locus-tag class description D0S46_RS00025 ENOG4105NI3 Protein of unknown function (DUF3237) D0S46_RS00035 ENOG4105CT4 transporter D0S46_RS00040 ENOG4105CJQ hydrolase, family 31 D0S46_RS00050 ENOG4105F8D glycoside hydrolase family 4 D0S46_RS00055 ENOG4105CI1 PTS System D0S46_RS00060 ENOG4105JV1 AsmA family D0S46_RS00065 ENOG4105C2W permease D0S46_RS00070 ENOG4105D6U Sodium Glutamate Symporter D0S46_RS00075 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) D0S46_RS00080 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) D0S46_RS00085 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) D0S46_RS00090 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein D0S46_RS00105 ENOG4105CP7 Triose-phosphate isomerase D0S46_RS00110 ENOG4105EBK exported protein D0S46_RS00115 ENOG4108VTS Membrane D0S46_RS00120 ENOG4105DP0 ferredoxin-NADP reductase D0S46_RS00125 ENOG4105CBT Fructose-1,6-bisphosphatase D0S46_RS00130 ENOG4105CB5 ATP-dependent DNA helicase recG D0S46_RS00135 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase D0S46_RS00140 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) D0S46_RS00150 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) D0S46_RS00155 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) D0S46_RS00160 ENOG4105EN6 Membrane D0S46_RS00170 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) D0S46_RS00175 ENOG4108JZP Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate (By similarity) D0S46_RS00180 ENOG4105DSJ YicC domain protein D0S46_RS00200 ENOG4105CJ1 ABC, transporter D0S46_RS00205 ENOG4107QWP ABC-2 type transporter D0S46_RS00210 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) D0S46_RS00225 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) D0S46_RS00230 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) D0S46_RS00235 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase D0S46_RS00240 ENOG4105W5Q DNA repair protein (RadC D0S46_RS00245 ENOG4105KDC 50s ribosomal protein l28 D0S46_RS00250 ENOG4105W0E 50S ribosomal protein L33 D0S46_RS00255 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) D0S46_RS00260 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) D0S46_RS00265 ENOG4106WTF Glycosyl transferase, family 2 D0S46_RS00270 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase D0S46_RS00275 ENOG4105K64 Glycosyl transferase, family 2 D0S46_RS00280 ENOG4105CPK Glycosyl transferase (Group 1 D0S46_RS00290 ENOG4105DKP glycosyl transferase, family 9 D0S46_RS00315 ENOG4105D16 lipopolysaccharide heptosyltransferase i D0S46_RS00320 ENOG4105XA0 heptosyltransferase ii D0S46_RS00325 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) D0S46_RS00330 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) D0S46_RS00335 ENOG4105CPQ Dehydrogenase D0S46_RS00340 ENOG4106WTF Glycosyl transferase, family 2 D0S46_RS00345 ENOG4105PXI polysaccharide deacetylase D0S46_RS00350 ENOG41063SB peptidase D0S46_RS00360 ENOG4107YZP Rhodanese domain protein D0S46_RS00365 ENOG4105VW4 glutaredoxin 3 D0S46_RS00370 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) D0S46_RS00375 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase D0S46_RS00380 ENOG4105D7W serine acetyltransferase D0S46_RS00385 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) D0S46_RS00390 ENOG4105DMF Dehydrogenase D0S46_RS00395 ENOG41073TP transcriptional regulator D0S46_RS00400 ENOG4105DAA L-lactate D0S46_RS00405 ENOG4108YYI Protein of unknown function (DUF2810) D0S46_RS00415 ENOG4105E61 Mannitol repressor protein D0S46_RS00425 ENOG4105CTS PTS system mannitol-specific D0S46_RS00435 ENOG4108U78 Glutathione S-transferase D0S46_RS00440 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) D0S46_RS00445 ENOG4105EM7 Selenocysteine-specific translation elongation factor D0S46_RS00450 ENOG4105J4Q Transcriptional regulator D0S46_RS00455 ENOG4108RC0 Electron transport protein D0S46_RS00460 ENOG4105JKW Valine--pyruvate aminotransferase D0S46_RS00465 ENOG4107T9C Alpha amylase catalytic region D0S46_RS00475 ENOG4108UR8 BAX protein D0S46_RS00480 ENOG4105T16 Transcriptional regulator (AraC family) D0S46_RS00485 ENOG4108HWW ABC transporter D0S46_RS00495 ENOG4105DFW ABC transporter D0S46_RS00505 ENOG4105C93 Xylose Isomerase D0S46_RS00510 ENOG4105CMG Carbohydrate kinase D0S46_RS00515 ENOG410688U Inner membrane protein yiaB D0S46_RS00520 ENOG4108Z12 YiaAB two helix domain-containing protein D0S46_RS00525 ENOG4105MEV Acyl-transferase D0S46_RS00540 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit D0S46_RS00545 ENOG4105C38 Glycyl-tRNA synthetase beta subunit D0S46_RS00555 ENOG41060TC Hok gef cell toxic protein D0S46_RS00570 ENOG4105MVF Transcriptional regulator D0S46_RS00575 ENOG4105D2S major facilitator superfamily D0S46_RS00585 ENOG4106JH6 (LipO)protein D0S46_RS00590 ENOG4105C5I Dehydrogenase D0S46_RS00600 ENOG4105D7K pfkb domain protein D0S46_RS00610 ENOG4108M60 Transcriptional regulator D0S46_RS00615 ENOG4108ZG0 Ompa motb domain protein D0S46_RS00620 ENOG4107QY8 reductase D0S46_RS00625 ENOG4105HNP -acetyltransferase D0S46_RS00630 ENOG4108R3E Dna-3-methyladenine glycosylase i D0S46_RS00635 ENOG4105EAX Putative lipase D0S46_RS00640 ENOG4105FCD Major Facilitator D0S46_RS00645 ENOG4105DIJ Phosphoethanolamine transferase D0S46_RS00670 ENOG4105DEF Extracellular solute-binding protein, family 5 D0S46_RS00675 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component D0S46_RS00680 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D0S46_RS00685 ENOG4105C3U ABC transporter D0S46_RS00690 ENOG4108JQ7 (ABC) transporter D0S46_RS00705 ENOG4107U53 septum site-determining protein minD D0S46_RS00715 ENOG4107EEX Cellulose synthase regulator protein D0S46_RS00720 ENOG4105EJG cellulose synthase D0S46_RS00735 ENOG4105D1V cellulose synthase operon protein YhjU D0S46_RS00740 ENOG410675P Celllulose biosynthesis operon protein BcsF YhjT D0S46_RS00745 ENOG4105U74 cellulose biosynthesis protein BcsE D0S46_RS00750 ENOG410661M cytoplasmic protein D0S46_RS00755 ENOG4105UTS cellulose synthase operon protein YhjQ D0S46_RS00760 ENOG4107QZ7 Cellulose synthase catalytic subunit D0S46_RS00765 ENOG4107EEX Cellulose synthase regulator protein D0S46_RS00770 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) D0S46_RS00775 ENOG4105EJG cellulose synthase D0S46_RS00780 ENOG4105BZU Histidine kinase D0S46_RS00795 ENOG4105CS0 peptidase D0S46_RS00810 ENOG41066T0 asmA family D0S46_RS00815 ENOG4105CSH Transporter D0S46_RS00820 ENOG4107H3J ribonuclease D0S46_RS00825 ENOG4105CBN LysR family transcriptional regulator D0S46_RS00830 ENOG4105CHR reductase D0S46_RS00845 ENOG4105C0A alcohol dehydrogenase D0S46_RS00855 ENOG4105DC8 reductase D0S46_RS00860 ENOG4105D6S protein involved in catabolism of external DNA D0S46_RS00865 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase D0S46_RS00870 ENOG4105DGW oligopeptidase A D0S46_RS00875 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) D0S46_RS00880 ENOG4105DUX Transporter D0S46_RS00890 ENOG4108V6B universal stress protein B D0S46_RS00895 ENOG4105CJ3 phosphate transporter D0S46_RS00900 ENOG4105CBX hi0933 family D0S46_RS00925 ENOG4105E5H Transposase D0S46_RS00930 ENOG4108YXQ IS66 Orf2 family protein D0S46_RS00950 ENOG4105DZR Type I site-specific deoxyribonuclease D0S46_RS00955 ENOG4105ESI atpase involved in dna repair D0S46_RS00960 ENOG4105CB5 ATP-dependent DNA helicase recG D0S46_RS00985 ENOG4105CJW magnesium transporter D0S46_RS01000 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) D0S46_RS01010 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D0S46_RS01015 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component D0S46_RS01020 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein D0S46_RS01035 ENOG4105PY6 Phenolic acid decarboxylase D0S46_RS01040 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase D0S46_RS01045 ENOG4105CKK Glycosyl transferase, family 2 D0S46_RS01050 ENOG4105C3I Nad-dependent epimerase dehydratase D0S46_RS01055 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) D0S46_RS01060 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) D0S46_RS01065 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) D0S46_RS01070 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) D0S46_RS01075 ENOG4105DSF transport protein D0S46_RS01080 ENOG4105F9N Major Facilitator Superfamily D0S46_RS01085 ENOG4108W1V Lipoprotein D0S46_RS01090 ENOG4105EX9 Membrane D0S46_RS01095 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) D0S46_RS01105 ENOG4107FS9 Membrane D0S46_RS01115 ENOG4105MG3 Membrane D0S46_RS01120 ENOG4106H78 methyltransferase D0S46_RS01125 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) D0S46_RS01130 ENOG4105CAK Cell division ATP-binding protein ftsE D0S46_RS01135 ENOG4105CRP Part of the ABC transporter FtsEX involved in D0S46_RS01150 ENOG4108JPW Aminotransferase D0S46_RS01155 ENOG4105EQR Transposase IS116 IS110 IS902 D0S46_RS01165 ENOG4105CP9 extracellular ligand-binding receptor D0S46_RS01170 ENOG4105U59 -acetyltransferase D0S46_RS01180 ENOG4105CP9 extracellular ligand-binding receptor D0S46_RS01185 ENOG4105C32 Amino acid ABC transporter (Permease) D0S46_RS01190 ENOG4105CF8 branched-chain amino acid ABC transporter, permease D0S46_RS01195 ENOG4105C0Z ABC transporter D0S46_RS01200 ENOG4108IV0 ABC, transporter D0S46_RS01205 ENOG41060M8 Pfam:PhdYeFM D0S46_RS01215 ENOG4105BZ7 extracellular solute-binding protein family 1 D0S46_RS01220 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component D0S46_RS01235 ENOG4107T6V glycerophosphoryl diester phosphodiesterase D0S46_RS01240 ENOG4105WC8 Conserved Protein D0S46_RS01245 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) D0S46_RS01250 ENOG4105WCN acetyltransferase D0S46_RS01260 ENOG4105D9R oxidoreductase D0S46_RS01265 ENOG4105C2I pirin domain protein D0S46_RS01270 ENOG4105DIQ Transcriptional regulator D0S46_RS01275 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family D0S46_RS01280 ENOG4105C6Z Gluconate D0S46_RS01290 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) D0S46_RS01295 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) D0S46_RS01300 ENOG4108IUM Glycogen debranching enzyme D0S46_RS01305 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) D0S46_RS01310 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) D0S46_RS01315 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) D0S46_RS01320 ENOG4105C6V Glycerol-3-phosphate dehydrogenase D0S46_RS01325 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) D0S46_RS01330 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) D0S46_RS01335 ENOG4105E98 transcriptional regulator DeoR family D0S46_RS01340 ENOG41061ZR Transcriptional regulator D0S46_RS01350 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) D0S46_RS01355 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) D0S46_RS01360 ENOG4105C6Z Gluconate D0S46_RS01365 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) D0S46_RS01370 ENOG4105MJ2 Competence protein D0S46_RS01375 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) D0S46_RS01385 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) D0S46_RS01390 ENOG4105CE1 Ferrous iron transport protein b D0S46_RS01395 ENOG4105XFK Ferrous iron transport protein A D0S46_RS01400 ENOG4105BZM domain protein D0S46_RS01405 ENOG4108RRZ Transcription elongation factor GreB D0S46_RS01415 ENOG4105E0F Histidine kinase D0S46_RS01430 ENOG4105VEJ Heat shock protein D0S46_RS01435 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 D0S46_RS01440 ENOG4105DQY intracellular growth attenuator D0S46_RS01445 ENOG4107RK2 ADP-ribose diphosphatase NudE D0S46_RS01450 ENOG4108JQC penicillin-binding protein 1A D0S46_RS01475 ENOG4105E4G Type IV pilus D0S46_RS01485 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) D0S46_RS01490 ENOG4105D49 3-dehydroquinate synthase D0S46_RS01495 ENOG4105EGB membrane protein DamX D0S46_RS01500 ENOG4105DFE Dna adenine methylase D0S46_RS01505 ENOG4105DJV ribulose-phosphate 3-epimerase D0S46_RS01515 ENOG4105C31 Tryptophanyl-tRNA synthetase D0S46_RS01520 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) D0S46_RS01525 ENOG4105WZK nitrite reductase NADPH small subunit D0S46_RS01530 ENOG4107QZF nitrite reductase NADPH large subunit D0S46_RS01535 ENOG4105DZC cytosine deaminase D0S46_RS01540 ENOG4106DTQ Protein TsgA homolog D0S46_RS01545 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) D0S46_RS01550 ENOG4106195 uncharacterized protein yhfG D0S46_RS01555 ENOG4105MZU cell filamentation protein D0S46_RS01565 ENOG4105C8Y Acetylornithine aminotransferase D0S46_RS01570 ENOG410613R integral membrane protein, YccS YhfK family D0S46_RS01575 ENOG4107RYR Transcriptional regulator, Crp Fnr family D0S46_RS01585 ENOG4108UKZ OsmC family D0S46_RS01590 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) D0S46_RS01600 ENOG4105DNZ Alpha Beta Hydrolase D0S46_RS01610 ENOG4105C5H ABC transporter D0S46_RS01620 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein D0S46_RS01630 ENOG4105VKU nucleicacid-binding protein D0S46_RS01635 ENOG4108YZY peptidylprolyl cis-trans isomerase D0S46_RS01640 ENOG4105VRX Protein slyX homolog D0S46_RS01645 ENOG4108V1T peptidylprolyl cis-trans isomerase D0S46_RS01650 ENOG4105WWK YheO domain protein D0S46_RS01655 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) D0S46_RS01660 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) D0S46_RS01665 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) D0S46_RS01670 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) D0S46_RS01675 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) D0S46_RS01680 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) D0S46_RS01685 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) D0S46_RS01695 ENOG4105W53 bacterioferritin-associated ferredoxin D0S46_RS01700 ENOG4108UQY Iron-storage protein D0S46_RS01715 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) D0S46_RS01720 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) D0S46_RS01730 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity D0S46_RS01735 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) D0S46_RS01740 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) D0S46_RS01745 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) D0S46_RS01750 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) D0S46_RS01755 ENOG41083MP 50s ribosomal protein l29 D0S46_RS01760 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal D0S46_RS01765 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) D0S46_RS01770 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) D0S46_RS01785 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) D0S46_RS01790 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) D0S46_RS01800 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) D0S46_RS01805 ENOG4105VPB 50S ribosomal protein L30 D0S46_RS01810 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) D0S46_RS01815 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) D0S46_RS01820 ENOG41067V7 50S ribosomal protein L36 D0S46_RS01825 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits D0S46_RS01830 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) D0S46_RS01835 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) D0S46_RS01840 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) D0S46_RS01845 ENOG4108ZT0 50S ribosomal protein l17 D0S46_RS01850 ENOG4105VTS DnaJ-like, subfamily C D0S46_RS01855 ENOG4105W1Y Transcriptional regulator D0S46_RS01860 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system D0S46_RS01865 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) D0S46_RS01870 ENOG4105C1A potassium transporter peripheral membrane D0S46_RS01875 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B D0S46_RS01880 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) D0S46_RS01885 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) D0S46_RS01890 ENOG4105C79 DNA protecting protein DprA D0S46_RS01900 ENOG4108WI1 Dna topoisomerase D0S46_RS01905 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) D0S46_RS01910 ENOG4105E2X shikimate dehydrogenase D0S46_RS01915 ENOG4105SG3 Protein of unknown function (DUF1488) D0S46_RS01920 ENOG4108Z0R Transferase D0S46_RS01955 ENOG4105XCM membrane LIPOPROTEIN D0S46_RS01960 ENOG4105BZS acriflavin resistance protein D0S46_RS01965 ENOG4105C1P efflux transporter, rnd family, mfp subunit D0S46_RS01970 ENOG4108XG4 DNA-binding transcriptional regulator D0S46_RS01980 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) D0S46_RS01990 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) D0S46_RS01995 ENOG4108IA2 Sodium pantothenate symporter D0S46_RS02000 ENOG4105RG0 Membrane D0S46_RS02005 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase D0S46_RS02010 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein D0S46_RS02025 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) D0S46_RS02040 ENOG41062P1 Diguanylate cyclase phosphodiesterase D0S46_RS02055 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) D0S46_RS02060 ENOG4105VQ7 Rod shape-determining protein MreD D0S46_RS02065 ENOG4108Z03 MAF-like protein D0S46_RS02070 ENOG4105C03 ribonuclease D0S46_RS02075 ENOG4105QD6 exported protein D0S46_RS02080 ENOG4105D1U peptidase U62 modulator of DNA gyrase D0S46_RS02085 ENOG4105CR8 Transcriptional regulator D0S46_RS02100 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) D0S46_RS02105 ENOG4105UNR (Barnase) inhibitor D0S46_RS02110 ENOG4105RID UPF0379 protein yhcN D0S46_RS02115 ENOG4105RID UPF0379 protein yhcN D0S46_RS02120 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) D0S46_RS02125 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) D0S46_RS02140 ENOG4105C8P )-transporter D0S46_RS02145 ENOG4106DSS Tartrate dehydratase subunit alpha D0S46_RS02150 ENOG4107GFK fumarate D0S46_RS02160 ENOG4107QSA Oxaloacetate decarboxylase D0S46_RS02165 ENOG4105D9Q decarboxylase (Beta subunit) D0S46_RS02175 ENOG4105C0H protease D0S46_RS02180 ENOG4105C0H protease D0S46_RS02185 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III D0S46_RS02190 ENOG4105D6Z AFG1 family ATPase D0S46_RS02195 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) D0S46_RS02210 ENOG4107MKT Stringent starvation protein a D0S46_RS02215 ENOG4105KB2 stringent starvation protein b D0S46_RS02220 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) D0S46_RS02225 ENOG4105BZ8 glutamate synthase D0S46_RS02230 ENOG4105CBC glutamate synthase D0S46_RS02240 ENOG4105N5T Radical SAM Protein D0S46_RS02245 ENOG4108I5G Major Facilitator superfamily D0S46_RS02250 ENOG4105CPQ Dehydrogenase D0S46_RS02255 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) D0S46_RS02260 ENOG4105BZU Histidine kinase D0S46_RS02265 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain D0S46_RS02275 ENOG41080Z8 PHOSPHOCARRIER protein D0S46_RS02280 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) D0S46_RS02285 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN D0S46_RS02290 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA D0S46_RS02295 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D0S46_RS02300 ENOG4108IUZ ABC transporter D0S46_RS02305 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA D0S46_RS02310 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) D0S46_RS02315 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase D0S46_RS02320 ENOG4105C2X Arabinose 5-phosphate isomerase D0S46_RS02325 ENOG4105FEU K -dependent Na -Ca exchanger D0S46_RS02335 ENOG4105DHJ ABC, transporter D0S46_RS02340 ENOG4105CY3 ABC transporter, permease D0S46_RS02345 ENOG4107PE3 Mammalian cell entry related domain protein D0S46_RS02350 ENOG4105E3I toluene tolerance D0S46_RS02355 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane D0S46_RS02360 ENOG4105VFK BolA family D0S46_RS02365 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) D0S46_RS02370 ENOG4105HVQ Regulatory factor of maltose metabolism D0S46_RS02375 ENOG4105EAH synthase D0S46_RS02380 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) D0S46_RS02385 ENOG4105K46 50S ribosomal protein l27 D0S46_RS02390 ENOG4105QYV Membrane D0S46_RS02395 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control D0S46_RS02400 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase D0S46_RS02405 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) D0S46_RS02410 ENOG4105HBR Rna-binding protein D0S46_RS02420 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) D0S46_RS02425 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) D0S46_RS02430 ENOG4105EEI dihydropteroate synthase D0S46_RS02435 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) D0S46_RS02440 ENOG4105NTZ Preprotein translocase subunit SecG D0S46_RS02455 ENOG4108UII YfaZ family D0S46_RS02460 ENOG4108PNB DNA-binding transcriptional regulator D0S46_RS02465 ENOG4105CDH Citrulline--aspartate ligase D0S46_RS02475 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) D0S46_RS02480 ENOG4105CHV Transcription elongation factor NusA D0S46_RS02485 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) D0S46_RS02490 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) D0S46_RS02495 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) D0S46_RS02500 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) D0S46_RS02510 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) D0S46_RS02525 ENOG4105C1J atp-dependent rna helicase D0S46_RS02530 ENOG4105CIC tryptophan-specific transport protein D0S46_RS02535 ENOG4105DEN Luciferase family D0S46_RS02555 ENOG4108YYD acetyltransferase D0S46_RS02560 ENOG41082IR Excinuclease ABC C subunit domain protein D0S46_RS02565 ENOG4108ZPB UPF0306 protein D0S46_RS02570 ENOG4107R7Y intracellular protease Pfpi family D0S46_RS02575 ENOG4105K4T epimerase D0S46_RS02580 ENOG4107S21 permease D0S46_RS02585 ENOG4105W4M Transport-associated protein D0S46_RS02590 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) D0S46_RS02595 ENOG41082RQ UPF0102 protein D0S46_RS02600 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) D0S46_RS02605 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) D0S46_RS02610 ENOG4105CTX dehydratase D0S46_RS02615 ENOG4105DJB Major Facilitator Superfamily D0S46_RS02620 ENOG4105CNV Aldolase D0S46_RS02625 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase D0S46_RS02630 ENOG4105BZW Glycerate kinase D0S46_RS02650 ENOG4108CNN domain protein D0S46_RS02655 ENOG4105CWB LysR family transcriptional Regulator D0S46_RS02660 ENOG4105KAF membrAne D0S46_RS02665 ENOG4105CHF Glutathione S-transferase D0S46_RS02670 ENOG4108VBZ doxx family D0S46_RS02675 ENOG4105YJD D0S46_RS02680 ENOG41090KG Inner membrane protein YqjE D0S46_RS02685 ENOG4105NE1 Conserved Protein D0S46_RS02690 ENOG4105WAY exported protein D0S46_RS02695 ENOG4105VD9 Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) D0S46_RS02700 ENOG4106W5V Membrane D0S46_RS02710 ENOG4107YCY Transcriptional regulator D0S46_RS02715 ENOG4105DPW Major facilitator superfamily MFS_1 D0S46_RS02725 ENOG4105CTX dehydratase D0S46_RS02730 ENOG4105P66 Membrane D0S46_RS02735 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) D0S46_RS02740 ENOG4105DU1 integral membrane protein, terc D0S46_RS02745 ENOG4105EE0 oxidoreductase D0S46_RS02750 ENOG4108VKG metal-dependent hydrolase D0S46_RS02770 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase D0S46_RS02775 ENOG4107RYS Autoinducer-2 (AI-2) kinase D0S46_RS02780 ENOG4105DKT Transcriptional regulator D0S46_RS02785 ENOG4105C2J ABC transporter D0S46_RS02790 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane D0S46_RS02795 ENOG4105F5R ABC transporter D0S46_RS02800 ENOG4105D4B ABC, transporter D0S46_RS02805 ENOG41061GT Aldolase D0S46_RS02810 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound D0S46_RS02815 ENOG4105C8Y Acetylornithine aminotransferase D0S46_RS02825 ENOG4105NTW Transcriptional regulator D0S46_RS02830 ENOG4105Q26 Siderophore-interacting protein D0S46_RS02845 ENOG4108UTZ Dihydroxyacetone kinase D0S46_RS02850 ENOG4105CMT Dihydroxyacetone kinase D0S46_RS02880 ENOG4105C0A alcohol dehydrogenase D0S46_RS02895 ENOG4105YCI dehydratase medium subunit D0S46_RS02900 ENOG4108ZFT Dehydratase small subunit D0S46_RS02905 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit D0S46_RS02910 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) D0S46_RS02915 ENOG4105XXV Acid-resistance protein D0S46_RS02920 ENOG4108YK4 Acid-resistance membrane protein D0S46_RS02925 ENOG4108V08 YfdX protein D0S46_RS02930 ENOG4105BZU Histidine kinase D0S46_RS02935 ENOG4108WQH regulatoR D0S46_RS02955 ENOG4108VCA G U mismatch-specific DNA glycosylase D0S46_RS02960 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D0S46_RS02965 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) D0S46_RS02980 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) D0S46_RS02990 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) D0S46_RS02995 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) D0S46_RS03000 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) D0S46_RS03005 ENOG4105EQR Transposase IS116 IS110 IS902 D0S46_RS03015 ENOG4105KI2 Urea amidohydrolase subunit beta D0S46_RS03020 ENOG4108YZ9 Urea amidohydrolase subunit gamma D0S46_RS03025 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) D0S46_RS03035 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) D0S46_RS03040 ENOG4107ZVW dihydroneopterin aldolase D0S46_RS03045 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) D0S46_RS03050 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate D0S46_RS03055 ENOG4106MWK domain protein D0S46_RS03060 ENOG4105I7R Adenylate cyclase D0S46_RS03065 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) D0S46_RS03070 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) D0S46_RS03080 ENOG4105W0Z cytoplasmic protein D0S46_RS03095 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b D0S46_RS03100 ENOG4106032 Glutathionylspermidine synthase D0S46_RS03105 ENOG4105F1G UPF0441 protein D0S46_RS03115 ENOG41087AY ADP-Ribose pyrophosphatase D0S46_RS03120 ENOG4108SX3 cytoplasmic protein D0S46_RS03125 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) D0S46_RS03130 ENOG4105IPS esterase D0S46_RS03135 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D0S46_RS03140 ENOG4105VRH Antibiotic biosynthesis monooxygenase D0S46_RS03145 ENOG4105NF4 modulator of drug activity D0S46_RS03150 ENOG4105DHQ Histidine kinase D0S46_RS03155 ENOG4105XJC Two component transcriptional regulator (Winged helix family D0S46_RS03160 ENOG4105H4F exported protein D0S46_RS03165 ENOG4105F4I Transcriptional regulator D0S46_RS03175 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D0S46_RS03180 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase D0S46_RS03185 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) D0S46_RS03190 ENOG4105CCT upf0313 protein D0S46_RS03200 ENOG4105CV8 reductase D0S46_RS03205 ENOG4108I6A alcohol dehydrogenase D0S46_RS03210 ENOG4105CF7 AraC family transcriptional regulator D0S46_RS03215 ENOG4108K81 inner membrane protein YghB D0S46_RS03220 ENOG4105C28 cystathionine D0S46_RS03230 ENOG4105CWK Biopolymer transport protein, ExbB D0S46_RS03235 ENOG4108ZZF transport protein (ExbD) D0S46_RS03240 ENOG4105CT4 transporter D0S46_RS03245 ENOG4105E4I Glycoside hydrolase family 28 D0S46_RS03250 ENOG4108TEB UPF0114 protein D0S46_RS03260 ENOG410900S Protein of unknown function (DUF2623) D0S46_RS03265 ENOG4105CYM Glutathione S-transferase D0S46_RS03275 ENOG4106032 Glutathionylspermidine synthase D0S46_RS03280 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D0S46_RS03300 ENOG4105CC0 LysR family Transcriptional regulator D0S46_RS03305 ENOG4105C28 cystathionine D0S46_RS03320 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae D0S46_RS03335 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae D0S46_RS03340 ENOG4108VCD Chaperone D0S46_RS03345 ENOG4105CW0 outer membrane usher protein D0S46_RS03370 ENOG4108UQV Membrane D0S46_RS03380 ENOG4105CXN decarboxylase D0S46_RS03385 ENOG4105EAA nucleoside D0S46_RS03390 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division D0S46_RS03395 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) D0S46_RS03400 ENOG4105CEN a g-specific adenine glycosylase D0S46_RS03405 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) D0S46_RS03410 ENOG41090ED Protein with unknown function (DUF469) D0S46_RS03415 ENOG4105K33 Periplasmic Protein D0S46_RS03420 ENOG4108HWW ABC transporter D0S46_RS03425 ENOG4105C2J ABC transporter D0S46_RS03435 ENOG4105CSA Coproporphyrinogen iii oxidase D0S46_RS03440 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) D0S46_RS03445 ENOG4105VZ9 UPF0235 protein D0S46_RS03450 ENOG4108VIA integral membrane protein D0S46_RS03455 ENOG4105DFA alanine racemase domain protein D0S46_RS03460 ENOG4105CZX twitching motility protein D0S46_RS03465 ENOG41086KC Transcriptional regulator D0S46_RS03470 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) D0S46_RS03475 ENOG4108UJU UPF0301 protein D0S46_RS03480 ENOG4105D7Z glutathione synthase D0S46_RS03485 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) D0S46_RS03490 ENOG4105RWS endonuclease I D0S46_RS03495 ENOG4105GPY SprT protein D0S46_RS03500 ENOG4107QNK )-transporter D0S46_RS03505 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP D0S46_RS03525 ENOG4105CYW agmatinase D0S46_RS03530 ENOG41090KI Outer membrane porin D0S46_RS03535 ENOG4108K0D peptidase, M48 D0S46_RS03540 ENOG4105CV1 Transketolase (EC 2.2.1.1) D0S46_RS03545 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase D0S46_RS03555 ENOG4105D2N Aldolase D0S46_RS03560 ENOG4105D64 Mechanosensitive ion channel D0S46_RS03565 ENOG4108ZUB Lysine exporter protein (Lyse ygga) D0S46_RS03570 ENOG4105MPN Membrane D0S46_RS03575 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) D0S46_RS03580 ENOG4105E66 phosphoriboisomerase A D0S46_RS03585 ENOG4108JQ1 Dehydrogenase D0S46_RS03590 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase D0S46_RS03600 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) D0S46_RS03605 ENOG4105E07 UPF0149 protein D0S46_RS03610 ENOG4107RAQ aminopeptidase D0S46_RS03615 ENOG4105D0A hydroxylase D0S46_RS03620 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family D0S46_RS03625 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) D0S46_RS03630 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) D0S46_RS03635 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor D0S46_RS03640 ENOG4105CYX Short-chain dehydrogenase reductase Sdr D0S46_RS03645 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen D0S46_RS03665 ENOG4105CS2 ec 3.2.1.21 D0S46_RS03670 ENOG4108Q3X Transcriptional regulator D0S46_RS03675 ENOG4105N5Z UPF0267 protein D0S46_RS03680 ENOG4108UT2 hemolysin iii D0S46_RS03690 ENOG4105Y75 tpr repeat protein D0S46_RS03695 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB D0S46_RS03700 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) D0S46_RS03705 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) D0S46_RS03710 ENOG4105T95 Thiol disulfide interChange protein D0S46_RS03715 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) D0S46_RS03725 ENOG4105CRK lysyL-tRNA synthetase D0S46_RS03730 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) D0S46_RS03735 ENOG4108UQV Membrane D0S46_RS03740 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase D0S46_RS03745 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) D0S46_RS03750 ENOG4106P55 Transcriptional regulator D0S46_RS03755 ENOG4108K5P (LipO)protein D0S46_RS03765 ENOG4105C0R drug resistance transporter emrb qaca subfamily D0S46_RS03780 ENOG4105CPC Aldo Keto reductase D0S46_RS03795 ENOG4105W7K Transcriptional regulator D0S46_RS03820 ENOG4107R5R arsenical pump membrane protein D0S46_RS03825 ENOG4105K89 arsenate reductase D0S46_RS03830 ENOG4105DUX Transporter D0S46_RS03835 ENOG4105V2F Uncharacterized protein yoac D0S46_RS03840 ENOG4105ETP RND efflux system, outer membrane lipoprotein D0S46_RS03845 ENOG4108MI0 Resistance protein D0S46_RS03850 ENOG4105J12 Multidrug resistance protein mdtN D0S46_RS03860 ENOG4105VR1 Pfam:DUF1271 D0S46_RS03865 ENOG410830R acetyltransferase D0S46_RS03875 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin D0S46_RS03880 ENOG4108T65 Fimbrial D0S46_RS03885 ENOG4108SQA Fimbrial D0S46_RS03890 ENOG4105CW0 outer membrane usher protein D0S46_RS03895 ENOG4108NAE Fimbrial chaperone protein D0S46_RS03900 ENOG4108S54 Fimbrial protein D0S46_RS03905 ENOG4108RQP Major type 1 subunit fimbrin D0S46_RS03910 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off D0S46_RS03915 ENOG4108W9T type 1 fimbriae regulatory protein D0S46_RS03925 ENOG4105D7X high-affinity nickel-transporter D0S46_RS03930 ENOG4108ZT1 Transcriptional regulator D0S46_RS03935 ENOG4108KTG Membrane protein, drug metabolite transporter D0S46_RS03945 ENOG4108T1W Fimbrial subunit type 3 D0S46_RS03985 ENOG4107S5I aldo keto reductase D0S46_RS03990 ENOG4108MHD transport protein D0S46_RS04000 ENOG4105C5Q Transcriptional regulator D0S46_RS04005 ENOG4105CHU acetyl-coa acetyltransferase D0S46_RS04015 ENOG4108QGT oligogalacturonate-specific porin D0S46_RS04020 ENOG4105CAZ oligogalacturonide lyase D0S46_RS04025 ENOG4105CHR reductase D0S46_RS04030 ENOG4107QNK )-transporter D0S46_RS04035 ENOG4106NDP Transcriptional regulator D0S46_RS04040 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) D0S46_RS04045 ENOG4108HKT sucrose-6-phosphate hydrolase D0S46_RS04060 ENOG4108IJ9 (ABC) transporter D0S46_RS04065 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component D0S46_RS04070 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component D0S46_RS04075 ENOG4105YKW D0S46_RS04085 ENOG4105RQF LysR family Transcriptional regulator D0S46_RS04095 ENOG4105DDV Transcriptional regulator (LacI family D0S46_RS04100 ENOG4105CK1 PTS System D0S46_RS04105 ENOG4105CS2 ec 3.2.1.21 D0S46_RS04110 ENOG4107YCY Transcriptional regulator D0S46_RS04120 ENOG41060NJ transcriptional regulator D0S46_RS04135 ENOG4105CEY Amp-dependent synthetase and ligase D0S46_RS04140 ENOG4107S74 Lysophospholipid transporter LplT D0S46_RS04145 ENOG4105CPC Aldo Keto reductase D0S46_RS04150 ENOG4105SUV lipoprotein YgdR D0S46_RS04155 ENOG4105EE5 Membrane protein terC D0S46_RS04160 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) D0S46_RS04170 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) D0S46_RS04175 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase D0S46_RS04180 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) D0S46_RS04185 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) D0S46_RS04190 ENOG4105IPU prepilin peptidase dependent protein A D0S46_RS04195 ENOG4105JCS prepilin peptidase dependent protein D0S46_RS04200 ENOG4105SEN Protein of unknown function (DUF2509) D0S46_RS04205 ENOG4105RVB Prepilin peptidase dependent protein c D0S46_RS04210 ENOG4105DSY exodeoxyribonuclease V, gamma D0S46_RS04215 ENOG4107QXK peptidase D0S46_RS04225 ENOG4107QYX exodeoxyribonuclease v alpha D0S46_RS04235 ENOG4107QZM n-acetylglutamate synthase D0S46_RS04240 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase D0S46_RS04245 ENOG4107QZB decarboxylase D0S46_RS04250 ENOG4105JZC GHMP kinase D0S46_RS04255 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) D0S46_RS04260 ENOG4105KTW ethanolamine utilization protein D0S46_RS04265 ENOG4105M3W utilization protein D0S46_RS04275 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) D0S46_RS04280 ENOG4105C0A alcohol dehydrogenase D0S46_RS04285 ENOG4108EKI Dehydrogenase D0S46_RS04295 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml D0S46_RS04310 ENOG4105KNY Microcompartments protein D0S46_RS04315 ENOG4105KNY Microcompartments protein D0S46_RS04325 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit D0S46_RS04330 ENOG4108ZFT Dehydratase small subunit D0S46_RS04335 ENOG4105YCI dehydratase medium subunit D0S46_RS04340 ENOG4105DMB glycerol dehydratase D0S46_RS04345 ENOG4105EHR propanediol utilization protein pduB D0S46_RS04350 ENOG4105KNY Microcompartments protein D0S46_RS04355 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) D0S46_RS04360 ENOG4107XVH Transcriptional regulator D0S46_RS04365 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) D0S46_RS04370 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) D0S46_RS04375 ENOG41081F0 Precorrin-8x methylmutase D0S46_RS04380 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) D0S46_RS04385 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase D0S46_RS04390 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase D0S46_RS04395 ENOG4105CIA precorrin-4 C(11)-methyltransferase D0S46_RS04400 ENOG4108P62 biosynthesis protein (CbiG) D0S46_RS04405 ENOG4105E4R Precorrin-3B C17-methyltransferase D0S46_RS04410 ENOG4105QUC reductase D0S46_RS04415 ENOG4107PPM cobalt chelatase D0S46_RS04420 ENOG4105DVK Precorrin-2 c20-methyltransferase D0S46_RS04425 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) D0S46_RS04430 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) D0S46_RS04435 ENOG4108V4M Cobalt abc transporter D0S46_RS04445 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) D0S46_RS04450 ENOG4108YZT Adenosylcobinamide kinase D0S46_RS04510 ENOG4108ZG0 Ompa motb domain protein D0S46_RS04545 ENOG4105CA3 membrane-bound lytic murein transglycosylase D0S46_RS04550 ENOG4105CUZ uba thif-type nad fad binding protein D0S46_RS04555 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) D0S46_RS04560 ENOG4105C9B Cysteine desulfurase D0S46_RS04565 ENOG4105M5B (LipO)protein D0S46_RS04570 ENOG4105ETT transcriptional Regulator, LysR family D0S46_RS04575 ENOG4105M08 Membrane D0S46_RS04585 ENOG4107EDW L-fucose operon activator D0S46_RS04590 ENOG4105NWF RbsD or FucU transport D0S46_RS04595 ENOG4105CMG Carbohydrate kinase D0S46_RS04600 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) D0S46_RS04605 ENOG4105EDR glucose galactose transporter D0S46_RS04610 ENOG4107W7X Aldolase D0S46_RS04615 ENOG4105C0A alcohol dehydrogenase D0S46_RS04620 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease D0S46_RS04625 ENOG4108JU7 Transcriptional regulator D0S46_RS04630 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) D0S46_RS04645 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) D0S46_RS04650 ENOG4108UMI ABC transporter, permease D0S46_RS04655 ENOG4105D01 (LipO)protein D0S46_RS04665 ENOG41079KZ Major Facilitator Superfamily D0S46_RS04675 ENOG4105GVF (ABC) transporter D0S46_RS04680 ENOG4105EJQ L-serine dehydratase D0S46_RS04685 ENOG4105C44 Serine transporter D0S46_RS04690 ENOG4105EWT decarboxylase family D0S46_RS04695 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) D0S46_RS04700 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) D0S46_RS04705 ENOG4105WP7 tRNA pseudouridine synthase C D0S46_RS04710 ENOG4105DR9 pseudouridine synthase D0S46_RS04715 ENOG4105QDK Flavodoxin D0S46_RS04720 ENOG4105DJB Major Facilitator Superfamily D0S46_RS04725 ENOG4105EQX glucarate dehydratase D0S46_RS04730 ENOG4105EQX glucarate dehydratase D0S46_RS04735 ENOG4105BZW Glycerate kinase D0S46_RS04745 ENOG4105BZU Histidine kinase D0S46_RS04750 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) D0S46_RS04755 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) D0S46_RS04760 ENOG4105DXN mazG family D0S46_RS04765 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) D0S46_RS04770 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) D0S46_RS04780 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) D0S46_RS04785 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase D0S46_RS04790 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) D0S46_RS04795 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) D0S46_RS04800 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) D0S46_RS04805 ENOG4108MXK alkaline phosphatase isozyme conversion D0S46_RS04810 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) D0S46_RS04815 ENOG4105C11 sulfate adenylyltransferase), subunit 2 D0S46_RS04825 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) D0S46_RS04830 ENOG4105N0Z inner membrane protein ygbE D0S46_RS04835 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) D0S46_RS04840 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) D0S46_RS04845 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) D0S46_RS04850 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) D0S46_RS04860 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) D0S46_RS04865 ENOG4108K5P (LipO)protein D0S46_RS04870 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D0S46_RS04895 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase D0S46_RS04900 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) D0S46_RS04905 ENOG4105KZM cytoplasmic protein D0S46_RS04920 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) D0S46_RS04940 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) D0S46_RS04945 ENOG4105EHG Permease protein D0S46_RS04950 ENOG4107R4I Periplasmic binding protein D0S46_RS04955 ENOG4106QJH hemin transport protein D0S46_RS04975 ENOG4108N2Y auxin Efflux D0S46_RS04985 ENOG4105VXR cytoplasmic protein D0S46_RS04990 ENOG4105CC5 ABC transporter D0S46_RS04995 ENOG4105CC5 ABC transporter D0S46_RS05000 ENOG4105DIK (ABC) transporter D0S46_RS05005 ENOG4105DSE periplasmic solute binding protein D0S46_RS05010 ENOG4105DDV Transcriptional regulator (LacI family D0S46_RS05015 ENOG4105DKQ ROK family D0S46_RS05020 ENOG4105VCP PTS System D0S46_RS05025 ENOG4105CK1 PTS System D0S46_RS05030 ENOG4105VZJ PTS System D0S46_RS05035 ENOG4105CK1 PTS System D0S46_RS05045 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) D0S46_RS05055 ENOG4105CS2 ec 3.2.1.21 D0S46_RS05065 ENOG4105C45 hydrogenase expression formation protein (HypE) D0S46_RS05070 ENOG4105CQS hydrogenase expression formation protein HypD D0S46_RS05075 ENOG41083WG hydrogenase assembly chaperone D0S46_RS05080 ENOG4107RSS Hydrogenase accessory protein HypB D0S46_RS05085 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) D0S46_RS05090 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA D0S46_RS05100 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) D0S46_RS05105 ENOG4107R30 NADH dehydrogenase D0S46_RS05110 ENOG4107TDF Formate hydrogenlyase subunit 4 D0S46_RS05115 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D0S46_RS05120 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit D0S46_RS05125 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit D0S46_RS05130 ENOG4105I6X formate hydrogenlyase maturation D0S46_RS05135 ENOG4108MG9 hydrogenase 3 maturation protease D0S46_RS05145 ENOG4105CS2 ec 3.2.1.21 D0S46_RS05150 ENOG4105C5Y PTS System D0S46_RS05155 ENOG4105DDV Transcriptional regulator (LacI family D0S46_RS05160 ENOG4108RC0 Electron transport protein D0S46_RS05165 ENOG4105C8H hydrogenase maturation protein Hypf D0S46_RS05175 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase D0S46_RS05180 ENOG4105CNW domain protein D0S46_RS05190 ENOG4108JUA Transcriptional regulator D0S46_RS05200 ENOG410804X Transcriptional regulator D0S46_RS05205 ENOG4105J92 DNA-binding transcriptional activator GutM D0S46_RS05210 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase D0S46_RS05215 ENOG4105VI0 Pts system, glucitol sorbitol-specific D0S46_RS05220 ENOG4105DZY Pts system, glucitol sorbitol-specific D0S46_RS05225 ENOG410787A Pts system, glucitol sorbitol-specific D0S46_RS05230 ENOG4105CVE Lytic murein transglycosylase D0S46_RS05245 ENOG4105CC5 ABC transporter D0S46_RS05250 ENOG4105DSE periplasmic solute binding protein D0S46_RS05255 ENOG4107TH8 cina domain protein D0S46_RS05260 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) D0S46_RS05265 ENOG4105Y3E Modulates RecA activity (By similarity) D0S46_RS05270 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) D0S46_RS05275 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) D0S46_RS05305 ENOG4105K3G Periplasmic Protein D0S46_RS05310 ENOG4107VXZ Hydrolase D0S46_RS05315 ENOG4105W39 Membrane D0S46_RS05320 ENOG4105D9M gamma-glutamylcysteine synthetase D0S46_RS05335 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) D0S46_RS05340 ENOG4105C0R drug resistance transporter emrb qaca subfamily D0S46_RS05345 ENOG4105CW7 secretion protein, HlyD family D0S46_RS05350 ENOG4105NTK Transcriptional repressor Mpra D0S46_RS05355 ENOG4105ZED uncharacterized protein ygaH D0S46_RS05360 ENOG4108UMN azlc family D0S46_RS05365 ENOG4105GIJ Glycine betaine D0S46_RS05370 ENOG4108HQS Glycine betaine D0S46_RS05375 ENOG4108IJ7 Glycine betaine D0S46_RS05380 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) D0S46_RS05385 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) D0S46_RS05390 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) D0S46_RS05395 ENOG4105WAZ (Glutaredoxin-like protein) NrdH D0S46_RS05400 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) D0S46_RS05405 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D0S46_RS05410 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) D0S46_RS05415 ENOG4108WMJ Protein of unknown function (DUF2002) D0S46_RS05420 ENOG4108RNS Exports L-alanine (By similarity) D0S46_RS05435 ENOG4108X73 DNA- binding protein D0S46_RS05450 ENOG4108V62 Rhodanese domain protein D0S46_RS05455 ENOG41080HT Transcriptional regulator, arsr family D0S46_RS05465 ENOG4105CC0 LysR family Transcriptional regulator D0S46_RS05470 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family D0S46_RS05475 ENOG4105C26 Dehydrogenase D0S46_RS05480 ENOG4105X0I Fimbrial D0S46_RS05485 ENOG4108VCD Chaperone D0S46_RS05490 ENOG4105CW0 outer membrane usher protein D0S46_RS05505 ENOG4105CW0 outer membrane usher protein D0S46_RS05510 ENOG4106P2F Pfam:Pili_assembly_C D0S46_RS05515 ENOG4106EAR Fimbrial protein D0S46_RS05520 ENOG4108WQH regulatoR D0S46_RS05535 ENOG4105EWI Short-chain dehydrogenase reductase Sdr D0S46_RS05540 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase D0S46_RS05545 ENOG4105MP9 class II Aldolase D0S46_RS05555 ENOG4106TNF Periplasmic binding protein D0S46_RS05570 ENOG4105CYW agmatinase D0S46_RS05575 ENOG4105EVZ LysR family transcriptional regulator D0S46_RS05590 ENOG4105C1P efflux transporter, rnd family, mfp subunit D0S46_RS05595 ENOG4105UEI Transcriptional Regulator AraC Family D0S46_RS05620 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) D0S46_RS05625 ENOG4108Z1B Cyclase dehydrase D0S46_RS05635 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) D0S46_RS05640 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) D0S46_RS05645 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) D0S46_RS05655 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ D0S46_RS05660 ENOG4108JU6 CBS domain protein D0S46_RS05665 ENOG4106KVJ cytochrome C assembly protein D0S46_RS05670 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY D0S46_RS05675 ENOG4105K5M 30s ribosomal protein S16 D0S46_RS05680 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) D0S46_RS05685 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) D0S46_RS05690 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) D0S46_RS05705 ENOG41090EK ompa motb domain protein D0S46_RS05710 ENOG4108KHX Diguanylate cyclase D0S46_RS05715 ENOG4108WS1 D0S46_RS05720 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) D0S46_RS05725 ENOG4105EHE chorismate mutase- prephenate dehydrogenase D0S46_RS05735 ENOG4105CQC Prephenate dehydratase D0S46_RS05745 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA D0S46_RS05750 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane D0S46_RS05755 ENOG4105C34 Pseudouridine synthase D0S46_RS05760 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase D0S46_RS05765 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit D0S46_RS05790 ENOG4105CSH Transporter D0S46_RS05795 ENOG4105T42 (LipO)protein D0S46_RS05800 ENOG4105JIM Phosphatidylserine synthase D0S46_RS05805 ENOG4105CD5 CoA-binding domain protein D0S46_RS05810 ENOG4106IUH DTW domain containing protein D0S46_RS05815 ENOG4105K63 Thioredoxin D0S46_RS05820 ENOG4105EIB trna rrna methyltransferase D0S46_RS05825 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) D0S46_RS05830 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) D0S46_RS05835 ENOG4105C1J atp-dependent rna helicase D0S46_RS05840 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) D0S46_RS05845 ENOG4108IYU L-aspartate oxidase D0S46_RS05855 ENOG41069PW sigma-e factor negative regulatory protein D0S46_RS05860 ENOG4105VQK sigma E regulatory protein, MucB RseB D0S46_RS05865 ENOG4105WMJ Positive regulator of sigma E, RseC MucC D0S46_RS05905 ENOG41076J9 exonuclease VIII D0S46_RS05915 ENOG4105UVW uncharacterized protein yebW D0S46_RS05960 ENOG4105JBR DNA replication protein D0S46_RS06010 ENOG4105RWQ Protein of unknown function (DUF1364) D0S46_RS06015 ENOG4105QBX endodeoxyribonuclease RusA D0S46_RS06020 ENOG4105HGD Antitermination protein D0S46_RS06040 ENOG4105NVB glycoside hydrolase, family 19 D0S46_RS06075 ENOG4108TFU terminase (Small subunit) D0S46_RS06220 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) D0S46_RS06225 ENOG4105C3F Signal peptidase i D0S46_RS06230 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) D0S46_RS06235 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) D0S46_RS06240 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) D0S46_RS06245 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) D0S46_RS06250 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) D0S46_RS06255 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding D0S46_RS06260 ENOG4106G6Q Transcriptional regulator D0S46_RS06265 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB D0S46_RS06270 ENOG4108Z6B deaminase D0S46_RS06275 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) D0S46_RS06280 ENOG4108ETH Formylglycinamide ribotide synthetase D0S46_RS06290 ENOG4107WP9 Histidine kinase D0S46_RS06295 ENOG4108SKK alpha helix protein D0S46_RS06300 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D0S46_RS06305 ENOG4108YZA Nitrogen regulatory protein pii D0S46_RS06310 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) D0S46_RS06320 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) D0S46_RS06325 ENOG4108SB3 DoxX Family D0S46_RS06330 ENOG4108NZE NAGC-like transcriptional regulator D0S46_RS06335 ENOG4107HQ7 repeat protein D0S46_RS06340 ENOG4107QNK )-transporter D0S46_RS06345 ENOG4108ZKT aldose 1-epimerase D0S46_RS06350 ENOG4105D8G Major Facilitator superfamily D0S46_RS06355 ENOG4108MN2 Stationary phase inducible protein CsiE D0S46_RS06360 ENOG41065CD Exported protein D0S46_RS06365 ENOG4105D7X high-affinity nickel-transporter D0S46_RS06375 ENOG4105ECY inositol monophosphatase D0S46_RS06380 ENOG4105CVS RNA methyltransferase TrmH family, group 1 D0S46_RS06385 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family D0S46_RS06390 ENOG4105C3J Cysteine desulfurase D0S46_RS06395 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins D0S46_RS06400 ENOG4108Z4V iron-sulfur cluster assembly D0S46_RS06405 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) D0S46_RS06410 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB D0S46_RS06415 ENOG4108ZIT Ferredoxin, 2FE-2S D0S46_RS06420 ENOG4105WVQ Fe-S assembly protein IscX D0S46_RS06425 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) D0S46_RS06430 ENOG4105YYA enhanced serine sensitivity protein SseB D0S46_RS06440 ENOG4105KHC sulfurtransferase D0S46_RS06445 ENOG4105DN3 alpha-2-macroglobulin domain protein D0S46_RS06450 ENOG4108JQB penicillin-binding protein 1C D0S46_RS06455 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) D0S46_RS06465 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs D0S46_RS06470 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) D0S46_RS06475 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) D0S46_RS06485 ENOG4105N21 Membrane D0S46_RS06490 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) D0S46_RS06495 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) D0S46_RS06630 ENOG4105VPD cellular component movement D0S46_RS06635 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) D0S46_RS06640 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) D0S46_RS06645 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) D0S46_RS06655 ENOG4105C4X radical SAM domain protein D0S46_RS06670 ENOG41062G3 Protein of unknown function (DUF2633) D0S46_RS06675 ENOG4105BZU Histidine kinase D0S46_RS06680 ENOG4105C9X ppx gppa phosphatase D0S46_RS06685 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) D0S46_RS06690 ENOG4108V3E phosphoribosylglycinamide formyltransferase D0S46_RS06695 ENOG4105CXB phosphoribosylaminoimidazole synthetase D0S46_RS06700 ENOG41066F8 ROK family D0S46_RS06705 ENOG4105CS2 ec 3.2.1.21 D0S46_RS06710 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) D0S46_RS06715 ENOG4105C2W permease D0S46_RS06720 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) D0S46_RS06730 ENOG4105K89 arsenate reductase D0S46_RS06735 ENOG4105ERG peptidase m48, ste24p D0S46_RS06740 ENOG4105C02 permease D0S46_RS06745 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen D0S46_RS06750 ENOG4105RH4 Glycine cleavage system transcriptional repressor D0S46_RS06755 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) D0S46_RS06760 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) D0S46_RS06765 ENOG4105C8V SAICAR synthetase D0S46_RS06770 ENOG4105CGZ zinc metallopeptidase D0S46_RS06775 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) D0S46_RS06780 ENOG4106KED esterase YpfH D0S46_RS06785 ENOG4105XYK UPF0370 protein D0S46_RS06790 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) D0S46_RS06795 ENOG4105KUZ arsenate reductase D0S46_RS06805 ENOG4105BZS acriflavin resistance protein D0S46_RS06815 ENOG4105BZ8 glutamate synthase D0S46_RS06820 ENOG4107VIJ nudix hydrolase D0S46_RS06825 ENOG4108PVD exported protein D0S46_RS06830 ENOG4105CV1 Transketolase (EC 2.2.1.1) D0S46_RS06835 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) D0S46_RS06840 ENOG4105C6K Malic enzyme D0S46_RS06845 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place D0S46_RS06850 ENOG4106S4J ethanolamine utilization protein EutP D0S46_RS06855 ENOG4105NDK ethanolamine utilization protein D0S46_RS06860 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase D0S46_RS06865 ENOG4108IJ2 phosphate acetyltransferase D0S46_RS06870 ENOG4105KNY Microcompartments protein D0S46_RS06875 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml D0S46_RS06880 ENOG4108EKI Dehydrogenase D0S46_RS06885 ENOG4107YMV ethanolamine utilization protein D0S46_RS06890 ENOG4105C0A alcohol dehydrogenase D0S46_RS06895 ENOG4105ENY Ethanolamine utilization protein eutH D0S46_RS06900 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase D0S46_RS06905 ENOG4105CPD ethanolamine ammonia-lyase D0S46_RS06915 ENOG4106D67 ethanolamine utilization protein D0S46_RS06920 ENOG4108X49 Ethanolamine utilization protein EutK D0S46_RS06925 ENOG4108K3Z AraC family transcriptional regulator D0S46_RS06930 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) D0S46_RS06935 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase D0S46_RS06940 ENOG4108R6G acetyltransferase D0S46_RS06945 ENOG4105QZU Inner membrane protein YfeZ D0S46_RS06950 ENOG4105E7K (LipO)protein D0S46_RS06955 ENOG4105EZR dyp-type peroxidase family protein D0S46_RS06965 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein D0S46_RS06970 ENOG4108I5D sulfate abc transporter D0S46_RS06975 ENOG4105ECW sulfate abc transporter D0S46_RS06980 ENOG4108IJ6 ABC transporter D0S46_RS06985 ENOG4105C6T cysteine synthase D0S46_RS06990 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein D0S46_RS06995 ENOG4105CSW GntR family transcriptional regulator D0S46_RS07000 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) D0S46_RS07010 ENOG4105C5Y PTS System D0S46_RS07015 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) D0S46_RS07020 ENOG4105KZ7 phosphocarrier protein hpr D0S46_RS07025 ENOG4105C6T cysteine synthase D0S46_RS07030 ENOG4105EXN Sulfate transport protein CysZ D0S46_RS07035 ENOG4108C6U receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) D0S46_RS07040 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) D0S46_RS07045 ENOG4105VRT cytoplasmic protein D0S46_RS07050 ENOG4105DHU Bile acid D0S46_RS07055 ENOG4108M0I Transcriptional regulator D0S46_RS07085 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) D0S46_RS07090 ENOG4105GXM Putative transcription regulator (DUF1323) D0S46_RS07095 ENOG4105HZG regulatoR D0S46_RS07105 ENOG4108KMM Diguanylate cyclase D0S46_RS07110 ENOG4105D9N nucleoside D0S46_RS07115 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) D0S46_RS07120 ENOG4109076 Conserved Protein D0S46_RS07125 ENOG4105CPC Aldo Keto reductase D0S46_RS07130 ENOG4107RA9 decarboxylase D0S46_RS07140 ENOG4105CHC glucokinase (EC 2.7.1.2) D0S46_RS07145 ENOG4105DY9 regulatoR D0S46_RS07150 ENOG4108HRK Histidine kinase D0S46_RS07160 ENOG4105CHM Aminotransferase D0S46_RS07170 ENOG4105DJ2 Major Facilitator Superfamily D0S46_RS07175 ENOG4107Y2X deaminase D0S46_RS07180 ENOG4105DND Transcriptional regulator D0S46_RS07200 ENOG4105S64 Formate nitrite transporter D0S46_RS07205 ENOG410903C (LipO)protein D0S46_RS07210 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation D0S46_RS07220 ENOG4105KZW UPF0381 protein D0S46_RS07225 ENOG4105CHU acetyl-coa acetyltransferase D0S46_RS07230 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase D0S46_RS07235 ENOG4108BY2 phosphohistidine phosphatase D0S46_RS07240 ENOG4108DG9 Smr protein MutS2 D0S46_RS07245 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) D0S46_RS07250 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase D0S46_RS07255 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) D0S46_RS07260 ENOG4105EJ9 Membrane D0S46_RS07265 ENOG4108BPE -transporting atpase D0S46_RS07270 ENOG4105MH2 YfcL protein D0S46_RS07275 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) D0S46_RS07280 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) D0S46_RS07285 ENOG4105F9N Major Facilitator Superfamily D0S46_RS07290 ENOG4106WZ1 flagella biosynthesis regulator D0S46_RS07300 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) D0S46_RS07305 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) D0S46_RS07310 ENOG4105DQR SNARE associated Golgi D0S46_RS07315 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) D0S46_RS07320 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase D0S46_RS07325 ENOG4108S3P Sporulation domain protein D0S46_RS07330 ENOG4105E96 Colicin v production protein D0S46_RS07335 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase D0S46_RS07340 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase D0S46_RS07345 ENOG4105E89 ABC transporter D0S46_RS07350 ENOG4105E89 ABC transporter D0S46_RS07355 ENOG4105DSP amino acid AbC transporter D0S46_RS07360 ENOG4106YG3 ABC transporter D0S46_RS07365 ENOG4108JEH abc transporter atp-binding protein D0S46_RS07370 ENOG4105KNA -acetyltransferase D0S46_RS07375 ENOG4105ECP epimerase D0S46_RS07380 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase D0S46_RS07385 ENOG4105CYM Glutathione S-transferase D0S46_RS07390 ENOG4108SHQ Glutathione S-transferase D0S46_RS07395 ENOG4108RE9 Phosphodiesterase D0S46_RS07400 ENOG4105PTV Nudix Hydrolase D0S46_RS07405 ENOG4105C6K Malic enzyme D0S46_RS07410 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) D0S46_RS07415 ENOG4105PQ6 UPF0208 membrane protein D0S46_RS07425 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 D0S46_RS07430 ENOG4107QWE )-transporter D0S46_RS07435 ENOG4105DK2 UPF0207 protein D0S46_RS07440 ENOG4105CHM Aminotransferase D0S46_RS07445 ENOG4107NQ8 LysR family Transcriptional regulator D0S46_RS07460 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain D0S46_RS07465 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D0S46_RS07470 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D0S46_RS07475 ENOG4105GKE subunit e D0S46_RS07480 ENOG4107QIZ NADH dehydrogenase D0S46_RS07485 ENOG4108IEH NADH dehydrogenase subunit g D0S46_RS07490 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) D0S46_RS07500 ENOG4107UFS subunit j D0S46_RS07505 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D0S46_RS07510 ENOG4105D65 subunit l D0S46_RS07515 ENOG4105C8S subunit m D0S46_RS07520 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D0S46_RS07525 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) D0S46_RS07530 ENOG4107YB6 acetyltransferase, (GNAT) family D0S46_RS07535 ENOG4105E4F Isochorismate synthase D0S46_RS07540 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) D0S46_RS07545 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) D0S46_RS07550 ENOG4108IPT Naphthoate synthase D0S46_RS07555 ENOG4105DNI Converts SHCHC to OSB (By similarity) D0S46_RS07560 ENOG4105CEY Amp-dependent synthetase and ligase D0S46_RS07570 ENOG4105DNE Transposase D0S46_RS07580 ENOG4108UII YfaZ family D0S46_RS07585 ENOG4108EWA cinA-like protein D0S46_RS07590 ENOG4107258 Transcriptional regulator D0S46_RS07595 ENOG4105CXK mandelate racemase muconate lactonizing D0S46_RS07600 ENOG4105CSP Major Facilitator Superfamily D0S46_RS07605 ENOG4105CNV Aldolase D0S46_RS07610 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) D0S46_RS07615 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B D0S46_RS07620 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A D0S46_RS07625 ENOG4105CXY transporter D0S46_RS07640 ENOG4105XPH Ferredoxin D0S46_RS07645 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) D0S46_RS07650 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) D0S46_RS07660 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) D0S46_RS07665 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D0S46_RS07670 ENOG4105BZU Histidine kinase D0S46_RS07675 ENOG41068CG regulatoR D0S46_RS07680 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC D0S46_RS07695 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) D0S46_RS07700 ENOG4105CF1 Alkylated DNA repair protein D0S46_RS07705 ENOG4105IBP Cyclic peptide transporter D0S46_RS07710 ENOG4105CJW magnesium transporter D0S46_RS07715 ENOG4105CHH sulfate transporter D0S46_RS07730 ENOG4105F4G Membrane D0S46_RS07740 ENOG4105E68 Sulfatase D0S46_RS07745 ENOG4105PAN UPF0352 protein D0S46_RS07750 ENOG4106V8H Nucleoid-associated protein D0S46_RS07755 ENOG4105N2W Transcriptional regulator D0S46_RS07760 ENOG4107VIJ nudix hydrolase D0S46_RS07775 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) D0S46_RS07780 ENOG4105CFI type iii restriction protein res subunit D0S46_RS07785 ENOG4105I08 Pseudouridine synthase D0S46_RS07790 ENOG4105C2C drug resistance transporter, Bcr CflA D0S46_RS07795 ENOG4105HG6 D0S46_RS07800 ENOG4108JQ5 ABC transporter D0S46_RS07805 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component D0S46_RS07810 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component D0S46_RS07815 ENOG4105E43 Extracellular solute-binding protein, family 5 D0S46_RS07820 ENOG4105CXC rtn protein D0S46_RS07825 ENOG4107TT5 NLP P60 protein D0S46_RS07830 ENOG41076MN Phosphoesterase, PA-phosphatase related D0S46_RS07835 ENOG4105CKI cobalamin synthesis protein D0S46_RS07840 ENOG4105DEI Mannitol dehydrogenase D0S46_RS07845 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) D0S46_RS07855 ENOG4105KRS Proteinase inhibitor D0S46_RS07860 ENOG4105S8Q sugar efflux transporter D0S46_RS07870 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein D0S46_RS07875 ENOG4105DE4 1-phosphofructokinase D0S46_RS07880 ENOG4105DM4 PTS System D0S46_RS07885 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) D0S46_RS07890 ENOG4105HMI Membrane D0S46_RS07900 ENOG4105DUM transcriptional regulator, lysR family D0S46_RS07905 ENOG4108IQI permease D0S46_RS07915 ENOG4105D05 Receptor D0S46_RS07925 ENOG4105EUJ GTP cyclohydrolase i D0S46_RS07930 ENOG4105DHF Membrane D0S46_RS07935 ENOG41060NJ transcriptional regulator D0S46_RS07945 ENOG4105C2J ABC transporter D0S46_RS07950 ENOG4107SDZ Galactoside transport system permease protein mglC D0S46_RS07955 ENOG4107GZ4 SanA protein D0S46_RS07960 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) D0S46_RS07965 ENOG41067MG lrgb family D0S46_RS07970 ENOG4105VAW lrga family D0S46_RS07975 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) D0S46_RS07980 ENOG4105TW1 Carbohydrate-selective porin OprB D0S46_RS07995 ENOG4105CS2 ec 3.2.1.21 D0S46_RS08010 ENOG4105KHU inner membrane protein YohD D0S46_RS08015 ENOG41069YE inner membrane protein yohC D0S46_RS08020 ENOG41061WM D-Alanyl-D-Alanine D0S46_RS08030 ENOG4105CXG d-lactate dehydrogenase D0S46_RS08035 ENOG4107QK4 glycoside hydrolase, family 3 domain protein D0S46_RS08040 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system D0S46_RS08045 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component D0S46_RS08050 ENOG4108IJ8 ABC transporter D0S46_RS08055 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component D0S46_RS08065 ENOG4108HRK Histidine kinase D0S46_RS08070 ENOG4108NEV two component transcriptional regulator, LytTR family D0S46_RS08075 ENOG4108W15 Protein of unknown function (DUF1456) D0S46_RS08080 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) D0S46_RS08085 ENOG4105D1F ATP-binding protein D0S46_RS08095 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly D0S46_RS08100 ENOG4105EJC lysr family transcriptional regulator D0S46_RS08105 ENOG4105C7N Xanthine uracil vitamin C permease D0S46_RS08110 ENOG4105CPN adenine deaminase D0S46_RS08115 ENOG4105DUM transcriptional regulator, lysR family D0S46_RS08130 ENOG4105DWF phosphomethylpyrimidine kinase D0S46_RS08135 ENOG4105EIE fructose-bisphosphate aldolase D0S46_RS08140 ENOG4105IE8 Alpha-ketoglutarate permease D0S46_RS08165 ENOG4105DEI Mannitol dehydrogenase D0S46_RS08170 ENOG4105CMG Carbohydrate kinase D0S46_RS08175 ENOG4105IE8 Alpha-ketoglutarate permease D0S46_RS08180 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 D0S46_RS08185 ENOG4105CXK mandelate racemase muconate lactonizing D0S46_RS08190 ENOG4105DEF Extracellular solute-binding protein, family 5 D0S46_RS08195 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component D0S46_RS08200 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D0S46_RS08210 ENOG4108JQ7 (ABC) transporter D0S46_RS08220 ENOG4105CFP Peptidase U32 D0S46_RS08225 ENOG4105E3W Two component transcriptional regulator (Winged helix family D0S46_RS08230 ENOG4105EB3 Histidine kinase D0S46_RS08235 ENOG4105C0R drug resistance transporter emrb qaca subfamily D0S46_RS08240 ENOG4105BZS acriflavin resistance protein D0S46_RS08245 ENOG4105BZS acriflavin resistance protein D0S46_RS08250 ENOG4105ENT Efflux transporter rnd family, mfp subunit D0S46_RS08255 ENOG4105CK2 sodium dicarboxylate symporter D0S46_RS08270 ENOG4105BZU Histidine kinase D0S46_RS08275 ENOG4105R8A Heat shock protein D0S46_RS08285 ENOG4105D03 DNA-3-methyladenine glycosylase II D0S46_RS08290 ENOG4105DBI uridine monophosphokinase D0S46_RS08295 ENOG4105DHP deoxycytidine triphosphate deaminase D0S46_RS08300 ENOG4108GAE asmA family D0S46_RS08305 ENOG4105EE5 Membrane protein terC D0S46_RS08310 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase D0S46_RS08315 ENOG4105MH5 phosphoesterase PA-phosphatase related protein D0S46_RS08320 ENOG4108MRJ D0S46_RS08325 ENOG4105DAY polysaccharide export protein D0S46_RS08370 ENOG4107T8Q Glycosyl transferase (Group 1 D0S46_RS08385 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) D0S46_RS08400 ENOG4105C1B dTDP-glucose 4-6-dehydratase D0S46_RS08410 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase D0S46_RS08415 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase D0S46_RS08470 ENOG4105CPK Glycosyl transferase (Group 1 D0S46_RS08480 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase D0S46_RS08485 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) D0S46_RS08495 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) D0S46_RS08500 ENOG4105ECC imidazole-glycerol-phosphate dehydratase D0S46_RS08505 ENOG4105CIH Imidazole acetol-phosphate transaminase D0S46_RS08515 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) D0S46_RS08525 ENOG4107SRH Nad-dependent epimerase dehydratase D0S46_RS08530 ENOG4105EQ1 Transcriptional regulator D0S46_RS08540 ENOG4105CUB amino acid D0S46_RS08545 ENOG4105YVS arsR family transcriptional regulator D0S46_RS08550 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) D0S46_RS08555 ENOG4105CJB Exodeoxyribonuclease I D0S46_RS08560 ENOG4105DZ1 carboxypeptidase D0S46_RS08570 ENOG4105DR8 Membrane D0S46_RS08575 ENOG41090HJ UPF0265 protein D0S46_RS08580 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) D0S46_RS08585 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) D0S46_RS08590 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) D0S46_RS08600 ENOG41090U3 tautomerase D0S46_RS08605 ENOG4105HEI LysR family (Transcriptional regulator D0S46_RS08610 ENOG4108KMH lipoate-protein ligase a D0S46_RS08615 ENOG4105CSH Transporter D0S46_RS08630 ENOG4105BZU Histidine kinase D0S46_RS08640 ENOG4108YS1 cytoplasmic protein D0S46_RS08645 ENOG4105YP6 Domain of unknown function (DUF1869) D0S46_RS08650 ENOG4105ETT transcriptional Regulator, LysR family D0S46_RS08665 ENOG4105BZU Histidine kinase D0S46_RS08770 ENOG4108PCE TRANSFER protein D0S46_RS08800 ENOG4106D0Q Type IV secretion system protein VirB2 D0S46_RS08845 ENOG4107ZSV Receptor D0S46_RS08850 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase D0S46_RS08870 ENOG4105C0W non-ribosomal peptide synthetase D0S46_RS08885 ENOG4105BZ1 (ABC) transporter D0S46_RS08890 ENOG4105EYM Major Facilitator superfamily D0S46_RS08910 ENOG4105UQX Mate efflux family protein D0S46_RS08920 ENOG4105FYV Amp nucleosidase D0S46_RS08940 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family D0S46_RS08945 ENOG4108WUH Transcriptional regulator, TetR family D0S46_RS08950 ENOG4105EEQ Na H antiporter D0S46_RS08965 ENOG4107R11 Transcriptional regulator D0S46_RS08970 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein D0S46_RS08990 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) D0S46_RS09000 ENOG4105FCK Membrane D0S46_RS09010 ENOG4105Y0K Inner membrane protein YedR D0S46_RS09015 ENOG4105EST Metal Dependent Phosphohydrolase D0S46_RS09020 ENOG4105DVF Cytosine-specific methyltransferase D0S46_RS09025 ENOG41090BB DNA mismatch endonuclease (vsr) D0S46_RS09030 ENOG4105FDR Membrane D0S46_RS09035 ENOG4105CKW Inner membrane protein yedI D0S46_RS09045 ENOG4105YX3 cellular response to acidity D0S46_RS09060 ENOG4105JCU Inherit from NOG: (Lipo)protein D0S46_RS09065 ENOG4105E5K Alpha-amylase D0S46_RS09070 ENOG4105EAB amino acid AbC transporter D0S46_RS09075 ENOG4105K6H D-cysteine desulfhydrase D0S46_RS09080 ENOG4105E5Q amino acid AbC transporter D0S46_RS09085 ENOG4105CDA abc transporter atp-binding protein D0S46_RS09090 ENOG4105VJY transcriptional regulator D0S46_RS09095 ENOG4105XVG cytoplasmic protein D0S46_RS09100 ENOG4105WH1 Two component transcriptional regulator luxr family D0S46_RS09135 ENOG4106RHG Yeca family D0S46_RS09140 ENOG4105E0U tyrosine-specific transport protein D0S46_RS09145 ENOG4105VVZ metal-binding protein D0S46_RS09150 ENOG41090A1 ferritin D0S46_RS09165 ENOG4105C0R drug resistance transporter emrb qaca subfamily D0S46_RS09170 ENOG4105N4N Protein of unknown function (DUF2766) D0S46_RS09185 ENOG4108UEC Ferritin-like protein D0S46_RS09195 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator D0S46_RS09205 ENOG4105CNN ABC, transporter D0S46_RS09215 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase D0S46_RS09220 ENOG4108VA4 Universal stress protein D0S46_RS09225 ENOG4105CT4 transporter D0S46_RS09230 ENOG4105F5H Glycosyl Hydrolase Family 88 D0S46_RS09235 ENOG4105C75 arginyL-tRNA synthetase D0S46_RS09240 ENOG4106ZCM YecM protein D0S46_RS09245 ENOG4106N3A copper homeostasis protein cutc D0S46_RS09250 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) D0S46_RS09255 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) D0S46_RS09260 ENOG4105WJG Glutathione D0S46_RS09265 ENOG41081XQ Conserved Protein D0S46_RS09270 ENOG4107R08 Integrase D0S46_RS09390 ENOG4105MPK DNA polymerase III subunit theta D0S46_RS09400 ENOG410757E Protein NinE homolog from lambdoid prophage DLP12 D0S46_RS09435 ENOG4105KUS lysozyme D0S46_RS09440 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 D0S46_RS09595 ENOG4105EKQ RNA-directed DNA polymerase D0S46_RS09610 ENOG4105D3W isochorismatase D0S46_RS09615 ENOG4105C9M aspartyl-trna synthetase D0S46_RS09620 ENOG4108TIT dATP pyrophosphohydrolase D0S46_RS09625 ENOG4105CDY transcriptional regulatory protein D0S46_RS09630 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) D0S46_RS09635 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) D0S46_RS09640 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) D0S46_RS09645 ENOG4105FAV ABC, transporter D0S46_RS09655 ENOG4105NXV High-affinity zinc uptake system protein D0S46_RS09660 ENOG4105DR5 peptidase D0S46_RS09665 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase D0S46_RS09670 ENOG4105CA9 Pyruvate kinase D0S46_RS09675 ENOG4106KNT transcriptional regulator D0S46_RS09690 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase D0S46_RS09695 ENOG4105C01 Dihydroxy-acid dehydratase D0S46_RS09700 ENOG4108UHU Aldolase D0S46_RS09710 ENOG4105X2V dna damage-inducible protein D0S46_RS09715 ENOG4108Q2J Inner membrane protein YebE D0S46_RS09720 ENOG4105CUG Oligopeptidase b D0S46_RS09725 ENOG4105UMD exodeoxyribonuclease X D0S46_RS09730 ENOG4105MPK DNA polymerase III subunit theta D0S46_RS09735 ENOG4105FXM Copper resistance protein D0S46_RS09740 ENOG4108PNC copper resistance D0S46_RS09745 ENOG4105NKT exported protein D0S46_RS09755 ENOG4108MJ5 VirK protein D0S46_RS09760 ENOG4108R1E Serine threonine protein phosphatase 1 D0S46_RS09765 ENOG4105UVW uncharacterized protein yebW D0S46_RS09770 ENOG4105WT8 Protein of unknown function (DUF1480) D0S46_RS09775 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B D0S46_RS09780 ENOG4105DY2 Paraquat-inducible protein b D0S46_RS09785 ENOG4105H2K paraquat-inducible protein a D0S46_RS09790 ENOG4108ZGC gaf domain protein D0S46_RS09795 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) D0S46_RS09800 ENOG4105CN1 protease D0S46_RS09805 ENOG4105D0M Protease HtpX homolog D0S46_RS09820 ENOG4105J4Q Transcriptional regulator D0S46_RS09825 ENOG4105TIK D0S46_RS09835 ENOG4105Q3Y exported protein D0S46_RS09860 ENOG4105CJN penicillin-binding protein D0S46_RS09865 ENOG4105DHI Methyltransferase D0S46_RS09870 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) D0S46_RS09875 ENOG4108NK4 UPF0266 membrane protein D0S46_RS09880 ENOG4105F3R pts system mannose fructose sorbose family iid D0S46_RS09885 ENOG4105ETZ PTS System D0S46_RS09890 ENOG4105DAS pts system D0S46_RS09895 ENOG4105EE5 Membrane protein terC D0S46_RS09900 ENOG4107XTP (EAL) domain protein D0S46_RS09905 ENOG4105EJQ L-serine dehydratase D0S46_RS09910 ENOG4105P8F nudix hydrolase D0S46_RS09920 ENOG4105X5C UPF0181 protein D0S46_RS09925 ENOG4105M4H endoribonuclease L-psp D0S46_RS09930 ENOG4105DVT helicase D0S46_RS09935 ENOG41072GX Peptidase M22 Glycoprotease D0S46_RS09945 ENOG4105CEY Amp-dependent synthetase and ligase D0S46_RS09950 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) D0S46_RS09955 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) D0S46_RS09960 ENOG4107QMS site-determining protein D0S46_RS09965 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) D0S46_RS09970 ENOG4105VNG YcgL domain-containing protein D0S46_RS09975 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase D0S46_RS09980 ENOG4108ZZ3 UPF0260 protein D0S46_RS09990 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) D0S46_RS09995 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) D0S46_RS10000 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) D0S46_RS10005 ENOG4105ED1 spovr family D0S46_RS10010 ENOG4105MWK D-amino acid dehydrogenase, small subunit D0S46_RS10020 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) D0S46_RS10025 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A D0S46_RS10030 ENOG4106JQ5 Transglycosylase SLT domain D0S46_RS10035 ENOG4105E0K tonB-dependent siderophore receptor D0S46_RS10100 ENOG410811B TRANSCRIPTIONal D0S46_RS10105 ENOG4105C7B Threonine dehydratase D0S46_RS10110 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) D0S46_RS10120 ENOG4105C6N Formate acetyltransferase D0S46_RS10130 ENOG4105C32 Amino acid ABC transporter (Permease) D0S46_RS10135 ENOG4105CF8 branched-chain amino acid ABC transporter, permease D0S46_RS10140 ENOG4105C0Z ABC transporter D0S46_RS10145 ENOG4108IV0 ABC, transporter D0S46_RS10150 ENOG4107YNJ LysR family Transcriptional regulator D0S46_RS10170 ENOG4105CSH Transporter D0S46_RS10180 ENOG4105F04 LysR family Transcriptional regulator D0S46_RS10190 ENOG4105D3G Pseudouridine synthase D0S46_RS10195 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme D0S46_RS10225 ENOG4108ZG0 Ompa motb domain protein D0S46_RS10230 ENOG4105CS6 Rhs element vgr protein D0S46_RS10245 ENOG4105E6M Sulphatase-modifying factor protein D0S46_RS10320 ENOG4105C3G gtp-binding protein D0S46_RS10325 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) D0S46_RS10330 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria D0S46_RS10340 ENOG4105CHH sulfate transporter D0S46_RS10345 ENOG4105C5T Phosphoribosyl pyrophosphate synthase D0S46_RS10355 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) D0S46_RS10365 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) D0S46_RS10370 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) D0S46_RS10375 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) D0S46_RS10380 ENOG4108YY7 Invasion gene expression up-regulator SirB D0S46_RS10385 ENOG41063JG Transcriptional regulator D0S46_RS10390 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase D0S46_RS10395 ENOG4105EWV Sodium calcium exchanger membrane region D0S46_RS10400 ENOG4105WS7 Cation transport regulator D0S46_RS10405 ENOG4108NH8 Cation transport protein D0S46_RS10415 ENOG41090EX DsrE family D0S46_RS10425 ENOG4105I5W Transporter D0S46_RS10435 ENOG4105D7T ABC transporter D0S46_RS10440 ENOG4107QZF nitrite reductase NADPH large subunit D0S46_RS10450 ENOG4105ID0 Putative invasin D0S46_RS10455 ENOG4105WH1 Two component transcriptional regulator luxr family D0S46_RS10460 ENOG4105BZU Histidine kinase D0S46_RS10465 ENOG4105DQQ Major facilitator superfamily MFS_1 D0S46_RS10470 ENOG4105CRU nitrate reductase, alpha subunit D0S46_RS10475 ENOG4108IUE nitrate reductase beta subunit D0S46_RS10480 ENOG4105R3A Nitrate reductase D0S46_RS10485 ENOG41076YT nitrate reductase, gamma subunit D0S46_RS10540 ENOG4105CIY formyltetrahydrofolate deformylase D0S46_RS10550 ENOG4105D78 K07001 NTE family protein D0S46_RS10555 ENOG4105I93 response regulator D0S46_RS10560 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase D0S46_RS10570 ENOG4107104 thymidine kinase D0S46_RS10575 ENOG4105C0A alcohol dehydrogenase D0S46_RS10585 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein D0S46_RS10590 ENOG4108J59 Extracellular solute-binding protein, family 5 D0S46_RS10595 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component D0S46_RS10600 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D0S46_RS10605 ENOG4105C3U ABC transporter D0S46_RS10610 ENOG4108JQ7 (ABC) transporter D0S46_RS10615 ENOG4105EYW Ion transport protein D0S46_RS10620 ENOG4108W5H UPF0263 protein D0S46_RS10625 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) D0S46_RS10635 ENOG4108YYC ycei family D0S46_RS10640 ENOG4105K9H YciI-like protein D0S46_RS10645 ENOG410822N TonB family D0S46_RS10655 ENOG4105P10 Uncharacterized protein ydiZ D0S46_RS10660 ENOG4105DE4 1-phosphofructokinase D0S46_RS10665 ENOG4108NE3 Salt-induced outer membrane protein D0S46_RS10680 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) D0S46_RS10685 ENOG41082NX 50s ribosomal protein l35 D0S46_RS10700 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) D0S46_RS10705 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) D0S46_RS10710 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) D0S46_RS10720 ENOG4105MWK D-amino acid dehydrogenase, small subunit D0S46_RS10725 ENOG4105RQF LysR family Transcriptional regulator D0S46_RS10735 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) D0S46_RS10740 ENOG4105D01 (LipO)protein D0S46_RS10745 ENOG4108V06 Glutathione peroxidase D0S46_RS10755 ENOG4108QBX (LipO)protein D0S46_RS10760 ENOG4105CNG UPF0061 protein D0S46_RS10770 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) D0S46_RS10780 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) D0S46_RS10790 ENOG4105IPI Membrane D0S46_RS10795 ENOG4105CQB FAD linked oxidase domain protein D0S46_RS10800 ENOG4105KA0 thioesterase Superfamily protein D0S46_RS10805 ENOG4105Y3U Transglycosylase-associated protein D0S46_RS10825 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) D0S46_RS10835 ENOG4105E0A ABC, transporter D0S46_RS10840 ENOG4105EHG Permease protein D0S46_RS10850 ENOG4106KR7 LysR family Transcriptional regulator D0S46_RS10875 ENOG4105DMF Dehydrogenase D0S46_RS10880 ENOG4105KBX Transcriptional regulator, TetR family D0S46_RS10895 ENOG4108Z4V iron-sulfur cluster assembly D0S46_RS10900 ENOG4105DIW FeS assembly protein SUFB D0S46_RS10905 ENOG4105C3K feS assembly ATPase SufC D0S46_RS10910 ENOG4105JRK feS assembly protein SufD D0S46_RS10915 ENOG4105C9B Cysteine desulfurase D0S46_RS10920 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) D0S46_RS10925 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein D0S46_RS10935 ENOG4105CA9 Pyruvate kinase D0S46_RS10945 ENOG4105RFR Protein of unknown function (DUF2767) D0S46_RS10960 ENOG4105DJB Major Facilitator Superfamily D0S46_RS10965 ENOG4105E2X shikimate dehydrogenase D0S46_RS10970 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein D0S46_RS10975 ENOG4108W0P ABC transporter D0S46_RS10980 ENOG4105EHG Permease protein D0S46_RS10985 ENOG4105S10 periplasmic binding protein D0S46_RS10990 ENOG4108K2P TRANSCRIPTIONal D0S46_RS10995 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase D0S46_RS11005 ENOG4107UB2 Alpha beta hydrolase fold D0S46_RS11010 ENOG4105IKQ hydratase D0S46_RS11020 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) D0S46_RS11025 ENOG4108SC4 )-transporter D0S46_RS11040 ENOG4108T2C cysteine dioxygenase type I D0S46_RS11045 ENOG4105CR8 Transcriptional regulator D0S46_RS11050 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) D0S46_RS11070 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component D0S46_RS11075 ENOG4108IY8 ABC, transporter D0S46_RS11085 ENOG4105E0A ABC, transporter D0S46_RS11090 ENOG4105DQ5 transport system permease protein D0S46_RS11110 ENOG4106PMH Extracellular solute-binding protein family 3 D0S46_RS11115 ENOG4105E5Q amino acid AbC transporter D0S46_RS11120 ENOG4105CDA abc transporter atp-binding protein D0S46_RS11135 ENOG41083G8 Multidrug resistance protein MdtM D0S46_RS11155 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) D0S46_RS11160 ENOG4105DG4 malate L-lactate dehydrogenase D0S46_RS11175 ENOG4107Z33 ABC transporter, permease D0S46_RS11210 ENOG41060M0 Crispr-associated protein, cse4 family D0S46_RS11220 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) D0S46_RS11225 ENOG4105PWE CRISPR-associated protein cas2 D0S46_RS11235 ENOG4105GMB type VI secretion system effector, hcp1 family D0S46_RS11265 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) D0S46_RS11270 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) D0S46_RS11275 ENOG41060IM Heme exporter protein D0S46_RS11285 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) D0S46_RS11290 ENOG4105DA4 cytochrome c-type biogenesis protein D0S46_RS11295 ENOG4107QX9 Thiol disulfide interChange protein D0S46_RS11300 ENOG4105KWW Biogenesis protein D0S46_RS11330 ENOG4105CHR reductase D0S46_RS11335 ENOG4105C7K acetolactate synthase D0S46_RS11350 ENOG4105DTD Dehydrogenase D0S46_RS11355 ENOG4105CY2 Citrate transporter D0S46_RS11360 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) D0S46_RS11365 ENOG4105CHU acetyl-coa acetyltransferase D0S46_RS11370 ENOG4107QNJ CoA-transferase subunit B D0S46_RS11380 ENOG4106NZI LysR family Transcriptional regulator D0S46_RS11400 ENOG4105CQB FAD linked oxidase domain protein D0S46_RS11405 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component D0S46_RS11425 ENOG4105KME endoribonuclease L-psp D0S46_RS11430 ENOG4107TTD cytosine deaminase D0S46_RS11445 ENOG4105EMY transcriptional regulator D0S46_RS11480 ENOG4108BUD transposase D0S46_RS11500 ENOG4108BUD transposase D0S46_RS11510 ENOG4105M5B (LipO)protein D0S46_RS11555 ENOG4105IE8 Alpha-ketoglutarate permease D0S46_RS11560 ENOG4107Z96 xylose isomerase D0S46_RS11570 ENOG4108RVA ribokinase D0S46_RS11600 ENOG4108JQ7 (ABC) transporter D0S46_RS11605 ENOG4105C3U ABC transporter D0S46_RS11630 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase D0S46_RS11635 ENOG4105E98 transcriptional regulator DeoR family D0S46_RS11645 ENOG4107B2H carbonic anhydrase D0S46_RS11665 ENOG4105CY0 Metallo-Beta-Lactamase D0S46_RS11685 ENOG4105E1F short-chain dehydrogenase reductase D0S46_RS11715 ENOG4108URH decarboxylase D0S46_RS11725 ENOG4107QI1 Mate efflux family protein D0S46_RS11730 ENOG4108R6K riboflavin synthase, subunit alpha D0S46_RS11735 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase D0S46_RS11740 ENOG4105CZQ inner membrane transport protein YdhC D0S46_RS11745 ENOG4105F52 Transcriptional regulator D0S46_RS11750 ENOG4105ETE Transcriptional regulator (LacI family D0S46_RS11760 ENOG4105F27 Major Facilitator D0S46_RS11765 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) D0S46_RS11775 ENOG4105K4H Nlp p60 protein D0S46_RS11780 ENOG4105M2J Glutaredoxin D0S46_RS11785 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) D0S46_RS11790 ENOG4108UYE Lactoylglutathione lyase D0S46_RS11795 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase D0S46_RS11800 ENOG4108WUH Transcriptional regulator, TetR family D0S46_RS11805 ENOG4105XZD Fe-S protein D0S46_RS11810 ENOG4107RGM aldo keto reductase D0S46_RS11815 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) D0S46_RS11820 ENOG4105DSW Fusaric acid resistance protein D0S46_RS11825 ENOG4105Y49 secretion protein, HlyD family D0S46_RS11845 ENOG4108XTF Outer Membrane Lipoprotein D0S46_RS11850 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) D0S46_RS11855 ENOG410642K Lysozyme inhibitor D0S46_RS11860 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) D0S46_RS11865 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) D0S46_RS11870 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) D0S46_RS11875 ENOG4108K3A Glutathione S-transferase D0S46_RS11890 ENOG4105CSM endonuclease III D0S46_RS11900 ENOG4108UQQ Electron transport complex D0S46_RS11925 ENOG4105M9B inner membrane protein ydgK D0S46_RS11935 ENOG4105CS2 ec 3.2.1.21 D0S46_RS11945 ENOG4105D9R oxidoreductase D0S46_RS11950 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) D0S46_RS11955 ENOG4105EQ0 Major Facilitator superfamily D0S46_RS11975 ENOG4105CPW cytochrome b561 D0S46_RS11995 ENOG4105DDW LysR family Transcriptional regulator D0S46_RS12000 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha D0S46_RS12005 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta D0S46_RS12010 ENOG4105E32 cytoplasmic protein D0S46_RS12015 ENOG4105EBR Carboxylesterase D0S46_RS12030 ENOG4108Z9I -acetyltransferase D0S46_RS12035 ENOG4107WE3 acetyltransferase YdcK D0S46_RS12040 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein D0S46_RS12045 ENOG41088CC tellurite resistance protein tehB D0S46_RS12050 ENOG4108KKZ (LipO)protein D0S46_RS12055 ENOG4108RNG Permease of the drug metabolite transporter D0S46_RS12060 ENOG4105UEI Transcriptional Regulator AraC Family D0S46_RS12065 ENOG4105DKK Benzoate D0S46_RS12070 ENOG4108JCI Transcriptional regulator D0S46_RS12080 ENOG4105CFP Peptidase U32 D0S46_RS12100 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii D0S46_RS12105 ENOG4105C4M (Ubiquinol oxidase) subunit I D0S46_RS12110 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D0S46_RS12115 ENOG4107TYH extracellular solute-binding protein family 1 D0S46_RS12120 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D0S46_RS12125 ENOG4105D81 ABC transporter, permease D0S46_RS12130 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component D0S46_RS12135 ENOG4105C26 Dehydrogenase D0S46_RS12155 ENOG410654E Membrane D0S46_RS12160 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 D0S46_RS12170 ENOG4105DEF Extracellular solute-binding protein, family 5 D0S46_RS12175 ENOG4105R71 cytoplasmic protein D0S46_RS12180 ENOG4108T9Y Inner membrane protein ydcZ D0S46_RS12185 ENOG4108Z7F N-acetyltransferase D0S46_RS12195 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein D0S46_RS12200 ENOG4105DU0 nucleoside hydrolase D0S46_RS12210 ENOG41065TG regulatoR D0S46_RS12215 ENOG4105CI2 imidazolone-5-propionate hydrolase D0S46_RS12220 ENOG4105CHB tonB-dependent Receptor D0S46_RS12225 ENOG4108NS2 receptor D0S46_RS12235 ENOG4105C85 amino acid D0S46_RS12240 ENOG4105EQ2 LysR family Transcriptional regulator D0S46_RS12250 ENOG4105DEN Luciferase family D0S46_RS12265 ENOG4105EAB amino acid AbC transporter D0S46_RS12280 ENOG4105CDA abc transporter atp-binding protein D0S46_RS12290 ENOG4108N27 Glutathione S-transferase D0S46_RS12295 ENOG4105KZK Tautomerase pptA D0S46_RS12320 ENOG4105CT4 transporter D0S46_RS12335 ENOG4108MEJ flavin reductase domain protein D0S46_RS12340 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D0S46_RS12345 ENOG4105C4Y ABC transporter D0S46_RS12350 ENOG4107RCV ABC transporter, permease D0S46_RS12355 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase D0S46_RS12360 ENOG4105D0D Nitrate reductase 2, gamma subunit D0S46_RS12365 ENOG4108NZN Respiratory nitrate reductase 2 delta chain D0S46_RS12370 ENOG4108IUE nitrate reductase beta subunit D0S46_RS12375 ENOG4105CRU nitrate reductase, alpha subunit D0S46_RS12380 ENOG4107QND Nitrite extrusion protein D0S46_RS12395 ENOG4107HP6 Transcriptional regulator D0S46_RS12400 ENOG4105DTQ mandelate racemase muconate lactonizing D0S46_RS12405 ENOG4105NN7 muconolactone delta-isomerase D0S46_RS12410 ENOG410626B catechol 1,2-dioxygenase D0S46_RS12420 ENOG4108UKV benzoate 1,2-dioxygenase D0S46_RS12450 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein D0S46_RS12455 ENOG4108MG3 formate dehydrogenase D0S46_RS12470 ENOG4105CSR polyphosphate kinase 2 D0S46_RS12480 ENOG4105F27 Major Facilitator D0S46_RS12495 ENOG4108JQ6 ABC transporter D0S46_RS12500 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D0S46_RS12515 ENOG4105DQ4 alcohol dehydrogenase D0S46_RS12530 ENOG4105C5H ABC transporter D0S46_RS12540 ENOG4107R1I NAD-dependent malic enzyme D0S46_RS12555 ENOG4105EQ2 LysR family Transcriptional regulator D0S46_RS12560 ENOG4105N0E Protein of unknown function (DUF2543) D0S46_RS12565 ENOG4105CYX Short-chain dehydrogenase reductase Sdr D0S46_RS12590 ENOG4108N8X transition metal ion binding D0S46_RS12600 ENOG4105CG3 alpha amylase, catalytic region D0S46_RS12620 ENOG4108YDI single-species biofilm formation on inanimate substrate D0S46_RS12625 ENOG4108Z9K Osmotically inducible protein D0S46_RS12650 ENOG4105FFC UPF0187 protein D0S46_RS12655 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit D0S46_RS12660 ENOG4105C5Q Transcriptional regulator D0S46_RS12665 ENOG4105CK1 PTS System D0S46_RS12690 ENOG4105VZJ PTS System D0S46_RS12695 ENOG4105VCP PTS System D0S46_RS12700 ENOG4108KUU Inner membrane metabolite transport protein ydjE D0S46_RS12710 ENOG4105KT7 mgtC SapB transporter D0S46_RS12715 ENOG4105D6Z AFG1 family ATPase D0S46_RS12720 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) D0S46_RS12735 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) D0S46_RS12745 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E D0S46_RS12755 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) D0S46_RS12760 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) D0S46_RS12770 ENOG4108IGT Dipeptidase D0S46_RS12775 ENOG4108J2P Alpha beta hydrolase fold D0S46_RS12785 ENOG4105E0F Histidine kinase D0S46_RS12800 ENOG4105DY8 decarboxylase D0S46_RS12805 ENOG4108JPW Aminotransferase D0S46_RS12810 ENOG4107Z6I Thiamine biosynthesis protein D0S46_RS12815 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component D0S46_RS12820 ENOG4108YI8 ABC transporter D0S46_RS12825 ENOG4105ETU transcriptional activator (TenA D0S46_RS12840 ENOG4105CIB oxidoreductase Domain protein D0S46_RS12850 ENOG4105ETE Transcriptional regulator (LacI family D0S46_RS12855 ENOG4105BZU Histidine kinase D0S46_RS12860 ENOG4107QUY Guanine deaminase D0S46_RS12865 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease D0S46_RS12900 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) D0S46_RS12910 ENOG41089BK Glutamine amido-transferase D0S46_RS12915 ENOG4105R1U AraC Family Transcriptional Regulator D0S46_RS12930 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) D0S46_RS12950 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) D0S46_RS12975 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) D0S46_RS12995 ENOG4105E5Q amino acid AbC transporter D0S46_RS13005 ENOG4105C5R Aminotransferase D0S46_RS13020 ENOG4105CBN LysR family transcriptional regulator D0S46_RS13030 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase D0S46_RS13035 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain D0S46_RS13040 ENOG4105CSH Transporter D0S46_RS13070 ENOG4105FCD Major Facilitator D0S46_RS13080 ENOG4105ETE Transcriptional regulator (LacI family D0S46_RS13085 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia D0S46_RS13095 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC D0S46_RS13100 ENOG4105UP7 3-epimerase D0S46_RS13110 ENOG4108YRF PTS System D0S46_RS13115 ENOG4105DM4 PTS System D0S46_RS13120 ENOG410829K Lysine exporter protein (Lyse ygga) D0S46_RS13130 ENOG4105CBN LysR family transcriptional regulator D0S46_RS13135 ENOG4105HEI LysR family (Transcriptional regulator D0S46_RS13150 ENOG4107PP3 Acetylornithine deacetylase D0S46_RS13165 ENOG4105CNN ABC, transporter D0S46_RS13170 ENOG4105C2J ABC transporter D0S46_RS13175 ENOG4105ETE Transcriptional regulator (LacI family D0S46_RS13205 ENOG4109066 lysm domain bon superfamily protein D0S46_RS13210 ENOG4105CXY transporter D0S46_RS13220 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC D0S46_RS13230 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta D0S46_RS13235 ENOG4105RHY Pfam:UPF0157 D0S46_RS13240 ENOG4105EQ2 LysR family Transcriptional regulator D0S46_RS13245 ENOG4105CPC Aldo Keto reductase D0S46_RS13250 ENOG4107SET aldo keto reductase D0S46_RS13255 ENOG4108TY5 Exhibits lactonase activity. Acts in cells with perturbed membrane integrity and is possibly related to the membrane homeostasis D0S46_RS13260 ENOG4105CPC Aldo Keto reductase D0S46_RS13290 ENOG4105KME endoribonuclease L-psp D0S46_RS13295 ENOG4105DZ2 Transcriptional regulator D0S46_RS13300 ENOG4105C28 cystathionine D0S46_RS13305 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D0S46_RS13310 ENOG4105C44 Serine transporter D0S46_RS13315 ENOG4105CR8 Transcriptional regulator D0S46_RS13325 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii D0S46_RS13330 ENOG4105C4M (Ubiquinol oxidase) subunit I D0S46_RS13340 ENOG4105K63 Thioredoxin D0S46_RS13370 ENOG4105ETT transcriptional Regulator, LysR family D0S46_RS13380 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) D0S46_RS13385 ENOG4105CHR reductase D0S46_RS13390 ENOG4105CHU acetyl-coa acetyltransferase D0S46_RS13410 ENOG4105BZW Glycerate kinase D0S46_RS13415 ENOG4107VHA regulatoR D0S46_RS13435 ENOG4107YCY Transcriptional regulator D0S46_RS13440 ENOG4105CI1 PTS System D0S46_RS13445 ENOG4105F8D glycoside hydrolase family 4 D0S46_RS13450 ENOG4105C54 Major Facilitator superfamily D0S46_RS13455 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein D0S46_RS13475 ENOG4105NIV Esterase D0S46_RS13480 ENOG4105BZU Histidine kinase D0S46_RS13495 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) D0S46_RS13510 ENOG4108VCD Chaperone D0S46_RS13515 ENOG4105CW0 outer membrane usher protein D0S46_RS13530 ENOG4105F32 YngK protein D0S46_RS13535 ENOG4105CAF HipA N-terminal domain protein D0S46_RS13540 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein D0S46_RS13545 ENOG4105VT2 5-hydroxyisourate hydrolase D0S46_RS13550 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) D0S46_RS13555 ENOG4105C2W permease D0S46_RS13560 ENOG41061H0 Monooxygenase D0S46_RS13565 ENOG4108KSA LysR family transcriptional regulator D0S46_RS13585 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions D0S46_RS13600 ENOG4105VYA Uncharacterized conserved protein (DUF2132) D0S46_RS13610 ENOG4105D01 (LipO)protein D0S46_RS13620 ENOG4108UMI ABC transporter, permease D0S46_RS13625 ENOG4105EA8 2-Nitropropane dioxygenase D0S46_RS13630 ENOG4105EGI Transcriptional regulator D0S46_RS13635 ENOG4105CBP Major Facilitator D0S46_RS13650 ENOG4105F9N Major Facilitator Superfamily D0S46_RS13700 ENOG4107QZW Altronate oxidoreductase D0S46_RS13710 ENOG4105BZU Histidine kinase D0S46_RS13715 ENOG4105M0C cytoplasmic protein D0S46_RS13720 ENOG4105CSV Glutaminase D0S46_RS13725 ENOG4105C26 Dehydrogenase D0S46_RS13730 ENOG4105EGI Transcriptional regulator D0S46_RS13740 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) D0S46_RS13745 ENOG4105MVE transcriptional regulator D0S46_RS13750 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) D0S46_RS13755 ENOG4107S2N Type III effector Hrp-dependent D0S46_RS13760 ENOG4105C0A alcohol dehydrogenase D0S46_RS13765 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) D0S46_RS13770 ENOG4108JQ1 Dehydrogenase D0S46_RS13780 ENOG4105JAB phenazine biosynthesis protein, phzf family D0S46_RS13785 ENOG4105F27 Major Facilitator D0S46_RS13790 ENOG41082NP Multiple antibiotic resistance D0S46_RS13795 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes D0S46_RS13800 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF D0S46_RS13805 ENOG4106DNR multiple antibiotic resistance protein D0S46_RS13810 ENOG4108594 Permease of the drug metabolite transporter D0S46_RS13815 ENOG4105E5W Transporter D0S46_RS13825 ENOG4108IV0 ABC, transporter D0S46_RS13830 ENOG4105C0Z ABC transporter D0S46_RS13835 ENOG4105CNN ABC, transporter D0S46_RS13845 ENOG41083Z3 extracellular ligand-binding receptor D0S46_RS13860 ENOG4105ECQ AraC Family Transcriptional Regulator D0S46_RS13875 ENOG4105ETE Transcriptional regulator (LacI family D0S46_RS13885 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) D0S46_RS13890 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) D0S46_RS13905 ENOG4105MVE transcriptional regulator D0S46_RS13915 ENOG4105G63 Type III effector Hrp-dependent D0S46_RS13920 ENOG4105FB2 class II Aldolase D0S46_RS13925 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) D0S46_RS13930 ENOG4105C6Z Gluconate D0S46_RS13950 ENOG4105BZU Histidine kinase D0S46_RS13955 ENOG4108WTK competence damage-inducible protein D0S46_RS13960 ENOG4108ZNX Heat shock protein D0S46_RS13975 ENOG4108WQH regulatoR D0S46_RS13980 ENOG4108RAV Conserved protein D0S46_RS13985 ENOG4105R1U AraC Family Transcriptional Regulator D0S46_RS13995 ENOG4105DGW oligopeptidase A D0S46_RS14000 ENOG4105EMU Dehydrogenase D0S46_RS14005 ENOG4107XBN GntR Family Transcriptional Regulator D0S46_RS14010 ENOG4108U51 Universal stress protein D0S46_RS14015 ENOG4105DEI Mannitol dehydrogenase D0S46_RS14020 ENOG4108I5G Major Facilitator superfamily D0S46_RS14030 ENOG4105M5Q UPF0482 protein D0S46_RS14035 ENOG4108MK9 spermidine N(1)-acetyltransferase D0S46_RS14045 ENOG4105KBG Protein of unknown function (DUF1161) D0S46_RS14050 ENOG4107QY8 reductase D0S46_RS14055 ENOG4105QAX Iron-sulfur D0S46_RS14060 ENOG4107KGK dmso reductase anchor subunit D0S46_RS14065 ENOG4108NEM leader-binding protein dmsD D0S46_RS14070 ENOG4105CMQ Chloride channel D0S46_RS14075 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) D0S46_RS14080 ENOG4105DAG ROK family D0S46_RS14085 ENOG4106NZI LysR family Transcriptional regulator D0S46_RS14090 ENOG4105D94 Major Facilitator Superfamily D0S46_RS14095 ENOG4105CTD carboxy-peptidase D0S46_RS14105 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap D0S46_RS14115 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) D0S46_RS14120 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) D0S46_RS14125 ENOG4105DSF transport protein D0S46_RS14155 ENOG4107TT2 Auxin Efflux Carrier D0S46_RS14160 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase D0S46_RS14165 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase D0S46_RS14170 ENOG4108K70 Transcriptional regulator D0S46_RS14175 ENOG4105DWT malate dehydrogenase (quinone) D0S46_RS14180 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate D0S46_RS14190 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism D0S46_RS14195 ENOG4108MRH transcriptional regulatory protein D0S46_RS14220 ENOG4107GFK fumarate D0S46_RS14240 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase D0S46_RS14245 ENOG4105F2Z 3-oxoadipate enol-lactonase D0S46_RS14250 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase D0S46_RS14255 ENOG4105CHU acetyl-coa acetyltransferase D0S46_RS14260 ENOG4107QNJ CoA-transferase subunit B D0S46_RS14270 ENOG4107HP6 Transcriptional regulator D0S46_RS14275 ENOG4108DG9 Smr protein MutS2 D0S46_RS14280 ENOG4106KR7 LysR family Transcriptional regulator D0S46_RS14290 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B D0S46_RS14295 ENOG4105CFC Transporter D0S46_RS14305 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) D0S46_RS14310 ENOG4105DS0 Transcriptional regulator, Crp Fnr family D0S46_RS14315 ENOG4105Q9Y Universal stress protein D0S46_RS14320 ENOG410671Z uncharacterized protein ydiH D0S46_RS14325 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) D0S46_RS14330 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) D0S46_RS14340 ENOG4105C5D exported protein D0S46_RS14350 ENOG4105D5Q Arginine ornithine antiporter D0S46_RS14355 ENOG410642E Short chain dehydrogenase D0S46_RS14360 ENOG4105RA2 Membrane D0S46_RS14365 ENOG4107EXC regulatoR D0S46_RS14375 ENOG4105JJR Histidine kinase D0S46_RS14385 ENOG4105C9Q fumarate hydratase class II D0S46_RS14390 ENOG4107GFK fumarate D0S46_RS14395 ENOG4105EIP mannose-6-phosphate isomerase D0S46_RS14400 ENOG4106J39 exported protein D0S46_RS14405 ENOG4107P2S Transcriptional regulator D0S46_RS14410 ENOG4105CI1 PTS System D0S46_RS14415 ENOG4105C87 Aminotransferase class I and II D0S46_RS14425 ENOG41061EV selenium-binding protein YdfZ D0S46_RS14440 ENOG41066VF YeeE YedE family protein D0S46_RS14450 ENOG41064WM Uncharacterized protein YcgX D0S46_RS14455 ENOG4105VPI YqaE family transport protein D0S46_RS14460 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase D0S46_RS14465 ENOG4105C26 Dehydrogenase D0S46_RS14470 ENOG4107DB1 DUF218 domain D0S46_RS14475 ENOG4105CSH Transporter D0S46_RS14485 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) D0S46_RS14490 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) D0S46_RS14495 ENOG4105C26 Dehydrogenase D0S46_RS14500 ENOG4105F4X arginine D0S46_RS14505 ENOG4105C8Y Acetylornithine aminotransferase D0S46_RS14510 ENOG4105D82 Glutamate dehydrogenase D0S46_RS14515 ENOG4108FN7 Aldo keto reductase D0S46_RS14520 ENOG410642W LysR family Transcriptional regulator D0S46_RS14540 ENOG4105ENJ RND efflux system, outer membrane lipoprotein D0S46_RS14550 ENOG4105CQ7 ATP-dependent helicase D0S46_RS14555 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) D0S46_RS14565 ENOG4108Z0R Transferase D0S46_RS14570 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein D0S46_RS14575 ENOG4105DZS Phenylacetate-CoA ligase D0S46_RS14580 ENOG4105CHU acetyl-coa acetyltransferase D0S46_RS14585 ENOG4108ZJI phenylacetic acid degradation protein D0S46_RS14590 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase D0S46_RS14595 ENOG4108UKI Enoyl-CoA hydratase D0S46_RS14600 ENOG4105E39 Enoyl-CoA hydratase D0S46_RS14605 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) D0S46_RS14610 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit D0S46_RS14615 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit D0S46_RS14620 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit D0S46_RS14625 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit D0S46_RS14630 ENOG4105DXM phenylacetic acid degradation protein D0S46_RS14640 ENOG4105F11 amine oxidase D0S46_RS14655 ENOG4105C26 Dehydrogenase D0S46_RS14660 ENOG4108WFR AraC Family Transcriptional Regulator D0S46_RS14665 ENOG4105WXT Conserved Protein D0S46_RS14670 ENOG410689M (LipO)protein D0S46_RS14675 ENOG4107H52 Dicarboxylate transport D0S46_RS14680 ENOG4108KF1 Membrane D0S46_RS14685 ENOG4105C5I Dehydrogenase D0S46_RS14690 ENOG41090X5 Heat shock protein hslJ D0S46_RS14695 ENOG4105IKK cytoplasmic protein D0S46_RS14705 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) D0S46_RS14710 ENOG4105FCK Membrane D0S46_RS14720 ENOG4108RW8 Universal stress protein F D0S46_RS14730 ENOG4105C1J atp-dependent rna helicase D0S46_RS14745 ENOG4107RX3 Mg2 transporter protein cora family protein D0S46_RS14755 ENOG4105E98 transcriptional regulator DeoR family D0S46_RS14760 ENOG4105D9R oxidoreductase D0S46_RS14775 ENOG4105C85 amino acid D0S46_RS14780 ENOG4105F7P transcriptional regulator AsnC family D0S46_RS14790 ENOG4105CGF Aromatic amino acid aminotransferase D0S46_RS14795 ENOG4108UMI ABC transporter, permease D0S46_RS14805 ENOG4105D01 (LipO)protein D0S46_RS14840 ENOG4105HEI LysR family (Transcriptional regulator D0S46_RS14865 ENOG4108XFH Transcriptional regulator D0S46_RS14870 ENOG4105F6U Short-chain dehydrogenase reductase Sdr D0S46_RS14935 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit D0S46_RS14945 ENOG4108ZG0 Ompa motb domain protein D0S46_RS14970 ENOG4108Z0Z intracellular protease Pfpi family D0S46_RS14985 ENOG4105CBN LysR family transcriptional regulator D0S46_RS15020 ENOG4105EQR Transposase IS116 IS110 IS902 D0S46_RS15055 ENOG4105BZU Histidine kinase D0S46_RS15070 ENOG4107RTG Major Facilitator superfamily D0S46_RS15075 ENOG4105ENX hydrolase D0S46_RS15080 ENOG4105EQ2 LysR family Transcriptional regulator D0S46_RS15095 ENOG4107QSI ABC, transporter D0S46_RS15100 ENOG4105KXI murein peptide amidase A D0S46_RS15105 ENOG4107S8C mandelate racemase muconate lactonizing D0S46_RS15110 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) D0S46_RS15115 ENOG4108KK1 membrane protein AbrB duplication D0S46_RS15120 ENOG4108JU8 Transcriptional regulator D0S46_RS15125 ENOG4105F8D glycoside hydrolase family 4 D0S46_RS15130 ENOG4105W8I Transcriptional regulator D0S46_RS15135 ENOG4106K28 UPF0283 membrane protein D0S46_RS15140 ENOG4105CM6 amino acid regulated cytosolic protein D0S46_RS15145 ENOG4105NNG Peripheral inner membrane phage-shock protein D0S46_RS15150 ENOG4105FM1 phage shock protein C D0S46_RS15155 ENOG4105YYT phage shock protein B D0S46_RS15160 ENOG41087YS Phage shock protein A D0S46_RS15165 ENOG4105E51 psp operon transcriptional activator D0S46_RS15175 ENOG4105CH2 amidohydrolase D0S46_RS15180 ENOG41063ZK Transcriptional Regulator AraC Family D0S46_RS15195 ENOG4108J59 Extracellular solute-binding protein, family 5 D0S46_RS15200 ENOG4108EKA peptide transport system, permease D0S46_RS15205 ENOG4108EU3 peptide transport system, permease D0S46_RS15210 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein D0S46_RS15215 ENOG4108JQ2 peptide transport system atp-binding protein D0S46_RS15220 ENOG4105ETS cytosine purines uracil thiamine allantoin D0S46_RS15230 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH D0S46_RS15235 ENOG4105Q4T oxidoreductase D0S46_RS15240 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) D0S46_RS15250 ENOG4105N2W Transcriptional regulator D0S46_RS15255 ENOG41061RM osmotically inducible lipoprotein D0S46_RS15260 ENOG4108ZJT translation initiation factor, Sui1 D0S46_RS15270 ENOG4105CFV Tetratricopeptide repeat protein D0S46_RS15275 ENOG4105Q4A inner membrane protein yciS D0S46_RS15280 ENOG4105EYK Phosphatidylglycerophosphatase B D0S46_RS15285 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) D0S46_RS15290 ENOG4107QM5 aconitate hydratase D0S46_RS15305 ENOG4107R11 Transcriptional regulator D0S46_RS15310 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) D0S46_RS15315 ENOG4105RKX Protein of unknown function (DUF2498) D0S46_RS15320 ENOG4105ERU peptidase D0S46_RS15330 ENOG4105UBK short-chain dehydrogenase reductase D0S46_RS15335 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase D0S46_RS15365 ENOG4105ETT transcriptional Regulator, LysR family D0S46_RS15375 ENOG4107RTD sua5 ycio yrdc ywlc family protein D0S46_RS15380 ENOG4105DB7 PHP domain protein D0S46_RS15385 ENOG4105CRQ synthase (Component I) D0S46_RS15390 ENOG4108EFP Anthranilate synthase component II D0S46_RS15395 ENOG4105DK0 Indole-3-glycerol phosphate synthase D0S46_RS15400 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) D0S46_RS15405 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) D0S46_RS15450 ENOG4108IU3 tonb-dependent siderophore receptor D0S46_RS15455 ENOG4107E2E PKHD-type hydroxylase D0S46_RS15460 ENOG4105EIF outer membrane protein W D0S46_RS15465 ENOG4105PI0 Ferredoxin D0S46_RS15470 ENOG4108S3I UPF0259 membrane protein D0S46_RS15475 ENOG4107835 probably involved in intracellular septation (By similarity) D0S46_RS15480 ENOG4107RNH Outer membrane receptor FepA D0S46_RS15485 ENOG4105NAU thioesterase Superfamily protein D0S46_RS15490 ENOG4107PN8 YfeABCD locus regulator D0S46_RS15495 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 D0S46_RS15500 ENOG4105CHR reductase D0S46_RS15505 ENOG4107K5X Membrane-bound metal-dependent hydrolase D0S46_RS15510 ENOG4108ETY sodium dicarboxylate symporter D0S46_RS15515 ENOG4105R8J Activates the cell division inhibited by chromosomal DNA over-replication (By similarity) D0S46_RS15520 ENOG4105CH6 catalase D0S46_RS15525 ENOG410901P UPF0249 protein D0S46_RS15530 ENOG4105F8D glycoside hydrolase family 4 D0S46_RS15535 ENOG4105EZV Transcriptional regulator D0S46_RS15540 ENOG4105VCP PTS System D0S46_RS15545 ENOG4105CK1 PTS System D0S46_RS15550 ENOG4105VZJ PTS System D0S46_RS15555 ENOG4105KKI DNA-binding transcriptional activator OsmE D0S46_RS15565 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) D0S46_RS15570 ENOG4108SPG Periplasmic Protein D0S46_RS15580 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) D0S46_RS15585 ENOG4105C26 Dehydrogenase D0S46_RS15590 ENOG4105F4X arginine D0S46_RS15600 ENOG4105CGK Exodeoxyribonuclease III D0S46_RS15605 ENOG4108RSN SNARE associated Golgi D0S46_RS15610 ENOG4108N5C SNARE associated Golgi protein-related protein D0S46_RS15615 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) D0S46_RS15620 ENOG4105VNH ABC transporter solute-binding protein D0S46_RS15625 ENOG4105CXZ ABC transporter, permease D0S46_RS15630 ENOG4108VGW abc transporter atp-binding protein D0S46_RS15635 ENOG4107RM6 sulfurtransferase D0S46_RS15640 ENOG4108T9J Cdp-alcohol phosphatidyltransferase D0S46_RS15645 ENOG4105M6F mutator MutT protein D0S46_RS15650 ENOG4105D82 Glutamate dehydrogenase D0S46_RS15665 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) D0S46_RS15670 ENOG4105SBG acid phosphatase D0S46_RS15685 ENOG41069NU Nitroreductase D0S46_RS15690 ENOG4105D07 Signal peptide peptidase, SppA D0S46_RS15695 ENOG4105HDK L-asparaginase D0S46_RS15700 ENOG4108RWI nicotinamidase D0S46_RS15710 ENOG4105N1F Hnh endonuclease D0S46_RS15715 ENOG4105VUT cytoplasmic protein D0S46_RS15720 ENOG4105E0X reductase D0S46_RS15725 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase D0S46_RS15730 ENOG4105DSB aldose 1-epimerase D0S46_RS15735 ENOG4105CV8 reductase D0S46_RS15740 ENOG4105GNX MltA-interacting MipA family protein D0S46_RS15745 ENOG4105CYN Serine protein kinase D0S46_RS15750 ENOG4106AKX UPF0229 protein D0S46_RS15760 ENOG4108V06 Glutathione peroxidase D0S46_RS15775 ENOG4105F27 Major Facilitator D0S46_RS15780 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr D0S46_RS15785 ENOG4105CBN LysR family transcriptional regulator D0S46_RS15790 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) D0S46_RS15795 ENOG4105KT5 UmuD protein D0S46_RS15800 ENOG4105EKQ RNA-directed DNA polymerase D0S46_RS15810 ENOG4105Y50 Virulence Protein D0S46_RS15815 ENOG4108XNZ glycosyl transferase D0S46_RS15820 ENOG4108KXH Ybak prolyl-tRNA synthetase associated D0S46_RS15825 ENOG4108VMM UPF0756 membrane protein D0S46_RS15830 ENOG4105R1U AraC Family Transcriptional Regulator D0S46_RS15835 ENOG4105DJ2 Major Facilitator Superfamily D0S46_RS15840 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) D0S46_RS15845 ENOG4105EWC Purine nucleoside phosphorylase D0S46_RS15850 ENOG4105K78 MarR family Transcriptional regulator D0S46_RS15855 ENOG4105UCG Domain of unknown function (DUF333) D0S46_RS15860 ENOG4105ZTC transcriptional activator, Ogr delta D0S46_RS15990 ENOG4105ED4 portal protein D0S46_RS16010 ENOG4105DFE Dna adenine methylase D0S46_RS16055 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) D0S46_RS16060 ENOG410620I Diguanylate cyclase D0S46_RS16065 ENOG4106G4W D0S46_RS16080 ENOG4105S5I Membrane D0S46_RS16085 ENOG4108NIW Leucine export protein LeuE D0S46_RS16090 ENOG4105D1S lipid A biosynthesis D0S46_RS16105 ENOG4105DHT Metal Dependent Phosphohydrolase D0S46_RS16110 ENOG4106TD9 Diguanylate cyclase D0S46_RS16115 ENOG4107RSM transcriptional regulator D0S46_RS16120 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) D0S46_RS16145 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii D0S46_RS16150 ENOG4105C4M (Ubiquinol oxidase) subunit I D0S46_RS16155 ENOG4105WEF catalase D0S46_RS16160 ENOG4108N8X transition metal ion binding D0S46_RS16165 ENOG4108Z9Z response to DNA damage stimulus D0S46_RS16175 ENOG4105E2A Dehydrogenase D0S46_RS16180 ENOG4105XDF Protein of unknown function (DUF1272) D0S46_RS16200 ENOG4108ZHR arsR family transcriptional regulator D0S46_RS16205 ENOG4108HMX isocitrate dehydrogenase (NADP) D0S46_RS16220 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) D0S46_RS16225 ENOG41075W9 High frequency lysogenization protein HflD homolog D0S46_RS16230 ENOG4107QTF adenylosuccinate lyase D0S46_RS16250 ENOG4105IFJ Histidine kinase D0S46_RS16255 ENOG4105EZE Cupin 4 family protein D0S46_RS16275 ENOG4105D38 putrescine abc transporter D0S46_RS16280 ENOG4108HM4 ABC transporter D0S46_RS16290 ENOG4105CEY Amp-dependent synthetase and ligase D0S46_RS16295 ENOG4105CV1 Transketolase (EC 2.2.1.1) D0S46_RS16300 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) D0S46_RS16305 ENOG4108YZG isomerase D0S46_RS16310 ENOG4105VI0 Pts system, glucitol sorbitol-specific D0S46_RS16315 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) D0S46_RS16320 ENOG4105G63 Type III effector Hrp-dependent D0S46_RS16335 ENOG4105DKT Transcriptional regulator D0S46_RS16345 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) D0S46_RS16350 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) D0S46_RS16355 ENOG4105D60 lipoprotein releasing system transmembrane protein D0S46_RS16360 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) D0S46_RS16365 ENOG4105D60 lipoprotein releasing system transmembrane protein D0S46_RS16375 ENOG4108JA2 transcriptioN-repair coupling factor D0S46_RS16380 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein D0S46_RS16385 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction D0S46_RS16390 ENOG4108IND Tetr family transcriptional regulator D0S46_RS16400 ENOG4107MBR 17 kDa surface antigen D0S46_RS16405 ENOG4105CEP NADH dehydrogenase D0S46_RS16410 ENOG4105D0Y UPF0227 protein D0S46_RS16425 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) D0S46_RS16430 ENOG41090DQ Lipoprotein D0S46_RS16435 ENOG4105K59 histidine triad (HIT) protein D0S46_RS16440 ENOG4105CI1 PTS System D0S46_RS16445 ENOG4105F8V Hydrolase, tatD family D0S46_RS16450 ENOG4107QRG dna polymerase iii D0S46_RS16455 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) D0S46_RS16460 ENOG4105HHA aminodeoxychorismate lyase D0S46_RS16465 ENOG4105YAZ 4-amino-4-deoxychorismate lyase D0S46_RS16470 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) D0S46_RS16475 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) D0S46_RS16480 ENOG4105CHR reductase D0S46_RS16485 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase D0S46_RS16490 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) D0S46_RS16495 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) D0S46_RS16500 ENOG4105VGS 50s ribosomal protein l32 D0S46_RS16505 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein D0S46_RS16510 ENOG4108UHJ MAF-like protein D0S46_RS16515 ENOG4105EI2 Pseudouridine synthase D0S46_RS16530 ENOG4105CR8 Transcriptional regulator D0S46_RS16535 ENOG4105EQ0 Major Facilitator superfamily D0S46_RS16540 ENOG4105CJR Integral membrane protein (MviN D0S46_RS16545 ENOG4105EP9 oxidoreductase D0S46_RS16550 ENOG4108YXG UPF0502 protein D0S46_RS16555 ENOG4105D9U N-acetyltransferase D0S46_RS16560 ENOG4105EV4 Multidrug resistance protein mdtH D0S46_RS16565 ENOG4105F3T (LipO)protein D0S46_RS16570 ENOG4105EKE dihydroorotase D0S46_RS16575 ENOG4105MEA DNA damage-inducible protein i D0S46_RS16585 ENOG4105PVA Biofilm formation regulatory protein BssS D0S46_RS16595 ENOG4106974 biofilm formation D0S46_RS16605 ENOG4105D1S lipid A biosynthesis D0S46_RS16620 ENOG4108W47 Acidic protein msyB D0S46_RS16625 ENOG4105NAC (LipO)protein D0S46_RS16630 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) D0S46_RS16645 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) D0S46_RS16660 ENOG4108UQ5 membrane protein YcdZ D0S46_RS16665 ENOG4107XHZ cytoplasmic chaperone TorD family protein D0S46_RS16675 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase D0S46_RS16690 ENOG4105HEI LysR family (Transcriptional regulator D0S46_RS16695 ENOG4105EUB pirin domain protein D0S46_RS16700 ENOG4105CHJ isochorismatase hydrolase D0S46_RS16710 ENOG4108Z33 Thiol disulfide Interchange Protein D0S46_RS16715 ENOG4105D5M phosphate starvation-inducible protein D0S46_RS16720 ENOG4105DBE peroxidase D0S46_RS16725 ENOG410650H (LipO)protein D0S46_RS16735 ENOG4105D9N nucleoside D0S46_RS16745 ENOG4105CK7 Sodium proline symporter D0S46_RS16755 ENOG4105C26 Dehydrogenase D0S46_RS16765 ENOG4108R86 Transcriptional regulator D0S46_RS16770 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) D0S46_RS16775 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) D0S46_RS16780 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) D0S46_RS16785 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) D0S46_RS16790 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) D0S46_RS16795 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) D0S46_RS16800 ENOG4105C2W permease D0S46_RS16810 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 D0S46_RS16820 ENOG4105XH3 D0S46_RS16825 ENOG4105D6F Phosphatase D0S46_RS16835 ENOG4105CHR reductase D0S46_RS16850 ENOG4105CUB amino acid D0S46_RS16860 ENOG4105CFQ glutamine synthetase D0S46_RS16865 ENOG4108Z86 Glutamine amidotransferase D0S46_RS16870 ENOG4107VRI Transcriptional regulator D0S46_RS16875 ENOG4105C26 Dehydrogenase D0S46_RS16880 ENOG4105CJP fad dependent oxidoreductase D0S46_RS16885 ENOG4105EJC lysr family transcriptional regulator D0S46_RS16890 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) D0S46_RS16900 ENOG4105C94 Transporter D0S46_RS16905 ENOG4105DVW rieske (2Fe-2S) D0S46_RS16910 ENOG4105C26 Dehydrogenase D0S46_RS16915 ENOG4105E3J oxidoreductase D0S46_RS16920 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) D0S46_RS16925 ENOG4105DM4 PTS System D0S46_RS16930 ENOG4108YRF PTS System D0S46_RS16940 ENOG4108AHH pyruvate formate lyase II activase D0S46_RS16945 ENOG4108XCZ PTS System D0S46_RS16955 ENOG4106R3P AraC family transcriptional regulator D0S46_RS16960 ENOG4105BZU Histidine kinase D0S46_RS16980 ENOG4105BZU Histidine kinase D0S46_RS17000 ENOG4107QSI ABC, transporter D0S46_RS17005 ENOG4108MN8 Membrane D0S46_RS17015 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 D0S46_RS17020 ENOG4108UQN AraC family transcriptional regulator D0S46_RS17025 ENOG4108V1U phospholipid-binding protein D0S46_RS17030 ENOG4105DR4 Methyltransferase D0S46_RS17035 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) D0S46_RS17055 ENOG4108JJA ABC, transporter D0S46_RS17075 ENOG4105K4P CoA-binding domain protein D0S46_RS17085 ENOG41088T4 Helicase IV D0S46_RS17090 ENOG410901E Membrane D0S46_RS17095 ENOG4105EM2 membrane D0S46_RS17100 ENOG4108RZ1 DNA transformation protein D0S46_RS17110 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) D0S46_RS17115 ENOG4105UYK outer membrane protein a D0S46_RS17120 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) D0S46_RS17125 ENOG4105DAN ATP-dependent protease D0S46_RS17130 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) D0S46_RS17135 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) D0S46_RS17145 ENOG4108Q2G (LipO)protein D0S46_RS17150 ENOG4105DY2 Paraquat-inducible protein b D0S46_RS17155 ENOG4105F1S paraquat-inducible protein a D0S46_RS17160 ENOG4105C5H ABC transporter D0S46_RS17165 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) D0S46_RS17170 ENOG4105QVC MOSC domain-containing protein D0S46_RS17175 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) D0S46_RS17185 ENOG4108UZX fmn reductase D0S46_RS17190 ENOG4105GVF (ABC) transporter D0S46_RS17195 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) D0S46_RS17200 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component D0S46_RS17210 ENOG4105CD8 aminopeptidase N D0S46_RS17220 ENOG4107RH7 Nicotinate phosphoribosyltransferase D0S46_RS17225 ENOG4105CH2 amidohydrolase D0S46_RS17230 ENOG4105CE7 Amidase, hydantoinase carbamoylase family D0S46_RS17235 ENOG4105C44 Serine transporter D0S46_RS17240 ENOG4107RCH Diaminopropionate ammonia-lyase D0S46_RS17250 ENOG4105C5S asparaginyl-tRNA synthetase D0S46_RS17255 ENOG4105ZIT Porin Gram-negative type D0S46_RS17260 ENOG4105CGF Aromatic amino acid aminotransferase D0S46_RS17265 ENOG4105C5X domain protein D0S46_RS17270 ENOG4105EAQ (twin-arginine translocation) pathway signal D0S46_RS17280 ENOG4105DIT ErfK YbiS YcfS YnhG family protein D0S46_RS17285 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) D0S46_RS17290 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) D0S46_RS17295 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) D0S46_RS17300 ENOG4106371 Methyltransferase D0S46_RS17305 ENOG4107S90 membrAne D0S46_RS17310 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups D0S46_RS17315 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) D0S46_RS17320 ENOG4105W49 UPF0434 protein D0S46_RS17325 ENOG4105T0Z Conserved Protein D0S46_RS17330 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) D0S46_RS17335 ENOG4105BZ1 (ABC) transporter D0S46_RS17340 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 D0S46_RS17345 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) D0S46_RS17350 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) D0S46_RS17355 ENOG4105CAT Cytidine monophosphate kinase D0S46_RS17360 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase D0S46_RS17365 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) D0S46_RS17370 ENOG4107VMU Membrane D0S46_RS17375 ENOG4105DDY UPF0142 protein ycaO D0S46_RS17380 ENOG4105TMB Formate nitrite transporter D0S46_RS17385 ENOG4105C6N Formate acetyltransferase D0S46_RS17390 ENOG4105F1A Pyruvate formate-lyase D0S46_RS17395 ENOG4108ISG Major Facilitator D0S46_RS17405 ENOG4107KGK dmso reductase anchor subunit D0S46_RS17410 ENOG4105QAX Iron-sulfur D0S46_RS17415 ENOG4107QY8 reductase D0S46_RS17420 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) D0S46_RS17425 ENOG4105D1H recombination factor protein RarA D0S46_RS17430 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) D0S46_RS17435 ENOG4105CNU cell division protein FtsK D0S46_RS17440 ENOG4105EW9 transcriptional regulator AsnC family D0S46_RS17445 ENOG4105C3M thioredoxin reductase D0S46_RS17450 ENOG4108JJ9 ABC, transporter D0S46_RS17455 ENOG4108JJ8 (ABC) transporter D0S46_RS17460 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) D0S46_RS17465 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) D0S46_RS17470 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit D0S46_RS17475 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) D0S46_RS17480 ENOG4105VEQ Cold shock protein D0S46_RS17495 ENOG4105DJY efflux transporter, rnd family, mfp subunit D0S46_RS17500 ENOG4105CPB ATP-dependent endonuclease of the OLD family D0S46_RS17505 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) D0S46_RS17510 ENOG4105DWU Membrane D0S46_RS17520 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) D0S46_RS17535 ENOG4105C7K acetolactate synthase D0S46_RS17540 ENOG4105C5W Aldolase D0S46_RS17545 ENOG4105CGD Nad-dependent epimerase dehydratase D0S46_RS17550 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase D0S46_RS17555 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase D0S46_RS17570 ENOG41064MM (LipO)protein D0S46_RS17575 ENOG4105E5Z arginine transporter ATP-binding subunit D0S46_RS17580 ENOG4106PMH Extracellular solute-binding protein family 3 D0S46_RS17585 ENOG4105GBT ABC transporter D0S46_RS17590 ENOG4105DMR ABC, transporter D0S46_RS17595 ENOG4106TNF Periplasmic binding protein D0S46_RS17600 ENOG4105BZU Histidine kinase D0S46_RS17605 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D0S46_RS17610 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) D0S46_RS17615 ENOG4105RBQ inner membrane protein ybjO D0S46_RS17620 ENOG4105D38 putrescine abc transporter D0S46_RS17625 ENOG4105F38 ABC transporter, permease D0S46_RS17630 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D0S46_RS17635 ENOG4107RUE extracellular solute-binding protein family 1 D0S46_RS17640 ENOG4108RMJ sensory transduction regulator D0S46_RS17650 ENOG4108DBC nitroreductase D0S46_RS17655 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress D0S46_RS17660 ENOG41090BQ Glutaredoxin D0S46_RS17665 ENOG4105GWF inner membrane protein YbjM D0S46_RS17670 ENOG4105D0C transport protein D0S46_RS17675 ENOG4108RFG Tetr family transcriptional regulator D0S46_RS17680 ENOG4106UW1 Major Facilitator superfamily D0S46_RS17685 ENOG4108HCJ Hydrolase D0S46_RS17690 ENOG4107QF7 multi-drug D0S46_RS17700 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase D0S46_RS17705 ENOG4107FB0 transcriptional regulator DeoR family D0S46_RS17710 ENOG4105DZ1 carboxypeptidase D0S46_RS17715 ENOG4108TGY Glutathione S-transferase D0S46_RS17720 ENOG4105D8V Glucose sorbosone dehydrogenase D0S46_RS17725 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway D0S46_RS17730 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) D0S46_RS17735 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) D0S46_RS17745 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D0S46_RS17750 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component D0S46_RS17755 ENOG4105DEF Extracellular solute-binding protein, family 5 D0S46_RS17760 ENOG4108JQ6 ABC transporter D0S46_RS17765 ENOG4105D44 asparaginase D0S46_RS17770 ENOG4105CVM Molybdenum cofactor synthesis domain protein D0S46_RS17775 ENOG4105D06 uba thif-type nad fad binding protein D0S46_RS17780 ENOG4105F1A Pyruvate formate-lyase D0S46_RS17790 ENOG4108HCJ Hydrolase D0S46_RS17795 ENOG41072TH Protein of unknown function (DUF1479) D0S46_RS17800 ENOG4105ETE Transcriptional regulator (LacI family D0S46_RS17805 ENOG4105DPW Major facilitator superfamily MFS_1 D0S46_RS17820 ENOG4105C5H ABC transporter D0S46_RS17825 ENOG4105M2Z protein tyrosine serine phosphatase D0S46_RS17830 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein D0S46_RS17835 ENOG4108TZY GntR Family Transcriptional Regulator D0S46_RS17840 ENOG4105CS2 ec 3.2.1.21 D0S46_RS17845 ENOG4105F4P )-transporter D0S46_RS17850 ENOG4105KST dependent repressor D0S46_RS17860 ENOG4108I6E Sulfatase D0S46_RS17865 ENOG4108T1M outer membrane protein x D0S46_RS17875 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction D0S46_RS17880 ENOG4107R0W ABC transporter D0S46_RS17885 ENOG4105E5Q amino acid AbC transporter D0S46_RS17890 ENOG4105CDA abc transporter atp-binding protein D0S46_RS17895 ENOG4105D8X mechanosensitive ion channel D0S46_RS17900 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) D0S46_RS17905 ENOG4105EW6 flavin reductase domain protein, FMN-binding D0S46_RS17915 ENOG4105KSC Transcriptional regulator, TraR DksA family D0S46_RS17920 ENOG4105VR4 UPF0379 protein ybiJ D0S46_RS17925 ENOG4108MTB glycosyl transferase family D0S46_RS17930 ENOG4105DVT helicase D0S46_RS17935 ENOG4105C1J atp-dependent rna helicase D0S46_RS17955 ENOG4105DJB Major Facilitator Superfamily D0S46_RS17960 ENOG4108PZW LysR family Transcriptional regulator D0S46_RS17965 ENOG4107MVR Transcriptional regulator D0S46_RS17970 ENOG4105D0S secretion protein (HlyD D0S46_RS17975 ENOG4105CJ1 ABC, transporter D0S46_RS17980 ENOG4107QWP ABC-2 type transporter D0S46_RS17985 ENOG4107QWP ABC-2 type transporter D0S46_RS17995 ENOG4105I9U inner membrane protein ybhQ D0S46_RS18000 ENOG4105X23 Endonuclease Exonuclease phosphatase D0S46_RS18005 ENOG4105DZQ phospholipase D Transphosphatidylase D0S46_RS18010 ENOG4107UXM Membrane D0S46_RS18030 ENOG4105HFZ Membrane D0S46_RS18035 ENOG4108ZAF Molybdopterin D0S46_RS18040 ENOG4105M00 molybdopterin converting factor, subunit 1 D0S46_RS18045 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) D0S46_RS18050 ENOG4108RIR Molybdenum cofactor biosynthesis protein D0S46_RS18055 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) D0S46_RS18065 ENOG4105CHW UPF0052 protein D0S46_RS18070 ENOG4105DIJ Phosphoethanolamine transferase D0S46_RS18075 ENOG4105XJC Two component transcriptional regulator (Winged helix family D0S46_RS18080 ENOG4105ECM Sensor protein basS pmrB D0S46_RS18090 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) D0S46_RS18105 ENOG4108IV0 ABC, transporter D0S46_RS18115 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) D0S46_RS18120 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) D0S46_RS18125 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) D0S46_RS18135 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) D0S46_RS18140 ENOG4108V1U phospholipid-binding protein D0S46_RS18145 ENOG4105C85 amino acid D0S46_RS18150 ENOG4105C84 Histidine ammonia-lyase D0S46_RS18165 ENOG41088SP formiminoglutamate hydrolase D0S46_RS18170 ENOG4105CI2 imidazolone-5-propionate hydrolase D0S46_RS18175 ENOG4105NBR Pectinesterase D0S46_RS18185 ENOG4108U51 Universal stress protein D0S46_RS18190 ENOG4105ENT Efflux transporter rnd family, mfp subunit D0S46_RS18220 ENOG4108XDN Transcriptional regulator D0S46_RS18225 ENOG4105BZU Histidine kinase D0S46_RS18230 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component D0S46_RS18245 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) D0S46_RS18250 ENOG4108K4B hydrolase D0S46_RS18260 ENOG4105E0C molybdate abc transporter D0S46_RS18265 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein D0S46_RS18275 ENOG4105F4R Transcriptional regulator mode D0S46_RS18285 ENOG4105CMR udp-glucose 4-epimerase D0S46_RS18290 ENOG4105F0Z galactose-1-phosphate uridylyltransferase D0S46_RS18295 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) D0S46_RS18300 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) D0S46_RS18305 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) D0S46_RS18310 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) D0S46_RS18315 ENOG4105JND homeobox protein D0S46_RS18320 ENOG4105PGM cation diffusion facilitator family transporter D0S46_RS18325 ENOG4106Z1T Nicotinamide Mononucleotide Transporter D0S46_RS18330 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) D0S46_RS18375 ENOG4105UFD tol-pal system protein YbgF D0S46_RS18380 ENOG4105KCK Peptidoglycan-associated lipoprotein D0S46_RS18390 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA D0S46_RS18400 ENOG4105E02 MotA TolQ exbB proton channel D0S46_RS18405 ENOG4107YD3 Thioesterase D0S46_RS18410 ENOG4105KJB cyd operon protein YbgE D0S46_RS18420 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii D0S46_RS18425 ENOG4105C4M (Ubiquinol oxidase) subunit I D0S46_RS18435 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha D0S46_RS18440 ENOG4105CMV Succinyl-CoA synthetase subunit beta D0S46_RS18445 ENOG4105C7S Dehydrogenase D0S46_RS18450 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 D0S46_RS18455 ENOG4105E33 succinate dehydrogenase D0S46_RS18460 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) D0S46_RS18465 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein D0S46_RS18470 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit D0S46_RS18485 ENOG4105BZN citrate synthase D0S46_RS18490 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) D0S46_RS18510 ENOG4105E7W lamb ycsf family protein D0S46_RS18515 ENOG4107R7A Allophanate hydrolase subunit 2 D0S46_RS18520 ENOG4105P4J Allophanate hydrolase, subunit 1 D0S46_RS18525 ENOG4107QNR UPF0135 protein D0S46_RS18530 ENOG4105DUX Transporter D0S46_RS18535 ENOG4105CVP deoxyribo-dipyrimidine photolyase D0S46_RS18540 ENOG4105XIQ Protein of unknown function (DUF2517) D0S46_RS18550 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) D0S46_RS18555 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) D0S46_RS18560 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) D0S46_RS18565 ENOG4105C08 Histidine kinase D0S46_RS18570 ENOG4105EEX Two component transcriptional regulator (Winged helix family D0S46_RS18580 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 D0S46_RS18585 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) D0S46_RS18590 ENOG4105EV9 Alpha Beta Hydrolase D0S46_RS18595 ENOG4105NNH LexA regulated protein D0S46_RS18600 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) D0S46_RS18605 ENOG41090R7 Ferric uptake D0S46_RS18610 ENOG4105CSH Transporter D0S46_RS18615 ENOG4105GX6 (LipO)protein D0S46_RS18620 ENOG4105J5J Outer membrane porin D0S46_RS18630 ENOG4105CX6 glutaminyL-tRNA synthetase D0S46_RS18635 ENOG4105CI1 PTS System D0S46_RS18645 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) D0S46_RS18650 ENOG4105CE4 GlcNAc 6-P deacetylase D0S46_RS18655 ENOG4105E2R ROK family D0S46_RS18660 ENOG4105D4U had-superfamily hydrolase, subfamily iia D0S46_RS18665 ENOG4105CAQ asparagine synthetase D0S46_RS18710 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family D0S46_RS18715 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) D0S46_RS18720 ENOG4105C9A Phoh family D0S46_RS18725 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) D0S46_RS18730 ENOG4108JU5 Magnesium and cobalt efflux protein D0S46_RS18735 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) D0S46_RS18740 ENOG4107RP9 extracellular solute-binding protein, family 3 D0S46_RS18745 ENOG4105EAD ABC transporter D0S46_RS18750 ENOG4105DRP amino acid AbC transporter D0S46_RS18755 ENOG4105CDA abc transporter atp-binding protein D0S46_RS18770 ENOG4107PAI alpha helical protein D0S46_RS18775 ENOG4105C8T Leucyl-tRNA synthetase D0S46_RS18785 ENOG4105DJF DNA polymerase III, delta' subunit D0S46_RS18790 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) D0S46_RS18795 ENOG4108TGR phosphatase D0S46_RS18805 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) D0S46_RS18810 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) D0S46_RS18815 ENOG4105CJN penicillin-binding protein D0S46_RS18820 ENOG4105CNI cell division protein FtsW D0S46_RS18825 ENOG4105K6T rare lipoprotein A D0S46_RS18830 ENOG4105DZ1 carboxypeptidase D0S46_RS18835 ENOG4108Z43 UPF0250 protein D0S46_RS18840 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) D0S46_RS18845 ENOG41064T2 transcriptional regulator, lysR family D0S46_RS18850 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) D0S46_RS18855 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) D0S46_RS18875 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) D0S46_RS18880 ENOG4105CEE C4-dicarboxylate transporter D0S46_RS18885 ENOG4105KTS ribonuclease D0S46_RS18890 ENOG4105NXH GreA GreB family elongation factor D0S46_RS18895 ENOG4108U51 Universal stress protein D0S46_RS18900 ENOG4108JU3 Alkyl hydroperoxide reductase D0S46_RS18905 ENOG4105D3R alkyl hydroperoxide reductase D0S46_RS18910 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase D0S46_RS18915 ENOG4105DQS Transcriptional regulator D0S46_RS18920 ENOG4105BZV Phosphoadenosine phosphosulfate reductase D0S46_RS18925 ENOG4105GTN ParB Domain Protein Nuclease D0S46_RS18930 ENOG4105CHM Aminotransferase D0S46_RS18935 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) D0S46_RS18940 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) D0S46_RS18955 ENOG4105C2J ABC transporter D0S46_RS18965 ENOG4105CNN ABC, transporter D0S46_RS18975 ENOG4108M3J Dehydrogenase D0S46_RS18985 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) D0S46_RS18990 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin D0S46_RS19000 ENOG4105DZC cytosine deaminase D0S46_RS19010 ENOG4105ECY inositol monophosphatase D0S46_RS19015 ENOG4105CXY transporter D0S46_RS19020 ENOG4105D6F Phosphatase D0S46_RS19025 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) D0S46_RS19030 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) D0S46_RS19045 ENOG4105CNN ABC, transporter D0S46_RS19050 ENOG4105C2J ABC transporter D0S46_RS19055 ENOG4107SCQ Iron-containing alcohol dehydrogenase D0S46_RS19060 ENOG4105CHR reductase D0S46_RS19075 ENOG4105VCD cytoplasmic protein D0S46_RS19080 ENOG4105D22 carbon starvation protein D0S46_RS19085 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) D0S46_RS19090 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase D0S46_RS19095 ENOG4105WQI isochorismatase D0S46_RS19100 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase D0S46_RS19105 ENOG4105E4F Isochorismate synthase D0S46_RS19110 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein D0S46_RS19115 ENOG4105E8G Major facilitator Superfamily D0S46_RS19120 ENOG4105DQ5 transport system permease protein D0S46_RS19125 ENOG4105TVJ transport system, permease D0S46_RS19130 ENOG4105E0A ABC, transporter D0S46_RS19140 ENOG41085A6 mbth domain-containing protein D0S46_RS19145 ENOG4105E93 esterase D0S46_RS19150 ENOG4107RNH Outer membrane receptor FepA D0S46_RS19155 ENOG4108TSE Transferase D0S46_RS19160 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator D0S46_RS19170 ENOG4105C2J ABC transporter D0S46_RS19175 ENOG4105CNN ABC, transporter D0S46_RS19180 ENOG4105DNE Transposase D0S46_RS19185 ENOG4105DKT Transcriptional regulator D0S46_RS19190 ENOG4108HHA Transketolase D0S46_RS19195 ENOG4108IUS Transketolase D0S46_RS19205 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) D0S46_RS19215 ENOG410810E transcriptional regulator, lysR family D0S46_RS19220 ENOG4105CUY Mechanosensitive ion channel D0S46_RS19225 ENOG4108WN0 inhibitor of vertebrate lysozyme D0S46_RS19230 ENOG4105C94 Transporter D0S46_RS19250 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) D0S46_RS19260 ENOG4105DEF Extracellular solute-binding protein, family 5 D0S46_RS19265 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component D0S46_RS19270 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D0S46_RS19275 ENOG4105C3U ABC transporter D0S46_RS19280 ENOG4108JQ7 (ABC) transporter D0S46_RS19300 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) D0S46_RS19305 ENOG4105EMU Dehydrogenase D0S46_RS19315 ENOG4105GBT ABC transporter D0S46_RS19320 ENOG4105DRP amino acid AbC transporter D0S46_RS19325 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) D0S46_RS19335 ENOG4105CHM Aminotransferase D0S46_RS19340 ENOG4105T38 integral membrane protein D0S46_RS19345 ENOG4105CE7 Amidase, hydantoinase carbamoylase family D0S46_RS19360 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D0S46_RS19370 ENOG4108J59 Extracellular solute-binding protein, family 5 D0S46_RS19375 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) D0S46_RS19380 ENOG4108T58 Mg2 transport protein CorA D0S46_RS19405 ENOG4105WQ6 Membrane D0S46_RS19410 ENOG4105HFT AraC family transcriptional regulator D0S46_RS19420 ENOG410630P Transcriptional regulator D0S46_RS19425 ENOG4105MSB protein, conserved in bacteria D0S46_RS19465 ENOG4105CUY Mechanosensitive ion channel D0S46_RS19470 ENOG4105ETE Transcriptional regulator (LacI family D0S46_RS19480 ENOG4105CK5 oxidoreductase D0S46_RS19490 ENOG4105EAA nucleoside D0S46_RS19495 ENOG4105C85 amino acid D0S46_RS19505 ENOG4108NS2 receptor D0S46_RS19510 ENOG4105C26 Dehydrogenase D0S46_RS19515 ENOG4105CJP fad dependent oxidoreductase D0S46_RS19525 ENOG4105CUB amino acid D0S46_RS19540 ENOG4105R48 this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase D0S46_RS19545 ENOG4105DGU Histone deacetylase D0S46_RS19555 ENOG4108UAJ Transcriptional regulator D0S46_RS19565 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) D0S46_RS19595 ENOG4105CPC Aldo Keto reductase D0S46_RS19600 ENOG4105E89 ABC transporter D0S46_RS19605 ENOG4105CH2 amidohydrolase D0S46_RS19625 ENOG4105EHG Permease protein D0S46_RS19630 ENOG4105E0A ABC, transporter D0S46_RS19635 ENOG4105EFX secretion protein, HlyD family D0S46_RS19640 ENOG4105KK7 inner membrane protein YiaW D0S46_RS19650 ENOG4105D7K pfkb domain protein D0S46_RS19655 ENOG4108M0B Sucrose porin D0S46_RS19660 ENOG4105C5Y PTS System D0S46_RS19665 ENOG4108HKT sucrose-6-phosphate hydrolase D0S46_RS19670 ENOG4105WBN Transcriptional regulator (LacI family D0S46_RS19680 ENOG4108HWV )-transporter D0S46_RS19685 ENOG4105C2J ABC transporter D0S46_RS19730 ENOG4105CRK lysyL-tRNA synthetase D0S46_RS19735 ENOG4105DUX Transporter D0S46_RS19740 ENOG4105CXN decarboxylase D0S46_RS19745 ENOG4105D5Q Arginine ornithine antiporter D0S46_RS19750 ENOG4108M3R transcriptional activator CadC D0S46_RS19760 ENOG4105D1S lipid A biosynthesis D0S46_RS19770 ENOG4105BZN citrate synthase D0S46_RS19805 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) D0S46_RS19810 ENOG4105WQ3 Rna-binding protein D0S46_RS19815 ENOG4105C8N cysteinyl-tRNA synthetase D0S46_RS19820 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) D0S46_RS19825 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) D0S46_RS19840 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) D0S46_RS19845 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit D0S46_RS19860 ENOG4105CV6 ABC transporter, permease D0S46_RS19865 ENOG4108I0Y (ABC) transporter D0S46_RS19870 ENOG4108UJV acyl-CoA thioesterase i D0S46_RS19875 ENOG4105E1F short-chain dehydrogenase reductase D0S46_RS19880 ENOG4107QR8 Thioredoxin D0S46_RS19890 ENOG4105C4B ABC transporter, permease D0S46_RS19895 ENOG41083J0 (ABC) transporter D0S46_RS19900 ENOG4107QX8 SPFH domain, Band 7 family protein D0S46_RS19905 ENOG4105G5H Membrane D0S46_RS19910 ENOG4108Z6Z Transcriptional regulator D0S46_RS19915 ENOG4105C59 p-type ATPase D0S46_RS19920 ENOG4105MBR gumn family D0S46_RS19925 ENOG4108Z66 YbaK ebsC protein D0S46_RS19930 ENOG4105CGH 5'-nucleotidase D0S46_RS19935 ENOG4105EU0 Major facilitator Superfamily D0S46_RS19940 ENOG4105CKD glutathione-regulated potassium-efflux system protein D0S46_RS19945 ENOG4107RE1 Inosine-guanosine kinase D0S46_RS19955 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) D0S46_RS19960 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) D0S46_RS19965 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) D0S46_RS19970 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) D0S46_RS19975 ENOG4107QMP dna polymerase iii subunits gamma and tau D0S46_RS19980 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) D0S46_RS19990 ENOG4105WD1 Membrane D0S46_RS19995 ENOG4108URS primosomal replication protein n'' D0S46_RS20000 ENOG4106428 Protein of unknown function (DUF2496) D0S46_RS20005 ENOG4105DNE Transposase D0S46_RS20010 ENOG4105EGS Mechanosensitive ion channel D0S46_RS20015 ENOG4107XI7 Tetr family transcriptional regulator D0S46_RS20020 ENOG4105C1P efflux transporter, rnd family, mfp subunit D0S46_RS20025 ENOG4105BZS acriflavin resistance protein D0S46_RS20030 ENOG4108UKR Biofilm formation regulator YbaJ D0S46_RS20040 ENOG4108UW5 maltose o-acetyltransferase D0S46_RS20045 ENOG4105GSJ Inner membrane protein ylaC D0S46_RS20060 ENOG4105YK5 50S ribosomal protein L36 D0S46_RS20070 ENOG4105ETE Transcriptional regulator (LacI family D0S46_RS20075 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) D0S46_RS20080 ENOG4105CI1 PTS System D0S46_RS20085 ENOG4105C4C beta-galactosidase D0S46_RS20095 ENOG4105EG2 ABC transporter, permease D0S46_RS20105 ENOG4107FKK extracellular solute-binding protein family 1 D0S46_RS20115 ENOG41066DG (EAL) domain protein D0S46_RS20120 ENOG41090EM Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter D0S46_RS20125 ENOG41061MD high-affinity nickel-transporter D0S46_RS20130 ENOG4108VW9 Membrane D0S46_RS20160 ENOG41080UX Methyltransferase D0S46_RS20165 ENOG4108MNP Glycoprotein polysaccharide metabolism D0S46_RS20170 ENOG4105C29 acyl-CoA thioesterase D0S46_RS20175 ENOG4105BZU Histidine kinase D0S46_RS20180 ENOG4108YZA Nitrogen regulatory protein pii D0S46_RS20185 ENOG4105BZ1 (ABC) transporter D0S46_RS20190 ENOG4105BZ1 (ABC) transporter D0S46_RS20195 ENOG4108XM1 transcriptional regulator AsnC family D0S46_RS20205 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) D0S46_RS20210 ENOG4108NFA extracellular solute-binding protein D0S46_RS20215 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) D0S46_RS20220 ENOG4108TGP Thioesterase superfamily protein D0S46_RS20225 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein D0S46_RS20230 ENOG4105EIN peptidylprolyl cis-trans isomerase D0S46_RS20235 ENOG4105K70 DNA-binding protein D0S46_RS20240 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) D0S46_RS20245 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) D0S46_RS20255 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation D0S46_RS20270 ENOG4105M85 Bola protein D0S46_RS20275 ENOG4105IEY (LipO)protein D0S46_RS20280 ENOG4105EYM Major Facilitator superfamily D0S46_RS20285 ENOG4105E2S oxidase) subunit II D0S46_RS20290 ENOG4105BZ9 Cytochrome C oxidase, subunit I D0S46_RS20295 ENOG4105CCU oxidase (Subunit III) D0S46_RS20300 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) D0S46_RS20305 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) D0S46_RS20315 ENOG4107HP6 Transcriptional regulator D0S46_RS20320 ENOG4105E2X shikimate dehydrogenase D0S46_RS20325 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein D0S46_RS20335 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein D0S46_RS20345 ENOG4105D2S major facilitator superfamily D0S46_RS20350 ENOG4105CIB oxidoreductase Domain protein D0S46_RS20355 ENOG4107RDB Major Facilitator D0S46_RS20365 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) D0S46_RS20370 ENOG4107S0N DJ-1 family D0S46_RS20380 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) D0S46_RS20385 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) D0S46_RS20390 ENOG4105CTB Polyprenyl synthetase D0S46_RS20395 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) D0S46_RS20400 ENOG4105CPC Aldo Keto reductase D0S46_RS20405 ENOG4108ZAI phosphatidylglycerophosphatase a D0S46_RS20410 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) D0S46_RS20415 ENOG4107YIM Involved in the transcription termination process (By similarity) D0S46_RS20420 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) D0S46_RS20425 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) D0S46_RS20430 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) D0S46_RS20435 ENOG4108KIC (LipO)protein D0S46_RS20440 ENOG4105DRB nucleoside-specific channel-forming protein D0S46_RS20455 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) D0S46_RS20460 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) D0S46_RS20465 ENOG4105VIE preprotein translocase, subunit YajC D0S46_RS20470 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) D0S46_RS20475 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) D0S46_RS20480 ENOG4108ZYK Acyl carrier protein phosphodiesterase D0S46_RS20485 ENOG4105D3R alkyl hydroperoxide reductase D0S46_RS20490 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia D0S46_RS20505 ENOG4108MGF sugar kinase D0S46_RS20515 ENOG4105CI2 imidazolone-5-propionate hydrolase D0S46_RS20525 ENOG4105CHJ isochorismatase hydrolase D0S46_RS20530 ENOG4105EQ1 Transcriptional regulator D0S46_RS20535 ENOG4107R28 alpha amylase, catalytic region D0S46_RS20540 ENOG4105C85 amino acid D0S46_RS20545 ENOG4105CWM branched-chain amino acid transport system II carrier protein D0S46_RS20550 ENOG4105BZU Histidine kinase D0S46_RS20555 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D0S46_RS20560 ENOG4107RH8 nuclease SbcCD subunit D D0S46_RS20565 ENOG4105EYH Exonuclease D0S46_RS20570 ENOG4105DKQ ROK family D0S46_RS20575 ENOG4105DH7 May be involved in recombination (By similarity) D0S46_RS20580 ENOG4105NBK UPF0345 protein D0S46_RS20585 ENOG4105HBA AroM protein D0S46_RS20590 ENOG4105SS3 D0S46_RS20595 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) D0S46_RS20600 ENOG4105G4C Periplasmic ligand-binding sensor protein D0S46_RS20605 ENOG4108UPT UPF0178 protein D0S46_RS20610 ENOG4105II7 pyrroline-5-carboxylate reductase D0S46_RS20615 ENOG4105VIF phosphate starvation-inducible protein D0S46_RS20620 ENOG4105G6Z alkaline phosphatase D0S46_RS20640 ENOG4105CPF Cell wall formation (By similarity) D0S46_RS20645 ENOG4105UNH Membrane D0S46_RS20650 ENOG4105FR5 inner membrane protein YaiY D0S46_RS20655 ENOG4107QS8 (LipO)protein D0S46_RS20660 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 D0S46_RS20665 ENOG4108RWI nicotinamidase D0S46_RS20670 ENOG4107R6D beta-lactam binding protein AmpH D0S46_RS20675 ENOG4105D52 delta-aminolevulinic acid dehydratase D0S46_RS20680 ENOG4108UK5 Transposase D0S46_RS20690 ENOG4105E2B Taurine dioxygenase D0S46_RS20695 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component D0S46_RS20700 ENOG4108ETV ABC transporter D0S46_RS20705 ENOG4106FTQ Taurine ABC transporter, periplasmic D0S46_RS20710 ENOG4107QK5 Homocysteine s-methyltransferase D0S46_RS20715 ENOG4108IQI permease D0S46_RS20720 ENOG4105C85 amino acid D0S46_RS20725 ENOG4105CPD ethanolamine ammonia-lyase D0S46_RS20730 ENOG4107FQ9 ethanolamine ammonia-lyase D0S46_RS20740 ENOG4105C32 Amino acid ABC transporter (Permease) D0S46_RS20745 ENOG4105CF8 branched-chain amino acid ABC transporter, permease D0S46_RS20750 ENOG4105C0Z ABC transporter D0S46_RS20755 ENOG4108IV0 ABC, transporter D0S46_RS20765 ENOG4105CT1 (ABC) transporter D0S46_RS20770 ENOG4105CDA abc transporter atp-binding protein D0S46_RS20775 ENOG4105EZ7 amino acid ABC transporter D0S46_RS20780 ENOG4105DRP amino acid AbC transporter D0S46_RS20790 ENOG4106PYX Receptor D0S46_RS20795 ENOG4108N3D putative enzyme D0S46_RS20800 ENOG4108NN8 Fimbrial protein D0S46_RS20805 ENOG4108GWT fimbrillin MatB D0S46_RS20810 ENOG4106JB4 Represses expression of the flagellar master operon flhDC, and consequently prevents flagellum biosynthesis and motility. Acts by binding to the regulatory region of the flhDC operon D0S46_RS20820 ENOG4105EHI Phosphonate ABC transporter, periplasmic D0S46_RS20830 ENOG4105S7S phosphonate abc transporter D0S46_RS20855 ENOG4108QBX (LipO)protein D0S46_RS20860 ENOG4105FCK Membrane D0S46_RS20865 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) D0S46_RS20880 ENOG4105C0D helicase D0S46_RS20910 ENOG41061ZR Transcriptional regulator D0S46_RS20915 ENOG4107R0V Pyruvate dehydrogenase D0S46_RS20920 ENOG4105CPP Dehydrogenase, E1 component D0S46_RS20930 ENOG4107QN2 dihydrolipoyl dehydrogenase D0S46_RS20945 ENOG41061GT Aldolase D0S46_RS20955 ENOG4105CMG Carbohydrate kinase D0S46_RS20960 ENOG4105CHR reductase D0S46_RS20965 ENOG4108JQ1 Dehydrogenase D0S46_RS20970 ENOG4105DT3 PTS system, galactitol-specific IIc component D0S46_RS20975 ENOG4108TGY Glutathione S-transferase D0S46_RS20980 ENOG4105DTA methyltransferase D0S46_RS20985 ENOG4105YCT UPF0386 protein D0S46_RS21000 ENOG4105D5U fad dependent oxidoreductase D0S46_RS21005 ENOG4105C26 Dehydrogenase D0S46_RS21010 ENOG4108JPW Aminotransferase D0S46_RS21015 ENOG4105C85 amino acid D0S46_RS21020 ENOG4108PVQ transcriptional regulator D0S46_RS21025 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) D0S46_RS21030 ENOG4105V1F Fermentation respiration switch protein D0S46_RS21035 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) D0S46_RS21040 ENOG4105CIN aminoacyl-histidine dipeptidase D0S46_RS21045 ENOG4108HYG acetyltransferase D0S46_RS21050 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) D0S46_RS21065 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) D0S46_RS21070 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) D0S46_RS21075 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) D0S46_RS21080 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) D0S46_RS21085 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) D0S46_RS21090 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) D0S46_RS21100 ENOG4105F7V ErfK ybiS ycfS ynhG family protein D0S46_RS21105 ENOG4105E7A Glutamine amidotransferase D0S46_RS21110 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) D0S46_RS21115 ENOG4107QPN acyl-Coa dehydrogenase D0S46_RS21120 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase D0S46_RS21125 ENOG4108VP3 Lysine exporter protein (LysE YggA) D0S46_RS21130 ENOG41090KR LysR family transcriptional Regulator D0S46_RS21145 ENOG4107RZZ dna polymerase iii epsilon subunit D0S46_RS21150 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) D0S46_RS21155 ENOG4105D1A Methyltransferase D0S46_RS21160 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) D0S46_RS21165 ENOG4105E9H Lytic Murein transglycosylase D0S46_RS21170 ENOG4105F2W methyltransferase D0S46_RS21185 ENOG4105HEI LysR family (Transcriptional regulator D0S46_RS21190 ENOG4105CV8 reductase D0S46_RS21230 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase D0S46_RS21235 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) D0S46_RS21240 ENOG4108UMI ABC transporter, permease D0S46_RS21245 ENOG4105D01 (LipO)protein D0S46_RS21250 ENOG4108R8X outer membrane lipoprotein D0S46_RS21255 ENOG4108R96 Methyltransferase, YaeB family D0S46_RS21260 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) D0S46_RS21265 ENOG4108UY0 (LipO)protein D0S46_RS21270 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion D0S46_RS21275 ENOG4108YZN class I peptide chain release factor D0S46_RS21280 ENOG4108VWS Yaeq family D0S46_RS21285 ENOG4105W1I UPF0253 protein D0S46_RS21290 ENOG4105M1T rho-binding antiterminator D0S46_RS21295 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) D0S46_RS21300 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase D0S46_RS21305 ENOG4105CXN decarboxylase D0S46_RS21310 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) D0S46_RS21315 ENOG4105C0B DNA polymerase III (alpha subunit) D0S46_RS21320 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) D0S46_RS21325 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) D0S46_RS21330 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) D0S46_RS21335 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) D0S46_RS21340 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) D0S46_RS21345 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) D0S46_RS21350 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane D0S46_RS21355 ENOG4105DZP Membrane-associated zinc metalloprotease D0S46_RS21360 ENOG4105KNE Phosphatidate cytidylyltransferase D0S46_RS21375 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) D0S46_RS21385 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) D0S46_RS21390 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) D0S46_RS21395 ENOG4105CE9 30S ribosomal protein S2 D0S46_RS21400 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) D0S46_RS21405 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) D0S46_RS21410 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) D0S46_RS21415 ENOG4108T8E UPF0325 protein D0S46_RS21420 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR D0S46_RS21425 ENOG4105C0H protease D0S46_RS21430 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein D0S46_RS21435 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) D0S46_RS21440 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) D0S46_RS21445 ENOG4105EN6 Membrane D0S46_RS21450 ENOG4108YX9 iron--sulfur cluster insertion protein erpA D0S46_RS21455 ENOG4105CMQ Chloride channel D0S46_RS21460 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase D0S46_RS21465 ENOG4105S6R Iron-hydroxamate transporter permease subunit D0S46_RS21470 ENOG4105J76 Periplasmic binding protein D0S46_RS21475 ENOG4105E0A ABC, transporter D0S46_RS21480 ENOG4105E0K tonB-dependent siderophore receptor D0S46_RS21485 ENOG4105BZ4 penicillin-binding protein D0S46_RS21575 ENOG4105CQ7 ATP-dependent helicase D0S46_RS21580 ENOG4107XID 2'-5' rna ligase D0S46_RS21585 ENOG4105PW4 Sugar fermentation stimulation protein homolog D0S46_RS21590 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters D0S46_RS21595 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) D0S46_RS21600 ENOG4105DJ0 Poly(A) Polymerase D0S46_RS21605 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase D0S46_RS21610 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) D0S46_RS21615 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) D0S46_RS21620 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) D0S46_RS21625 ENOG4107BJW polysaccharide deacetylase D0S46_RS21630 ENOG4108YTN IIa component D0S46_RS21635 ENOG4105E3A (ABC) transporter D0S46_RS21640 ENOG4105DA5 (ABC) transporter D0S46_RS21645 ENOG41077A9 carbonic anhydrase D0S46_RS21650 ENOG4108UGV hypoxanthine phosphoribosyltransferase D0S46_RS21655 ENOG4105DZG Dehydrogenase D0S46_RS21660 ENOG4105E3B Multicopper oxidase D0S46_RS21665 ENOG4108ZRK uncharacterized protein yacC D0S46_RS21680 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) D0S46_RS21685 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) D0S46_RS21690 ENOG4108ZIG UPF0231 protein D0S46_RS21695 ENOG4107QIJ Aconitate hydratase 2 D0S46_RS21705 ENOG4108NST exported protein D0S46_RS21720 ENOG4107QN2 dihydrolipoyl dehydrogenase D0S46_RS21725 ENOG4107QSN dihydrolipoamide acetyltransferase D0S46_RS21730 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) D0S46_RS21735 ENOG41073TP transcriptional regulator D0S46_RS21740 ENOG4105C85 amino acid D0S46_RS21745 ENOG4105CT4 transporter D0S46_RS21750 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) D0S46_RS21755 ENOG4106A72 regulatory protein AmpE D0S46_RS21760 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase D0S46_RS21765 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase D0S46_RS21770 ENOG4108ZUW Major pilin subunit D0S46_RS21775 ENOG4107QHF type ii secretion system protein e D0S46_RS21780 ENOG4105D7Q type ii secretion system D0S46_RS21785 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) D0S46_RS21790 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) D0S46_RS21795 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) D0S46_RS21800 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) D0S46_RS21805 ENOG4105M6F mutator MutT protein D0S46_RS21810 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving D0S46_RS21815 ENOG4106Q9Y Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) D0S46_RS21820 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) D0S46_RS21825 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) D0S46_RS21830 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) D0S46_RS21835 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) D0S46_RS21845 ENOG4105DFU Cell wall formation (By similarity) D0S46_RS21850 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) D0S46_RS21855 ENOG4105CNI cell division protein FtsW D0S46_RS21865 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) D0S46_RS21870 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) D0S46_RS21875 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) D0S46_RS21880 ENOG4105CJN penicillin-binding protein D0S46_RS21885 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) D0S46_RS21890 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) D0S46_RS21905 ENOG4107B7Y DNA-binding transcriptional regulator FruR D0S46_RS21910 ENOG4108ZP8 Acetolactate synthase small subunit D0S46_RS21915 ENOG4105C7K acetolactate synthase D0S46_RS21925 ENOG41064T2 transcriptional regulator, lysR family D0S46_RS21935 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) D0S46_RS21945 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) D0S46_RS21950 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) D0S46_RS21965 ENOG4105EMV Major Facilitator D0S46_RS21970 ENOG4105FF2 Type I DHQase D0S46_RS21975 ENOG4105C5Q Transcriptional regulator D0S46_RS21980 ENOG4105DJB Major Facilitator Superfamily D0S46_RS21985 ENOG4105S8Q sugar efflux transporter D0S46_RS22005 ENOG4106SMU thiamine transporter membrane protein D0S46_RS22015 ENOG4108KF1 Membrane D0S46_RS22020 ENOG41063TF transcriptional regulator (AraC D0S46_RS22025 ENOG4105EF1 ribulokinase D0S46_RS22030 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) D0S46_RS22035 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase D0S46_RS22040 ENOG4105CQ2 DNA polymerase D0S46_RS22045 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) D0S46_RS22050 ENOG4105D3G Pseudouridine synthase D0S46_RS22065 ENOG4105D2K citrate carrier protein D0S46_RS22070 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism D0S46_RS22075 ENOG4106YYS transcriptional regulatory protein D0S46_RS22080 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) D0S46_RS22085 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) D0S46_RS22095 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) D0S46_RS22100 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) D0S46_RS22110 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) D0S46_RS22115 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) D0S46_RS22125 ENOG4105CKD glutathione-regulated potassium-efflux system protein D0S46_RS22135 ENOG4105M5B (LipO)protein D0S46_RS22140 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain D0S46_RS22145 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain D0S46_RS22155 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) D0S46_RS22160 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) D0S46_RS22165 ENOG4105EXG Transcriptional regulator D0S46_RS22170 ENOG4105KAF membrAne D0S46_RS22175 ENOG4105DU0 nucleoside hydrolase D0S46_RS22180 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) D0S46_RS22185 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase D0S46_RS22190 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) D0S46_RS22200 ENOG4105DTN riboflavin biosynthesis protein ribF D0S46_RS22215 ENOG41063Z6 transcriptional regulator, lysR family D0S46_RS22220 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) D0S46_RS22225 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) D0S46_RS22230 ENOG4105CFG Acts as a chaperone (By similarity) D0S46_RS22235 ENOG4108WTA UPF0412 protein YaaI D0S46_RS22240 ENOG4108QUJ UPF0174 protein YaaW D0S46_RS22245 ENOG4106HK8 GPR1 FUN34 yaaH family protein D0S46_RS22250 ENOG4105CSH Transporter D0S46_RS22255 ENOG4108RIR Molybdenum cofactor biosynthesis protein D0S46_RS22260 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) D0S46_RS22265 ENOG4105BZG amino acid carrier protein D0S46_RS22270 ENOG4105D1Q UPF0246 protein D0S46_RS22280 ENOG4105D98 threonine synthase D0S46_RS22285 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) D0S46_RS22290 ENOG4105CFH Aspartokinase D0S46_RS22300 ENOG4106FVC RNA methyltransferase D0S46_RS22310 ENOG410759A D0S46_RS22315 ENOG41065U4 response regulator D0S46_RS22320 ENOG4105CT7 inner membrane cred family protein D0S46_RS22325 ENOG4105EB3 Histidine kinase D0S46_RS22330 ENOG4105E3W Two component transcriptional regulator (Winged helix family D0S46_RS22335 ENOG4108RH0 Crea protein D0S46_RS22340 ENOG4105UEI Transcriptional Regulator AraC Family D0S46_RS22345 ENOG4105CVJ phosphoglycerate mutase D0S46_RS22350 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) D0S46_RS22355 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) D0S46_RS22360 ENOG4107SC1 transglycosylase D0S46_RS22370 ENOG4105C5H ABC transporter D0S46_RS22375 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase D0S46_RS22380 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) D0S46_RS22385 ENOG4105EAC phosphoserine phosphatase D0S46_RS22395 ENOG41062Z9 Membrane D0S46_RS22400 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) D0S46_RS22415 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) D0S46_RS22425 ENOG4105D9N nucleoside D0S46_RS22430 ENOG4105EYA deoxyribonuclease D0S46_RS22435 ENOG4108NRW Phospholipase, patatin family D0S46_RS22445 ENOG4105K3G Periplasmic Protein D0S46_RS22450 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) D0S46_RS22455 ENOG4105PAD Hydrolase D0S46_RS22460 ENOG4105KEG ribosomal-protein-alanine acetyltransferase D0S46_RS22465 ENOG4108WPU DNA polymerase III subunit psi D0S46_RS22470 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) D0S46_RS22490 ENOG4105YBH Protein of unknown function (DUF1435) D0S46_RS22495 ENOG4106TD9 Diguanylate cyclase D0S46_RS22500 ENOG4108819 ferric iron reductase D0S46_RS22505 ENOG4105CK1 PTS System D0S46_RS22510 ENOG4108UIN ybak prolyl-trna synthetase associated region D0S46_RS22515 ENOG4108T94 DNA-binding transcriptional activator BglJ D0S46_RS22520 ENOG4108N8T regulatoR D0S46_RS22530 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase D0S46_RS22535 ENOG4105DWK Membrane D0S46_RS22540 ENOG4107XM3 UPF0442 protein D0S46_RS22545 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) D0S46_RS22550 ENOG4106CVF DNA replication protein D0S46_RS22555 ENOG4105RI1 glycoprotein receptor D0S46_RS22565 ENOG4105DNE Transposase D0S46_RS22580 ENOG4105F3R pts system mannose fructose sorbose family iid D0S46_RS22585 ENOG4105ETZ PTS System D0S46_RS22590 ENOG4105KPI PTS system sorbose subfamily IIB component D0S46_RS22600 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D0S46_RS22610 ENOG4105XYF acetyltransferase D0S46_RS22615 ENOG4106KNT transcriptional regulator D0S46_RS22620 ENOG4108RTU Aldolase D0S46_RS22625 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 D0S46_RS22655 ENOG4105DG4 malate L-lactate dehydrogenase D0S46_RS22670 ENOG4108V8F Transcriptional regulator, MarR family D0S46_RS22675 ENOG4105ERH Fumarylacetoacetate hydrolase D0S46_RS22685 ENOG4105C26 Dehydrogenase D0S46_RS22690 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase D0S46_RS22705 ENOG4105CNV Aldolase D0S46_RS22715 ENOG4108NKV transcriptional regulator D0S46_RS22720 ENOG4105EFA 4-hydroxyphenylacetate D0S46_RS22725 ENOG4107UWN reductase D0S46_RS22740 ENOG4105D22 carbon starvation protein D0S46_RS22745 ENOG4105VCD cytoplasmic protein D0S46_RS22750 ENOG4105CKI cobalamin synthesis protein D0S46_RS22760 ENOG4105C26 Dehydrogenase D0S46_RS22765 ENOG4105DNE Transposase D0S46_RS22770 ENOG4106AXJ AraC family transcriptional regulator D0S46_RS22780 ENOG4106BRA Membrane D0S46_RS22785 ENOG41083G8 Multidrug resistance protein MdtM D0S46_RS22795 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase D0S46_RS22800 ENOG4105CIZ coA-substrate-specific enzyme activase D0S46_RS22815 ENOG4105EFX secretion protein, HlyD family D0S46_RS22825 ENOG4106DIZ Domain of unknown function (DUF1127) D0S46_RS22830 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D0S46_RS22840 ENOG41064T2 transcriptional regulator, lysR family D0S46_RS22845 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein D0S46_RS22850 ENOG4105CNN ABC, transporter D0S46_RS22855 ENOG4105CNN ABC, transporter D0S46_RS22860 ENOG4105C2J ABC transporter D0S46_RS22865 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator D0S46_RS22875 ENOG4105BZU Histidine kinase D0S46_RS22880 ENOG4105D0S secretion protein (HlyD D0S46_RS22885 ENOG4105CJ1 ABC, transporter D0S46_RS22890 ENOG4105CMI transporter D0S46_RS22925 ENOG4105EZE Cupin 4 family protein D0S46_RS22940 ENOG4105GR3 Histidine kinase D0S46_RS22945 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D0S46_RS22955 ENOG4105ENJ RND efflux system, outer membrane lipoprotein D0S46_RS22960 ENOG410624V efflux system protein D0S46_RS22965 ENOG4105EP1 Efflux transporter rnd family, mfp subunit D0S46_RS22970 ENOG4108IJF Heavy metal efflux pump, CzcA D0S46_RS22980 ENOG4105QNF Outer membrane lipoprotein D0S46_RS22985 ENOG4108XDN Transcriptional regulator D0S46_RS22995 ENOG4107FW0 short-chain dehydrogenase reductase D0S46_RS23010 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase D0S46_RS23030 ENOG4107SEY Conserved Protein D0S46_RS23035 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) D0S46_RS23040 ENOG4105C93 Xylose Isomerase D0S46_RS23045 ENOG4105CT4 transporter D0S46_RS23050 ENOG4105DSG hydrolase family 43 D0S46_RS23070 ENOG4107S6X Glycosyl transferase, family 2 D0S46_RS23130 ENOG4106H3A restriction D0S46_RS23135 ENOG4108YUH D0S46_RS23145 ENOG4107XZC Restriction modification system DNA (Specificity D0S46_RS23150 ENOG4105CVR type I restriction-modification system D0S46_RS23155 ENOG4107SCJ type I restriction enzyme EcoKI subunit R D0S46_RS23175 ENOG41077A9 carbonic anhydrase D0S46_RS23180 ENOG4105CHH sulfate transporter D0S46_RS23185 ENOG4105DQ4 alcohol dehydrogenase D0S46_RS23195 ENOG4105DRS transport system, permease D0S46_RS23200 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) D0S46_RS23205 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D0S46_RS23215 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) D0S46_RS23220 ENOG4105F0H myo-inositol catabolism protein D0S46_RS23230 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) D0S46_RS23235 ENOG4105D7K pfkb domain protein D0S46_RS23240 ENOG4105CHC glucokinase (EC 2.7.1.2) D0S46_RS23265 ENOG4105DH8 myo-inositol catabolism D0S46_RS23270 ENOG4105C26 Dehydrogenase D0S46_RS23280 ENOG4105D7A ATP-binding protein D0S46_RS23285 ENOG4108K5H permease YjgP YjgQ family protein D0S46_RS23290 ENOG4108M8S permease YjgP YjgQ family protein D0S46_RS23300 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) D0S46_RS23305 ENOG4105MYG DNA polymerase iii, chi subunit D0S46_RS23310 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) D0S46_RS23315 ENOG4108MJ3 acetyltransferase D0S46_RS23320 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase D0S46_RS23325 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) D0S46_RS23335 ENOG4105XEP YhcH YjgK YiaL family protein D0S46_RS23350 ENOG4105CXT aspartate transcarbamylase D0S46_RS23355 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) D0S46_RS23360 ENOG4105KME endoribonuclease L-psp D0S46_RS23375 ENOG4105D4X repressor D0S46_RS23380 ENOG4105C5Y PTS System D0S46_RS23385 ENOG4105CG3 alpha amylase, catalytic region D0S46_RS23390 ENOG4105CK1 PTS System D0S46_RS23395 ENOG4105F8D glycoside hydrolase family 4 D0S46_RS23410 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase D0S46_RS23415 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) D0S46_RS23420 ENOG4105K4U addiction module toxin, RelE StbE family D0S46_RS23430 ENOG4105EMD TRANSCRIPTIONal D0S46_RS23435 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) D0S46_RS23450 ENOG41069H0 dihydroorotase EC 3.5.2.3 D0S46_RS23480 ENOG4108XVM Cytochrome b(562) D0S46_RS23485 ENOG4105CMS peptidase U62, modulator of DNA gyrase D0S46_RS23490 ENOG4105N42 UPF0307 protein D0S46_RS23505 ENOG4105DFU Cell wall formation (By similarity) D0S46_RS23510 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 D0S46_RS23515 ENOG41062B0 ABC transporter, permease D0S46_RS23520 ENOG4107R9N ABC transporter D0S46_RS23525 ENOG4105C2J ABC transporter D0S46_RS23530 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator D0S46_RS23535 ENOG4105F0N pyrophosphate phospho-hydrolase D0S46_RS23545 ENOG4108ZHD aig2 family D0S46_RS23550 ENOG4105MA0 exported protein D0S46_RS23555 ENOG4105CFU surface antigen D0S46_RS23565 ENOG4105C37 (CBS) domain D0S46_RS23575 ENOG4105C4C beta-galactosidase D0S46_RS23585 ENOG41061GZ Protein of unknown function (DUF1107) D0S46_RS23590 ENOG4108UUE Transcriptional regulator D0S46_RS23595 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase D0S46_RS23600 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic D0S46_RS23605 ENOG4105KVH Transcriptional regulator D0S46_RS23610 ENOG4105ECR NmrA family D0S46_RS23620 ENOG4105DXC membrane D0S46_RS23625 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) D0S46_RS23635 ENOG4108V1T peptidylprolyl cis-trans isomerase D0S46_RS23640 ENOG4105FHY Opacity-associated protein A D0S46_RS23645 ENOG4105K9Q Binds to the 23S rRNA (By similarity) D0S46_RS23650 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) D0S46_RS23655 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) D0S46_RS23660 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) D0S46_RS23665 ENOG4105KIT UPF0379 protein yjfY D0S46_RS23690 ENOG4106ETB IIa component D0S46_RS23700 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC D0S46_RS23715 ENOG4108MXZ Esterase D0S46_RS23720 ENOG4105WSB biofilm stress and motility protein A D0S46_RS23725 ENOG4105S17 UPF0379 protein yjfN D0S46_RS23730 ENOG4105CSU acyl-Coa dehydrogenase D0S46_RS23735 ENOG4105C2N RNA methyltransferase TrmH family group 3 D0S46_RS23740 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) D0S46_RS23745 ENOG4105KPV Transcriptional regulator D0S46_RS23750 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis D0S46_RS23765 ENOG4105EPW hflc protein D0S46_RS23770 ENOG4107QJR hflk protein D0S46_RS23775 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) D0S46_RS23785 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) D0S46_RS23790 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) D0S46_RS23795 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase D0S46_RS23800 ENOG4105K8N protein family UPF0079, ATPase D0S46_RS23805 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) D0S46_RS23810 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) D0S46_RS23835 ENOG4106TNF Periplasmic binding protein D0S46_RS23840 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) D0S46_RS23850 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) D0S46_RS23855 ENOG4105DJ4 phosphatidylserine decarboxylase D0S46_RS23860 ENOG4105EGS Mechanosensitive ion channel D0S46_RS23865 ENOG4107SC7 Inner membrane transporter yjeM D0S46_RS23870 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) D0S46_RS23875 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) D0S46_RS23880 ENOG4105E33 succinate dehydrogenase D0S46_RS23890 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) D0S46_RS23900 ENOG4105KPY Small multidrug resistance protein D0S46_RS23905 ENOG4106BSU Entericidin B D0S46_RS23915 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) D0S46_RS23920 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein D0S46_RS23940 ENOG4105CW0 outer membrane usher protein D0S46_RS23955 ENOG4108MBX Secretion Protein D0S46_RS23960 ENOG4108JJA ABC, transporter D0S46_RS23970 ENOG4108ZVF (LipO)protein D0S46_RS23975 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) D0S46_RS23985 ENOG4105DVH amino acid D0S46_RS23990 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 D0S46_RS24000 ENOG4108IJ0 Aspartate ammonia-lyase D0S46_RS24005 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter D0S46_RS24015 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) D0S46_RS24020 ENOG4108SIC Transcriptional regulator D0S46_RS24050 ENOG4108TUY outer membrane protein PgaA D0S46_RS24055 ENOG4107BJW polysaccharide deacetylase D0S46_RS24060 ENOG4105CND Glycosyl transferase, family 2 D0S46_RS24080 ENOG4108ZCF integral membrane protein D0S46_RS24085 ENOG4105DVC DnaJ domain protein D0S46_RS24105 ENOG4105CT4 transporter D0S46_RS24110 ENOG4105F8D glycoside hydrolase family 4 D0S46_RS24120 ENOG4108K2B transcriptional regulator D0S46_RS24125 ENOG4105CSH Transporter D0S46_RS24135 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA D0S46_RS24140 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase D0S46_RS24145 ENOG4107RJJ Transcriptional regulator D0S46_RS24150 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG D0S46_RS24155 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH D0S46_RS24160 ENOG4105EKV Phosphonate metabolism protein D0S46_RS24165 ENOG4105FT8 Phosphonate metabolism D0S46_RS24170 ENOG4105ENV phosphonate C-P lyase system protein PhnK D0S46_RS24175 ENOG4105HRV phosphonate c-p lyase system protein phnl D0S46_RS24180 ENOG4105FD8 phosphonate metabolism protein PhnM D0S46_RS24185 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) D0S46_RS24190 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein D0S46_RS24200 ENOG4105BZU Histidine kinase D0S46_RS24205 ENOG4105C2J ABC transporter D0S46_RS24210 ENOG4105CNN ABC, transporter D0S46_RS24215 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator D0S46_RS24245 ENOG41082ND Uncharacterized protein yjcO D0S46_RS24250 ENOG4105CK2 sodium dicarboxylate symporter D0S46_RS24260 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) D0S46_RS24270 ENOG41062QD Membrane D0S46_RS24275 ENOG4107QN1 sodium solute D0S46_RS24290 ENOG4105CW0 outer membrane usher protein D0S46_RS24295 ENOG4108VCD Chaperone D0S46_RS24300 ENOG4105MX3 Fimbrial D0S46_RS24305 ENOG41067MG lrgb family D0S46_RS24315 ENOG4105CMU LysR family (Transcriptional regulator D0S46_RS24320 ENOG4105EEQ Na H antiporter D0S46_RS24325 ENOG4105C7N Xanthine uracil vitamin C permease D0S46_RS24330 ENOG4108K3A Glutathione S-transferase D0S46_RS24335 ENOG4108Z4X TRANSCRIPTIONal D0S46_RS24340 ENOG4108W3Q Transcriptional regulator D0S46_RS24345 ENOG4108M8H domain protein D0S46_RS24355 ENOG4105PMV Membrane D0S46_RS24380 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) D0S46_RS24385 ENOG4105ETE Transcriptional regulator (LacI family D0S46_RS24390 ENOG4105ECY inositol monophosphatase D0S46_RS24405 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane D0S46_RS24420 ENOG4108DMH HTH_ARAC D0S46_RS24425 ENOG4107RNH Outer membrane receptor FepA D0S46_RS24430 ENOG4105E4C Lytic transglycosylase catalytic D0S46_RS24435 ENOG4108UUM single-stranded DNA-binding protein D0S46_RS24445 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) D0S46_RS24450 ENOG4105MSB protein, conserved in bacteria D0S46_RS24455 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme D0S46_RS24465 ENOG4105CGF Aromatic amino acid aminotransferase D0S46_RS24470 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) D0S46_RS24475 ENOG4105CDU Replicative dna helicase D0S46_RS24480 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein D0S46_RS24485 ENOG4105P4Z Phage shock protein G D0S46_RS24490 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) D0S46_RS24500 ENOG4105MYN Zinc uptake regulation protein D0S46_RS24505 ENOG4105VDW Csbd family D0S46_RS24510 ENOG4107R73 Mate efflux family protein D0S46_RS24515 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) D0S46_RS24520 ENOG41080IJ Diacylglycerol kinase D0S46_RS24525 ENOG4105E55 glycerol-3-phosphate acyltransferase D0S46_RS24530 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) D0S46_RS24535 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) D0S46_RS24540 ENOG4107W52 maltose operon periplasmic protein D0S46_RS24545 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) D0S46_RS24550 ENOG4108IJ9 (ABC) transporter D0S46_RS24560 ENOG4107FKK extracellular solute-binding protein family 1 D0S46_RS24565 ENOG4105D56 permease protein D0S46_RS24570 ENOG4105EG2 ABC transporter, permease D0S46_RS24575 ENOG4108VY7 phosphate-starvation-inducible protein PsiE D0S46_RS24580 ENOG4105CEM UPF0597 protein D0S46_RS24595 ENOG4105KME endoribonuclease L-psp D0S46_RS24605 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) D0S46_RS24610 ENOG4107QP8 phosphohexose isomerase D0S46_RS24625 ENOG4105CFH Aspartokinase D0S46_RS24630 ENOG4105C09 Bile acid D0S46_RS24635 ENOG4108ZR5 Conserved Protein D0S46_RS24640 ENOG4105FE9 pseudouridine synthase D0S46_RS24650 ENOG4105EAM Na Pi-cotransporter D0S46_RS24655 ENOG4105C3R Methionine synthase D0S46_RS24660 ENOG41069M3 Transcriptional regulator D0S46_RS24665 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) D0S46_RS24670 ENOG4108I9X Isocitrate lyase D0S46_RS24675 ENOG4107QP3 malate synthase g D0S46_RS24680 ENOG4105CVG Homoserine O-transsuccinylase D0S46_RS24685 ENOG4105K5X acetyltransferase D0S46_RS24720 ENOG4105DC1 bifunctional purine biosynthesis protein purh D0S46_RS24725 ENOG4105C12 Phosphoribosylglycinamide synthetase D0S46_RS24735 ENOG4105BZU Histidine kinase D0S46_RS24740 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism D0S46_RS24745 ENOG4108T8B Protein of unknown function (DUF1481) D0S46_RS24750 ENOG4105K70 DNA-binding protein D0S46_RS24755 ENOG4105R2J Conserved Protein D0S46_RS24760 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) D0S46_RS24765 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) D0S46_RS24770 ENOG4105E09 nadh pyrophosphatase D0S46_RS24775 ENOG4107MNS Has binding activity to the major sigma subunit of RNA polymerase. May be involved in replacement of the RNA polymerase sigma subunit from sigma-70 to sigma-S during the transition from exponential growth to the stationary phase (By similarity) D0S46_RS24780 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) D0S46_RS24785 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) D0S46_RS24790 ENOG4105D06 uba thif-type nad fad binding protein D0S46_RS24795 ENOG4105WHD thiamine biosynthesis protein ThiS D0S46_RS24800 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) D0S46_RS24805 ENOG4105D41 biosynthesis protein thiH D0S46_RS24815 ENOG4106TD9 Diguanylate cyclase D0S46_RS24825 ENOG4105VCP PTS System D0S46_RS24830 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter D0S46_RS24835 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) D0S46_RS24840 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) D0S46_RS24845 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) D0S46_RS24850 ENOG4108VZM 50s ribosomal protein L10 D0S46_RS24860 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) D0S46_RS24865 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) D0S46_RS24870 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) D0S46_RS24875 ENOG4105PM1 preprotein translocase subunit SecE D0S46_RS24885 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) D0S46_RS24910 ENOG4105CS9 pantothenic acid kinase D0S46_RS24915 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase D0S46_RS24920 ENOG4105D4A Cell wall formation (By similarity) D0S46_RS24950 ENOG4108RR8 protoporphyrinogen oxidase D0S46_RS24955 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) D0S46_RS24960 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein D0S46_RS24965 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) D0S46_RS24975 ENOG4108EIM Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities (By similarity) D0S46_RS24980 ENOG4105CHU acetyl-coa acetyltransferase D0S46_RS24985 ENOG4107QK7 reductase D0S46_RS24990 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) D0S46_RS24995 ENOG4105MDZ Transcriptional activator rfaH D0S46_RS25005 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) D0S46_RS25010 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) D0S46_RS25015 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) D0S46_RS25020 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) D0S46_RS25025 ENOG4105JC1 sterol-binding domain protein D0S46_RS25030 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) D0S46_RS25035 ENOG4105CGY Dna recombination protein D0S46_RS25040 ENOG4107SXA Phosphorylase D0S46_RS25045 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) D0S46_RS25050 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) D0S46_RS25055 ENOG4105DZ2 Transcriptional regulator D0S46_RS25060 ENOG4105EMK carboxylate amino acid amine transporter D0S46_RS25065 ENOG4105DQF Hydrolase D0S46_RS25070 ENOG4108EUD Lysophospholipase D0S46_RS25075 ENOG410829K Lysine exporter protein (Lyse ygga) D0S46_RS25085 ENOG4105CCF Lysine exporter protein (Lyse ygga) D0S46_RS25090 ENOG4105C9U ATP-dependent DNA helicase RecQ D0S46_RS25095 ENOG4105HDD phospholipase D0S46_RS25100 ENOG4108VUY thioesterase Superfamily protein D0S46_RS25105 ENOG4105FR1 rard protein D0S46_RS25110 ENOG4107QUT magnesium and cobalt transport protein CorA D0S46_RS25120 ENOG4105C4R Atp-dependent dna helicase D0S46_RS25125 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant D0S46_RS25130 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) D0S46_RS25135 ENOG4105CT0 Protein of unknown function, DUF484 D0S46_RS25145 ENOG4105S7Z (LipO)protein D0S46_RS25150 ENOG4105XQ6 frataxin-like protein D0S46_RS25155 ENOG4107T0K Adenylate cyclase D0S46_RS25160 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) D0S46_RS25165 ENOG41076E6 Uroporphyrinogen-III Synthase D0S46_RS25170 ENOG4105ECF c-methyltransferase D0S46_RS25175 ENOG410601J HemY protein D0S46_RS25200 ENOG4105C85 amino acid D0S46_RS25205 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family D0S46_RS25210 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) D0S46_RS25215 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) D0S46_RS25220 ENOG4105EGZ biosynthesis protein D0S46_RS25225 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase D0S46_RS25230 ENOG4108WJ1 acetyltransferase D0S46_RS25235 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) D0S46_RS25240 ENOG4105C1B dTDP-glucose 4-6-dehydratase D0S46_RS25245 ENOG4107QQG Dehydrogenase D0S46_RS25250 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase D0S46_RS25255 ENOG4105SFE lipopolysaccharide biosynthesis protein D0S46_RS25260 ENOG4105ESV Glycosyl transferase, family 4 D0S46_RS25265 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) D0S46_RS25280 ENOG4105C1J atp-dependent rna helicase D0S46_RS25290 ENOG4105C9X ppx gppa phosphatase D0S46_RS25305 ENOG4108UQV Membrane D0S46_RS25310 ENOG4105C4R Atp-dependent dna helicase D0S46_RS25315 ENOG4105KQ5 peptidylprolyl cis-trans isomerase D0S46_RS25320 ENOG4105KQ5 peptidylprolyl cis-trans isomerase D0S46_RS25325 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase D0S46_RS25330 ENOG4105EMY transcriptional regulator D0S46_RS25335 ENOG4105C7B Threonine dehydratase D0S46_RS25340 ENOG4105C01 Dihydroxy-acid dehydratase D0S46_RS25345 ENOG4105CM2 brancheD-chain amino acid aminotransferase D0S46_RS25350 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit D0S46_RS25365 ENOG4105C0P Mg chelatase subunit ChlI D0S46_RS25370 ENOG4108WFC UPF0438 protein yifE D0S46_RS25425 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) D0S46_RS25430 ENOG4108Y73 Membrane D0S46_RS25435 ENOG4105EJ2 Transcriptional regulator D0S46_RS25440 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) D0S46_RS25445 ENOG4105C5Q Transcriptional regulator D0S46_RS25455 ENOG4105CH7 arginosuccinase D0S46_RS25465 ENOG4105CAS nag kinase D0S46_RS25470 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase D0S46_RS25485 ENOG4108MEK Metal-binding protein YodA D0S46_RS25490 ENOG4106R3P AraC family transcriptional regulator D0S46_RS25495 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) D0S46_RS25500 ENOG4105DCT glycerol dehydrogenase D0S46_RS25505 ENOG4108Q5Y Membrane D0S46_RS25510 ENOG4105SYT Methylenetetrahydrofolate reductase D0S46_RS25515 ENOG4105CN8 Transcriptional regulator D0S46_RS25520 ENOG4108Z8I decarboxylase D0S46_RS25525 ENOG4105CGH 5'-nucleotidase D0S46_RS25535 ENOG4105CFH Aspartokinase D0S46_RS25540 ENOG4105C28 cystathionine D0S46_RS25545 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) D0S46_RS25550 ENOG4105VFB Binds the 23S rRNA (By similarity) D0S46_RS25555 ENOG4105C25 Primosomal protein n' D0S46_RS25560 ENOG4105ETE Transcriptional regulator (LacI family D0S46_RS25565 ENOG41063M6 Cell Division Protein D0S46_RS25570 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) D0S46_RS25580 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase D0S46_RS25585 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) D0S46_RS25590 ENOG4105CTQ phosphohexokinase D0S46_RS25595 ENOG41076HS cation diffusion facilitator family transporter D0S46_RS25600 ENOG4105FMW periplasmic D0S46_RS25605 ENOG4105E3W Two component transcriptional regulator (Winged helix family D0S46_RS25610 ENOG4105E0F Histidine kinase D0S46_RS25615 ENOG4108RPX mosc domain containing protein D0S46_RS25620 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) D0S46_RS25625 ENOG4107YRA Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) (By similarity) D0S46_RS25630 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) D0S46_RS25635 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) D0S46_RS25645 ENOG4105DET Rhamnulokinase D0S46_RS25650 ENOG4105DKG l-rhamnose isomerase D0S46_RS25655 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) D0S46_RS25660 ENOG4105D4B ABC, transporter D0S46_RS25665 ENOG4105C2J ABC transporter D0S46_RS25670 ENOG4105CNN ABC, transporter D0S46_RS25675 ENOG4105CNN ABC, transporter D0S46_RS25680 ENOG4105C0A alcohol dehydrogenase D0S46_RS25690 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) D0S46_RS25725 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) D0S46_RS25745 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein D0S46_RS25750 ENOG4108MG3 formate dehydrogenase D0S46_RS25755 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) D0S46_RS25765 ENOG41068KX affects formate dehydrogenase-N D0S46_RS25775 ENOG4105SUU thioesterase domain D0S46_RS25780 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) D0S46_RS25785 ENOG4107S2Z UPF0761 membrane protein D0S46_RS25790 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 D0S46_RS25795 ENOG4105CI3 gtp-binding protein typa D0S46_RS25805 ENOG4105C5F glutamine synthetase D0S46_RS25810 ENOG4105CUX Signal transduction histidine kinase D0S46_RS25815 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D0S46_RS25820 ENOG4105D4P Coproporphyrinogen iii oxidase D0S46_RS25830 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) D0S46_RS25835 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) D0S46_RS25840 ENOG4105C2M dna polymerase I D0S46_RS25850 ENOG4106HNH Acyl-transferase D0S46_RS25855 ENOG4108Z33 Thiol disulfide Interchange Protein D0S46_RS25860 ENOG4105E27 serine threonine protein kinase D0S46_RS25865 ENOG4105PC1 Conserved Protein D0S46_RS25870 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) D0S46_RS25875 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b D0S46_RS25905 ENOG4107EJG GntR family transcriptional regulator D0S46_RS25910 ENOG4105C0R drug resistance transporter emrb qaca subfamily D0S46_RS25915 ENOG4105ETE Transcriptional regulator (LacI family D0S46_RS25920 ENOG4108RVA ribokinase D0S46_RS25925 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator D0S46_RS25930 ENOG4105CNN ABC, transporter D0S46_RS25935 ENOG4105C2J ABC transporter D0S46_RS25945 ENOG4105DFH Transport of potassium into the cell (By similarity) D0S46_RS25960 ENOG4105CU9 asparagine synthetase A D0S46_RS25965 ENOG4108VVK transcriptional Regulator, AsnC D0S46_RS25970 ENOG4105QTB Flavodoxin D0S46_RS25975 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) D0S46_RS25980 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) D0S46_RS25985 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation D0S46_RS26005 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) D0S46_RS26010 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) D0S46_RS26015 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) D0S46_RS26020 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) D0S46_RS26025 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) D0S46_RS26030 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) D0S46_RS26035 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) D0S46_RS26130 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) D0S46_RS26135 ENOG4105C8U phosphate abc transporter D0S46_RS26140 ENOG4105E2Z phosphate ABC transporter (Permease D0S46_RS26145 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) D0S46_RS26165 ENOG4105DYC esterase D0S46_RS26170 ENOG4107VKM 6-phosphogluconolactonase D0S46_RS26175 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 D0S46_RS26185 ENOG4105C7N Xanthine uracil vitamin C permease D0S46_RS26190 ENOG4108YYH Nadph-dependent fmn reductase D0S46_RS26195 ENOG4105E8Q phosphopantetheinyl transferase D0S46_RS26205 ENOG4105C2C drug resistance transporter, Bcr CflA D0S46_RS26215 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) D0S46_RS26225 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins D0S46_RS26230 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) D0S46_RS26240 ENOG4105VG0 50S ribosomal protein l34 D0S46_RS26255 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) D0S46_RS26260 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) D0S46_RS26265 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D0S46_RS26270 ENOG410667J hydrolase D0S46_RS26285 ENOG4105EMF GntR family transcriptional regulator D0S46_RS26290 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 D0S46_RS26295 ENOG4108RTU Aldolase D0S46_RS26300 ENOG4105CXK mandelate racemase muconate lactonizing D0S46_RS26305 ENOG4105DJB Major Facilitator Superfamily D0S46_RS26310 ENOG4105D99 atp gtp-binding protein D0S46_RS26315 ENOG4105R2A (LipO)protein D0S46_RS26330 ENOG4105F5P DNA-damage-inducible protein d D0S46_RS26335 ENOG4105D0C transport protein D0S46_RS26340 ENOG4105FDP GntR family transcriptional regulator D0S46_RS26345 ENOG4105CI1 PTS System D0S46_RS26350 ENOG4105F8D glycoside hydrolase family 4 D0S46_RS26355 ENOG4105VG5 Membrane D0S46_RS26360 ENOG4105JP4 Inner membrane protein yidG D0S46_RS26380 ENOG4105W8I Transcriptional regulator D0S46_RS26385 ENOG4105E5M Multidrug resistance protein D D0S46_RS26410 ENOG4105C7K acetolactate synthase D0S46_RS26415 ENOG4105M71 acetolactate synthase 1 regulatory subunit D0S46_RS26420 ENOG4108KX4 response regulator D0S46_RS26425 ENOG4105BZU Histidine kinase D0S46_RS26430 ENOG4105CXY transporter D0S46_RS26435 ENOG4105CXY transporter D0S46_RS26440 ENOG4108SAJ Protein of unknown function (DUF1198) D0S46_RS26460 ENOG4108KAZ Involved in phosphonate degradation (By similarity) D0S46_RS26465 ENOG4107STF Involved in phosphonate degradation (By similarity) D0S46_RS26475 ENOG4106S9K Transcriptional regulator D0S46_RS26490 ENOG4108MP3 ABC transporter, permease D0S46_RS26500 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) D0S46_RS26505 ENOG4105VCP PTS System D0S46_RS26510 ENOG4105CK1 PTS System D0S46_RS26520 ENOG4105ETE Transcriptional regulator (LacI family D0S46_RS26525 ENOG4105D2S major facilitator superfamily D0S46_RS26535 ENOG4107F9Y LysR family transcriptional regulator D0S46_RS26545 ENOG4105JSC dimethylmenaquinone methyltransferase D0S46_RS26560 ENOG4105T8A Uncharacterized protein YicS D0S46_RS26565 ENOG4108UZ3 Transporter D0S46_RS26570 ENOG4108EKE The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6-anhydro ring (By similarity) D0S46_RS26575 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate D0S46_RS26580 ENOG4105C2C drug resistance transporter, Bcr CflA D0S46_RS26585 ENOG4105ENJ RND efflux system, outer membrane lipoprotein D0S46_RS26590 ENOG4105BZS acriflavin resistance protein D0S46_RS26595 ENOG4105C1P efflux transporter, rnd family, mfp subunit D0S46_RS26615 ENOG410630P Transcriptional regulator D0S46_RS26625 ENOG4105CR8 Transcriptional regulator D0S46_RS26650 ENOG4105D01 (LipO)protein D0S46_RS26665 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein D0S46_RS26795 ENOG4105T95 Thiol disulfide interChange protein D0S46_RS26830 ENOG4105E5H Transposase D0S46_RS26835 ENOG4108YXQ IS66 Orf2 family protein D0S46_RS26865 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) D0S46_RS26880 ENOG4105CAU Arsenical resistance protein, ArsH D0S46_RS26950 ENOG4105KF5 hemolysin expression-modulating protein D0S46_RS26995 ENOG4105D0M Protease HtpX homolog D0S46_RS27015 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit D0S46_RS27020 ENOG4105VN1 Heat shock protein D0S46_RS27095 ENOG4108BUD transposase D0S46_RS27110 ENOG4105EQR Transposase IS116 IS110 IS902 D0S46_RS27140 ENOG4108JQ6 ABC transporter D0S46_RS27155 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component D0S46_RS27160 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D0S46_RS27190 ENOG4108SF5 RNA Polymerase D0S46_RS27195 ENOG4108S3W Anti-feci sigma factor, fecr D0S46_RS27200 ENOG4105GAV receptor D0S46_RS27205 ENOG4108HUF Transporter D0S46_RS27210 ENOG4105DQ5 transport system permease protein D0S46_RS27215 ENOG4108IHU transport system permease protein D0S46_RS27220 ENOG4105E0A ABC, transporter D0S46_RS27225 ENOG4108YXQ IS66 Orf2 family protein D0S46_RS27240 ENOG4105EQR Transposase IS116 IS110 IS902 D0S46_RS27245 ENOG4105CIS alcohol dehydrogenase D0S46_RS27255 ENOG4105ETE Transcriptional regulator (LacI family D0S46_RS27265 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) D0S46_RS27300 ENOG4106CQM replication D0S46_RS27325 ENOG4105E5H Transposase D0S46_RS27330 ENOG4108YXQ IS66 Orf2 family protein D0S46_RS27385 ENOG4105DZR Type I site-specific deoxyribonuclease D0S46_RS27390 ENOG4106RHG Yeca family D0S46_RS27415 ENOG4107CBI conjugal transfer fertility inhibition protein D0S46_RS27640 ENOG4108Z3N Transcriptional regulator D0S46_RS27685 ENOG41074AV Hok/gef family D0S46_RS27795 ENOG4105EKQ RNA-directed DNA polymerase D0S46_RS27840 ENOG4105EQR Transposase IS116 IS110 IS902 D0S46_RS27915 ENOG4108BUD transposase D0S46_RS28005 ENOG4108BUD transposase D0S46_RS28035 ENOG4108BUD transposase D0S46_RS28105 ENOG4105EKQ RNA-directed DNA polymerase D0S46_RS28145 ENOG41074AV Hok/gef family D0S46_RS28185 ENOG4105D7V transposase D0S46_RS28190 ENOG4105D7V transposase D0S46_RS28200 ENOG4105K4U addiction module toxin, RelE StbE family D0S46_RS28210 ENOG4105C4R Atp-dependent dna helicase D0S46_RS28315 ENOG4105EKQ RNA-directed DNA polymerase D0S46_RS28325 ENOG4105KF5 hemolysin expression-modulating protein D0S46_RS28350 ENOG4106JVB Replication Protein D0S46_RS28355 ENOG4105EQR Transposase IS116 IS110 IS902 D0S46_RS28425 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) D0S46_RS28470 ENOG4108BUD transposase D0S46_RS28510 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase D0S46_RS28515 ENOG4105EPC oxidoreductase D0S46_RS28520 ENOG4105VF7 tolerance protein D0S46_RS28525 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) D0S46_RS28550 ENOG4105F9F transposase D0S46_RS28565 ENOG4108BUD transposase D0S46_RS28585 ENOG4108X6F Transcriptional regulator MerD D0S46_RS28600 ENOG4105XIV Mercuric transport protein, periplasmic component D0S46_RS28685 ENOG4108M24 von Willebrand factor, type A D0S46_RS28690 ENOG4108M24 von Willebrand factor, type A D0S46_RS28700 ENOG4108M24 von Willebrand factor, type A D0S46_RS28720 ENOG4105DAX Pfam:DUF2983 D0S46_RS28860 ENOG4108YXQ IS66 Orf2 family protein D0S46_RS28865 ENOG4105E5H Transposase D0S46_RS28870 ENOG4105GR3 Histidine kinase D0S46_RS28875 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D0S46_RS28880 ENOG4108PG2 copper resistance D0S46_RS28885 ENOG4105JDN Copper resistance protein D0S46_RS28890 ENOG4105VR0 copper resistance D0S46_RS28895 ENOG4105E3B Multicopper oxidase D0S46_RS28905 ENOG4105DR5 peptidase D0S46_RS28935 ENOG410624V efflux system protein D0S46_RS28970 ENOG4108YXQ IS66 Orf2 family protein D0S46_RS28975 ENOG4105E5H Transposase D0S46_RS29005 ENOG4105C94 Transporter D0S46_RS29015 ENOG4108M8H domain protein D0S46_RS29040 ENOG410620I Diguanylate cyclase D0S46_RS29045 ENOG4108BUD transposase D0S46_RS29065 ENOG4108BUD transposase D0S46_RS29075 ENOG4108BUD transposase D0S46_RS29175 ENOG4106JVB Replication Protein D0S46_RS29220 ENOG4105XPH Ferredoxin D0S46_RS29275 ENOG4106CVF DNA replication protein D0S46_RS29520 ENOG4105D7V transposase D0S46_RS29640 ENOG4106D80 Uncharacterized protein YhaL D0S46_RS30005 ENOG4107VK2 coenzyme PQQ biosynthesis protein PqqF D0S46_RS30070 ENOG4105CNT hydrolase family 2 D0S46_RS30155 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) D0S46_RS30200 ENOG4107QQB Ribonuclease E D0S46_RS30250 ENOG4105CGP Urocanate hydratase D0S46_RS30275 ENOG4105DKW ABC transporter D0S46_RS30525 ENOG4106FIY