locus-tag	class	description
ISA75_RS00015	COG1447	Phosphotransferase system cellobiose-specific component IIA
ISA75_RS00020	COG1940	carbohydrate kinase activity
ISA75_RS00035	COG1121	(ABC) transporter
ISA75_RS00045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISA75_RS00080	COG3720	iron ion transport
ISA75_RS00160	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISA75_RS00165	COG4942	peptidase
ISA75_RS00165	COG1388	LysM domain
ISA75_RS00225	COG2234	aminopeptidase activity
ISA75_RS00245	COG0720	synthase
ISA75_RS00250	COG0602	queuosine metabolic process
ISA75_RS00270	COG3956	TIGRFAM MazG family protein
ISA75_RS00275	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISA75_RS00285	COG2205	protein histidine kinase activity
ISA75_RS00285	COG3850	Histidine kinase
ISA75_RS00285	COG3437	response regulator, receiver
ISA75_RS00285	COG4999	Histidine kinase
ISA75_RS00290	COG1929	Belongs to the glycerate kinase type-1 family
ISA75_RS00295	COG4948	Mandelate Racemase Muconate Lactonizing
ISA75_RS00300	COG4948	Mandelate Racemase Muconate Lactonizing
ISA75_RS00305	COG2271	Major facilitator Superfamily
ISA75_RS00310	COG0716	FMN binding
ISA75_RS00315	COG0564	pseudouridine synthase activity
ISA75_RS00320	COG3098	single-species biofilm formation
ISA75_RS00335	COG1611	Belongs to the LOG family
ISA75_RS00340	COG0814	amino acid
ISA75_RS00345	COG1760	l-serine dehydratase
ISA75_RS00350	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISA75_RS00360	COG0477	Major facilitator Superfamily
ISA75_RS00365	COG1464	Belongs to the NlpA lipoprotein family
ISA75_RS00370	COG2011	ABC-type metal ion transport system permease component
ISA75_RS00375	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ISA75_RS00390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISA75_RS00410	COG1454	alcohol dehydrogenase
ISA75_RS00415	COG0235	Class ii aldolase
ISA75_RS00420	COG0738	Major facilitator superfamily
ISA75_RS00440	COG1349	DNA-binding transcription factor activity
ISA75_RS00450	COG2363	Small membrane protein
ISA75_RS00455	COG0583	DNA-binding transcription factor activity
ISA75_RS00465	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ISA75_RS00470	COG2166	iron-sulfur cluster assembly
ISA75_RS00475	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ISA75_RS00480	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ISA75_RS00645	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
ISA75_RS00675	COG1454	alcohol dehydrogenase
ISA75_RS00675	COG1012	belongs to the aldehyde dehydrogenase family
ISA75_RS00680	COG4656	Part of a membrane complex involved in electron transport
ISA75_RS00710	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ISA75_RS00715	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISA75_RS00720	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ISA75_RS00720	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ISA75_RS00735	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ISA75_RS00740	COG1074	ATP-dependent DNA helicase activity
ISA75_RS00745	COG1025	Belongs to the peptidase M16 family
ISA75_RS00750	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ISA75_RS00755	COG4967	type IV pilus modification protein PilV
ISA75_RS00765	COG4795	General secretion pathway protein
ISA75_RS00770	COG2165	general secretion pathway protein
ISA75_RS00805	COG0861	Integral membrane protein TerC family
ISA75_RS00815	COG0667	Aldo Keto reductase
ISA75_RS00835	COG1609	Transcriptional regulator
ISA75_RS00845	COG2186	Transcriptional regulator
ISA75_RS00850	COG2723	6-phospho-beta-galactosidase activity
ISA75_RS00855	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA75_RS00860	COG1609	Transcriptional regulator
ISA75_RS00870	COG0583	DNA-binding transcription factor activity
ISA75_RS00875	COG1794	racemase activity, acting on amino acids and derivatives
ISA75_RS00880	COG1917	Cupin 2, conserved barrel domain protein
ISA75_RS00885	COG1175	transmembrane transport
ISA75_RS00890	COG0395	ABC-type sugar transport system, permease component
ISA75_RS00895	COG3842	ATPase activity
ISA75_RS00930	COG2814	Major facilitator Superfamily
ISA75_RS00935	COG1028	Short-chain dehydrogenase reductase Sdr
ISA75_RS00940	COG0823	Involved in the tonB-independent uptake of proteins
ISA75_RS00950	COG0183	Belongs to the thiolase family
ISA75_RS00965	COG0814	amino acid
ISA75_RS00970	COG0667	Aldo Keto reductase
ISA75_RS01020	COG0697	spore germination
ISA75_RS01025	COG1846	Transcriptional regulator
ISA75_RS01030	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ISA75_RS01040	COG3188	usher protein
ISA75_RS01045	COG3121	Chaperone
ISA75_RS01065	COG0582	viral genome integration into host DNA
ISA75_RS01070	COG4974	Belongs to the 'phage' integrase family
ISA75_RS01080	COG3539	Fimbrial protein
ISA75_RS01085	COG3121	Chaperone
ISA75_RS01090	COG3188	usher protein
ISA75_RS01095	COG3539	Fimbrial protein
ISA75_RS01100	COG3539	Fimbrial protein
ISA75_RS01105	COG3539	Fimbrial protein
ISA75_RS01115	COG2388	GCN5-related N-acetyl-transferase
ISA75_RS01120	COG3592	Divergent 4Fe-4S mono-cluster
ISA75_RS01135	COG1289	transmembrane transporter activity
ISA75_RS01140	COG1538	Outer membrane efflux protein
ISA75_RS01155	COG1393	Belongs to the ArsC family
ISA75_RS01160	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ISA75_RS01195	COG2249	NAD(P)H dehydrogenase (quinone) activity
ISA75_RS01200	COG0667	Aldo Keto reductase
ISA75_RS01215	COG2814	Major facilitator Superfamily
ISA75_RS01225	COG4942	peptidase
ISA75_RS01245	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ISA75_RS01255	COG4974	Belongs to the 'phage' integrase family
ISA75_RS01260	COG0716	FMN binding
ISA75_RS01270	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ISA75_RS01280	COG1272	protein, Hemolysin III
ISA75_RS01290	COG1737	Transcriptional regulator
ISA75_RS01295	COG2723	6-phospho-beta-galactosidase activity
ISA75_RS01315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISA75_RS01320	COG1028	Short-chain dehydrogenase reductase Sdr
ISA75_RS01340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISA75_RS01345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISA75_RS01350	COG0006	proline dipeptidase activity
ISA75_RS01370	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ISA75_RS01380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISA75_RS01395	COG2968	Membrane
ISA75_RS01405	COG0668	transmembrane transport
ISA75_RS01410	COG0191	fructose-bisphosphate aldolase activity
ISA75_RS01425	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ISA75_RS01430	COG0501	Belongs to the peptidase M48B family
ISA75_RS01465	COG2814	Major facilitator Superfamily
ISA75_RS01475	COG2356	endonuclease I
ISA75_RS01480	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ISA75_RS01485	COG0189	ligase activity
ISA75_RS01505	COG2805	Type II/IV secretion system protein
ISA75_RS01510	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ISA75_RS01515	COG0762	integral membrane protein
ISA75_RS01530	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISA75_RS01540	COG3171	Protein conserved in bacteria
ISA75_RS01550	COG1194	a g-specific adenine glycosylase
ISA75_RS01565	COG2211	Major facilitator Superfamily
ISA75_RS01570	COG1982	Orn Lys Arg decarboxylase major
ISA75_RS01575	COG1811	Na channel or pump
ISA75_RS01590	COG0626	cystathionine gamma-synthase activity
ISA75_RS01620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISA75_RS01625	COG0754	glutathionylspermidine amidase activity
ISA75_RS01640	COG0625	glutathione transferase activity
ISA75_RS01660	COG0848	biopolymer transport protein
ISA75_RS01670	COG0626	cystathionine gamma-synthase activity
ISA75_RS01675	COG0586	Pfam SNARE associated Golgi protein
ISA75_RS01680	COG2207	Transcriptional regulator
ISA75_RS01685	COG1979	alcohol dehydrogenase
ISA75_RS01690	COG0656	L-ascorbic acid biosynthetic process
ISA75_RS01695	COG1032	radical SAM domain protein
ISA75_RS01700	COG2132	Multicopper oxidase
ISA75_RS01705	COG0204	Acyl-transferase
ISA75_RS01710	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ISA75_RS01715	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
ISA75_RS01720	COG3111	PFAM Bacterial OB fold (BOF) protein
ISA75_RS01730	COG0642	Histidine kinase
ISA75_RS01735	COG2249	NAD(P)H dehydrogenase (quinone) activity
ISA75_RS01740	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ISA75_RS01750	COG3150	esterase
ISA75_RS01755	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ISA75_RS01760	COG3151	Protein conserved in bacteria
ISA75_RS01765	COG0494	nUDIX hydrolase
ISA75_RS01780	COG0754	glutathionylspermidine amidase activity
ISA75_RS01785	COG3384	dioxygenase
ISA75_RS01800	COG2960	long-chain fatty acid transporting porin activity
ISA75_RS01825	COG3025	triphosphatase activity
ISA75_RS01830	COG4991	sh3 domain protein
ISA75_RS01845	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ISA75_RS01905	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ISA75_RS01910	COG0358	DNA primase activity
ISA75_RS01915	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISA75_RS01940	COG0426	domain, Protein
ISA75_RS01940	COG1773	rubredoxin
ISA75_RS01955	COG2197	response regulator
ISA75_RS01960	COG2198	Histidine kinase
ISA75_RS01960	COG0784	Response regulator, receiver
ISA75_RS01960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA75_RS01960	COG2205	protein histidine kinase activity
ISA75_RS01970	COG3247	response to pH
ISA75_RS02040	COG2376	Dihydroxyacetone kinase
ISA75_RS02045	COG1461	Dihydroxyacetone kinase
ISA75_RS02060	COG2375	cellular response to nickel ion
ISA75_RS02065	COG1695	Transcriptional regulator
ISA75_RS02115	COG1902	pentaerythritol trinitrate reductase activity
ISA75_RS02115	COG0446	pyridine nucleotide-disulphide oxidoreductase
ISA75_RS02125	COG2211	Major facilitator Superfamily
ISA75_RS02135	COG3507	Belongs to the glycosyl hydrolase 43 family
ISA75_RS02140	COG1451	nucleotide metabolic process
ISA75_RS02145	COG0673	inositol 2-dehydrogenase activity
ISA75_RS02150	COG0861	Integral membrane protein TerC family
ISA75_RS02165	COG2721	sulfolactate sulfo-lyase activity
ISA75_RS02175	COG2271	Major facilitator Superfamily
ISA75_RS02180	COG2186	Transcriptional regulator
ISA75_RS02185	COG0586	Pfam SNARE associated Golgi protein
ISA75_RS02195	COG1422	Protein of unknown function (DUF1090)
ISA75_RS02200	COG4575	ribosome binding
ISA75_RS02205	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
ISA75_RS02215	COG2259	Doxx family
ISA75_RS02220	COG0435	Glutathione S-transferase
ISA75_RS02225	COG3152	Membrane
ISA75_RS02230	COG0583	DNA-binding transcription factor activity
ISA75_RS02235	COG1741	Belongs to the pirin family
ISA75_RS02260	COG1929	Belongs to the glycerate kinase type-1 family
ISA75_RS02265	COG2084	Dehydrogenase
ISA75_RS02275	COG2271	Major facilitator Superfamily
ISA75_RS02280	COG2721	sulfolactate sulfo-lyase activity
ISA75_RS02285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISA75_RS02290	COG1349	DNA-binding transcription factor activity
ISA75_RS02300	COG1105	Belongs to the carbohydrate kinase PfkB family
ISA75_RS02305	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISA75_RS02305	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISA75_RS02305	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA75_RS02310	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA75_RS02310	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA75_RS02320	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA75_RS02325	COG3414	Phosphotransferase system galactitol-specific IIB component
ISA75_RS02330	COG3775	system Galactitol-specific IIC component
ISA75_RS02335	COG1063	alcohol dehydrogenase
ISA75_RS02350	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ISA75_RS02370	COG2823	Periplasmic or secreted lipoprotein
ISA75_RS02375	COG0701	Predicted permease
ISA75_RS02380	COG0702	epimerase
ISA75_RS02385	COG0693	protein deglycase activity
ISA75_RS02400	COG3153	acetyltransferase
ISA75_RS02405	COG3154	lipid carrier protein
ISA75_RS02410	COG0826	peptidase U32
ISA75_RS02415	COG0826	peptidase U32
ISA75_RS02420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISA75_RS02425	COG0814	amino acid
ISA75_RS02470	COG0195	Participates in both transcription termination and antitermination
ISA75_RS02510	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ISA75_RS02520	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ISA75_RS02525	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ISA75_RS02535	COG1534	Rna-binding protein
ISA75_RS02545	COG2027	D-alanyl-D-alanine carboxypeptidase
ISA75_RS02555	COG0697	spore germination
ISA75_RS02570	COG0142	geranyltranstransferase activity
ISA75_RS02575	COG3423	Transcriptional regulator
ISA75_RS02585	COG5007	Belongs to the BolA IbaG family
ISA75_RS02590	COG3113	response to antibiotic
ISA75_RS02595	COG2854	intermembrane phospholipid transfer
ISA75_RS02600	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISA75_RS02605	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ISA75_RS02610	COG1127	ABC transporter
ISA75_RS02615	COG0530	calcium, potassium:sodium antiporter activity
ISA75_RS02625	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ISA75_RS02630	COG3117	lipopolysaccharide transmembrane transporter activity
ISA75_RS02635	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ISA75_RS02640	COG1137	ATPase activity
ISA75_RS02645	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ISA75_RS02650	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ISA75_RS02655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA75_RS02665	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA75_RS02670	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISA75_RS02675	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
ISA75_RS02680	COG5002	protein histidine kinase activity
ISA75_RS02680	COG2198	Histidine kinase
ISA75_RS02680	COG0784	Response regulator, receiver
ISA75_RS02685	COG1312	Catalyzes the dehydration of D-mannonate
ISA75_RS02690	COG1063	alcohol dehydrogenase
ISA75_RS02695	COG2271	Major facilitator Superfamily
ISA75_RS02700	COG1242	4 iron, 4 sulfur cluster binding
ISA75_RS02705	COG0070	glutamate synthase
ISA75_RS02705	COG0069	glutamate synthase activity
ISA75_RS02705	COG0067	glutamate synthase
ISA75_RS02710	COG0493	'glutamate synthase
ISA75_RS02720	COG2969	positive regulation of protein catabolic process
ISA75_RS02725	COG0625	glutathione transferase activity
ISA75_RS02745	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ISA75_RS02750	COG3105	Protein conserved in bacteria
ISA75_RS02755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISA75_RS02760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISA75_RS02785	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ISA75_RS02790	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ISA75_RS02795	COG0471	metal ion transport
ISA75_RS02805	COG1802	Transcriptional regulator
ISA75_RS02835	COG2732	(Barnase) inhibitor
ISA75_RS02840	COG1289	transmembrane transporter activity
ISA75_RS02855	COG0583	DNA-binding transcription factor activity
ISA75_RS02860	COG0312	modulator of DNA gyrase
ISA75_RS02865	COG3164	Protein of unknown function
ISA75_RS02870	COG1530	ribonuclease E activity
ISA75_RS02880	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ISA75_RS02885	COG1792	Involved in formation and maintenance of cell shape
ISA75_RS02890	COG1077	Cell shape determining protein MreB Mrl
ISA75_RS02895	COG2200	EAL domain
ISA75_RS02895	COG2199	diguanylate cyclase activity
ISA75_RS02920	COG0511	ligase activity, forming carbon-carbon bonds
ISA75_RS02925	COG0439	Biotin carboxylase
ISA75_RS02930	COG3924	membrane
ISA75_RS02935	COG4145	pantothenate transmembrane transporter activity
ISA75_RS02955	COG1309	transcriptional regulator
ISA75_RS02960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA75_RS02965	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISA75_RS03000	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ISA75_RS03020	COG0551	DNA topoisomerase type I activity
ISA75_RS03030	COG0758	DNA mediated transformation
ISA75_RS03060	COG3036	rescue of stalled ribosome
ISA75_RS03065	COG0789	Transcriptional regulator
ISA75_RS03080	COG0202	RNA polymerase activity
ISA75_RS03090	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ISA75_RS03105	COG0201	protein transport
ISA75_RS03170	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ISA75_RS03185	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ISA75_RS03210	COG0051	transcription antitermination factor activity, RNA binding
ISA75_RS03265	COG2964	Protein conserved in bacteria
ISA75_RS03270	COG0545	Peptidyl-prolyl cis-trans isomerase
ISA75_RS03280	COG1047	Peptidyl-prolyl cis-trans
ISA75_RS03285	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
ISA75_RS03300	COG0488	(ABC) transporter
ISA75_RS03305	COG0429	hydrolase of the alpha beta-hydrolase fold
ISA75_RS03315	COG3954	Phosphoribulokinase
ISA75_RS03320	COG1765	OsmC-like protein
ISA75_RS03330	COG1289	transmembrane transporter activity
ISA75_RS03335	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISA75_RS03360	COG0738	Major facilitator superfamily
ISA75_RS03365	COG0402	S-adenosylhomocysteine deaminase activity
ISA75_RS03370	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISA75_RS03395	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ISA75_RS03400	COG0338	D12 class N6 adenine-specific DNA methyltransferase
ISA75_RS03405	COG3266	domain, Protein
ISA75_RS03420	COG4796	Type ii and iii secretion system protein
ISA75_RS03445	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ISA75_RS03450	COG0494	nUDIX hydrolase
ISA75_RS03460	COG1011	Hydrolase
ISA75_RS03465	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ISA75_RS03490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISA75_RS03495	COG2183	response to ionizing radiation
ISA75_RS03500	COG1918	ferrous iron import across plasma membrane
ISA75_RS03525	COG1040	competence protein
ISA75_RS03535	COG2610	gluconate transmembrane transporter activity
ISA75_RS03540	COG1640	4-alpha-glucanotransferase
ISA75_RS03545	COG0058	SHG alpha-glucan phosphorylase activity
ISA75_RS03560	COG1349	DNA-binding transcription factor activity
ISA75_RS03575	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ISA75_RS03590	COG0058	SHG alpha-glucan phosphorylase activity
ISA75_RS03615	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ISA75_RS03625	COG2610	gluconate transmembrane transporter activity
ISA75_RS03630	COG3265	gluconokinase activity
ISA75_RS03635	COG1609	Transcriptional regulator
ISA75_RS03640	COG1741	Belongs to the pirin family
ISA75_RS03645	COG0673	inositol 2-dehydrogenase activity
ISA75_RS03655	COG1247	-acetyltransferase
ISA75_RS03670	COG0584	glycerophosphoryl diester phosphodiesterase
ISA75_RS03720	COG0559	Belongs to the binding-protein-dependent transport system permease family
ISA75_RS03725	COG0683	leucine binding
ISA75_RS03735	COG0683	leucine binding
ISA75_RS03745	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISA75_RS03760	COG2177	Part of the ABC transporter FtsEX involved in
ISA75_RS03765	COG2884	Cell division ATP-binding protein ftsE
ISA75_RS03770	COG0552	protein localization to endoplasmic reticulum
ISA75_RS03775	COG0742	ribosomal rna small subunit methyltransferase
ISA75_RS03780	COG3776	membrane
ISA75_RS03790	COG3714	YhhN family
ISA75_RS03805	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ISA75_RS03815	COG0477	Major facilitator Superfamily
ISA75_RS03820	COG0628	permease
ISA75_RS03860	COG3479	Phenolic acid decarboxylase
ISA75_RS03870	COG0747	negative chemotaxis
ISA75_RS03875	COG0601	transmembrane transport
ISA75_RS03880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISA75_RS03890	COG1124	(ABC) transporter
ISA75_RS03900	COG2239	Acts as a magnesium transporter
ISA75_RS03905	COG2081	HI0933 family
ISA75_RS03910	COG0306	phosphate transporter
ISA75_RS03920	COG0589	response to stress
ISA75_RS03940	COG0671	phosphoesterase, PA-phosphatase related
ISA75_RS03945	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ISA75_RS03950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISA75_RS03960	COG1454	alcohol dehydrogenase
ISA75_RS03970	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISA75_RS03975	COG1028	Short-chain dehydrogenase reductase Sdr
ISA75_RS03980	COG0583	DNA-binding transcription factor activity
ISA75_RS03985	COG1295	ribonuclease BN
ISA75_RS03990	COG0477	Major facilitator Superfamily
ISA75_RS03995	COG2982	Protein involved in outer membrane biogenesis
ISA75_RS04005	COG0612	Peptidase, M16
ISA75_RS04015	COG2199	diguanylate cyclase activity
ISA75_RS04015	COG2200	EAL domain
ISA75_RS04020	COG3118	belongs to the thioredoxin family
ISA75_RS04020	COG0457	Tetratricopeptide repeat
ISA75_RS04025	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ISA75_RS04030	COG1215	transferase activity, transferring glycosyl groups
ISA75_RS04060	COG2194	sulfuric ester hydrolase activity
ISA75_RS04075	COG0457	Tetratricopeptide repeat
ISA75_RS04080	COG1215	transferase activity, transferring glycosyl groups
ISA75_RS04090	COG2894	cell division
ISA75_RS04105	COG4608	Belongs to the ABC transporter superfamily
ISA75_RS04110	COG0444	Belongs to the ABC transporter superfamily
ISA75_RS04115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISA75_RS04120	COG0601	transmembrane transport
ISA75_RS04125	COG0747	negative chemotaxis
ISA75_RS04155	COG2223	nitrite transmembrane transporter activity
ISA75_RS04160	COG5571	outer membrane autotransporter
ISA75_RS04165	COG2818	Glycosylase
ISA75_RS04170	COG0456	acetyltransferase
ISA75_RS04175	COG0243	molybdopterin cofactor binding
ISA75_RS04180	COG2885	chlorophyll binding
ISA75_RS04185	COG1609	Transcriptional regulator
ISA75_RS04195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISA75_RS04215	COG2814	Major facilitator Superfamily
ISA75_RS04220	COG2944	sequence-specific DNA binding
ISA75_RS04225	COG1278	Cold shock
ISA75_RS04255	COG3274	enterobacterial common antigen metabolic process
ISA75_RS04260	COG4682	membrane
ISA75_RS04265	COG4682	membrane
ISA75_RS04280	COG4213	ABC transporter substrate-binding protein
ISA75_RS04290	COG4214	carbohydrate transport
ISA75_RS04295	COG2207	Transcriptional regulator
ISA75_RS04295	COG1609	Transcriptional regulator
ISA75_RS04300	COG2992	FlgJ-related protein
ISA75_RS04305	COG0366	Alpha amylase catalytic
ISA75_RS04310	COG3977	Valine--pyruvate aminotransferase
ISA75_RS04315	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISA75_RS04320	COG1414	Transcriptional regulator
ISA75_RS04325	COG3276	selenocysteine insertion sequence binding
ISA75_RS04335	COG0625	glutathione transferase activity
ISA75_RS04340	COG1566	PFAM secretion protein HlyD family protein
ISA75_RS04360	COG3722	fumarate hydratase activity
ISA75_RS04380	COG2186	Transcriptional regulator
ISA75_RS04390	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ISA75_RS04410	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ISA75_RS04415	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ISA75_RS04425	COG4942	peptidase
ISA75_RS04430	COG2861	carbohydrate metabolic process
ISA75_RS04435	COG0463	Glycosyl transferase, family 2
ISA75_RS04445	COG0156	8-amino-7-oxononanoate synthase activity
ISA75_RS04460	COG0859	PFAM glycosyl transferase family 9
ISA75_RS04485	COG0859	PFAM glycosyl transferase family 9
ISA75_RS04495	COG0438	transferase activity, transferring glycosyl groups
ISA75_RS04500	COG1216	Glycosyl transferase, family 2
ISA75_RS04505	COG1519	Transferase
ISA75_RS04530	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ISA75_RS04540	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ISA75_RS04570	COG0842	Transport permease protein
ISA75_RS04575	COG1131	(ABC) transporter
ISA75_RS04590	COG1561	YicC-like family, N-terminal region
ISA75_RS04600	COG2169	Transcriptional regulator
ISA75_RS04600	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ISA75_RS04610	COG2860	membrane
ISA75_RS04630	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISA75_RS04635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISA75_RS04640	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ISA75_RS04645	COG1494	fructose-1,6-bisphosphatase
ISA75_RS04655	COG3152	Membrane
ISA75_RS04680	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ISA75_RS04685	COG3074	FtsZ-dependent cytokinesis
ISA75_RS04700	COG0786	glutamate:sodium symporter activity
ISA75_RS04705	COG2233	PERMEase
ISA75_RS04710	COG2982	Protein involved in outer membrane biogenesis
ISA75_RS04715	COG1263	PTS System
ISA75_RS04715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA75_RS04720	COG1486	melibiose metabolic process
ISA75_RS04730	COG1501	Belongs to the glycosyl hydrolase 31 family
ISA75_RS04735	COG2211	Major facilitator Superfamily
ISA75_RS04785	COG1064	alcohol dehydrogenase
ISA75_RS04795	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ISA75_RS04810	COG1464	Belongs to the NlpA lipoprotein family
ISA75_RS04835	COG0583	DNA-binding transcription factor activity
ISA75_RS04845	COG1309	transcriptional regulator
ISA75_RS04870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISA75_RS04880	COG2814	Major facilitator Superfamily
ISA75_RS04890	COG1263	PTS System
ISA75_RS04890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA75_RS04895	COG0697	spore germination
ISA75_RS04910	COG2828	Protein conserved in bacteria
ISA75_RS04915	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ISA75_RS04920	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ISA75_RS04930	COG3384	dioxygenase
ISA75_RS04940	COG1609	Transcriptional regulator
ISA75_RS04950	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA75_RS04950	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA75_RS04955	COG1447	Phosphotransferase system cellobiose-specific component IIA
ISA75_RS04960	COG4580	involved in the transport of maltose and maltodextrins
ISA75_RS04980	COG0583	DNA-binding transcription factor activity
ISA75_RS04990	COG2271	Major facilitator Superfamily
ISA75_RS05000	COG2197	response regulator
ISA75_RS05005	COG0440	acetolactate synthase activity
ISA75_RS05010	COG0028	Belongs to the TPP enzyme family
ISA75_RS05040	COG2814	Major facilitator Superfamily
ISA75_RS05045	COG0583	DNA-binding transcription factor activity
ISA75_RS05055	COG2610	gluconate transmembrane transporter activity
ISA75_RS05075	COG2149	membrane
ISA75_RS05090	COG2188	Transcriptional regulator
ISA75_RS05110	COG5645	(Lipo)protein
ISA75_RS05115	COG0823	Involved in the tonB-independent uptake of proteins
ISA75_RS05130	COG0561	phosphatase activity
ISA75_RS05145	COG0592	DNA-directed DNA polymerase activity
ISA75_RS05165	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ISA75_RS05195	COG2091	lysine biosynthetic process via aminoadipic acid
ISA75_RS05200	COG0431	NADPH-dependent FMN reductase
ISA75_RS05205	COG2252	PERMEase
ISA75_RS05210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISA75_RS05215	COG0363	glucosamine-6-phosphate deaminase activity
ISA75_RS05220	COG2382	esterase
ISA75_RS05230	COG0704	Plays a role in the regulation of phosphate uptake
ISA75_RS05235	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ISA75_RS05240	COG0581	inorganic phosphate transmembrane transporter activity
ISA75_RS05245	COG0573	inorganic phosphate transmembrane transporter activity
ISA75_RS05250	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ISA75_RS05255	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ISA75_RS05305	COG3312	ion transport
ISA75_RS05320	COG0716	FMN binding
ISA75_RS05325	COG1522	sequence-specific DNA binding
ISA75_RS05355	COG1129	ABC transporter
ISA75_RS05360	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA75_RS05370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISA75_RS05375	COG1609	Transcriptional regulator
ISA75_RS05380	COG0477	Major facilitator Superfamily
ISA75_RS05385	COG2186	Transcriptional regulator
ISA75_RS05410	COG1763	Mo-molybdopterin cofactor biosynthetic process
ISA75_RS05420	COG3084	Protein conserved in bacteria
ISA75_RS05425	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ISA75_RS05435	COG0204	Acyl-transferase
ISA75_RS05455	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISA75_RS05470	COG3852	Histidine kinase
ISA75_RS05485	COG1011	Hydrolase
ISA75_RS05500	COG0456	acetyltransferase
ISA75_RS05505	COG0657	acetylesterase activity
ISA75_RS05510	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ISA75_RS05525	COG2864	formate dehydrogenase
ISA75_RS05530	COG0437	4 iron, 4 sulfur cluster binding
ISA75_RS05550	COG0205	6-phosphofructokinase activity
ISA75_RS05610	COG2211	Major facilitator Superfamily
ISA75_RS05615	COG0110	maltose O-acetyltransferase activity
ISA75_RS05625	COG1454	alcohol dehydrogenase
ISA75_RS05630	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA75_RS05635	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA75_RS05640	COG1129	ABC transporter
ISA75_RS05680	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ISA75_RS05685	COG2258	MOSC domain
ISA75_RS05690	COG2205	protein histidine kinase activity
ISA75_RS05695	COG0745	RESPONSE REGULATOR receiver
ISA75_RS05700	COG3678	ATP-independent chaperone mediated protein folding
ISA75_RS05720	COG1575	Belongs to the MenA family. Type 1 subfamily
ISA75_RS05735	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ISA75_RS05740	COG1609	Transcriptional regulator
ISA75_RS05745	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ISA75_RS05760	COG0626	cystathionine gamma-synthase activity
ISA75_RS05765	COG0527	aspartate kinase activity
ISA75_RS05765	COG0460	homoserine dehydrogenase
ISA75_RS05775	COG0583	DNA-binding transcription factor activity
ISA75_RS05785	COG0371	Dehydrogenase
ISA75_RS05795	COG2207	Transcriptional regulator
ISA75_RS05800	COG3443	Belongs to the bacterial solute-binding protein 9 family
ISA75_RS05815	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ISA75_RS05830	COG0583	DNA-binding transcription factor activity
ISA75_RS05905	COG3085	chromosome segregation
ISA75_RS05925	COG3978	acetolactate synthase activity
ISA75_RS05930	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISA75_RS05940	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ISA75_RS05945	COG0583	DNA-binding transcription factor activity
ISA75_RS05955	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISA75_RS05960	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISA75_RS05970	COG1811	Na channel or pump
ISA75_RS05995	COG3118	belongs to the thioredoxin family
ISA75_RS06000	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ISA75_RS06005	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ISA75_RS06015	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ISA75_RS06020	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ISA75_RS06025	COG1088	dTDP-glucose 4,6-dehydratase activity
ISA75_RS06030	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ISA75_RS06035	COG0456	acetyltransferase
ISA75_RS06040	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ISA75_RS06045	COG2244	polysaccharide biosynthetic process
ISA75_RS06090	COG3071	HemY protein
ISA75_RS06095	COG2959	enzyme of heme biosynthesis
ISA75_RS06110	COG3072	Adenylate cyclase
ISA75_RS06140	COG1011	Hydrolase
ISA75_RS06145	COG0210	DNA helicase
ISA75_RS06175	COG1280	lysine exporter protein (LysE YggA)
ISA75_RS06185	COG1280	lysine exporter protein (LysE YggA)
ISA75_RS06190	COG2267	carboxylic ester hydrolase activity
ISA75_RS06195	COG0561	phosphatase activity
ISA75_RS06200	COG0697	spore germination
ISA75_RS06205	COG0583	DNA-binding transcription factor activity
ISA75_RS06215	COG0412	Dienelactone hydrolase
ISA75_RS06235	COG3165	ubiquinone biosynthetic process from chorismate
ISA75_RS06255	COG0805	protein transport
ISA75_RS06295	COG1739	Uncharacterized protein family UPF0029
ISA75_RS06305	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ISA75_RS06335	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ISA75_RS06380	COG0250	Participates in transcription elongation, termination and antitermination
ISA75_RS06415	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ISA75_RS06420	COG1447	Phosphotransferase system cellobiose-specific component IIA
ISA75_RS06430	COG3706	GGDEF domain
ISA75_RS06435	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ISA75_RS06445	COG2104	thiamine diphosphate biosynthetic process
ISA75_RS06450	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ISA75_RS06465	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
ISA75_RS06505	COG4191	Histidine kinase
ISA75_RS06515	COG0151	Belongs to the GarS family
ISA75_RS06545	COG0456	acetyltransferase
ISA75_RS06555	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ISA75_RS06585	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ISA75_RS06650	COG0527	aspartate kinase activity
ISA75_RS06660	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ISA75_RS06720	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ISA75_RS06730	COG0534	Mate efflux family protein
ISA75_RS06735	COG3237	CsbD-like
ISA75_RS06740	COG0735	belongs to the Fur family
ISA75_RS06750	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISA75_RS06765	COG0305	Participates in initiation and elongation during chromosome replication
ISA75_RS06770	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ISA75_RS06785	COG0432	Pfam Uncharacterised protein family UPF0047
ISA75_RS06790	COG2315	Protein conserved in bacteria
ISA75_RS06800	COG0629	single-stranded DNA binding
ISA75_RS06805	COG0741	lytic transglycosylase activity
ISA75_RS06810	COG4771	TonB-dependent receptor
ISA75_RS06825	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISA75_RS06835	COG0583	DNA-binding transcription factor activity
ISA75_RS06845	COG0483	inositol monophosphate 1-phosphatase activity
ISA75_RS06850	COG1609	Transcriptional regulator
ISA75_RS06855	COG1234	tRNA 3'-trailer cleavage
ISA75_RS06885	COG4943	cyclic-guanylate-specific phosphodiesterase activity
ISA75_RS06895	COG0789	Transcriptional regulator
ISA75_RS06900	COG0625	glutathione transferase activity
ISA75_RS06905	COG2252	PERMEase
ISA75_RS06910	COG0025	NhaP-type Na H and K H
ISA75_RS06915	COG0583	DNA-binding transcription factor activity
ISA75_RS06920	COG1380	Effector of murein hydrolase LrgA
ISA75_RS06925	COG1346	cytolysis
ISA75_RS06930	COG3539	Fimbrial protein
ISA75_RS06960	COG3162	membrane
ISA75_RS06975	COG1301	dicarboxylic acid transport
ISA75_RS06980	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
ISA75_RS07015	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA75_RS07020	COG1129	ABC transporter
ISA75_RS07025	COG0784	Response regulator, receiver
ISA75_RS07025	COG4191	Histidine kinase
ISA75_RS07035	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ISA75_RS07045	COG3454	Phosphonate metabolism
ISA75_RS07050	COG4778	phosphonate C-P lyase system protein PhnL
ISA75_RS07055	COG4107	phosphonate C-P lyase system protein PhnK
ISA75_RS07060	COG3627	carbon phosphorus lyase activity
ISA75_RS07065	COG3626	phosphonate metabolism
ISA75_RS07070	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
ISA75_RS07075	COG3624	Phosphonate C-P lyase system protein PhnG
ISA75_RS07080	COG2188	Transcriptional regulator
ISA75_RS07085	COG2764	glyoxalase bleomycin resistance protein dioxygenase
ISA75_RS07090	COG2824	Alkylphosphonate utilization operon protein PhnA
ISA75_RS07100	COG2169	Transcriptional regulator
ISA75_RS07105	COG1486	melibiose metabolic process
ISA75_RS07140	COG0861	Integral membrane protein TerC family
ISA75_RS07155	COG1215	transferase activity, transferring glycosyl groups
ISA75_RS07160	COG1649	PFAM Uncharacterised BCR, COG1649
ISA75_RS07160	COG0726	polysaccharide deacetylase
ISA75_RS07165	COG0457	Tetratricopeptide repeat
ISA75_RS07195	COG1309	transcriptional regulator
ISA75_RS07210	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ISA75_RS07215	COG1027	Aspartate ammonia-lyase
ISA75_RS07220	COG3030	protein affecting phage T7 exclusion by the F plasmid
ISA75_RS07225	COG0531	amino acid
ISA75_RS07290	COG1509	lysine 2,3-aminomutase activity
ISA75_RS07310	COG2076	Multidrug Resistance protein
ISA75_RS07330	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ISA75_RS07335	COG1053	succinate dehydrogenase
ISA75_RS07350	COG3264	Mechanosensitive ion channel
ISA75_RS07350	COG1511	domain protein
ISA75_RS07370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA75_RS07390	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ISA75_RS07395	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ISA75_RS07395	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ISA75_RS07400	COG0802	atpase or kinase
ISA75_RS07425	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ISA75_RS07430	COG0330	HflC and HflK could
ISA75_RS07435	COG0330	HflC and HflK could
ISA75_RS07445	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ISA75_RS07460	COG0557	exoribonuclease II activity
ISA75_RS07465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISA75_RS07470	COG1960	acyl-CoA dehydrogenase activity
ISA75_RS07480	COG3650	response to hydrogen peroxide
ISA75_RS07485	COG1073	alpha beta
ISA75_RS07545	COG2965	DNA replication, synthesis of RNA primer
ISA75_RS07550	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ISA75_RS07560	COG3061	Opacity-associated protein A
ISA75_RS07565	COG0545	Peptidyl-prolyl cis-trans isomerase
ISA75_RS07570	COG1113	amino acid transport
ISA75_RS07580	COG0697	spore germination
ISA75_RS07590	COG0702	epimerase
ISA75_RS07595	COG1733	regulation of RNA biosynthetic process
ISA75_RS07610	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ISA75_RS07625	COG1253	flavin adenine dinucleotide binding
ISA75_RS07630	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ISA75_RS07635	COG1609	Transcriptional regulator
ISA75_RS07640	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISA75_RS07645	COG1914	H( )-stimulated, divalent metal cation uptake system
ISA75_RS07660	COG0729	surface antigen
ISA75_RS07665	COG2911	Protein conserved in bacteria
ISA75_RS07670	COG2105	PFAM AIG2 family protein
ISA75_RS07685	COG1879	ABC-type sugar transport system periplasmic component
ISA75_RS07690	COG1129	ABC transporter
ISA75_RS07695	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA75_RS07700	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA75_RS07710	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ISA75_RS07735	COG0312	modulator of DNA gyrase
ISA75_RS07775	COG3964	amidohydrolase
ISA75_RS07790	COG2706	6-phosphogluconolactonase activity
ISA75_RS07795	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA75_RS07795	COG3711	transcriptional antiterminator
ISA75_RS07800	COG0602	queuosine metabolic process
ISA75_RS07810	COG0366	Alpha amylase catalytic
ISA75_RS07815	COG1263	PTS System
ISA75_RS07815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA75_RS07850	COG2731	YhcH YjgK YiaL family protein
ISA75_RS07875	COG0525	valine-tRNA ligase activity
ISA75_RS07880	COG2927	DNA polymerase III (CHI subunit)
ISA75_RS07890	COG0795	lipopolysaccharide-transporting ATPase activity
ISA75_RS07895	COG0795	lipopolysaccharide-transporting ATPase activity
ISA75_RS07900	COG0433	COG0433 Predicted ATPase
ISA75_RS07915	COG3718	enzyme involved in inositol metabolism
ISA75_RS07920	COG0837	glucose binding
ISA75_RS07920	COG1737	Transcriptional regulator
ISA75_RS07925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISA75_RS07930	COG3962	Belongs to the TPP enzyme family
ISA75_RS07940	COG1082	Xylose isomerase domain protein TIM barrel
ISA75_RS07950	COG1653	transport
ISA75_RS07955	COG3842	ATPase activity
ISA75_RS07960	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ISA75_RS07965	COG0395	ABC-type sugar transport system, permease component
ISA75_RS07970	COG1175	transmembrane transport
ISA75_RS07975	COG1064	alcohol dehydrogenase
ISA75_RS07980	COG0659	secondary active sulfate transmembrane transporter activity
ISA75_RS07985	COG0288	reversible hydration of carbon dioxide
ISA75_RS08005	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ISA75_RS08125	COG3507	Belongs to the glycosyl hydrolase 43 family
ISA75_RS08130	COG2211	Major facilitator Superfamily
ISA75_RS08135	COG2115	Belongs to the xylose isomerase family
ISA75_RS08140	COG4580	involved in the transport of maltose and maltodextrins
ISA75_RS08145	COG3272	Protein of unknown function (DUF1722)
ISA75_RS08165	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ISA75_RS08180	COG0300	oxidoreductase activity
ISA75_RS08185	COG3631	Ketosteroid isomerase-related protein
ISA75_RS08190	COG0789	Transcriptional regulator
ISA75_RS08195	COG3040	lipid binding
ISA75_RS08205	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISA75_RS08210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA75_RS08215	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA75_RS08220	COG1538	Outer membrane efflux protein
ISA75_RS08225	COG0745	RESPONSE REGULATOR receiver
ISA75_RS08230	COG5002	protein histidine kinase activity
ISA75_RS08235	COG2850	peptidyl-arginine hydroxylation
ISA75_RS08270	COG0842	Transport permease protein
ISA75_RS08275	COG0842	Transport permease protein
ISA75_RS08275	COG1129	ABC transporter
ISA75_RS08280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA75_RS08285	COG3706	GGDEF domain
ISA75_RS08295	COG1879	ABC-type sugar transport system periplasmic component
ISA75_RS08300	COG1129	ABC transporter
ISA75_RS08305	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA75_RS08315	COG2249	NAD(P)H dehydrogenase (quinone) activity
ISA75_RS08320	COG0583	DNA-binding transcription factor activity
ISA75_RS08330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISA75_RS08335	COG5457	Domain of unknown function (DUF1127)
ISA75_RS08345	COG1566	PFAM secretion protein HlyD family protein
ISA75_RS08355	COG0583	DNA-binding transcription factor activity
ISA75_RS08360	COG3366	ferrous iron transmembrane transporter activity
ISA75_RS08365	COG0700	Nucleoside recognition
ISA75_RS08370	COG1473	amidohydrolase
ISA75_RS08380	COG1924	4 iron, 4 sulfur cluster binding
ISA75_RS08385	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
ISA75_RS08400	COG2733	membrane
ISA75_RS08410	COG1917	Cupin 2, conserved barrel domain protein
ISA75_RS08410	COG2207	Transcriptional regulator
ISA75_RS08415	COG5464	transposase or invertase
ISA75_RS08420	COG1012	belongs to the aldehyde dehydrogenase family
ISA75_RS08430	COG0523	cobalamin synthesis protein
ISA75_RS08435	COG2879	small protein
ISA75_RS08440	COG1966	Carbon starvation protein
ISA75_RS08445	COG2831	hemolysin activation secretion protein
ISA75_RS08450	COG3210	domain, Protein
ISA75_RS08465	COG3210	domain, Protein
ISA75_RS08485	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ISA75_RS08490	COG2368	4-hydroxyphenylacetate
ISA75_RS08510	COG3971	2-oxopent-4-enoate hydratase activity
ISA75_RS08520	COG3384	dioxygenase
ISA75_RS08525	COG1012	belongs to the aldehyde dehydrogenase family
ISA75_RS08535	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISA75_RS08545	COG1846	Transcriptional regulator
ISA75_RS08560	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ISA75_RS08560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISA75_RS08575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISA75_RS08580	COG1012	belongs to the aldehyde dehydrogenase family
ISA75_RS08585	COG0531	amino acid
ISA75_RS08600	COG0456	acetyltransferase
ISA75_RS08600	COG1214	PFAM Peptidase M22, glycoprotease
ISA75_RS08605	COG2271	Major facilitator Superfamily
ISA75_RS08610	COG1802	Transcriptional regulator
ISA75_RS08615	COG1063	alcohol dehydrogenase
ISA75_RS08625	COG3933	PFAM sigma-54 factor interaction domain-containing protein
ISA75_RS08625	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ISA75_RS08640	COG3715	PTS system
ISA75_RS08645	COG3716	PTS system mannose fructose sorbose family IID component
ISA75_RS08650	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ISA75_RS08675	COG1484	DNA-dependent DNA replication
ISA75_RS08690	COG2966	Psort location CytoplasmicMembrane, score
ISA75_RS08700	COG1917	Cupin 2, conserved barrel domain protein
ISA75_RS08700	COG2169	Transcriptional regulator
ISA75_RS08705	COG2197	response regulator
ISA75_RS08710	COG2197	response regulator
ISA75_RS08715	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ISA75_RS08720	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA75_RS08725	COG4114	ferric iron reductase
ISA75_RS08730	COG3706	GGDEF domain
ISA75_RS08765	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
ISA75_RS08770	COG0456	acetyltransferase
ISA75_RS08775	COG1011	Hydrolase
ISA75_RS08785	COG2823	Periplasmic or secreted lipoprotein
ISA75_RS08795	COG4667	esterase of the alpha-beta hydrolase superfamily
ISA75_RS08800	COG0084	hydrolase, TatD family'
ISA75_RS08830	COG3726	membrane protein affecting hemolysin expression
ISA75_RS08835	COG0560	Phosphoserine phosphatase
ISA75_RS08840	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ISA75_RS08850	COG0488	(ABC) transporter
ISA75_RS08855	COG0741	lytic transglycosylase activity
ISA75_RS08875	COG3708	Transcriptional regulator
ISA75_RS08875	COG2207	Transcriptional regulator
ISA75_RS08880	COG3045	CreA protein
ISA75_RS08885	COG0745	RESPONSE REGULATOR receiver
ISA75_RS08890	COG2205	protein histidine kinase activity
ISA75_RS08895	COG4452	Inner membrane protein CreD
ISA75_RS08900	COG0745	RESPONSE REGULATOR receiver
ISA75_RS08910	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ISA75_RS08920	COG0527	aspartate kinase activity
ISA75_RS08920	COG0460	homoserine dehydrogenase
ISA75_RS08930	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ISA75_RS08945	COG1115	amino acid carrier protein
ISA75_RS08950	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISA75_RS08955	COG0521	Mo-molybdopterin cofactor biosynthetic process
ISA75_RS08960	COG0477	Major facilitator Superfamily
ISA75_RS08965	COG1584	GPR1 FUN34 yaaH family protein
ISA75_RS08970	COG4735	regulation of single-species biofilm formation
ISA75_RS08995	COG0583	DNA-binding transcription factor activity
ISA75_RS09005	COG0196	riboflavin kinase activity
ISA75_RS09020	COG1047	Peptidyl-prolyl cis-trans
ISA75_RS09035	COG0583	DNA-binding transcription factor activity
ISA75_RS09040	COG2828	Protein conserved in bacteria
ISA75_RS09045	COG0471	metal ion transport
ISA75_RS09050	COG0471	metal ion transport
ISA75_RS09055	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ISA75_RS09135	COG0505	Belongs to the CarA family
ISA75_RS09150	COG2731	YhcH YjgK YiaL family protein
ISA75_RS09155	COG3265	gluconokinase activity
ISA75_RS09160	COG1028	Short-chain dehydrogenase reductase Sdr
ISA75_RS09165	COG1609	Transcriptional regulator
ISA75_RS09170	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ISA75_RS09175	COG2271	Major facilitator Superfamily
ISA75_RS09210	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ISA75_RS09220	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ISA75_RS09225	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ISA75_RS09240	COG3493	citrate carrier protein
ISA75_RS09250	COG0564	pseudouridine synthase activity
ISA75_RS09260	COG0417	DNA replication proofreading
ISA75_RS09265	COG0235	Class ii aldolase
ISA75_RS09285	COG0586	Pfam SNARE associated Golgi protein
ISA75_RS09295	COG1178	ABC-type Fe3 transport system permease component
ISA75_RS09315	COG2814	Major facilitator Superfamily
ISA75_RS09320	COG2271	Major facilitator Superfamily
ISA75_RS09325	COG0583	DNA-binding transcription factor activity
ISA75_RS09335	COG0738	Major facilitator superfamily
ISA75_RS09340	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ISA75_RS09380	COG0028	Belongs to the TPP enzyme family
ISA75_RS09390	COG1609	Transcriptional regulator
ISA75_RS09410	COG0768	penicillin binding
ISA75_RS09420	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ISA75_RS09435	COG0772	Belongs to the SEDS family
ISA75_RS09450	COG1181	Belongs to the D-alanine--D-alanine ligase family
ISA75_RS09460	COG0849	cell division
ISA75_RS09465	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ISA75_RS09485	COG0494	nUDIX hydrolase
ISA75_RS09510	COG1459	type II secretion system
ISA75_RS09515	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISA75_RS09520	COG4969	Belongs to the N-Me-Phe pilin family
ISA75_RS09530	COG3023	N-Acetylmuramoyl-L-alanine amidase
ISA75_RS09535	COG3725	Membrane protein required for beta-lactamase induction
ISA75_RS09540	COG3940	Belongs to the glycosyl hydrolase 43 family
ISA75_RS09545	COG2211	Major facilitator Superfamily
ISA75_RS09550	COG1113	amino acid transport
ISA75_RS09555	COG2186	Transcriptional regulator
ISA75_RS09560	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ISA75_RS09565	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISA75_RS09570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISA75_RS09585	COG3064	Membrane
ISA75_RS09610	COG0545	Peptidyl-prolyl cis-trans isomerase
ISA75_RS09625	COG2132	Multicopper oxidase
ISA75_RS09630	COG4993	Dehydrogenase
ISA75_RS09645	COG0288	reversible hydration of carbon dioxide
ISA75_RS09650	COG1131	(ABC) transporter
ISA75_RS09655	COG0842	Transport permease protein
ISA75_RS09660	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA75_RS09665	COG0726	polysaccharide deacetylase
ISA75_RS09685	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ISA75_RS09690	COG0617	tRNA 3'-terminal CCA addition
ISA75_RS09710	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ISA75_RS09715	COG1643	Atp-dependent helicase
ISA75_RS09805	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISA75_RS09810	COG4774	siderophore transport
ISA75_RS09815	COG1120	ATPase activity
ISA75_RS09820	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISA75_RS09825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA75_RS09845	COG2860	membrane
ISA75_RS09865	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISA75_RS09870	COG3835	regulator
ISA75_RS09885	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ISA75_RS09890	COG0024	Methionine aminopeptidase
ISA75_RS09925	COG0575	Belongs to the CDS family
ISA75_RS09930	COG0750	zinc metalloprotease
ISA75_RS09940	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
ISA75_RS09980	COG1982	Orn Lys Arg decarboxylase major
ISA75_RS09985	COG0346	lactoylglutathione lyase activity
ISA75_RS09995	COG4568	rho-dependent transcription termination
ISA75_RS10010	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ISA75_RS10015	COG3015	lipoprotein NlpE involved in copper resistance
ISA75_RS10020	COG0791	NLP P60 protein
ISA75_RS10030	COG1720	tRNA m6t6A37 methyltransferase activity
ISA75_RS10040	COG1464	Belongs to the NlpA lipoprotein family
ISA75_RS10045	COG2011	ABC-type metal ion transport system permease component
ISA75_RS10055	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ISA75_RS10090	COG0656	L-ascorbic acid biosynthetic process
ISA75_RS10095	COG0583	DNA-binding transcription factor activity
ISA75_RS10100	COG2814	Major facilitator Superfamily
ISA75_RS10110	COG2226	methyltransferase
ISA75_RS10115	COG1388	LysM domain
ISA75_RS10115	COG0741	lytic transglycosylase activity
ISA75_RS10125	COG2226	methyltransferase
ISA75_RS10145	COG0583	DNA-binding transcription factor activity
ISA75_RS10160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISA75_RS10165	COG1960	acyl-CoA dehydrogenase activity
ISA75_RS10175	COG0121	glutamine amidotransferase
ISA75_RS10180	COG3034	peptidoglycan biosynthetic process
ISA75_RS10195	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ISA75_RS10200	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ISA75_RS10215	COG2991	Protein conserved in bacteria
ISA75_RS10230	COG0454	-acetyltransferase
ISA75_RS10235	COG2195	Cleaves the N-terminal amino acid of tripeptides
ISA75_RS10255	COG1802	Transcriptional regulator
ISA75_RS10260	COG1113	amino acid transport
ISA75_RS10265	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISA75_RS10270	COG1012	belongs to the aldehyde dehydrogenase family
ISA75_RS10275	COG0579	oxidoreductase
ISA75_RS10290	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ISA75_RS10295	COG0625	glutathione transferase activity
ISA75_RS10305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISA75_RS10310	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISA75_RS10315	COG0022	dehydrogenase e1 component
ISA75_RS10320	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ISA75_RS10330	COG0519	Catalyzes the synthesis of GMP from XMP
ISA75_RS10330	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ISA75_RS10340	COG2207	Transcriptional regulator
ISA75_RS10360	COG1116	anion transmembrane transporter activity
ISA75_RS10365	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISA75_RS10370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISA75_RS10440	COG0791	NLP P60 protein
ISA75_RS10455	COG3639	organic phosphonate transmembrane transporter activity
ISA75_RS10465	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ISA75_RS10490	COG3188	usher protein
ISA75_RS10505	COG0765	amino acid transport
ISA75_RS10510	COG4597	amino acid ABC transporter
ISA75_RS10515	COG1126	abc transporter atp-binding protein
ISA75_RS10520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA75_RS10560	COG4302	ethanolamine ammonia-lyase activity
ISA75_RS10565	COG4303	Ethanolamine ammonia lyase large subunit
ISA75_RS10580	COG0833	amino acid
ISA75_RS10585	COG2040	homocysteine
ISA75_RS10590	COG4521	taurine ABC transporter
ISA75_RS10595	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
ISA75_RS10600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISA75_RS10605	COG2175	clavaminate synthase activity
ISA75_RS10615	COG1943	Transposase
ISA75_RS10620	COG0113	porphobilinogen synthase activity
ISA75_RS10625	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ISA75_RS10630	COG1335	isochorismatase
ISA75_RS10635	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
ISA75_RS10675	COG1785	Belongs to the alkaline phosphatase family
ISA75_RS10685	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ISA75_RS10695	COG3416	Protein conserved in bacteria
ISA75_RS10700	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ISA75_RS10710	COG4126	flavin adenine dinucleotide binding
ISA75_RS10725	COG1940	carbohydrate kinase activity
ISA75_RS10730	COG0419	ATPase involved in DNA repair
ISA75_RS10735	COG0420	3'-5' exonuclease activity
ISA75_RS10765	COG0366	Alpha amylase catalytic
ISA75_RS10770	COG0583	DNA-binding transcription factor activity
ISA75_RS10775	COG1335	isochorismatase
ISA75_RS10785	COG1228	amidohydrolase
ISA75_RS10795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISA75_RS10810	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA75_RS10820	COG0450	alkyl hydroperoxide reductase
ISA75_RS10845	COG1862	Preprotein translocase
ISA75_RS10850	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISA75_RS10855	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISA75_RS10875	COG4238	major outer membrane lipoprotein
ISA75_RS10885	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISA75_RS10885	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISA75_RS10900	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ISA75_RS10905	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ISA75_RS10910	COG0667	Aldo Keto reductase
ISA75_RS10920	COG0142	geranyltranstransferase activity
ISA75_RS10945	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ISA75_RS10955	COG2814	Major facilitator Superfamily
ISA75_RS10960	COG0673	inositol 2-dehydrogenase activity
ISA75_RS10975	COG1053	succinate dehydrogenase
ISA75_RS10985	COG1053	succinate dehydrogenase
ISA75_RS10990	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ISA75_RS10995	COG1414	Transcriptional regulator
ISA75_RS11010	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ISA75_RS11015	COG1845	cytochrome c oxidase, subunit III
ISA75_RS11020	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISA75_RS11025	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ISA75_RS11030	COG2223	nitrite transmembrane transporter activity
ISA75_RS11035	COG3056	Lipoprotein
ISA75_RS11040	COG0271	Belongs to the BolA IbaG family
ISA75_RS11060	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ISA75_RS11065	COG0776	regulation of translation
ISA75_RS11070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISA75_RS11075	COG1555	photosystem II stabilization
ISA75_RS11080	COG0824	Thioesterase
ISA75_RS11090	COG4533	DNA binding
ISA75_RS11105	COG1522	sequence-specific DNA binding
ISA75_RS11110	COG1132	(ABC) transporter
ISA75_RS11115	COG1132	(ABC) transporter
ISA75_RS11120	COG0347	Belongs to the P(II) protein family
ISA75_RS11125	COG0004	ammonium transporteR
ISA75_RS11130	COG1946	Acyl-CoA thioesterase
ISA75_RS11135	COG3126	Type III secretion system lipoprotein chaperone (YscW)
ISA75_RS11140	COG3695	enzyme binding
ISA75_RS11170	COG2364	Membrane
ISA75_RS11185	COG4943	cyclic-guanylate-specific phosphodiesterase activity
ISA75_RS11195	COG2182	Extracellular solute-binding protein
ISA75_RS11200	COG1175	transmembrane transport
ISA75_RS11205	COG3833	ABC-type maltose transport systems, permease component
ISA75_RS11210	COG3867	Arabinogalactan endo-beta-1,4-galactanase
ISA75_RS11215	COG1874	Beta-galactosidase
ISA75_RS11265	COG0110	maltose O-acetyltransferase activity
ISA75_RS11280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISA75_RS11285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA75_RS11290	COG1309	transcriptional regulator
ISA75_RS11295	COG1196	nuclear chromosome segregation
ISA75_RS11295	COG3264	Mechanosensitive ion channel
ISA75_RS11310	COG3923	Primosomal replication protein n
ISA75_RS11315	COG2832	Protein of unknown function (DUF454)
ISA75_RS11355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISA75_RS11360	COG4651	solute:proton antiporter activity
ISA75_RS11360	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISA75_RS11365	COG2223	nitrite transmembrane transporter activity
ISA75_RS11375	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ISA75_RS11380	COG3735	TraB family
ISA75_RS11395	COG1585	Membrane protein implicated in regulation of membrane protease activity
ISA75_RS11400	COG0330	HflC and HflK could
ISA75_RS11405	COG4619	ABC transporter
ISA75_RS11410	COG0390	transport system, permease component
ISA75_RS11415	COG3118	belongs to the thioredoxin family
ISA75_RS11420	COG0300	oxidoreductase activity
ISA75_RS11425	COG2755	lipolytic protein G-D-S-L family
ISA75_RS11430	COG4181	ATPase activity
ISA75_RS11435	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ISA75_RS11455	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ISA75_RS11460	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ISA75_RS11475	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISA75_RS11485	COG2501	S4 domain
ISA75_RS11550	COG3539	Fimbrial protein
ISA75_RS11555	COG3121	Chaperone
ISA75_RS11560	COG3188	usher protein
ISA75_RS11575	COG1560	Kdo2-lipid A biosynthetic process
ISA75_RS11585	COG3710	Transcriptional regulator
ISA75_RS11590	COG0531	amino acid
ISA75_RS11595	COG1982	Orn Lys Arg decarboxylase major
ISA75_RS11600	COG3104	oligopeptide transport
ISA75_RS11635	COG0673	inositol 2-dehydrogenase activity
ISA75_RS11650	COG1129	ABC transporter
ISA75_RS11655	COG4211	Belongs to the binding-protein-dependent transport system permease family
ISA75_RS11700	COG1566	PFAM secretion protein HlyD family protein
ISA75_RS11705	COG1120	ATPase activity
ISA75_RS11710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA75_RS11735	COG1473	amidohydrolase
ISA75_RS11740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA75_RS11745	COG0667	Aldo Keto reductase
ISA75_RS11775	COG4680	protein conserved in bacteria
ISA75_RS11790	COG0531	amino acid
ISA75_RS11800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISA75_RS11805	COG1012	belongs to the aldehyde dehydrogenase family
ISA75_RS11820	COG1113	amino acid transport
ISA75_RS11825	COG2211	Major facilitator Superfamily
ISA75_RS11835	COG0673	inositol 2-dehydrogenase activity
ISA75_RS11845	COG1609	Transcriptional regulator
ISA75_RS11850	COG0668	transmembrane transport
ISA75_RS11855	COG0477	Major facilitator Superfamily
ISA75_RS11870	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ISA75_RS11870	COG3933	PFAM sigma-54 factor interaction domain-containing protein
ISA75_RS11875	COG2222	sugar isomerase
ISA75_RS11880	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ISA75_RS11885	COG3716	PTS system mannose fructose sorbose family IID component
ISA75_RS11895	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA75_RS11905	COG0778	Nitroreductase
ISA75_RS11910	COG2315	Protein conserved in bacteria
ISA75_RS11950	COG3698	Phosphodiester glycosidase
ISA75_RS11960	COG4166	transmembrane transport
ISA75_RS11970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISA75_RS11975	COG4608	Belongs to the ABC transporter superfamily
ISA75_RS11990	COG0697	spore germination
ISA75_RS12005	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ISA75_RS12010	COG0765	amino acid transport
ISA75_RS12015	COG4215	(ABC) transporter
ISA75_RS12025	COG4221	oxidoreductase activity
ISA75_RS12030	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ISA75_RS12035	COG4608	Belongs to the ABC transporter superfamily
ISA75_RS12040	COG0444	Belongs to the ABC transporter superfamily
ISA75_RS12045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISA75_RS12050	COG0601	transmembrane transport
ISA75_RS12055	COG0747	negative chemotaxis
ISA75_RS12100	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ISA75_RS12110	COG0668	transmembrane transport
ISA75_RS12115	COG0583	DNA-binding transcription factor activity
ISA75_RS12125	COG1028	Short-chain dehydrogenase reductase Sdr
ISA75_RS12135	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA75_RS12140	COG1129	ABC transporter
ISA75_RS12150	COG1879	ABC-type sugar transport system periplasmic component
ISA75_RS12155	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ISA75_RS12160	COG2390	Transcriptional regulator
ISA75_RS12165	COG3959	Transketolase, thiamine diphosphate binding domain
ISA75_RS12170	COG3958	Transketolase
ISA75_RS12175	COG2977	Belongs to the P-Pant transferase superfamily
ISA75_RS12180	COG4771	TonB-dependent receptor
ISA75_RS12185	COG2382	esterase
ISA75_RS12190	COG3251	PFAM MbtH domain protein
ISA75_RS12195	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
ISA75_RS12195	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISA75_RS12210	COG1120	ATPase activity
ISA75_RS12215	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA75_RS12220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA75_RS12230	COG4592	Periplasmic binding protein
ISA75_RS12235	COG1169	isochorismate synthase
ISA75_RS12240	COG1021	2,3-dihydroxybenzoate-AMP ligase
ISA75_RS12245	COG1535	isochorismatase
ISA75_RS12245	COG3433	isochorismatase activity
ISA75_RS12250	COG1028	Short-chain dehydrogenase reductase Sdr
ISA75_RS12260	COG1966	Carbon starvation protein
ISA75_RS12265	COG2879	small protein
ISA75_RS12280	COG1028	Short-chain dehydrogenase reductase Sdr
ISA75_RS12285	COG0371	Dehydrogenase
ISA75_RS12290	COG1129	ABC transporter
ISA75_RS12295	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA75_RS12325	COG2271	Major facilitator Superfamily
ISA75_RS12330	COG0483	inositol monophosphate 1-phosphatase activity
ISA75_RS12340	COG0402	S-adenosylhomocysteine deaminase activity
ISA75_RS12350	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ISA75_RS12365	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISA75_RS12375	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA75_RS12380	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA75_RS12385	COG1129	ABC transporter
ISA75_RS12410	COG0436	Aminotransferase
ISA75_RS12415	COG1475	DNA binding
ISA75_RS12420	COG3969	phosphoadenosine phosphosulfate
ISA75_RS12425	COG0583	DNA-binding transcription factor activity
ISA75_RS12430	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISA75_RS12450	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISA75_RS12455	COG3719	Belongs to the RNase T2 family
ISA75_RS12460	COG3069	C4-dicarboxylate transmembrane transporter activity
ISA75_RS12480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISA75_RS12485	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ISA75_RS12495	COG0583	DNA-binding transcription factor activity
ISA75_RS12510	COG1686	Belongs to the peptidase S11 family
ISA75_RS12515	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ISA75_RS12520	COG0772	Belongs to the SEDS family
ISA75_RS12525	COG0768	penicillin binding
ISA75_RS12535	COG0799	negative regulation of ribosome biogenesis
ISA75_RS12550	COG1466	dna polymerase III delta subunit
ISA75_RS12565	COG2888	peptidyl-tyrosine sulfation
ISA75_RS12580	COG1126	abc transporter atp-binding protein
ISA75_RS12585	COG0765	amino acid transport
ISA75_RS12590	COG0765	amino acid transport
ISA75_RS12615	COG1702	phosphate starvation-inducible protein PhoH
ISA75_RS12625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISA75_RS12665	COG0367	asparagine synthase
ISA75_RS12670	COG0647	UMP catabolic process
ISA75_RS12675	COG1940	carbohydrate kinase activity
ISA75_RS12675	COG1846	Transcriptional regulator
ISA75_RS12680	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ISA75_RS12725	COG1053	succinate dehydrogenase
ISA75_RS12730	COG0583	DNA-binding transcription factor activity
ISA75_RS12735	COG0735	belongs to the Fur family
ISA75_RS12750	COG0596	Alpha beta hydrolase
ISA75_RS12760	COG0033	Phosphoglucomutase
ISA75_RS12770	COG0745	RESPONSE REGULATOR receiver
ISA75_RS12775	COG2205	protein histidine kinase activity
ISA75_RS12820	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ISA75_RS12825	COG1984	allophanate hydrolase subunit 2
ISA75_RS12850	COG2009	succinate dehydrogenase
ISA75_RS12855	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ISA75_RS12860	COG1053	succinate dehydrogenase
ISA75_RS12865	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ISA75_RS12870	COG0567	Dehydrogenase, E1 component
ISA75_RS12875	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISA75_RS12885	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ISA75_RS12890	COG1271	oxidase subunit
ISA75_RS12895	COG1294	oxidase, subunit
ISA75_RS12900	COG4890	Cyd operon protein YbgT
ISA75_RS12905	COG3790	cyd operon protein YbgE
ISA75_RS12910	COG0824	Thioesterase
ISA75_RS12915	COG0811	peptide transport
ISA75_RS12920	COG0848	biopolymer transport protein
ISA75_RS12925	COG3064	Membrane
ISA75_RS12935	COG2885	chlorophyll binding
ISA75_RS12940	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ISA75_RS12990	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ISA75_RS12995	COG3201	nicotinamide mononucleotide transporter
ISA75_RS13000	COG1230	cation diffusion facilitator family transporter
ISA75_RS13010	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISA75_RS13020	COG2017	converts alpha-aldose to the beta-anomer
ISA75_RS13030	COG1085	galactose-1-phosphate uridylyltransferase
ISA75_RS13040	COG1119	ATPase activity
ISA75_RS13045	COG2005	Transcriptional regulator
ISA75_RS13045	COG3585	molybdate ion transport
ISA75_RS13055	COG0725	ABC transporter, periplasmic molybdate-binding protein
ISA75_RS13060	COG4149	molybdate abc transporter
ISA75_RS13070	COG0561	phosphatase activity
ISA75_RS13095	COG2200	EAL domain
ISA75_RS13100	COG0789	Transcriptional regulator
ISA75_RS13130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA75_RS13135	COG0589	response to stress
ISA75_RS13145	COG4677	pectinesterase activity
ISA75_RS13185	COG1881	PFAM PEBP family protein
ISA75_RS13190	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ISA75_RS13205	COG2226	methyltransferase
ISA75_RS13230	COG0642	Histidine kinase
ISA75_RS13255	COG0521	Mo-molybdopterin cofactor biosynthetic process
ISA75_RS13265	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ISA75_RS13270	COG0314	molybdopterin synthase activity
ISA75_RS13275	COG0670	Belongs to the BI1 family
ISA75_RS13280	COG0392	lysyltransferase activity
ISA75_RS13285	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISA75_RS13290	COG3568	Endonuclease Exonuclease Phosphatase
ISA75_RS13300	COG0842	Transport permease protein
ISA75_RS13305	COG0842	Transport permease protein
ISA75_RS13310	COG1131	(ABC) transporter
ISA75_RS13315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA75_RS13320	COG1309	transcriptional regulator
ISA75_RS13325	COG0583	DNA-binding transcription factor activity
ISA75_RS13330	COG2271	Major facilitator Superfamily
ISA75_RS13335	COG1028	Short-chain dehydrogenase reductase Sdr
ISA75_RS13340	COG3959	Transketolase, thiamine diphosphate binding domain
ISA75_RS13345	COG3958	Transketolase
ISA75_RS13350	COG0513	Belongs to the DEAD box helicase family
ISA75_RS13355	COG1199	ATP-dependent helicase activity
ISA75_RS13360	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ISA75_RS13370	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ISA75_RS13380	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ISA75_RS13390	COG0668	transmembrane transport
ISA75_RS13395	COG1126	abc transporter atp-binding protein
ISA75_RS13400	COG0765	amino acid transport
ISA75_RS13405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA75_RS13420	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ISA75_RS13425	COG2194	sulfuric ester hydrolase activity
ISA75_RS13440	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ISA75_RS13445	COG0667	Aldo Keto reductase
ISA75_RS13450	COG2723	6-phospho-beta-galactosidase activity
ISA75_RS13455	COG2188	Transcriptional regulator
ISA75_RS13460	COG1376	ErfK ybiS ycfS ynhG family protein
ISA75_RS13470	COG0488	(ABC) transporter
ISA75_RS13480	COG2271	Major facilitator Superfamily
ISA75_RS13485	COG1609	Transcriptional regulator
ISA75_RS13495	COG0561	phosphatase activity
ISA75_RS13500	COG1882	Formate acetyltransferase
ISA75_RS13505	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ISA75_RS13510	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ISA75_RS13515	COG0303	'Molybdopterin
ISA75_RS13520	COG1446	asparaginase
ISA75_RS13530	COG0747	negative chemotaxis
ISA75_RS13565	COG2133	pyrroloquinoline quinone binding
ISA75_RS13570	COG0625	glutathione transferase activity
ISA75_RS13575	COG1686	Belongs to the peptidase S11 family
ISA75_RS13580	COG1349	DNA-binding transcription factor activity
ISA75_RS13585	COG0671	phosphoesterase, PA-phosphatase related
ISA75_RS13590	COG2814	Major facilitator Superfamily
ISA75_RS13595	COG0561	phosphatase activity
ISA75_RS13600	COG0738	Major facilitator superfamily
ISA75_RS13605	COG3226	Transcriptional regulator
ISA75_RS13630	COG0778	Nitroreductase
ISA75_RS13645	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ISA75_RS13650	COG3842	ATPase activity
ISA75_RS13655	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISA75_RS13660	COG1177	transmembrane transport
ISA75_RS13675	COG0745	RESPONSE REGULATOR receiver
ISA75_RS13680	COG5002	protein histidine kinase activity
ISA75_RS13685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA75_RS13690	COG4160	amino acid transport
ISA75_RS13695	COG4215	(ABC) transporter
ISA75_RS13700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA75_RS13705	COG1126	abc transporter atp-binding protein
ISA75_RS13725	COG3023	N-Acetylmuramoyl-L-alanine amidase
ISA75_RS13730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISA75_RS13735	COG0702	epimerase
ISA75_RS13740	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ISA75_RS13745	COG0028	Belongs to the TPP enzyme family
ISA75_RS13755	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISA75_RS13765	COG2431	L-lysine efflux transmembrane transporter activity
ISA75_RS13775	COG3593	DNA synthesis involved in DNA repair
ISA75_RS13780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA75_RS13790	COG1278	Cold shock
ISA75_RS13800	COG0542	response to heat
ISA75_RS13815	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ISA75_RS13820	COG4988	ABC transporter
ISA75_RS13825	COG0492	ferredoxin-NADP+ reductase activity
ISA75_RS13845	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ISA75_RS13855	COG0243	molybdopterin cofactor binding
ISA75_RS13860	COG0437	4 iron, 4 sulfur cluster binding
ISA75_RS13865	COG3302	dmso reductase anchor subunit
ISA75_RS13870	COG0477	Major facilitator Superfamily
ISA75_RS13875	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ISA75_RS13880	COG1882	Formate acetyltransferase
ISA75_RS13885	COG2116	formate transmembrane transporter activity
ISA75_RS13890	COG1944	ATP diphosphatase activity
ISA75_RS13895	COG2323	membrane
ISA75_RS13915	COG0539	negative regulation of cytoplasmic translation
ISA75_RS13925	COG0658	competence protein
ISA75_RS13925	COG2333	competence protein COMEC
ISA75_RS13940	COG3214	Protein conserved in bacteria
ISA75_RS13955	COG3173	Aminoglycoside phosphotransferase
ISA75_RS13960	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ISA75_RS13965	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ISA75_RS13975	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
ISA75_RS13985	COG2989	Protein conserved in bacteria
ISA75_RS13990	COG3108	Peptidase M15
ISA75_RS13995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISA75_RS14000	COG1448	Aminotransferase
ISA75_RS14005	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ISA75_RS14025	COG0814	amino acid
ISA75_RS14035	COG1473	amidohydrolase
ISA75_RS14040	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ISA75_RS14045	COG0308	aminopeptidase N
ISA75_RS14055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISA75_RS14060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISA75_RS14065	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISA75_RS14070	COG0431	NADPH-dependent FMN reductase
ISA75_RS14085	COG0633	Ferredoxin
ISA75_RS14085	COG3217	Mosc domain protein beta barrel domain protein
ISA75_RS14095	COG0488	(ABC) transporter
ISA75_RS14100	COG2995	paraquat-inducible protein a
ISA75_RS14105	COG3008	intermembrane lipid transfer
ISA75_RS14105	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISA75_RS14110	COG3009	Protein conserved in bacteria
ISA75_RS14115	COG3130	regulation of translation
ISA75_RS14125	COG1067	ATP-dependent peptidase activity
ISA75_RS14145	COG3070	regulator of competence-specific genes
ISA75_RS14150	COG1289	transmembrane transporter activity
ISA75_RS14155	COG3304	Inner membrane component domain
ISA75_RS14160	COG0210	DNA helicase
ISA75_RS14170	COG1832	CoA-binding protein
ISA75_RS14185	COG1881	PFAM PEBP family protein
ISA75_RS14190	COG2207	Transcriptional regulator
ISA75_RS14205	COG0670	Belongs to the BI1 family
ISA75_RS14225	COG0058	SHG alpha-glucan phosphorylase activity
ISA75_RS14235	COG2200	EAL domain
ISA75_RS14255	COG3706	GGDEF domain
ISA75_RS14270	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISA75_RS14275	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ISA75_RS14280	COG1882	Formate acetyltransferase
ISA75_RS14285	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISA75_RS14290	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISA75_RS14295	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA75_RS14295	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA75_RS14295	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISA75_RS14300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISA75_RS14305	COG1012	belongs to the aldehyde dehydrogenase family
ISA75_RS14310	COG4638	Rieske (2fe-2S)
ISA75_RS14325	COG0473	3-isopropylmalate dehydrogenase activity
ISA75_RS14330	COG0583	DNA-binding transcription factor activity
ISA75_RS14335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISA75_RS14340	COG1012	belongs to the aldehyde dehydrogenase family
ISA75_RS14345	COG1396	sequence-specific DNA binding
ISA75_RS14345	COG1917	Cupin 2, conserved barrel domain protein
ISA75_RS14350	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ISA75_RS14355	COG0174	glutamine synthetase
ISA75_RS14360	COG0531	amino acid
ISA75_RS14375	COG1028	Short-chain dehydrogenase reductase Sdr
ISA75_RS14405	COG3729	General stress protein
ISA75_RS14415	COG2233	PERMEase
ISA75_RS14450	COG1309	transcriptional regulator
ISA75_RS14465	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ISA75_RS14475	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISA75_RS14495	COG1702	phosphate starvation-inducible protein PhoH
ISA75_RS14505	COG1335	isochorismatase
ISA75_RS14515	COG0583	DNA-binding transcription factor activity
ISA75_RS14520	COG1309	transcriptional regulator
ISA75_RS14550	COG3311	Transcriptional regulator
ISA75_RS14760	COG3381	protein complex oligomerization
ISA75_RS14795	COG5645	(Lipo)protein
ISA75_RS14810	COG1560	Kdo2-lipid A biosynthetic process
ISA75_RS14855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISA75_RS14875	COG2814	Major facilitator Superfamily
ISA75_RS14880	COG0583	DNA-binding transcription factor activity
ISA75_RS14885	COG1530	ribonuclease E activity
ISA75_RS14900	COG0424	maF-like protein
ISA75_RS14905	COG1399	metal-binding, possibly nucleic acid-binding protein
ISA75_RS14925	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ISA75_RS14940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISA75_RS14945	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISA75_RS14950	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ISA75_RS14960	COG0470	DNA polymerase III
ISA75_RS14965	COG0084	hydrolase, TatD family'
ISA75_RS14975	COG0537	adenosine 5'-monophosphoramidase activity
ISA75_RS14980	COG5633	Lipoprotein
ISA75_RS15005	COG1252	NADH dehydrogenase
ISA75_RS15010	COG3134	Outer membrane lipoprotein
ISA75_RS15025	COG1309	transcriptional regulator
ISA75_RS15040	COG1376	ErfK ybiS ycfS ynhG family protein
ISA75_RS15040	COG1388	LysM domain
ISA75_RS15045	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ISA75_RS15055	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISA75_RS15065	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISA75_RS15075	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ISA75_RS15085	COG2390	Transcriptional regulator
ISA75_RS15100	COG3395	kinase activity
ISA75_RS15115	COG0698	ribose 5-phosphate isomerase
ISA75_RS15120	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISA75_RS15125	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ISA75_RS15130	COG0318	PFAM AMP-dependent synthetase and ligase
ISA75_RS15145	COG1177	transmembrane transport
ISA75_RS15165	COG2850	peptidyl-arginine hydroxylation
ISA75_RS15170	COG2205	protein histidine kinase activity
ISA75_RS15190	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ISA75_RS15210	COG1187	pseudouridine synthase activity
ISA75_RS15215	COG0538	isocitrate dehydrogenase activity
ISA75_RS15220	COG0582	viral genome integration into host DNA
ISA75_RS15240	COG3706	GGDEF domain
ISA75_RS15250	COG0538	isocitrate dehydrogenase activity
ISA75_RS15265	COG0640	Transcriptional regulator
ISA75_RS15290	COG3813	Protein conserved in bacteria
ISA75_RS15295	COG1063	alcohol dehydrogenase
ISA75_RS15300	COG3729	General stress protein
ISA75_RS15305	COG3685	Protein conserved in bacteria
ISA75_RS15310	COG3685	Protein conserved in bacteria
ISA75_RS15315	COG3546	catalase activity
ISA75_RS15320	COG1271	oxidase subunit
ISA75_RS15325	COG1294	oxidase, subunit
ISA75_RS15330	COG1566	PFAM secretion protein HlyD family protein
ISA75_RS15345	COG2207	Transcriptional regulator
ISA75_RS15375	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ISA75_RS15380	COG0583	DNA-binding transcription factor activity
ISA75_RS15385	COG3706	GGDEF domain
ISA75_RS15390	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ISA75_RS15400	COG1560	Kdo2-lipid A biosynthetic process
ISA75_RS15410	COG3182	Iron-regulated membrane protein
ISA75_RS15430	COG2203	Gaf domain
ISA75_RS15430	COG2199	diguanylate cyclase activity
ISA75_RS15435	COG3042	response to heat
ISA75_RS15440	COG3189	MarR family transcriptional regulator
ISA75_RS15445	COG1683	Conserved Protein
ISA75_RS15450	COG0504	CTP synthase activity
ISA75_RS15455	COG2807	transmembrane transport
ISA75_RS15460	COG2207	Transcriptional regulator
ISA75_RS15470	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ISA75_RS15475	COG0859	PFAM glycosyl transferase family 9
ISA75_RS15495	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ISA75_RS15505	COG0436	Aminotransferase
ISA75_RS15515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISA75_RS15520	COG0006	proline dipeptidase activity
ISA75_RS15525	COG4948	Mandelate Racemase Muconate Lactonizing
ISA75_RS15530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISA75_RS15535	COG1126	abc transporter atp-binding protein
ISA75_RS15540	COG0765	amino acid transport
ISA75_RS15545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA75_RS15580	COG1283	sodium-dependent phosphate transmembrane transporter activity
ISA75_RS15600	COG0583	DNA-binding transcription factor activity
ISA75_RS15605	COG1028	Short-chain dehydrogenase reductase Sdr
ISA75_RS15615	COG1902	pentaerythritol trinitrate reductase activity
ISA75_RS15620	COG0583	DNA-binding transcription factor activity
ISA75_RS15625	COG0300	oxidoreductase activity
ISA75_RS15640	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ISA75_RS15650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA75_RS15655	COG0765	amino acid transport
ISA75_RS15660	COG1126	abc transporter atp-binding protein
ISA75_RS15695	COG0386	Belongs to the glutathione peroxidase family
ISA75_RS15710	COG2766	serine protein kinase
ISA75_RS15715	COG3713	MltA-interacting MipA family protein
ISA75_RS15720	COG0656	L-ascorbic acid biosynthetic process
ISA75_RS15740	COG3139	Protein of unknown function (DUF1315)
ISA75_RS15755	COG1335	isochorismatase
ISA75_RS15760	COG0252	asparaginase activity
ISA75_RS15765	COG0616	signal peptide processing
ISA75_RS15770	COG0778	Nitroreductase
ISA75_RS15780	COG0709	Synthesizes selenophosphate from selenide and ATP
ISA75_RS15785	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ISA75_RS15790	COG0604	alcohol dehydrogenase
ISA75_RS15790	COG1028	Short-chain dehydrogenase reductase Sdr
ISA75_RS15790	COG3321	synthase
ISA75_RS15795	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ISA75_RS15800	COG0494	nUDIX hydrolase
ISA75_RS15805	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ISA75_RS15810	COG2897	thiosulfate sulfurtransferase activity
ISA75_RS15815	COG4136	ATPase activity
ISA75_RS15820	COG4135	transport system, permease component
ISA75_RS15825	COG4134	Bacterial extracellular solute-binding protein
ISA75_RS15830	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISA75_RS15835	COG0398	Pfam SNARE associated Golgi protein
ISA75_RS15840	COG0398	Pfam SNARE associated Golgi protein
ISA75_RS15845	COG0708	Exodeoxyribonuclease III
ISA75_RS15855	COG3138	arginine N-succinyltransferase
ISA75_RS15865	COG3724	N-succinylarginine dihydrolase activity
ISA75_RS15875	COG3678	ATP-independent chaperone mediated protein folding
ISA75_RS15880	COG0322	excinuclease ABC activity
ISA75_RS15890	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISA75_RS15895	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA75_RS15905	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA75_RS15910	COG1447	Phosphotransferase system cellobiose-specific component IIA
ISA75_RS15915	COG1917	Cupin 2, conserved barrel domain protein
ISA75_RS15915	COG2169	Transcriptional regulator
ISA75_RS15920	COG1486	melibiose metabolic process
ISA75_RS15930	COG0753	catalase activity
ISA75_RS15940	COG1823	symporter activity
ISA75_RS15945	COG1988	membrane-bound metal-dependent
ISA75_RS15950	COG1028	Short-chain dehydrogenase reductase Sdr
ISA75_RS15955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISA75_RS15985	COG0727	PFAM Uncharacterised protein family (UPF0153)
ISA75_RS15990	COG3047	cAMP biosynthetic process
ISA75_RS16000	COG4774	siderophore transport
ISA75_RS16045	COG0135	phosphoribosylanthranilate isomerase activity
ISA75_RS16045	COG0134	indole-3-glycerol-phosphate synthase activity
ISA75_RS16050	COG0512	Glutamine amidotransferase of anthranilate synthase
ISA75_RS16050	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ISA75_RS16055	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ISA75_RS16065	COG0009	L-threonylcarbamoyladenylate synthase
ISA75_RS16080	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
ISA75_RS16085	COG1028	Short-chain dehydrogenase reductase Sdr
ISA75_RS16090	COG0616	signal peptide processing
ISA75_RS16115	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ISA75_RS16125	COG0671	phosphoesterase, PA-phosphatase related
ISA75_RS16130	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ISA75_RS16135	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ISA75_RS16145	COG0023	Translation Initiation Factor
ISA75_RS16155	COG1349	DNA-binding transcription factor activity
ISA75_RS16170	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISA75_RS16170	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISA75_RS16175	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ISA75_RS16205	COG2986	histidine ammonia-lyase
ISA75_RS16220	COG4171	peptide transport system, permease
ISA75_RS16235	COG0702	epimerase
ISA75_RS16250	COG1473	amidohydrolase
ISA75_RS16260	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ISA75_RS16265	COG1842	Phage shock protein A
ISA75_RS16275	COG1983	PspC domain protein
ISA75_RS16285	COG3106	COG3106 Predicted ATPase
ISA75_RS16300	COG3180	Ammonia monooxygenase
ISA75_RS16305	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ISA75_RS16310	COG4948	Mandelate Racemase Muconate Lactonizing
ISA75_RS16315	COG2866	Carboxypeptidase
ISA75_RS16325	COG4166	transmembrane transport
ISA75_RS16335	COG0765	amino acid transport
ISA75_RS16345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA75_RS16350	COG0583	DNA-binding transcription factor activity
ISA75_RS16355	COG0583	DNA-binding transcription factor activity
ISA75_RS16360	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISA75_RS16400	COG0656	L-ascorbic acid biosynthetic process
ISA75_RS16405	COG3250	beta-galactosidase activity
ISA75_RS16470	COG0583	DNA-binding transcription factor activity
ISA75_RS16475	COG1028	Short-chain dehydrogenase reductase Sdr
ISA75_RS16480	COG0693	protein deglycase activity
ISA75_RS16505	COG2885	chlorophyll binding
ISA75_RS16595	COG1028	Short-chain dehydrogenase reductase Sdr
ISA75_RS16600	COG1309	transcriptional regulator
ISA75_RS16605	COG1028	Short-chain dehydrogenase reductase Sdr
ISA75_RS16625	COG0583	DNA-binding transcription factor activity
ISA75_RS16655	COG0604	alcohol dehydrogenase
ISA75_RS16660	COG0436	Aminotransferase
ISA75_RS16665	COG1464	Belongs to the NlpA lipoprotein family
ISA75_RS16675	COG2011	ABC-type metal ion transport system permease component
ISA75_RS16680	COG1448	Aminotransferase
ISA75_RS16690	COG1522	sequence-specific DNA binding
ISA75_RS16695	COG1113	amino acid transport
ISA75_RS16710	COG0673	inositol 2-dehydrogenase activity
ISA75_RS16715	COG1349	DNA-binding transcription factor activity
ISA75_RS16725	COG0513	Belongs to the DEAD box helicase family
ISA75_RS16735	COG0582	viral genome integration into host DNA
ISA75_RS16755	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISA75_RS16795	COG1484	DNA-dependent DNA replication
ISA75_RS16840	COG0456	acetyltransferase
ISA75_RS16875	COG0484	heat shock protein binding
ISA75_RS16890	COG3772	lysozyme
ISA75_RS16930	COG5484	DNA packaging
ISA75_RS16930	COG3728	DNA packaging
ISA75_RS17020	COG1196	nuclear chromosome segregation
ISA75_RS17080	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ISA75_RS17085	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ISA75_RS17090	COG1028	Short-chain dehydrogenase reductase Sdr
ISA75_RS17095	COG1280	lysine exporter protein (LysE YggA)
ISA75_RS17105	COG0583	DNA-binding transcription factor activity
ISA75_RS17115	COG2135	peptidase activity
ISA75_RS17120	COG0589	response to stress
ISA75_RS17130	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ISA75_RS17135	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISA75_RS17135	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ISA75_RS17135	COG1013	pyruvate-flavodoxin oxidoreductase activity
ISA75_RS17135	COG0674	pyruvate-flavodoxin oxidoreductase activity
ISA75_RS17140	COG3042	response to heat
ISA75_RS17145	COG3187	Heat shock protein
ISA75_RS17150	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ISA75_RS17155	COG0586	Pfam SNARE associated Golgi protein
ISA75_RS17160	COG2911	Protein conserved in bacteria
ISA75_RS17170	COG3784	Protein of unknown function (DUF1318)
ISA75_RS17175	COG2207	Transcriptional regulator
ISA75_RS17180	COG1012	belongs to the aldehyde dehydrogenase family
ISA75_RS17195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA75_RS17205	COG1126	abc transporter atp-binding protein
ISA75_RS17210	COG0583	DNA-binding transcription factor activity
ISA75_RS17215	COG2072	flavoprotein involved in K transport
ISA75_RS17230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISA75_RS17250	COG2030	dehydratase
ISA75_RS17250	COG1012	belongs to the aldehyde dehydrogenase family
ISA75_RS17255	COG3396	Phenylacetate-CoA oxygenase
ISA75_RS17260	COG3460	Phenylacetate-CoA oxygenase
ISA75_RS17265	COG3396	Phenylacetate-CoA oxygenase
ISA75_RS17270	COG2151	metal-sulfur cluster biosynthetic enzyme
ISA75_RS17275	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISA75_RS17280	COG1024	Enoyl-CoA hydratase
ISA75_RS17285	COG1024	Enoyl-CoA hydratase
ISA75_RS17290	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISA75_RS17295	COG2050	protein possibly involved in aromatic compounds catabolism
ISA75_RS17300	COG0183	Belongs to the thiolase family
ISA75_RS17305	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
ISA75_RS17310	COG3327	negative regulation of DNA-templated transcription, initiation
ISA75_RS17315	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ISA75_RS17325	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
ISA75_RS17335	COG1643	Atp-dependent helicase
ISA75_RS17345	COG4122	O-methyltransferase activity
ISA75_RS17370	COG0583	DNA-binding transcription factor activity
ISA75_RS17375	COG0667	Aldo Keto reductase
ISA75_RS17380	COG2814	Major facilitator Superfamily
ISA75_RS17385	COG0667	Aldo Keto reductase
ISA75_RS17395	COG0183	Belongs to the thiolase family
ISA75_RS17410	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ISA75_RS17420	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISA75_RS17425	COG3138	arginine N-succinyltransferase
ISA75_RS17430	COG1012	belongs to the aldehyde dehydrogenase family
ISA75_RS17435	COG3724	N-succinylarginine dihydrolase activity
ISA75_RS17440	COG2988	succinylglutamate desuccinylase activity
ISA75_RS17445	COG1113	amino acid transport
ISA75_RS17450	COG0477	Major facilitator Superfamily
ISA75_RS17455	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ISA75_RS17465	COG1012	belongs to the aldehyde dehydrogenase family
ISA75_RS17470	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ISA75_RS17475	COG0401	homolog of Blt101
ISA75_RS17480	COG5562	phage envelope protein
ISA75_RS17485	COG0425	Belongs to the sulfur carrier protein TusA family
ISA75_RS17515	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ISA75_RS17520	COG1263	PTS System
ISA75_RS17520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA75_RS17525	COG1609	Transcriptional regulator
ISA75_RS17530	COG5339	Protein conserved in bacteria
ISA75_RS17535	COG1482	cell wall glycoprotein biosynthetic process
ISA75_RS17540	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ISA75_RS17540	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ISA75_RS17545	COG0114	fumarate hydratase activity
ISA75_RS17555	COG2205	protein histidine kinase activity
ISA75_RS17560	COG1028	Short-chain dehydrogenase reductase Sdr
ISA75_RS17570	COG0745	RESPONSE REGULATOR receiver
ISA75_RS17575	COG3136	membrane protein required for alginate biosynthesis
ISA75_RS17585	COG0531	amino acid
ISA75_RS17600	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ISA75_RS17605	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ISA75_RS17620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISA75_RS17635	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ISA75_RS17640	COG1473	amidohydrolase
ISA75_RS17650	COG0583	DNA-binding transcription factor activity
ISA75_RS17655	COG2840	Smr protein MutS2
ISA75_RS17660	COG1414	Transcriptional regulator
ISA75_RS17670	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ISA75_RS17675	COG0183	Belongs to the thiolase family
ISA75_RS17685	COG0596	Alpha beta hydrolase
ISA75_RS17690	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISA75_RS17700	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ISA75_RS17700	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ISA75_RS17720	COG4565	transcriptional regulatory protein
ISA75_RS17725	COG3290	protein histidine kinase activity
ISA75_RS17740	COG2814	Major facilitator Superfamily
ISA75_RS17750	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ISA75_RS17760	COG0679	Auxin Efflux Carrier
ISA75_RS17790	COG0628	permease
ISA75_RS17810	COG3591	Belongs to the peptidase S1B family
ISA75_RS17825	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ISA75_RS17830	COG2814	Major facilitator Superfamily
ISA75_RS17835	COG0583	DNA-binding transcription factor activity
ISA75_RS17840	COG1940	carbohydrate kinase activity
ISA75_RS17845	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ISA75_RS17860	COG3302	dmso reductase anchor subunit
ISA75_RS17865	COG0437	4 iron, 4 sulfur cluster binding
ISA75_RS17870	COG0243	molybdopterin cofactor binding
ISA75_RS17885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISA75_RS17900	COG2271	Major facilitator Superfamily
ISA75_RS17905	COG0246	Mannitol dehydrogenase
ISA75_RS17910	COG0589	response to stress
ISA75_RS17915	COG1802	Transcriptional regulator
ISA75_RS17920	COG4221	oxidoreductase activity
ISA75_RS17935	COG0583	DNA-binding transcription factor activity
ISA75_RS17940	COG0406	alpha-ribazole phosphatase activity
ISA75_RS17950	COG0583	DNA-binding transcription factor activity
ISA75_RS18005	COG0071	Belongs to the small heat shock protein (HSP20) family
ISA75_RS18010	COG1546	Belongs to the CinA family
ISA75_RS18015	COG2200	EAL domain
ISA75_RS18030	COG2207	Transcriptional regulator
ISA75_RS18030	COG3708	Transcriptional regulator
ISA75_RS18035	COG2610	gluconate transmembrane transporter activity
ISA75_RS18040	COG3622	Belongs to the hyi family
ISA75_RS18045	COG0235	Class ii aldolase
ISA75_RS18050	COG3395	kinase activity
ISA75_RS18055	COG2084	Dehydrogenase
ISA75_RS18060	COG1349	DNA-binding transcription factor activity
ISA75_RS18075	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ISA75_RS18080	COG2223	nitrite transmembrane transporter activity
ISA75_RS18115	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ISA75_RS18120	COG0683	leucine binding
ISA75_RS18150	COG2814	Major facilitator Superfamily
ISA75_RS18155	COG0697	spore germination
ISA75_RS18165	COG4977	sequence-specific DNA binding
ISA75_RS18190	COG1028	Short-chain dehydrogenase reductase Sdr
ISA75_RS18195	COG2731	YhcH YjgK YiaL family protein
ISA75_RS18210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISA75_RS18220	COG3395	kinase activity
ISA75_RS18225	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ISA75_RS18230	COG1349	DNA-binding transcription factor activity
ISA75_RS18235	COG0039	L-malate dehydrogenase activity
ISA75_RS18245	COG0583	DNA-binding transcription factor activity
ISA75_RS18250	COG1012	belongs to the aldehyde dehydrogenase family
ISA75_RS18265	COG2199	diguanylate cyclase activity
ISA75_RS18340	COG0477	Major facilitator Superfamily
ISA75_RS18350	COG2070	2-Nitropropane dioxygenase
ISA75_RS18355	COG2011	ABC-type metal ion transport system permease component
ISA75_RS18375	COG4628	conserved protein (DUF2132)
ISA75_RS18390	COG2207	Transcriptional regulator
ISA75_RS18420	COG2233	PERMEase
ISA75_RS18430	COG2351	hydroxyisourate hydrolase activity
ISA75_RS18435	COG1396	sequence-specific DNA binding
ISA75_RS18440	COG3550	peptidyl-serine autophosphorylation
ISA75_RS18445	COG1649	PFAM Uncharacterised BCR, COG1649
ISA75_RS18455	COG3188	usher protein
ISA75_RS18490	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ISA75_RS18510	COG5001	Diguanylate cyclase
ISA75_RS18510	COG3300	MHYT domain
ISA75_RS18515	COG2819	hydrolase of the alpha beta superfamily
ISA75_RS18530	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA75_RS18530	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA75_RS18535	COG2814	Major facilitator Superfamily
ISA75_RS18545	COG1263	PTS System
ISA75_RS18545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA75_RS18550	COG2186	Transcriptional regulator
ISA75_RS18635	COG3850	Histidine kinase
ISA75_RS18635	COG5002	protein histidine kinase activity
ISA75_RS18665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISA75_RS18670	COG0601	transmembrane transport
ISA75_RS18675	COG0747	negative chemotaxis
ISA75_RS18700	COG1609	Transcriptional regulator
ISA75_RS18710	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA75_RS18725	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISA75_RS18735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISA75_RS18740	COG0583	DNA-binding transcription factor activity
ISA75_RS18745	COG0583	DNA-binding transcription factor activity
ISA75_RS18765	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISA75_RS18775	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ISA75_RS18780	COG3037	sugar-specific permease SgaT UlaA
ISA75_RS18790	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA75_RS18795	COG1609	Transcriptional regulator
ISA75_RS18800	COG0583	DNA-binding transcription factor activity
ISA75_RS18805	COG1028	Short-chain dehydrogenase reductase Sdr
ISA75_RS18820	COG0439	Biotin carboxylase
ISA75_RS18825	COG3665	Urea carboxylase-associated protein
ISA75_RS18835	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ISA75_RS18850	COG2223	nitrite transmembrane transporter activity
ISA75_RS18880	COG0477	Major facilitator Superfamily
ISA75_RS18885	COG4529	Protein conserved in bacteria
ISA75_RS18890	COG1902	pentaerythritol trinitrate reductase activity
ISA75_RS18900	COG0583	DNA-binding transcription factor activity
ISA75_RS18905	COG2070	2-Nitropropane dioxygenase
ISA75_RS18915	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISA75_RS18925	COG0765	amino acid transport
ISA75_RS18995	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISA75_RS19010	COG0583	DNA-binding transcription factor activity
ISA75_RS19015	COG3711	transcriptional antiterminator
ISA75_RS19020	COG2723	6-phospho-beta-galactosidase activity
ISA75_RS19025	COG1263	PTS System
ISA75_RS19025	COG2190	(PTS) system
ISA75_RS19025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA75_RS19045	COG0583	DNA-binding transcription factor activity
ISA75_RS19060	COG2207	Transcriptional regulator
ISA75_RS19070	COG1280	lysine exporter protein (LysE YggA)
ISA75_RS19105	COG1953	Uracil, thiamine, allantoin
ISA75_RS19110	COG0402	S-adenosylhomocysteine deaminase activity
ISA75_RS19120	COG3706	GGDEF domain
ISA75_RS19125	COG1609	Transcriptional regulator
ISA75_RS19135	COG0673	inositol 2-dehydrogenase activity
ISA75_RS19155	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ISA75_RS19160	COG1116	anion transmembrane transporter activity
ISA75_RS19165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISA75_RS19170	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISA75_RS19175	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISA75_RS19180	COG0076	glutamate decarboxylase activity
ISA75_RS19195	COG2205	protein histidine kinase activity
ISA75_RS19205	COG0596	Alpha beta hydrolase
ISA75_RS19245	COG0519	Catalyzes the synthesis of GMP from XMP
ISA75_RS19245	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ISA75_RS19265	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ISA75_RS19270	COG2814	Major facilitator Superfamily
ISA75_RS19275	COG0583	DNA-binding transcription factor activity
ISA75_RS19280	COG0243	molybdopterin cofactor binding
ISA75_RS19285	COG3781	membrane
ISA75_RS19290	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ISA75_RS19305	COG1764	response to oxidative stress
ISA75_RS19315	COG3111	PFAM Bacterial OB fold (BOF) protein
ISA75_RS19325	COG2323	membrane
ISA75_RS19335	COG0366	Alpha amylase catalytic
ISA75_RS19345	COG3685	Protein conserved in bacteria
ISA75_RS19355	COG3729	General stress protein
ISA75_RS19360	COG1028	Short-chain dehydrogenase reductase Sdr
ISA75_RS19400	COG0488	(ABC) transporter
ISA75_RS19415	COG1064	alcohol dehydrogenase
ISA75_RS19420	COG0747	negative chemotaxis
ISA75_RS19425	COG0601	transmembrane transport
ISA75_RS19430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISA75_RS19440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISA75_RS19450	COG2814	Major facilitator Superfamily
ISA75_RS19460	COG2326	polyphosphate kinase activity
ISA75_RS19475	COG2864	formate dehydrogenase
ISA75_RS19480	COG0437	4 iron, 4 sulfur cluster binding
ISA75_RS19505	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
ISA75_RS19515	COG3485	protocatechuate 3,4-dioxygenase
ISA75_RS19520	COG4829	muconolactone delta-isomerase
ISA75_RS19525	COG4948	Mandelate Racemase Muconate Lactonizing
ISA75_RS19530	COG1414	Transcriptional regulator
ISA75_RS19545	COG2162	N-hydroxyarylamine O-acetyltransferase activity
ISA75_RS19550	COG1178	ABC-type Fe3 transport system permease component
ISA75_RS19555	COG1840	ABC-type Fe3 transport system, periplasmic component
ISA75_RS19560	COG3842	ATPase activity
ISA75_RS19565	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ISA75_RS19580	COG2211	Major facilitator Superfamily
ISA75_RS19595	COG0625	glutathione transferase activity
ISA75_RS19600	COG1609	Transcriptional regulator
ISA75_RS19610	COG2271	Major facilitator Superfamily
ISA75_RS19620	COG1126	abc transporter atp-binding protein
ISA75_RS19625	COG0765	amino acid transport
ISA75_RS19635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA75_RS19640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISA75_RS19645	COG1473	amidohydrolase
ISA75_RS19650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISA75_RS19655	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ISA75_RS19660	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ISA75_RS19665	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ISA75_RS19690	COG4772	TonB-dependent receptor
ISA75_RS19695	COG3691	Protein conserved in bacteria
ISA75_RS19710	COG2130	NADP-dependent
ISA75_RS19720	COG1247	-acetyltransferase
ISA75_RS19725	COG3238	Protein conserved in bacteria
ISA75_RS19735	COG0747	negative chemotaxis
ISA75_RS19740	COG1012	belongs to the aldehyde dehydrogenase family
ISA75_RS19770	COG1012	belongs to the aldehyde dehydrogenase family
ISA75_RS19775	COG1177	transmembrane transport
ISA75_RS19780	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISA75_RS19785	COG3842	ATPase activity
ISA75_RS19790	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ISA75_RS19795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISA75_RS19800	COG1271	oxidase subunit
ISA75_RS19805	COG1294	oxidase, subunit
ISA75_RS19825	COG0826	peptidase U32
ISA75_RS19835	COG1396	sequence-specific DNA binding
ISA75_RS19840	COG3135	benzoate transporter
ISA75_RS19845	COG3708	Transcriptional regulator
ISA75_RS19845	COG2207	Transcriptional regulator
ISA75_RS19850	COG0697	spore germination
ISA75_RS19860	COG0500	methyltransferase
ISA75_RS19865	COG1275	C4-dicarboxylate transporter malic acid transport protein
ISA75_RS19870	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ISA75_RS19875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISA75_RS19890	COG2272	Belongs to the type-B carboxylesterase lipase family
ISA75_RS19895	COG5383	Protein conserved in bacteria
ISA75_RS19900	COG3485	protocatechuate 3,4-dioxygenase
ISA75_RS19905	COG3485	protocatechuate 3,4-dioxygenase
ISA75_RS19910	COG0583	DNA-binding transcription factor activity
ISA75_RS19930	COG3038	cytochrome b561
ISA75_RS19950	COG2814	Major facilitator Superfamily
ISA75_RS19960	COG0673	inositol 2-dehydrogenase activity
ISA75_RS19970	COG2723	6-phospho-beta-galactosidase activity
ISA75_RS20005	COG4659	FMN binding
ISA75_RS20015	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ISA75_RS20025	COG0625	glutathione transferase activity
ISA75_RS20030	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
ISA75_RS20045	COG3895	Periplasmic Protein
ISA75_RS20075	COG1566	PFAM secretion protein HlyD family protein
ISA75_RS20080	COG1289	transmembrane transporter activity
ISA75_RS20085	COG2032	superoxide dismutase activity
ISA75_RS20090	COG4989	oxidoreductase activity
ISA75_RS20095	COG3313	Fe-S protein
ISA75_RS20100	COG1309	transcriptional regulator
ISA75_RS20105	COG1902	pentaerythritol trinitrate reductase activity
ISA75_RS20110	COG0346	lactoylglutathione lyase activity
ISA75_RS20120	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ISA75_RS20125	COG0791	NLP P60 protein
ISA75_RS20130	COG2207	Transcriptional regulator
ISA75_RS20140	COG2814	Major facilitator Superfamily
ISA75_RS20155	COG0583	DNA-binding transcription factor activity
ISA75_RS20160	COG2814	Major facilitator Superfamily
ISA75_RS20165	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ISA75_RS20170	COG0307	riboflavin synthase, alpha
ISA75_RS20210	COG0300	oxidoreductase activity
ISA75_RS20230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISA75_RS20270	COG1349	DNA-binding transcription factor activity
ISA75_RS20275	COG0346	lactoylglutathione lyase activity
ISA75_RS20290	COG2011	ABC-type metal ion transport system permease component
ISA75_RS20320	COG0444	Belongs to the ABC transporter superfamily
ISA75_RS20325	COG4608	Belongs to the ABC transporter superfamily
ISA75_RS20350	COG0583	DNA-binding transcription factor activity
ISA75_RS20355	COG0531	amino acid
ISA75_RS20360	COG1028	Short-chain dehydrogenase reductase Sdr
ISA75_RS20370	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISA75_RS20405	COG0402	S-adenosylhomocysteine deaminase activity
ISA75_RS20430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISA75_RS20435	COG0277	FAD linked oxidase domain protein
ISA75_RS20455	COG2814	Major facilitator Superfamily
ISA75_RS20485	COG0583	DNA-binding transcription factor activity
ISA75_RS20495	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ISA75_RS20505	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISA75_RS20510	COG2610	gluconate transmembrane transporter activity
ISA75_RS20515	COG1028	Short-chain dehydrogenase reductase Sdr
ISA75_RS20545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISA75_RS20560	COG0745	RESPONSE REGULATOR receiver
ISA75_RS20565	COG3850	Histidine kinase
ISA75_RS20565	COG5002	protein histidine kinase activity
ISA75_RS20580	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ISA75_RS20610	COG3088	subunit of a heme lyase
ISA75_RS20610	COG4235	cytochrome complex assembly
ISA75_RS20615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISA75_RS20620	COG1138	Cytochrome C-type biogenesis protein
ISA75_RS20635	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISA75_RS20640	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISA75_RS20645	COG4133	protoheme IX ABC transporter activity
ISA75_RS20675	COG1175	transmembrane transport
ISA75_RS20685	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
ISA75_RS20690	COG3383	formate dehydrogenase (NAD+) activity
ISA75_RS20715	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISA75_RS20715	COG1017	nitric oxide dioxygenase activity
ISA75_RS20725	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISA75_RS20730	COG2814	Major facilitator Superfamily
ISA75_RS20745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA75_RS20750	COG1121	(ABC) transporter
ISA75_RS20760	COG0346	lactoylglutathione lyase activity
ISA75_RS20780	COG1116	anion transmembrane transporter activity
ISA75_RS20790	COG3119	arylsulfatase activity
ISA75_RS20795	COG0641	radical SAM
ISA75_RS20820	COG1126	abc transporter atp-binding protein
ISA75_RS20825	COG0765	amino acid transport
ISA75_RS20845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA75_RS20850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA75_RS20855	COG1120	ATPase activity
ISA75_RS20860	COG4774	siderophore transport
ISA75_RS20865	COG1116	anion transmembrane transporter activity
ISA75_RS20870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISA75_RS20890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISA75_RS20895	COG0583	DNA-binding transcription factor activity
ISA75_RS20915	COG2814	Major facilitator Superfamily
ISA75_RS20950	COG1414	Transcriptional regulator
ISA75_RS20955	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISA75_RS20960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA75_RS20965	COG1120	ATPase activity
ISA75_RS20975	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ISA75_RS20980	COG2271	Major facilitator Superfamily
ISA75_RS20985	COG3185	4-Hydroxyphenylpyruvate dioxygenase
ISA75_RS20985	COG1082	Xylose isomerase domain protein TIM barrel
ISA75_RS20990	COG1309	transcriptional regulator
ISA75_RS21015	COG1376	ErfK ybiS ycfS ynhG family protein
ISA75_RS21030	COG0719	Fe-S assembly protein
ISA75_RS21035	COG0396	ATPase activity
ISA75_RS21040	COG0719	Fe-S assembly protein
ISA75_RS21045	COG0316	Belongs to the HesB IscA family
ISA75_RS21055	COG1304	FMN binding
ISA75_RS21080	COG0583	DNA-binding transcription factor activity
ISA75_RS21090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA75_RS21095	COG1120	ATPase activity
ISA75_RS21120	COG2261	transglycosylase associated protein
ISA75_RS21125	COG2050	protein possibly involved in aromatic compounds catabolism
ISA75_RS21130	COG0277	FAD linked oxidase domain protein
ISA75_RS21130	COG0247	lactate metabolic process
ISA75_RS21135	COG0628	permease
ISA75_RS21145	COG0574	Belongs to the PEP-utilizing enzyme family
ISA75_RS21145	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISA75_RS21160	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISA75_RS21165	COG4256	Hemin uptake protein
ISA75_RS21175	COG0791	NLP P60 protein
ISA75_RS21185	COG0386	Belongs to the glutathione peroxidase family
ISA75_RS21205	COG0583	DNA-binding transcription factor activity
ISA75_RS21215	COG0251	oxidation-reduction process
ISA75_RS21225	COG0072	phenylalanine-tRNA ligase activity
ISA75_RS21225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ISA75_RS21265	COG3137	Salt-induced outer membrane protein
ISA75_RS21270	COG1105	Belongs to the carbohydrate kinase PfkB family
ISA75_RS21280	COG3001	Fructosamine kinase
ISA75_RS21290	COG2350	Protein conserved in bacteria
ISA75_RS21295	COG4993	Dehydrogenase
ISA75_RS21300	COG2353	YceI-like domain
ISA75_RS21320	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISA75_RS21330	COG0444	Belongs to the ABC transporter superfamily
ISA75_RS21335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISA75_RS21340	COG0601	transmembrane transport
ISA75_RS21345	COG4166	transmembrane transport
ISA75_RS21350	COG2095	MarC family integral membrane protein
ISA75_RS21360	COG1454	alcohol dehydrogenase
ISA75_RS21360	COG1012	belongs to the aldehyde dehydrogenase family
ISA75_RS21365	COG1435	thymidine kinase activity
ISA75_RS21370	COG2916	Histone family protein nucleoid-structuring protein H-NS
ISA75_RS21375	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISA75_RS21380	COG0745	RESPONSE REGULATOR receiver
ISA75_RS21385	COG1752	Esterase of the alpha-beta hydrolase superfamily
ISA75_RS21395	COG0788	formyltetrahydrofolate deformylase activity
ISA75_RS21425	COG1522	sequence-specific DNA binding
ISA75_RS21435	COG2181	nitrate reductase activity
ISA75_RS21440	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
ISA75_RS21445	COG1140	nitrate reductase beta subunit
ISA75_RS21450	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ISA75_RS21455	COG2223	nitrite transmembrane transporter activity
ISA75_RS21460	COG3850	Histidine kinase
ISA75_RS21465	COG2197	response regulator
ISA75_RS21470	COG4932	domain protein
ISA75_RS21475	COG0243	molybdopterin cofactor binding
ISA75_RS21480	COG2146	nitrite reductase [NAD(P)H] activity
ISA75_RS21480	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISA75_RS21485	COG1116	anion transmembrane transporter activity
ISA75_RS21495	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISA75_RS21500	COG3707	response regulator
ISA75_RS21505	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ISA75_RS21515	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
ISA75_RS21520	COG4572	Cation transport regulator
ISA75_RS21525	COG0387	Pfam Sodium calcium exchanger
ISA75_RS21545	COG2890	protein-(glutamine-N5) methyltransferase activity
ISA75_RS21575	COG0659	secondary active sulfate transmembrane transporter activity
ISA75_RS21595	COG0012	GTP binding
ISA75_RS21665	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ISA75_RS21685	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ISA75_RS21710	COG2885	chlorophyll binding
ISA75_RS21730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ISA75_RS21745	COG0800	Aldolase
ISA75_RS21750	COG3734	2-keto-3-deoxy-galactonokinase
ISA75_RS21755	COG2186	Transcriptional regulator
ISA75_RS21760	COG3122	Protein conserved in bacteria
ISA75_RS21775	COG0583	DNA-binding transcription factor activity
ISA75_RS21805	COG0583	DNA-binding transcription factor activity
ISA75_RS21840	COG1882	Formate acetyltransferase
ISA75_RS21855	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ISA75_RS21860	COG0583	DNA-binding transcription factor activity
ISA75_RS21880	COG1174	glycine betaine transport
ISA75_RS21890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISA75_RS21905	COG1940	carbohydrate kinase activity
ISA75_RS21920	COG0395	ABC-type sugar transport system, permease component
ISA75_RS21925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISA75_RS21930	COG3842	ATPase activity
ISA75_RS21950	COG2308	Evidence 4 Homologs of previously reported genes of
ISA75_RS21965	COG4774	siderophore transport
ISA75_RS21985	COG1619	proteins homologs of microcin C7 resistance protein MccF
ISA75_RS22010	COG2719	SpoVR family
ISA75_RS22040	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISA75_RS22055	COG2894	cell division
ISA75_RS22065	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ISA75_RS22075	COG3065	identical protein binding
ISA75_RS22085	COG1199	ATP-dependent helicase activity
ISA75_RS22090	COG0251	oxidation-reduction process
ISA75_RS22110	COG1760	l-serine dehydratase
ISA75_RS22115	COG2200	EAL domain
ISA75_RS22120	COG1253	flavin adenine dinucleotide binding
ISA75_RS22125	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA75_RS22125	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA75_RS22130	COG3715	PTS system
ISA75_RS22135	COG3716	PTS system mannose fructose sorbose family IID component
ISA75_RS22150	COG2226	methyltransferase
ISA75_RS22155	COG0768	penicillin binding
ISA75_RS22190	COG1414	Transcriptional regulator
ISA75_RS22195	COG2814	Major facilitator Superfamily
ISA75_RS22215	COG1956	GAF domain-containing protein
ISA75_RS22220	COG2995	paraquat-inducible protein a
ISA75_RS22225	COG3008	intermembrane lipid transfer
ISA75_RS22250	COG2990	Protein conserved in bacteria
ISA75_RS22265	COG1276	copper resistance
ISA75_RS22270	COG2372	response to copper ion
ISA75_RS22280	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISA75_RS22285	COG1770	oligopeptidase
ISA75_RS22290	COG2979	Protein of unknown function (DUF533)
ISA75_RS22295	COG3141	response to X-ray
ISA75_RS22305	COG0800	Aldolase
ISA75_RS22310	COG0129	dihydroxy-acid dehydratase activity
ISA75_RS22315	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISA75_RS22325	COG1737	Transcriptional regulator
ISA75_RS22335	COG3493	citrate carrier protein
ISA75_RS22355	COG1560	Kdo2-lipid A biosynthetic process
ISA75_RS22360	COG0739	heme binding
ISA75_RS22365	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ISA75_RS22375	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISA75_RS22400	COG0494	nUDIX hydrolase
ISA75_RS22410	COG1335	isochorismatase
ISA75_RS22415	COG1801	Protein of unknown function DUF72
ISA75_RS22475	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ISA75_RS22485	COG3788	relative of glutathione S-transferase, MAPEG superfamily
ISA75_RS22505	COG3102	Protein conserved in bacteria
ISA75_RS22515	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ISA75_RS22540	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA75_RS22550	COG1879	ABC-type sugar transport system periplasmic component
ISA75_RS22555	COG1528	Iron-storage protein
ISA75_RS22560	COG2211	Major facilitator Superfamily
ISA75_RS22570	COG0477	Major facilitator Superfamily
ISA75_RS22585	COG1528	Iron-storage protein
ISA75_RS22595	COG0814	amino acid
ISA75_RS22600	COG3318	Belongs to the UPF0149 family
ISA75_RS22600	COG3012	SEC-C Motif Domain Protein
ISA75_RS22640	COG2197	response regulator
ISA75_RS22650	COG2197	response regulator
ISA75_RS22655	COG1126	abc transporter atp-binding protein
ISA75_RS22660	COG0765	amino acid transport
ISA75_RS22670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA75_RS22675	COG0366	Alpha amylase catalytic
ISA75_RS22705	COG2354	Protein conserved in bacteria
ISA75_RS22710	COG0697	spore germination
ISA75_RS22715	COG3727	T/G mismatch-specific endonuclease activity
ISA75_RS22720	COG0270	DNA (cytosine-5-)-methyltransferase activity
ISA75_RS22725	COG1418	mRNA catabolic process
ISA75_RS22735	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ISA75_RS22760	COG0523	cobalamin synthesis protein
ISA75_RS22770	COG1028	Short-chain dehydrogenase reductase Sdr
ISA75_RS22820	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ISA75_RS22825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISA75_RS22845	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ISA75_RS22850	COG1045	serine acetyltransferase
ISA75_RS22855	COG0025	NhaP-type Na H and K H
ISA75_RS22860	COG1309	transcriptional regulator
ISA75_RS22865	COG0604	alcohol dehydrogenase
ISA75_RS22885	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ISA75_RS22895	COG0534	Mate efflux family protein
ISA75_RS22920	COG3706	GGDEF domain
ISA75_RS22945	COG3615	Tellurite resistance protein tehB
ISA75_RS22955	COG3300	MHYT domain
ISA75_RS22955	COG5001	Diguanylate cyclase
ISA75_RS22965	COG0477	Major facilitator Superfamily
ISA75_RS22970	COG0095	Lipoate-protein ligase
ISA75_RS22975	COG0583	DNA-binding transcription factor activity
ISA75_RS22980	COG1942	4-Oxalocrotonate Tautomerase
ISA75_RS22990	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ISA75_RS23010	COG1289	transmembrane transporter activity
ISA75_RS23025	COG2925	Exonuclease
ISA75_RS23030	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ISA75_RS23035	COG0640	Transcriptional regulator
ISA75_RS23120	COG2205	protein histidine kinase activity
ISA75_RS23125	COG3604	Transcriptional regulator
ISA75_RS23140	COG0531	amino acid
ISA75_RS23150	COG0583	DNA-binding transcription factor activity
ISA75_RS23155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISA75_RS23185	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ISA75_RS23205	COG1215	transferase activity, transferring glycosyl groups
ISA75_RS23210	COG0438	transferase activity, transferring glycosyl groups
ISA75_RS23275	COG0438	transferase activity, transferring glycosyl groups
ISA75_RS23350	COG1253	flavin adenine dinucleotide binding
ISA75_RS23355	COG2982	Protein involved in outer membrane biogenesis
ISA75_RS23370	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ISA75_RS23375	COG0443	Heat shock 70 kDa protein
ISA75_RS23380	COG5002	protein histidine kinase activity
ISA75_RS23400	COG1301	dicarboxylic acid transport
ISA75_RS23425	COG2205	protein histidine kinase activity
ISA75_RS23430	COG0745	RESPONSE REGULATOR receiver
ISA75_RS23435	COG0826	peptidase U32
ISA75_RS23445	COG4608	Belongs to the ABC transporter superfamily
ISA75_RS23450	COG0444	Belongs to the ABC transporter superfamily
ISA75_RS23455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISA75_RS23460	COG0601	transmembrane transport
ISA75_RS23465	COG0747	negative chemotaxis
ISA75_RS23470	COG4948	Mandelate Racemase Muconate Lactonizing
ISA75_RS23475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISA75_RS23485	COG1070	Carbohydrate kinase
ISA75_RS23500	COG1830	Aldolase
ISA75_RS23505	COG0351	phosphomethylpyrimidine kinase
ISA75_RS23520	COG0583	DNA-binding transcription factor activity
ISA75_RS23530	COG2252	PERMEase
ISA75_RS23535	COG0583	DNA-binding transcription factor activity
ISA75_RS23540	COG5455	response to cobalt ion
ISA75_RS23560	COG4807	Protein conserved in bacteria
ISA75_RS23570	COG3275	phosphorelay sensor kinase activity
ISA75_RS23580	COG1174	glycine betaine transport
ISA75_RS23585	COG1125	glycine betaine transport
ISA75_RS23590	COG1174	glycine betaine transport
ISA75_RS23595	COG1732	Glycine betaine
ISA75_RS23600	COG1472	Belongs to the glycosyl hydrolase 3 family
ISA75_RS23605	COG0277	FAD linked oxidase domain protein
ISA75_RS23615	COG1686	Belongs to the peptidase S11 family
ISA75_RS23625	COG0586	Pfam SNARE associated Golgi protein
ISA75_RS23630	COG1538	Outer membrane efflux protein
ISA75_RS23640	COG2723	6-phospho-beta-galactosidase activity
ISA75_RS23655	COG3659	wide pore channel activity
ISA75_RS23660	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISA75_RS23670	COG1346	cytolysis
ISA75_RS23685	COG2949	membrane
ISA75_RS23705	COG1129	ABC transporter
ISA75_RS23720	COG2311	Membrane
ISA75_RS23735	COG4771	TonB-dependent receptor
ISA75_RS23740	COG0833	amino acid
ISA75_RS23745	COG0583	DNA-binding transcription factor activity
ISA75_RS23750	COG2855	membrane
ISA75_RS23760	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISA75_RS23760	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISA75_RS23760	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ISA75_RS23765	COG1105	Belongs to the carbohydrate kinase PfkB family
ISA75_RS23770	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA75_RS23770	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA75_RS23775	COG2814	Major facilitator Superfamily
ISA75_RS23780	COG1566	PFAM secretion protein HlyD family protein
ISA75_RS23805	COG1312	Catalyzes the dehydration of D-mannonate
ISA75_RS23810	COG0246	Mannitol dehydrogenase
ISA75_RS23815	COG0523	cobalamin synthesis protein
ISA75_RS23820	COG0671	phosphoesterase, PA-phosphatase related
ISA75_RS23825	COG0791	NLP P60 protein
ISA75_RS23830	COG2200	EAL domain
ISA75_RS23835	COG4166	transmembrane transport
ISA75_RS23840	COG4174	ABC transporter (Permease)
ISA75_RS23845	COG4239	(ABC) transporter, permease
ISA75_RS23850	COG4172	Belongs to the ABC transporter superfamily
ISA75_RS23860	COG2814	Major facilitator Superfamily
ISA75_RS23865	COG1187	pseudouridine synthase activity
ISA75_RS23870	COG1061	Type III restriction enzyme res subunit
ISA75_RS23890	COG0494	nUDIX hydrolase
ISA75_RS23895	COG1349	DNA-binding transcription factor activity
ISA75_RS23920	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ISA75_RS23935	COG0765	amino acid transport
ISA75_RS23940	COG0765	amino acid transport
ISA75_RS23945	COG1126	abc transporter atp-binding protein
ISA75_RS23960	COG0628	permease
ISA75_RS23975	COG0659	secondary active sulfate transmembrane transporter activity
ISA75_RS23980	COG2239	Acts as a magnesium transporter
ISA75_RS23985	COG4615	Cyclic peptide transporter
ISA75_RS23990	COG3145	DNA-N1-methyladenine dioxygenase activity
ISA75_RS23995	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ISA75_RS23995	COG2169	Transcriptional regulator
ISA75_RS24010	COG0642	Histidine kinase
ISA75_RS24010	COG2198	Histidine kinase
ISA75_RS24045	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISA75_RS24050	COG0584	glycerophosphoryl diester phosphodiesterase
ISA75_RS24055	COG2271	Major facilitator Superfamily
ISA75_RS24060	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ISA75_RS24070	COG0247	lactate metabolic process
ISA75_RS24080	COG2271	Major facilitator Superfamily
ISA75_RS24090	COG1414	Transcriptional regulator
ISA75_RS24105	COG5464	transposase or invertase
ISA75_RS24115	COG0318	PFAM AMP-dependent synthetase and ligase
ISA75_RS24140	COG1169	isochorismate synthase
ISA75_RS24145	COG2153	protein acetylation
ISA75_RS24160	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISA75_RS24165	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ISA75_RS24175	COG0839	Belongs to the complex I subunit 6 family
ISA75_RS24220	COG0583	DNA-binding transcription factor activity
ISA75_RS24225	COG0436	Aminotransferase
ISA75_RS24235	COG0471	metal ion transport
ISA75_RS24235	COG0490	domain, Protein
ISA75_RS24240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISA75_RS24265	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ISA75_RS24270	COG0622	Phosphoesterase
ISA75_RS24275	COG0625	glutathione transferase activity
ISA75_RS24280	COG0625	glutathione transferase activity
ISA75_RS24285	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ISA75_RS24290	COG1090	epimerase
ISA75_RS24305	COG4598	ABC transporter
ISA75_RS24310	COG4160	amino acid transport
ISA75_RS24335	COG0163	prenyltransferase activity
ISA75_RS24340	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ISA75_RS24345	COG1286	toxin biosynthetic process
ISA75_RS24350	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ISA75_RS24355	COG0285	dihydrofolate synthase activity
ISA75_RS24365	COG0586	Pfam SNARE associated Golgi protein
ISA75_RS24375	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ISA75_RS24395	COG1447	Phosphotransferase system cellobiose-specific component IIA
ISA75_RS24400	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA75_RS24410	COG2188	Transcriptional regulator
ISA75_RS24420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISA75_RS24435	COG3101	peptidyl-lysine hydroxylation
ISA75_RS24440	COG0730	response to heat
ISA75_RS24465	COG2062	phosphohistidine phosphatase, SixA
ISA75_RS24480	COG3691	Protein conserved in bacteria
ISA75_RS24490	COG2853	Lipoprotein
ISA75_RS24495	COG2116	formate transmembrane transporter activity
ISA75_RS24655	COG2885	chlorophyll binding
ISA75_RS24690	COG0583	DNA-binding transcription factor activity
ISA75_RS24695	COG0590	tRNA wobble adenosine to inosine editing
ISA75_RS24700	COG2807	transmembrane transport
ISA75_RS24710	COG0436	Aminotransferase
ISA75_RS24725	COG3275	phosphorelay sensor kinase activity
ISA75_RS24730	COG3279	Response regulator of the LytR AlgR family
ISA75_RS24745	COG3961	Belongs to the TPP enzyme family
ISA75_RS24750	COG0667	Aldo Keto reductase
ISA75_RS24765	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISA75_RS24770	COG2200	EAL domain
ISA75_RS24770	COG2199	diguanylate cyclase activity
ISA75_RS24785	COG3415	Transposase
ISA75_RS24790	COG3415	Transposase
ISA75_RS24820	COG0583	DNA-binding transcription factor activity
ISA75_RS24825	COG0385	Bile acid
ISA75_RS24830	COG3530	Putative quorum-sensing-regulated virulence factor
ISA75_RS24850	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ISA75_RS24885	COG4319	ketosteroid isomerase
ISA75_RS24895	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ISA75_RS24900	COG4208	sulfate ABC transporter
ISA75_RS24905	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ISA75_RS24910	COG4150	thiosulfate binding
ISA75_RS24920	COG2837	iron assimilation
ISA75_RS24940	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISA75_RS25000	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
ISA75_RS25030	COG4810	utilization protein
ISA75_RS25040	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISA75_RS25045	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ISA75_RS25050	COG5342	invasion associated locus B
ISA75_RS25060	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISA75_RS25060	COG0493	'glutamate synthase
ISA75_RS25065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISA75_RS25075	COG1393	Belongs to the ArsC family
ISA75_RS25090	COG0400	carboxylic ester hydrolase activity
ISA75_RS25095	COG1444	tRNA N-acetyltransferase activity
ISA75_RS25100	COG2321	neutral zinc metallopeptidase
ISA75_RS25110	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ISA75_RS25120	COG2716	regulation of RNA biosynthetic process
ISA75_RS25125	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ISA75_RS25130	COG0628	permease
ISA75_RS25140	COG4783	chaperone-mediated protein folding
ISA75_RS25145	COG1393	Belongs to the ArsC family
ISA75_RS25160	COG2233	PERMEase
ISA75_RS25170	COG2723	6-phospho-beta-galactosidase activity
ISA75_RS25185	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ISA75_RS25200	COG2200	EAL domain
ISA75_RS25225	COG0516	GMP reductase activity
ISA75_RS25225	COG0517	IMP dehydrogenase activity
ISA75_RS25235	COG1645	bacterial-type flagellum-dependent swarming motility
ISA75_RS25255	COG2976	Protein conserved in bacteria
ISA75_RS25285	COG4953	penicillin-binding protein 1C
ISA75_RS25290	COG2373	Large extracellular alpha-helical protein
ISA75_RS25295	COG2897	thiosulfate sulfurtransferase activity
ISA75_RS25315	COG2975	iron-sulfur cluster assembly
ISA75_RS25320	COG0633	Ferredoxin
ISA75_RS25340	COG0822	iron-sulfur transferase activity
ISA75_RS25370	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ISA75_RS25375	COG3683	transport system, periplasmic component
ISA75_RS25380	COG3711	transcriptional antiterminator
ISA75_RS25385	COG2814	Major facilitator Superfamily
ISA75_RS25390	COG2259	Doxx family
ISA75_RS25400	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISA75_RS25400	COG1017	nitric oxide dioxygenase activity
ISA75_RS25405	COG0347	Belongs to the P(II) protein family
ISA75_RS25410	COG2204	response regulator
ISA75_RS25415	COG3170	Tfp pilus assembly protein FimV
ISA75_RS25420	COG2205	protein histidine kinase activity
ISA75_RS25425	COG0047	phosphoribosylformylglycinamidine synthase activity
ISA75_RS25425	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ISA75_RS25440	COG0560	Phosphoserine phosphatase
ISA75_RS25445	COG1737	Transcriptional regulator
ISA75_RS25450	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISA75_RS25460	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ISA75_RS25480	COG0681	Belongs to the peptidase S26 family
ISA75_RS25490	COG3086	response to oxidative stress
ISA75_RS25495	COG3026	antisigma factor binding
ISA75_RS25500	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
ISA75_RS25515	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ISA75_RS25525	COG0513	Belongs to the DEAD box helicase family
ISA75_RS25540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISA75_RS25545	COG3118	belongs to the thioredoxin family
ISA75_RS25550	COG3148	PFAM DTW domain containing protein
ISA75_RS25560	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISA75_RS25565	COG5544	Lipoprotein
ISA75_RS25570	COG0477	Major facilitator Superfamily
ISA75_RS25595	COG0542	response to heat
ISA75_RS25610	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISA75_RS25615	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ISA75_RS25625	COG1605	Chorismate mutase
ISA75_RS25625	COG0077	Prephenate dehydratase
ISA75_RS25635	COG0287	Prephenate dehydrogenase
ISA75_RS25635	COG1605	Chorismate mutase
ISA75_RS25640	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISA75_RS25650	COG2199	diguanylate cyclase activity
ISA75_RS25655	COG2885	chlorophyll binding
ISA75_RS25690	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ISA75_RS25695	COG4137	Cytochrome C assembly protein
ISA75_RS25700	COG4536	flavin adenine dinucleotide binding
ISA75_RS25715	COG0497	DNA recombination
ISA75_RS25730	COG2867	negative regulation of translational initiation
ISA75_RS25895	COG4695	Portal protein
ISA75_RS25940	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ISA75_RS25975	COG4974	Belongs to the 'phage' integrase family
ISA75_RS26000	COG2207	Transcriptional regulator
ISA75_RS26000	COG3708	Transcriptional regulator
ISA75_RS26005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA75_RS26045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA75_RS26050	COG1126	abc transporter atp-binding protein
ISA75_RS26055	COG0235	Class ii aldolase
ISA75_RS26065	COG1028	Short-chain dehydrogenase reductase Sdr
ISA75_RS26100	COG3121	Chaperone
ISA75_RS26105	COG3539	Fimbrial protein
ISA75_RS26115	COG3284	Transcriptional regulator
ISA75_RS26120	COG0671	phosphoesterase, PA-phosphatase related
ISA75_RS26125	COG0583	DNA-binding transcription factor activity
ISA75_RS26135	COG0640	Transcriptional regulator
ISA75_RS26140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ISA75_RS26170	COG4575	ribosome binding
ISA75_RS26180	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISA75_RS26185	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ISA75_RS26195	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISA75_RS26210	COG4176	ABC-type proline glycine betaine transport system permease component
ISA75_RS26220	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ISA75_RS26230	COG1846	Transcriptional regulator
ISA75_RS26235	COG1566	PFAM secretion protein HlyD family protein
ISA75_RS26240	COG2814	Major facilitator Superfamily
ISA75_RS26245	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ISA75_RS26265	COG1238	metal cluster binding
ISA75_RS26270	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISA75_RS26275	COG2823	Periplasmic or secreted lipoprotein
ISA75_RS26305	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ISA75_RS26325	COG1546	Belongs to the CinA family
ISA75_RS26330	COG0803	Belongs to the bacterial solute-binding protein 9 family
ISA75_RS26335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISA75_RS26340	COG1121	(ABC) transporter
ISA75_RS26345	COG2951	lytic endotransglycosylase activity
ISA75_RS26350	COG3730	PTS system glucitol sorbitol-specific
ISA75_RS26355	COG3732	PTS system glucitol sorbitol-specific
ISA75_RS26365	COG1028	Short-chain dehydrogenase reductase Sdr
ISA75_RS26370	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA75_RS26375	COG1349	DNA-binding transcription factor activity
ISA75_RS26400	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ISA75_RS26405	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ISA75_RS26410	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISA75_RS26415	COG1609	Transcriptional regulator
ISA75_RS26420	COG1263	PTS System
ISA75_RS26420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA75_RS26425	COG2723	6-phospho-beta-galactosidase activity
ISA75_RS26435	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ISA75_RS26445	COG3260	NADH ubiquinone oxidoreductase 20
ISA75_RS26450	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISA75_RS26455	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
ISA75_RS26455	COG3261	NADH dehydrogenase
ISA75_RS26460	COG0650	Formate hydrogenlyase subunit 4
ISA75_RS26465	COG0651	ATP synthesis coupled electron transport
ISA75_RS26470	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISA75_RS26485	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ISA75_RS26490	COG0298	carbon dioxide binding
ISA75_RS26495	COG0409	Hydrogenase expression formation protein
ISA75_RS26500	COG0309	Hydrogenase expression formation protein (HypE)
ISA75_RS26510	COG2723	6-phospho-beta-galactosidase activity
ISA75_RS26520	COG4580	involved in the transport of maltose and maltodextrins
ISA75_RS26525	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA75_RS26530	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA75_RS26535	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA75_RS26540	COG1447	Phosphotransferase system cellobiose-specific component IIA
ISA75_RS26550	COG1609	Transcriptional regulator
ISA75_RS26555	COG0803	Belongs to the bacterial solute-binding protein 9 family
ISA75_RS26560	COG1121	(ABC) transporter
ISA75_RS26565	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISA75_RS26570	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISA75_RS26585	COG0679	Auxin Efflux Carrier
ISA75_RS26615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA75_RS26655	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ISA75_RS26660	COG0163	prenyltransferase activity
ISA75_RS26685	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISA75_RS26770	COG0584	glycerophosphoryl diester phosphodiesterase
ISA75_RS26785	COG1247	-acetyltransferase
ISA75_RS26800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISA75_RS26800	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ISA75_RS26810	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ISA75_RS26880	COG1132	(ABC) transporter
ISA75_RS26910	COG1733	regulation of RNA biosynthetic process
ISA75_RS26915	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ISA75_RS26920	COG2249	NAD(P)H dehydrogenase (quinone) activity
ISA75_RS26925	COG0667	Aldo Keto reductase
ISA75_RS26985	COG3706	GGDEF domain
ISA75_RS26995	COG2203	Gaf domain
ISA75_RS26995	COG4251	negative regulation of phosphorylation
ISA75_RS26995	COG3706	GGDEF domain
ISA75_RS26995	COG5001	Diguanylate cyclase
ISA75_RS27010	COG1609	Transcriptional regulator
ISA75_RS27015	COG0366	Alpha amylase catalytic
ISA75_RS27055	COG2207	Transcriptional regulator
ISA75_RS27060	COG2807	transmembrane transport
ISA75_RS27065	COG2249	NAD(P)H dehydrogenase (quinone) activity
ISA75_RS27095	COG3477	response to acidic pH
ISA75_RS27105	COG4608	Belongs to the ABC transporter superfamily
ISA75_RS27110	COG0444	Belongs to the ABC transporter superfamily
ISA75_RS27115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISA75_RS27120	COG0601	transmembrane transport
ISA75_RS27125	COG2267	carboxylic ester hydrolase activity
ISA75_RS27135	COG2267	carboxylic ester hydrolase activity
ISA75_RS27150	COG0156	8-amino-7-oxononanoate synthase activity
ISA75_RS27160	COG0366	Alpha amylase catalytic
ISA75_RS27165	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ISA75_RS27170	COG1127	ABC transporter
ISA75_RS27205	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
ISA75_RS27210	COG4221	oxidoreductase activity
ISA75_RS27220	COG4221	oxidoreductase activity
ISA75_RS27220	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISA75_RS27220	COG0604	alcohol dehydrogenase
ISA75_RS27220	COG3321	synthase
ISA75_RS27235	COG0583	DNA-binding transcription factor activity
ISA75_RS27245	COG1028	Short-chain dehydrogenase reductase Sdr
ISA75_RS27250	COG2207	Transcriptional regulator
ISA75_RS27255	COG1733	regulation of RNA biosynthetic process
ISA75_RS27260	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ISA75_RS27270	COG0583	DNA-binding transcription factor activity
ISA75_RS27295	COG0583	DNA-binding transcription factor activity
ISA75_RS27300	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ISA75_RS27310	COG1811	Na channel or pump
ISA75_RS27315	COG0406	alpha-ribazole phosphatase activity
ISA75_RS27325	COG5001	Diguanylate cyclase
ISA75_RS27325	COG4251	negative regulation of phosphorylation
ISA75_RS27325	COG2203	Gaf domain
ISA75_RS27325	COG3706	GGDEF domain
ISA75_RS27345	COG0583	DNA-binding transcription factor activity
ISA75_RS27375	COG2271	Major facilitator Superfamily
ISA75_RS27380	COG3732	PTS system glucitol sorbitol-specific
ISA75_RS27435	COG1196	nuclear chromosome segregation
ISA75_RS27460	COG2826	transposase and inactivated derivatives, IS30 family
ISA75_RS27500	COG0346	lactoylglutathione lyase activity
ISA75_RS27505	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
ISA75_RS27590	COG3547	Transposase (IS116 IS110 IS902 family)
ISA75_RS27595	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ISA75_RS27615	COG1472	Belongs to the glycosyl hydrolase 3 family
ISA75_RS27625	COG1609	Transcriptional regulator
ISA75_RS27640	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA75_RS27645	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA75_RS27650	COG2723	6-phospho-beta-galactosidase activity
ISA75_RS27655	COG1447	Phosphotransferase system cellobiose-specific component IIA
ISA75_RS27695	COG2944	sequence-specific DNA binding
ISA75_RS27775	COG1121	(ABC) transporter
ISA75_RS27905	COG1064	alcohol dehydrogenase
ISA75_RS27945	COG1473	amidohydrolase
ISA75_RS27960	COG1733	regulation of RNA biosynthetic process
ISA75_RS27965	COG1064	alcohol dehydrogenase
ISA75_RS27975	COG2200	EAL domain
ISA75_RS28020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ISA75_RS28060	COG0456	acetyltransferase
ISA75_RS28060	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ISA75_RS28065	COG2801	Transposase and inactivated derivatives