locus-tag class description GO012_RS00005 ENOG4105QTB Flavodoxin GO012_RS00010 ENOG4108VVK transcriptional Regulator, AsnC GO012_RS00015 ENOG4105CU9 asparagine synthetase A GO012_RS00030 ENOG4105DFH Transport of potassium into the cell (By similarity) GO012_RS00040 ENOG4105C2J ABC transporter GO012_RS00045 ENOG4105CNN ABC, transporter GO012_RS00050 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GO012_RS00055 ENOG4108RVA ribokinase GO012_RS00060 ENOG4105ETE Transcriptional regulator (LacI family GO012_RS00065 ENOG4105C0R drug resistance transporter emrb qaca subfamily GO012_RS00070 ENOG4107EJG GntR family transcriptional regulator GO012_RS00095 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b GO012_RS00100 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) GO012_RS00105 ENOG4105PC1 Conserved Protein GO012_RS00110 ENOG4105E27 serine threonine protein kinase GO012_RS00120 ENOG4106HNH Acyl-transferase GO012_RS00125 ENOG4105C2M dna polymerase I GO012_RS00130 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) GO012_RS00135 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) GO012_RS00140 ENOG4105D4P Coproporphyrinogen iii oxidase GO012_RS00145 ENOG4106FIY GO012_RS00150 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GO012_RS00155 ENOG4105CUX Signal transduction histidine kinase GO012_RS00160 ENOG4105C5F glutamine synthetase GO012_RS00170 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 GO012_RS00175 ENOG4107S2Z UPF0761 membrane protein GO012_RS00180 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) GO012_RS00185 ENOG4105SUU thioesterase domain GO012_RS00195 ENOG41068KX affects formate dehydrogenase-N GO012_RS00210 ENOG4108MG3 formate dehydrogenase GO012_RS00215 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein GO012_RS00225 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GO012_RS00235 ENOG4105CTQ phosphohexokinase GO012_RS00250 ENOG4105D2N Aldolase GO012_RS00295 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) GO012_RS00305 ENOG4105C0A alcohol dehydrogenase GO012_RS00310 ENOG4105CNN ABC, transporter GO012_RS00315 ENOG4105CNN ABC, transporter GO012_RS00320 ENOG4105C2J ABC transporter GO012_RS00325 ENOG4105D4B ABC, transporter GO012_RS00330 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) GO012_RS00335 ENOG4105DKG l-rhamnose isomerase GO012_RS00340 ENOG4105DET Rhamnulokinase GO012_RS00345 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) GO012_RS00350 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) GO012_RS00355 ENOG4107YRA Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) (By similarity) GO012_RS00360 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GO012_RS00365 ENOG4108RPX mosc domain containing protein GO012_RS00370 ENOG4105E0F Histidine kinase GO012_RS00375 ENOG4105E3W Two component transcriptional regulator (Winged helix family GO012_RS00380 ENOG4105FMW periplasmic GO012_RS00385 ENOG41076HS cation diffusion facilitator family transporter GO012_RS00400 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase GO012_RS00415 ENOG41063M6 Cell Division Protein GO012_RS00420 ENOG4105ETE Transcriptional regulator (LacI family GO012_RS00425 ENOG4105C25 Primosomal protein n' GO012_RS00430 ENOG4105VFB Binds the 23S rRNA (By similarity) GO012_RS00435 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) GO012_RS00440 ENOG4105C28 cystathionine GO012_RS00445 ENOG4105CFH Aspartokinase GO012_RS00455 ENOG4105CGH 5'-nucleotidase GO012_RS00460 ENOG4108Z8I decarboxylase GO012_RS00465 ENOG4108KB2 LysR family Transcriptional regulator GO012_RS00470 ENOG4105SYT Methylenetetrahydrofolate reductase GO012_RS00475 ENOG4108Q5Y Membrane GO012_RS00480 ENOG4105DCT glycerol dehydrogenase GO012_RS00485 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GO012_RS00490 ENOG4106R3P AraC family transcriptional regulator GO012_RS00495 ENOG4108MEK Metal-binding protein YodA GO012_RS00510 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase GO012_RS00515 ENOG4105CAS nag kinase GO012_RS00520 ENOG4105CH7 arginosuccinase GO012_RS00525 ENOG4105C5Q Transcriptional regulator GO012_RS00530 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) GO012_RS00535 ENOG4105EJ2 Transcriptional regulator GO012_RS00540 ENOG4108Y73 Membrane GO012_RS00545 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) GO012_RS00600 ENOG4108WFC UPF0438 protein yifE GO012_RS00605 ENOG4105C0P Mg chelatase subunit ChlI GO012_RS00620 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit GO012_RS00625 ENOG4105CM2 brancheD-chain amino acid aminotransferase GO012_RS00630 ENOG4105C01 Dihydroxy-acid dehydratase GO012_RS00635 ENOG4105C7B Threonine dehydratase GO012_RS00640 ENOG4105EMY transcriptional regulator GO012_RS00645 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GO012_RS00650 ENOG4105KQ5 peptidylprolyl cis-trans isomerase GO012_RS00655 ENOG4105KQ5 peptidylprolyl cis-trans isomerase GO012_RS00660 ENOG4105C4R Atp-dependent dna helicase GO012_RS00665 ENOG4108UQV Membrane GO012_RS00680 ENOG4105C9X ppx gppa phosphatase GO012_RS00685 ENOG4105C1J atp-dependent rna helicase GO012_RS00690 ENOG4105K63 Thioredoxin GO012_RS00700 ENOG4105ESV Glycosyl transferase, family 4 GO012_RS00705 ENOG4105SFE lipopolysaccharide biosynthesis protein GO012_RS00710 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GO012_RS00715 ENOG4108IJ1 Dehydrogenase GO012_RS00720 ENOG4105C1B dTDP-glucose 4-6-dehydratase GO012_RS00725 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) GO012_RS00730 ENOG4108WJ1 acetyltransferase GO012_RS00735 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GO012_RS00740 ENOG4105EGZ biosynthesis protein GO012_RS00745 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) GO012_RS00750 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) GO012_RS00755 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family GO012_RS00760 ENOG4105C85 amino acid GO012_RS00785 ENOG410601J HemY protein GO012_RS00790 ENOG4105ECF c-methyltransferase GO012_RS00795 ENOG41076E6 Uroporphyrinogen-III Synthase GO012_RS00800 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) GO012_RS00805 ENOG4107T0K Adenylate cyclase GO012_RS00810 ENOG4105XQ6 frataxin-like protein GO012_RS00815 ENOG4105S7Z (LipO)protein GO012_RS00825 ENOG4105CT0 Protein of unknown function, DUF484 GO012_RS00830 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GO012_RS00835 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant GO012_RS00840 ENOG4105C4R Atp-dependent dna helicase GO012_RS00845 ENOG4107QUT magnesium and cobalt transport protein CorA GO012_RS00850 ENOG4105FR1 rard protein GO012_RS00855 ENOG4108VUY thioesterase Superfamily protein GO012_RS00860 ENOG4105HDD phospholipase GO012_RS00865 ENOG4105C9U ATP-dependent DNA helicase RecQ GO012_RS00885 ENOG4108EUD Lysophospholipase GO012_RS00890 ENOG4105DQF Hydrolase GO012_RS00895 ENOG4105EMK carboxylate amino acid amine transporter GO012_RS00900 ENOG4105DZ2 Transcriptional regulator GO012_RS00905 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) GO012_RS00910 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) GO012_RS00915 ENOG4107SXA Phosphorylase GO012_RS00920 ENOG4105CGY Dna recombination protein GO012_RS00925 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GO012_RS00930 ENOG4105JC1 sterol-binding domain protein GO012_RS00935 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) GO012_RS00940 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GO012_RS00950 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GO012_RS00960 ENOG4105MDZ Transcriptional activator rfaH GO012_RS00965 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) GO012_RS00970 ENOG4107QK7 reductase GO012_RS00975 ENOG4105CHU acetyl-coa acetyltransferase GO012_RS00980 ENOG4108EIM Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities (By similarity) GO012_RS00985 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) GO012_RS00990 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GO012_RS00995 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) GO012_RS01000 ENOG4108RR8 protoporphyrinogen oxidase GO012_RS01035 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase GO012_RS01040 ENOG4105CS9 pantothenic acid kinase GO012_RS01065 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GO012_RS01070 ENOG4105PM1 preprotein translocase subunit SecE GO012_RS01075 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GO012_RS01080 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) GO012_RS01085 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) GO012_RS01100 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GO012_RS01105 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GO012_RS01110 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter GO012_RS01115 ENOG4105VCP PTS System GO012_RS01125 ENOG4106TD9 Diguanylate cyclase GO012_RS01130 ENOG4105D41 biosynthesis protein thiH GO012_RS01135 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) GO012_RS01140 ENOG4105WHD thiamine biosynthesis protein ThiS GO012_RS01145 ENOG4105D06 uba thif-type nad fad binding protein GO012_RS01150 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) GO012_RS01155 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) GO012_RS01160 ENOG4107MNS Has binding activity to the major sigma subunit of RNA polymerase. May be involved in replacement of the RNA polymerase sigma subunit from sigma-70 to sigma-S during the transition from exponential growth to the stationary phase (By similarity) GO012_RS01165 ENOG4105E09 nadh pyrophosphatase GO012_RS01170 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) GO012_RS01175 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) GO012_RS01180 ENOG4105R2J Conserved Protein GO012_RS01185 ENOG4105K70 DNA-binding protein GO012_RS01190 ENOG4108T8B Protein of unknown function (DUF1481) GO012_RS01195 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism GO012_RS01200 ENOG4105BZU Histidine kinase GO012_RS01210 ENOG4105C12 Phosphoribosylglycinamide synthetase GO012_RS01215 ENOG4105DC1 bifunctional purine biosynthesis protein purh GO012_RS01240 ENOG4105K5X acetyltransferase GO012_RS01245 ENOG4105CVG Homoserine O-transsuccinylase GO012_RS01250 ENOG4107QP3 malate synthase g GO012_RS01255 ENOG4108I9X Isocitrate lyase GO012_RS01260 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) GO012_RS01265 ENOG41069M3 Transcriptional regulator GO012_RS01270 ENOG4105C3R Methionine synthase GO012_RS01275 ENOG4105EAM Na Pi-cotransporter GO012_RS01285 ENOG4105FE9 pseudouridine synthase GO012_RS01290 ENOG4108ZR5 Conserved Protein GO012_RS01295 ENOG4105C09 Bile acid GO012_RS01300 ENOG4105CFH Aspartokinase GO012_RS01305 ENOG4107QP8 phosphohexose isomerase GO012_RS01310 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GO012_RS01320 ENOG4105KME endoribonuclease L-psp GO012_RS01335 ENOG4105CEM UPF0597 protein GO012_RS01340 ENOG4108VY7 phosphate-starvation-inducible protein PsiE GO012_RS01345 ENOG4105EG2 ABC transporter, permease GO012_RS01350 ENOG4105D56 permease protein GO012_RS01355 ENOG4107FKK extracellular solute-binding protein family 1 GO012_RS01365 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) GO012_RS01370 ENOG4107W52 maltose operon periplasmic protein GO012_RS01375 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) GO012_RS01380 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) GO012_RS01385 ENOG4105E55 glycerol-3-phosphate acyltransferase GO012_RS01390 ENOG41080IJ Diacylglycerol kinase GO012_RS01395 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GO012_RS01400 ENOG4107R73 Mate efflux family protein GO012_RS01405 ENOG4105VDW Csbd family GO012_RS01410 ENOG4105MYN Zinc uptake regulation protein GO012_RS01420 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GO012_RS01425 ENOG4105P4Z Phage shock protein G GO012_RS01430 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GO012_RS01435 ENOG4105CDU Replicative dna helicase GO012_RS01440 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GO012_RS01445 ENOG4105CGF Aromatic amino acid aminotransferase GO012_RS01455 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme GO012_RS01460 ENOG4105MSB protein, conserved in bacteria GO012_RS01465 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GO012_RS01470 ENOG4108UUM single-stranded DNA-binding protein GO012_RS01475 ENOG4105E4C Lytic transglycosylase catalytic GO012_RS01480 ENOG4107RNH Outer membrane receptor FepA GO012_RS01485 ENOG4108DMH HTH_ARAC GO012_RS01490 ENOG4105R0I Feruloyl esterase GO012_RS01500 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane GO012_RS01510 ENOG4105ECY inositol monophosphatase GO012_RS01515 ENOG4105ETE Transcriptional regulator (LacI family GO012_RS01520 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) GO012_RS01545 ENOG4105PMV Membrane GO012_RS01550 ENOG4108M8H domain protein GO012_RS01555 ENOG4108W3Q Transcriptional regulator GO012_RS01560 ENOG4108Z4X TRANSCRIPTIONal GO012_RS01565 ENOG4108K3A Glutathione S-transferase GO012_RS01570 ENOG4105C7N Xanthine uracil vitamin C permease GO012_RS01575 ENOG4105EEQ Na H antiporter GO012_RS01580 ENOG4105CMU LysR family (Transcriptional regulator GO012_RS01590 ENOG41067MG lrgb family GO012_RS01595 ENOG4105MX3 Fimbrial GO012_RS01600 ENOG4108VCD Chaperone GO012_RS01605 ENOG4105CW0 outer membrane usher protein GO012_RS01625 ENOG41062QD Membrane GO012_RS01630 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GO012_RS01640 ENOG4105CK2 sodium dicarboxylate symporter GO012_RS01645 ENOG41082ND Uncharacterized protein yjcO GO012_RS01665 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GO012_RS01670 ENOG4105CNN ABC, transporter GO012_RS01675 ENOG4105C2J ABC transporter GO012_RS01680 ENOG4105BZU Histidine kinase GO012_RS01690 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein GO012_RS01695 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) GO012_RS01700 ENOG4105FD8 phosphonate metabolism protein PhnM GO012_RS01705 ENOG4105HRV phosphonate c-p lyase system protein phnl GO012_RS01710 ENOG4105ENV phosphonate C-P lyase system protein PhnK GO012_RS01715 ENOG4105FT8 Phosphonate metabolism GO012_RS01720 ENOG4105EKV Phosphonate metabolism protein GO012_RS01725 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH GO012_RS01730 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG GO012_RS01735 ENOG4107RJJ Transcriptional regulator GO012_RS01740 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase GO012_RS01745 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA GO012_RS01750 ENOG4105CSH Transporter GO012_RS01755 ENOG4108K2B transcriptional regulator GO012_RS01760 ENOG4105F8D glycoside hydrolase family 4 GO012_RS01765 ENOG4105CT4 transporter GO012_RS01790 ENOG4108ZCF integral membrane protein GO012_RS01805 ENOG4105CND Glycosyl transferase, family 2 GO012_RS01810 ENOG4107BJW polysaccharide deacetylase GO012_RS01815 ENOG4108TUY outer membrane protein PgaA GO012_RS01850 ENOG4108SIC Transcriptional regulator GO012_RS01855 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) GO012_RS01865 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter GO012_RS01870 ENOG4108IJ0 Aspartate ammonia-lyase GO012_RS01875 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 GO012_RS01880 ENOG4105DVH amino acid GO012_RS01890 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GO012_RS01895 ENOG4108ZVF (LipO)protein GO012_RS01905 ENOG4108JJA ABC, transporter GO012_RS01910 ENOG4108MBX Secretion Protein GO012_RS01925 ENOG4105CW0 outer membrane usher protein GO012_RS01945 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein GO012_RS01960 ENOG4106BSU Entericidin B GO012_RS01965 ENOG4105KPY Small multidrug resistance protein GO012_RS01985 ENOG4105E33 succinate dehydrogenase GO012_RS01990 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) GO012_RS01995 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) GO012_RS02000 ENOG4107SC7 Inner membrane transporter yjeM GO012_RS02005 ENOG4105EGS Mechanosensitive ion channel GO012_RS02010 ENOG4105DJ4 phosphatidylserine decarboxylase GO012_RS02015 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GO012_RS02020 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) GO012_RS02025 ENOG4106TNF Periplasmic binding protein GO012_RS02045 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) GO012_RS02050 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) GO012_RS02055 ENOG4105K8N protein family UPF0079, ATPase GO012_RS02060 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GO012_RS02065 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) GO012_RS02075 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) GO012_RS02080 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GO012_RS02085 ENOG4107QJR hflk protein GO012_RS02090 ENOG4105EPW hflc protein GO012_RS02105 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GO012_RS02115 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) GO012_RS02120 ENOG4105C2N RNA methyltransferase TrmH family group 3 GO012_RS02125 ENOG4105CSU acyl-Coa dehydrogenase GO012_RS02130 ENOG4105S17 UPF0379 protein yjfN GO012_RS02135 ENOG4105WSB biofilm stress and motility protein A GO012_RS02140 ENOG4108MXZ Esterase GO012_RS02155 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC GO012_RS02160 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport GO012_RS02165 ENOG4106ETB IIa component GO012_RS02190 ENOG4105KIT UPF0379 protein yjfY GO012_RS02195 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) GO012_RS02200 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) GO012_RS02205 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GO012_RS02210 ENOG4105K9Q Binds to the 23S rRNA (By similarity) GO012_RS02215 ENOG4105FHY Opacity-associated protein A GO012_RS02220 ENOG4108V1T peptidylprolyl cis-trans isomerase GO012_RS02230 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) GO012_RS02235 ENOG4105DXC membrane GO012_RS02245 ENOG4105ECR NmrA family GO012_RS02250 ENOG4105KVH Transcriptional regulator GO012_RS02255 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic GO012_RS02260 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase GO012_RS02265 ENOG4108UUE Transcriptional regulator GO012_RS02270 ENOG41061GZ Protein of unknown function (DUF1107) GO012_RS02280 ENOG4105C37 (CBS) domain GO012_RS02290 ENOG4105CFU surface antigen GO012_RS02295 ENOG4105MA0 exported protein GO012_RS02300 ENOG4108ZHD aig2 family GO012_RS02310 ENOG4105F0N pyrophosphate phospho-hydrolase GO012_RS02315 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator GO012_RS02320 ENOG4105C2J ABC transporter GO012_RS02325 ENOG4107R9N ABC transporter GO012_RS02330 ENOG41062B0 ABC transporter, permease GO012_RS02335 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 GO012_RS02340 ENOG4105DFU Cell wall formation (By similarity) GO012_RS02355 ENOG4105N42 UPF0307 protein GO012_RS02360 ENOG4105CMS peptidase U62, modulator of DNA gyrase GO012_RS02365 ENOG4108XVM Cytochrome b(562) GO012_RS02395 ENOG41069H0 dihydroorotase EC 3.5.2.3 GO012_RS02410 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) GO012_RS02415 ENOG4105EMD TRANSCRIPTIONal GO012_RS02425 ENOG4105K4U addiction module toxin, RelE StbE family GO012_RS02430 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) GO012_RS02435 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase GO012_RS02450 ENOG4105F8D glycoside hydrolase family 4 GO012_RS02455 ENOG4105CK1 PTS System GO012_RS02460 ENOG4105CG3 alpha amylase, catalytic region GO012_RS02465 ENOG4105C5Y PTS System GO012_RS02470 ENOG4105D4X repressor GO012_RS02480 ENOG4105KME endoribonuclease L-psp GO012_RS02485 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) GO012_RS02490 ENOG4105CXT aspartate transcarbamylase GO012_RS02505 ENOG4105XEP YhcH YjgK YiaL family protein GO012_RS02515 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) GO012_RS02520 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase GO012_RS02525 ENOG4108MJ3 acetyltransferase GO012_RS02530 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GO012_RS02535 ENOG4105MYG DNA polymerase iii, chi subunit GO012_RS02540 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) GO012_RS02545 ENOG4108M8S permease YjgP YjgQ family protein GO012_RS02550 ENOG4108K5H permease YjgP YjgQ family protein GO012_RS02555 ENOG4105D7A ATP-binding protein GO012_RS02565 ENOG4105C26 Dehydrogenase GO012_RS02570 ENOG4105DH8 myo-inositol catabolism GO012_RS02575 ENOG4105CHC glucokinase (EC 2.7.1.2) GO012_RS02580 ENOG4105D7K pfkb domain protein GO012_RS02585 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) GO012_RS02590 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) GO012_RS02595 ENOG4105F0H myo-inositol catabolism protein GO012_RS02600 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) GO012_RS02610 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GO012_RS02615 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) GO012_RS02620 ENOG4105DRS transport system, permease GO012_RS02630 ENOG4105DQ4 alcohol dehydrogenase GO012_RS02635 ENOG4105CHH sulfate transporter GO012_RS02640 ENOG41077A9 carbonic anhydrase GO012_RS02735 ENOG4108W9T type 1 fimbriae regulatory protein GO012_RS02745 ENOG4108VCD Chaperone GO012_RS02770 ENOG4105DZY Pts system, glucitol sorbitol-specific GO012_RS02780 ENOG410787A Pts system, glucitol sorbitol-specific GO012_RS02785 ENOG4105HVQ Regulatory factor of maltose metabolism GO012_RS02895 ENOG4108ZNX Heat shock protein GO012_RS02900 ENOG4108IYH Dna topoisomerase GO012_RS02945 ENOG4105NI8 Cytosine-specific methyltransferase GO012_RS03005 ENOG4107S6X Glycosyl transferase, family 2 GO012_RS03025 ENOG4105DSG hydrolase family 43 GO012_RS03030 ENOG4105CT4 transporter GO012_RS03035 ENOG4105C93 Xylose Isomerase GO012_RS03040 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) GO012_RS03045 ENOG4107SEY Conserved Protein GO012_RS03065 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GO012_RS03080 ENOG4107FW0 short-chain dehydrogenase reductase GO012_RS03090 ENOG4108XDN Transcriptional regulator GO012_RS03095 ENOG4105QNF Outer membrane lipoprotein GO012_RS03105 ENOG4108IJF Heavy metal efflux pump, CzcA GO012_RS03110 ENOG4105EP1 Efflux transporter rnd family, mfp subunit GO012_RS03115 ENOG410624V efflux system protein GO012_RS03120 ENOG4105ENJ RND efflux system, outer membrane lipoprotein GO012_RS03125 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GO012_RS03130 ENOG4105GR3 Histidine kinase GO012_RS03145 ENOG4105EZE Cupin 4 family protein GO012_RS03175 ENOG4105CMI transporter GO012_RS03180 ENOG4105CJ1 ABC, transporter GO012_RS03185 ENOG4105D0S secretion protein (HlyD GO012_RS03195 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GO012_RS03200 ENOG4105C2J ABC transporter GO012_RS03205 ENOG4105CNN ABC, transporter GO012_RS03210 ENOG4105CNN ABC, transporter GO012_RS03215 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein GO012_RS03220 ENOG41064T2 transcriptional regulator, lysR family GO012_RS03230 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GO012_RS03235 ENOG4106DIZ Domain of unknown function (DUF1127) GO012_RS03245 ENOG4105EFX secretion protein, HlyD family GO012_RS03260 ENOG4105CIZ coA-substrate-specific enzyme activase GO012_RS03265 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase GO012_RS03275 ENOG41083G8 Multidrug resistance protein MdtM GO012_RS03280 ENOG4106BRA Membrane GO012_RS03290 ENOG4106AXJ AraC family transcriptional regulator GO012_RS03295 ENOG4105DNE Transposase GO012_RS03300 ENOG4105C26 Dehydrogenase GO012_RS03310 ENOG4105CKI cobalamin synthesis protein GO012_RS03315 ENOG4105VCD cytoplasmic protein GO012_RS03320 ENOG4105D22 carbon starvation protein GO012_RS03335 ENOG4107UWN reductase GO012_RS03340 ENOG4105EFA 4-hydroxyphenylacetate GO012_RS03355 ENOG4105CNV Aldolase GO012_RS03370 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase GO012_RS03375 ENOG4105C26 Dehydrogenase GO012_RS03385 ENOG4105ERH Fumarylacetoacetate hydrolase GO012_RS03395 ENOG4108V8F Transcriptional regulator, MarR family GO012_RS03405 ENOG4105DG4 malate L-lactate dehydrogenase GO012_RS03430 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 GO012_RS03435 ENOG4108RTU Aldolase GO012_RS03440 ENOG4106KNT transcriptional regulator GO012_RS03445 ENOG4105XYF acetyltransferase GO012_RS03455 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GO012_RS03465 ENOG4105KPI PTS system sorbose subfamily IIB component GO012_RS03470 ENOG4105ETZ PTS System GO012_RS03475 ENOG4105F3R pts system mannose fructose sorbose family iid GO012_RS03490 ENOG4105DNE Transposase GO012_RS03500 ENOG4105RI1 glycoprotein receptor GO012_RS03505 ENOG4106CVF DNA replication protein GO012_RS03510 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) GO012_RS03515 ENOG4107XM3 UPF0442 protein GO012_RS03520 ENOG4105DWK Membrane GO012_RS03525 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase GO012_RS03535 ENOG4108N8T regulatoR GO012_RS03540 ENOG4108T94 DNA-binding transcriptional activator BglJ GO012_RS03545 ENOG4108UIN ybak prolyl-trna synthetase associated region GO012_RS03550 ENOG4105CK1 PTS System GO012_RS03555 ENOG4108819 ferric iron reductase GO012_RS03560 ENOG4106TD9 Diguanylate cyclase GO012_RS03565 ENOG4105YBH Protein of unknown function (DUF1435) GO012_RS03585 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) GO012_RS03590 ENOG4108WPU DNA polymerase III subunit psi GO012_RS03595 ENOG4105KEG ribosomal-protein-alanine acetyltransferase GO012_RS03600 ENOG4105PAD Hydrolase GO012_RS03605 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) GO012_RS03610 ENOG4105K3G Periplasmic Protein GO012_RS03620 ENOG4108NRW Phospholipase, patatin family GO012_RS03625 ENOG4105EYA deoxyribonuclease GO012_RS03630 ENOG4105D9N nucleoside GO012_RS03640 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) GO012_RS03655 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) GO012_RS03660 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) GO012_RS03665 ENOG4105EAC phosphoserine phosphatase GO012_RS03670 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) GO012_RS03675 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase GO012_RS03680 ENOG4105C5H ABC transporter GO012_RS03685 ENOG4107SC1 transglycosylase GO012_RS03690 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) GO012_RS03695 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GO012_RS03700 ENOG4105CVJ phosphoglycerate mutase GO012_RS03705 ENOG4105UEI Transcriptional Regulator AraC Family GO012_RS03710 ENOG4108RH0 Crea protein GO012_RS03715 ENOG4105E3W Two component transcriptional regulator (Winged helix family GO012_RS03720 ENOG4105EB3 Histidine kinase GO012_RS03725 ENOG4105CT7 inner membrane cred family protein GO012_RS03730 ENOG41065U4 response regulator GO012_RS03735 ENOG410759A GO012_RS03740 ENOG4106FVC RNA methyltransferase GO012_RS03750 ENOG4105CFH Aspartokinase GO012_RS03755 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) GO012_RS03760 ENOG4105D98 threonine synthase GO012_RS03770 ENOG4105D1Q UPF0246 protein GO012_RS03775 ENOG4105BZG amino acid carrier protein GO012_RS03785 ENOG4108RIR Molybdenum cofactor biosynthesis protein GO012_RS03790 ENOG4105CSH Transporter GO012_RS03795 ENOG4106HK8 GPR1 FUN34 yaaH family protein GO012_RS03800 ENOG4108QUJ UPF0174 protein YaaW GO012_RS03805 ENOG4108WTA UPF0412 protein YaaI GO012_RS03810 ENOG4105CFG Acts as a chaperone (By similarity) GO012_RS03815 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GO012_RS03820 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) GO012_RS03825 ENOG41063Z6 transcriptional regulator, lysR family GO012_RS03840 ENOG4105DTN riboflavin biosynthesis protein ribF GO012_RS03850 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) GO012_RS03855 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase GO012_RS03865 ENOG4105DU0 nucleoside hydrolase GO012_RS03875 ENOG4105EXG Transcriptional regulator GO012_RS03880 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GO012_RS03885 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) GO012_RS03890 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GO012_RS03895 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GO012_RS03900 ENOG4105M5B (LipO)protein GO012_RS03910 ENOG4105CKD glutathione-regulated potassium-efflux system protein GO012_RS03915 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) GO012_RS03920 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) GO012_RS03930 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) GO012_RS03935 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) GO012_RS03945 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) GO012_RS03950 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) GO012_RS03955 ENOG4106YYS transcriptional regulatory protein GO012_RS03960 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GO012_RS03965 ENOG4105D2K citrate carrier protein GO012_RS03975 ENOG4105D3G Pseudouridine synthase GO012_RS03980 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) GO012_RS03985 ENOG4105CQ2 DNA polymerase GO012_RS03990 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase GO012_RS03995 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) GO012_RS04000 ENOG4105EF1 ribulokinase GO012_RS04010 ENOG4108KF1 Membrane GO012_RS04020 ENOG4106SMU thiamine transporter membrane protein GO012_RS04025 ENOG4105DP9 ABC transporter GO012_RS04040 ENOG4105S8Q sugar efflux transporter GO012_RS04045 ENOG4105DJB Major Facilitator Superfamily GO012_RS04050 ENOG4105C5Q Transcriptional regulator GO012_RS04055 ENOG4105FF2 Type I DHQase GO012_RS04060 ENOG4105EMV Major Facilitator GO012_RS04075 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GO012_RS04080 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GO012_RS04090 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GO012_RS04100 ENOG41064T2 transcriptional regulator, lysR family GO012_RS04105 ENOG4105C7K acetolactate synthase GO012_RS04110 ENOG4108ZP8 Acetolactate synthase small subunit GO012_RS04115 ENOG4107B7Y DNA-binding transcriptional regulator FruR GO012_RS04125 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) GO012_RS04130 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) GO012_RS04135 ENOG4105CJN penicillin-binding protein GO012_RS04140 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GO012_RS04145 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) GO012_RS04150 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) GO012_RS04160 ENOG4105CNI cell division protein FtsW GO012_RS04165 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GO012_RS04170 ENOG4105DFU Cell wall formation (By similarity) GO012_RS04175 ENOG4105CPF Cell wall formation (By similarity) GO012_RS04180 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) GO012_RS04185 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GO012_RS04190 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GO012_RS04195 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GO012_RS04200 ENOG4106Q9Y Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) GO012_RS04205 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GO012_RS04210 ENOG4105M6F mutator MutT protein GO012_RS04215 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) GO012_RS04220 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) GO012_RS04225 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GO012_RS04230 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GO012_RS04235 ENOG4105D7Q type ii secretion system GO012_RS04240 ENOG4107QHF type ii secretion system protein e GO012_RS04245 ENOG4108ZUW Major pilin subunit GO012_RS04250 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase GO012_RS04255 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase GO012_RS04260 ENOG4106A72 regulatory protein AmpE GO012_RS04265 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) GO012_RS04270 ENOG4105CT4 transporter GO012_RS04275 ENOG4105C85 amino acid GO012_RS04280 ENOG41073TP transcriptional regulator GO012_RS04285 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) GO012_RS04290 ENOG4107QSN dihydrolipoamide acetyltransferase GO012_RS04295 ENOG4107QN2 dihydrolipoyl dehydrogenase GO012_RS04310 ENOG4108NST exported protein GO012_RS04320 ENOG4107QIJ Aconitate hydratase 2 GO012_RS04325 ENOG4108ZIG UPF0231 protein GO012_RS04330 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) GO012_RS04335 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) GO012_RS04350 ENOG4108ZRK uncharacterized protein yacC GO012_RS04355 ENOG4105E3B Multicopper oxidase GO012_RS04360 ENOG4105DZG Dehydrogenase GO012_RS04365 ENOG4108UGV hypoxanthine phosphoribosyltransferase GO012_RS04370 ENOG41077A9 carbonic anhydrase GO012_RS04375 ENOG4105DA5 (ABC) transporter GO012_RS04380 ENOG4105E3A (ABC) transporter GO012_RS04385 ENOG4108YTN IIa component GO012_RS04390 ENOG4107BJW polysaccharide deacetylase GO012_RS04395 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) GO012_RS04400 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) GO012_RS04405 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) GO012_RS04410 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GO012_RS04415 ENOG4105DJ0 Poly(A) Polymerase GO012_RS04420 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) GO012_RS04425 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters GO012_RS04430 ENOG4105PW4 Sugar fermentation stimulation protein homolog GO012_RS04435 ENOG4107XID 2'-5' rna ligase GO012_RS04440 ENOG4105CQ7 ATP-dependent helicase GO012_RS04535 ENOG4105BZ4 penicillin-binding protein GO012_RS04540 ENOG4105E0K tonB-dependent siderophore receptor GO012_RS04545 ENOG4105E0A ABC, transporter GO012_RS04550 ENOG4105J76 Periplasmic binding protein GO012_RS04555 ENOG4105S6R Iron-hydroxamate transporter permease subunit GO012_RS04565 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GO012_RS04570 ENOG4105CMQ Chloride channel GO012_RS04575 ENOG4108YX9 iron--sulfur cluster insertion protein erpA GO012_RS04580 ENOG4105EN6 Membrane GO012_RS04585 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) GO012_RS04590 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) GO012_RS04595 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein GO012_RS04600 ENOG4105C0H protease GO012_RS04605 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR GO012_RS04610 ENOG4108T8E UPF0325 protein GO012_RS04620 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) GO012_RS04625 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GO012_RS04630 ENOG4105CE9 30S ribosomal protein S2 GO012_RS04640 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GO012_RS04650 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) GO012_RS04660 ENOG4105KNE Phosphatidate cytidylyltransferase GO012_RS04665 ENOG4105DZP Membrane-associated zinc metalloprotease GO012_RS04670 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane GO012_RS04675 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) GO012_RS04690 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GO012_RS04695 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GO012_RS04700 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GO012_RS04705 ENOG4105C0B DNA polymerase III (alpha subunit) GO012_RS04710 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) GO012_RS04715 ENOG4105CXN decarboxylase GO012_RS04720 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase GO012_RS04725 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GO012_RS04730 ENOG4105M1T rho-binding antiterminator GO012_RS04735 ENOG4105W1I UPF0253 protein GO012_RS04740 ENOG4108VWS Yaeq family GO012_RS04745 ENOG4108YZN class I peptide chain release factor GO012_RS04750 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion GO012_RS04755 ENOG4108UY0 (LipO)protein GO012_RS04760 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GO012_RS04765 ENOG4108R96 Methyltransferase, YaeB family GO012_RS04770 ENOG4108R8X outer membrane lipoprotein GO012_RS04775 ENOG4105D01 (LipO)protein GO012_RS04780 ENOG4108UMI ABC transporter, permease GO012_RS04785 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GO012_RS04790 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase GO012_RS04825 ENOG4105CV8 reductase GO012_RS04830 ENOG4105HEI LysR family (Transcriptional regulator GO012_RS04835 ENOG4105F27 Major Facilitator GO012_RS04845 ENOG4105F2W methyltransferase GO012_RS04850 ENOG4105E9H Lytic Murein transglycosylase GO012_RS04855 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) GO012_RS04860 ENOG4105D1A Methyltransferase GO012_RS04865 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GO012_RS04870 ENOG4107RZZ dna polymerase iii epsilon subunit GO012_RS04880 ENOG41090KR LysR family transcriptional Regulator GO012_RS04885 ENOG4108VP3 Lysine exporter protein (LysE YggA) GO012_RS04890 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase GO012_RS04895 ENOG4107QPN acyl-Coa dehydrogenase GO012_RS04900 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) GO012_RS04905 ENOG4105E7A Glutamine amidotransferase GO012_RS04910 ENOG4105F7V ErfK ybiS ycfS ynhG family protein GO012_RS04915 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GO012_RS04920 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GO012_RS04925 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GO012_RS04930 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GO012_RS04935 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GO012_RS04940 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) GO012_RS04955 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GO012_RS04960 ENOG4108HYG acetyltransferase GO012_RS04965 ENOG4105CIN aminoacyl-histidine dipeptidase GO012_RS04975 ENOG4105V1F Fermentation respiration switch protein GO012_RS04980 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) GO012_RS04985 ENOG4108PVQ transcriptional regulator GO012_RS04990 ENOG4105C85 amino acid GO012_RS04995 ENOG4108JPW Aminotransferase GO012_RS05000 ENOG4105C26 Dehydrogenase GO012_RS05005 ENOG4105D5U fad dependent oxidoreductase GO012_RS05015 ENOG4105YCT UPF0386 protein GO012_RS05020 ENOG4105DTA methyltransferase GO012_RS05025 ENOG4108TGY Glutathione S-transferase GO012_RS05030 ENOG4105DT3 PTS system, galactitol-specific IIc component GO012_RS05035 ENOG4108JQ1 Dehydrogenase GO012_RS05040 ENOG4105CHR reductase GO012_RS05045 ENOG4105CMG Carbohydrate kinase GO012_RS05055 ENOG41061GT Aldolase GO012_RS05065 ENOG4107QN2 dihydrolipoyl dehydrogenase GO012_RS05075 ENOG4105CPP Dehydrogenase, E1 component GO012_RS05080 ENOG4107R0V Pyruvate dehydrogenase GO012_RS05085 ENOG41061ZR Transcriptional regulator GO012_RS05125 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) GO012_RS05130 ENOG4105FCK Membrane GO012_RS05135 ENOG4108QBX (LipO)protein GO012_RS05155 ENOG4105S7S phosphonate abc transporter GO012_RS05165 ENOG4105EHI Phosphonate ABC transporter, periplasmic GO012_RS05175 ENOG4106JB4 Represses expression of the flagellar master operon flhDC, and consequently prevents flagellum biosynthesis and motility. Acts by binding to the regulatory region of the flhDC operon GO012_RS05180 ENOG4108GWT fimbrillin MatB GO012_RS05185 ENOG4108NN8 Fimbrial protein GO012_RS05190 ENOG4108N3D putative enzyme GO012_RS05195 ENOG4106PYX Receptor GO012_RS05205 ENOG4105DRP amino acid AbC transporter GO012_RS05210 ENOG4105EZ7 amino acid ABC transporter GO012_RS05215 ENOG4105CDA abc transporter atp-binding protein GO012_RS05220 ENOG4105CT1 (ABC) transporter GO012_RS05230 ENOG4108IV0 ABC, transporter GO012_RS05235 ENOG4105C0Z ABC transporter GO012_RS05240 ENOG4105CF8 branched-chain amino acid ABC transporter, permease GO012_RS05245 ENOG4105C32 Amino acid ABC transporter (Permease) GO012_RS05255 ENOG4107FQ9 ethanolamine ammonia-lyase GO012_RS05260 ENOG4105CPD ethanolamine ammonia-lyase GO012_RS05280 ENOG4108IQI permease GO012_RS05285 ENOG4107QK5 Homocysteine s-methyltransferase GO012_RS05290 ENOG4106FTQ Taurine ABC transporter, periplasmic GO012_RS05295 ENOG4108ETV ABC transporter GO012_RS05300 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component GO012_RS05305 ENOG4105E2B Taurine dioxygenase GO012_RS05315 ENOG4105D52 delta-aminolevulinic acid dehydratase GO012_RS05320 ENOG4107R6D beta-lactam binding protein AmpH GO012_RS05325 ENOG4108RWI nicotinamidase GO012_RS05330 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 GO012_RS05335 ENOG4107QS8 (LipO)protein GO012_RS05340 ENOG4105FR5 inner membrane protein YaiY GO012_RS05345 ENOG4105UNH Membrane GO012_RS05350 ENOG4105CPF Cell wall formation (By similarity) GO012_RS05370 ENOG4105G6Z alkaline phosphatase GO012_RS05375 ENOG4105VIF phosphate starvation-inducible protein GO012_RS05380 ENOG4105II7 pyrroline-5-carboxylate reductase GO012_RS05385 ENOG4108UPT UPF0178 protein GO012_RS05390 ENOG4105G4C Periplasmic ligand-binding sensor protein GO012_RS05395 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) GO012_RS05400 ENOG4105SS3 GO012_RS05405 ENOG4105HBA AroM protein GO012_RS05420 ENOG4105DKQ ROK family GO012_RS05425 ENOG4105EYH Exonuclease GO012_RS05430 ENOG4107RH8 nuclease SbcCD subunit D GO012_RS05435 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GO012_RS05440 ENOG4105BZU Histidine kinase GO012_RS05445 ENOG4105CWM branched-chain amino acid transport system II carrier protein GO012_RS05450 ENOG4105C85 amino acid GO012_RS05455 ENOG4107R28 alpha amylase, catalytic region GO012_RS05460 ENOG4105EQ1 Transcriptional regulator GO012_RS05465 ENOG4105CHJ isochorismatase hydrolase GO012_RS05475 ENOG4105CI2 imidazolone-5-propionate hydrolase GO012_RS05485 ENOG4108MGF sugar kinase GO012_RS05500 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia GO012_RS05505 ENOG4105D3R alkyl hydroperoxide reductase GO012_RS05510 ENOG4108ZYK Acyl carrier protein phosphodiesterase GO012_RS05525 ENOG4105VIE preprotein translocase, subunit YajC GO012_RS05530 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GO012_RS05535 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GO012_RS05550 ENOG4105DRB nucleoside-specific channel-forming protein GO012_RS05555 ENOG4108KIC (LipO)protein GO012_RS05565 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) GO012_RS05570 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) GO012_RS05575 ENOG4107YIM Involved in the transcription termination process (By similarity) GO012_RS05580 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) GO012_RS05585 ENOG4108ZAI phosphatidylglycerophosphatase a GO012_RS05590 ENOG4105CPC Aldo Keto reductase GO012_RS05595 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) GO012_RS05600 ENOG4105CTB Polyprenyl synthetase GO012_RS05610 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) GO012_RS05620 ENOG4107S0N DJ-1 family GO012_RS05625 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GO012_RS05635 ENOG4107RDB Major Facilitator GO012_RS05640 ENOG4105CIB oxidoreductase Domain protein GO012_RS05645 ENOG4105D2S major facilitator superfamily GO012_RS05655 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein GO012_RS05665 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein GO012_RS05670 ENOG4105E2X shikimate dehydrogenase GO012_RS05675 ENOG4107HP6 Transcriptional regulator GO012_RS05685 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GO012_RS05690 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) GO012_RS05695 ENOG4105CCU oxidase (Subunit III) GO012_RS05700 ENOG4105BZ9 Cytochrome C oxidase, subunit I GO012_RS05705 ENOG4105E2S oxidase) subunit II GO012_RS05710 ENOG4105EYM Major Facilitator superfamily GO012_RS05715 ENOG4105IEY (LipO)protein GO012_RS05720 ENOG4105M85 Bola protein GO012_RS05730 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation GO012_RS05740 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) GO012_RS05745 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) GO012_RS05750 ENOG4105K70 DNA-binding protein GO012_RS05755 ENOG4105EIN peptidylprolyl cis-trans isomerase GO012_RS05760 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein GO012_RS05765 ENOG4108TGP Thioesterase superfamily protein GO012_RS05770 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) GO012_RS05775 ENOG4108NFA extracellular solute-binding protein GO012_RS05780 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) GO012_RS05790 ENOG4108XM1 transcriptional regulator AsnC family GO012_RS05795 ENOG4105BZ1 (ABC) transporter GO012_RS05800 ENOG4105BZ1 (ABC) transporter GO012_RS05805 ENOG4108YZA Nitrogen regulatory protein pii GO012_RS05810 ENOG4105BZU Histidine kinase GO012_RS05815 ENOG4105C29 acyl-CoA thioesterase GO012_RS05820 ENOG4108MNP Glycoprotein polysaccharide metabolism GO012_RS05825 ENOG41080UX Methyltransferase GO012_RS05855 ENOG4108VW9 Membrane GO012_RS05860 ENOG41061MD high-affinity nickel-transporter GO012_RS05865 ENOG41090EM Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter GO012_RS05870 ENOG41066DG (EAL) domain protein GO012_RS05880 ENOG4107FKK extracellular solute-binding protein family 1 GO012_RS05890 ENOG4105EG2 ABC transporter, permease GO012_RS05900 ENOG4105C4C beta-galactosidase GO012_RS05905 ENOG4105CI1 PTS System GO012_RS05910 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) GO012_RS05915 ENOG4105ETE Transcriptional regulator (LacI family GO012_RS05940 ENOG4105GSJ Inner membrane protein ylaC GO012_RS05945 ENOG4108UW5 maltose o-acetyltransferase GO012_RS05955 ENOG4108UKR Biofilm formation regulator YbaJ GO012_RS05960 ENOG4105BZS acriflavin resistance protein GO012_RS05965 ENOG4105C1P efflux transporter, rnd family, mfp subunit GO012_RS05970 ENOG4108IG5 Transcriptional regulator GO012_RS05975 ENOG4105EGS Mechanosensitive ion channel GO012_RS05985 ENOG4106428 Protein of unknown function (DUF2496) GO012_RS05990 ENOG4108URS primosomal replication protein n'' GO012_RS05995 ENOG4105WD1 Membrane GO012_RS06000 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) GO012_RS06005 ENOG4107QMP dna polymerase iii subunits gamma and tau GO012_RS06015 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) GO012_RS06020 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) GO012_RS06035 ENOG4107RE1 Inosine-guanosine kinase GO012_RS06040 ENOG4105CKD glutathione-regulated potassium-efflux system protein GO012_RS06045 ENOG4105EU0 Major facilitator Superfamily GO012_RS06050 ENOG4105CGH 5'-nucleotidase GO012_RS06055 ENOG4108Z66 YbaK ebsC protein GO012_RS06060 ENOG4105MBR gumn family GO012_RS06065 ENOG4105C59 p-type ATPase GO012_RS06070 ENOG4108Z6Z Transcriptional regulator GO012_RS06075 ENOG4105G5H Membrane GO012_RS06080 ENOG4107QX8 SPFH domain, Band 7 family protein GO012_RS06085 ENOG41083J0 (ABC) transporter GO012_RS06090 ENOG4105C4B ABC transporter, permease GO012_RS06095 ENOG4107QR8 Thioredoxin GO012_RS06100 ENOG4105E1F short-chain dehydrogenase reductase GO012_RS06105 ENOG4108UJV acyl-CoA thioesterase i GO012_RS06110 ENOG4108I0Y (ABC) transporter GO012_RS06115 ENOG4105CV6 ABC transporter, permease GO012_RS06145 ENOG41060W2 glyoxylate carboligase GO012_RS06150 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) GO012_RS06155 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GO012_RS06165 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease GO012_RS06175 ENOG4105DTE Xanthine uracil vitamin C permease GO012_RS06180 ENOG4105BZW Glycerate kinase GO012_RS06185 ENOG4105S0E allantoin catabolism protein GO012_RS06190 ENOG4105CE7 Amidase, hydantoinase carbamoylase family GO012_RS06195 ENOG4105DG4 malate L-lactate dehydrogenase GO012_RS06200 ENOG4107R1Q Membrane protein FdrA GO012_RS06205 ENOG4107REC cytoplasmic protein GO012_RS06210 ENOG4105G5A Protein of unknown function (DUF2877) GO012_RS06215 ENOG4105C5B carbamate kinase GO012_RS06220 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit GO012_RS06225 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) GO012_RS06235 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) GO012_RS06240 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) GO012_RS06260 ENOG4105S2T inner membrane protein YbcI GO012_RS06265 ENOG4105WQ3 Rna-binding protein GO012_RS06295 ENOG4105BZN citrate synthase GO012_RS06310 ENOG4105X0I Fimbrial GO012_RS06315 ENOG4105GQR Chaperone GO012_RS06320 ENOG4105CW0 outer membrane usher protein GO012_RS06335 ENOG4105D1S lipid A biosynthesis GO012_RS06345 ENOG4108M3R transcriptional activator CadC GO012_RS06350 ENOG4105D5Q Arginine ornithine antiporter GO012_RS06355 ENOG4105CXN decarboxylase GO012_RS06360 ENOG4105DUX Transporter GO012_RS06365 ENOG4105CRK lysyL-tRNA synthetase GO012_RS06405 ENOG4105C2J ABC transporter GO012_RS06410 ENOG4108HWV )-transporter GO012_RS06420 ENOG4105WBN Transcriptional regulator (LacI family GO012_RS06425 ENOG4108HKT sucrose-6-phosphate hydrolase GO012_RS06430 ENOG4105C5Y PTS System GO012_RS06435 ENOG4108M0B Sucrose porin GO012_RS06440 ENOG4105D7K pfkb domain protein GO012_RS06450 ENOG4105KK7 inner membrane protein YiaW GO012_RS06455 ENOG4105EFX secretion protein, HlyD family GO012_RS06460 ENOG4105E0A ABC, transporter GO012_RS06465 ENOG4105EHG Permease protein GO012_RS06485 ENOG4105CH2 amidohydrolase GO012_RS06490 ENOG4105E89 ABC transporter GO012_RS06495 ENOG4105CPC Aldo Keto reductase GO012_RS06510 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) GO012_RS06520 ENOG4108UAJ Transcriptional regulator GO012_RS06530 ENOG4105DGU Histone deacetylase GO012_RS06540 ENOG4105CUB amino acid GO012_RS06550 ENOG4105CJP fad dependent oxidoreductase GO012_RS06555 ENOG4105C26 Dehydrogenase GO012_RS06560 ENOG4108NS2 receptor GO012_RS06570 ENOG4105C85 amino acid GO012_RS06575 ENOG4105EAA nucleoside GO012_RS06585 ENOG4105CK5 oxidoreductase GO012_RS06595 ENOG4105ETE Transcriptional regulator (LacI family GO012_RS06600 ENOG4105CUY Mechanosensitive ion channel GO012_RS06620 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GO012_RS06625 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine GO012_RS06630 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GO012_RS06635 ENOG4105F3R pts system mannose fructose sorbose family iid GO012_RS06645 ENOG4108IQ3 PTS system GO012_RS06655 ENOG4108RCM Nitroreductase GO012_RS06660 ENOG4105MSB protein, conserved in bacteria GO012_RS06665 ENOG410630P Transcriptional regulator GO012_RS06675 ENOG4105HFT AraC family transcriptional regulator GO012_RS06680 ENOG4105WQ6 Membrane GO012_RS06705 ENOG4108T58 Mg2 transport protein CorA GO012_RS06710 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) GO012_RS06725 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GO012_RS06740 ENOG4105CE7 Amidase, hydantoinase carbamoylase family GO012_RS06745 ENOG4105T38 integral membrane protein GO012_RS06750 ENOG4105CHM Aminotransferase GO012_RS06760 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) GO012_RS06765 ENOG4105DRP amino acid AbC transporter GO012_RS06770 ENOG4105GBT ABC transporter GO012_RS06780 ENOG4105EMU Dehydrogenase GO012_RS06785 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GO012_RS06795 ENOG4108JQ7 (ABC) transporter GO012_RS06800 ENOG4105C3U ABC transporter GO012_RS06805 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GO012_RS06810 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GO012_RS06815 ENOG4105DEF Extracellular solute-binding protein, family 5 GO012_RS06825 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) GO012_RS06840 ENOG4105C94 Transporter GO012_RS06845 ENOG4108WN0 inhibitor of vertebrate lysozyme GO012_RS06850 ENOG4105CUY Mechanosensitive ion channel GO012_RS06855 ENOG410810E transcriptional regulator, lysR family GO012_RS06865 ENOG4108R85 Short chain dehydrogenase GO012_RS06875 ENOG4105CNN ABC, transporter GO012_RS06880 ENOG4105C2J ABC transporter GO012_RS06890 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GO012_RS06895 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GO012_RS06900 ENOG4105DKT Transcriptional regulator GO012_RS06905 ENOG4108HHA Transketolase GO012_RS06910 ENOG4108IUS Transketolase GO012_RS06915 ENOG4108TSE Transferase GO012_RS06920 ENOG4107RNH Outer membrane receptor FepA GO012_RS06925 ENOG4105E93 esterase GO012_RS06930 ENOG41085A6 mbth domain-containing protein GO012_RS06935 ENOG4105C0W non-ribosomal peptide synthetase GO012_RS06940 ENOG4105E0A ABC, transporter GO012_RS06945 ENOG4105TVJ transport system, permease GO012_RS06950 ENOG4105DQ5 transport system permease protein GO012_RS06955 ENOG4105E8G Major facilitator Superfamily GO012_RS06960 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein GO012_RS06965 ENOG4105E4F Isochorismate synthase GO012_RS06970 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase GO012_RS06975 ENOG4105WQI isochorismatase GO012_RS06980 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase GO012_RS06985 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) GO012_RS06990 ENOG4105D22 carbon starvation protein GO012_RS06995 ENOG4105VCD cytoplasmic protein GO012_RS07010 ENOG4105F6U Short-chain dehydrogenase reductase Sdr GO012_RS07015 ENOG4107SCQ Iron-containing alcohol dehydrogenase GO012_RS07020 ENOG4105C2J ABC transporter GO012_RS07025 ENOG4105CNN ABC, transporter GO012_RS07040 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) GO012_RS07045 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) GO012_RS07050 ENOG4105D6F Phosphatase GO012_RS07055 ENOG4105CXY transporter GO012_RS07060 ENOG4105ECY inositol monophosphatase GO012_RS07065 ENOG4105ETE Transcriptional regulator (LacI family GO012_RS07070 ENOG4105DZC cytosine deaminase GO012_RS07080 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin GO012_RS07085 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) GO012_RS07095 ENOG4108M3J Dehydrogenase GO012_RS07105 ENOG4105CNN ABC, transporter GO012_RS07110 ENOG4105CNN ABC, transporter GO012_RS07115 ENOG4105C2J ABC transporter GO012_RS07130 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) GO012_RS07135 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) GO012_RS07140 ENOG4105CHM Aminotransferase GO012_RS07145 ENOG4105GTN ParB Domain Protein Nuclease GO012_RS07150 ENOG4105BZV Phosphoadenosine phosphosulfate reductase GO012_RS07155 ENOG4105DQS Transcriptional regulator GO012_RS07160 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase GO012_RS07165 ENOG4105D3R alkyl hydroperoxide reductase GO012_RS07170 ENOG4108JU3 Alkyl hydroperoxide reductase GO012_RS07175 ENOG4108U51 Universal stress protein GO012_RS07180 ENOG4105NXH GreA GreB family elongation factor GO012_RS07185 ENOG4105KTS ribonuclease GO012_RS07190 ENOG4105CEE C4-dicarboxylate transporter GO012_RS07195 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) GO012_RS07200 ENOG4105VEQ Cold shock protein GO012_RS07210 ENOG4107QPI nitrilase cyanide hydratase and apolipoprotein n-acyltransferase GO012_RS07215 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GO012_RS07225 ENOG41064T2 transcriptional regulator, lysR family GO012_RS07230 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) GO012_RS07240 ENOG4105DZ1 carboxypeptidase GO012_RS07245 ENOG4105K6T rare lipoprotein A GO012_RS07250 ENOG4105CNI cell division protein FtsW GO012_RS07255 ENOG4105CJN penicillin-binding protein GO012_RS07265 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) GO012_RS07270 ENOG4108TGR phosphatase GO012_RS07275 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) GO012_RS07280 ENOG4105DJF DNA polymerase III, delta' subunit GO012_RS07290 ENOG4105C8T Leucyl-tRNA synthetase GO012_RS07295 ENOG4107PAI alpha helical protein GO012_RS07310 ENOG4105CDA abc transporter atp-binding protein GO012_RS07315 ENOG4105DRP amino acid AbC transporter GO012_RS07320 ENOG4105EAD ABC transporter GO012_RS07325 ENOG4107RP9 extracellular solute-binding protein, family 3 GO012_RS07330 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) GO012_RS07335 ENOG4108JU5 Magnesium and cobalt efflux protein GO012_RS07345 ENOG4105C9A Phoh family GO012_RS07350 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GO012_RS07355 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family GO012_RS07395 ENOG4105CAQ asparagine synthetase GO012_RS07400 ENOG4105D4U had-superfamily hydrolase, subfamily iia GO012_RS07405 ENOG4105E2R ROK family GO012_RS07410 ENOG4105CE4 GlcNAc 6-P deacetylase GO012_RS07415 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) GO012_RS07420 ENOG4105CI1 PTS System GO012_RS07425 ENOG4105CX6 glutaminyL-tRNA synthetase GO012_RS07435 ENOG4105J5J Outer membrane porin GO012_RS07440 ENOG4105GX6 (LipO)protein GO012_RS07445 ENOG4105CSH Transporter GO012_RS07450 ENOG41090R7 Ferric uptake GO012_RS07455 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) GO012_RS07460 ENOG4105NNH LexA regulated protein GO012_RS07465 ENOG4105EV9 Alpha Beta Hydrolase GO012_RS07470 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) GO012_RS07475 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 GO012_RS07485 ENOG4105EEX Two component transcriptional regulator (Winged helix family GO012_RS07490 ENOG4105C08 Histidine kinase GO012_RS07495 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) GO012_RS07500 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) GO012_RS07505 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) GO012_RS07515 ENOG4105XIQ Protein of unknown function (DUF2517) GO012_RS07520 ENOG4105CVP deoxyribo-dipyrimidine photolyase GO012_RS07525 ENOG4105DUX Transporter GO012_RS07530 ENOG4107QNR UPF0135 protein GO012_RS07535 ENOG4105P4J Allophanate hydrolase, subunit 1 GO012_RS07540 ENOG4107R7A Allophanate hydrolase subunit 2 GO012_RS07545 ENOG4105E7W lamb ycsf family protein GO012_RS07565 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) GO012_RS07570 ENOG4105BZN citrate synthase GO012_RS07575 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit GO012_RS07580 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein GO012_RS07585 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) GO012_RS07590 ENOG4105E33 succinate dehydrogenase GO012_RS07595 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 GO012_RS07600 ENOG4105C7S Dehydrogenase GO012_RS07610 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha GO012_RS07620 ENOG4105C4M (Ubiquinol oxidase) subunit I GO012_RS07625 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GO012_RS07635 ENOG4105KJB cyd operon protein YbgE GO012_RS07640 ENOG4107YD3 Thioesterase GO012_RS07645 ENOG4105E02 MotA TolQ exbB proton channel GO012_RS07650 ENOG4105M8F Biopolymer transport protein exbD tolR GO012_RS07655 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA GO012_RS07665 ENOG4105KCK Peptidoglycan-associated lipoprotein GO012_RS07670 ENOG4105UFD tol-pal system protein YbgF GO012_RS07715 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) GO012_RS07720 ENOG4106Z1T Nicotinamide Mononucleotide Transporter GO012_RS07725 ENOG4105PGM cation diffusion facilitator family transporter GO012_RS07730 ENOG4105JND homeobox protein GO012_RS07735 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GO012_RS07745 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) GO012_RS07750 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) GO012_RS07755 ENOG4105F0Z galactose-1-phosphate uridylyltransferase GO012_RS07760 ENOG4105CMR udp-glucose 4-epimerase GO012_RS07765 ENOG4105DKW ABC transporter GO012_RS07770 ENOG4105F4R Transcriptional regulator mode GO012_RS07775 ENOG410680R Protein of unknown function (DUF2592) GO012_RS07780 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein GO012_RS07785 ENOG4105E0C molybdate abc transporter GO012_RS07790 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) GO012_RS07795 ENOG4108K4B hydrolase GO012_RS07800 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) GO012_RS07815 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component GO012_RS07820 ENOG4105BZU Histidine kinase GO012_RS07825 ENOG4108XDN Transcriptional regulator GO012_RS07855 ENOG4105ENT Efflux transporter rnd family, mfp subunit GO012_RS07860 ENOG4108U51 Universal stress protein GO012_RS07870 ENOG4105NBR Pectinesterase GO012_RS07875 ENOG4105CI2 imidazolone-5-propionate hydrolase GO012_RS07880 ENOG41088SP formiminoglutamate hydrolase GO012_RS07890 ENOG4105CGP Urocanate hydratase GO012_RS07895 ENOG4105C84 Histidine ammonia-lyase GO012_RS07900 ENOG4105C85 amino acid GO012_RS07905 ENOG4108V1U phospholipid-binding protein GO012_RS07910 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GO012_RS07915 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) GO012_RS07920 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GO012_RS07925 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GO012_RS07935 ENOG4108IV0 ABC, transporter GO012_RS07945 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) GO012_RS07955 ENOG4105ECM Sensor protein basS pmrB GO012_RS07960 ENOG4105XJC Two component transcriptional regulator (Winged helix family GO012_RS07965 ENOG4105DIJ Phosphoethanolamine transferase GO012_RS07970 ENOG4105CHW UPF0052 protein GO012_RS07975 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GO012_RS07980 ENOG4108RIR Molybdenum cofactor biosynthesis protein GO012_RS07985 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GO012_RS07990 ENOG4105M00 molybdopterin converting factor, subunit 1 GO012_RS07995 ENOG4108ZAF Molybdopterin GO012_RS08000 ENOG4105HFZ Membrane GO012_RS08005 ENOG4107UXM Membrane GO012_RS08010 ENOG4105DZQ phospholipase D Transphosphatidylase GO012_RS08015 ENOG4105X23 Endonuclease Exonuclease phosphatase GO012_RS08020 ENOG4105I9U inner membrane protein ybhQ GO012_RS08025 ENOG4107QWP ABC-2 type transporter GO012_RS08030 ENOG4107QWP ABC-2 type transporter GO012_RS08035 ENOG4105CJ1 ABC, transporter GO012_RS08040 ENOG4105D0S secretion protein (HlyD GO012_RS08045 ENOG4107MVR Transcriptional regulator GO012_RS08050 ENOG4108PZW LysR family Transcriptional regulator GO012_RS08055 ENOG4105DJB Major Facilitator Superfamily GO012_RS08075 ENOG4105C1J atp-dependent rna helicase GO012_RS08080 ENOG4105DVT helicase GO012_RS08085 ENOG4108MTB glycosyl transferase family GO012_RS08090 ENOG4105VR4 UPF0379 protein ybiJ GO012_RS08095 ENOG4105KSC Transcriptional regulator, TraR DksA family GO012_RS08105 ENOG4105EW6 flavin reductase domain protein, FMN-binding GO012_RS08110 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) GO012_RS08115 ENOG4105D8X mechanosensitive ion channel GO012_RS08120 ENOG4105CDA abc transporter atp-binding protein GO012_RS08125 ENOG4105E5Q amino acid AbC transporter GO012_RS08130 ENOG4107R0W ABC transporter GO012_RS08145 ENOG4108T1M outer membrane protein x GO012_RS08150 ENOG4108I6E Sulfatase GO012_RS08160 ENOG4105KST dependent repressor GO012_RS08165 ENOG4105F4P )-transporter GO012_RS08170 ENOG4105CS2 ec 3.2.1.21 GO012_RS08175 ENOG4108TZY GntR Family Transcriptional Regulator GO012_RS08180 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GO012_RS08185 ENOG4105M2Z protein tyrosine serine phosphatase GO012_RS08190 ENOG4105C5H ABC transporter GO012_RS08200 ENOG4105DPW Major facilitator superfamily MFS_1 GO012_RS08205 ENOG4105ETE Transcriptional regulator (LacI family GO012_RS08210 ENOG41072TH Protein of unknown function (DUF1479) GO012_RS08215 ENOG4108HCJ Hydrolase GO012_RS08220 ENOG4105C6N Formate acetyltransferase GO012_RS08225 ENOG4105F1A Pyruvate formate-lyase GO012_RS08230 ENOG4105D06 uba thif-type nad fad binding protein GO012_RS08235 ENOG4105CVM Molybdenum cofactor synthesis domain protein GO012_RS08240 ENOG4105D44 asparaginase GO012_RS08245 ENOG4108JQ6 ABC transporter GO012_RS08250 ENOG4105DEF Extracellular solute-binding protein, family 5 GO012_RS08255 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GO012_RS08260 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GO012_RS08265 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) GO012_RS08270 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) GO012_RS08275 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway GO012_RS08280 ENOG4105D8V Glucose sorbosone dehydrogenase GO012_RS08285 ENOG4108TGY Glutathione S-transferase GO012_RS08290 ENOG4105DZ1 carboxypeptidase GO012_RS08295 ENOG4107FB0 transcriptional regulator DeoR family GO012_RS08300 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase GO012_RS08305 ENOG4107QF7 multi-drug GO012_RS08310 ENOG4108HCJ Hydrolase GO012_RS08315 ENOG4106UW1 Major Facilitator superfamily GO012_RS08320 ENOG4108RFG Tetr family transcriptional regulator GO012_RS08330 ENOG4105GWF inner membrane protein YbjM GO012_RS08335 ENOG41090BQ Glutaredoxin GO012_RS08340 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress GO012_RS08345 ENOG4108DBC nitroreductase GO012_RS08355 ENOG4108RMJ sensory transduction regulator GO012_RS08360 ENOG4107RUE extracellular solute-binding protein family 1 GO012_RS08365 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GO012_RS08370 ENOG4105F38 ABC transporter, permease GO012_RS08375 ENOG4105D38 putrescine abc transporter GO012_RS08380 ENOG4105RBQ inner membrane protein ybjO GO012_RS08385 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) GO012_RS08390 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GO012_RS08395 ENOG4105BZU Histidine kinase GO012_RS08400 ENOG4106TNF Periplasmic binding protein GO012_RS08405 ENOG4105DMR ABC, transporter GO012_RS08410 ENOG4105GBT ABC transporter GO012_RS08415 ENOG4106PMH Extracellular solute-binding protein family 3 GO012_RS08420 ENOG4105E5Z arginine transporter ATP-binding subunit GO012_RS08425 ENOG41064MM (LipO)protein GO012_RS08435 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase GO012_RS08440 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase GO012_RS08445 ENOG4105CGD Nad-dependent epimerase dehydratase GO012_RS08450 ENOG4105C5W Aldolase GO012_RS08455 ENOG4105C7K acetolactate synthase GO012_RS08465 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GO012_RS08475 ENOG4105DWU Membrane GO012_RS08480 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GO012_RS08485 ENOG4105CPB ATP-dependent endonuclease of the OLD family GO012_RS08490 ENOG4105DJY efflux transporter, rnd family, mfp subunit GO012_RS08500 ENOG4105VEQ Cold shock protein GO012_RS08510 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GO012_RS08515 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) GO012_RS08520 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) GO012_RS08525 ENOG4108JJ8 (ABC) transporter GO012_RS08530 ENOG4108JJ9 ABC, transporter GO012_RS08535 ENOG4105C3M thioredoxin reductase GO012_RS08540 ENOG4105EW9 transcriptional regulator AsnC family GO012_RS08545 ENOG4105CNU cell division protein FtsK GO012_RS08550 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) GO012_RS08555 ENOG4105D1H recombination factor protein RarA GO012_RS08560 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) GO012_RS08565 ENOG4107QY8 reductase GO012_RS08570 ENOG4105QAX Iron-sulfur GO012_RS08575 ENOG4107KGK dmso reductase anchor subunit GO012_RS08585 ENOG4108ISG Major Facilitator GO012_RS08590 ENOG4105F1A Pyruvate formate-lyase GO012_RS08595 ENOG4105C6N Formate acetyltransferase GO012_RS08600 ENOG4105TMB Formate nitrite transporter GO012_RS08605 ENOG4105DDY UPF0142 protein ycaO GO012_RS08610 ENOG4107VMU Membrane GO012_RS08615 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) GO012_RS08620 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase GO012_RS08625 ENOG4105CAT Cytidine monophosphate kinase GO012_RS08630 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) GO012_RS08635 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) GO012_RS08640 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 GO012_RS08645 ENOG4105BZ1 (ABC) transporter GO012_RS08650 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) GO012_RS08655 ENOG4105T0Z Conserved Protein GO012_RS08660 ENOG4105W49 UPF0434 protein GO012_RS08665 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) GO012_RS08670 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups GO012_RS08675 ENOG4107S90 membrAne GO012_RS08680 ENOG4106371 Methyltransferase GO012_RS08685 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) GO012_RS08690 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) GO012_RS08695 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) GO012_RS08700 ENOG4105DIT ErfK YbiS YcfS YnhG family protein GO012_RS08705 ENOG4105EAQ (twin-arginine translocation) pathway signal GO012_RS08710 ENOG4105C5X domain protein GO012_RS08715 ENOG4105CGF Aromatic amino acid aminotransferase GO012_RS08720 ENOG4105ZIT Porin Gram-negative type GO012_RS08725 ENOG4105C5S asparaginyl-tRNA synthetase GO012_RS08735 ENOG4107RCH Diaminopropionate ammonia-lyase GO012_RS08740 ENOG4105C44 Serine transporter GO012_RS08745 ENOG4105CE7 Amidase, hydantoinase carbamoylase family GO012_RS08750 ENOG4105CH2 amidohydrolase GO012_RS08755 ENOG4107RH7 Nicotinate phosphoribosyltransferase GO012_RS08760 ENOG4105CD8 aminopeptidase N GO012_RS08770 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GO012_RS08775 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GO012_RS08780 ENOG4105GVF (ABC) transporter GO012_RS08785 ENOG4108UZX fmn reductase GO012_RS08795 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) GO012_RS08800 ENOG4105QVC MOSC domain-containing protein GO012_RS08805 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) GO012_RS08810 ENOG4105C5H ABC transporter GO012_RS08815 ENOG4105F1S paraquat-inducible protein a GO012_RS08820 ENOG4105DY2 Paraquat-inducible protein b GO012_RS08825 ENOG4108Q2G (LipO)protein GO012_RS08830 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) GO012_RS08835 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) GO012_RS08840 ENOG4105DAN ATP-dependent protease GO012_RS08845 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) GO012_RS08850 ENOG4105UYK outer membrane protein a GO012_RS08855 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) GO012_RS08865 ENOG4108RZ1 DNA transformation protein GO012_RS08870 ENOG4105EM2 membrane GO012_RS08875 ENOG410901E Membrane GO012_RS08880 ENOG41088T4 Helicase IV GO012_RS08890 ENOG4105K4P CoA-binding domain protein GO012_RS08900 ENOG4105DR4 Methyltransferase GO012_RS08905 ENOG4108V1U phospholipid-binding protein GO012_RS08910 ENOG4108UQN AraC family transcriptional regulator GO012_RS08915 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 GO012_RS08925 ENOG4108MN8 Membrane GO012_RS08930 ENOG4107QSI ABC, transporter GO012_RS08945 ENOG41082AN stage II sporulation protein GO012_RS08950 ENOG4105BZU Histidine kinase GO012_RS08970 ENOG4105BZU Histidine kinase GO012_RS08975 ENOG4106R3P AraC family transcriptional regulator GO012_RS08985 ENOG4108XCZ PTS System GO012_RS08990 ENOG4108AHH pyruvate formate lyase II activase GO012_RS08995 ENOG4105C6N Formate acetyltransferase GO012_RS09000 ENOG4108YRF PTS System GO012_RS09005 ENOG4105DM4 PTS System GO012_RS09010 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GO012_RS09015 ENOG4105E3J oxidoreductase GO012_RS09020 ENOG4105C26 Dehydrogenase GO012_RS09025 ENOG4105DVW rieske (2Fe-2S) GO012_RS09030 ENOG4105C94 Transporter GO012_RS09035 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GO012_RS09040 ENOG4105EJC lysr family transcriptional regulator GO012_RS09045 ENOG4105CJP fad dependent oxidoreductase GO012_RS09050 ENOG4105C26 Dehydrogenase GO012_RS09055 ENOG4107VRI Transcriptional regulator GO012_RS09060 ENOG4108Z86 Glutamine amidotransferase GO012_RS09065 ENOG4105CFQ glutamine synthetase GO012_RS09070 ENOG4105CUB amino acid GO012_RS09085 ENOG4105CHR reductase GO012_RS09090 ENOG4107YPT transcriptional regulator GO012_RS09095 ENOG4105D6F Phosphatase GO012_RS09100 ENOG4105XH3 GO012_RS09110 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 GO012_RS09120 ENOG4105C2W permease GO012_RS09125 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) GO012_RS09130 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) GO012_RS09135 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) GO012_RS09140 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) GO012_RS09145 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) GO012_RS09150 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) GO012_RS09155 ENOG4108R86 Transcriptional regulator GO012_RS09165 ENOG4105C26 Dehydrogenase GO012_RS09170 ENOG4105CK7 Sodium proline symporter GO012_RS09180 ENOG4105D9N nucleoside GO012_RS09185 ENOG4105EKT )-iron permease GO012_RS09190 ENOG410650H (LipO)protein GO012_RS09195 ENOG4105DBE peroxidase GO012_RS09200 ENOG4105D5M phosphate starvation-inducible protein GO012_RS09215 ENOG4105CHJ isochorismatase hydrolase GO012_RS09220 ENOG4105EUB pirin domain protein GO012_RS09225 ENOG4105HEI LysR family (Transcriptional regulator GO012_RS09235 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase GO012_RS09245 ENOG4107XHZ cytoplasmic chaperone TorD family protein GO012_RS09250 ENOG4108UQ5 membrane protein YcdZ GO012_RS09265 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) GO012_RS09275 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) GO012_RS09280 ENOG4105NAC (LipO)protein GO012_RS09285 ENOG4108W47 Acidic protein msyB GO012_RS09295 ENOG4105D1S lipid A biosynthesis GO012_RS09305 ENOG4106974 biofilm formation GO012_RS09315 ENOG4105PVA Biofilm formation regulatory protein BssS GO012_RS09320 ENOG4105MEA DNA damage-inducible protein i GO012_RS09325 ENOG4105EKE dihydroorotase GO012_RS09330 ENOG4105F3T (LipO)protein GO012_RS09335 ENOG4105EV4 Multidrug resistance protein mdtH GO012_RS09340 ENOG4105D9U N-acetyltransferase GO012_RS09345 ENOG4108YXG UPF0502 protein GO012_RS09350 ENOG4105EP9 oxidoreductase GO012_RS09355 ENOG4105CJR Integral membrane protein (MviN GO012_RS09360 ENOG4105EQ0 Major Facilitator superfamily GO012_RS09365 ENOG4105CR8 Transcriptional regulator GO012_RS09370 ENOG4107QQB Ribonuclease E GO012_RS09375 ENOG4105EI2 Pseudouridine synthase GO012_RS09380 ENOG4108UHJ MAF-like protein GO012_RS09385 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein GO012_RS09395 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) GO012_RS09400 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GO012_RS09405 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GO012_RS09410 ENOG4105CHR reductase GO012_RS09415 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GO012_RS09420 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GO012_RS09425 ENOG4105YAZ 4-amino-4-deoxychorismate lyase GO012_RS09430 ENOG4105HHA aminodeoxychorismate lyase GO012_RS09435 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) GO012_RS09440 ENOG4107QRG dna polymerase iii GO012_RS09445 ENOG4105F8V Hydrolase, tatD family GO012_RS09450 ENOG4105CI1 PTS System GO012_RS09455 ENOG4105K59 histidine triad (HIT) protein GO012_RS09460 ENOG41090DQ Lipoprotein GO012_RS09465 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) GO012_RS09480 ENOG4105D0Y UPF0227 protein GO012_RS09485 ENOG4105CEP NADH dehydrogenase GO012_RS09490 ENOG4107MBR 17 kDa surface antigen GO012_RS09500 ENOG4108IND Tetr family transcriptional regulator GO012_RS09505 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction GO012_RS09510 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GO012_RS09515 ENOG4108JA2 transcriptioN-repair coupling factor GO012_RS09520 ENOG4105D60 lipoprotein releasing system transmembrane protein GO012_RS09525 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GO012_RS09530 ENOG4105D60 lipoprotein releasing system transmembrane protein GO012_RS09535 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) GO012_RS09540 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) GO012_RS09550 ENOG4105DKT Transcriptional regulator GO012_RS09565 ENOG4105G63 Type III effector Hrp-dependent GO012_RS09570 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) GO012_RS09575 ENOG4105VI0 Pts system, glucitol sorbitol-specific GO012_RS09580 ENOG4108YZG isomerase GO012_RS09585 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GO012_RS09590 ENOG4105CV1 Transketolase (EC 2.2.1.1) GO012_RS09595 ENOG4105CEY Amp-dependent synthetase and ligase GO012_RS09605 ENOG4107RUE extracellular solute-binding protein family 1 GO012_RS09610 ENOG4105D38 putrescine abc transporter GO012_RS09615 ENOG4105F38 ABC transporter, permease GO012_RS09630 ENOG4108UK5 Transposase GO012_RS09635 ENOG4105EZE Cupin 4 family protein GO012_RS09640 ENOG4105IFJ Histidine kinase GO012_RS09660 ENOG4107QTF adenylosuccinate lyase GO012_RS09670 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) GO012_RS09685 ENOG4108HMX isocitrate dehydrogenase (NADP) GO012_RS09690 ENOG4108I1J Integrase GO012_RS09695 ENOG4105QYW Excisionase-like protein from lambdoid prophage 14 GO012_RS09700 ENOG41076J9 exonuclease VIII GO012_RS09745 ENOG4105BZU Histidine kinase GO012_RS09755 ENOG4105EKQ RNA-directed DNA polymerase GO012_RS09775 ENOG4108MXB Protein of unknown function (DUF968) GO012_RS09795 ENOG4105QFS Lysis protein S homolog from lambdoid prophage GO012_RS09800 ENOG4105KUS lysozyme GO012_RS09840 ENOG4105CAR Terminase, large subunit GO012_RS09855 ENOG4105D07 Signal peptide peptidase, SppA GO012_RS09940 ENOG4105BZU Histidine kinase GO012_RS09945 ENOG4105BZU Histidine kinase GO012_RS09950 ENOG4108HMX isocitrate dehydrogenase (NADP) GO012_RS09955 ENOG4108ZHR arsR family transcriptional regulator GO012_RS09970 ENOG4105XDF Protein of unknown function (DUF1272) GO012_RS09975 ENOG4105E2A Dehydrogenase GO012_RS09990 ENOG4108Z9Z response to DNA damage stimulus GO012_RS09995 ENOG4108N8X transition metal ion binding GO012_RS10000 ENOG4105WEF catalase GO012_RS10005 ENOG4105C4M (Ubiquinol oxidase) subunit I GO012_RS10010 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GO012_RS10035 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) GO012_RS10040 ENOG4107RSM transcriptional regulator GO012_RS10045 ENOG4106TD9 Diguanylate cyclase GO012_RS10050 ENOG4105DHT Metal Dependent Phosphohydrolase GO012_RS10060 ENOG4105D1S lipid A biosynthesis GO012_RS10065 ENOG4108NIW Leucine export protein LeuE GO012_RS10070 ENOG4105S5I Membrane GO012_RS10085 ENOG4106G4W GO012_RS10090 ENOG410620I Diguanylate cyclase GO012_RS10095 ENOG4105UCG Domain of unknown function (DUF333) GO012_RS10100 ENOG4105K78 MarR family Transcriptional regulator GO012_RS10105 ENOG4105EWC Purine nucleoside phosphorylase GO012_RS10110 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GO012_RS10115 ENOG4105DJ2 Major Facilitator Superfamily GO012_RS10120 ENOG4105R1U AraC Family Transcriptional Regulator GO012_RS10125 ENOG4108VMM UPF0756 membrane protein GO012_RS10130 ENOG4108KXH Ybak prolyl-tRNA synthetase associated GO012_RS10135 ENOG4108XNZ glycosyl transferase GO012_RS10140 ENOG4105Y50 Virulence Protein GO012_RS10145 ENOG4105EKQ RNA-directed DNA polymerase GO012_RS10150 ENOG4105KT5 UmuD protein GO012_RS10155 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GO012_RS10160 ENOG4105CBN LysR family transcriptional regulator GO012_RS10165 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr GO012_RS10170 ENOG4105F27 Major Facilitator GO012_RS10195 ENOG4106AKX UPF0229 protein GO012_RS10200 ENOG4105CYN Serine protein kinase GO012_RS10205 ENOG4105GNX MltA-interacting MipA family protein GO012_RS10210 ENOG4105CV8 reductase GO012_RS10215 ENOG4105DSB aldose 1-epimerase GO012_RS10220 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GO012_RS10225 ENOG4105E0X reductase GO012_RS10230 ENOG4105VUT cytoplasmic protein GO012_RS10235 ENOG4105N1F Hnh endonuclease GO012_RS10245 ENOG4108RWI nicotinamidase GO012_RS10250 ENOG4105HDK L-asparaginase GO012_RS10255 ENOG4105D07 Signal peptide peptidase, SppA GO012_RS10260 ENOG41069NU Nitroreductase GO012_RS10265 ENOG4105SBG acid phosphatase GO012_RS10270 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) GO012_RS10275 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GO012_RS10285 ENOG4105D82 Glutamate dehydrogenase GO012_RS10290 ENOG4105M6F mutator MutT protein GO012_RS10295 ENOG4108T9J Cdp-alcohol phosphatidyltransferase GO012_RS10300 ENOG4107RM6 sulfurtransferase GO012_RS10305 ENOG4108VGW abc transporter atp-binding protein GO012_RS10310 ENOG4105CXZ ABC transporter, permease GO012_RS10315 ENOG4105VNH ABC transporter solute-binding protein GO012_RS10320 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GO012_RS10325 ENOG4108N5C SNARE associated Golgi protein-related protein GO012_RS10330 ENOG4108RSN SNARE associated Golgi GO012_RS10335 ENOG4105CGK Exodeoxyribonuclease III GO012_RS10345 ENOG4105F4X arginine GO012_RS10350 ENOG4105C26 Dehydrogenase GO012_RS10355 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) GO012_RS10365 ENOG4108SPG Periplasmic Protein GO012_RS10370 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) GO012_RS10380 ENOG4105KKI DNA-binding transcriptional activator OsmE GO012_RS10385 ENOG4105VZJ PTS System GO012_RS10390 ENOG4105CK1 PTS System GO012_RS10395 ENOG4105VCP PTS System GO012_RS10400 ENOG4105EZV Transcriptional regulator GO012_RS10405 ENOG4105F8D glycoside hydrolase family 4 GO012_RS10410 ENOG410901P UPF0249 protein GO012_RS10415 ENOG4105CH6 catalase GO012_RS10420 ENOG4105R8J Activates the cell division inhibited by chromosomal DNA over-replication (By similarity) GO012_RS10425 ENOG4108ETY sodium dicarboxylate symporter GO012_RS10430 ENOG4107K5X Membrane-bound metal-dependent hydrolase GO012_RS10435 ENOG4105CHR reductase GO012_RS10440 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 GO012_RS10445 ENOG4107PN8 YfeABCD locus regulator GO012_RS10450 ENOG4105NAU thioesterase Superfamily protein GO012_RS10455 ENOG4107RNH Outer membrane receptor FepA GO012_RS10460 ENOG4107835 probably involved in intracellular septation (By similarity) GO012_RS10465 ENOG4108S3I UPF0259 membrane protein GO012_RS10470 ENOG4105PI0 Ferredoxin GO012_RS10475 ENOG4105EIF outer membrane protein W GO012_RS10480 ENOG4107E2E PKHD-type hydroxylase GO012_RS10485 ENOG4108IU3 tonb-dependent siderophore receptor GO012_RS10535 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) GO012_RS10540 ENOG4105DK0 Indole-3-glycerol phosphate synthase GO012_RS10545 ENOG4108EFP Anthranilate synthase component II GO012_RS10550 ENOG4105CRQ synthase (Component I) GO012_RS10555 ENOG4105DB7 PHP domain protein GO012_RS10560 ENOG4107RTD sua5 ycio yrdc ywlc family protein GO012_RS10570 ENOG4105ETT transcriptional Regulator, LysR family GO012_RS10575 ENOG4105FE9 pseudouridine synthase GO012_RS10580 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase GO012_RS10585 ENOG4105UBK short-chain dehydrogenase reductase GO012_RS10595 ENOG4105ERU peptidase GO012_RS10600 ENOG4105RKX Protein of unknown function (DUF2498) GO012_RS10605 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GO012_RS10610 ENOG4107R11 Transcriptional regulator GO012_RS10620 ENOG4107QM5 aconitate hydratase GO012_RS10625 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) GO012_RS10630 ENOG4105EYK Phosphatidylglycerophosphatase B GO012_RS10635 ENOG4105Q4A inner membrane protein yciS GO012_RS10640 ENOG4105CFV Tetratricopeptide repeat protein GO012_RS10650 ENOG4108ZJT translation initiation factor, Sui1 GO012_RS10655 ENOG41061RM osmotically inducible lipoprotein GO012_RS10660 ENOG4105N2W Transcriptional regulator GO012_RS10670 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) GO012_RS10675 ENOG4105Q4T oxidoreductase GO012_RS10680 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH GO012_RS10690 ENOG4105ETS cytosine purines uracil thiamine allantoin GO012_RS10695 ENOG4108JQ2 peptide transport system atp-binding protein GO012_RS10700 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein GO012_RS10705 ENOG4108EU3 peptide transport system, permease GO012_RS10710 ENOG4108I5W peptide transport system, permease protein GO012_RS10715 ENOG4108J59 Extracellular solute-binding protein, family 5 GO012_RS10730 ENOG41063ZK Transcriptional Regulator AraC Family GO012_RS10735 ENOG4105CH2 amidohydrolase GO012_RS10745 ENOG4105E51 psp operon transcriptional activator GO012_RS10750 ENOG41087YS Phage shock protein A GO012_RS10755 ENOG4105YYT phage shock protein B GO012_RS10760 ENOG4105FM1 phage shock protein C GO012_RS10765 ENOG4105NNG Peripheral inner membrane phage-shock protein GO012_RS10770 ENOG4105CM6 amino acid regulated cytosolic protein GO012_RS10775 ENOG4106K28 UPF0283 membrane protein GO012_RS10780 ENOG4105W8I Transcriptional regulator GO012_RS10785 ENOG4105F8D glycoside hydrolase family 4 GO012_RS10790 ENOG4108JU8 Transcriptional regulator GO012_RS10795 ENOG4108KK1 membrane protein AbrB duplication GO012_RS10800 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) GO012_RS10805 ENOG4107S8C mandelate racemase muconate lactonizing GO012_RS10810 ENOG4105KXI murein peptide amidase A GO012_RS10815 ENOG4107QSI ABC, transporter GO012_RS10865 ENOG4105EQ2 LysR family Transcriptional regulator GO012_RS10870 ENOG4105ENX hydrolase GO012_RS10875 ENOG4107RTG Major Facilitator superfamily GO012_RS10890 ENOG4105BZU Histidine kinase GO012_RS10915 ENOG4107QZ7 Cellulose synthase catalytic subunit GO012_RS10930 ENOG4105BZU Histidine kinase GO012_RS10950 ENOG4105CBN LysR family transcriptional regulator GO012_RS10965 ENOG4108Z0Z intracellular protease Pfpi family GO012_RS10990 ENOG4108ZG0 Ompa motb domain protein GO012_RS11000 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GO012_RS11015 ENOG4107X35 defense response to bacterium GO012_RS11085 ENOG4105F6U Short-chain dehydrogenase reductase Sdr GO012_RS11090 ENOG4108XFH Transcriptional regulator GO012_RS11115 ENOG4105HEI LysR family (Transcriptional regulator GO012_RS11140 ENOG4105EE1 crotonyl-CoA reductase GO012_RS11150 ENOG4105D01 (LipO)protein GO012_RS11160 ENOG4108UMI ABC transporter, permease GO012_RS11165 ENOG4105CGF Aromatic amino acid aminotransferase GO012_RS11175 ENOG4105F7P transcriptional regulator AsnC family GO012_RS11180 ENOG4105C85 amino acid GO012_RS11195 ENOG4105D9R oxidoreductase GO012_RS11200 ENOG4105E98 transcriptional regulator DeoR family GO012_RS11205 ENOG4107RX3 Mg2 transporter protein cora family protein GO012_RS11210 ENOG4105C1J atp-dependent rna helicase GO012_RS11220 ENOG4108RW8 Universal stress protein F GO012_RS11230 ENOG4105FCK Membrane GO012_RS11235 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) GO012_RS11245 ENOG41090X5 Heat shock protein hslJ GO012_RS11250 ENOG4105C5I Dehydrogenase GO012_RS11255 ENOG4108KF1 Membrane GO012_RS11260 ENOG4107H52 Dicarboxylate transport GO012_RS11265 ENOG410689M (LipO)protein GO012_RS11270 ENOG4105WXT Conserved Protein GO012_RS11275 ENOG4108WFR AraC Family Transcriptional Regulator GO012_RS11280 ENOG4105C26 Dehydrogenase GO012_RS11295 ENOG4105F11 amine oxidase GO012_RS11300 ENOG4105DXM phenylacetic acid degradation protein GO012_RS11305 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit GO012_RS11310 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit GO012_RS11315 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit GO012_RS11320 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit GO012_RS11325 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GO012_RS11330 ENOG4105E39 Enoyl-CoA hydratase GO012_RS11335 ENOG4108UKI Enoyl-CoA hydratase GO012_RS11340 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GO012_RS11345 ENOG4108ZJI phenylacetic acid degradation protein GO012_RS11350 ENOG4105CHU acetyl-coa acetyltransferase GO012_RS11355 ENOG4105DZS Phenylacetate-CoA ligase GO012_RS11360 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein GO012_RS11365 ENOG4108Z0R Transferase GO012_RS11375 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GO012_RS11380 ENOG4105CQ7 ATP-dependent helicase GO012_RS11390 ENOG4105ENJ RND efflux system, outer membrane lipoprotein GO012_RS11410 ENOG410642W LysR family Transcriptional regulator GO012_RS11415 ENOG4105CPC Aldo Keto reductase GO012_RS11420 ENOG4105D82 Glutamate dehydrogenase GO012_RS11425 ENOG4105C8Y Acetylornithine aminotransferase GO012_RS11430 ENOG4105F4X arginine GO012_RS11435 ENOG4105C26 Dehydrogenase GO012_RS11440 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) GO012_RS11445 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) GO012_RS11455 ENOG4105CSH Transporter GO012_RS11460 ENOG4107DB1 DUF218 domain GO012_RS11465 ENOG4105C26 Dehydrogenase GO012_RS11470 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GO012_RS11475 ENOG4105VPI YqaE family transport protein GO012_RS11480 ENOG41064WM Uncharacterized protein YcgX GO012_RS11485 ENOG4105KSU Redox protein GO012_RS11490 ENOG41066VF YeeE YedE family protein GO012_RS11505 ENOG41061EV selenium-binding protein YdfZ GO012_RS11515 ENOG4105C87 Aminotransferase class I and II GO012_RS11520 ENOG4105CI1 PTS System GO012_RS11525 ENOG4107P2S Transcriptional regulator GO012_RS11530 ENOG4106J39 exported protein GO012_RS11535 ENOG4105EIP mannose-6-phosphate isomerase GO012_RS11540 ENOG4107GFK fumarate GO012_RS11545 ENOG4105C9Q fumarate hydratase class II GO012_RS11555 ENOG4105JJR Histidine kinase GO012_RS11565 ENOG4107EXC regulatoR GO012_RS11570 ENOG4105RA2 Membrane GO012_RS11575 ENOG410642E Short chain dehydrogenase GO012_RS11580 ENOG4105D5Q Arginine ornithine antiporter GO012_RS11585 ENOG4105C5D exported protein GO012_RS11590 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) GO012_RS11595 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) GO012_RS11600 ENOG410671Z uncharacterized protein ydiH GO012_RS11605 ENOG4105Q9Y Universal stress protein GO012_RS11610 ENOG4105DS0 Transcriptional regulator, Crp Fnr family GO012_RS11615 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GO012_RS11625 ENOG4105CFC Transporter GO012_RS11630 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B GO012_RS11640 ENOG4106KR7 LysR family Transcriptional regulator GO012_RS11645 ENOG4108DG9 Smr protein MutS2 GO012_RS11650 ENOG4107HP6 Transcriptional regulator GO012_RS11660 ENOG4107QNJ CoA-transferase subunit B GO012_RS11665 ENOG4105CHU acetyl-coa acetyltransferase GO012_RS11670 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase GO012_RS11675 ENOG4105F2Z 3-oxoadipate enol-lactonase GO012_RS11680 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase GO012_RS11690 ENOG4107GFK fumarate GO012_RS11710 ENOG4108MRH transcriptional regulatory protein GO012_RS11715 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GO012_RS11725 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GO012_RS11730 ENOG4105DWT malate dehydrogenase (quinone) GO012_RS11735 ENOG4108K70 Transcriptional regulator GO012_RS11740 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GO012_RS11745 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase GO012_RS11750 ENOG4107TT2 Auxin Efflux Carrier GO012_RS11780 ENOG4105DSF transport protein GO012_RS11785 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) GO012_RS11790 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) GO012_RS11800 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap GO012_RS11810 ENOG4105CTD carboxy-peptidase GO012_RS11815 ENOG4105D94 Major Facilitator Superfamily GO012_RS11820 ENOG4106NZI LysR family Transcriptional regulator GO012_RS11825 ENOG4105DAG ROK family GO012_RS11830 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) GO012_RS11835 ENOG4105CMQ Chloride channel GO012_RS11840 ENOG4108NEM leader-binding protein dmsD GO012_RS11845 ENOG4107KGK dmso reductase anchor subunit GO012_RS11850 ENOG4105QAX Iron-sulfur GO012_RS11855 ENOG4107QY8 reductase GO012_RS11860 ENOG4105KBG Protein of unknown function (DUF1161) GO012_RS11870 ENOG4108MK9 spermidine N(1)-acetyltransferase GO012_RS11875 ENOG4105M5Q UPF0482 protein GO012_RS11880 ENOG4105KK4 UPF0060 membrane protein GO012_RS11885 ENOG4108I5G Major Facilitator superfamily GO012_RS11890 ENOG4105DEI Mannitol dehydrogenase GO012_RS11895 ENOG4108U51 Universal stress protein GO012_RS11900 ENOG4107XBN GntR Family Transcriptional Regulator GO012_RS11905 ENOG4105EMU Dehydrogenase GO012_RS11910 ENOG4105DGW oligopeptidase A GO012_RS11920 ENOG4105R1U AraC Family Transcriptional Regulator GO012_RS11925 ENOG4108RAV Conserved protein GO012_RS11935 ENOG4108WQH regulatoR GO012_RS11940 ENOG4108ZNX Heat shock protein GO012_RS11945 ENOG4108WTK competence damage-inducible protein GO012_RS11950 ENOG4105BZU Histidine kinase GO012_RS11970 ENOG4105C6Z Gluconate GO012_RS11975 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) GO012_RS11980 ENOG4105FB2 class II Aldolase GO012_RS11985 ENOG4105G63 Type III effector Hrp-dependent GO012_RS11995 ENOG4105MVE transcriptional regulator GO012_RS12000 ENOG4108J4B Beta-lactamase GO012_RS12010 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GO012_RS12015 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) GO012_RS12020 ENOG4105CNT hydrolase family 2 GO012_RS12025 ENOG4105ETE Transcriptional regulator (LacI family GO012_RS12040 ENOG4105ECQ AraC Family Transcriptional Regulator GO012_RS12060 ENOG4105C32 Amino acid ABC transporter (Permease) GO012_RS12065 ENOG4105CNN ABC, transporter GO012_RS12070 ENOG4105C0Z ABC transporter GO012_RS12075 ENOG4108IV0 ABC, transporter GO012_RS12085 ENOG4105E5W Transporter GO012_RS12090 ENOG4108594 Permease of the drug metabolite transporter GO012_RS12095 ENOG4106DNR multiple antibiotic resistance protein GO012_RS12100 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF GO012_RS12105 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes GO012_RS12110 ENOG41082NP Multiple antibiotic resistance GO012_RS12115 ENOG4105F27 Major Facilitator GO012_RS12120 ENOG4105JAB phenazine biosynthesis protein, phzf family GO012_RS12130 ENOG4108JQ1 Dehydrogenase GO012_RS12135 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GO012_RS12140 ENOG4105C0A alcohol dehydrogenase GO012_RS12145 ENOG4107S2N Type III effector Hrp-dependent GO012_RS12150 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) GO012_RS12155 ENOG4105MVE transcriptional regulator GO012_RS12160 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GO012_RS12170 ENOG4105EGI Transcriptional regulator GO012_RS12175 ENOG4105C26 Dehydrogenase GO012_RS12180 ENOG4105CSV Glutaminase GO012_RS12185 ENOG4105M0C cytoplasmic protein GO012_RS12190 ENOG4105BZU Histidine kinase GO012_RS12200 ENOG4107QZW Altronate oxidoreductase GO012_RS12255 ENOG4105F9N Major Facilitator Superfamily GO012_RS12265 ENOG4105CBP Major Facilitator GO012_RS12270 ENOG4105EGI Transcriptional regulator GO012_RS12275 ENOG4105EA8 2-Nitropropane dioxygenase GO012_RS12280 ENOG4108UMI ABC transporter, permease GO012_RS12290 ENOG4105D01 (LipO)protein GO012_RS12315 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions GO012_RS12335 ENOG4108KSA LysR family transcriptional regulator GO012_RS12340 ENOG41061H0 Monooxygenase GO012_RS12345 ENOG4105C2W permease GO012_RS12350 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) GO012_RS12355 ENOG4105VT2 5-hydroxyisourate hydrolase GO012_RS12360 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein GO012_RS12365 ENOG4105CAF HipA N-terminal domain protein GO012_RS12370 ENOG4105F32 YngK protein GO012_RS12380 ENOG4105CW0 outer membrane usher protein GO012_RS12385 ENOG4108VCD Chaperone GO012_RS12400 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GO012_RS12415 ENOG4105BZU Histidine kinase GO012_RS12420 ENOG4105NIV Esterase GO012_RS12430 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein GO012_RS12435 ENOG4105C54 Major Facilitator superfamily GO012_RS12440 ENOG4105F8D glycoside hydrolase family 4 GO012_RS12445 ENOG4105CI1 PTS System GO012_RS12450 ENOG4107YCY Transcriptional regulator GO012_RS12460 ENOG4105JQN Transcriptional regulator GO012_RS12470 ENOG4107VHA regulatoR GO012_RS12475 ENOG4105BZW Glycerate kinase GO012_RS12495 ENOG4105CHU acetyl-coa acetyltransferase GO012_RS12500 ENOG4105CHR reductase GO012_RS12505 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) GO012_RS12520 ENOG4105EDR glucose galactose transporter GO012_RS12525 ENOG4108RVA ribokinase GO012_RS12530 ENOG4105UP7 3-epimerase GO012_RS12535 ENOG4105E98 transcriptional regulator DeoR family GO012_RS12540 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) GO012_RS12545 ENOG4105CMG Carbohydrate kinase GO012_RS12565 ENOG4105CPC Aldo Keto reductase GO012_RS12570 ENOG4105EQ2 LysR family Transcriptional regulator GO012_RS12575 ENOG4105RHY Pfam:UPF0157 GO012_RS12580 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta GO012_RS12590 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC GO012_RS12595 ENOG4105CXY transporter GO012_RS12600 ENOG4109066 lysm domain bon superfamily protein GO012_RS12630 ENOG4105ETE Transcriptional regulator (LacI family GO012_RS12635 ENOG4105C2J ABC transporter GO012_RS12640 ENOG4105CNN ABC, transporter GO012_RS12655 ENOG4107PP3 Acetylornithine deacetylase GO012_RS12670 ENOG4105HEI LysR family (Transcriptional regulator GO012_RS12675 ENOG4105CBN LysR family transcriptional regulator GO012_RS12685 ENOG410829K Lysine exporter protein (Lyse ygga) GO012_RS12690 ENOG4105DM4 PTS System GO012_RS12695 ENOG4108YRF PTS System GO012_RS12710 ENOG4105UP7 3-epimerase GO012_RS12715 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC GO012_RS12725 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia GO012_RS12730 ENOG4105ETE Transcriptional regulator (LacI family GO012_RS12740 ENOG4105FCD Major Facilitator GO012_RS12770 ENOG4105CSH Transporter GO012_RS12775 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain GO012_RS12780 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GO012_RS12790 ENOG4105CBN LysR family transcriptional regulator GO012_RS12805 ENOG4105C5R Aminotransferase GO012_RS12815 ENOG4105E5Q amino acid AbC transporter GO012_RS12835 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GO012_RS12860 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GO012_RS12880 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GO012_RS12895 ENOG4105R1U AraC Family Transcriptional Regulator GO012_RS12900 ENOG41089BK Glutamine amido-transferase GO012_RS12905 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) GO012_RS12940 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease GO012_RS12945 ENOG4107QUY Guanine deaminase GO012_RS12950 ENOG4105BZU Histidine kinase GO012_RS12955 ENOG4105ETE Transcriptional regulator (LacI family GO012_RS12965 ENOG4105CIB oxidoreductase Domain protein GO012_RS12975 ENOG4105ETU transcriptional activator (TenA GO012_RS12980 ENOG4108YI8 ABC transporter GO012_RS12985 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component GO012_RS12990 ENOG4107Z6I Thiamine biosynthesis protein GO012_RS12995 ENOG4108JPW Aminotransferase GO012_RS13000 ENOG4105DY8 decarboxylase GO012_RS13015 ENOG4105E0F Histidine kinase GO012_RS13020 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GO012_RS13025 ENOG4108J2P Alpha beta hydrolase fold GO012_RS13030 ENOG4108IGT Dipeptidase GO012_RS13040 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) GO012_RS13045 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) GO012_RS13055 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E GO012_RS13060 ENOG4107VK2 coenzyme PQQ biosynthesis protein PqqF GO012_RS13065 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GO012_RS13085 ENOG4106KR7 LysR family Transcriptional regulator GO012_RS13090 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) GO012_RS13095 ENOG4105D6Z AFG1 family ATPase GO012_RS13100 ENOG4105KT7 mgtC SapB transporter GO012_RS13105 ENOG4108KUU Inner membrane metabolite transport protein ydjE GO012_RS13110 ENOG4105VCP PTS System GO012_RS13115 ENOG4105VZJ PTS System GO012_RS13145 ENOG4107RSM transcriptional regulator GO012_RS13150 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit GO012_RS13155 ENOG4105FFC UPF0187 protein GO012_RS13160 ENOG41076HS cation diffusion facilitator family transporter GO012_RS13175 ENOG4108Z9K Osmotically inducible protein GO012_RS13180 ENOG4108YDI single-species biofilm formation on inanimate substrate GO012_RS13200 ENOG4105CG3 alpha amylase, catalytic region GO012_RS13210 ENOG4108N8X transition metal ion binding GO012_RS13225 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GO012_RS13230 ENOG4105N0E Protein of unknown function (DUF2543) GO012_RS13235 ENOG4105EQ2 LysR family Transcriptional regulator GO012_RS13250 ENOG4107R1I NAD-dependent malic enzyme GO012_RS13260 ENOG4105C5H ABC transporter GO012_RS13275 ENOG4105DQ4 alcohol dehydrogenase GO012_RS13290 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GO012_RS13295 ENOG4108JQ6 ABC transporter GO012_RS13310 ENOG4105F27 Major Facilitator GO012_RS13320 ENOG4105CSR polyphosphate kinase 2 GO012_RS13335 ENOG4108MG3 formate dehydrogenase GO012_RS13340 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein GO012_RS13365 ENOG4108UKV benzoate 1,2-dioxygenase GO012_RS13375 ENOG410626B catechol 1,2-dioxygenase GO012_RS13380 ENOG4105NN7 muconolactone delta-isomerase GO012_RS13385 ENOG4105DTQ mandelate racemase muconate lactonizing GO012_RS13390 ENOG4107HP6 Transcriptional regulator GO012_RS13405 ENOG4107QND Nitrite extrusion protein GO012_RS13410 ENOG4105CRU nitrate reductase, alpha subunit GO012_RS13415 ENOG4108IUE nitrate reductase beta subunit GO012_RS13420 ENOG4108NZN Respiratory nitrate reductase 2 delta chain GO012_RS13425 ENOG4105D0D Nitrate reductase 2, gamma subunit GO012_RS13430 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase GO012_RS13435 ENOG4107RCV ABC transporter, permease GO012_RS13440 ENOG4105C4Y ABC transporter GO012_RS13445 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GO012_RS13450 ENOG4108MEJ flavin reductase domain protein GO012_RS13455 ENOG4105KZK Tautomerase pptA GO012_RS13460 ENOG4108N27 Glutathione S-transferase GO012_RS13470 ENOG4105CDA abc transporter atp-binding protein GO012_RS13475 ENOG4105DRP amino acid AbC transporter GO012_RS13485 ENOG4105EAB amino acid AbC transporter GO012_RS13495 ENOG4105CH2 amidohydrolase GO012_RS13500 ENOG4105DEN Luciferase family GO012_RS13505 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) GO012_RS13510 ENOG4105EQ2 LysR family Transcriptional regulator GO012_RS13515 ENOG4105C85 amino acid GO012_RS13525 ENOG4108NS2 receptor GO012_RS13530 ENOG4105CHB tonB-dependent Receptor GO012_RS13535 ENOG4105CI2 imidazolone-5-propionate hydrolase GO012_RS13540 ENOG41065TG regulatoR GO012_RS13545 ENOG4105DU0 nucleoside hydrolase GO012_RS13550 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein GO012_RS13560 ENOG4108Z7F N-acetyltransferase GO012_RS13565 ENOG4108T9Y Inner membrane protein ydcZ GO012_RS13570 ENOG4105R71 cytoplasmic protein GO012_RS13575 ENOG4105DEF Extracellular solute-binding protein, family 5 GO012_RS13585 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 GO012_RS13590 ENOG410654E Membrane GO012_RS13615 ENOG4105C26 Dehydrogenase GO012_RS13620 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component GO012_RS13625 ENOG4105D81 ABC transporter, permease GO012_RS13630 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GO012_RS13635 ENOG4107TYH extracellular solute-binding protein family 1 GO012_RS13640 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GO012_RS13645 ENOG4105C4M (Ubiquinol oxidase) subunit I GO012_RS13650 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GO012_RS13670 ENOG4105CFP Peptidase U32 GO012_RS13680 ENOG4108JCI Transcriptional regulator GO012_RS13685 ENOG4105DKK Benzoate GO012_RS13690 ENOG4105UEI Transcriptional Regulator AraC Family GO012_RS13695 ENOG4108RNG Permease of the drug metabolite transporter GO012_RS13700 ENOG4108KKZ (LipO)protein GO012_RS13705 ENOG41088CC tellurite resistance protein tehB GO012_RS13710 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein GO012_RS13715 ENOG4107WE3 acetyltransferase YdcK GO012_RS13720 ENOG4108Z9I -acetyltransferase GO012_RS13735 ENOG4105EBR Carboxylesterase GO012_RS13740 ENOG4105E32 cytoplasmic protein GO012_RS13745 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta GO012_RS13750 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha GO012_RS13775 ENOG4105CPW cytochrome b561 GO012_RS13790 ENOG4107YPT transcriptional regulator GO012_RS13795 ENOG4105EQ0 Major Facilitator superfamily GO012_RS13800 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GO012_RS13805 ENOG4105D9R oxidoreductase GO012_RS13815 ENOG4105CS2 ec 3.2.1.21 GO012_RS13825 ENOG4105M9B inner membrane protein ydgK GO012_RS13850 ENOG4108UQQ Electron transport complex GO012_RS13860 ENOG4105CSM endonuclease III GO012_RS13870 ENOG4108K3A Glutathione S-transferase GO012_RS13875 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) GO012_RS13880 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GO012_RS13885 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) GO012_RS13890 ENOG410642K Lysozyme inhibitor GO012_RS13895 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) GO012_RS13900 ENOG4108XTF Outer Membrane Lipoprotein GO012_RS13905 ENOG4105BZU Histidine kinase GO012_RS13920 ENOG4105Y49 secretion protein, HlyD family GO012_RS13925 ENOG4105DSW Fusaric acid resistance protein GO012_RS13930 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GO012_RS13935 ENOG4107RGM aldo keto reductase GO012_RS13940 ENOG4105XZD Fe-S protein GO012_RS13945 ENOG4108WUH Transcriptional regulator, TetR family GO012_RS13950 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GO012_RS13955 ENOG4108UYE Lactoylglutathione lyase GO012_RS13960 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) GO012_RS13965 ENOG4105M2J Glutaredoxin GO012_RS13970 ENOG4105K4H Nlp p60 protein GO012_RS13980 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GO012_RS13985 ENOG4105F27 Major Facilitator GO012_RS13995 ENOG4105ETE Transcriptional regulator (LacI family GO012_RS14000 ENOG4105F52 Transcriptional regulator GO012_RS14005 ENOG4105CZQ inner membrane transport protein YdhC GO012_RS14010 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GO012_RS14015 ENOG4108R6K riboflavin synthase, subunit alpha GO012_RS14020 ENOG4107QI1 Mate efflux family protein GO012_RS14030 ENOG4108URH decarboxylase GO012_RS14060 ENOG4105E1F short-chain dehydrogenase reductase GO012_RS14080 ENOG4105CY0 Metallo-Beta-Lactamase GO012_RS14100 ENOG4107B2H carbonic anhydrase GO012_RS14110 ENOG4105E98 transcriptional regulator DeoR family GO012_RS14115 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase GO012_RS14145 ENOG4105C3U ABC transporter GO012_RS14150 ENOG4108JQ7 (ABC) transporter GO012_RS14195 ENOG4105EMY transcriptional regulator GO012_RS14205 ENOG4107TTD cytosine deaminase GO012_RS14210 ENOG4105KME endoribonuclease L-psp GO012_RS14235 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component GO012_RS14240 ENOG4105CQB FAD linked oxidase domain protein GO012_RS14265 ENOG4106NZI LysR family Transcriptional regulator GO012_RS14275 ENOG4107QNJ CoA-transferase subunit B GO012_RS14280 ENOG4105CHU acetyl-coa acetyltransferase GO012_RS14285 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) GO012_RS14290 ENOG4105CY2 Citrate transporter GO012_RS14295 ENOG4105DTD Dehydrogenase GO012_RS14310 ENOG4105C7K acetolactate synthase GO012_RS14315 ENOG4105CHR reductase GO012_RS14340 ENOG4108M1T Cytochrome c-type biogenesis protein GO012_RS14345 ENOG4105KWW Biogenesis protein GO012_RS14350 ENOG4107QX9 Thiol disulfide interChange protein GO012_RS14355 ENOG4105DA4 cytochrome c-type biogenesis protein GO012_RS14370 ENOG41060IM Heme exporter protein GO012_RS14375 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) GO012_RS14380 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) GO012_RS14410 ENOG4105GMB type VI secretion system effector, hcp1 family GO012_RS14415 ENOG4105PWE CRISPR-associated protein cas2 GO012_RS14420 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) GO012_RS14430 ENOG41060M0 Crispr-associated protein, cse4 family GO012_RS14460 ENOG4107Z33 ABC transporter, permease GO012_RS14465 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC GO012_RS14470 ENOG4105DG4 malate L-lactate dehydrogenase GO012_RS14475 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GO012_RS14480 ENOG4105CH2 amidohydrolase GO012_RS14495 ENOG41083G8 Multidrug resistance protein MdtM GO012_RS14510 ENOG4105CDA abc transporter atp-binding protein GO012_RS14515 ENOG4105E5Q amino acid AbC transporter GO012_RS14520 ENOG4106PMH Extracellular solute-binding protein family 3 GO012_RS14540 ENOG4105DQ5 transport system permease protein GO012_RS14545 ENOG4105E0A ABC, transporter GO012_RS14555 ENOG4108IY8 ABC, transporter GO012_RS14560 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GO012_RS14580 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GO012_RS14585 ENOG4106KR7 LysR family Transcriptional regulator GO012_RS14590 ENOG4108T2C cysteine dioxygenase type I GO012_RS14605 ENOG4108SC4 )-transporter GO012_RS14610 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) GO012_RS14615 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) GO012_RS14620 ENOG4105IKQ hydratase GO012_RS14625 ENOG4107UB2 Alpha beta hydrolase fold GO012_RS14630 ENOG4105MI0 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively (By similarity) GO012_RS14635 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase GO012_RS14640 ENOG4108K2P TRANSCRIPTIONal GO012_RS14645 ENOG4105S10 periplasmic binding protein GO012_RS14650 ENOG4105EHG Permease protein GO012_RS14655 ENOG4108W0P ABC transporter GO012_RS14660 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein GO012_RS14665 ENOG4105E2X shikimate dehydrogenase GO012_RS14670 ENOG4105DJB Major Facilitator Superfamily GO012_RS14685 ENOG4105RFR Protein of unknown function (DUF2767) GO012_RS14695 ENOG4105CA9 Pyruvate kinase GO012_RS14705 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GO012_RS14710 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) GO012_RS14715 ENOG4105C9B Cysteine desulfurase GO012_RS14720 ENOG4105JRK feS assembly protein SufD GO012_RS14725 ENOG4105C3K feS assembly ATPase SufC GO012_RS14730 ENOG4105DIW FeS assembly protein SUFB GO012_RS14735 ENOG4108Z4V iron-sulfur cluster assembly GO012_RS14750 ENOG4105KBX Transcriptional regulator, TetR family GO012_RS14755 ENOG4105DMF Dehydrogenase GO012_RS14780 ENOG4106KR7 LysR family Transcriptional regulator GO012_RS14790 ENOG4105EHG Permease protein GO012_RS14795 ENOG4105E0A ABC, transporter GO012_RS14805 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) GO012_RS14820 ENOG4105Y3U Transglycosylase-associated protein GO012_RS14825 ENOG4105KA0 thioesterase Superfamily protein GO012_RS14830 ENOG4105CQB FAD linked oxidase domain protein GO012_RS14835 ENOG4105IPI Membrane GO012_RS14845 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GO012_RS14855 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GO012_RS14860 ENOG4106EDX Hemin uptake protein GO012_RS14865 ENOG4105CNG UPF0061 protein GO012_RS14870 ENOG4108QBX (LipO)protein GO012_RS14880 ENOG4108V06 Glutathione peroxidase GO012_RS14885 ENOG4105D01 (LipO)protein GO012_RS14890 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) GO012_RS14900 ENOG4105RQF LysR family Transcriptional regulator GO012_RS14905 ENOG4105MWK D-amino acid dehydrogenase, small subunit GO012_RS14920 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GO012_RS14925 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) GO012_RS14935 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) GO012_RS14940 ENOG41082NX 50s ribosomal protein l35 GO012_RS14945 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) GO012_RS14960 ENOG4108NE3 Salt-induced outer membrane protein GO012_RS14965 ENOG4105DE4 1-phosphofructokinase GO012_RS14970 ENOG4105P10 Uncharacterized protein ydiZ GO012_RS14975 ENOG4105FGM Fructosamine kinase GO012_RS14980 ENOG410822N TonB family GO012_RS14985 ENOG4105K9H YciI-like protein GO012_RS14990 ENOG4108YYC ycei family GO012_RS15000 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GO012_RS15010 ENOG4105EYW Ion transport protein GO012_RS15015 ENOG4108JQ7 (ABC) transporter GO012_RS15020 ENOG4105C3U ABC transporter GO012_RS15025 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GO012_RS15035 ENOG4108J59 Extracellular solute-binding protein, family 5 GO012_RS15040 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein GO012_RS15045 ENOG4108EKI Dehydrogenase GO012_RS15050 ENOG4107104 thymidine kinase GO012_RS15060 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GO012_RS15065 ENOG4105I93 response regulator GO012_RS15070 ENOG4105D78 K07001 NTE family protein GO012_RS15080 ENOG4105CIY formyltetrahydrofolate deformylase GO012_RS15125 ENOG41076YT nitrate reductase, gamma subunit GO012_RS15130 ENOG4105R3A Nitrate reductase GO012_RS15135 ENOG4108IUE nitrate reductase beta subunit GO012_RS15140 ENOG4105CRU nitrate reductase, alpha subunit GO012_RS15145 ENOG4105DQQ Major facilitator superfamily MFS_1 GO012_RS15150 ENOG4105BZU Histidine kinase GO012_RS15155 ENOG4105WH1 Two component transcriptional regulator luxr family GO012_RS15160 ENOG4105ID0 Putative invasin GO012_RS15170 ENOG4107QZF nitrite reductase NADPH large subunit GO012_RS15175 ENOG4105D7T ABC transporter GO012_RS15185 ENOG4105I5W Transporter GO012_RS15195 ENOG41090EX DsrE family GO012_RS15205 ENOG4108NH8 Cation transport protein GO012_RS15210 ENOG4105WS7 Cation transport regulator GO012_RS15215 ENOG4105EWV Sodium calcium exchanger membrane region GO012_RS15225 ENOG41063JG Transcriptional regulator GO012_RS15230 ENOG4108YY7 Invasion gene expression up-regulator SirB GO012_RS15235 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GO012_RS15240 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) GO012_RS15245 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) GO012_RS15255 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) GO012_RS15260 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GO012_RS15265 ENOG4105CHH sulfate transporter GO012_RS15275 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria GO012_RS15285 ENOG4105C3G gtp-binding protein GO012_RS15350 ENOG4105E6M Sulphatase-modifying factor protein GO012_RS15360 ENOG4105E6M Sulphatase-modifying factor protein GO012_RS15375 ENOG4105CS6 Rhs element vgr protein GO012_RS15380 ENOG4108ZG0 Ompa motb domain protein GO012_RS15400 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme GO012_RS15405 ENOG4105D3G Pseudouridine synthase GO012_RS15415 ENOG4105F04 LysR family Transcriptional regulator GO012_RS15425 ENOG4105CSH Transporter GO012_RS15445 ENOG4107YNJ LysR family Transcriptional regulator GO012_RS15450 ENOG4108IV0 ABC, transporter GO012_RS15455 ENOG4105C0Z ABC transporter GO012_RS15460 ENOG4105CF8 branched-chain amino acid ABC transporter, permease GO012_RS15465 ENOG4105C32 Amino acid ABC transporter (Permease) GO012_RS15475 ENOG4105C6N Formate acetyltransferase GO012_RS15490 ENOG4105C7B Threonine dehydratase GO012_RS15495 ENOG410811B TRANSCRIPTIONal GO012_RS15550 ENOG4105E0K tonB-dependent siderophore receptor GO012_RS15555 ENOG4106JQ5 Transglycosylase SLT domain GO012_RS15560 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GO012_RS15565 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) GO012_RS15575 ENOG4105MWK D-amino acid dehydrogenase, small subunit GO012_RS15580 ENOG4105ED1 spovr family GO012_RS15585 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) GO012_RS15590 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) GO012_RS15605 ENOG4108ZZ3 UPF0260 protein GO012_RS15610 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase GO012_RS15615 ENOG4105VNG YcgL domain-containing protein GO012_RS15620 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) GO012_RS15625 ENOG4107QMS site-determining protein GO012_RS15630 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) GO012_RS15635 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) GO012_RS15640 ENOG4105CEY Amp-dependent synthetase and ligase GO012_RS15645 ENOG4105Y4Z Outer Membrane Lipoprotein GO012_RS15650 ENOG41072GX Peptidase M22 Glycoprotease GO012_RS15655 ENOG4105DVT helicase GO012_RS15660 ENOG4105M4H endoribonuclease L-psp GO012_RS15665 ENOG4105X5C UPF0181 protein GO012_RS15675 ENOG4105P8F nudix hydrolase GO012_RS15680 ENOG4105EJQ L-serine dehydratase GO012_RS15685 ENOG4107XTP (EAL) domain protein GO012_RS15690 ENOG4105EE5 Membrane protein terC GO012_RS15695 ENOG4108EQA pts system GO012_RS15700 ENOG4105ETZ PTS System GO012_RS15705 ENOG4105F3R pts system mannose fructose sorbose family iid GO012_RS15710 ENOG4108NK4 UPF0266 membrane protein GO012_RS15715 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) GO012_RS15720 ENOG4105DHI Methyltransferase GO012_RS15725 ENOG4105CJN penicillin-binding protein GO012_RS15730 ENOG4105VEQ Cold shock protein GO012_RS15735 ENOG410610J Protein of unknown function (DUF2627) GO012_RS15740 ENOG4105Q3Y exported protein GO012_RS15750 ENOG4105TIK GO012_RS15755 ENOG4105J4Q Transcriptional regulator GO012_RS15760 ENOG4105C0R drug resistance transporter emrb qaca subfamily GO012_RS15765 ENOG4105D0M Protease HtpX homolog GO012_RS15770 ENOG4105CN1 protease GO012_RS15775 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) GO012_RS15780 ENOG4108ZGC gaf domain protein GO012_RS15785 ENOG4105H2K paraquat-inducible protein a GO012_RS15790 ENOG4105DY2 Paraquat-inducible protein b GO012_RS15795 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GO012_RS15800 ENOG4105WT8 Protein of unknown function (DUF1480) GO012_RS15805 ENOG4105UVW uncharacterized protein yebW GO012_RS15810 ENOG4108R1E Serine threonine protein phosphatase 1 GO012_RS15815 ENOG4108MJ5 VirK protein GO012_RS15825 ENOG4105NKT exported protein GO012_RS15835 ENOG4105FXM Copper resistance protein GO012_RS15840 ENOG4105MPK DNA polymerase III subunit theta GO012_RS15845 ENOG4105UMD exodeoxyribonuclease X GO012_RS15850 ENOG4105CUG Oligopeptidase b GO012_RS15855 ENOG4108Q2J Inner membrane protein YebE GO012_RS15860 ENOG4105X2V dna damage-inducible protein GO012_RS15870 ENOG4108UHU Aldolase GO012_RS15875 ENOG4105C01 Dihydroxy-acid dehydratase GO012_RS15880 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase GO012_RS15885 ENOG4106KNT transcriptional regulator GO012_RS15890 ENOG4105CA9 Pyruvate kinase GO012_RS15895 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase GO012_RS15900 ENOG4105DR5 peptidase GO012_RS15905 ENOG4105NXV High-affinity zinc uptake system protein GO012_RS15915 ENOG4105FAV ABC, transporter GO012_RS15920 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GO012_RS15930 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) GO012_RS15940 ENOG4108TIT dATP pyrophosphohydrolase GO012_RS15945 ENOG4105C9M aspartyl-trna synthetase GO012_RS15950 ENOG4105D3W isochorismatase GO012_RS15955 ENOG41081XQ Conserved Protein GO012_RS15960 ENOG4105WJG Glutathione GO012_RS15965 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) GO012_RS15970 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) GO012_RS15975 ENOG4106N3A copper homeostasis protein cutc GO012_RS15980 ENOG4106ZCM YecM protein GO012_RS15985 ENOG4105C75 arginyL-tRNA synthetase GO012_RS15990 ENOG4105F5H Glycosyl Hydrolase Family 88 GO012_RS15995 ENOG4105CT4 transporter GO012_RS16000 ENOG4108VA4 Universal stress protein GO012_RS16005 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase GO012_RS16015 ENOG4105CNN ABC, transporter GO012_RS16025 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator GO012_RS16030 ENOG4108UEC Ferritin-like protein GO012_RS16040 ENOG4105N4N Protein of unknown function (DUF2766) GO012_RS16045 ENOG4105C0R drug resistance transporter emrb qaca subfamily GO012_RS16060 ENOG41090A1 ferritin GO012_RS16065 ENOG4105VVZ metal-binding protein GO012_RS16070 ENOG4105E0U tyrosine-specific transport protein GO012_RS16075 ENOG4106RHG Yeca family GO012_RS16100 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase GO012_RS16110 ENOG4105WH1 Two component transcriptional regulator luxr family GO012_RS16115 ENOG4105XVG cytoplasmic protein GO012_RS16120 ENOG4105VJY transcriptional regulator GO012_RS16125 ENOG4105CDA abc transporter atp-binding protein GO012_RS16130 ENOG4105E5Q amino acid AbC transporter GO012_RS16135 ENOG4105K6H D-cysteine desulfhydrase GO012_RS16140 ENOG4105EAB amino acid AbC transporter GO012_RS16145 ENOG4105E5K Alpha-amylase GO012_RS16150 ENOG4105JCU Inherit from NOG: (Lipo)protein GO012_RS16165 ENOG4105YX3 cellular response to acidity GO012_RS16175 ENOG4105CKW Inner membrane protein yedI GO012_RS16180 ENOG4105FDR Membrane GO012_RS16185 ENOG41090BB DNA mismatch endonuclease (vsr) GO012_RS16190 ENOG4105DVF Cytosine-specific methyltransferase GO012_RS16195 ENOG4105EST Metal Dependent Phosphohydrolase GO012_RS16200 ENOG4105Y0K Inner membrane protein YedR GO012_RS16205 ENOG4105FCK Membrane GO012_RS16215 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) GO012_RS16225 ENOG4108UQ8 endoribonuclease L-psp GO012_RS16240 ENOG4108PXI ErfK YbiS YcfS YnhG GO012_RS16245 ENOG4107R11 Transcriptional regulator GO012_RS16260 ENOG4105EEQ Na H antiporter GO012_RS16265 ENOG4108WUH Transcriptional regulator, TetR family GO012_RS16270 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family GO012_RS16290 ENOG4105FYV Amp nucleosidase GO012_RS16315 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) GO012_RS16325 ENOG4108JJA ABC, transporter GO012_RS16330 ENOG4108MBX Secretion Protein GO012_RS16335 ENOG41090Q8 at two internal lysine residues, thereby converting it to the active toxin. The acyl donor is ACP GO012_RS16380 ENOG4105UQX Mate efflux family protein GO012_RS16400 ENOG4105DIK (ABC) transporter GO012_RS16405 ENOG4105CC5 ABC transporter GO012_RS16410 ENOG4105DSE periplasmic solute binding protein GO012_RS16435 ENOG4105D52 delta-aminolevulinic acid dehydratase GO012_RS16440 ENOG4105CD3 dihydroorotase GO012_RS16450 ENOG4105C22 threonyL-tRNA synthetase GO012_RS16455 ENOG4105DSE periplasmic solute binding protein GO012_RS16460 ENOG4105DIK (ABC) transporter GO012_RS16465 ENOG4105CC5 ABC transporter GO012_RS16470 ENOG4105CC5 ABC transporter GO012_RS16485 ENOG4108Z0R Transferase GO012_RS16490 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) GO012_RS16495 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters GO012_RS16500 ENOG4105CKI cobalamin synthesis protein GO012_RS16510 ENOG4105C8N cysteinyl-tRNA synthetase GO012_RS16515 ENOG4107T5J pyridine nucleotide-disulfide oxidoreductase GO012_RS16525 ENOG4105CKI cobalamin synthesis protein GO012_RS16535 ENOG4105MYN Zinc uptake regulation protein GO012_RS16540 ENOG4105EHG Permease protein GO012_RS16565 ENOG4105EYM Major Facilitator superfamily GO012_RS16570 ENOG4105BZ1 (ABC) transporter GO012_RS16585 ENOG4105C0W non-ribosomal peptide synthetase GO012_RS16605 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase GO012_RS16610 ENOG4107ZSV Receptor GO012_RS16690 ENOG4108PCE TRANSFER protein GO012_RS16740 ENOG4108VTW Thioesterase GO012_RS16765 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GO012_RS16795 ENOG4105C1G acyl-Coa dehydrogenase GO012_RS16800 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) GO012_RS16805 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GO012_RS16820 ENOG4105WH1 Two component transcriptional regulator luxr family GO012_RS16855 ENOG4105BZU Histidine kinase GO012_RS16870 ENOG4105ETT transcriptional Regulator, LysR family GO012_RS16875 ENOG4105YP6 Domain of unknown function (DUF1869) GO012_RS16880 ENOG4108YS1 cytoplasmic protein GO012_RS16885 ENOG4105BZU Histidine kinase GO012_RS16895 ENOG4105CSH Transporter GO012_RS16905 ENOG4105HEI LysR family (Transcriptional regulator GO012_RS16910 ENOG41090U3 tautomerase GO012_RS16920 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) GO012_RS16925 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) GO012_RS16930 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) GO012_RS16940 ENOG4105DR8 Membrane GO012_RS16950 ENOG4105EKQ RNA-directed DNA polymerase GO012_RS16955 ENOG4105DZ1 carboxypeptidase GO012_RS16960 ENOG4105CJB Exodeoxyribonuclease I GO012_RS16965 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GO012_RS16970 ENOG4105YVS arsR family transcriptional regulator GO012_RS16975 ENOG4105CUB amino acid GO012_RS16985 ENOG4105EQ1 Transcriptional regulator GO012_RS16990 ENOG4108535 NAD dependent epimerase/dehydratase family GO012_RS17010 ENOG4105CIH Imidazole acetol-phosphate transaminase GO012_RS17015 ENOG4105ECC imidazole-glycerol-phosphate dehydratase GO012_RS17020 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) GO012_RS17030 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) GO012_RS17035 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase GO012_RS17060 ENOG4105CPK Glycosyl transferase (Group 1 GO012_RS17115 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) GO012_RS17125 ENOG4106CD9 glycosyl transferase group 1 GO012_RS17130 ENOG4105FGF GDP-mannose mannosyl hydrolase GO012_RS17135 ENOG4105C30 Nad-dependent epimerase dehydratase GO012_RS17140 ENOG4105C0K Gdp-mannose 4,6-dehydratase GO012_RS17145 ENOG4108UW5 maltose o-acetyltransferase GO012_RS17150 ENOG4107XU6 Glycosyl transferase (Group 1 GO012_RS17175 ENOG4107ZF2 Phosphatase GO012_RS17180 ENOG4105DAY polysaccharide export protein GO012_RS17185 ENOG4108MRJ GO012_RS17190 ENOG4105MH5 phosphoesterase PA-phosphatase related protein GO012_RS17195 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GO012_RS17200 ENOG4105EE5 Membrane protein terC GO012_RS17205 ENOG4108GAE asmA family GO012_RS17220 ENOG4105D03 DNA-3-methyladenine glycosylase II GO012_RS17225 ENOG4105R8A Heat shock protein GO012_RS17230 ENOG4105BZU Histidine kinase GO012_RS17250 ENOG4105CK2 sodium dicarboxylate symporter GO012_RS17255 ENOG4105ENT Efflux transporter rnd family, mfp subunit GO012_RS17260 ENOG4105BZS acriflavin resistance protein GO012_RS17265 ENOG4105BZS acriflavin resistance protein GO012_RS17270 ENOG4105C0R drug resistance transporter emrb qaca subfamily GO012_RS17275 ENOG4105EB3 Histidine kinase GO012_RS17280 ENOG4105E3W Two component transcriptional regulator (Winged helix family GO012_RS17285 ENOG4105CFP Peptidase U32 GO012_RS17295 ENOG4108JQ7 (ABC) transporter GO012_RS17305 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GO012_RS17310 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GO012_RS17315 ENOG4105DEF Extracellular solute-binding protein, family 5 GO012_RS17320 ENOG4105CXK mandelate racemase muconate lactonizing GO012_RS17325 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 GO012_RS17330 ENOG4105IE8 Alpha-ketoglutarate permease GO012_RS17335 ENOG4105CMG Carbohydrate kinase GO012_RS17340 ENOG4105DEI Mannitol dehydrogenase GO012_RS17365 ENOG4105IE8 Alpha-ketoglutarate permease GO012_RS17370 ENOG4105EIE fructose-bisphosphate aldolase GO012_RS17375 ENOG4105DWF phosphomethylpyrimidine kinase GO012_RS17380 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase GO012_RS17410 ENOG4105EUZ Beta-lactamase domain protein GO012_RS17415 ENOG4105DUM transcriptional regulator, lysR family GO012_RS17420 ENOG4105CPN adenine deaminase GO012_RS17425 ENOG4105C7N Xanthine uracil vitamin C permease GO012_RS17430 ENOG4105EJC lysr family transcriptional regulator GO012_RS17435 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly GO012_RS17445 ENOG4105D1F ATP-binding protein GO012_RS17450 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GO012_RS17455 ENOG4108W15 Protein of unknown function (DUF1456) GO012_RS17460 ENOG4108NEV two component transcriptional regulator, LytTR family GO012_RS17465 ENOG4108HRK Histidine kinase GO012_RS17475 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component GO012_RS17480 ENOG4108IJ8 ABC transporter GO012_RS17485 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component GO012_RS17490 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system GO012_RS17495 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GO012_RS17500 ENOG4105CXG d-lactate dehydrogenase GO012_RS17510 ENOG41061WM D-Alanyl-D-Alanine GO012_RS17515 ENOG41069YE inner membrane protein yohC GO012_RS17520 ENOG4105KHU inner membrane protein YohD GO012_RS17530 ENOG4105CS2 ec 3.2.1.21 GO012_RS17545 ENOG4105TW1 Carbohydrate-selective porin OprB GO012_RS17550 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) GO012_RS17555 ENOG4105VAW lrga family GO012_RS17560 ENOG41067MG lrgb family GO012_RS17565 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) GO012_RS17570 ENOG4107GZ4 SanA protein GO012_RS17575 ENOG4107SDZ Galactoside transport system permease protein mglC GO012_RS17580 ENOG4105C2J ABC transporter GO012_RS17590 ENOG41060NJ transcriptional regulator GO012_RS17595 ENOG4105DHF Membrane GO012_RS17600 ENOG4105EUJ GTP cyclohydrolase i GO012_RS17610 ENOG4105D05 Receptor GO012_RS17615 ENOG4108IQI permease GO012_RS17620 ENOG4105DUM transcriptional regulator, lysR family GO012_RS17625 ENOG4105HMI Membrane GO012_RS17630 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) GO012_RS17635 ENOG4105DM4 PTS System GO012_RS17640 ENOG4105DE4 1-phosphofructokinase GO012_RS17645 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein GO012_RS17650 ENOG4105S8Q sugar efflux transporter GO012_RS17655 ENOG4105KRS Proteinase inhibitor GO012_RS17665 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) GO012_RS17670 ENOG4105DEI Mannitol dehydrogenase GO012_RS17675 ENOG4105CKI cobalamin synthesis protein GO012_RS17680 ENOG41076MN Phosphoesterase, PA-phosphatase related GO012_RS17685 ENOG4107TT5 NLP P60 protein GO012_RS17690 ENOG4105CXC rtn protein GO012_RS17695 ENOG4105E43 Extracellular solute-binding protein, family 5 GO012_RS17700 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component GO012_RS17705 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component GO012_RS17710 ENOG4108JQ5 ABC transporter GO012_RS17715 ENOG4105HG6 GO012_RS17720 ENOG4105C2C drug resistance transporter, Bcr CflA GO012_RS17725 ENOG4105I08 Pseudouridine synthase GO012_RS17730 ENOG4105CFI type iii restriction protein res subunit GO012_RS17735 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) GO012_RS17750 ENOG4107VIJ nudix hydrolase GO012_RS17755 ENOG4105N2W Transcriptional regulator GO012_RS17760 ENOG4106V8H Nucleoid-associated protein GO012_RS17765 ENOG4105PAN UPF0352 protein GO012_RS17770 ENOG4105E68 Sulfatase GO012_RS17780 ENOG4105F4G Membrane GO012_RS17795 ENOG4105CHH sulfate transporter GO012_RS17800 ENOG4105CJW magnesium transporter GO012_RS17805 ENOG4105IBP Cyclic peptide transporter GO012_RS17810 ENOG4105CF1 Alkylated DNA repair protein GO012_RS17815 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GO012_RS17830 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC GO012_RS17835 ENOG41068CG regulatoR GO012_RS17840 ENOG4105BZU Histidine kinase GO012_RS17845 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GO012_RS17850 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GO012_RS17855 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GO012_RS17860 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GO012_RS17865 ENOG4105XPH Ferredoxin GO012_RS17870 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase GO012_RS17875 ENOG4105CXY transporter GO012_RS17880 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A GO012_RS17885 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B GO012_RS17890 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GO012_RS17895 ENOG4105CNV Aldolase GO012_RS17900 ENOG4105CSP Major Facilitator Superfamily GO012_RS17905 ENOG4105CXK mandelate racemase muconate lactonizing GO012_RS17910 ENOG4107258 Transcriptional regulator GO012_RS17920 ENOG4108UII YfaZ family GO012_RS17925 ENOG4105DNE Transposase GO012_RS17935 ENOG4105CEY Amp-dependent synthetase and ligase GO012_RS17940 ENOG4105DNI Converts SHCHC to OSB (By similarity) GO012_RS17945 ENOG4108IPT Naphthoate synthase GO012_RS17950 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) GO012_RS17955 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) GO012_RS17960 ENOG4105E4F Isochorismate synthase GO012_RS17965 ENOG4107YB6 acetyltransferase, (GNAT) family GO012_RS17970 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) GO012_RS17975 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GO012_RS17980 ENOG4105C8S subunit m GO012_RS17985 ENOG4105D65 subunit l GO012_RS17995 ENOG4107UFS subunit j GO012_RS18010 ENOG4107R0R NADH dehydrogenase subunit g GO012_RS18015 ENOG4107QIZ NADH dehydrogenase GO012_RS18020 ENOG4105GKE subunit e GO012_RS18025 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GO012_RS18035 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GO012_RS18040 ENOG4107NQ8 LysR family Transcriptional regulator GO012_RS18045 ENOG4105CHM Aminotransferase GO012_RS18055 ENOG4107QWE )-transporter GO012_RS18060 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 GO012_RS18075 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GO012_RS18080 ENOG4105C6K Malic enzyme GO012_RS18085 ENOG4105PTV Nudix Hydrolase GO012_RS18090 ENOG4108RE9 Phosphodiesterase GO012_RS18095 ENOG4108SHQ Glutathione S-transferase GO012_RS18100 ENOG4105CYM Glutathione S-transferase GO012_RS18105 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase GO012_RS18110 ENOG4105ECP epimerase GO012_RS18115 ENOG4105KNA -acetyltransferase GO012_RS18120 ENOG4108JEH abc transporter atp-binding protein GO012_RS18125 ENOG4106YG3 ABC transporter GO012_RS18130 ENOG4105DSP amino acid AbC transporter GO012_RS18135 ENOG4105E89 ABC transporter GO012_RS18140 ENOG4105E89 ABC transporter GO012_RS18145 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase GO012_RS18150 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase GO012_RS18155 ENOG4105E96 Colicin v production protein GO012_RS18160 ENOG4108S3P Sporulation domain protein GO012_RS18165 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GO012_RS18170 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) GO012_RS18175 ENOG4105DQR SNARE associated Golgi GO012_RS18180 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GO012_RS18185 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GO012_RS18195 ENOG4106WZ1 flagella biosynthesis regulator GO012_RS18200 ENOG4105F9N Major Facilitator Superfamily GO012_RS18205 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GO012_RS18210 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) GO012_RS18215 ENOG4105MH2 YfcL protein GO012_RS18220 ENOG4108BPE -transporting atpase GO012_RS18225 ENOG4105EJ9 Membrane GO012_RS18230 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) GO012_RS18235 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GO012_RS18240 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) GO012_RS18245 ENOG4108DG9 Smr protein MutS2 GO012_RS18250 ENOG4108BY2 phosphohistidine phosphatase GO012_RS18255 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GO012_RS18260 ENOG4105CHU acetyl-coa acetyltransferase GO012_RS18265 ENOG4105KZW UPF0381 protein GO012_RS18270 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation GO012_RS18275 ENOG410903C (LipO)protein GO012_RS18280 ENOG4105S64 Formate nitrite transporter GO012_RS18300 ENOG4105DND Transcriptional regulator GO012_RS18305 ENOG4107Y2X deaminase GO012_RS18310 ENOG4105DJ2 Major Facilitator Superfamily GO012_RS18320 ENOG4105CHM Aminotransferase GO012_RS18325 ENOG4108HRK Histidine kinase GO012_RS18330 ENOG4105DY9 regulatoR GO012_RS18335 ENOG4105CHC glucokinase (EC 2.7.1.2) GO012_RS18345 ENOG4107RA9 decarboxylase GO012_RS18350 ENOG4105CPC Aldo Keto reductase GO012_RS18355 ENOG4109076 Conserved Protein GO012_RS18360 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) GO012_RS18365 ENOG4105D9N nucleoside GO012_RS18370 ENOG4108KMM Diguanylate cyclase GO012_RS18385 ENOG4105HZG regulatoR GO012_RS18390 ENOG4105GXM Putative transcription regulator (DUF1323) GO012_RS18395 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) GO012_RS18425 ENOG4108M0I Transcriptional regulator GO012_RS18430 ENOG4105DHU Bile acid GO012_RS18435 ENOG4105VRT cytoplasmic protein GO012_RS18440 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GO012_RS18445 ENOG4108C6U receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) GO012_RS18450 ENOG4105EXN Sulfate transport protein CysZ GO012_RS18455 ENOG4105C6T cysteine synthase GO012_RS18460 ENOG4105KZ7 phosphocarrier protein hpr GO012_RS18470 ENOG4105C5Y PTS System GO012_RS18485 ENOG4105CSW GntR family transcriptional regulator GO012_RS18490 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein GO012_RS18495 ENOG4105C6T cysteine synthase GO012_RS18500 ENOG4108IJ6 ABC transporter GO012_RS18505 ENOG4105ECW sulfate abc transporter GO012_RS18510 ENOG4108I5D sulfate abc transporter GO012_RS18515 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein GO012_RS18525 ENOG4105EZR dyp-type peroxidase family protein GO012_RS18530 ENOG4105E7K (LipO)protein GO012_RS18535 ENOG4105QZU Inner membrane protein YfeZ GO012_RS18545 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase GO012_RS18550 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) GO012_RS18555 ENOG4108K3Z AraC family transcriptional regulator GO012_RS18560 ENOG4108X49 Ethanolamine utilization protein EutK GO012_RS18565 ENOG4106D67 ethanolamine utilization protein GO012_RS18575 ENOG4105CPD ethanolamine ammonia-lyase GO012_RS18580 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase GO012_RS18585 ENOG4105ENY Ethanolamine utilization protein eutH GO012_RS18590 ENOG4105C0A alcohol dehydrogenase GO012_RS18595 ENOG4107RWI ethanolamine utilization protein eutJ GO012_RS18600 ENOG4108EKI Dehydrogenase GO012_RS18605 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml GO012_RS18610 ENOG4105KNY Microcompartments protein GO012_RS18615 ENOG4108IJ2 phosphate acetyltransferase GO012_RS18620 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase GO012_RS18625 ENOG4105NDK ethanolamine utilization protein GO012_RS18630 ENOG4106S4J ethanolamine utilization protein EutP GO012_RS18635 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place GO012_RS18640 ENOG4105C6K Malic enzyme GO012_RS18645 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GO012_RS18650 ENOG4105CV1 Transketolase (EC 2.2.1.1) GO012_RS18655 ENOG4108PVD exported protein GO012_RS18660 ENOG4107VIJ nudix hydrolase GO012_RS18665 ENOG4105BZ8 glutamate synthase GO012_RS18670 ENOG4105BZS acriflavin resistance protein GO012_RS18680 ENOG4105KUZ arsenate reductase GO012_RS18685 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GO012_RS18690 ENOG4105XYK UPF0370 protein GO012_RS18695 ENOG4106KED esterase YpfH GO012_RS18700 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) GO012_RS18705 ENOG4105CGZ zinc metallopeptidase GO012_RS18715 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) GO012_RS18720 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GO012_RS18725 ENOG4105RH4 Glycine cleavage system transcriptional repressor GO012_RS18730 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GO012_RS18735 ENOG4105C02 permease GO012_RS18740 ENOG4105ERG peptidase m48, ste24p GO012_RS18745 ENOG4105K89 arsenate reductase GO012_RS18760 ENOG4105C2W permease GO012_RS18765 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) GO012_RS18770 ENOG4105CS2 ec 3.2.1.21 GO012_RS18775 ENOG41066F8 ROK family GO012_RS18780 ENOG4105CXB phosphoribosylaminoimidazole synthetase GO012_RS18785 ENOG4108V3E phosphoribosylglycinamide formyltransferase GO012_RS18790 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) GO012_RS18795 ENOG4105C9X ppx gppa phosphatase GO012_RS18800 ENOG4105BZU Histidine kinase GO012_RS18805 ENOG41062G3 Protein of unknown function (DUF2633) GO012_RS18820 ENOG4105C4X radical SAM domain protein GO012_RS18830 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GO012_RS18835 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GO012_RS18840 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GO012_RS18845 ENOG4105VPD cellular component movement GO012_RS18855 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) GO012_RS18860 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) GO012_RS18865 ENOG4105N21 Membrane GO012_RS18875 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GO012_RS18880 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) GO012_RS18885 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs GO012_RS18895 ENOG4108JQB penicillin-binding protein 1C GO012_RS18900 ENOG4105DN3 alpha-2-macroglobulin domain protein GO012_RS18905 ENOG4105KHC sulfurtransferase GO012_RS18915 ENOG4105YYA enhanced serine sensitivity protein SseB GO012_RS18920 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) GO012_RS18925 ENOG4105WVQ Fe-S assembly protein IscX GO012_RS18930 ENOG4108ZIT Ferredoxin, 2FE-2S GO012_RS18935 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB GO012_RS18940 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) GO012_RS18945 ENOG4108Z4V iron-sulfur cluster assembly GO012_RS18950 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins GO012_RS18955 ENOG4105C3J Cysteine desulfurase GO012_RS18960 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family GO012_RS18965 ENOG4105CVS RNA methyltransferase TrmH family, group 1 GO012_RS18970 ENOG4105ECY inositol monophosphatase GO012_RS18980 ENOG4105D7X high-affinity nickel-transporter GO012_RS18985 ENOG41065CD Exported protein GO012_RS18990 ENOG4108MN2 Stationary phase inducible protein CsiE GO012_RS18995 ENOG4105D8G Major Facilitator superfamily GO012_RS19000 ENOG4108ZKT aldose 1-epimerase GO012_RS19005 ENOG4107QNK )-transporter GO012_RS19010 ENOG4107HQ7 repeat protein GO012_RS19020 ENOG4108SB3 DoxX Family GO012_RS19025 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GO012_RS19030 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GO012_RS19035 ENOG4108YZA Nitrogen regulatory protein pii GO012_RS19040 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GO012_RS19045 ENOG4108SKK alpha helix protein GO012_RS19050 ENOG4107WP9 Histidine kinase GO012_RS19055 ENOG4108ETH Formylglycinamide ribotide synthetase GO012_RS19060 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) GO012_RS19065 ENOG4108Z6B deaminase GO012_RS19070 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB GO012_RS19075 ENOG4106G6Q Transcriptional regulator GO012_RS19080 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding GO012_RS19085 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) GO012_RS19090 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) GO012_RS19095 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) GO012_RS19100 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GO012_RS19110 ENOG4105C3F Signal peptidase i GO012_RS19115 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) GO012_RS19120 ENOG4105WMJ Positive regulator of sigma E, RseC MucC GO012_RS19125 ENOG4105VQK sigma E regulatory protein, MucB RseB GO012_RS19145 ENOG4108IYU L-aspartate oxidase GO012_RS19150 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) GO012_RS19155 ENOG4105C1J atp-dependent rna helicase GO012_RS19165 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GO012_RS19170 ENOG4105EIB trna rrna methyltransferase GO012_RS19175 ENOG4105K63 Thioredoxin GO012_RS19180 ENOG4106IUH DTW domain containing protein GO012_RS19185 ENOG4105CD5 CoA-binding domain protein GO012_RS19190 ENOG4105JIM Phosphatidylserine synthase GO012_RS19195 ENOG4105T42 (LipO)protein GO012_RS19200 ENOG4105CSH Transporter GO012_RS19225 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GO012_RS19230 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GO012_RS19235 ENOG4105C34 Pseudouridine synthase GO012_RS19240 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane GO012_RS19245 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA GO012_RS19255 ENOG4105CQC Prephenate dehydratase GO012_RS19265 ENOG4105EHE chorismate mutase- prephenate dehydrogenase GO012_RS19270 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GO012_RS19275 ENOG4108WS1 GO012_RS19280 ENOG4108KHX Diguanylate cyclase GO012_RS19285 ENOG41090EK ompa motb domain protein GO012_RS19300 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) GO012_RS19305 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) GO012_RS19310 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) GO012_RS19315 ENOG4105K5M 30s ribosomal protein S16 GO012_RS19320 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY GO012_RS19325 ENOG4106KVJ cytochrome C assembly protein GO012_RS19330 ENOG4108JU6 CBS domain protein GO012_RS19335 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ GO012_RS19345 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GO012_RS19350 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) GO012_RS19360 ENOG4108Z1B Cyclase dehydrase GO012_RS19390 ENOG4105UEI Transcriptional Regulator AraC Family GO012_RS19395 ENOG4105C1P efflux transporter, rnd family, mfp subunit GO012_RS19420 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) GO012_RS19430 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) GO012_RS19435 ENOG4105DJB Major Facilitator Superfamily GO012_RS19445 ENOG4108M8W Monooxygenase GO012_RS19450 ENOG4108YYH Nadph-dependent fmn reductase GO012_RS19455 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GO012_RS19500 ENOG41061H0 Monooxygenase GO012_RS19510 ENOG4105EVZ LysR family transcriptional regulator GO012_RS19515 ENOG4105CYW agmatinase GO012_RS19530 ENOG4106TNF Periplasmic binding protein GO012_RS19540 ENOG4105MP9 class II Aldolase GO012_RS19545 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase GO012_RS19550 ENOG4105EWI Short-chain dehydrogenase reductase Sdr GO012_RS19565 ENOG4108WQH regulatoR GO012_RS19575 ENOG4106P2F Pfam:Pili_assembly_C GO012_RS19580 ENOG4105CW0 outer membrane usher protein GO012_RS19595 ENOG4105CW0 outer membrane usher protein GO012_RS19600 ENOG4108VCD Chaperone GO012_RS19605 ENOG4105X0I Fimbrial GO012_RS19610 ENOG4105C26 Dehydrogenase GO012_RS19615 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family GO012_RS19620 ENOG4105CC0 LysR family Transcriptional regulator GO012_RS19630 ENOG41080HT Transcriptional regulator, arsr family GO012_RS19635 ENOG4108V62 Rhodanese domain protein GO012_RS19650 ENOG4108X73 DNA- binding protein GO012_RS19655 ENOG4108RNS Exports L-alanine (By similarity) GO012_RS19660 ENOG4108WMJ Protein of unknown function (DUF2002) GO012_RS19665 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) GO012_RS19670 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GO012_RS19675 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GO012_RS19680 ENOG4105WAZ (Glutaredoxin-like protein) NrdH GO012_RS19685 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) GO012_RS19690 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GO012_RS19695 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GO012_RS19700 ENOG4108IJ7 Glycine betaine GO012_RS19705 ENOG4108HQS Glycine betaine GO012_RS19710 ENOG4105GIJ Glycine betaine GO012_RS19715 ENOG4108UMN azlc family GO012_RS19720 ENOG4105ZED uncharacterized protein ygaH GO012_RS19725 ENOG4105NTK Transcriptional repressor Mpra GO012_RS19730 ENOG4105CW7 secretion protein, HlyD family GO012_RS19735 ENOG4105C0R drug resistance transporter emrb qaca subfamily GO012_RS19740 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GO012_RS19755 ENOG4105D9M gamma-glutamylcysteine synthetase GO012_RS19760 ENOG4105W39 Membrane GO012_RS19765 ENOG4107VXZ Hydrolase GO012_RS19770 ENOG4105K3G Periplasmic Protein GO012_RS19800 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) GO012_RS19805 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GO012_RS19810 ENOG4105Y3E Modulates RecA activity (By similarity) GO012_RS19815 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) GO012_RS19820 ENOG4107TH8 cina domain protein GO012_RS19825 ENOG4105DSE periplasmic solute binding protein GO012_RS19830 ENOG4105CC5 ABC transporter GO012_RS19845 ENOG4105CVE Lytic murein transglycosylase GO012_RS19850 ENOG410787A Pts system, glucitol sorbitol-specific GO012_RS19855 ENOG4105DZY Pts system, glucitol sorbitol-specific GO012_RS19860 ENOG4105VI0 Pts system, glucitol sorbitol-specific GO012_RS19865 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase GO012_RS19870 ENOG4105J92 DNA-binding transcriptional activator GutM GO012_RS19875 ENOG410804X Transcriptional regulator GO012_RS19885 ENOG4108JUA Transcriptional regulator GO012_RS19890 ENOG4105CNW domain protein GO012_RS19895 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase GO012_RS19905 ENOG4105C8H hydrogenase maturation protein Hypf GO012_RS19910 ENOG4108RC0 Electron transport protein GO012_RS19915 ENOG4105DDV Transcriptional regulator (LacI family GO012_RS19920 ENOG4105C5Y PTS System GO012_RS19925 ENOG4105CS2 ec 3.2.1.21 GO012_RS19935 ENOG4108MG9 hydrogenase 3 maturation protease GO012_RS19940 ENOG4105I6X formate hydrogenlyase maturation GO012_RS19945 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit GO012_RS19950 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit GO012_RS19955 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GO012_RS19960 ENOG4107TDF Formate hydrogenlyase subunit 4 GO012_RS19965 ENOG4107R30 NADH dehydrogenase GO012_RS19970 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) GO012_RS19975 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA GO012_RS19980 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) GO012_RS19985 ENOG4107RSS Hydrogenase accessory protein HypB GO012_RS19990 ENOG41083WG hydrogenase assembly chaperone GO012_RS19995 ENOG4105CQS hydrogenase expression formation protein HypD GO012_RS20000 ENOG4105C45 hydrogenase expression formation protein (HypE) GO012_RS20010 ENOG4105CS2 ec 3.2.1.21 GO012_RS20020 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) GO012_RS20025 ENOG4105CK1 PTS System GO012_RS20030 ENOG4105VZJ PTS System GO012_RS20035 ENOG4105CK1 PTS System GO012_RS20040 ENOG4105VCP PTS System GO012_RS20045 ENOG4105DKQ ROK family GO012_RS20050 ENOG4105DDV Transcriptional regulator (LacI family GO012_RS20060 ENOG4105DIK (ABC) transporter GO012_RS20065 ENOG4105CC5 ABC transporter GO012_RS20070 ENOG4105CC5 ABC transporter GO012_RS20075 ENOG4105VXR cytoplasmic protein GO012_RS20085 ENOG4108N2Y auxin Efflux GO012_RS20105 ENOG4106QJH hemin transport protein GO012_RS20110 ENOG4107R4I Periplasmic binding protein GO012_RS20115 ENOG4105EHG Permease protein GO012_RS20120 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) GO012_RS20125 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) GO012_RS20130 ENOG4107635 Hok Gef family protein GO012_RS20135 ENOG4105KZM cytoplasmic protein GO012_RS20140 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) GO012_RS20145 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase GO012_RS20170 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GO012_RS20175 ENOG4108K5P (LipO)protein GO012_RS20180 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GO012_RS20190 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) GO012_RS20195 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) GO012_RS20200 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) GO012_RS20210 ENOG4105N0Z inner membrane protein ygbE GO012_RS20230 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GO012_RS20235 ENOG4108MXK alkaline phosphatase isozyme conversion GO012_RS20240 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) GO012_RS20245 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) GO012_RS20250 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GO012_RS20255 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase GO012_RS20260 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) GO012_RS20270 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) GO012_RS20275 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GO012_RS20280 ENOG4105DXN mazG family GO012_RS20285 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GO012_RS20290 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GO012_RS20295 ENOG4105BZU Histidine kinase GO012_RS20305 ENOG4105BZW Glycerate kinase GO012_RS20310 ENOG4105EQX glucarate dehydratase GO012_RS20315 ENOG4105EQX glucarate dehydratase GO012_RS20320 ENOG4105DJB Major Facilitator Superfamily GO012_RS20325 ENOG4105QDK Flavodoxin GO012_RS20330 ENOG4105DR9 pseudouridine synthase GO012_RS20335 ENOG4105WP7 tRNA pseudouridine synthase C GO012_RS20340 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) GO012_RS20345 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) GO012_RS20350 ENOG4105EWT decarboxylase family GO012_RS20355 ENOG4105C44 Serine transporter GO012_RS20360 ENOG4105EJQ L-serine dehydratase GO012_RS20365 ENOG4105GVF (ABC) transporter GO012_RS20375 ENOG41079KZ Major Facilitator Superfamily GO012_RS20380 ENOG4105D01 (LipO)protein GO012_RS20385 ENOG4108UMI ABC transporter, permease GO012_RS20390 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GO012_RS20405 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GO012_RS20410 ENOG4108JU7 Transcriptional regulator GO012_RS20420 ENOG4105C0A alcohol dehydrogenase GO012_RS20425 ENOG4107W7X Aldolase GO012_RS20430 ENOG4105EDR glucose galactose transporter GO012_RS20435 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) GO012_RS20440 ENOG4105CMG Carbohydrate kinase GO012_RS20445 ENOG4105NWF RbsD or FucU transport GO012_RS20450 ENOG4107EDW L-fucose operon activator GO012_RS20460 ENOG4105M08 Membrane GO012_RS20465 ENOG4105ETT transcriptional Regulator, LysR family GO012_RS20470 ENOG4105M5B (LipO)protein GO012_RS20475 ENOG4105C9B Cysteine desulfurase GO012_RS20480 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) GO012_RS20485 ENOG4105CUZ uba thif-type nad fad binding protein GO012_RS20490 ENOG4105CA3 membrane-bound lytic murein transglycosylase GO012_RS20510 ENOG4108YZT Adenosylcobinamide kinase GO012_RS20515 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) GO012_RS20525 ENOG4108V4M Cobalt abc transporter GO012_RS20530 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) GO012_RS20535 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) GO012_RS20540 ENOG4105DVK Precorrin-2 c20-methyltransferase GO012_RS20545 ENOG4107PPM cobalt chelatase GO012_RS20550 ENOG4105QUC reductase GO012_RS20555 ENOG4105E4R Precorrin-3B C17-methyltransferase GO012_RS20560 ENOG4108P62 biosynthesis protein (CbiG) GO012_RS20565 ENOG4105CIA precorrin-4 C(11)-methyltransferase GO012_RS20570 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase GO012_RS20575 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase GO012_RS20580 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) GO012_RS20585 ENOG41081F0 Precorrin-8x methylmutase GO012_RS20590 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) GO012_RS20595 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) GO012_RS20600 ENOG4107XVH Transcriptional regulator GO012_RS20605 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GO012_RS20610 ENOG4105KNY Microcompartments protein GO012_RS20615 ENOG4105EHR propanediol utilization protein pduB GO012_RS20620 ENOG4105DMB glycerol dehydratase GO012_RS20625 ENOG4105YCI dehydratase medium subunit GO012_RS20630 ENOG4108ZFT Dehydratase small subunit GO012_RS20635 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit GO012_RS20645 ENOG4105KNY Microcompartments protein GO012_RS20650 ENOG4105KNY Microcompartments protein GO012_RS20665 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml GO012_RS20675 ENOG4108EKI Dehydrogenase GO012_RS20680 ENOG4108EKI Dehydrogenase GO012_RS20685 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) GO012_RS20695 ENOG4105M3W utilization protein GO012_RS20700 ENOG4105KTW ethanolamine utilization protein GO012_RS20705 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GO012_RS20710 ENOG4105JZC GHMP kinase GO012_RS20715 ENOG4107QZB decarboxylase GO012_RS20720 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GO012_RS20725 ENOG4107QZM n-acetylglutamate synthase GO012_RS20735 ENOG4107QYX exodeoxyribonuclease v alpha GO012_RS20740 ENOG4107QKA exodeoxyribonuclease V beta GO012_RS20745 ENOG4107QXK peptidase GO012_RS20750 ENOG4105DSY exodeoxyribonuclease V, gamma GO012_RS20755 ENOG4105RVB Prepilin peptidase dependent protein c GO012_RS20760 ENOG4105SEN Protein of unknown function (DUF2509) GO012_RS20765 ENOG4105JCS prepilin peptidase dependent protein GO012_RS20770 ENOG4105IPU prepilin peptidase dependent protein A GO012_RS20775 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) GO012_RS20780 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) GO012_RS20785 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase GO012_RS20790 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GO012_RS20795 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) GO012_RS20800 ENOG4105EE5 Membrane protein terC GO012_RS20805 ENOG4105SUV lipoprotein YgdR GO012_RS20810 ENOG4105CPC Aldo Keto reductase GO012_RS20815 ENOG4107S74 Lysophospholipid transporter LplT GO012_RS20820 ENOG4105CEY Amp-dependent synthetase and ligase GO012_RS20825 ENOG41060NJ transcriptional regulator GO012_RS20835 ENOG4107YCY Transcriptional regulator GO012_RS20840 ENOG4105CS2 ec 3.2.1.21 GO012_RS20845 ENOG4105CK1 PTS System GO012_RS20850 ENOG4105DDV Transcriptional regulator (LacI family GO012_RS20855 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GO012_RS20860 ENOG4105RQF LysR family Transcriptional regulator GO012_RS20870 ENOG4105YKW GO012_RS20875 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component GO012_RS20880 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component GO012_RS20885 ENOG4108IJ9 (ABC) transporter GO012_RS20900 ENOG4108HKT sucrose-6-phosphate hydrolase GO012_RS20905 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) GO012_RS20910 ENOG4106NDP Transcriptional regulator GO012_RS20915 ENOG4107QNK )-transporter GO012_RS20920 ENOG4105CHR reductase GO012_RS20925 ENOG4105CAZ oligogalacturonide lyase GO012_RS20930 ENOG4108QGT oligogalacturonate-specific porin GO012_RS20935 ENOG4105CHU acetyl-coa acetyltransferase GO012_RS20940 ENOG4105C5Q Transcriptional regulator GO012_RS20950 ENOG4108MHD transport protein GO012_RS20955 ENOG4107S5I aldo keto reductase GO012_RS20995 ENOG4108T1W Fimbrial subunit type 3 GO012_RS21005 ENOG4108KTG Membrane protein, drug metabolite transporter GO012_RS21010 ENOG4108ZT1 Transcriptional regulator GO012_RS21015 ENOG4105D7X high-affinity nickel-transporter GO012_RS21020 ENOG4108W9T type 1 fimbriae regulatory protein GO012_RS21025 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off GO012_RS21030 ENOG4108RQP Major type 1 subunit fimbrin GO012_RS21035 ENOG4108S54 Fimbrial protein GO012_RS21040 ENOG4108NAE Fimbrial chaperone protein GO012_RS21045 ENOG4105CW0 outer membrane usher protein GO012_RS21050 ENOG4108SQA Fimbrial GO012_RS21055 ENOG4108T65 Fimbrial GO012_RS21060 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin GO012_RS21070 ENOG410830R acetyltransferase GO012_RS21075 ENOG4105VR1 Pfam:DUF1271 GO012_RS21085 ENOG4105J12 Multidrug resistance protein mdtN GO012_RS21090 ENOG4108MI0 Resistance protein GO012_RS21095 ENOG4105ETP RND efflux system, outer membrane lipoprotein GO012_RS21100 ENOG4105V2F Uncharacterized protein yoac GO012_RS21105 ENOG4105DUX Transporter GO012_RS21110 ENOG4105K89 arsenate reductase GO012_RS21115 ENOG4107R5R arsenical pump membrane protein GO012_RS21140 ENOG4105W7K Transcriptional regulator GO012_RS21155 ENOG4105CPC Aldo Keto reductase GO012_RS21170 ENOG4105C0R drug resistance transporter emrb qaca subfamily GO012_RS21180 ENOG4108K5P (LipO)protein GO012_RS21185 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) GO012_RS21190 ENOG4105CRK lysyL-tRNA synthetase GO012_RS21200 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) GO012_RS21205 ENOG4105T95 Thiol disulfide interChange protein GO012_RS21210 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GO012_RS21215 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) GO012_RS21220 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB GO012_RS21225 ENOG4105Y75 tpr repeat protein GO012_RS21235 ENOG4108UT2 hemolysin iii GO012_RS21240 ENOG4105N5Z UPF0267 protein GO012_RS21245 ENOG4108Q3X Transcriptional regulator GO012_RS21250 ENOG4105CS2 ec 3.2.1.21 GO012_RS21270 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GO012_RS21275 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GO012_RS21280 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor GO012_RS21285 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) GO012_RS21290 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GO012_RS21295 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family GO012_RS21300 ENOG4105D0A hydroxylase GO012_RS21305 ENOG4107RAQ aminopeptidase GO012_RS21310 ENOG4105E07 UPF0149 protein GO012_RS21315 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) GO012_RS21325 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase GO012_RS21330 ENOG4108JQ1 Dehydrogenase GO012_RS21335 ENOG4105E66 phosphoriboisomerase A GO012_RS21340 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) GO012_RS21345 ENOG4105MPN Membrane GO012_RS21350 ENOG4108ZUB Lysine exporter protein (Lyse ygga) GO012_RS21355 ENOG4105D64 Mechanosensitive ion channel GO012_RS21360 ENOG4105D2N Aldolase GO012_RS21370 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GO012_RS21375 ENOG4105CV1 Transketolase (EC 2.2.1.1) GO012_RS21380 ENOG4108K0D peptidase, M48 GO012_RS21390 ENOG41090KI Outer membrane porin GO012_RS21415 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP GO012_RS21420 ENOG4107QNK )-transporter GO012_RS21425 ENOG4105GPY SprT protein GO012_RS21430 ENOG4105RWS endonuclease I GO012_RS21435 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) GO012_RS21440 ENOG4105D7Z glutathione synthase GO012_RS21445 ENOG4108UJU UPF0301 protein GO012_RS21450 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) GO012_RS21455 ENOG41086KC Transcriptional regulator GO012_RS21460 ENOG4105CZX twitching motility protein GO012_RS21465 ENOG4105DFA alanine racemase domain protein GO012_RS21470 ENOG4108VIA integral membrane protein GO012_RS21475 ENOG4105VZ9 UPF0235 protein GO012_RS21480 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GO012_RS21485 ENOG4105CSA Coproporphyrinogen iii oxidase GO012_RS21495 ENOG4105C2J ABC transporter GO012_RS21500 ENOG4107RNG ABC transporter GO012_RS21505 ENOG4105K33 Periplasmic Protein GO012_RS21510 ENOG41090ED Protein with unknown function (DUF469) GO012_RS21515 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) GO012_RS21520 ENOG4105CEN a g-specific adenine glycosylase GO012_RS21525 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) GO012_RS21530 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division GO012_RS21535 ENOG4105EAA nucleoside GO012_RS21540 ENOG4105CXN decarboxylase GO012_RS21545 ENOG4108UQV Membrane GO012_RS21590 ENOG4105C28 cystathionine GO012_RS21615 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GO012_RS21620 ENOG4106032 Glutathionylspermidine synthase GO012_RS21630 ENOG4105CYM Glutathione S-transferase GO012_RS21635 ENOG410900S Protein of unknown function (DUF2623) GO012_RS21645 ENOG4108TEB UPF0114 protein GO012_RS21650 ENOG4105E4I Glycoside hydrolase family 28 GO012_RS21655 ENOG4105CT4 transporter GO012_RS21660 ENOG4108ZZF transport protein (ExbD) GO012_RS21665 ENOG4105CWK Biopolymer transport protein, ExbB GO012_RS21670 ENOG4105C28 cystathionine GO012_RS21675 ENOG4108K81 inner membrane protein YghB GO012_RS21680 ENOG4105CF7 AraC family transcriptional regulator GO012_RS21685 ENOG4108I6A alcohol dehydrogenase GO012_RS21690 ENOG4105CV8 reductase GO012_RS21700 ENOG4105CCT upf0313 protein GO012_RS21705 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) GO012_RS21710 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase GO012_RS21715 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GO012_RS21720 ENOG4105F4I Transcriptional regulator GO012_RS21725 ENOG4105H4F exported protein GO012_RS21730 ENOG4105XJC Two component transcriptional regulator (Winged helix family GO012_RS21735 ENOG4105DHQ Histidine kinase GO012_RS21745 ENOG4105VRH Antibiotic biosynthesis monooxygenase GO012_RS21750 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GO012_RS21755 ENOG4105IPS esterase GO012_RS21760 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) GO012_RS21765 ENOG4108SX3 cytoplasmic protein GO012_RS21770 ENOG41087AY ADP-Ribose pyrophosphatase GO012_RS21780 ENOG4105F1G UPF0441 protein GO012_RS21785 ENOG4106032 Glutathionylspermidine synthase GO012_RS21790 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b GO012_RS21800 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) GO012_RS21805 ENOG4105W0Z cytoplasmic protein GO012_RS21815 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) GO012_RS21820 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) GO012_RS21825 ENOG4105I7R Adenylate cyclase GO012_RS21830 ENOG4106MWK domain protein GO012_RS21835 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate GO012_RS21840 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GO012_RS21845 ENOG4107ZVW dihydroneopterin aldolase GO012_RS21850 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) GO012_RS21855 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) GO012_RS21875 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) GO012_RS21880 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) GO012_RS21895 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GO012_RS21900 ENOG4105VCC 30S ribosomal protein S21 GO012_RS21905 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) GO012_RS21910 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GO012_RS21915 ENOG4108VCA G U mismatch-specific DNA glycosylase GO012_RS21935 ENOG4108WQH regulatoR GO012_RS21940 ENOG4105BZU Histidine kinase GO012_RS21945 ENOG4108V08 YfdX protein GO012_RS21950 ENOG4108YK4 Acid-resistance membrane protein GO012_RS21955 ENOG4105XXV Acid-resistance protein GO012_RS21960 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GO012_RS21965 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit GO012_RS21970 ENOG4108ZFT Dehydratase small subunit GO012_RS21975 ENOG4105YCI dehydratase medium subunit GO012_RS21990 ENOG4105C0A alcohol dehydrogenase GO012_RS22020 ENOG4105CMT Dihydroxyacetone kinase GO012_RS22025 ENOG4108UTZ Dihydroxyacetone kinase GO012_RS22040 ENOG4105Q26 Siderophore-interacting protein GO012_RS22045 ENOG4105NTW Transcriptional regulator GO012_RS22050 ENOG4105C8Y Acetylornithine aminotransferase GO012_RS22055 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound GO012_RS22060 ENOG41061GT Aldolase GO012_RS22065 ENOG4105D4B ABC, transporter GO012_RS22070 ENOG4105F5R ABC transporter GO012_RS22075 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane GO012_RS22080 ENOG4105C2J ABC transporter GO012_RS22085 ENOG4105DKT Transcriptional regulator GO012_RS22090 ENOG4107RYS Autoinducer-2 (AI-2) kinase GO012_RS22095 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GO012_RS22115 ENOG4108VKG metal-dependent hydrolase GO012_RS22120 ENOG4105EE0 oxidoreductase GO012_RS22125 ENOG4105DU1 integral membrane protein, terc GO012_RS22130 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) GO012_RS22135 ENOG4105P66 Membrane GO012_RS22140 ENOG4105CTX dehydratase GO012_RS22150 ENOG4105DPW Major facilitator superfamily MFS_1 GO012_RS22155 ENOG4107YCY Transcriptional regulator GO012_RS22160 ENOG4106W5V Membrane GO012_RS22165 ENOG4105VD9 Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) GO012_RS22170 ENOG4105WAY exported protein GO012_RS22175 ENOG4105NE1 Conserved Protein GO012_RS22180 ENOG41090KG Inner membrane protein YqjE GO012_RS22185 ENOG4105YJD GO012_RS22190 ENOG4108VBZ doxx family GO012_RS22195 ENOG4105CHF Glutathione S-transferase GO012_RS22200 ENOG4105KAF membrAne GO012_RS22205 ENOG4105CWB LysR family transcriptional Regulator GO012_RS22210 ENOG4108CNN domain protein GO012_RS22230 ENOG4105BZW Glycerate kinase GO012_RS22235 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GO012_RS22240 ENOG4105CNV Aldolase GO012_RS22245 ENOG4105DJB Major Facilitator Superfamily GO012_RS22255 ENOG4105CTX dehydratase GO012_RS22260 ENOG4107UEK pfkb domain protein GO012_RS22265 ENOG4105MVE transcriptional regulator GO012_RS22270 ENOG4105D2N Aldolase GO012_RS22275 ENOG4105DE4 1-phosphofructokinase GO012_RS22280 ENOG4105DM4 PTS System GO012_RS22285 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein GO012_RS22290 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of GO012_RS22295 ENOG41082GB PTS system galactitol-specific transporter subunit IIA GO012_RS22300 ENOG41090UW PTS System GO012_RS22305 ENOG4105DT3 PTS system, galactitol-specific IIc component GO012_RS22310 ENOG4107WTH Galactitol-1-phosphate dehydrogenase GO012_RS22320 ENOG4107R3N Filamentation induced by cAMP protein fic GO012_RS22325 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) GO012_RS22330 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) GO012_RS22335 ENOG41082RQ UPF0102 protein GO012_RS22345 ENOG4105W4M Transport-associated protein GO012_RS22350 ENOG4107S21 permease GO012_RS22355 ENOG4105K4T epimerase GO012_RS22360 ENOG4107R7Y intracellular protease Pfpi family GO012_RS22365 ENOG4108ZPB UPF0306 protein GO012_RS22370 ENOG41082IR Excinuclease ABC C subunit domain protein GO012_RS22375 ENOG4108YYD acetyltransferase GO012_RS22380 ENOG4105XPQ lipid carrier protein GO012_RS22385 ENOG4105CFP Peptidase U32 GO012_RS22390 ENOG4106RZ4 Peptidase U32 GO012_RS22395 ENOG4105DEN Luciferase family GO012_RS22400 ENOG4105CIC tryptophan-specific transport protein GO012_RS22405 ENOG4105C1J atp-dependent rna helicase GO012_RS22420 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) GO012_RS22425 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) GO012_RS22430 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) GO012_RS22440 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) GO012_RS22445 ENOG4105CHV Transcription elongation factor NusA GO012_RS22460 ENOG4105CDH Citrulline--aspartate ligase GO012_RS22465 ENOG4108PNB DNA-binding transcriptional regulator GO012_RS22470 ENOG4108UII YfaZ family GO012_RS22495 ENOG4105EEI dihydropteroate synthase GO012_RS22500 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GO012_RS22505 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) GO012_RS22510 ENOG4105HBR Rna-binding protein GO012_RS22515 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GO012_RS22520 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase GO012_RS22525 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control GO012_RS22530 ENOG4105QYV Membrane GO012_RS22545 ENOG4105EAH synthase GO012_RS22550 ENOG4105HVQ Regulatory factor of maltose metabolism GO012_RS22555 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GO012_RS22560 ENOG4105VFK BolA family GO012_RS22565 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane GO012_RS22570 ENOG4105E3I toluene tolerance GO012_RS22575 ENOG4107PE3 Mammalian cell entry related domain protein GO012_RS22580 ENOG4105CY3 ABC transporter, permease GO012_RS22585 ENOG4105DHJ ABC, transporter GO012_RS22590 ENOG4105FEU K -dependent Na -Ca exchanger GO012_RS22595 ENOG4105C2X Arabinose 5-phosphate isomerase GO012_RS22600 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase GO012_RS22605 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) GO012_RS22610 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA GO012_RS22615 ENOG4108IUZ ABC transporter GO012_RS22620 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GO012_RS22625 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA GO012_RS22630 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN GO012_RS22640 ENOG41080Z8 PHOSPHOCARRIER protein GO012_RS22650 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain GO012_RS22655 ENOG4105BZU Histidine kinase GO012_RS22660 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) GO012_RS22665 ENOG4105CPQ Dehydrogenase GO012_RS22670 ENOG4108I5G Major Facilitator superfamily GO012_RS22675 ENOG4105N5T Radical SAM Protein GO012_RS22680 ENOG4105CBC glutamate synthase GO012_RS22685 ENOG4105BZ8 glutamate synthase GO012_RS22690 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) GO012_RS22695 ENOG4105KB2 stringent starvation protein b GO012_RS22700 ENOG4107MKT Stringent starvation protein a GO012_RS22710 ENOG4108UJD 30S ribosomal protein S9 GO012_RS22720 ENOG4105D6Z AFG1 family ATPase GO012_RS22725 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III GO012_RS22730 ENOG4105C0H protease GO012_RS22735 ENOG4105C0H protease GO012_RS22745 ENOG4105D9Q decarboxylase (Beta subunit) GO012_RS22750 ENOG4107QSA Oxaloacetate decarboxylase GO012_RS22760 ENOG4107GFK fumarate GO012_RS22765 ENOG4106DSS Tartrate dehydratase subunit alpha GO012_RS22770 ENOG4105C8P )-transporter GO012_RS22785 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GO012_RS22795 ENOG4105RID UPF0379 protein yhcN GO012_RS22800 ENOG4105RID UPF0379 protein yhcN GO012_RS22805 ENOG4105UNR (Barnase) inhibitor GO012_RS22810 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) GO012_RS22825 ENOG4105CR8 Transcriptional regulator GO012_RS22830 ENOG4105D1U peptidase U62 modulator of DNA gyrase GO012_RS22835 ENOG4105QD6 exported protein GO012_RS22840 ENOG4105C03 ribonuclease GO012_RS22850 ENOG4105VQ7 Rod shape-determining protein MreD GO012_RS22855 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) GO012_RS22860 ENOG4105DFF Rod shape-determining protein mreb GO012_RS22865 ENOG41062P1 Diguanylate cyclase phosphodiesterase GO012_RS22875 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) GO012_RS22880 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) GO012_RS22890 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein GO012_RS22895 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GO012_RS22900 ENOG4105RG0 Membrane GO012_RS22905 ENOG4108IA2 Sodium pantothenate symporter GO012_RS22910 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) GO012_RS22915 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GO012_RS22920 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) GO012_RS22925 ENOG4108XG4 DNA-binding transcriptional regulator GO012_RS22930 ENOG4105C1P efflux transporter, rnd family, mfp subunit GO012_RS22935 ENOG4105BZS acriflavin resistance protein GO012_RS22940 ENOG4105XCM membrane LIPOPROTEIN GO012_RS22970 ENOG4108Z0R Transferase GO012_RS22975 ENOG4105SG3 Protein of unknown function (DUF1488) GO012_RS22980 ENOG4105E2X shikimate dehydrogenase GO012_RS22985 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GO012_RS22990 ENOG4108WI1 Dna topoisomerase GO012_RS23000 ENOG4105C79 DNA protecting protein DprA GO012_RS23005 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GO012_RS23010 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GO012_RS23015 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GO012_RS23020 ENOG4105C1A potassium transporter peripheral membrane GO012_RS23030 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system GO012_RS23035 ENOG4105W1Y Transcriptional regulator GO012_RS23040 ENOG4105VTS DnaJ-like, subfamily C GO012_RS23050 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GO012_RS23060 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) GO012_RS23070 ENOG41067V7 50S ribosomal protein L36 GO012_RS23075 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GO012_RS23085 ENOG4105VPB 50S ribosomal protein L30 GO012_RS23090 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) GO012_RS23095 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) GO012_RS23100 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) GO012_RS23105 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) GO012_RS23120 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) GO012_RS23125 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) GO012_RS23130 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal GO012_RS23140 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) GO012_RS23145 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) GO012_RS23155 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) GO012_RS23190 ENOG4108UQY Iron-storage protein GO012_RS23195 ENOG4105W53 bacterioferritin-associated ferredoxin GO012_RS23200 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GO012_RS23205 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GO012_RS23210 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) GO012_RS23220 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) GO012_RS23225 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) GO012_RS23230 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) GO012_RS23235 ENOG4105WWK YheO domain protein GO012_RS23240 ENOG4108V1T peptidylprolyl cis-trans isomerase GO012_RS23250 ENOG4108YZY peptidylprolyl cis-trans isomerase GO012_RS23255 ENOG4105VKU nucleicacid-binding protein GO012_RS23260 ENOG4105CKD glutathione-regulated potassium-efflux system protein GO012_RS23265 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein GO012_RS23270 ENOG4105C5H ABC transporter GO012_RS23275 ENOG4105DNZ Alpha Beta Hydrolase GO012_RS23280 ENOG4105YP7 UPF0270 protein GO012_RS23285 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) GO012_RS23290 ENOG4108UKZ OsmC family GO012_RS23300 ENOG410613R integral membrane protein, YccS YhfK family GO012_RS23305 ENOG4105C8Y Acetylornithine aminotransferase GO012_RS23315 ENOG4105MZU cell filamentation protein GO012_RS23320 ENOG4106195 uncharacterized protein yhfG GO012_RS23325 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) GO012_RS23330 ENOG4106DTQ Protein TsgA homolog GO012_RS23335 ENOG4105DZC cytosine deaminase GO012_RS23340 ENOG4107QZF nitrite reductase NADPH large subunit GO012_RS23345 ENOG4105WZK nitrite reductase NADPH small subunit GO012_RS23350 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GO012_RS23355 ENOG4105C31 Tryptophanyl-tRNA synthetase GO012_RS23365 ENOG4105DJV ribulose-phosphate 3-epimerase GO012_RS23370 ENOG4105DFE Dna adenine methylase GO012_RS23375 ENOG4105EGB membrane protein DamX GO012_RS23380 ENOG4105D49 3-dehydroquinate synthase GO012_RS23385 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) GO012_RS23390 ENOG4105E4G Type IV pilus GO012_RS23415 ENOG4108JQC penicillin-binding protein 1A GO012_RS23420 ENOG4107RK2 ADP-ribose diphosphatase NudE GO012_RS23425 ENOG4105DQY intracellular growth attenuator GO012_RS23430 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 GO012_RS23435 ENOG4105VEJ Heat shock protein GO012_RS23450 ENOG4105E0F Histidine kinase GO012_RS23455 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GO012_RS23460 ENOG4108RRZ Transcription elongation factor GreB GO012_RS23465 ENOG4105BZM domain protein GO012_RS23470 ENOG4105XFK Ferrous iron transport protein A GO012_RS23475 ENOG4105CE1 Ferrous iron transport protein b GO012_RS23480 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) GO012_RS23490 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) GO012_RS23495 ENOG4105MJ2 Competence protein GO012_RS23505 ENOG4105C6Z Gluconate GO012_RS23510 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) GO012_RS23515 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) GO012_RS23520 ENOG41061ZR Transcriptional regulator GO012_RS23525 ENOG4105E98 transcriptional regulator DeoR family GO012_RS23530 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) GO012_RS23535 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) GO012_RS23540 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GO012_RS23545 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) GO012_RS23550 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) GO012_RS23555 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) GO012_RS23560 ENOG4108IUM Glycogen debranching enzyme GO012_RS23565 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) GO012_RS23570 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GO012_RS23580 ENOG4105C6Z Gluconate GO012_RS23585 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family GO012_RS23590 ENOG4105DIQ Transcriptional regulator GO012_RS23595 ENOG4105C2I pirin domain protein GO012_RS23600 ENOG4105D9R oxidoreductase GO012_RS23610 ENOG4105WCN acetyltransferase GO012_RS23615 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GO012_RS23620 ENOG4105WC8 Conserved Protein GO012_RS23625 ENOG4107T6V glycerophosphoryl diester phosphodiesterase GO012_RS23640 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component GO012_RS23645 ENOG4105BZ7 extracellular solute-binding protein family 1 GO012_RS23655 ENOG41060M8 Pfam:PhdYeFM GO012_RS23660 ENOG4108IV0 ABC, transporter GO012_RS23665 ENOG4105C0Z ABC transporter GO012_RS23670 ENOG4105CF8 branched-chain amino acid ABC transporter, permease GO012_RS23675 ENOG4105C32 Amino acid ABC transporter (Permease) GO012_RS23680 ENOG4105CP9 extracellular ligand-binding receptor GO012_RS23690 ENOG4105U59 -acetyltransferase GO012_RS23695 ENOG4105CP9 extracellular ligand-binding receptor GO012_RS23705 ENOG4108JPW Aminotransferase GO012_RS23720 ENOG4105CRP Part of the ABC transporter FtsEX involved in GO012_RS23725 ENOG4105CAK Cell division ATP-binding protein ftsE GO012_RS23730 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) GO012_RS23735 ENOG4106H78 methyltransferase GO012_RS23740 ENOG4105MG3 Membrane GO012_RS23750 ENOG4107FS9 Membrane GO012_RS23765 ENOG4105EX9 Membrane GO012_RS23770 ENOG4108W1V Lipoprotein GO012_RS23775 ENOG4105F9N Major Facilitator Superfamily GO012_RS23780 ENOG4105DSF transport protein GO012_RS23785 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) GO012_RS23790 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) GO012_RS23795 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) GO012_RS23800 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) GO012_RS23805 ENOG4105C3I Nad-dependent epimerase dehydratase GO012_RS23810 ENOG4105CKK Glycosyl transferase, family 2 GO012_RS23815 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GO012_RS23820 ENOG4105PY6 Phenolic acid decarboxylase GO012_RS23830 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein GO012_RS23835 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GO012_RS23840 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GO012_RS23850 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) GO012_RS23865 ENOG4105CJW magnesium transporter GO012_RS23870 ENOG4105CBX hi0933 family GO012_RS23875 ENOG4105CJ3 phosphate transporter GO012_RS23885 ENOG4108M6U Universal stress protein A GO012_RS23890 ENOG4105DUX Transporter GO012_RS23895 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) GO012_RS23900 ENOG4105DGW oligopeptidase A GO012_RS23905 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase GO012_RS23910 ENOG4105D6S protein involved in catabolism of external DNA GO012_RS23915 ENOG4105DC8 reductase GO012_RS23925 ENOG4105C0A alcohol dehydrogenase GO012_RS23940 ENOG4105CHR reductase GO012_RS23945 ENOG4105CBN LysR family transcriptional regulator GO012_RS23950 ENOG4107H3J ribonuclease GO012_RS23955 ENOG4105CSH Transporter GO012_RS23960 ENOG41066T0 asmA family GO012_RS23975 ENOG4105CS0 peptidase GO012_RS23980 ENOG4105CK2 sodium dicarboxylate symporter GO012_RS23985 ENOG4105BZU Histidine kinase GO012_RS23990 ENOG4105EJG cellulose synthase GO012_RS23995 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) GO012_RS24000 ENOG4107EEX Cellulose synthase regulator protein GO012_RS24005 ENOG4107QZ7 Cellulose synthase catalytic subunit GO012_RS24010 ENOG4105UTS cellulose synthase operon protein YhjQ GO012_RS24015 ENOG410661M cytoplasmic protein GO012_RS24020 ENOG4105U74 cellulose biosynthesis protein BcsE GO012_RS24025 ENOG410675P Celllulose biosynthesis operon protein BcsF YhjT GO012_RS24030 ENOG4105D1V cellulose synthase operon protein YhjU GO012_RS24050 ENOG4107EEX Cellulose synthase regulator protein GO012_RS24055 ENOG4107QZ7 Cellulose synthase catalytic subunit GO012_RS24060 ENOG4107U53 septum site-determining protein minD GO012_RS24070 ENOG4108JQ7 (ABC) transporter GO012_RS24075 ENOG4105C3U ABC transporter GO012_RS24080 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GO012_RS24085 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GO012_RS24090 ENOG4105DEF Extracellular solute-binding protein, family 5 GO012_RS24110 ENOG4105DIJ Phosphoethanolamine transferase GO012_RS24115 ENOG4105FCD Major Facilitator GO012_RS24120 ENOG4105EAX Putative lipase GO012_RS24125 ENOG4108R3E Dna-3-methyladenine glycosylase i GO012_RS24130 ENOG4105HNP -acetyltransferase GO012_RS24135 ENOG4107QY8 reductase GO012_RS24140 ENOG4108ZG0 Ompa motb domain protein GO012_RS24145 ENOG4108M60 Transcriptional regulator GO012_RS24155 ENOG4105D7K pfkb domain protein GO012_RS24165 ENOG4105C5I Dehydrogenase GO012_RS24170 ENOG4106JH6 (LipO)protein GO012_RS24175 ENOG4105D2S major facilitator superfamily GO012_RS24180 ENOG4105MVF Transcriptional regulator GO012_RS24185 ENOG4105VEQ Cold shock protein GO012_RS24195 ENOG41060TC Hok gef cell toxic protein GO012_RS24200 ENOG4105C38 Glycyl-tRNA synthetase beta subunit GO012_RS24205 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit GO012_RS24215 ENOG4105MEV Acyl-transferase GO012_RS24220 ENOG4108Z12 YiaAB two helix domain-containing protein GO012_RS24225 ENOG410688U Inner membrane protein yiaB GO012_RS24230 ENOG4105CMG Carbohydrate kinase GO012_RS24235 ENOG4105C93 Xylose Isomerase GO012_RS24240 ENOG4105DFW ABC transporter GO012_RS24245 ENOG4105C2J ABC transporter GO012_RS24250 ENOG4107RNG ABC transporter GO012_RS24255 ENOG4105T16 Transcriptional regulator (AraC family) GO012_RS24260 ENOG4108UR8 BAX protein GO012_RS24265 ENOG4107T9C Alpha amylase catalytic region GO012_RS24270 ENOG4105JKW Valine--pyruvate aminotransferase GO012_RS24275 ENOG4108RC0 Electron transport protein GO012_RS24280 ENOG4105J4Q Transcriptional regulator GO012_RS24285 ENOG4105EM7 Selenocysteine-specific translation elongation factor GO012_RS24290 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) GO012_RS24295 ENOG4108U78 Glutathione S-transferase GO012_RS24305 ENOG4105CTS PTS system mannitol-specific GO012_RS24310 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase GO012_RS24315 ENOG4105E61 Mannitol repressor protein GO012_RS24325 ENOG4108YYI Protein of unknown function (DUF2810) GO012_RS24330 ENOG4105DAA L-lactate GO012_RS24335 ENOG41073TP transcriptional regulator GO012_RS24340 ENOG4105DMF Dehydrogenase GO012_RS24345 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) GO012_RS24350 ENOG4105D7W serine acetyltransferase GO012_RS24355 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GO012_RS24365 ENOG4105VW4 glutaredoxin 3 GO012_RS24370 ENOG4107YZP Rhodanese domain protein GO012_RS24380 ENOG41063SB peptidase GO012_RS24385 ENOG4105PXI polysaccharide deacetylase GO012_RS24390 ENOG4106WTF Glycosyl transferase, family 2 GO012_RS24395 ENOG4105CPQ Dehydrogenase GO012_RS24400 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GO012_RS24405 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) GO012_RS24410 ENOG4105XA0 heptosyltransferase ii GO012_RS24415 ENOG4105D16 lipopolysaccharide heptosyltransferase i GO012_RS24440 ENOG4105DKP glycosyl transferase, family 9 GO012_RS24450 ENOG4105CPK Glycosyl transferase (Group 1 GO012_RS24455 ENOG4105K64 Glycosyl transferase, family 2 GO012_RS24460 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase GO012_RS24465 ENOG4106WTF Glycosyl transferase, family 2 GO012_RS24470 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) GO012_RS24475 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) GO012_RS24490 ENOG4105W5Q DNA repair protein (RadC GO012_RS24495 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase GO012_RS24500 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) GO012_RS24505 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) GO012_RS24525 ENOG4107QWP ABC-2 type transporter GO012_RS24530 ENOG4105CJ1 ABC, transporter GO012_RS24545 ENOG4105DSJ YicC domain protein GO012_RS24550 ENOG4108JZP Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate (By similarity) GO012_RS24555 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GO012_RS24565 ENOG4105EN6 Membrane GO012_RS24570 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) GO012_RS24575 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) GO012_RS24580 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) GO012_RS24585 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GO012_RS24590 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase GO012_RS24595 ENOG4105CB5 ATP-dependent DNA helicase recG GO012_RS24600 ENOG4105CBT Fructose-1,6-bisphosphatase GO012_RS24605 ENOG4105DP0 ferredoxin-NADP reductase GO012_RS24610 ENOG4108VTS Membrane GO012_RS24615 ENOG4105EBK exported protein GO012_RS24620 ENOG4105CP7 Triose-phosphate isomerase GO012_RS24635 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein GO012_RS24640 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) GO012_RS24645 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GO012_RS24650 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GO012_RS24655 ENOG4105D6U Sodium Glutamate Symporter GO012_RS24660 ENOG4105C2W permease GO012_RS24665 ENOG4105JV1 AsmA family GO012_RS24670 ENOG4105CI1 PTS System GO012_RS24675 ENOG4105F8D glycoside hydrolase family 4 GO012_RS24685 ENOG4105CJQ hydrolase, family 31 GO012_RS24690 ENOG4105CT4 transporter GO012_RS24700 ENOG4105DFP Integrase GO012_RS24715 ENOG4105NI3 Protein of unknown function (DUF3237) GO012_RS24735 ENOG4105DQ4 alcohol dehydrogenase GO012_RS24745 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein GO012_RS24760 ENOG4105D01 (LipO)protein GO012_RS24785 ENOG4105CR8 Transcriptional regulator GO012_RS24795 ENOG410630P Transcriptional regulator GO012_RS24805 ENOG4105C1P efflux transporter, rnd family, mfp subunit GO012_RS24810 ENOG4105BZS acriflavin resistance protein GO012_RS24815 ENOG4105ENJ RND efflux system, outer membrane lipoprotein GO012_RS24820 ENOG4105C2C drug resistance transporter, Bcr CflA GO012_RS24825 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GO012_RS24830 ENOG4108EKE The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6-anhydro ring (By similarity) GO012_RS24835 ENOG4108UZ3 Transporter GO012_RS24840 ENOG4105T8A Uncharacterized protein YicS GO012_RS24855 ENOG4105JSC dimethylmenaquinone methyltransferase GO012_RS24865 ENOG4107F9Y LysR family transcriptional regulator GO012_RS24875 ENOG4105D2S major facilitator superfamily GO012_RS24880 ENOG4105ETE Transcriptional regulator (LacI family GO012_RS24890 ENOG4105CK1 PTS System GO012_RS24895 ENOG4105VCP PTS System GO012_RS24900 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) GO012_RS24910 ENOG4108MP3 ABC transporter, permease GO012_RS24925 ENOG4106S9K Transcriptional regulator GO012_RS24930 ENOG4107STF Involved in phosphonate degradation (By similarity) GO012_RS24935 ENOG4108KAZ Involved in phosphonate degradation (By similarity) GO012_RS24955 ENOG4108SAJ Protein of unknown function (DUF1198) GO012_RS24960 ENOG4105CXY transporter GO012_RS24965 ENOG4105CXY transporter GO012_RS24970 ENOG4105BZU Histidine kinase GO012_RS24975 ENOG4108KX4 response regulator GO012_RS24980 ENOG4105M71 acetolactate synthase 1 regulatory subunit GO012_RS24985 ENOG4105C7K acetolactate synthase GO012_RS25010 ENOG4105E5M Multidrug resistance protein D GO012_RS25015 ENOG4105W8I Transcriptional regulator GO012_RS25035 ENOG4105JP4 Inner membrane protein yidG GO012_RS25040 ENOG4105VG5 Membrane GO012_RS25045 ENOG4105F8D glycoside hydrolase family 4 GO012_RS25050 ENOG4105CI1 PTS System GO012_RS25055 ENOG4105FDP GntR family transcriptional regulator GO012_RS25060 ENOG4105D0C transport protein GO012_RS25065 ENOG4105F5P DNA-damage-inducible protein d GO012_RS25080 ENOG4105R2A (LipO)protein GO012_RS25085 ENOG4105D99 atp gtp-binding protein GO012_RS25090 ENOG4105DJB Major Facilitator Superfamily GO012_RS25095 ENOG4105CXK mandelate racemase muconate lactonizing GO012_RS25100 ENOG4108RTU Aldolase GO012_RS25105 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 GO012_RS25110 ENOG4105EMF GntR family transcriptional regulator GO012_RS25125 ENOG410667J hydrolase GO012_RS25130 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GO012_RS25135 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GO012_RS25140 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GO012_RS25160 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) GO012_RS25165 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GO012_RS25170 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) GO012_RS25180 ENOG4105C2C drug resistance transporter, Bcr CflA GO012_RS25190 ENOG4105E8Q phosphopantetheinyl transferase GO012_RS25195 ENOG4108YYH Nadph-dependent fmn reductase GO012_RS25200 ENOG4105C7N Xanthine uracil vitamin C permease GO012_RS25205 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 GO012_RS25210 ENOG4107VKM 6-phosphogluconolactonase GO012_RS25215 ENOG4105DYC esterase GO012_RS25220 ENOG4108P68 Outer membrane porin GO012_RS25230 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GO012_RS25235 ENOG4105E2Z phosphate ABC transporter (Permease GO012_RS25240 ENOG4105C8U phosphate abc transporter GO012_RS25245 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) GO012_RS25255 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GO012_RS25260 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) GO012_RS25265 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) GO012_RS25270 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) GO012_RS25275 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) GO012_RS25280 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GO012_RS25290 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GO012_RS25300 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation GO012_RS25305 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) GO012_RS25310 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) GO012_RS25315 ENOG4108WF3 methyltransferase GO012_RS25330 ENOG4105EHG Permease protein GO012_RS25340 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) GO012_RS25375 ENOG4108WF3 methyltransferase GO012_RS25390 ENOG4107TKS colanic acid capsular biosynthesis activation protein A GO012_RS25395 ENOG4105DWP Membrane GO012_RS25405 ENOG4107RNH Outer membrane receptor FepA GO012_RS25410 ENOG4105E93 esterase GO012_RS25430 ENOG4105GTN ParB Domain Protein Nuclease GO012_RS25435 ENOG4105BZV Phosphoadenosine phosphosulfate reductase GO012_RS25450 ENOG4108SF5 RNA Polymerase GO012_RS25460 ENOG4105GAV receptor GO012_RS25465 ENOG4108HUF Transporter GO012_RS25510 ENOG4105CV8 reductase GO012_RS25535 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GO012_RS25555 ENOG4108JQ6 ABC transporter GO012_RS25575 ENOG4105MYN Zinc uptake regulation protein GO012_RS25580 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase GO012_RS25585 ENOG4105CKI cobalamin synthesis protein GO012_RS25595 ENOG4107T5J pyridine nucleotide-disulfide oxidoreductase GO012_RS25610 ENOG4105CKI cobalamin synthesis protein GO012_RS25615 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters GO012_RS25625 ENOG4108Z0R Transferase GO012_RS25650 ENOG4105CD3 dihydroorotase GO012_RS25655 ENOG4105D52 delta-aminolevulinic acid dehydratase GO012_RS25735 ENOG4105RVE Uncharacterized protein conserved in bacteria (DUF2136) GO012_RS25740 ENOG4108Z3N Transcriptional regulator GO012_RS25810 ENOG4105VUF Transcriptional regulator GO012_RS25815 ENOG4105GR3 Histidine kinase GO012_RS25820 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GO012_RS25825 ENOG4108PG2 copper resistance GO012_RS25830 ENOG4105JDN Copper resistance protein GO012_RS25835 ENOG4105VR0 copper resistance GO012_RS25840 ENOG4105E3B Multicopper oxidase GO012_RS25850 ENOG4105DR5 peptidase GO012_RS25880 ENOG410624V efflux system protein GO012_RS25915 ENOG4105BZU Histidine kinase GO012_RS26005 ENOG4106JVB Replication Protein GO012_RS26010 ENOG4105EZN Cobyrinic acid ac-diamide synthase GO012_RS26015 ENOG4106JGA Chromosome (Plasmid) partitioning protein, ParB GO012_RS26035 ENOG4108YXQ IS66 Orf2 family protein GO012_RS26040 ENOG4105E5H Transposase GO012_RS26095 ENOG4105KF5 hemolysin expression-modulating protein GO012_RS26130 ENOG4107SQD Transcriptional regulator, GntR family GO012_RS26170 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GO012_RS26190 ENOG4108VBH Uncharacterized protein conserved in bacteria (DUF2251) GO012_RS26210 ENOG4108M24 von Willebrand factor, type A GO012_RS26215 ENOG4108M24 von Willebrand factor, type A GO012_RS26225 ENOG4108M24 von Willebrand factor, type A GO012_RS26245 ENOG4105DAX Pfam:DUF2983 GO012_RS26315 ENOG4107U2T alpha beta GO012_RS26345 ENOG4105DWP Membrane GO012_RS26350 ENOG4108XM1 transcriptional regulator AsnC family GO012_RS26400 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A GO012_RS26420 ENOG4108ZGC gaf domain protein GO012_RS26460 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) GO012_RS26465 ENOG4105DUU IucA IucC family protein GO012_RS26520 ENOG4105CKI cobalamin synthesis protein