locus-tag	class	description
IT777_RS00020	COG0187	DNA topoisomerase II activity
IT777_RS00025	COG0561	phosphatase activity
IT777_RS00040	COG0823	Involved in the tonB-independent uptake of proteins
IT777_RS00045	COG5645	(Lipo)protein
IT777_RS00065	COG2188	Transcriptional regulator
IT777_RS00080	COG2149	membrane
IT777_RS00100	COG2610	gluconate transmembrane transporter activity
IT777_RS00105	COG0583	DNA-binding transcription factor activity
IT777_RS00110	COG2814	Major facilitator Superfamily
IT777_RS00140	COG0028	Belongs to the TPP enzyme family
IT777_RS00145	COG0440	acetolactate synthase activity
IT777_RS00150	COG2197	response regulator
IT777_RS00160	COG2271	Major facilitator Superfamily
IT777_RS00200	COG2188	Transcriptional regulator
IT777_RS00225	COG4580	involved in the transport of maltose and maltodextrins
IT777_RS00230	COG1447	Phosphotransferase system cellobiose-specific component IIA
IT777_RS00235	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IT777_RS00235	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IT777_RS00245	COG1609	Transcriptional regulator
IT777_RS00255	COG3384	dioxygenase
IT777_RS00260	COG0583	DNA-binding transcription factor activity
IT777_RS00265	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IT777_RS00270	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IT777_RS00275	COG2828	Protein conserved in bacteria
IT777_RS00290	COG0697	spore germination
IT777_RS00295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IT777_RS00295	COG1263	PTS System
IT777_RS00305	COG2814	Major facilitator Superfamily
IT777_RS00315	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IT777_RS00320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IT777_RS00340	COG1309	transcriptional regulator
IT777_RS00350	COG0583	DNA-binding transcription factor activity
IT777_RS00375	COG1464	Belongs to the NlpA lipoprotein family
IT777_RS00390	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IT777_RS00400	COG1064	alcohol dehydrogenase
IT777_RS00440	COG1486	melibiose metabolic process
IT777_RS00445	COG1263	PTS System
IT777_RS00445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IT777_RS00450	COG2982	Protein involved in outer membrane biogenesis
IT777_RS00455	COG2233	PERMEase
IT777_RS00460	COG0786	glutamate:sodium symporter activity
IT777_RS00475	COG3074	FtsZ-dependent cytokinesis
IT777_RS00480	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IT777_RS00505	COG3152	Membrane
IT777_RS00515	COG1494	fructose-1,6-bisphosphatase
IT777_RS00520	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IT777_RS00525	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IT777_RS00530	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IT777_RS00550	COG2860	membrane
IT777_RS00575	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IT777_RS00595	COG1561	YicC-like family, N-terminal region
IT777_RS00620	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IT777_RS00655	COG1519	Transferase
IT777_RS00660	COG1216	Glycosyl transferase, family 2
IT777_RS00665	COG0438	transferase activity, transferring glycosyl groups
IT777_RS00675	COG0859	PFAM glycosyl transferase family 9
IT777_RS00700	COG0859	PFAM glycosyl transferase family 9
IT777_RS00725	COG0463	Glycosyl transferase, family 2
IT777_RS00730	COG2861	carbohydrate metabolic process
IT777_RS00735	COG4942	peptidase
IT777_RS00745	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IT777_RS00750	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IT777_RS00770	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IT777_RS00780	COG2186	Transcriptional regulator
IT777_RS00800	COG3722	fumarate hydratase activity
IT777_RS00820	COG1566	PFAM secretion protein HlyD family protein
IT777_RS00825	COG0625	glutathione transferase activity
IT777_RS00835	COG3276	selenocysteine insertion sequence binding
IT777_RS00845	COG2211	Major facilitator Superfamily
IT777_RS00855	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IT777_RS00860	COG3977	Valine--pyruvate aminotransferase
IT777_RS00865	COG0366	Alpha amylase catalytic
IT777_RS00870	COG2992	FlgJ-related protein
IT777_RS00875	COG2207	Transcriptional regulator
IT777_RS00875	COG1609	Transcriptional regulator
IT777_RS00880	COG4214	carbohydrate transport
IT777_RS00890	COG4213	ABC transporter substrate-binding protein
IT777_RS00905	COG4682	membrane
IT777_RS00910	COG4682	membrane
IT777_RS00915	COG3274	enterobacterial common antigen metabolic process
IT777_RS00940	COG0488	(ABC) transporter
IT777_RS00945	COG1278	Cold shock
IT777_RS00950	COG2944	sequence-specific DNA binding
IT777_RS00955	COG2814	Major facilitator Superfamily
IT777_RS00980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IT777_RS00990	COG1609	Transcriptional regulator
IT777_RS00995	COG2885	chlorophyll binding
IT777_RS01000	COG0243	molybdopterin cofactor binding
IT777_RS01005	COG0456	acetyltransferase
IT777_RS01010	COG2818	Glycosylase
IT777_RS01015	COG5571	outer membrane autotransporter
IT777_RS01020	COG2223	nitrite transmembrane transporter activity
IT777_RS01040	COG0747	negative chemotaxis
IT777_RS01045	COG0601	transmembrane transport
IT777_RS01050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IT777_RS01055	COG0444	Belongs to the ABC transporter superfamily
IT777_RS01060	COG4608	Belongs to the ABC transporter superfamily
IT777_RS01075	COG2894	cell division
IT777_RS01085	COG1215	transferase activity, transferring glycosyl groups
IT777_RS01090	COG0457	Tetratricopeptide repeat
IT777_RS01105	COG2194	sulfuric ester hydrolase activity
IT777_RS01135	COG1215	transferase activity, transferring glycosyl groups
IT777_RS01140	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
IT777_RS01145	COG3118	belongs to the thioredoxin family
IT777_RS01145	COG0457	Tetratricopeptide repeat
IT777_RS01150	COG2200	EAL domain
IT777_RS01150	COG2199	diguanylate cyclase activity
IT777_RS01160	COG0612	Peptidase, M16
IT777_RS01170	COG2982	Protein involved in outer membrane biogenesis
IT777_RS01175	COG0477	Major facilitator Superfamily
IT777_RS01180	COG1295	ribonuclease BN
IT777_RS01185	COG0583	DNA-binding transcription factor activity
IT777_RS01190	COG1028	Short-chain dehydrogenase reductase Sdr
IT777_RS01195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IT777_RS01205	COG1454	alcohol dehydrogenase
IT777_RS01215	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IT777_RS01220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IT777_RS01225	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IT777_RS01230	COG0671	phosphoesterase, PA-phosphatase related
IT777_RS01250	COG0589	response to stress
IT777_RS01260	COG0306	phosphate transporter
IT777_RS01265	COG2081	HI0933 family
IT777_RS01270	COG2239	Acts as a magnesium transporter
IT777_RS01280	COG1124	(ABC) transporter
IT777_RS01290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IT777_RS01295	COG0601	transmembrane transport
IT777_RS01300	COG0747	negative chemotaxis
IT777_RS01310	COG3479	Phenolic acid decarboxylase
IT777_RS01350	COG0628	permease
IT777_RS01355	COG2091	lysine biosynthetic process via aminoadipic acid
IT777_RS01360	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IT777_RS01365	COG1028	Short-chain dehydrogenase reductase Sdr
IT777_RS01375	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IT777_RS01400	COG0463	Glycosyl transferase, family 2
IT777_RS01410	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IT777_RS01410	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
IT777_RS01420	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IT777_RS01450	COG0477	Major facilitator Superfamily
IT777_RS01460	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IT777_RS01475	COG3714	YhhN family
IT777_RS01485	COG3776	membrane
IT777_RS01490	COG0742	ribosomal rna small subunit methyltransferase
IT777_RS01495	COG0552	protein localization to endoplasmic reticulum
IT777_RS01500	COG2884	Cell division ATP-binding protein ftsE
IT777_RS01505	COG2177	Part of the ABC transporter FtsEX involved in
IT777_RS01520	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IT777_RS01530	COG0683	leucine binding
IT777_RS01540	COG0683	leucine binding
IT777_RS01545	COG0559	Belongs to the binding-protein-dependent transport system permease family
IT777_RS01585	COG0584	glycerophosphoryl diester phosphodiesterase
IT777_RS01595	COG0405	Gamma-glutamyltransferase
IT777_RS01600	COG1247	-acetyltransferase
IT777_RS01610	COG0673	inositol 2-dehydrogenase activity
IT777_RS01615	COG1741	Belongs to the pirin family
IT777_RS01620	COG1609	Transcriptional regulator
IT777_RS01625	COG3265	gluconokinase activity
IT777_RS01630	COG2610	gluconate transmembrane transporter activity
IT777_RS01640	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IT777_RS01665	COG0058	SHG alpha-glucan phosphorylase activity
IT777_RS01670	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IT777_RS01685	COG1349	DNA-binding transcription factor activity
IT777_RS01695	COG0058	SHG alpha-glucan phosphorylase activity
IT777_RS01700	COG1640	4-alpha-glucanotransferase
IT777_RS01705	COG2610	gluconate transmembrane transporter activity
IT777_RS01715	COG1040	competence protein
IT777_RS01740	COG1918	ferrous iron import across plasma membrane
IT777_RS01745	COG2183	response to ionizing radiation
IT777_RS01750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IT777_RS01775	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IT777_RS01780	COG1011	Hydrolase
IT777_RS01790	COG0494	nUDIX hydrolase
IT777_RS01795	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IT777_RS01820	COG4796	Type ii and iii secretion system protein
IT777_RS01835	COG3266	domain, Protein
IT777_RS01840	COG0338	D12 class N6 adenine-specific DNA methyltransferase
IT777_RS01845	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IT777_RS01870	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IT777_RS01875	COG0402	S-adenosylhomocysteine deaminase activity
IT777_RS01880	COG0738	Major facilitator superfamily
IT777_RS01905	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IT777_RS01910	COG1289	transmembrane transporter activity
IT777_RS01920	COG1765	OsmC-like protein
IT777_RS01925	COG3954	Phosphoribulokinase
IT777_RS01935	COG0429	hydrolase of the alpha beta-hydrolase fold
IT777_RS01940	COG0488	(ABC) transporter
IT777_RS01955	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
IT777_RS01960	COG1047	Peptidyl-prolyl cis-trans
IT777_RS01970	COG0545	Peptidyl-prolyl cis-trans isomerase
IT777_RS01975	COG2964	Protein conserved in bacteria
IT777_RS02030	COG0051	transcription antitermination factor activity, RNA binding
IT777_RS02055	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IT777_RS02070	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IT777_RS02135	COG0201	protein transport
IT777_RS02160	COG0202	RNA polymerase activity
IT777_RS02175	COG0789	Transcriptional regulator
IT777_RS02180	COG3036	rescue of stalled ribosome
IT777_RS02210	COG0758	DNA mediated transformation
IT777_RS02220	COG0551	DNA topoisomerase type I activity
IT777_RS02240	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IT777_RS02275	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IT777_RS02280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IT777_RS02285	COG1309	transcriptional regulator
IT777_RS02305	COG4145	pantothenate transmembrane transporter activity
IT777_RS02310	COG3924	membrane
IT777_RS02315	COG0439	Biotin carboxylase
IT777_RS02320	COG0511	ligase activity, forming carbon-carbon bonds
IT777_RS02345	COG2199	diguanylate cyclase activity
IT777_RS02345	COG2200	EAL domain
IT777_RS02350	COG1077	Cell shape determining protein MreB Mrl
IT777_RS02355	COG1792	Involved in formation and maintenance of cell shape
IT777_RS02360	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IT777_RS02370	COG1530	ribonuclease E activity
IT777_RS02375	COG3164	Protein of unknown function
IT777_RS02380	COG0312	modulator of DNA gyrase
IT777_RS02385	COG0583	DNA-binding transcription factor activity
IT777_RS02400	COG1289	transmembrane transporter activity
IT777_RS02405	COG2732	(Barnase) inhibitor
IT777_RS02430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IT777_RS02435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IT777_RS02440	COG3105	Protein conserved in bacteria
IT777_RS02445	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IT777_RS02465	COG0625	glutathione transferase activity
IT777_RS02470	COG2969	positive regulation of protein catabolic process
IT777_RS02480	COG0493	'glutamate synthase
IT777_RS02485	COG0070	glutamate synthase
IT777_RS02485	COG0069	glutamate synthase activity
IT777_RS02485	COG0067	glutamate synthase
IT777_RS02490	COG1242	4 iron, 4 sulfur cluster binding
IT777_RS02495	COG2271	Major facilitator Superfamily
IT777_RS02500	COG1063	alcohol dehydrogenase
IT777_RS02505	COG1312	Catalyzes the dehydration of D-mannonate
IT777_RS02510	COG5002	protein histidine kinase activity
IT777_RS02510	COG2198	Histidine kinase
IT777_RS02510	COG0784	Response regulator, receiver
IT777_RS02515	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
IT777_RS02520	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IT777_RS02525	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IT777_RS02535	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IT777_RS02540	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IT777_RS02545	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IT777_RS02550	COG1137	ATPase activity
IT777_RS02555	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IT777_RS02560	COG3117	lipopolysaccharide transmembrane transporter activity
IT777_RS02565	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IT777_RS02575	COG0530	calcium, potassium:sodium antiporter activity
IT777_RS02580	COG1127	ABC transporter
IT777_RS02585	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IT777_RS02590	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IT777_RS02595	COG2854	intermembrane phospholipid transfer
IT777_RS02600	COG3113	response to antibiotic
IT777_RS02605	COG5007	Belongs to the BolA IbaG family
IT777_RS02615	COG3423	Transcriptional regulator
IT777_RS02620	COG0142	geranyltranstransferase activity
IT777_RS02635	COG0697	spore germination
IT777_RS02645	COG2027	D-alanyl-D-alanine carboxypeptidase
IT777_RS02655	COG1534	Rna-binding protein
IT777_RS02665	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IT777_RS02670	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IT777_RS02680	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IT777_RS02720	COG0195	Participates in both transcription termination and antitermination
IT777_RS02765	COG0814	amino acid
IT777_RS02770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IT777_RS02775	COG0826	peptidase U32
IT777_RS02780	COG0826	peptidase U32
IT777_RS02785	COG3154	lipid carrier protein
IT777_RS02790	COG3153	acetyltransferase
IT777_RS02805	COG0693	protein deglycase activity
IT777_RS02810	COG0702	epimerase
IT777_RS02815	COG0701	Predicted permease
IT777_RS02820	COG2823	Periplasmic or secreted lipoprotein
IT777_RS02840	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IT777_RS02845	COG2721	sulfolactate sulfo-lyase activity
IT777_RS02855	COG2084	Dehydrogenase
IT777_RS02865	COG0668	transmembrane transport
IT777_RS02880	COG1741	Belongs to the pirin family
IT777_RS02885	COG0583	DNA-binding transcription factor activity
IT777_RS02890	COG3152	Membrane
IT777_RS02895	COG0435	Glutathione S-transferase
IT777_RS02900	COG2259	Doxx family
IT777_RS02910	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
IT777_RS02915	COG4575	ribosome binding
IT777_RS02920	COG1422	Protein of unknown function (DUF1090)
IT777_RS02930	COG0586	Pfam SNARE associated Golgi protein
IT777_RS02935	COG2186	Transcriptional regulator
IT777_RS02940	COG2271	Major facilitator Superfamily
IT777_RS02950	COG2721	sulfolactate sulfo-lyase activity
IT777_RS02965	COG0861	Integral membrane protein TerC family
IT777_RS02970	COG0673	inositol 2-dehydrogenase activity
IT777_RS02975	COG1451	nucleotide metabolic process
IT777_RS02995	COG0446	pyridine nucleotide-disulphide oxidoreductase
IT777_RS02995	COG1902	pentaerythritol trinitrate reductase activity
IT777_RS03045	COG1695	Transcriptional regulator
IT777_RS03050	COG2375	cellular response to nickel ion
IT777_RS03065	COG1461	Dihydroxyacetone kinase
IT777_RS03070	COG2376	Dihydroxyacetone kinase
IT777_RS03135	COG3247	response to pH
IT777_RS03145	COG0784	Response regulator, receiver
IT777_RS03145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IT777_RS03145	COG2205	protein histidine kinase activity
IT777_RS03145	COG2198	Histidine kinase
IT777_RS03150	COG2197	response regulator
IT777_RS03190	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IT777_RS03195	COG0358	DNA primase activity
IT777_RS03200	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IT777_RS03260	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IT777_RS03275	COG4991	sh3 domain protein
IT777_RS03280	COG3025	triphosphatase activity
IT777_RS03305	COG2960	long-chain fatty acid transporting porin activity
IT777_RS03320	COG3384	dioxygenase
IT777_RS03325	COG0754	glutathionylspermidine amidase activity
IT777_RS03335	COG1538	Outer membrane efflux protein
IT777_RS03340	COG0494	nUDIX hydrolase
IT777_RS03345	COG3151	Protein conserved in bacteria
IT777_RS03350	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IT777_RS03355	COG3150	esterase
IT777_RS03365	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
IT777_RS03370	COG2249	NAD(P)H dehydrogenase (quinone) activity
IT777_RS03375	COG0642	Histidine kinase
IT777_RS03385	COG3111	PFAM Bacterial OB fold (BOF) protein
IT777_RS03390	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
IT777_RS03400	COG0204	Acyl-transferase
IT777_RS03405	COG2132	Multicopper oxidase
IT777_RS03410	COG1032	radical SAM domain protein
IT777_RS03415	COG0656	L-ascorbic acid biosynthetic process
IT777_RS03420	COG1979	alcohol dehydrogenase
IT777_RS03425	COG2207	Transcriptional regulator
IT777_RS03430	COG0586	Pfam SNARE associated Golgi protein
IT777_RS03435	COG0626	cystathionine gamma-synthase activity
IT777_RS03445	COG0848	biopolymer transport protein
IT777_RS03460	COG0625	glutathione transferase activity
IT777_RS03475	COG0754	glutathionylspermidine amidase activity
IT777_RS03480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IT777_RS03500	COG0583	DNA-binding transcription factor activity
IT777_RS03505	COG0626	cystathionine gamma-synthase activity
IT777_RS03545	COG3423	Transcriptional regulator
IT777_RS03555	COG1811	Na channel or pump
IT777_RS03560	COG1982	Orn Lys Arg decarboxylase major
IT777_RS03565	COG2211	Major facilitator Superfamily
IT777_RS03580	COG1194	a g-specific adenine glycosylase
IT777_RS03590	COG3171	Protein conserved in bacteria
IT777_RS03610	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IT777_RS03615	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT777_RS03620	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IT777_RS03635	COG0762	integral membrane protein
IT777_RS03640	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IT777_RS03645	COG2805	Type II/IV secretion system protein
IT777_RS03665	COG0189	ligase activity
IT777_RS03670	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IT777_RS03675	COG2356	endonuclease I
IT777_RS03685	COG2814	Major facilitator Superfamily
IT777_RS03725	COG0501	Belongs to the peptidase M48B family
IT777_RS03730	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IT777_RS03745	COG0191	fructose-bisphosphate aldolase activity
IT777_RS03750	COG0668	transmembrane transport
IT777_RS03760	COG2968	Membrane
IT777_RS03775	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IT777_RS03780	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IT777_RS03800	COG0006	proline dipeptidase activity
IT777_RS03805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IT777_RS03810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IT777_RS03830	COG1028	Short-chain dehydrogenase reductase Sdr
IT777_RS03835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IT777_RS03855	COG2723	6-phospho-beta-galactosidase activity
IT777_RS03860	COG1737	Transcriptional regulator
IT777_RS03870	COG1272	protein, Hemolysin III
IT777_RS03880	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IT777_RS03890	COG0716	FMN binding
IT777_RS03895	COG4974	Belongs to the 'phage' integrase family
IT777_RS03905	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IT777_RS03925	COG4942	peptidase
IT777_RS03935	COG4974	Belongs to the 'phage' integrase family
IT777_RS04000	COG2814	Major facilitator Superfamily
IT777_RS04005	COG0583	DNA-binding transcription factor activity
IT777_RS04035	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IT777_RS04045	COG1393	Belongs to the ArsC family
IT777_RS04060	COG1538	Outer membrane efflux protein
IT777_RS04065	COG1289	transmembrane transporter activity
IT777_RS04080	COG3592	Divergent 4Fe-4S mono-cluster
IT777_RS04085	COG2388	GCN5-related N-acetyl-transferase
IT777_RS04090	COG3539	Fimbrial protein
IT777_RS04095	COG3539	Fimbrial protein
IT777_RS04100	COG3539	Fimbrial protein
IT777_RS04105	COG3188	usher protein
IT777_RS04110	COG3121	Chaperone
IT777_RS04115	COG3539	Fimbrial protein
IT777_RS04125	COG4974	Belongs to the 'phage' integrase family
IT777_RS04130	COG0582	viral genome integration into host DNA
IT777_RS04145	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
IT777_RS04150	COG1846	Transcriptional regulator
IT777_RS04155	COG0697	spore germination
IT777_RS04205	COG0667	Aldo Keto reductase
IT777_RS04210	COG0814	amino acid
IT777_RS04225	COG0183	Belongs to the thiolase family
IT777_RS04235	COG0823	Involved in the tonB-independent uptake of proteins
IT777_RS04240	COG1028	Short-chain dehydrogenase reductase Sdr
IT777_RS04245	COG2814	Major facilitator Superfamily
IT777_RS04280	COG3842	ATPase activity
IT777_RS04285	COG0395	ABC-type sugar transport system, permease component
IT777_RS04290	COG1175	transmembrane transport
IT777_RS04300	COG1917	Cupin 2, conserved barrel domain protein
IT777_RS04305	COG1794	racemase activity, acting on amino acids and derivatives
IT777_RS04310	COG0583	DNA-binding transcription factor activity
IT777_RS04320	COG1609	Transcriptional regulator
IT777_RS04325	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IT777_RS04330	COG2723	6-phospho-beta-galactosidase activity
IT777_RS04335	COG2186	Transcriptional regulator
IT777_RS04345	COG1609	Transcriptional regulator
IT777_RS04365	COG0667	Aldo Keto reductase
IT777_RS04375	COG0861	Integral membrane protein TerC family
IT777_RS04410	COG2165	general secretion pathway protein
IT777_RS04415	COG4795	General secretion pathway protein
IT777_RS04425	COG4967	type IV pilus modification protein PilV
IT777_RS04430	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IT777_RS04435	COG1025	Belongs to the peptidase M16 family
IT777_RS04440	COG1074	ATP-dependent DNA helicase activity
IT777_RS04445	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IT777_RS04450	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IT777_RS04450	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IT777_RS04455	COG0860	N-Acetylmuramoyl-L-alanine amidase
IT777_RS04460	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IT777_RS04490	COG4656	Part of a membrane complex involved in electron transport
IT777_RS04495	COG1012	belongs to the aldehyde dehydrogenase family
IT777_RS04495	COG1454	alcohol dehydrogenase
IT777_RS04510	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
IT777_RS04525	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
IT777_RS04690	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
IT777_RS04695	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IT777_RS04700	COG2166	iron-sulfur cluster assembly
IT777_RS04705	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IT777_RS04715	COG0583	DNA-binding transcription factor activity
IT777_RS04720	COG2363	Small membrane protein
IT777_RS04730	COG1349	DNA-binding transcription factor activity
IT777_RS04750	COG0738	Major facilitator superfamily
IT777_RS04755	COG0235	Class ii aldolase
IT777_RS04760	COG1454	alcohol dehydrogenase
IT777_RS04770	COG1760	l-serine dehydratase
IT777_RS04775	COG0814	amino acid
IT777_RS04780	COG1611	Belongs to the LOG family
IT777_RS04795	COG3098	single-species biofilm formation
IT777_RS04800	COG0564	pseudouridine synthase activity
IT777_RS04805	COG0716	FMN binding
IT777_RS04810	COG2271	Major facilitator Superfamily
IT777_RS04815	COG4948	Mandelate Racemase Muconate Lactonizing
IT777_RS04820	COG4948	Mandelate Racemase Muconate Lactonizing
IT777_RS04825	COG1929	Belongs to the glycerate kinase type-1 family
IT777_RS04830	COG4999	Histidine kinase
IT777_RS04830	COG2205	protein histidine kinase activity
IT777_RS04830	COG3437	response regulator, receiver
IT777_RS04830	COG3850	Histidine kinase
IT777_RS04840	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IT777_RS04860	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
IT777_RS04870	COG0602	queuosine metabolic process
IT777_RS04875	COG0720	synthase
IT777_RS04895	COG2234	aminopeptidase activity
IT777_RS04955	COG1388	LysM domain
IT777_RS04955	COG4942	peptidase
IT777_RS04960	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IT777_RS04985	COG0163	prenyltransferase activity
IT777_RS04990	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IT777_RS05025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IT777_RS05030	COG4558	Periplasmic binding protein
IT777_RS05035	COG3720	iron ion transport
IT777_RS05055	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IT777_RS05060	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IT777_RS05065	COG1121	(ABC) transporter
IT777_RS05070	COG0803	Belongs to the bacterial solute-binding protein 9 family
IT777_RS05080	COG0309	Hydrogenase expression formation protein (HypE)
IT777_RS05085	COG0409	Hydrogenase expression formation protein
IT777_RS05090	COG0298	carbon dioxide binding
IT777_RS05095	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IT777_RS05110	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IT777_RS05115	COG0651	ATP synthesis coupled electron transport
IT777_RS05120	COG0650	Formate hydrogenlyase subunit 4
IT777_RS05125	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
IT777_RS05125	COG3261	NADH dehydrogenase
IT777_RS05130	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IT777_RS05135	COG3260	NADH ubiquinone oxidoreductase 20
IT777_RS05145	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
IT777_RS05155	COG2723	6-phospho-beta-galactosidase activity
IT777_RS05160	COG1263	PTS System
IT777_RS05160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IT777_RS05170	COG1609	Transcriptional regulator
IT777_RS05175	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IT777_RS05180	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
IT777_RS05185	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
IT777_RS05195	COG2814	Major facilitator Superfamily
IT777_RS05205	COG1414	Transcriptional regulator
IT777_RS05210	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IT777_RS05215	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IT777_RS05240	COG1349	DNA-binding transcription factor activity
IT777_RS05245	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
IT777_RS05250	COG1028	Short-chain dehydrogenase reductase Sdr
IT777_RS05260	COG3732	PTS system glucitol sorbitol-specific
IT777_RS05265	COG3730	PTS system glucitol sorbitol-specific
IT777_RS05270	COG2951	lytic endotransglycosylase activity
IT777_RS05275	COG1121	(ABC) transporter
IT777_RS05280	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IT777_RS05285	COG0803	Belongs to the bacterial solute-binding protein 9 family
IT777_RS05290	COG1546	Belongs to the CinA family
IT777_RS05310	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IT777_RS05340	COG2823	Periplasmic or secreted lipoprotein
IT777_RS05345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IT777_RS05350	COG1238	metal cluster binding
IT777_RS05370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IT777_RS05375	COG2814	Major facilitator Superfamily
IT777_RS05380	COG1566	PFAM secretion protein HlyD family protein
IT777_RS05385	COG1846	Transcriptional regulator
IT777_RS05395	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IT777_RS05405	COG4176	ABC-type proline glycine betaine transport system permease component
IT777_RS05420	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IT777_RS05430	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IT777_RS05435	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IT777_RS05445	COG4575	ribosome binding
IT777_RS05475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IT777_RS05480	COG0640	Transcriptional regulator
IT777_RS05490	COG0583	DNA-binding transcription factor activity
IT777_RS05495	COG3284	Transcriptional regulator
IT777_RS05505	COG3539	Fimbrial protein
IT777_RS05510	COG3121	Chaperone
IT777_RS05525	COG3121	Chaperone
IT777_RS05545	COG1028	Short-chain dehydrogenase reductase Sdr
IT777_RS05555	COG0235	Class ii aldolase
IT777_RS05565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IT777_RS05595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IT777_RS05625	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
IT777_RS05645	COG0431	NADPH-dependent FMN reductase
IT777_RS05660	COG2271	Major facilitator Superfamily
IT777_RS05670	COG0477	Major facilitator Superfamily
IT777_RS05675	COG3622	Belongs to the hyi family
IT777_RS05700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IT777_RS05705	COG3708	Transcriptional regulator
IT777_RS05705	COG2207	Transcriptional regulator
IT777_RS05725	COG0662	Cupin 2, conserved barrel domain protein
IT777_RS05735	COG1028	Short-chain dehydrogenase reductase Sdr
IT777_RS05750	COG2801	Transposase and inactivated derivatives
IT777_RS05865	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IT777_RS05875	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IT777_RS05890	COG1475	DNA binding
IT777_RS05900	COG0582	viral genome integration into host DNA
IT777_RS05915	COG2867	negative regulation of translational initiation
IT777_RS05930	COG0497	DNA recombination
IT777_RS05945	COG4536	flavin adenine dinucleotide binding
IT777_RS05950	COG4137	Cytochrome C assembly protein
IT777_RS05955	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IT777_RS05990	COG2885	chlorophyll binding
IT777_RS05995	COG2199	diguanylate cyclase activity
IT777_RS06005	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IT777_RS06010	COG1605	Chorismate mutase
IT777_RS06010	COG0287	Prephenate dehydrogenase
IT777_RS06020	COG0077	Prephenate dehydratase
IT777_RS06020	COG1605	Chorismate mutase
IT777_RS06030	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IT777_RS06035	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IT777_RS06050	COG0542	response to heat
IT777_RS06075	COG0477	Major facilitator Superfamily
IT777_RS06080	COG5544	Lipoprotein
IT777_RS06085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IT777_RS06095	COG3148	PFAM DTW domain containing protein
IT777_RS06100	COG3118	belongs to the thioredoxin family
IT777_RS06105	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IT777_RS06120	COG0513	Belongs to the DEAD box helicase family
IT777_RS06130	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IT777_RS06145	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
IT777_RS06150	COG3026	antisigma factor binding
IT777_RS06155	COG3086	response to oxidative stress
IT777_RS06165	COG0681	Belongs to the peptidase S26 family
IT777_RS06185	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IT777_RS06195	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IT777_RS06200	COG1737	Transcriptional regulator
IT777_RS06205	COG0560	Phosphoserine phosphatase
IT777_RS06220	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IT777_RS06220	COG0047	phosphoribosylformylglycinamidine synthase activity
IT777_RS06225	COG2205	protein histidine kinase activity
IT777_RS06230	COG3170	Tfp pilus assembly protein FimV
IT777_RS06235	COG2204	response regulator
IT777_RS06240	COG0347	Belongs to the P(II) protein family
IT777_RS06245	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IT777_RS06245	COG1017	nitric oxide dioxygenase activity
IT777_RS06255	COG2259	Doxx family
IT777_RS06285	COG0583	DNA-binding transcription factor activity
IT777_RS06290	COG2814	Major facilitator Superfamily
IT777_RS06295	COG3711	transcriptional antiterminator
IT777_RS06300	COG3683	transport system, periplasmic component
IT777_RS06305	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
IT777_RS06330	COG0822	iron-sulfur transferase activity
IT777_RS06350	COG0633	Ferredoxin
IT777_RS06355	COG2975	iron-sulfur cluster assembly
IT777_RS06380	COG2897	thiosulfate sulfurtransferase activity
IT777_RS06385	COG2373	Large extracellular alpha-helical protein
IT777_RS06390	COG4953	penicillin-binding protein 1C
IT777_RS06420	COG2976	Protein conserved in bacteria
IT777_RS06440	COG1645	bacterial-type flagellum-dependent swarming motility
IT777_RS06450	COG0516	GMP reductase activity
IT777_RS06450	COG0517	IMP dehydrogenase activity
IT777_RS06465	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IT777_RS06480	COG2814	Major facilitator Superfamily
IT777_RS06510	COG2200	EAL domain
IT777_RS06525	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IT777_RS06540	COG2723	6-phospho-beta-galactosidase activity
IT777_RS06550	COG2233	PERMEase
IT777_RS06565	COG1393	Belongs to the ArsC family
IT777_RS06570	COG4783	chaperone-mediated protein folding
IT777_RS06580	COG0628	permease
IT777_RS06585	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IT777_RS06590	COG2716	regulation of RNA biosynthetic process
IT777_RS06600	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
IT777_RS06610	COG2321	neutral zinc metallopeptidase
IT777_RS06620	COG0400	carboxylic ester hydrolase activity
IT777_RS06635	COG1393	Belongs to the ArsC family
IT777_RS06645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IT777_RS06650	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IT777_RS06650	COG0493	'glutamate synthase
IT777_RS06660	COG5342	invasion associated locus B
IT777_RS06665	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IT777_RS06670	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IT777_RS06685	COG0860	N-Acetylmuramoyl-L-alanine amidase
IT777_RS06705	COG2837	iron assimilation
IT777_RS06715	COG4150	thiosulfate binding
IT777_RS06720	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IT777_RS06725	COG4208	sulfate ABC transporter
IT777_RS06730	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IT777_RS06740	COG4319	ketosteroid isomerase
IT777_RS06775	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IT777_RS06795	COG3530	Putative quorum-sensing-regulated virulence factor
IT777_RS06800	COG0385	Bile acid
IT777_RS06805	COG0583	DNA-binding transcription factor activity
IT777_RS06855	COG3415	Transposase
IT777_RS06860	COG3415	Transposase
IT777_RS06875	COG2200	EAL domain
IT777_RS06875	COG2199	diguanylate cyclase activity
IT777_RS06880	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IT777_RS06895	COG0667	Aldo Keto reductase
IT777_RS06900	COG3961	Belongs to the TPP enzyme family
IT777_RS06915	COG3279	Response regulator of the LytR AlgR family
IT777_RS06920	COG3275	phosphorelay sensor kinase activity
IT777_RS06930	COG0436	Aminotransferase
IT777_RS06940	COG2807	transmembrane transport
IT777_RS06945	COG0590	tRNA wobble adenosine to inosine editing
IT777_RS06950	COG0583	DNA-binding transcription factor activity
IT777_RS07035	COG2116	formate transmembrane transporter activity
IT777_RS07040	COG2853	Lipoprotein
IT777_RS07050	COG3691	Protein conserved in bacteria
IT777_RS07065	COG2062	phosphohistidine phosphatase, SixA
IT777_RS07090	COG0730	response to heat
IT777_RS07095	COG3101	peptidyl-lysine hydroxylation
IT777_RS07110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IT777_RS07130	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IT777_RS07140	COG0586	Pfam SNARE associated Golgi protein
IT777_RS07150	COG0285	dihydrofolate synthase activity
IT777_RS07155	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
IT777_RS07160	COG1286	toxin biosynthetic process
IT777_RS07165	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IT777_RS07170	COG0163	prenyltransferase activity
IT777_RS07195	COG4160	amino acid transport
IT777_RS07200	COG4598	ABC transporter
IT777_RS07215	COG1090	epimerase
IT777_RS07220	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IT777_RS07225	COG0625	glutathione transferase activity
IT777_RS07230	COG0625	glutathione transferase activity
IT777_RS07235	COG0622	Phosphoesterase
IT777_RS07240	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IT777_RS07265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IT777_RS07270	COG0490	domain, Protein
IT777_RS07270	COG0471	metal ion transport
IT777_RS07280	COG0436	Aminotransferase
IT777_RS07285	COG0583	DNA-binding transcription factor activity
IT777_RS07330	COG0839	Belongs to the complex I subunit 6 family
IT777_RS07340	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IT777_RS07345	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IT777_RS07360	COG2153	protein acetylation
IT777_RS07365	COG1169	isochorismate synthase
IT777_RS07415	COG0642	Histidine kinase
IT777_RS07425	COG5464	transposase or invertase
IT777_RS07440	COG1414	Transcriptional regulator
IT777_RS07450	COG2271	Major facilitator Superfamily
IT777_RS07460	COG0247	lactate metabolic process
IT777_RS07470	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IT777_RS07475	COG2271	Major facilitator Superfamily
IT777_RS07480	COG0584	glycerophosphoryl diester phosphodiesterase
IT777_RS07485	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IT777_RS07510	COG0784	Response regulator, receiver
IT777_RS07510	COG2205	protein histidine kinase activity
IT777_RS07520	COG2198	Histidine kinase
IT777_RS07520	COG0642	Histidine kinase
IT777_RS07535	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IT777_RS07535	COG2169	Transcriptional regulator
IT777_RS07540	COG3145	DNA-N1-methyladenine dioxygenase activity
IT777_RS07545	COG4615	Cyclic peptide transporter
IT777_RS07550	COG2239	Acts as a magnesium transporter
IT777_RS07555	COG0659	secondary active sulfate transmembrane transporter activity
IT777_RS07570	COG0628	permease
IT777_RS07595	COG1349	DNA-binding transcription factor activity
IT777_RS07600	COG0494	nUDIX hydrolase
IT777_RS07620	COG1061	Type III restriction enzyme res subunit
IT777_RS07625	COG1187	pseudouridine synthase activity
IT777_RS07630	COG2814	Major facilitator Superfamily
IT777_RS07640	COG4172	Belongs to the ABC transporter superfamily
IT777_RS07645	COG4239	(ABC) transporter, permease
IT777_RS07650	COG4174	ABC transporter (Permease)
IT777_RS07655	COG4166	transmembrane transport
IT777_RS07660	COG2200	EAL domain
IT777_RS07665	COG0791	NLP P60 protein
IT777_RS07670	COG0671	phosphoesterase, PA-phosphatase related
IT777_RS07675	COG0523	cobalamin synthesis protein
IT777_RS07680	COG0246	Mannitol dehydrogenase
IT777_RS07685	COG1312	Catalyzes the dehydration of D-mannonate
IT777_RS07710	COG1566	PFAM secretion protein HlyD family protein
IT777_RS07715	COG2814	Major facilitator Superfamily
IT777_RS07725	COG1105	Belongs to the carbohydrate kinase PfkB family
IT777_RS07730	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IT777_RS07730	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IT777_RS07730	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IT777_RS07740	COG2855	membrane
IT777_RS07745	COG0583	DNA-binding transcription factor activity
IT777_RS07750	COG0833	amino acid
IT777_RS07755	COG4771	TonB-dependent receptor
IT777_RS07770	COG2311	Membrane
IT777_RS07785	COG1129	ABC transporter
IT777_RS07795	COG2949	membrane
IT777_RS07805	COG1346	cytolysis
IT777_RS07815	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IT777_RS07820	COG3659	wide pore channel activity
IT777_RS07835	COG2723	6-phospho-beta-galactosidase activity
IT777_RS07840	COG2226	methyltransferase
IT777_RS07845	COG1538	Outer membrane efflux protein
IT777_RS07850	COG0586	Pfam SNARE associated Golgi protein
IT777_RS07860	COG1686	Belongs to the peptidase S11 family
IT777_RS07870	COG0277	FAD linked oxidase domain protein
IT777_RS07875	COG1472	Belongs to the glycosyl hydrolase 3 family
IT777_RS07880	COG1732	Glycine betaine
IT777_RS07885	COG1174	glycine betaine transport
IT777_RS07890	COG1125	glycine betaine transport
IT777_RS07895	COG1174	glycine betaine transport
IT777_RS07905	COG3275	phosphorelay sensor kinase activity
IT777_RS07915	COG4807	Protein conserved in bacteria
IT777_RS07935	COG5455	response to cobalt ion
IT777_RS07940	COG0583	DNA-binding transcription factor activity
IT777_RS07945	COG2252	PERMEase
IT777_RS07955	COG0583	DNA-binding transcription factor activity
IT777_RS07965	COG2015	COG2015, Alkyl sulfatase and related hydrolases
IT777_RS07975	COG2015	COG2015, Alkyl sulfatase and related hydrolases
IT777_RS08015	COG0351	phosphomethylpyrimidine kinase
IT777_RS08020	COG1830	Aldolase
IT777_RS08035	COG1070	Carbohydrate kinase
IT777_RS08045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IT777_RS08055	COG0826	peptidase U32
IT777_RS08060	COG0745	RESPONSE REGULATOR receiver
IT777_RS08065	COG2205	protein histidine kinase activity
IT777_RS08090	COG1301	dicarboxylic acid transport
IT777_RS08110	COG2205	protein histidine kinase activity
IT777_RS08115	COG0443	Heat shock 70 kDa protein
IT777_RS08120	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IT777_RS08135	COG2982	Protein involved in outer membrane biogenesis
IT777_RS08140	COG1253	flavin adenine dinucleotide binding
IT777_RS08180	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IT777_RS08205	COG0438	transferase activity, transferring glycosyl groups
IT777_RS08295	COG0438	transferase activity, transferring glycosyl groups
IT777_RS08320	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IT777_RS08350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IT777_RS08355	COG0583	DNA-binding transcription factor activity
IT777_RS08365	COG0531	amino acid
IT777_RS08380	COG3604	Transcriptional regulator
IT777_RS08385	COG2205	protein histidine kinase activity
IT777_RS08470	COG0640	Transcriptional regulator
IT777_RS08475	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IT777_RS08480	COG2925	Exonuclease
IT777_RS08495	COG1289	transmembrane transporter activity
IT777_RS08515	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IT777_RS08525	COG1942	4-Oxalocrotonate Tautomerase
IT777_RS08530	COG0583	DNA-binding transcription factor activity
IT777_RS08535	COG0095	Lipoate-protein ligase
IT777_RS08540	COG0477	Major facilitator Superfamily
IT777_RS08550	COG5001	Diguanylate cyclase
IT777_RS08550	COG3300	MHYT domain
IT777_RS08555	COG3615	Tellurite resistance protein tehB
IT777_RS08580	COG3706	GGDEF domain
IT777_RS08595	COG0534	Mate efflux family protein
IT777_RS08640	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IT777_RS08660	COG0604	alcohol dehydrogenase
IT777_RS08665	COG1309	transcriptional regulator
IT777_RS08670	COG0025	NhaP-type Na H and K H
IT777_RS08690	COG1376	ErfK ybiS ycfS ynhG family protein
IT777_RS08700	COG0251	oxidation-reduction process
IT777_RS08720	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IT777_RS08730	COG1418	mRNA catabolic process
IT777_RS08735	COG0270	DNA (cytosine-5-)-methyltransferase activity
IT777_RS08740	COG3727	T/G mismatch-specific endonuclease activity
IT777_RS08745	COG0697	spore germination
IT777_RS08750	COG2354	Protein conserved in bacteria
IT777_RS08755	COG3706	GGDEF domain
IT777_RS08780	COG0366	Alpha amylase catalytic
IT777_RS08785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IT777_RS08795	COG0765	amino acid transport
IT777_RS08800	COG1126	abc transporter atp-binding protein
IT777_RS08805	COG2197	response regulator
IT777_RS08815	COG2197	response regulator
IT777_RS08900	COG1403	HNH endonuclease
IT777_RS08930	COG3772	lysozyme
IT777_RS08970	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IT777_RS09000	COG0431	NADPH-dependent FMN reductase
IT777_RS09020	COG3012	SEC-C Motif Domain Protein
IT777_RS09020	COG3318	Belongs to the UPF0149 family
IT777_RS09025	COG0814	amino acid
IT777_RS09035	COG1528	Iron-storage protein
IT777_RS09050	COG0477	Major facilitator Superfamily
IT777_RS09060	COG2211	Major facilitator Superfamily
IT777_RS09060	COG2211	Major facilitator Superfamily
IT777_RS09070	COG1528	Iron-storage protein
IT777_RS09075	COG1879	ABC-type sugar transport system periplasmic component
IT777_RS09085	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT777_RS09110	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
IT777_RS09120	COG3102	Protein conserved in bacteria
IT777_RS09140	COG3788	relative of glutathione S-transferase, MAPEG superfamily
IT777_RS09145	COG1801	Protein of unknown function DUF72
IT777_RS09150	COG1335	isochorismatase
IT777_RS09160	COG0494	nUDIX hydrolase
IT777_RS09185	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IT777_RS09195	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
IT777_RS09200	COG0739	heme binding
IT777_RS09205	COG1560	Kdo2-lipid A biosynthetic process
IT777_RS09225	COG3493	citrate carrier protein
IT777_RS09235	COG1737	Transcriptional regulator
IT777_RS09245	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IT777_RS09250	COG0129	dihydroxy-acid dehydratase activity
IT777_RS09255	COG0800	Aldolase
IT777_RS09265	COG3141	response to X-ray
IT777_RS09275	COG2979	Protein of unknown function (DUF533)
IT777_RS09280	COG1770	oligopeptidase
IT777_RS09285	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IT777_RS09295	COG2372	response to copper ion
IT777_RS09300	COG1276	copper resistance
IT777_RS09315	COG2990	Protein conserved in bacteria
IT777_RS09340	COG3008	intermembrane lipid transfer
IT777_RS09345	COG2995	paraquat-inducible protein a
IT777_RS09350	COG1956	GAF domain-containing protein
IT777_RS09370	COG2814	Major facilitator Superfamily
IT777_RS09375	COG1414	Transcriptional regulator
IT777_RS09405	COG0768	penicillin binding
IT777_RS09410	COG2226	methyltransferase
IT777_RS09425	COG3716	PTS system mannose fructose sorbose family IID component
IT777_RS09430	COG3715	PTS system
IT777_RS09435	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IT777_RS09435	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IT777_RS09440	COG1253	flavin adenine dinucleotide binding
IT777_RS09445	COG2200	EAL domain
IT777_RS09450	COG1760	l-serine dehydratase
IT777_RS09470	COG0251	oxidation-reduction process
IT777_RS09475	COG1199	ATP-dependent helicase activity
IT777_RS09480	COG1214	PFAM Peptidase M22, glycoprotease
IT777_RS09485	COG3065	identical protein binding
IT777_RS09495	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IT777_RS09505	COG2894	cell division
IT777_RS09520	COG0179	Fumarylacetoacetate (FAA) hydrolase
IT777_RS09550	COG2719	SpoVR family
IT777_RS09575	COG1619	proteins homologs of microcin C7 resistance protein MccF
IT777_RS09585	COG4774	siderophore transport
IT777_RS09595	COG2308	Evidence 4 Homologs of previously reported genes of
IT777_RS09630	COG0583	DNA-binding transcription factor activity
IT777_RS09635	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IT777_RS09650	COG1882	Formate acetyltransferase
IT777_RS09685	COG0583	DNA-binding transcription factor activity
IT777_RS09725	COG0564	pseudouridine synthase activity
IT777_RS09730	COG3122	Protein conserved in bacteria
IT777_RS09765	COG0012	GTP binding
IT777_RS09785	COG0659	secondary active sulfate transmembrane transporter activity
IT777_RS09815	COG2890	protein-(glutamine-N5) methyltransferase activity
IT777_RS09835	COG0387	Pfam Sodium calcium exchanger
IT777_RS09840	COG4572	Cation transport regulator
IT777_RS09845	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
IT777_RS09855	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
IT777_RS09860	COG3707	response regulator
IT777_RS09865	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IT777_RS09875	COG1116	anion transmembrane transporter activity
IT777_RS09880	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IT777_RS09880	COG2146	nitrite reductase [NAD(P)H] activity
IT777_RS09885	COG0243	molybdopterin cofactor binding
IT777_RS09890	COG4932	domain protein
IT777_RS09895	COG2197	response regulator
IT777_RS09900	COG3850	Histidine kinase
IT777_RS09905	COG2223	nitrite transmembrane transporter activity
IT777_RS09910	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IT777_RS09915	COG1140	nitrate reductase beta subunit
IT777_RS09920	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
IT777_RS09925	COG2181	nitrate reductase activity
IT777_RS09935	COG1522	sequence-specific DNA binding
IT777_RS09965	COG0788	formyltetrahydrofolate deformylase activity
IT777_RS09975	COG1752	Esterase of the alpha-beta hydrolase superfamily
IT777_RS09980	COG0745	RESPONSE REGULATOR receiver
IT777_RS09985	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IT777_RS09990	COG2916	Histone family protein nucleoid-structuring protein H-NS
IT777_RS10005	COG1012	belongs to the aldehyde dehydrogenase family
IT777_RS10005	COG1454	alcohol dehydrogenase
IT777_RS10015	COG2095	MarC family integral membrane protein
IT777_RS10020	COG4166	transmembrane transport
IT777_RS10025	COG0601	transmembrane transport
IT777_RS10030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IT777_RS10035	COG0444	Belongs to the ABC transporter superfamily
IT777_RS10045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IT777_RS10065	COG2353	YceI-like domain
IT777_RS10070	COG2350	Protein conserved in bacteria
IT777_RS10080	COG3001	Fructosamine kinase
IT777_RS10090	COG1105	Belongs to the carbohydrate kinase PfkB family
IT777_RS10095	COG3137	Salt-induced outer membrane protein
IT777_RS10135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IT777_RS10135	COG0072	phenylalanine-tRNA ligase activity
IT777_RS10155	COG0583	DNA-binding transcription factor activity
IT777_RS10175	COG0386	Belongs to the glutathione peroxidase family
IT777_RS10185	COG0791	NLP P60 protein
IT777_RS10195	COG4256	Hemin uptake protein
IT777_RS10200	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IT777_RS10215	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IT777_RS10215	COG0574	Belongs to the PEP-utilizing enzyme family
IT777_RS10225	COG0628	permease
IT777_RS10230	COG0277	FAD linked oxidase domain protein
IT777_RS10230	COG0247	lactate metabolic process
IT777_RS10235	COG2050	protein possibly involved in aromatic compounds catabolism
IT777_RS10240	COG2261	transglycosylase associated protein
IT777_RS10265	COG1120	ATPase activity
IT777_RS10270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IT777_RS10280	COG0583	DNA-binding transcription factor activity
IT777_RS10305	COG1304	FMN binding
IT777_RS10315	COG0316	Belongs to the HesB IscA family
IT777_RS10320	COG0719	Fe-S assembly protein
IT777_RS10325	COG0396	ATPase activity
IT777_RS10330	COG0719	Fe-S assembly protein
IT777_RS10345	COG1376	ErfK ybiS ycfS ynhG family protein
IT777_RS10370	COG1309	transcriptional regulator
IT777_RS10375	COG1082	Xylose isomerase domain protein TIM barrel
IT777_RS10375	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IT777_RS10380	COG2271	Major facilitator Superfamily
IT777_RS10385	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IT777_RS10390	COG1414	Transcriptional regulator
IT777_RS10425	COG2814	Major facilitator Superfamily
IT777_RS10445	COG0583	DNA-binding transcription factor activity
IT777_RS10470	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IT777_RS10475	COG1116	anion transmembrane transporter activity
IT777_RS10480	COG4774	siderophore transport
IT777_RS10485	COG1120	ATPase activity
IT777_RS10490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IT777_RS10495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IT777_RS10515	COG0765	amino acid transport
IT777_RS10520	COG1126	abc transporter atp-binding protein
IT777_RS10550	COG3383	formate dehydrogenase (NAD+) activity
IT777_RS10555	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IT777_RS10565	COG1175	transmembrane transport
IT777_RS10595	COG4133	protoheme IX ABC transporter activity
IT777_RS10600	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IT777_RS10605	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IT777_RS10620	COG1138	Cytochrome C-type biogenesis protein
IT777_RS10625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IT777_RS10630	COG4235	cytochrome complex assembly
IT777_RS10630	COG3088	subunit of a heme lyase
IT777_RS10645	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
IT777_RS10670	COG1028	Short-chain dehydrogenase reductase Sdr
IT777_RS10675	COG2610	gluconate transmembrane transporter activity
IT777_RS10680	COG1250	3-hydroxyacyl-CoA dehydrogenase
IT777_RS10690	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IT777_RS10700	COG0583	DNA-binding transcription factor activity
IT777_RS10730	COG2814	Major facilitator Superfamily
IT777_RS10750	COG0277	FAD linked oxidase domain protein
IT777_RS10755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IT777_RS10780	COG0402	S-adenosylhomocysteine deaminase activity
IT777_RS10845	COG4608	Belongs to the ABC transporter superfamily
IT777_RS10850	COG0444	Belongs to the ABC transporter superfamily
IT777_RS10875	COG0346	lactoylglutathione lyase activity
IT777_RS10880	COG1349	DNA-binding transcription factor activity
IT777_RS10895	COG0604	alcohol dehydrogenase
IT777_RS10895	COG1028	Short-chain dehydrogenase reductase Sdr
IT777_RS10895	COG3321	synthase
IT777_RS10920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IT777_RS10940	COG0300	oxidoreductase activity
IT777_RS10950	COG3179	chitinase
IT777_RS11010	COG0307	riboflavin synthase, alpha
IT777_RS11015	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IT777_RS11020	COG2814	Major facilitator Superfamily
IT777_RS11025	COG0583	DNA-binding transcription factor activity
IT777_RS11040	COG2814	Major facilitator Superfamily
IT777_RS11055	COG0791	NLP P60 protein
IT777_RS11060	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IT777_RS11070	COG0346	lactoylglutathione lyase activity
IT777_RS11075	COG1902	pentaerythritol trinitrate reductase activity
IT777_RS11080	COG1309	transcriptional regulator
IT777_RS11085	COG3313	Fe-S protein
IT777_RS11090	COG4989	oxidoreductase activity
IT777_RS11095	COG2032	superoxide dismutase activity
IT777_RS11100	COG1289	transmembrane transporter activity
IT777_RS11105	COG1566	PFAM secretion protein HlyD family protein
IT777_RS11120	COG3706	GGDEF domain
IT777_RS11135	COG3895	Periplasmic Protein
IT777_RS11155	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IT777_RS11160	COG0625	glutathione transferase activity
IT777_RS11170	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IT777_RS11180	COG4659	FMN binding
IT777_RS11215	COG2723	6-phospho-beta-galactosidase activity
IT777_RS11225	COG0673	inositol 2-dehydrogenase activity
IT777_RS11245	COG3038	cytochrome b561
IT777_RS11265	COG0583	DNA-binding transcription factor activity
IT777_RS11270	COG3485	protocatechuate 3,4-dioxygenase
IT777_RS11275	COG3485	protocatechuate 3,4-dioxygenase
IT777_RS11280	COG5383	Protein conserved in bacteria
IT777_RS11285	COG2272	Belongs to the type-B carboxylesterase lipase family
IT777_RS11295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IT777_RS11300	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IT777_RS11305	COG1275	C4-dicarboxylate transporter malic acid transport protein
IT777_RS11310	COG0500	methyltransferase
IT777_RS11325	COG2207	Transcriptional regulator
IT777_RS11325	COG3708	Transcriptional regulator
IT777_RS11330	COG3135	benzoate transporter
IT777_RS11335	COG1396	sequence-specific DNA binding
IT777_RS11345	COG0826	peptidase U32
IT777_RS11365	COG1294	oxidase, subunit
IT777_RS11370	COG1271	oxidase subunit
IT777_RS11375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IT777_RS11380	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IT777_RS11385	COG3842	ATPase activity
IT777_RS11390	COG1176	ABC-type spermidine putrescine transport system, permease component I
IT777_RS11395	COG1177	transmembrane transport
IT777_RS11400	COG1012	belongs to the aldehyde dehydrogenase family
IT777_RS11435	COG0747	negative chemotaxis
IT777_RS11445	COG3238	Protein conserved in bacteria
IT777_RS11450	COG1247	-acetyltransferase
IT777_RS11460	COG2130	NADP-dependent
IT777_RS11470	COG3691	Protein conserved in bacteria
IT777_RS11475	COG4772	TonB-dependent receptor
IT777_RS11495	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IT777_RS11500	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IT777_RS11505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IT777_RS11510	COG1473	amidohydrolase
IT777_RS11515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IT777_RS11520	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IT777_RS11530	COG0765	amino acid transport
IT777_RS11535	COG1126	abc transporter atp-binding protein
IT777_RS11545	COG0625	glutathione transferase activity
IT777_RS11565	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IT777_RS11570	COG3842	ATPase activity
IT777_RS11575	COG1840	ABC-type Fe3 transport system, periplasmic component
IT777_RS11580	COG1178	ABC-type Fe3 transport system permease component
IT777_RS11585	COG2162	N-hydroxyarylamine O-acetyltransferase activity
IT777_RS11590	COG2181	nitrate reductase activity
IT777_RS11595	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
IT777_RS11600	COG1140	nitrate reductase beta subunit
IT777_RS11605	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IT777_RS11625	COG1414	Transcriptional regulator
IT777_RS11630	COG4948	Mandelate Racemase Muconate Lactonizing
IT777_RS11635	COG4829	muconolactone delta-isomerase
IT777_RS11640	COG3485	protocatechuate 3,4-dioxygenase
IT777_RS11665	COG0697	spore germination
IT777_RS11675	COG0437	4 iron, 4 sulfur cluster binding
IT777_RS11680	COG2864	formate dehydrogenase
IT777_RS11695	COG2326	polyphosphate kinase activity
IT777_RS11705	COG2814	Major facilitator Superfamily
IT777_RS11715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IT777_RS11725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IT777_RS11735	COG0747	negative chemotaxis
IT777_RS11740	COG1064	alcohol dehydrogenase
IT777_RS11755	COG0488	(ABC) transporter
IT777_RS11790	COG1028	Short-chain dehydrogenase reductase Sdr
IT777_RS11795	COG3729	General stress protein
IT777_RS11805	COG3685	Protein conserved in bacteria
IT777_RS11815	COG0366	Alpha amylase catalytic
IT777_RS11825	COG2323	membrane
IT777_RS11835	COG3111	PFAM Bacterial OB fold (BOF) protein
IT777_RS11845	COG1764	response to oxidative stress
IT777_RS11860	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IT777_RS11865	COG3781	membrane
IT777_RS11870	COG0243	molybdopterin cofactor binding
IT777_RS11875	COG0583	DNA-binding transcription factor activity
IT777_RS11880	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IT777_RS11910	COG1447	Phosphotransferase system cellobiose-specific component IIA
IT777_RS11915	COG2814	Major facilitator Superfamily
IT777_RS11920	COG1285	pathogenesis
IT777_RS11925	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IT777_RS11945	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IT777_RS11945	COG0519	Catalyzes the synthesis of GMP from XMP
IT777_RS11985	COG0596	Alpha beta hydrolase
IT777_RS12005	COG0583	DNA-binding transcription factor activity
IT777_RS12010	COG0076	glutamate decarboxylase activity
IT777_RS12015	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IT777_RS12020	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IT777_RS12025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IT777_RS12030	COG1116	anion transmembrane transporter activity
IT777_RS12035	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IT777_RS12055	COG0673	inositol 2-dehydrogenase activity
IT777_RS12065	COG1609	Transcriptional regulator
IT777_RS12070	COG3706	GGDEF domain
IT777_RS12080	COG0402	S-adenosylhomocysteine deaminase activity
IT777_RS12085	COG1953	Uracil, thiamine, allantoin
IT777_RS12120	COG0406	alpha-ribazole phosphatase activity
IT777_RS12130	COG2207	Transcriptional regulator
IT777_RS12140	COG0583	DNA-binding transcription factor activity
IT777_RS12160	COG2190	(PTS) system
IT777_RS12160	COG1263	PTS System
IT777_RS12160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IT777_RS12165	COG2723	6-phospho-beta-galactosidase activity
IT777_RS12170	COG3711	transcriptional antiterminator
IT777_RS12175	COG0583	DNA-binding transcription factor activity
IT777_RS12190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IT777_RS12210	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IT777_RS12250	COG0765	amino acid transport
IT777_RS12260	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IT777_RS12270	COG2070	2-Nitropropane dioxygenase
IT777_RS12275	COG0583	DNA-binding transcription factor activity
IT777_RS12285	COG1902	pentaerythritol trinitrate reductase activity
IT777_RS12290	COG4529	Protein conserved in bacteria
IT777_RS12295	COG0477	Major facilitator Superfamily
IT777_RS12325	COG2223	nitrite transmembrane transporter activity
IT777_RS12355	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IT777_RS12365	COG3665	Urea carboxylase-associated protein
IT777_RS12370	COG0439	Biotin carboxylase
IT777_RS12420	COG0714	Associated with various cellular activities
IT777_RS12425	COG0641	radical SAM
IT777_RS12440	COG0583	DNA-binding transcription factor activity
IT777_RS12450	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IT777_RS12465	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT777_RS12475	COG1609	Transcriptional regulator
IT777_RS12500	COG1652	LysM domain
IT777_RS12555	COG2186	Transcriptional regulator
IT777_RS12560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IT777_RS12560	COG1263	PTS System
IT777_RS12570	COG2814	Major facilitator Superfamily
IT777_RS12575	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IT777_RS12575	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IT777_RS12580	COG2819	hydrolase of the alpha beta superfamily
IT777_RS12585	COG5001	Diguanylate cyclase
IT777_RS12585	COG3300	MHYT domain
IT777_RS12615	COG3121	Chaperone
IT777_RS12630	COG1649	PFAM Uncharacterised BCR, COG1649
IT777_RS12635	COG3550	peptidyl-serine autophosphorylation
IT777_RS12640	COG1396	sequence-specific DNA binding
IT777_RS12645	COG2351	hydroxyisourate hydrolase activity
IT777_RS12650	COG3195	allantoin biosynthetic process
IT777_RS12650	COG3648	Uricase
IT777_RS12655	COG2233	PERMEase
IT777_RS12685	COG2207	Transcriptional regulator
IT777_RS12700	COG4628	conserved protein (DUF2132)
IT777_RS12720	COG2011	ABC-type metal ion transport system permease component
IT777_RS12785	COG2199	diguanylate cyclase activity
IT777_RS12800	COG1012	belongs to the aldehyde dehydrogenase family
IT777_RS12805	COG0583	DNA-binding transcription factor activity
IT777_RS12815	COG0039	L-malate dehydrogenase activity
IT777_RS12820	COG1349	DNA-binding transcription factor activity
IT777_RS12825	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IT777_RS12830	COG3395	kinase activity
IT777_RS12840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IT777_RS12855	COG2731	YhcH YjgK YiaL family protein
IT777_RS12860	COG0300	oxidoreductase activity
IT777_RS12885	COG4977	sequence-specific DNA binding
IT777_RS12895	COG0697	spore germination
IT777_RS12900	COG2814	Major facilitator Superfamily
IT777_RS12935	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IT777_RS12970	COG2223	nitrite transmembrane transporter activity
IT777_RS12975	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IT777_RS12990	COG1349	DNA-binding transcription factor activity
IT777_RS12995	COG2084	Dehydrogenase
IT777_RS13000	COG3395	kinase activity
IT777_RS13005	COG0235	Class ii aldolase
IT777_RS13010	COG3622	Belongs to the hyi family
IT777_RS13015	COG2610	gluconate transmembrane transporter activity
IT777_RS13020	COG2207	Transcriptional regulator
IT777_RS13020	COG3708	Transcriptional regulator
IT777_RS13035	COG2200	EAL domain
IT777_RS13040	COG1546	Belongs to the CinA family
IT777_RS13045	COG0071	Belongs to the small heat shock protein (HSP20) family
IT777_RS13065	COG2135	peptidase activity
IT777_RS13070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IT777_RS13105	COG4221	oxidoreductase activity
IT777_RS13110	COG1802	Transcriptional regulator
IT777_RS13120	COG0246	Mannitol dehydrogenase
IT777_RS13125	COG2271	Major facilitator Superfamily
IT777_RS13140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IT777_RS13155	COG0243	molybdopterin cofactor binding
IT777_RS13160	COG0437	4 iron, 4 sulfur cluster binding
IT777_RS13165	COG3302	dmso reductase anchor subunit
IT777_RS13180	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IT777_RS13185	COG1940	carbohydrate kinase activity
IT777_RS13190	COG0583	DNA-binding transcription factor activity
IT777_RS13195	COG2814	Major facilitator Superfamily
IT777_RS13200	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
IT777_RS13210	COG3591	Belongs to the peptidase S1B family
IT777_RS13230	COG0628	permease
IT777_RS13260	COG0679	Auxin Efflux Carrier
IT777_RS13270	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IT777_RS13295	COG3290	protein histidine kinase activity
IT777_RS13300	COG4565	transcriptional regulatory protein
IT777_RS13320	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IT777_RS13320	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IT777_RS13330	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IT777_RS13335	COG0596	Alpha beta hydrolase
IT777_RS13345	COG0183	Belongs to the thiolase family
IT777_RS13350	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IT777_RS13360	COG1414	Transcriptional regulator
IT777_RS13365	COG2840	Smr protein MutS2
IT777_RS13370	COG0583	DNA-binding transcription factor activity
IT777_RS13380	COG1473	amidohydrolase
IT777_RS13385	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IT777_RS13400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IT777_RS13415	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IT777_RS13420	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IT777_RS13435	COG0531	amino acid
IT777_RS13445	COG3136	membrane protein required for alginate biosynthesis
IT777_RS13450	COG0745	RESPONSE REGULATOR receiver
IT777_RS13460	COG2205	protein histidine kinase activity
IT777_RS13470	COG0114	fumarate hydratase activity
IT777_RS13475	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IT777_RS13475	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IT777_RS13480	COG1482	cell wall glycoprotein biosynthetic process
IT777_RS13485	COG5339	Protein conserved in bacteria
IT777_RS13520	COG0425	Belongs to the sulfur carrier protein TusA family
IT777_RS13525	COG5562	phage envelope protein
IT777_RS13530	COG0401	homolog of Blt101
IT777_RS13535	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IT777_RS13540	COG1012	belongs to the aldehyde dehydrogenase family
IT777_RS13550	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IT777_RS13555	COG0477	Major facilitator Superfamily
IT777_RS13560	COG1113	amino acid transport
IT777_RS13565	COG2988	succinylglutamate desuccinylase activity
IT777_RS13570	COG3724	N-succinylarginine dihydrolase activity
IT777_RS13575	COG1012	belongs to the aldehyde dehydrogenase family
IT777_RS13580	COG3138	arginine N-succinyltransferase
IT777_RS13585	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IT777_RS13595	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IT777_RS13610	COG0183	Belongs to the thiolase family
IT777_RS13620	COG0667	Aldo Keto reductase
IT777_RS13625	COG2814	Major facilitator Superfamily
IT777_RS13630	COG0667	Aldo Keto reductase
IT777_RS13635	COG0583	DNA-binding transcription factor activity
IT777_RS13660	COG4122	O-methyltransferase activity
IT777_RS13665	COG1643	Atp-dependent helicase
IT777_RS13680	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IT777_RS13685	COG3327	negative regulation of DNA-templated transcription, initiation
IT777_RS13690	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
IT777_RS13695	COG0183	Belongs to the thiolase family
IT777_RS13700	COG2050	protein possibly involved in aromatic compounds catabolism
IT777_RS13705	COG1250	3-hydroxyacyl-CoA dehydrogenase
IT777_RS13710	COG1024	Enoyl-CoA hydratase
IT777_RS13715	COG1024	Enoyl-CoA hydratase
IT777_RS13720	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IT777_RS13725	COG2151	metal-sulfur cluster biosynthetic enzyme
IT777_RS13730	COG3396	Phenylacetate-CoA oxygenase
IT777_RS13735	COG3460	Phenylacetate-CoA oxygenase
IT777_RS13740	COG3396	Phenylacetate-CoA oxygenase
IT777_RS13745	COG2030	dehydratase
IT777_RS13745	COG1012	belongs to the aldehyde dehydrogenase family
IT777_RS13780	COG2072	flavoprotein involved in K transport
IT777_RS13785	COG0583	DNA-binding transcription factor activity
IT777_RS13790	COG1126	abc transporter atp-binding protein
IT777_RS13800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IT777_RS13815	COG1012	belongs to the aldehyde dehydrogenase family
IT777_RS13820	COG2207	Transcriptional regulator
IT777_RS13825	COG3784	Protein of unknown function (DUF1318)
IT777_RS13835	COG2911	Protein conserved in bacteria
IT777_RS13840	COG0586	Pfam SNARE associated Golgi protein
IT777_RS13845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IT777_RS13850	COG3187	Heat shock protein
IT777_RS13855	COG3042	response to heat
IT777_RS13860	COG1013	pyruvate-flavodoxin oxidoreductase activity
IT777_RS13860	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IT777_RS13860	COG0674	pyruvate-flavodoxin oxidoreductase activity
IT777_RS13860	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IT777_RS13865	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IT777_RS13875	COG0589	response to stress
IT777_RS13900	COG0513	Belongs to the DEAD box helicase family
IT777_RS13910	COG1349	DNA-binding transcription factor activity
IT777_RS13915	COG0673	inositol 2-dehydrogenase activity
IT777_RS13925	COG1113	amino acid transport
IT777_RS13930	COG1522	sequence-specific DNA binding
IT777_RS13940	COG1448	Aminotransferase
IT777_RS13945	COG2011	ABC-type metal ion transport system permease component
IT777_RS13950	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IT777_RS13960	COG0436	Aminotransferase
IT777_RS13990	COG0583	DNA-binding transcription factor activity
IT777_RS14010	COG1028	Short-chain dehydrogenase reductase Sdr
IT777_RS14045	COG2885	chlorophyll binding
IT777_RS14070	COG0693	protein deglycase activity
IT777_RS14075	COG1028	Short-chain dehydrogenase reductase Sdr
IT777_RS14080	COG0583	DNA-binding transcription factor activity
IT777_RS14115	COG0784	Response regulator, receiver
IT777_RS14115	COG2205	protein histidine kinase activity
IT777_RS14115	COG5002	protein histidine kinase activity
IT777_RS14120	COG3250	beta-galactosidase activity
IT777_RS14125	COG0656	L-ascorbic acid biosynthetic process
IT777_RS14150	COG4166	transmembrane transport
IT777_RS14160	COG2866	Carboxypeptidase
IT777_RS14165	COG4948	Mandelate Racemase Muconate Lactonizing
IT777_RS14170	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IT777_RS14175	COG3180	Ammonia monooxygenase
IT777_RS14185	COG1486	melibiose metabolic process
IT777_RS14190	COG0583	DNA-binding transcription factor activity
IT777_RS14200	COG3106	COG3106 Predicted ATPase
IT777_RS14210	COG1983	PspC domain protein
IT777_RS14220	COG1842	Phage shock protein A
IT777_RS14225	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IT777_RS14235	COG1473	amidohydrolase
IT777_RS14250	COG0702	epimerase
IT777_RS14265	COG2135	peptidase activity
IT777_RS14270	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IT777_RS14275	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IT777_RS14280	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IT777_RS14485	COG4171	peptide transport system, permease
IT777_RS14500	COG2986	histidine ammonia-lyase
IT777_RS14535	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IT777_RS14535	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IT777_RS14550	COG1349	DNA-binding transcription factor activity
IT777_RS14560	COG0023	Translation Initiation Factor
IT777_RS14570	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IT777_RS14575	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
IT777_RS14580	COG0671	phosphoesterase, PA-phosphatase related
IT777_RS14590	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IT777_RS14615	COG0616	signal peptide processing
IT777_RS14620	COG1028	Short-chain dehydrogenase reductase Sdr
IT777_RS14625	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
IT777_RS14640	COG0009	L-threonylcarbamoyladenylate synthase
IT777_RS14650	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IT777_RS14655	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IT777_RS14655	COG0512	Glutamine amidotransferase of anthranilate synthase
IT777_RS14660	COG0134	indole-3-glycerol-phosphate synthase activity
IT777_RS14660	COG0135	phosphoribosylanthranilate isomerase activity
IT777_RS14705	COG4774	siderophore transport
IT777_RS14715	COG3047	cAMP biosynthetic process
IT777_RS14720	COG0727	PFAM Uncharacterised protein family (UPF0153)
IT777_RS14745	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IT777_RS14750	COG1028	Short-chain dehydrogenase reductase Sdr
IT777_RS14755	COG1988	membrane-bound metal-dependent
IT777_RS14760	COG1823	symporter activity
IT777_RS14770	COG0753	catalase activity
IT777_RS14780	COG1486	melibiose metabolic process
IT777_RS14785	COG1917	Cupin 2, conserved barrel domain protein
IT777_RS14785	COG2169	Transcriptional regulator
IT777_RS14790	COG1447	Phosphotransferase system cellobiose-specific component IIA
IT777_RS14795	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IT777_RS14805	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IT777_RS14810	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IT777_RS14820	COG0322	excinuclease ABC activity
IT777_RS14825	COG3678	ATP-independent chaperone mediated protein folding
IT777_RS14835	COG3724	N-succinylarginine dihydrolase activity
IT777_RS14845	COG3138	arginine N-succinyltransferase
IT777_RS14855	COG0708	Exodeoxyribonuclease III
IT777_RS14860	COG0398	Pfam SNARE associated Golgi protein
IT777_RS14865	COG0398	Pfam SNARE associated Golgi protein
IT777_RS14870	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IT777_RS14875	COG4134	Bacterial extracellular solute-binding protein
IT777_RS14880	COG4135	transport system, permease component
IT777_RS14885	COG4136	ATPase activity
IT777_RS14890	COG2897	thiosulfate sulfurtransferase activity
IT777_RS14895	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IT777_RS14900	COG0494	nUDIX hydrolase
IT777_RS14905	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IT777_RS14915	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IT777_RS14920	COG0709	Synthesizes selenophosphate from selenide and ATP
IT777_RS14930	COG0778	Nitroreductase
IT777_RS14935	COG0616	signal peptide processing
IT777_RS14940	COG0252	asparaginase activity
IT777_RS14945	COG1335	isochorismatase
IT777_RS14960	COG3139	Protein of unknown function (DUF1315)
IT777_RS14980	COG0656	L-ascorbic acid biosynthetic process
IT777_RS14985	COG3713	MltA-interacting MipA family protein
IT777_RS14990	COG2766	serine protein kinase
IT777_RS15005	COG0386	Belongs to the glutathione peroxidase family
IT777_RS15035	COG1126	abc transporter atp-binding protein
IT777_RS15040	COG0765	amino acid transport
IT777_RS15045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IT777_RS15055	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IT777_RS15065	COG0583	DNA-binding transcription factor activity
IT777_RS15070	COG1902	pentaerythritol trinitrate reductase activity
IT777_RS15080	COG1028	Short-chain dehydrogenase reductase Sdr
IT777_RS15085	COG0583	DNA-binding transcription factor activity
IT777_RS15090	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IT777_RS15095	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IT777_RS15105	COG0859	PFAM glycosyl transferase family 9
IT777_RS15110	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IT777_RS15120	COG2207	Transcriptional regulator
IT777_RS15125	COG2807	transmembrane transport
IT777_RS15130	COG0504	CTP synthase activity
IT777_RS15135	COG1683	Conserved Protein
IT777_RS15140	COG3189	MarR family transcriptional regulator
IT777_RS15145	COG3042	response to heat
IT777_RS15150	COG2203	Gaf domain
IT777_RS15150	COG2199	diguanylate cyclase activity
IT777_RS15170	COG3182	Iron-regulated membrane protein
IT777_RS15180	COG1560	Kdo2-lipid A biosynthetic process
IT777_RS15190	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IT777_RS15195	COG3706	GGDEF domain
IT777_RS15200	COG0583	DNA-binding transcription factor activity
IT777_RS15205	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IT777_RS15215	COG2771	luxR family
IT777_RS15215	COG2200	EAL domain
IT777_RS15235	COG2207	Transcriptional regulator
IT777_RS15250	COG1566	PFAM secretion protein HlyD family protein
IT777_RS15255	COG1294	oxidase, subunit
IT777_RS15260	COG1271	oxidase subunit
IT777_RS15265	COG3546	catalase activity
IT777_RS15270	COG3685	Protein conserved in bacteria
IT777_RS15275	COG3685	Protein conserved in bacteria
IT777_RS15280	COG3729	General stress protein
IT777_RS15285	COG1063	alcohol dehydrogenase
IT777_RS15290	COG3813	Protein conserved in bacteria
IT777_RS15320	COG0640	Transcriptional regulator
IT777_RS15325	COG0538	isocitrate dehydrogenase activity
IT777_RS15345	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IT777_RS15350	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IT777_RS15360	COG0538	isocitrate dehydrogenase activity
IT777_RS15365	COG1187	pseudouridine synthase activity
IT777_RS15385	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IT777_RS15405	COG2205	protein histidine kinase activity
IT777_RS15410	COG2850	peptidyl-arginine hydroxylation
IT777_RS15430	COG1177	transmembrane transport
IT777_RS15445	COG0318	PFAM AMP-dependent synthetase and ligase
IT777_RS15455	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IT777_RS15465	COG4591	ABC-type transport system involved in lipoprotein release permease component
IT777_RS15470	COG1136	(ABC) transporter
IT777_RS15475	COG4591	ABC-type transport system involved in lipoprotein release permease component
IT777_RS15485	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IT777_RS15490	COG1388	LysM domain
IT777_RS15490	COG1376	ErfK ybiS ycfS ynhG family protein
IT777_RS15505	COG1309	transcriptional regulator
IT777_RS15520	COG3134	Outer membrane lipoprotein
IT777_RS15525	COG1252	NADH dehydrogenase
IT777_RS15540	COG0510	thiamine kinase activity
IT777_RS15550	COG5633	Lipoprotein
IT777_RS15555	COG0537	adenosine 5'-monophosphoramidase activity
IT777_RS15565	COG0084	hydrolase, TatD family'
IT777_RS15570	COG0470	DNA polymerase III
IT777_RS15580	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IT777_RS15585	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IT777_RS15590	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IT777_RS15605	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IT777_RS15625	COG1399	metal-binding, possibly nucleic acid-binding protein
IT777_RS15630	COG0424	maF-like protein
IT777_RS15645	COG1530	ribonuclease E activity
IT777_RS15650	COG0583	DNA-binding transcription factor activity
IT777_RS15655	COG2814	Major facilitator Superfamily
IT777_RS15660	COG0728	peptidoglycan biosynthetic process
IT777_RS15675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IT777_RS15720	COG1560	Kdo2-lipid A biosynthetic process
IT777_RS15735	COG5645	(Lipo)protein
IT777_RS15770	COG3381	protein complex oligomerization
IT777_RS15790	COG0583	DNA-binding transcription factor activity
IT777_RS15800	COG1335	isochorismatase
IT777_RS15820	COG1702	phosphate starvation-inducible protein PhoH
IT777_RS15840	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IT777_RS15850	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IT777_RS15865	COG1309	transcriptional regulator
IT777_RS15900	COG2233	PERMEase
IT777_RS15910	COG3729	General stress protein
IT777_RS15950	COG0531	amino acid
IT777_RS15955	COG0174	glutamine synthetase
IT777_RS15960	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IT777_RS15965	COG1396	sequence-specific DNA binding
IT777_RS15965	COG1917	Cupin 2, conserved barrel domain protein
IT777_RS15970	COG1012	belongs to the aldehyde dehydrogenase family
IT777_RS15975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IT777_RS15980	COG0583	DNA-binding transcription factor activity
IT777_RS15985	COG0473	3-isopropylmalate dehydrogenase activity
IT777_RS16000	COG1028	Short-chain dehydrogenase reductase Sdr
IT777_RS16005	COG1053	succinate dehydrogenase
IT777_RS16010	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IT777_RS16010	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IT777_RS16010	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IT777_RS16015	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IT777_RS16020	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IT777_RS16025	COG1882	Formate acetyltransferase
IT777_RS16030	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IT777_RS16035	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IT777_RS16045	COG2207	Transcriptional regulator
IT777_RS16050	COG3706	GGDEF domain
IT777_RS16070	COG2200	EAL domain
IT777_RS16080	COG0058	SHG alpha-glucan phosphorylase activity
IT777_RS16095	COG0670	Belongs to the BI1 family
IT777_RS16110	COG2207	Transcriptional regulator
IT777_RS16115	COG1881	PFAM PEBP family protein
IT777_RS16130	COG1832	CoA-binding protein
IT777_RS16140	COG0210	DNA helicase
IT777_RS16145	COG3304	Inner membrane component domain
IT777_RS16150	COG1289	transmembrane transporter activity
IT777_RS16155	COG3070	regulator of competence-specific genes
IT777_RS16180	COG1067	ATP-dependent peptidase activity
IT777_RS16190	COG3130	regulation of translation
IT777_RS16195	COG3009	Protein conserved in bacteria
IT777_RS16200	COG3008	intermembrane lipid transfer
IT777_RS16200	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IT777_RS16205	COG2995	paraquat-inducible protein a
IT777_RS16210	COG0488	(ABC) transporter
IT777_RS16220	COG0633	Ferredoxin
IT777_RS16220	COG3217	Mosc domain protein beta barrel domain protein
IT777_RS16235	COG0431	NADPH-dependent FMN reductase
IT777_RS16240	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IT777_RS16245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IT777_RS16250	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IT777_RS16260	COG0308	aminopeptidase N
IT777_RS16270	COG1473	amidohydrolase
IT777_RS16280	COG0814	amino acid
IT777_RS16300	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IT777_RS16305	COG1448	Aminotransferase
IT777_RS16310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IT777_RS16315	COG3108	Peptidase M15
IT777_RS16320	COG2989	Protein conserved in bacteria
IT777_RS16330	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
IT777_RS16340	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IT777_RS16345	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IT777_RS16350	COG3173	Aminoglycoside phosphotransferase
IT777_RS16365	COG3214	Protein conserved in bacteria
IT777_RS16380	COG0658	competence protein
IT777_RS16380	COG2333	competence protein COMEC
IT777_RS16390	COG0539	negative regulation of cytoplasmic translation
IT777_RS16400	COG0501	Belongs to the peptidase M48B family
IT777_RS16415	COG2323	membrane
IT777_RS16420	COG1944	ATP diphosphatase activity
IT777_RS16425	COG2116	formate transmembrane transporter activity
IT777_RS16430	COG1882	Formate acetyltransferase
IT777_RS16435	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IT777_RS16440	COG0477	Major facilitator Superfamily
IT777_RS16445	COG3302	dmso reductase anchor subunit
IT777_RS16450	COG0437	4 iron, 4 sulfur cluster binding
IT777_RS16455	COG0243	molybdopterin cofactor binding
IT777_RS16465	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IT777_RS16475	COG1674	ftsk spoiiie
IT777_RS16475	COG1178	ABC-type Fe3 transport system permease component
IT777_RS16485	COG0492	ferredoxin-NADP+ reductase activity
IT777_RS16490	COG4988	ABC transporter
IT777_RS16495	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IT777_RS16510	COG0542	response to heat
IT777_RS16520	COG1278	Cold shock
IT777_RS16530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IT777_RS16535	COG3593	DNA synthesis involved in DNA repair
IT777_RS16545	COG2431	L-lysine efflux transmembrane transporter activity
IT777_RS16555	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IT777_RS16565	COG0028	Belongs to the TPP enzyme family
IT777_RS16570	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
IT777_RS16575	COG0702	epimerase
IT777_RS16580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IT777_RS16585	COG3023	N-Acetylmuramoyl-L-alanine amidase
IT777_RS16590	COG2203	Gaf domain
IT777_RS16590	COG5001	Diguanylate cyclase
IT777_RS16590	COG4251	negative regulation of phosphorylation
IT777_RS16590	COG3706	GGDEF domain
IT777_RS16605	COG1126	abc transporter atp-binding protein
IT777_RS16610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IT777_RS16615	COG4215	(ABC) transporter
IT777_RS16620	COG4160	amino acid transport
IT777_RS16625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IT777_RS16630	COG5002	protein histidine kinase activity
IT777_RS16635	COG0745	RESPONSE REGULATOR receiver
IT777_RS16640	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IT777_RS16650	COG1177	transmembrane transport
IT777_RS16655	COG1176	ABC-type spermidine putrescine transport system, permease component I
IT777_RS16660	COG3842	ATPase activity
IT777_RS16665	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IT777_RS16680	COG0778	Nitroreductase
IT777_RS16705	COG3226	Transcriptional regulator
IT777_RS16710	COG0738	Major facilitator superfamily
IT777_RS16715	COG0561	phosphatase activity
IT777_RS16720	COG2814	Major facilitator Superfamily
IT777_RS16725	COG0671	phosphoesterase, PA-phosphatase related
IT777_RS16730	COG1349	DNA-binding transcription factor activity
IT777_RS16735	COG1686	Belongs to the peptidase S11 family
IT777_RS16740	COG0625	glutathione transferase activity
IT777_RS16745	COG2133	pyrroloquinoline quinone binding
IT777_RS16855	COG0747	negative chemotaxis
IT777_RS16865	COG1446	asparaginase
IT777_RS16870	COG0303	'Molybdopterin
IT777_RS16875	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IT777_RS16880	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IT777_RS16885	COG1882	Formate acetyltransferase
IT777_RS16890	COG0561	phosphatase activity
IT777_RS16900	COG1609	Transcriptional regulator
IT777_RS16905	COG2271	Major facilitator Superfamily
IT777_RS16915	COG0488	(ABC) transporter
IT777_RS16925	COG1376	ErfK ybiS ycfS ynhG family protein
IT777_RS16930	COG2188	Transcriptional regulator
IT777_RS16935	COG2723	6-phospho-beta-galactosidase activity
IT777_RS16940	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IT777_RS16945	COG1321	iron dependent repressor
IT777_RS16955	COG2194	sulfuric ester hydrolase activity
IT777_RS16960	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IT777_RS16975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IT777_RS16980	COG0765	amino acid transport
IT777_RS16985	COG1126	abc transporter atp-binding protein
IT777_RS16990	COG0668	transmembrane transport
IT777_RS17000	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IT777_RS17010	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IT777_RS17020	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IT777_RS17025	COG1199	ATP-dependent helicase activity
IT777_RS17030	COG0513	Belongs to the DEAD box helicase family
IT777_RS17035	COG3958	Transketolase
IT777_RS17040	COG3959	Transketolase, thiamine diphosphate binding domain
IT777_RS17045	COG1028	Short-chain dehydrogenase reductase Sdr
IT777_RS17050	COG2271	Major facilitator Superfamily
IT777_RS17060	COG0583	DNA-binding transcription factor activity
IT777_RS17065	COG1309	transcriptional regulator
IT777_RS17070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IT777_RS17075	COG1131	(ABC) transporter
IT777_RS17080	COG0842	Transport permease protein
IT777_RS17085	COG0842	Transport permease protein
IT777_RS17095	COG3568	Endonuclease Exonuclease Phosphatase
IT777_RS17100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IT777_RS17105	COG0392	lysyltransferase activity
IT777_RS17110	COG0670	Belongs to the BI1 family
IT777_RS17115	COG0314	molybdopterin synthase activity
IT777_RS17120	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IT777_RS17130	COG0521	Mo-molybdopterin cofactor biosynthetic process
IT777_RS17150	COG0745	RESPONSE REGULATOR receiver
IT777_RS17155	COG0642	Histidine kinase
IT777_RS17180	COG2226	methyltransferase
IT777_RS17195	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IT777_RS17200	COG1881	PFAM PEBP family protein
IT777_RS17240	COG4677	pectinesterase activity
IT777_RS17250	COG0589	response to stress
IT777_RS17255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IT777_RS17285	COG0789	Transcriptional regulator
IT777_RS17290	COG2200	EAL domain
IT777_RS17315	COG0561	phosphatase activity
IT777_RS17325	COG4149	molybdate abc transporter
IT777_RS17330	COG0725	ABC transporter, periplasmic molybdate-binding protein
IT777_RS17340	COG3585	molybdate ion transport
IT777_RS17340	COG2005	Transcriptional regulator
IT777_RS17345	COG1119	ATPase activity
IT777_RS17355	COG1085	galactose-1-phosphate uridylyltransferase
IT777_RS17365	COG2017	converts alpha-aldose to the beta-anomer
IT777_RS17375	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IT777_RS17390	COG3201	nicotinamide mononucleotide transporter
IT777_RS17395	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IT777_RS17455	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
IT777_RS17460	COG2885	chlorophyll binding
IT777_RS17470	COG3064	Membrane
IT777_RS17470	COG3064	Membrane
IT777_RS17475	COG0848	biopolymer transport protein
IT777_RS17480	COG0811	peptide transport
IT777_RS17485	COG0824	Thioesterase
IT777_RS17490	COG3790	cyd operon protein YbgE
IT777_RS17495	COG4890	Cyd operon protein YbgT
IT777_RS17500	COG1294	oxidase, subunit
IT777_RS17505	COG1271	oxidase subunit
IT777_RS17510	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IT777_RS17520	COG0508	dehydrogenase complex catalyzes the overall conversion of
IT777_RS17525	COG0567	Dehydrogenase, E1 component
IT777_RS17530	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IT777_RS17535	COG1053	succinate dehydrogenase
IT777_RS17540	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IT777_RS17545	COG2009	succinate dehydrogenase
IT777_RS17550	COG0372	Belongs to the citrate synthase family
IT777_RS17570	COG1984	allophanate hydrolase subunit 2
IT777_RS17575	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IT777_RS17590	COG0415	Belongs to the DNA photolyase family
IT777_RS17620	COG2205	protein histidine kinase activity
IT777_RS17625	COG0745	RESPONSE REGULATOR receiver
IT777_RS17635	COG0033	Phosphoglucomutase
IT777_RS17645	COG0596	Alpha beta hydrolase
IT777_RS17660	COG0735	belongs to the Fur family
IT777_RS17665	COG0583	DNA-binding transcription factor activity
IT777_RS17670	COG1053	succinate dehydrogenase
IT777_RS17715	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IT777_RS17720	COG1940	carbohydrate kinase activity
IT777_RS17720	COG1846	Transcriptional regulator
IT777_RS17725	COG0647	UMP catabolic process
IT777_RS17730	COG0367	asparagine synthase
IT777_RS17770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IT777_RS17780	COG1702	phosphate starvation-inducible protein PhoH
IT777_RS17805	COG0765	amino acid transport
IT777_RS17810	COG0765	amino acid transport
IT777_RS17815	COG1126	abc transporter atp-binding protein
IT777_RS17820	COG2831	hemolysin activation secretion protein
IT777_RS17830	COG2888	peptidyl-tyrosine sulfation
IT777_RS17845	COG1466	dna polymerase III delta subunit
IT777_RS17860	COG0799	negative regulation of ribosome biogenesis
IT777_RS17870	COG0768	penicillin binding
IT777_RS17875	COG0772	Belongs to the SEDS family
IT777_RS17880	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IT777_RS17885	COG1686	Belongs to the peptidase S11 family
IT777_RS17900	COG0583	DNA-binding transcription factor activity
IT777_RS17910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IT777_RS17915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IT777_RS17935	COG3069	C4-dicarboxylate transmembrane transporter activity
IT777_RS17940	COG3719	Belongs to the RNase T2 family
IT777_RS17945	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IT777_RS17965	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IT777_RS17970	COG0583	DNA-binding transcription factor activity
IT777_RS17975	COG3969	phosphoadenosine phosphosulfate
IT777_RS17980	COG1475	DNA binding
IT777_RS17985	COG0436	Aminotransferase
IT777_RS18010	COG1129	ABC transporter
IT777_RS18015	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT777_RS18020	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT777_RS18030	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IT777_RS18045	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IT777_RS18055	COG0402	S-adenosylhomocysteine deaminase activity
IT777_RS18060	COG1609	Transcriptional regulator
IT777_RS18065	COG0483	inositol monophosphate 1-phosphatase activity
IT777_RS18100	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT777_RS18105	COG1129	ABC transporter
IT777_RS18110	COG0371	Dehydrogenase
IT777_RS18125	COG2879	small protein
IT777_RS18130	COG1966	Carbon starvation protein
IT777_RS18140	COG1028	Short-chain dehydrogenase reductase Sdr
IT777_RS18145	COG3433	isochorismatase activity
IT777_RS18145	COG1535	isochorismatase
IT777_RS18150	COG1021	2,3-dihydroxybenzoate-AMP ligase
IT777_RS18155	COG1169	isochorismate synthase
IT777_RS18160	COG4592	Periplasmic binding protein
IT777_RS18170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IT777_RS18175	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IT777_RS18180	COG1120	ATPase activity
IT777_RS18185	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IT777_RS18185	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
IT777_RS18190	COG3251	PFAM MbtH domain protein
IT777_RS18195	COG2382	esterase
IT777_RS18200	COG4771	TonB-dependent receptor
IT777_RS18210	COG1879	ABC-type sugar transport system periplasmic component
IT777_RS18220	COG1129	ABC transporter
IT777_RS18225	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT777_RS18230	COG5464	transposase or invertase
IT777_RS18235	COG2390	Transcriptional regulator
IT777_RS18240	COG3959	Transketolase, thiamine diphosphate binding domain
IT777_RS18245	COG3958	Transketolase
IT777_RS18255	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IT777_RS18265	COG0583	DNA-binding transcription factor activity
IT777_RS18270	COG0668	transmembrane transport
IT777_RS18280	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IT777_RS18305	COG0747	negative chemotaxis
IT777_RS18310	COG0601	transmembrane transport
IT777_RS18315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IT777_RS18320	COG0444	Belongs to the ABC transporter superfamily
IT777_RS18325	COG4608	Belongs to the ABC transporter superfamily
IT777_RS18330	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IT777_RS18335	COG4221	oxidoreductase activity
IT777_RS18345	COG4215	(ABC) transporter
IT777_RS18350	COG0765	amino acid transport
IT777_RS18355	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IT777_RS18370	COG0697	spore germination
IT777_RS18385	COG4608	Belongs to the ABC transporter superfamily
IT777_RS18390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IT777_RS18410	COG3698	Phosphodiester glycosidase
IT777_RS18450	COG2315	Protein conserved in bacteria
IT777_RS18455	COG0778	Nitroreductase
IT777_RS18465	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IT777_RS18475	COG3716	PTS system mannose fructose sorbose family IID component
IT777_RS18480	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IT777_RS18485	COG2222	sugar isomerase
IT777_RS18505	COG0477	Major facilitator Superfamily
IT777_RS18510	COG0668	transmembrane transport
IT777_RS18515	COG1609	Transcriptional regulator
IT777_RS18535	COG2211	Major facilitator Superfamily
IT777_RS18540	COG1113	amino acid transport
IT777_RS18555	COG1012	belongs to the aldehyde dehydrogenase family
IT777_RS18560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IT777_RS18570	COG0531	amino acid
IT777_RS18615	COG0667	Aldo Keto reductase
IT777_RS18625	COG1473	amidohydrolase
IT777_RS18650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IT777_RS18655	COG1120	ATPase activity
IT777_RS18660	COG1566	PFAM secretion protein HlyD family protein
IT777_RS18705	COG4211	Belongs to the binding-protein-dependent transport system permease family
IT777_RS18710	COG1129	ABC transporter
IT777_RS18725	COG0673	inositol 2-dehydrogenase activity
IT777_RS18755	COG3104	oligopeptide transport
IT777_RS18760	COG1982	Orn Lys Arg decarboxylase major
IT777_RS18765	COG0531	amino acid
IT777_RS18770	COG3710	Transcriptional regulator
IT777_RS18780	COG1560	Kdo2-lipid A biosynthetic process
IT777_RS18795	COG3188	usher protein
IT777_RS18800	COG3121	Chaperone
IT777_RS18805	COG3539	Fimbrial protein
IT777_RS18855	COG2501	S4 domain
IT777_RS18865	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IT777_RS18880	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IT777_RS18885	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IT777_RS18905	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IT777_RS18910	COG4181	ATPase activity
IT777_RS18915	COG2755	lipolytic protein G-D-S-L family
IT777_RS18920	COG0300	oxidoreductase activity
IT777_RS18925	COG3118	belongs to the thioredoxin family
IT777_RS18930	COG0390	transport system, permease component
IT777_RS18935	COG4619	ABC transporter
IT777_RS18940	COG0330	HflC and HflK could
IT777_RS18945	COG1585	Membrane protein implicated in regulation of membrane protease activity
IT777_RS18960	COG3735	TraB family
IT777_RS18965	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IT777_RS18975	COG2223	nitrite transmembrane transporter activity
IT777_RS18980	COG4651	solute:proton antiporter activity
IT777_RS18980	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IT777_RS18985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IT777_RS19025	COG2832	Protein of unknown function (DUF454)
IT777_RS19030	COG3923	Primosomal replication protein n
IT777_RS19040	COG5464	transposase or invertase
IT777_RS19045	COG3264	Mechanosensitive ion channel
IT777_RS19045	COG1196	nuclear chromosome segregation
IT777_RS19050	COG1309	transcriptional regulator
IT777_RS19055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IT777_RS19060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IT777_RS19075	COG0110	maltose O-acetyltransferase activity
IT777_RS19125	COG1874	Beta-galactosidase
IT777_RS19130	COG3867	Arabinogalactan endo-beta-1,4-galactanase
IT777_RS19135	COG3833	ABC-type maltose transport systems, permease component
IT777_RS19140	COG1175	transmembrane transport
IT777_RS19145	COG2182	Extracellular solute-binding protein
IT777_RS19155	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IT777_RS19170	COG2364	Membrane
IT777_RS19200	COG3695	enzyme binding
IT777_RS19205	COG3126	Type III secretion system lipoprotein chaperone (YscW)
IT777_RS19210	COG1946	Acyl-CoA thioesterase
IT777_RS19215	COG0004	ammonium transporteR
IT777_RS19220	COG0347	Belongs to the P(II) protein family
IT777_RS19225	COG1132	(ABC) transporter
IT777_RS19230	COG1132	(ABC) transporter
IT777_RS19235	COG1522	sequence-specific DNA binding
IT777_RS19250	COG4533	DNA binding
IT777_RS19260	COG0824	Thioesterase
IT777_RS19265	COG1555	photosystem II stabilization
IT777_RS19270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IT777_RS19275	COG0776	regulation of translation
IT777_RS19280	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IT777_RS19300	COG0271	Belongs to the BolA IbaG family
IT777_RS19305	COG3056	Lipoprotein
IT777_RS19310	COG2223	nitrite transmembrane transporter activity
IT777_RS19315	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IT777_RS19320	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IT777_RS19325	COG1845	cytochrome c oxidase, subunit III
IT777_RS19330	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IT777_RS19345	COG1414	Transcriptional regulator
IT777_RS19355	COG1053	succinate dehydrogenase
IT777_RS19365	COG1053	succinate dehydrogenase
IT777_RS19380	COG0673	inositol 2-dehydrogenase activity
IT777_RS19385	COG2814	Major facilitator Superfamily
IT777_RS19395	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IT777_RS19420	COG0142	geranyltranstransferase activity
IT777_RS19430	COG0667	Aldo Keto reductase
IT777_RS19435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IT777_RS19440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IT777_RS19455	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IT777_RS19455	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IT777_RS19465	COG4238	major outer membrane lipoprotein
IT777_RS19485	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IT777_RS19490	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IT777_RS19495	COG1862	Preprotein translocase
IT777_RS19520	COG0450	alkyl hydroperoxide reductase
IT777_RS19530	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IT777_RS19545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IT777_RS19555	COG1228	amidohydrolase
IT777_RS19565	COG1335	isochorismatase
IT777_RS19570	COG0583	DNA-binding transcription factor activity
IT777_RS19575	COG0366	Alpha amylase catalytic
IT777_RS19600	COG0420	3'-5' exonuclease activity
IT777_RS19605	COG0419	ATPase involved in DNA repair
IT777_RS19610	COG1940	carbohydrate kinase activity
IT777_RS19625	COG4126	flavin adenine dinucleotide binding
IT777_RS19635	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IT777_RS19640	COG3416	Protein conserved in bacteria
IT777_RS19650	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IT777_RS19660	COG1785	Belongs to the alkaline phosphatase family
IT777_RS19700	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
IT777_RS19705	COG1335	isochorismatase
IT777_RS19710	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IT777_RS19715	COG0113	porphobilinogen synthase activity
IT777_RS19720	COG1943	Transposase
IT777_RS19730	COG2175	clavaminate synthase activity
IT777_RS19735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IT777_RS19740	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IT777_RS19745	COG4521	taurine ABC transporter
IT777_RS19750	COG2040	homocysteine
IT777_RS19755	COG0833	amino acid
IT777_RS19765	COG0531	amino acid
IT777_RS19770	COG4303	Ethanolamine ammonia lyase large subunit
IT777_RS19775	COG4302	ethanolamine ammonia-lyase activity
IT777_RS19815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IT777_RS19825	COG0765	amino acid transport
IT777_RS19830	COG0765	amino acid transport
IT777_RS19845	COG3188	usher protein
IT777_RS19870	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
IT777_RS19880	COG3639	organic phosphonate transmembrane transporter activity
IT777_RS19895	COG0791	NLP P60 protein
IT777_RS19925	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IT777_RS19960	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IT777_RS19965	COG0022	dehydrogenase e1 component
IT777_RS19970	COG0508	dehydrogenase complex catalyzes the overall conversion of
IT777_RS19975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IT777_RS19995	COG1070	Carbohydrate kinase
IT777_RS20000	COG1028	Short-chain dehydrogenase reductase Sdr
IT777_RS20005	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IT777_RS20010	COG3775	system Galactitol-specific IIC component
IT777_RS20015	COG0625	glutathione transferase activity
IT777_RS20020	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
IT777_RS20035	COG0579	oxidoreductase
IT777_RS20040	COG1012	belongs to the aldehyde dehydrogenase family
IT777_RS20045	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IT777_RS20050	COG1113	amino acid transport
IT777_RS20055	COG1802	Transcriptional regulator
IT777_RS20075	COG2195	Cleaves the N-terminal amino acid of tripeptides
IT777_RS20080	COG0454	-acetyltransferase
IT777_RS20095	COG2991	Protein conserved in bacteria
IT777_RS20110	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IT777_RS20115	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IT777_RS20130	COG3034	peptidoglycan biosynthetic process
IT777_RS20135	COG0121	glutamine amidotransferase
IT777_RS20145	COG1960	acyl-CoA dehydrogenase activity
IT777_RS20150	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IT777_RS20165	COG0583	DNA-binding transcription factor activity
IT777_RS20185	COG2226	methyltransferase
IT777_RS20195	COG0741	lytic transglycosylase activity
IT777_RS20195	COG1388	LysM domain
IT777_RS20200	COG2226	methyltransferase
IT777_RS20210	COG2814	Major facilitator Superfamily
IT777_RS20215	COG0583	DNA-binding transcription factor activity
IT777_RS20220	COG0656	L-ascorbic acid biosynthetic process
IT777_RS20255	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IT777_RS20265	COG2011	ABC-type metal ion transport system permease component
IT777_RS20270	COG1464	Belongs to the NlpA lipoprotein family
IT777_RS20280	COG1720	tRNA m6t6A37 methyltransferase activity
IT777_RS20290	COG0791	NLP P60 protein
IT777_RS20295	COG3015	lipoprotein NlpE involved in copper resistance
IT777_RS20300	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IT777_RS20315	COG4568	rho-dependent transcription termination
IT777_RS20325	COG0346	lactoylglutathione lyase activity
IT777_RS20330	COG1982	Orn Lys Arg decarboxylase major
IT777_RS20340	COG0587	DNA-directed DNA polymerase activity
IT777_RS20370	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
IT777_RS20380	COG0750	zinc metalloprotease
IT777_RS20385	COG0575	Belongs to the CDS family
IT777_RS20420	COG0024	Methionine aminopeptidase
IT777_RS20425	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IT777_RS20440	COG3835	regulator
IT777_RS20445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IT777_RS20465	COG2860	membrane
IT777_RS20485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IT777_RS20490	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IT777_RS20495	COG1120	ATPase activity
IT777_RS20500	COG4774	siderophore transport
IT777_RS20505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IT777_RS20595	COG1643	Atp-dependent helicase
IT777_RS20600	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
IT777_RS20620	COG0617	tRNA 3'-terminal CCA addition
IT777_RS20625	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IT777_RS20645	COG0726	polysaccharide deacetylase
IT777_RS20650	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IT777_RS20655	COG0842	Transport permease protein
IT777_RS20660	COG1131	(ABC) transporter
IT777_RS20665	COG0288	reversible hydration of carbon dioxide
IT777_RS20680	COG4993	Dehydrogenase
IT777_RS20685	COG2132	Multicopper oxidase
IT777_RS20725	COG3064	Membrane
IT777_RS20740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IT777_RS20745	COG0508	dehydrogenase complex catalyzes the overall conversion of
IT777_RS20750	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IT777_RS20755	COG2186	Transcriptional regulator
IT777_RS20760	COG1113	amino acid transport
IT777_RS20765	COG2211	Major facilitator Superfamily
IT777_RS20770	COG3940	Belongs to the glycosyl hydrolase 43 family
IT777_RS20775	COG3725	Membrane protein required for beta-lactamase induction
IT777_RS20790	COG4969	Belongs to the N-Me-Phe pilin family
IT777_RS20795	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IT777_RS20800	COG1459	type II secretion system
IT777_RS20825	COG0494	nUDIX hydrolase
IT777_RS20845	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IT777_RS20850	COG0849	cell division
IT777_RS20875	COG0772	Belongs to the SEDS family
IT777_RS20890	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IT777_RS20900	COG0768	penicillin binding
IT777_RS20920	COG1609	Transcriptional regulator
IT777_RS20930	COG0028	Belongs to the TPP enzyme family
IT777_RS20970	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IT777_RS20975	COG0738	Major facilitator superfamily
IT777_RS20985	COG0583	DNA-binding transcription factor activity
IT777_RS20990	COG2271	Major facilitator Superfamily
IT777_RS20995	COG2814	Major facilitator Superfamily
IT777_RS21015	COG1178	ABC-type Fe3 transport system permease component
IT777_RS21025	COG0586	Pfam SNARE associated Golgi protein
IT777_RS21050	COG0417	DNA replication proofreading
IT777_RS21060	COG0564	pseudouridine synthase activity
IT777_RS21070	COG3493	citrate carrier protein
IT777_RS21085	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IT777_RS21090	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IT777_RS21100	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IT777_RS21145	COG0505	Belongs to the CarA family
IT777_RS21190	COG5016	pyruvate
IT777_RS21190	COG0511	ligase activity, forming carbon-carbon bonds
IT777_RS21225	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IT777_RS21230	COG0471	metal ion transport
IT777_RS21235	COG0471	metal ion transport
IT777_RS21240	COG2828	Protein conserved in bacteria
IT777_RS21245	COG0583	DNA-binding transcription factor activity
IT777_RS21260	COG1047	Peptidyl-prolyl cis-trans
IT777_RS21275	COG0196	riboflavin kinase activity
IT777_RS21285	COG0583	DNA-binding transcription factor activity
IT777_RS21300	COG0641	radical SAM
IT777_RS21305	COG3119	arylsulfatase activity
IT777_RS21330	COG4735	regulation of single-species biofilm formation
IT777_RS21335	COG1584	GPR1 FUN34 yaaH family protein
IT777_RS21340	COG0477	Major facilitator Superfamily
IT777_RS21345	COG0521	Mo-molybdopterin cofactor biosynthetic process
IT777_RS21350	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IT777_RS21355	COG1115	amino acid carrier protein
IT777_RS21365	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IT777_RS21375	COG0527	aspartate kinase activity
IT777_RS21375	COG0460	homoserine dehydrogenase
IT777_RS21385	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
IT777_RS21395	COG0745	RESPONSE REGULATOR receiver
IT777_RS21400	COG4452	Inner membrane protein CreD
IT777_RS21405	COG2205	protein histidine kinase activity
IT777_RS21410	COG0745	RESPONSE REGULATOR receiver
IT777_RS21415	COG3045	CreA protein
IT777_RS21420	COG3708	Transcriptional regulator
IT777_RS21420	COG2207	Transcriptional regulator
IT777_RS21440	COG0741	lytic transglycosylase activity
IT777_RS21445	COG0488	(ABC) transporter
IT777_RS21455	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IT777_RS21460	COG0560	Phosphoserine phosphatase
IT777_RS21465	COG3726	membrane protein affecting hemolysin expression
IT777_RS21495	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IT777_RS21500	COG0084	hydrolase, TatD family'
IT777_RS21505	COG4667	esterase of the alpha-beta hydrolase superfamily
IT777_RS21515	COG2823	Periplasmic or secreted lipoprotein
IT777_RS21525	COG1011	Hydrolase
IT777_RS21530	COG0456	acetyltransferase
IT777_RS21535	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
IT777_RS21570	COG3706	GGDEF domain
IT777_RS21575	COG4114	ferric iron reductase
IT777_RS21580	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IT777_RS21580	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IT777_RS21585	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IT777_RS21590	COG2197	response regulator
IT777_RS21595	COG2197	response regulator
IT777_RS21610	COG2966	Psort location CytoplasmicMembrane, score
IT777_RS21625	COG1484	DNA-dependent DNA replication
IT777_RS21640	COG5464	transposase or invertase
IT777_RS21650	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IT777_RS21655	COG3716	PTS system mannose fructose sorbose family IID component
IT777_RS21660	COG3715	PTS system
IT777_RS21675	COG3933	PFAM sigma-54 factor interaction domain-containing protein
IT777_RS21675	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IT777_RS21680	COG0456	acetyltransferase
IT777_RS21690	COG1737	Transcriptional regulator
IT777_RS21695	COG0800	Aldolase
IT777_RS21700	COG3734	2-keto-3-deoxy-galactonokinase
IT777_RS21705	COG4145	pantothenate transmembrane transporter activity
IT777_RS21715	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IT777_RS21735	COG1846	Transcriptional regulator
IT777_RS21745	COG0179	Fumarylacetoacetate (FAA) hydrolase
IT777_RS21755	COG1012	belongs to the aldehyde dehydrogenase family
IT777_RS21760	COG3384	dioxygenase
IT777_RS21770	COG3971	2-oxopent-4-enoate hydratase activity
IT777_RS21790	COG2368	4-hydroxyphenylacetate
IT777_RS21795	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IT777_RS21800	COG1966	Carbon starvation protein
IT777_RS21805	COG2879	small protein
IT777_RS21810	COG0523	cobalamin synthesis protein
IT777_RS21825	COG1012	belongs to the aldehyde dehydrogenase family
IT777_RS21835	COG2207	Transcriptional regulator
IT777_RS21835	COG1917	Cupin 2, conserved barrel domain protein
IT777_RS21845	COG2733	membrane
IT777_RS21850	COG2814	Major facilitator Superfamily
IT777_RS21860	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
IT777_RS21865	COG1924	4 iron, 4 sulfur cluster binding
IT777_RS21880	COG1566	PFAM secretion protein HlyD family protein
IT777_RS21890	COG5457	Domain of unknown function (DUF1127)
IT777_RS21895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IT777_RS21905	COG0583	DNA-binding transcription factor activity
IT777_RS21910	COG2249	NAD(P)H dehydrogenase (quinone) activity
IT777_RS21920	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT777_RS21925	COG1129	ABC transporter
IT777_RS21930	COG1879	ABC-type sugar transport system periplasmic component
IT777_RS21940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IT777_RS21945	COG0842	Transport permease protein
IT777_RS21945	COG1129	ABC transporter
IT777_RS21950	COG0842	Transport permease protein
IT777_RS21985	COG2850	peptidyl-arginine hydroxylation
IT777_RS21990	COG5002	protein histidine kinase activity
IT777_RS21995	COG0745	RESPONSE REGULATOR receiver
IT777_RS22000	COG1538	Outer membrane efflux protein
IT777_RS22005	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IT777_RS22010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IT777_RS22015	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IT777_RS22025	COG3040	lipid binding
IT777_RS22030	COG0789	Transcriptional regulator
IT777_RS22040	COG0300	oxidoreductase activity
IT777_RS22055	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IT777_RS22075	COG3272	Protein of unknown function (DUF1722)
IT777_RS22080	COG4580	involved in the transport of maltose and maltodextrins
IT777_RS22090	COG2211	Major facilitator Superfamily
IT777_RS22095	COG3507	Belongs to the glycosyl hydrolase 43 family
IT777_RS22145	COG1204	response to ionizing radiation
IT777_RS22245	COG0582	viral genome integration into host DNA
IT777_RS22255	COG0288	reversible hydration of carbon dioxide
IT777_RS22260	COG0659	secondary active sulfate transmembrane transporter activity
IT777_RS22265	COG1064	alcohol dehydrogenase
IT777_RS22270	COG1175	transmembrane transport
IT777_RS22275	COG0395	ABC-type sugar transport system, permease component
IT777_RS22280	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IT777_RS22285	COG3842	ATPase activity
IT777_RS22300	COG1082	Xylose isomerase domain protein TIM barrel
IT777_RS22310	COG3962	Belongs to the TPP enzyme family
IT777_RS22315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IT777_RS22320	COG0837	glucose binding
IT777_RS22320	COG1737	Transcriptional regulator
IT777_RS22325	COG3718	enzyme involved in inositol metabolism
IT777_RS22340	COG0433	COG0433 Predicted ATPase
IT777_RS22345	COG0795	lipopolysaccharide-transporting ATPase activity
IT777_RS22350	COG0795	lipopolysaccharide-transporting ATPase activity
IT777_RS22360	COG2927	DNA polymerase III (CHI subunit)
IT777_RS22365	COG0525	valine-tRNA ligase activity
IT777_RS22370	COG4269	membrane
IT777_RS22385	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
IT777_RS22395	COG2731	YhcH YjgK YiaL family protein
IT777_RS22430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IT777_RS22430	COG1263	PTS System
IT777_RS22435	COG0366	Alpha amylase catalytic
IT777_RS22445	COG0602	queuosine metabolic process
IT777_RS22450	COG2026	Addiction module toxin, RelE StbE family
IT777_RS22455	COG3077	Addiction module antitoxin, RelB DinJ family
IT777_RS22460	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IT777_RS22460	COG3711	transcriptional antiterminator
IT777_RS22465	COG2706	6-phosphogluconolactonase activity
IT777_RS22480	COG3964	amidohydrolase
IT777_RS22515	COG0312	modulator of DNA gyrase
IT777_RS22535	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IT777_RS22545	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT777_RS22550	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT777_RS22555	COG1129	ABC transporter
IT777_RS22560	COG1879	ABC-type sugar transport system periplasmic component
IT777_RS22575	COG2105	PFAM AIG2 family protein
IT777_RS22580	COG2911	Protein conserved in bacteria
IT777_RS22585	COG0729	surface antigen
IT777_RS22595	COG1253	flavin adenine dinucleotide binding
IT777_RS22610	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
IT777_RS22625	COG1733	regulation of RNA biosynthetic process
IT777_RS22630	COG0702	epimerase
IT777_RS22640	COG0697	spore germination
IT777_RS22650	COG1113	amino acid transport
IT777_RS22655	COG0545	Peptidyl-prolyl cis-trans isomerase
IT777_RS22660	COG3061	Opacity-associated protein A
IT777_RS22670	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IT777_RS22675	COG2965	DNA replication, synthesis of RNA primer
IT777_RS22700	COG1073	alpha beta
IT777_RS22705	COG3650	response to hydrogen peroxide
IT777_RS22715	COG1960	acyl-CoA dehydrogenase activity
IT777_RS22720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IT777_RS22725	COG0557	exoribonuclease II activity
IT777_RS22740	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
IT777_RS22750	COG0330	HflC and HflK could
IT777_RS22755	COG0330	HflC and HflK could
IT777_RS22760	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IT777_RS22780	COG0860	N-Acetylmuramoyl-L-alanine amidase
IT777_RS22785	COG0802	atpase or kinase
IT777_RS22790	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IT777_RS22790	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IT777_RS22795	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IT777_RS22815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IT777_RS22835	COG3264	Mechanosensitive ion channel
IT777_RS22835	COG1511	domain protein
IT777_RS22850	COG1053	succinate dehydrogenase
IT777_RS22855	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IT777_RS22875	COG2076	Multidrug Resistance protein
IT777_RS22885	COG5510	response to toxic substance
IT777_RS22895	COG1509	lysine 2,3-aminomutase activity
IT777_RS22960	COG0531	amino acid
IT777_RS22965	COG3030	protein affecting phage T7 exclusion by the F plasmid
IT777_RS22970	COG1027	Aspartate ammonia-lyase
IT777_RS22975	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IT777_RS22990	COG1309	transcriptional regulator
IT777_RS23015	COG0457	Tetratricopeptide repeat
IT777_RS23020	COG1649	PFAM Uncharacterised BCR, COG1649
IT777_RS23020	COG0726	polysaccharide deacetylase
IT777_RS23025	COG1215	transferase activity, transferring glycosyl groups
IT777_RS23040	COG0861	Integral membrane protein TerC family
IT777_RS23075	COG1486	melibiose metabolic process
IT777_RS23080	COG2169	Transcriptional regulator
IT777_RS23090	COG2824	Alkylphosphonate utilization operon protein PhnA
IT777_RS23095	COG2764	glyoxalase bleomycin resistance protein dioxygenase
IT777_RS23100	COG2188	Transcriptional regulator
IT777_RS23105	COG3624	Phosphonate C-P lyase system protein PhnG
IT777_RS23110	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
IT777_RS23115	COG3626	phosphonate metabolism
IT777_RS23120	COG3627	carbon phosphorus lyase activity
IT777_RS23125	COG4107	phosphonate C-P lyase system protein PhnK
IT777_RS23130	COG4778	phosphonate C-P lyase system protein PhnL
IT777_RS23135	COG3454	Phosphonate metabolism
IT777_RS23145	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IT777_RS23155	COG0784	Response regulator, receiver
IT777_RS23155	COG4191	Histidine kinase
IT777_RS23160	COG1129	ABC transporter
IT777_RS23165	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT777_RS23190	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
IT777_RS23195	COG1301	dicarboxylic acid transport
IT777_RS23210	COG3162	membrane
IT777_RS23235	COG3121	Chaperone
IT777_RS23240	COG3539	Fimbrial protein
IT777_RS23245	COG1346	cytolysis
IT777_RS23250	COG1380	Effector of murein hydrolase LrgA
IT777_RS23255	COG0583	DNA-binding transcription factor activity
IT777_RS23260	COG0025	NhaP-type Na H and K H
IT777_RS23265	COG2252	PERMEase
IT777_RS23270	COG0625	glutathione transferase activity
IT777_RS23275	COG0789	Transcriptional regulator
IT777_RS23285	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IT777_RS23320	COG0741	lytic transglycosylase activity
IT777_RS23335	COG2315	Protein conserved in bacteria
IT777_RS23340	COG0432	Pfam Uncharacterised protein family UPF0047
IT777_RS23355	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IT777_RS23360	COG0305	Participates in initiation and elongation during chromosome replication
IT777_RS23375	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IT777_RS23385	COG0735	belongs to the Fur family
IT777_RS23390	COG3237	CsbD-like
IT777_RS23395	COG0534	Mate efflux family protein
IT777_RS23405	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IT777_RS23475	COG0251	oxidation-reduction process
IT777_RS23485	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IT777_RS23495	COG0527	aspartate kinase activity
IT777_RS23545	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IT777_RS23555	COG0456	acetyltransferase
IT777_RS23585	COG0151	Belongs to the GarS family
IT777_RS23595	COG4191	Histidine kinase
IT777_RS23600	COG3678	ATP-independent chaperone mediated protein folding
IT777_RS23635	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
IT777_RS23650	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IT777_RS23655	COG2104	thiamine diphosphate biosynthetic process
IT777_RS23665	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IT777_RS23670	COG3706	GGDEF domain
IT777_RS23680	COG1447	Phosphotransferase system cellobiose-specific component IIA
IT777_RS23685	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IT777_RS23720	COG0250	Participates in transcription elongation, termination and antitermination
IT777_RS23765	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IT777_RS23795	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
IT777_RS23805	COG1739	Uncharacterized protein family UPF0029
IT777_RS23845	COG0805	protein transport
IT777_RS23865	COG3165	ubiquinone biosynthetic process from chorismate
IT777_RS23895	COG0583	DNA-binding transcription factor activity
IT777_RS23900	COG0697	spore germination
IT777_RS23905	COG0561	phosphatase activity
IT777_RS23910	COG2267	carboxylic ester hydrolase activity
IT777_RS23915	COG1280	lysine exporter protein (LysE YggA)
IT777_RS23925	COG1280	lysine exporter protein (LysE YggA)
IT777_RS23955	COG0210	DNA helicase
IT777_RS23960	COG1011	Hydrolase
IT777_RS23990	COG3072	Adenylate cyclase
IT777_RS24005	COG2959	enzyme of heme biosynthesis
IT777_RS24010	COG3071	HemY protein
IT777_RS24055	COG2244	polysaccharide biosynthetic process
IT777_RS24060	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IT777_RS24065	COG0456	acetyltransferase
IT777_RS24070	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IT777_RS24075	COG1088	dTDP-glucose 4,6-dehydratase activity
IT777_RS24080	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IT777_RS24085	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IT777_RS24095	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IT777_RS24100	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IT777_RS24105	COG3118	belongs to the thioredoxin family
IT777_RS24125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IT777_RS24130	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IT777_RS24140	COG0583	DNA-binding transcription factor activity
IT777_RS24145	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IT777_RS24160	COG3978	acetolactate synthase activity
IT777_RS24185	COG3085	chromosome segregation
IT777_RS24260	COG0583	DNA-binding transcription factor activity
IT777_RS24275	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IT777_RS24290	COG3443	Belongs to the bacterial solute-binding protein 9 family
IT777_RS24295	COG2207	Transcriptional regulator
IT777_RS24305	COG0371	Dehydrogenase
IT777_RS24315	COG0583	DNA-binding transcription factor activity
IT777_RS24320	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IT777_RS24325	COG0460	homoserine dehydrogenase
IT777_RS24325	COG0527	aspartate kinase activity
IT777_RS24330	COG0626	cystathionine gamma-synthase activity
IT777_RS24345	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IT777_RS24350	COG1609	Transcriptional regulator
IT777_RS24355	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IT777_RS24370	COG1575	Belongs to the MenA family. Type 1 subfamily
IT777_RS24390	COG3678	ATP-independent chaperone mediated protein folding
IT777_RS24395	COG0745	RESPONSE REGULATOR receiver
IT777_RS24400	COG2205	protein histidine kinase activity
IT777_RS24405	COG2258	MOSC domain
IT777_RS24410	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IT777_RS24450	COG1129	ABC transporter
IT777_RS24455	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT777_RS24465	COG1454	alcohol dehydrogenase
IT777_RS24475	COG0110	maltose O-acetyltransferase activity
IT777_RS24480	COG2211	Major facilitator Superfamily
IT777_RS24540	COG0205	6-phosphofructokinase activity
IT777_RS24560	COG0437	4 iron, 4 sulfur cluster binding
IT777_RS24565	COG2864	formate dehydrogenase
IT777_RS24575	COG0657	acetylesterase activity
IT777_RS24580	COG0456	acetyltransferase
IT777_RS24595	COG1011	Hydrolase
IT777_RS24610	COG3852	Histidine kinase
IT777_RS24640	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IT777_RS24640	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IT777_RS24645	COG0204	Acyl-transferase
IT777_RS24655	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IT777_RS24660	COG3084	Protein conserved in bacteria
IT777_RS24670	COG1763	Mo-molybdopterin cofactor biosynthetic process
IT777_RS24695	COG2186	Transcriptional regulator
IT777_RS24700	COG0477	Major facilitator Superfamily
IT777_RS24705	COG1609	Transcriptional regulator
IT777_RS24710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IT777_RS24720	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT777_RS24725	COG1129	ABC transporter
IT777_RS24755	COG1522	sequence-specific DNA binding
IT777_RS24760	COG0716	FMN binding
IT777_RS24775	COG3312	ion transport
IT777_RS24825	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IT777_RS24830	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IT777_RS24835	COG0573	inorganic phosphate transmembrane transporter activity
IT777_RS24840	COG0581	inorganic phosphate transmembrane transporter activity
IT777_RS24845	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IT777_RS24850	COG0704	Plays a role in the regulation of phosphate uptake
IT777_RS24860	COG2382	esterase
IT777_RS24865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IT777_RS24870	COG2252	PERMEase
IT777_RS24875	COG0431	NADPH-dependent FMN reductase
IT777_RS24880	COG2091	lysine biosynthetic process via aminoadipic acid
IT777_RS24910	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IT777_RS24940	COG2826	transposase and inactivated derivatives, IS30 family
IT777_RS24965	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IT777_RS24970	COG0625	glutathione transferase activity
IT777_RS25000	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IT777_RS25010	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IT777_RS25030	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IT777_RS25140	COG0789	Transcriptional regulator
IT777_RS25150	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IT777_RS25205	COG3344	reverse transcriptase
IT777_RS25355	COG0210	DNA helicase
IT777_RS25660	COG3039	Transposase
IT777_RS25675	COG0633	Ferredoxin
IT777_RS25985	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IT777_RS25995	COG0589	response to stress
IT777_RS26000	COG0659	secondary active sulfate transmembrane transporter activity
IT777_RS26050	COG1393	Belongs to the ArsC family
IT777_RS26055	COG0431	NADPH-dependent FMN reductase
IT777_RS26190	COG3385	transposase activity
IT777_RS26210	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IT777_RS26240	COG3039	Transposase
IT777_RS26260	COG0025	NhaP-type Na H and K H
IT777_RS26280	COG2916	Histone family protein nucleoid-structuring protein H-NS
IT777_RS26350	COG3039	Transposase
IT777_RS26390	COG3039	Transposase
IT777_RS26485	COG1660	Displays ATPase and GTPase activities
IT777_RS26500	COG3173	Aminoglycoside phosphotransferase
IT777_RS26525	COG1695	Transcriptional regulator
IT777_RS26540	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IT777_RS26555	COG1609	Transcriptional regulator
IT777_RS26560	COG2814	Major facilitator Superfamily
IT777_RS26565	COG1082	Xylose isomerase domain protein TIM barrel
IT777_RS26570	COG0673	inositol 2-dehydrogenase activity
IT777_RS26585	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IT777_RS26590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IT777_RS26595	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IT777_RS26685	COG4372	Transposase
IT777_RS26695	COG2963	transposase activity
IT777_RS26700	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IT777_RS26710	COG0789	Transcriptional regulator
IT777_RS26775	COG4372	Transposase
IT777_RS26780	COG3436	PFAM IS66 Orf2 family protein
IT777_RS26795	COG2390	Transcriptional regulator
IT777_RS26805	COG2376	Dihydroxyacetone kinase
IT777_RS26810	COG2814	Major facilitator Superfamily
IT777_RS26815	COG1063	alcohol dehydrogenase
IT777_RS26820	COG0698	ribose 5-phosphate isomerase
IT777_RS26825	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IT777_RS26830	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IT777_RS26840	COG1609	Transcriptional regulator
IT777_RS26850	COG0765	amino acid transport
IT777_RS26855	COG1126	abc transporter atp-binding protein
IT777_RS26860	COG0673	inositol 2-dehydrogenase activity
IT777_RS26865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IT777_RS26920	COG3344	reverse transcriptase
IT777_RS26990	COG5290	Psort location Cytoplasmic, score
IT777_RS27060	COG2198	Histidine kinase
IT777_RS27060	COG5002	protein histidine kinase activity
IT777_RS27060	COG0784	Response regulator, receiver
IT777_RS27085	COG0741	lytic transglycosylase activity
IT777_RS27155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IT777_RS27340	COG2003	Belongs to the UPF0758 family