locus-tag	class	description
I5M56_RS00005	COG0477	Major facilitator Superfamily
I5M56_RS00010	COG5544	Lipoprotein
I5M56_RS00015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5M56_RS00025	COG3148	PFAM DTW domain containing protein
I5M56_RS00030	COG3118	belongs to the thioredoxin family
I5M56_RS00035	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I5M56_RS00050	COG0513	Belongs to the DEAD box helicase family
I5M56_RS00060	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I5M56_RS00070	COG1595	DNA-templated transcription, initiation
I5M56_RS00075	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I5M56_RS00080	COG3026	antisigma factor binding
I5M56_RS00085	COG3086	response to oxidative stress
I5M56_RS00095	COG0681	Belongs to the peptidase S26 family
I5M56_RS00115	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I5M56_RS00125	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I5M56_RS00130	COG1737	Transcriptional regulator
I5M56_RS00135	COG0560	Phosphoserine phosphatase
I5M56_RS00150	COG0047	phosphoribosylformylglycinamidine synthase activity
I5M56_RS00150	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I5M56_RS00155	COG2205	protein histidine kinase activity
I5M56_RS00160	COG3170	Tfp pilus assembly protein FimV
I5M56_RS00165	COG2204	response regulator
I5M56_RS00170	COG0347	Belongs to the P(II) protein family
I5M56_RS00175	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5M56_RS00175	COG1017	nitric oxide dioxygenase activity
I5M56_RS00185	COG2259	Doxx family
I5M56_RS00190	COG2814	Major facilitator Superfamily
I5M56_RS00195	COG3711	transcriptional antiterminator
I5M56_RS00200	COG3683	transport system, periplasmic component
I5M56_RS00205	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I5M56_RS00235	COG0822	iron-sulfur transferase activity
I5M56_RS00255	COG0633	Ferredoxin
I5M56_RS00260	COG2975	iron-sulfur cluster assembly
I5M56_RS00285	COG2897	thiosulfate sulfurtransferase activity
I5M56_RS00290	COG2373	Large extracellular alpha-helical protein
I5M56_RS00295	COG4953	penicillin-binding protein 1C
I5M56_RS00325	COG2976	Protein conserved in bacteria
I5M56_RS00345	COG1645	bacterial-type flagellum-dependent swarming motility
I5M56_RS00355	COG0516	GMP reductase activity
I5M56_RS00355	COG0517	IMP dehydrogenase activity
I5M56_RS00380	COG2200	EAL domain
I5M56_RS00395	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I5M56_RS00410	COG2723	6-phospho-beta-galactosidase activity
I5M56_RS00420	COG2233	PERMEase
I5M56_RS00435	COG1393	Belongs to the ArsC family
I5M56_RS00440	COG4783	chaperone-mediated protein folding
I5M56_RS00450	COG0628	permease
I5M56_RS00455	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I5M56_RS00460	COG2716	regulation of RNA biosynthetic process
I5M56_RS00470	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I5M56_RS00480	COG2321	neutral zinc metallopeptidase
I5M56_RS00485	COG1444	tRNA N-acetyltransferase activity
I5M56_RS00490	COG0400	carboxylic ester hydrolase activity
I5M56_RS00505	COG1393	Belongs to the ArsC family
I5M56_RS00515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5M56_RS00520	COG0493	'glutamate synthase
I5M56_RS00520	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I5M56_RS00530	COG5342	invasion associated locus B
I5M56_RS00535	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I5M56_RS00540	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I5M56_RS00555	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5M56_RS00575	COG2837	iron assimilation
I5M56_RS00580	COG2852	Protein conserved in bacteria
I5M56_RS00585	COG4150	thiosulfate binding
I5M56_RS00590	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I5M56_RS00595	COG4208	sulfate ABC transporter
I5M56_RS00600	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I5M56_RS00610	COG4319	ketosteroid isomerase
I5M56_RS00645	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I5M56_RS00665	COG3530	Putative quorum-sensing-regulated virulence factor
I5M56_RS00670	COG0385	Bile acid
I5M56_RS00675	COG0583	DNA-binding transcription factor activity
I5M56_RS00710	COG3415	Transposase
I5M56_RS00715	COG3415	Transposase
I5M56_RS00730	COG2200	EAL domain
I5M56_RS00730	COG2199	diguanylate cyclase activity
I5M56_RS00735	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I5M56_RS00750	COG0667	Aldo Keto reductase
I5M56_RS00755	COG3961	Belongs to the TPP enzyme family
I5M56_RS00770	COG3279	Response regulator of the LytR AlgR family
I5M56_RS00775	COG3275	phosphorelay sensor kinase activity
I5M56_RS00785	COG0436	Aminotransferase
I5M56_RS00795	COG2807	transmembrane transport
I5M56_RS00800	COG0590	tRNA wobble adenosine to inosine editing
I5M56_RS00805	COG0583	DNA-binding transcription factor activity
I5M56_RS00820	COG3706	GGDEF domain
I5M56_RS00860	COG0582	viral genome integration into host DNA
I5M56_RS00870	COG2116	formate transmembrane transporter activity
I5M56_RS00875	COG2853	Lipoprotein
I5M56_RS00885	COG3691	Protein conserved in bacteria
I5M56_RS00900	COG2062	phosphohistidine phosphatase, SixA
I5M56_RS00925	COG0730	response to heat
I5M56_RS00930	COG3101	peptidyl-lysine hydroxylation
I5M56_RS00945	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I5M56_RS00965	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I5M56_RS00975	COG0586	Pfam SNARE associated Golgi protein
I5M56_RS00985	COG0285	dihydrofolate synthase activity
I5M56_RS00990	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I5M56_RS00995	COG1286	toxin biosynthetic process
I5M56_RS01000	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I5M56_RS01005	COG0163	prenyltransferase activity
I5M56_RS01030	COG4160	amino acid transport
I5M56_RS01035	COG4598	ABC transporter
I5M56_RS01050	COG1090	epimerase
I5M56_RS01055	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I5M56_RS01060	COG0625	glutathione transferase activity
I5M56_RS01065	COG0625	glutathione transferase activity
I5M56_RS01070	COG0622	Phosphoesterase
I5M56_RS01075	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I5M56_RS01100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5M56_RS01105	COG0490	domain, Protein
I5M56_RS01105	COG0471	metal ion transport
I5M56_RS01115	COG0436	Aminotransferase
I5M56_RS01120	COG0583	DNA-binding transcription factor activity
I5M56_RS01165	COG0839	Belongs to the complex I subunit 6 family
I5M56_RS01175	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I5M56_RS01180	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I5M56_RS01195	COG2153	protein acetylation
I5M56_RS01200	COG1169	isochorismate synthase
I5M56_RS01250	COG0642	Histidine kinase
I5M56_RS01270	COG1414	Transcriptional regulator
I5M56_RS01280	COG2271	Major facilitator Superfamily
I5M56_RS01290	COG0247	lactate metabolic process
I5M56_RS01300	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I5M56_RS01305	COG2271	Major facilitator Superfamily
I5M56_RS01310	COG0584	glycerophosphoryl diester phosphodiesterase
I5M56_RS01315	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5M56_RS01340	COG0784	Response regulator, receiver
I5M56_RS01340	COG2205	protein histidine kinase activity
I5M56_RS01350	COG0642	Histidine kinase
I5M56_RS01350	COG2198	Histidine kinase
I5M56_RS01365	COG2169	Transcriptional regulator
I5M56_RS01365	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I5M56_RS01370	COG3145	DNA-N1-methyladenine dioxygenase activity
I5M56_RS01375	COG4615	Cyclic peptide transporter
I5M56_RS01380	COG2239	Acts as a magnesium transporter
I5M56_RS01385	COG0659	secondary active sulfate transmembrane transporter activity
I5M56_RS01400	COG0628	permease
I5M56_RS01425	COG1349	DNA-binding transcription factor activity
I5M56_RS01430	COG0494	nUDIX hydrolase
I5M56_RS01450	COG1061	Type III restriction enzyme res subunit
I5M56_RS01455	COG1187	pseudouridine synthase activity
I5M56_RS01460	COG2814	Major facilitator Superfamily
I5M56_RS01470	COG4172	Belongs to the ABC transporter superfamily
I5M56_RS01475	COG4239	(ABC) transporter, permease
I5M56_RS01480	COG4174	ABC transporter (Permease)
I5M56_RS01485	COG4166	transmembrane transport
I5M56_RS01490	COG2200	EAL domain
I5M56_RS01495	COG0791	NLP P60 protein
I5M56_RS01500	COG0671	phosphoesterase, PA-phosphatase related
I5M56_RS01505	COG0523	cobalamin synthesis protein
I5M56_RS01510	COG0246	Mannitol dehydrogenase
I5M56_RS01515	COG1312	Catalyzes the dehydration of D-mannonate
I5M56_RS01540	COG1566	PFAM secretion protein HlyD family protein
I5M56_RS01545	COG2814	Major facilitator Superfamily
I5M56_RS01550	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M56_RS01550	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M56_RS01555	COG1105	Belongs to the carbohydrate kinase PfkB family
I5M56_RS01560	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5M56_RS01560	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5M56_RS01560	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I5M56_RS01570	COG2855	membrane
I5M56_RS01575	COG0583	DNA-binding transcription factor activity
I5M56_RS01580	COG0833	amino acid
I5M56_RS01585	COG4771	TonB-dependent receptor
I5M56_RS01600	COG2311	Membrane
I5M56_RS01615	COG1129	ABC transporter
I5M56_RS01625	COG2949	membrane
I5M56_RS01635	COG1346	cytolysis
I5M56_RS01645	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I5M56_RS01650	COG3659	wide pore channel activity
I5M56_RS01665	COG2723	6-phospho-beta-galactosidase activity
I5M56_RS01670	COG2226	methyltransferase
I5M56_RS01675	COG1538	Outer membrane efflux protein
I5M56_RS01680	COG0586	Pfam SNARE associated Golgi protein
I5M56_RS01690	COG1686	Belongs to the peptidase S11 family
I5M56_RS01700	COG0277	FAD linked oxidase domain protein
I5M56_RS01705	COG1472	Belongs to the glycosyl hydrolase 3 family
I5M56_RS01710	COG1732	Glycine betaine
I5M56_RS01715	COG1174	glycine betaine transport
I5M56_RS01720	COG1125	glycine betaine transport
I5M56_RS01725	COG1174	glycine betaine transport
I5M56_RS01735	COG3275	phosphorelay sensor kinase activity
I5M56_RS01745	COG4807	Protein conserved in bacteria
I5M56_RS01765	COG5455	response to cobalt ion
I5M56_RS01770	COG0583	DNA-binding transcription factor activity
I5M56_RS01775	COG2252	PERMEase
I5M56_RS01785	COG0583	DNA-binding transcription factor activity
I5M56_RS01795	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I5M56_RS01805	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I5M56_RS01815	COG0351	phosphomethylpyrimidine kinase
I5M56_RS01820	COG1830	Aldolase
I5M56_RS01855	COG1070	Carbohydrate kinase
I5M56_RS01865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5M56_RS01870	COG4948	Mandelate Racemase Muconate Lactonizing
I5M56_RS01875	COG0747	negative chemotaxis
I5M56_RS01880	COG0601	transmembrane transport
I5M56_RS01885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5M56_RS01890	COG0444	Belongs to the ABC transporter superfamily
I5M56_RS01895	COG4608	Belongs to the ABC transporter superfamily
I5M56_RS01905	COG0826	peptidase U32
I5M56_RS01910	COG0745	RESPONSE REGULATOR receiver
I5M56_RS01915	COG2205	protein histidine kinase activity
I5M56_RS01940	COG1301	dicarboxylic acid transport
I5M56_RS01960	COG2205	protein histidine kinase activity
I5M56_RS01965	COG0443	Heat shock 70 kDa protein
I5M56_RS01970	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I5M56_RS01985	COG2982	Protein involved in outer membrane biogenesis
I5M56_RS01990	COG1253	flavin adenine dinucleotide binding
I5M56_RS02035	COG0463	Glycosyl transferase, family 2
I5M56_RS02065	COG2244	polysaccharide biosynthetic process
I5M56_RS02100	COG1088	dTDP-glucose 4,6-dehydratase activity
I5M56_RS02155	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I5M56_RS02185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I5M56_RS02190	COG0583	DNA-binding transcription factor activity
I5M56_RS02200	COG0531	amino acid
I5M56_RS02205	COG0640	Transcriptional regulator
I5M56_RS02210	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I5M56_RS02215	COG2925	Exonuclease
I5M56_RS02230	COG1289	transmembrane transporter activity
I5M56_RS02250	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I5M56_RS02260	COG1942	4-Oxalocrotonate Tautomerase
I5M56_RS02265	COG0583	DNA-binding transcription factor activity
I5M56_RS02270	COG0095	Lipoate-protein ligase
I5M56_RS02275	COG0477	Major facilitator Superfamily
I5M56_RS02285	COG5001	Diguanylate cyclase
I5M56_RS02285	COG3300	MHYT domain
I5M56_RS02290	COG3615	Tellurite resistance protein tehB
I5M56_RS02315	COG3706	GGDEF domain
I5M56_RS02330	COG0534	Mate efflux family protein
I5M56_RS02340	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I5M56_RS02360	COG0604	alcohol dehydrogenase
I5M56_RS02365	COG1309	transcriptional regulator
I5M56_RS02370	COG0025	NhaP-type Na H and K H
I5M56_RS02490	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I5M56_RS02495	COG1403	HNH endonuclease
I5M56_RS02560	COG1802	Transcriptional regulator
I5M56_RS02560	COG4626	Terminase
I5M56_RS02660	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I5M56_RS02670	COG1418	mRNA catabolic process
I5M56_RS02675	COG0270	DNA (cytosine-5-)-methyltransferase activity
I5M56_RS02680	COG3727	T/G mismatch-specific endonuclease activity
I5M56_RS02685	COG0697	spore germination
I5M56_RS02690	COG2354	Protein conserved in bacteria
I5M56_RS02720	COG0366	Alpha amylase catalytic
I5M56_RS02725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M56_RS02735	COG0765	amino acid transport
I5M56_RS02740	COG1126	abc transporter atp-binding protein
I5M56_RS02745	COG2197	response regulator
I5M56_RS02755	COG2197	response regulator
I5M56_RS02810	COG3318	Belongs to the UPF0149 family
I5M56_RS02810	COG3012	SEC-C Motif Domain Protein
I5M56_RS02815	COG0814	amino acid
I5M56_RS02825	COG1528	Iron-storage protein
I5M56_RS02840	COG0477	Major facilitator Superfamily
I5M56_RS02850	COG2211	Major facilitator Superfamily
I5M56_RS02850	COG2211	Major facilitator Superfamily
I5M56_RS02860	COG1528	Iron-storage protein
I5M56_RS02865	COG1879	ABC-type sugar transport system periplasmic component
I5M56_RS02875	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M56_RS02900	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I5M56_RS02910	COG3102	Protein conserved in bacteria
I5M56_RS02930	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I5M56_RS02935	COG1801	Protein of unknown function DUF72
I5M56_RS02940	COG1335	isochorismatase
I5M56_RS02950	COG0494	nUDIX hydrolase
I5M56_RS02975	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5M56_RS02985	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I5M56_RS02990	COG0739	heme binding
I5M56_RS02995	COG1560	Kdo2-lipid A biosynthetic process
I5M56_RS03015	COG3493	citrate carrier protein
I5M56_RS03025	COG1737	Transcriptional regulator
I5M56_RS03035	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I5M56_RS03040	COG0129	dihydroxy-acid dehydratase activity
I5M56_RS03045	COG0800	Aldolase
I5M56_RS03055	COG3141	response to X-ray
I5M56_RS03060	COG2979	Protein of unknown function (DUF533)
I5M56_RS03065	COG1770	oligopeptidase
I5M56_RS03070	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I5M56_RS03080	COG2372	response to copper ion
I5M56_RS03085	COG1276	copper resistance
I5M56_RS03100	COG2990	Protein conserved in bacteria
I5M56_RS03125	COG3008	intermembrane lipid transfer
I5M56_RS03130	COG2995	paraquat-inducible protein a
I5M56_RS03135	COG1956	GAF domain-containing protein
I5M56_RS03155	COG2814	Major facilitator Superfamily
I5M56_RS03160	COG1414	Transcriptional regulator
I5M56_RS03190	COG0768	penicillin binding
I5M56_RS03195	COG2226	methyltransferase
I5M56_RS03210	COG3716	PTS system mannose fructose sorbose family IID component
I5M56_RS03215	COG3715	PTS system
I5M56_RS03220	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M56_RS03220	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5M56_RS03225	COG1253	flavin adenine dinucleotide binding
I5M56_RS03230	COG2200	EAL domain
I5M56_RS03235	COG1760	l-serine dehydratase
I5M56_RS03255	COG0251	oxidation-reduction process
I5M56_RS03260	COG1199	ATP-dependent helicase activity
I5M56_RS03270	COG3065	identical protein binding
I5M56_RS03280	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I5M56_RS03290	COG2894	cell division
I5M56_RS03305	COG0179	Fumarylacetoacetate (FAA) hydrolase
I5M56_RS03335	COG2719	SpoVR family
I5M56_RS03360	COG1619	proteins homologs of microcin C7 resistance protein MccF
I5M56_RS03380	COG4774	siderophore transport
I5M56_RS03390	COG2211	Major facilitator Superfamily
I5M56_RS03400	COG2308	Evidence 4 Homologs of previously reported genes of
I5M56_RS03430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5M56_RS03440	COG1174	glycine betaine transport
I5M56_RS03460	COG0583	DNA-binding transcription factor activity
I5M56_RS03465	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I5M56_RS03480	COG1882	Formate acetyltransferase
I5M56_RS03515	COG0583	DNA-binding transcription factor activity
I5M56_RS03545	COG0583	DNA-binding transcription factor activity
I5M56_RS03560	COG3122	Protein conserved in bacteria
I5M56_RS03585	COG0012	GTP binding
I5M56_RS03605	COG0659	secondary active sulfate transmembrane transporter activity
I5M56_RS03635	COG2890	protein-(glutamine-N5) methyltransferase activity
I5M56_RS03655	COG0387	Pfam Sodium calcium exchanger
I5M56_RS03660	COG4572	Cation transport regulator
I5M56_RS03665	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I5M56_RS03675	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I5M56_RS03680	COG3707	response regulator
I5M56_RS03685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5M56_RS03695	COG1116	anion transmembrane transporter activity
I5M56_RS03700	COG2146	nitrite reductase [NAD(P)H] activity
I5M56_RS03700	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I5M56_RS03705	COG0243	molybdopterin cofactor binding
I5M56_RS03710	COG4932	domain protein
I5M56_RS03715	COG2197	response regulator
I5M56_RS03720	COG3850	Histidine kinase
I5M56_RS03725	COG2223	nitrite transmembrane transporter activity
I5M56_RS03730	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I5M56_RS03735	COG1140	nitrate reductase beta subunit
I5M56_RS03740	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I5M56_RS03745	COG2181	nitrate reductase activity
I5M56_RS03755	COG1522	sequence-specific DNA binding
I5M56_RS03780	COG0788	formyltetrahydrofolate deformylase activity
I5M56_RS03790	COG1752	Esterase of the alpha-beta hydrolase superfamily
I5M56_RS03795	COG0745	RESPONSE REGULATOR receiver
I5M56_RS03800	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I5M56_RS03805	COG2916	Histone family protein nucleoid-structuring protein H-NS
I5M56_RS03810	COG1435	thymidine kinase activity
I5M56_RS03815	COG1454	alcohol dehydrogenase
I5M56_RS03815	COG1012	belongs to the aldehyde dehydrogenase family
I5M56_RS03825	COG2095	MarC family integral membrane protein
I5M56_RS03830	COG4166	transmembrane transport
I5M56_RS03835	COG0601	transmembrane transport
I5M56_RS03840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5M56_RS03845	COG0444	Belongs to the ABC transporter superfamily
I5M56_RS03855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5M56_RS03875	COG2353	YceI-like domain
I5M56_RS03880	COG2350	Protein conserved in bacteria
I5M56_RS03890	COG3001	Fructosamine kinase
I5M56_RS03900	COG1105	Belongs to the carbohydrate kinase PfkB family
I5M56_RS03905	COG3137	Salt-induced outer membrane protein
I5M56_RS03945	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I5M56_RS03945	COG0072	phenylalanine-tRNA ligase activity
I5M56_RS03965	COG0583	DNA-binding transcription factor activity
I5M56_RS03985	COG0386	Belongs to the glutathione peroxidase family
I5M56_RS03995	COG0791	NLP P60 protein
I5M56_RS04005	COG4256	Hemin uptake protein
I5M56_RS04010	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I5M56_RS04025	COG0574	Belongs to the PEP-utilizing enzyme family
I5M56_RS04025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I5M56_RS04035	COG0628	permease
I5M56_RS04040	COG0277	FAD linked oxidase domain protein
I5M56_RS04040	COG0247	lactate metabolic process
I5M56_RS04045	COG2050	protein possibly involved in aromatic compounds catabolism
I5M56_RS04050	COG2261	transglycosylase associated protein
I5M56_RS04065	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I5M56_RS04075	COG1120	ATPase activity
I5M56_RS04080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M56_RS04090	COG0583	DNA-binding transcription factor activity
I5M56_RS04115	COG1304	FMN binding
I5M56_RS04130	COG0316	Belongs to the HesB IscA family
I5M56_RS04135	COG0719	Fe-S assembly protein
I5M56_RS04140	COG0396	ATPase activity
I5M56_RS04145	COG0719	Fe-S assembly protein
I5M56_RS04160	COG1376	ErfK ybiS ycfS ynhG family protein
I5M56_RS04185	COG1309	transcriptional regulator
I5M56_RS04190	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I5M56_RS04190	COG1082	Xylose isomerase domain protein TIM barrel
I5M56_RS04195	COG2271	Major facilitator Superfamily
I5M56_RS04200	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I5M56_RS04210	COG1120	ATPase activity
I5M56_RS04215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M56_RS04220	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I5M56_RS04225	COG1414	Transcriptional regulator
I5M56_RS04260	COG2814	Major facilitator Superfamily
I5M56_RS04280	COG0583	DNA-binding transcription factor activity
I5M56_RS04285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5M56_RS04305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5M56_RS04310	COG1116	anion transmembrane transporter activity
I5M56_RS04315	COG4774	siderophore transport
I5M56_RS04320	COG1120	ATPase activity
I5M56_RS04325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M56_RS04330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M56_RS04335	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I5M56_RS04350	COG0765	amino acid transport
I5M56_RS04355	COG1126	abc transporter atp-binding protein
I5M56_RS04385	COG3383	formate dehydrogenase (NAD+) activity
I5M56_RS04390	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I5M56_RS04400	COG1175	transmembrane transport
I5M56_RS04430	COG4133	protoheme IX ABC transporter activity
I5M56_RS04435	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I5M56_RS04440	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I5M56_RS04455	COG1138	Cytochrome C-type biogenesis protein
I5M56_RS04465	COG4235	cytochrome complex assembly
I5M56_RS04465	COG3088	subunit of a heme lyase
I5M56_RS04485	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I5M56_RS04500	COG3850	Histidine kinase
I5M56_RS04500	COG5002	protein histidine kinase activity
I5M56_RS04505	COG0745	RESPONSE REGULATOR receiver
I5M56_RS04520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5M56_RS04550	COG1028	Short-chain dehydrogenase reductase Sdr
I5M56_RS04555	COG2610	gluconate transmembrane transporter activity
I5M56_RS04560	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5M56_RS04570	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I5M56_RS04580	COG0583	DNA-binding transcription factor activity
I5M56_RS04610	COG2814	Major facilitator Superfamily
I5M56_RS04645	COG0277	FAD linked oxidase domain protein
I5M56_RS04650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5M56_RS04675	COG0402	S-adenosylhomocysteine deaminase activity
I5M56_RS04730	COG1979	alcohol dehydrogenase
I5M56_RS04740	COG0583	DNA-binding transcription factor activity
I5M56_RS04760	COG4608	Belongs to the ABC transporter superfamily
I5M56_RS04765	COG0444	Belongs to the ABC transporter superfamily
I5M56_RS04795	COG2011	ABC-type metal ion transport system permease component
I5M56_RS04810	COG0346	lactoylglutathione lyase activity
I5M56_RS04815	COG1349	DNA-binding transcription factor activity
I5M56_RS04830	COG1028	Short-chain dehydrogenase reductase Sdr
I5M56_RS04830	COG3321	synthase
I5M56_RS04830	COG0604	alcohol dehydrogenase
I5M56_RS04855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5M56_RS04875	COG0300	oxidoreductase activity
I5M56_RS04910	COG0307	riboflavin synthase, alpha
I5M56_RS04915	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I5M56_RS04920	COG2814	Major facilitator Superfamily
I5M56_RS04925	COG0583	DNA-binding transcription factor activity
I5M56_RS04940	COG2814	Major facilitator Superfamily
I5M56_RS04955	COG0791	NLP P60 protein
I5M56_RS04960	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I5M56_RS04970	COG0346	lactoylglutathione lyase activity
I5M56_RS04975	COG1902	pentaerythritol trinitrate reductase activity
I5M56_RS04980	COG1309	transcriptional regulator
I5M56_RS04985	COG3313	Fe-S protein
I5M56_RS04990	COG4989	oxidoreductase activity
I5M56_RS04995	COG2032	superoxide dismutase activity
I5M56_RS05000	COG1289	transmembrane transporter activity
I5M56_RS05005	COG1566	PFAM secretion protein HlyD family protein
I5M56_RS05020	COG3706	GGDEF domain
I5M56_RS05035	COG3895	Periplasmic Protein
I5M56_RS05050	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I5M56_RS05055	COG0625	glutathione transferase activity
I5M56_RS05065	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I5M56_RS05075	COG4659	FMN binding
I5M56_RS05110	COG2723	6-phospho-beta-galactosidase activity
I5M56_RS05120	COG0673	inositol 2-dehydrogenase activity
I5M56_RS05130	COG2814	Major facilitator Superfamily
I5M56_RS05150	COG3038	cytochrome b561
I5M56_RS05170	COG0583	DNA-binding transcription factor activity
I5M56_RS05175	COG3485	protocatechuate 3,4-dioxygenase
I5M56_RS05180	COG3485	protocatechuate 3,4-dioxygenase
I5M56_RS05185	COG5383	Protein conserved in bacteria
I5M56_RS05190	COG2272	Belongs to the type-B carboxylesterase lipase family
I5M56_RS05200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5M56_RS05205	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I5M56_RS05210	COG1275	C4-dicarboxylate transporter malic acid transport protein
I5M56_RS05215	COG0500	methyltransferase
I5M56_RS05230	COG3708	Transcriptional regulator
I5M56_RS05230	COG2207	Transcriptional regulator
I5M56_RS05235	COG3135	benzoate transporter
I5M56_RS05240	COG1396	sequence-specific DNA binding
I5M56_RS05250	COG0826	peptidase U32
I5M56_RS05270	COG1294	oxidase, subunit
I5M56_RS05275	COG1271	oxidase subunit
I5M56_RS05280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5M56_RS05285	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I5M56_RS05290	COG3842	ATPase activity
I5M56_RS05295	COG1176	ABC-type spermidine putrescine transport system, permease component I
I5M56_RS05300	COG1177	transmembrane transport
I5M56_RS05305	COG1012	belongs to the aldehyde dehydrogenase family
I5M56_RS05340	COG0747	negative chemotaxis
I5M56_RS05350	COG3238	Protein conserved in bacteria
I5M56_RS05355	COG1247	-acetyltransferase
I5M56_RS05365	COG2130	NADP-dependent
I5M56_RS05375	COG3691	Protein conserved in bacteria
I5M56_RS05380	COG4772	TonB-dependent receptor
I5M56_RS05400	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I5M56_RS05405	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I5M56_RS05410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5M56_RS05415	COG1473	amidohydrolase
I5M56_RS05420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5M56_RS05425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M56_RS05435	COG0765	amino acid transport
I5M56_RS05440	COG1126	abc transporter atp-binding protein
I5M56_RS05450	COG0625	glutathione transferase activity
I5M56_RS05465	COG2211	Major facilitator Superfamily
I5M56_RS05480	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I5M56_RS05485	COG3842	ATPase activity
I5M56_RS05490	COG1840	ABC-type Fe3 transport system, periplasmic component
I5M56_RS05495	COG1178	ABC-type Fe3 transport system permease component
I5M56_RS05500	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I5M56_RS05505	COG2181	nitrate reductase activity
I5M56_RS05510	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I5M56_RS05515	COG1140	nitrate reductase beta subunit
I5M56_RS05520	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I5M56_RS05540	COG1414	Transcriptional regulator
I5M56_RS05545	COG4948	Mandelate Racemase Muconate Lactonizing
I5M56_RS05550	COG4829	muconolactone delta-isomerase
I5M56_RS05555	COG3485	protocatechuate 3,4-dioxygenase
I5M56_RS05580	COG0697	spore germination
I5M56_RS05590	COG0437	4 iron, 4 sulfur cluster binding
I5M56_RS05595	COG2864	formate dehydrogenase
I5M56_RS05610	COG2326	polyphosphate kinase activity
I5M56_RS05620	COG2814	Major facilitator Superfamily
I5M56_RS05630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5M56_RS05640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5M56_RS05650	COG0747	negative chemotaxis
I5M56_RS05655	COG1064	alcohol dehydrogenase
I5M56_RS05670	COG0488	(ABC) transporter
I5M56_RS05715	COG1028	Short-chain dehydrogenase reductase Sdr
I5M56_RS05720	COG3729	General stress protein
I5M56_RS05730	COG3685	Protein conserved in bacteria
I5M56_RS05740	COG0366	Alpha amylase catalytic
I5M56_RS05750	COG2323	membrane
I5M56_RS05760	COG3111	PFAM Bacterial OB fold (BOF) protein
I5M56_RS05770	COG1764	response to oxidative stress
I5M56_RS05785	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I5M56_RS05790	COG3781	membrane
I5M56_RS05795	COG0243	molybdopterin cofactor binding
I5M56_RS05800	COG0583	DNA-binding transcription factor activity
I5M56_RS05805	COG2814	Major facilitator Superfamily
I5M56_RS05810	COG1285	pathogenesis
I5M56_RS05815	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I5M56_RS05835	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I5M56_RS05835	COG0519	Catalyzes the synthesis of GMP from XMP
I5M56_RS05875	COG0596	Alpha beta hydrolase
I5M56_RS05885	COG2205	protein histidine kinase activity
I5M56_RS05895	COG0583	DNA-binding transcription factor activity
I5M56_RS05900	COG0076	glutamate decarboxylase activity
I5M56_RS05905	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I5M56_RS05910	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5M56_RS05915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5M56_RS05920	COG1116	anion transmembrane transporter activity
I5M56_RS05925	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I5M56_RS05945	COG0673	inositol 2-dehydrogenase activity
I5M56_RS05955	COG1609	Transcriptional regulator
I5M56_RS05960	COG3706	GGDEF domain
I5M56_RS05970	COG0402	S-adenosylhomocysteine deaminase activity
I5M56_RS05975	COG1953	Uracil, thiamine, allantoin
I5M56_RS06010	COG0406	alpha-ribazole phosphatase activity
I5M56_RS06025	COG0583	DNA-binding transcription factor activity
I5M56_RS06040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I5M56_RS06065	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I5M56_RS06110	COG0765	amino acid transport
I5M56_RS06120	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I5M56_RS06130	COG2070	2-Nitropropane dioxygenase
I5M56_RS06135	COG0583	DNA-binding transcription factor activity
I5M56_RS06145	COG1902	pentaerythritol trinitrate reductase activity
I5M56_RS06150	COG4529	Protein conserved in bacteria
I5M56_RS06155	COG0477	Major facilitator Superfamily
I5M56_RS06185	COG2223	nitrite transmembrane transporter activity
I5M56_RS06200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5M56_RS06200	COG1116	anion transmembrane transporter activity
I5M56_RS06210	COG3665	Urea carboxylase-associated protein
I5M56_RS06215	COG0439	Biotin carboxylase
I5M56_RS06305	COG5002	protein histidine kinase activity
I5M56_RS06340	COG2186	Transcriptional regulator
I5M56_RS06355	COG2814	Major facilitator Superfamily
I5M56_RS06360	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M56_RS06360	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M56_RS06375	COG2819	hydrolase of the alpha beta superfamily
I5M56_RS06380	COG5001	Diguanylate cyclase
I5M56_RS06380	COG3300	MHYT domain
I5M56_RS06400	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I5M56_RS06420	COG1649	PFAM Uncharacterised BCR, COG1649
I5M56_RS06425	COG3550	peptidyl-serine autophosphorylation
I5M56_RS06430	COG1396	sequence-specific DNA binding
I5M56_RS06435	COG2351	hydroxyisourate hydrolase activity
I5M56_RS06440	COG3648	Uricase
I5M56_RS06440	COG3195	allantoin biosynthetic process
I5M56_RS06445	COG2233	PERMEase
I5M56_RS06475	COG2207	Transcriptional regulator
I5M56_RS06490	COG4628	conserved protein (DUF2132)
I5M56_RS06510	COG2011	ABC-type metal ion transport system permease component
I5M56_RS06515	COG2070	2-Nitropropane dioxygenase
I5M56_RS06570	COG2199	diguanylate cyclase activity
I5M56_RS06585	COG1012	belongs to the aldehyde dehydrogenase family
I5M56_RS06590	COG0583	DNA-binding transcription factor activity
I5M56_RS06600	COG0039	L-malate dehydrogenase activity
I5M56_RS06630	COG4977	sequence-specific DNA binding
I5M56_RS06640	COG0697	spore germination
I5M56_RS06645	COG2814	Major facilitator Superfamily
I5M56_RS06680	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I5M56_RS06715	COG2223	nitrite transmembrane transporter activity
I5M56_RS06735	COG1349	DNA-binding transcription factor activity
I5M56_RS06740	COG2084	Dehydrogenase
I5M56_RS06745	COG3395	kinase activity
I5M56_RS06750	COG0235	Class ii aldolase
I5M56_RS06755	COG3622	Belongs to the hyi family
I5M56_RS06760	COG2610	gluconate transmembrane transporter activity
I5M56_RS06765	COG2207	Transcriptional regulator
I5M56_RS06765	COG3708	Transcriptional regulator
I5M56_RS06780	COG2200	EAL domain
I5M56_RS06785	COG1546	Belongs to the CinA family
I5M56_RS06790	COG0071	Belongs to the small heat shock protein (HSP20) family
I5M56_RS06800	COG2135	peptidase activity
I5M56_RS06805	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5M56_RS06825	COG4221	oxidoreductase activity
I5M56_RS06830	COG1802	Transcriptional regulator
I5M56_RS06840	COG0246	Mannitol dehydrogenase
I5M56_RS06845	COG2271	Major facilitator Superfamily
I5M56_RS06860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5M56_RS06875	COG0243	molybdopterin cofactor binding
I5M56_RS06880	COG0437	4 iron, 4 sulfur cluster binding
I5M56_RS06885	COG3302	dmso reductase anchor subunit
I5M56_RS06900	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I5M56_RS06905	COG1940	carbohydrate kinase activity
I5M56_RS06910	COG0583	DNA-binding transcription factor activity
I5M56_RS06915	COG2814	Major facilitator Superfamily
I5M56_RS06920	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I5M56_RS06930	COG3591	Belongs to the peptidase S1B family
I5M56_RS06950	COG0628	permease
I5M56_RS06980	COG0679	Auxin Efflux Carrier
I5M56_RS06990	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I5M56_RS07015	COG3290	protein histidine kinase activity
I5M56_RS07020	COG4565	transcriptional regulatory protein
I5M56_RS07030	COG1053	succinate dehydrogenase
I5M56_RS07040	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I5M56_RS07040	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I5M56_RS07050	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5M56_RS07055	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I5M56_RS07065	COG0183	Belongs to the thiolase family
I5M56_RS07070	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I5M56_RS07080	COG1414	Transcriptional regulator
I5M56_RS07085	COG2840	Smr protein MutS2
I5M56_RS07090	COG0583	DNA-binding transcription factor activity
I5M56_RS07100	COG1473	amidohydrolase
I5M56_RS07105	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I5M56_RS07120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5M56_RS07135	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I5M56_RS07140	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I5M56_RS07155	COG0531	amino acid
I5M56_RS07165	COG3136	membrane protein required for alginate biosynthesis
I5M56_RS07170	COG0745	RESPONSE REGULATOR receiver
I5M56_RS07180	COG2205	protein histidine kinase activity
I5M56_RS07190	COG0114	fumarate hydratase activity
I5M56_RS07195	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I5M56_RS07195	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I5M56_RS07200	COG1482	cell wall glycoprotein biosynthetic process
I5M56_RS07205	COG5339	Protein conserved in bacteria
I5M56_RS07210	COG1609	Transcriptional regulator
I5M56_RS07215	COG1263	PTS System
I5M56_RS07215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5M56_RS07220	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I5M56_RS07250	COG0425	Belongs to the sulfur carrier protein TusA family
I5M56_RS07255	COG5562	phage envelope protein
I5M56_RS07260	COG0401	homolog of Blt101
I5M56_RS07265	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I5M56_RS07270	COG1012	belongs to the aldehyde dehydrogenase family
I5M56_RS07280	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I5M56_RS07285	COG0477	Major facilitator Superfamily
I5M56_RS07290	COG1113	amino acid transport
I5M56_RS07295	COG2988	succinylglutamate desuccinylase activity
I5M56_RS07300	COG3724	N-succinylarginine dihydrolase activity
I5M56_RS07305	COG1012	belongs to the aldehyde dehydrogenase family
I5M56_RS07310	COG3138	arginine N-succinyltransferase
I5M56_RS07315	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I5M56_RS07325	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I5M56_RS07340	COG0183	Belongs to the thiolase family
I5M56_RS07350	COG0667	Aldo Keto reductase
I5M56_RS07355	COG2814	Major facilitator Superfamily
I5M56_RS07360	COG0667	Aldo Keto reductase
I5M56_RS07365	COG0583	DNA-binding transcription factor activity
I5M56_RS07390	COG4122	O-methyltransferase activity
I5M56_RS07400	COG1643	Atp-dependent helicase
I5M56_RS07415	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I5M56_RS07420	COG3327	negative regulation of DNA-templated transcription, initiation
I5M56_RS07425	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I5M56_RS07430	COG0183	Belongs to the thiolase family
I5M56_RS07435	COG2050	protein possibly involved in aromatic compounds catabolism
I5M56_RS07440	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5M56_RS07445	COG1024	Enoyl-CoA hydratase
I5M56_RS07450	COG1024	Enoyl-CoA hydratase
I5M56_RS07455	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5M56_RS07460	COG2151	metal-sulfur cluster biosynthetic enzyme
I5M56_RS07465	COG3396	Phenylacetate-CoA oxygenase
I5M56_RS07470	COG3460	Phenylacetate-CoA oxygenase
I5M56_RS07475	COG3396	Phenylacetate-CoA oxygenase
I5M56_RS07480	COG2030	dehydratase
I5M56_RS07480	COG1012	belongs to the aldehyde dehydrogenase family
I5M56_RS07520	COG2072	flavoprotein involved in K transport
I5M56_RS07525	COG0583	DNA-binding transcription factor activity
I5M56_RS07530	COG1126	abc transporter atp-binding protein
I5M56_RS07540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M56_RS07555	COG1012	belongs to the aldehyde dehydrogenase family
I5M56_RS07560	COG2207	Transcriptional regulator
I5M56_RS07565	COG3784	Protein of unknown function (DUF1318)
I5M56_RS07575	COG2911	Protein conserved in bacteria
I5M56_RS07580	COG0586	Pfam SNARE associated Golgi protein
I5M56_RS07585	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I5M56_RS07590	COG3187	Heat shock protein
I5M56_RS07595	COG3042	response to heat
I5M56_RS07600	COG0674	pyruvate-flavodoxin oxidoreductase activity
I5M56_RS07600	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I5M56_RS07600	COG1013	pyruvate-flavodoxin oxidoreductase activity
I5M56_RS07600	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I5M56_RS07605	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I5M56_RS07620	COG0589	response to stress
I5M56_RS07645	COG0513	Belongs to the DEAD box helicase family
I5M56_RS07655	COG1349	DNA-binding transcription factor activity
I5M56_RS07660	COG0673	inositol 2-dehydrogenase activity
I5M56_RS07675	COG1113	amino acid transport
I5M56_RS07680	COG1522	sequence-specific DNA binding
I5M56_RS07690	COG1448	Aminotransferase
I5M56_RS07695	COG2011	ABC-type metal ion transport system permease component
I5M56_RS07700	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I5M56_RS07710	COG0436	Aminotransferase
I5M56_RS07735	COG0583	DNA-binding transcription factor activity
I5M56_RS07755	COG1028	Short-chain dehydrogenase reductase Sdr
I5M56_RS07760	COG1309	transcriptional regulator
I5M56_RS07765	COG1028	Short-chain dehydrogenase reductase Sdr
I5M56_RS07770	COG0693	protein deglycase activity
I5M56_RS07840	COG5002	protein histidine kinase activity
I5M56_RS07840	COG2205	protein histidine kinase activity
I5M56_RS07840	COG0784	Response regulator, receiver
I5M56_RS07845	COG3250	beta-galactosidase activity
I5M56_RS07850	COG0656	L-ascorbic acid biosynthetic process
I5M56_RS07870	COG4166	transmembrane transport
I5M56_RS07880	COG2866	Carboxypeptidase
I5M56_RS07885	COG4948	Mandelate Racemase Muconate Lactonizing
I5M56_RS07890	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I5M56_RS07895	COG3180	Ammonia monooxygenase
I5M56_RS07910	COG3106	COG3106 Predicted ATPase
I5M56_RS07920	COG1983	PspC domain protein
I5M56_RS07930	COG1842	Phage shock protein A
I5M56_RS07935	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I5M56_RS07945	COG1473	amidohydrolase
I5M56_RS07960	COG0702	epimerase
I5M56_RS07975	COG4171	peptide transport system, permease
I5M56_RS07990	COG2986	histidine ammonia-lyase
I5M56_RS08025	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5M56_RS08025	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5M56_RS08040	COG1349	DNA-binding transcription factor activity
I5M56_RS08050	COG0023	Translation Initiation Factor
I5M56_RS08060	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I5M56_RS08065	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I5M56_RS08070	COG0671	phosphoesterase, PA-phosphatase related
I5M56_RS08080	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I5M56_RS08105	COG0616	signal peptide processing
I5M56_RS08110	COG1028	Short-chain dehydrogenase reductase Sdr
I5M56_RS08115	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I5M56_RS08125	COG0583	DNA-binding transcription factor activity
I5M56_RS08135	COG0009	L-threonylcarbamoyladenylate synthase
I5M56_RS08145	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I5M56_RS08150	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I5M56_RS08150	COG0512	Glutamine amidotransferase of anthranilate synthase
I5M56_RS08155	COG0135	phosphoribosylanthranilate isomerase activity
I5M56_RS08155	COG0134	indole-3-glycerol-phosphate synthase activity
I5M56_RS08185	COG4774	siderophore transport
I5M56_RS08195	COG3047	cAMP biosynthetic process
I5M56_RS08200	COG0727	PFAM Uncharacterised protein family (UPF0153)
I5M56_RS08230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5M56_RS08235	COG1028	Short-chain dehydrogenase reductase Sdr
I5M56_RS08240	COG1988	membrane-bound metal-dependent
I5M56_RS08245	COG1823	symporter activity
I5M56_RS08255	COG0753	catalase activity
I5M56_RS08265	COG1486	melibiose metabolic process
I5M56_RS08270	COG2169	Transcriptional regulator
I5M56_RS08270	COG1917	Cupin 2, conserved barrel domain protein
I5M56_RS08275	COG1447	Phosphotransferase system cellobiose-specific component IIA
I5M56_RS08280	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M56_RS08290	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M56_RS08295	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I5M56_RS08305	COG0322	excinuclease ABC activity
I5M56_RS08310	COG3678	ATP-independent chaperone mediated protein folding
I5M56_RS08320	COG3724	N-succinylarginine dihydrolase activity
I5M56_RS08330	COG3138	arginine N-succinyltransferase
I5M56_RS08340	COG0708	Exodeoxyribonuclease III
I5M56_RS08345	COG0398	Pfam SNARE associated Golgi protein
I5M56_RS08350	COG0398	Pfam SNARE associated Golgi protein
I5M56_RS08355	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5M56_RS08360	COG4134	Bacterial extracellular solute-binding protein
I5M56_RS08365	COG4135	transport system, permease component
I5M56_RS08370	COG4136	ATPase activity
I5M56_RS08375	COG2897	thiosulfate sulfurtransferase activity
I5M56_RS08380	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I5M56_RS08385	COG0494	nUDIX hydrolase
I5M56_RS08390	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I5M56_RS08395	COG0604	alcohol dehydrogenase
I5M56_RS08395	COG1028	Short-chain dehydrogenase reductase Sdr
I5M56_RS08395	COG3321	synthase
I5M56_RS08400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I5M56_RS08405	COG0709	Synthesizes selenophosphate from selenide and ATP
I5M56_RS08415	COG0778	Nitroreductase
I5M56_RS08420	COG0616	signal peptide processing
I5M56_RS08425	COG0252	asparaginase activity
I5M56_RS08430	COG1335	isochorismatase
I5M56_RS08445	COG3139	Protein of unknown function (DUF1315)
I5M56_RS08465	COG0656	L-ascorbic acid biosynthetic process
I5M56_RS08470	COG3713	MltA-interacting MipA family protein
I5M56_RS08475	COG2766	serine protein kinase
I5M56_RS08485	COG0386	Belongs to the glutathione peroxidase family
I5M56_RS08520	COG1126	abc transporter atp-binding protein
I5M56_RS08525	COG0765	amino acid transport
I5M56_RS08530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M56_RS08540	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I5M56_RS08550	COG0583	DNA-binding transcription factor activity
I5M56_RS08555	COG1902	pentaerythritol trinitrate reductase activity
I5M56_RS08565	COG1028	Short-chain dehydrogenase reductase Sdr
I5M56_RS08570	COG0583	DNA-binding transcription factor activity
I5M56_RS08575	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I5M56_RS08590	COG0859	PFAM glycosyl transferase family 9
I5M56_RS08595	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I5M56_RS08605	COG2207	Transcriptional regulator
I5M56_RS08610	COG2807	transmembrane transport
I5M56_RS08615	COG0504	CTP synthase activity
I5M56_RS08620	COG1683	Conserved Protein
I5M56_RS08625	COG3189	MarR family transcriptional regulator
I5M56_RS08630	COG3042	response to heat
I5M56_RS08635	COG2203	Gaf domain
I5M56_RS08635	COG2199	diguanylate cyclase activity
I5M56_RS08655	COG3182	Iron-regulated membrane protein
I5M56_RS08665	COG1560	Kdo2-lipid A biosynthetic process
I5M56_RS08675	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I5M56_RS08680	COG3706	GGDEF domain
I5M56_RS08685	COG0583	DNA-binding transcription factor activity
I5M56_RS08690	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I5M56_RS08700	COG2200	EAL domain
I5M56_RS08700	COG2771	luxR family
I5M56_RS08725	COG1294	oxidase, subunit
I5M56_RS08730	COG1271	oxidase subunit
I5M56_RS08735	COG3546	catalase activity
I5M56_RS08740	COG3685	Protein conserved in bacteria
I5M56_RS08745	COG3685	Protein conserved in bacteria
I5M56_RS08750	COG3729	General stress protein
I5M56_RS08755	COG1063	alcohol dehydrogenase
I5M56_RS08760	COG3813	Protein conserved in bacteria
I5M56_RS08795	COG0538	isocitrate dehydrogenase activity
I5M56_RS08895	COG0616	signal peptide processing
I5M56_RS08910	COG1802	Transcriptional regulator
I5M56_RS08910	COG4626	Terminase
I5M56_RS08955	COG3772	lysozyme
I5M56_RS08980	COG1403	HNH endonuclease
I5M56_RS09045	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I5M56_RS09055	COG0582	viral genome integration into host DNA
I5M56_RS09060	COG0538	isocitrate dehydrogenase activity
I5M56_RS09065	COG1187	pseudouridine synthase activity
I5M56_RS09085	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I5M56_RS09105	COG2205	protein histidine kinase activity
I5M56_RS09110	COG2850	peptidyl-arginine hydroxylation
I5M56_RS09115	COG1943	Transposase
I5M56_RS09135	COG1177	transmembrane transport
I5M56_RS09150	COG0318	PFAM AMP-dependent synthetase and ligase
I5M56_RS09160	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I5M56_RS09170	COG4591	ABC-type transport system involved in lipoprotein release permease component
I5M56_RS09180	COG4591	ABC-type transport system involved in lipoprotein release permease component
I5M56_RS09190	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I5M56_RS09195	COG1388	LysM domain
I5M56_RS09195	COG1376	ErfK ybiS ycfS ynhG family protein
I5M56_RS09210	COG1309	transcriptional regulator
I5M56_RS09225	COG3134	Outer membrane lipoprotein
I5M56_RS09230	COG1252	NADH dehydrogenase
I5M56_RS09255	COG5633	Lipoprotein
I5M56_RS09260	COG0537	adenosine 5'-monophosphoramidase activity
I5M56_RS09270	COG0084	hydrolase, TatD family'
I5M56_RS09275	COG0470	DNA polymerase III
I5M56_RS09285	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I5M56_RS09290	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I5M56_RS09295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I5M56_RS09310	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I5M56_RS09330	COG1399	metal-binding, possibly nucleic acid-binding protein
I5M56_RS09350	COG1530	ribonuclease E activity
I5M56_RS09355	COG0583	DNA-binding transcription factor activity
I5M56_RS09360	COG2814	Major facilitator Superfamily
I5M56_RS09365	COG0728	peptidoglycan biosynthetic process
I5M56_RS09380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5M56_RS09425	COG1560	Kdo2-lipid A biosynthetic process
I5M56_RS09440	COG5645	(Lipo)protein
I5M56_RS09475	COG3381	protein complex oligomerization
I5M56_RS09500	COG0583	DNA-binding transcription factor activity
I5M56_RS09510	COG1335	isochorismatase
I5M56_RS09520	COG1702	phosphate starvation-inducible protein PhoH
I5M56_RS09540	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I5M56_RS09550	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I5M56_RS09565	COG1309	transcriptional regulator
I5M56_RS09600	COG2233	PERMEase
I5M56_RS09610	COG3729	General stress protein
I5M56_RS09655	COG1028	Short-chain dehydrogenase reductase Sdr
I5M56_RS09670	COG0531	amino acid
I5M56_RS09675	COG0174	glutamine synthetase
I5M56_RS09680	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I5M56_RS09685	COG1917	Cupin 2, conserved barrel domain protein
I5M56_RS09685	COG1396	sequence-specific DNA binding
I5M56_RS09690	COG1012	belongs to the aldehyde dehydrogenase family
I5M56_RS09695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5M56_RS09700	COG0583	DNA-binding transcription factor activity
I5M56_RS09705	COG0473	3-isopropylmalate dehydrogenase activity
I5M56_RS09710	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I5M56_RS09715	COG4638	Rieske (2fe-2S)
I5M56_RS09720	COG1012	belongs to the aldehyde dehydrogenase family
I5M56_RS09725	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5M56_RS09730	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M56_RS09730	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M56_RS09730	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I5M56_RS09735	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5M56_RS09740	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5M56_RS09745	COG1882	Formate acetyltransferase
I5M56_RS09750	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I5M56_RS09755	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5M56_RS09765	COG2207	Transcriptional regulator
I5M56_RS09770	COG3706	GGDEF domain
I5M56_RS09790	COG2200	EAL domain
I5M56_RS09815	COG0670	Belongs to the BI1 family
I5M56_RS09830	COG2207	Transcriptional regulator
I5M56_RS09835	COG1881	PFAM PEBP family protein
I5M56_RS09850	COG1832	CoA-binding protein
I5M56_RS09860	COG0210	DNA helicase
I5M56_RS09865	COG3304	Inner membrane component domain
I5M56_RS09870	COG1289	transmembrane transporter activity
I5M56_RS09875	COG3070	regulator of competence-specific genes
I5M56_RS09900	COG1067	ATP-dependent peptidase activity
I5M56_RS09910	COG3130	regulation of translation
I5M56_RS09915	COG3009	Protein conserved in bacteria
I5M56_RS09920	COG3008	intermembrane lipid transfer
I5M56_RS09920	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I5M56_RS09925	COG2995	paraquat-inducible protein a
I5M56_RS09930	COG0488	(ABC) transporter
I5M56_RS09940	COG0633	Ferredoxin
I5M56_RS09940	COG3217	Mosc domain protein beta barrel domain protein
I5M56_RS09955	COG0431	NADPH-dependent FMN reductase
I5M56_RS09960	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5M56_RS09965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5M56_RS09970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5M56_RS09980	COG0308	aminopeptidase N
I5M56_RS09995	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I5M56_RS10000	COG1448	Aminotransferase
I5M56_RS10005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5M56_RS10010	COG3108	Peptidase M15
I5M56_RS10015	COG2989	Protein conserved in bacteria
I5M56_RS10025	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I5M56_RS10035	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I5M56_RS10040	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I5M56_RS10045	COG3173	Aminoglycoside phosphotransferase
I5M56_RS10060	COG3214	Protein conserved in bacteria
I5M56_RS10075	COG2333	competence protein COMEC
I5M56_RS10075	COG0658	competence protein
I5M56_RS10085	COG0539	negative regulation of cytoplasmic translation
I5M56_RS10105	COG2323	membrane
I5M56_RS10110	COG1944	ATP diphosphatase activity
I5M56_RS10115	COG2116	formate transmembrane transporter activity
I5M56_RS10120	COG1882	Formate acetyltransferase
I5M56_RS10125	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I5M56_RS10130	COG0477	Major facilitator Superfamily
I5M56_RS10135	COG3302	dmso reductase anchor subunit
I5M56_RS10140	COG0437	4 iron, 4 sulfur cluster binding
I5M56_RS10145	COG0243	molybdopterin cofactor binding
I5M56_RS10155	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I5M56_RS10165	COG1178	ABC-type Fe3 transport system permease component
I5M56_RS10165	COG1674	ftsk spoiiie
I5M56_RS10175	COG0492	ferredoxin-NADP+ reductase activity
I5M56_RS10180	COG4988	ABC transporter
I5M56_RS10185	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I5M56_RS10200	COG0542	response to heat
I5M56_RS10210	COG1278	Cold shock
I5M56_RS10220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M56_RS10225	COG3593	DNA synthesis involved in DNA repair
I5M56_RS10235	COG2431	L-lysine efflux transmembrane transporter activity
I5M56_RS10245	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5M56_RS10255	COG0028	Belongs to the TPP enzyme family
I5M56_RS10260	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I5M56_RS10265	COG0702	epimerase
I5M56_RS10270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I5M56_RS10275	COG3023	N-Acetylmuramoyl-L-alanine amidase
I5M56_RS10280	COG4251	negative regulation of phosphorylation
I5M56_RS10280	COG2203	Gaf domain
I5M56_RS10280	COG3706	GGDEF domain
I5M56_RS10280	COG5001	Diguanylate cyclase
I5M56_RS10295	COG1126	abc transporter atp-binding protein
I5M56_RS10300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M56_RS10305	COG4215	(ABC) transporter
I5M56_RS10310	COG4160	amino acid transport
I5M56_RS10315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M56_RS10320	COG5002	protein histidine kinase activity
I5M56_RS10325	COG0745	RESPONSE REGULATOR receiver
I5M56_RS10340	COG1177	transmembrane transport
I5M56_RS10345	COG1176	ABC-type spermidine putrescine transport system, permease component I
I5M56_RS10350	COG3842	ATPase activity
I5M56_RS10355	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I5M56_RS10395	COG3226	Transcriptional regulator
I5M56_RS10400	COG0738	Major facilitator superfamily
I5M56_RS10405	COG0561	phosphatase activity
I5M56_RS10410	COG2814	Major facilitator Superfamily
I5M56_RS10415	COG0671	phosphoesterase, PA-phosphatase related
I5M56_RS10420	COG1349	DNA-binding transcription factor activity
I5M56_RS10425	COG1686	Belongs to the peptidase S11 family
I5M56_RS10430	COG0625	glutathione transferase activity
I5M56_RS10435	COG2133	pyrroloquinoline quinone binding
I5M56_RS10475	COG1446	asparaginase
I5M56_RS10480	COG0303	'Molybdopterin
I5M56_RS10485	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I5M56_RS10490	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I5M56_RS10495	COG1882	Formate acetyltransferase
I5M56_RS10500	COG0561	phosphatase activity
I5M56_RS10510	COG1609	Transcriptional regulator
I5M56_RS10515	COG2271	Major facilitator Superfamily
I5M56_RS10525	COG0488	(ABC) transporter
I5M56_RS10535	COG1376	ErfK ybiS ycfS ynhG family protein
I5M56_RS10540	COG2188	Transcriptional regulator
I5M56_RS10545	COG2723	6-phospho-beta-galactosidase activity
I5M56_RS10550	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I5M56_RS10555	COG1321	iron dependent repressor
I5M56_RS10565	COG2194	sulfuric ester hydrolase activity
I5M56_RS10570	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I5M56_RS10575	COG5006	permease, DMT superfamily
I5M56_RS10585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M56_RS10590	COG0765	amino acid transport
I5M56_RS10595	COG1126	abc transporter atp-binding protein
I5M56_RS10600	COG0668	transmembrane transport
I5M56_RS10610	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I5M56_RS10620	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I5M56_RS10630	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I5M56_RS10640	COG0513	Belongs to the DEAD box helicase family
I5M56_RS10645	COG3958	Transketolase
I5M56_RS10650	COG3959	Transketolase, thiamine diphosphate binding domain
I5M56_RS10655	COG1028	Short-chain dehydrogenase reductase Sdr
I5M56_RS10660	COG2271	Major facilitator Superfamily
I5M56_RS10670	COG0583	DNA-binding transcription factor activity
I5M56_RS10675	COG1309	transcriptional regulator
I5M56_RS10680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M56_RS10685	COG1131	(ABC) transporter
I5M56_RS10690	COG0842	Transport permease protein
I5M56_RS10695	COG0842	Transport permease protein
I5M56_RS10705	COG3568	Endonuclease Exonuclease Phosphatase
I5M56_RS10710	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5M56_RS10715	COG0392	lysyltransferase activity
I5M56_RS10720	COG0670	Belongs to the BI1 family
I5M56_RS10725	COG0314	molybdopterin synthase activity
I5M56_RS10730	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I5M56_RS10740	COG0521	Mo-molybdopterin cofactor biosynthetic process
I5M56_RS10760	COG0745	RESPONSE REGULATOR receiver
I5M56_RS10765	COG0642	Histidine kinase
I5M56_RS10790	COG2226	methyltransferase
I5M56_RS10805	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I5M56_RS10810	COG1881	PFAM PEBP family protein
I5M56_RS10850	COG4677	pectinesterase activity
I5M56_RS10860	COG0589	response to stress
I5M56_RS10865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M56_RS10900	COG0789	Transcriptional regulator
I5M56_RS10905	COG2200	EAL domain
I5M56_RS10930	COG0561	phosphatase activity
I5M56_RS10935	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I5M56_RS10940	COG4149	molybdate abc transporter
I5M56_RS10945	COG0725	ABC transporter, periplasmic molybdate-binding protein
I5M56_RS10955	COG2005	Transcriptional regulator
I5M56_RS10955	COG3585	molybdate ion transport
I5M56_RS10960	COG1119	ATPase activity
I5M56_RS10970	COG1085	galactose-1-phosphate uridylyltransferase
I5M56_RS10980	COG2017	converts alpha-aldose to the beta-anomer
I5M56_RS10990	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I5M56_RS11005	COG3201	nicotinamide mononucleotide transporter
I5M56_RS11010	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I5M56_RS11050	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I5M56_RS11055	COG2885	chlorophyll binding
I5M56_RS11065	COG3064	Membrane
I5M56_RS11065	COG3064	Membrane
I5M56_RS11070	COG0848	biopolymer transport protein
I5M56_RS11075	COG0811	peptide transport
I5M56_RS11080	COG0824	Thioesterase
I5M56_RS11085	COG3790	cyd operon protein YbgE
I5M56_RS11090	COG4890	Cyd operon protein YbgT
I5M56_RS11095	COG1294	oxidase, subunit
I5M56_RS11100	COG1271	oxidase subunit
I5M56_RS11105	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I5M56_RS11115	COG0508	dehydrogenase complex catalyzes the overall conversion of
I5M56_RS11120	COG0567	Dehydrogenase, E1 component
I5M56_RS11125	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I5M56_RS11130	COG1053	succinate dehydrogenase
I5M56_RS11135	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I5M56_RS11140	COG2009	succinate dehydrogenase
I5M56_RS11145	COG0372	Belongs to the citrate synthase family
I5M56_RS11165	COG1984	allophanate hydrolase subunit 2
I5M56_RS11170	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I5M56_RS11220	COG0745	RESPONSE REGULATOR receiver
I5M56_RS11230	COG0033	Phosphoglucomutase
I5M56_RS11240	COG0596	Alpha beta hydrolase
I5M56_RS11255	COG0735	belongs to the Fur family
I5M56_RS11260	COG0583	DNA-binding transcription factor activity
I5M56_RS11265	COG1053	succinate dehydrogenase
I5M56_RS11310	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I5M56_RS11315	COG1846	Transcriptional regulator
I5M56_RS11315	COG1940	carbohydrate kinase activity
I5M56_RS11320	COG0647	UMP catabolic process
I5M56_RS11325	COG0367	asparagine synthase
I5M56_RS11365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5M56_RS11375	COG1702	phosphate starvation-inducible protein PhoH
I5M56_RS11400	COG0765	amino acid transport
I5M56_RS11405	COG0765	amino acid transport
I5M56_RS11410	COG1126	abc transporter atp-binding protein
I5M56_RS11415	COG2831	hemolysin activation secretion protein
I5M56_RS11425	COG2888	peptidyl-tyrosine sulfation
I5M56_RS11440	COG1466	dna polymerase III delta subunit
I5M56_RS11455	COG0799	negative regulation of ribosome biogenesis
I5M56_RS11465	COG0768	penicillin binding
I5M56_RS11470	COG0772	Belongs to the SEDS family
I5M56_RS11475	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I5M56_RS11480	COG1686	Belongs to the peptidase S11 family
I5M56_RS11495	COG0583	DNA-binding transcription factor activity
I5M56_RS11505	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I5M56_RS11510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I5M56_RS11530	COG3069	C4-dicarboxylate transmembrane transporter activity
I5M56_RS11535	COG3719	Belongs to the RNase T2 family
I5M56_RS11540	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I5M56_RS11560	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I5M56_RS11565	COG0583	DNA-binding transcription factor activity
I5M56_RS11575	COG1475	DNA binding
I5M56_RS11580	COG0436	Aminotransferase
I5M56_RS11605	COG1129	ABC transporter
I5M56_RS11610	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M56_RS11615	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M56_RS11625	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5M56_RS11640	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I5M56_RS11650	COG0402	S-adenosylhomocysteine deaminase activity
I5M56_RS11660	COG0483	inositol monophosphate 1-phosphatase activity
I5M56_RS11665	COG2271	Major facilitator Superfamily
I5M56_RS11695	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M56_RS11700	COG1129	ABC transporter
I5M56_RS11705	COG0371	Dehydrogenase
I5M56_RS11725	COG2879	small protein
I5M56_RS11730	COG1966	Carbon starvation protein
I5M56_RS11740	COG1028	Short-chain dehydrogenase reductase Sdr
I5M56_RS11745	COG3433	isochorismatase activity
I5M56_RS11745	COG1535	isochorismatase
I5M56_RS11750	COG1021	2,3-dihydroxybenzoate-AMP ligase
I5M56_RS11755	COG1169	isochorismate synthase
I5M56_RS11760	COG4592	Periplasmic binding protein
I5M56_RS11770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M56_RS11775	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M56_RS11780	COG1120	ATPase activity
I5M56_RS11785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I5M56_RS11785	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I5M56_RS11790	COG3251	PFAM MbtH domain protein
I5M56_RS11795	COG2382	esterase
I5M56_RS11800	COG4771	TonB-dependent receptor
I5M56_RS11805	COG2977	Belongs to the P-Pant transferase superfamily
I5M56_RS11810	COG3958	Transketolase
I5M56_RS11815	COG3959	Transketolase, thiamine diphosphate binding domain
I5M56_RS11820	COG2390	Transcriptional regulator
I5M56_RS11825	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I5M56_RS11830	COG1879	ABC-type sugar transport system periplasmic component
I5M56_RS11840	COG1129	ABC transporter
I5M56_RS11845	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M56_RS11855	COG1028	Short-chain dehydrogenase reductase Sdr
I5M56_RS11865	COG0583	DNA-binding transcription factor activity
I5M56_RS11870	COG0668	transmembrane transport
I5M56_RS11880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I5M56_RS11925	COG0747	negative chemotaxis
I5M56_RS11930	COG0601	transmembrane transport
I5M56_RS11935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5M56_RS11940	COG0444	Belongs to the ABC transporter superfamily
I5M56_RS11945	COG4608	Belongs to the ABC transporter superfamily
I5M56_RS11950	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I5M56_RS11955	COG4221	oxidoreductase activity
I5M56_RS11965	COG4215	(ABC) transporter
I5M56_RS11970	COG0765	amino acid transport
I5M56_RS11975	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I5M56_RS11985	COG0436	Aminotransferase
I5M56_RS11990	COG0697	spore germination
I5M56_RS12005	COG4608	Belongs to the ABC transporter superfamily
I5M56_RS12010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5M56_RS12030	COG3698	Phosphodiester glycosidase
I5M56_RS12070	COG2315	Protein conserved in bacteria
I5M56_RS12075	COG0778	Nitroreductase
I5M56_RS12100	COG0477	Major facilitator Superfamily
I5M56_RS12105	COG0668	transmembrane transport
I5M56_RS12110	COG1609	Transcriptional regulator
I5M56_RS12130	COG2211	Major facilitator Superfamily
I5M56_RS12135	COG1113	amino acid transport
I5M56_RS12140	COG1012	belongs to the aldehyde dehydrogenase family
I5M56_RS12145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5M56_RS12155	COG0531	amino acid
I5M56_RS12200	COG0667	Aldo Keto reductase
I5M56_RS12205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M56_RS12210	COG1473	amidohydrolase
I5M56_RS12235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M56_RS12240	COG1120	ATPase activity
I5M56_RS12245	COG1566	PFAM secretion protein HlyD family protein
I5M56_RS12290	COG4211	Belongs to the binding-protein-dependent transport system permease family
I5M56_RS12295	COG1129	ABC transporter
I5M56_RS12310	COG0673	inositol 2-dehydrogenase activity
I5M56_RS12340	COG3104	oligopeptide transport
I5M56_RS12345	COG1982	Orn Lys Arg decarboxylase major
I5M56_RS12350	COG0531	amino acid
I5M56_RS12355	COG3710	Transcriptional regulator
I5M56_RS12365	COG1560	Kdo2-lipid A biosynthetic process
I5M56_RS12415	COG2501	S4 domain
I5M56_RS12425	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I5M56_RS12440	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I5M56_RS12445	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I5M56_RS12450	COG0549	Belongs to the carbamate kinase family
I5M56_RS12460	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I5M56_RS12465	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I5M56_RS12470	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I5M56_RS12475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I5M56_RS12480	COG3257	ureidoglycine aminohydrolase activity
I5M56_RS12485	COG1929	Belongs to the glycerate kinase type-1 family
I5M56_RS12490	COG2233	PERMEase
I5M56_RS12500	COG1953	Uracil, thiamine, allantoin
I5M56_RS12510	COG2084	Dehydrogenase
I5M56_RS12515	COG3622	Belongs to the hyi family
I5M56_RS12520	COG3960	tartronate-semialdehyde synthase activity
I5M56_RS12555	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I5M56_RS12560	COG4181	ATPase activity
I5M56_RS12565	COG2755	lipolytic protein G-D-S-L family
I5M56_RS12570	COG0300	oxidoreductase activity
I5M56_RS12575	COG3118	belongs to the thioredoxin family
I5M56_RS12580	COG0390	transport system, permease component
I5M56_RS12585	COG4619	ABC transporter
I5M56_RS12590	COG0330	HflC and HflK could
I5M56_RS12595	COG1585	Membrane protein implicated in regulation of membrane protease activity
I5M56_RS12610	COG3735	TraB family
I5M56_RS12615	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I5M56_RS12625	COG2223	nitrite transmembrane transporter activity
I5M56_RS12630	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I5M56_RS12630	COG4651	solute:proton antiporter activity
I5M56_RS12635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5M56_RS12675	COG2832	Protein of unknown function (DUF454)
I5M56_RS12680	COG3923	Primosomal replication protein n
I5M56_RS12695	COG1196	nuclear chromosome segregation
I5M56_RS12695	COG3264	Mechanosensitive ion channel
I5M56_RS12700	COG1309	transcriptional regulator
I5M56_RS12705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M56_RS12710	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5M56_RS12725	COG0110	maltose O-acetyltransferase activity
I5M56_RS12775	COG1874	Beta-galactosidase
I5M56_RS12780	COG3867	Arabinogalactan endo-beta-1,4-galactanase
I5M56_RS12785	COG3833	ABC-type maltose transport systems, permease component
I5M56_RS12790	COG1175	transmembrane transport
I5M56_RS12795	COG2182	Extracellular solute-binding protein
I5M56_RS12805	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I5M56_RS12820	COG2364	Membrane
I5M56_RS12850	COG3695	enzyme binding
I5M56_RS12855	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I5M56_RS12860	COG1946	Acyl-CoA thioesterase
I5M56_RS12865	COG0004	ammonium transporteR
I5M56_RS12870	COG0347	Belongs to the P(II) protein family
I5M56_RS12875	COG1132	(ABC) transporter
I5M56_RS12880	COG1132	(ABC) transporter
I5M56_RS12885	COG1522	sequence-specific DNA binding
I5M56_RS12900	COG4533	DNA binding
I5M56_RS12910	COG0824	Thioesterase
I5M56_RS12915	COG1555	photosystem II stabilization
I5M56_RS12920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5M56_RS12925	COG0776	regulation of translation
I5M56_RS12930	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I5M56_RS12950	COG0271	Belongs to the BolA IbaG family
I5M56_RS12955	COG3056	Lipoprotein
I5M56_RS12960	COG2223	nitrite transmembrane transporter activity
I5M56_RS12965	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I5M56_RS12970	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I5M56_RS12975	COG1845	cytochrome c oxidase, subunit III
I5M56_RS12980	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I5M56_RS12995	COG1414	Transcriptional regulator
I5M56_RS13000	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I5M56_RS13005	COG1053	succinate dehydrogenase
I5M56_RS13015	COG1053	succinate dehydrogenase
I5M56_RS13030	COG0673	inositol 2-dehydrogenase activity
I5M56_RS13035	COG2814	Major facilitator Superfamily
I5M56_RS13045	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I5M56_RS13070	COG0142	geranyltranstransferase activity
I5M56_RS13080	COG0667	Aldo Keto reductase
I5M56_RS13085	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I5M56_RS13105	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I5M56_RS13105	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I5M56_RS13115	COG4238	major outer membrane lipoprotein
I5M56_RS13135	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I5M56_RS13140	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I5M56_RS13145	COG1862	Preprotein translocase
I5M56_RS13170	COG0450	alkyl hydroperoxide reductase
I5M56_RS13180	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M56_RS13195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5M56_RS13205	COG1228	amidohydrolase
I5M56_RS13215	COG1335	isochorismatase
I5M56_RS13220	COG0583	DNA-binding transcription factor activity
I5M56_RS13225	COG0366	Alpha amylase catalytic
I5M56_RS13250	COG0420	3'-5' exonuclease activity
I5M56_RS13255	COG0419	ATPase involved in DNA repair
I5M56_RS13260	COG1940	carbohydrate kinase activity
I5M56_RS13275	COG4126	flavin adenine dinucleotide binding
I5M56_RS13285	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I5M56_RS13290	COG3416	Protein conserved in bacteria
I5M56_RS13300	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I5M56_RS13310	COG1785	Belongs to the alkaline phosphatase family
I5M56_RS13350	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I5M56_RS13355	COG1335	isochorismatase
I5M56_RS13360	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I5M56_RS13365	COG0113	porphobilinogen synthase activity
I5M56_RS13370	COG1943	Transposase
I5M56_RS13380	COG2175	clavaminate synthase activity
I5M56_RS13385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5M56_RS13390	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I5M56_RS13395	COG4521	taurine ABC transporter
I5M56_RS13400	COG2040	homocysteine
I5M56_RS13405	COG0833	amino acid
I5M56_RS13420	COG4303	Ethanolamine ammonia lyase large subunit
I5M56_RS13425	COG4302	ethanolamine ammonia-lyase activity
I5M56_RS13465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M56_RS13470	COG1126	abc transporter atp-binding protein
I5M56_RS13475	COG0765	amino acid transport
I5M56_RS13480	COG0765	amino acid transport
I5M56_RS13495	COG3188	usher protein
I5M56_RS13520	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I5M56_RS13530	COG3639	organic phosphonate transmembrane transporter activity
I5M56_RS13545	COG0791	NLP P60 protein
I5M56_RS13615	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I5M56_RS13620	COG0022	dehydrogenase e1 component
I5M56_RS13625	COG0508	dehydrogenase complex catalyzes the overall conversion of
I5M56_RS13630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5M56_RS13640	COG0625	glutathione transferase activity
I5M56_RS13645	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I5M56_RS13660	COG0579	oxidoreductase
I5M56_RS13665	COG1012	belongs to the aldehyde dehydrogenase family
I5M56_RS13670	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I5M56_RS13675	COG1113	amino acid transport
I5M56_RS13680	COG1802	Transcriptional regulator
I5M56_RS13700	COG2195	Cleaves the N-terminal amino acid of tripeptides
I5M56_RS13705	COG0454	-acetyltransferase
I5M56_RS13720	COG2991	Protein conserved in bacteria
I5M56_RS13735	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I5M56_RS13740	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I5M56_RS13755	COG3034	peptidoglycan biosynthetic process
I5M56_RS13760	COG0121	glutamine amidotransferase
I5M56_RS13770	COG1960	acyl-CoA dehydrogenase activity
I5M56_RS13775	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I5M56_RS13790	COG0583	DNA-binding transcription factor activity
I5M56_RS13810	COG2226	methyltransferase
I5M56_RS13820	COG0741	lytic transglycosylase activity
I5M56_RS13820	COG1388	LysM domain
I5M56_RS13825	COG2226	methyltransferase
I5M56_RS13835	COG2814	Major facilitator Superfamily
I5M56_RS13840	COG0583	DNA-binding transcription factor activity
I5M56_RS13845	COG0656	L-ascorbic acid biosynthetic process
I5M56_RS13880	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I5M56_RS13890	COG2011	ABC-type metal ion transport system permease component
I5M56_RS13895	COG1464	Belongs to the NlpA lipoprotein family
I5M56_RS13905	COG1720	tRNA m6t6A37 methyltransferase activity
I5M56_RS13920	COG3015	lipoprotein NlpE involved in copper resistance
I5M56_RS13925	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I5M56_RS13940	COG4568	rho-dependent transcription termination
I5M56_RS13950	COG0346	lactoylglutathione lyase activity
I5M56_RS13955	COG1982	Orn Lys Arg decarboxylase major
I5M56_RS13965	COG0587	DNA-directed DNA polymerase activity
I5M56_RS13995	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I5M56_RS14005	COG0750	zinc metalloprotease
I5M56_RS14010	COG0575	Belongs to the CDS family
I5M56_RS14045	COG0024	Methionine aminopeptidase
I5M56_RS14050	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I5M56_RS14065	COG3835	regulator
I5M56_RS14070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5M56_RS14090	COG2860	membrane
I5M56_RS14110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M56_RS14115	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I5M56_RS14120	COG1120	ATPase activity
I5M56_RS14125	COG4774	siderophore transport
I5M56_RS14130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I5M56_RS14220	COG1643	Atp-dependent helicase
I5M56_RS14225	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I5M56_RS14245	COG0617	tRNA 3'-terminal CCA addition
I5M56_RS14250	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I5M56_RS14270	COG0726	polysaccharide deacetylase
I5M56_RS14275	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M56_RS14280	COG0842	Transport permease protein
I5M56_RS14285	COG1131	(ABC) transporter
I5M56_RS14290	COG0288	reversible hydration of carbon dioxide
I5M56_RS14305	COG4993	Dehydrogenase
I5M56_RS14310	COG2132	Multicopper oxidase
I5M56_RS14350	COG3064	Membrane
I5M56_RS14365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5M56_RS14370	COG0508	dehydrogenase complex catalyzes the overall conversion of
I5M56_RS14375	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I5M56_RS14380	COG2186	Transcriptional regulator
I5M56_RS14385	COG1113	amino acid transport
I5M56_RS14390	COG2211	Major facilitator Superfamily
I5M56_RS14395	COG3940	Belongs to the glycosyl hydrolase 43 family
I5M56_RS14400	COG3725	Membrane protein required for beta-lactamase induction
I5M56_RS14450	COG3423	Transcriptional regulator
I5M56_RS14470	COG4969	Belongs to the N-Me-Phe pilin family
I5M56_RS14475	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I5M56_RS14480	COG1459	type II secretion system
I5M56_RS14505	COG0494	nUDIX hydrolase
I5M56_RS14525	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I5M56_RS14530	COG0849	cell division
I5M56_RS14555	COG0772	Belongs to the SEDS family
I5M56_RS14570	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I5M56_RS14580	COG0768	penicillin binding
I5M56_RS14600	COG1609	Transcriptional regulator
I5M56_RS14610	COG0028	Belongs to the TPP enzyme family
I5M56_RS14650	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I5M56_RS14655	COG0738	Major facilitator superfamily
I5M56_RS14665	COG0583	DNA-binding transcription factor activity
I5M56_RS14670	COG2271	Major facilitator Superfamily
I5M56_RS14675	COG2814	Major facilitator Superfamily
I5M56_RS14695	COG1178	ABC-type Fe3 transport system permease component
I5M56_RS14705	COG0586	Pfam SNARE associated Golgi protein
I5M56_RS14730	COG0417	DNA replication proofreading
I5M56_RS14740	COG0564	pseudouridine synthase activity
I5M56_RS14750	COG3493	citrate carrier protein
I5M56_RS14765	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I5M56_RS14770	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I5M56_RS14780	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I5M56_RS14825	COG0505	Belongs to the CarA family
I5M56_RS14870	COG0511	ligase activity, forming carbon-carbon bonds
I5M56_RS14870	COG5016	pyruvate
I5M56_RS14890	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I5M56_RS14915	COG1047	Peptidyl-prolyl cis-trans
I5M56_RS14930	COG0196	riboflavin kinase activity
I5M56_RS14940	COG0583	DNA-binding transcription factor activity
I5M56_RS14965	COG4735	regulation of single-species biofilm formation
I5M56_RS14970	COG1584	GPR1 FUN34 yaaH family protein
I5M56_RS14975	COG0477	Major facilitator Superfamily
I5M56_RS14980	COG0521	Mo-molybdopterin cofactor biosynthetic process
I5M56_RS14985	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I5M56_RS14990	COG1115	amino acid carrier protein
I5M56_RS15000	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I5M56_RS15010	COG0460	homoserine dehydrogenase
I5M56_RS15010	COG0527	aspartate kinase activity
I5M56_RS15020	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I5M56_RS15030	COG0745	RESPONSE REGULATOR receiver
I5M56_RS15035	COG4452	Inner membrane protein CreD
I5M56_RS15040	COG2205	protein histidine kinase activity
I5M56_RS15045	COG0745	RESPONSE REGULATOR receiver
I5M56_RS15050	COG3045	CreA protein
I5M56_RS15055	COG3708	Transcriptional regulator
I5M56_RS15055	COG2207	Transcriptional regulator
I5M56_RS15075	COG0741	lytic transglycosylase activity
I5M56_RS15080	COG0488	(ABC) transporter
I5M56_RS15090	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I5M56_RS15095	COG0560	Phosphoserine phosphatase
I5M56_RS15100	COG3726	membrane protein affecting hemolysin expression
I5M56_RS15130	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I5M56_RS15135	COG0084	hydrolase, TatD family'
I5M56_RS15140	COG4667	esterase of the alpha-beta hydrolase superfamily
I5M56_RS15150	COG2823	Periplasmic or secreted lipoprotein
I5M56_RS15160	COG1011	Hydrolase
I5M56_RS15165	COG0456	acetyltransferase
I5M56_RS15170	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I5M56_RS15205	COG3706	GGDEF domain
I5M56_RS15210	COG4114	ferric iron reductase
I5M56_RS15215	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M56_RS15215	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M56_RS15220	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I5M56_RS15225	COG2197	response regulator
I5M56_RS15230	COG2197	response regulator
I5M56_RS15235	COG1917	Cupin 2, conserved barrel domain protein
I5M56_RS15235	COG2169	Transcriptional regulator
I5M56_RS15245	COG2966	Psort location CytoplasmicMembrane, score
I5M56_RS15260	COG1484	DNA-dependent DNA replication
I5M56_RS15275	COG5464	transposase or invertase
I5M56_RS15280	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I5M56_RS15285	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I5M56_RS15290	COG3716	PTS system mannose fructose sorbose family IID component
I5M56_RS15295	COG3715	PTS system
I5M56_RS15310	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I5M56_RS15310	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I5M56_RS15315	COG0456	acetyltransferase
I5M56_RS15315	COG1214	PFAM Peptidase M22, glycoprotease
I5M56_RS15330	COG0531	amino acid
I5M56_RS15335	COG1012	belongs to the aldehyde dehydrogenase family
I5M56_RS15340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I5M56_RS15370	COG1846	Transcriptional regulator
I5M56_RS15380	COG0179	Fumarylacetoacetate (FAA) hydrolase
I5M56_RS15390	COG1012	belongs to the aldehyde dehydrogenase family
I5M56_RS15395	COG3384	dioxygenase
I5M56_RS15405	COG3971	2-oxopent-4-enoate hydratase activity
I5M56_RS15425	COG2368	4-hydroxyphenylacetate
I5M56_RS15430	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I5M56_RS15435	COG1966	Carbon starvation protein
I5M56_RS15440	COG2879	small protein
I5M56_RS15445	COG0523	cobalamin synthesis protein
I5M56_RS15460	COG1012	belongs to the aldehyde dehydrogenase family
I5M56_RS15465	COG5464	transposase or invertase
I5M56_RS15470	COG1917	Cupin 2, conserved barrel domain protein
I5M56_RS15470	COG2207	Transcriptional regulator
I5M56_RS15480	COG2733	membrane
I5M56_RS15485	COG2814	Major facilitator Superfamily
I5M56_RS15495	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I5M56_RS15500	COG1924	4 iron, 4 sulfur cluster binding
I5M56_RS15515	COG1566	PFAM secretion protein HlyD family protein
I5M56_RS15525	COG5457	Domain of unknown function (DUF1127)
I5M56_RS15530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5M56_RS15540	COG0583	DNA-binding transcription factor activity
I5M56_RS15580	COG1012	belongs to the aldehyde dehydrogenase family
I5M56_RS15580	COG1454	alcohol dehydrogenase
I5M56_RS15595	COG1882	Formate acetyltransferase
I5M56_RS15600	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I5M56_RS15610	COG4869	propanediol catabolic process
I5M56_RS15635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M56_RS15640	COG1129	ABC transporter
I5M56_RS15640	COG0842	Transport permease protein
I5M56_RS15645	COG0842	Transport permease protein
I5M56_RS15680	COG2850	peptidyl-arginine hydroxylation
I5M56_RS15685	COG5002	protein histidine kinase activity
I5M56_RS15690	COG0745	RESPONSE REGULATOR receiver
I5M56_RS15695	COG1538	Outer membrane efflux protein
I5M56_RS15700	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M56_RS15705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M56_RS15710	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5M56_RS15720	COG3040	lipid binding
I5M56_RS15725	COG0789	Transcriptional regulator
I5M56_RS15740	COG0300	oxidoreductase activity
I5M56_RS15755	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I5M56_RS15775	COG3272	Protein of unknown function (DUF1722)
I5M56_RS15780	COG4580	involved in the transport of maltose and maltodextrins
I5M56_RS15790	COG2211	Major facilitator Superfamily
I5M56_RS15795	COG3507	Belongs to the glycosyl hydrolase 43 family
I5M56_RS15860	COG0556	nucleotide-excision repair
I5M56_RS15865	COG0582	viral genome integration into host DNA
I5M56_RS15875	COG0288	reversible hydration of carbon dioxide
I5M56_RS15880	COG0659	secondary active sulfate transmembrane transporter activity
I5M56_RS15885	COG1064	alcohol dehydrogenase
I5M56_RS15890	COG1175	transmembrane transport
I5M56_RS15895	COG0395	ABC-type sugar transport system, permease component
I5M56_RS15900	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I5M56_RS15905	COG3842	ATPase activity
I5M56_RS15910	COG1653	transport
I5M56_RS15920	COG1082	Xylose isomerase domain protein TIM barrel
I5M56_RS15930	COG3962	Belongs to the TPP enzyme family
I5M56_RS15935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5M56_RS15940	COG0837	glucose binding
I5M56_RS15940	COG1737	Transcriptional regulator
I5M56_RS15945	COG3718	enzyme involved in inositol metabolism
I5M56_RS15960	COG0433	COG0433 Predicted ATPase
I5M56_RS15965	COG0795	lipopolysaccharide-transporting ATPase activity
I5M56_RS15970	COG0795	lipopolysaccharide-transporting ATPase activity
I5M56_RS15980	COG2927	DNA polymerase III (CHI subunit)
I5M56_RS15985	COG0525	valine-tRNA ligase activity
I5M56_RS16010	COG2731	YhcH YjgK YiaL family protein
I5M56_RS16045	COG1263	PTS System
I5M56_RS16045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5M56_RS16050	COG0366	Alpha amylase catalytic
I5M56_RS16060	COG0602	queuosine metabolic process
I5M56_RS16065	COG2026	Addiction module toxin, RelE StbE family
I5M56_RS16070	COG3077	Addiction module antitoxin, RelB DinJ family
I5M56_RS16075	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M56_RS16075	COG3711	transcriptional antiterminator
I5M56_RS16080	COG2706	6-phosphogluconolactonase activity
I5M56_RS16095	COG3964	amidohydrolase
I5M56_RS16130	COG0312	modulator of DNA gyrase
I5M56_RS16150	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I5M56_RS16160	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M56_RS16165	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M56_RS16170	COG1129	ABC transporter
I5M56_RS16175	COG1879	ABC-type sugar transport system periplasmic component
I5M56_RS16190	COG2105	PFAM AIG2 family protein
I5M56_RS16195	COG2911	Protein conserved in bacteria
I5M56_RS16200	COG0729	surface antigen
I5M56_RS16210	COG1253	flavin adenine dinucleotide binding
I5M56_RS16235	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I5M56_RS16250	COG1733	regulation of RNA biosynthetic process
I5M56_RS16255	COG0702	epimerase
I5M56_RS16265	COG0697	spore germination
I5M56_RS16275	COG1113	amino acid transport
I5M56_RS16280	COG0545	Peptidyl-prolyl cis-trans isomerase
I5M56_RS16285	COG3061	Opacity-associated protein A
I5M56_RS16295	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I5M56_RS16300	COG2965	DNA replication, synthesis of RNA primer
I5M56_RS16360	COG1073	alpha beta
I5M56_RS16365	COG3650	response to hydrogen peroxide
I5M56_RS16375	COG1960	acyl-CoA dehydrogenase activity
I5M56_RS16380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I5M56_RS16385	COG0557	exoribonuclease II activity
I5M56_RS16400	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I5M56_RS16410	COG0330	HflC and HflK could
I5M56_RS16415	COG0330	HflC and HflK could
I5M56_RS16420	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I5M56_RS16440	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5M56_RS16445	COG0802	atpase or kinase
I5M56_RS16450	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I5M56_RS16450	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I5M56_RS16455	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I5M56_RS16475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M56_RS16495	COG3264	Mechanosensitive ion channel
I5M56_RS16495	COG1511	domain protein
I5M56_RS16510	COG1053	succinate dehydrogenase
I5M56_RS16515	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I5M56_RS16535	COG2076	Multidrug Resistance protein
I5M56_RS16545	COG5510	response to toxic substance
I5M56_RS16555	COG1509	lysine 2,3-aminomutase activity
I5M56_RS16570	COG3121	Chaperone
I5M56_RS16620	COG0531	amino acid
I5M56_RS16625	COG3030	protein affecting phage T7 exclusion by the F plasmid
I5M56_RS16630	COG1027	Aspartate ammonia-lyase
I5M56_RS16635	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I5M56_RS16650	COG1309	transcriptional regulator
I5M56_RS16675	COG0457	Tetratricopeptide repeat
I5M56_RS16680	COG1649	PFAM Uncharacterised BCR, COG1649
I5M56_RS16680	COG0726	polysaccharide deacetylase
I5M56_RS16685	COG1215	transferase activity, transferring glycosyl groups
I5M56_RS16700	COG0861	Integral membrane protein TerC family
I5M56_RS16730	COG1486	melibiose metabolic process
I5M56_RS16735	COG2169	Transcriptional regulator
I5M56_RS16745	COG2824	Alkylphosphonate utilization operon protein PhnA
I5M56_RS16750	COG2764	glyoxalase bleomycin resistance protein dioxygenase
I5M56_RS16755	COG2188	Transcriptional regulator
I5M56_RS16760	COG3624	Phosphonate C-P lyase system protein PhnG
I5M56_RS16765	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I5M56_RS16770	COG3626	phosphonate metabolism
I5M56_RS16775	COG3627	carbon phosphorus lyase activity
I5M56_RS16780	COG4107	phosphonate C-P lyase system protein PhnK
I5M56_RS16785	COG4778	phosphonate C-P lyase system protein PhnL
I5M56_RS16790	COG3454	Phosphonate metabolism
I5M56_RS16800	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I5M56_RS16810	COG4191	Histidine kinase
I5M56_RS16810	COG0784	Response regulator, receiver
I5M56_RS16815	COG1129	ABC transporter
I5M56_RS16820	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M56_RS16845	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I5M56_RS16850	COG1301	dicarboxylic acid transport
I5M56_RS16865	COG3162	membrane
I5M56_RS16895	COG3539	Fimbrial protein
I5M56_RS16900	COG1346	cytolysis
I5M56_RS16905	COG1380	Effector of murein hydrolase LrgA
I5M56_RS16910	COG0583	DNA-binding transcription factor activity
I5M56_RS16915	COG0025	NhaP-type Na H and K H
I5M56_RS16920	COG2252	PERMEase
I5M56_RS16925	COG0625	glutathione transferase activity
I5M56_RS16930	COG0789	Transcriptional regulator
I5M56_RS16940	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I5M56_RS16965	COG3842	ATPase activity
I5M56_RS16970	COG1234	tRNA 3'-trailer cleavage
I5M56_RS16975	COG1609	Transcriptional regulator
I5M56_RS16980	COG0483	inositol monophosphate 1-phosphatase activity
I5M56_RS16990	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I5M56_RS17005	COG4771	TonB-dependent receptor
I5M56_RS17025	COG2315	Protein conserved in bacteria
I5M56_RS17030	COG0432	Pfam Uncharacterised protein family UPF0047
I5M56_RS17045	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I5M56_RS17050	COG0305	Participates in initiation and elongation during chromosome replication
I5M56_RS17065	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I5M56_RS17075	COG0735	belongs to the Fur family
I5M56_RS17080	COG3237	CsbD-like
I5M56_RS17085	COG0534	Mate efflux family protein
I5M56_RS17095	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I5M56_RS17165	COG0251	oxidation-reduction process
I5M56_RS17175	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I5M56_RS17185	COG0527	aspartate kinase activity
I5M56_RS17245	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I5M56_RS17255	COG0456	acetyltransferase
I5M56_RS17285	COG0151	Belongs to the GarS family
I5M56_RS17295	COG4191	Histidine kinase
I5M56_RS17300	COG3678	ATP-independent chaperone mediated protein folding
I5M56_RS17335	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I5M56_RS17350	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I5M56_RS17355	COG2104	thiamine diphosphate biosynthetic process
I5M56_RS17370	COG3706	GGDEF domain
I5M56_RS17380	COG1447	Phosphotransferase system cellobiose-specific component IIA
I5M56_RS17385	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I5M56_RS17420	COG0250	Participates in transcription elongation, termination and antitermination
I5M56_RS17465	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I5M56_RS17495	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I5M56_RS17505	COG1739	Uncharacterized protein family UPF0029
I5M56_RS17545	COG0805	protein transport
I5M56_RS17565	COG3165	ubiquinone biosynthetic process from chorismate
I5M56_RS17585	COG0412	Dienelactone hydrolase
I5M56_RS17595	COG0583	DNA-binding transcription factor activity
I5M56_RS17600	COG0697	spore germination
I5M56_RS17605	COG0561	phosphatase activity
I5M56_RS17610	COG2267	carboxylic ester hydrolase activity
I5M56_RS17615	COG1280	lysine exporter protein (LysE YggA)
I5M56_RS17625	COG1280	lysine exporter protein (LysE YggA)
I5M56_RS17655	COG0210	DNA helicase
I5M56_RS17660	COG1011	Hydrolase
I5M56_RS17690	COG3072	Adenylate cyclase
I5M56_RS17705	COG2959	enzyme of heme biosynthesis
I5M56_RS17710	COG3071	HemY protein
I5M56_RS17755	COG2244	polysaccharide biosynthetic process
I5M56_RS17760	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I5M56_RS17765	COG0456	acetyltransferase
I5M56_RS17770	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I5M56_RS17775	COG1088	dTDP-glucose 4,6-dehydratase activity
I5M56_RS17780	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I5M56_RS17785	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I5M56_RS17795	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I5M56_RS17800	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I5M56_RS17805	COG3118	belongs to the thioredoxin family
I5M56_RS17825	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5M56_RS17830	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5M56_RS17840	COG0583	DNA-binding transcription factor activity
I5M56_RS17845	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I5M56_RS17860	COG3978	acetolactate synthase activity
I5M56_RS17880	COG3085	chromosome segregation
I5M56_RS17955	COG0583	DNA-binding transcription factor activity
I5M56_RS17970	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I5M56_RS17985	COG3443	Belongs to the bacterial solute-binding protein 9 family
I5M56_RS17990	COG2207	Transcriptional regulator
I5M56_RS18000	COG0371	Dehydrogenase
I5M56_RS18015	COG1263	PTS System
I5M56_RS18015	COG2190	(PTS) system
I5M56_RS18015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5M56_RS18020	COG1609	Transcriptional regulator
I5M56_RS18025	COG0583	DNA-binding transcription factor activity
I5M56_RS18030	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5M56_RS18035	COG0460	homoserine dehydrogenase
I5M56_RS18035	COG0527	aspartate kinase activity
I5M56_RS18040	COG0626	cystathionine gamma-synthase activity
I5M56_RS18055	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I5M56_RS18060	COG1609	Transcriptional regulator
I5M56_RS18065	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I5M56_RS18080	COG1575	Belongs to the MenA family. Type 1 subfamily
I5M56_RS18100	COG3678	ATP-independent chaperone mediated protein folding
I5M56_RS18105	COG0745	RESPONSE REGULATOR receiver
I5M56_RS18110	COG2205	protein histidine kinase activity
I5M56_RS18115	COG2258	MOSC domain
I5M56_RS18120	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I5M56_RS18160	COG1129	ABC transporter
I5M56_RS18165	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M56_RS18175	COG1454	alcohol dehydrogenase
I5M56_RS18185	COG0110	maltose O-acetyltransferase activity
I5M56_RS18190	COG2211	Major facilitator Superfamily
I5M56_RS18250	COG0205	6-phosphofructokinase activity
I5M56_RS18270	COG0437	4 iron, 4 sulfur cluster binding
I5M56_RS18275	COG2864	formate dehydrogenase
I5M56_RS18290	COG0456	acetyltransferase
I5M56_RS18305	COG1011	Hydrolase
I5M56_RS18310	COG2271	Major facilitator Superfamily
I5M56_RS18315	COG1082	Xylose isomerase domain protein TIM barrel
I5M56_RS18320	COG2188	Transcriptional regulator
I5M56_RS18335	COG3852	Histidine kinase
I5M56_RS18365	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I5M56_RS18365	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I5M56_RS18370	COG0204	Acyl-transferase
I5M56_RS18380	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I5M56_RS18385	COG3084	Protein conserved in bacteria
I5M56_RS18395	COG1763	Mo-molybdopterin cofactor biosynthetic process
I5M56_RS18420	COG2186	Transcriptional regulator
I5M56_RS18425	COG0477	Major facilitator Superfamily
I5M56_RS18430	COG1609	Transcriptional regulator
I5M56_RS18435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5M56_RS18445	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5M56_RS18450	COG1129	ABC transporter
I5M56_RS18480	COG1522	sequence-specific DNA binding
I5M56_RS18485	COG0716	FMN binding
I5M56_RS18500	COG3312	ion transport
I5M56_RS18550	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I5M56_RS18555	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I5M56_RS18560	COG0573	inorganic phosphate transmembrane transporter activity
I5M56_RS18565	COG0581	inorganic phosphate transmembrane transporter activity
I5M56_RS18570	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I5M56_RS18575	COG0704	Plays a role in the regulation of phosphate uptake
I5M56_RS18585	COG2382	esterase
I5M56_RS18590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5M56_RS18595	COG2252	PERMEase
I5M56_RS18600	COG0431	NADPH-dependent FMN reductase
I5M56_RS18605	COG2091	lysine biosynthetic process via aminoadipic acid
I5M56_RS18635	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I5M56_RS18665	COG0187	DNA topoisomerase II activity
I5M56_RS18670	COG0561	phosphatase activity
I5M56_RS18685	COG0823	Involved in the tonB-independent uptake of proteins
I5M56_RS18690	COG5645	(Lipo)protein
I5M56_RS18710	COG2188	Transcriptional regulator
I5M56_RS18725	COG2149	membrane
I5M56_RS18745	COG2610	gluconate transmembrane transporter activity
I5M56_RS18750	COG0583	DNA-binding transcription factor activity
I5M56_RS18755	COG2814	Major facilitator Superfamily
I5M56_RS18785	COG0028	Belongs to the TPP enzyme family
I5M56_RS18790	COG0440	acetolactate synthase activity
I5M56_RS18795	COG2197	response regulator
I5M56_RS18845	COG2188	Transcriptional regulator
I5M56_RS18855	COG3842	ATPase activity
I5M56_RS18870	COG4580	involved in the transport of maltose and maltodextrins
I5M56_RS18875	COG1447	Phosphotransferase system cellobiose-specific component IIA
I5M56_RS18880	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M56_RS18880	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M56_RS18895	COG1609	Transcriptional regulator
I5M56_RS18905	COG3384	dioxygenase
I5M56_RS18910	COG0583	DNA-binding transcription factor activity
I5M56_RS18915	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I5M56_RS18920	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I5M56_RS18925	COG2828	Protein conserved in bacteria
I5M56_RS18940	COG0697	spore germination
I5M56_RS18945	COG1263	PTS System
I5M56_RS18945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5M56_RS18955	COG2814	Major facilitator Superfamily
I5M56_RS18965	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5M56_RS18990	COG1309	transcriptional regulator
I5M56_RS19000	COG0583	DNA-binding transcription factor activity
I5M56_RS19025	COG1464	Belongs to the NlpA lipoprotein family
I5M56_RS19040	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I5M56_RS19050	COG1064	alcohol dehydrogenase
I5M56_RS19060	COG0604	alcohol dehydrogenase
I5M56_RS19075	COG2211	Major facilitator Superfamily
I5M56_RS19080	COG1501	Belongs to the glycosyl hydrolase 31 family
I5M56_RS19090	COG1486	melibiose metabolic process
I5M56_RS19095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5M56_RS19095	COG1263	PTS System
I5M56_RS19100	COG2982	Protein involved in outer membrane biogenesis
I5M56_RS19105	COG2233	PERMEase
I5M56_RS19110	COG0786	glutamate:sodium symporter activity
I5M56_RS19130	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I5M56_RS19155	COG3152	Membrane
I5M56_RS19165	COG1494	fructose-1,6-bisphosphatase
I5M56_RS19170	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I5M56_RS19175	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I5M56_RS19180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I5M56_RS19200	COG2860	membrane
I5M56_RS19210	COG2169	Transcriptional regulator
I5M56_RS19210	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I5M56_RS19215	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I5M56_RS19220	COG1561	YicC-like family, N-terminal region
I5M56_RS19245	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I5M56_RS19280	COG1519	Transferase
I5M56_RS19285	COG1216	Glycosyl transferase, family 2
I5M56_RS19290	COG0438	transferase activity, transferring glycosyl groups
I5M56_RS19300	COG0859	PFAM glycosyl transferase family 9
I5M56_RS19325	COG0859	PFAM glycosyl transferase family 9
I5M56_RS19350	COG0463	Glycosyl transferase, family 2
I5M56_RS19355	COG2861	carbohydrate metabolic process
I5M56_RS19360	COG4942	peptidase
I5M56_RS19370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5M56_RS19375	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I5M56_RS19395	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I5M56_RS19405	COG2186	Transcriptional regulator
I5M56_RS19425	COG3722	fumarate hydratase activity
I5M56_RS19445	COG1566	PFAM secretion protein HlyD family protein
I5M56_RS19450	COG0625	glutathione transferase activity
I5M56_RS19460	COG3276	selenocysteine insertion sequence binding
I5M56_RS19470	COG2211	Major facilitator Superfamily
I5M56_RS19480	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I5M56_RS19485	COG3977	Valine--pyruvate aminotransferase
I5M56_RS19490	COG0366	Alpha amylase catalytic
I5M56_RS19495	COG2992	FlgJ-related protein
I5M56_RS19500	COG2207	Transcriptional regulator
I5M56_RS19500	COG1609	Transcriptional regulator
I5M56_RS19505	COG4214	carbohydrate transport
I5M56_RS19515	COG4213	ABC transporter substrate-binding protein
I5M56_RS19530	COG4682	membrane
I5M56_RS19535	COG3274	enterobacterial common antigen metabolic process
I5M56_RS19565	COG1278	Cold shock
I5M56_RS19570	COG2944	sequence-specific DNA binding
I5M56_RS19575	COG2814	Major facilitator Superfamily
I5M56_RS19595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5M56_RS19605	COG1609	Transcriptional regulator
I5M56_RS19610	COG2885	chlorophyll binding
I5M56_RS19615	COG0243	molybdopterin cofactor binding
I5M56_RS19620	COG0456	acetyltransferase
I5M56_RS19625	COG2818	Glycosylase
I5M56_RS19630	COG5571	outer membrane autotransporter
I5M56_RS19635	COG2223	nitrite transmembrane transporter activity
I5M56_RS19655	COG0747	negative chemotaxis
I5M56_RS19660	COG0601	transmembrane transport
I5M56_RS19665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5M56_RS19670	COG0444	Belongs to the ABC transporter superfamily
I5M56_RS19675	COG4608	Belongs to the ABC transporter superfamily
I5M56_RS19690	COG2894	cell division
I5M56_RS19700	COG1215	transferase activity, transferring glycosyl groups
I5M56_RS19705	COG0457	Tetratricopeptide repeat
I5M56_RS19720	COG2194	sulfuric ester hydrolase activity
I5M56_RS19750	COG1215	transferase activity, transferring glycosyl groups
I5M56_RS19755	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I5M56_RS19760	COG0457	Tetratricopeptide repeat
I5M56_RS19760	COG3118	belongs to the thioredoxin family
I5M56_RS19765	COG2199	diguanylate cyclase activity
I5M56_RS19765	COG2200	EAL domain
I5M56_RS19775	COG0612	Peptidase, M16
I5M56_RS19785	COG2982	Protein involved in outer membrane biogenesis
I5M56_RS19790	COG0477	Major facilitator Superfamily
I5M56_RS19795	COG1295	ribonuclease BN
I5M56_RS19800	COG0583	DNA-binding transcription factor activity
I5M56_RS19810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5M56_RS19820	COG1454	alcohol dehydrogenase
I5M56_RS19830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5M56_RS19835	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I5M56_RS19840	COG0671	phosphoesterase, PA-phosphatase related
I5M56_RS19860	COG0589	response to stress
I5M56_RS19870	COG0306	phosphate transporter
I5M56_RS19875	COG2081	HI0933 family
I5M56_RS19880	COG2239	Acts as a magnesium transporter
I5M56_RS19890	COG1124	(ABC) transporter
I5M56_RS19900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5M56_RS19905	COG0601	transmembrane transport
I5M56_RS19910	COG0747	negative chemotaxis
I5M56_RS19920	COG3479	Phenolic acid decarboxylase
I5M56_RS19960	COG0628	permease
I5M56_RS19965	COG2091	lysine biosynthetic process via aminoadipic acid
I5M56_RS19970	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I5M56_RS19975	COG1028	Short-chain dehydrogenase reductase Sdr
I5M56_RS19985	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I5M56_RS20010	COG0463	Glycosyl transferase, family 2
I5M56_RS20020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I5M56_RS20020	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I5M56_RS20030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I5M56_RS20060	COG0477	Major facilitator Superfamily
I5M56_RS20070	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I5M56_RS20085	COG3714	YhhN family
I5M56_RS20095	COG3776	membrane
I5M56_RS20100	COG0742	ribosomal rna small subunit methyltransferase
I5M56_RS20105	COG0552	protein localization to endoplasmic reticulum
I5M56_RS20110	COG2884	Cell division ATP-binding protein ftsE
I5M56_RS20115	COG2177	Part of the ABC transporter FtsEX involved in
I5M56_RS20130	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I5M56_RS20140	COG0683	leucine binding
I5M56_RS20145	COG4907	membrane protein (DUF2207)
I5M56_RS20150	COG1704	LemA family
I5M56_RS20160	COG0683	leucine binding
I5M56_RS20165	COG0559	Belongs to the binding-protein-dependent transport system permease family
I5M56_RS20205	COG0584	glycerophosphoryl diester phosphodiesterase
I5M56_RS20215	COG0405	Gamma-glutamyltransferase
I5M56_RS20220	COG1247	-acetyltransferase
I5M56_RS20230	COG0673	inositol 2-dehydrogenase activity
I5M56_RS20235	COG1741	Belongs to the pirin family
I5M56_RS20240	COG1609	Transcriptional regulator
I5M56_RS20245	COG3265	gluconokinase activity
I5M56_RS20250	COG2610	gluconate transmembrane transporter activity
I5M56_RS20260	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I5M56_RS20285	COG0058	SHG alpha-glucan phosphorylase activity
I5M56_RS20290	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I5M56_RS20305	COG1349	DNA-binding transcription factor activity
I5M56_RS20315	COG0058	SHG alpha-glucan phosphorylase activity
I5M56_RS20320	COG1640	4-alpha-glucanotransferase
I5M56_RS20325	COG2610	gluconate transmembrane transporter activity
I5M56_RS20335	COG1040	competence protein
I5M56_RS20360	COG1918	ferrous iron import across plasma membrane
I5M56_RS20365	COG2183	response to ionizing radiation
I5M56_RS20370	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I5M56_RS20395	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I5M56_RS20400	COG1011	Hydrolase
I5M56_RS20410	COG0494	nUDIX hydrolase
I5M56_RS20415	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I5M56_RS20420	COG4972	Pilus assembly protein
I5M56_RS20440	COG4796	Type ii and iii secretion system protein
I5M56_RS20455	COG3266	domain, Protein
I5M56_RS20460	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I5M56_RS20465	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I5M56_RS20490	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I5M56_RS20495	COG0402	S-adenosylhomocysteine deaminase activity
I5M56_RS20500	COG0738	Major facilitator superfamily
I5M56_RS20525	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I5M56_RS20530	COG1289	transmembrane transporter activity
I5M56_RS20540	COG1765	OsmC-like protein
I5M56_RS20545	COG3954	Phosphoribulokinase
I5M56_RS20555	COG0429	hydrolase of the alpha beta-hydrolase fold
I5M56_RS20560	COG0488	(ABC) transporter
I5M56_RS20575	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I5M56_RS20580	COG1047	Peptidyl-prolyl cis-trans
I5M56_RS20590	COG0545	Peptidyl-prolyl cis-trans isomerase
I5M56_RS20595	COG2964	Protein conserved in bacteria
I5M56_RS20650	COG0051	transcription antitermination factor activity, RNA binding
I5M56_RS20675	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I5M56_RS20690	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I5M56_RS20755	COG0201	protein transport
I5M56_RS20780	COG0202	RNA polymerase activity
I5M56_RS20795	COG0789	Transcriptional regulator
I5M56_RS20800	COG3036	rescue of stalled ribosome
I5M56_RS20830	COG0758	DNA mediated transformation
I5M56_RS20840	COG0551	DNA topoisomerase type I activity
I5M56_RS20860	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I5M56_RS20895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5M56_RS20900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M56_RS20905	COG1309	transcriptional regulator
I5M56_RS20925	COG4145	pantothenate transmembrane transporter activity
I5M56_RS20930	COG3924	membrane
I5M56_RS20935	COG0439	Biotin carboxylase
I5M56_RS20940	COG0511	ligase activity, forming carbon-carbon bonds
I5M56_RS20965	COG2199	diguanylate cyclase activity
I5M56_RS20965	COG2200	EAL domain
I5M56_RS20970	COG1077	Cell shape determining protein MreB Mrl
I5M56_RS20975	COG1792	Involved in formation and maintenance of cell shape
I5M56_RS20980	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I5M56_RS20990	COG1530	ribonuclease E activity
I5M56_RS20995	COG3164	Protein of unknown function
I5M56_RS21000	COG0312	modulator of DNA gyrase
I5M56_RS21005	COG0583	DNA-binding transcription factor activity
I5M56_RS21020	COG1289	transmembrane transporter activity
I5M56_RS21025	COG2732	(Barnase) inhibitor
I5M56_RS21050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5M56_RS21055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5M56_RS21060	COG3105	Protein conserved in bacteria
I5M56_RS21065	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I5M56_RS21085	COG0625	glutathione transferase activity
I5M56_RS21090	COG2969	positive regulation of protein catabolic process
I5M56_RS21120	COG2731	YhcH YjgK YiaL family protein
I5M56_RS21125	COG0493	'glutamate synthase
I5M56_RS21130	COG0070	glutamate synthase
I5M56_RS21130	COG0069	glutamate synthase activity
I5M56_RS21130	COG0067	glutamate synthase
I5M56_RS21135	COG1242	4 iron, 4 sulfur cluster binding
I5M56_RS21140	COG2271	Major facilitator Superfamily
I5M56_RS21145	COG1063	alcohol dehydrogenase
I5M56_RS21150	COG1312	Catalyzes the dehydration of D-mannonate
I5M56_RS21155	COG2198	Histidine kinase
I5M56_RS21155	COG5002	protein histidine kinase activity
I5M56_RS21155	COG0784	Response regulator, receiver
I5M56_RS21160	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I5M56_RS21165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I5M56_RS21170	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M56_RS21180	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M56_RS21185	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I5M56_RS21190	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I5M56_RS21195	COG1137	ATPase activity
I5M56_RS21200	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I5M56_RS21205	COG3117	lipopolysaccharide transmembrane transporter activity
I5M56_RS21210	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I5M56_RS21220	COG0530	calcium, potassium:sodium antiporter activity
I5M56_RS21225	COG1127	ABC transporter
I5M56_RS21230	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I5M56_RS21235	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I5M56_RS21240	COG2854	intermembrane phospholipid transfer
I5M56_RS21245	COG3113	response to antibiotic
I5M56_RS21250	COG5007	Belongs to the BolA IbaG family
I5M56_RS21260	COG3423	Transcriptional regulator
I5M56_RS21265	COG0142	geranyltranstransferase activity
I5M56_RS21280	COG0697	spore germination
I5M56_RS21290	COG2027	D-alanyl-D-alanine carboxypeptidase
I5M56_RS21300	COG1534	Rna-binding protein
I5M56_RS21310	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I5M56_RS21315	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I5M56_RS21325	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I5M56_RS21365	COG0195	Participates in both transcription termination and antitermination
I5M56_RS21410	COG0814	amino acid
I5M56_RS21415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5M56_RS21420	COG0826	peptidase U32
I5M56_RS21425	COG0826	peptidase U32
I5M56_RS21430	COG3154	lipid carrier protein
I5M56_RS21435	COG3153	acetyltransferase
I5M56_RS21450	COG0693	protein deglycase activity
I5M56_RS21455	COG0702	epimerase
I5M56_RS21460	COG0701	Predicted permease
I5M56_RS21465	COG2823	Periplasmic or secreted lipoprotein
I5M56_RS21485	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I5M56_RS21490	COG2721	sulfolactate sulfo-lyase activity
I5M56_RS21500	COG2084	Dehydrogenase
I5M56_RS21530	COG1741	Belongs to the pirin family
I5M56_RS21535	COG0583	DNA-binding transcription factor activity
I5M56_RS21540	COG3152	Membrane
I5M56_RS21545	COG0435	Glutathione S-transferase
I5M56_RS21550	COG2259	Doxx family
I5M56_RS21560	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I5M56_RS21565	COG4575	ribosome binding
I5M56_RS21570	COG1422	Protein of unknown function (DUF1090)
I5M56_RS21580	COG0586	Pfam SNARE associated Golgi protein
I5M56_RS21585	COG2186	Transcriptional regulator
I5M56_RS21590	COG2271	Major facilitator Superfamily
I5M56_RS21600	COG2721	sulfolactate sulfo-lyase activity
I5M56_RS21615	COG0861	Integral membrane protein TerC family
I5M56_RS21620	COG0673	inositol 2-dehydrogenase activity
I5M56_RS21625	COG1451	nucleotide metabolic process
I5M56_RS21645	COG0446	pyridine nucleotide-disulphide oxidoreductase
I5M56_RS21645	COG1902	pentaerythritol trinitrate reductase activity
I5M56_RS21690	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I5M56_RS21690	COG3408	Glycogen debranching enzyme
I5M56_RS21700	COG0531	amino acid
I5M56_RS21705	COG0531	amino acid
I5M56_RS21710	COG2731	YhcH YjgK YiaL family protein
I5M56_RS21715	COG3250	beta-galactosidase activity
I5M56_RS21720	COG1609	Transcriptional regulator
I5M56_RS21725	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I5M56_RS21735	COG1695	Transcriptional regulator
I5M56_RS21740	COG2375	cellular response to nickel ion
I5M56_RS21755	COG1461	Dihydroxyacetone kinase
I5M56_RS21760	COG2376	Dihydroxyacetone kinase
I5M56_RS21785	COG3247	response to pH
I5M56_RS21795	COG2198	Histidine kinase
I5M56_RS21795	COG2205	protein histidine kinase activity
I5M56_RS21795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M56_RS21795	COG0784	Response regulator, receiver
I5M56_RS21800	COG2197	response regulator
I5M56_RS21820	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I5M56_RS21845	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I5M56_RS21850	COG0358	DNA primase activity
I5M56_RS21855	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I5M56_RS21920	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I5M56_RS21935	COG4991	sh3 domain protein
I5M56_RS21940	COG3025	triphosphatase activity
I5M56_RS21965	COG2960	long-chain fatty acid transporting porin activity
I5M56_RS21980	COG3384	dioxygenase
I5M56_RS21985	COG0754	glutathionylspermidine amidase activity
I5M56_RS21995	COG1538	Outer membrane efflux protein
I5M56_RS22000	COG0494	nUDIX hydrolase
I5M56_RS22005	COG3151	Protein conserved in bacteria
I5M56_RS22010	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I5M56_RS22015	COG3150	esterase
I5M56_RS22025	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I5M56_RS22030	COG2249	NAD(P)H dehydrogenase (quinone) activity
I5M56_RS22035	COG0642	Histidine kinase
I5M56_RS22045	COG3111	PFAM Bacterial OB fold (BOF) protein
I5M56_RS22050	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I5M56_RS22060	COG0204	Acyl-transferase
I5M56_RS22065	COG2132	Multicopper oxidase
I5M56_RS22070	COG1032	radical SAM domain protein
I5M56_RS22075	COG0656	L-ascorbic acid biosynthetic process
I5M56_RS22080	COG1979	alcohol dehydrogenase
I5M56_RS22085	COG2207	Transcriptional regulator
I5M56_RS22090	COG0586	Pfam SNARE associated Golgi protein
I5M56_RS22105	COG0848	biopolymer transport protein
I5M56_RS22125	COG0625	glutathione transferase activity
I5M56_RS22140	COG0754	glutathionylspermidine amidase activity
I5M56_RS22145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5M56_RS22165	COG0583	DNA-binding transcription factor activity
I5M56_RS22170	COG0626	cystathionine gamma-synthase activity
I5M56_RS22185	COG1811	Na channel or pump
I5M56_RS22190	COG1982	Orn Lys Arg decarboxylase major
I5M56_RS22195	COG2211	Major facilitator Superfamily
I5M56_RS22210	COG1194	a g-specific adenine glycosylase
I5M56_RS22220	COG3171	Protein conserved in bacteria
I5M56_RS22235	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I5M56_RS22240	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I5M56_RS22245	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I5M56_RS22260	COG0762	integral membrane protein
I5M56_RS22265	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I5M56_RS22270	COG2805	Type II/IV secretion system protein
I5M56_RS22290	COG0189	ligase activity
I5M56_RS22295	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I5M56_RS22300	COG2356	endonuclease I
I5M56_RS22310	COG2814	Major facilitator Superfamily
I5M56_RS22345	COG2146	nitrite reductase [NAD(P)H] activity
I5M56_RS22360	COG1028	Short-chain dehydrogenase reductase Sdr
I5M56_RS22365	COG1414	Transcriptional regulator
I5M56_RS22395	COG1028	Short-chain dehydrogenase reductase Sdr
I5M56_RS22400	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
I5M56_RS22420	COG0501	Belongs to the peptidase M48B family
I5M56_RS22425	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I5M56_RS22440	COG0191	fructose-bisphosphate aldolase activity
I5M56_RS22445	COG0668	transmembrane transport
I5M56_RS22455	COG2968	Membrane
I5M56_RS22470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5M56_RS22475	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I5M56_RS22495	COG0006	proline dipeptidase activity
I5M56_RS22500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5M56_RS22505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5M56_RS22525	COG1028	Short-chain dehydrogenase reductase Sdr
I5M56_RS22530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5M56_RS22550	COG2723	6-phospho-beta-galactosidase activity
I5M56_RS22555	COG1737	Transcriptional regulator
I5M56_RS22565	COG1272	protein, Hemolysin III
I5M56_RS22575	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I5M56_RS22585	COG0716	FMN binding
I5M56_RS22590	COG4974	Belongs to the 'phage' integrase family
I5M56_RS22600	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I5M56_RS22620	COG4942	peptidase
I5M56_RS22630	COG2814	Major facilitator Superfamily
I5M56_RS22645	COG0667	Aldo Keto reductase
I5M56_RS22650	COG2249	NAD(P)H dehydrogenase (quinone) activity
I5M56_RS22685	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I5M56_RS22690	COG1393	Belongs to the ArsC family
I5M56_RS22705	COG1538	Outer membrane efflux protein
I5M56_RS22710	COG1289	transmembrane transporter activity
I5M56_RS22725	COG3592	Divergent 4Fe-4S mono-cluster
I5M56_RS22730	COG2388	GCN5-related N-acetyl-transferase
I5M56_RS22740	COG3539	Fimbrial protein
I5M56_RS22745	COG3539	Fimbrial protein
I5M56_RS22750	COG3539	Fimbrial protein
I5M56_RS22755	COG3188	usher protein
I5M56_RS22760	COG3121	Chaperone
I5M56_RS22765	COG3539	Fimbrial protein
I5M56_RS22775	COG4974	Belongs to the 'phage' integrase family
I5M56_RS22780	COG0582	viral genome integration into host DNA
I5M56_RS22795	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I5M56_RS22800	COG1846	Transcriptional regulator
I5M56_RS22805	COG0697	spore germination
I5M56_RS22855	COG0667	Aldo Keto reductase
I5M56_RS22860	COG0814	amino acid
I5M56_RS22875	COG0183	Belongs to the thiolase family
I5M56_RS22885	COG0823	Involved in the tonB-independent uptake of proteins
I5M56_RS22890	COG1028	Short-chain dehydrogenase reductase Sdr
I5M56_RS22895	COG2814	Major facilitator Superfamily
I5M56_RS22930	COG3842	ATPase activity
I5M56_RS22935	COG0395	ABC-type sugar transport system, permease component
I5M56_RS22940	COG1175	transmembrane transport
I5M56_RS22945	COG1917	Cupin 2, conserved barrel domain protein
I5M56_RS22950	COG1794	racemase activity, acting on amino acids and derivatives
I5M56_RS22955	COG0583	DNA-binding transcription factor activity
I5M56_RS22965	COG1609	Transcriptional regulator
I5M56_RS22970	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M56_RS22975	COG2723	6-phospho-beta-galactosidase activity
I5M56_RS22980	COG2186	Transcriptional regulator
I5M56_RS22990	COG1609	Transcriptional regulator
I5M56_RS23010	COG0667	Aldo Keto reductase
I5M56_RS23020	COG0861	Integral membrane protein TerC family
I5M56_RS23050	COG2165	general secretion pathway protein
I5M56_RS23055	COG4795	General secretion pathway protein
I5M56_RS23065	COG4967	type IV pilus modification protein PilV
I5M56_RS23070	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I5M56_RS23075	COG1025	Belongs to the peptidase M16 family
I5M56_RS23080	COG1074	ATP-dependent DNA helicase activity
I5M56_RS23085	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I5M56_RS23095	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I5M56_RS23095	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I5M56_RS23100	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5M56_RS23105	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I5M56_RS23135	COG4656	Part of a membrane complex involved in electron transport
I5M56_RS23140	COG1012	belongs to the aldehyde dehydrogenase family
I5M56_RS23140	COG1454	alcohol dehydrogenase
I5M56_RS23155	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
I5M56_RS23170	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I5M56_RS23335	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I5M56_RS23340	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I5M56_RS23345	COG2166	iron-sulfur cluster assembly
I5M56_RS23350	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I5M56_RS23360	COG0583	DNA-binding transcription factor activity
I5M56_RS23365	COG2363	Small membrane protein
I5M56_RS23375	COG1349	DNA-binding transcription factor activity
I5M56_RS23395	COG0738	Major facilitator superfamily
I5M56_RS23400	COG0235	Class ii aldolase
I5M56_RS23405	COG1454	alcohol dehydrogenase
I5M56_RS23420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5M56_RS23435	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I5M56_RS23440	COG2011	ABC-type metal ion transport system permease component
I5M56_RS23445	COG1464	Belongs to the NlpA lipoprotein family
I5M56_RS23450	COG0477	Major facilitator Superfamily
I5M56_RS23460	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5M56_RS23465	COG1760	l-serine dehydratase
I5M56_RS23470	COG0814	amino acid
I5M56_RS23475	COG1611	Belongs to the LOG family
I5M56_RS23490	COG3098	single-species biofilm formation
I5M56_RS23495	COG0564	pseudouridine synthase activity
I5M56_RS23500	COG0716	FMN binding
I5M56_RS23505	COG2271	Major facilitator Superfamily
I5M56_RS23510	COG4948	Mandelate Racemase Muconate Lactonizing
I5M56_RS23515	COG4948	Mandelate Racemase Muconate Lactonizing
I5M56_RS23520	COG1929	Belongs to the glycerate kinase type-1 family
I5M56_RS23525	COG3437	response regulator, receiver
I5M56_RS23525	COG2205	protein histidine kinase activity
I5M56_RS23525	COG4999	Histidine kinase
I5M56_RS23525	COG3850	Histidine kinase
I5M56_RS23535	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I5M56_RS23540	COG3956	TIGRFAM MazG family protein
I5M56_RS23560	COG0602	queuosine metabolic process
I5M56_RS23565	COG0720	synthase
I5M56_RS23585	COG2234	aminopeptidase activity
I5M56_RS23645	COG1388	LysM domain
I5M56_RS23645	COG4942	peptidase
I5M56_RS23650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I5M56_RS23675	COG0163	prenyltransferase activity
I5M56_RS23680	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I5M56_RS23705	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5M56_RS23710	COG4558	Periplasmic binding protein
I5M56_RS23715	COG3720	iron ion transport
I5M56_RS23735	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5M56_RS23740	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5M56_RS23745	COG1121	(ABC) transporter
I5M56_RS23755	COG1609	Transcriptional regulator
I5M56_RS23760	COG1940	carbohydrate kinase activity
I5M56_RS23765	COG1447	Phosphotransferase system cellobiose-specific component IIA
I5M56_RS23770	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M56_RS23775	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M56_RS23780	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5M56_RS23785	COG4580	involved in the transport of maltose and maltodextrins
I5M56_RS23795	COG2723	6-phospho-beta-galactosidase activity
I5M56_RS23805	COG0309	Hydrogenase expression formation protein (HypE)
I5M56_RS23810	COG0409	Hydrogenase expression formation protein
I5M56_RS23815	COG0298	carbon dioxide binding
I5M56_RS23820	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I5M56_RS23835	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I5M56_RS23840	COG0651	ATP synthesis coupled electron transport
I5M56_RS23845	COG0650	Formate hydrogenlyase subunit 4
I5M56_RS23850	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I5M56_RS23850	COG3261	NADH dehydrogenase
I5M56_RS23855	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I5M56_RS23860	COG3260	NADH ubiquinone oxidoreductase 20
I5M56_RS23870	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I5M56_RS23880	COG2723	6-phospho-beta-galactosidase activity
I5M56_RS23885	COG1263	PTS System
I5M56_RS23885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5M56_RS23890	COG1609	Transcriptional regulator
I5M56_RS23895	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I5M56_RS23900	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I5M56_RS23905	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
I5M56_RS23915	COG2814	Major facilitator Superfamily
I5M56_RS23925	COG1414	Transcriptional regulator
I5M56_RS23930	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I5M56_RS23935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5M56_RS23960	COG1349	DNA-binding transcription factor activity
I5M56_RS23965	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5M56_RS23970	COG1028	Short-chain dehydrogenase reductase Sdr
I5M56_RS23980	COG3732	PTS system glucitol sorbitol-specific
I5M56_RS23985	COG3730	PTS system glucitol sorbitol-specific
I5M56_RS23990	COG2951	lytic endotransglycosylase activity
I5M56_RS23995	COG1121	(ABC) transporter
I5M56_RS24000	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5M56_RS24005	COG0803	Belongs to the bacterial solute-binding protein 9 family
I5M56_RS24010	COG1546	Belongs to the CinA family
I5M56_RS24030	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I5M56_RS24060	COG2823	Periplasmic or secreted lipoprotein
I5M56_RS24065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5M56_RS24070	COG1238	metal cluster binding
I5M56_RS24090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I5M56_RS24095	COG2814	Major facilitator Superfamily
I5M56_RS24100	COG1566	PFAM secretion protein HlyD family protein
I5M56_RS24105	COG1846	Transcriptional regulator
I5M56_RS24115	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I5M56_RS24125	COG4176	ABC-type proline glycine betaine transport system permease component
I5M56_RS24140	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I5M56_RS24150	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I5M56_RS24155	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5M56_RS24165	COG4575	ribosome binding
I5M56_RS24195	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5M56_RS24200	COG0640	Transcriptional regulator
I5M56_RS24210	COG0583	DNA-binding transcription factor activity
I5M56_RS24215	COG0671	phosphoesterase, PA-phosphatase related
I5M56_RS24220	COG3284	Transcriptional regulator
I5M56_RS24230	COG3539	Fimbrial protein
I5M56_RS24235	COG3121	Chaperone
I5M56_RS24250	COG3121	Chaperone
I5M56_RS24270	COG1028	Short-chain dehydrogenase reductase Sdr
I5M56_RS24280	COG0235	Class ii aldolase
I5M56_RS24285	COG1126	abc transporter atp-binding protein
I5M56_RS24290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5M56_RS24315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5M56_RS24345	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
I5M56_RS24365	COG0431	NADPH-dependent FMN reductase
I5M56_RS24380	COG2271	Major facilitator Superfamily
I5M56_RS24385	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I5M56_RS24390	COG0477	Major facilitator Superfamily
I5M56_RS24395	COG3622	Belongs to the hyi family
I5M56_RS24420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5M56_RS24430	COG2207	Transcriptional regulator
I5M56_RS24430	COG3708	Transcriptional regulator
I5M56_RS24455	COG1028	Short-chain dehydrogenase reductase Sdr
I5M56_RS24460	COG2814	Major facilitator Superfamily
I5M56_RS24465	COG0028	Belongs to the TPP enzyme family
I5M56_RS24475	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I5M56_RS24495	COG2814	Major facilitator Superfamily
I5M56_RS24525	COG2867	negative regulation of translational initiation
I5M56_RS24540	COG0497	DNA recombination
I5M56_RS24555	COG4536	flavin adenine dinucleotide binding
I5M56_RS24560	COG4137	Cytochrome C assembly protein
I5M56_RS24565	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I5M56_RS24600	COG2885	chlorophyll binding
I5M56_RS24605	COG2199	diguanylate cyclase activity
I5M56_RS24615	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I5M56_RS24620	COG0287	Prephenate dehydrogenase
I5M56_RS24620	COG1605	Chorismate mutase
I5M56_RS24630	COG1605	Chorismate mutase
I5M56_RS24630	COG0077	Prephenate dehydratase
I5M56_RS24640	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I5M56_RS24645	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I5M56_RS24660	COG0542	response to heat
I5M56_RS24940	COG2805	Type II/IV secretion system protein
I5M56_RS24990	COG0741	lytic transglycosylase activity
I5M56_RS25005	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I5M56_RS25155	COG3173	Aminoglycoside phosphotransferase
I5M56_RS25215	COG1660	Displays ATPase and GTPase activities
I5M56_RS25270	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I5M56_RS25275	COG1842	Phage shock protein A
I5M56_RS25285	COG1983	PspC domain protein
I5M56_RS25370	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
I5M56_RS25570	COG5499	transcription regulator containing HTH domain
I5M56_RS25635	COG0431	NADPH-dependent FMN reductase
I5M56_RS25665	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I5M56_RS25695	COG1484	DNA-dependent DNA replication
I5M56_RS25700	COG2963	transposase activity
I5M56_RS25725	COG1475	DNA binding
I5M56_RS25920	COG0697	spore germination
I5M56_RS26100	COG4221	oxidoreductase activity
I5M56_RS26130	COG1121	(ABC) transporter
I5M56_RS26185	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities