locus-tag	class	description
AS188_RS00010	COG4638	Rieske (2fe-2S)
AS188_RS00025	COG1028	Short-chain dehydrogenase reductase Sdr
AS188_RS00035	COG4829	muconolactone delta-isomerase
AS188_RS00045	COG0583	DNA-binding transcription factor activity
AS188_RS00050	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AS188_RS00055	COG0318	PFAM AMP-dependent synthetase and ligase
AS188_RS00065	COG2197	response regulator
AS188_RS00085	COG0436	Aminotransferase
AS188_RS00090	COG0508	dehydrogenase complex catalyzes the overall conversion of
AS188_RS00095	COG0022	dehydrogenase e1 component
AS188_RS00105	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AS188_RS00110	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AS188_RS00130	COG0446	pyridine nucleotide-disulphide oxidoreductase
AS188_RS00150	COG0469	pyruvate kinase activity
AS188_RS00150	COG0469	pyruvate kinase activity
AS188_RS00160	COG2814	Major facilitator Superfamily
AS188_RS00180	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AS188_RS00190	COG1254	Belongs to the acylphosphatase family
AS188_RS00240	COG1131	(ABC) transporter
AS188_RS00245	COG3559	Exporter of polyketide antibiotics
AS188_RS00250	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AS188_RS00255	COG0693	protein deglycase activity
AS188_RS00270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS188_RS00270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AS188_RS00275	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
AS188_RS00295	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AS188_RS00305	COG1253	flavin adenine dinucleotide binding
AS188_RS00310	COG0584	glycerophosphoryl diester phosphodiesterase
AS188_RS00320	COG1482	cell wall glycoprotein biosynthetic process
AS188_RS00330	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AS188_RS00330	COG1017	nitric oxide dioxygenase activity
AS188_RS00335	COG1959	2 iron, 2 sulfur cluster binding
AS188_RS00340	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AS188_RS00350	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AS188_RS00350	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AS188_RS00355	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AS188_RS00360	COG0509	glycine decarboxylation via glycine cleavage system
AS188_RS00365	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AS188_RS00375	COG0667	Aldo Keto reductase
AS188_RS00380	COG2062	phosphohistidine phosphatase, SixA
AS188_RS00385	COG0745	RESPONSE REGULATOR receiver
AS188_RS00390	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AS188_RS00405	COG4974	Belongs to the 'phage' integrase family
AS188_RS00470	COG0277	FAD linked oxidase domain protein
AS188_RS00470	COG0247	lactate metabolic process
AS188_RS00480	COG1201	RNA secondary structure unwinding
AS188_RS00485	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AS188_RS00495	COG0477	Major facilitator Superfamily
AS188_RS00505	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AS188_RS00515	COG0590	tRNA wobble adenosine to inosine editing
AS188_RS00520	COG2233	PERMEase
AS188_RS00530	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AS188_RS00540	COG1012	belongs to the aldehyde dehydrogenase family
AS188_RS00550	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AS188_RS00555	COG0564	pseudouridine synthase activity
AS188_RS00580	COG0343	queuine tRNA-ribosyltransferase activity
AS188_RS00610	COG0351	phosphomethylpyrimidine kinase
AS188_RS00615	COG1309	transcriptional regulator
AS188_RS00635	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AS188_RS00665	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AS188_RS00670	COG0047	phosphoribosylformylglycinamidine synthase activity
AS188_RS00675	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AS188_RS00685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AS188_RS00725	COG1832	CoA-binding protein
AS188_RS00750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AS188_RS00755	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AS188_RS00765	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AS188_RS00775	COG1832	CoA-binding protein
AS188_RS00780	COG1115	amino acid carrier protein
AS188_RS00785	COG0129	dihydroxy-acid dehydratase activity
AS188_RS00800	COG0183	Belongs to the thiolase family
AS188_RS00810	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AS188_RS00820	COG1028	Short-chain dehydrogenase reductase Sdr
AS188_RS00830	COG0477	Major facilitator Superfamily
AS188_RS00835	COG1522	sequence-specific DNA binding
AS188_RS00840	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AS188_RS00845	COG0028	Belongs to the TPP enzyme family
AS188_RS00880	COG0477	Major facilitator Superfamily
AS188_RS00890	COG1414	Transcriptional regulator
AS188_RS00900	COG3971	2-oxopent-4-enoate hydratase activity
AS188_RS00950	COG0673	inositol 2-dehydrogenase activity
AS188_RS00970	COG0830	nickel cation binding
AS188_RS00980	COG0804	urea catabolic process
AS188_RS00985	COG0832	Belongs to the urease beta subunit family
AS188_RS00990	COG0831	urea catabolic process
AS188_RS00995	COG0310	cobalt ion transport
AS188_RS01005	COG0180	Tryptophanyl-tRNA synthetase
AS188_RS01030	COG1253	flavin adenine dinucleotide binding
AS188_RS01080	COG0039	L-malate dehydrogenase activity
AS188_RS01085	COG1620	l-lactate permease
AS188_RS01100	COG1053	succinate dehydrogenase
AS188_RS01110	COG0471	metal ion transport
AS188_RS01145	COG0183	Belongs to the thiolase family
AS188_RS01150	COG1024	Enoyl-CoA hydratase
AS188_RS01165	COG2050	protein possibly involved in aromatic compounds catabolism
AS188_RS01170	COG1012	belongs to the aldehyde dehydrogenase family
AS188_RS01170	COG2030	dehydratase
AS188_RS01190	COG3396	Phenylacetate-CoA oxygenase
AS188_RS01195	COG3460	Phenylacetate-CoA oxygenase
AS188_RS01200	COG3396	Phenylacetate-CoA oxygenase
AS188_RS01205	COG2151	metal-sulfur cluster biosynthetic enzyme
AS188_RS01210	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AS188_RS01220	COG3590	peptidase
AS188_RS01230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AS188_RS01245	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AS188_RS01250	COG1113	amino acid transport
AS188_RS01265	COG0673	inositol 2-dehydrogenase activity
AS188_RS01270	COG0686	Belongs to the AlaDH PNT family
AS188_RS01275	COG0006	proline dipeptidase activity
AS188_RS01280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS188_RS01285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AS188_RS01290	COG0477	Major facilitator Superfamily
AS188_RS01310	COG0247	lactate metabolic process
AS188_RS01310	COG0277	FAD linked oxidase domain protein
AS188_RS01315	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AS188_RS01345	COG0191	fructose-bisphosphate aldolase activity
AS188_RS01355	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AS188_RS01380	COG0514	ATP-dependent DNA helicase (RecQ)
AS188_RS01400	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AS188_RS01435	COG1131	(ABC) transporter
AS188_RS01455	COG0366	Alpha amylase catalytic
AS188_RS01505	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AS188_RS01525	COG0175	sulfate reduction
AS188_RS01530	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AS188_RS01540	COG2252	PERMEase
AS188_RS01545	COG3012	SEC-C Motif Domain Protein
AS188_RS01560	COG0814	amino acid
AS188_RS01590	COG1937	Protein conserved in bacteria
AS188_RS01600	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AS188_RS01610	COG1741	Belongs to the pirin family
AS188_RS01615	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AS188_RS01625	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AS188_RS01645	COG0405	Gamma-glutamyltransferase
AS188_RS01650	COG1012	belongs to the aldehyde dehydrogenase family
AS188_RS01665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS188_RS01700	COG0277	FAD linked oxidase domain protein
AS188_RS01715	COG3387	PFAM Glycoside hydrolase 15-related
AS188_RS01720	COG1937	Protein conserved in bacteria
AS188_RS01750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS188_RS01755	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AS188_RS01760	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AS188_RS01785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS188_RS01805	COG1012	belongs to the aldehyde dehydrogenase family
AS188_RS01810	COG0425	Belongs to the sulfur carrier protein TusA family
AS188_RS01815	COG2391	methyltransferase activity
AS188_RS01840	COG3237	CsbD-like
AS188_RS01865	COG0477	Major facilitator Superfamily
AS188_RS01875	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AS188_RS01880	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AS188_RS01880	COG1082	Xylose isomerase domain protein TIM barrel
AS188_RS01915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AS188_RS01920	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AS188_RS01940	COG2514	catechol 2,3-dioxygenase activity
AS188_RS01955	COG2022	thiamine diphosphate biosynthetic process
AS188_RS01965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AS188_RS01965	COG2022	thiamine diphosphate biosynthetic process
AS188_RS01970	COG0352	thiamine-phosphate diphosphorylase activity
AS188_RS01985	COG1695	Transcriptional regulator
AS188_RS01995	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AS188_RS02000	COG0667	Aldo Keto reductase
AS188_RS02005	COG2814	Major facilitator Superfamily
AS188_RS02010	COG1940	carbohydrate kinase activity
AS188_RS02015	COG1522	sequence-specific DNA binding
AS188_RS02025	COG0366	Alpha amylase catalytic
AS188_RS02035	COG3384	dioxygenase
AS188_RS02045	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AS188_RS02055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AS188_RS02085	COG2364	Membrane
AS188_RS02095	COG1063	alcohol dehydrogenase
AS188_RS02105	COG1522	sequence-specific DNA binding
AS188_RS02110	COG0686	Belongs to the AlaDH PNT family
AS188_RS02115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AS188_RS02135	COG1522	sequence-specific DNA binding
AS188_RS02155	COG1012	belongs to the aldehyde dehydrogenase family
AS188_RS02160	COG0833	amino acid
AS188_RS02185	COG1131	(ABC) transporter
AS188_RS02195	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AS188_RS02200	COG0667	Aldo Keto reductase
AS188_RS02255	COG0583	DNA-binding transcription factor activity
AS188_RS02270	COG0824	Thioesterase
AS188_RS02280	COG1250	3-hydroxyacyl-CoA dehydrogenase
AS188_RS02285	COG1024	Enoyl-CoA hydratase
AS188_RS02310	COG2814	Major facilitator Superfamily
AS188_RS02340	COG0589	response to stress
AS188_RS02360	COG3290	protein histidine kinase activity
AS188_RS02365	COG4565	transcriptional regulatory protein
AS188_RS02375	COG1595	DNA-templated transcription, initiation
AS188_RS02380	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AS188_RS02385	COG0367	asparagine synthase
AS188_RS02390	COG2409	Drug exporters of the RND superfamily
AS188_RS02420	COG3387	PFAM Glycoside hydrolase 15-related
AS188_RS02430	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AS188_RS02470	COG1403	HNH endonuclease
AS188_RS02475	COG1902	pentaerythritol trinitrate reductase activity
AS188_RS02500	COG3540	Alkaline phosphatase
AS188_RS02520	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AS188_RS02535	COG1104	cysteine desulfurase activity
AS188_RS02545	COG0477	Major facilitator Superfamily
AS188_RS02565	COG1028	Short-chain dehydrogenase reductase Sdr
AS188_RS02620	COG1174	glycine betaine transport
AS188_RS02625	COG1125	glycine betaine transport
AS188_RS02625	COG0517	IMP dehydrogenase activity
AS188_RS02650	COG2318	DinB family
AS188_RS02660	COG1132	(ABC) transporter
AS188_RS02665	COG2259	Doxx family
AS188_RS02670	COG1846	Transcriptional regulator
AS188_RS02680	COG2258	MOSC domain
AS188_RS02690	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AS188_RS02695	COG0656	L-ascorbic acid biosynthetic process
AS188_RS02700	COG3104	oligopeptide transport
AS188_RS02715	COG0531	amino acid
AS188_RS02720	COG0589	response to stress
AS188_RS02735	COG0671	phosphoesterase, PA-phosphatase related
AS188_RS02750	COG0798	PFAM Bile acid sodium symporter
AS188_RS02755	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AS188_RS02765	COG1940	carbohydrate kinase activity
AS188_RS02770	COG0477	Major facilitator Superfamily
AS188_RS02775	COG0028	Belongs to the TPP enzyme family
AS188_RS02785	COG1063	alcohol dehydrogenase
AS188_RS02790	COG2205	protein histidine kinase activity
AS188_RS02795	COG0745	RESPONSE REGULATOR receiver
AS188_RS02800	COG0705	Rhomboid family
AS188_RS02800	COG0457	Tetratricopeptide repeat
AS188_RS02815	COG1914	H( )-stimulated, divalent metal cation uptake system
AS188_RS02835	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AS188_RS02840	COG0187	DNA topoisomerase II activity
AS188_RS02845	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
AS188_RS02850	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AS188_RS02855	COG0592	DNA-directed DNA polymerase activity
AS188_RS02860	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AS188_RS02865	COG0594	ribonuclease P activity
AS188_RS02870	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AS188_RS02875	COG0706	membrane insertase activity
AS188_RS02885	COG0357	Ribosomal RNA small subunit methyltransferase G
AS188_RS02890	COG1192	Involved in chromosome partitioning
AS188_RS02900	COG3409	Peptidoglycan-binding domain 1 protein
AS188_RS02900	COG0860	N-Acetylmuramoyl-L-alanine amidase
AS188_RS02905	COG3118	belongs to the thioredoxin family
AS188_RS02910	COG0492	ferredoxin-NADP+ reductase activity
AS188_RS02930	COG0617	tRNA 3'-terminal CCA addition
AS188_RS02960	COG0318	PFAM AMP-dependent synthetase and ligase
AS188_RS02965	COG3842	ATPase activity
AS188_RS02970	COG4208	sulfate ABC transporter
AS188_RS02990	COG0360	Binds together with S18 to 16S ribosomal RNA
AS188_RS03000	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AS188_RS03005	COG0359	binds to the 23S rRNA
AS188_RS03010	COG2890	protein-(glutamine-N5) methyltransferase activity
AS188_RS03035	COG0305	Participates in initiation and elongation during chromosome replication
AS188_RS03035	COG0305	Participates in initiation and elongation during chromosome replication
AS188_RS03075	COG0446	pyridine nucleotide-disulphide oxidoreductase
AS188_RS03080	COG0789	Transcriptional regulator
AS188_RS03100	COG3328	transposase activity
AS188_RS03105	COG1484	DNA-dependent DNA replication
AS188_RS03125	COG0330	HflC and HflK could
AS188_RS03145	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AS188_RS03165	COG1063	alcohol dehydrogenase
AS188_RS03190	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
AS188_RS03195	COG1140	nitrate reductase beta subunit
AS188_RS03245	COG0822	iron-sulfur transferase activity
AS188_RS03250	COG4974	Belongs to the 'phage' integrase family
AS188_RS03265	COG1295	ribonuclease BN
AS188_RS03270	COG4941	Belongs to the sigma-70 factor family
AS188_RS03280	COG2354	Protein conserved in bacteria
AS188_RS03295	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
AS188_RS03315	COG2814	Major facilitator Superfamily
AS188_RS03330	COG2132	Multicopper oxidase
AS188_RS03345	COG2217	Heavy metal translocating P-type atpase
AS188_RS03350	COG2205	protein histidine kinase activity
AS188_RS03355	COG0745	RESPONSE REGULATOR receiver
AS188_RS03375	COG2860	membrane
AS188_RS03385	COG2807	transmembrane transport
AS188_RS03395	COG1113	amino acid transport
AS188_RS03410	COG2610	gluconate transmembrane transporter activity
AS188_RS03415	COG1028	Short-chain dehydrogenase reductase Sdr
AS188_RS03420	COG1063	alcohol dehydrogenase
AS188_RS03425	COG1070	Carbohydrate kinase
AS188_RS03445	COG0252	asparaginase activity
AS188_RS03465	COG2208	phosphoserine phosphatase activity
AS188_RS03470	COG2814	Major facilitator Superfamily
AS188_RS03505	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AS188_RS03530	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AS188_RS03555	COG1760	l-serine dehydratase
AS188_RS03580	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AS188_RS03590	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AS188_RS03625	COG1121	(ABC) transporter
AS188_RS03630	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AS188_RS03640	COG0657	acetylesterase activity
AS188_RS03660	COG1953	Uracil, thiamine, allantoin
AS188_RS03695	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AS188_RS03700	COG1012	belongs to the aldehyde dehydrogenase family
AS188_RS03710	COG0412	Dienelactone hydrolase
AS188_RS03715	COG0579	oxidoreductase
AS188_RS03735	COG0523	cobalamin synthesis protein
AS188_RS03740	COG1228	amidohydrolase
AS188_RS03775	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AS188_RS03780	COG2197	response regulator
AS188_RS03785	COG4585	Histidine kinase
AS188_RS03845	COG3547	Transposase (IS116 IS110 IS902 family)
AS188_RS03860	COG0318	PFAM AMP-dependent synthetase and ligase
AS188_RS03865	COG0318	PFAM AMP-dependent synthetase and ligase
AS188_RS03875	COG1401	restriction endodeoxyribonuclease activity
AS188_RS03905	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AS188_RS03910	COG3328	transposase activity
AS188_RS03930	COG3328	transposase activity
AS188_RS03945	COG0583	DNA-binding transcription factor activity
AS188_RS03950	COG0515	serine threonine protein kinase
AS188_RS03950	COG2815	serine threonine protein kinase
AS188_RS03975	COG1201	RNA secondary structure unwinding
AS188_RS03990	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AS188_RS04040	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AS188_RS04090	COG3629	intracellular signal transduction
AS188_RS04090	COG3903	Transcriptional regulator
AS188_RS04115	COG1802	Transcriptional regulator
AS188_RS04120	COG1914	H( )-stimulated, divalent metal cation uptake system
AS188_RS04125	COG1402	creatininase
AS188_RS04165	COG2233	PERMEase
AS188_RS04200	COG0154	amidase activity
AS188_RS04205	COG1984	allophanate hydrolase subunit 2
AS188_RS04210	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AS188_RS04225	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AS188_RS04240	COG2814	Major facilitator Superfamily
AS188_RS04245	COG1309	transcriptional regulator
AS188_RS04280	COG0183	Belongs to the thiolase family
AS188_RS04285	COG0318	PFAM AMP-dependent synthetase and ligase
AS188_RS04290	COG1268	BioY protein
AS188_RS04300	COG1122	ATPase activity
AS188_RS04325	COG2610	gluconate transmembrane transporter activity
AS188_RS04335	COG2084	Dehydrogenase
AS188_RS04340	COG2186	Transcriptional regulator
AS188_RS04345	COG1028	Short-chain dehydrogenase reductase Sdr
AS188_RS04365	COG0386	Belongs to the glutathione peroxidase family
AS188_RS04375	COG3949	Membrane
AS188_RS04385	COG1966	Carbon starvation protein
AS188_RS04415	COG1028	Short-chain dehydrogenase reductase Sdr
AS188_RS04425	COG1960	acyl-CoA dehydrogenase activity
AS188_RS04435	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AS188_RS04445	COG1960	acyl-CoA dehydrogenase activity
AS188_RS04450	COG2030	dehydratase
AS188_RS04450	COG1012	belongs to the aldehyde dehydrogenase family
AS188_RS04465	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AS188_RS04470	COG1846	Transcriptional regulator
AS188_RS04480	COG4166	transmembrane transport
AS188_RS04490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AS188_RS04495	COG0444	Belongs to the ABC transporter superfamily
AS188_RS04500	COG4608	Belongs to the ABC transporter superfamily
AS188_RS04505	COG1914	H( )-stimulated, divalent metal cation uptake system
AS188_RS04510	COG4336	lyase activity
AS188_RS04520	COG4770	biotin carboxylase activity
AS188_RS04525	COG1984	allophanate hydrolase subunit 2
AS188_RS04530	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AS188_RS04535	COG1940	carbohydrate kinase activity
AS188_RS04540	COG2807	transmembrane transport
AS188_RS04575	COG0697	spore germination
AS188_RS04600	COG1120	ATPase activity
AS188_RS04605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS188_RS04610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS188_RS04625	COG3486	L-lysine 6-monooxygenase (NADPH) activity
AS188_RS04685	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AS188_RS04690	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AS188_RS04710	COG1136	(ABC) transporter
AS188_RS04720	COG4585	Histidine kinase
AS188_RS04725	COG2197	response regulator
AS188_RS04735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS188_RS04740	COG0297	glycogen (starch) synthase activity
AS188_RS04755	COG1522	sequence-specific DNA binding
AS188_RS04760	COG0129	dihydroxy-acid dehydratase activity
AS188_RS04765	COG1028	Short-chain dehydrogenase reductase Sdr
AS188_RS04780	COG1012	belongs to the aldehyde dehydrogenase family
AS188_RS04795	COG2326	polyphosphate kinase activity
AS188_RS04810	COG0477	Major facilitator Superfamily
AS188_RS04830	COG0739	heme binding
AS188_RS04860	COG0438	transferase activity, transferring glycosyl groups
AS188_RS04885	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AS188_RS04890	COG1929	Belongs to the glycerate kinase type-1 family
AS188_RS04895	COG3960	tartronate-semialdehyde synthase activity
AS188_RS04900	COG2084	Dehydrogenase
AS188_RS04905	COG3622	Belongs to the hyi family
AS188_RS04910	COG3257	ureidoglycine aminohydrolase activity
AS188_RS04920	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AS188_RS04930	COG1414	Transcriptional regulator
AS188_RS04935	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AS188_RS04940	COG2233	PERMEase
AS188_RS04950	COG2351	hydroxyisourate hydrolase activity
AS188_RS04960	COG1028	Short-chain dehydrogenase reductase Sdr
AS188_RS04975	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AS188_RS04975	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AS188_RS05030	COG2197	response regulator
AS188_RS05040	COG0277	FAD linked oxidase domain protein
AS188_RS05045	COG0577	efflux transmembrane transporter activity
AS188_RS05045	COG1136	(ABC) transporter
AS188_RS05050	COG1136	(ABC) transporter
AS188_RS05065	COG1396	sequence-specific DNA binding
AS188_RS05075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS188_RS05090	COG1404	Belongs to the peptidase S8 family
AS188_RS05100	COG0463	Glycosyl transferase, family 2
AS188_RS05110	COG0142	geranyltranstransferase activity
AS188_RS05130	COG0508	dehydrogenase complex catalyzes the overall conversion of
AS188_RS05135	COG0022	dehydrogenase e1 component
AS188_RS05150	COG2873	o-acetylhomoserine
AS188_RS05165	COG2897	thiosulfate sulfurtransferase activity
AS188_RS05170	COG0702	epimerase
AS188_RS05200	COG2197	response regulator
AS188_RS05210	COG0477	Major facilitator Superfamily
AS188_RS05215	COG2818	Glycosylase
AS188_RS05240	COG1024	Enoyl-CoA hydratase
AS188_RS05240	COG1250	3-hydroxyacyl-CoA dehydrogenase
AS188_RS05245	COG1960	acyl-CoA dehydrogenase activity
AS188_RS05250	COG0318	PFAM AMP-dependent synthetase and ligase
AS188_RS05280	COG1028	Short-chain dehydrogenase reductase Sdr
AS188_RS05305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS188_RS05345	COG2815	serine threonine protein kinase
AS188_RS05345	COG0515	serine threonine protein kinase
AS188_RS05350	COG0515	serine threonine protein kinase
AS188_RS05355	COG0768	penicillin binding
AS188_RS05370	COG1716	ATPase activity
AS188_RS05375	COG1716	ATPase activity
AS188_RS05380	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AS188_RS05385	COG0446	pyridine nucleotide-disulphide oxidoreductase
AS188_RS05385	COG1902	pentaerythritol trinitrate reductase activity
AS188_RS05395	COG0783	Belongs to the Dps family
AS188_RS05405	COG0471	metal ion transport
AS188_RS05415	COG0444	Belongs to the ABC transporter superfamily
AS188_RS05420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AS188_RS05455	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AS188_RS05465	COG1234	tRNA 3'-trailer cleavage
AS188_RS05505	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AS188_RS05530	COG4989	oxidoreductase activity
AS188_RS05550	COG0693	protein deglycase activity
AS188_RS05550	COG0753	catalase activity
AS188_RS05570	COG0588	phosphoglycerate mutase activity
AS188_RS05575	COG2902	Dehydrogenase
AS188_RS05595	COG0303	'Molybdopterin
AS188_RS05645	COG1140	nitrate reductase beta subunit
AS188_RS05675	COG0315	cyclic pyranopterin monophosphate synthase activity
AS188_RS05680	COG0521	Mo-molybdopterin cofactor biosynthetic process
AS188_RS05685	COG0314	molybdopterin synthase activity
AS188_RS05710	COG1028	Short-chain dehydrogenase reductase Sdr
AS188_RS05725	COG2814	Major facilitator Superfamily
AS188_RS05730	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AS188_RS05755	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AS188_RS05765	COG1266	CAAX protease self-immunity
AS188_RS05770	COG1362	aminopeptidase activity
AS188_RS05785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AS188_RS05850	COG2217	Heavy metal translocating P-type atpase
AS188_RS05855	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AS188_RS05855	COG0574	Belongs to the PEP-utilizing enzyme family
AS188_RS05870	COG2233	PERMEase
AS188_RS05925	COG1012	belongs to the aldehyde dehydrogenase family
AS188_RS05950	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AS188_RS05955	COG0561	phosphatase activity
AS188_RS05960	COG1174	glycine betaine transport
AS188_RS05970	COG1174	glycine betaine transport
AS188_RS05995	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AS188_RS06000	COG2027	D-alanyl-D-alanine carboxypeptidase
AS188_RS06015	COG0037	tRNA processing
AS188_RS06025	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AS188_RS06035	COG0302	gtp cyclohydrolase
AS188_RS06045	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AS188_RS06050	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AS188_RS06075	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AS188_RS06080	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AS188_RS06100	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AS188_RS06115	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AS188_RS06125	COG4129	membrane
AS188_RS06140	COG0581	inorganic phosphate transmembrane transporter activity
AS188_RS06145	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AS188_RS06150	COG0306	phosphate transporter
AS188_RS06165	COG2066	Belongs to the glutaminase family
AS188_RS06165	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AS188_RS06185	COG0477	Major facilitator Superfamily
AS188_RS06190	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AS188_RS06195	COG0514	ATP-dependent DNA helicase (RecQ)
AS188_RS06235	COG1950	PFAM Membrane protein of
AS188_RS06240	COG1505	serine-type exopeptidase activity
AS188_RS06260	COG0415	Belongs to the DNA photolyase family
AS188_RS06265	COG0604	alcohol dehydrogenase
AS188_RS06305	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AS188_RS06310	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AS188_RS06315	COG0626	cystathionine gamma-synthase activity
AS188_RS06330	COG0588	phosphoglycerate mutase activity
AS188_RS06340	COG5002	protein histidine kinase activity
AS188_RS06360	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AS188_RS06365	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AS188_RS06370	COG0215	cysteine-tRNA ligase activity
AS188_RS06375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AS188_RS06390	COG0366	Alpha amylase catalytic
AS188_RS06395	COG0366	Alpha amylase catalytic
AS188_RS06400	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AS188_RS06420	COG0277	FAD linked oxidase domain protein
AS188_RS06430	COG4221	oxidoreductase activity
AS188_RS06435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AS188_RS06510	COG1349	DNA-binding transcription factor activity
AS188_RS06520	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AS188_RS06520	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AS188_RS06520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AS188_RS06525	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AS188_RS06560	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AS188_RS06585	COG0459	protein refolding
AS188_RS06590	COG1285	pathogenesis
AS188_RS06595	COG0328	RNA-DNA hybrid ribonuclease activity
AS188_RS06600	COG2205	protein histidine kinase activity
AS188_RS06605	COG0745	RESPONSE REGULATOR receiver
AS188_RS06615	COG1278	Cold shock
AS188_RS06625	COG2814	Major facilitator Superfamily
AS188_RS06630	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AS188_RS06635	COG1321	iron dependent repressor
AS188_RS06680	COG2814	Major facilitator Superfamily
AS188_RS06690	COG0045	succinate-CoA ligase (ADP-forming) activity
AS188_RS06700	COG1942	4-Oxalocrotonate Tautomerase
AS188_RS06705	COG1082	Xylose isomerase domain protein TIM barrel
AS188_RS06710	COG1082	Xylose isomerase domain protein TIM barrel
AS188_RS06715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AS188_RS06725	COG3962	Belongs to the TPP enzyme family
AS188_RS06735	COG0673	inositol 2-dehydrogenase activity
AS188_RS06740	COG1609	Transcriptional regulator
AS188_RS06755	COG3718	enzyme involved in inositol metabolism
AS188_RS06760	COG2188	Transcriptional regulator
AS188_RS06770	COG4211	Belongs to the binding-protein-dependent transport system permease family
AS188_RS06780	COG1609	Transcriptional regulator
AS188_RS06785	COG0673	inositol 2-dehydrogenase activity
AS188_RS06790	COG0673	inositol 2-dehydrogenase activity
AS188_RS06800	COG1609	Transcriptional regulator
AS188_RS06820	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AS188_RS06830	COG1278	Cold shock
AS188_RS06865	COG0138	bifunctional purine biosynthesis protein purh
AS188_RS06870	COG2838	Isocitrate dehydrogenase
AS188_RS06875	COG0071	Belongs to the small heat shock protein (HSP20) family
AS188_RS06885	COG1309	transcriptional regulator
AS188_RS06900	COG2205	protein histidine kinase activity
AS188_RS06905	COG0745	RESPONSE REGULATOR receiver
AS188_RS06915	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AS188_RS06920	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AS188_RS06930	COG0708	Exodeoxyribonuclease III
AS188_RS06935	COG0180	Tryptophanyl-tRNA synthetase
AS188_RS06940	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AS188_RS06950	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AS188_RS06955	COG1053	succinate dehydrogenase
AS188_RS06965	COG2009	succinate dehydrogenase
AS188_RS06975	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AS188_RS06975	COG1473	amidohydrolase
AS188_RS07000	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AS188_RS07005	COG3956	TIGRFAM MazG family protein
AS188_RS07010	COG0148	phosphopyruvate hydratase activity
AS188_RS07060	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AS188_RS07070	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AS188_RS07080	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AS188_RS07095	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AS188_RS07100	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AS188_RS07115	COG0114	fumarate hydratase activity
AS188_RS07145	COG1316	TRANSCRIPTIONal
AS188_RS07150	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AS188_RS07185	COG1376	ErfK ybiS ycfS ynhG family protein
AS188_RS07215	COG0714	Associated with various cellular activities
AS188_RS07220	COG0084	hydrolase, TatD family'
AS188_RS07230	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AS188_RS07235	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AS188_RS07260	COG1215	transferase activity, transferring glycosyl groups
AS188_RS07280	COG2755	lipolytic protein G-D-S-L family
AS188_RS07280	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AS188_RS07305	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AS188_RS07320	COG0488	(ABC) transporter
AS188_RS07335	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AS188_RS07340	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AS188_RS07380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AS188_RS07385	COG0346	lactoylglutathione lyase activity
AS188_RS07425	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AS188_RS07430	COG3634	alkyl hydroperoxide reductase activity
AS188_RS07440	COG1063	alcohol dehydrogenase
AS188_RS07460	COG1132	(ABC) transporter
AS188_RS07570	COG0596	Alpha beta hydrolase
AS188_RS07600	COG0489	protein tyrosine kinase activity
AS188_RS07605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AS188_RS07610	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AS188_RS07630	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AS188_RS07635	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AS188_RS07645	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AS188_RS07650	COG0193	aminoacyl-tRNA hydrolase activity
AS188_RS07670	COG0463	Glycosyl transferase, family 2
AS188_RS07720	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AS188_RS07725	COG2272	Belongs to the type-B carboxylesterase lipase family
AS188_RS07750	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AS188_RS07760	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AS188_RS07790	COG1648	precorrin-2 dehydrogenase activity
AS188_RS07790	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AS188_RS07800	COG0833	amino acid
AS188_RS07820	COG4974	Belongs to the 'phage' integrase family
AS188_RS07865	COG0542	response to heat
AS188_RS07900	COG2223	nitrite transmembrane transporter activity
AS188_RS07905	COG0243	molybdopterin cofactor binding
AS188_RS07910	COG2146	nitrite reductase [NAD(P)H] activity
AS188_RS07910	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AS188_RS07920	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AS188_RS07920	COG2146	nitrite reductase [NAD(P)H] activity
AS188_RS07925	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AS188_RS07925	COG2146	nitrite reductase [NAD(P)H] activity
AS188_RS07935	COG1115	amino acid carrier protein
AS188_RS07950	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AS188_RS07965	COG0477	Major facilitator Superfamily
AS188_RS07980	COG4770	biotin carboxylase activity
AS188_RS07985	COG0424	maF-like protein
AS188_RS07995	COG1012	belongs to the aldehyde dehydrogenase family
AS188_RS08005	COG1823	symporter activity
AS188_RS08020	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AS188_RS08045	COG0631	protein serine/threonine phosphatase activity
AS188_RS08065	COG0183	Belongs to the thiolase family
AS188_RS08070	COG1028	Short-chain dehydrogenase reductase Sdr
AS188_RS08085	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AS188_RS08090	COG0483	inositol monophosphate 1-phosphatase activity
AS188_RS08095	COG1652	LysM domain
AS188_RS08105	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AS188_RS08110	COG0154	amidase activity
AS188_RS08115	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AS188_RS08145	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AS188_RS08155	COG2501	S4 domain
AS188_RS08160	COG0423	glycine-tRNA ligase activity
AS188_RS08185	COG2814	Major facilitator Superfamily
AS188_RS08190	COG0358	DNA primase activity
AS188_RS08255	COG0052	Belongs to the universal ribosomal protein uS2 family
AS188_RS08260	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AS188_RS08265	COG0528	UMP kinase activity
AS188_RS08270	COG0233	cytoplasmic translational termination
AS188_RS08275	COG0575	Belongs to the CDS family
AS188_RS08290	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AS188_RS08295	COG2261	transglycosylase associated protein
AS188_RS08300	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AS188_RS08305	COG1464	Belongs to the NlpA lipoprotein family
AS188_RS08310	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AS188_RS08320	COG0750	zinc metalloprotease
AS188_RS08325	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AS188_RS08335	COG0442	prolyl-tRNA aminoacylation
AS188_RS08350	COG0779	Required for maturation of 30S ribosomal subunits
AS188_RS08365	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AS188_RS08370	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AS188_RS08375	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AS188_RS08405	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AS188_RS08410	COG1185	polyribonucleotide nucleotidyltransferase activity
AS188_RS08415	COG0612	Peptidase, M16
AS188_RS08420	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AS188_RS08430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AS188_RS08435	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AS188_RS08440	COG1674	ftsk spoiiie
AS188_RS08450	COG1058	Belongs to the CinA family
AS188_RS08450	COG1546	Belongs to the CinA family
AS188_RS08455	COG1396	sequence-specific DNA binding
AS188_RS08465	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AS188_RS08470	COG2137	regulation of response to DNA damage stimulus
AS188_RS08480	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AS188_RS08485	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AS188_RS08490	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AS188_RS08495	COG2813	Specifically methylates the guanine in position
AS188_RS08500	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AS188_RS08510	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AS188_RS08520	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AS188_RS08525	COG0131	Imidazoleglycerol-phosphate dehydratase
AS188_RS08530	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AS188_RS08535	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AS188_RS08555	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AS188_RS08560	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AS188_RS08565	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AS188_RS08570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AS188_RS08585	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AS188_RS08590	COG0072	phenylalanine-tRNA ligase activity
AS188_RS08590	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AS188_RS08610	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AS188_RS08615	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AS188_RS08620	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AS188_RS08625	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AS188_RS08630	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AS188_RS08635	COG1438	arginine binding
AS188_RS08645	COG0318	PFAM AMP-dependent synthetase and ligase
AS188_RS08650	COG0753	catalase activity
AS188_RS08655	COG0137	argininosuccinate synthase activity
AS188_RS08660	COG0165	Argininosuccinate lyase
AS188_RS08665	COG2094	Belongs to the DNA glycosylase MPG family
AS188_RS08670	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AS188_RS08680	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AS188_RS08705	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AS188_RS08715	COG0647	UMP catabolic process
AS188_RS08730	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AS188_RS08735	COG0497	DNA recombination
AS188_RS08740	COG0504	CTP synthase activity
AS188_RS08745	COG0494	nUDIX hydrolase
AS188_RS08765	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AS188_RS08775	COG1802	Transcriptional regulator
AS188_RS08785	COG4565	transcriptional regulatory protein
AS188_RS08790	COG3290	protein histidine kinase activity
AS188_RS08795	COG1301	dicarboxylic acid transport
AS188_RS08805	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AS188_RS08810	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AS188_RS08820	COG0287	Prephenate dehydrogenase
AS188_RS08825	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AS188_RS08830	COG1160	GTP binding
AS188_RS08845	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AS188_RS08850	COG0509	glycine decarboxylation via glycine cleavage system
AS188_RS08855	COG1716	ATPase activity
AS188_RS08890	COG1022	Amp-dependent synthetase and ligase
AS188_RS08910	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AS188_RS08915	COG0515	serine threonine protein kinase
AS188_RS08915	COG2815	serine threonine protein kinase
AS188_RS08920	COG1705	Flagellar rod assembly protein muramidase FlgJ
AS188_RS08920	COG1388	LysM domain
AS188_RS08930	COG0142	geranyltranstransferase activity
AS188_RS08935	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AS188_RS08945	COG2001	Belongs to the MraZ family
AS188_RS08950	COG0275	rRNA processing
AS188_RS08960	COG0768	penicillin binding
AS188_RS08965	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AS188_RS08975	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AS188_RS08980	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AS188_RS08990	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AS188_RS08995	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AS188_RS09000	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AS188_RS09005	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AS188_RS09010	COG1496	oxidoreductase activity
AS188_RS09015	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AS188_RS09020	COG1799	cell septum assembly
AS188_RS09030	COG3599	regulation of cell shape
AS188_RS09035	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AS188_RS09045	COG0587	DNA-directed DNA polymerase activity
AS188_RS09050	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AS188_RS09055	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AS188_RS09070	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AS188_RS09075	COG0174	glutamine synthetase
AS188_RS09080	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AS188_RS09085	COG0174	glutamine synthetase
AS188_RS09100	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AS188_RS09105	COG0321	lipoyl(octanoyl) transferase activity
AS188_RS09120	COG0508	dehydrogenase complex catalyzes the overall conversion of
AS188_RS09125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AS188_RS09130	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AS188_RS09150	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AS188_RS09165	COG0039	L-malate dehydrogenase activity
AS188_RS09170	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AS188_RS09180	COG0515	serine threonine protein kinase
AS188_RS09215	COG0756	dUTP diphosphatase activity
AS188_RS09240	COG0569	domain protein
AS188_RS09245	COG0531	amino acid
AS188_RS09250	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AS188_RS09255	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AS188_RS09260	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AS188_RS09285	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AS188_RS09295	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AS188_RS09340	COG0242	peptide deformylase activity
AS188_RS09345	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AS188_RS09355	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AS188_RS09370	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AS188_RS09370	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AS188_RS09375	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AS188_RS09375	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AS188_RS09380	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AS188_RS09385	COG0140	phosphoribosyl-ATP diphosphatase activity
AS188_RS09390	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AS188_RS09395	COG0107	imidazoleglycerol-phosphate synthase activity
AS188_RS09400	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AS188_RS09420	COG0133	tryptophan synthase activity
AS188_RS09425	COG0159	tryptophan synthase activity
AS188_RS09430	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AS188_RS09435	COG0069	glutamate synthase activity
AS188_RS09435	COG0070	glutamate synthase
AS188_RS09435	COG0067	glutamate synthase
AS188_RS09450	COG2050	protein possibly involved in aromatic compounds catabolism
AS188_RS09470	COG4552	Acetyltransferase involved in intracellular survival and related
AS188_RS09475	COG0539	negative regulation of cytoplasmic translation
AS188_RS09480	COG1739	Uncharacterized protein family UPF0029
AS188_RS09485	COG0237	dephospho-CoA kinase activity
AS188_RS09485	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AS188_RS09490	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AS188_RS09510	COG2304	oxidoreductase activity
AS188_RS09530	COG3001	Fructosamine kinase
AS188_RS09535	COG0569	domain protein
AS188_RS09540	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AS188_RS09545	COG0702	epimerase
AS188_RS09550	COG0556	nucleotide-excision repair
AS188_RS09575	COG0385	Bile acid
AS188_RS09590	COG2814	Major facilitator Superfamily
AS188_RS09605	COG0322	excinuclease ABC activity
AS188_RS09610	COG1660	Displays ATPase and GTPase activities
AS188_RS09615	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AS188_RS09620	COG1481	regulation of sporulation
AS188_RS09625	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AS188_RS09630	COG0126	phosphoglycerate kinase activity
AS188_RS09635	COG0149	triose-phosphate isomerase activity
AS188_RS09640	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AS188_RS09645	COG0363	glucosamine-6-phosphate deaminase activity
AS188_RS09660	COG0166	Belongs to the GPI family
AS188_RS09665	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AS188_RS09675	COG0109	protoheme IX farnesyltransferase activity
AS188_RS09680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AS188_RS09695	COG1131	(ABC) transporter
AS188_RS09715	COG0396	ATPase activity
AS188_RS09720	COG2151	metal-sulfur cluster biosynthetic enzyme
AS188_RS09745	COG1268	BioY protein
AS188_RS09755	COG0488	(ABC) transporter
AS188_RS09760	COG2239	Acts as a magnesium transporter
AS188_RS09785	COG1028	Short-chain dehydrogenase reductase Sdr
AS188_RS09800	COG0560	Phosphoserine phosphatase
AS188_RS09800	COG3830	Belongs to the UPF0237 family
AS188_RS09805	COG1119	ATPase activity
AS188_RS09825	COG0254	rRNA binding
AS188_RS09840	COG0438	transferase activity, transferring glycosyl groups
AS188_RS09845	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AS188_RS09850	COG4521	taurine ABC transporter
AS188_RS09855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AS188_RS09880	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AS188_RS09915	COG2192	nodulation
AS188_RS09935	COG0297	glycogen (starch) synthase activity
AS188_RS09940	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AS188_RS09940	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AS188_RS09950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AS188_RS09960	COG0463	Glycosyl transferase, family 2
AS188_RS09970	COG2124	cytochrome p450
AS188_RS09985	COG1305	Transglutaminase-like
AS188_RS09990	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AS188_RS09995	COG0297	glycogen (starch) synthase activity
AS188_RS10085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AS188_RS10115	COG0477	Major facilitator Superfamily
AS188_RS10155	COG1733	regulation of RNA biosynthetic process
AS188_RS10160	COG2910	NAD(P)H-binding
AS188_RS10170	COG0471	metal ion transport
AS188_RS10190	COG1929	Belongs to the glycerate kinase type-1 family
AS188_RS10205	COG0471	metal ion transport
AS188_RS10225	COG0673	inositol 2-dehydrogenase activity
AS188_RS10230	COG1172	Belongs to the binding-protein-dependent transport system permease family
AS188_RS10240	COG0673	inositol 2-dehydrogenase activity
AS188_RS10265	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AS188_RS10295	COG4829	muconolactone delta-isomerase
AS188_RS10305	COG3485	protocatechuate 3,4-dioxygenase
AS188_RS10335	COG3328	transposase activity
AS188_RS10340	COG2963	transposase activity
AS188_RS10375	COG0822	iron-sulfur transferase activity
AS188_RS10380	COG0469	pyruvate kinase activity
AS188_RS10395	COG1609	Transcriptional regulator
AS188_RS10400	COG0366	Alpha amylase catalytic
AS188_RS10405	COG3842	ATPase activity
AS188_RS10415	COG1175	transmembrane transport
AS188_RS10420	COG3833	ABC-type maltose transport systems, permease component
AS188_RS10435	COG3328	transposase activity
AS188_RS10465	COG1028	Short-chain dehydrogenase reductase Sdr
AS188_RS10540	COG1876	peptidase activity
AS188_RS10550	COG0243	molybdopterin cofactor binding
AS188_RS10565	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AS188_RS10580	COG0297	glycogen (starch) synthase activity
AS188_RS10590	COG0346	lactoylglutathione lyase activity
AS188_RS10660	COG1435	thymidine kinase activity
AS188_RS10670	COG2807	transmembrane transport
AS188_RS10690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS188_RS10700	COG3546	catalase activity
AS188_RS10705	COG1064	alcohol dehydrogenase
AS188_RS10715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AS188_RS10735	COG1968	undecaprenyl-diphosphatase activity
AS188_RS10740	COG0215	cysteine-tRNA ligase activity
AS188_RS10750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AS188_RS10755	COG0517	IMP dehydrogenase activity
AS188_RS10755	COG1994	Peptidase M50
AS188_RS10765	COG1222	aaa ATPase
AS188_RS10770	COG4122	O-methyltransferase activity
AS188_RS10780	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AS188_RS10785	COG0544	peptidyl-prolyl cis-trans isomerase activity
AS188_RS10795	COG2378	regulation of single-species biofilm formation
AS188_RS10805	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AS188_RS10810	COG0805	protein transport
AS188_RS10815	COG4581	dead DEAH box helicase
AS188_RS10820	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AS188_RS10865	COG4974	Belongs to the 'phage' integrase family
AS188_RS10880	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AS188_RS10885	COG1845	cytochrome c oxidase, subunit III
AS188_RS10890	COG2010	Cytochrome c
AS188_RS10895	COG0723	plastoquinol--plastocyanin reductase activity
AS188_RS10900	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AS188_RS10910	COG1484	DNA-dependent DNA replication
AS188_RS10930	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AS188_RS10935	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AS188_RS10955	COG0167	dihydroorotate dehydrogenase activity
AS188_RS10965	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AS188_RS10970	COG1381	Involved in DNA repair and RecF pathway recombination
AS188_RS10975	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AS188_RS10980	COG1316	TRANSCRIPTIONal
AS188_RS10985	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AS188_RS10995	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AS188_RS11015	COG0484	heat shock protein binding
AS188_RS11020	COG1420	regulation of RNA biosynthetic process
AS188_RS11040	COG0481	GTPase activity
AS188_RS11055	COG0268	Binds directly to 16S ribosomal RNA
AS188_RS11065	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AS188_RS11080	COG1307	EDD domain protein, DegV family
AS188_RS11085	COG0495	leucyl-tRNA aminoacylation
AS188_RS11095	COG0438	transferase activity, transferring glycosyl groups
AS188_RS11115	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AS188_RS11125	COG1758	RNA polymerase activity
AS188_RS11130	COG0194	GDP metabolic process
AS188_RS11135	COG0194	GDP metabolic process
AS188_RS11140	COG0284	orotidine-5'-phosphate decarboxylase activity
AS188_RS11145	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AS188_RS11150	COG0505	Belongs to the CarA family
AS188_RS11160	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AS188_RS11165	COG0540	Belongs to the ATCase OTCase family
AS188_RS11170	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AS188_RS11175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AS188_RS11180	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AS188_RS11185	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AS188_RS11195	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AS188_RS11200	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AS188_RS11210	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AS188_RS11215	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AS188_RS11230	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AS188_RS11235	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AS188_RS11240	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AS188_RS11245	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AS188_RS11250	COG2390	Transcriptional regulator
AS188_RS11265	COG1490	D-aminoacyl-tRNA deacylase activity
AS188_RS11275	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AS188_RS11285	COG0124	histidyl-tRNA synthetase
AS188_RS11290	COG1196	nuclear chromosome segregation
AS188_RS11300	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AS188_RS11305	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AS188_RS11310	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AS188_RS11320	COG2255	four-way junction helicase activity
AS188_RS11325	COG0632	four-way junction helicase activity
AS188_RS11330	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AS188_RS11335	COG0217	transcriptional regulatory protein
AS188_RS11340	COG1492	cobalamin metabolic process
AS188_RS11355	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AS188_RS11360	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
AS188_RS11365	COG0587	DNA-directed DNA polymerase activity
AS188_RS11380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS188_RS11385	COG0179	Fumarylacetoacetate (FAA) hydrolase
AS188_RS11420	COG2135	peptidase activity
AS188_RS11435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS188_RS11445	COG0822	iron-sulfur transferase activity
AS188_RS11455	COG0492	ferredoxin-NADP+ reductase activity
AS188_RS11470	COG0778	Nitroreductase
AS188_RS11480	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AS188_RS11495	COG3655	Transcriptional regulator
AS188_RS11510	COG2315	Protein conserved in bacteria
AS188_RS11520	COG1204	response to ionizing radiation
AS188_RS11565	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AS188_RS11570	COG2826	transposase and inactivated derivatives, IS30 family
AS188_RS11605	COG1780	Probably involved in ribonucleotide reductase function
AS188_RS11615	COG1012	belongs to the aldehyde dehydrogenase family
AS188_RS11625	COG1063	alcohol dehydrogenase
AS188_RS11640	COG0464	growth
AS188_RS11660	COG3621	Patatin-like phospholipase
AS188_RS11665	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AS188_RS11690	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AS188_RS11700	COG0477	Major facilitator Superfamily
AS188_RS11725	COG1388	LysM domain
AS188_RS11730	COG2217	Heavy metal translocating P-type atpase
AS188_RS11735	COG1937	Protein conserved in bacteria
AS188_RS11780	COG1196	nuclear chromosome segregation
AS188_RS11780	COG0739	heme binding
AS188_RS11780	COG0741	lytic transglycosylase activity
AS188_RS11815	COG2814	Major facilitator Superfamily
AS188_RS11820	COG0640	Transcriptional regulator
AS188_RS11855	COG0799	negative regulation of ribosome biogenesis
AS188_RS11865	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AS188_RS11875	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AS188_RS11880	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AS188_RS11885	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AS188_RS11890	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AS188_RS11895	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AS188_RS11900	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AS188_RS11900	COG0352	thiamine-phosphate diphosphorylase activity
AS188_RS11900	COG0351	phosphomethylpyrimidine kinase
AS188_RS11905	COG0352	thiamine-phosphate diphosphorylase activity
AS188_RS11910	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AS188_RS11915	COG1530	ribonuclease E activity
AS188_RS11925	COG0105	UTP biosynthetic process
AS188_RS11935	COG0285	dihydrofolate synthase activity
AS188_RS11940	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AS188_RS11950	COG0525	valine-tRNA ligase activity
AS188_RS11955	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AS188_RS11960	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AS188_RS11965	COG0740	serine-type endopeptidase activity
AS188_RS11970	COG0740	serine-type endopeptidase activity
AS188_RS11975	COG0544	peptidyl-prolyl cis-trans isomerase activity
AS188_RS12000	COG0698	ribose 5-phosphate isomerase
AS188_RS12025	COG1946	Acyl-CoA thioesterase
AS188_RS12065	COG0242	peptide deformylase activity
AS188_RS12070	COG3022	response to hydroperoxide
AS188_RS12080	COG0583	DNA-binding transcription factor activity
AS188_RS12090	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AS188_RS12095	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AS188_RS12105	COG1045	serine acetyltransferase
AS188_RS12110	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AS188_RS12135	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AS188_RS12150	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AS188_RS12155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AS188_RS12190	COG0792	nuclease activity
AS188_RS12200	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AS188_RS12205	COG0681	Belongs to the peptidase S26 family
AS188_RS12210	COG0681	Belongs to the peptidase S26 family
AS188_RS12215	COG0335	large ribosomal subunit rRNA binding
AS188_RS12220	COG0336	Belongs to the RNA methyltransferase TrmD family
AS188_RS12225	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AS188_RS12230	COG1837	Belongs to the UPF0109 family
AS188_RS12235	COG0228	four-way junction DNA binding
AS188_RS12245	COG4152	abc transporter atp-binding protein
AS188_RS12250	COG2197	response regulator
AS188_RS12255	COG4585	Histidine kinase
AS188_RS12290	COG0477	Major facilitator Superfamily
AS188_RS12295	COG1196	nuclear chromosome segregation
AS188_RS12300	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AS188_RS12305	COG0318	PFAM AMP-dependent synthetase and ligase
AS188_RS12310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AS188_RS12315	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AS188_RS12320	COG0571	ribonuclease III activity
AS188_RS12325	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AS188_RS12335	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AS188_RS12345	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AS188_RS12360	COG1461	Dihydroxyacetone kinase
AS188_RS12385	COG1181	Belongs to the D-alanine--D-alanine ligase family
AS188_RS12390	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AS188_RS12400	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AS188_RS12405	COG0066	3-isopropylmalate dehydratase activity
AS188_RS12410	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AS188_RS12420	COG1160	GTP binding
AS188_RS12445	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AS188_RS12475	COG1764	response to oxidative stress
AS188_RS12495	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AS188_RS12500	COG0179	Fumarylacetoacetate (FAA) hydrolase
AS188_RS12505	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AS188_RS12510	COG0473	3-isopropylmalate dehydrogenase activity
AS188_RS12520	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AS188_RS12525	COG0440	acetolactate synthase activity
AS188_RS12555	COG0747	negative chemotaxis
AS188_RS12560	COG0579	oxidoreductase
AS188_RS12565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AS188_RS12570	COG1846	Transcriptional regulator
AS188_RS12575	COG1295	ribonuclease BN
AS188_RS12590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS188_RS12615	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AS188_RS12620	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AS188_RS12625	COG1234	tRNA 3'-trailer cleavage
AS188_RS12630	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AS188_RS12640	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AS188_RS12650	COG1335	isochorismatase
AS188_RS12685	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
AS188_RS12695	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AS188_RS12700	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AS188_RS12705	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AS188_RS12710	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AS188_RS12715	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AS188_RS12720	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AS188_RS12725	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AS188_RS12730	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AS188_RS12735	COG0356	it plays a direct role in the translocation of protons across the membrane
AS188_RS12750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AS188_RS12755	COG1086	Polysaccharide biosynthesis protein
AS188_RS12765	COG1216	Glycosyl transferase, family 2
AS188_RS12775	COG0009	L-threonylcarbamoyladenylate synthase
AS188_RS12780	COG2890	protein-(glutamine-N5) methyltransferase activity
AS188_RS12785	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AS188_RS12795	COG0083	homoserine kinase activity
AS188_RS12800	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AS188_RS12805	COG0460	homoserine dehydrogenase
AS188_RS12815	COG0018	arginyl-trna synthetase
AS188_RS12835	COG1122	ATPase activity
AS188_RS12850	COG1643	Atp-dependent helicase
AS188_RS12880	COG1253	flavin adenine dinucleotide binding
AS188_RS12905	COG1595	DNA-templated transcription, initiation
AS188_RS12915	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AS188_RS12920	COG1162	GTPase activity
AS188_RS12925	COG0483	inositol monophosphate 1-phosphatase activity
AS188_RS12935	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AS188_RS12940	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AS188_RS12945	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AS188_RS13010	COG1216	Glycosyl transferase, family 2
AS188_RS13020	COG0438	transferase activity, transferring glycosyl groups
AS188_RS13070	COG0653	protein targeting
AS188_RS13075	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AS188_RS13085	COG5401	PFAM Sporulation and spore germination
AS188_RS13090	COG5002	protein histidine kinase activity
AS188_RS13090	COG5000	phosphorelay sensor kinase activity
AS188_RS13095	COG0745	RESPONSE REGULATOR receiver
AS188_RS13105	COG1605	Chorismate mutase
AS188_RS13105	COG0287	Prephenate dehydrogenase
AS188_RS13110	COG0482	sulfurtransferase activity
AS188_RS13120	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AS188_RS13125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AS188_RS13135	COG1842	Phage shock protein A
AS188_RS13145	COG1615	UPF0182 protein
AS188_RS13150	COG3480	Lon protease (S16) C-terminal proteolytic domain
AS188_RS13185	COG0210	DNA helicase
AS188_RS13190	COG1074	ATP-dependent DNA helicase activity
AS188_RS13200	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AS188_RS13205	COG0113	porphobilinogen synthase activity
AS188_RS13215	COG0181	hydroxymethylbilane synthase activity
AS188_RS13220	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AS188_RS13225	COG3253	May function as heme-dependent peroxidase
AS188_RS13235	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AS188_RS13240	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AS188_RS13245	COG1309	transcriptional regulator
AS188_RS13255	COG0513	Belongs to the DEAD box helicase family
AS188_RS13260	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AS188_RS13275	COG0006	proline dipeptidase activity
AS188_RS13285	COG2239	Acts as a magnesium transporter
AS188_RS13300	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AS188_RS13325	COG1126	abc transporter atp-binding protein
AS188_RS13330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS188_RS13335	COG0765	amino acid transport
AS188_RS13340	COG0765	amino acid transport
AS188_RS13345	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AS188_RS13350	COG2171	N-acyltransferase activity
AS188_RS13360	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AS188_RS13370	COG3547	Transposase (IS116 IS110 IS902 family)
AS188_RS13395	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AS188_RS13400	COG1217	gtp-binding protein TYPA
AS188_RS13405	COG1403	HNH endonuclease
AS188_RS13420	COG0477	Major facilitator Superfamily
AS188_RS13430	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AS188_RS13505	COG0437	4 iron, 4 sulfur cluster binding
AS188_RS13510	COG3383	formate dehydrogenase (NAD+) activity
AS188_RS13510	COG0243	molybdopterin cofactor binding
AS188_RS13515	COG3383	formate dehydrogenase (NAD+) activity
AS188_RS13515	COG0243	molybdopterin cofactor binding
AS188_RS13520	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AS188_RS13535	COG1484	DNA-dependent DNA replication
AS188_RS13545	COG0596	Alpha beta hydrolase
AS188_RS13550	COG3093	addiction module antidote protein HigA
AS188_RS13555	COG2153	protein acetylation
AS188_RS13570	COG1131	(ABC) transporter
AS188_RS13585	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AS188_RS13595	COG1570	exodeoxyribonuclease VII activity
AS188_RS13600	COG1722	exodeoxyribonuclease VII activity
AS188_RS13605	COG2326	polyphosphate kinase activity
AS188_RS13625	COG0598	Magnesium transport protein CorA
AS188_RS13630	COG0586	Pfam SNARE associated Golgi protein
AS188_RS13635	COG0668	transmembrane transport
AS188_RS13670	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AS188_RS13675	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AS188_RS13700	COG0519	Catalyzes the synthesis of GMP from XMP
AS188_RS13700	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AS188_RS13735	COG0459	protein refolding
AS188_RS13740	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AS188_RS13770	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AS188_RS13775	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AS188_RS13790	COG0802	atpase or kinase
AS188_RS13795	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AS188_RS13800	COG0297	glycogen (starch) synthase activity
AS188_RS13815	COG1280	lysine exporter protein (LysE YggA)
AS188_RS13820	COG0667	Aldo Keto reductase
AS188_RS13845	COG0736	holo-[acyl-carrier-protein] synthase activity
AS188_RS13850	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AS188_RS13855	COG0246	Mannitol dehydrogenase
AS188_RS13860	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AS188_RS13860	COG2213	PTS system mannitol-specific
AS188_RS13865	COG1072	(Pantothenic acid kinase))
AS188_RS13875	COG1970	mechanosensitive ion channel activity
AS188_RS13880	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AS188_RS13885	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AS188_RS13890	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AS188_RS13895	COG0101	tRNA pseudouridine synthase activity
AS188_RS13900	COG0203	ribosomal protein L17
AS188_RS13905	COG0202	RNA polymerase activity
AS188_RS13910	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AS188_RS13915	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AS188_RS13920	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AS188_RS13925	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AS188_RS13930	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AS188_RS13940	COG0563	adenylate kinase activity
AS188_RS13950	COG0200	Binds to the 23S rRNA
AS188_RS13955	COG1841	ribosomal large subunit assembly
AS188_RS13960	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AS188_RS13965	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AS188_RS13970	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AS188_RS13975	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AS188_RS13980	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AS188_RS13985	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AS188_RS13990	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AS188_RS13995	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AS188_RS14000	COG0255	Belongs to the universal ribosomal protein uL29 family
AS188_RS14005	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AS188_RS14010	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AS188_RS14015	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AS188_RS14020	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AS188_RS14025	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AS188_RS14030	COG0089	rRNA binding
AS188_RS14040	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AS188_RS14045	COG0051	transcription antitermination factor activity, RNA binding
AS188_RS14050	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AS188_RS14055	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AS188_RS14060	COG0049	tRNA binding
AS188_RS14065	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AS188_RS14070	COG1414	Transcriptional regulator
AS188_RS14075	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AS188_RS14085	COG0183	Belongs to the thiolase family
AS188_RS14090	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AS188_RS14095	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AS188_RS14100	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AS188_RS14105	COG3485	protocatechuate 3,4-dioxygenase
AS188_RS14110	COG3485	protocatechuate 3,4-dioxygenase
AS188_RS14125	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AS188_RS14130	COG0085	RNA polymerase activity
AS188_RS14135	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AS188_RS14140	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AS188_RS14140	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AS188_RS14145	COG0222	ribosome binding
AS188_RS14150	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AS188_RS14160	COG0081	regulation of translation
AS188_RS14165	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AS188_RS14175	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AS188_RS14185	COG0436	Aminotransferase
AS188_RS14195	COG2326	polyphosphate kinase activity
AS188_RS14205	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AS188_RS14210	COG3485	protocatechuate 3,4-dioxygenase
AS188_RS14220	COG0745	RESPONSE REGULATOR receiver
AS188_RS14225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS188_RS14225	COG0456	acetyltransferase
AS188_RS14230	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AS188_RS14235	COG0406	alpha-ribazole phosphatase activity
AS188_RS14235	COG0494	nUDIX hydrolase
AS188_RS14240	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AS188_RS14245	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AS188_RS14255	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AS188_RS14265	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AS188_RS14275	COG2030	dehydratase
AS188_RS14300	COG1132	(ABC) transporter
AS188_RS14320	COG0745	RESPONSE REGULATOR receiver
AS188_RS14325	COG5002	protein histidine kinase activity
AS188_RS14350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AS188_RS14355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS188_RS14380	COG1666	GTP binding
AS188_RS14385	COG0501	Belongs to the peptidase M48B family
AS188_RS14420	COG0733	neurotransmitter:sodium symporter activity
AS188_RS14425	COG0142	geranyltranstransferase activity
AS188_RS14435	COG2226	methyltransferase
AS188_RS14440	COG1169	isochorismate synthase
AS188_RS14445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS188_RS14450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS188_RS14455	COG0765	amino acid transport
AS188_RS14470	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AS188_RS14480	COG4948	Mandelate Racemase Muconate Lactonizing
AS188_RS14495	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AS188_RS14500	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AS188_RS14515	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AS188_RS14520	COG0039	L-malate dehydrogenase activity
AS188_RS14535	COG1643	Atp-dependent helicase
AS188_RS14540	COG0596	Alpha beta hydrolase
AS188_RS14545	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AS188_RS14570	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AS188_RS14580	COG0785	Cytochrome C biogenesis protein
AS188_RS14590	COG0406	alpha-ribazole phosphatase activity
AS188_RS14600	COG1802	Transcriptional regulator
AS188_RS14605	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AS188_RS14615	COG0123	including yeast histone deacetylase and acetoin utilization protein
AS188_RS14620	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AS188_RS14625	COG0569	domain protein
AS188_RS14635	COG1082	Xylose isomerase domain protein TIM barrel
AS188_RS14640	COG0248	Ppx GppA phosphatase
AS188_RS14645	COG1754	DNA topoisomerase type I activity
AS188_RS14645	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AS188_RS14655	COG2890	protein-(glutamine-N5) methyltransferase activity
AS188_RS14665	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AS188_RS14675	COG1349	DNA-binding transcription factor activity
AS188_RS14690	COG0395	ABC-type sugar transport system, permease component
AS188_RS14700	COG3842	ATPase activity
AS188_RS14710	COG0366	Alpha amylase catalytic
AS188_RS14715	COG1205	dead DEAH box helicase
AS188_RS14715	COG1111	helicase
AS188_RS14765	COG0494	nUDIX hydrolase
AS188_RS14775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AS188_RS14780	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AS188_RS14785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AS188_RS14810	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AS188_RS14815	COG1408	metallophosphoesterase
AS188_RS14830	COG1846	Transcriptional regulator
AS188_RS14835	COG2130	NADP-dependent
AS188_RS14840	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AS188_RS14845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AS188_RS14880	COG3328	transposase activity
AS188_RS14910	COG2894	cell division
AS188_RS14955	COG1819	glycosyl
AS188_RS14965	COG1556	Lactate utilization protein
AS188_RS14970	COG1139	Iron-sulfur cluster binding protein
AS188_RS14975	COG0247	lactate metabolic process
AS188_RS14980	COG1620	l-lactate permease
AS188_RS14985	COG2186	Transcriptional regulator
AS188_RS14990	COG2197	response regulator
AS188_RS14995	COG4585	Histidine kinase
AS188_RS15005	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AS188_RS15010	COG0151	Belongs to the GarS family
AS188_RS15100	COG1937	Protein conserved in bacteria
AS188_RS15105	COG2217	Heavy metal translocating P-type atpase
AS188_RS15125	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AS188_RS15130	COG0589	response to stress
AS188_RS15135	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AS188_RS15150	COG2132	Multicopper oxidase
AS188_RS15155	COG0745	RESPONSE REGULATOR receiver
AS188_RS15160	COG2205	protein histidine kinase activity
AS188_RS15170	COG2217	Heavy metal translocating P-type atpase
AS188_RS15235	COG0745	RESPONSE REGULATOR receiver
AS188_RS15240	COG2205	protein histidine kinase activity
AS188_RS15270	COG1937	Protein conserved in bacteria
AS188_RS15310	COG2814	Major facilitator Superfamily
AS188_RS15330	COG0789	Transcriptional regulator
AS188_RS15335	COG0659	secondary active sulfate transmembrane transporter activity
AS188_RS15340	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AS188_RS15340	COG2755	lipolytic protein G-D-S-L family
AS188_RS15365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AS188_RS15370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AS188_RS15375	COG0513	Belongs to the DEAD box helicase family
AS188_RS15405	COG1115	amino acid carrier protein
AS188_RS15415	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AS188_RS15425	COG0789	Transcriptional regulator
AS188_RS15430	COG0484	heat shock protein binding
AS188_RS15435	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AS188_RS15440	COG0443	Heat shock 70 kDa protein
AS188_RS15445	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AS188_RS15450	COG0572	uridine kinase
AS188_RS15465	COG4172	Belongs to the ABC transporter superfamily
AS188_RS15470	COG4721	ABC-type cobalt transport system, permease component
AS188_RS15480	COG1320	monovalent cation:proton antiporter activity
AS188_RS15485	COG2212	antiporter activity
AS188_RS15495	COG0651	ATP synthesis coupled electron transport
AS188_RS15500	COG1006	Multisubunit Na H antiporter MnhC subunit
AS188_RS15505	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AS188_RS15505	COG2111	Na H antiporter
AS188_RS15520	COG0717	Belongs to the dCTP deaminase family
AS188_RS15530	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AS188_RS15580	COG2837	iron assimilation
AS188_RS15600	COG0776	regulation of translation
AS188_RS15605	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AS188_RS15610	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AS188_RS15615	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AS188_RS15630	COG1064	alcohol dehydrogenase
AS188_RS15635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS188_RS15640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AS188_RS15650	COG0435	Glutathione S-transferase
AS188_RS15675	COG4638	Rieske (2fe-2S)
AS188_RS15940	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AS188_RS15940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS188_RS16015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AS188_RS16085	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AS188_RS16145	COG0277	FAD linked oxidase domain protein