locus-tag	class	description
ISA69_RS00005	COG1125	glycine betaine transport
ISA69_RS00020	COG3275	phosphorelay sensor kinase activity
ISA69_RS00030	COG4807	Protein conserved in bacteria
ISA69_RS00050	COG5455	response to cobalt ion
ISA69_RS00055	COG0583	DNA-binding transcription factor activity
ISA69_RS00060	COG2252	PERMEase
ISA69_RS00070	COG0583	DNA-binding transcription factor activity
ISA69_RS00085	COG0351	phosphomethylpyrimidine kinase
ISA69_RS00090	COG1830	Aldolase
ISA69_RS00105	COG1070	Carbohydrate kinase
ISA69_RS00115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISA69_RS00120	COG4948	Mandelate Racemase Muconate Lactonizing
ISA69_RS00125	COG0747	negative chemotaxis
ISA69_RS00130	COG0601	transmembrane transport
ISA69_RS00135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISA69_RS00140	COG0444	Belongs to the ABC transporter superfamily
ISA69_RS00145	COG4608	Belongs to the ABC transporter superfamily
ISA69_RS00155	COG0826	peptidase U32
ISA69_RS00160	COG0745	RESPONSE REGULATOR receiver
ISA69_RS00165	COG2205	protein histidine kinase activity
ISA69_RS00190	COG1301	dicarboxylic acid transport
ISA69_RS00210	COG5002	protein histidine kinase activity
ISA69_RS00215	COG0443	Heat shock 70 kDa protein
ISA69_RS00220	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ISA69_RS00235	COG2982	Protein involved in outer membrane biogenesis
ISA69_RS00240	COG1253	flavin adenine dinucleotide binding
ISA69_RS00285	COG1088	dTDP-glucose 4,6-dehydratase activity
ISA69_RS00340	COG2244	polysaccharide biosynthetic process
ISA69_RS00390	COG0438	transferase activity, transferring glycosyl groups
ISA69_RS00415	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ISA69_RS00445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISA69_RS00450	COG0583	DNA-binding transcription factor activity
ISA69_RS00460	COG0531	amino acid
ISA69_RS00475	COG3604	Transcriptional regulator
ISA69_RS00480	COG2205	protein histidine kinase activity
ISA69_RS00565	COG0640	Transcriptional regulator
ISA69_RS00570	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ISA69_RS00575	COG2925	Exonuclease
ISA69_RS00590	COG1289	transmembrane transporter activity
ISA69_RS00610	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ISA69_RS00620	COG1942	4-Oxalocrotonate Tautomerase
ISA69_RS00625	COG0583	DNA-binding transcription factor activity
ISA69_RS00630	COG0095	Lipoate-protein ligase
ISA69_RS00635	COG0477	Major facilitator Superfamily
ISA69_RS00645	COG5001	Diguanylate cyclase
ISA69_RS00645	COG3300	MHYT domain
ISA69_RS00655	COG3615	Tellurite resistance protein tehB
ISA69_RS00680	COG3706	GGDEF domain
ISA69_RS00705	COG0534	Mate efflux family protein
ISA69_RS00715	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ISA69_RS00735	COG0604	alcohol dehydrogenase
ISA69_RS00740	COG1309	transcriptional regulator
ISA69_RS00745	COG0025	NhaP-type Na H and K H
ISA69_RS00750	COG1045	serine acetyltransferase
ISA69_RS00755	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ISA69_RS00775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISA69_RS00780	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ISA69_RS00830	COG1028	Short-chain dehydrogenase reductase Sdr
ISA69_RS00840	COG0523	cobalamin synthesis protein
ISA69_RS00865	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ISA69_RS00875	COG1418	mRNA catabolic process
ISA69_RS00880	COG0270	DNA (cytosine-5-)-methyltransferase activity
ISA69_RS00885	COG3727	T/G mismatch-specific endonuclease activity
ISA69_RS00890	COG0697	spore germination
ISA69_RS00895	COG2354	Protein conserved in bacteria
ISA69_RS00925	COG0366	Alpha amylase catalytic
ISA69_RS00930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA69_RS00940	COG0765	amino acid transport
ISA69_RS00945	COG1126	abc transporter atp-binding protein
ISA69_RS00950	COG2197	response regulator
ISA69_RS00960	COG2197	response regulator
ISA69_RS01000	COG3012	SEC-C Motif Domain Protein
ISA69_RS01000	COG3318	Belongs to the UPF0149 family
ISA69_RS01005	COG0814	amino acid
ISA69_RS01015	COG1528	Iron-storage protein
ISA69_RS01030	COG0477	Major facilitator Superfamily
ISA69_RS01040	COG2211	Major facilitator Superfamily
ISA69_RS01045	COG1528	Iron-storage protein
ISA69_RS01050	COG1879	ABC-type sugar transport system periplasmic component
ISA69_RS01060	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA69_RS01085	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ISA69_RS01095	COG3102	Protein conserved in bacteria
ISA69_RS01115	COG3788	relative of glutathione S-transferase, MAPEG superfamily
ISA69_RS01120	COG1801	Protein of unknown function DUF72
ISA69_RS01125	COG1335	isochorismatase
ISA69_RS01135	COG0494	nUDIX hydrolase
ISA69_RS01160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISA69_RS01170	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ISA69_RS01175	COG0739	heme binding
ISA69_RS01180	COG1560	Kdo2-lipid A biosynthetic process
ISA69_RS01200	COG3493	citrate carrier protein
ISA69_RS01210	COG1737	Transcriptional regulator
ISA69_RS01220	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISA69_RS01225	COG0129	dihydroxy-acid dehydratase activity
ISA69_RS01230	COG0800	Aldolase
ISA69_RS01240	COG3141	response to X-ray
ISA69_RS01245	COG2979	Protein of unknown function (DUF533)
ISA69_RS01250	COG1770	oligopeptidase
ISA69_RS01255	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISA69_RS01265	COG2372	response to copper ion
ISA69_RS01270	COG1276	copper resistance
ISA69_RS01285	COG2990	Protein conserved in bacteria
ISA69_RS01310	COG3008	intermembrane lipid transfer
ISA69_RS01315	COG2995	paraquat-inducible protein a
ISA69_RS01320	COG1956	GAF domain-containing protein
ISA69_RS01340	COG2814	Major facilitator Superfamily
ISA69_RS01345	COG1414	Transcriptional regulator
ISA69_RS01380	COG0768	penicillin binding
ISA69_RS01385	COG2226	methyltransferase
ISA69_RS01400	COG3716	PTS system mannose fructose sorbose family IID component
ISA69_RS01405	COG3715	PTS system
ISA69_RS01410	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA69_RS01410	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA69_RS01415	COG1253	flavin adenine dinucleotide binding
ISA69_RS01420	COG2200	EAL domain
ISA69_RS01425	COG1760	l-serine dehydratase
ISA69_RS01445	COG0251	oxidation-reduction process
ISA69_RS01450	COG1199	ATP-dependent helicase activity
ISA69_RS01460	COG3065	identical protein binding
ISA69_RS01470	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ISA69_RS01480	COG2894	cell division
ISA69_RS01495	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISA69_RS01525	COG2719	SpoVR family
ISA69_RS01550	COG1619	proteins homologs of microcin C7 resistance protein MccF
ISA69_RS01570	COG4774	siderophore transport
ISA69_RS01585	COG2308	Evidence 4 Homologs of previously reported genes of
ISA69_RS01605	COG3842	ATPase activity
ISA69_RS01610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISA69_RS01615	COG0395	ABC-type sugar transport system, permease component
ISA69_RS01630	COG1940	carbohydrate kinase activity
ISA69_RS01645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISA69_RS01655	COG1174	glycine betaine transport
ISA69_RS01675	COG0583	DNA-binding transcription factor activity
ISA69_RS01680	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ISA69_RS01695	COG1882	Formate acetyltransferase
ISA69_RS01730	COG0583	DNA-binding transcription factor activity
ISA69_RS01760	COG0583	DNA-binding transcription factor activity
ISA69_RS01770	COG0564	pseudouridine synthase activity
ISA69_RS01775	COG3122	Protein conserved in bacteria
ISA69_RS01780	COG2186	Transcriptional regulator
ISA69_RS01785	COG3734	2-keto-3-deoxy-galactonokinase
ISA69_RS01790	COG0800	Aldolase
ISA69_RS01805	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ISA69_RS01840	COG0012	GTP binding
ISA69_RS01860	COG0659	secondary active sulfate transmembrane transporter activity
ISA69_RS01890	COG2890	protein-(glutamine-N5) methyltransferase activity
ISA69_RS01910	COG0387	Pfam Sodium calcium exchanger
ISA69_RS01915	COG4572	Cation transport regulator
ISA69_RS01920	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
ISA69_RS01930	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ISA69_RS01935	COG3707	response regulator
ISA69_RS01940	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISA69_RS01950	COG1116	anion transmembrane transporter activity
ISA69_RS01955	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISA69_RS01955	COG2146	nitrite reductase [NAD(P)H] activity
ISA69_RS01960	COG0243	molybdopterin cofactor binding
ISA69_RS01965	COG4932	domain protein
ISA69_RS01970	COG2197	response regulator
ISA69_RS01975	COG3850	Histidine kinase
ISA69_RS01980	COG2223	nitrite transmembrane transporter activity
ISA69_RS01985	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ISA69_RS01990	COG1140	nitrate reductase beta subunit
ISA69_RS01995	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
ISA69_RS02000	COG2181	nitrate reductase activity
ISA69_RS02010	COG1522	sequence-specific DNA binding
ISA69_RS02040	COG0788	formyltetrahydrofolate deformylase activity
ISA69_RS02050	COG1752	Esterase of the alpha-beta hydrolase superfamily
ISA69_RS02055	COG0745	RESPONSE REGULATOR receiver
ISA69_RS02060	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISA69_RS02065	COG2916	Histone family protein nucleoid-structuring protein H-NS
ISA69_RS02070	COG1435	thymidine kinase activity
ISA69_RS02075	COG1012	belongs to the aldehyde dehydrogenase family
ISA69_RS02075	COG1454	alcohol dehydrogenase
ISA69_RS02085	COG2095	MarC family integral membrane protein
ISA69_RS02090	COG4166	transmembrane transport
ISA69_RS02095	COG0601	transmembrane transport
ISA69_RS02100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISA69_RS02105	COG0444	Belongs to the ABC transporter superfamily
ISA69_RS02115	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISA69_RS02135	COG2353	YceI-like domain
ISA69_RS02140	COG4993	Dehydrogenase
ISA69_RS02145	COG2350	Protein conserved in bacteria
ISA69_RS02155	COG3001	Fructosamine kinase
ISA69_RS02165	COG1105	Belongs to the carbohydrate kinase PfkB family
ISA69_RS02170	COG3137	Salt-induced outer membrane protein
ISA69_RS02210	COG0072	phenylalanine-tRNA ligase activity
ISA69_RS02210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ISA69_RS02220	COG0251	oxidation-reduction process
ISA69_RS02230	COG0583	DNA-binding transcription factor activity
ISA69_RS02250	COG0386	Belongs to the glutathione peroxidase family
ISA69_RS02260	COG0791	NLP P60 protein
ISA69_RS02270	COG4256	Hemin uptake protein
ISA69_RS02275	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISA69_RS02290	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISA69_RS02290	COG0574	Belongs to the PEP-utilizing enzyme family
ISA69_RS02300	COG0628	permease
ISA69_RS02305	COG0247	lactate metabolic process
ISA69_RS02305	COG0277	FAD linked oxidase domain protein
ISA69_RS02310	COG2050	protein possibly involved in aromatic compounds catabolism
ISA69_RS02315	COG2261	transglycosylase associated protein
ISA69_RS02340	COG1120	ATPase activity
ISA69_RS02345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA69_RS02355	COG0583	DNA-binding transcription factor activity
ISA69_RS02380	COG1304	FMN binding
ISA69_RS02390	COG0316	Belongs to the HesB IscA family
ISA69_RS02395	COG0719	Fe-S assembly protein
ISA69_RS02400	COG0396	ATPase activity
ISA69_RS02405	COG0719	Fe-S assembly protein
ISA69_RS02420	COG1376	ErfK ybiS ycfS ynhG family protein
ISA69_RS02445	COG1309	transcriptional regulator
ISA69_RS02450	COG1082	Xylose isomerase domain protein TIM barrel
ISA69_RS02450	COG3185	4-Hydroxyphenylpyruvate dioxygenase
ISA69_RS02455	COG2271	Major facilitator Superfamily
ISA69_RS02460	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ISA69_RS02470	COG1120	ATPase activity
ISA69_RS02475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA69_RS02480	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISA69_RS02485	COG1414	Transcriptional regulator
ISA69_RS02520	COG2814	Major facilitator Superfamily
ISA69_RS02540	COG0583	DNA-binding transcription factor activity
ISA69_RS02545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISA69_RS02565	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISA69_RS02570	COG1116	anion transmembrane transporter activity
ISA69_RS02575	COG4774	siderophore transport
ISA69_RS02580	COG1120	ATPase activity
ISA69_RS02585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA69_RS02590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA69_RS02610	COG0765	amino acid transport
ISA69_RS02615	COG1126	abc transporter atp-binding protein
ISA69_RS02640	COG0641	radical SAM
ISA69_RS02645	COG3119	arylsulfatase activity
ISA69_RS02655	COG1116	anion transmembrane transporter activity
ISA69_RS02675	COG0346	lactoylglutathione lyase activity
ISA69_RS02690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA69_RS02705	COG2814	Major facilitator Superfamily
ISA69_RS02710	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISA69_RS02720	COG1017	nitric oxide dioxygenase activity
ISA69_RS02720	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISA69_RS02745	COG3383	formate dehydrogenase (NAD+) activity
ISA69_RS02750	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
ISA69_RS02760	COG1175	transmembrane transport
ISA69_RS02790	COG4133	protoheme IX ABC transporter activity
ISA69_RS02795	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISA69_RS02800	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISA69_RS02815	COG1138	Cytochrome C-type biogenesis protein
ISA69_RS02820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISA69_RS02825	COG3088	subunit of a heme lyase
ISA69_RS02825	COG4235	cytochrome complex assembly
ISA69_RS02855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISA69_RS02875	COG0583	DNA-binding transcription factor activity
ISA69_RS02905	COG1028	Short-chain dehydrogenase reductase Sdr
ISA69_RS02910	COG2610	gluconate transmembrane transporter activity
ISA69_RS02915	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISA69_RS02925	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ISA69_RS02935	COG0583	DNA-binding transcription factor activity
ISA69_RS02965	COG2814	Major facilitator Superfamily
ISA69_RS03010	COG0277	FAD linked oxidase domain protein
ISA69_RS03015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISA69_RS03040	COG0402	S-adenosylhomocysteine deaminase activity
ISA69_RS03075	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISA69_RS03085	COG1028	Short-chain dehydrogenase reductase Sdr
ISA69_RS03090	COG0531	amino acid
ISA69_RS03095	COG0583	DNA-binding transcription factor activity
ISA69_RS03120	COG4608	Belongs to the ABC transporter superfamily
ISA69_RS03125	COG0444	Belongs to the ABC transporter superfamily
ISA69_RS03155	COG2011	ABC-type metal ion transport system permease component
ISA69_RS03170	COG0346	lactoylglutathione lyase activity
ISA69_RS03175	COG1349	DNA-binding transcription factor activity
ISA69_RS03215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISA69_RS03235	COG0300	oxidoreductase activity
ISA69_RS03275	COG0307	riboflavin synthase, alpha
ISA69_RS03280	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ISA69_RS03285	COG2814	Major facilitator Superfamily
ISA69_RS03290	COG0583	DNA-binding transcription factor activity
ISA69_RS03305	COG2814	Major facilitator Superfamily
ISA69_RS03315	COG2207	Transcriptional regulator
ISA69_RS03320	COG0791	NLP P60 protein
ISA69_RS03325	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ISA69_RS03335	COG0346	lactoylglutathione lyase activity
ISA69_RS03340	COG1902	pentaerythritol trinitrate reductase activity
ISA69_RS03345	COG1309	transcriptional regulator
ISA69_RS03350	COG3313	Fe-S protein
ISA69_RS03355	COG4989	oxidoreductase activity
ISA69_RS03360	COG2032	superoxide dismutase activity
ISA69_RS03365	COG1289	transmembrane transporter activity
ISA69_RS03370	COG1566	PFAM secretion protein HlyD family protein
ISA69_RS03385	COG3706	GGDEF domain
ISA69_RS03400	COG3895	Periplasmic Protein
ISA69_RS03415	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
ISA69_RS03420	COG0625	glutathione transferase activity
ISA69_RS03430	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ISA69_RS03440	COG4659	FMN binding
ISA69_RS03475	COG2723	6-phospho-beta-galactosidase activity
ISA69_RS03485	COG0673	inositol 2-dehydrogenase activity
ISA69_RS03495	COG2814	Major facilitator Superfamily
ISA69_RS03515	COG3038	cytochrome b561
ISA69_RS03535	COG0583	DNA-binding transcription factor activity
ISA69_RS03540	COG3485	protocatechuate 3,4-dioxygenase
ISA69_RS03545	COG3485	protocatechuate 3,4-dioxygenase
ISA69_RS03550	COG5383	Protein conserved in bacteria
ISA69_RS03555	COG2272	Belongs to the type-B carboxylesterase lipase family
ISA69_RS03570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISA69_RS03580	COG1275	C4-dicarboxylate transporter malic acid transport protein
ISA69_RS03585	COG0500	methyltransferase
ISA69_RS03600	COG2207	Transcriptional regulator
ISA69_RS03600	COG3708	Transcriptional regulator
ISA69_RS03605	COG3135	benzoate transporter
ISA69_RS03610	COG1396	sequence-specific DNA binding
ISA69_RS03620	COG0826	peptidase U32
ISA69_RS03640	COG1294	oxidase, subunit
ISA69_RS03645	COG1271	oxidase subunit
ISA69_RS03650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISA69_RS03655	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ISA69_RS03660	COG3842	ATPase activity
ISA69_RS03665	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISA69_RS03670	COG1177	transmembrane transport
ISA69_RS03675	COG1012	belongs to the aldehyde dehydrogenase family
ISA69_RS03705	COG1012	belongs to the aldehyde dehydrogenase family
ISA69_RS03710	COG0747	negative chemotaxis
ISA69_RS03720	COG3238	Protein conserved in bacteria
ISA69_RS03725	COG1247	-acetyltransferase
ISA69_RS03735	COG2130	NADP-dependent
ISA69_RS03750	COG3691	Protein conserved in bacteria
ISA69_RS03755	COG4772	TonB-dependent receptor
ISA69_RS03780	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ISA69_RS03785	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ISA69_RS03790	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ISA69_RS03795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISA69_RS03800	COG1473	amidohydrolase
ISA69_RS03805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISA69_RS03810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA69_RS03820	COG0765	amino acid transport
ISA69_RS03825	COG1126	abc transporter atp-binding protein
ISA69_RS03835	COG2271	Major facilitator Superfamily
ISA69_RS03845	COG1609	Transcriptional regulator
ISA69_RS03850	COG0625	glutathione transferase activity
ISA69_RS03865	COG2211	Major facilitator Superfamily
ISA69_RS03880	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ISA69_RS03885	COG3842	ATPase activity
ISA69_RS03890	COG1840	ABC-type Fe3 transport system, periplasmic component
ISA69_RS03895	COG1178	ABC-type Fe3 transport system permease component
ISA69_RS03900	COG2162	N-hydroxyarylamine O-acetyltransferase activity
ISA69_RS03905	COG2181	nitrate reductase activity
ISA69_RS03910	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
ISA69_RS03915	COG1140	nitrate reductase beta subunit
ISA69_RS03920	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ISA69_RS03940	COG1414	Transcriptional regulator
ISA69_RS03945	COG4948	Mandelate Racemase Muconate Lactonizing
ISA69_RS03950	COG4829	muconolactone delta-isomerase
ISA69_RS03955	COG3485	protocatechuate 3,4-dioxygenase
ISA69_RS03965	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
ISA69_RS03990	COG0437	4 iron, 4 sulfur cluster binding
ISA69_RS03995	COG2864	formate dehydrogenase
ISA69_RS04010	COG2326	polyphosphate kinase activity
ISA69_RS04020	COG2814	Major facilitator Superfamily
ISA69_RS04030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISA69_RS04040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISA69_RS04045	COG0601	transmembrane transport
ISA69_RS04050	COG0747	negative chemotaxis
ISA69_RS04055	COG1064	alcohol dehydrogenase
ISA69_RS04070	COG0488	(ABC) transporter
ISA69_RS04130	COG1028	Short-chain dehydrogenase reductase Sdr
ISA69_RS04135	COG3729	General stress protein
ISA69_RS04145	COG3685	Protein conserved in bacteria
ISA69_RS04155	COG0366	Alpha amylase catalytic
ISA69_RS04165	COG2323	membrane
ISA69_RS04175	COG3111	PFAM Bacterial OB fold (BOF) protein
ISA69_RS04185	COG1764	response to oxidative stress
ISA69_RS04200	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ISA69_RS04205	COG3781	membrane
ISA69_RS04210	COG0243	molybdopterin cofactor binding
ISA69_RS04215	COG0583	DNA-binding transcription factor activity
ISA69_RS04220	COG2814	Major facilitator Superfamily
ISA69_RS04225	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ISA69_RS04245	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ISA69_RS04245	COG0519	Catalyzes the synthesis of GMP from XMP
ISA69_RS04285	COG0596	Alpha beta hydrolase
ISA69_RS04310	COG0076	glutamate decarboxylase activity
ISA69_RS04315	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISA69_RS04320	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISA69_RS04325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISA69_RS04330	COG1116	anion transmembrane transporter activity
ISA69_RS04335	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ISA69_RS04355	COG0673	inositol 2-dehydrogenase activity
ISA69_RS04365	COG1609	Transcriptional regulator
ISA69_RS04370	COG3706	GGDEF domain
ISA69_RS04380	COG0402	S-adenosylhomocysteine deaminase activity
ISA69_RS04385	COG1953	Uracil, thiamine, allantoin
ISA69_RS04425	COG2207	Transcriptional regulator
ISA69_RS04440	COG0583	DNA-binding transcription factor activity
ISA69_RS04475	COG0583	DNA-binding transcription factor activity
ISA69_RS04490	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISA69_RS04560	COG0765	amino acid transport
ISA69_RS04570	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISA69_RS04580	COG2070	2-Nitropropane dioxygenase
ISA69_RS04585	COG0583	DNA-binding transcription factor activity
ISA69_RS04595	COG1902	pentaerythritol trinitrate reductase activity
ISA69_RS04600	COG4529	Protein conserved in bacteria
ISA69_RS04605	COG0477	Major facilitator Superfamily
ISA69_RS04635	COG2223	nitrite transmembrane transporter activity
ISA69_RS04650	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ISA69_RS04660	COG3665	Urea carboxylase-associated protein
ISA69_RS04665	COG0439	Biotin carboxylase
ISA69_RS04680	COG1028	Short-chain dehydrogenase reductase Sdr
ISA69_RS04685	COG0583	DNA-binding transcription factor activity
ISA69_RS04700	COG2197	response regulator
ISA69_RS04745	COG0583	DNA-binding transcription factor activity
ISA69_RS04750	COG0583	DNA-binding transcription factor activity
ISA69_RS04755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISA69_RS04765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISA69_RS04780	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA69_RS04790	COG1609	Transcriptional regulator
ISA69_RS04815	COG0747	negative chemotaxis
ISA69_RS04820	COG0601	transmembrane transport
ISA69_RS04825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISA69_RS04835	COG2814	Major facilitator Superfamily
ISA69_RS04840	COG1566	PFAM secretion protein HlyD family protein
ISA69_RS04880	COG1979	alcohol dehydrogenase
ISA69_RS04885	COG4977	sequence-specific DNA binding
ISA69_RS04895	COG1979	alcohol dehydrogenase
ISA69_RS04900	COG1064	alcohol dehydrogenase
ISA69_RS04915	COG4977	sequence-specific DNA binding
ISA69_RS04930	COG5002	protein histidine kinase activity
ISA69_RS04930	COG3850	Histidine kinase
ISA69_RS05015	COG2186	Transcriptional regulator
ISA69_RS05020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA69_RS05020	COG1263	PTS System
ISA69_RS05030	COG2814	Major facilitator Superfamily
ISA69_RS05035	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA69_RS05035	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA69_RS05050	COG2819	hydrolase of the alpha beta superfamily
ISA69_RS05055	COG3300	MHYT domain
ISA69_RS05055	COG5001	Diguanylate cyclase
ISA69_RS05075	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ISA69_RS05110	COG3188	usher protein
ISA69_RS05120	COG1649	PFAM Uncharacterised BCR, COG1649
ISA69_RS05125	COG3550	peptidyl-serine autophosphorylation
ISA69_RS05130	COG1396	sequence-specific DNA binding
ISA69_RS05135	COG2351	hydroxyisourate hydrolase activity
ISA69_RS05145	COG2233	PERMEase
ISA69_RS05175	COG2207	Transcriptional regulator
ISA69_RS05190	COG4628	conserved protein (DUF2132)
ISA69_RS05210	COG2011	ABC-type metal ion transport system permease component
ISA69_RS05215	COG2070	2-Nitropropane dioxygenase
ISA69_RS05225	COG0477	Major facilitator Superfamily
ISA69_RS05300	COG2199	diguanylate cyclase activity
ISA69_RS05315	COG1012	belongs to the aldehyde dehydrogenase family
ISA69_RS05320	COG0583	DNA-binding transcription factor activity
ISA69_RS05330	COG0039	L-malate dehydrogenase activity
ISA69_RS05335	COG1349	DNA-binding transcription factor activity
ISA69_RS05340	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ISA69_RS05345	COG3395	kinase activity
ISA69_RS05355	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISA69_RS05370	COG2731	YhcH YjgK YiaL family protein
ISA69_RS05400	COG4977	sequence-specific DNA binding
ISA69_RS05410	COG0697	spore germination
ISA69_RS05415	COG2814	Major facilitator Superfamily
ISA69_RS05445	COG0683	leucine binding
ISA69_RS05450	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ISA69_RS05485	COG2223	nitrite transmembrane transporter activity
ISA69_RS05490	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ISA69_RS05505	COG1349	DNA-binding transcription factor activity
ISA69_RS05510	COG2084	Dehydrogenase
ISA69_RS05515	COG3395	kinase activity
ISA69_RS05520	COG0235	Class ii aldolase
ISA69_RS05525	COG3622	Belongs to the hyi family
ISA69_RS05530	COG2610	gluconate transmembrane transporter activity
ISA69_RS05535	COG3708	Transcriptional regulator
ISA69_RS05535	COG2207	Transcriptional regulator
ISA69_RS05550	COG2200	EAL domain
ISA69_RS05555	COG1546	Belongs to the CinA family
ISA69_RS05560	COG0071	Belongs to the small heat shock protein (HSP20) family
ISA69_RS05610	COG1090	epimerase
ISA69_RS05620	COG0583	DNA-binding transcription factor activity
ISA69_RS05630	COG0406	alpha-ribazole phosphatase activity
ISA69_RS05635	COG0583	DNA-binding transcription factor activity
ISA69_RS05660	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ISA69_RS05690	COG4221	oxidoreductase activity
ISA69_RS05695	COG1802	Transcriptional regulator
ISA69_RS05700	COG0589	response to stress
ISA69_RS05705	COG0246	Mannitol dehydrogenase
ISA69_RS05710	COG2271	Major facilitator Superfamily
ISA69_RS05725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISA69_RS05740	COG0243	molybdopterin cofactor binding
ISA69_RS05745	COG0437	4 iron, 4 sulfur cluster binding
ISA69_RS05750	COG3302	dmso reductase anchor subunit
ISA69_RS05765	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ISA69_RS05770	COG1940	carbohydrate kinase activity
ISA69_RS05775	COG0583	DNA-binding transcription factor activity
ISA69_RS05780	COG2814	Major facilitator Superfamily
ISA69_RS05785	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ISA69_RS05795	COG3591	Belongs to the peptidase S1B family
ISA69_RS05815	COG0628	permease
ISA69_RS05845	COG0679	Auxin Efflux Carrier
ISA69_RS05855	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ISA69_RS05865	COG2814	Major facilitator Superfamily
ISA69_RS05880	COG3290	protein histidine kinase activity
ISA69_RS05885	COG4565	transcriptional regulatory protein
ISA69_RS05905	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ISA69_RS05905	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ISA69_RS05915	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISA69_RS05920	COG0596	Alpha beta hydrolase
ISA69_RS05930	COG0183	Belongs to the thiolase family
ISA69_RS05935	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ISA69_RS05945	COG1414	Transcriptional regulator
ISA69_RS05950	COG2840	Smr protein MutS2
ISA69_RS05955	COG0583	DNA-binding transcription factor activity
ISA69_RS05965	COG1473	amidohydrolase
ISA69_RS05970	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ISA69_RS05985	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISA69_RS06000	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ISA69_RS06005	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ISA69_RS06020	COG0531	amino acid
ISA69_RS06030	COG3136	membrane protein required for alginate biosynthesis
ISA69_RS06035	COG0745	RESPONSE REGULATOR receiver
ISA69_RS06050	COG2205	protein histidine kinase activity
ISA69_RS06060	COG0114	fumarate hydratase activity
ISA69_RS06065	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ISA69_RS06065	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ISA69_RS06070	COG1482	cell wall glycoprotein biosynthetic process
ISA69_RS06075	COG5339	Protein conserved in bacteria
ISA69_RS06080	COG1609	Transcriptional regulator
ISA69_RS06085	COG1263	PTS System
ISA69_RS06085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA69_RS06090	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ISA69_RS06120	COG0425	Belongs to the sulfur carrier protein TusA family
ISA69_RS06125	COG5562	phage envelope protein
ISA69_RS06130	COG0401	homolog of Blt101
ISA69_RS06135	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ISA69_RS06140	COG1012	belongs to the aldehyde dehydrogenase family
ISA69_RS06150	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ISA69_RS06155	COG0477	Major facilitator Superfamily
ISA69_RS06160	COG1113	amino acid transport
ISA69_RS06165	COG2988	succinylglutamate desuccinylase activity
ISA69_RS06170	COG3724	N-succinylarginine dihydrolase activity
ISA69_RS06175	COG1012	belongs to the aldehyde dehydrogenase family
ISA69_RS06180	COG3138	arginine N-succinyltransferase
ISA69_RS06185	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISA69_RS06195	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ISA69_RS06210	COG0183	Belongs to the thiolase family
ISA69_RS06220	COG0667	Aldo Keto reductase
ISA69_RS06225	COG2814	Major facilitator Superfamily
ISA69_RS06230	COG0667	Aldo Keto reductase
ISA69_RS06235	COG0583	DNA-binding transcription factor activity
ISA69_RS06260	COG4122	O-methyltransferase activity
ISA69_RS06270	COG1643	Atp-dependent helicase
ISA69_RS06280	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
ISA69_RS06290	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ISA69_RS06295	COG3327	negative regulation of DNA-templated transcription, initiation
ISA69_RS06300	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
ISA69_RS06305	COG0183	Belongs to the thiolase family
ISA69_RS06310	COG2050	protein possibly involved in aromatic compounds catabolism
ISA69_RS06315	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISA69_RS06320	COG1024	Enoyl-CoA hydratase
ISA69_RS06325	COG1024	Enoyl-CoA hydratase
ISA69_RS06330	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISA69_RS06335	COG2151	metal-sulfur cluster biosynthetic enzyme
ISA69_RS06340	COG3396	Phenylacetate-CoA oxygenase
ISA69_RS06345	COG3460	Phenylacetate-CoA oxygenase
ISA69_RS06350	COG3396	Phenylacetate-CoA oxygenase
ISA69_RS06355	COG1012	belongs to the aldehyde dehydrogenase family
ISA69_RS06355	COG2030	dehydratase
ISA69_RS06375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISA69_RS06390	COG2072	flavoprotein involved in K transport
ISA69_RS06395	COG0583	DNA-binding transcription factor activity
ISA69_RS06400	COG1126	abc transporter atp-binding protein
ISA69_RS06410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA69_RS06425	COG1012	belongs to the aldehyde dehydrogenase family
ISA69_RS06430	COG2207	Transcriptional regulator
ISA69_RS06435	COG3784	Protein of unknown function (DUF1318)
ISA69_RS06445	COG2911	Protein conserved in bacteria
ISA69_RS06450	COG0586	Pfam SNARE associated Golgi protein
ISA69_RS06455	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ISA69_RS06460	COG3187	Heat shock protein
ISA69_RS06465	COG3042	response to heat
ISA69_RS06470	COG1013	pyruvate-flavodoxin oxidoreductase activity
ISA69_RS06470	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ISA69_RS06470	COG0674	pyruvate-flavodoxin oxidoreductase activity
ISA69_RS06470	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISA69_RS06475	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ISA69_RS06485	COG0589	response to stress
ISA69_RS06495	COG0513	Belongs to the DEAD box helicase family
ISA69_RS06505	COG1349	DNA-binding transcription factor activity
ISA69_RS06510	COG0673	inositol 2-dehydrogenase activity
ISA69_RS06525	COG1113	amino acid transport
ISA69_RS06530	COG1522	sequence-specific DNA binding
ISA69_RS06540	COG1448	Aminotransferase
ISA69_RS06545	COG2011	ABC-type metal ion transport system permease component
ISA69_RS06550	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ISA69_RS06555	COG1464	Belongs to the NlpA lipoprotein family
ISA69_RS06560	COG0436	Aminotransferase
ISA69_RS06565	COG0604	alcohol dehydrogenase
ISA69_RS06595	COG0583	DNA-binding transcription factor activity
ISA69_RS06615	COG1028	Short-chain dehydrogenase reductase Sdr
ISA69_RS06620	COG1309	transcriptional regulator
ISA69_RS06625	COG1028	Short-chain dehydrogenase reductase Sdr
ISA69_RS06680	COG1388	LysM domain
ISA69_RS06685	COG2801	Transposase and inactivated derivatives
ISA69_RS06695	COG2963	transposase activity
ISA69_RS06700	COG2963	transposase activity
ISA69_RS06710	COG1388	LysM domain
ISA69_RS06710	COG3584	3D domain protein
ISA69_RS06735	COG2885	chlorophyll binding
ISA69_RS06760	COG0693	protein deglycase activity
ISA69_RS06765	COG1028	Short-chain dehydrogenase reductase Sdr
ISA69_RS06770	COG0583	DNA-binding transcription factor activity
ISA69_RS06810	COG0656	L-ascorbic acid biosynthetic process
ISA69_RS06850	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISA69_RS06855	COG0583	DNA-binding transcription factor activity
ISA69_RS06860	COG0583	DNA-binding transcription factor activity
ISA69_RS06865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA69_RS06875	COG0765	amino acid transport
ISA69_RS06885	COG4166	transmembrane transport
ISA69_RS06895	COG2866	Carboxypeptidase
ISA69_RS06900	COG4948	Mandelate Racemase Muconate Lactonizing
ISA69_RS06905	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ISA69_RS06910	COG3180	Ammonia monooxygenase
ISA69_RS06925	COG3106	COG3106 Predicted ATPase
ISA69_RS06935	COG1983	PspC domain protein
ISA69_RS06945	COG1842	Phage shock protein A
ISA69_RS06950	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ISA69_RS06960	COG1473	amidohydrolase
ISA69_RS06975	COG0702	epimerase
ISA69_RS06990	COG4171	peptide transport system, permease
ISA69_RS07005	COG2986	histidine ammonia-lyase
ISA69_RS07035	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ISA69_RS07040	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISA69_RS07040	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISA69_RS07055	COG1349	DNA-binding transcription factor activity
ISA69_RS07065	COG0023	Translation Initiation Factor
ISA69_RS07075	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ISA69_RS07080	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ISA69_RS07085	COG0671	phosphoesterase, PA-phosphatase related
ISA69_RS07095	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ISA69_RS07120	COG0616	signal peptide processing
ISA69_RS07125	COG1028	Short-chain dehydrogenase reductase Sdr
ISA69_RS07130	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
ISA69_RS07140	COG0583	DNA-binding transcription factor activity
ISA69_RS07150	COG0009	L-threonylcarbamoyladenylate synthase
ISA69_RS07160	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ISA69_RS07165	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ISA69_RS07165	COG0512	Glutamine amidotransferase of anthranilate synthase
ISA69_RS07170	COG0134	indole-3-glycerol-phosphate synthase activity
ISA69_RS07170	COG0135	phosphoribosylanthranilate isomerase activity
ISA69_RS07215	COG4774	siderophore transport
ISA69_RS07225	COG3047	cAMP biosynthetic process
ISA69_RS07230	COG0727	PFAM Uncharacterised protein family (UPF0153)
ISA69_RS07260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISA69_RS07265	COG1028	Short-chain dehydrogenase reductase Sdr
ISA69_RS07270	COG1988	membrane-bound metal-dependent
ISA69_RS07275	COG1823	symporter activity
ISA69_RS07285	COG0753	catalase activity
ISA69_RS07295	COG1486	melibiose metabolic process
ISA69_RS07300	COG1917	Cupin 2, conserved barrel domain protein
ISA69_RS07300	COG2169	Transcriptional regulator
ISA69_RS07305	COG1447	Phosphotransferase system cellobiose-specific component IIA
ISA69_RS07310	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA69_RS07320	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA69_RS07325	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISA69_RS07335	COG0322	excinuclease ABC activity
ISA69_RS07340	COG3678	ATP-independent chaperone mediated protein folding
ISA69_RS07350	COG3724	N-succinylarginine dihydrolase activity
ISA69_RS07360	COG3138	arginine N-succinyltransferase
ISA69_RS07370	COG0708	Exodeoxyribonuclease III
ISA69_RS07375	COG0398	Pfam SNARE associated Golgi protein
ISA69_RS07380	COG0398	Pfam SNARE associated Golgi protein
ISA69_RS07385	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISA69_RS07390	COG4134	Bacterial extracellular solute-binding protein
ISA69_RS07395	COG4135	transport system, permease component
ISA69_RS07400	COG4136	ATPase activity
ISA69_RS07405	COG2897	thiosulfate sulfurtransferase activity
ISA69_RS07410	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ISA69_RS07415	COG0494	nUDIX hydrolase
ISA69_RS07420	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ISA69_RS07425	COG3321	synthase
ISA69_RS07425	COG1028	Short-chain dehydrogenase reductase Sdr
ISA69_RS07425	COG0604	alcohol dehydrogenase
ISA69_RS07430	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ISA69_RS07435	COG0709	Synthesizes selenophosphate from selenide and ATP
ISA69_RS07445	COG0778	Nitroreductase
ISA69_RS07450	COG0616	signal peptide processing
ISA69_RS07455	COG0252	asparaginase activity
ISA69_RS07460	COG1335	isochorismatase
ISA69_RS07475	COG3139	Protein of unknown function (DUF1315)
ISA69_RS07495	COG0656	L-ascorbic acid biosynthetic process
ISA69_RS07500	COG3713	MltA-interacting MipA family protein
ISA69_RS07505	COG2766	serine protein kinase
ISA69_RS07515	COG0529	Catalyzes the synthesis of activated sulfate
ISA69_RS07525	COG0386	Belongs to the glutathione peroxidase family
ISA69_RS07560	COG1126	abc transporter atp-binding protein
ISA69_RS07565	COG0765	amino acid transport
ISA69_RS07570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA69_RS07580	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ISA69_RS07595	COG0300	oxidoreductase activity
ISA69_RS07600	COG0583	DNA-binding transcription factor activity
ISA69_RS07605	COG1902	pentaerythritol trinitrate reductase activity
ISA69_RS07615	COG1028	Short-chain dehydrogenase reductase Sdr
ISA69_RS07620	COG0583	DNA-binding transcription factor activity
ISA69_RS07640	COG1283	sodium-dependent phosphate transmembrane transporter activity
ISA69_RS07675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA69_RS07680	COG0765	amino acid transport
ISA69_RS07685	COG1126	abc transporter atp-binding protein
ISA69_RS07690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISA69_RS07695	COG4948	Mandelate Racemase Muconate Lactonizing
ISA69_RS07700	COG0006	proline dipeptidase activity
ISA69_RS07705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISA69_RS07715	COG0436	Aminotransferase
ISA69_RS07725	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ISA69_RS07745	COG0859	PFAM glycosyl transferase family 9
ISA69_RS07750	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ISA69_RS07760	COG2207	Transcriptional regulator
ISA69_RS07765	COG2807	transmembrane transport
ISA69_RS07770	COG0504	CTP synthase activity
ISA69_RS07775	COG1683	Conserved Protein
ISA69_RS07780	COG3189	MarR family transcriptional regulator
ISA69_RS07785	COG3042	response to heat
ISA69_RS07790	COG2199	diguanylate cyclase activity
ISA69_RS07790	COG2203	Gaf domain
ISA69_RS07810	COG3182	Iron-regulated membrane protein
ISA69_RS07820	COG1560	Kdo2-lipid A biosynthetic process
ISA69_RS07830	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ISA69_RS07835	COG3706	GGDEF domain
ISA69_RS07840	COG0583	DNA-binding transcription factor activity
ISA69_RS07845	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ISA69_RS07875	COG2207	Transcriptional regulator
ISA69_RS07890	COG1566	PFAM secretion protein HlyD family protein
ISA69_RS07895	COG1294	oxidase, subunit
ISA69_RS07900	COG1271	oxidase subunit
ISA69_RS07905	COG3546	catalase activity
ISA69_RS07910	COG3685	Protein conserved in bacteria
ISA69_RS07915	COG3685	Protein conserved in bacteria
ISA69_RS07920	COG3729	General stress protein
ISA69_RS07925	COG1063	alcohol dehydrogenase
ISA69_RS07930	COG3813	Protein conserved in bacteria
ISA69_RS07955	COG0640	Transcriptional regulator
ISA69_RS07970	COG0538	isocitrate dehydrogenase activity
ISA69_RS07975	COG4943	cyclic-guanylate-specific phosphodiesterase activity
ISA69_RS07980	COG3706	GGDEF domain
ISA69_RS08065	COG0616	signal peptide processing
ISA69_RS08080	COG1802	Transcriptional regulator
ISA69_RS08080	COG4626	Terminase
ISA69_RS08125	COG3772	lysozyme
ISA69_RS08150	COG1403	HNH endonuclease
ISA69_RS08210	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISA69_RS08220	COG0582	viral genome integration into host DNA
ISA69_RS08225	COG0538	isocitrate dehydrogenase activity
ISA69_RS08230	COG1187	pseudouridine synthase activity
ISA69_RS08250	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ISA69_RS08270	COG2205	protein histidine kinase activity
ISA69_RS08275	COG2850	peptidyl-arginine hydroxylation
ISA69_RS08295	COG1177	transmembrane transport
ISA69_RS08310	COG0318	PFAM AMP-dependent synthetase and ligase
ISA69_RS08315	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ISA69_RS08320	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISA69_RS08325	COG0698	ribose 5-phosphate isomerase
ISA69_RS08340	COG3395	kinase activity
ISA69_RS08355	COG2390	Transcriptional regulator
ISA69_RS08365	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ISA69_RS08375	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISA69_RS08385	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISA69_RS08395	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ISA69_RS08400	COG1388	LysM domain
ISA69_RS08400	COG1376	ErfK ybiS ycfS ynhG family protein
ISA69_RS08415	COG1309	transcriptional regulator
ISA69_RS08430	COG3134	Outer membrane lipoprotein
ISA69_RS08435	COG1252	NADH dehydrogenase
ISA69_RS08460	COG5633	Lipoprotein
ISA69_RS08465	COG0537	adenosine 5'-monophosphoramidase activity
ISA69_RS08475	COG0084	hydrolase, TatD family'
ISA69_RS08480	COG0470	DNA polymerase III
ISA69_RS08490	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ISA69_RS08495	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISA69_RS08500	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISA69_RS08515	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ISA69_RS08535	COG1399	metal-binding, possibly nucleic acid-binding protein
ISA69_RS08540	COG0424	maF-like protein
ISA69_RS08555	COG1530	ribonuclease E activity
ISA69_RS08560	COG0583	DNA-binding transcription factor activity
ISA69_RS08565	COG2814	Major facilitator Superfamily
ISA69_RS08585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISA69_RS08635	COG1560	Kdo2-lipid A biosynthetic process
ISA69_RS08650	COG5645	(Lipo)protein
ISA69_RS08685	COG3381	protein complex oligomerization
ISA69_RS08710	COG1309	transcriptional regulator
ISA69_RS08715	COG0583	DNA-binding transcription factor activity
ISA69_RS08725	COG1335	isochorismatase
ISA69_RS08735	COG1702	phosphate starvation-inducible protein PhoH
ISA69_RS08755	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISA69_RS08765	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ISA69_RS08780	COG1309	transcriptional regulator
ISA69_RS08815	COG2233	PERMEase
ISA69_RS08825	COG3729	General stress protein
ISA69_RS08855	COG1028	Short-chain dehydrogenase reductase Sdr
ISA69_RS08870	COG0531	amino acid
ISA69_RS08875	COG0174	glutamine synthetase
ISA69_RS08880	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ISA69_RS08885	COG1917	Cupin 2, conserved barrel domain protein
ISA69_RS08885	COG1396	sequence-specific DNA binding
ISA69_RS08890	COG1012	belongs to the aldehyde dehydrogenase family
ISA69_RS08895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISA69_RS08900	COG0583	DNA-binding transcription factor activity
ISA69_RS08905	COG0473	3-isopropylmalate dehydrogenase activity
ISA69_RS08910	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ISA69_RS08915	COG4638	Rieske (2fe-2S)
ISA69_RS08920	COG1012	belongs to the aldehyde dehydrogenase family
ISA69_RS08925	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISA69_RS08930	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA69_RS08930	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISA69_RS08930	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA69_RS08935	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISA69_RS08940	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISA69_RS08945	COG1882	Formate acetyltransferase
ISA69_RS08950	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ISA69_RS08955	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISA69_RS08965	COG2207	Transcriptional regulator
ISA69_RS08990	COG2200	EAL domain
ISA69_RS09000	COG0058	SHG alpha-glucan phosphorylase activity
ISA69_RS09015	COG0670	Belongs to the BI1 family
ISA69_RS09030	COG2207	Transcriptional regulator
ISA69_RS09035	COG1881	PFAM PEBP family protein
ISA69_RS09050	COG1832	CoA-binding protein
ISA69_RS09060	COG0210	DNA helicase
ISA69_RS09065	COG3304	Inner membrane component domain
ISA69_RS09070	COG1289	transmembrane transporter activity
ISA69_RS09075	COG3070	regulator of competence-specific genes
ISA69_RS09095	COG1067	ATP-dependent peptidase activity
ISA69_RS09105	COG3130	regulation of translation
ISA69_RS09110	COG3009	Protein conserved in bacteria
ISA69_RS09115	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISA69_RS09115	COG3008	intermembrane lipid transfer
ISA69_RS09120	COG2995	paraquat-inducible protein a
ISA69_RS09125	COG0488	(ABC) transporter
ISA69_RS09135	COG3217	Mosc domain protein beta barrel domain protein
ISA69_RS09135	COG0633	Ferredoxin
ISA69_RS09150	COG0431	NADPH-dependent FMN reductase
ISA69_RS09155	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISA69_RS09160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISA69_RS09165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISA69_RS09175	COG0308	aminopeptidase N
ISA69_RS09180	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ISA69_RS09185	COG1473	amidohydrolase
ISA69_RS09195	COG0814	amino acid
ISA69_RS09215	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ISA69_RS09220	COG1448	Aminotransferase
ISA69_RS09225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISA69_RS09230	COG3108	Peptidase M15
ISA69_RS09235	COG2989	Protein conserved in bacteria
ISA69_RS09245	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
ISA69_RS09255	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ISA69_RS09260	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ISA69_RS09265	COG3173	Aminoglycoside phosphotransferase
ISA69_RS09280	COG3214	Protein conserved in bacteria
ISA69_RS09295	COG2333	competence protein COMEC
ISA69_RS09295	COG0658	competence protein
ISA69_RS09305	COG0539	negative regulation of cytoplasmic translation
ISA69_RS09325	COG2323	membrane
ISA69_RS09330	COG1944	ATP diphosphatase activity
ISA69_RS09335	COG2116	formate transmembrane transporter activity
ISA69_RS09340	COG1882	Formate acetyltransferase
ISA69_RS09345	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ISA69_RS09360	COG0477	Major facilitator Superfamily
ISA69_RS09365	COG3302	dmso reductase anchor subunit
ISA69_RS09370	COG0437	4 iron, 4 sulfur cluster binding
ISA69_RS09380	COG4533	DNA binding
ISA69_RS09390	COG0824	Thioesterase
ISA69_RS09395	COG1555	photosystem II stabilization
ISA69_RS09410	COG1674	ftsk spoiiie
ISA69_RS09410	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ISA69_RS09420	COG0492	ferredoxin-NADP+ reductase activity
ISA69_RS09425	COG4988	ABC transporter
ISA69_RS09430	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ISA69_RS09445	COG0542	response to heat
ISA69_RS09455	COG1278	Cold shock
ISA69_RS09465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA69_RS09470	COG3593	DNA synthesis involved in DNA repair
ISA69_RS09480	COG2431	L-lysine efflux transmembrane transporter activity
ISA69_RS09490	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISA69_RS09500	COG0028	Belongs to the TPP enzyme family
ISA69_RS09505	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ISA69_RS09510	COG0702	epimerase
ISA69_RS09515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISA69_RS09520	COG3023	N-Acetylmuramoyl-L-alanine amidase
ISA69_RS09525	COG5001	Diguanylate cyclase
ISA69_RS09525	COG3706	GGDEF domain
ISA69_RS09525	COG4251	negative regulation of phosphorylation
ISA69_RS09525	COG2203	Gaf domain
ISA69_RS09540	COG1126	abc transporter atp-binding protein
ISA69_RS09545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA69_RS09550	COG4215	(ABC) transporter
ISA69_RS09555	COG4160	amino acid transport
ISA69_RS09560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA69_RS09565	COG5002	protein histidine kinase activity
ISA69_RS09570	COG0745	RESPONSE REGULATOR receiver
ISA69_RS09585	COG1177	transmembrane transport
ISA69_RS09590	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISA69_RS09595	COG3842	ATPase activity
ISA69_RS09600	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ISA69_RS09615	COG0778	Nitroreductase
ISA69_RS09640	COG3226	Transcriptional regulator
ISA69_RS09645	COG0738	Major facilitator superfamily
ISA69_RS09650	COG0561	phosphatase activity
ISA69_RS09655	COG2814	Major facilitator Superfamily
ISA69_RS09660	COG0671	phosphoesterase, PA-phosphatase related
ISA69_RS09665	COG1349	DNA-binding transcription factor activity
ISA69_RS09670	COG1686	Belongs to the peptidase S11 family
ISA69_RS09675	COG0625	glutathione transferase activity
ISA69_RS09680	COG2133	pyrroloquinoline quinone binding
ISA69_RS09715	COG0747	negative chemotaxis
ISA69_RS09725	COG1446	asparaginase
ISA69_RS09730	COG0303	'Molybdopterin
ISA69_RS09735	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ISA69_RS09740	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ISA69_RS09745	COG1882	Formate acetyltransferase
ISA69_RS09750	COG0561	phosphatase activity
ISA69_RS09760	COG1609	Transcriptional regulator
ISA69_RS09765	COG2271	Major facilitator Superfamily
ISA69_RS09775	COG0488	(ABC) transporter
ISA69_RS09785	COG1376	ErfK ybiS ycfS ynhG family protein
ISA69_RS09790	COG2188	Transcriptional regulator
ISA69_RS09795	COG2723	6-phospho-beta-galactosidase activity
ISA69_RS09800	COG0667	Aldo Keto reductase
ISA69_RS09805	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ISA69_RS09820	COG2194	sulfuric ester hydrolase activity
ISA69_RS09825	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ISA69_RS09840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA69_RS09845	COG0765	amino acid transport
ISA69_RS09850	COG1126	abc transporter atp-binding protein
ISA69_RS09855	COG0668	transmembrane transport
ISA69_RS09865	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ISA69_RS09875	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ISA69_RS09885	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ISA69_RS09890	COG1199	ATP-dependent helicase activity
ISA69_RS09895	COG0513	Belongs to the DEAD box helicase family
ISA69_RS09900	COG3958	Transketolase
ISA69_RS09905	COG3959	Transketolase, thiamine diphosphate binding domain
ISA69_RS09910	COG1028	Short-chain dehydrogenase reductase Sdr
ISA69_RS09915	COG2271	Major facilitator Superfamily
ISA69_RS09920	COG0583	DNA-binding transcription factor activity
ISA69_RS09925	COG1309	transcriptional regulator
ISA69_RS09930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA69_RS09935	COG1131	(ABC) transporter
ISA69_RS09940	COG0842	Transport permease protein
ISA69_RS09945	COG0842	Transport permease protein
ISA69_RS09955	COG3568	Endonuclease Exonuclease Phosphatase
ISA69_RS09960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISA69_RS09965	COG0392	lysyltransferase activity
ISA69_RS09970	COG0670	Belongs to the BI1 family
ISA69_RS09975	COG0314	molybdopterin synthase activity
ISA69_RS09980	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ISA69_RS09990	COG0521	Mo-molybdopterin cofactor biosynthetic process
ISA69_RS10015	COG0642	Histidine kinase
ISA69_RS10040	COG2226	methyltransferase
ISA69_RS10055	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ISA69_RS10060	COG1881	PFAM PEBP family protein
ISA69_RS10100	COG4677	pectinesterase activity
ISA69_RS10110	COG0589	response to stress
ISA69_RS10115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA69_RS10145	COG0789	Transcriptional regulator
ISA69_RS10150	COG2200	EAL domain
ISA69_RS10175	COG0561	phosphatase activity
ISA69_RS10185	COG4149	molybdate abc transporter
ISA69_RS10190	COG0725	ABC transporter, periplasmic molybdate-binding protein
ISA69_RS10200	COG3585	molybdate ion transport
ISA69_RS10200	COG2005	Transcriptional regulator
ISA69_RS10205	COG1119	ATPase activity
ISA69_RS10215	COG1085	galactose-1-phosphate uridylyltransferase
ISA69_RS10225	COG2017	converts alpha-aldose to the beta-anomer
ISA69_RS10235	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISA69_RS10245	COG1230	cation diffusion facilitator family transporter
ISA69_RS10250	COG3201	nicotinamide mononucleotide transporter
ISA69_RS10255	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ISA69_RS10300	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ISA69_RS10305	COG2885	chlorophyll binding
ISA69_RS10315	COG3064	Membrane
ISA69_RS10315	COG3064	Membrane
ISA69_RS10320	COG0848	biopolymer transport protein
ISA69_RS10325	COG0811	peptide transport
ISA69_RS10330	COG0824	Thioesterase
ISA69_RS10335	COG3790	cyd operon protein YbgE
ISA69_RS10340	COG4890	Cyd operon protein YbgT
ISA69_RS10345	COG1294	oxidase, subunit
ISA69_RS10350	COG1271	oxidase subunit
ISA69_RS10355	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ISA69_RS10365	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISA69_RS10370	COG0567	Dehydrogenase, E1 component
ISA69_RS10375	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ISA69_RS10380	COG1053	succinate dehydrogenase
ISA69_RS10385	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ISA69_RS10390	COG2009	succinate dehydrogenase
ISA69_RS10415	COG1984	allophanate hydrolase subunit 2
ISA69_RS10420	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ISA69_RS10465	COG2205	protein histidine kinase activity
ISA69_RS10470	COG0745	RESPONSE REGULATOR receiver
ISA69_RS10480	COG0033	Phosphoglucomutase
ISA69_RS10490	COG0596	Alpha beta hydrolase
ISA69_RS10505	COG0735	belongs to the Fur family
ISA69_RS10510	COG0583	DNA-binding transcription factor activity
ISA69_RS10515	COG1053	succinate dehydrogenase
ISA69_RS10560	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ISA69_RS10565	COG1846	Transcriptional regulator
ISA69_RS10565	COG1940	carbohydrate kinase activity
ISA69_RS10570	COG0647	UMP catabolic process
ISA69_RS10575	COG0367	asparagine synthase
ISA69_RS10615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISA69_RS10625	COG1702	phosphate starvation-inducible protein PhoH
ISA69_RS10650	COG0765	amino acid transport
ISA69_RS10655	COG0765	amino acid transport
ISA69_RS10660	COG1126	abc transporter atp-binding protein
ISA69_RS10675	COG2888	peptidyl-tyrosine sulfation
ISA69_RS10690	COG1466	dna polymerase III delta subunit
ISA69_RS10705	COG0799	negative regulation of ribosome biogenesis
ISA69_RS10715	COG0768	penicillin binding
ISA69_RS10720	COG0772	Belongs to the SEDS family
ISA69_RS10725	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ISA69_RS10730	COG1686	Belongs to the peptidase S11 family
ISA69_RS10745	COG0583	DNA-binding transcription factor activity
ISA69_RS10755	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ISA69_RS10760	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISA69_RS10780	COG3069	C4-dicarboxylate transmembrane transporter activity
ISA69_RS10785	COG3719	Belongs to the RNase T2 family
ISA69_RS10790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISA69_RS10810	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISA69_RS10815	COG0583	DNA-binding transcription factor activity
ISA69_RS10820	COG3969	phosphoadenosine phosphosulfate
ISA69_RS10825	COG1475	DNA binding
ISA69_RS10830	COG0436	Aminotransferase
ISA69_RS10855	COG1129	ABC transporter
ISA69_RS10860	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA69_RS10865	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA69_RS10875	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISA69_RS10890	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ISA69_RS10900	COG0402	S-adenosylhomocysteine deaminase activity
ISA69_RS10910	COG0483	inositol monophosphate 1-phosphatase activity
ISA69_RS10915	COG2271	Major facilitator Superfamily
ISA69_RS10945	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA69_RS10950	COG1129	ABC transporter
ISA69_RS10955	COG0371	Dehydrogenase
ISA69_RS10960	COG1028	Short-chain dehydrogenase reductase Sdr
ISA69_RS10975	COG2879	small protein
ISA69_RS10980	COG1966	Carbon starvation protein
ISA69_RS10990	COG1028	Short-chain dehydrogenase reductase Sdr
ISA69_RS10995	COG1535	isochorismatase
ISA69_RS10995	COG3433	isochorismatase activity
ISA69_RS11000	COG1021	2,3-dihydroxybenzoate-AMP ligase
ISA69_RS11005	COG1169	isochorismate synthase
ISA69_RS11010	COG4592	Periplasmic binding protein
ISA69_RS11020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA69_RS11025	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA69_RS11030	COG1120	ATPase activity
ISA69_RS11035	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
ISA69_RS11035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISA69_RS11040	COG3251	PFAM MbtH domain protein
ISA69_RS11045	COG2382	esterase
ISA69_RS11050	COG4771	TonB-dependent receptor
ISA69_RS11055	COG2977	Belongs to the P-Pant transferase superfamily
ISA69_RS11060	COG3958	Transketolase
ISA69_RS11065	COG3959	Transketolase, thiamine diphosphate binding domain
ISA69_RS11070	COG2390	Transcriptional regulator
ISA69_RS11075	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ISA69_RS11080	COG1879	ABC-type sugar transport system periplasmic component
ISA69_RS11090	COG1129	ABC transporter
ISA69_RS11095	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA69_RS11105	COG1028	Short-chain dehydrogenase reductase Sdr
ISA69_RS11115	COG0583	DNA-binding transcription factor activity
ISA69_RS11120	COG0668	transmembrane transport
ISA69_RS11130	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ISA69_RS11175	COG0747	negative chemotaxis
ISA69_RS11180	COG0601	transmembrane transport
ISA69_RS11185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISA69_RS11190	COG0444	Belongs to the ABC transporter superfamily
ISA69_RS11195	COG4608	Belongs to the ABC transporter superfamily
ISA69_RS11200	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ISA69_RS11205	COG4221	oxidoreductase activity
ISA69_RS11215	COG4215	(ABC) transporter
ISA69_RS11220	COG0765	amino acid transport
ISA69_RS11225	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ISA69_RS11240	COG0697	spore germination
ISA69_RS11255	COG4608	Belongs to the ABC transporter superfamily
ISA69_RS11260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISA69_RS11270	COG4166	transmembrane transport
ISA69_RS11280	COG3698	Phosphodiester glycosidase
ISA69_RS11320	COG2315	Protein conserved in bacteria
ISA69_RS11325	COG0778	Nitroreductase
ISA69_RS11350	COG0477	Major facilitator Superfamily
ISA69_RS11355	COG0668	transmembrane transport
ISA69_RS11360	COG1609	Transcriptional regulator
ISA69_RS11370	COG0673	inositol 2-dehydrogenase activity
ISA69_RS11380	COG2211	Major facilitator Superfamily
ISA69_RS11385	COG1113	amino acid transport
ISA69_RS11400	COG1012	belongs to the aldehyde dehydrogenase family
ISA69_RS11405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISA69_RS11415	COG0531	amino acid
ISA69_RS11450	COG0667	Aldo Keto reductase
ISA69_RS11455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA69_RS11460	COG1473	amidohydrolase
ISA69_RS11485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA69_RS11490	COG1120	ATPase activity
ISA69_RS11495	COG1566	PFAM secretion protein HlyD family protein
ISA69_RS11540	COG4211	Belongs to the binding-protein-dependent transport system permease family
ISA69_RS11545	COG1129	ABC transporter
ISA69_RS11560	COG0673	inositol 2-dehydrogenase activity
ISA69_RS11595	COG3104	oligopeptide transport
ISA69_RS11600	COG1982	Orn Lys Arg decarboxylase major
ISA69_RS11605	COG0531	amino acid
ISA69_RS11610	COG3710	Transcriptional regulator
ISA69_RS11620	COG1560	Kdo2-lipid A biosynthetic process
ISA69_RS11635	COG3188	usher protein
ISA69_RS11640	COG3121	Chaperone
ISA69_RS11645	COG3539	Fimbrial protein
ISA69_RS11710	COG2501	S4 domain
ISA69_RS11720	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISA69_RS11735	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ISA69_RS11740	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ISA69_RS11760	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ISA69_RS11765	COG4181	ATPase activity
ISA69_RS11770	COG2755	lipolytic protein G-D-S-L family
ISA69_RS11775	COG0300	oxidoreductase activity
ISA69_RS11780	COG3118	belongs to the thioredoxin family
ISA69_RS11785	COG0390	transport system, permease component
ISA69_RS11790	COG4619	ABC transporter
ISA69_RS11795	COG0330	HflC and HflK could
ISA69_RS11800	COG1585	Membrane protein implicated in regulation of membrane protease activity
ISA69_RS11815	COG3735	TraB family
ISA69_RS11820	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ISA69_RS11830	COG2223	nitrite transmembrane transporter activity
ISA69_RS11835	COG4651	solute:proton antiporter activity
ISA69_RS11835	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISA69_RS11840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISA69_RS11880	COG2832	Protein of unknown function (DUF454)
ISA69_RS11885	COG3923	Primosomal replication protein n
ISA69_RS11895	COG5464	transposase or invertase
ISA69_RS11900	COG1196	nuclear chromosome segregation
ISA69_RS11900	COG3264	Mechanosensitive ion channel
ISA69_RS11905	COG1309	transcriptional regulator
ISA69_RS11910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA69_RS11915	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISA69_RS11930	COG0110	maltose O-acetyltransferase activity
ISA69_RS11980	COG1874	Beta-galactosidase
ISA69_RS11985	COG3867	Arabinogalactan endo-beta-1,4-galactanase
ISA69_RS11990	COG3833	ABC-type maltose transport systems, permease component
ISA69_RS11995	COG1175	transmembrane transport
ISA69_RS12000	COG2182	Extracellular solute-binding protein
ISA69_RS12010	COG4943	cyclic-guanylate-specific phosphodiesterase activity
ISA69_RS12025	COG2364	Membrane
ISA69_RS12055	COG3695	enzyme binding
ISA69_RS12060	COG3126	Type III secretion system lipoprotein chaperone (YscW)
ISA69_RS12065	COG1946	Acyl-CoA thioesterase
ISA69_RS12070	COG0004	ammonium transporteR
ISA69_RS12075	COG0347	Belongs to the P(II) protein family
ISA69_RS12080	COG1132	(ABC) transporter
ISA69_RS12085	COG1132	(ABC) transporter
ISA69_RS12090	COG1522	sequence-specific DNA binding
ISA69_RS12105	COG4533	DNA binding
ISA69_RS12115	COG0824	Thioesterase
ISA69_RS12120	COG1555	photosystem II stabilization
ISA69_RS12125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISA69_RS12130	COG0776	regulation of translation
ISA69_RS12135	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ISA69_RS12155	COG0271	Belongs to the BolA IbaG family
ISA69_RS12160	COG3056	Lipoprotein
ISA69_RS12165	COG2223	nitrite transmembrane transporter activity
ISA69_RS12170	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ISA69_RS12175	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISA69_RS12180	COG1845	cytochrome c oxidase, subunit III
ISA69_RS12185	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ISA69_RS12200	COG1414	Transcriptional regulator
ISA69_RS12210	COG1053	succinate dehydrogenase
ISA69_RS12220	COG1053	succinate dehydrogenase
ISA69_RS12235	COG0673	inositol 2-dehydrogenase activity
ISA69_RS12240	COG2814	Major facilitator Superfamily
ISA69_RS12250	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ISA69_RS12275	COG0142	geranyltranstransferase activity
ISA69_RS12285	COG0667	Aldo Keto reductase
ISA69_RS12290	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ISA69_RS12295	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ISA69_RS12310	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISA69_RS12310	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISA69_RS12320	COG4238	major outer membrane lipoprotein
ISA69_RS12340	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISA69_RS12345	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISA69_RS12350	COG1862	Preprotein translocase
ISA69_RS12375	COG0450	alkyl hydroperoxide reductase
ISA69_RS12385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA69_RS12400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISA69_RS12410	COG1228	amidohydrolase
ISA69_RS12420	COG1335	isochorismatase
ISA69_RS12425	COG0583	DNA-binding transcription factor activity
ISA69_RS12430	COG0366	Alpha amylase catalytic
ISA69_RS12460	COG0420	3'-5' exonuclease activity
ISA69_RS12465	COG0419	ATPase involved in DNA repair
ISA69_RS12470	COG1940	carbohydrate kinase activity
ISA69_RS12485	COG4126	flavin adenine dinucleotide binding
ISA69_RS12495	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ISA69_RS12500	COG3416	Protein conserved in bacteria
ISA69_RS12510	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ISA69_RS12520	COG1785	Belongs to the alkaline phosphatase family
ISA69_RS12560	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
ISA69_RS12565	COG1335	isochorismatase
ISA69_RS12570	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ISA69_RS12575	COG0113	porphobilinogen synthase activity
ISA69_RS12585	COG2175	clavaminate synthase activity
ISA69_RS12590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISA69_RS12595	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
ISA69_RS12600	COG4521	taurine ABC transporter
ISA69_RS12605	COG2040	homocysteine
ISA69_RS12610	COG0833	amino acid
ISA69_RS12625	COG4303	Ethanolamine ammonia lyase large subunit
ISA69_RS12630	COG4302	ethanolamine ammonia-lyase activity
ISA69_RS12670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA69_RS12675	COG1126	abc transporter atp-binding protein
ISA69_RS12680	COG4597	amino acid ABC transporter
ISA69_RS12685	COG0765	amino acid transport
ISA69_RS12700	COG3188	usher protein
ISA69_RS12725	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ISA69_RS12735	COG3639	organic phosphonate transmembrane transporter activity
ISA69_RS12750	COG0791	NLP P60 protein
ISA69_RS12835	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ISA69_RS12840	COG0022	dehydrogenase e1 component
ISA69_RS12845	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISA69_RS12850	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISA69_RS12860	COG0625	glutathione transferase activity
ISA69_RS12865	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ISA69_RS12880	COG0579	oxidoreductase
ISA69_RS12885	COG1012	belongs to the aldehyde dehydrogenase family
ISA69_RS12890	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISA69_RS12895	COG1113	amino acid transport
ISA69_RS12900	COG1802	Transcriptional regulator
ISA69_RS12920	COG2195	Cleaves the N-terminal amino acid of tripeptides
ISA69_RS12925	COG0454	-acetyltransferase
ISA69_RS12940	COG2991	Protein conserved in bacteria
ISA69_RS12955	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ISA69_RS12960	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ISA69_RS12975	COG3034	peptidoglycan biosynthetic process
ISA69_RS12980	COG0121	glutamine amidotransferase
ISA69_RS12990	COG1960	acyl-CoA dehydrogenase activity
ISA69_RS12995	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISA69_RS13010	COG0583	DNA-binding transcription factor activity
ISA69_RS13030	COG2226	methyltransferase
ISA69_RS13040	COG0741	lytic transglycosylase activity
ISA69_RS13040	COG1388	LysM domain
ISA69_RS13045	COG2226	methyltransferase
ISA69_RS13055	COG2814	Major facilitator Superfamily
ISA69_RS13060	COG0583	DNA-binding transcription factor activity
ISA69_RS13065	COG0656	L-ascorbic acid biosynthetic process
ISA69_RS13100	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ISA69_RS13110	COG2011	ABC-type metal ion transport system permease component
ISA69_RS13115	COG1464	Belongs to the NlpA lipoprotein family
ISA69_RS13125	COG1720	tRNA m6t6A37 methyltransferase activity
ISA69_RS13135	COG0791	NLP P60 protein
ISA69_RS13160	COG4568	rho-dependent transcription termination
ISA69_RS13170	COG0346	lactoylglutathione lyase activity
ISA69_RS13175	COG1982	Orn Lys Arg decarboxylase major
ISA69_RS13215	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
ISA69_RS13225	COG0750	zinc metalloprotease
ISA69_RS13230	COG0575	Belongs to the CDS family
ISA69_RS13265	COG0024	Methionine aminopeptidase
ISA69_RS13270	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ISA69_RS13285	COG3835	regulator
ISA69_RS13290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISA69_RS13310	COG2860	membrane
ISA69_RS13330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA69_RS13335	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISA69_RS13340	COG1120	ATPase activity
ISA69_RS13345	COG4774	siderophore transport
ISA69_RS13350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISA69_RS13445	COG1643	Atp-dependent helicase
ISA69_RS13450	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ISA69_RS13470	COG0617	tRNA 3'-terminal CCA addition
ISA69_RS13475	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ISA69_RS13495	COG0726	polysaccharide deacetylase
ISA69_RS13500	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA69_RS13505	COG0842	Transport permease protein
ISA69_RS13510	COG1131	(ABC) transporter
ISA69_RS13515	COG0288	reversible hydration of carbon dioxide
ISA69_RS13530	COG4993	Dehydrogenase
ISA69_RS13535	COG2132	Multicopper oxidase
ISA69_RS13550	COG0545	Peptidyl-prolyl cis-trans isomerase
ISA69_RS13575	COG3064	Membrane
ISA69_RS13590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISA69_RS13595	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISA69_RS13600	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ISA69_RS13605	COG2186	Transcriptional regulator
ISA69_RS13610	COG1113	amino acid transport
ISA69_RS13615	COG2211	Major facilitator Superfamily
ISA69_RS13620	COG3940	Belongs to the glycosyl hydrolase 43 family
ISA69_RS13625	COG3725	Membrane protein required for beta-lactamase induction
ISA69_RS13630	COG3023	N-Acetylmuramoyl-L-alanine amidase
ISA69_RS13640	COG4969	Belongs to the N-Me-Phe pilin family
ISA69_RS13645	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISA69_RS13650	COG1459	type II secretion system
ISA69_RS13675	COG0494	nUDIX hydrolase
ISA69_RS13695	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ISA69_RS13700	COG0849	cell division
ISA69_RS13710	COG1181	Belongs to the D-alanine--D-alanine ligase family
ISA69_RS13725	COG0772	Belongs to the SEDS family
ISA69_RS13740	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ISA69_RS13750	COG0768	penicillin binding
ISA69_RS13770	COG1609	Transcriptional regulator
ISA69_RS13780	COG0028	Belongs to the TPP enzyme family
ISA69_RS13820	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ISA69_RS13825	COG0738	Major facilitator superfamily
ISA69_RS13835	COG0583	DNA-binding transcription factor activity
ISA69_RS13840	COG2271	Major facilitator Superfamily
ISA69_RS13845	COG2814	Major facilitator Superfamily
ISA69_RS13865	COG1178	ABC-type Fe3 transport system permease component
ISA69_RS13875	COG0586	Pfam SNARE associated Golgi protein
ISA69_RS13895	COG0235	Class ii aldolase
ISA69_RS13900	COG0417	DNA replication proofreading
ISA69_RS13910	COG0564	pseudouridine synthase activity
ISA69_RS13920	COG3493	citrate carrier protein
ISA69_RS13935	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ISA69_RS13940	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ISA69_RS13950	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ISA69_RS13985	COG2271	Major facilitator Superfamily
ISA69_RS13990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ISA69_RS13995	COG1609	Transcriptional regulator
ISA69_RS14000	COG1028	Short-chain dehydrogenase reductase Sdr
ISA69_RS14005	COG3265	gluconokinase activity
ISA69_RS14010	COG2731	YhcH YjgK YiaL family protein
ISA69_RS14025	COG0505	Belongs to the CarA family
ISA69_RS14105	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ISA69_RS14110	COG0471	metal ion transport
ISA69_RS14115	COG0471	metal ion transport
ISA69_RS14120	COG2828	Protein conserved in bacteria
ISA69_RS14125	COG0583	DNA-binding transcription factor activity
ISA69_RS14140	COG1047	Peptidyl-prolyl cis-trans
ISA69_RS14155	COG0196	riboflavin kinase activity
ISA69_RS14165	COG0583	DNA-binding transcription factor activity
ISA69_RS14190	COG4735	regulation of single-species biofilm formation
ISA69_RS14195	COG1584	GPR1 FUN34 yaaH family protein
ISA69_RS14200	COG0477	Major facilitator Superfamily
ISA69_RS14205	COG0521	Mo-molybdopterin cofactor biosynthetic process
ISA69_RS14210	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISA69_RS14215	COG1115	amino acid carrier protein
ISA69_RS14230	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ISA69_RS14240	COG0527	aspartate kinase activity
ISA69_RS14240	COG0460	homoserine dehydrogenase
ISA69_RS14250	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ISA69_RS14260	COG0745	RESPONSE REGULATOR receiver
ISA69_RS14265	COG4452	Inner membrane protein CreD
ISA69_RS14270	COG2205	protein histidine kinase activity
ISA69_RS14275	COG0745	RESPONSE REGULATOR receiver
ISA69_RS14280	COG3045	CreA protein
ISA69_RS14285	COG2207	Transcriptional regulator
ISA69_RS14285	COG3708	Transcriptional regulator
ISA69_RS14305	COG0741	lytic transglycosylase activity
ISA69_RS14310	COG0488	(ABC) transporter
ISA69_RS14320	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ISA69_RS14325	COG0560	Phosphoserine phosphatase
ISA69_RS14330	COG3726	membrane protein affecting hemolysin expression
ISA69_RS14360	COG0084	hydrolase, TatD family'
ISA69_RS14365	COG4667	esterase of the alpha-beta hydrolase superfamily
ISA69_RS14375	COG2823	Periplasmic or secreted lipoprotein
ISA69_RS14385	COG1011	Hydrolase
ISA69_RS14390	COG0456	acetyltransferase
ISA69_RS14395	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
ISA69_RS14430	COG3706	GGDEF domain
ISA69_RS14435	COG4114	ferric iron reductase
ISA69_RS14440	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA69_RS14445	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ISA69_RS14450	COG2197	response regulator
ISA69_RS14455	COG2197	response regulator
ISA69_RS14460	COG1917	Cupin 2, conserved barrel domain protein
ISA69_RS14460	COG2169	Transcriptional regulator
ISA69_RS14470	COG2966	Psort location CytoplasmicMembrane, score
ISA69_RS14485	COG1484	DNA-dependent DNA replication
ISA69_RS14500	COG5464	transposase or invertase
ISA69_RS14510	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ISA69_RS14515	COG3716	PTS system mannose fructose sorbose family IID component
ISA69_RS14520	COG3715	PTS system
ISA69_RS14535	COG3933	PFAM sigma-54 factor interaction domain-containing protein
ISA69_RS14535	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ISA69_RS14545	COG1063	alcohol dehydrogenase
ISA69_RS14550	COG1802	Transcriptional regulator
ISA69_RS14555	COG2271	Major facilitator Superfamily
ISA69_RS14560	COG0456	acetyltransferase
ISA69_RS14560	COG1214	PFAM Peptidase M22, glycoprotease
ISA69_RS14575	COG0531	amino acid
ISA69_RS14580	COG1012	belongs to the aldehyde dehydrogenase family
ISA69_RS14585	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISA69_RS14615	COG1846	Transcriptional regulator
ISA69_RS14625	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISA69_RS14635	COG1012	belongs to the aldehyde dehydrogenase family
ISA69_RS14640	COG3384	dioxygenase
ISA69_RS14650	COG3971	2-oxopent-4-enoate hydratase activity
ISA69_RS14670	COG2368	4-hydroxyphenylacetate
ISA69_RS14675	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ISA69_RS14695	COG3210	domain, Protein
ISA69_RS14700	COG2831	hemolysin activation secretion protein
ISA69_RS14705	COG1966	Carbon starvation protein
ISA69_RS14710	COG2879	small protein
ISA69_RS14715	COG0523	cobalamin synthesis protein
ISA69_RS14730	COG1012	belongs to the aldehyde dehydrogenase family
ISA69_RS14735	COG5464	transposase or invertase
ISA69_RS14740	COG1917	Cupin 2, conserved barrel domain protein
ISA69_RS14740	COG2207	Transcriptional regulator
ISA69_RS14750	COG2733	membrane
ISA69_RS14765	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
ISA69_RS14770	COG1924	4 iron, 4 sulfur cluster binding
ISA69_RS14780	COG1473	amidohydrolase
ISA69_RS14785	COG0700	Nucleoside recognition
ISA69_RS14790	COG3366	ferrous iron transmembrane transporter activity
ISA69_RS14795	COG0583	DNA-binding transcription factor activity
ISA69_RS14805	COG1566	PFAM secretion protein HlyD family protein
ISA69_RS14815	COG5457	Domain of unknown function (DUF1127)
ISA69_RS14820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISA69_RS14830	COG0583	DNA-binding transcription factor activity
ISA69_RS14835	COG2249	NAD(P)H dehydrogenase (quinone) activity
ISA69_RS14870	COG1454	alcohol dehydrogenase
ISA69_RS14870	COG1012	belongs to the aldehyde dehydrogenase family
ISA69_RS14885	COG1882	Formate acetyltransferase
ISA69_RS14890	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ISA69_RS14900	COG4869	propanediol catabolic process
ISA69_RS14925	COG3706	GGDEF domain
ISA69_RS14930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA69_RS14935	COG1129	ABC transporter
ISA69_RS14935	COG0842	Transport permease protein
ISA69_RS14940	COG0842	Transport permease protein
ISA69_RS14975	COG2850	peptidyl-arginine hydroxylation
ISA69_RS14980	COG5002	protein histidine kinase activity
ISA69_RS14985	COG0745	RESPONSE REGULATOR receiver
ISA69_RS14990	COG1538	Outer membrane efflux protein
ISA69_RS14995	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA69_RS15000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA69_RS15005	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISA69_RS15015	COG3040	lipid binding
ISA69_RS15020	COG0789	Transcriptional regulator
ISA69_RS15025	COG3631	Ketosteroid isomerase-related protein
ISA69_RS15030	COG0300	oxidoreductase activity
ISA69_RS15045	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ISA69_RS15065	COG3272	Protein of unknown function (DUF1722)
ISA69_RS15070	COG4580	involved in the transport of maltose and maltodextrins
ISA69_RS15080	COG2211	Major facilitator Superfamily
ISA69_RS15085	COG3507	Belongs to the glycosyl hydrolase 43 family
ISA69_RS15140	COG0288	reversible hydration of carbon dioxide
ISA69_RS15145	COG0659	secondary active sulfate transmembrane transporter activity
ISA69_RS15150	COG1064	alcohol dehydrogenase
ISA69_RS15155	COG1175	transmembrane transport
ISA69_RS15160	COG0395	ABC-type sugar transport system, permease component
ISA69_RS15165	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ISA69_RS15170	COG3842	ATPase activity
ISA69_RS15175	COG1653	transport
ISA69_RS15185	COG1082	Xylose isomerase domain protein TIM barrel
ISA69_RS15195	COG3962	Belongs to the TPP enzyme family
ISA69_RS15200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISA69_RS15205	COG0837	glucose binding
ISA69_RS15205	COG1737	Transcriptional regulator
ISA69_RS15210	COG3718	enzyme involved in inositol metabolism
ISA69_RS15225	COG0433	COG0433 Predicted ATPase
ISA69_RS15230	COG0795	lipopolysaccharide-transporting ATPase activity
ISA69_RS15235	COG0795	lipopolysaccharide-transporting ATPase activity
ISA69_RS15245	COG2927	DNA polymerase III (CHI subunit)
ISA69_RS15250	COG0525	valine-tRNA ligase activity
ISA69_RS15275	COG2731	YhcH YjgK YiaL family protein
ISA69_RS15310	COG1263	PTS System
ISA69_RS15310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA69_RS15315	COG0366	Alpha amylase catalytic
ISA69_RS15325	COG0602	queuosine metabolic process
ISA69_RS15330	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA69_RS15330	COG3711	transcriptional antiterminator
ISA69_RS15335	COG2706	6-phosphogluconolactonase activity
ISA69_RS15350	COG3964	amidohydrolase
ISA69_RS15390	COG0312	modulator of DNA gyrase
ISA69_RS15415	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ISA69_RS15425	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA69_RS15430	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA69_RS15435	COG1129	ABC transporter
ISA69_RS15440	COG1879	ABC-type sugar transport system periplasmic component
ISA69_RS15455	COG2105	PFAM AIG2 family protein
ISA69_RS15460	COG2911	Protein conserved in bacteria
ISA69_RS15465	COG0729	surface antigen
ISA69_RS15480	COG1914	H( )-stimulated, divalent metal cation uptake system
ISA69_RS15485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISA69_RS15490	COG1609	Transcriptional regulator
ISA69_RS15500	COG1253	flavin adenine dinucleotide binding
ISA69_RS15515	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ISA69_RS15530	COG1733	regulation of RNA biosynthetic process
ISA69_RS15535	COG0702	epimerase
ISA69_RS15545	COG0697	spore germination
ISA69_RS15555	COG1113	amino acid transport
ISA69_RS15560	COG0545	Peptidyl-prolyl cis-trans isomerase
ISA69_RS15565	COG3061	Opacity-associated protein A
ISA69_RS15575	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ISA69_RS15580	COG2965	DNA replication, synthesis of RNA primer
ISA69_RS15640	COG1073	alpha beta
ISA69_RS15645	COG3650	response to hydrogen peroxide
ISA69_RS15655	COG1960	acyl-CoA dehydrogenase activity
ISA69_RS15660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISA69_RS15665	COG0557	exoribonuclease II activity
ISA69_RS15680	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ISA69_RS15690	COG0330	HflC and HflK could
ISA69_RS15695	COG0330	HflC and HflK could
ISA69_RS15700	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ISA69_RS15720	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISA69_RS15725	COG0802	atpase or kinase
ISA69_RS15730	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ISA69_RS15730	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ISA69_RS15735	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ISA69_RS15755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA69_RS15775	COG1511	domain protein
ISA69_RS15775	COG3264	Mechanosensitive ion channel
ISA69_RS15790	COG1053	succinate dehydrogenase
ISA69_RS15795	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ISA69_RS15815	COG2076	Multidrug Resistance protein
ISA69_RS15835	COG1509	lysine 2,3-aminomutase activity
ISA69_RS15900	COG0531	amino acid
ISA69_RS15905	COG3030	protein affecting phage T7 exclusion by the F plasmid
ISA69_RS15910	COG1027	Aspartate ammonia-lyase
ISA69_RS15915	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ISA69_RS15930	COG1309	transcriptional regulator
ISA69_RS15955	COG0457	Tetratricopeptide repeat
ISA69_RS15960	COG0726	polysaccharide deacetylase
ISA69_RS15960	COG1649	PFAM Uncharacterised BCR, COG1649
ISA69_RS15965	COG1215	transferase activity, transferring glycosyl groups
ISA69_RS15980	COG0861	Integral membrane protein TerC family
ISA69_RS16015	COG1486	melibiose metabolic process
ISA69_RS16020	COG2169	Transcriptional regulator
ISA69_RS16030	COG2824	Alkylphosphonate utilization operon protein PhnA
ISA69_RS16035	COG2764	glyoxalase bleomycin resistance protein dioxygenase
ISA69_RS16040	COG2188	Transcriptional regulator
ISA69_RS16045	COG3624	Phosphonate C-P lyase system protein PhnG
ISA69_RS16050	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
ISA69_RS16055	COG3626	phosphonate metabolism
ISA69_RS16060	COG3627	carbon phosphorus lyase activity
ISA69_RS16065	COG4107	phosphonate C-P lyase system protein PhnK
ISA69_RS16070	COG4778	phosphonate C-P lyase system protein PhnL
ISA69_RS16075	COG3454	Phosphonate metabolism
ISA69_RS16085	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ISA69_RS16095	COG4191	Histidine kinase
ISA69_RS16095	COG0784	Response regulator, receiver
ISA69_RS16100	COG1129	ABC transporter
ISA69_RS16105	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA69_RS16140	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
ISA69_RS16145	COG1301	dicarboxylic acid transport
ISA69_RS16160	COG3162	membrane
ISA69_RS16190	COG3539	Fimbrial protein
ISA69_RS16195	COG1346	cytolysis
ISA69_RS16200	COG1380	Effector of murein hydrolase LrgA
ISA69_RS16205	COG0583	DNA-binding transcription factor activity
ISA69_RS16210	COG0025	NhaP-type Na H and K H
ISA69_RS16215	COG2252	PERMEase
ISA69_RS16220	COG0625	glutathione transferase activity
ISA69_RS16225	COG0789	Transcriptional regulator
ISA69_RS16235	COG4943	cyclic-guanylate-specific phosphodiesterase activity
ISA69_RS16260	COG3842	ATPase activity
ISA69_RS16265	COG1234	tRNA 3'-trailer cleavage
ISA69_RS16270	COG1609	Transcriptional regulator
ISA69_RS16275	COG0483	inositol monophosphate 1-phosphatase activity
ISA69_RS16285	COG0583	DNA-binding transcription factor activity
ISA69_RS16295	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISA69_RS16310	COG4771	TonB-dependent receptor
ISA69_RS16315	COG0741	lytic transglycosylase activity
ISA69_RS16320	COG0629	single-stranded DNA binding
ISA69_RS16330	COG2315	Protein conserved in bacteria
ISA69_RS16335	COG0432	Pfam Uncharacterised protein family UPF0047
ISA69_RS16350	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ISA69_RS16355	COG0305	Participates in initiation and elongation during chromosome replication
ISA69_RS16370	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISA69_RS16380	COG0735	belongs to the Fur family
ISA69_RS16385	COG3237	CsbD-like
ISA69_RS16390	COG0534	Mate efflux family protein
ISA69_RS16400	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ISA69_RS16460	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ISA69_RS16470	COG0527	aspartate kinase activity
ISA69_RS16535	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ISA69_RS16565	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ISA69_RS16575	COG0456	acetyltransferase
ISA69_RS16605	COG0151	Belongs to the GarS family
ISA69_RS16615	COG4191	Histidine kinase
ISA69_RS16655	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
ISA69_RS16670	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ISA69_RS16675	COG2104	thiamine diphosphate biosynthetic process
ISA69_RS16685	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ISA69_RS16690	COG3706	GGDEF domain
ISA69_RS16700	COG1447	Phosphotransferase system cellobiose-specific component IIA
ISA69_RS16705	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ISA69_RS16740	COG0250	Participates in transcription elongation, termination and antitermination
ISA69_RS16785	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ISA69_RS16815	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ISA69_RS16825	COG1739	Uncharacterized protein family UPF0029
ISA69_RS16865	COG0805	protein transport
ISA69_RS16885	COG3165	ubiquinone biosynthetic process from chorismate
ISA69_RS16905	COG0412	Dienelactone hydrolase
ISA69_RS16915	COG0583	DNA-binding transcription factor activity
ISA69_RS16920	COG0697	spore germination
ISA69_RS16925	COG0561	phosphatase activity
ISA69_RS16930	COG2267	carboxylic ester hydrolase activity
ISA69_RS16935	COG1280	lysine exporter protein (LysE YggA)
ISA69_RS16945	COG1280	lysine exporter protein (LysE YggA)
ISA69_RS16975	COG0210	DNA helicase
ISA69_RS16980	COG1011	Hydrolase
ISA69_RS17010	COG3072	Adenylate cyclase
ISA69_RS17025	COG2959	enzyme of heme biosynthesis
ISA69_RS17030	COG3071	HemY protein
ISA69_RS17075	COG2244	polysaccharide biosynthetic process
ISA69_RS17080	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ISA69_RS17085	COG0456	acetyltransferase
ISA69_RS17090	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ISA69_RS17095	COG1088	dTDP-glucose 4,6-dehydratase activity
ISA69_RS17100	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ISA69_RS17105	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ISA69_RS17115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ISA69_RS17120	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ISA69_RS17125	COG3118	belongs to the thioredoxin family
ISA69_RS17150	COG1811	Na channel or pump
ISA69_RS17160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISA69_RS17165	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISA69_RS17175	COG0583	DNA-binding transcription factor activity
ISA69_RS17180	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ISA69_RS17190	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISA69_RS17195	COG3978	acetolactate synthase activity
ISA69_RS17215	COG3085	chromosome segregation
ISA69_RS17290	COG0583	DNA-binding transcription factor activity
ISA69_RS17305	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ISA69_RS17320	COG3443	Belongs to the bacterial solute-binding protein 9 family
ISA69_RS17325	COG2207	Transcriptional regulator
ISA69_RS17335	COG0371	Dehydrogenase
ISA69_RS17345	COG2190	(PTS) system
ISA69_RS17345	COG1263	PTS System
ISA69_RS17345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA69_RS17350	COG1609	Transcriptional regulator
ISA69_RS17355	COG0583	DNA-binding transcription factor activity
ISA69_RS17365	COG0460	homoserine dehydrogenase
ISA69_RS17365	COG0527	aspartate kinase activity
ISA69_RS17370	COG0626	cystathionine gamma-synthase activity
ISA69_RS17385	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ISA69_RS17390	COG1609	Transcriptional regulator
ISA69_RS17395	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ISA69_RS17410	COG1575	Belongs to the MenA family. Type 1 subfamily
ISA69_RS17430	COG3678	ATP-independent chaperone mediated protein folding
ISA69_RS17435	COG0745	RESPONSE REGULATOR receiver
ISA69_RS17440	COG2205	protein histidine kinase activity
ISA69_RS17445	COG2258	MOSC domain
ISA69_RS17450	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ISA69_RS17490	COG1129	ABC transporter
ISA69_RS17495	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA69_RS17500	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA69_RS17505	COG1454	alcohol dehydrogenase
ISA69_RS17515	COG2211	Major facilitator Superfamily
ISA69_RS17575	COG0205	6-phosphofructokinase activity
ISA69_RS17595	COG0437	4 iron, 4 sulfur cluster binding
ISA69_RS17600	COG2864	formate dehydrogenase
ISA69_RS17615	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ISA69_RS17625	COG0456	acetyltransferase
ISA69_RS17640	COG1011	Hydrolase
ISA69_RS17655	COG3852	Histidine kinase
ISA69_RS17670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISA69_RS17690	COG0204	Acyl-transferase
ISA69_RS17700	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ISA69_RS17705	COG3084	Protein conserved in bacteria
ISA69_RS17715	COG1763	Mo-molybdopterin cofactor biosynthetic process
ISA69_RS17740	COG2186	Transcriptional regulator
ISA69_RS17745	COG0477	Major facilitator Superfamily
ISA69_RS17750	COG1609	Transcriptional regulator
ISA69_RS17755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISA69_RS17765	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISA69_RS17770	COG1129	ABC transporter
ISA69_RS17800	COG1522	sequence-specific DNA binding
ISA69_RS17805	COG0716	FMN binding
ISA69_RS17820	COG3312	ion transport
ISA69_RS17870	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ISA69_RS17875	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ISA69_RS17880	COG0573	inorganic phosphate transmembrane transporter activity
ISA69_RS17885	COG0581	inorganic phosphate transmembrane transporter activity
ISA69_RS17890	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ISA69_RS17895	COG0704	Plays a role in the regulation of phosphate uptake
ISA69_RS17905	COG2382	esterase
ISA69_RS17910	COG0363	glucosamine-6-phosphate deaminase activity
ISA69_RS17915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISA69_RS17920	COG2252	PERMEase
ISA69_RS17925	COG0431	NADPH-dependent FMN reductase
ISA69_RS17930	COG2091	lysine biosynthetic process via aminoadipic acid
ISA69_RS17990	COG0582	viral genome integration into host DNA
ISA69_RS18005	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ISA69_RS18040	COG0561	phosphatase activity
ISA69_RS18055	COG0823	Involved in the tonB-independent uptake of proteins
ISA69_RS18060	COG5645	(Lipo)protein
ISA69_RS18080	COG2188	Transcriptional regulator
ISA69_RS18095	COG2149	membrane
ISA69_RS18105	COG0641	radical SAM
ISA69_RS18115	COG2610	gluconate transmembrane transporter activity
ISA69_RS18125	COG0583	DNA-binding transcription factor activity
ISA69_RS18130	COG2814	Major facilitator Superfamily
ISA69_RS18160	COG0028	Belongs to the TPP enzyme family
ISA69_RS18165	COG0440	acetolactate synthase activity
ISA69_RS18170	COG2197	response regulator
ISA69_RS18180	COG2271	Major facilitator Superfamily
ISA69_RS18190	COG0583	DNA-binding transcription factor activity
ISA69_RS18210	COG4580	involved in the transport of maltose and maltodextrins
ISA69_RS18215	COG1447	Phosphotransferase system cellobiose-specific component IIA
ISA69_RS18220	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA69_RS18220	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA69_RS18230	COG1609	Transcriptional regulator
ISA69_RS18240	COG3384	dioxygenase
ISA69_RS18245	COG0583	DNA-binding transcription factor activity
ISA69_RS18250	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ISA69_RS18255	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ISA69_RS18260	COG2828	Protein conserved in bacteria
ISA69_RS18275	COG0697	spore germination
ISA69_RS18280	COG1263	PTS System
ISA69_RS18280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA69_RS18290	COG2814	Major facilitator Superfamily
ISA69_RS18300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISA69_RS18335	COG0583	DNA-binding transcription factor activity
ISA69_RS18360	COG1464	Belongs to the NlpA lipoprotein family
ISA69_RS18375	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ISA69_RS18385	COG1064	alcohol dehydrogenase
ISA69_RS18440	COG2211	Major facilitator Superfamily
ISA69_RS18445	COG1501	Belongs to the glycosyl hydrolase 31 family
ISA69_RS18455	COG1486	melibiose metabolic process
ISA69_RS18460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA69_RS18460	COG1263	PTS System
ISA69_RS18465	COG2982	Protein involved in outer membrane biogenesis
ISA69_RS18470	COG2233	PERMEase
ISA69_RS18475	COG0786	glutamate:sodium symporter activity
ISA69_RS18490	COG3074	FtsZ-dependent cytokinesis
ISA69_RS18495	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ISA69_RS18520	COG3152	Membrane
ISA69_RS18530	COG1494	fructose-1,6-bisphosphatase
ISA69_RS18535	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ISA69_RS18540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISA69_RS18545	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISA69_RS18565	COG2860	membrane
ISA69_RS18575	COG2169	Transcriptional regulator
ISA69_RS18575	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ISA69_RS18585	COG1561	YicC-like family, N-terminal region
ISA69_RS18600	COG1131	(ABC) transporter
ISA69_RS18605	COG0842	Transport permease protein
ISA69_RS18635	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ISA69_RS18645	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ISA69_RS18655	COG4245	von Willebrand factor, type A
ISA69_RS18690	COG1519	Transferase
ISA69_RS18695	COG1216	Glycosyl transferase, family 2
ISA69_RS18700	COG0438	transferase activity, transferring glycosyl groups
ISA69_RS18710	COG0859	PFAM glycosyl transferase family 9
ISA69_RS18735	COG0859	PFAM glycosyl transferase family 9
ISA69_RS18750	COG0156	8-amino-7-oxononanoate synthase activity
ISA69_RS18760	COG0463	Glycosyl transferase, family 2
ISA69_RS18765	COG2861	carbohydrate metabolic process
ISA69_RS18770	COG4942	peptidase
ISA69_RS18780	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ISA69_RS18785	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ISA69_RS18805	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ISA69_RS18815	COG2186	Transcriptional regulator
ISA69_RS18835	COG3722	fumarate hydratase activity
ISA69_RS18855	COG1566	PFAM secretion protein HlyD family protein
ISA69_RS18860	COG0625	glutathione transferase activity
ISA69_RS18870	COG3276	selenocysteine insertion sequence binding
ISA69_RS18875	COG1414	Transcriptional regulator
ISA69_RS18880	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISA69_RS18885	COG3977	Valine--pyruvate aminotransferase
ISA69_RS18890	COG0366	Alpha amylase catalytic
ISA69_RS18895	COG2992	FlgJ-related protein
ISA69_RS18900	COG1609	Transcriptional regulator
ISA69_RS18900	COG2207	Transcriptional regulator
ISA69_RS18905	COG4214	carbohydrate transport
ISA69_RS18915	COG4213	ABC transporter substrate-binding protein
ISA69_RS18930	COG4682	membrane
ISA69_RS18935	COG4682	membrane
ISA69_RS18940	COG3274	enterobacterial common antigen metabolic process
ISA69_RS18965	COG0488	(ABC) transporter
ISA69_RS18970	COG1278	Cold shock
ISA69_RS18975	COG2944	sequence-specific DNA binding
ISA69_RS18980	COG2814	Major facilitator Superfamily
ISA69_RS19000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISA69_RS19010	COG1609	Transcriptional regulator
ISA69_RS19015	COG2885	chlorophyll binding
ISA69_RS19020	COG0243	molybdopterin cofactor binding
ISA69_RS19025	COG0456	acetyltransferase
ISA69_RS19030	COG2818	Glycosylase
ISA69_RS19035	COG5571	outer membrane autotransporter
ISA69_RS19040	COG2223	nitrite transmembrane transporter activity
ISA69_RS19070	COG0747	negative chemotaxis
ISA69_RS19075	COG0601	transmembrane transport
ISA69_RS19080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISA69_RS19085	COG0444	Belongs to the ABC transporter superfamily
ISA69_RS19090	COG4608	Belongs to the ABC transporter superfamily
ISA69_RS19105	COG2894	cell division
ISA69_RS19115	COG1215	transferase activity, transferring glycosyl groups
ISA69_RS19120	COG0457	Tetratricopeptide repeat
ISA69_RS19135	COG2194	sulfuric ester hydrolase activity
ISA69_RS19165	COG1215	transferase activity, transferring glycosyl groups
ISA69_RS19170	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ISA69_RS19175	COG3118	belongs to the thioredoxin family
ISA69_RS19175	COG0457	Tetratricopeptide repeat
ISA69_RS19180	COG2200	EAL domain
ISA69_RS19180	COG2199	diguanylate cyclase activity
ISA69_RS19190	COG0612	Peptidase, M16
ISA69_RS19200	COG2982	Protein involved in outer membrane biogenesis
ISA69_RS19205	COG0477	Major facilitator Superfamily
ISA69_RS19210	COG1295	ribonuclease BN
ISA69_RS19215	COG0583	DNA-binding transcription factor activity
ISA69_RS19220	COG1028	Short-chain dehydrogenase reductase Sdr
ISA69_RS19225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISA69_RS19235	COG1454	alcohol dehydrogenase
ISA69_RS19245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISA69_RS19250	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ISA69_RS19255	COG0671	phosphoesterase, PA-phosphatase related
ISA69_RS19275	COG0589	response to stress
ISA69_RS19285	COG0306	phosphate transporter
ISA69_RS19290	COG2081	HI0933 family
ISA69_RS19295	COG2239	Acts as a magnesium transporter
ISA69_RS19315	COG1124	(ABC) transporter
ISA69_RS19325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISA69_RS19330	COG0601	transmembrane transport
ISA69_RS19335	COG0747	negative chemotaxis
ISA69_RS19345	COG3479	Phenolic acid decarboxylase
ISA69_RS19385	COG0628	permease
ISA69_RS19390	COG0477	Major facilitator Superfamily
ISA69_RS19400	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ISA69_RS19415	COG3714	YhhN family
ISA69_RS19425	COG3776	membrane
ISA69_RS19430	COG0742	ribosomal rna small subunit methyltransferase
ISA69_RS19435	COG0552	protein localization to endoplasmic reticulum
ISA69_RS19440	COG2884	Cell division ATP-binding protein ftsE
ISA69_RS19445	COG2177	Part of the ABC transporter FtsEX involved in
ISA69_RS19460	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISA69_RS19470	COG0683	leucine binding
ISA69_RS19480	COG0683	leucine binding
ISA69_RS19485	COG0559	Belongs to the binding-protein-dependent transport system permease family
ISA69_RS19525	COG0584	glycerophosphoryl diester phosphodiesterase
ISA69_RS19535	COG0405	Gamma-glutamyltransferase
ISA69_RS19540	COG1247	-acetyltransferase
ISA69_RS19550	COG0673	inositol 2-dehydrogenase activity
ISA69_RS19555	COG1741	Belongs to the pirin family
ISA69_RS19560	COG1609	Transcriptional regulator
ISA69_RS19565	COG3265	gluconokinase activity
ISA69_RS19570	COG2610	gluconate transmembrane transporter activity
ISA69_RS19580	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ISA69_RS19605	COG0058	SHG alpha-glucan phosphorylase activity
ISA69_RS19620	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ISA69_RS19635	COG1349	DNA-binding transcription factor activity
ISA69_RS19645	COG0058	SHG alpha-glucan phosphorylase activity
ISA69_RS19650	COG1640	4-alpha-glucanotransferase
ISA69_RS19655	COG2610	gluconate transmembrane transporter activity
ISA69_RS19665	COG1040	competence protein
ISA69_RS19690	COG1918	ferrous iron import across plasma membrane
ISA69_RS19695	COG2183	response to ionizing radiation
ISA69_RS19700	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISA69_RS19725	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ISA69_RS19730	COG1011	Hydrolase
ISA69_RS19740	COG0494	nUDIX hydrolase
ISA69_RS19745	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ISA69_RS19770	COG4796	Type ii and iii secretion system protein
ISA69_RS19785	COG3266	domain, Protein
ISA69_RS19790	COG0338	D12 class N6 adenine-specific DNA methyltransferase
ISA69_RS19795	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ISA69_RS19820	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISA69_RS19825	COG0402	S-adenosylhomocysteine deaminase activity
ISA69_RS19830	COG0738	Major facilitator superfamily
ISA69_RS19855	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISA69_RS19860	COG1289	transmembrane transporter activity
ISA69_RS19870	COG1765	OsmC-like protein
ISA69_RS19875	COG3954	Phosphoribulokinase
ISA69_RS19885	COG0429	hydrolase of the alpha beta-hydrolase fold
ISA69_RS19890	COG0488	(ABC) transporter
ISA69_RS19905	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
ISA69_RS19910	COG1047	Peptidyl-prolyl cis-trans
ISA69_RS19920	COG0545	Peptidyl-prolyl cis-trans isomerase
ISA69_RS19925	COG2964	Protein conserved in bacteria
ISA69_RS19985	COG0051	transcription antitermination factor activity, RNA binding
ISA69_RS20010	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ISA69_RS20025	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ISA69_RS20090	COG0201	protein transport
ISA69_RS20105	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ISA69_RS20115	COG0202	RNA polymerase activity
ISA69_RS20130	COG0789	Transcriptional regulator
ISA69_RS20135	COG3036	rescue of stalled ribosome
ISA69_RS20165	COG0758	DNA mediated transformation
ISA69_RS20175	COG0551	DNA topoisomerase type I activity
ISA69_RS20195	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ISA69_RS20230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISA69_RS20235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA69_RS20240	COG1309	transcriptional regulator
ISA69_RS20260	COG4145	pantothenate transmembrane transporter activity
ISA69_RS20265	COG3924	membrane
ISA69_RS20270	COG0439	Biotin carboxylase
ISA69_RS20275	COG0511	ligase activity, forming carbon-carbon bonds
ISA69_RS20300	COG2199	diguanylate cyclase activity
ISA69_RS20300	COG2200	EAL domain
ISA69_RS20305	COG1077	Cell shape determining protein MreB Mrl
ISA69_RS20310	COG1792	Involved in formation and maintenance of cell shape
ISA69_RS20315	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ISA69_RS20325	COG1530	ribonuclease E activity
ISA69_RS20330	COG3164	Protein of unknown function
ISA69_RS20335	COG0312	modulator of DNA gyrase
ISA69_RS20340	COG0583	DNA-binding transcription factor activity
ISA69_RS20355	COG1289	transmembrane transporter activity
ISA69_RS20360	COG2732	(Barnase) inhibitor
ISA69_RS20385	COG1802	Transcriptional regulator
ISA69_RS20395	COG0471	metal ion transport
ISA69_RS20400	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ISA69_RS20405	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ISA69_RS20415	COG0511	ligase activity, forming carbon-carbon bonds
ISA69_RS20415	COG5016	pyruvate
ISA69_RS20430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISA69_RS20435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISA69_RS20440	COG3105	Protein conserved in bacteria
ISA69_RS20445	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ISA69_RS20465	COG0625	glutathione transferase activity
ISA69_RS20470	COG2969	positive regulation of protein catabolic process
ISA69_RS20480	COG0493	'glutamate synthase
ISA69_RS20485	COG0070	glutamate synthase
ISA69_RS20485	COG0067	glutamate synthase
ISA69_RS20485	COG0069	glutamate synthase activity
ISA69_RS20490	COG1242	4 iron, 4 sulfur cluster binding
ISA69_RS20495	COG2271	Major facilitator Superfamily
ISA69_RS20500	COG1063	alcohol dehydrogenase
ISA69_RS20505	COG1312	Catalyzes the dehydration of D-mannonate
ISA69_RS20510	COG2198	Histidine kinase
ISA69_RS20510	COG0784	Response regulator, receiver
ISA69_RS20510	COG5002	protein histidine kinase activity
ISA69_RS20515	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
ISA69_RS20520	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISA69_RS20525	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA69_RS20535	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA69_RS20540	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ISA69_RS20545	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ISA69_RS20550	COG1137	ATPase activity
ISA69_RS20555	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ISA69_RS20560	COG3117	lipopolysaccharide transmembrane transporter activity
ISA69_RS20565	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ISA69_RS20575	COG0530	calcium, potassium:sodium antiporter activity
ISA69_RS20580	COG1127	ABC transporter
ISA69_RS20585	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ISA69_RS20590	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISA69_RS20595	COG2854	intermembrane phospholipid transfer
ISA69_RS20600	COG3113	response to antibiotic
ISA69_RS20605	COG5007	Belongs to the BolA IbaG family
ISA69_RS20615	COG3423	Transcriptional regulator
ISA69_RS20620	COG0142	geranyltranstransferase activity
ISA69_RS20635	COG0697	spore germination
ISA69_RS20645	COG2027	D-alanyl-D-alanine carboxypeptidase
ISA69_RS20655	COG1534	Rna-binding protein
ISA69_RS20665	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ISA69_RS20670	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ISA69_RS20680	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ISA69_RS20720	COG0195	Participates in both transcription termination and antitermination
ISA69_RS20765	COG0814	amino acid
ISA69_RS20770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISA69_RS20775	COG0826	peptidase U32
ISA69_RS20780	COG0826	peptidase U32
ISA69_RS20785	COG3154	lipid carrier protein
ISA69_RS20790	COG3153	acetyltransferase
ISA69_RS20805	COG0693	protein deglycase activity
ISA69_RS20810	COG0702	epimerase
ISA69_RS20815	COG0701	Predicted permease
ISA69_RS20820	COG2823	Periplasmic or secreted lipoprotein
ISA69_RS20840	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ISA69_RS20845	COG2721	sulfolactate sulfo-lyase activity
ISA69_RS20855	COG2084	Dehydrogenase
ISA69_RS20860	COG1929	Belongs to the glycerate kinase type-1 family
ISA69_RS20885	COG1741	Belongs to the pirin family
ISA69_RS20890	COG0583	DNA-binding transcription factor activity
ISA69_RS20895	COG3152	Membrane
ISA69_RS20900	COG0435	Glutathione S-transferase
ISA69_RS20905	COG2259	Doxx family
ISA69_RS20915	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
ISA69_RS20920	COG4575	ribosome binding
ISA69_RS20925	COG1422	Protein of unknown function (DUF1090)
ISA69_RS20935	COG0586	Pfam SNARE associated Golgi protein
ISA69_RS20940	COG2186	Transcriptional regulator
ISA69_RS20945	COG2271	Major facilitator Superfamily
ISA69_RS20955	COG2721	sulfolactate sulfo-lyase activity
ISA69_RS20970	COG0861	Integral membrane protein TerC family
ISA69_RS20975	COG0673	inositol 2-dehydrogenase activity
ISA69_RS20980	COG1451	nucleotide metabolic process
ISA69_RS20985	COG3507	Belongs to the glycosyl hydrolase 43 family
ISA69_RS20995	COG2211	Major facilitator Superfamily
ISA69_RS21005	COG0446	pyridine nucleotide-disulphide oxidoreductase
ISA69_RS21005	COG1902	pentaerythritol trinitrate reductase activity
ISA69_RS21055	COG1695	Transcriptional regulator
ISA69_RS21060	COG2375	cellular response to nickel ion
ISA69_RS21075	COG1461	Dihydroxyacetone kinase
ISA69_RS21080	COG2376	Dihydroxyacetone kinase
ISA69_RS21150	COG3038	cytochrome b561
ISA69_RS21165	COG2198	Histidine kinase
ISA69_RS21165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA69_RS21165	COG2205	protein histidine kinase activity
ISA69_RS21165	COG0784	Response regulator, receiver
ISA69_RS21170	COG2197	response regulator
ISA69_RS21185	COG0426	domain, Protein
ISA69_RS21185	COG1773	rubredoxin
ISA69_RS21210	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISA69_RS21215	COG0358	DNA primase activity
ISA69_RS21220	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ISA69_RS21280	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ISA69_RS21295	COG4991	sh3 domain protein
ISA69_RS21300	COG3025	triphosphatase activity
ISA69_RS21325	COG2960	long-chain fatty acid transporting porin activity
ISA69_RS21340	COG3384	dioxygenase
ISA69_RS21345	COG0754	glutathionylspermidine amidase activity
ISA69_RS21360	COG0494	nUDIX hydrolase
ISA69_RS21365	COG3151	Protein conserved in bacteria
ISA69_RS21370	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ISA69_RS21375	COG3150	esterase
ISA69_RS21385	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ISA69_RS21390	COG2249	NAD(P)H dehydrogenase (quinone) activity
ISA69_RS21395	COG0642	Histidine kinase
ISA69_RS21405	COG3111	PFAM Bacterial OB fold (BOF) protein
ISA69_RS21410	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
ISA69_RS21415	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ISA69_RS21420	COG0204	Acyl-transferase
ISA69_RS21425	COG2132	Multicopper oxidase
ISA69_RS21430	COG1032	radical SAM domain protein
ISA69_RS21435	COG0656	L-ascorbic acid biosynthetic process
ISA69_RS21440	COG1979	alcohol dehydrogenase
ISA69_RS21445	COG2207	Transcriptional regulator
ISA69_RS21450	COG0586	Pfam SNARE associated Golgi protein
ISA69_RS21455	COG0626	cystathionine gamma-synthase activity
ISA69_RS21465	COG0848	biopolymer transport protein
ISA69_RS21485	COG0625	glutathione transferase activity
ISA69_RS21500	COG0754	glutathionylspermidine amidase activity
ISA69_RS21505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISA69_RS21535	COG0626	cystathionine gamma-synthase activity
ISA69_RS21570	COG1811	Na channel or pump
ISA69_RS21575	COG1982	Orn Lys Arg decarboxylase major
ISA69_RS21580	COG2211	Major facilitator Superfamily
ISA69_RS21595	COG1194	a g-specific adenine glycosylase
ISA69_RS21605	COG3171	Protein conserved in bacteria
ISA69_RS21620	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ISA69_RS21620	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ISA69_RS21625	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ISA69_RS21630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISA69_RS21645	COG0762	integral membrane protein
ISA69_RS21650	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ISA69_RS21655	COG2805	Type II/IV secretion system protein
ISA69_RS21675	COG0189	ligase activity
ISA69_RS21680	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ISA69_RS21685	COG2356	endonuclease I
ISA69_RS21695	COG2814	Major facilitator Superfamily
ISA69_RS21730	COG0501	Belongs to the peptidase M48B family
ISA69_RS21735	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ISA69_RS21750	COG0191	fructose-bisphosphate aldolase activity
ISA69_RS21755	COG0668	transmembrane transport
ISA69_RS21765	COG2968	Membrane
ISA69_RS21780	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISA69_RS21785	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ISA69_RS21805	COG0006	proline dipeptidase activity
ISA69_RS21810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISA69_RS21815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISA69_RS21835	COG1028	Short-chain dehydrogenase reductase Sdr
ISA69_RS21840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISA69_RS21860	COG2723	6-phospho-beta-galactosidase activity
ISA69_RS21865	COG1737	Transcriptional regulator
ISA69_RS21875	COG1272	protein, Hemolysin III
ISA69_RS21885	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ISA69_RS21895	COG0716	FMN binding
ISA69_RS21900	COG4974	Belongs to the 'phage' integrase family
ISA69_RS21910	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ISA69_RS21930	COG4942	peptidase
ISA69_RS21940	COG2814	Major facilitator Superfamily
ISA69_RS21945	COG0583	DNA-binding transcription factor activity
ISA69_RS21955	COG0667	Aldo Keto reductase
ISA69_RS21960	COG2249	NAD(P)H dehydrogenase (quinone) activity
ISA69_RS21995	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ISA69_RS22000	COG1393	Belongs to the ArsC family
ISA69_RS22015	COG1538	Outer membrane efflux protein
ISA69_RS22020	COG1289	transmembrane transporter activity
ISA69_RS22035	COG3592	Divergent 4Fe-4S mono-cluster
ISA69_RS22040	COG2388	GCN5-related N-acetyl-transferase
ISA69_RS22050	COG3539	Fimbrial protein
ISA69_RS22055	COG3539	Fimbrial protein
ISA69_RS22060	COG3539	Fimbrial protein
ISA69_RS22065	COG3188	usher protein
ISA69_RS22070	COG3121	Chaperone
ISA69_RS22075	COG3539	Fimbrial protein
ISA69_RS22085	COG4974	Belongs to the 'phage' integrase family
ISA69_RS22090	COG0582	viral genome integration into host DNA
ISA69_RS22110	COG3121	Chaperone
ISA69_RS22115	COG3188	usher protein
ISA69_RS22125	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ISA69_RS22130	COG1846	Transcriptional regulator
ISA69_RS22135	COG0697	spore germination
ISA69_RS22185	COG0667	Aldo Keto reductase
ISA69_RS22190	COG0814	amino acid
ISA69_RS22205	COG0183	Belongs to the thiolase family
ISA69_RS22215	COG0823	Involved in the tonB-independent uptake of proteins
ISA69_RS22220	COG1028	Short-chain dehydrogenase reductase Sdr
ISA69_RS22225	COG2814	Major facilitator Superfamily
ISA69_RS22260	COG3842	ATPase activity
ISA69_RS22265	COG0395	ABC-type sugar transport system, permease component
ISA69_RS22270	COG1175	transmembrane transport
ISA69_RS22275	COG1917	Cupin 2, conserved barrel domain protein
ISA69_RS22280	COG1794	racemase activity, acting on amino acids and derivatives
ISA69_RS22285	COG0583	DNA-binding transcription factor activity
ISA69_RS22295	COG1609	Transcriptional regulator
ISA69_RS22300	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA69_RS22305	COG2723	6-phospho-beta-galactosidase activity
ISA69_RS22310	COG2186	Transcriptional regulator
ISA69_RS22320	COG1609	Transcriptional regulator
ISA69_RS22340	COG0667	Aldo Keto reductase
ISA69_RS22350	COG0861	Integral membrane protein TerC family
ISA69_RS22380	COG2165	general secretion pathway protein
ISA69_RS22385	COG4795	General secretion pathway protein
ISA69_RS22395	COG4967	type IV pilus modification protein PilV
ISA69_RS22400	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ISA69_RS22405	COG1025	Belongs to the peptidase M16 family
ISA69_RS22410	COG1074	ATP-dependent DNA helicase activity
ISA69_RS22415	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ISA69_RS22425	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ISA69_RS22425	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ISA69_RS22430	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISA69_RS22435	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ISA69_RS22465	COG4656	Part of a membrane complex involved in electron transport
ISA69_RS22470	COG1454	alcohol dehydrogenase
ISA69_RS22470	COG1012	belongs to the aldehyde dehydrogenase family
ISA69_RS22500	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
ISA69_RS22665	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ISA69_RS22670	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ISA69_RS22675	COG2166	iron-sulfur cluster assembly
ISA69_RS22680	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ISA69_RS22690	COG0583	DNA-binding transcription factor activity
ISA69_RS22695	COG2363	Small membrane protein
ISA69_RS22705	COG1349	DNA-binding transcription factor activity
ISA69_RS22725	COG0738	Major facilitator superfamily
ISA69_RS22730	COG0235	Class ii aldolase
ISA69_RS22735	COG1454	alcohol dehydrogenase
ISA69_RS22755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISA69_RS22770	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ISA69_RS22775	COG2011	ABC-type metal ion transport system permease component
ISA69_RS22780	COG1464	Belongs to the NlpA lipoprotein family
ISA69_RS22785	COG0477	Major facilitator Superfamily
ISA69_RS22795	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISA69_RS22800	COG1760	l-serine dehydratase
ISA69_RS22805	COG0814	amino acid
ISA69_RS22810	COG1611	Belongs to the LOG family
ISA69_RS22825	COG3098	single-species biofilm formation
ISA69_RS22830	COG0564	pseudouridine synthase activity
ISA69_RS22835	COG0716	FMN binding
ISA69_RS22840	COG2271	Major facilitator Superfamily
ISA69_RS22845	COG4948	Mandelate Racemase Muconate Lactonizing
ISA69_RS22850	COG4948	Mandelate Racemase Muconate Lactonizing
ISA69_RS22855	COG1929	Belongs to the glycerate kinase type-1 family
ISA69_RS22860	COG3437	response regulator, receiver
ISA69_RS22860	COG4999	Histidine kinase
ISA69_RS22860	COG2205	protein histidine kinase activity
ISA69_RS22860	COG3850	Histidine kinase
ISA69_RS22870	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISA69_RS22875	COG3956	TIGRFAM MazG family protein
ISA69_RS22895	COG0602	queuosine metabolic process
ISA69_RS22900	COG0720	synthase
ISA69_RS22920	COG2234	aminopeptidase activity
ISA69_RS22980	COG4942	peptidase
ISA69_RS22980	COG1388	LysM domain
ISA69_RS22985	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISA69_RS23010	COG0163	prenyltransferase activity
ISA69_RS23015	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ISA69_RS23055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISA69_RS23060	COG4558	Periplasmic binding protein
ISA69_RS23065	COG3720	iron ion transport
ISA69_RS23085	COG0679	Auxin Efflux Carrier
ISA69_RS23100	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISA69_RS23105	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISA69_RS23110	COG1121	(ABC) transporter
ISA69_RS23115	COG0803	Belongs to the bacterial solute-binding protein 9 family
ISA69_RS23120	COG1609	Transcriptional regulator
ISA69_RS23125	COG1940	carbohydrate kinase activity
ISA69_RS23130	COG1447	Phosphotransferase system cellobiose-specific component IIA
ISA69_RS23135	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA69_RS23140	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA69_RS23145	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA69_RS23150	COG4580	involved in the transport of maltose and maltodextrins
ISA69_RS23160	COG2723	6-phospho-beta-galactosidase activity
ISA69_RS23170	COG0309	Hydrogenase expression formation protein (HypE)
ISA69_RS23175	COG0409	Hydrogenase expression formation protein
ISA69_RS23180	COG0298	carbon dioxide binding
ISA69_RS23185	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ISA69_RS23200	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISA69_RS23205	COG0651	ATP synthesis coupled electron transport
ISA69_RS23210	COG0650	Formate hydrogenlyase subunit 4
ISA69_RS23215	COG3261	NADH dehydrogenase
ISA69_RS23215	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
ISA69_RS23220	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISA69_RS23225	COG3260	NADH ubiquinone oxidoreductase 20
ISA69_RS23235	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ISA69_RS23245	COG2723	6-phospho-beta-galactosidase activity
ISA69_RS23250	COG1263	PTS System
ISA69_RS23250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISA69_RS23255	COG1609	Transcriptional regulator
ISA69_RS23260	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISA69_RS23265	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ISA69_RS23270	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ISA69_RS23295	COG1349	DNA-binding transcription factor activity
ISA69_RS23300	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA69_RS23305	COG1028	Short-chain dehydrogenase reductase Sdr
ISA69_RS23315	COG3732	PTS system glucitol sorbitol-specific
ISA69_RS23320	COG3730	PTS system glucitol sorbitol-specific
ISA69_RS23325	COG2951	lytic endotransglycosylase activity
ISA69_RS23330	COG1121	(ABC) transporter
ISA69_RS23335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISA69_RS23340	COG0803	Belongs to the bacterial solute-binding protein 9 family
ISA69_RS23345	COG1546	Belongs to the CinA family
ISA69_RS23365	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ISA69_RS23395	COG2823	Periplasmic or secreted lipoprotein
ISA69_RS23400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISA69_RS23405	COG1238	metal cluster binding
ISA69_RS23425	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ISA69_RS23430	COG2814	Major facilitator Superfamily
ISA69_RS23435	COG1566	PFAM secretion protein HlyD family protein
ISA69_RS23440	COG1846	Transcriptional regulator
ISA69_RS23450	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ISA69_RS23460	COG4176	ABC-type proline glycine betaine transport system permease component
ISA69_RS23475	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISA69_RS23485	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ISA69_RS23490	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISA69_RS23500	COG4575	ribosome binding
ISA69_RS23530	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ISA69_RS23535	COG0640	Transcriptional regulator
ISA69_RS23545	COG0583	DNA-binding transcription factor activity
ISA69_RS23550	COG0671	phosphoesterase, PA-phosphatase related
ISA69_RS23555	COG3284	Transcriptional regulator
ISA69_RS23565	COG3539	Fimbrial protein
ISA69_RS23570	COG3121	Chaperone
ISA69_RS23605	COG1028	Short-chain dehydrogenase reductase Sdr
ISA69_RS23615	COG0235	Class ii aldolase
ISA69_RS23620	COG1126	abc transporter atp-binding protein
ISA69_RS23625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISA69_RS23655	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISA69_RS23705	COG0431	NADPH-dependent FMN reductase
ISA69_RS23720	COG2271	Major facilitator Superfamily
ISA69_RS23725	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
ISA69_RS23730	COG0477	Major facilitator Superfamily
ISA69_RS23735	COG3622	Belongs to the hyi family
ISA69_RS23760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISA69_RS23765	COG3708	Transcriptional regulator
ISA69_RS23765	COG2207	Transcriptional regulator
ISA69_RS23790	COG4974	Belongs to the 'phage' integrase family
ISA69_RS23825	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ISA69_RS23870	COG4695	Portal protein
ISA69_RS24030	COG2867	negative regulation of translational initiation
ISA69_RS24045	COG0497	DNA recombination
ISA69_RS24060	COG4536	flavin adenine dinucleotide binding
ISA69_RS24065	COG4137	Cytochrome C assembly protein
ISA69_RS24070	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ISA69_RS24105	COG2885	chlorophyll binding
ISA69_RS24110	COG2199	diguanylate cyclase activity
ISA69_RS24120	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISA69_RS24125	COG1605	Chorismate mutase
ISA69_RS24125	COG0287	Prephenate dehydrogenase
ISA69_RS24135	COG1605	Chorismate mutase
ISA69_RS24135	COG0077	Prephenate dehydratase
ISA69_RS24145	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ISA69_RS24150	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISA69_RS24165	COG0542	response to heat
ISA69_RS24190	COG0477	Major facilitator Superfamily
ISA69_RS24195	COG5544	Lipoprotein
ISA69_RS24200	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISA69_RS24210	COG3148	PFAM DTW domain containing protein
ISA69_RS24215	COG3118	belongs to the thioredoxin family
ISA69_RS24220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISA69_RS24235	COG0513	Belongs to the DEAD box helicase family
ISA69_RS24245	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ISA69_RS24260	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
ISA69_RS24265	COG3026	antisigma factor binding
ISA69_RS24270	COG3086	response to oxidative stress
ISA69_RS24280	COG0681	Belongs to the peptidase S26 family
ISA69_RS24300	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ISA69_RS24310	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISA69_RS24315	COG1737	Transcriptional regulator
ISA69_RS24320	COG0560	Phosphoserine phosphatase
ISA69_RS24335	COG0047	phosphoribosylformylglycinamidine synthase activity
ISA69_RS24335	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ISA69_RS24340	COG2205	protein histidine kinase activity
ISA69_RS24345	COG3170	Tfp pilus assembly protein FimV
ISA69_RS24350	COG2204	response regulator
ISA69_RS24355	COG0347	Belongs to the P(II) protein family
ISA69_RS24360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISA69_RS24360	COG1017	nitric oxide dioxygenase activity
ISA69_RS24370	COG2259	Doxx family
ISA69_RS24375	COG2814	Major facilitator Superfamily
ISA69_RS24380	COG3711	transcriptional antiterminator
ISA69_RS24385	COG3683	transport system, periplasmic component
ISA69_RS24390	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ISA69_RS24420	COG0822	iron-sulfur transferase activity
ISA69_RS24440	COG0633	Ferredoxin
ISA69_RS24445	COG2975	iron-sulfur cluster assembly
ISA69_RS24465	COG2897	thiosulfate sulfurtransferase activity
ISA69_RS24470	COG2373	Large extracellular alpha-helical protein
ISA69_RS24475	COG4953	penicillin-binding protein 1C
ISA69_RS24505	COG2976	Protein conserved in bacteria
ISA69_RS24525	COG1645	bacterial-type flagellum-dependent swarming motility
ISA69_RS24535	COG0516	GMP reductase activity
ISA69_RS24535	COG0517	IMP dehydrogenase activity
ISA69_RS24560	COG2200	EAL domain
ISA69_RS24575	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ISA69_RS24590	COG2723	6-phospho-beta-galactosidase activity
ISA69_RS24600	COG2233	PERMEase
ISA69_RS24615	COG1393	Belongs to the ArsC family
ISA69_RS24620	COG4783	chaperone-mediated protein folding
ISA69_RS24630	COG0628	permease
ISA69_RS24635	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ISA69_RS24640	COG2716	regulation of RNA biosynthetic process
ISA69_RS24650	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ISA69_RS24660	COG2321	neutral zinc metallopeptidase
ISA69_RS24665	COG1444	tRNA N-acetyltransferase activity
ISA69_RS24670	COG0400	carboxylic ester hydrolase activity
ISA69_RS24685	COG1393	Belongs to the ArsC family
ISA69_RS24695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISA69_RS24700	COG0493	'glutamate synthase
ISA69_RS24700	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISA69_RS24710	COG5342	invasion associated locus B
ISA69_RS24715	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ISA69_RS24720	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISA69_RS24730	COG4810	utilization protein
ISA69_RS24760	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
ISA69_RS24820	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISA69_RS24840	COG2837	iron assimilation
ISA69_RS24845	COG2852	Protein conserved in bacteria
ISA69_RS24850	COG4150	thiosulfate binding
ISA69_RS24855	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ISA69_RS24860	COG4208	sulfate ABC transporter
ISA69_RS24865	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ISA69_RS24875	COG4319	ketosteroid isomerase
ISA69_RS24910	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ISA69_RS24930	COG3530	Putative quorum-sensing-regulated virulence factor
ISA69_RS24935	COG0385	Bile acid
ISA69_RS24940	COG0583	DNA-binding transcription factor activity
ISA69_RS24970	COG3415	Transposase
ISA69_RS24975	COG3415	Transposase
ISA69_RS24990	COG2200	EAL domain
ISA69_RS24990	COG2199	diguanylate cyclase activity
ISA69_RS24995	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISA69_RS25010	COG0667	Aldo Keto reductase
ISA69_RS25015	COG3961	Belongs to the TPP enzyme family
ISA69_RS25030	COG3279	Response regulator of the LytR AlgR family
ISA69_RS25035	COG3275	phosphorelay sensor kinase activity
ISA69_RS25050	COG0436	Aminotransferase
ISA69_RS25060	COG2807	transmembrane transport
ISA69_RS25065	COG0590	tRNA wobble adenosine to inosine editing
ISA69_RS25070	COG0583	DNA-binding transcription factor activity
ISA69_RS25105	COG2885	chlorophyll binding
ISA69_RS25250	COG0582	viral genome integration into host DNA
ISA69_RS25330	COG1061	Type III restriction enzyme res subunit
ISA69_RS25415	COG0740	serine-type endopeptidase activity
ISA69_RS25455	COG1196	nuclear chromosome segregation
ISA69_RS25520	COG2116	formate transmembrane transporter activity
ISA69_RS25525	COG2853	Lipoprotein
ISA69_RS25535	COG3691	Protein conserved in bacteria
ISA69_RS25550	COG2062	phosphohistidine phosphatase, SixA
ISA69_RS25575	COG0730	response to heat
ISA69_RS25580	COG3101	peptidyl-lysine hydroxylation
ISA69_RS25595	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISA69_RS25605	COG2188	Transcriptional regulator
ISA69_RS25615	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISA69_RS25620	COG1447	Phosphotransferase system cellobiose-specific component IIA
ISA69_RS25640	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ISA69_RS25650	COG0586	Pfam SNARE associated Golgi protein
ISA69_RS25660	COG0285	dihydrofolate synthase activity
ISA69_RS25665	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ISA69_RS25670	COG1286	toxin biosynthetic process
ISA69_RS25675	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ISA69_RS25680	COG0163	prenyltransferase activity
ISA69_RS25705	COG4160	amino acid transport
ISA69_RS25710	COG4598	ABC transporter
ISA69_RS25725	COG1090	epimerase
ISA69_RS25730	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ISA69_RS25735	COG0625	glutathione transferase activity
ISA69_RS25740	COG0625	glutathione transferase activity
ISA69_RS25745	COG0622	Phosphoesterase
ISA69_RS25750	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ISA69_RS25775	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISA69_RS25780	COG0490	domain, Protein
ISA69_RS25780	COG0471	metal ion transport
ISA69_RS25790	COG0436	Aminotransferase
ISA69_RS25795	COG0583	DNA-binding transcription factor activity
ISA69_RS25840	COG0839	Belongs to the complex I subunit 6 family
ISA69_RS25850	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ISA69_RS25855	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISA69_RS25870	COG2153	protein acetylation
ISA69_RS25875	COG1169	isochorismate synthase
ISA69_RS25900	COG0318	PFAM AMP-dependent synthetase and ligase
ISA69_RS25910	COG5464	transposase or invertase
ISA69_RS25925	COG1414	Transcriptional regulator
ISA69_RS25935	COG2271	Major facilitator Superfamily
ISA69_RS25945	COG0247	lactate metabolic process
ISA69_RS25955	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ISA69_RS25960	COG2271	Major facilitator Superfamily
ISA69_RS25965	COG0584	glycerophosphoryl diester phosphodiesterase
ISA69_RS25970	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISA69_RS26005	COG0642	Histidine kinase
ISA69_RS26005	COG2198	Histidine kinase
ISA69_RS26020	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ISA69_RS26020	COG2169	Transcriptional regulator
ISA69_RS26025	COG3145	DNA-N1-methyladenine dioxygenase activity
ISA69_RS26030	COG4615	Cyclic peptide transporter
ISA69_RS26035	COG2239	Acts as a magnesium transporter
ISA69_RS26040	COG0659	secondary active sulfate transmembrane transporter activity
ISA69_RS26055	COG0628	permease
ISA69_RS26070	COG1126	abc transporter atp-binding protein
ISA69_RS26075	COG0765	amino acid transport
ISA69_RS26080	COG0765	amino acid transport
ISA69_RS26095	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ISA69_RS26120	COG1349	DNA-binding transcription factor activity
ISA69_RS26125	COG0494	nUDIX hydrolase
ISA69_RS26145	COG1061	Type III restriction enzyme res subunit
ISA69_RS26150	COG1187	pseudouridine synthase activity
ISA69_RS26155	COG2814	Major facilitator Superfamily
ISA69_RS26165	COG4172	Belongs to the ABC transporter superfamily
ISA69_RS26170	COG4239	(ABC) transporter, permease
ISA69_RS26175	COG4174	ABC transporter (Permease)
ISA69_RS26180	COG4166	transmembrane transport
ISA69_RS26185	COG2200	EAL domain
ISA69_RS26190	COG0791	NLP P60 protein
ISA69_RS26195	COG0671	phosphoesterase, PA-phosphatase related
ISA69_RS26200	COG0523	cobalamin synthesis protein
ISA69_RS26205	COG0246	Mannitol dehydrogenase
ISA69_RS26210	COG1312	Catalyzes the dehydration of D-mannonate
ISA69_RS26235	COG1566	PFAM secretion protein HlyD family protein
ISA69_RS26240	COG2814	Major facilitator Superfamily
ISA69_RS26245	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA69_RS26245	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISA69_RS26250	COG1105	Belongs to the carbohydrate kinase PfkB family
ISA69_RS26255	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ISA69_RS26255	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISA69_RS26255	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISA69_RS26265	COG2855	membrane
ISA69_RS26270	COG0583	DNA-binding transcription factor activity
ISA69_RS26275	COG0833	amino acid
ISA69_RS26280	COG4771	TonB-dependent receptor
ISA69_RS26295	COG2311	Membrane
ISA69_RS26310	COG1129	ABC transporter
ISA69_RS26330	COG2949	membrane
ISA69_RS26340	COG1346	cytolysis
ISA69_RS26350	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISA69_RS26370	COG2723	6-phospho-beta-galactosidase activity
ISA69_RS26375	COG1538	Outer membrane efflux protein
ISA69_RS26380	COG0586	Pfam SNARE associated Golgi protein
ISA69_RS26390	COG1686	Belongs to the peptidase S11 family
ISA69_RS26400	COG0277	FAD linked oxidase domain protein
ISA69_RS26405	COG1472	Belongs to the glycosyl hydrolase 3 family
ISA69_RS26410	COG1732	Glycine betaine
ISA69_RS26415	COG1174	glycine betaine transport