS16080	COG2814	Major facilitator Superfamily
A4U70_RS16100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4U70_RS16150	COG1560	Kdo2-lipid A biosynthetic process
A4U70_RS16170	COG5645	(Lipo)protein
A4U70_RS16210	COG3381	protein complex oligomerization
A4U70_RS16240	COG1309	transcriptional regulator
A4U70_RS16245	COG0583	DNA-binding transcription factor activity
A4U70_RS16255	COG1335	isochorismatase
A4U70_RS16265	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A4U70_RS16270	COG1702	phosphate starvation-inducible protein PhoH
A4U70_RS16290	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A4U70_RS16300	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4U70_RS16315	COG1309	transcriptional regulator
A4U70_RS16350	COG2233	PERMEase
A4U70_RS16365	COG3729	General stress protein
A4U70_RS16390	COG1028	Short-chain dehydrogenase reductase Sdr
A4U70_RS16405	COG0531	amino acid
A4U70_RS16415	COG0174	glutamine synthetase
A4U70_RS16420	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A4U70_RS16425	COG1396	sequence-specific DNA binding
A4U70_RS16425	COG1917	Cupin 2, conserved barrel domain protein
A4U70_RS16430	COG1012	belongs to the aldehyde dehydrogenase family
A4U70_RS16435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4U70_RS16440	COG0583	DNA-binding transcription factor activity
A4U70_RS16445	COG0473	3-isopropylmalate dehydrogenase activity
A4U70_RS16455	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A4U70_RS16460	COG4638	Rieske (2fe-2S)
A4U70_RS16465	COG1012	belongs to the aldehyde dehydrogenase family
A4U70_RS16470	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A4U70_RS16495	COG0670	Belongs to the BI1 family
A4U70_RS16510	COG2207	Transcriptional regulator
A4U70_RS16515	COG1881	PFAM PEBP family protein
A4U70_RS16540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4U70_RS16545	COG2274	protein secretion by the type I secretion system
A4U70_RS16565	COG1832	CoA-binding protein
A4U70_RS16575	COG0210	DNA helicase
A4U70_RS16580	COG3304	Inner membrane component domain
A4U70_RS16585	COG1289	transmembrane transporter activity
A4U70_RS16590	COG3070	regulator of competence-specific genes
A4U70_RS16615	COG1067	ATP-dependent peptidase activity
A4U70_RS16625	COG3130	regulation of translation
A4U70_RS16635	COG3009	Protein conserved in bacteria
A4U70_RS16640	COG3008	intermembrane lipid transfer
A4U70_RS16640	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A4U70_RS16645	COG2995	paraquat-inducible protein a
A4U70_RS16650	COG0488	(ABC) transporter
A4U70_RS16660	COG3217	Mosc domain protein beta barrel domain protein
A4U70_RS16660	COG0633	Ferredoxin
A4U70_RS16675	COG0431	NADPH-dependent FMN reductase
A4U70_RS16680	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A4U70_RS16685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4U70_RS16690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4U70_RS16700	COG0308	aminopeptidase N
A4U70_RS16710	COG1473	amidohydrolase
A4U70_RS16720	COG0814	amino acid
A4U70_RS16730	COG1522	sequence-specific DNA binding
A4U70_RS16740	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A4U70_RS16745	COG1448	Aminotransferase
A4U70_RS16750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4U70_RS16755	COG3108	Peptidase M15
A4U70_RS16765	COG2989	Protein conserved in bacteria
A4U70_RS16775	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
A4U70_RS16785	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A4U70_RS16790	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A4U70_RS16795	COG3173	Aminoglycoside phosphotransferase
A4U70_RS16810	COG3214	Protein conserved in bacteria
A4U70_RS16825	COG2333	competence protein COMEC
A4U70_RS16825	COG0658	competence protein
A4U70_RS16835	COG0539	negative regulation of cytoplasmic translation
A4U70_RS16855	COG2323	membrane
A4U70_RS16860	COG1944	ATP diphosphatase activity
A4U70_RS16865	COG2116	formate transmembrane transporter activity
A4U70_RS16870	COG1882	Formate acetyltransferase
A4U70_RS16875	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A4U70_RS16880	COG0477	Major facilitator Superfamily
A4U70_RS16890	COG3302	dmso reductase anchor subunit
A4U70_RS16895	COG0437	4 iron, 4 sulfur cluster binding
A4U70_RS16900	COG0243	molybdopterin cofactor binding
A4U70_RS16910	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A4U70_RS16920	COG1674	ftsk spoiiie
A4U70_RS16920	COG1178	ABC-type Fe3 transport system permease component
A4U70_RS16935	COG0492	ferredoxin-NADP+ reductase activity
A4U70_RS16940	COG4988	ABC transporter
A4U70_RS16945	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A4U70_RS16960	COG0542	response to heat
A4U70_RS16970	COG1278	Cold shock
A4U70_RS16985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4U70_RS16990	COG3593	DNA synthesis involved in DNA repair
A4U70_RS17000	COG2431	L-lysine efflux transmembrane transporter activity
A4U70_RS17010	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A4U70_RS17025	COG0028	Belongs to the TPP enzyme family
A4U70_RS17030	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
A4U70_RS17035	COG0702	epimerase
A4U70_RS17040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4U70_RS17045	COG3023	N-Acetylmuramoyl-L-alanine amidase
A4U70_RS17050	COG4251	negative regulation of phosphorylation
A4U70_RS17050	COG2203	Gaf domain
A4U70_RS17050	COG3706	GGDEF domain
A4U70_RS17050	COG5001	Diguanylate cyclase
A4U70_RS17065	COG1126	abc transporter atp-binding protein
A4U70_RS17070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4U70_RS17075	COG4215	(ABC) transporter
A4U70_RS17080	COG4160	amino acid transport
A4U70_RS17085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4U70_RS17090	COG5002	protein histidine kinase activity
A4U70_RS17095	COG0745	RESPONSE REGULATOR receiver
A4U70_RS17110	COG1177	transmembrane transport
A4U70_RS17115	COG1176	ABC-type spermidine putrescine transport system, permease component I
A4U70_RS17120	COG3842	ATPase activity
A4U70_RS17125	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A4U70_RS17140	COG0778	Nitroreductase
A4U70_RS17165	COG3226	Transcriptional regulator
A4U70_RS17170	COG0738	Major facilitator superfamily
A4U70_RS17175	COG0561	phosphatase activity
A4U70_RS17180	COG2814	Major facilitator Superfamily
A4U70_RS17190	COG0671	phosphoesterase, PA-phosphatase related
A4U70_RS17195	COG1349	DNA-binding transcription factor activity
A4U70_RS17200	COG1686	Belongs to the peptidase S11 family
A4U70_RS17205	COG0625	glutathione transferase activity
A4U70_RS17210	COG2133	pyrroloquinoline quinone binding
A4U70_RS17220	COG2223	nitrite transmembrane transporter activity
A4U70_RS17240	COG0747	negative chemotaxis
A4U70_RS17255	COG0303	'Molybdopterin
A4U70_RS17260	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A4U70_RS17265	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A4U70_RS17270	COG1882	Formate acetyltransferase
A4U70_RS17275	COG0561	phosphatase activity
A4U70_RS17285	COG1609	Transcriptional regulator
A4U70_RS17290	COG2271	Major facilitator Superfamily
A4U70_RS17300	COG0488	(ABC) transporter
A4U70_RS17305	COG2365	Tyrosine phosphatase family
A4U70_RS17310	COG1376	ErfK ybiS ycfS ynhG family protein
A4U70_RS17315	COG2188	Transcriptional regulator
A4U70_RS17320	COG2723	6-phospho-beta-galactosidase activity
A4U70_RS17325	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A4U70_RS17340	COG2194	sulfuric ester hydrolase activity
A4U70_RS17345	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A4U70_RS17360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4U70_RS17365	COG0765	amino acid transport
A4U70_RS17370	COG1126	abc transporter atp-binding protein
A4U70_RS17375	COG0668	transmembrane transport
A4U70_RS17385	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A4U70_RS17395	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A4U70_RS17405	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A4U70_RS17410	COG1199	ATP-dependent helicase activity
A4U70_RS17415	COG0513	Belongs to the DEAD box helicase family
A4U70_RS17420	COG3958	Transketolase
A4U70_RS17425	COG3959	Transketolase, thiamine diphosphate binding domain
A4U70_RS17430	COG1028	Short-chain dehydrogenase reductase Sdr
A4U70_RS17435	COG2271	Major facilitator Superfamily
A4U70_RS17440	COG0583	DNA-binding transcription factor activity
A4U70_RS17445	COG1309	transcriptional regulator
A4U70_RS17450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4U70_RS17455	COG1131	(ABC) transporter
A4U70_RS17460	COG0842	Transport permease protein
A4U70_RS17465	COG0842	Transport permease protein
A4U70_RS17475	COG3568	Endonuclease Exonuclease Phosphatase
A4U70_RS17480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A4U70_RS17485	COG0392	lysyltransferase activity
A4U70_RS17490	COG0670	Belongs to the BI1 family
A4U70_RS17495	COG0314	molybdopterin synthase activity
A4U70_RS17500	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A4U70_RS17510	COG0521	Mo-molybdopterin cofactor biosynthetic process
A4U70_RS17535	COG0745	RESPONSE REGULATOR receiver
A4U70_RS17540	COG0642	Histidine kinase
A4U70_RS17575	COG2226	methyltransferase
A4U70_RS17595	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A4U70_RS17600	COG1881	PFAM PEBP family protein
A4U70_RS17640	COG4677	pectinesterase activity
A4U70_RS17655	COG0589	response to stress
A4U70_RS17660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4U70_RS17690	COG0789	Transcriptional regulator
A4U70_RS17695	COG2200	EAL domain
A4U70_RS17720	COG0561	phosphatase activity
A4U70_RS17730	COG4149	molybdate abc transporter
A4U70_RS17735	COG0725	ABC transporter, periplasmic molybdate-binding protein
A4U70_RS17745	COG3585	molybdate ion transport
A4U70_RS17745	COG2005	Transcriptional regulator
A4U70_RS17750	COG1119	ATPase activity
A4U70_RS17760	COG1085	galactose-1-phosphate uridylyltransferase
A4U70_RS17770	COG2017	converts alpha-aldose to the beta-anomer
A4U70_RS17780	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A4U70_RS17795	COG3201	nicotinamide mononucleotide transporter
A4U70_RS17800	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A4U70_RS17840	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
A4U70_RS17845	COG2885	chlorophyll binding
A4U70_RS17855	COG3064	Membrane
A4U70_RS17860	COG0848	biopolymer transport protein
A4U70_RS17865	COG0811	peptide transport
A4U70_RS17870	COG0824	Thioesterase
A4U70_RS17875	COG3790	cyd operon protein YbgE
A4U70_RS17880	COG4890	Cyd operon protein YbgT
A4U70_RS17885	COG1294	oxidase, subunit
A4U70_RS17890	COG1271	oxidase subunit
A4U70_RS17900	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A4U70_RS17910	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4U70_RS17915	COG0567	Dehydrogenase, E1 component
A4U70_RS17920	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A4U70_RS17925	COG1053	succinate dehydrogenase
A4U70_RS17930	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A4U70_RS17935	COG2009	succinate dehydrogenase
A4U70_RS17975	COG1984	allophanate hydrolase subunit 2
A4U70_RS17980	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A4U70_RS17995	COG0415	Belongs to the DNA photolyase family
A4U70_RS18025	COG2205	protein histidine kinase activity
A4U70_RS18030	COG0745	RESPONSE REGULATOR receiver
A4U70_RS18040	COG0033	Phosphoglucomutase
A4U70_RS18045	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
A4U70_RS18050	COG0596	Alpha beta hydrolase
A4U70_RS18065	COG0735	belongs to the Fur family
A4U70_RS18110	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A4U70_RS18115	COG1940	carbohydrate kinase activity
A4U70_RS18115	COG1846	Transcriptional regulator
A4U70_RS18120	COG0647	UMP catabolic process
A4U70_RS18125	COG0367	asparagine synthase
A4U70_RS18170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4U70_RS18180	COG1702	phosphate starvation-inducible protein PhoH
A4U70_RS18205	COG0765	amino acid transport
A4U70_RS18210	COG0765	amino acid transport
A4U70_RS18215	COG1126	abc transporter atp-binding protein
A4U70_RS18230	COG2888	peptidyl-tyrosine sulfation
A4U70_RS18245	COG1466	dna polymerase III delta subunit
A4U70_RS18265	COG0799	negative regulation of ribosome biogenesis
A4U70_RS18275	COG0768	penicillin binding
A4U70_RS18280	COG0772	Belongs to the SEDS family
A4U70_RS18285	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A4U70_RS18290	COG1686	Belongs to the peptidase S11 family
A4U70_RS18305	COG0583	DNA-binding transcription factor activity
A4U70_RS18320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4U70_RS18340	COG3069	C4-dicarboxylate transmembrane transporter activity
A4U70_RS18345	COG3719	Belongs to the RNase T2 family
A4U70_RS18350	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A4U70_RS18370	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A4U70_RS18375	COG0583	DNA-binding transcription factor activity
A4U70_RS18380	COG3969	phosphoadenosine phosphosulfate
A4U70_RS18385	COG1475	DNA binding
A4U70_RS18390	COG0436	Aminotransferase
A4U70_RS18415	COG1129	ABC transporter
A4U70_RS18420	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4U70_RS18425	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4U70_RS18435	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4U70_RS18450	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A4U70_RS18460	COG0402	S-adenosylhomocysteine deaminase activity
A4U70_RS18470	COG0483	inositol monophosphate 1-phosphatase activity
A4U70_RS18475	COG2271	Major facilitator Superfamily
A4U70_RS18505	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4U70_RS18510	COG1129	ABC transporter
A4U70_RS18515	COG0371	Dehydrogenase
A4U70_RS18520	COG1028	Short-chain dehydrogenase reductase Sdr
A4U70_RS18535	COG2879	small protein
A4U70_RS18540	COG1966	Carbon starvation protein
A4U70_RS18550	COG1028	Short-chain dehydrogenase reductase Sdr
A4U70_RS18555	COG3433	isochorismatase activity
A4U70_RS18555	COG1535	isochorismatase
A4U70_RS18560	COG1021	2,3-dihydroxybenzoate-AMP ligase
A4U70_RS18565	COG1169	isochorismate synthase
A4U70_RS18570	COG4592	Periplasmic binding protein
A4U70_RS18580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4U70_RS18585	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4U70_RS18590	COG1120	ATPase activity
A4U70_RS18595	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
A4U70_RS18595	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4U70_RS18600	COG3251	PFAM MbtH domain protein
A4U70_RS18605	COG2382	esterase
A4U70_RS18615	COG4771	TonB-dependent receptor
A4U70_RS18620	COG2977	Belongs to the P-Pant transferase superfamily
A4U70_RS18625	COG3958	Transketolase
A4U70_RS18630	COG3959	Transketolase, thiamine diphosphate binding domain
A4U70_RS18640	COG2390	Transcriptional regulator
A4U70_RS18645	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A4U70_RS18650	COG1879	ABC-type sugar transport system periplasmic component
A4U70_RS18660	COG1129	ABC transporter
A4U70_RS18665	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4U70_RS18675	COG1028	Short-chain dehydrogenase reductase Sdr
A4U70_RS18685	COG0583	DNA-binding transcription factor activity
A4U70_RS18690	COG0668	transmembrane transport
A4U70_RS18700	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A4U70_RS18730	COG0747	negative chemotaxis
A4U70_RS18735	COG0601	transmembrane transport
A4U70_RS18740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4U70_RS18745	COG0444	Belongs to the ABC transporter superfamily
A4U70_RS18750	COG4608	Belongs to the ABC transporter superfamily
A4U70_RS18765	COG0656	L-ascorbic acid biosynthetic process
A4U70_RS18785	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A4U70_RS18790	COG4221	oxidoreductase activity
A4U70_RS18800	COG4215	(ABC) transporter
A4U70_RS18805	COG0765	amino acid transport
A4U70_RS18810	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A4U70_RS18825	COG0697	spore germination
A4U70_RS18835	COG3698	Phosphodiester glycosidase
A4U70_RS18880	COG2315	Protein conserved in bacteria
A4U70_RS18885	COG0778	Nitroreductase
A4U70_RS18895	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4U70_RS18905	COG3716	PTS system mannose fructose sorbose family IID component
A4U70_RS18910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A4U70_RS18915	COG2222	sugar isomerase
A4U70_RS18920	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A4U70_RS18920	COG3933	PFAM sigma-54 factor interaction domain-containing protein
A4U70_RS18940	COG0477	Major facilitator Superfamily
A4U70_RS18945	COG0668	transmembrane transport
A4U70_RS18970	COG2211	Major facilitator Superfamily
A4U70_RS18975	COG1113	amino acid transport
A4U70_RS18990	COG1012	belongs to the aldehyde dehydrogenase family
A4U70_RS18995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4U70_RS19005	COG0531	amino acid
A4U70_RS19020	COG4680	protein conserved in bacteria
A4U70_RS19065	COG0667	Aldo Keto reductase
A4U70_RS19070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4U70_RS19075	COG1473	amidohydrolase
A4U70_RS19100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4U70_RS19105	COG1120	ATPase activity
A4U70_RS19110	COG1566	PFAM secretion protein HlyD family protein
A4U70_RS19155	COG4211	Belongs to the binding-protein-dependent transport system permease family
A4U70_RS19160	COG1129	ABC transporter
A4U70_RS19175	COG0673	inositol 2-dehydrogenase activity
A4U70_RS19205	COG3104	oligopeptide transport
A4U70_RS19210	COG1982	Orn Lys Arg decarboxylase major
A4U70_RS19215	COG0531	amino acid
A4U70_RS19220	COG3710	Transcriptional regulator
A4U70_RS19230	COG1560	Kdo2-lipid A biosynthetic process
A4U70_RS19245	COG3188	usher protein
A4U70_RS19250	COG3121	Chaperone
A4U70_RS19255	COG3539	Fimbrial protein
A4U70_RS19425	COG3567	Phage-associated protein, HI1409 family
A4U70_RS19430	COG1783	phage Terminase large subunit
A4U70_RS19440	COG3772	lysozyme
A4U70_RS19640	COG0582	viral genome integration into host DNA
A4U70_RS19660	COG2501	S4 domain
A4U70_RS19670	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A4U70_RS19690	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A4U70_RS19695	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A4U70_RS19710	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
A4U70_RS19715	COG4181	ATPase activity
A4U70_RS19720	COG2755	lipolytic protein G-D-S-L family
A4U70_RS19725	COG0300	oxidoreductase activity
A4U70_RS19730	COG3118	belongs to the thioredoxin family
A4U70_RS19740	COG0390	transport system, permease component
A4U70_RS19745	COG4619	ABC transporter
A4U70_RS19750	COG0330	HflC and HflK could
A4U70_RS19755	COG1585	Membrane protein implicated in regulation of membrane protease activity
A4U70_RS19770	COG3735	TraB family
A4U70_RS19775	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A4U70_RS19785	COG2223	nitrite transmembrane transporter activity
A4U70_RS19790	COG4651	solute:proton antiporter activity
A4U70_RS19790	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A4U70_RS19795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4U70_RS19835	COG2832	Protein of unknown function (DUF454)
A4U70_RS19840	COG3923	Primosomal replication protein n
A4U70_RS19855	COG3264	Mechanosensitive ion channel
A4U70_RS19855	COG1196	nuclear chromosome segregation
A4U70_RS19860	COG1309	transcriptional regulator
A4U70_RS19865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4U70_RS19870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4U70_RS19885	COG0110	maltose O-acetyltransferase activity
A4U70_RS19930	COG1874	Beta-galactosidase
A4U70_RS19935	COG3867	Arabinogalactan endo-beta-1,4-galactanase
A4U70_RS19940	COG3833	ABC-type maltose transport systems, permease component
A4U70_RS19945	COG1175	transmembrane transport
A4U70_RS19950	COG2182	Extracellular solute-binding protein
A4U70_RS19960	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A4U70_RS19975	COG2364	Membrane
A4U70_RS20005	COG3695	enzyme binding
A4U70_RS20010	COG3126	Type III secretion system lipoprotein chaperone (YscW)
A4U70_RS20015	COG1946	Acyl-CoA thioesterase
A4U70_RS20020	COG0004	ammonium transporteR
A4U70_RS20025	COG0347	Belongs to the P(II) protein family
A4U70_RS20030	COG1132	(ABC) transporter
A4U70_RS20035	COG1132	(ABC) transporter
A4U70_RS20040	COG1522	sequence-specific DNA binding
A4U70_RS20055	COG4533	DNA binding
A4U70_RS20065	COG0824	Thioesterase
A4U70_RS20070	COG1555	photosystem II stabilization
A4U70_RS20075	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A4U70_RS20080	COG0776	regulation of translation
A4U70_RS20085	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A4U70_RS20110	COG0271	Belongs to the BolA IbaG family
A4U70_RS20115	COG3056	Lipoprotein
A4U70_RS20120	COG2223	nitrite transmembrane transporter activity
A4U70_RS20125	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A4U70_RS20130	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A4U70_RS20135	COG1845	cytochrome c oxidase, subunit III
A4U70_RS20140	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A4U70_RS20155	COG1414	Transcriptional regulator
A4U70_RS20160	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A4U70_RS20165	COG1053	succinate dehydrogenase
A4U70_RS20190	COG0673	inositol 2-dehydrogenase activity
A4U70_RS20195	COG2814	Major facilitator Superfamily
A4U70_RS20205	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A4U70_RS20210	COG0693	protein deglycase activity
A4U70_RS20230	COG0142	geranyltranstransferase activity
A4U70_RS20240	COG0667	Aldo Keto reductase
A4U70_RS20245	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A4U70_RS20265	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A4U70_RS20265	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A4U70_RS20275	COG4238	major outer membrane lipoprotein
A4U70_RS20295	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4U70_RS20300	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4U70_RS20305	COG1862	Preprotein translocase
A4U70_RS20325	COG0450	alkyl hydroperoxide reductase
A4U70_RS20330	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4U70_RS20345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4U70_RS20355	COG1228	amidohydrolase
A4U70_RS20365	COG1335	isochorismatase
A4U70_RS20370	COG0583	DNA-binding transcription factor activity
A4U70_RS20375	COG0366	Alpha amylase catalytic
A4U70_RS20400	COG0420	3'-5' exonuclease activity
A4U70_RS20405	COG0419	ATPase involved in DNA repair
A4U70_RS20410	COG1940	carbohydrate kinase activity
A4U70_RS20425	COG4126	flavin adenine dinucleotide binding
A4U70_RS20435	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A4U70_RS20440	COG3416	Protein conserved in bacteria
A4U70_RS20450	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A4U70_RS20460	COG1785	Belongs to the alkaline phosphatase family
A4U70_RS20500	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
A4U70_RS20505	COG1335	isochorismatase
A4U70_RS20510	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A4U70_RS20515	COG0113	porphobilinogen synthase activity
A4U70_RS20520	COG1943	Transposase
A4U70_RS20530	COG2175	clavaminate synthase activity
A4U70_RS20535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4U70_RS20540	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
A4U70_RS20545	COG4521	taurine ABC transporter
A4U70_RS20550	COG2040	homocysteine
A4U70_RS20555	COG0833	amino acid
A4U70_RS20565	COG4303	Ethanolamine ammonia lyase large subunit
A4U70_RS20570	COG4302	ethanolamine ammonia-lyase activity
A4U70_RS20605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4U70_RS20610	COG1126	abc transporter atp-binding protein
A4U70_RS20615	COG4597	amino acid ABC transporter
A4U70_RS20620	COG0765	amino acid transport
A4U70_RS20635	COG3188	usher protein
A4U70_RS20660	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
A4U70_RS20670	COG3639	organic phosphonate transmembrane transporter activity
A4U70_RS20695	COG0791	NLP P60 protein
A4U70_RS20720	COG0582	viral genome integration into host DNA
A4U70_RS20755	COG3121	Chaperone
A4U70_RS20760	COG3188	usher protein
A4U70_RS20785	COG2909	trisaccharide binding
A4U70_RS20790	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A4U70_RS20795	COG0022	dehydrogenase e1 component
A4U70_RS20800	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4U70_RS20805	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4U70_RS20830	COG1070	Carbohydrate kinase
A4U70_RS20835	COG1028	Short-chain dehydrogenase reductase Sdr
A4U70_RS20840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4U70_RS20845	COG3775	system Galactitol-specific IIC component
A4U70_RS20850	COG0625	glutathione transferase activity
A4U70_RS20855	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A4U70_RS20875	COG0579	oxidoreductase
A4U70_RS20880	COG1012	belongs to the aldehyde dehydrogenase family
A4U70_RS20885	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A4U70_RS20890	COG1113	amino acid transport
A4U70_RS20895	COG1802	Transcriptional regulator
A4U70_RS20915	COG2195	Cleaves the N-terminal amino acid of tripeptides
A4U70_RS20920	COG0454	-acetyltransferase
A4U70_RS20935	COG2991	Protein conserved in bacteria
A4U70_RS20950	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A4U70_RS20955	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A4U70_RS20975	COG3034	peptidoglycan biosynthetic process
A4U70_RS20980	COG0121	glutamine amidotransferase
A4U70_RS20990	COG1960	acyl-CoA dehydrogenase activity
A4U70_RS20995	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4U70_RS21005	COG0583	DNA-binding transcription factor activity
A4U70_RS21020	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A4U70_RS21030	COG2226	methyltransferase
A4U70_RS21040	COG1388	LysM domain
A4U70_RS21040	COG0741	lytic transglycosylase activity
A4U70_RS21045	COG2226	methyltransferase
A4U70_RS21055	COG2814	Major facilitator Superfamily
A4U70_RS21060	COG0583	DNA-binding transcription factor activity
A4U70_RS21065	COG0656	L-ascorbic acid biosynthetic process
A4U70_RS21100	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A4U70_RS21110	COG2011	ABC-type metal ion transport system permease component
A4U70_RS21115	COG1464	Belongs to the NlpA lipoprotein family
A4U70_RS21125	COG1720	tRNA m6t6A37 methyltransferase activity
A4U70_RS21135	COG0791	NLP P60 protein
A4U70_RS21140	COG3015	lipoprotein NlpE involved in copper resistance
A4U70_RS21145	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A4U70_RS21160	COG4568	rho-dependent transcription termination
A4U70_RS21170	COG0346	lactoylglutathione lyase activity
A4U70_RS21175	COG1982	Orn Lys Arg decarboxylase major
A4U70_RS21185	COG0587	DNA-directed DNA polymerase activity
A4U70_RS21215	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
A4U70_RS21225	COG0750	zinc metalloprotease
A4U70_RS21230	COG0575	Belongs to the CDS family
A4U70_RS21245	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A4U70_RS21275	COG0024	Methionine aminopeptidase
A4U70_RS21280	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A4U70_RS21295	COG3835	regulator
A4U70_RS21300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4U70_RS21320	COG2860	membrane
A4U70_RS21345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4U70_RS21350	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A4U70_RS21355	COG1120	ATPase activity
A4U70_RS21360	COG4774	siderophore transport
A4U70_RS21365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A4U70_RS21460	COG1643	Atp-dependent helicase
A4U70_RS21465	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A4U70_RS21485	COG0617	tRNA 3'-terminal CCA addition
A4U70_RS21490	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A4U70_RS21510	COG0726	polysaccharide deacetylase
A4U70_RS21515	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4U70_RS21520	COG0842	Transport permease protein
A4U70_RS21525	COG1131	(ABC) transporter
A4U70_RS21530	COG0288	reversible hydration of carbon dioxide
A4U70_RS21540	COG4993	Dehydrogenase
A4U70_RS21545	COG2132	Multicopper oxidase
A4U70_RS21585	COG3064	Membrane
A4U70_RS21600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4U70_RS21605	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4U70_RS21610	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A4U70_RS21615	COG2186	Transcriptional regulator
A4U70_RS21620	COG1113	amino acid transport
A4U70_RS21625	COG2211	Major facilitator Superfamily
A4U70_RS21630	COG3940	Belongs to the glycosyl hydrolase 43 family
A4U70_RS21635	COG3725	Membrane protein required for beta-lactamase induction
A4U70_RS21640	COG3023	N-Acetylmuramoyl-L-alanine amidase
A4U70_RS21650	COG4969	Belongs to the N-Me-Phe pilin family
A4U70_RS21655	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A4U70_RS21660	COG1459	type II secretion system
A4U70_RS21685	COG0494	nUDIX hydrolase
A4U70_RS21705	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A4U70_RS21710	COG0849	cell division
A4U70_RS21735	COG0772	Belongs to the SEDS family
A4U70_RS21750	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A4U70_RS21755	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A4U70_RS21760	COG0768	penicillin binding
A4U70_RS21785	COG1609	Transcriptional regulator
A4U70_RS21795	COG0028	Belongs to the TPP enzyme family
A4U70_RS21845	COG0738	Major facilitator superfamily
A4U70_RS21860	COG2271	Major facilitator Superfamily
A4U70_RS21865	COG2814	Major facilitator Superfamily
A4U70_RS21885	COG1178	ABC-type Fe3 transport system permease component
A4U70_RS21895	COG0586	Pfam SNARE associated Golgi protein
A4U70_RS21915	COG0235	Class ii aldolase
A4U70_RS21920	COG0417	DNA replication proofreading
A4U70_RS21930	COG0564	pseudouridine synthase activity
A4U70_RS21945	COG3493	citrate carrier protein
A4U70_RS21960	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A4U70_RS21965	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A4U70_RS21975	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A4U70_RS22030	COG0505	Belongs to the CarA family
A4U70_RS22045	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A4U70_RS22055	COG3152	Membrane
A4U70_RS22070	COG1047	Peptidyl-prolyl cis-trans
A4U70_RS22085	COG0196	riboflavin kinase activity
A4U70_RS22105	COG0583	DNA-binding transcription factor activity
A4U70_RS22130	COG4735	regulation of single-species biofilm formation
A4U70_RS22135	COG1584	GPR1 FUN34 yaaH family protein
A4U70_RS22140	COG0477	Major facilitator Superfamily
A4U70_RS22145	COG0521	Mo-molybdopterin cofactor biosynthetic process
A4U70_RS22150	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A4U70_RS22155	COG1115	amino acid carrier protein
A4U70_RS22170	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A4U70_RS22180	COG0527	aspartate kinase activity
A4U70_RS22180	COG0460	homoserine dehydrogenase
A4U70_RS22190	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A4U70_RS22200	COG0745	RESPONSE REGULATOR receiver
A4U70_RS22205	COG4452	Inner membrane protein CreD
A4U70_RS22210	COG2205	protein histidine kinase activity
A4U70_RS22215	COG0745	RESPONSE REGULATOR receiver
A4U70_RS22220	COG3045	CreA protein
A4U70_RS22225	COG2207	Transcriptional regulator
A4U70_RS22225	COG3708	Transcriptional regulator
A4U70_RS22245	COG0741	lytic transglycosylase activity
A4U70_RS22255	COG0488	(ABC) transporter
A4U70_RS22265	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A4U70_RS22270	COG0560	Phosphoserine phosphatase
A4U70_RS22280	COG3726	membrane protein affecting hemolysin expression
A4U70_RS22310	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A4U70_RS22315	COG0084	hydrolase, TatD family'
A4U70_RS22320	COG4667	esterase of the alpha-beta hydrolase superfamily
A4U70_RS22330	COG2823	Periplasmic or secreted lipoprotein
A4U70_RS22340	COG1011	Hydrolase
A4U70_RS22345	COG0456	acetyltransferase
A4U70_RS22350	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
A4U70_RS22380	COG3706	GGDEF domain
A4U70_RS22385	COG4114	ferric iron reductase
A4U70_RS22390	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A4U70_RS22390	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A4U70_RS22395	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A4U70_RS22400	COG2197	response regulator
A4U70_RS22405	COG2197	response regulator
A4U70_RS22425	COG2966	Psort location CytoplasmicMembrane, score
A4U70_RS22440	COG1484	DNA-dependent DNA replication
A4U70_RS22455	COG5464	transposase or invertase
A4U70_RS22465	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A4U70_RS22470	COG3716	PTS system mannose fructose sorbose family IID component
A4U70_RS22475	COG3715	PTS system
A4U70_RS22490	COG3933	PFAM sigma-54 factor interaction domain-containing protein
A4U70_RS22490	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A4U70_RS22495	COG1214	PFAM Peptidase M22, glycoprotease
A4U70_RS22495	COG0456	acetyltransferase
A4U70_RS22505	COG1737	Transcriptional regulator
A4U70_RS22510	COG0800	Aldolase
A4U70_RS22515	COG3734	2-keto-3-deoxy-galactonokinase
A4U70_RS22520	COG4145	pantothenate transmembrane transporter activity
A4U70_RS22530	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
A4U70_RS22550	COG0531	amino acid
A4U70_RS22555	COG1012	belongs to the aldehyde dehydrogenase family
A4U70_RS22560	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4U70_RS22575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4U70_RS22575	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A4U70_RS22590	COG1846	Transcriptional regulator
A4U70_RS22595	COG0179	Fumarylacetoacetate (FAA) hydrolase
A4U70_RS22605	COG1012	belongs to the aldehyde dehydrogenase family
A4U70_RS22610	COG3384	dioxygenase
A4U70_RS22620	COG3971	2-oxopent-4-enoate hydratase activity
A4U70_RS22640	COG2368	4-hydroxyphenylacetate
A4U70_RS22645	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A4U70_RS22650	COG1966	Carbon starvation protein
A4U70_RS22655	COG2879	small protein
A4U70_RS22660	COG0523	cobalamin synthesis protein
A4U70_RS22670	COG1012	belongs to the aldehyde dehydrogenase family
A4U70_RS22675	COG5464	transposase or invertase
A4U70_RS22680	COG1917	Cupin 2, conserved barrel domain protein
A4U70_RS22680	COG2207	Transcriptional regulator
A4U70_RS22690	COG2733	membrane
A4U70_RS22705	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
A4U70_RS22710	COG1924	4 iron, 4 sulfur cluster binding
A4U70_RS22725	COG1566	PFAM secretion protein HlyD family protein
A4U70_RS22735	COG5457	Domain of unknown function (DUF1127)
A4U70_RS22740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4U70_RS22755	COG0583	DNA-binding transcription factor activity
A4U70_RS22760	COG2249	NAD(P)H dehydrogenase (quinone) activity
A4U70_RS22770	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4U70_RS22775	COG1129	ABC transporter
A4U70_RS22780	COG1879	ABC-type sugar transport system periplasmic component
A4U70_RS22790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4U70_RS22795	COG1129	ABC transporter
A4U70_RS22795	COG0842	Transport permease protein
A4U70_RS22800	COG0842	Transport permease protein
A4U70_RS22835	COG2850	peptidyl-arginine hydroxylation
A4U70_RS22850	COG5002	protein histidine kinase activity
A4U70_RS22855	COG0745	RESPONSE REGULATOR receiver
A4U70_RS22865	COG1538	Outer membrane efflux protein
A4U70_RS22870	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4U70_RS22875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4U70_RS22880	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4U70_RS22890	COG3040	lipid binding
A4U70_RS22895	COG0789	Transcriptional regulator
A4U70_RS22905	COG0300	oxidoreductase activity
A4U70_RS22920	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A4U70_RS22940	COG3272	Protein of unknown function (DUF1722)
A4U70_RS22945	COG4580	involved in the transport of maltose and maltodextrins
A4U70_RS22950	COG2115	Belongs to the xylose isomerase family
A4U70_RS22955	COG2211	Major facilitator Superfamily
A4U70_RS22960	COG3507	Belongs to the glycosyl hydrolase 43 family
A4U70_RS22980	COG1216	Glycosyl transferase, family 2
A4U70_RS22985	COG2801	Transposase and inactivated derivatives
A4U70_RS23030	COG1752	Esterase of the alpha-beta hydrolase superfamily
A4U70_RS23055	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A4U70_RS23120	COG0582	viral genome integration into host DNA
A4U70_RS23130	COG0288	reversible hydration of carbon dioxide
A4U70_RS23140	COG1064	alcohol dehydrogenase
A4U70_RS23145	COG1175	transmembrane transport
A4U70_RS23150	COG0395	ABC-type sugar transport system, permease component
A4U70_RS23155	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A4U70_RS23160	COG3842	ATPase activity
A4U70_RS23175	COG1082	Xylose isomerase domain protein TIM barrel
A4U70_RS23185	COG3962	Belongs to the TPP enzyme family
A4U70_RS23190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4U70_RS23195	COG1737	Transcriptional regulator
A4U70_RS23195	COG0837	glucose binding
A4U70_RS23210	COG3718	enzyme involved in inositol metabolism
A4U70_RS23225	COG0433	COG0433 Predicted ATPase
A4U70_RS23230	COG0795	lipopolysaccharide-transporting ATPase activity
A4U70_RS23235	COG0795	lipopolysaccharide-transporting ATPase activity
A4U70_RS23250	COG2927	DNA polymerase III (CHI subunit)
A4U70_RS23255	COG0525	valine-tRNA ligase activity
A4U70_RS23280	COG2188	Transcriptional regulator
A4U70_RS23285	COG1288	antiporter activity
A4U70_RS23290	COG1228	amidohydrolase
A4U70_RS23295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4U70_RS23300	COG2222	sugar isomerase
A4U70_RS23305	COG2731	YhcH YjgK YiaL family protein
A4U70_RS23345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4U70_RS23345	COG1263	PTS System
A4U70_RS23350	COG0366	Alpha amylase catalytic
A4U70_RS23355	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A4U70_RS23380	COG0602	queuosine metabolic process
A4U70_RS23385	COG2026	Addiction module toxin, RelE StbE family
A4U70_RS23390	COG3077	Addiction module antitoxin, RelB DinJ family
A4U70_RS23395	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4U70_RS23395	COG3711	transcriptional antiterminator
A4U70_RS23400	COG2706	6-phosphogluconolactonase activity
A4U70_RS23415	COG3964	amidohydrolase
A4U70_RS23450	COG0312	modulator of DNA gyrase
A4U70_RS23470	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A4U70_RS23480	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4U70_RS23485	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4U70_RS23490	COG1129	ABC transporter
A4U70_RS23495	COG1879	ABC-type sugar transport system periplasmic component
A4U70_RS23515	COG2105	PFAM AIG2 family protein
A4U70_RS23520	COG2911	Protein conserved in bacteria
A4U70_RS23525	COG0729	surface antigen
A4U70_RS23535	COG1253	flavin adenine dinucleotide binding
A4U70_RS23560	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
A4U70_RS23575	COG1733	regulation of RNA biosynthetic process
A4U70_RS23580	COG0702	epimerase
A4U70_RS23590	COG0697	spore germination
A4U70_RS23600	COG1113	amino acid transport
A4U70_RS23605	COG0545	Peptidyl-prolyl cis-trans isomerase
A4U70_RS23610	COG3061	Opacity-associated protein A
A4U70_RS23620	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A4U70_RS23625	COG2965	DNA replication, synthesis of RNA primer
A4U70_RS23685	COG1073	alpha beta
A4U70_RS23690	COG3650	response to hydrogen peroxide
A4U70_RS23700	COG1960	acyl-CoA dehydrogenase activity
A4U70_RS23705	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4U70_RS23710	COG0557	exoribonuclease II activity
A4U70_RS23725	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
A4U70_RS23735	COG0330	HflC and HflK could
A4U70_RS23740	COG0330	HflC and HflK could
A4U70_RS23745	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A4U70_RS23765	COG0860	N-Acetylmuramoyl-L-alanine amidase
A4U70_RS23770	COG0802	atpase or kinase
A4U70_RS23775	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A4U70_RS23775	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A4U70_RS23780	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A4U70_RS23805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4U70_RS23830	COG1511	domain protein
A4U70_RS23830	COG3264	Mechanosensitive ion channel
A4U70_RS23845	COG1053	succinate dehydrogenase
A4U70_RS23850	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A4U70_RS23870	COG2076	Multidrug Resistance protein
A4U70_RS23875	COG5510	response to toxic substance
A4U70_RS23890	COG1509	lysine 2,3-aminomutase activity
A4U70_RS23955	COG0531	amino acid
A4U70_RS23960	COG3030	protein affecting phage T7 exclusion by the F plasmid
A4U70_RS23970	COG1027	Aspartate ammonia-lyase
A4U70_RS23975	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A4U70_RS23990	COG1309	transcriptional regulator
A4U70_RS24015	COG0457	Tetratricopeptide repeat
A4U70_RS24020	COG0726	polysaccharide deacetylase
A4U70_RS24020	COG1649	PFAM Uncharacterised BCR, COG1649
A4U70_RS24025	COG1215	transferase activity, transferring glycosyl groups
A4U70_RS24045	COG0861	Integral membrane protein TerC family
A4U70_RS24075	COG1486	melibiose metabolic process
A4U70_RS24085	COG2169	Transcriptional regulator
A4U70_RS24100	COG2824	Alkylphosphonate utilization operon protein PhnA
A4U70_RS24105	COG2764	glyoxalase bleomycin resistance protein dioxygenase
A4U70_RS24110	COG2188	Transcriptional regulator
A4U70_RS24115	COG3624	Phosphonate C-P lyase system protein PhnG
A4U70_RS24120	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
A4U70_RS24125	COG3626	phosphonate metabolism
A4U70_RS24130	COG3627	carbon phosphorus lyase activity
A4U70_RS24135	COG4107	phosphonate C-P lyase system protein PhnK
A4U70_RS24140	COG4778	phosphonate C-P lyase system protein PhnL
A4U70_RS24145	COG3454	Phosphonate metabolism
A4U70_RS24155	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A4U70_RS24165	COG0784	Response regulator, receiver
A4U70_RS24165	COG4191	Histidine kinase
A4U70_RS24170	COG1129	ABC transporter
A4U70_RS24175	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4U70_RS24210	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
A4U70_RS24215	COG1301	dicarboxylic acid transport
A4U70_RS24235	COG3162	membrane
A4U70_RS24265	COG3539	Fimbrial protein
A4U70_RS24270	COG1346	cytolysis
A4U70_RS24275	COG1380	Effector of murein hydrolase LrgA
A4U70_RS24280	COG0583	DNA-binding transcription factor activity
A4U70_RS24285	COG0025	NhaP-type Na H and K H
A4U70_RS24290	COG2252	PERMEase
A4U70_RS24300	COG0625	glutathione transferase activity
A4U70_RS24305	COG0789	Transcriptional regulator
A4U70_RS24315	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A4U70_RS24345	COG3842	ATPase activity
A4U70_RS24350	COG1234	tRNA 3'-trailer cleavage
A4U70_RS24355	COG1609	Transcriptional regulator
A4U70_RS24360	COG0483	inositol monophosphate 1-phosphatase activity
A4U70_RS24375	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A4U70_RS24395	COG4771	TonB-dependent receptor
A4U70_RS24400	COG0741	lytic transglycosylase activity
A4U70_RS24415	COG2315	Protein conserved in bacteria
A4U70_RS24420	COG0432	Pfam Uncharacterised protein family UPF0047
A4U70_RS24435	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A4U70_RS24440	COG0305	Participates in initiation and elongation during chromosome replication
A4U70_RS24455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A4U70_RS24465	COG0735	belongs to the Fur family
A4U70_RS24470	COG3237	CsbD-like
A4U70_RS24475	COG0534	Mate efflux family protein
A4U70_RS24485	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A4U70_RS24560	COG0251	oxidation-reduction process
A4U70_RS24570	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A4U70_RS24585	COG0527	aspartate kinase activity
A4U70_RS24640	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A4U70_RS24670	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A4U70_RS24680	COG0456	acetyltransferase
A4U70_RS24715	COG0151	Belongs to the GarS family
A4U70_RS24725	COG4191	Histidine kinase
A4U70_RS24730	COG3678	ATP-independent chaperone mediated protein folding
A4U70_RS24765	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
A4U70_RS24780	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A4U70_RS24785	COG2104	thiamine diphosphate biosynthetic process
A4U70_RS24805	COG3706	GGDEF domain
A4U70_RS24815	COG1447	Phosphotransferase system cellobiose-specific component IIA
A4U70_RS24820	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A4U70_RS24860	COG0250	Participates in transcription elongation, termination and antitermination
A4U70_RS24940	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
A4U70_RS24950	COG1739	Uncharacterized protein family UPF0029
A4U70_RS24995	COG0805	protein transport
A4U70_RS25015	COG3165	ubiquinone biosynthetic process from chorismate
A4U70_RS25045	COG0583	DNA-binding transcription factor activity
A4U70_RS25050	COG0697	spore germination
A4U70_RS25055	COG0561	phosphatase activity
A4U70_RS25060	COG2267	carboxylic ester hydrolase activity
A4U70_RS25065	COG1280	lysine exporter protein (LysE YggA)
A4U70_RS25075	COG1280	lysine exporter protein (LysE YggA)
A4U70_RS25110	COG0210	DNA helicase
A4U70_RS25115	COG1011	Hydrolase
A4U70_RS25160	COG2959	enzyme of heme biosynthesis
A4U70_RS25165	COG3071	HemY protein
A4U70_RS25210	COG2244	polysaccharide biosynthetic process
A4U70_RS25215	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A4U70_RS25220	COG0456	acetyltransferase
A4U70_RS25225	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A4U70_RS25230	COG1088	dTDP-glucose 4,6-dehydratase activity
A4U70_RS25235	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A4U70_RS25240	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A4U70_RS25250	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A4U70_RS25255	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A4U70_RS25265	COG3118	belongs to the thioredoxin family
A4U70_RS25295	COG1811	Na channel or pump
A4U70_RS25305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A4U70_RS25310	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A4U70_RS25320	COG0583	DNA-binding transcription factor activity
A4U70_RS25325	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A4U70_RS25340	COG3978	acetolactate synthase activity
A4U70_RS25360	COG3085	chromosome segregation
A4U70_RS25435	COG0583	DNA-binding transcription factor activity
A4U70_RS25460	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A4U70_RS25475	COG3443	Belongs to the bacterial solute-binding protein 9 family
A4U70_RS25480	COG2207	Transcriptional regulator
A4U70_RS25490	COG0371	Dehydrogenase
A4U70_RS25495	COG0697	spore germination
A4U70_RS25505	COG0583	DNA-binding transcription factor activity
A4U70_RS25515	COG0737	Belongs to the 5'-nucleotidase family
A4U70_RS25525	COG0460	homoserine dehydrogenase
A4U70_RS25525	COG0527	aspartate kinase activity
A4U70_RS25530	COG0626	cystathionine gamma-synthase activity
A4U70_RS25545	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A4U70_RS25550	COG1609	Transcriptional regulator
A4U70_RS25555	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A4U70_RS25570	COG1575	Belongs to the MenA family. Type 1 subfamily
A4U70_RS25590	COG3678	ATP-independent chaperone mediated protein folding
A4U70_RS25595	COG0745	RESPONSE REGULATOR receiver
A4U70_RS25600	COG2205	protein histidine kinase activity
A4U70_RS25605	COG2258	MOSC domain
A4U70_RS25610	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A4U70_RS25655	COG1129	ABC transporter
A4U70_RS25660	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4U70_RS25665	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4U70_RS25670	COG1454	alcohol dehydrogenase
A4U70_RS25680	COG2211	Major facilitator Superfamily
A4U70_RS25725	COG3383	formate dehydrogenase (NAD+) activity
A4U70_RS25725	COG0243	molybdopterin cofactor binding
A4U70_RS25730	COG0243	molybdopterin cofactor binding
A4U70_RS25730	COG3383	formate dehydrogenase (NAD+) activity
A4U70_RS25735	COG0437	4 iron, 4 sulfur cluster binding
A4U70_RS25740	COG2864	formate dehydrogenase
A4U70_RS25755	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A4U70_RS25760	COG0657	acetylesterase activity
A4U70_RS25765	COG0456	acetyltransferase
A4U70_RS25780	COG1011	Hydrolase
A4U70_RS25800	COG3852	Histidine kinase
A4U70_RS25810	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A4U70_RS25835	COG0204	Acyl-transferase
A4U70_RS25845	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A4U70_RS25850	COG3084	Protein conserved in bacteria
A4U70_RS25860	COG1763	Mo-molybdopterin cofactor biosynthetic process
A4U70_RS25890	COG2186	Transcriptional regulator
A4U70_RS25895	COG0477	Major facilitator Superfamily
A4U70_RS25900	COG1609	Transcriptional regulator
A4U70_RS25905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4U70_RS25915	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4U70_RS25920	COG1129	ABC transporter
A4U70_RS25950	COG1522	sequence-specific DNA binding
A4U70_RS25955	COG0716	FMN binding
A4U70_RS25975	COG3312	ion transport
A4U70_RS26025	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A4U70_RS26030	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A4U70_RS26035	COG0573	inorganic phosphate transmembrane transporter activity
A4U70_RS26040	COG0581	inorganic phosphate transmembrane transporter activity
A4U70_RS26045	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A4U70_RS26050	COG0704	Plays a role in the regulation of phosphate uptake
A4U70_RS26060	COG2382	esterase
A4U70_RS26065	COG0363	glucosamine-6-phosphate deaminase activity
A4U70_RS26070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4U70_RS26080	COG2252	PERMEase
A4U70_RS26085	COG0431	NADPH-dependent FMN reductase
A4U70_RS26090	COG2091	lysine biosynthetic process via aminoadipic acid
A4U70_RS26120	COG0759	Could be involved in insertion of integral membrane proteins into the membrane