locus-tag	class	description
HL854_RS00025	COG0561	phosphatase activity
HL854_RS00040	COG0823	Involved in the tonB-independent uptake of proteins
HL854_RS00045	COG5645	(Lipo)protein
HL854_RS00065	COG2188	Transcriptional regulator
HL854_RS00080	COG2149	membrane
HL854_RS00090	COG0641	radical SAM
HL854_RS00100	COG2610	gluconate transmembrane transporter activity
HL854_RS00110	COG0583	DNA-binding transcription factor activity
HL854_RS00115	COG2814	Major facilitator Superfamily
HL854_RS00145	COG0028	Belongs to the TPP enzyme family
HL854_RS00150	COG0440	acetolactate synthase activity
HL854_RS00155	COG2197	response regulator
HL854_RS00165	COG2271	Major facilitator Superfamily
HL854_RS00175	COG0583	DNA-binding transcription factor activity
HL854_RS00195	COG4580	involved in the transport of maltose and maltodextrins
HL854_RS00200	COG1447	Phosphotransferase system cellobiose-specific component IIA
HL854_RS00205	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HL854_RS00205	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HL854_RS00215	COG1609	Transcriptional regulator
HL854_RS00225	COG3384	dioxygenase
HL854_RS00230	COG0583	DNA-binding transcription factor activity
HL854_RS00235	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HL854_RS00240	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HL854_RS00245	COG2828	Protein conserved in bacteria
HL854_RS00260	COG0697	spore germination
HL854_RS00265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HL854_RS00265	COG1263	PTS System
HL854_RS00275	COG2814	Major facilitator Superfamily
HL854_RS00285	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HL854_RS00310	COG1309	transcriptional regulator
HL854_RS00320	COG0583	DNA-binding transcription factor activity
HL854_RS00345	COG1464	Belongs to the NlpA lipoprotein family
HL854_RS00360	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HL854_RS00370	COG1064	alcohol dehydrogenase
HL854_RS00400	COG2211	Major facilitator Superfamily
HL854_RS00405	COG1501	Belongs to the glycosyl hydrolase 31 family
HL854_RS00415	COG1486	melibiose metabolic process
HL854_RS00420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HL854_RS00420	COG1263	PTS System
HL854_RS00425	COG2982	Protein involved in outer membrane biogenesis
HL854_RS00430	COG2233	PERMEase
HL854_RS00435	COG0786	glutamate:sodium symporter activity
HL854_RS00450	COG3074	FtsZ-dependent cytokinesis
HL854_RS00455	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HL854_RS00480	COG3152	Membrane
HL854_RS00490	COG1494	fructose-1,6-bisphosphatase
HL854_RS00495	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HL854_RS00500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HL854_RS00505	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HL854_RS00525	COG2860	membrane
HL854_RS00535	COG2169	Transcriptional regulator
HL854_RS00535	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HL854_RS00545	COG1561	YicC-like family, N-terminal region
HL854_RS00560	COG1131	(ABC) transporter
HL854_RS00565	COG0842	Transport permease protein
HL854_RS00595	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HL854_RS00605	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HL854_RS00615	COG4245	von Willebrand factor, type A
HL854_RS00650	COG1519	Transferase
HL854_RS00655	COG1216	Glycosyl transferase, family 2
HL854_RS00660	COG0438	transferase activity, transferring glycosyl groups
HL854_RS00670	COG0859	PFAM glycosyl transferase family 9
HL854_RS00695	COG0859	PFAM glycosyl transferase family 9
HL854_RS00710	COG0156	8-amino-7-oxononanoate synthase activity
HL854_RS00720	COG0463	Glycosyl transferase, family 2
HL854_RS00725	COG2861	carbohydrate metabolic process
HL854_RS00730	COG4942	peptidase
HL854_RS00740	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HL854_RS00745	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HL854_RS00765	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HL854_RS00775	COG2186	Transcriptional regulator
HL854_RS00795	COG3722	fumarate hydratase activity
HL854_RS00815	COG1566	PFAM secretion protein HlyD family protein
HL854_RS00820	COG0625	glutathione transferase activity
HL854_RS00830	COG3276	selenocysteine insertion sequence binding
HL854_RS00835	COG0235	Class ii aldolase
HL854_RS00840	COG3623	hexulose-6-phosphate isomerase
HL854_RS00845	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HL854_RS00850	COG1070	Carbohydrate kinase
HL854_RS00855	COG2271	Major facilitator Superfamily
HL854_RS00865	COG2731	YhcH YjgK YiaL family protein
HL854_RS00875	COG1414	Transcriptional regulator
HL854_RS00880	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HL854_RS00885	COG3977	Valine--pyruvate aminotransferase
HL854_RS00890	COG0366	Alpha amylase catalytic
HL854_RS00895	COG2992	FlgJ-related protein
HL854_RS00900	COG2207	Transcriptional regulator
HL854_RS00900	COG1609	Transcriptional regulator
HL854_RS00905	COG4214	carbohydrate transport
HL854_RS00915	COG4213	ABC transporter substrate-binding protein
HL854_RS00930	COG4682	membrane
HL854_RS00935	COG4682	membrane
HL854_RS00940	COG3274	enterobacterial common antigen metabolic process
HL854_RS00965	COG0488	(ABC) transporter
HL854_RS00970	COG1278	Cold shock
HL854_RS00975	COG2944	sequence-specific DNA binding
HL854_RS00980	COG2814	Major facilitator Superfamily
HL854_RS01000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HL854_RS01010	COG1609	Transcriptional regulator
HL854_RS01015	COG2885	chlorophyll binding
HL854_RS01020	COG0243	molybdopterin cofactor binding
HL854_RS01025	COG0456	acetyltransferase
HL854_RS01030	COG2818	Glycosylase
HL854_RS01035	COG5571	outer membrane autotransporter
HL854_RS01040	COG2223	nitrite transmembrane transporter activity
HL854_RS01065	COG0747	negative chemotaxis
HL854_RS01070	COG0601	transmembrane transport
HL854_RS01075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HL854_RS01080	COG0444	Belongs to the ABC transporter superfamily
HL854_RS01085	COG4608	Belongs to the ABC transporter superfamily
HL854_RS01100	COG2894	cell division
HL854_RS01110	COG1215	transferase activity, transferring glycosyl groups
HL854_RS01115	COG0457	Tetratricopeptide repeat
HL854_RS01130	COG2194	sulfuric ester hydrolase activity
HL854_RS01160	COG1215	transferase activity, transferring glycosyl groups
HL854_RS01165	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HL854_RS01170	COG3118	belongs to the thioredoxin family
HL854_RS01170	COG0457	Tetratricopeptide repeat
HL854_RS01175	COG2200	EAL domain
HL854_RS01175	COG2199	diguanylate cyclase activity
HL854_RS01185	COG0612	Peptidase, M16
HL854_RS01195	COG2982	Protein involved in outer membrane biogenesis
HL854_RS01200	COG0477	Major facilitator Superfamily
HL854_RS01205	COG1295	ribonuclease BN
HL854_RS01210	COG0583	DNA-binding transcription factor activity
HL854_RS01215	COG1028	Short-chain dehydrogenase reductase Sdr
HL854_RS01220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HL854_RS01230	COG1454	alcohol dehydrogenase
HL854_RS01240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HL854_RS01245	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HL854_RS01250	COG0671	phosphoesterase, PA-phosphatase related
HL854_RS01270	COG0589	response to stress
HL854_RS01280	COG0306	phosphate transporter
HL854_RS01285	COG2081	HI0933 family
HL854_RS01290	COG2239	Acts as a magnesium transporter
HL854_RS01300	COG1124	(ABC) transporter
HL854_RS01310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HL854_RS01315	COG0601	transmembrane transport
HL854_RS01320	COG0747	negative chemotaxis
HL854_RS01330	COG3479	Phenolic acid decarboxylase
HL854_RS01370	COG0628	permease
HL854_RS01375	COG0477	Major facilitator Superfamily
HL854_RS01385	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HL854_RS01400	COG3714	YhhN family
HL854_RS01410	COG3776	membrane
HL854_RS01415	COG0742	ribosomal rna small subunit methyltransferase
HL854_RS01420	COG0552	protein localization to endoplasmic reticulum
HL854_RS01425	COG2884	Cell division ATP-binding protein ftsE
HL854_RS01430	COG2177	Part of the ABC transporter FtsEX involved in
HL854_RS01445	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HL854_RS01455	COG0683	leucine binding
HL854_RS01465	COG0683	leucine binding
HL854_RS01470	COG0559	Belongs to the binding-protein-dependent transport system permease family
HL854_RS01520	COG0584	glycerophosphoryl diester phosphodiesterase
HL854_RS01530	COG0405	Gamma-glutamyltransferase
HL854_RS01535	COG1247	-acetyltransferase
HL854_RS01545	COG0673	inositol 2-dehydrogenase activity
HL854_RS01550	COG1741	Belongs to the pirin family
HL854_RS01555	COG1609	Transcriptional regulator
HL854_RS01560	COG3265	gluconokinase activity
HL854_RS01565	COG2610	gluconate transmembrane transporter activity
HL854_RS01575	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HL854_RS01600	COG0058	SHG alpha-glucan phosphorylase activity
HL854_RS01615	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HL854_RS01630	COG1349	DNA-binding transcription factor activity
HL854_RS01640	COG0058	SHG alpha-glucan phosphorylase activity
HL854_RS01645	COG1640	4-alpha-glucanotransferase
HL854_RS01650	COG2610	gluconate transmembrane transporter activity
HL854_RS01660	COG1040	competence protein
HL854_RS01685	COG1918	ferrous iron import across plasma membrane
HL854_RS01690	COG2183	response to ionizing radiation
HL854_RS01695	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HL854_RS01700	COG0745	RESPONSE REGULATOR receiver
HL854_RS01720	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HL854_RS01725	COG1011	Hydrolase
HL854_RS01735	COG0494	nUDIX hydrolase
HL854_RS01740	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HL854_RS01765	COG4796	Type ii and iii secretion system protein
HL854_RS01780	COG3266	domain, Protein
HL854_RS01785	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HL854_RS01790	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HL854_RS01815	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HL854_RS01820	COG0402	S-adenosylhomocysteine deaminase activity
HL854_RS01825	COG0738	Major facilitator superfamily
HL854_RS01850	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HL854_RS01855	COG1289	transmembrane transporter activity
HL854_RS01865	COG1765	OsmC-like protein
HL854_RS01870	COG3954	Phosphoribulokinase
HL854_RS01880	COG0429	hydrolase of the alpha beta-hydrolase fold
HL854_RS01885	COG0488	(ABC) transporter
HL854_RS01900	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HL854_RS01905	COG1047	Peptidyl-prolyl cis-trans
HL854_RS01915	COG0545	Peptidyl-prolyl cis-trans isomerase
HL854_RS01920	COG2964	Protein conserved in bacteria
HL854_RS01980	COG0051	transcription antitermination factor activity, RNA binding
HL854_RS02005	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HL854_RS02020	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HL854_RS02085	COG0201	protein transport
HL854_RS02100	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HL854_RS02110	COG0202	RNA polymerase activity
HL854_RS02125	COG0789	Transcriptional regulator
HL854_RS02130	COG3036	rescue of stalled ribosome
HL854_RS02160	COG0758	DNA mediated transformation
HL854_RS02170	COG0551	DNA topoisomerase type I activity
HL854_RS02190	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HL854_RS02225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HL854_RS02230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HL854_RS02235	COG1309	transcriptional regulator
HL854_RS02255	COG4145	pantothenate transmembrane transporter activity
HL854_RS02260	COG3924	membrane
HL854_RS02265	COG0439	Biotin carboxylase
HL854_RS02270	COG0511	ligase activity, forming carbon-carbon bonds
HL854_RS02295	COG2200	EAL domain
HL854_RS02295	COG2199	diguanylate cyclase activity
HL854_RS02300	COG1077	Cell shape determining protein MreB Mrl
HL854_RS02305	COG1792	Involved in formation and maintenance of cell shape
HL854_RS02310	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HL854_RS02320	COG1530	ribonuclease E activity
HL854_RS02325	COG3164	Protein of unknown function
HL854_RS02330	COG0312	modulator of DNA gyrase
HL854_RS02335	COG0583	DNA-binding transcription factor activity
HL854_RS02350	COG1289	transmembrane transporter activity
HL854_RS02355	COG2732	(Barnase) inhibitor
HL854_RS02380	COG1802	Transcriptional regulator
HL854_RS02390	COG0471	metal ion transport
HL854_RS02395	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HL854_RS02400	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HL854_RS02410	COG5016	pyruvate
HL854_RS02410	COG0511	ligase activity, forming carbon-carbon bonds
HL854_RS02425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HL854_RS02430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HL854_RS02435	COG3105	Protein conserved in bacteria
HL854_RS02440	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HL854_RS02460	COG0625	glutathione transferase activity
HL854_RS02465	COG2969	positive regulation of protein catabolic process
HL854_RS02475	COG0493	'glutamate synthase
HL854_RS02480	COG0069	glutamate synthase activity
HL854_RS02480	COG0070	glutamate synthase
HL854_RS02480	COG0067	glutamate synthase
HL854_RS02485	COG1242	4 iron, 4 sulfur cluster binding
HL854_RS02490	COG2271	Major facilitator Superfamily
HL854_RS02495	COG1063	alcohol dehydrogenase
HL854_RS02500	COG1312	Catalyzes the dehydration of D-mannonate
HL854_RS02505	COG5002	protein histidine kinase activity
HL854_RS02505	COG2198	Histidine kinase
HL854_RS02505	COG0784	Response regulator, receiver
HL854_RS02510	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HL854_RS02515	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HL854_RS02520	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HL854_RS02530	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HL854_RS02535	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HL854_RS02540	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HL854_RS02545	COG1137	ATPase activity
HL854_RS02550	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HL854_RS02555	COG3117	lipopolysaccharide transmembrane transporter activity
HL854_RS02560	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HL854_RS02570	COG0530	calcium, potassium:sodium antiporter activity
HL854_RS02575	COG1127	ABC transporter
HL854_RS02580	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HL854_RS02585	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HL854_RS02590	COG2854	intermembrane phospholipid transfer
HL854_RS02595	COG3113	response to antibiotic
HL854_RS02600	COG5007	Belongs to the BolA IbaG family
HL854_RS02610	COG3423	Transcriptional regulator
HL854_RS02615	COG0142	geranyltranstransferase activity
HL854_RS02630	COG0697	spore germination
HL854_RS02640	COG2027	D-alanyl-D-alanine carboxypeptidase
HL854_RS02650	COG1534	Rna-binding protein
HL854_RS02660	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HL854_RS02665	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HL854_RS02675	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HL854_RS02715	COG0195	Participates in both transcription termination and antitermination
HL854_RS02760	COG0814	amino acid
HL854_RS02765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL854_RS02770	COG0826	peptidase U32
HL854_RS02775	COG0826	peptidase U32
HL854_RS02780	COG3154	lipid carrier protein
HL854_RS02785	COG3153	acetyltransferase
HL854_RS02800	COG0693	protein deglycase activity
HL854_RS02805	COG0702	epimerase
HL854_RS02810	COG0701	Predicted permease
HL854_RS02815	COG2823	Periplasmic or secreted lipoprotein
HL854_RS02835	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HL854_RS02840	COG2721	sulfolactate sulfo-lyase activity
HL854_RS02850	COG2084	Dehydrogenase
HL854_RS02855	COG1929	Belongs to the glycerate kinase type-1 family
HL854_RS02880	COG1741	Belongs to the pirin family
HL854_RS02885	COG0583	DNA-binding transcription factor activity
HL854_RS02890	COG3152	Membrane
HL854_RS02895	COG0435	Glutathione S-transferase
HL854_RS02900	COG2259	Doxx family
HL854_RS02910	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HL854_RS02915	COG4575	ribosome binding
HL854_RS02920	COG1422	Protein of unknown function (DUF1090)
HL854_RS02930	COG0586	Pfam SNARE associated Golgi protein
HL854_RS02935	COG2186	Transcriptional regulator
HL854_RS02940	COG2271	Major facilitator Superfamily
HL854_RS02950	COG2721	sulfolactate sulfo-lyase activity
HL854_RS02965	COG0861	Integral membrane protein TerC family
HL854_RS02970	COG0673	inositol 2-dehydrogenase activity
HL854_RS02975	COG1451	nucleotide metabolic process
HL854_RS02980	COG3507	Belongs to the glycosyl hydrolase 43 family
HL854_RS02990	COG2211	Major facilitator Superfamily
HL854_RS03000	COG0446	pyridine nucleotide-disulphide oxidoreductase
HL854_RS03000	COG1902	pentaerythritol trinitrate reductase activity
HL854_RS03050	COG1695	Transcriptional regulator
HL854_RS03055	COG2375	cellular response to nickel ion
HL854_RS03070	COG1461	Dihydroxyacetone kinase
HL854_RS03075	COG2376	Dihydroxyacetone kinase
HL854_RS03145	COG3247	response to pH
HL854_RS03155	COG2205	protein histidine kinase activity
HL854_RS03155	COG2198	Histidine kinase
HL854_RS03155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HL854_RS03155	COG0784	Response regulator, receiver
HL854_RS03160	COG2197	response regulator
HL854_RS03175	COG1773	rubredoxin
HL854_RS03175	COG0426	domain, Protein
HL854_RS03190	COG0582	viral genome integration into host DNA
HL854_RS03225	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HL854_RS03265	COG4695	Portal protein
HL854_RS03430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HL854_RS03435	COG0358	DNA primase activity
HL854_RS03440	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HL854_RS03500	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HL854_RS03515	COG4991	sh3 domain protein
HL854_RS03520	COG3025	triphosphatase activity
HL854_RS03545	COG2960	long-chain fatty acid transporting porin activity
HL854_RS03560	COG3384	dioxygenase
HL854_RS03565	COG0754	glutathionylspermidine amidase activity
HL854_RS03580	COG0494	nUDIX hydrolase
HL854_RS03585	COG3151	Protein conserved in bacteria
HL854_RS03590	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HL854_RS03595	COG3150	esterase
HL854_RS03605	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HL854_RS03610	COG2249	NAD(P)H dehydrogenase (quinone) activity
HL854_RS03615	COG0642	Histidine kinase
HL854_RS03625	COG3111	PFAM Bacterial OB fold (BOF) protein
HL854_RS03630	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HL854_RS03635	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HL854_RS03640	COG0204	Acyl-transferase
HL854_RS03645	COG2132	Multicopper oxidase
HL854_RS03650	COG1032	radical SAM domain protein
HL854_RS03655	COG0656	L-ascorbic acid biosynthetic process
HL854_RS03660	COG1979	alcohol dehydrogenase
HL854_RS03665	COG2207	Transcriptional regulator
HL854_RS03670	COG0586	Pfam SNARE associated Golgi protein
HL854_RS03675	COG0626	cystathionine gamma-synthase activity
HL854_RS03685	COG0848	biopolymer transport protein
HL854_RS03705	COG0625	glutathione transferase activity
HL854_RS03720	COG0754	glutathionylspermidine amidase activity
HL854_RS03725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HL854_RS03755	COG0626	cystathionine gamma-synthase activity
HL854_RS03770	COG1811	Na channel or pump
HL854_RS03775	COG1982	Orn Lys Arg decarboxylase major
HL854_RS03780	COG2211	Major facilitator Superfamily
HL854_RS03795	COG1194	a g-specific adenine glycosylase
HL854_RS03805	COG3171	Protein conserved in bacteria
HL854_RS03815	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HL854_RS03830	COG0762	integral membrane protein
HL854_RS03835	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HL854_RS03840	COG2805	Type II/IV secretion system protein
HL854_RS03860	COG0189	ligase activity
HL854_RS03865	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HL854_RS03870	COG2356	endonuclease I
HL854_RS03880	COG2814	Major facilitator Superfamily
HL854_RS03915	COG0501	Belongs to the peptidase M48B family
HL854_RS03920	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HL854_RS03935	COG0191	fructose-bisphosphate aldolase activity
HL854_RS03940	COG0668	transmembrane transport
HL854_RS03950	COG2968	Membrane
HL854_RS03965	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HL854_RS03970	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HL854_RS03990	COG0006	proline dipeptidase activity
HL854_RS03995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HL854_RS04000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HL854_RS04020	COG1028	Short-chain dehydrogenase reductase Sdr
HL854_RS04025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HL854_RS04045	COG2723	6-phospho-beta-galactosidase activity
HL854_RS04050	COG1737	Transcriptional regulator
HL854_RS04060	COG1272	protein, Hemolysin III
HL854_RS04070	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HL854_RS04080	COG0716	FMN binding
HL854_RS04085	COG4974	Belongs to the 'phage' integrase family
HL854_RS04095	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HL854_RS04115	COG4942	peptidase
HL854_RS04125	COG2814	Major facilitator Superfamily
HL854_RS04140	COG0667	Aldo Keto reductase
HL854_RS04145	COG2249	NAD(P)H dehydrogenase (quinone) activity
HL854_RS04180	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HL854_RS04185	COG1393	Belongs to the ArsC family
HL854_RS04190	COG3104	oligopeptide transport
HL854_RS04200	COG1538	Outer membrane efflux protein
HL854_RS04205	COG1289	transmembrane transporter activity
HL854_RS04220	COG3592	Divergent 4Fe-4S mono-cluster
HL854_RS04225	COG2388	GCN5-related N-acetyl-transferase
HL854_RS04235	COG3539	Fimbrial protein
HL854_RS04240	COG3539	Fimbrial protein
HL854_RS04245	COG3539	Fimbrial protein
HL854_RS04250	COG3188	usher protein
HL854_RS04255	COG3121	Chaperone
HL854_RS04260	COG3539	Fimbrial protein
HL854_RS04270	COG4974	Belongs to the 'phage' integrase family
HL854_RS04275	COG0582	viral genome integration into host DNA
HL854_RS04295	COG3121	Chaperone
HL854_RS04300	COG3188	usher protein
HL854_RS04310	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HL854_RS04315	COG1846	Transcriptional regulator
HL854_RS04320	COG0697	spore germination
HL854_RS04370	COG0667	Aldo Keto reductase
HL854_RS04375	COG0814	amino acid
HL854_RS04390	COG0183	Belongs to the thiolase family
HL854_RS04400	COG0823	Involved in the tonB-independent uptake of proteins
HL854_RS04405	COG1028	Short-chain dehydrogenase reductase Sdr
HL854_RS04410	COG2814	Major facilitator Superfamily
HL854_RS04445	COG3842	ATPase activity
HL854_RS04450	COG0395	ABC-type sugar transport system, permease component
HL854_RS04455	COG1175	transmembrane transport
HL854_RS04460	COG1917	Cupin 2, conserved barrel domain protein
HL854_RS04465	COG1794	racemase activity, acting on amino acids and derivatives
HL854_RS04470	COG0583	DNA-binding transcription factor activity
HL854_RS04480	COG1609	Transcriptional regulator
HL854_RS04485	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HL854_RS04490	COG2723	6-phospho-beta-galactosidase activity
HL854_RS04495	COG2186	Transcriptional regulator
HL854_RS04505	COG1609	Transcriptional regulator
HL854_RS04520	COG0667	Aldo Keto reductase
HL854_RS04530	COG0861	Integral membrane protein TerC family
HL854_RS04560	COG2165	general secretion pathway protein
HL854_RS04565	COG4795	General secretion pathway protein
HL854_RS04575	COG4967	type IV pilus modification protein PilV
HL854_RS04580	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HL854_RS04585	COG1025	Belongs to the peptidase M16 family
HL854_RS04590	COG1074	ATP-dependent DNA helicase activity
HL854_RS04595	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HL854_RS04605	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HL854_RS04605	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HL854_RS04610	COG0860	N-Acetylmuramoyl-L-alanine amidase
HL854_RS04615	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HL854_RS04645	COG4656	Part of a membrane complex involved in electron transport
HL854_RS04650	COG1012	belongs to the aldehyde dehydrogenase family
HL854_RS04650	COG1454	alcohol dehydrogenase
HL854_RS04845	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HL854_RS04850	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HL854_RS04855	COG2166	iron-sulfur cluster assembly
HL854_RS04860	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HL854_RS04870	COG0583	DNA-binding transcription factor activity
HL854_RS04875	COG2363	Small membrane protein
HL854_RS04885	COG1349	DNA-binding transcription factor activity
HL854_RS04905	COG0738	Major facilitator superfamily
HL854_RS04910	COG0235	Class ii aldolase
HL854_RS04915	COG1454	alcohol dehydrogenase
HL854_RS04935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL854_RS04950	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HL854_RS04955	COG2011	ABC-type metal ion transport system permease component
HL854_RS04960	COG1464	Belongs to the NlpA lipoprotein family
HL854_RS04965	COG0477	Major facilitator Superfamily
HL854_RS04975	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HL854_RS04980	COG1760	l-serine dehydratase
HL854_RS04985	COG0814	amino acid
HL854_RS04990	COG1611	Belongs to the LOG family
HL854_RS05005	COG3098	single-species biofilm formation
HL854_RS05010	COG0564	pseudouridine synthase activity
HL854_RS05015	COG0716	FMN binding
HL854_RS05020	COG2271	Major facilitator Superfamily
HL854_RS05025	COG4948	Mandelate Racemase Muconate Lactonizing
HL854_RS05030	COG4948	Mandelate Racemase Muconate Lactonizing
HL854_RS05035	COG1929	Belongs to the glycerate kinase type-1 family
HL854_RS05040	COG4999	Histidine kinase
HL854_RS05040	COG3850	Histidine kinase
HL854_RS05040	COG3437	response regulator, receiver
HL854_RS05040	COG2205	protein histidine kinase activity
HL854_RS05050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HL854_RS05055	COG3956	TIGRFAM MazG family protein
HL854_RS05075	COG0602	queuosine metabolic process
HL854_RS05080	COG0720	synthase
HL854_RS05100	COG2234	aminopeptidase activity
HL854_RS05160	COG4942	peptidase
HL854_RS05160	COG1388	LysM domain
HL854_RS05165	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HL854_RS05190	COG0163	prenyltransferase activity
HL854_RS05195	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HL854_RS05235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HL854_RS05240	COG4558	Periplasmic binding protein
HL854_RS05245	COG3720	iron ion transport
HL854_RS05265	COG0679	Auxin Efflux Carrier
HL854_RS05280	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HL854_RS05285	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HL854_RS05290	COG1121	(ABC) transporter
HL854_RS05300	COG1609	Transcriptional regulator
HL854_RS05305	COG1940	carbohydrate kinase activity
HL854_RS05310	COG1447	Phosphotransferase system cellobiose-specific component IIA
HL854_RS05315	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HL854_RS05320	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HL854_RS05325	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HL854_RS05330	COG4580	involved in the transport of maltose and maltodextrins
HL854_RS05340	COG2723	6-phospho-beta-galactosidase activity
HL854_RS05350	COG0309	Hydrogenase expression formation protein (HypE)
HL854_RS05355	COG0409	Hydrogenase expression formation protein
HL854_RS05360	COG0298	carbon dioxide binding
HL854_RS05365	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HL854_RS05380	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HL854_RS05385	COG0651	ATP synthesis coupled electron transport
HL854_RS05390	COG0650	Formate hydrogenlyase subunit 4
HL854_RS05395	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HL854_RS05395	COG3261	NADH dehydrogenase
HL854_RS05400	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL854_RS05405	COG3260	NADH ubiquinone oxidoreductase 20
HL854_RS05415	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HL854_RS05425	COG2723	6-phospho-beta-galactosidase activity
HL854_RS05430	COG1263	PTS System
HL854_RS05430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HL854_RS05435	COG1609	Transcriptional regulator
HL854_RS05440	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HL854_RS05445	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HL854_RS05450	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HL854_RS05475	COG1349	DNA-binding transcription factor activity
HL854_RS05480	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HL854_RS05485	COG1028	Short-chain dehydrogenase reductase Sdr
HL854_RS05495	COG3732	PTS system glucitol sorbitol-specific
HL854_RS05500	COG3730	PTS system glucitol sorbitol-specific
HL854_RS05505	COG2951	lytic endotransglycosylase activity
HL854_RS05510	COG1121	(ABC) transporter
HL854_RS05515	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HL854_RS05520	COG0803	Belongs to the bacterial solute-binding protein 9 family
HL854_RS05525	COG1546	Belongs to the CinA family
HL854_RS05545	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HL854_RS05575	COG2823	Periplasmic or secreted lipoprotein
HL854_RS05580	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HL854_RS05585	COG1238	metal cluster binding
HL854_RS05605	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HL854_RS05610	COG2814	Major facilitator Superfamily
HL854_RS05615	COG1566	PFAM secretion protein HlyD family protein
HL854_RS05620	COG1846	Transcriptional regulator
HL854_RS05630	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HL854_RS05640	COG4176	ABC-type proline glycine betaine transport system permease component
HL854_RS05655	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HL854_RS05665	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HL854_RS05670	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HL854_RS05680	COG4575	ribosome binding
HL854_RS05710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HL854_RS05715	COG0640	Transcriptional regulator
HL854_RS05725	COG0583	DNA-binding transcription factor activity
HL854_RS05730	COG0671	phosphoesterase, PA-phosphatase related
HL854_RS05735	COG3284	Transcriptional regulator
HL854_RS05740	COG1012	belongs to the aldehyde dehydrogenase family
HL854_RS05745	COG3539	Fimbrial protein
HL854_RS05750	COG3121	Chaperone
HL854_RS05785	COG1028	Short-chain dehydrogenase reductase Sdr
HL854_RS05795	COG0235	Class ii aldolase
HL854_RS05800	COG1126	abc transporter atp-binding protein
HL854_RS05805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HL854_RS05835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HL854_RS05885	COG0431	NADPH-dependent FMN reductase
HL854_RS05900	COG2271	Major facilitator Superfamily
HL854_RS05905	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HL854_RS05910	COG0477	Major facilitator Superfamily
HL854_RS05915	COG3622	Belongs to the hyi family
HL854_RS05940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HL854_RS05945	COG2207	Transcriptional regulator
HL854_RS05945	COG3708	Transcriptional regulator
HL854_RS05975	COG2867	negative regulation of translational initiation
HL854_RS05990	COG0497	DNA recombination
HL854_RS06005	COG4536	flavin adenine dinucleotide binding
HL854_RS06010	COG4137	Cytochrome C assembly protein
HL854_RS06015	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HL854_RS06050	COG2885	chlorophyll binding
HL854_RS06055	COG2199	diguanylate cyclase activity
HL854_RS06065	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HL854_RS06070	COG0287	Prephenate dehydrogenase
HL854_RS06070	COG1605	Chorismate mutase
HL854_RS06080	COG0077	Prephenate dehydratase
HL854_RS06080	COG1605	Chorismate mutase
HL854_RS06090	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HL854_RS06095	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HL854_RS06110	COG0542	response to heat
HL854_RS06135	COG0477	Major facilitator Superfamily
HL854_RS06140	COG5544	Lipoprotein
HL854_RS06145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HL854_RS06160	COG3118	belongs to the thioredoxin family
HL854_RS06165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HL854_RS06180	COG0513	Belongs to the DEAD box helicase family
HL854_RS06190	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HL854_RS06205	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HL854_RS06210	COG3026	antisigma factor binding
HL854_RS06215	COG3086	response to oxidative stress
HL854_RS06225	COG0681	Belongs to the peptidase S26 family
HL854_RS06245	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HL854_RS06255	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HL854_RS06260	COG1737	Transcriptional regulator
HL854_RS06265	COG0560	Phosphoserine phosphatase
HL854_RS06280	COG0047	phosphoribosylformylglycinamidine synthase activity
HL854_RS06280	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HL854_RS06285	COG2205	protein histidine kinase activity
HL854_RS06290	COG3170	Tfp pilus assembly protein FimV
HL854_RS06295	COG2204	response regulator
HL854_RS06300	COG0347	Belongs to the P(II) protein family
HL854_RS06305	COG1017	nitric oxide dioxygenase activity
HL854_RS06305	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HL854_RS06315	COG2259	Doxx family
HL854_RS06320	COG2814	Major facilitator Superfamily
HL854_RS06325	COG3711	transcriptional antiterminator
HL854_RS06330	COG3683	transport system, periplasmic component
HL854_RS06335	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HL854_RS06365	COG0822	iron-sulfur transferase activity
HL854_RS06385	COG0633	Ferredoxin
HL854_RS06390	COG2975	iron-sulfur cluster assembly
HL854_RS06410	COG2897	thiosulfate sulfurtransferase activity
HL854_RS06415	COG2373	Large extracellular alpha-helical protein
HL854_RS06420	COG4953	penicillin-binding protein 1C
HL854_RS06450	COG2976	Protein conserved in bacteria
HL854_RS06470	COG1645	bacterial-type flagellum-dependent swarming motility
HL854_RS06480	COG0517	IMP dehydrogenase activity
HL854_RS06480	COG0516	GMP reductase activity
HL854_RS06505	COG2200	EAL domain
HL854_RS06520	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HL854_RS06535	COG2723	6-phospho-beta-galactosidase activity
HL854_RS06545	COG2233	PERMEase
HL854_RS06560	COG1393	Belongs to the ArsC family
HL854_RS06565	COG4783	chaperone-mediated protein folding
HL854_RS06575	COG0628	permease
HL854_RS06580	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HL854_RS06585	COG2716	regulation of RNA biosynthetic process
HL854_RS06595	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HL854_RS06605	COG2321	neutral zinc metallopeptidase
HL854_RS06610	COG1444	tRNA N-acetyltransferase activity
HL854_RS06615	COG0400	carboxylic ester hydrolase activity
HL854_RS06630	COG1393	Belongs to the ArsC family
HL854_RS06640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HL854_RS06645	COG0493	'glutamate synthase
HL854_RS06645	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HL854_RS06655	COG5342	invasion associated locus B
HL854_RS06660	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HL854_RS06665	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HL854_RS06675	COG4810	utilization protein
HL854_RS06705	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HL854_RS06765	COG0860	N-Acetylmuramoyl-L-alanine amidase
HL854_RS06785	COG2837	iron assimilation
HL854_RS06790	COG2852	Protein conserved in bacteria
HL854_RS06795	COG4150	thiosulfate binding
HL854_RS06800	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HL854_RS06805	COG4208	sulfate ABC transporter
HL854_RS06810	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HL854_RS06820	COG4319	ketosteroid isomerase
HL854_RS06855	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HL854_RS06875	COG3530	Putative quorum-sensing-regulated virulence factor
HL854_RS06880	COG0385	Bile acid
HL854_RS06885	COG0583	DNA-binding transcription factor activity
HL854_RS06920	COG3415	Transposase
HL854_RS06925	COG3415	Transposase
HL854_RS06940	COG2199	diguanylate cyclase activity
HL854_RS06940	COG2200	EAL domain
HL854_RS06945	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HL854_RS06960	COG0667	Aldo Keto reductase
HL854_RS06965	COG3961	Belongs to the TPP enzyme family
HL854_RS06980	COG3279	Response regulator of the LytR AlgR family
HL854_RS06985	COG3275	phosphorelay sensor kinase activity
HL854_RS07000	COG0436	Aminotransferase
HL854_RS07010	COG2807	transmembrane transport
HL854_RS07015	COG0590	tRNA wobble adenosine to inosine editing
HL854_RS07020	COG0583	DNA-binding transcription factor activity
HL854_RS07055	COG2885	chlorophyll binding
HL854_RS07175	COG2116	formate transmembrane transporter activity
HL854_RS07180	COG2853	Lipoprotein
HL854_RS07190	COG3691	Protein conserved in bacteria
HL854_RS07205	COG2062	phosphohistidine phosphatase, SixA
HL854_RS07230	COG0730	response to heat
HL854_RS07235	COG3101	peptidyl-lysine hydroxylation
HL854_RS07250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HL854_RS07265	COG2188	Transcriptional regulator
HL854_RS07275	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HL854_RS07280	COG1447	Phosphotransferase system cellobiose-specific component IIA
HL854_RS07300	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HL854_RS07310	COG0586	Pfam SNARE associated Golgi protein
HL854_RS07320	COG0285	dihydrofolate synthase activity
HL854_RS07325	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HL854_RS07330	COG1286	toxin biosynthetic process
HL854_RS07335	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HL854_RS07340	COG0163	prenyltransferase activity
HL854_RS07365	COG4160	amino acid transport
HL854_RS07370	COG4598	ABC transporter
HL854_RS07385	COG1090	epimerase
HL854_RS07390	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HL854_RS07395	COG0625	glutathione transferase activity
HL854_RS07400	COG0625	glutathione transferase activity
HL854_RS07405	COG0622	Phosphoesterase
HL854_RS07410	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HL854_RS07435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HL854_RS07440	COG0471	metal ion transport
HL854_RS07440	COG0490	domain, Protein
HL854_RS07450	COG0436	Aminotransferase
HL854_RS07455	COG0583	DNA-binding transcription factor activity
HL854_RS07500	COG0839	Belongs to the complex I subunit 6 family
HL854_RS07510	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HL854_RS07515	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL854_RS07530	COG2153	protein acetylation
HL854_RS07535	COG1169	isochorismate synthase
HL854_RS07560	COG0318	PFAM AMP-dependent synthetase and ligase
HL854_RS07570	COG5464	transposase or invertase
HL854_RS07585	COG1414	Transcriptional regulator
HL854_RS07595	COG2271	Major facilitator Superfamily
HL854_RS07605	COG0247	lactate metabolic process
HL854_RS07615	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HL854_RS07620	COG2271	Major facilitator Superfamily
HL854_RS07625	COG0584	glycerophosphoryl diester phosphodiesterase
HL854_RS07630	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HL854_RS07665	COG0642	Histidine kinase
HL854_RS07665	COG2198	Histidine kinase
HL854_RS07680	COG2169	Transcriptional regulator
HL854_RS07680	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HL854_RS07685	COG3145	DNA-N1-methyladenine dioxygenase activity
HL854_RS07690	COG4615	Cyclic peptide transporter
HL854_RS07695	COG2239	Acts as a magnesium transporter
HL854_RS07700	COG0659	secondary active sulfate transmembrane transporter activity
HL854_RS07715	COG0628	permease
HL854_RS07730	COG1126	abc transporter atp-binding protein
HL854_RS07735	COG0765	amino acid transport
HL854_RS07740	COG0765	amino acid transport
HL854_RS07755	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HL854_RS07780	COG1349	DNA-binding transcription factor activity
HL854_RS07785	COG0494	nUDIX hydrolase
HL854_RS07805	COG1061	Type III restriction enzyme res subunit
HL854_RS07810	COG1187	pseudouridine synthase activity
HL854_RS07815	COG2814	Major facilitator Superfamily
HL854_RS07825	COG4172	Belongs to the ABC transporter superfamily
HL854_RS07830	COG4239	(ABC) transporter, permease
HL854_RS07835	COG4174	ABC transporter (Permease)
HL854_RS07840	COG4166	transmembrane transport
HL854_RS07845	COG2200	EAL domain
HL854_RS07850	COG0791	NLP P60 protein
HL854_RS07855	COG0671	phosphoesterase, PA-phosphatase related
HL854_RS07860	COG0523	cobalamin synthesis protein
HL854_RS07865	COG0246	Mannitol dehydrogenase
HL854_RS07870	COG1312	Catalyzes the dehydration of D-mannonate
HL854_RS07895	COG1566	PFAM secretion protein HlyD family protein
HL854_RS07900	COG2814	Major facilitator Superfamily
HL854_RS07905	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HL854_RS07905	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HL854_RS07910	COG1105	Belongs to the carbohydrate kinase PfkB family
HL854_RS07915	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HL854_RS07915	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HL854_RS07915	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HL854_RS07925	COG2855	membrane
HL854_RS07930	COG0583	DNA-binding transcription factor activity
HL854_RS07935	COG0833	amino acid
HL854_RS07940	COG4771	TonB-dependent receptor
HL854_RS07955	COG2311	Membrane
HL854_RS07970	COG1129	ABC transporter
HL854_RS07990	COG2949	membrane
HL854_RS08000	COG1346	cytolysis
HL854_RS08010	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HL854_RS08015	COG3659	wide pore channel activity
HL854_RS08030	COG2723	6-phospho-beta-galactosidase activity
HL854_RS08040	COG1538	Outer membrane efflux protein
HL854_RS08045	COG0586	Pfam SNARE associated Golgi protein
HL854_RS08055	COG1686	Belongs to the peptidase S11 family
HL854_RS08065	COG0277	FAD linked oxidase domain protein
HL854_RS08070	COG1472	Belongs to the glycosyl hydrolase 3 family
HL854_RS08075	COG1732	Glycine betaine
HL854_RS08080	COG1174	glycine betaine transport
HL854_RS08085	COG1125	glycine betaine transport
HL854_RS08090	COG1174	glycine betaine transport
HL854_RS08100	COG3275	phosphorelay sensor kinase activity
HL854_RS08110	COG4807	Protein conserved in bacteria
HL854_RS08130	COG5455	response to cobalt ion
HL854_RS08135	COG0583	DNA-binding transcription factor activity
HL854_RS08140	COG2252	PERMEase
HL854_RS08150	COG0583	DNA-binding transcription factor activity
HL854_RS08165	COG0351	phosphomethylpyrimidine kinase
HL854_RS08170	COG1830	Aldolase
HL854_RS08185	COG1070	Carbohydrate kinase
HL854_RS08195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HL854_RS08200	COG4948	Mandelate Racemase Muconate Lactonizing
HL854_RS08205	COG0747	negative chemotaxis
HL854_RS08210	COG0601	transmembrane transport
HL854_RS08220	COG0444	Belongs to the ABC transporter superfamily
HL854_RS08225	COG4608	Belongs to the ABC transporter superfamily
HL854_RS08240	COG0745	RESPONSE REGULATOR receiver
HL854_RS08245	COG2205	protein histidine kinase activity
HL854_RS08270	COG1301	dicarboxylic acid transport
HL854_RS08285	COG0745	RESPONSE REGULATOR receiver
HL854_RS08290	COG5002	protein histidine kinase activity
HL854_RS08295	COG0443	Heat shock 70 kDa protein
HL854_RS08300	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HL854_RS08315	COG2982	Protein involved in outer membrane biogenesis
HL854_RS08320	COG1253	flavin adenine dinucleotide binding
HL854_RS08355	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HL854_RS08360	COG2244	polysaccharide biosynthetic process
HL854_RS08365	COG0438	transferase activity, transferring glycosyl groups
HL854_RS08390	COG0438	transferase activity, transferring glycosyl groups
HL854_RS08460	COG0438	transferase activity, transferring glycosyl groups
HL854_RS08485	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HL854_RS08515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HL854_RS08520	COG0583	DNA-binding transcription factor activity
HL854_RS08530	COG0531	amino acid
HL854_RS08545	COG3604	Transcriptional regulator
HL854_RS08550	COG2205	protein histidine kinase activity
HL854_RS08635	COG0640	Transcriptional regulator
HL854_RS08640	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HL854_RS08645	COG2925	Exonuclease
HL854_RS08660	COG1289	transmembrane transporter activity
HL854_RS08680	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HL854_RS08690	COG1942	4-Oxalocrotonate Tautomerase
HL854_RS08695	COG0583	DNA-binding transcription factor activity
HL854_RS08700	COG0095	Lipoate-protein ligase
HL854_RS08705	COG0477	Major facilitator Superfamily
HL854_RS08715	COG5001	Diguanylate cyclase
HL854_RS08715	COG3300	MHYT domain
HL854_RS08720	COG3615	Tellurite resistance protein tehB
HL854_RS08745	COG3706	GGDEF domain
HL854_RS08770	COG0534	Mate efflux family protein
HL854_RS08780	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HL854_RS08800	COG0604	alcohol dehydrogenase
HL854_RS08805	COG1309	transcriptional regulator
HL854_RS08810	COG0025	NhaP-type Na H and K H
HL854_RS08815	COG1045	serine acetyltransferase
HL854_RS08820	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HL854_RS08840	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HL854_RS08845	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HL854_RS08895	COG1028	Short-chain dehydrogenase reductase Sdr
HL854_RS08905	COG0523	cobalamin synthesis protein
HL854_RS08930	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HL854_RS08940	COG1418	mRNA catabolic process
HL854_RS08945	COG0270	DNA (cytosine-5-)-methyltransferase activity
HL854_RS08950	COG3727	T/G mismatch-specific endonuclease activity
HL854_RS08955	COG0697	spore germination
HL854_RS08960	COG2354	Protein conserved in bacteria
HL854_RS08990	COG0366	Alpha amylase catalytic
HL854_RS09015	COG2197	response regulator
HL854_RS09025	COG2197	response regulator
HL854_RS09065	COG3012	SEC-C Motif Domain Protein
HL854_RS09065	COG3318	Belongs to the UPF0149 family
HL854_RS09070	COG0814	amino acid
HL854_RS09080	COG1528	Iron-storage protein
HL854_RS09095	COG0477	Major facilitator Superfamily
HL854_RS09105	COG2211	Major facilitator Superfamily
HL854_RS09110	COG1528	Iron-storage protein
HL854_RS09115	COG1879	ABC-type sugar transport system periplasmic component
HL854_RS09125	COG1172	Belongs to the binding-protein-dependent transport system permease family
HL854_RS09150	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HL854_RS09160	COG3102	Protein conserved in bacteria
HL854_RS09180	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HL854_RS09185	COG1801	Protein of unknown function DUF72
HL854_RS09190	COG1335	isochorismatase
HL854_RS09200	COG0494	nUDIX hydrolase
HL854_RS09225	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HL854_RS09235	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HL854_RS09240	COG0739	heme binding
HL854_RS09245	COG1560	Kdo2-lipid A biosynthetic process
HL854_RS09265	COG3493	citrate carrier protein
HL854_RS09275	COG1737	Transcriptional regulator
HL854_RS09285	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HL854_RS09290	COG0129	dihydroxy-acid dehydratase activity
HL854_RS09295	COG0800	Aldolase
HL854_RS09305	COG3141	response to X-ray
HL854_RS09310	COG2979	Protein of unknown function (DUF533)
HL854_RS09315	COG1770	oligopeptidase
HL854_RS09320	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HL854_RS09330	COG2372	response to copper ion
HL854_RS09335	COG1276	copper resistance
HL854_RS09350	COG2990	Protein conserved in bacteria
HL854_RS09375	COG3008	intermembrane lipid transfer
HL854_RS09380	COG2995	paraquat-inducible protein a
HL854_RS09385	COG1956	GAF domain-containing protein
HL854_RS09405	COG2814	Major facilitator Superfamily
HL854_RS09410	COG1414	Transcriptional regulator
HL854_RS09445	COG0768	penicillin binding
HL854_RS09450	COG2226	methyltransferase
HL854_RS09465	COG3716	PTS system mannose fructose sorbose family IID component
HL854_RS09470	COG3715	PTS system
HL854_RS09475	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HL854_RS09475	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HL854_RS09480	COG1253	flavin adenine dinucleotide binding
HL854_RS09485	COG2200	EAL domain
HL854_RS09490	COG1760	l-serine dehydratase
HL854_RS09520	COG1653	transport
HL854_RS09525	COG1175	transmembrane transport
HL854_RS09530	COG0395	ABC-type sugar transport system, permease component
HL854_RS09535	COG3842	ATPase activity
HL854_RS09545	COG0251	oxidation-reduction process
HL854_RS09550	COG1199	ATP-dependent helicase activity
HL854_RS09560	COG3065	identical protein binding
HL854_RS09570	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HL854_RS09580	COG2894	cell division
HL854_RS09595	COG0179	Fumarylacetoacetate (FAA) hydrolase
HL854_RS09625	COG2719	SpoVR family
HL854_RS09650	COG1619	proteins homologs of microcin C7 resistance protein MccF
HL854_RS09670	COG4774	siderophore transport
HL854_RS09685	COG2308	Evidence 4 Homologs of previously reported genes of
HL854_RS09705	COG3842	ATPase activity
HL854_RS09710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HL854_RS09715	COG0395	ABC-type sugar transport system, permease component
HL854_RS09730	COG1940	carbohydrate kinase activity
HL854_RS09745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL854_RS09755	COG1174	glycine betaine transport
HL854_RS09775	COG0583	DNA-binding transcription factor activity
HL854_RS09780	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HL854_RS09795	COG1882	Formate acetyltransferase
HL854_RS09830	COG0583	DNA-binding transcription factor activity
HL854_RS09860	COG0583	DNA-binding transcription factor activity
HL854_RS09870	COG0564	pseudouridine synthase activity
HL854_RS09875	COG3122	Protein conserved in bacteria
HL854_RS09880	COG2186	Transcriptional regulator
HL854_RS09885	COG3734	2-keto-3-deoxy-galactonokinase
HL854_RS09890	COG0800	Aldolase
HL854_RS09905	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HL854_RS09940	COG0012	GTP binding
HL854_RS09960	COG0659	secondary active sulfate transmembrane transporter activity
HL854_RS09990	COG2890	protein-(glutamine-N5) methyltransferase activity
HL854_RS10010	COG0387	Pfam Sodium calcium exchanger
HL854_RS10015	COG4572	Cation transport regulator
HL854_RS10020	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HL854_RS10030	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HL854_RS10035	COG3707	response regulator
HL854_RS10040	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HL854_RS10050	COG1116	anion transmembrane transporter activity
HL854_RS10055	COG2146	nitrite reductase [NAD(P)H] activity
HL854_RS10055	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HL854_RS10060	COG0243	molybdopterin cofactor binding
HL854_RS10065	COG4932	domain protein
HL854_RS10070	COG2197	response regulator
HL854_RS10075	COG3850	Histidine kinase
HL854_RS10080	COG2223	nitrite transmembrane transporter activity
HL854_RS10085	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HL854_RS10090	COG1140	nitrate reductase beta subunit
HL854_RS10095	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HL854_RS10100	COG2181	nitrate reductase activity
HL854_RS10110	COG1522	sequence-specific DNA binding
HL854_RS10140	COG0788	formyltetrahydrofolate deformylase activity
HL854_RS10150	COG1752	Esterase of the alpha-beta hydrolase superfamily
HL854_RS10155	COG0745	RESPONSE REGULATOR receiver
HL854_RS10160	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HL854_RS10165	COG2916	Histone family protein nucleoid-structuring protein H-NS
HL854_RS10170	COG1435	thymidine kinase activity
HL854_RS10175	COG1012	belongs to the aldehyde dehydrogenase family
HL854_RS10175	COG1454	alcohol dehydrogenase
HL854_RS10185	COG2095	MarC family integral membrane protein
HL854_RS10190	COG4166	transmembrane transport
HL854_RS10195	COG0601	transmembrane transport
HL854_RS10200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HL854_RS10205	COG0444	Belongs to the ABC transporter superfamily
HL854_RS10215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HL854_RS10235	COG2353	YceI-like domain
HL854_RS10240	COG4993	Dehydrogenase
HL854_RS10245	COG2350	Protein conserved in bacteria
HL854_RS10255	COG3001	Fructosamine kinase
HL854_RS10265	COG1105	Belongs to the carbohydrate kinase PfkB family
HL854_RS10270	COG3137	Salt-induced outer membrane protein
HL854_RS10310	COG0072	phenylalanine-tRNA ligase activity
HL854_RS10310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HL854_RS10320	COG0251	oxidation-reduction process
HL854_RS10330	COG0583	DNA-binding transcription factor activity
HL854_RS10350	COG0386	Belongs to the glutathione peroxidase family
HL854_RS10360	COG0791	NLP P60 protein
HL854_RS10370	COG4256	Hemin uptake protein
HL854_RS10375	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HL854_RS10390	COG0574	Belongs to the PEP-utilizing enzyme family
HL854_RS10390	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HL854_RS10400	COG0628	permease
HL854_RS10405	COG0247	lactate metabolic process
HL854_RS10405	COG0277	FAD linked oxidase domain protein
HL854_RS10410	COG2050	protein possibly involved in aromatic compounds catabolism
HL854_RS10415	COG2261	transglycosylase associated protein
HL854_RS10440	COG1120	ATPase activity
HL854_RS10445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HL854_RS10455	COG0583	DNA-binding transcription factor activity
HL854_RS10480	COG1304	FMN binding
HL854_RS10490	COG0316	Belongs to the HesB IscA family
HL854_RS10495	COG0719	Fe-S assembly protein
HL854_RS10500	COG0396	ATPase activity
HL854_RS10505	COG0719	Fe-S assembly protein
HL854_RS10520	COG1376	ErfK ybiS ycfS ynhG family protein
HL854_RS10545	COG1309	transcriptional regulator
HL854_RS10555	COG2271	Major facilitator Superfamily
HL854_RS10560	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HL854_RS10585	COG1414	Transcriptional regulator
HL854_RS10620	COG2814	Major facilitator Superfamily
HL854_RS10640	COG0583	DNA-binding transcription factor activity
HL854_RS10645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL854_RS10665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HL854_RS10670	COG1116	anion transmembrane transporter activity
HL854_RS10675	COG4774	siderophore transport
HL854_RS10680	COG1120	ATPase activity
HL854_RS10685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HL854_RS10690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HL854_RS10710	COG0765	amino acid transport
HL854_RS10715	COG1126	abc transporter atp-binding protein
HL854_RS10740	COG0641	radical SAM
HL854_RS10745	COG3119	arylsulfatase activity
HL854_RS10755	COG1116	anion transmembrane transporter activity
HL854_RS10775	COG0346	lactoylglutathione lyase activity
HL854_RS10785	COG1121	(ABC) transporter
HL854_RS10805	COG2814	Major facilitator Superfamily
HL854_RS10810	COG0860	N-Acetylmuramoyl-L-alanine amidase
HL854_RS10845	COG3383	formate dehydrogenase (NAD+) activity
HL854_RS10850	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HL854_RS10860	COG1175	transmembrane transport
HL854_RS10890	COG4133	protoheme IX ABC transporter activity
HL854_RS10895	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HL854_RS10900	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HL854_RS10915	COG1138	Cytochrome C-type biogenesis protein
HL854_RS10920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HL854_RS10925	COG3088	subunit of a heme lyase
HL854_RS10925	COG4235	cytochrome complex assembly
HL854_RS10955	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HL854_RS10975	COG0583	DNA-binding transcription factor activity
HL854_RS11005	COG1028	Short-chain dehydrogenase reductase Sdr
HL854_RS11010	COG2610	gluconate transmembrane transporter activity
HL854_RS11015	COG1250	3-hydroxyacyl-CoA dehydrogenase
HL854_RS11025	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HL854_RS11035	COG0583	DNA-binding transcription factor activity
HL854_RS11065	COG2814	Major facilitator Superfamily
HL854_RS11110	COG0277	FAD linked oxidase domain protein
HL854_RS11115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HL854_RS11140	COG0402	S-adenosylhomocysteine deaminase activity
HL854_RS11175	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HL854_RS11185	COG1028	Short-chain dehydrogenase reductase Sdr
HL854_RS11190	COG0531	amino acid
HL854_RS11195	COG0583	DNA-binding transcription factor activity
HL854_RS11220	COG4608	Belongs to the ABC transporter superfamily
HL854_RS11225	COG0444	Belongs to the ABC transporter superfamily
HL854_RS11255	COG2011	ABC-type metal ion transport system permease component
HL854_RS11270	COG0346	lactoylglutathione lyase activity
HL854_RS11275	COG1349	DNA-binding transcription factor activity
HL854_RS11315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HL854_RS11335	COG0300	oxidoreductase activity
HL854_RS11375	COG0307	riboflavin synthase, alpha
HL854_RS11380	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HL854_RS11385	COG2814	Major facilitator Superfamily
HL854_RS11390	COG0583	DNA-binding transcription factor activity
HL854_RS11405	COG2814	Major facilitator Superfamily
HL854_RS11415	COG2207	Transcriptional regulator
HL854_RS11420	COG0791	NLP P60 protein
HL854_RS11425	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HL854_RS11435	COG0346	lactoylglutathione lyase activity
HL854_RS11440	COG1902	pentaerythritol trinitrate reductase activity
HL854_RS11445	COG1309	transcriptional regulator
HL854_RS11450	COG3313	Fe-S protein
HL854_RS11455	COG4989	oxidoreductase activity
HL854_RS11460	COG2032	superoxide dismutase activity
HL854_RS11465	COG1289	transmembrane transporter activity
HL854_RS11470	COG1566	PFAM secretion protein HlyD family protein
HL854_RS11485	COG3706	GGDEF domain
HL854_RS11500	COG3895	Periplasmic Protein
HL854_RS11515	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HL854_RS11520	COG0625	glutathione transferase activity
HL854_RS11530	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HL854_RS11540	COG4659	FMN binding
HL854_RS11575	COG2723	6-phospho-beta-galactosidase activity
HL854_RS11585	COG0673	inositol 2-dehydrogenase activity
HL854_RS11595	COG2814	Major facilitator Superfamily
HL854_RS11615	COG3038	cytochrome b561
HL854_RS11635	COG0583	DNA-binding transcription factor activity
HL854_RS11640	COG3485	protocatechuate 3,4-dioxygenase
HL854_RS11645	COG3485	protocatechuate 3,4-dioxygenase
HL854_RS11650	COG5383	Protein conserved in bacteria
HL854_RS11655	COG2272	Belongs to the type-B carboxylesterase lipase family
HL854_RS11670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HL854_RS11675	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HL854_RS11680	COG1275	C4-dicarboxylate transporter malic acid transport protein
HL854_RS11685	COG0500	methyltransferase
HL854_RS11700	COG2207	Transcriptional regulator
HL854_RS11700	COG3708	Transcriptional regulator
HL854_RS11705	COG3135	benzoate transporter
HL854_RS11710	COG1396	sequence-specific DNA binding
HL854_RS11720	COG0826	peptidase U32
HL854_RS11740	COG1294	oxidase, subunit
HL854_RS11745	COG1271	oxidase subunit
HL854_RS11750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HL854_RS11755	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HL854_RS11760	COG3842	ATPase activity
HL854_RS11765	COG1176	ABC-type spermidine putrescine transport system, permease component I
HL854_RS11770	COG1177	transmembrane transport
HL854_RS11775	COG1012	belongs to the aldehyde dehydrogenase family
HL854_RS11805	COG1012	belongs to the aldehyde dehydrogenase family
HL854_RS11810	COG0747	negative chemotaxis
HL854_RS11820	COG3238	Protein conserved in bacteria
HL854_RS11825	COG1247	-acetyltransferase
HL854_RS11835	COG2130	NADP-dependent
HL854_RS11850	COG3691	Protein conserved in bacteria
HL854_RS11855	COG4772	TonB-dependent receptor
HL854_RS11880	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HL854_RS11885	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HL854_RS11890	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HL854_RS11895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL854_RS11900	COG1473	amidohydrolase
HL854_RS11905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL854_RS11920	COG0765	amino acid transport
HL854_RS11925	COG1126	abc transporter atp-binding protein
HL854_RS11935	COG2271	Major facilitator Superfamily
HL854_RS11945	COG1609	Transcriptional regulator
HL854_RS11950	COG0625	glutathione transferase activity
HL854_RS11980	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HL854_RS11985	COG3842	ATPase activity
HL854_RS11990	COG1840	ABC-type Fe3 transport system, periplasmic component
HL854_RS11995	COG1178	ABC-type Fe3 transport system permease component
HL854_RS12000	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HL854_RS12005	COG2181	nitrate reductase activity
HL854_RS12010	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HL854_RS12015	COG1140	nitrate reductase beta subunit
HL854_RS12020	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HL854_RS12040	COG1414	Transcriptional regulator
HL854_RS12045	COG4948	Mandelate Racemase Muconate Lactonizing
HL854_RS12050	COG4829	muconolactone delta-isomerase
HL854_RS12055	COG3485	protocatechuate 3,4-dioxygenase
HL854_RS12065	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HL854_RS12090	COG0437	4 iron, 4 sulfur cluster binding
HL854_RS12095	COG2864	formate dehydrogenase
HL854_RS12110	COG2326	polyphosphate kinase activity
HL854_RS12120	COG2814	Major facilitator Superfamily
HL854_RS12130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL854_RS12145	COG0601	transmembrane transport
HL854_RS12150	COG0747	negative chemotaxis
HL854_RS12155	COG1064	alcohol dehydrogenase
HL854_RS12170	COG0488	(ABC) transporter
HL854_RS12230	COG1028	Short-chain dehydrogenase reductase Sdr
HL854_RS12235	COG3729	General stress protein
HL854_RS12245	COG3685	Protein conserved in bacteria
HL854_RS12255	COG0366	Alpha amylase catalytic
HL854_RS12265	COG2323	membrane
HL854_RS12275	COG3111	PFAM Bacterial OB fold (BOF) protein
HL854_RS12285	COG1764	response to oxidative stress
HL854_RS12300	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HL854_RS12305	COG3781	membrane
HL854_RS12310	COG0243	molybdopterin cofactor binding
HL854_RS12315	COG0583	DNA-binding transcription factor activity
HL854_RS12320	COG2814	Major facilitator Superfamily
HL854_RS12325	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HL854_RS12345	COG0519	Catalyzes the synthesis of GMP from XMP
HL854_RS12345	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HL854_RS12385	COG0596	Alpha beta hydrolase
HL854_RS12390	COG0745	RESPONSE REGULATOR receiver
HL854_RS12395	COG2205	protein histidine kinase activity
HL854_RS12410	COG0076	glutamate decarboxylase activity
HL854_RS12415	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HL854_RS12420	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HL854_RS12425	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HL854_RS12430	COG1116	anion transmembrane transporter activity
HL854_RS12435	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HL854_RS12455	COG0673	inositol 2-dehydrogenase activity
HL854_RS12465	COG1609	Transcriptional regulator
HL854_RS12470	COG3706	GGDEF domain
HL854_RS12480	COG0402	S-adenosylhomocysteine deaminase activity
HL854_RS12485	COG1953	Uracil, thiamine, allantoin
HL854_RS12530	COG2207	Transcriptional regulator
HL854_RS12545	COG0583	DNA-binding transcription factor activity
HL854_RS12580	COG0583	DNA-binding transcription factor activity
HL854_RS12595	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HL854_RS12675	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HL854_RS12685	COG2070	2-Nitropropane dioxygenase
HL854_RS12690	COG0583	DNA-binding transcription factor activity
HL854_RS12700	COG1902	pentaerythritol trinitrate reductase activity
HL854_RS12705	COG4529	Protein conserved in bacteria
HL854_RS12710	COG0477	Major facilitator Superfamily
HL854_RS12740	COG2223	nitrite transmembrane transporter activity
HL854_RS12755	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HL854_RS12765	COG3665	Urea carboxylase-associated protein
HL854_RS12770	COG0439	Biotin carboxylase
HL854_RS12785	COG1028	Short-chain dehydrogenase reductase Sdr
HL854_RS12790	COG0583	DNA-binding transcription factor activity
HL854_RS12795	COG1609	Transcriptional regulator
HL854_RS12800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HL854_RS12810	COG3037	sugar-specific permease SgaT UlaA
HL854_RS12815	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HL854_RS12825	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HL854_RS12840	COG2197	response regulator
HL854_RS12885	COG0583	DNA-binding transcription factor activity
HL854_RS12890	COG0583	DNA-binding transcription factor activity
HL854_RS12895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HL854_RS12905	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HL854_RS12920	COG1172	Belongs to the binding-protein-dependent transport system permease family
HL854_RS12930	COG1609	Transcriptional regulator
HL854_RS12955	COG0747	negative chemotaxis
HL854_RS12960	COG0601	transmembrane transport
HL854_RS12975	COG2814	Major facilitator Superfamily
HL854_RS12980	COG1566	PFAM secretion protein HlyD family protein
HL854_RS13010	COG1979	alcohol dehydrogenase
HL854_RS13015	COG4977	sequence-specific DNA binding
HL854_RS13025	COG1979	alcohol dehydrogenase
HL854_RS13030	COG1064	alcohol dehydrogenase
HL854_RS13045	COG4977	sequence-specific DNA binding
HL854_RS13060	COG3850	Histidine kinase
HL854_RS13060	COG5002	protein histidine kinase activity
HL854_RS13145	COG2186	Transcriptional regulator
HL854_RS13150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HL854_RS13150	COG1263	PTS System
HL854_RS13160	COG2814	Major facilitator Superfamily
HL854_RS13165	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HL854_RS13165	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HL854_RS13180	COG2819	hydrolase of the alpha beta superfamily
HL854_RS13185	COG3300	MHYT domain
HL854_RS13185	COG5001	Diguanylate cyclase
HL854_RS13205	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HL854_RS13240	COG3188	usher protein
HL854_RS13255	COG3550	peptidyl-serine autophosphorylation
HL854_RS13260	COG1396	sequence-specific DNA binding
HL854_RS13265	COG2351	hydroxyisourate hydrolase activity
HL854_RS13275	COG2233	PERMEase
HL854_RS13305	COG2207	Transcriptional regulator
HL854_RS13320	COG4628	conserved protein (DUF2132)
HL854_RS13340	COG2011	ABC-type metal ion transport system permease component
HL854_RS13345	COG2070	2-Nitropropane dioxygenase
HL854_RS13355	COG0477	Major facilitator Superfamily
HL854_RS13410	COG2199	diguanylate cyclase activity
HL854_RS13425	COG1012	belongs to the aldehyde dehydrogenase family
HL854_RS13430	COG0583	DNA-binding transcription factor activity
HL854_RS13440	COG0039	L-malate dehydrogenase activity
HL854_RS13445	COG1349	DNA-binding transcription factor activity
HL854_RS13450	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HL854_RS13455	COG3395	kinase activity
HL854_RS13465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HL854_RS13480	COG2731	YhcH YjgK YiaL family protein
HL854_RS13485	COG1028	Short-chain dehydrogenase reductase Sdr
HL854_RS13510	COG4977	sequence-specific DNA binding
HL854_RS13520	COG0697	spore germination
HL854_RS13525	COG2814	Major facilitator Superfamily
HL854_RS13555	COG0683	leucine binding
HL854_RS13560	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HL854_RS13595	COG2223	nitrite transmembrane transporter activity
HL854_RS13600	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HL854_RS13615	COG1349	DNA-binding transcription factor activity
HL854_RS13620	COG2084	Dehydrogenase
HL854_RS13625	COG3395	kinase activity
HL854_RS13630	COG0235	Class ii aldolase
HL854_RS13635	COG3622	Belongs to the hyi family
HL854_RS13640	COG2610	gluconate transmembrane transporter activity
HL854_RS13645	COG3708	Transcriptional regulator
HL854_RS13645	COG2207	Transcriptional regulator
HL854_RS13660	COG2200	EAL domain
HL854_RS13665	COG1546	Belongs to the CinA family
HL854_RS13670	COG0071	Belongs to the small heat shock protein (HSP20) family
HL854_RS13730	COG0583	DNA-binding transcription factor activity
HL854_RS13740	COG0406	alpha-ribazole phosphatase activity
HL854_RS13745	COG0583	DNA-binding transcription factor activity
HL854_RS13800	COG4221	oxidoreductase activity
HL854_RS13805	COG1802	Transcriptional regulator
HL854_RS13810	COG0589	response to stress
HL854_RS13815	COG0246	Mannitol dehydrogenase
HL854_RS13820	COG2271	Major facilitator Superfamily
HL854_RS13835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HL854_RS13850	COG0243	molybdopterin cofactor binding
HL854_RS13855	COG0437	4 iron, 4 sulfur cluster binding
HL854_RS13860	COG3302	dmso reductase anchor subunit
HL854_RS13875	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HL854_RS13880	COG1940	carbohydrate kinase activity
HL854_RS13885	COG0583	DNA-binding transcription factor activity
HL854_RS13890	COG2814	Major facilitator Superfamily
HL854_RS13895	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HL854_RS13910	COG3591	Belongs to the peptidase S1B family
HL854_RS13930	COG0628	permease
HL854_RS13960	COG0679	Auxin Efflux Carrier
HL854_RS13970	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HL854_RS13980	COG2814	Major facilitator Superfamily
HL854_RS13995	COG3290	protein histidine kinase activity
HL854_RS14000	COG4565	transcriptional regulatory protein
HL854_RS14020	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HL854_RS14020	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HL854_RS14030	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HL854_RS14035	COG0596	Alpha beta hydrolase
HL854_RS14045	COG0183	Belongs to the thiolase family
HL854_RS14050	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HL854_RS14060	COG1414	Transcriptional regulator
HL854_RS14065	COG2840	Smr protein MutS2
HL854_RS14070	COG0583	DNA-binding transcription factor activity
HL854_RS14080	COG1473	amidohydrolase
HL854_RS14085	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HL854_RS14230	COG1783	phage Terminase large subunit
HL854_RS14250	COG3772	lysozyme
HL854_RS14335	COG1846	Transcriptional regulator
HL854_RS14400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HL854_RS14415	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HL854_RS14420	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HL854_RS14435	COG0531	amino acid
HL854_RS14445	COG3136	membrane protein required for alginate biosynthesis
HL854_RS14450	COG0745	RESPONSE REGULATOR receiver
HL854_RS14465	COG2205	protein histidine kinase activity
HL854_RS14475	COG0114	fumarate hydratase activity
HL854_RS14480	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HL854_RS14480	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HL854_RS14485	COG1482	cell wall glycoprotein biosynthetic process
HL854_RS14490	COG5339	Protein conserved in bacteria
HL854_RS14495	COG1609	Transcriptional regulator
HL854_RS14500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HL854_RS14500	COG1263	PTS System
HL854_RS14505	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HL854_RS14535	COG0425	Belongs to the sulfur carrier protein TusA family
HL854_RS14540	COG5562	phage envelope protein
HL854_RS14545	COG0401	homolog of Blt101
HL854_RS14550	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HL854_RS14555	COG1012	belongs to the aldehyde dehydrogenase family
HL854_RS14565	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HL854_RS14570	COG0477	Major facilitator Superfamily
HL854_RS14575	COG1113	amino acid transport
HL854_RS14580	COG2988	succinylglutamate desuccinylase activity
HL854_RS14585	COG3724	N-succinylarginine dihydrolase activity
HL854_RS14590	COG1012	belongs to the aldehyde dehydrogenase family
HL854_RS14595	COG3138	arginine N-succinyltransferase
HL854_RS14600	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HL854_RS14610	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HL854_RS14625	COG0183	Belongs to the thiolase family
HL854_RS14635	COG0667	Aldo Keto reductase
HL854_RS14640	COG2814	Major facilitator Superfamily
HL854_RS14645	COG0667	Aldo Keto reductase
HL854_RS14650	COG0583	DNA-binding transcription factor activity
HL854_RS14675	COG4122	O-methyltransferase activity
HL854_RS14685	COG1643	Atp-dependent helicase
HL854_RS14695	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HL854_RS14705	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HL854_RS14710	COG3327	negative regulation of DNA-templated transcription, initiation
HL854_RS14715	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HL854_RS14720	COG0183	Belongs to the thiolase family
HL854_RS14725	COG2050	protein possibly involved in aromatic compounds catabolism
HL854_RS14730	COG1250	3-hydroxyacyl-CoA dehydrogenase
HL854_RS14735	COG1024	Enoyl-CoA hydratase
HL854_RS14740	COG1024	Enoyl-CoA hydratase
HL854_RS14745	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HL854_RS14750	COG2151	metal-sulfur cluster biosynthetic enzyme
HL854_RS14755	COG3396	Phenylacetate-CoA oxygenase
HL854_RS14760	COG3460	Phenylacetate-CoA oxygenase
HL854_RS14765	COG3396	Phenylacetate-CoA oxygenase
HL854_RS14770	COG2030	dehydratase
HL854_RS14770	COG1012	belongs to the aldehyde dehydrogenase family
HL854_RS14790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HL854_RS14805	COG2072	flavoprotein involved in K transport
HL854_RS14810	COG0583	DNA-binding transcription factor activity
HL854_RS14815	COG1126	abc transporter atp-binding protein
HL854_RS14825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HL854_RS14840	COG1012	belongs to the aldehyde dehydrogenase family
HL854_RS14845	COG2207	Transcriptional regulator
HL854_RS14850	COG3784	Protein of unknown function (DUF1318)
HL854_RS14860	COG2911	Protein conserved in bacteria
HL854_RS14865	COG0586	Pfam SNARE associated Golgi protein
HL854_RS14870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HL854_RS14875	COG3187	Heat shock protein
HL854_RS14880	COG3042	response to heat
HL854_RS14885	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HL854_RS14885	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL854_RS14885	COG0674	pyruvate-flavodoxin oxidoreductase activity
HL854_RS14885	COG1013	pyruvate-flavodoxin oxidoreductase activity
HL854_RS14890	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HL854_RS14900	COG0589	response to stress
HL854_RS14910	COG0513	Belongs to the DEAD box helicase family
HL854_RS14920	COG1349	DNA-binding transcription factor activity
HL854_RS14925	COG0673	inositol 2-dehydrogenase activity
HL854_RS14940	COG1113	amino acid transport
HL854_RS14945	COG1522	sequence-specific DNA binding
HL854_RS14955	COG1448	Aminotransferase
HL854_RS14960	COG2011	ABC-type metal ion transport system permease component
HL854_RS14970	COG1464	Belongs to the NlpA lipoprotein family
HL854_RS14975	COG0436	Aminotransferase
HL854_RS14980	COG0604	alcohol dehydrogenase
HL854_RS15010	COG0583	DNA-binding transcription factor activity
HL854_RS15030	COG1028	Short-chain dehydrogenase reductase Sdr
HL854_RS15035	COG1309	transcriptional regulator
HL854_RS15040	COG1028	Short-chain dehydrogenase reductase Sdr
HL854_RS15095	COG1388	LysM domain
HL854_RS15100	COG2801	Transposase and inactivated derivatives
HL854_RS15110	COG2963	transposase activity
HL854_RS15115	COG2963	transposase activity
HL854_RS15125	COG3584	3D domain protein
HL854_RS15125	COG1388	LysM domain
HL854_RS15150	COG2885	chlorophyll binding
HL854_RS15175	COG0693	protein deglycase activity
HL854_RS15180	COG1028	Short-chain dehydrogenase reductase Sdr
HL854_RS15185	COG0583	DNA-binding transcription factor activity
HL854_RS15225	COG0656	L-ascorbic acid biosynthetic process
HL854_RS15265	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HL854_RS15270	COG0583	DNA-binding transcription factor activity
HL854_RS15275	COG0583	DNA-binding transcription factor activity
HL854_RS15280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HL854_RS15290	COG0765	amino acid transport
HL854_RS15300	COG4166	transmembrane transport
HL854_RS15310	COG2866	Carboxypeptidase
HL854_RS15315	COG4948	Mandelate Racemase Muconate Lactonizing
HL854_RS15320	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HL854_RS15325	COG3180	Ammonia monooxygenase
HL854_RS15340	COG3106	COG3106 Predicted ATPase
HL854_RS15350	COG1983	PspC domain protein
HL854_RS15360	COG1842	Phage shock protein A
HL854_RS15365	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HL854_RS15375	COG1473	amidohydrolase
HL854_RS15390	COG0702	epimerase
HL854_RS15405	COG4171	peptide transport system, permease
HL854_RS15420	COG2986	histidine ammonia-lyase
HL854_RS15450	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HL854_RS15455	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HL854_RS15455	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HL854_RS15470	COG1349	DNA-binding transcription factor activity
HL854_RS15480	COG0023	Translation Initiation Factor
HL854_RS15490	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HL854_RS15495	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HL854_RS15500	COG0671	phosphoesterase, PA-phosphatase related
HL854_RS15510	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HL854_RS15535	COG0616	signal peptide processing
HL854_RS15540	COG1028	Short-chain dehydrogenase reductase Sdr
HL854_RS15545	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HL854_RS15630	COG0583	DNA-binding transcription factor activity
HL854_RS15640	COG0009	L-threonylcarbamoyladenylate synthase
HL854_RS15650	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HL854_RS15655	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HL854_RS15655	COG0512	Glutamine amidotransferase of anthranilate synthase
HL854_RS15660	COG0134	indole-3-glycerol-phosphate synthase activity
HL854_RS15660	COG0135	phosphoribosylanthranilate isomerase activity
HL854_RS15705	COG4774	siderophore transport
HL854_RS15715	COG3047	cAMP biosynthetic process
HL854_RS15720	COG0727	PFAM Uncharacterised protein family (UPF0153)
HL854_RS15750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HL854_RS15755	COG1028	Short-chain dehydrogenase reductase Sdr
HL854_RS15760	COG1988	membrane-bound metal-dependent
HL854_RS15775	COG0753	catalase activity
HL854_RS15785	COG1486	melibiose metabolic process
HL854_RS15790	COG2169	Transcriptional regulator
HL854_RS15790	COG1917	Cupin 2, conserved barrel domain protein
HL854_RS15795	COG1447	Phosphotransferase system cellobiose-specific component IIA
HL854_RS15800	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HL854_RS15810	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HL854_RS15815	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HL854_RS15825	COG0322	excinuclease ABC activity
HL854_RS15830	COG3678	ATP-independent chaperone mediated protein folding
HL854_RS15840	COG3724	N-succinylarginine dihydrolase activity
HL854_RS15850	COG3138	arginine N-succinyltransferase
HL854_RS15860	COG0708	Exodeoxyribonuclease III
HL854_RS15865	COG0398	Pfam SNARE associated Golgi protein
HL854_RS15870	COG0398	Pfam SNARE associated Golgi protein
HL854_RS15875	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HL854_RS15880	COG4134	Bacterial extracellular solute-binding protein
HL854_RS15885	COG4135	transport system, permease component
HL854_RS15890	COG4136	ATPase activity
HL854_RS15895	COG2897	thiosulfate sulfurtransferase activity
HL854_RS15900	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HL854_RS15905	COG0494	nUDIX hydrolase
HL854_RS15910	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HL854_RS15915	COG1028	Short-chain dehydrogenase reductase Sdr
HL854_RS15915	COG3321	synthase
HL854_RS15915	COG0604	alcohol dehydrogenase
HL854_RS15920	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HL854_RS15925	COG0709	Synthesizes selenophosphate from selenide and ATP
HL854_RS15935	COG0778	Nitroreductase
HL854_RS15940	COG0616	signal peptide processing
HL854_RS15945	COG0252	asparaginase activity
HL854_RS15950	COG1335	isochorismatase
HL854_RS15965	COG3139	Protein of unknown function (DUF1315)
HL854_RS15985	COG0656	L-ascorbic acid biosynthetic process
HL854_RS15990	COG3713	MltA-interacting MipA family protein
HL854_RS15995	COG2766	serine protein kinase
HL854_RS16005	COG0529	Catalyzes the synthesis of activated sulfate
HL854_RS16015	COG0386	Belongs to the glutathione peroxidase family
HL854_RS16050	COG1126	abc transporter atp-binding protein
HL854_RS16055	COG0765	amino acid transport
HL854_RS16060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HL854_RS16070	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HL854_RS16085	COG0300	oxidoreductase activity
HL854_RS16090	COG0583	DNA-binding transcription factor activity
HL854_RS16095	COG1902	pentaerythritol trinitrate reductase activity
HL854_RS16105	COG1028	Short-chain dehydrogenase reductase Sdr
HL854_RS16110	COG0583	DNA-binding transcription factor activity
HL854_RS16130	COG1283	sodium-dependent phosphate transmembrane transporter activity
HL854_RS16165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HL854_RS16175	COG1126	abc transporter atp-binding protein
HL854_RS16180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HL854_RS16185	COG4948	Mandelate Racemase Muconate Lactonizing
HL854_RS16190	COG0006	proline dipeptidase activity
HL854_RS16195	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HL854_RS16205	COG0436	Aminotransferase
HL854_RS16215	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HL854_RS16235	COG0859	PFAM glycosyl transferase family 9
HL854_RS16240	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HL854_RS16250	COG2207	Transcriptional regulator
HL854_RS16255	COG2807	transmembrane transport
HL854_RS16260	COG0504	CTP synthase activity
HL854_RS16265	COG1683	Conserved Protein
HL854_RS16270	COG3189	MarR family transcriptional regulator
HL854_RS16275	COG3042	response to heat
HL854_RS16280	COG2199	diguanylate cyclase activity
HL854_RS16280	COG2203	Gaf domain
HL854_RS16300	COG3182	Iron-regulated membrane protein
HL854_RS16310	COG1560	Kdo2-lipid A biosynthetic process
HL854_RS16320	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HL854_RS16325	COG3706	GGDEF domain
HL854_RS16330	COG0583	DNA-binding transcription factor activity
HL854_RS16335	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HL854_RS16365	COG2207	Transcriptional regulator
HL854_RS16380	COG1566	PFAM secretion protein HlyD family protein
HL854_RS16385	COG1294	oxidase, subunit
HL854_RS16390	COG1271	oxidase subunit
HL854_RS16395	COG3546	catalase activity
HL854_RS16400	COG3685	Protein conserved in bacteria
HL854_RS16405	COG3685	Protein conserved in bacteria
HL854_RS16410	COG3729	General stress protein
HL854_RS16415	COG1063	alcohol dehydrogenase
HL854_RS16420	COG3813	Protein conserved in bacteria
HL854_RS16445	COG0640	Transcriptional regulator
HL854_RS16460	COG0538	isocitrate dehydrogenase activity
HL854_RS16470	COG3300	MHYT domain
HL854_RS16470	COG5001	Diguanylate cyclase
HL854_RS16475	COG3706	GGDEF domain
HL854_RS16560	COG0616	signal peptide processing
HL854_RS16575	COG4626	Terminase
HL854_RS16575	COG1802	Transcriptional regulator
HL854_RS16605	COG3772	lysozyme
HL854_RS16630	COG1403	HNH endonuclease
HL854_RS16700	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HL854_RS16710	COG0582	viral genome integration into host DNA
HL854_RS16715	COG0538	isocitrate dehydrogenase activity
HL854_RS16720	COG1187	pseudouridine synthase activity
HL854_RS16740	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HL854_RS16760	COG2205	protein histidine kinase activity
HL854_RS16765	COG2850	peptidyl-arginine hydroxylation
HL854_RS16785	COG1177	transmembrane transport
HL854_RS16800	COG0318	PFAM AMP-dependent synthetase and ligase
HL854_RS16805	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HL854_RS16810	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HL854_RS16815	COG0698	ribose 5-phosphate isomerase
HL854_RS16830	COG3395	kinase activity
HL854_RS16845	COG2390	Transcriptional regulator
HL854_RS16855	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HL854_RS16865	COG4591	ABC-type transport system involved in lipoprotein release permease component
HL854_RS16875	COG4591	ABC-type transport system involved in lipoprotein release permease component
HL854_RS16885	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HL854_RS16890	COG1376	ErfK ybiS ycfS ynhG family protein
HL854_RS16890	COG1388	LysM domain
HL854_RS16905	COG1309	transcriptional regulator
HL854_RS16920	COG3134	Outer membrane lipoprotein
HL854_RS16925	COG1252	NADH dehydrogenase
HL854_RS16950	COG5633	Lipoprotein
HL854_RS16955	COG0537	adenosine 5'-monophosphoramidase activity
HL854_RS16965	COG0084	hydrolase, TatD family'
HL854_RS16970	COG0470	DNA polymerase III
HL854_RS16980	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HL854_RS16985	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HL854_RS16990	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HL854_RS17005	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HL854_RS17025	COG1399	metal-binding, possibly nucleic acid-binding protein
HL854_RS17030	COG0424	maF-like protein
HL854_RS17045	COG1530	ribonuclease E activity
HL854_RS17050	COG0583	DNA-binding transcription factor activity
HL854_RS17055	COG2814	Major facilitator Superfamily
HL854_RS17075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HL854_RS17120	COG1560	Kdo2-lipid A biosynthetic process
HL854_RS17135	COG5645	(Lipo)protein
HL854_RS17170	COG3381	protein complex oligomerization
HL854_RS17200	COG1309	transcriptional regulator
HL854_RS17205	COG0583	DNA-binding transcription factor activity
HL854_RS17215	COG1335	isochorismatase
HL854_RS17225	COG1702	phosphate starvation-inducible protein PhoH
HL854_RS17245	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HL854_RS17255	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HL854_RS17270	COG1309	transcriptional regulator
HL854_RS17305	COG2233	PERMEase
HL854_RS17315	COG3729	General stress protein
HL854_RS17340	COG1028	Short-chain dehydrogenase reductase Sdr
HL854_RS17355	COG0531	amino acid
HL854_RS17360	COG0174	glutamine synthetase
HL854_RS17365	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HL854_RS17370	COG1917	Cupin 2, conserved barrel domain protein
HL854_RS17370	COG1396	sequence-specific DNA binding
HL854_RS17375	COG1012	belongs to the aldehyde dehydrogenase family
HL854_RS17380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HL854_RS17385	COG0583	DNA-binding transcription factor activity
HL854_RS17390	COG0473	3-isopropylmalate dehydrogenase activity
HL854_RS17395	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HL854_RS17400	COG4638	Rieske (2fe-2S)
HL854_RS17405	COG1012	belongs to the aldehyde dehydrogenase family
HL854_RS17410	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HL854_RS17415	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HL854_RS17415	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HL854_RS17415	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HL854_RS17420	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HL854_RS17425	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HL854_RS17430	COG1882	Formate acetyltransferase
HL854_RS17435	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HL854_RS17440	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HL854_RS17450	COG2207	Transcriptional regulator
HL854_RS17455	COG3706	GGDEF domain
HL854_RS17475	COG2200	EAL domain
HL854_RS17485	COG0058	SHG alpha-glucan phosphorylase activity
HL854_RS17500	COG0670	Belongs to the BI1 family
HL854_RS17515	COG2207	Transcriptional regulator
HL854_RS17520	COG1881	PFAM PEBP family protein
HL854_RS17535	COG1832	CoA-binding protein
HL854_RS17545	COG0210	DNA helicase
HL854_RS17550	COG3304	Inner membrane component domain
HL854_RS17555	COG1289	transmembrane transporter activity
HL854_RS17560	COG3070	regulator of competence-specific genes
HL854_RS17580	COG1067	ATP-dependent peptidase activity
HL854_RS17590	COG3130	regulation of translation
HL854_RS17595	COG3009	Protein conserved in bacteria
HL854_RS17600	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HL854_RS17600	COG3008	intermembrane lipid transfer
HL854_RS17605	COG2995	paraquat-inducible protein a
HL854_RS17610	COG0488	(ABC) transporter
HL854_RS17620	COG0633	Ferredoxin
HL854_RS17620	COG3217	Mosc domain protein beta barrel domain protein
HL854_RS17635	COG0431	NADPH-dependent FMN reductase
HL854_RS17640	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HL854_RS17645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HL854_RS17650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HL854_RS17660	COG0308	aminopeptidase N
HL854_RS17665	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HL854_RS17670	COG1473	amidohydrolase
HL854_RS17680	COG0814	amino acid
HL854_RS17700	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HL854_RS17705	COG1448	Aminotransferase
HL854_RS17710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HL854_RS17715	COG3108	Peptidase M15
HL854_RS17720	COG2989	Protein conserved in bacteria
HL854_RS17730	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HL854_RS17740	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HL854_RS17745	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HL854_RS17750	COG3173	Aminoglycoside phosphotransferase
HL854_RS17765	COG3214	Protein conserved in bacteria
HL854_RS17780	COG2333	competence protein COMEC
HL854_RS17780	COG0658	competence protein
HL854_RS17790	COG0539	negative regulation of cytoplasmic translation
HL854_RS17810	COG2323	membrane
HL854_RS17815	COG1944	ATP diphosphatase activity
HL854_RS17820	COG2116	formate transmembrane transporter activity
HL854_RS17825	COG1882	Formate acetyltransferase
HL854_RS17830	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HL854_RS17835	COG0477	Major facilitator Superfamily
HL854_RS17840	COG3302	dmso reductase anchor subunit
HL854_RS17845	COG0437	4 iron, 4 sulfur cluster binding
HL854_RS17850	COG0243	molybdopterin cofactor binding
HL854_RS17860	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HL854_RS17870	COG1674	ftsk spoiiie
HL854_RS17870	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HL854_RS17880	COG0492	ferredoxin-NADP+ reductase activity
HL854_RS17885	COG4988	ABC transporter
HL854_RS17890	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HL854_RS17905	COG0542	response to heat
HL854_RS17915	COG1278	Cold shock
HL854_RS17925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HL854_RS17930	COG3593	DNA synthesis involved in DNA repair
HL854_RS17940	COG2431	L-lysine efflux transmembrane transporter activity
HL854_RS17950	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HL854_RS17960	COG0028	Belongs to the TPP enzyme family
HL854_RS17965	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HL854_RS17970	COG0702	epimerase
HL854_RS17975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HL854_RS17980	COG3023	N-Acetylmuramoyl-L-alanine amidase
HL854_RS17985	COG3706	GGDEF domain
HL854_RS17985	COG2203	Gaf domain
HL854_RS17985	COG5001	Diguanylate cyclase
HL854_RS17985	COG4251	negative regulation of phosphorylation
HL854_RS18000	COG1126	abc transporter atp-binding protein
HL854_RS18005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HL854_RS18010	COG4215	(ABC) transporter
HL854_RS18015	COG4160	amino acid transport
HL854_RS18020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HL854_RS18025	COG5002	protein histidine kinase activity
HL854_RS18030	COG0745	RESPONSE REGULATOR receiver
HL854_RS18045	COG1177	transmembrane transport
HL854_RS18050	COG1176	ABC-type spermidine putrescine transport system, permease component I
HL854_RS18055	COG3842	ATPase activity
HL854_RS18060	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HL854_RS18075	COG0778	Nitroreductase
HL854_RS18100	COG3226	Transcriptional regulator
HL854_RS18105	COG0738	Major facilitator superfamily
HL854_RS18110	COG0561	phosphatase activity
HL854_RS18115	COG2814	Major facilitator Superfamily
HL854_RS18120	COG0671	phosphoesterase, PA-phosphatase related
HL854_RS18125	COG1349	DNA-binding transcription factor activity
HL854_RS18130	COG1686	Belongs to the peptidase S11 family
HL854_RS18135	COG0625	glutathione transferase activity
HL854_RS18140	COG2133	pyrroloquinoline quinone binding
HL854_RS18150	COG2223	nitrite transmembrane transporter activity
HL854_RS18175	COG0747	negative chemotaxis
HL854_RS18185	COG1446	asparaginase
HL854_RS18190	COG0303	'Molybdopterin
HL854_RS18195	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HL854_RS18200	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HL854_RS18205	COG1882	Formate acetyltransferase
HL854_RS18210	COG0561	phosphatase activity
HL854_RS18220	COG1609	Transcriptional regulator
HL854_RS18225	COG2271	Major facilitator Superfamily
HL854_RS18235	COG0488	(ABC) transporter
HL854_RS18245	COG1376	ErfK ybiS ycfS ynhG family protein
HL854_RS18250	COG2188	Transcriptional regulator
HL854_RS18255	COG2723	6-phospho-beta-galactosidase activity
HL854_RS18260	COG0667	Aldo Keto reductase
HL854_RS18265	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HL854_RS18280	COG2194	sulfuric ester hydrolase activity
HL854_RS18285	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HL854_RS18300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HL854_RS18305	COG0765	amino acid transport
HL854_RS18310	COG1126	abc transporter atp-binding protein
HL854_RS18315	COG0668	transmembrane transport
HL854_RS18325	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HL854_RS18335	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HL854_RS18345	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HL854_RS18350	COG1199	ATP-dependent helicase activity
HL854_RS18355	COG0513	Belongs to the DEAD box helicase family
HL854_RS18360	COG3958	Transketolase
HL854_RS18365	COG3959	Transketolase, thiamine diphosphate binding domain
HL854_RS18370	COG1028	Short-chain dehydrogenase reductase Sdr
HL854_RS18375	COG2271	Major facilitator Superfamily
HL854_RS18380	COG0583	DNA-binding transcription factor activity
HL854_RS18385	COG1309	transcriptional regulator
HL854_RS18390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HL854_RS18395	COG1131	(ABC) transporter
HL854_RS18400	COG0842	Transport permease protein
HL854_RS18405	COG0842	Transport permease protein
HL854_RS18415	COG3568	Endonuclease Exonuclease Phosphatase
HL854_RS18420	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HL854_RS18425	COG0392	lysyltransferase activity
HL854_RS18430	COG0670	Belongs to the BI1 family
HL854_RS18435	COG0314	molybdopterin synthase activity
HL854_RS18440	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HL854_RS18450	COG0521	Mo-molybdopterin cofactor biosynthetic process
HL854_RS18475	COG0642	Histidine kinase
HL854_RS18500	COG2226	methyltransferase
HL854_RS18515	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HL854_RS18520	COG1881	PFAM PEBP family protein
HL854_RS18560	COG4677	pectinesterase activity
HL854_RS18570	COG0589	response to stress
HL854_RS18575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HL854_RS18605	COG0789	Transcriptional regulator
HL854_RS18610	COG2200	EAL domain
HL854_RS18640	COG0561	phosphatase activity
HL854_RS18780	COG2199	diguanylate cyclase activity
HL854_RS18780	COG2200	EAL domain
HL854_RS18840	COG4149	molybdate abc transporter
HL854_RS18845	COG0725	ABC transporter, periplasmic molybdate-binding protein
HL854_RS18855	COG3585	molybdate ion transport
HL854_RS18855	COG2005	Transcriptional regulator
HL854_RS18860	COG1119	ATPase activity
HL854_RS18870	COG1085	galactose-1-phosphate uridylyltransferase
HL854_RS18880	COG2017	converts alpha-aldose to the beta-anomer
HL854_RS18890	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HL854_RS18900	COG1230	cation diffusion facilitator family transporter
HL854_RS18905	COG3201	nicotinamide mononucleotide transporter
HL854_RS18910	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HL854_RS18960	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HL854_RS18965	COG2885	chlorophyll binding
HL854_RS18975	COG3064	Membrane
HL854_RS18975	COG3064	Membrane
HL854_RS18980	COG0848	biopolymer transport protein
HL854_RS18985	COG0811	peptide transport
HL854_RS18990	COG0824	Thioesterase
HL854_RS18995	COG3790	cyd operon protein YbgE
HL854_RS19000	COG4890	Cyd operon protein YbgT
HL854_RS19005	COG1294	oxidase, subunit
HL854_RS19010	COG1271	oxidase subunit
HL854_RS19015	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HL854_RS19025	COG0508	dehydrogenase complex catalyzes the overall conversion of
HL854_RS19030	COG0567	Dehydrogenase, E1 component
HL854_RS19035	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HL854_RS19040	COG1053	succinate dehydrogenase
HL854_RS19045	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HL854_RS19050	COG2009	succinate dehydrogenase
HL854_RS19075	COG1984	allophanate hydrolase subunit 2
HL854_RS19080	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HL854_RS19125	COG2205	protein histidine kinase activity
HL854_RS19130	COG0745	RESPONSE REGULATOR receiver
HL854_RS19140	COG0033	Phosphoglucomutase
HL854_RS19150	COG0596	Alpha beta hydrolase
HL854_RS19165	COG0735	belongs to the Fur family
HL854_RS19170	COG0583	DNA-binding transcription factor activity
HL854_RS19175	COG1053	succinate dehydrogenase
HL854_RS19220	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HL854_RS19225	COG1846	Transcriptional regulator
HL854_RS19225	COG1940	carbohydrate kinase activity
HL854_RS19230	COG0647	UMP catabolic process
HL854_RS19235	COG0367	asparagine synthase
HL854_RS19275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HL854_RS19285	COG1702	phosphate starvation-inducible protein PhoH
HL854_RS19310	COG0765	amino acid transport
HL854_RS19315	COG0765	amino acid transport
HL854_RS19320	COG1126	abc transporter atp-binding protein
HL854_RS19335	COG2888	peptidyl-tyrosine sulfation
HL854_RS19350	COG1466	dna polymerase III delta subunit
HL854_RS19365	COG0799	negative regulation of ribosome biogenesis
HL854_RS19375	COG0768	penicillin binding
HL854_RS19380	COG0772	Belongs to the SEDS family
HL854_RS19385	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HL854_RS19390	COG1686	Belongs to the peptidase S11 family
HL854_RS19405	COG0583	DNA-binding transcription factor activity
HL854_RS19415	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HL854_RS19420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HL854_RS19440	COG3069	C4-dicarboxylate transmembrane transporter activity
HL854_RS19445	COG3719	Belongs to the RNase T2 family
HL854_RS19450	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HL854_RS19470	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HL854_RS19475	COG0583	DNA-binding transcription factor activity
HL854_RS19480	COG3969	phosphoadenosine phosphosulfate
HL854_RS19485	COG1475	DNA binding
HL854_RS19490	COG0436	Aminotransferase
HL854_RS19515	COG1129	ABC transporter
HL854_RS19520	COG1172	Belongs to the binding-protein-dependent transport system permease family
HL854_RS19525	COG1172	Belongs to the binding-protein-dependent transport system permease family
HL854_RS19535	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HL854_RS19550	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HL854_RS19560	COG0402	S-adenosylhomocysteine deaminase activity
HL854_RS19570	COG0483	inositol monophosphate 1-phosphatase activity
HL854_RS19575	COG2271	Major facilitator Superfamily
HL854_RS19605	COG1172	Belongs to the binding-protein-dependent transport system permease family
HL854_RS19610	COG1129	ABC transporter
HL854_RS19615	COG0371	Dehydrogenase
HL854_RS19620	COG1028	Short-chain dehydrogenase reductase Sdr
HL854_RS19635	COG2879	small protein
HL854_RS19640	COG1966	Carbon starvation protein
HL854_RS19650	COG1028	Short-chain dehydrogenase reductase Sdr
HL854_RS19655	COG1535	isochorismatase
HL854_RS19655	COG3433	isochorismatase activity
HL854_RS19660	COG1021	2,3-dihydroxybenzoate-AMP ligase
HL854_RS19665	COG1169	isochorismate synthase
HL854_RS19670	COG4592	Periplasmic binding protein
HL854_RS19680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HL854_RS19685	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HL854_RS19690	COG1120	ATPase activity
HL854_RS19695	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HL854_RS19695	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HL854_RS19700	COG3251	PFAM MbtH domain protein
HL854_RS19705	COG2382	esterase
HL854_RS19710	COG4771	TonB-dependent receptor
HL854_RS19715	COG2977	Belongs to the P-Pant transferase superfamily
HL854_RS19720	COG3958	Transketolase
HL854_RS19725	COG3959	Transketolase, thiamine diphosphate binding domain
HL854_RS19730	COG2390	Transcriptional regulator
HL854_RS19735	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HL854_RS19740	COG1879	ABC-type sugar transport system periplasmic component
HL854_RS19750	COG1129	ABC transporter
HL854_RS19755	COG1172	Belongs to the binding-protein-dependent transport system permease family
HL854_RS19765	COG1028	Short-chain dehydrogenase reductase Sdr
HL854_RS19775	COG0583	DNA-binding transcription factor activity
HL854_RS19780	COG0668	transmembrane transport
HL854_RS19790	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HL854_RS19835	COG0747	negative chemotaxis
HL854_RS19840	COG0601	transmembrane transport
HL854_RS19845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HL854_RS19850	COG0444	Belongs to the ABC transporter superfamily
HL854_RS19855	COG4608	Belongs to the ABC transporter superfamily
HL854_RS19865	COG4221	oxidoreductase activity
HL854_RS19875	COG4215	(ABC) transporter
HL854_RS19880	COG0765	amino acid transport
HL854_RS19885	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HL854_RS19900	COG0697	spore germination
HL854_RS19915	COG4608	Belongs to the ABC transporter superfamily
HL854_RS19920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HL854_RS19930	COG4166	transmembrane transport
HL854_RS19940	COG3698	Phosphodiester glycosidase
HL854_RS19980	COG2315	Protein conserved in bacteria
HL854_RS19985	COG0778	Nitroreductase
HL854_RS20010	COG0477	Major facilitator Superfamily
HL854_RS20015	COG0668	transmembrane transport
HL854_RS20030	COG0673	inositol 2-dehydrogenase activity
HL854_RS20040	COG2211	Major facilitator Superfamily
HL854_RS20045	COG1113	amino acid transport
HL854_RS20060	COG1012	belongs to the aldehyde dehydrogenase family
HL854_RS20065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HL854_RS20075	COG0531	amino acid
HL854_RS20110	COG0667	Aldo Keto reductase
HL854_RS20115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HL854_RS20120	COG1473	amidohydrolase
HL854_RS20145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HL854_RS20150	COG1120	ATPase activity
HL854_RS20155	COG1566	PFAM secretion protein HlyD family protein
HL854_RS20200	COG4211	Belongs to the binding-protein-dependent transport system permease family
HL854_RS20205	COG1129	ABC transporter
HL854_RS20220	COG0673	inositol 2-dehydrogenase activity
HL854_RS20255	COG3104	oligopeptide transport
HL854_RS20260	COG1982	Orn Lys Arg decarboxylase major
HL854_RS20265	COG0531	amino acid
HL854_RS20270	COG3710	Transcriptional regulator
HL854_RS20280	COG1560	Kdo2-lipid A biosynthetic process
HL854_RS20295	COG3188	usher protein
HL854_RS20300	COG3121	Chaperone
HL854_RS20305	COG3539	Fimbrial protein
HL854_RS20370	COG2501	S4 domain
HL854_RS20380	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HL854_RS20395	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HL854_RS20400	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HL854_RS20420	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HL854_RS20425	COG4181	ATPase activity
HL854_RS20430	COG2755	lipolytic protein G-D-S-L family
HL854_RS20435	COG0300	oxidoreductase activity
HL854_RS20440	COG3118	belongs to the thioredoxin family
HL854_RS20445	COG0390	transport system, permease component
HL854_RS20450	COG4619	ABC transporter
HL854_RS20455	COG0330	HflC and HflK could
HL854_RS20460	COG1585	Membrane protein implicated in regulation of membrane protease activity
HL854_RS20475	COG3735	TraB family
HL854_RS20480	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HL854_RS20490	COG2223	nitrite transmembrane transporter activity
HL854_RS20495	COG4651	solute:proton antiporter activity
HL854_RS20495	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HL854_RS20500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HL854_RS20540	COG2832	Protein of unknown function (DUF454)
HL854_RS20545	COG3923	Primosomal replication protein n
HL854_RS20555	COG5464	transposase or invertase
HL854_RS20560	COG3264	Mechanosensitive ion channel
HL854_RS20560	COG1196	nuclear chromosome segregation
HL854_RS20565	COG1309	transcriptional regulator
HL854_RS20570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HL854_RS20575	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HL854_RS20590	COG0110	maltose O-acetyltransferase activity
HL854_RS20640	COG1874	Beta-galactosidase
HL854_RS20645	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HL854_RS20650	COG3833	ABC-type maltose transport systems, permease component
HL854_RS20655	COG1175	transmembrane transport
HL854_RS20660	COG2182	Extracellular solute-binding protein
HL854_RS20670	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HL854_RS20685	COG2364	Membrane
HL854_RS20715	COG3695	enzyme binding
HL854_RS20720	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HL854_RS20725	COG1946	Acyl-CoA thioesterase
HL854_RS20730	COG0004	ammonium transporteR
HL854_RS20735	COG0347	Belongs to the P(II) protein family
HL854_RS20740	COG1132	(ABC) transporter
HL854_RS20745	COG1132	(ABC) transporter
HL854_RS20750	COG1522	sequence-specific DNA binding
HL854_RS20765	COG4533	DNA binding
HL854_RS20775	COG0824	Thioesterase
HL854_RS20780	COG1555	photosystem II stabilization
HL854_RS20785	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HL854_RS20790	COG0776	regulation of translation
HL854_RS20795	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HL854_RS20815	COG0271	Belongs to the BolA IbaG family
HL854_RS20820	COG3056	Lipoprotein
HL854_RS20825	COG2223	nitrite transmembrane transporter activity
HL854_RS20830	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HL854_RS20835	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HL854_RS20840	COG1845	cytochrome c oxidase, subunit III
HL854_RS20845	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HL854_RS20860	COG1414	Transcriptional regulator
HL854_RS20865	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HL854_RS20870	COG1053	succinate dehydrogenase
HL854_RS20880	COG1053	succinate dehydrogenase
HL854_RS20895	COG0673	inositol 2-dehydrogenase activity
HL854_RS20900	COG2814	Major facilitator Superfamily
HL854_RS20910	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HL854_RS20935	COG0142	geranyltranstransferase activity
HL854_RS20945	COG0667	Aldo Keto reductase
HL854_RS20950	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HL854_RS20955	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HL854_RS20970	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HL854_RS20970	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HL854_RS20980	COG4238	major outer membrane lipoprotein
HL854_RS21000	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HL854_RS21005	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HL854_RS21010	COG1862	Preprotein translocase
HL854_RS21035	COG0450	alkyl hydroperoxide reductase
HL854_RS21045	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HL854_RS21060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HL854_RS21070	COG1228	amidohydrolase
HL854_RS21080	COG1335	isochorismatase
HL854_RS21085	COG0583	DNA-binding transcription factor activity
HL854_RS21090	COG0366	Alpha amylase catalytic
HL854_RS21120	COG0420	3'-5' exonuclease activity
HL854_RS21125	COG0419	ATPase involved in DNA repair
HL854_RS21130	COG1940	carbohydrate kinase activity
HL854_RS21145	COG4126	flavin adenine dinucleotide binding
HL854_RS21155	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HL854_RS21160	COG3416	Protein conserved in bacteria
HL854_RS21170	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HL854_RS21180	COG1785	Belongs to the alkaline phosphatase family
HL854_RS21220	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HL854_RS21225	COG1335	isochorismatase
HL854_RS21230	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HL854_RS21235	COG0113	porphobilinogen synthase activity
HL854_RS21240	COG1943	Transposase
HL854_RS21250	COG2175	clavaminate synthase activity
HL854_RS21255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HL854_RS21260	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HL854_RS21265	COG4521	taurine ABC transporter
HL854_RS21270	COG2040	homocysteine
HL854_RS21275	COG0833	amino acid
HL854_RS21290	COG4303	Ethanolamine ammonia lyase large subunit
HL854_RS21295	COG4302	ethanolamine ammonia-lyase activity
HL854_RS21335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HL854_RS21340	COG1126	abc transporter atp-binding protein
HL854_RS21345	COG4597	amino acid ABC transporter
HL854_RS21350	COG0765	amino acid transport
HL854_RS21365	COG3188	usher protein
HL854_RS21390	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HL854_RS21400	COG3639	organic phosphonate transmembrane transporter activity
HL854_RS21415	COG0791	NLP P60 protein
HL854_RS21500	COG0582	viral genome integration into host DNA
HL854_RS21530	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HL854_RS21535	COG0022	dehydrogenase e1 component
HL854_RS21540	COG0508	dehydrogenase complex catalyzes the overall conversion of
HL854_RS21545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HL854_RS21555	COG0625	glutathione transferase activity
HL854_RS21560	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HL854_RS21575	COG0579	oxidoreductase
HL854_RS21580	COG1012	belongs to the aldehyde dehydrogenase family
HL854_RS21585	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HL854_RS21590	COG1113	amino acid transport
HL854_RS21595	COG1802	Transcriptional regulator
HL854_RS21600	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HL854_RS21610	COG1596	polysaccharide export
HL854_RS21630	COG0463	Glycosyl transferase, family 2
HL854_RS21635	COG0438	transferase activity, transferring glycosyl groups
HL854_RS21640	COG0297	glycogen (starch) synthase activity
HL854_RS21640	COG0438	transferase activity, transferring glycosyl groups
HL854_RS21655	COG1045	serine acetyltransferase
HL854_RS21675	COG2195	Cleaves the N-terminal amino acid of tripeptides
HL854_RS21680	COG0454	-acetyltransferase
HL854_RS21695	COG2991	Protein conserved in bacteria
HL854_RS21710	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HL854_RS21715	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HL854_RS21730	COG3034	peptidoglycan biosynthetic process
HL854_RS21735	COG0121	glutamine amidotransferase
HL854_RS21745	COG1960	acyl-CoA dehydrogenase activity
HL854_RS21750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HL854_RS21765	COG0583	DNA-binding transcription factor activity
HL854_RS21785	COG2226	methyltransferase
HL854_RS21795	COG1388	LysM domain
HL854_RS21795	COG0741	lytic transglycosylase activity
HL854_RS21800	COG2226	methyltransferase
HL854_RS21810	COG2814	Major facilitator Superfamily
HL854_RS21815	COG0583	DNA-binding transcription factor activity
HL854_RS21820	COG0656	L-ascorbic acid biosynthetic process
HL854_RS21855	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HL854_RS21865	COG2011	ABC-type metal ion transport system permease component
HL854_RS21870	COG1464	Belongs to the NlpA lipoprotein family
HL854_RS21880	COG1720	tRNA m6t6A37 methyltransferase activity
HL854_RS21890	COG0791	NLP P60 protein
HL854_RS21895	COG3015	lipoprotein NlpE involved in copper resistance
HL854_RS21900	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HL854_RS21915	COG4568	rho-dependent transcription termination
HL854_RS21925	COG0346	lactoylglutathione lyase activity
HL854_RS21970	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HL854_RS21980	COG0750	zinc metalloprotease
HL854_RS21985	COG0575	Belongs to the CDS family
HL854_RS22020	COG0024	Methionine aminopeptidase
HL854_RS22025	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HL854_RS22040	COG3835	regulator
HL854_RS22045	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HL854_RS22065	COG2860	membrane
HL854_RS22085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HL854_RS22090	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HL854_RS22095	COG1120	ATPase activity
HL854_RS22100	COG4774	siderophore transport
HL854_RS22105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HL854_RS22195	COG1643	Atp-dependent helicase
HL854_RS22200	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HL854_RS22220	COG0617	tRNA 3'-terminal CCA addition
HL854_RS22225	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HL854_RS22245	COG0726	polysaccharide deacetylase
HL854_RS22250	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HL854_RS22255	COG0842	Transport permease protein
HL854_RS22260	COG1131	(ABC) transporter
HL854_RS22265	COG0288	reversible hydration of carbon dioxide
HL854_RS22280	COG4993	Dehydrogenase
HL854_RS22285	COG2132	Multicopper oxidase
HL854_RS22300	COG0545	Peptidyl-prolyl cis-trans isomerase
HL854_RS22325	COG3064	Membrane
HL854_RS22340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HL854_RS22345	COG0508	dehydrogenase complex catalyzes the overall conversion of
HL854_RS22350	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HL854_RS22355	COG2186	Transcriptional regulator
HL854_RS22360	COG1113	amino acid transport
HL854_RS22365	COG2211	Major facilitator Superfamily
HL854_RS22370	COG3940	Belongs to the glycosyl hydrolase 43 family
HL854_RS22375	COG3725	Membrane protein required for beta-lactamase induction
HL854_RS22380	COG3023	N-Acetylmuramoyl-L-alanine amidase
HL854_RS22390	COG4969	Belongs to the N-Me-Phe pilin family
HL854_RS22395	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HL854_RS22400	COG1459	type II secretion system
HL854_RS22425	COG0494	nUDIX hydrolase
HL854_RS22445	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HL854_RS22450	COG0849	cell division
HL854_RS22460	COG1181	Belongs to the D-alanine--D-alanine ligase family
HL854_RS22475	COG0772	Belongs to the SEDS family
HL854_RS22490	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HL854_RS22500	COG0768	penicillin binding
HL854_RS22520	COG1609	Transcriptional regulator
HL854_RS22530	COG0028	Belongs to the TPP enzyme family
HL854_RS22570	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HL854_RS22575	COG0738	Major facilitator superfamily
HL854_RS22585	COG0583	DNA-binding transcription factor activity
HL854_RS22590	COG2271	Major facilitator Superfamily
HL854_RS22595	COG2814	Major facilitator Superfamily
HL854_RS22615	COG1178	ABC-type Fe3 transport system permease component
HL854_RS22625	COG0586	Pfam SNARE associated Golgi protein
HL854_RS22645	COG0235	Class ii aldolase
HL854_RS22650	COG0417	DNA replication proofreading
HL854_RS22660	COG0564	pseudouridine synthase activity
HL854_RS22670	COG3493	citrate carrier protein
HL854_RS22685	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HL854_RS22690	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HL854_RS22700	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HL854_RS22735	COG2271	Major facilitator Superfamily
HL854_RS22740	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HL854_RS22745	COG1609	Transcriptional regulator
HL854_RS22750	COG1028	Short-chain dehydrogenase reductase Sdr
HL854_RS22755	COG3265	gluconokinase activity
HL854_RS22760	COG2731	YhcH YjgK YiaL family protein
HL854_RS22775	COG0505	Belongs to the CarA family
HL854_RS22820	COG5016	pyruvate
HL854_RS22820	COG0511	ligase activity, forming carbon-carbon bonds
HL854_RS22865	COG1047	Peptidyl-prolyl cis-trans
HL854_RS22880	COG0196	riboflavin kinase activity
HL854_RS22895	COG0583	DNA-binding transcription factor activity
HL854_RS22920	COG4735	regulation of single-species biofilm formation
HL854_RS22925	COG1584	GPR1 FUN34 yaaH family protein
HL854_RS22930	COG0477	Major facilitator Superfamily
HL854_RS22935	COG0521	Mo-molybdopterin cofactor biosynthetic process
HL854_RS22940	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HL854_RS22945	COG1115	amino acid carrier protein
HL854_RS22960	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HL854_RS22970	COG0460	homoserine dehydrogenase
HL854_RS22970	COG0527	aspartate kinase activity
HL854_RS22980	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HL854_RS22990	COG0745	RESPONSE REGULATOR receiver
HL854_RS22995	COG4452	Inner membrane protein CreD
HL854_RS23000	COG2205	protein histidine kinase activity
HL854_RS23005	COG0745	RESPONSE REGULATOR receiver
HL854_RS23010	COG3045	CreA protein
HL854_RS23015	COG3708	Transcriptional regulator
HL854_RS23015	COG2207	Transcriptional regulator
HL854_RS23035	COG0741	lytic transglycosylase activity
HL854_RS23040	COG0488	(ABC) transporter
HL854_RS23050	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HL854_RS23055	COG0560	Phosphoserine phosphatase
HL854_RS23060	COG3726	membrane protein affecting hemolysin expression
HL854_RS23090	COG0084	hydrolase, TatD family'
HL854_RS23095	COG4667	esterase of the alpha-beta hydrolase superfamily
HL854_RS23105	COG2823	Periplasmic or secreted lipoprotein
HL854_RS23115	COG1011	Hydrolase
HL854_RS23120	COG0456	acetyltransferase
HL854_RS23125	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HL854_RS23160	COG3706	GGDEF domain
HL854_RS23165	COG4114	ferric iron reductase
HL854_RS23170	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HL854_RS23175	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HL854_RS23180	COG2197	response regulator
HL854_RS23185	COG2197	response regulator
HL854_RS23190	COG2169	Transcriptional regulator
HL854_RS23190	COG1917	Cupin 2, conserved barrel domain protein
HL854_RS23200	COG2966	Psort location CytoplasmicMembrane, score
HL854_RS23215	COG1484	DNA-dependent DNA replication
HL854_RS23240	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HL854_RS23245	COG3716	PTS system mannose fructose sorbose family IID component
HL854_RS23250	COG3715	PTS system
HL854_RS23265	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HL854_RS23265	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HL854_RS23275	COG1063	alcohol dehydrogenase
HL854_RS23280	COG1802	Transcriptional regulator
HL854_RS23285	COG2271	Major facilitator Superfamily
HL854_RS23290	COG1214	PFAM Peptidase M22, glycoprotease
HL854_RS23290	COG0456	acetyltransferase
HL854_RS23305	COG0531	amino acid
HL854_RS23310	COG1012	belongs to the aldehyde dehydrogenase family
HL854_RS23315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HL854_RS23345	COG1846	Transcriptional regulator
HL854_RS23355	COG0179	Fumarylacetoacetate (FAA) hydrolase
HL854_RS23365	COG1012	belongs to the aldehyde dehydrogenase family
HL854_RS23370	COG3384	dioxygenase
HL854_RS23380	COG3971	2-oxopent-4-enoate hydratase activity
HL854_RS23400	COG2368	4-hydroxyphenylacetate
HL854_RS23405	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HL854_RS23425	COG3210	domain, Protein
HL854_RS23430	COG2831	hemolysin activation secretion protein
HL854_RS23435	COG1966	Carbon starvation protein
HL854_RS23440	COG2879	small protein
HL854_RS23445	COG0523	cobalamin synthesis protein
HL854_RS23460	COG1012	belongs to the aldehyde dehydrogenase family
HL854_RS23465	COG5464	transposase or invertase
HL854_RS23470	COG2207	Transcriptional regulator
HL854_RS23470	COG1917	Cupin 2, conserved barrel domain protein
HL854_RS23480	COG2733	membrane
HL854_RS23495	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HL854_RS23500	COG1924	4 iron, 4 sulfur cluster binding
HL854_RS23510	COG1473	amidohydrolase
HL854_RS23515	COG0700	Nucleoside recognition
HL854_RS23520	COG3366	ferrous iron transmembrane transporter activity
HL854_RS23535	COG1566	PFAM secretion protein HlyD family protein
HL854_RS23545	COG5457	Domain of unknown function (DUF1127)
HL854_RS23550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HL854_RS23560	COG0583	DNA-binding transcription factor activity
HL854_RS23565	COG2249	NAD(P)H dehydrogenase (quinone) activity
HL854_RS23600	COG1012	belongs to the aldehyde dehydrogenase family
HL854_RS23600	COG1454	alcohol dehydrogenase
HL854_RS23615	COG1882	Formate acetyltransferase
HL854_RS23620	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HL854_RS23630	COG4869	propanediol catabolic process
HL854_RS23655	COG3706	GGDEF domain
HL854_RS23660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HL854_RS23665	COG0842	Transport permease protein
HL854_RS23665	COG1129	ABC transporter
HL854_RS23670	COG0842	Transport permease protein
HL854_RS23705	COG2850	peptidyl-arginine hydroxylation
HL854_RS23710	COG5002	protein histidine kinase activity
HL854_RS23715	COG0745	RESPONSE REGULATOR receiver
HL854_RS23720	COG1538	Outer membrane efflux protein
HL854_RS23725	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HL854_RS23730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HL854_RS23735	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HL854_RS23745	COG3040	lipid binding
HL854_RS23750	COG0789	Transcriptional regulator
HL854_RS23755	COG3631	Ketosteroid isomerase-related protein
HL854_RS23760	COG0300	oxidoreductase activity
HL854_RS23775	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HL854_RS23795	COG3272	Protein of unknown function (DUF1722)
HL854_RS23800	COG4580	involved in the transport of maltose and maltodextrins
HL854_RS23805	COG2115	Belongs to the xylose isomerase family
HL854_RS23810	COG2211	Major facilitator Superfamily
HL854_RS23815	COG3507	Belongs to the glycosyl hydrolase 43 family
HL854_RS23850	COG1061	Type III restriction enzyme res subunit
HL854_RS23865	COG0288	reversible hydration of carbon dioxide
HL854_RS23870	COG0659	secondary active sulfate transmembrane transporter activity
HL854_RS23875	COG1064	alcohol dehydrogenase
HL854_RS23880	COG1175	transmembrane transport
HL854_RS23885	COG0395	ABC-type sugar transport system, permease component
HL854_RS23890	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HL854_RS23895	COG3842	ATPase activity
HL854_RS23900	COG1653	transport
HL854_RS23910	COG1082	Xylose isomerase domain protein TIM barrel
HL854_RS23920	COG3962	Belongs to the TPP enzyme family
HL854_RS23925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HL854_RS23930	COG1737	Transcriptional regulator
HL854_RS23930	COG0837	glucose binding
HL854_RS23935	COG3718	enzyme involved in inositol metabolism
HL854_RS23950	COG0433	COG0433 Predicted ATPase
HL854_RS23955	COG0795	lipopolysaccharide-transporting ATPase activity
HL854_RS23960	COG0795	lipopolysaccharide-transporting ATPase activity
HL854_RS23970	COG2927	DNA polymerase III (CHI subunit)
HL854_RS23975	COG0525	valine-tRNA ligase activity
HL854_RS24000	COG2731	YhcH YjgK YiaL family protein
HL854_RS24035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HL854_RS24035	COG1263	PTS System
HL854_RS24040	COG0366	Alpha amylase catalytic
HL854_RS24050	COG0602	queuosine metabolic process
HL854_RS24055	COG3711	transcriptional antiterminator
HL854_RS24055	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HL854_RS24060	COG2706	6-phosphogluconolactonase activity
HL854_RS24075	COG3964	amidohydrolase
HL854_RS24115	COG0312	modulator of DNA gyrase
HL854_RS24140	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HL854_RS24150	COG1172	Belongs to the binding-protein-dependent transport system permease family
HL854_RS24155	COG1172	Belongs to the binding-protein-dependent transport system permease family
HL854_RS24160	COG1129	ABC transporter
HL854_RS24165	COG1879	ABC-type sugar transport system periplasmic component
HL854_RS24180	COG2105	PFAM AIG2 family protein
HL854_RS24185	COG2911	Protein conserved in bacteria
HL854_RS24190	COG0729	surface antigen
HL854_RS24205	COG1914	H( )-stimulated, divalent metal cation uptake system
HL854_RS24210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HL854_RS24215	COG1609	Transcriptional regulator
HL854_RS24220	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HL854_RS24225	COG1253	flavin adenine dinucleotide binding
HL854_RS24240	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HL854_RS24255	COG1733	regulation of RNA biosynthetic process
HL854_RS24260	COG0702	epimerase
HL854_RS24270	COG0697	spore germination
HL854_RS24280	COG1113	amino acid transport
HL854_RS24285	COG0545	Peptidyl-prolyl cis-trans isomerase
HL854_RS24290	COG3061	Opacity-associated protein A
HL854_RS24300	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HL854_RS24305	COG2965	DNA replication, synthesis of RNA primer
HL854_RS24365	COG1073	alpha beta
HL854_RS24370	COG3650	response to hydrogen peroxide
HL854_RS24380	COG1960	acyl-CoA dehydrogenase activity
HL854_RS24385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HL854_RS24390	COG0557	exoribonuclease II activity
HL854_RS24405	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HL854_RS24415	COG0330	HflC and HflK could
HL854_RS24420	COG0330	HflC and HflK could
HL854_RS24425	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HL854_RS24450	COG0802	atpase or kinase
HL854_RS24455	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HL854_RS24455	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HL854_RS24460	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HL854_RS24480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HL854_RS24500	COG3264	Mechanosensitive ion channel
HL854_RS24500	COG1511	domain protein
HL854_RS24515	COG1053	succinate dehydrogenase
HL854_RS24520	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HL854_RS24540	COG2076	Multidrug Resistance protein
HL854_RS24560	COG1509	lysine 2,3-aminomutase activity
HL854_RS24625	COG0531	amino acid
HL854_RS24630	COG3030	protein affecting phage T7 exclusion by the F plasmid
HL854_RS24635	COG1027	Aspartate ammonia-lyase
HL854_RS24640	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HL854_RS24655	COG1309	transcriptional regulator
HL854_RS24680	COG0457	Tetratricopeptide repeat
HL854_RS24685	COG1649	PFAM Uncharacterised BCR, COG1649
HL854_RS24685	COG0726	polysaccharide deacetylase
HL854_RS24690	COG1215	transferase activity, transferring glycosyl groups
HL854_RS24705	COG0861	Integral membrane protein TerC family
HL854_RS24740	COG1486	melibiose metabolic process
HL854_RS24745	COG2169	Transcriptional regulator
HL854_RS24755	COG2824	Alkylphosphonate utilization operon protein PhnA
HL854_RS24760	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HL854_RS24765	COG2188	Transcriptional regulator
HL854_RS24770	COG3624	Phosphonate C-P lyase system protein PhnG
HL854_RS24775	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HL854_RS24780	COG3626	phosphonate metabolism
HL854_RS24785	COG3627	carbon phosphorus lyase activity
HL854_RS24790	COG4107	phosphonate C-P lyase system protein PhnK
HL854_RS24795	COG4778	phosphonate C-P lyase system protein PhnL
HL854_RS24800	COG3454	Phosphonate metabolism
HL854_RS24810	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HL854_RS24820	COG0784	Response regulator, receiver
HL854_RS24820	COG4191	Histidine kinase
HL854_RS24825	COG1129	ABC transporter
HL854_RS24830	COG1172	Belongs to the binding-protein-dependent transport system permease family
HL854_RS24865	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HL854_RS24870	COG1301	dicarboxylic acid transport
HL854_RS24885	COG3162	membrane
HL854_RS24915	COG3539	Fimbrial protein
HL854_RS24920	COG1346	cytolysis
HL854_RS24925	COG1380	Effector of murein hydrolase LrgA
HL854_RS24930	COG0583	DNA-binding transcription factor activity
HL854_RS24935	COG0025	NhaP-type Na H and K H
HL854_RS24940	COG2252	PERMEase
HL854_RS24945	COG0625	glutathione transferase activity
HL854_RS24950	COG0789	Transcriptional regulator
HL854_RS24960	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HL854_RS24985	COG3842	ATPase activity
HL854_RS24990	COG1234	tRNA 3'-trailer cleavage
HL854_RS24995	COG1609	Transcriptional regulator
HL854_RS25000	COG0483	inositol monophosphate 1-phosphatase activity
HL854_RS25010	COG0583	DNA-binding transcription factor activity
HL854_RS25020	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HL854_RS25035	COG4771	TonB-dependent receptor
HL854_RS25040	COG0741	lytic transglycosylase activity
HL854_RS25045	COG0629	single-stranded DNA binding
HL854_RS25055	COG2315	Protein conserved in bacteria
HL854_RS25060	COG0432	Pfam Uncharacterised protein family UPF0047
HL854_RS25075	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HL854_RS25080	COG0305	Participates in initiation and elongation during chromosome replication
HL854_RS25095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HL854_RS25105	COG0735	belongs to the Fur family
HL854_RS25110	COG3237	CsbD-like
HL854_RS25115	COG0534	Mate efflux family protein
HL854_RS25125	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HL854_RS25185	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HL854_RS25195	COG0527	aspartate kinase activity
HL854_RS25260	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HL854_RS25290	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HL854_RS25300	COG0456	acetyltransferase
HL854_RS25330	COG0151	Belongs to the GarS family
HL854_RS25340	COG4191	Histidine kinase
HL854_RS25380	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HL854_RS25395	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HL854_RS25400	COG2104	thiamine diphosphate biosynthetic process
HL854_RS25410	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HL854_RS25415	COG3706	GGDEF domain
HL854_RS25425	COG1447	Phosphotransferase system cellobiose-specific component IIA
HL854_RS25430	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HL854_RS25465	COG0250	Participates in transcription elongation, termination and antitermination
HL854_RS25510	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HL854_RS25540	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HL854_RS25550	COG1739	Uncharacterized protein family UPF0029
HL854_RS25590	COG0805	protein transport
HL854_RS25610	COG3165	ubiquinone biosynthetic process from chorismate
HL854_RS25630	COG0412	Dienelactone hydrolase
HL854_RS25640	COG0583	DNA-binding transcription factor activity
HL854_RS25645	COG0697	spore germination
HL854_RS25650	COG0561	phosphatase activity
HL854_RS25655	COG2267	carboxylic ester hydrolase activity
HL854_RS25660	COG1280	lysine exporter protein (LysE YggA)
HL854_RS25670	COG1280	lysine exporter protein (LysE YggA)
HL854_RS25700	COG0210	DNA helicase
HL854_RS25705	COG1011	Hydrolase
HL854_RS25735	COG3072	Adenylate cyclase
HL854_RS25750	COG2959	enzyme of heme biosynthesis
HL854_RS25755	COG3071	HemY protein
HL854_RS25800	COG2244	polysaccharide biosynthetic process
HL854_RS25805	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HL854_RS25810	COG0456	acetyltransferase
HL854_RS25815	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HL854_RS25820	COG1088	dTDP-glucose 4,6-dehydratase activity
HL854_RS25825	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HL854_RS25830	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HL854_RS25840	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HL854_RS25845	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HL854_RS25850	COG3118	belongs to the thioredoxin family
HL854_RS25875	COG1811	Na channel or pump
HL854_RS25885	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HL854_RS25890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HL854_RS25900	COG0583	DNA-binding transcription factor activity
HL854_RS25905	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HL854_RS25915	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HL854_RS25920	COG3978	acetolactate synthase activity
HL854_RS25940	COG3085	chromosome segregation
HL854_RS26015	COG0583	DNA-binding transcription factor activity
HL854_RS26030	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HL854_RS26045	COG3443	Belongs to the bacterial solute-binding protein 9 family
HL854_RS26050	COG2207	Transcriptional regulator
HL854_RS26060	COG0371	Dehydrogenase
HL854_RS26070	COG0583	DNA-binding transcription factor activity
HL854_RS26080	COG0460	homoserine dehydrogenase
HL854_RS26080	COG0527	aspartate kinase activity
HL854_RS26085	COG0626	cystathionine gamma-synthase activity
HL854_RS26100	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HL854_RS26105	COG1609	Transcriptional regulator
HL854_RS26110	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HL854_RS26125	COG1575	Belongs to the MenA family. Type 1 subfamily
HL854_RS26145	COG3678	ATP-independent chaperone mediated protein folding
HL854_RS26150	COG0745	RESPONSE REGULATOR receiver
HL854_RS26155	COG2205	protein histidine kinase activity
HL854_RS26160	COG2258	MOSC domain
HL854_RS26165	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HL854_RS26205	COG1129	ABC transporter
HL854_RS26210	COG1172	Belongs to the binding-protein-dependent transport system permease family
HL854_RS26215	COG1172	Belongs to the binding-protein-dependent transport system permease family
HL854_RS26220	COG1454	alcohol dehydrogenase
HL854_RS26230	COG2211	Major facilitator Superfamily
HL854_RS26290	COG0205	6-phosphofructokinase activity
HL854_RS26310	COG0437	4 iron, 4 sulfur cluster binding
HL854_RS26315	COG2864	formate dehydrogenase
HL854_RS26330	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HL854_RS26340	COG0456	acetyltransferase
HL854_RS26355	COG1011	Hydrolase
HL854_RS26370	COG3852	Histidine kinase
HL854_RS26385	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HL854_RS26405	COG0204	Acyl-transferase
HL854_RS26415	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HL854_RS26420	COG3084	Protein conserved in bacteria
HL854_RS26430	COG1763	Mo-molybdopterin cofactor biosynthetic process
HL854_RS26455	COG2186	Transcriptional regulator
HL854_RS26460	COG0477	Major facilitator Superfamily
HL854_RS26465	COG1609	Transcriptional regulator
HL854_RS26470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HL854_RS26480	COG1172	Belongs to the binding-protein-dependent transport system permease family
HL854_RS26485	COG1129	ABC transporter
HL854_RS26515	COG1522	sequence-specific DNA binding
HL854_RS26520	COG0716	FMN binding
HL854_RS26535	COG3312	ion transport
HL854_RS26585	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HL854_RS26590	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HL854_RS26595	COG0573	inorganic phosphate transmembrane transporter activity
HL854_RS26600	COG0581	inorganic phosphate transmembrane transporter activity
HL854_RS26605	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HL854_RS26610	COG0704	Plays a role in the regulation of phosphate uptake
HL854_RS26620	COG2382	esterase
HL854_RS26625	COG0363	glucosamine-6-phosphate deaminase activity
HL854_RS26630	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HL854_RS26635	COG2252	PERMEase
HL854_RS26640	COG0431	NADPH-dependent FMN reductase
HL854_RS26645	COG2091	lysine biosynthetic process via aminoadipic acid
HL854_RS26705	COG0582	viral genome integration into host DNA
HL854_RS26720	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HL854_RS26750	COG1716	ATPase activity
HL854_RS26750	COG5001	Diguanylate cyclase
HL854_RS26780	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HL854_RS26805	COG5290	Psort location Cytoplasmic, score
HL854_RS26840	COG2801	Transposase and inactivated derivatives
HL854_RS27175	COG0431	NADPH-dependent FMN reductase
HL854_RS27205	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HL854_RS27295	COG1227	inorganic diphosphatase activity
HL854_RS27305	COG0148	phosphopyruvate hydratase activity
HL854_RS27310	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity