locus-tag	class	description
D0S46_RS00035	COG2211	Major facilitator Superfamily
D0S46_RS00040	COG1501	Belongs to the glycosyl hydrolase 31 family
D0S46_RS00050	COG1486	melibiose metabolic process
D0S46_RS00055	COG1263	PTS System
D0S46_RS00055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0S46_RS00060	COG2982	Protein involved in outer membrane biogenesis
D0S46_RS00065	COG2233	PERMEase
D0S46_RS00070	COG0786	glutamate:sodium symporter activity
D0S46_RS00090	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
D0S46_RS00115	COG3152	Membrane
D0S46_RS00125	COG1494	fructose-1,6-bisphosphatase
D0S46_RS00130	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D0S46_RS00135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D0S46_RS00140	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D0S46_RS00160	COG2860	membrane
D0S46_RS00170	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D0S46_RS00170	COG2169	Transcriptional regulator
D0S46_RS00175	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D0S46_RS00180	COG1561	YicC-like family, N-terminal region
D0S46_RS00200	COG1131	(ABC) transporter
D0S46_RS00205	COG0842	Transport permease protein
D0S46_RS00235	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D0S46_RS00270	COG1519	Transferase
D0S46_RS00275	COG1216	Glycosyl transferase, family 2
D0S46_RS00280	COG0438	transferase activity, transferring glycosyl groups
D0S46_RS00290	COG0859	PFAM glycosyl transferase family 9
D0S46_RS00315	COG0859	PFAM glycosyl transferase family 9
D0S46_RS00330	COG0156	8-amino-7-oxononanoate synthase activity
D0S46_RS00340	COG0463	Glycosyl transferase, family 2
D0S46_RS00345	COG2861	carbohydrate metabolic process
D0S46_RS00350	COG4942	peptidase
D0S46_RS00360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D0S46_RS00365	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D0S46_RS00385	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D0S46_RS00395	COG2186	Transcriptional regulator
D0S46_RS00415	COG3722	fumarate hydratase activity
D0S46_RS00435	COG0625	glutathione transferase activity
D0S46_RS00445	COG3276	selenocysteine insertion sequence binding
D0S46_RS00450	COG1414	Transcriptional regulator
D0S46_RS00455	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D0S46_RS00460	COG3977	Valine--pyruvate aminotransferase
D0S46_RS00465	COG0366	Alpha amylase catalytic
D0S46_RS00475	COG2992	FlgJ-related protein
D0S46_RS00480	COG1609	Transcriptional regulator
D0S46_RS00480	COG2207	Transcriptional regulator
D0S46_RS00485	COG4214	carbohydrate transport
D0S46_RS00495	COG4213	ABC transporter substrate-binding protein
D0S46_RS00515	COG4682	membrane
D0S46_RS00520	COG4682	membrane
D0S46_RS00525	COG3274	enterobacterial common antigen metabolic process
D0S46_RS00565	COG1278	Cold shock
D0S46_RS00570	COG2944	sequence-specific DNA binding
D0S46_RS00575	COG2814	Major facilitator Superfamily
D0S46_RS00600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0S46_RS00610	COG1609	Transcriptional regulator
D0S46_RS00615	COG2885	chlorophyll binding
D0S46_RS00620	COG0243	molybdopterin cofactor binding
D0S46_RS00625	COG0456	acetyltransferase
D0S46_RS00630	COG2818	Glycosylase
D0S46_RS00635	COG5571	outer membrane autotransporter
D0S46_RS00640	COG2223	nitrite transmembrane transporter activity
D0S46_RS00670	COG0747	negative chemotaxis
D0S46_RS00675	COG0601	transmembrane transport
D0S46_RS00680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0S46_RS00685	COG0444	Belongs to the ABC transporter superfamily
D0S46_RS00690	COG4608	Belongs to the ABC transporter superfamily
D0S46_RS00705	COG2894	cell division
D0S46_RS00715	COG1215	transferase activity, transferring glycosyl groups
D0S46_RS00720	COG0457	Tetratricopeptide repeat
D0S46_RS00735	COG2194	sulfuric ester hydrolase activity
D0S46_RS00765	COG1215	transferase activity, transferring glycosyl groups
D0S46_RS00770	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
D0S46_RS00775	COG3118	belongs to the thioredoxin family
D0S46_RS00775	COG0457	Tetratricopeptide repeat
D0S46_RS00780	COG2199	diguanylate cyclase activity
D0S46_RS00780	COG2200	EAL domain
D0S46_RS00795	COG0612	Peptidase, M16
D0S46_RS00810	COG2982	Protein involved in outer membrane biogenesis
D0S46_RS00815	COG0477	Major facilitator Superfamily
D0S46_RS00820	COG1295	ribonuclease BN
D0S46_RS00825	COG0583	DNA-binding transcription factor activity
D0S46_RS00830	COG1028	Short-chain dehydrogenase reductase Sdr
D0S46_RS00835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0S46_RS00845	COG1454	alcohol dehydrogenase
D0S46_RS00855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D0S46_RS00860	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D0S46_RS00865	COG0671	phosphoesterase, PA-phosphatase related
D0S46_RS00885	COG0589	response to stress
D0S46_RS00895	COG0306	phosphate transporter
D0S46_RS00900	COG2081	HI0933 family
D0S46_RS00925	COG4372	Transposase
D0S46_RS00930	COG3436	PFAM IS66 Orf2 family protein
D0S46_RS00950	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
D0S46_RS00955	COG1196	nuclear chromosome segregation
D0S46_RS00985	COG2239	Acts as a magnesium transporter
D0S46_RS01000	COG1124	(ABC) transporter
D0S46_RS01010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0S46_RS01015	COG0601	transmembrane transport
D0S46_RS01020	COG0747	negative chemotaxis
D0S46_RS01035	COG3479	Phenolic acid decarboxylase
D0S46_RS01075	COG0628	permease
D0S46_RS01080	COG0477	Major facilitator Superfamily
D0S46_RS01090	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D0S46_RS01105	COG3714	YhhN family
D0S46_RS01115	COG3776	membrane
D0S46_RS01120	COG0742	ribosomal rna small subunit methyltransferase
D0S46_RS01125	COG0552	protein localization to endoplasmic reticulum
D0S46_RS01130	COG2884	Cell division ATP-binding protein ftsE
D0S46_RS01135	COG2177	Part of the ABC transporter FtsEX involved in
D0S46_RS01150	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D0S46_RS01165	COG0683	leucine binding
D0S46_RS01180	COG0683	leucine binding
D0S46_RS01185	COG0559	Belongs to the binding-protein-dependent transport system permease family
D0S46_RS01235	COG0584	glycerophosphoryl diester phosphodiesterase
D0S46_RS01245	COG0405	Gamma-glutamyltransferase
D0S46_RS01250	COG1247	-acetyltransferase
D0S46_RS01260	COG0673	inositol 2-dehydrogenase activity
D0S46_RS01265	COG1741	Belongs to the pirin family
D0S46_RS01270	COG1609	Transcriptional regulator
D0S46_RS01275	COG3265	gluconokinase activity
D0S46_RS01280	COG2610	gluconate transmembrane transporter activity
D0S46_RS01290	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D0S46_RS01315	COG0058	SHG alpha-glucan phosphorylase activity
D0S46_RS01320	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D0S46_RS01335	COG1349	DNA-binding transcription factor activity
D0S46_RS01350	COG0058	SHG alpha-glucan phosphorylase activity
D0S46_RS01355	COG1640	4-alpha-glucanotransferase
D0S46_RS01360	COG2610	gluconate transmembrane transporter activity
D0S46_RS01370	COG1040	competence protein
D0S46_RS01395	COG1918	ferrous iron import across plasma membrane
D0S46_RS01400	COG2183	response to ionizing radiation
D0S46_RS01405	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D0S46_RS01410	COG0745	RESPONSE REGULATOR receiver
D0S46_RS01430	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D0S46_RS01435	COG1011	Hydrolase
D0S46_RS01445	COG0494	nUDIX hydrolase
D0S46_RS01450	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D0S46_RS01475	COG4796	Type ii and iii secretion system protein
D0S46_RS01495	COG3266	domain, Protein
D0S46_RS01500	COG0338	D12 class N6 adenine-specific DNA methyltransferase
D0S46_RS01505	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D0S46_RS01530	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D0S46_RS01535	COG0402	S-adenosylhomocysteine deaminase activity
D0S46_RS01540	COG0738	Major facilitator superfamily
D0S46_RS01565	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D0S46_RS01570	COG1289	transmembrane transporter activity
D0S46_RS01585	COG1765	OsmC-like protein
D0S46_RS01590	COG3954	Phosphoribulokinase
D0S46_RS01600	COG0429	hydrolase of the alpha beta-hydrolase fold
D0S46_RS01610	COG0488	(ABC) transporter
D0S46_RS01630	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
D0S46_RS01635	COG1047	Peptidyl-prolyl cis-trans
D0S46_RS01645	COG0545	Peptidyl-prolyl cis-trans isomerase
D0S46_RS01650	COG2964	Protein conserved in bacteria
D0S46_RS01710	COG0051	transcription antitermination factor activity, RNA binding
D0S46_RS01735	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D0S46_RS01750	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D0S46_RS01815	COG0201	protein transport
D0S46_RS01840	COG0202	RNA polymerase activity
D0S46_RS01855	COG0789	Transcriptional regulator
D0S46_RS01860	COG3036	rescue of stalled ribosome
D0S46_RS01890	COG0758	DNA mediated transformation
D0S46_RS01900	COG0551	DNA topoisomerase type I activity
D0S46_RS01920	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D0S46_RS01960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0S46_RS01965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0S46_RS01970	COG1309	transcriptional regulator
D0S46_RS01995	COG4145	pantothenate transmembrane transporter activity
D0S46_RS02000	COG3924	membrane
D0S46_RS02005	COG0439	Biotin carboxylase
D0S46_RS02010	COG0511	ligase activity, forming carbon-carbon bonds
D0S46_RS02040	COG2200	EAL domain
D0S46_RS02040	COG2199	diguanylate cyclase activity
D0S46_RS02050	COG1077	Cell shape determining protein MreB Mrl
D0S46_RS02055	COG1792	Involved in formation and maintenance of cell shape
D0S46_RS02060	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
D0S46_RS02070	COG1530	ribonuclease E activity
D0S46_RS02075	COG3164	Protein of unknown function
D0S46_RS02080	COG0312	modulator of DNA gyrase
D0S46_RS02085	COG0583	DNA-binding transcription factor activity
D0S46_RS02100	COG1289	transmembrane transporter activity
D0S46_RS02105	COG2732	(Barnase) inhibitor
D0S46_RS02140	COG0471	metal ion transport
D0S46_RS02145	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
D0S46_RS02150	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D0S46_RS02175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D0S46_RS02180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D0S46_RS02185	COG3105	Protein conserved in bacteria
D0S46_RS02190	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D0S46_RS02210	COG0625	glutathione transferase activity
D0S46_RS02215	COG2969	positive regulation of protein catabolic process
D0S46_RS02225	COG0493	'glutamate synthase
D0S46_RS02230	COG0067	glutamate synthase
D0S46_RS02230	COG0069	glutamate synthase activity
D0S46_RS02230	COG0070	glutamate synthase
D0S46_RS02240	COG1242	4 iron, 4 sulfur cluster binding
D0S46_RS02245	COG2271	Major facilitator Superfamily
D0S46_RS02250	COG1063	alcohol dehydrogenase
D0S46_RS02255	COG1312	Catalyzes the dehydration of D-mannonate
D0S46_RS02260	COG0784	Response regulator, receiver
D0S46_RS02260	COG2198	Histidine kinase
D0S46_RS02260	COG5002	protein histidine kinase activity
D0S46_RS02265	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
D0S46_RS02270	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D0S46_RS02275	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0S46_RS02285	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0S46_RS02290	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D0S46_RS02295	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D0S46_RS02300	COG1137	ATPase activity
D0S46_RS02305	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
D0S46_RS02310	COG3117	lipopolysaccharide transmembrane transporter activity
D0S46_RS02315	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D0S46_RS02325	COG0530	calcium, potassium:sodium antiporter activity
D0S46_RS02335	COG1127	ABC transporter
D0S46_RS02340	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D0S46_RS02345	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D0S46_RS02350	COG2854	intermembrane phospholipid transfer
D0S46_RS02355	COG3113	response to antibiotic
D0S46_RS02360	COG5007	Belongs to the BolA IbaG family
D0S46_RS02370	COG3423	Transcriptional regulator
D0S46_RS02375	COG0142	geranyltranstransferase activity
D0S46_RS02390	COG0697	spore germination
D0S46_RS02400	COG2027	D-alanyl-D-alanine carboxypeptidase
D0S46_RS02410	COG1534	Rna-binding protein
D0S46_RS02425	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D0S46_RS02430	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D0S46_RS02440	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D0S46_RS02480	COG0195	Participates in both transcription termination and antitermination
D0S46_RS02530	COG0814	amino acid
D0S46_RS02535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D0S46_RS02540	COG0826	peptidase U32
D0S46_RS02545	COG0826	peptidase U32
D0S46_RS02550	COG3154	lipid carrier protein
D0S46_RS02555	COG3153	acetyltransferase
D0S46_RS02570	COG0693	protein deglycase activity
D0S46_RS02575	COG0702	epimerase
D0S46_RS02580	COG0701	Predicted permease
D0S46_RS02585	COG2823	Periplasmic or secreted lipoprotein
D0S46_RS02605	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D0S46_RS02610	COG2721	sulfolactate sulfo-lyase activity
D0S46_RS02615	COG2271	Major facilitator Superfamily
D0S46_RS02625	COG2084	Dehydrogenase
D0S46_RS02630	COG1929	Belongs to the glycerate kinase type-1 family
D0S46_RS02650	COG1741	Belongs to the pirin family
D0S46_RS02655	COG0583	DNA-binding transcription factor activity
D0S46_RS02660	COG3152	Membrane
D0S46_RS02665	COG0435	Glutathione S-transferase
D0S46_RS02670	COG2259	Doxx family
D0S46_RS02680	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
D0S46_RS02685	COG4575	ribosome binding
D0S46_RS02690	COG1422	Protein of unknown function (DUF1090)
D0S46_RS02700	COG0586	Pfam SNARE associated Golgi protein
D0S46_RS02710	COG2186	Transcriptional regulator
D0S46_RS02715	COG2271	Major facilitator Superfamily
D0S46_RS02725	COG2721	sulfolactate sulfo-lyase activity
D0S46_RS02740	COG0861	Integral membrane protein TerC family
D0S46_RS02745	COG0673	inositol 2-dehydrogenase activity
D0S46_RS02750	COG1451	nucleotide metabolic process
D0S46_RS02770	COG1902	pentaerythritol trinitrate reductase activity
D0S46_RS02770	COG0446	pyridine nucleotide-disulphide oxidoreductase
D0S46_RS02825	COG1695	Transcriptional regulator
D0S46_RS02830	COG2375	cellular response to nickel ion
D0S46_RS02845	COG1461	Dihydroxyacetone kinase
D0S46_RS02850	COG2376	Dihydroxyacetone kinase
D0S46_RS02920	COG3247	response to pH
D0S46_RS02930	COG2205	protein histidine kinase activity
D0S46_RS02930	COG2198	Histidine kinase
D0S46_RS02930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0S46_RS02930	COG0784	Response regulator, receiver
D0S46_RS02935	COG2197	response regulator
D0S46_RS02960	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D0S46_RS02965	COG0358	DNA primase activity
D0S46_RS02970	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D0S46_RS03040	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D0S46_RS03055	COG4991	sh3 domain protein
D0S46_RS03060	COG3025	triphosphatase activity
D0S46_RS03080	COG2960	long-chain fatty acid transporting porin activity
D0S46_RS03095	COG3384	dioxygenase
D0S46_RS03100	COG0754	glutathionylspermidine amidase activity
D0S46_RS03115	COG0494	nUDIX hydrolase
D0S46_RS03120	COG3151	Protein conserved in bacteria
D0S46_RS03125	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D0S46_RS03130	COG3150	esterase
D0S46_RS03140	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
D0S46_RS03145	COG2249	NAD(P)H dehydrogenase (quinone) activity
D0S46_RS03150	COG0642	Histidine kinase
D0S46_RS03160	COG3111	PFAM Bacterial OB fold (BOF) protein
D0S46_RS03165	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
D0S46_RS03175	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D0S46_RS03180	COG0204	Acyl-transferase
D0S46_RS03185	COG2132	Multicopper oxidase
D0S46_RS03190	COG1032	radical SAM domain protein
D0S46_RS03200	COG0656	L-ascorbic acid biosynthetic process
D0S46_RS03205	COG1979	alcohol dehydrogenase
D0S46_RS03210	COG2207	Transcriptional regulator
D0S46_RS03215	COG0586	Pfam SNARE associated Golgi protein
D0S46_RS03220	COG0626	cystathionine gamma-synthase activity
D0S46_RS03235	COG0848	biopolymer transport protein
D0S46_RS03240	COG2211	Major facilitator Superfamily
D0S46_RS03265	COG0625	glutathione transferase activity
D0S46_RS03275	COG0754	glutathionylspermidine amidase activity
D0S46_RS03280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0S46_RS03300	COG0583	DNA-binding transcription factor activity
D0S46_RS03305	COG0626	cystathionine gamma-synthase activity
D0S46_RS03320	COG3121	Chaperone
D0S46_RS03335	COG3121	Chaperone
D0S46_RS03340	COG3121	Chaperone
D0S46_RS03345	COG3188	usher protein
D0S46_RS03370	COG1811	Na channel or pump
D0S46_RS03380	COG1982	Orn Lys Arg decarboxylase major
D0S46_RS03385	COG2211	Major facilitator Superfamily
D0S46_RS03400	COG1194	a g-specific adenine glycosylase
D0S46_RS03410	COG3171	Protein conserved in bacteria
D0S46_RS03420	COG4214	carbohydrate transport
D0S46_RS03435	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D0S46_RS03450	COG0762	integral membrane protein
D0S46_RS03455	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D0S46_RS03460	COG2805	Type II/IV secretion system protein
D0S46_RS03480	COG0189	ligase activity
D0S46_RS03485	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D0S46_RS03490	COG2356	endonuclease I
D0S46_RS03500	COG2814	Major facilitator Superfamily
D0S46_RS03535	COG0501	Belongs to the peptidase M48B family
D0S46_RS03540	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D0S46_RS03555	COG0191	fructose-bisphosphate aldolase activity
D0S46_RS03560	COG0668	transmembrane transport
D0S46_RS03570	COG2968	Membrane
D0S46_RS03585	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D0S46_RS03590	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D0S46_RS03610	COG0006	proline dipeptidase activity
D0S46_RS03615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D0S46_RS03620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D0S46_RS03640	COG1028	Short-chain dehydrogenase reductase Sdr
D0S46_RS03645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D0S46_RS03665	COG2723	6-phospho-beta-galactosidase activity
D0S46_RS03670	COG1737	Transcriptional regulator
D0S46_RS03680	COG1272	protein, Hemolysin III
D0S46_RS03690	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
D0S46_RS03700	COG0716	FMN binding
D0S46_RS03705	COG4974	Belongs to the 'phage' integrase family
D0S46_RS03715	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D0S46_RS03735	COG1811	Na channel or pump
D0S46_RS03745	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D0S46_RS03750	COG0583	DNA-binding transcription factor activity
D0S46_RS03755	COG4942	peptidase
D0S46_RS03765	COG2814	Major facilitator Superfamily
D0S46_RS03780	COG0667	Aldo Keto reductase
D0S46_RS03820	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D0S46_RS03825	COG1393	Belongs to the ArsC family
D0S46_RS03830	COG3104	oligopeptide transport
D0S46_RS03840	COG1538	Outer membrane efflux protein
D0S46_RS03845	COG1289	transmembrane transporter activity
D0S46_RS03860	COG3592	Divergent 4Fe-4S mono-cluster
D0S46_RS03865	COG2388	GCN5-related N-acetyl-transferase
D0S46_RS03875	COG3539	Fimbrial protein
D0S46_RS03880	COG3539	Fimbrial protein
D0S46_RS03885	COG3539	Fimbrial protein
D0S46_RS03890	COG3188	usher protein
D0S46_RS03895	COG3121	Chaperone
D0S46_RS03900	COG3539	Fimbrial protein
D0S46_RS03910	COG4974	Belongs to the 'phage' integrase family
D0S46_RS03915	COG0582	viral genome integration into host DNA
D0S46_RS03925	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
D0S46_RS03930	COG1846	Transcriptional regulator
D0S46_RS03935	COG0697	spore germination
D0S46_RS03985	COG0667	Aldo Keto reductase
D0S46_RS03990	COG0814	amino acid
D0S46_RS04005	COG0183	Belongs to the thiolase family
D0S46_RS04020	COG0823	Involved in the tonB-independent uptake of proteins
D0S46_RS04025	COG1028	Short-chain dehydrogenase reductase Sdr
D0S46_RS04030	COG2814	Major facilitator Superfamily
D0S46_RS04060	COG3842	ATPase activity
D0S46_RS04065	COG0395	ABC-type sugar transport system, permease component
D0S46_RS04070	COG1175	transmembrane transport
D0S46_RS04075	COG1917	Cupin 2, conserved barrel domain protein
D0S46_RS04080	COG1794	racemase activity, acting on amino acids and derivatives
D0S46_RS04085	COG0583	DNA-binding transcription factor activity
D0S46_RS04095	COG1609	Transcriptional regulator
D0S46_RS04100	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0S46_RS04105	COG2723	6-phospho-beta-galactosidase activity
D0S46_RS04110	COG2186	Transcriptional regulator
D0S46_RS04120	COG1609	Transcriptional regulator
D0S46_RS04145	COG0667	Aldo Keto reductase
D0S46_RS04155	COG0861	Integral membrane protein TerC family
D0S46_RS04190	COG2165	general secretion pathway protein
D0S46_RS04195	COG4795	General secretion pathway protein
D0S46_RS04205	COG4967	type IV pilus modification protein PilV
D0S46_RS04210	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
D0S46_RS04215	COG1025	Belongs to the peptidase M16 family
D0S46_RS04225	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D0S46_RS04235	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D0S46_RS04235	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D0S46_RS04240	COG0860	N-Acetylmuramoyl-L-alanine amidase
D0S46_RS04245	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D0S46_RS04275	COG4656	Part of a membrane complex involved in electron transport
D0S46_RS04280	COG1012	belongs to the aldehyde dehydrogenase family
D0S46_RS04280	COG1454	alcohol dehydrogenase
D0S46_RS04510	COG2885	chlorophyll binding
D0S46_RS04545	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D0S46_RS04550	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D0S46_RS04555	COG2166	iron-sulfur cluster assembly
D0S46_RS04560	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D0S46_RS04570	COG0583	DNA-binding transcription factor activity
D0S46_RS04575	COG2363	Small membrane protein
D0S46_RS04585	COG1349	DNA-binding transcription factor activity
D0S46_RS04605	COG0738	Major facilitator superfamily
D0S46_RS04610	COG0235	Class ii aldolase
D0S46_RS04615	COG1454	alcohol dehydrogenase
D0S46_RS04630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D0S46_RS04645	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D0S46_RS04650	COG2011	ABC-type metal ion transport system permease component
D0S46_RS04655	COG1464	Belongs to the NlpA lipoprotein family
D0S46_RS04665	COG0477	Major facilitator Superfamily
D0S46_RS04675	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D0S46_RS04680	COG1760	l-serine dehydratase
D0S46_RS04685	COG0814	amino acid
D0S46_RS04690	COG1611	Belongs to the LOG family
D0S46_RS04705	COG3098	single-species biofilm formation
D0S46_RS04710	COG0564	pseudouridine synthase activity
D0S46_RS04715	COG0716	FMN binding
D0S46_RS04720	COG2271	Major facilitator Superfamily
D0S46_RS04725	COG4948	Mandelate Racemase Muconate Lactonizing
D0S46_RS04730	COG4948	Mandelate Racemase Muconate Lactonizing
D0S46_RS04735	COG1929	Belongs to the glycerate kinase type-1 family
D0S46_RS04745	COG3437	response regulator, receiver
D0S46_RS04745	COG4999	Histidine kinase
D0S46_RS04745	COG3850	Histidine kinase
D0S46_RS04745	COG2205	protein histidine kinase activity
D0S46_RS04755	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D0S46_RS04760	COG3956	TIGRFAM MazG family protein
D0S46_RS04780	COG0602	queuosine metabolic process
D0S46_RS04785	COG0720	synthase
D0S46_RS04805	COG2234	aminopeptidase activity
D0S46_RS04865	COG4942	peptidase
D0S46_RS04865	COG1388	LysM domain
D0S46_RS04870	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D0S46_RS04895	COG0163	prenyltransferase activity
D0S46_RS04900	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D0S46_RS04945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0S46_RS04950	COG4558	Periplasmic binding protein
D0S46_RS04955	COG3720	iron ion transport
D0S46_RS04975	COG0679	Auxin Efflux Carrier
D0S46_RS04990	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D0S46_RS04995	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D0S46_RS05000	COG1121	(ABC) transporter
D0S46_RS05005	COG0803	Belongs to the bacterial solute-binding protein 9 family
D0S46_RS05010	COG1609	Transcriptional regulator
D0S46_RS05015	COG1940	carbohydrate kinase activity
D0S46_RS05020	COG1447	Phosphotransferase system cellobiose-specific component IIA
D0S46_RS05025	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0S46_RS05030	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0S46_RS05035	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0S46_RS05045	COG4580	involved in the transport of maltose and maltodextrins
D0S46_RS05055	COG2723	6-phospho-beta-galactosidase activity
D0S46_RS05065	COG0309	Hydrogenase expression formation protein (HypE)
D0S46_RS05070	COG0409	Hydrogenase expression formation protein
D0S46_RS05075	COG0298	carbon dioxide binding
D0S46_RS05080	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D0S46_RS05100	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D0S46_RS05105	COG0651	ATP synthesis coupled electron transport
D0S46_RS05110	COG0650	Formate hydrogenlyase subunit 4
D0S46_RS05115	COG3261	NADH dehydrogenase
D0S46_RS05115	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
D0S46_RS05120	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D0S46_RS05125	COG3260	NADH ubiquinone oxidoreductase 20
D0S46_RS05135	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D0S46_RS05145	COG2723	6-phospho-beta-galactosidase activity
D0S46_RS05150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0S46_RS05150	COG1263	PTS System
D0S46_RS05155	COG1609	Transcriptional regulator
D0S46_RS05160	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D0S46_RS05165	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
D0S46_RS05170	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
D0S46_RS05200	COG1349	DNA-binding transcription factor activity
D0S46_RS05205	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0S46_RS05210	COG1028	Short-chain dehydrogenase reductase Sdr
D0S46_RS05220	COG3732	PTS system glucitol sorbitol-specific
D0S46_RS05225	COG3730	PTS system glucitol sorbitol-specific
D0S46_RS05230	COG2951	lytic endotransglycosylase activity
D0S46_RS05240	COG1121	(ABC) transporter
D0S46_RS05245	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D0S46_RS05250	COG0803	Belongs to the bacterial solute-binding protein 9 family
D0S46_RS05255	COG1546	Belongs to the CinA family
D0S46_RS05275	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
D0S46_RS05305	COG2823	Periplasmic or secreted lipoprotein
D0S46_RS05310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0S46_RS05315	COG1238	metal cluster binding
D0S46_RS05335	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D0S46_RS05340	COG2814	Major facilitator Superfamily
D0S46_RS05345	COG1566	PFAM secretion protein HlyD family protein
D0S46_RS05350	COG1846	Transcriptional regulator
D0S46_RS05360	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
D0S46_RS05370	COG4176	ABC-type proline glycine betaine transport system permease component
D0S46_RS05385	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D0S46_RS05395	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D0S46_RS05400	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D0S46_RS05405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0S46_RS05410	COG4575	ribosome binding
D0S46_RS05435	COG2916	Histone family protein nucleoid-structuring protein H-NS
D0S46_RS05450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D0S46_RS05455	COG0640	Transcriptional regulator
D0S46_RS05465	COG0583	DNA-binding transcription factor activity
D0S46_RS05470	COG3284	Transcriptional regulator
D0S46_RS05475	COG1012	belongs to the aldehyde dehydrogenase family
D0S46_RS05480	COG3539	Fimbrial protein
D0S46_RS05485	COG3121	Chaperone
D0S46_RS05505	COG3188	usher protein
D0S46_RS05515	COG3539	Fimbrial protein
D0S46_RS05520	COG2197	response regulator
D0S46_RS05535	COG1028	Short-chain dehydrogenase reductase Sdr
D0S46_RS05545	COG0235	Class ii aldolase
D0S46_RS05555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0S46_RS05590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0S46_RS05595	COG2207	Transcriptional regulator
D0S46_RS05595	COG3708	Transcriptional regulator
D0S46_RS05625	COG2867	negative regulation of translational initiation
D0S46_RS05640	COG0497	DNA recombination
D0S46_RS05660	COG4536	flavin adenine dinucleotide binding
D0S46_RS05665	COG4137	Cytochrome C assembly protein
D0S46_RS05670	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D0S46_RS05705	COG2885	chlorophyll binding
D0S46_RS05710	COG2199	diguanylate cyclase activity
D0S46_RS05720	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D0S46_RS05725	COG1605	Chorismate mutase
D0S46_RS05725	COG0287	Prephenate dehydrogenase
D0S46_RS05735	COG0077	Prephenate dehydratase
D0S46_RS05735	COG1605	Chorismate mutase
D0S46_RS05745	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D0S46_RS05750	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0S46_RS05765	COG0542	response to heat
D0S46_RS05790	COG0477	Major facilitator Superfamily
D0S46_RS05795	COG5544	Lipoprotein
D0S46_RS05800	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D0S46_RS05815	COG3118	belongs to the thioredoxin family
D0S46_RS05820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D0S46_RS05835	COG0513	Belongs to the DEAD box helicase family
D0S46_RS05845	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D0S46_RS05855	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
D0S46_RS05860	COG3026	antisigma factor binding
D0S46_RS05865	COG3086	response to oxidative stress
D0S46_RS05905	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D0S46_RS05960	COG1484	DNA-dependent DNA replication
D0S46_RS06015	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
D0S46_RS06020	COG0484	heat shock protein binding
D0S46_RS06040	COG3179	chitinase
D0S46_RS06075	COG5484	DNA packaging
D0S46_RS06075	COG3728	DNA packaging
D0S46_RS06165	COG1196	nuclear chromosome segregation
D0S46_RS06225	COG0681	Belongs to the peptidase S26 family
D0S46_RS06245	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D0S46_RS06255	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D0S46_RS06260	COG1737	Transcriptional regulator
D0S46_RS06265	COG0560	Phosphoserine phosphatase
D0S46_RS06280	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D0S46_RS06280	COG0047	phosphoribosylformylglycinamidine synthase activity
D0S46_RS06290	COG2205	protein histidine kinase activity
D0S46_RS06295	COG3170	Tfp pilus assembly protein FimV
D0S46_RS06300	COG2204	response regulator
D0S46_RS06305	COG0347	Belongs to the P(II) protein family
D0S46_RS06310	COG1017	nitric oxide dioxygenase activity
D0S46_RS06310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D0S46_RS06325	COG2259	Doxx family
D0S46_RS06330	COG1940	carbohydrate kinase activity
D0S46_RS06335	COG0457	Tetratricopeptide repeat
D0S46_RS06340	COG0477	Major facilitator Superfamily
D0S46_RS06340	COG2814	Major facilitator Superfamily
D0S46_RS06345	COG2017	converts alpha-aldose to the beta-anomer
D0S46_RS06350	COG2814	Major facilitator Superfamily
D0S46_RS06355	COG3711	transcriptional antiterminator
D0S46_RS06360	COG3683	transport system, periplasmic component
D0S46_RS06365	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
D0S46_RS06395	COG0822	iron-sulfur transferase activity
D0S46_RS06415	COG0633	Ferredoxin
D0S46_RS06420	COG2975	iron-sulfur cluster assembly
D0S46_RS06440	COG2897	thiosulfate sulfurtransferase activity
D0S46_RS06445	COG2373	Large extracellular alpha-helical protein
D0S46_RS06450	COG4953	penicillin-binding protein 1C
D0S46_RS06485	COG2976	Protein conserved in bacteria
D0S46_RS06605	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D0S46_RS06605	COG0758	DNA mediated transformation
D0S46_RS06630	COG1645	bacterial-type flagellum-dependent swarming motility
D0S46_RS06640	COG0517	IMP dehydrogenase activity
D0S46_RS06640	COG0516	GMP reductase activity
D0S46_RS06650	COG3119	arylsulfatase activity
D0S46_RS06655	COG0641	radical SAM
D0S46_RS06675	COG2200	EAL domain
D0S46_RS06690	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D0S46_RS06705	COG2723	6-phospho-beta-galactosidase activity
D0S46_RS06715	COG2233	PERMEase
D0S46_RS06730	COG1393	Belongs to the ArsC family
D0S46_RS06735	COG4783	chaperone-mediated protein folding
D0S46_RS06740	COG0628	permease
D0S46_RS06745	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D0S46_RS06750	COG2716	regulation of RNA biosynthetic process
D0S46_RS06760	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
D0S46_RS06770	COG2321	neutral zinc metallopeptidase
D0S46_RS06775	COG1444	tRNA N-acetyltransferase activity
D0S46_RS06780	COG0400	carboxylic ester hydrolase activity
D0S46_RS06795	COG1393	Belongs to the ArsC family
D0S46_RS06805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0S46_RS06815	COG0493	'glutamate synthase
D0S46_RS06815	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D0S46_RS06825	COG5342	invasion associated locus B
D0S46_RS06830	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D0S46_RS06835	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D0S46_RS06845	COG4810	utilization protein
D0S46_RS06935	COG0860	N-Acetylmuramoyl-L-alanine amidase
D0S46_RS06955	COG2837	iron assimilation
D0S46_RS06965	COG4150	thiosulfate binding
D0S46_RS06970	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
D0S46_RS06975	COG4208	sulfate ABC transporter
D0S46_RS06980	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D0S46_RS06990	COG4319	ketosteroid isomerase
D0S46_RS07025	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D0S46_RS07045	COG3530	Putative quorum-sensing-regulated virulence factor
D0S46_RS07050	COG0385	Bile acid
D0S46_RS07055	COG0583	DNA-binding transcription factor activity
D0S46_RS07090	COG3415	Transposase
D0S46_RS07095	COG3415	Transposase
D0S46_RS07105	COG2200	EAL domain
D0S46_RS07105	COG2199	diguanylate cyclase activity
D0S46_RS07110	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D0S46_RS07125	COG0667	Aldo Keto reductase
D0S46_RS07130	COG3961	Belongs to the TPP enzyme family
D0S46_RS07145	COG3279	Response regulator of the LytR AlgR family
D0S46_RS07150	COG3275	phosphorelay sensor kinase activity
D0S46_RS07160	COG0436	Aminotransferase
D0S46_RS07170	COG2807	transmembrane transport
D0S46_RS07175	COG0590	tRNA wobble adenosine to inosine editing
D0S46_RS07180	COG0583	DNA-binding transcription factor activity
D0S46_RS07200	COG2116	formate transmembrane transporter activity
D0S46_RS07205	COG2853	Lipoprotein
D0S46_RS07220	COG3691	Protein conserved in bacteria
D0S46_RS07235	COG2062	phosphohistidine phosphatase, SixA
D0S46_RS07260	COG0730	response to heat
D0S46_RS07265	COG3101	peptidyl-lysine hydroxylation
D0S46_RS07280	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D0S46_RS07300	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D0S46_RS07310	COG0586	Pfam SNARE associated Golgi protein
D0S46_RS07320	COG0285	dihydrofolate synthase activity
D0S46_RS07325	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
D0S46_RS07330	COG1286	toxin biosynthetic process
D0S46_RS07335	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D0S46_RS07340	COG0163	prenyltransferase activity
D0S46_RS07360	COG4160	amino acid transport
D0S46_RS07365	COG4598	ABC transporter
D0S46_RS07375	COG1090	epimerase
D0S46_RS07380	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D0S46_RS07385	COG0625	glutathione transferase activity
D0S46_RS07390	COG0625	glutathione transferase activity
D0S46_RS07395	COG0622	Phosphoesterase
D0S46_RS07400	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D0S46_RS07405	COG0280	phosphate acetyltransferase
D0S46_RS07405	COG0857	belongs to the CobB CobQ family
D0S46_RS07425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0S46_RS07430	COG0471	metal ion transport
D0S46_RS07430	COG0490	domain, Protein
D0S46_RS07440	COG0436	Aminotransferase
D0S46_RS07445	COG0583	DNA-binding transcription factor activity
D0S46_RS07500	COG0839	Belongs to the complex I subunit 6 family
D0S46_RS07510	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D0S46_RS07515	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D0S46_RS07530	COG2153	protein acetylation
D0S46_RS07535	COG1169	isochorismate synthase
D0S46_RS07560	COG0318	PFAM AMP-dependent synthetase and ligase
D0S46_RS07570	COG5464	transposase or invertase
D0S46_RS07590	COG1414	Transcriptional regulator
D0S46_RS07600	COG2271	Major facilitator Superfamily
D0S46_RS07610	COG0247	lactate metabolic process
D0S46_RS07620	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D0S46_RS07625	COG2271	Major facilitator Superfamily
D0S46_RS07640	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D0S46_RS07670	COG2205	protein histidine kinase activity
D0S46_RS07670	COG0784	Response regulator, receiver
D0S46_RS07680	COG2198	Histidine kinase
D0S46_RS07680	COG0642	Histidine kinase
D0S46_RS07695	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D0S46_RS07695	COG2169	Transcriptional regulator
D0S46_RS07700	COG3145	DNA-N1-methyladenine dioxygenase activity
D0S46_RS07705	COG4615	Cyclic peptide transporter
D0S46_RS07710	COG2239	Acts as a magnesium transporter
D0S46_RS07715	COG0659	secondary active sulfate transmembrane transporter activity
D0S46_RS07730	COG0628	permease
D0S46_RS07755	COG1349	DNA-binding transcription factor activity
D0S46_RS07760	COG0494	nUDIX hydrolase
D0S46_RS07780	COG1061	Type III restriction enzyme res subunit
D0S46_RS07785	COG1187	pseudouridine synthase activity
D0S46_RS07790	COG2814	Major facilitator Superfamily
D0S46_RS07800	COG4172	Belongs to the ABC transporter superfamily
D0S46_RS07805	COG4239	(ABC) transporter, permease
D0S46_RS07810	COG4174	ABC transporter (Permease)
D0S46_RS07815	COG4166	transmembrane transport
D0S46_RS07820	COG2200	EAL domain
D0S46_RS07825	COG0791	NLP P60 protein
D0S46_RS07830	COG0671	phosphoesterase, PA-phosphatase related
D0S46_RS07835	COG0523	cobalamin synthesis protein
D0S46_RS07840	COG0246	Mannitol dehydrogenase
D0S46_RS07845	COG1312	Catalyzes the dehydration of D-mannonate
D0S46_RS07870	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0S46_RS07870	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0S46_RS07875	COG1105	Belongs to the carbohydrate kinase PfkB family
D0S46_RS07880	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0S46_RS07880	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0S46_RS07880	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
D0S46_RS07890	COG2855	membrane
D0S46_RS07900	COG0583	DNA-binding transcription factor activity
D0S46_RS07905	COG0833	amino acid
D0S46_RS07915	COG4771	TonB-dependent receptor
D0S46_RS07930	COG2311	Membrane
D0S46_RS07945	COG1129	ABC transporter
D0S46_RS07955	COG2949	membrane
D0S46_RS07965	COG1346	cytolysis
D0S46_RS07975	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D0S46_RS07980	COG3659	wide pore channel activity
D0S46_RS07995	COG2723	6-phospho-beta-galactosidase activity
D0S46_RS08005	COG1538	Outer membrane efflux protein
D0S46_RS08010	COG0586	Pfam SNARE associated Golgi protein
D0S46_RS08020	COG1686	Belongs to the peptidase S11 family
D0S46_RS08030	COG0277	FAD linked oxidase domain protein
D0S46_RS08035	COG1472	Belongs to the glycosyl hydrolase 3 family
D0S46_RS08040	COG1732	Glycine betaine
D0S46_RS08045	COG1174	glycine betaine transport
D0S46_RS08050	COG1125	glycine betaine transport
D0S46_RS08055	COG1174	glycine betaine transport
D0S46_RS08065	COG3275	phosphorelay sensor kinase activity
D0S46_RS08075	COG4807	Protein conserved in bacteria
D0S46_RS08095	COG5455	response to cobalt ion
D0S46_RS08100	COG0583	DNA-binding transcription factor activity
D0S46_RS08105	COG2252	PERMEase
D0S46_RS08115	COG0583	DNA-binding transcription factor activity
D0S46_RS08130	COG0351	phosphomethylpyrimidine kinase
D0S46_RS08135	COG1830	Aldolase
D0S46_RS08170	COG1070	Carbohydrate kinase
D0S46_RS08180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0S46_RS08185	COG4948	Mandelate Racemase Muconate Lactonizing
D0S46_RS08190	COG0747	negative chemotaxis
D0S46_RS08195	COG0601	transmembrane transport
D0S46_RS08205	COG0444	Belongs to the ABC transporter superfamily
D0S46_RS08210	COG4608	Belongs to the ABC transporter superfamily
D0S46_RS08225	COG0745	RESPONSE REGULATOR receiver
D0S46_RS08230	COG2205	protein histidine kinase activity
D0S46_RS08255	COG1301	dicarboxylic acid transport
D0S46_RS08270	COG5002	protein histidine kinase activity
D0S46_RS08275	COG0443	Heat shock 70 kDa protein
D0S46_RS08285	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
D0S46_RS08300	COG2982	Protein involved in outer membrane biogenesis
D0S46_RS08305	COG1253	flavin adenine dinucleotide binding
D0S46_RS08360	COG1216	Glycosyl transferase, family 2
D0S46_RS08360	COG1442	glycosyl transferase family 8
D0S46_RS08370	COG0438	transferase activity, transferring glycosyl groups
D0S46_RS08400	COG1088	dTDP-glucose 4,6-dehydratase activity
D0S46_RS08470	COG0438	transferase activity, transferring glycosyl groups
D0S46_RS08475	COG1215	transferase activity, transferring glycosyl groups
D0S46_RS08495	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D0S46_RS08525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D0S46_RS08530	COG0583	DNA-binding transcription factor activity
D0S46_RS08540	COG0531	amino acid
D0S46_RS08545	COG0640	Transcriptional regulator
D0S46_RS08550	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D0S46_RS08555	COG2925	Exonuclease
D0S46_RS08570	COG1289	transmembrane transporter activity
D0S46_RS08590	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D0S46_RS08600	COG1942	4-Oxalocrotonate Tautomerase
D0S46_RS08605	COG0583	DNA-binding transcription factor activity
D0S46_RS08610	COG0095	Lipoate-protein ligase
D0S46_RS08615	COG0477	Major facilitator Superfamily
D0S46_RS08630	COG5001	Diguanylate cyclase
D0S46_RS08630	COG3300	MHYT domain
D0S46_RS08640	COG3615	Tellurite resistance protein tehB
D0S46_RS08665	COG3706	GGDEF domain
D0S46_RS08770	COG3504	Conjugal transfer protein
D0S46_RS08845	COG4771	TonB-dependent receptor
D0S46_RS08850	COG1021	2,3-dihydroxybenzoate-AMP ligase
D0S46_RS08870	COG2226	methyltransferase
D0S46_RS08870	COG3433	isochorismatase activity
D0S46_RS08870	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D0S46_RS08885	COG1132	(ABC) transporter
D0S46_RS08890	COG2814	Major facilitator Superfamily
D0S46_RS08895	COG1169	isochorismate synthase
D0S46_RS08900	COG0582	viral genome integration into host DNA
D0S46_RS08910	COG0534	Mate efflux family protein
D0S46_RS08920	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D0S46_RS08940	COG0604	alcohol dehydrogenase
D0S46_RS08945	COG1309	transcriptional regulator
D0S46_RS08950	COG0025	NhaP-type Na H and K H
D0S46_RS09000	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D0S46_RS09015	COG1418	mRNA catabolic process
D0S46_RS09020	COG0270	DNA (cytosine-5-)-methyltransferase activity
D0S46_RS09025	COG3727	T/G mismatch-specific endonuclease activity
D0S46_RS09030	COG0697	spore germination
D0S46_RS09035	COG2354	Protein conserved in bacteria
D0S46_RS09065	COG0366	Alpha amylase catalytic
D0S46_RS09090	COG2197	response regulator
D0S46_RS09100	COG2197	response regulator
D0S46_RS09135	COG3318	Belongs to the UPF0149 family
D0S46_RS09135	COG3012	SEC-C Motif Domain Protein
D0S46_RS09140	COG0814	amino acid
D0S46_RS09150	COG1528	Iron-storage protein
D0S46_RS09165	COG0477	Major facilitator Superfamily
D0S46_RS09175	COG2211	Major facilitator Superfamily
D0S46_RS09185	COG1528	Iron-storage protein
D0S46_RS09195	COG1879	ABC-type sugar transport system periplasmic component
D0S46_RS09205	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0S46_RS09230	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D0S46_RS09240	COG3102	Protein conserved in bacteria
D0S46_RS09260	COG3788	relative of glutathione S-transferase, MAPEG superfamily
D0S46_RS09265	COG1801	Protein of unknown function DUF72
D0S46_RS09270	COG0582	viral genome integration into host DNA
D0S46_RS09435	COG3772	lysozyme
D0S46_RS09595	COG3344	reverse transcriptase
D0S46_RS09610	COG1335	isochorismatase
D0S46_RS09620	COG0494	nUDIX hydrolase
D0S46_RS09645	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D0S46_RS09655	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
D0S46_RS09660	COG0739	heme binding
D0S46_RS09665	COG1560	Kdo2-lipid A biosynthetic process
D0S46_RS09675	COG1737	Transcriptional regulator
D0S46_RS09690	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D0S46_RS09695	COG0129	dihydroxy-acid dehydratase activity
D0S46_RS09700	COG0800	Aldolase
D0S46_RS09710	COG3141	response to X-ray
D0S46_RS09715	COG2979	Protein of unknown function (DUF533)
D0S46_RS09720	COG1770	oligopeptidase
D0S46_RS09725	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D0S46_RS09735	COG2372	response to copper ion
D0S46_RS09740	COG1276	copper resistance
D0S46_RS09755	COG2990	Protein conserved in bacteria
D0S46_RS09780	COG3008	intermembrane lipid transfer
D0S46_RS09785	COG2995	paraquat-inducible protein a
D0S46_RS09790	COG1956	GAF domain-containing protein
D0S46_RS09820	COG1414	Transcriptional regulator
D0S46_RS09860	COG0768	penicillin binding
D0S46_RS09865	COG2226	methyltransferase
D0S46_RS09880	COG3716	PTS system mannose fructose sorbose family IID component
D0S46_RS09885	COG3715	PTS system
D0S46_RS09890	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0S46_RS09890	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0S46_RS09895	COG1253	flavin adenine dinucleotide binding
D0S46_RS09900	COG2200	EAL domain
D0S46_RS09905	COG1760	l-serine dehydratase
D0S46_RS09925	COG0251	oxidation-reduction process
D0S46_RS09930	COG1199	ATP-dependent helicase activity
D0S46_RS09950	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D0S46_RS09960	COG2894	cell division
D0S46_RS09975	COG0179	Fumarylacetoacetate (FAA) hydrolase
D0S46_RS10005	COG2719	SpoVR family
D0S46_RS10025	COG1619	proteins homologs of microcin C7 resistance protein MccF
D0S46_RS10035	COG4774	siderophore transport
D0S46_RS10050	COG2308	Evidence 4 Homologs of previously reported genes of
D0S46_RS10100	COG0583	DNA-binding transcription factor activity
D0S46_RS10105	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D0S46_RS10120	COG1882	Formate acetyltransferase
D0S46_RS10150	COG0583	DNA-binding transcription factor activity
D0S46_RS10180	COG0583	DNA-binding transcription factor activity
D0S46_RS10195	COG3122	Protein conserved in bacteria
D0S46_RS10225	COG2885	chlorophyll binding
D0S46_RS10230	COG3501	Rhs element vgr protein
D0S46_RS10245	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D0S46_RS10320	COG0012	GTP binding
D0S46_RS10340	COG0659	secondary active sulfate transmembrane transporter activity
D0S46_RS10375	COG2890	protein-(glutamine-N5) methyltransferase activity
D0S46_RS10395	COG0387	Pfam Sodium calcium exchanger
D0S46_RS10400	COG4572	Cation transport regulator
D0S46_RS10405	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
D0S46_RS10415	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
D0S46_RS10420	COG3707	response regulator
D0S46_RS10425	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D0S46_RS10435	COG1116	anion transmembrane transporter activity
D0S46_RS10440	COG2146	nitrite reductase [NAD(P)H] activity
D0S46_RS10440	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D0S46_RS10445	COG0243	molybdopterin cofactor binding
D0S46_RS10450	COG4932	domain protein
D0S46_RS10455	COG2197	response regulator
D0S46_RS10460	COG3850	Histidine kinase
D0S46_RS10465	COG2223	nitrite transmembrane transporter activity
D0S46_RS10470	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
D0S46_RS10475	COG1140	nitrate reductase beta subunit
D0S46_RS10480	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
D0S46_RS10485	COG2181	nitrate reductase activity
D0S46_RS10495	COG1522	sequence-specific DNA binding
D0S46_RS10540	COG0788	formyltetrahydrofolate deformylase activity
D0S46_RS10550	COG1752	Esterase of the alpha-beta hydrolase superfamily
D0S46_RS10555	COG0745	RESPONSE REGULATOR receiver
D0S46_RS10560	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D0S46_RS10565	COG2916	Histone family protein nucleoid-structuring protein H-NS
D0S46_RS10570	COG1435	thymidine kinase activity
D0S46_RS10575	COG1012	belongs to the aldehyde dehydrogenase family
D0S46_RS10575	COG1454	alcohol dehydrogenase
D0S46_RS10585	COG2095	MarC family integral membrane protein
D0S46_RS10590	COG4166	transmembrane transport
D0S46_RS10595	COG0601	transmembrane transport
D0S46_RS10600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0S46_RS10605	COG0444	Belongs to the ABC transporter superfamily
D0S46_RS10615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D0S46_RS10635	COG2353	YceI-like domain
D0S46_RS10640	COG2350	Protein conserved in bacteria
D0S46_RS10650	COG3001	Fructosamine kinase
D0S46_RS10660	COG1105	Belongs to the carbohydrate kinase PfkB family
D0S46_RS10665	COG3137	Salt-induced outer membrane protein
D0S46_RS10705	COG0072	phenylalanine-tRNA ligase activity
D0S46_RS10705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D0S46_RS10725	COG0583	DNA-binding transcription factor activity
D0S46_RS10745	COG0386	Belongs to the glutathione peroxidase family
D0S46_RS10755	COG0791	NLP P60 protein
D0S46_RS10765	COG4256	Hemin uptake protein
D0S46_RS10770	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D0S46_RS10780	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D0S46_RS10780	COG0574	Belongs to the PEP-utilizing enzyme family
D0S46_RS10790	COG0628	permease
D0S46_RS10795	COG0247	lactate metabolic process
D0S46_RS10795	COG0277	FAD linked oxidase domain protein
D0S46_RS10800	COG2050	protein possibly involved in aromatic compounds catabolism
D0S46_RS10805	COG2261	transglycosylase associated protein
D0S46_RS10835	COG1120	ATPase activity
D0S46_RS10840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0S46_RS10850	COG0583	DNA-binding transcription factor activity
D0S46_RS10875	COG1304	FMN binding
D0S46_RS10880	COG1309	transcriptional regulator
D0S46_RS10895	COG0316	Belongs to the HesB IscA family
D0S46_RS10900	COG0719	Fe-S assembly protein
D0S46_RS10905	COG0396	ATPase activity
D0S46_RS10910	COG0719	Fe-S assembly protein
D0S46_RS10925	COG1376	ErfK ybiS ycfS ynhG family protein
D0S46_RS10950	COG1309	transcriptional regulator
D0S46_RS10960	COG2271	Major facilitator Superfamily
D0S46_RS10965	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D0S46_RS10990	COG1414	Transcriptional regulator
D0S46_RS11025	COG2814	Major facilitator Superfamily
D0S46_RS11045	COG0583	DNA-binding transcription factor activity
D0S46_RS11050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D0S46_RS11070	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D0S46_RS11075	COG1116	anion transmembrane transporter activity
D0S46_RS11080	COG4774	siderophore transport
D0S46_RS11085	COG1120	ATPase activity
D0S46_RS11090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0S46_RS11095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0S46_RS11115	COG0765	amino acid transport
D0S46_RS11120	COG1126	abc transporter atp-binding protein
D0S46_RS11155	COG3383	formate dehydrogenase (NAD+) activity
D0S46_RS11160	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D0S46_RS11175	COG1175	transmembrane transport
D0S46_RS11210	COG1857	crispr-associated protein
D0S46_RS11220	COG1518	maintenance of DNA repeat elements
D0S46_RS11225	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D0S46_RS11235	COG3157	Type VI secretion system effector, Hcp
D0S46_RS11265	COG4133	protoheme IX ABC transporter activity
D0S46_RS11270	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D0S46_RS11275	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D0S46_RS11290	COG1138	Cytochrome C-type biogenesis protein
D0S46_RS11295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D0S46_RS11300	COG3088	subunit of a heme lyase
D0S46_RS11300	COG4235	cytochrome complex assembly
D0S46_RS11350	COG1028	Short-chain dehydrogenase reductase Sdr
D0S46_RS11355	COG2610	gluconate transmembrane transporter activity
D0S46_RS11360	COG1250	3-hydroxyacyl-CoA dehydrogenase
D0S46_RS11370	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D0S46_RS11380	COG0583	DNA-binding transcription factor activity
D0S46_RS11400	COG0277	FAD linked oxidase domain protein
D0S46_RS11405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D0S46_RS11430	COG0402	S-adenosylhomocysteine deaminase activity
D0S46_RS11555	COG2814	Major facilitator Superfamily
D0S46_RS11560	COG1082	Xylose isomerase domain protein TIM barrel
D0S46_RS11570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0S46_RS11600	COG4608	Belongs to the ABC transporter superfamily
D0S46_RS11605	COG0444	Belongs to the ABC transporter superfamily
D0S46_RS11630	COG0346	lactoylglutathione lyase activity
D0S46_RS11635	COG1349	DNA-binding transcription factor activity
D0S46_RS11665	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D0S46_RS11685	COG0300	oxidoreductase activity
D0S46_RS11730	COG0307	riboflavin synthase, alpha
D0S46_RS11735	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D0S46_RS11740	COG2814	Major facilitator Superfamily
D0S46_RS11745	COG0583	DNA-binding transcription factor activity
D0S46_RS11760	COG2814	Major facilitator Superfamily
D0S46_RS11775	COG0791	NLP P60 protein
D0S46_RS11780	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D0S46_RS11790	COG0346	lactoylglutathione lyase activity
D0S46_RS11795	COG1902	pentaerythritol trinitrate reductase activity
D0S46_RS11800	COG1309	transcriptional regulator
D0S46_RS11805	COG3313	Fe-S protein
D0S46_RS11810	COG4989	oxidoreductase activity
D0S46_RS11815	COG2032	superoxide dismutase activity
D0S46_RS11820	COG1289	transmembrane transporter activity
D0S46_RS11825	COG1566	PFAM secretion protein HlyD family protein
D0S46_RS11855	COG3895	Periplasmic Protein
D0S46_RS11870	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
D0S46_RS11875	COG0625	glutathione transferase activity
D0S46_RS11890	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D0S46_RS11900	COG4659	FMN binding
D0S46_RS11935	COG2723	6-phospho-beta-galactosidase activity
D0S46_RS11945	COG0673	inositol 2-dehydrogenase activity
D0S46_RS11955	COG2814	Major facilitator Superfamily
D0S46_RS11975	COG3038	cytochrome b561
D0S46_RS11995	COG0583	DNA-binding transcription factor activity
D0S46_RS12000	COG3485	protocatechuate 3,4-dioxygenase
D0S46_RS12005	COG3485	protocatechuate 3,4-dioxygenase
D0S46_RS12010	COG5383	Protein conserved in bacteria
D0S46_RS12015	COG2272	Belongs to the type-B carboxylesterase lipase family
D0S46_RS12030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0S46_RS12035	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D0S46_RS12040	COG1275	C4-dicarboxylate transporter malic acid transport protein
D0S46_RS12045	COG0500	methyltransferase
D0S46_RS12055	COG0697	spore germination
D0S46_RS12060	COG2207	Transcriptional regulator
D0S46_RS12060	COG3708	Transcriptional regulator
D0S46_RS12065	COG3135	benzoate transporter
D0S46_RS12070	COG1396	sequence-specific DNA binding
D0S46_RS12080	COG0826	peptidase U32
D0S46_RS12100	COG1294	oxidase, subunit
D0S46_RS12105	COG1271	oxidase subunit
D0S46_RS12110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0S46_RS12115	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D0S46_RS12120	COG3842	ATPase activity
D0S46_RS12125	COG1176	ABC-type spermidine putrescine transport system, permease component I
D0S46_RS12130	COG1177	transmembrane transport
D0S46_RS12135	COG1012	belongs to the aldehyde dehydrogenase family
D0S46_RS12165	COG1012	belongs to the aldehyde dehydrogenase family
D0S46_RS12170	COG0747	negative chemotaxis
D0S46_RS12180	COG3238	Protein conserved in bacteria
D0S46_RS12185	COG1247	-acetyltransferase
D0S46_RS12195	COG2130	NADP-dependent
D0S46_RS12210	COG3691	Protein conserved in bacteria
D0S46_RS12215	COG1228	amidohydrolase
D0S46_RS12220	COG4772	TonB-dependent receptor
D0S46_RS12245	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D0S46_RS12250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D0S46_RS12255	COG1473	amidohydrolase
D0S46_RS12260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D0S46_RS12280	COG1126	abc transporter atp-binding protein
D0S46_RS12290	COG0625	glutathione transferase activity
D0S46_RS12320	COG2211	Major facilitator Superfamily
D0S46_RS12335	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D0S46_RS12340	COG3842	ATPase activity
D0S46_RS12345	COG1840	ABC-type Fe3 transport system, periplasmic component
D0S46_RS12350	COG1178	ABC-type Fe3 transport system permease component
D0S46_RS12355	COG2162	N-hydroxyarylamine O-acetyltransferase activity
D0S46_RS12360	COG2181	nitrate reductase activity
D0S46_RS12365	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
D0S46_RS12370	COG1140	nitrate reductase beta subunit
D0S46_RS12375	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
D0S46_RS12395	COG1414	Transcriptional regulator
D0S46_RS12400	COG4948	Mandelate Racemase Muconate Lactonizing
D0S46_RS12405	COG4829	muconolactone delta-isomerase
D0S46_RS12410	COG3485	protocatechuate 3,4-dioxygenase
D0S46_RS12420	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
D0S46_RS12450	COG0437	4 iron, 4 sulfur cluster binding
D0S46_RS12455	COG2864	formate dehydrogenase
D0S46_RS12470	COG2326	polyphosphate kinase activity
D0S46_RS12480	COG2814	Major facilitator Superfamily
D0S46_RS12490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D0S46_RS12510	COG0747	negative chemotaxis
D0S46_RS12515	COG1064	alcohol dehydrogenase
D0S46_RS12530	COG0488	(ABC) transporter
D0S46_RS12565	COG1028	Short-chain dehydrogenase reductase Sdr
D0S46_RS12570	COG3729	General stress protein
D0S46_RS12590	COG3685	Protein conserved in bacteria
D0S46_RS12600	COG0366	Alpha amylase catalytic
D0S46_RS12610	COG2323	membrane
D0S46_RS12620	COG3111	PFAM Bacterial OB fold (BOF) protein
D0S46_RS12625	COG1764	response to oxidative stress
D0S46_RS12650	COG3781	membrane
D0S46_RS12655	COG0243	molybdopterin cofactor binding
D0S46_RS12660	COG0583	DNA-binding transcription factor activity
D0S46_RS12665	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0S46_RS12690	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0S46_RS12695	COG1447	Phosphotransferase system cellobiose-specific component IIA
D0S46_RS12700	COG2814	Major facilitator Superfamily
D0S46_RS12710	COG1285	pathogenesis
D0S46_RS12715	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D0S46_RS12735	COG0519	Catalyzes the synthesis of GMP from XMP
D0S46_RS12735	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D0S46_RS12775	COG0596	Alpha beta hydrolase
D0S46_RS12780	COG0745	RESPONSE REGULATOR receiver
D0S46_RS12785	COG2205	protein histidine kinase activity
D0S46_RS12800	COG0076	glutamate decarboxylase activity
D0S46_RS12805	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D0S46_RS12810	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D0S46_RS12815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D0S46_RS12820	COG1116	anion transmembrane transporter activity
D0S46_RS12825	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D0S46_RS12840	COG0673	inositol 2-dehydrogenase activity
D0S46_RS12850	COG1609	Transcriptional regulator
D0S46_RS12855	COG3706	GGDEF domain
D0S46_RS12860	COG0402	S-adenosylhomocysteine deaminase activity
D0S46_RS12865	COG1953	Uracil, thiamine, allantoin
D0S46_RS12900	COG0596	Alpha beta hydrolase
D0S46_RS12915	COG2207	Transcriptional regulator
D0S46_RS12930	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D0S46_RS12950	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D0S46_RS13005	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D0S46_RS13015	COG2070	2-Nitropropane dioxygenase
D0S46_RS13020	COG0583	DNA-binding transcription factor activity
D0S46_RS13030	COG1902	pentaerythritol trinitrate reductase activity
D0S46_RS13035	COG4529	Protein conserved in bacteria
D0S46_RS13040	COG0477	Major facilitator Superfamily
D0S46_RS13070	COG2223	nitrite transmembrane transporter activity
D0S46_RS13080	COG1609	Transcriptional regulator
D0S46_RS13085	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0S46_RS13095	COG3037	sugar-specific permease SgaT UlaA
D0S46_RS13100	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D0S46_RS13110	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0S46_RS13115	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0S46_RS13115	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0S46_RS13115	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
D0S46_RS13130	COG0583	DNA-binding transcription factor activity
D0S46_RS13135	COG0583	DNA-binding transcription factor activity
D0S46_RS13140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D0S46_RS13150	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D0S46_RS13165	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0S46_RS13175	COG1609	Transcriptional regulator
D0S46_RS13205	COG1652	LysM domain
D0S46_RS13235	COG0456	acetyltransferase
D0S46_RS13235	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
D0S46_RS13245	COG0667	Aldo Keto reductase
D0S46_RS13250	COG0667	Aldo Keto reductase
D0S46_RS13255	COG3386	PFAM SMP-30 Gluconolaconase
D0S46_RS13260	COG0667	Aldo Keto reductase
D0S46_RS13290	COG0251	oxidation-reduction process
D0S46_RS13295	COG0583	DNA-binding transcription factor activity
D0S46_RS13300	COG0626	cystathionine gamma-synthase activity
D0S46_RS13305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0S46_RS13310	COG0814	amino acid
D0S46_RS13315	COG0583	DNA-binding transcription factor activity
D0S46_RS13325	COG1294	oxidase, subunit
D0S46_RS13330	COG1271	oxidase subunit
D0S46_RS13340	COG3118	belongs to the thioredoxin family
D0S46_RS13370	COG0583	DNA-binding transcription factor activity
D0S46_RS13410	COG1929	Belongs to the glycerate kinase type-1 family
D0S46_RS13415	COG3835	regulator
D0S46_RS13425	COG0583	DNA-binding transcription factor activity
D0S46_RS13435	COG2186	Transcriptional regulator
D0S46_RS13440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0S46_RS13440	COG1263	PTS System
D0S46_RS13450	COG2814	Major facilitator Superfamily
D0S46_RS13455	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0S46_RS13455	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0S46_RS13475	COG2819	hydrolase of the alpha beta superfamily
D0S46_RS13480	COG5001	Diguanylate cyclase
D0S46_RS13480	COG3300	MHYT domain
D0S46_RS13515	COG3188	usher protein
D0S46_RS13535	COG3550	peptidyl-serine autophosphorylation
D0S46_RS13540	COG1396	sequence-specific DNA binding
D0S46_RS13545	COG2351	hydroxyisourate hydrolase activity
D0S46_RS13550	COG3195	allantoin biosynthetic process
D0S46_RS13550	COG3648	Uricase
D0S46_RS13555	COG2233	PERMEase
D0S46_RS13585	COG2207	Transcriptional regulator
D0S46_RS13600	COG4628	conserved protein (DUF2132)
D0S46_RS13620	COG2011	ABC-type metal ion transport system permease component
D0S46_RS13625	COG2070	2-Nitropropane dioxygenase
D0S46_RS13635	COG0477	Major facilitator Superfamily
D0S46_RS13710	COG2199	diguanylate cyclase activity
D0S46_RS13725	COG1012	belongs to the aldehyde dehydrogenase family
D0S46_RS13730	COG0583	DNA-binding transcription factor activity
D0S46_RS13740	COG0039	L-malate dehydrogenase activity
D0S46_RS13745	COG1349	DNA-binding transcription factor activity
D0S46_RS13750	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D0S46_RS13755	COG3395	kinase activity
D0S46_RS13765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D0S46_RS13770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D0S46_RS13775	COG2271	Major facilitator Superfamily
D0S46_RS13800	COG4977	sequence-specific DNA binding
D0S46_RS13810	COG0697	spore germination
D0S46_RS13815	COG2814	Major facilitator Superfamily
D0S46_RS13845	COG0683	leucine binding
D0S46_RS13850	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D0S46_RS13885	COG2223	nitrite transmembrane transporter activity
D0S46_RS13890	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D0S46_RS13905	COG1349	DNA-binding transcription factor activity
D0S46_RS13910	COG2084	Dehydrogenase
D0S46_RS13915	COG3395	kinase activity
D0S46_RS13920	COG0235	Class ii aldolase
D0S46_RS13925	COG3622	Belongs to the hyi family
D0S46_RS13930	COG2610	gluconate transmembrane transporter activity
D0S46_RS13935	COG3708	Transcriptional regulator
D0S46_RS13935	COG2207	Transcriptional regulator
D0S46_RS13950	COG2200	EAL domain
D0S46_RS13955	COG1546	Belongs to the CinA family
D0S46_RS13960	COG0071	Belongs to the small heat shock protein (HSP20) family
D0S46_RS13975	COG2197	response regulator
D0S46_RS13980	COG2135	peptidase activity
D0S46_RS13985	COG2207	Transcriptional regulator
D0S46_RS14000	COG4221	oxidoreductase activity
D0S46_RS14005	COG1802	Transcriptional regulator
D0S46_RS14010	COG0589	response to stress
D0S46_RS14015	COG0246	Mannitol dehydrogenase
D0S46_RS14020	COG2271	Major facilitator Superfamily
D0S46_RS14035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0S46_RS14050	COG0243	molybdopterin cofactor binding
D0S46_RS14055	COG0437	4 iron, 4 sulfur cluster binding
D0S46_RS14060	COG3302	dmso reductase anchor subunit
D0S46_RS14075	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D0S46_RS14080	COG1940	carbohydrate kinase activity
D0S46_RS14085	COG0583	DNA-binding transcription factor activity
D0S46_RS14090	COG2814	Major facilitator Superfamily
D0S46_RS14095	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
D0S46_RS14105	COG3591	Belongs to the peptidase S1B family
D0S46_RS14125	COG0628	permease
D0S46_RS14155	COG0679	Auxin Efflux Carrier
D0S46_RS14165	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D0S46_RS14190	COG3290	protein histidine kinase activity
D0S46_RS14195	COG4565	transcriptional regulatory protein
D0S46_RS14220	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
D0S46_RS14220	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D0S46_RS14240	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D0S46_RS14245	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D0S46_RS14255	COG0183	Belongs to the thiolase family
D0S46_RS14260	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D0S46_RS14270	COG1414	Transcriptional regulator
D0S46_RS14275	COG2840	Smr protein MutS2
D0S46_RS14280	COG0583	DNA-binding transcription factor activity
D0S46_RS14290	COG1473	amidohydrolase
D0S46_RS14295	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
D0S46_RS14310	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D0S46_RS14325	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D0S46_RS14330	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D0S46_RS14350	COG0531	amino acid
D0S46_RS14360	COG3136	membrane protein required for alginate biosynthesis
D0S46_RS14365	COG0745	RESPONSE REGULATOR receiver
D0S46_RS14375	COG2205	protein histidine kinase activity
D0S46_RS14385	COG0114	fumarate hydratase activity
D0S46_RS14390	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
D0S46_RS14390	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D0S46_RS14395	COG1482	cell wall glycoprotein biosynthetic process
D0S46_RS14400	COG5339	Protein conserved in bacteria
D0S46_RS14405	COG1609	Transcriptional regulator
D0S46_RS14410	COG1263	PTS System
D0S46_RS14410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0S46_RS14415	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D0S46_RS14440	COG2391	methyltransferase activity
D0S46_RS14445	COG0425	Belongs to the sulfur carrier protein TusA family
D0S46_RS14450	COG5562	phage envelope protein
D0S46_RS14455	COG0401	homolog of Blt101
D0S46_RS14460	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D0S46_RS14465	COG1012	belongs to the aldehyde dehydrogenase family
D0S46_RS14470	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D0S46_RS14475	COG0477	Major facilitator Superfamily
D0S46_RS14480	COG1113	amino acid transport
D0S46_RS14485	COG2988	succinylglutamate desuccinylase activity
D0S46_RS14490	COG3724	N-succinylarginine dihydrolase activity
D0S46_RS14495	COG1012	belongs to the aldehyde dehydrogenase family
D0S46_RS14500	COG3138	arginine N-succinyltransferase
D0S46_RS14505	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D0S46_RS14510	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D0S46_RS14515	COG0667	Aldo Keto reductase
D0S46_RS14520	COG0583	DNA-binding transcription factor activity
D0S46_RS14545	COG4122	O-methyltransferase activity
D0S46_RS14550	COG1643	Atp-dependent helicase
D0S46_RS14565	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D0S46_RS14570	COG3327	negative regulation of DNA-templated transcription, initiation
D0S46_RS14575	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
D0S46_RS14580	COG0183	Belongs to the thiolase family
D0S46_RS14585	COG2050	protein possibly involved in aromatic compounds catabolism
D0S46_RS14590	COG1250	3-hydroxyacyl-CoA dehydrogenase
D0S46_RS14595	COG1024	Enoyl-CoA hydratase
D0S46_RS14600	COG1024	Enoyl-CoA hydratase
D0S46_RS14605	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D0S46_RS14610	COG2151	metal-sulfur cluster biosynthetic enzyme
D0S46_RS14615	COG3396	Phenylacetate-CoA oxygenase
D0S46_RS14620	COG3460	Phenylacetate-CoA oxygenase
D0S46_RS14625	COG3396	Phenylacetate-CoA oxygenase
D0S46_RS14630	COG1012	belongs to the aldehyde dehydrogenase family
D0S46_RS14630	COG2030	dehydratase
D0S46_RS14655	COG1012	belongs to the aldehyde dehydrogenase family
D0S46_RS14660	COG2207	Transcriptional regulator
D0S46_RS14665	COG3784	Protein of unknown function (DUF1318)
D0S46_RS14675	COG2911	Protein conserved in bacteria
D0S46_RS14680	COG0586	Pfam SNARE associated Golgi protein
D0S46_RS14685	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D0S46_RS14690	COG3187	Heat shock protein
D0S46_RS14695	COG3042	response to heat
D0S46_RS14705	COG0674	pyruvate-flavodoxin oxidoreductase activity
D0S46_RS14705	COG1013	pyruvate-flavodoxin oxidoreductase activity
D0S46_RS14705	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D0S46_RS14705	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D0S46_RS14710	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D0S46_RS14720	COG0589	response to stress
D0S46_RS14730	COG0513	Belongs to the DEAD box helicase family
D0S46_RS14755	COG1349	DNA-binding transcription factor activity
D0S46_RS14760	COG0673	inositol 2-dehydrogenase activity
D0S46_RS14775	COG1113	amino acid transport
D0S46_RS14780	COG1522	sequence-specific DNA binding
D0S46_RS14790	COG1448	Aminotransferase
D0S46_RS14795	COG2011	ABC-type metal ion transport system permease component
D0S46_RS14805	COG1464	Belongs to the NlpA lipoprotein family
D0S46_RS14810	COG0436	Aminotransferase
D0S46_RS14815	COG0604	alcohol dehydrogenase
D0S46_RS14840	COG0583	DNA-binding transcription factor activity
D0S46_RS14860	COG1028	Short-chain dehydrogenase reductase Sdr
D0S46_RS14865	COG1309	transcriptional regulator
D0S46_RS14870	COG1028	Short-chain dehydrogenase reductase Sdr
D0S46_RS14945	COG2885	chlorophyll binding
D0S46_RS14970	COG0693	protein deglycase activity
D0S46_RS14975	COG1078	dGTPase activity
D0S46_RS14980	COG1028	Short-chain dehydrogenase reductase Sdr
D0S46_RS14985	COG0583	DNA-binding transcription factor activity
D0S46_RS15055	COG0784	Response regulator, receiver
D0S46_RS15055	COG2205	protein histidine kinase activity
D0S46_RS15055	COG5002	protein histidine kinase activity
D0S46_RS15060	COG3250	beta-galactosidase activity
D0S46_RS15065	COG0656	L-ascorbic acid biosynthetic process
D0S46_RS15095	COG4166	transmembrane transport
D0S46_RS15100	COG2866	Carboxypeptidase
D0S46_RS15105	COG4948	Mandelate Racemase Muconate Lactonizing
D0S46_RS15110	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D0S46_RS15115	COG3180	Ammonia monooxygenase
D0S46_RS15125	COG1486	melibiose metabolic process
D0S46_RS15130	COG0583	DNA-binding transcription factor activity
D0S46_RS15140	COG3106	COG3106 Predicted ATPase
D0S46_RS15150	COG1983	PspC domain protein
D0S46_RS15160	COG1842	Phage shock protein A
D0S46_RS15165	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D0S46_RS15175	COG1473	amidohydrolase
D0S46_RS15190	COG0702	epimerase
D0S46_RS15205	COG4171	peptide transport system, permease
D0S46_RS15220	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
D0S46_RS15230	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D0S46_RS15235	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D0S46_RS15235	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D0S46_RS15250	COG1349	DNA-binding transcription factor activity
D0S46_RS15260	COG0023	Translation Initiation Factor
D0S46_RS15270	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
D0S46_RS15275	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
D0S46_RS15280	COG0671	phosphoesterase, PA-phosphatase related
D0S46_RS15290	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D0S46_RS15320	COG0616	signal peptide processing
D0S46_RS15330	COG1028	Short-chain dehydrogenase reductase Sdr
D0S46_RS15335	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
D0S46_RS15365	COG0583	DNA-binding transcription factor activity
D0S46_RS15375	COG0009	L-threonylcarbamoyladenylate synthase
D0S46_RS15385	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D0S46_RS15390	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D0S46_RS15390	COG0512	Glutamine amidotransferase of anthranilate synthase
D0S46_RS15395	COG0134	indole-3-glycerol-phosphate synthase activity
D0S46_RS15395	COG0135	phosphoribosylanthranilate isomerase activity
D0S46_RS15450	COG4774	siderophore transport
D0S46_RS15460	COG3047	cAMP biosynthetic process
D0S46_RS15465	COG0727	PFAM Uncharacterised protein family (UPF0153)
D0S46_RS15495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0S46_RS15500	COG1028	Short-chain dehydrogenase reductase Sdr
D0S46_RS15505	COG1988	membrane-bound metal-dependent
D0S46_RS15520	COG0753	catalase activity
D0S46_RS15530	COG1486	melibiose metabolic process
D0S46_RS15535	COG1917	Cupin 2, conserved barrel domain protein
D0S46_RS15535	COG2169	Transcriptional regulator
D0S46_RS15540	COG1447	Phosphotransferase system cellobiose-specific component IIA
D0S46_RS15545	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0S46_RS15550	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0S46_RS15555	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0S46_RS15565	COG0322	excinuclease ABC activity
D0S46_RS15570	COG3678	ATP-independent chaperone mediated protein folding
D0S46_RS15580	COG3724	N-succinylarginine dihydrolase activity
D0S46_RS15590	COG3138	arginine N-succinyltransferase
D0S46_RS15600	COG0708	Exodeoxyribonuclease III
D0S46_RS15605	COG0398	Pfam SNARE associated Golgi protein
D0S46_RS15610	COG0398	Pfam SNARE associated Golgi protein
D0S46_RS15615	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D0S46_RS15620	COG4134	Bacterial extracellular solute-binding protein
D0S46_RS15625	COG4135	transport system, permease component
D0S46_RS15630	COG4136	ATPase activity
D0S46_RS15635	COG2897	thiosulfate sulfurtransferase activity
D0S46_RS15640	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D0S46_RS15645	COG0494	nUDIX hydrolase
D0S46_RS15650	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D0S46_RS15655	COG3321	synthase
D0S46_RS15655	COG1028	Short-chain dehydrogenase reductase Sdr
D0S46_RS15655	COG0604	alcohol dehydrogenase
D0S46_RS15665	COG0709	Synthesizes selenophosphate from selenide and ATP
D0S46_RS15685	COG0778	Nitroreductase
D0S46_RS15690	COG0616	signal peptide processing
D0S46_RS15695	COG0252	asparaginase activity
D0S46_RS15700	COG1335	isochorismatase
D0S46_RS15715	COG3139	Protein of unknown function (DUF1315)
D0S46_RS15735	COG0656	L-ascorbic acid biosynthetic process
D0S46_RS15740	COG3713	MltA-interacting MipA family protein
D0S46_RS15745	COG2766	serine protein kinase
D0S46_RS15760	COG0386	Belongs to the glutathione peroxidase family
D0S46_RS15780	COG1028	Short-chain dehydrogenase reductase Sdr
D0S46_RS15785	COG0583	DNA-binding transcription factor activity
D0S46_RS15790	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D0S46_RS15795	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D0S46_RS15800	COG3344	reverse transcriptase
D0S46_RS15815	COG0859	PFAM glycosyl transferase family 9
D0S46_RS15820	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D0S46_RS15830	COG2207	Transcriptional regulator
D0S46_RS15835	COG2807	transmembrane transport
D0S46_RS15840	COG0504	CTP synthase activity
D0S46_RS15845	COG1683	Conserved Protein
D0S46_RS15850	COG3189	MarR family transcriptional regulator
D0S46_RS15855	COG3042	response to heat
D0S46_RS15990	COG4695	Portal protein
D0S46_RS16010	COG0338	D12 class N6 adenine-specific DNA methyltransferase
D0S46_RS16055	COG4974	Belongs to the 'phage' integrase family
D0S46_RS16060	COG2199	diguanylate cyclase activity
D0S46_RS16060	COG2203	Gaf domain
D0S46_RS16080	COG3182	Iron-regulated membrane protein
D0S46_RS16090	COG1560	Kdo2-lipid A biosynthetic process
D0S46_RS16105	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D0S46_RS16110	COG3706	GGDEF domain
D0S46_RS16115	COG0583	DNA-binding transcription factor activity
D0S46_RS16120	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D0S46_RS16145	COG1294	oxidase, subunit
D0S46_RS16150	COG1271	oxidase subunit
D0S46_RS16155	COG3546	catalase activity
D0S46_RS16160	COG3685	Protein conserved in bacteria
D0S46_RS16165	COG3685	Protein conserved in bacteria
D0S46_RS16170	COG3729	General stress protein
D0S46_RS16175	COG1063	alcohol dehydrogenase
D0S46_RS16180	COG3813	Protein conserved in bacteria
D0S46_RS16200	COG0640	Transcriptional regulator
D0S46_RS16205	COG0538	isocitrate dehydrogenase activity
D0S46_RS16210	COG1187	pseudouridine synthase activity
D0S46_RS16230	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D0S46_RS16250	COG2205	protein histidine kinase activity
D0S46_RS16255	COG2850	peptidyl-arginine hydroxylation
D0S46_RS16275	COG1177	transmembrane transport
D0S46_RS16290	COG0318	PFAM AMP-dependent synthetase and ligase
D0S46_RS16295	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D0S46_RS16300	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D0S46_RS16305	COG0698	ribose 5-phosphate isomerase
D0S46_RS16320	COG3395	kinase activity
D0S46_RS16335	COG2390	Transcriptional regulator
D0S46_RS16345	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D0S46_RS16355	COG4591	ABC-type transport system involved in lipoprotein release permease component
D0S46_RS16365	COG4591	ABC-type transport system involved in lipoprotein release permease component
D0S46_RS16375	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D0S46_RS16380	COG1388	LysM domain
D0S46_RS16380	COG1376	ErfK ybiS ycfS ynhG family protein
D0S46_RS16390	COG1309	transcriptional regulator
D0S46_RS16400	COG3134	Outer membrane lipoprotein
D0S46_RS16405	COG1252	NADH dehydrogenase
D0S46_RS16430	COG5633	Lipoprotein
D0S46_RS16435	COG0537	adenosine 5'-monophosphoramidase activity
D0S46_RS16445	COG0084	hydrolase, TatD family'
D0S46_RS16450	COG0470	DNA polymerase III
D0S46_RS16460	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D0S46_RS16465	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D0S46_RS16470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D0S46_RS16485	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D0S46_RS16505	COG1399	metal-binding, possibly nucleic acid-binding protein
D0S46_RS16530	COG0583	DNA-binding transcription factor activity
D0S46_RS16535	COG2814	Major facilitator Superfamily
D0S46_RS16555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0S46_RS16605	COG1560	Kdo2-lipid A biosynthetic process
D0S46_RS16625	COG5645	(Lipo)protein
D0S46_RS16665	COG3381	protein complex oligomerization
D0S46_RS16690	COG0583	DNA-binding transcription factor activity
D0S46_RS16700	COG1335	isochorismatase
D0S46_RS16710	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D0S46_RS16715	COG1702	phosphate starvation-inducible protein PhoH
D0S46_RS16735	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D0S46_RS16745	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0S46_RS16765	COG1309	transcriptional regulator
D0S46_RS16800	COG2233	PERMEase
D0S46_RS16810	COG3729	General stress protein
D0S46_RS16835	COG1028	Short-chain dehydrogenase reductase Sdr
D0S46_RS16850	COG0531	amino acid
D0S46_RS16860	COG0174	glutamine synthetase
D0S46_RS16865	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D0S46_RS16870	COG1396	sequence-specific DNA binding
D0S46_RS16870	COG1917	Cupin 2, conserved barrel domain protein
D0S46_RS16875	COG1012	belongs to the aldehyde dehydrogenase family
D0S46_RS16880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D0S46_RS16885	COG0583	DNA-binding transcription factor activity
D0S46_RS16890	COG0473	3-isopropylmalate dehydrogenase activity
D0S46_RS16900	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0S46_RS16905	COG4638	Rieske (2fe-2S)
D0S46_RS16910	COG1012	belongs to the aldehyde dehydrogenase family
D0S46_RS16915	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D0S46_RS16920	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D0S46_RS16920	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0S46_RS16920	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0S46_RS16925	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0S46_RS16930	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0S46_RS16935	COG1882	Formate acetyltransferase
D0S46_RS16940	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D0S46_RS16945	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0S46_RS16955	COG2207	Transcriptional regulator
D0S46_RS16960	COG3706	GGDEF domain
D0S46_RS16980	COG2200	EAL domain
D0S46_RS16990	COG0058	SHG alpha-glucan phosphorylase activity
D0S46_RS17005	COG0670	Belongs to the BI1 family
D0S46_RS17020	COG2207	Transcriptional regulator
D0S46_RS17025	COG1881	PFAM PEBP family protein
D0S46_RS17050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0S46_RS17055	COG2274	protein secretion by the type I secretion system
D0S46_RS17075	COG1832	CoA-binding protein
D0S46_RS17085	COG0210	DNA helicase
D0S46_RS17090	COG3304	Inner membrane component domain
D0S46_RS17095	COG1289	transmembrane transporter activity
D0S46_RS17100	COG3070	regulator of competence-specific genes
D0S46_RS17125	COG1067	ATP-dependent peptidase activity
D0S46_RS17135	COG3130	regulation of translation
D0S46_RS17145	COG3009	Protein conserved in bacteria
D0S46_RS17150	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D0S46_RS17150	COG3008	intermembrane lipid transfer
D0S46_RS17155	COG2995	paraquat-inducible protein a
D0S46_RS17160	COG0488	(ABC) transporter
D0S46_RS17170	COG0633	Ferredoxin
D0S46_RS17170	COG3217	Mosc domain protein beta barrel domain protein
D0S46_RS17185	COG0431	NADPH-dependent FMN reductase
D0S46_RS17190	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D0S46_RS17195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D0S46_RS17200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D0S46_RS17210	COG0308	aminopeptidase N
D0S46_RS17225	COG1473	amidohydrolase
D0S46_RS17235	COG0814	amino acid
D0S46_RS17255	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D0S46_RS17260	COG1448	Aminotransferase
D0S46_RS17265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D0S46_RS17270	COG3108	Peptidase M15
D0S46_RS17280	COG2989	Protein conserved in bacteria
D0S46_RS17290	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
D0S46_RS17300	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D0S46_RS17305	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D0S46_RS17310	COG3173	Aminoglycoside phosphotransferase
D0S46_RS17325	COG3214	Protein conserved in bacteria
D0S46_RS17340	COG0658	competence protein
D0S46_RS17340	COG2333	competence protein COMEC
D0S46_RS17350	COG0539	negative regulation of cytoplasmic translation
D0S46_RS17370	COG2323	membrane
D0S46_RS17375	COG1944	ATP diphosphatase activity
D0S46_RS17380	COG2116	formate transmembrane transporter activity
D0S46_RS17385	COG1882	Formate acetyltransferase
D0S46_RS17390	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D0S46_RS17395	COG0477	Major facilitator Superfamily
D0S46_RS17405	COG3302	dmso reductase anchor subunit
D0S46_RS17410	COG0437	4 iron, 4 sulfur cluster binding
D0S46_RS17415	COG0243	molybdopterin cofactor binding
D0S46_RS17425	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D0S46_RS17435	COG1178	ABC-type Fe3 transport system permease component
D0S46_RS17435	COG1674	ftsk spoiiie
D0S46_RS17445	COG0492	ferredoxin-NADP+ reductase activity
D0S46_RS17450	COG4988	ABC transporter
D0S46_RS17455	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D0S46_RS17470	COG0542	response to heat
D0S46_RS17480	COG1278	Cold shock
D0S46_RS17495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0S46_RS17500	COG3593	DNA synthesis involved in DNA repair
D0S46_RS17510	COG2431	L-lysine efflux transmembrane transporter activity
D0S46_RS17520	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D0S46_RS17535	COG0028	Belongs to the TPP enzyme family
D0S46_RS17540	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
D0S46_RS17545	COG0702	epimerase
D0S46_RS17550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D0S46_RS17555	COG3023	N-Acetylmuramoyl-L-alanine amidase
D0S46_RS17560	COG2203	Gaf domain
D0S46_RS17560	COG3706	GGDEF domain
D0S46_RS17560	COG4251	negative regulation of phosphorylation
D0S46_RS17560	COG5001	Diguanylate cyclase
D0S46_RS17575	COG1126	abc transporter atp-binding protein
D0S46_RS17580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0S46_RS17585	COG4215	(ABC) transporter
D0S46_RS17590	COG4160	amino acid transport
D0S46_RS17595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0S46_RS17600	COG5002	protein histidine kinase activity
D0S46_RS17605	COG0745	RESPONSE REGULATOR receiver
D0S46_RS17620	COG1177	transmembrane transport
D0S46_RS17625	COG1176	ABC-type spermidine putrescine transport system, permease component I
D0S46_RS17630	COG3842	ATPase activity
D0S46_RS17635	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D0S46_RS17650	COG0778	Nitroreductase
D0S46_RS17675	COG3226	Transcriptional regulator
D0S46_RS17680	COG0738	Major facilitator superfamily
D0S46_RS17685	COG0561	phosphatase activity
D0S46_RS17690	COG2814	Major facilitator Superfamily
D0S46_RS17700	COG0671	phosphoesterase, PA-phosphatase related
D0S46_RS17705	COG1349	DNA-binding transcription factor activity
D0S46_RS17710	COG1686	Belongs to the peptidase S11 family
D0S46_RS17715	COG0625	glutathione transferase activity
D0S46_RS17720	COG2133	pyrroloquinoline quinone binding
D0S46_RS17730	COG2223	nitrite transmembrane transporter activity
D0S46_RS17755	COG0747	negative chemotaxis
D0S46_RS17770	COG0303	'Molybdopterin
D0S46_RS17775	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D0S46_RS17780	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D0S46_RS17785	COG1882	Formate acetyltransferase
D0S46_RS17790	COG0561	phosphatase activity
D0S46_RS17800	COG1609	Transcriptional regulator
D0S46_RS17805	COG2271	Major facilitator Superfamily
D0S46_RS17820	COG0488	(ABC) transporter
D0S46_RS17825	COG2365	Tyrosine phosphatase family
D0S46_RS17830	COG1376	ErfK ybiS ycfS ynhG family protein
D0S46_RS17835	COG2188	Transcriptional regulator
D0S46_RS17840	COG2723	6-phospho-beta-galactosidase activity
D0S46_RS17845	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D0S46_RS17860	COG2194	sulfuric ester hydrolase activity
D0S46_RS17865	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D0S46_RS17880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0S46_RS17885	COG0765	amino acid transport
D0S46_RS17890	COG1126	abc transporter atp-binding protein
D0S46_RS17895	COG0668	transmembrane transport
D0S46_RS17905	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D0S46_RS17915	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D0S46_RS17925	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D0S46_RS17930	COG1199	ATP-dependent helicase activity
D0S46_RS17935	COG0513	Belongs to the DEAD box helicase family
D0S46_RS17940	COG3958	Transketolase
D0S46_RS17945	COG3959	Transketolase, thiamine diphosphate binding domain
D0S46_RS17950	COG1028	Short-chain dehydrogenase reductase Sdr
D0S46_RS17955	COG2271	Major facilitator Superfamily
D0S46_RS17960	COG0583	DNA-binding transcription factor activity
D0S46_RS17965	COG1309	transcriptional regulator
D0S46_RS17970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0S46_RS17975	COG1131	(ABC) transporter
D0S46_RS17980	COG0842	Transport permease protein
D0S46_RS17985	COG0842	Transport permease protein
D0S46_RS18000	COG3568	Endonuclease Exonuclease Phosphatase
D0S46_RS18005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D0S46_RS18010	COG0392	lysyltransferase activity
D0S46_RS18030	COG0670	Belongs to the BI1 family
D0S46_RS18035	COG0314	molybdopterin synthase activity
D0S46_RS18040	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D0S46_RS18050	COG0521	Mo-molybdopterin cofactor biosynthetic process
D0S46_RS18075	COG0745	RESPONSE REGULATOR receiver
D0S46_RS18080	COG0642	Histidine kinase
D0S46_RS18115	COG2226	methyltransferase
D0S46_RS18135	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D0S46_RS18140	COG1881	PFAM PEBP family protein
D0S46_RS18175	COG4677	pectinesterase activity
D0S46_RS18185	COG0589	response to stress
D0S46_RS18190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0S46_RS18220	COG0789	Transcriptional regulator
D0S46_RS18225	COG2200	EAL domain
D0S46_RS18250	COG0561	phosphatase activity
D0S46_RS18260	COG4149	molybdate abc transporter
D0S46_RS18265	COG0725	ABC transporter, periplasmic molybdate-binding protein
D0S46_RS18275	COG2005	Transcriptional regulator
D0S46_RS18275	COG3585	molybdate ion transport
D0S46_RS18290	COG1085	galactose-1-phosphate uridylyltransferase
D0S46_RS18300	COG2017	converts alpha-aldose to the beta-anomer
D0S46_RS18310	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D0S46_RS18325	COG3201	nicotinamide mononucleotide transporter
D0S46_RS18330	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D0S46_RS18375	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
D0S46_RS18380	COG2885	chlorophyll binding
D0S46_RS18390	COG3064	Membrane
D0S46_RS18395	COG0848	biopolymer transport protein
D0S46_RS18400	COG0811	peptide transport
D0S46_RS18405	COG0824	Thioesterase
D0S46_RS18410	COG3790	cyd operon protein YbgE
D0S46_RS18415	COG4890	Cyd operon protein YbgT
D0S46_RS18420	COG1294	oxidase, subunit
D0S46_RS18425	COG1271	oxidase subunit
D0S46_RS18435	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D0S46_RS18445	COG0508	dehydrogenase complex catalyzes the overall conversion of
D0S46_RS18450	COG0567	Dehydrogenase, E1 component
D0S46_RS18455	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D0S46_RS18460	COG1053	succinate dehydrogenase
D0S46_RS18465	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
D0S46_RS18470	COG2009	succinate dehydrogenase
D0S46_RS18515	COG1984	allophanate hydrolase subunit 2
D0S46_RS18520	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D0S46_RS18535	COG0415	Belongs to the DNA photolyase family
D0S46_RS18565	COG2205	protein histidine kinase activity
D0S46_RS18570	COG0745	RESPONSE REGULATOR receiver
D0S46_RS18580	COG0033	Phosphoglucomutase
D0S46_RS18590	COG0596	Alpha beta hydrolase
D0S46_RS18605	COG0735	belongs to the Fur family
D0S46_RS18650	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D0S46_RS18655	COG1846	Transcriptional regulator
D0S46_RS18655	COG1940	carbohydrate kinase activity
D0S46_RS18660	COG0647	UMP catabolic process
D0S46_RS18665	COG0367	asparagine synthase
D0S46_RS18710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D0S46_RS18720	COG1702	phosphate starvation-inducible protein PhoH
D0S46_RS18745	COG0765	amino acid transport
D0S46_RS18750	COG0765	amino acid transport
D0S46_RS18755	COG1126	abc transporter atp-binding protein
D0S46_RS18770	COG2888	peptidyl-tyrosine sulfation
D0S46_RS18785	COG1466	dna polymerase III delta subunit
D0S46_RS18805	COG0799	negative regulation of ribosome biogenesis
D0S46_RS18815	COG0768	penicillin binding
D0S46_RS18820	COG0772	Belongs to the SEDS family
D0S46_RS18825	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D0S46_RS18830	COG1686	Belongs to the peptidase S11 family
D0S46_RS18845	COG0583	DNA-binding transcription factor activity
D0S46_RS18855	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D0S46_RS18860	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D0S46_RS18880	COG3069	C4-dicarboxylate transmembrane transporter activity
D0S46_RS18885	COG3719	Belongs to the RNase T2 family
D0S46_RS18890	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D0S46_RS18910	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D0S46_RS18915	COG0583	DNA-binding transcription factor activity
D0S46_RS18920	COG3969	phosphoadenosine phosphosulfate
D0S46_RS18925	COG1475	DNA binding
D0S46_RS18930	COG0436	Aminotransferase
D0S46_RS18955	COG1129	ABC transporter
D0S46_RS18960	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0S46_RS18965	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0S46_RS18975	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D0S46_RS18990	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
D0S46_RS19000	COG0402	S-adenosylhomocysteine deaminase activity
D0S46_RS19010	COG0483	inositol monophosphate 1-phosphatase activity
D0S46_RS19015	COG2271	Major facilitator Superfamily
D0S46_RS19045	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0S46_RS19050	COG1129	ABC transporter
D0S46_RS19055	COG0371	Dehydrogenase
D0S46_RS19060	COG1028	Short-chain dehydrogenase reductase Sdr
D0S46_RS19075	COG2879	small protein
D0S46_RS19080	COG1966	Carbon starvation protein
D0S46_RS19090	COG1028	Short-chain dehydrogenase reductase Sdr
D0S46_RS19095	COG1535	isochorismatase
D0S46_RS19095	COG3433	isochorismatase activity
D0S46_RS19100	COG1021	2,3-dihydroxybenzoate-AMP ligase
D0S46_RS19105	COG1169	isochorismate synthase
D0S46_RS19110	COG4592	Periplasmic binding protein
D0S46_RS19120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0S46_RS19125	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0S46_RS19130	COG1120	ATPase activity
D0S46_RS19140	COG3251	PFAM MbtH domain protein
D0S46_RS19145	COG2382	esterase
D0S46_RS19150	COG4771	TonB-dependent receptor
D0S46_RS19160	COG1879	ABC-type sugar transport system periplasmic component
D0S46_RS19170	COG1129	ABC transporter
D0S46_RS19175	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0S46_RS19180	COG5464	transposase or invertase
D0S46_RS19185	COG2390	Transcriptional regulator
D0S46_RS19190	COG3959	Transketolase, thiamine diphosphate binding domain
D0S46_RS19195	COG3958	Transketolase
D0S46_RS19205	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D0S46_RS19215	COG0583	DNA-binding transcription factor activity
D0S46_RS19220	COG0668	transmembrane transport
D0S46_RS19230	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0S46_RS19260	COG0747	negative chemotaxis
D0S46_RS19265	COG0601	transmembrane transport
D0S46_RS19270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0S46_RS19275	COG0444	Belongs to the ABC transporter superfamily
D0S46_RS19280	COG4608	Belongs to the ABC transporter superfamily
D0S46_RS19305	COG4221	oxidoreductase activity
D0S46_RS19315	COG4215	(ABC) transporter
D0S46_RS19320	COG0765	amino acid transport
D0S46_RS19325	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
D0S46_RS19340	COG0697	spore germination
D0S46_RS19355	COG4608	Belongs to the ABC transporter superfamily
D0S46_RS19360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0S46_RS19370	COG4166	transmembrane transport
D0S46_RS19380	COG3698	Phosphodiester glycosidase
D0S46_RS19425	COG2315	Protein conserved in bacteria
D0S46_RS19460	COG0477	Major facilitator Superfamily
D0S46_RS19465	COG0668	transmembrane transport
D0S46_RS19480	COG0673	inositol 2-dehydrogenase activity
D0S46_RS19490	COG2211	Major facilitator Superfamily
D0S46_RS19495	COG1113	amino acid transport
D0S46_RS19510	COG1012	belongs to the aldehyde dehydrogenase family
D0S46_RS19515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D0S46_RS19525	COG0531	amino acid
D0S46_RS19540	COG4680	protein conserved in bacteria
D0S46_RS19595	COG0667	Aldo Keto reductase
D0S46_RS19600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0S46_RS19605	COG1473	amidohydrolase
D0S46_RS19625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0S46_RS19630	COG1120	ATPase activity
D0S46_RS19635	COG1566	PFAM secretion protein HlyD family protein
D0S46_RS19680	COG4211	Belongs to the binding-protein-dependent transport system permease family
D0S46_RS19685	COG1129	ABC transporter
D0S46_RS19700	COG0673	inositol 2-dehydrogenase activity
D0S46_RS19735	COG3104	oligopeptide transport
D0S46_RS19740	COG1982	Orn Lys Arg decarboxylase major
D0S46_RS19745	COG0531	amino acid
D0S46_RS19750	COG3710	Transcriptional regulator
D0S46_RS19760	COG1560	Kdo2-lipid A biosynthetic process
D0S46_RS19810	COG2501	S4 domain
D0S46_RS19820	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D0S46_RS19840	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D0S46_RS19845	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D0S46_RS19860	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
D0S46_RS19865	COG4181	ATPase activity
D0S46_RS19870	COG2755	lipolytic protein G-D-S-L family
D0S46_RS19875	COG0300	oxidoreductase activity
D0S46_RS19880	COG3118	belongs to the thioredoxin family
D0S46_RS19890	COG0390	transport system, permease component
D0S46_RS19895	COG4619	ABC transporter
D0S46_RS19900	COG0330	HflC and HflK could
D0S46_RS19905	COG1585	Membrane protein implicated in regulation of membrane protease activity
D0S46_RS19920	COG3735	TraB family
D0S46_RS19925	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D0S46_RS19935	COG2223	nitrite transmembrane transporter activity
D0S46_RS19940	COG4651	solute:proton antiporter activity
D0S46_RS19940	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D0S46_RS19945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0S46_RS19990	COG2832	Protein of unknown function (DUF454)
D0S46_RS19995	COG3923	Primosomal replication protein n
D0S46_RS20005	COG5464	transposase or invertase
D0S46_RS20010	COG1196	nuclear chromosome segregation
D0S46_RS20010	COG3264	Mechanosensitive ion channel
D0S46_RS20015	COG1309	transcriptional regulator
D0S46_RS20020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0S46_RS20025	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0S46_RS20040	COG0110	maltose O-acetyltransferase activity
D0S46_RS20085	COG1874	Beta-galactosidase
D0S46_RS20090	COG3867	Arabinogalactan endo-beta-1,4-galactanase
D0S46_RS20095	COG3833	ABC-type maltose transport systems, permease component
D0S46_RS20100	COG1175	transmembrane transport
D0S46_RS20105	COG2182	Extracellular solute-binding protein
D0S46_RS20115	COG4943	cyclic-guanylate-specific phosphodiesterase activity
D0S46_RS20130	COG2364	Membrane
D0S46_RS20160	COG3695	enzyme binding
D0S46_RS20165	COG3126	Type III secretion system lipoprotein chaperone (YscW)
D0S46_RS20170	COG1946	Acyl-CoA thioesterase
D0S46_RS20175	COG0004	ammonium transporteR
D0S46_RS20180	COG0347	Belongs to the P(II) protein family
D0S46_RS20185	COG1132	(ABC) transporter
D0S46_RS20190	COG1132	(ABC) transporter
D0S46_RS20195	COG1522	sequence-specific DNA binding
D0S46_RS20210	COG4533	DNA binding
D0S46_RS20220	COG0824	Thioesterase
D0S46_RS20225	COG1555	photosystem II stabilization
D0S46_RS20230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D0S46_RS20235	COG0776	regulation of translation
D0S46_RS20240	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D0S46_RS20270	COG0271	Belongs to the BolA IbaG family
D0S46_RS20275	COG3056	Lipoprotein
D0S46_RS20280	COG2223	nitrite transmembrane transporter activity
D0S46_RS20285	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D0S46_RS20290	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D0S46_RS20295	COG1845	cytochrome c oxidase, subunit III
D0S46_RS20300	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D0S46_RS20315	COG1414	Transcriptional regulator
D0S46_RS20320	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D0S46_RS20325	COG1053	succinate dehydrogenase
D0S46_RS20335	COG1053	succinate dehydrogenase
D0S46_RS20350	COG0673	inositol 2-dehydrogenase activity
D0S46_RS20355	COG2814	Major facilitator Superfamily
D0S46_RS20365	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D0S46_RS20370	COG0693	protein deglycase activity
D0S46_RS20390	COG0142	geranyltranstransferase activity
D0S46_RS20400	COG0667	Aldo Keto reductase
D0S46_RS20405	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D0S46_RS20425	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D0S46_RS20425	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D0S46_RS20435	COG4238	major outer membrane lipoprotein
D0S46_RS20455	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D0S46_RS20460	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D0S46_RS20465	COG1862	Preprotein translocase
D0S46_RS20485	COG0450	alkyl hydroperoxide reductase
D0S46_RS20490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0S46_RS20505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0S46_RS20515	COG1228	amidohydrolase
D0S46_RS20525	COG1335	isochorismatase
D0S46_RS20530	COG0583	DNA-binding transcription factor activity
D0S46_RS20535	COG0366	Alpha amylase catalytic
D0S46_RS20560	COG0420	3'-5' exonuclease activity
D0S46_RS20565	COG0419	ATPase involved in DNA repair
D0S46_RS20570	COG1940	carbohydrate kinase activity
D0S46_RS20585	COG4126	flavin adenine dinucleotide binding
D0S46_RS20595	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D0S46_RS20600	COG3416	Protein conserved in bacteria
D0S46_RS20610	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D0S46_RS20620	COG1785	Belongs to the alkaline phosphatase family
D0S46_RS20660	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
D0S46_RS20665	COG1335	isochorismatase
D0S46_RS20670	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D0S46_RS20675	COG0113	porphobilinogen synthase activity
D0S46_RS20680	COG1943	Transposase
D0S46_RS20690	COG2175	clavaminate synthase activity
D0S46_RS20695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D0S46_RS20700	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D0S46_RS20705	COG4521	taurine ABC transporter
D0S46_RS20710	COG2040	homocysteine
D0S46_RS20715	COG0833	amino acid
D0S46_RS20725	COG4303	Ethanolamine ammonia lyase large subunit
D0S46_RS20730	COG4302	ethanolamine ammonia-lyase activity
D0S46_RS20765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0S46_RS20770	COG1126	abc transporter atp-binding protein
D0S46_RS20775	COG4597	amino acid ABC transporter
D0S46_RS20780	COG0765	amino acid transport
D0S46_RS20795	COG3188	usher protein
D0S46_RS20820	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
D0S46_RS20830	COG3639	organic phosphonate transmembrane transporter activity
D0S46_RS20855	COG0791	NLP P60 protein
D0S46_RS20880	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D0S46_RS20910	COG2909	trisaccharide binding
D0S46_RS20915	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D0S46_RS20920	COG0022	dehydrogenase e1 component
D0S46_RS20925	COG0508	dehydrogenase complex catalyzes the overall conversion of
D0S46_RS20930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D0S46_RS20955	COG1070	Carbohydrate kinase
D0S46_RS20960	COG1028	Short-chain dehydrogenase reductase Sdr
D0S46_RS20965	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D0S46_RS20970	COG3775	system Galactitol-specific IIC component
D0S46_RS20975	COG0625	glutathione transferase activity
D0S46_RS20980	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
D0S46_RS21000	COG0579	oxidoreductase
D0S46_RS21005	COG1012	belongs to the aldehyde dehydrogenase family
D0S46_RS21010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D0S46_RS21015	COG1113	amino acid transport
D0S46_RS21020	COG1802	Transcriptional regulator
D0S46_RS21040	COG2195	Cleaves the N-terminal amino acid of tripeptides
D0S46_RS21045	COG0454	-acetyltransferase
D0S46_RS21060	COG2991	Protein conserved in bacteria
D0S46_RS21075	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D0S46_RS21080	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D0S46_RS21100	COG3034	peptidoglycan biosynthetic process
D0S46_RS21105	COG0121	glutamine amidotransferase
D0S46_RS21115	COG1960	acyl-CoA dehydrogenase activity
D0S46_RS21120	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D0S46_RS21130	COG0583	DNA-binding transcription factor activity
D0S46_RS21145	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D0S46_RS21155	COG2226	methyltransferase
D0S46_RS21165	COG0741	lytic transglycosylase activity
D0S46_RS21165	COG1388	LysM domain
D0S46_RS21170	COG2226	methyltransferase
D0S46_RS21185	COG0583	DNA-binding transcription factor activity
D0S46_RS21190	COG0656	L-ascorbic acid biosynthetic process
D0S46_RS21230	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D0S46_RS21240	COG2011	ABC-type metal ion transport system permease component
D0S46_RS21245	COG1464	Belongs to the NlpA lipoprotein family
D0S46_RS21255	COG1720	tRNA m6t6A37 methyltransferase activity
D0S46_RS21265	COG0791	NLP P60 protein
D0S46_RS21270	COG3015	lipoprotein NlpE involved in copper resistance
D0S46_RS21275	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
D0S46_RS21290	COG4568	rho-dependent transcription termination
D0S46_RS21300	COG0346	lactoylglutathione lyase activity
D0S46_RS21315	COG0587	DNA-directed DNA polymerase activity
D0S46_RS21345	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
D0S46_RS21355	COG0750	zinc metalloprotease
D0S46_RS21360	COG0575	Belongs to the CDS family
D0S46_RS21375	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D0S46_RS21400	COG0024	Methionine aminopeptidase
D0S46_RS21405	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D0S46_RS21420	COG3835	regulator
D0S46_RS21425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D0S46_RS21445	COG2860	membrane
D0S46_RS21465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0S46_RS21470	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D0S46_RS21475	COG1120	ATPase activity
D0S46_RS21480	COG4774	siderophore transport
D0S46_RS21485	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D0S46_RS21575	COG1643	Atp-dependent helicase
D0S46_RS21580	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D0S46_RS21600	COG0617	tRNA 3'-terminal CCA addition
D0S46_RS21605	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D0S46_RS21625	COG0726	polysaccharide deacetylase
D0S46_RS21630	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0S46_RS21635	COG0842	Transport permease protein
D0S46_RS21640	COG1131	(ABC) transporter
D0S46_RS21645	COG0288	reversible hydration of carbon dioxide
D0S46_RS21655	COG4993	Dehydrogenase
D0S46_RS21660	COG2132	Multicopper oxidase
D0S46_RS21705	COG3064	Membrane
D0S46_RS21720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D0S46_RS21725	COG0508	dehydrogenase complex catalyzes the overall conversion of
D0S46_RS21730	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D0S46_RS21735	COG2186	Transcriptional regulator
D0S46_RS21740	COG1113	amino acid transport
D0S46_RS21745	COG2211	Major facilitator Superfamily
D0S46_RS21750	COG3940	Belongs to the glycosyl hydrolase 43 family
D0S46_RS21755	COG3725	Membrane protein required for beta-lactamase induction
D0S46_RS21760	COG3023	N-Acetylmuramoyl-L-alanine amidase
D0S46_RS21770	COG4969	Belongs to the N-Me-Phe pilin family
D0S46_RS21775	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D0S46_RS21780	COG1459	type II secretion system
D0S46_RS21805	COG0494	nUDIX hydrolase
D0S46_RS21825	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D0S46_RS21830	COG0849	cell division
D0S46_RS21855	COG0772	Belongs to the SEDS family
D0S46_RS21870	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D0S46_RS21875	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D0S46_RS21880	COG0768	penicillin binding
D0S46_RS21905	COG1609	Transcriptional regulator
D0S46_RS21915	COG0028	Belongs to the TPP enzyme family
D0S46_RS21965	COG0738	Major facilitator superfamily
D0S46_RS21975	COG0583	DNA-binding transcription factor activity
D0S46_RS21980	COG2271	Major facilitator Superfamily
D0S46_RS21985	COG2814	Major facilitator Superfamily
D0S46_RS22005	COG1178	ABC-type Fe3 transport system permease component
D0S46_RS22015	COG0586	Pfam SNARE associated Golgi protein
D0S46_RS22035	COG0235	Class ii aldolase
D0S46_RS22040	COG0417	DNA replication proofreading
D0S46_RS22050	COG0564	pseudouridine synthase activity
D0S46_RS22065	COG3493	citrate carrier protein
D0S46_RS22080	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D0S46_RS22085	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D0S46_RS22095	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D0S46_RS22145	COG0505	Belongs to the CarA family
D0S46_RS22160	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D0S46_RS22170	COG3152	Membrane
D0S46_RS22185	COG1047	Peptidyl-prolyl cis-trans
D0S46_RS22200	COG0196	riboflavin kinase activity
D0S46_RS22215	COG0583	DNA-binding transcription factor activity
D0S46_RS22240	COG4735	regulation of single-species biofilm formation
D0S46_RS22245	COG1584	GPR1 FUN34 yaaH family protein
D0S46_RS22250	COG0477	Major facilitator Superfamily
D0S46_RS22255	COG0521	Mo-molybdopterin cofactor biosynthetic process
D0S46_RS22260	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D0S46_RS22265	COG1115	amino acid carrier protein
D0S46_RS22280	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D0S46_RS22290	COG0460	homoserine dehydrogenase
D0S46_RS22290	COG0527	aspartate kinase activity
D0S46_RS22300	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
D0S46_RS22315	COG0745	RESPONSE REGULATOR receiver
D0S46_RS22320	COG4452	Inner membrane protein CreD
D0S46_RS22325	COG2205	protein histidine kinase activity
D0S46_RS22330	COG0745	RESPONSE REGULATOR receiver
D0S46_RS22335	COG3045	CreA protein
D0S46_RS22340	COG2207	Transcriptional regulator
D0S46_RS22340	COG3708	Transcriptional regulator
D0S46_RS22360	COG0741	lytic transglycosylase activity
D0S46_RS22370	COG0488	(ABC) transporter
D0S46_RS22380	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D0S46_RS22385	COG0560	Phosphoserine phosphatase
D0S46_RS22395	COG3726	membrane protein affecting hemolysin expression
D0S46_RS22425	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D0S46_RS22430	COG0084	hydrolase, TatD family'
D0S46_RS22435	COG4667	esterase of the alpha-beta hydrolase superfamily
D0S46_RS22440	COG5487	UPF0391 membrane protein
D0S46_RS22445	COG2823	Periplasmic or secreted lipoprotein
D0S46_RS22455	COG1011	Hydrolase
D0S46_RS22460	COG0456	acetyltransferase
D0S46_RS22465	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
D0S46_RS22495	COG3706	GGDEF domain
D0S46_RS22500	COG4114	ferric iron reductase
D0S46_RS22505	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0S46_RS22505	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0S46_RS22510	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D0S46_RS22515	COG2197	response regulator
D0S46_RS22520	COG2197	response regulator
D0S46_RS22535	COG2966	Psort location CytoplasmicMembrane, score
D0S46_RS22550	COG1484	DNA-dependent DNA replication
D0S46_RS22565	COG5464	transposase or invertase
D0S46_RS22575	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D0S46_RS22580	COG3716	PTS system mannose fructose sorbose family IID component
D0S46_RS22585	COG3715	PTS system
D0S46_RS22600	COG3933	PFAM sigma-54 factor interaction domain-containing protein
D0S46_RS22600	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D0S46_RS22605	COG1214	PFAM Peptidase M22, glycoprotease
D0S46_RS22605	COG0456	acetyltransferase
D0S46_RS22615	COG1737	Transcriptional regulator
D0S46_RS22620	COG0800	Aldolase
D0S46_RS22625	COG3734	2-keto-3-deoxy-galactonokinase
D0S46_RS22640	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
D0S46_RS22670	COG1846	Transcriptional regulator
D0S46_RS22675	COG0179	Fumarylacetoacetate (FAA) hydrolase
D0S46_RS22685	COG1012	belongs to the aldehyde dehydrogenase family
D0S46_RS22690	COG3384	dioxygenase
D0S46_RS22700	COG3971	2-oxopent-4-enoate hydratase activity
D0S46_RS22720	COG2368	4-hydroxyphenylacetate
D0S46_RS22725	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D0S46_RS22740	COG1966	Carbon starvation protein
D0S46_RS22745	COG2879	small protein
D0S46_RS22750	COG0523	cobalamin synthesis protein
D0S46_RS22760	COG1012	belongs to the aldehyde dehydrogenase family
D0S46_RS22765	COG5464	transposase or invertase
D0S46_RS22770	COG1917	Cupin 2, conserved barrel domain protein
D0S46_RS22770	COG2207	Transcriptional regulator
D0S46_RS22780	COG2733	membrane
D0S46_RS22795	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
D0S46_RS22800	COG1924	4 iron, 4 sulfur cluster binding
D0S46_RS22815	COG1566	PFAM secretion protein HlyD family protein
D0S46_RS22825	COG5457	Domain of unknown function (DUF1127)
D0S46_RS22830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0S46_RS22840	COG0583	DNA-binding transcription factor activity
D0S46_RS22845	COG2249	NAD(P)H dehydrogenase (quinone) activity
D0S46_RS22855	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0S46_RS22860	COG1129	ABC transporter
D0S46_RS22865	COG1879	ABC-type sugar transport system periplasmic component
D0S46_RS22875	COG3706	GGDEF domain
D0S46_RS22880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0S46_RS22885	COG0842	Transport permease protein
D0S46_RS22885	COG1129	ABC transporter
D0S46_RS22890	COG0842	Transport permease protein
D0S46_RS22925	COG2850	peptidyl-arginine hydroxylation
D0S46_RS22940	COG5002	protein histidine kinase activity
D0S46_RS22945	COG0745	RESPONSE REGULATOR receiver
D0S46_RS22955	COG1538	Outer membrane efflux protein
D0S46_RS22960	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0S46_RS22965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0S46_RS22970	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0S46_RS22980	COG3040	lipid binding
D0S46_RS22985	COG0789	Transcriptional regulator
D0S46_RS22990	COG3631	Ketosteroid isomerase-related protein
D0S46_RS22995	COG0300	oxidoreductase activity
D0S46_RS23010	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D0S46_RS23030	COG3272	Protein of unknown function (DUF1722)
D0S46_RS23035	COG4580	involved in the transport of maltose and maltodextrins
D0S46_RS23040	COG2115	Belongs to the xylose isomerase family
D0S46_RS23045	COG2211	Major facilitator Superfamily
D0S46_RS23050	COG3507	Belongs to the glycosyl hydrolase 43 family
D0S46_RS23070	COG1216	Glycosyl transferase, family 2
D0S46_RS23130	COG1715	Restriction endonuclease
D0S46_RS23135	COG1196	nuclear chromosome segregation
D0S46_RS23155	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
D0S46_RS23160	COG0582	viral genome integration into host DNA
D0S46_RS23175	COG0288	reversible hydration of carbon dioxide
D0S46_RS23180	COG0659	secondary active sulfate transmembrane transporter activity
D0S46_RS23185	COG1064	alcohol dehydrogenase
D0S46_RS23190	COG1175	transmembrane transport
D0S46_RS23195	COG0395	ABC-type sugar transport system, permease component
D0S46_RS23200	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D0S46_RS23205	COG3842	ATPase activity
D0S46_RS23220	COG1082	Xylose isomerase domain protein TIM barrel
D0S46_RS23230	COG3962	Belongs to the TPP enzyme family
D0S46_RS23235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0S46_RS23240	COG1737	Transcriptional regulator
D0S46_RS23240	COG0837	glucose binding
D0S46_RS23265	COG3718	enzyme involved in inositol metabolism
D0S46_RS23280	COG0433	COG0433 Predicted ATPase
D0S46_RS23285	COG0795	lipopolysaccharide-transporting ATPase activity
D0S46_RS23290	COG0795	lipopolysaccharide-transporting ATPase activity
D0S46_RS23305	COG2927	DNA polymerase III (CHI subunit)
D0S46_RS23310	COG0525	valine-tRNA ligase activity
D0S46_RS23335	COG2731	YhcH YjgK YiaL family protein
D0S46_RS23380	COG1263	PTS System
D0S46_RS23380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0S46_RS23385	COG0366	Alpha amylase catalytic
D0S46_RS23390	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0S46_RS23395	COG1486	melibiose metabolic process
D0S46_RS23415	COG0602	queuosine metabolic process
D0S46_RS23420	COG2026	Addiction module toxin, RelE StbE family
D0S46_RS23425	COG3077	Addiction module antitoxin, RelB DinJ family
D0S46_RS23430	COG3711	transcriptional antiterminator
D0S46_RS23430	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0S46_RS23435	COG2706	6-phosphogluconolactonase activity
D0S46_RS23450	COG3964	amidohydrolase
D0S46_RS23485	COG0312	modulator of DNA gyrase
D0S46_RS23505	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D0S46_RS23515	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0S46_RS23520	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0S46_RS23525	COG1129	ABC transporter
D0S46_RS23530	COG1879	ABC-type sugar transport system periplasmic component
D0S46_RS23545	COG2105	PFAM AIG2 family protein
D0S46_RS23550	COG2911	Protein conserved in bacteria
D0S46_RS23555	COG0729	surface antigen
D0S46_RS23565	COG1253	flavin adenine dinucleotide binding
D0S46_RS23590	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
D0S46_RS23605	COG1733	regulation of RNA biosynthetic process
D0S46_RS23610	COG0702	epimerase
D0S46_RS23620	COG0697	spore germination
D0S46_RS23630	COG1113	amino acid transport
D0S46_RS23635	COG0545	Peptidyl-prolyl cis-trans isomerase
D0S46_RS23640	COG3061	Opacity-associated protein A
D0S46_RS23650	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D0S46_RS23655	COG2965	DNA replication, synthesis of RNA primer
D0S46_RS23715	COG1073	alpha beta
D0S46_RS23720	COG3650	response to hydrogen peroxide
D0S46_RS23730	COG1960	acyl-CoA dehydrogenase activity
D0S46_RS23735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D0S46_RS23740	COG0557	exoribonuclease II activity
D0S46_RS23755	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
D0S46_RS23765	COG0330	HflC and HflK could
D0S46_RS23770	COG0330	HflC and HflK could
D0S46_RS23775	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D0S46_RS23795	COG0860	N-Acetylmuramoyl-L-alanine amidase
D0S46_RS23800	COG0802	atpase or kinase
D0S46_RS23805	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D0S46_RS23805	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D0S46_RS23810	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D0S46_RS23835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0S46_RS23860	COG3264	Mechanosensitive ion channel
D0S46_RS23860	COG1511	domain protein
D0S46_RS23875	COG1053	succinate dehydrogenase
D0S46_RS23880	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D0S46_RS23900	COG2076	Multidrug Resistance protein
D0S46_RS23905	COG5510	response to toxic substance
D0S46_RS23920	COG1509	lysine 2,3-aminomutase activity
D0S46_RS23985	COG0531	amino acid
D0S46_RS23990	COG3030	protein affecting phage T7 exclusion by the F plasmid
D0S46_RS24000	COG1027	Aspartate ammonia-lyase
D0S46_RS24005	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D0S46_RS24020	COG1309	transcriptional regulator
D0S46_RS24050	COG0457	Tetratricopeptide repeat
D0S46_RS24055	COG1649	PFAM Uncharacterised BCR, COG1649
D0S46_RS24055	COG0726	polysaccharide deacetylase
D0S46_RS24060	COG1215	transferase activity, transferring glycosyl groups
D0S46_RS24080	COG0861	Integral membrane protein TerC family
D0S46_RS24110	COG1486	melibiose metabolic process
D0S46_RS24120	COG2169	Transcriptional regulator
D0S46_RS24135	COG2824	Alkylphosphonate utilization operon protein PhnA
D0S46_RS24140	COG2764	glyoxalase bleomycin resistance protein dioxygenase
D0S46_RS24145	COG2188	Transcriptional regulator
D0S46_RS24150	COG3624	Phosphonate C-P lyase system protein PhnG
D0S46_RS24155	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
D0S46_RS24160	COG3626	phosphonate metabolism
D0S46_RS24165	COG3627	carbon phosphorus lyase activity
D0S46_RS24170	COG4107	phosphonate C-P lyase system protein PhnK
D0S46_RS24175	COG4778	phosphonate C-P lyase system protein PhnL
D0S46_RS24180	COG3454	Phosphonate metabolism
D0S46_RS24190	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D0S46_RS24200	COG4191	Histidine kinase
D0S46_RS24200	COG0784	Response regulator, receiver
D0S46_RS24205	COG1129	ABC transporter
D0S46_RS24210	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0S46_RS24245	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
D0S46_RS24250	COG1301	dicarboxylic acid transport
D0S46_RS24260	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D0S46_RS24270	COG3162	membrane
D0S46_RS24300	COG3539	Fimbrial protein
D0S46_RS24305	COG1346	cytolysis
D0S46_RS24310	COG1380	Effector of murein hydrolase LrgA
D0S46_RS24315	COG0583	DNA-binding transcription factor activity
D0S46_RS24320	COG0025	NhaP-type Na H and K H
D0S46_RS24325	COG2252	PERMEase
D0S46_RS24330	COG0625	glutathione transferase activity
D0S46_RS24335	COG0789	Transcriptional regulator
D0S46_RS24345	COG4943	cyclic-guanylate-specific phosphodiesterase activity
D0S46_RS24380	COG1234	tRNA 3'-trailer cleavage
D0S46_RS24385	COG1609	Transcriptional regulator
D0S46_RS24390	COG0483	inositol monophosphate 1-phosphatase activity
D0S46_RS24405	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0S46_RS24425	COG4771	TonB-dependent receptor
D0S46_RS24430	COG0741	lytic transglycosylase activity
D0S46_RS24450	COG2315	Protein conserved in bacteria
D0S46_RS24455	COG0432	Pfam Uncharacterised protein family UPF0047
D0S46_RS24470	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D0S46_RS24475	COG0305	Participates in initiation and elongation during chromosome replication
D0S46_RS24490	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D0S46_RS24500	COG0735	belongs to the Fur family
D0S46_RS24505	COG3237	CsbD-like
D0S46_RS24510	COG0534	Mate efflux family protein
D0S46_RS24520	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D0S46_RS24595	COG0251	oxidation-reduction process
D0S46_RS24605	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D0S46_RS24625	COG0527	aspartate kinase activity
D0S46_RS24675	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D0S46_RS24685	COG0456	acetyltransferase
D0S46_RS24725	COG0151	Belongs to the GarS family
D0S46_RS24735	COG4191	Histidine kinase
D0S46_RS24740	COG3678	ATP-independent chaperone mediated protein folding
D0S46_RS24775	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
D0S46_RS24790	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D0S46_RS24795	COG2104	thiamine diphosphate biosynthetic process
D0S46_RS24815	COG3706	GGDEF domain
D0S46_RS24825	COG1447	Phosphotransferase system cellobiose-specific component IIA
D0S46_RS24830	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D0S46_RS24870	COG0250	Participates in transcription elongation, termination and antitermination
D0S46_RS24920	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D0S46_RS24950	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
D0S46_RS24960	COG1739	Uncharacterized protein family UPF0029
D0S46_RS25005	COG0805	protein transport
D0S46_RS25025	COG3165	ubiquinone biosynthetic process from chorismate
D0S46_RS25055	COG0583	DNA-binding transcription factor activity
D0S46_RS25060	COG0697	spore germination
D0S46_RS25065	COG0561	phosphatase activity
D0S46_RS25070	COG2267	carboxylic ester hydrolase activity
D0S46_RS25075	COG1280	lysine exporter protein (LysE YggA)
D0S46_RS25085	COG1280	lysine exporter protein (LysE YggA)
D0S46_RS25120	COG0210	DNA helicase
D0S46_RS25125	COG1011	Hydrolase
D0S46_RS25155	COG3072	Adenylate cyclase
D0S46_RS25170	COG2959	enzyme of heme biosynthesis
D0S46_RS25175	COG3071	HemY protein
D0S46_RS25220	COG2244	polysaccharide biosynthetic process
D0S46_RS25225	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D0S46_RS25230	COG0456	acetyltransferase
D0S46_RS25235	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
D0S46_RS25240	COG1088	dTDP-glucose 4,6-dehydratase activity
D0S46_RS25245	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D0S46_RS25250	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
D0S46_RS25260	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D0S46_RS25265	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D0S46_RS25275	COG3118	belongs to the thioredoxin family
D0S46_RS25305	COG1811	Na channel or pump
D0S46_RS25315	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D0S46_RS25320	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D0S46_RS25330	COG0583	DNA-binding transcription factor activity
D0S46_RS25335	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D0S46_RS25350	COG3978	acetolactate synthase activity
D0S46_RS25370	COG3085	chromosome segregation
D0S46_RS25445	COG0583	DNA-binding transcription factor activity
D0S46_RS25470	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D0S46_RS25485	COG3443	Belongs to the bacterial solute-binding protein 9 family
D0S46_RS25490	COG2207	Transcriptional regulator
D0S46_RS25500	COG0371	Dehydrogenase
D0S46_RS25505	COG0697	spore germination
D0S46_RS25515	COG0583	DNA-binding transcription factor activity
D0S46_RS25525	COG0737	Belongs to the 5'-nucleotidase family
D0S46_RS25535	COG0527	aspartate kinase activity
D0S46_RS25535	COG0460	homoserine dehydrogenase
D0S46_RS25540	COG0626	cystathionine gamma-synthase activity
D0S46_RS25555	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D0S46_RS25560	COG1609	Transcriptional regulator
D0S46_RS25565	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D0S46_RS25580	COG1575	Belongs to the MenA family. Type 1 subfamily
D0S46_RS25600	COG3678	ATP-independent chaperone mediated protein folding
D0S46_RS25605	COG0745	RESPONSE REGULATOR receiver
D0S46_RS25610	COG2205	protein histidine kinase activity
D0S46_RS25615	COG2258	MOSC domain
D0S46_RS25620	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D0S46_RS25665	COG1129	ABC transporter
D0S46_RS25670	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0S46_RS25675	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0S46_RS25680	COG1454	alcohol dehydrogenase
D0S46_RS25690	COG2211	Major facilitator Superfamily
D0S46_RS25745	COG0437	4 iron, 4 sulfur cluster binding
D0S46_RS25750	COG2864	formate dehydrogenase
D0S46_RS25765	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D0S46_RS25775	COG0456	acetyltransferase
D0S46_RS25790	COG1011	Hydrolase
D0S46_RS25810	COG3852	Histidine kinase
D0S46_RS25820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D0S46_RS25850	COG0204	Acyl-transferase
D0S46_RS25860	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D0S46_RS25865	COG3084	Protein conserved in bacteria
D0S46_RS25875	COG1763	Mo-molybdopterin cofactor biosynthetic process
D0S46_RS25905	COG2186	Transcriptional regulator
D0S46_RS25910	COG0477	Major facilitator Superfamily
D0S46_RS25915	COG1609	Transcriptional regulator
D0S46_RS25920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0S46_RS25930	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0S46_RS25935	COG1129	ABC transporter
D0S46_RS25965	COG1522	sequence-specific DNA binding
D0S46_RS25970	COG0716	FMN binding
D0S46_RS25985	COG3312	ion transport
D0S46_RS26035	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D0S46_RS26130	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D0S46_RS26135	COG0573	inorganic phosphate transmembrane transporter activity
D0S46_RS26140	COG0581	inorganic phosphate transmembrane transporter activity
D0S46_RS26145	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D0S46_RS26150	COG0704	Plays a role in the regulation of phosphate uptake
D0S46_RS26165	COG2382	esterase
D0S46_RS26170	COG0363	glucosamine-6-phosphate deaminase activity
D0S46_RS26175	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0S46_RS26185	COG2252	PERMEase
D0S46_RS26190	COG0431	NADPH-dependent FMN reductase
D0S46_RS26195	COG2091	lysine biosynthetic process via aminoadipic acid
D0S46_RS26230	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D0S46_RS26265	COG0187	DNA topoisomerase II activity
D0S46_RS26270	COG0561	phosphatase activity
D0S46_RS26285	COG2186	Transcriptional regulator
D0S46_RS26290	COG3734	2-keto-3-deoxy-galactonokinase
D0S46_RS26295	COG0800	Aldolase
D0S46_RS26305	COG2271	Major facilitator Superfamily
D0S46_RS26310	COG0823	Involved in the tonB-independent uptake of proteins
D0S46_RS26315	COG5645	(Lipo)protein
D0S46_RS26330	COG3645	SOS response
D0S46_RS26340	COG2188	Transcriptional regulator
D0S46_RS26355	COG2149	membrane
D0S46_RS26375	COG2610	gluconate transmembrane transporter activity
D0S46_RS26380	COG0583	DNA-binding transcription factor activity
D0S46_RS26385	COG2814	Major facilitator Superfamily
D0S46_RS26410	COG0028	Belongs to the TPP enzyme family
D0S46_RS26415	COG0440	acetolactate synthase activity
D0S46_RS26420	COG2197	response regulator
D0S46_RS26430	COG2271	Major facilitator Superfamily
D0S46_RS26475	COG2188	Transcriptional regulator
D0S46_RS26500	COG4580	involved in the transport of maltose and maltodextrins
D0S46_RS26505	COG1447	Phosphotransferase system cellobiose-specific component IIA
D0S46_RS26510	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0S46_RS26510	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0S46_RS26520	COG1609	Transcriptional regulator
D0S46_RS26535	COG0583	DNA-binding transcription factor activity
D0S46_RS26540	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D0S46_RS26545	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D0S46_RS26550	COG2828	Protein conserved in bacteria
D0S46_RS26565	COG0697	spore germination
D0S46_RS26570	COG1263	PTS System
D0S46_RS26570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0S46_RS26580	COG2814	Major facilitator Superfamily
D0S46_RS26590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0S46_RS26625	COG0583	DNA-binding transcription factor activity
D0S46_RS26650	COG1464	Belongs to the NlpA lipoprotein family
D0S46_RS26665	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D0S46_RS26795	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D0S46_RS26830	COG4372	Transposase
D0S46_RS26835	COG3436	PFAM IS66 Orf2 family protein
D0S46_RS26865	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D0S46_RS26880	COG0431	NADPH-dependent FMN reductase
D0S46_RS26910	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D0S46_RS26975	COG2801	Transposase and inactivated derivatives
D0S46_RS26985	COG2801	Transposase and inactivated derivatives
D0S46_RS26995	COG0501	Belongs to the peptidase M48B family
D0S46_RS27015	COG0542	response to heat
D0S46_RS27020	COG0071	Belongs to the small heat shock protein (HSP20) family
D0S46_RS27140	COG4172	Belongs to the ABC transporter superfamily
D0S46_RS27155	COG0601	transmembrane transport
D0S46_RS27160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0S46_RS27190	COG1595	DNA-templated transcription, initiation
D0S46_RS27195	COG3712	iron ion homeostasis
D0S46_RS27200	COG4772	TonB-dependent receptor
D0S46_RS27205	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
D0S46_RS27210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0S46_RS27215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0S46_RS27220	COG1120	ATPase activity
D0S46_RS27225	COG3436	PFAM IS66 Orf2 family protein
D0S46_RS27255	COG1609	Transcriptional regulator
D0S46_RS27265	COG2223	nitrite transmembrane transporter activity
D0S46_RS27325	COG4372	Transposase
D0S46_RS27330	COG3436	PFAM IS66 Orf2 family protein
D0S46_RS27385	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
D0S46_RS27390	COG3012	SEC-C Motif Domain Protein
D0S46_RS27390	COG3318	Belongs to the UPF0149 family
D0S46_RS27415	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
D0S46_RS27640	COG5499	transcription regulator containing HTH domain
D0S46_RS27795	COG3344	reverse transcriptase
D0S46_RS28105	COG3344	reverse transcriptase
D0S46_RS28125	COG5642	Protein of unknown function (DUF2384)
D0S46_RS28130	COG5654	RES domain protein
D0S46_RS28190	COG0675	Transposase, IS605 OrfB family
D0S46_RS28200	COG2026	Addiction module toxin, RelE StbE family
D0S46_RS28210	COG0210	DNA helicase
D0S46_RS28315	COG3344	reverse transcriptase
D0S46_RS28425	COG0482	sulfurtransferase activity
D0S46_RS28445	COG3173	Aminoglycoside phosphotransferase
D0S46_RS28450	COG2801	Transposase and inactivated derivatives
D0S46_RS28515	COG0673	inositol 2-dehydrogenase activity
D0S46_RS28520	COG1324	tolerance protein
D0S46_RS28550	COG2826	transposase and inactivated derivatives, IS30 family
D0S46_RS28610	COG0789	Transcriptional regulator
D0S46_RS28685	COG4245	von Willebrand factor, type A
D0S46_RS28690	COG4245	von Willebrand factor, type A
D0S46_RS28700	COG4245	von Willebrand factor, type A
D0S46_RS28720	COG1358	cellular component organization or biogenesis
D0S46_RS28815	COG2916	Histone family protein nucleoid-structuring protein H-NS
D0S46_RS28830	COG2801	Transposase and inactivated derivatives
D0S46_RS28860	COG3436	PFAM IS66 Orf2 family protein
D0S46_RS28865	COG4372	Transposase
D0S46_RS28870	COG2205	protein histidine kinase activity
D0S46_RS28875	COG0745	RESPONSE REGULATOR receiver
D0S46_RS28880	COG1276	copper resistance
D0S46_RS28885	COG2372	response to copper ion
D0S46_RS28890	COG3667	copper resistance
D0S46_RS28895	COG2132	Multicopper oxidase
D0S46_RS28905	COG0739	heme binding
D0S46_RS28935	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0S46_RS28970	COG3436	PFAM IS66 Orf2 family protein
D0S46_RS28975	COG4372	Transposase
D0S46_RS29005	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0S46_RS29015	COG4943	cyclic-guanylate-specific phosphodiesterase activity
D0S46_RS29035	COG5001	Diguanylate cyclase
D0S46_RS29035	COG1716	ATPase activity
D0S46_RS29040	COG2203	Gaf domain
D0S46_RS29040	COG2199	diguanylate cyclase activity
D0S46_RS29220	COG0633	Ferredoxin
D0S46_RS29275	COG1484	DNA-dependent DNA replication
D0S46_RS29520	COG0675	Transposase, IS605 OrfB family
D0S46_RS30155	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D0S46_RS30200	COG1530	ribonuclease E activity
D0S46_RS30275	COG1119	ATPase activity