locus-tag	class	description
KRH_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KRH_RS00015	COG0592	DNA-directed DNA polymerase activity
KRH_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KRH_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
KRH_RS00030	COG0187	DNA topoisomerase II activity
KRH_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KRH_RS00055	COG1914	H( )-stimulated, divalent metal cation uptake system
KRH_RS00075	COG2814	Major facilitator Superfamily
KRH_RS00095	COG1063	alcohol dehydrogenase
KRH_RS00105	COG0028	Belongs to the TPP enzyme family
KRH_RS00110	COG0477	Major facilitator Superfamily
KRH_RS00130	COG0531	amino acid
KRH_RS00135	COG3104	oligopeptide transport
KRH_RS00140	COG0656	L-ascorbic acid biosynthetic process
KRH_RS00165	COG1132	(ABC) transporter
KRH_RS00180	COG1174	glycine betaine transport
KRH_RS00185	COG1174	glycine betaine transport
KRH_RS00205	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KRH_RS00210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KRH_RS00230	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KRH_RS00235	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
KRH_RS00245	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
KRH_RS00255	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KRH_RS00275	COG0693	protein deglycase activity
KRH_RS00285	COG1780	Probably involved in ribonucleotide reductase function
KRH_RS00290	COG1760	l-serine dehydratase
KRH_RS00295	COG0798	PFAM Bile acid sodium symporter
KRH_RS00325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KRH_RS00340	COG2971	BadF BadG BcrA BcrD
KRH_RS00355	COG3237	CsbD-like
KRH_RS00375	COG1741	Belongs to the pirin family
KRH_RS00430	COG0531	amino acid
KRH_RS00440	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
KRH_RS00445	COG1012	belongs to the aldehyde dehydrogenase family
KRH_RS00505	COG1126	abc transporter atp-binding protein
KRH_RS00510	COG0765	amino acid transport
KRH_RS00515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KRH_RS00520	COG0626	cystathionine gamma-synthase activity
KRH_RS00525	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
KRH_RS00530	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
KRH_RS00540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KRH_RS00560	COG2608	mercury ion transmembrane transporter activity
KRH_RS00565	COG1937	Protein conserved in bacteria
KRH_RS00590	COG1321	iron dependent repressor
KRH_RS00605	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KRH_RS00610	COG1121	(ABC) transporter
KRH_RS00615	COG0803	Belongs to the bacterial solute-binding protein 9 family
KRH_RS00625	COG3387	PFAM Glycoside hydrolase 15-related
KRH_RS00630	COG1012	belongs to the aldehyde dehydrogenase family
KRH_RS00680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KRH_RS00700	COG2233	PERMEase
KRH_RS00710	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KRH_RS00715	COG0280	phosphate acetyltransferase
KRH_RS00715	COG0857	belongs to the CobB CobQ family
KRH_RS00730	COG2252	PERMEase
KRH_RS00735	COG0493	'glutamate synthase
KRH_RS00740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KRH_RS00745	COG0277	FAD linked oxidase domain protein
KRH_RS00775	COG0366	Alpha amylase catalytic
KRH_RS00795	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KRH_RS00800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KRH_RS00805	COG1028	Short-chain dehydrogenase reductase Sdr
KRH_RS00810	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KRH_RS00815	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KRH_RS00845	COG1131	(ABC) transporter
KRH_RS00860	COG0701	Predicted permease
KRH_RS00880	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KRH_RS00890	COG1063	alcohol dehydrogenase
KRH_RS00905	COG2814	Major facilitator Superfamily
KRH_RS00920	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KRH_RS00935	COG0191	fructose-bisphosphate aldolase activity
KRH_RS00945	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
KRH_RS00955	COG0686	Belongs to the AlaDH PNT family
KRH_RS00960	COG1113	amino acid transport
KRH_RS00970	COG1404	Belongs to the peptidase S8 family
KRH_RS00975	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KRH_RS00980	COG0833	amino acid
KRH_RS01000	COG3590	peptidase
KRH_RS01015	COG1024	Enoyl-CoA hydratase
KRH_RS01020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KRH_RS01025	COG2151	metal-sulfur cluster biosynthetic enzyme
KRH_RS01030	COG3396	Phenylacetate-CoA oxygenase
KRH_RS01035	COG3460	Phenylacetate-CoA oxygenase
KRH_RS01040	COG3396	Phenylacetate-CoA oxygenase
KRH_RS01060	COG0454	-acetyltransferase
KRH_RS01065	COG2030	dehydratase
KRH_RS01065	COG1012	belongs to the aldehyde dehydrogenase family
KRH_RS01070	COG2050	protein possibly involved in aromatic compounds catabolism
KRH_RS01085	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KRH_RS01105	COG1250	3-hydroxyacyl-CoA dehydrogenase
KRH_RS01110	COG1024	Enoyl-CoA hydratase
KRH_RS01115	COG0183	Belongs to the thiolase family
KRH_RS01120	COG0477	Major facilitator Superfamily
KRH_RS01125	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KRH_RS01130	COG1028	Short-chain dehydrogenase reductase Sdr
KRH_RS01135	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KRH_RS01145	COG0183	Belongs to the thiolase family
KRH_RS01160	COG2031	fatty acid transporter
KRH_RS01185	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KRH_RS01190	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KRH_RS01195	COG0156	8-amino-7-oxononanoate synthase activity
KRH_RS01200	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KRH_RS01210	COG2826	transposase and inactivated derivatives, IS30 family
KRH_RS01215	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KRH_RS01215	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KRH_RS01230	COG0129	dihydroxy-acid dehydratase activity
KRH_RS01235	COG1115	amino acid carrier protein
KRH_RS01240	COG3949	Membrane
KRH_RS01250	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KRH_RS01270	COG3415	Transposase
KRH_RS01270	COG2801	Transposase and inactivated derivatives
KRH_RS01280	COG2318	DinB family
KRH_RS01285	COG1063	alcohol dehydrogenase
KRH_RS01290	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KRH_RS01300	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KRH_RS01305	COG0047	phosphoribosylformylglycinamidine synthase activity
KRH_RS01310	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KRH_RS01320	COG2851	Citrate transporter
KRH_RS01325	COG3290	protein histidine kinase activity
KRH_RS01330	COG4565	transcriptional regulatory protein
KRH_RS01345	COG1846	Transcriptional regulator
KRH_RS01355	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KRH_RS01400	COG0351	phosphomethylpyrimidine kinase
KRH_RS01410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KRH_RS01430	COG0343	queuine tRNA-ribosyltransferase activity
KRH_RS01435	COG1414	Transcriptional regulator
KRH_RS01445	COG0477	Major facilitator Superfamily
KRH_RS01460	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
KRH_RS01465	COG0564	pseudouridine synthase activity
KRH_RS01475	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KRH_RS01490	COG1201	RNA secondary structure unwinding
KRH_RS01500	COG0247	lactate metabolic process
KRH_RS01500	COG0277	FAD linked oxidase domain protein
KRH_RS01540	COG0577	efflux transmembrane transporter activity
KRH_RS01545	COG1136	(ABC) transporter
KRH_RS01550	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KRH_RS01580	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
KRH_RS01585	COG1959	2 iron, 2 sulfur cluster binding
KRH_RS01595	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KRH_RS01600	COG1482	cell wall glycoprotein biosynthetic process
KRH_RS01615	COG1254	Belongs to the acylphosphatase family
KRH_RS01635	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KRH_RS01650	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KRH_RS01660	COG0022	dehydrogenase e1 component
KRH_RS01665	COG0508	dehydrogenase complex catalyzes the overall conversion of
KRH_RS01685	COG2197	response regulator
KRH_RS01695	COG0318	PFAM AMP-dependent synthetase and ligase
KRH_RS01700	COG0583	DNA-binding transcription factor activity
KRH_RS01715	COG0435	Glutathione S-transferase
KRH_RS01725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KRH_RS01735	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KRH_RS01740	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KRH_RS01745	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KRH_RS01750	COG0776	regulation of translation
KRH_RS01765	COG2847	Copper chaperone PCu(A)C
KRH_RS01770	COG2837	iron assimilation
KRH_RS01820	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
KRH_RS01830	COG0717	Belongs to the dCTP deaminase family
KRH_RS01840	COG2111	Na H antiporter
KRH_RS01840	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KRH_RS01845	COG1006	Multisubunit Na H antiporter MnhC subunit
KRH_RS01850	COG0651	ATP synthesis coupled electron transport
KRH_RS01860	COG2212	antiporter activity
KRH_RS01865	COG1320	monovalent cation:proton antiporter activity
KRH_RS01875	COG4721	ABC-type cobalt transport system, permease component
KRH_RS01880	COG1122	ATPase activity
KRH_RS01885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KRH_RS01895	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
KRH_RS01900	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KRH_RS01915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KRH_RS01920	COG0443	Heat shock 70 kDa protein
KRH_RS01925	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KRH_RS01930	COG0484	heat shock protein binding
KRH_RS01935	COG0789	Transcriptional regulator
KRH_RS01940	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KRH_RS01945	COG2814	Major facilitator Superfamily
KRH_RS01950	COG1115	amino acid carrier protein
KRH_RS01955	COG1113	amino acid transport
KRH_RS01960	COG0676	glucose-6-phosphate 1-epimerase activity
KRH_RS01965	COG1115	amino acid carrier protein
KRH_RS01980	COG4221	oxidoreductase activity
KRH_RS01995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KRH_RS02015	COG0519	Catalyzes the synthesis of GMP from XMP
KRH_RS02025	COG0542	response to heat
KRH_RS02040	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KRH_RS02065	COG0151	Belongs to the GarS family
KRH_RS02070	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KRH_RS02080	COG4585	Histidine kinase
KRH_RS02090	COG2197	response regulator
KRH_RS02095	COG2186	Transcriptional regulator
KRH_RS02100	COG1620	l-lactate permease
KRH_RS02105	COG0247	lactate metabolic process
KRH_RS02110	COG1139	Iron-sulfur cluster binding protein
KRH_RS02115	COG1556	Lactate utilization protein
KRH_RS02125	COG2022	thiamine diphosphate biosynthetic process
KRH_RS02135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KRH_RS02135	COG2022	thiamine diphosphate biosynthetic process
KRH_RS02140	COG0352	thiamine-phosphate diphosphorylase activity
KRH_RS02150	COG0384	phenazine biosynthesis protein PhzF
KRH_RS02165	COG0247	lactate metabolic process
KRH_RS02165	COG0277	FAD linked oxidase domain protein
KRH_RS02175	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KRH_RS02205	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KRH_RS02210	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KRH_RS02215	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KRH_RS02220	COG0494	nUDIX hydrolase
KRH_RS02230	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KRH_RS02280	COG1111	helicase
KRH_RS02280	COG1205	dead DEAH box helicase
KRH_RS02290	COG2890	protein-(glutamine-N5) methyltransferase activity
KRH_RS02295	COG1754	DNA topoisomerase type I activity
KRH_RS02295	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KRH_RS02300	COG0248	Ppx GppA phosphatase
KRH_RS02305	COG1082	Xylose isomerase domain protein TIM barrel
KRH_RS02310	COG0456	acetyltransferase
KRH_RS02320	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
KRH_RS02330	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KRH_RS02335	COG0123	including yeast histone deacetylase and acetoin utilization protein
KRH_RS02345	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KRH_RS02350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KRH_RS02360	COG0406	alpha-ribazole phosphatase activity
KRH_RS02370	COG0785	Cytochrome C biogenesis protein
KRH_RS02375	COG1333	cytochrome c biogenesis protein
KRH_RS02380	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KRH_RS02410	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KRH_RS02420	COG1643	Atp-dependent helicase
KRH_RS02430	COG0039	L-malate dehydrogenase activity
KRH_RS02435	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KRH_RS02440	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KRH_RS02455	COG1960	acyl-CoA dehydrogenase activity
KRH_RS02465	COG0583	DNA-binding transcription factor activity
KRH_RS02470	COG1250	3-hydroxyacyl-CoA dehydrogenase
KRH_RS02475	COG1024	Enoyl-CoA hydratase
KRH_RS02520	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
KRH_RS02525	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
KRH_RS02555	COG4948	Mandelate Racemase Muconate Lactonizing
KRH_RS02565	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KRH_RS02570	COG0175	sulfate reduction
KRH_RS02585	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
KRH_RS02595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KRH_RS02600	COG1169	isochorismate synthase
KRH_RS02605	COG0644	oxidoreductase
KRH_RS02610	COG0142	geranyltranstransferase activity
KRH_RS02615	COG0733	neurotransmitter:sodium symporter activity
KRH_RS02655	COG0501	Belongs to the peptidase M48B family
KRH_RS02660	COG1666	GTP binding
KRH_RS02675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KRH_RS02710	COG2030	dehydratase
KRH_RS02720	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KRH_RS02730	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KRH_RS02740	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KRH_RS02745	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KRH_RS02750	COG0406	alpha-ribazole phosphatase activity
KRH_RS02750	COG0494	nUDIX hydrolase
KRH_RS02755	COG0456	acetyltransferase
KRH_RS02755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KRH_RS02760	COG0745	RESPONSE REGULATOR receiver
KRH_RS02770	COG3485	protocatechuate 3,4-dioxygenase
KRH_RS02775	COG0354	folic acid binding
KRH_RS02785	COG2326	polyphosphate kinase activity
KRH_RS02805	COG0436	Aminotransferase
KRH_RS02815	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KRH_RS02825	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KRH_RS02830	COG0081	regulation of translation
KRH_RS02860	COG0315	cyclic pyranopterin monophosphate synthase activity
KRH_RS02870	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KRH_RS02875	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KRH_RS02880	COG0222	ribosome binding
KRH_RS02890	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KRH_RS02895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KRH_RS02900	COG0085	RNA polymerase activity
KRH_RS02905	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KRH_RS02915	COG3485	protocatechuate 3,4-dioxygenase
KRH_RS02920	COG3485	protocatechuate 3,4-dioxygenase
KRH_RS02925	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KRH_RS02935	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KRH_RS02945	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KRH_RS02950	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KRH_RS02955	COG0049	tRNA binding
KRH_RS02960	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KRH_RS02965	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KRH_RS02970	COG0051	transcription antitermination factor activity, RNA binding
KRH_RS02975	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KRH_RS02980	COG0088	Forms part of the polypeptide exit tunnel
KRH_RS02985	COG0089	rRNA binding
KRH_RS02990	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KRH_RS02995	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KRH_RS03000	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KRH_RS03005	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KRH_RS03010	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KRH_RS03015	COG0255	Belongs to the universal ribosomal protein uL29 family
KRH_RS03020	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KRH_RS03025	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KRH_RS03030	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KRH_RS03035	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KRH_RS03040	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KRH_RS03045	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KRH_RS03050	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KRH_RS03055	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KRH_RS03060	COG1841	ribosomal large subunit assembly
KRH_RS03065	COG0200	Binds to the 23S rRNA
KRH_RS03075	COG0563	adenylate kinase activity
KRH_RS03085	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KRH_RS03090	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KRH_RS03095	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KRH_RS03100	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KRH_RS03105	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KRH_RS03110	COG0202	RNA polymerase activity
KRH_RS03115	COG0203	ribosomal protein L17
KRH_RS03120	COG0101	tRNA pseudouridine synthase activity
KRH_RS03125	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KRH_RS03130	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KRH_RS03135	COG2326	polyphosphate kinase activity
KRH_RS03140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KRH_RS03145	COG1970	mechanosensitive ion channel activity
KRH_RS03150	COG1072	(Pantothenic acid kinase))
KRH_RS03160	COG0736	holo-[acyl-carrier-protein] synthase activity
KRH_RS03185	COG0667	Aldo Keto reductase
KRH_RS03195	COG1260	myo-inositol-1-phosphate synthase
KRH_RS03205	COG0438	transferase activity, transferring glycosyl groups
KRH_RS03215	COG0813	purine-nucleoside phosphorylase activity
KRH_RS03225	COG1214	PFAM Peptidase M22, glycoprotease
KRH_RS03225	COG0456	acetyltransferase
KRH_RS03235	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KRH_RS03240	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
KRH_RS03270	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KRH_RS03275	COG0459	protein refolding
KRH_RS03280	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KRH_RS03280	COG2755	lipolytic protein G-D-S-L family
KRH_RS03290	COG0516	GMP reductase activity
KRH_RS03305	COG0519	Catalyzes the synthesis of GMP from XMP
KRH_RS03305	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KRH_RS03330	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KRH_RS03335	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KRH_RS03370	COG1216	Glycosyl transferase, family 2
KRH_RS03385	COG1473	amidohydrolase
KRH_RS03405	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
KRH_RS03420	COG0668	transmembrane transport
KRH_RS03425	COG0598	Magnesium transport protein CorA
KRH_RS03430	COG2816	NAD+ diphosphatase activity
KRH_RS03445	COG1722	exodeoxyribonuclease VII activity
KRH_RS03450	COG1570	exodeoxyribonuclease VII activity
KRH_RS03460	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KRH_RS03465	COG1322	Protein conserved in bacteria
KRH_RS03470	COG2197	response regulator
KRH_RS03475	COG4585	Histidine kinase
KRH_RS03485	COG1131	(ABC) transporter
KRH_RS03490	COG0012	GTP binding
KRH_RS03520	COG2801	Transposase and inactivated derivatives
KRH_RS03520	COG3415	Transposase
KRH_RS03615	COG1401	restriction endodeoxyribonuclease activity
KRH_RS03620	COG0471	metal ion transport
KRH_RS03625	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KRH_RS03630	COG1053	succinate dehydrogenase
KRH_RS03645	COG1620	l-lactate permease
KRH_RS03685	COG0584	glycerophosphoryl diester phosphodiesterase
KRH_RS03710	COG3424	synthase
KRH_RS03715	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KRH_RS03720	COG0778	Nitroreductase
KRH_RS03750	COG3383	formate dehydrogenase (NAD+) activity
KRH_RS03750	COG0243	molybdopterin cofactor binding
KRH_RS03760	COG0437	4 iron, 4 sulfur cluster binding
KRH_RS03770	COG0709	Synthesizes selenophosphate from selenide and ATP
KRH_RS03780	COG1921	L-seryl-tRNASec selenium transferase activity
KRH_RS03800	COG0596	Alpha beta hydrolase
KRH_RS03805	COG5006	permease, DMT superfamily
KRH_RS03825	COG0456	acetyltransferase
KRH_RS03835	COG1054	Belongs to the UPF0176 family
KRH_RS03840	COG2258	MOSC domain
KRH_RS03850	COG3012	SEC-C Motif Domain Protein
KRH_RS03855	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
KRH_RS03865	COG0039	L-malate dehydrogenase activity
KRH_RS03870	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KRH_RS03875	COG2838	Isocitrate dehydrogenase
KRH_RS03885	COG0747	negative chemotaxis
KRH_RS03920	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KRH_RS03925	COG0154	amidase activity
KRH_RS03930	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KRH_RS03955	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
KRH_RS03960	COG1506	peptidase
KRH_RS03960	COG0823	Involved in the tonB-independent uptake of proteins
KRH_RS03965	COG1217	gtp-binding protein TYPA
KRH_RS03970	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KRH_RS03995	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KRH_RS04000	COG2171	N-acyltransferase activity
KRH_RS04005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KRH_RS04010	COG1611	Belongs to the LOG family
KRH_RS04020	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KRH_RS04025	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KRH_RS04030	COG4122	O-methyltransferase activity
KRH_RS04055	COG2239	Acts as a magnesium transporter
KRH_RS04065	COG0006	proline dipeptidase activity
KRH_RS04075	COG2189	Belongs to the N(4) N(6)-methyltransferase family
KRH_RS04080	COG0513	Belongs to the DEAD box helicase family
KRH_RS04090	COG1309	transcriptional regulator
KRH_RS04095	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KRH_RS04100	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KRH_RS04115	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KRH_RS04120	COG0181	hydroxymethylbilane synthase activity
KRH_RS04130	COG0113	porphobilinogen synthase activity
KRH_RS04135	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KRH_RS04200	COG3480	Lon protease (S16) C-terminal proteolytic domain
KRH_RS04205	COG1615	UPF0182 protein
KRH_RS04215	COG0433	COG0433 Predicted ATPase
KRH_RS04220	COG1842	Phage shock protein A
KRH_RS04230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KRH_RS04235	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KRH_RS04245	COG0482	sulfurtransferase activity
KRH_RS04250	COG0287	Prephenate dehydrogenase
KRH_RS04250	COG1605	Chorismate mutase
KRH_RS04260	COG0745	RESPONSE REGULATOR receiver
KRH_RS04265	COG5000	phosphorelay sensor kinase activity
KRH_RS04265	COG5002	protein histidine kinase activity
KRH_RS04270	COG5401	PFAM Sporulation and spore germination
KRH_RS04275	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KRH_RS04280	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KRH_RS04285	COG0653	protein targeting
KRH_RS04335	COG1674	ftsk spoiiie
KRH_RS04350	COG1216	Glycosyl transferase, family 2
KRH_RS04370	COG0463	Glycosyl transferase, family 2
KRH_RS04505	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KRH_RS04510	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
KRH_RS04515	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KRH_RS04520	COG0488	(ABC) transporter
KRH_RS04530	COG0483	inositol monophosphate 1-phosphatase activity
KRH_RS04540	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KRH_RS04550	COG1595	DNA-templated transcription, initiation
KRH_RS04565	COG0508	dehydrogenase complex catalyzes the overall conversion of
KRH_RS04565	COG0567	Dehydrogenase, E1 component
KRH_RS04575	COG0803	Belongs to the bacterial solute-binding protein 9 family
KRH_RS04580	COG1121	(ABC) transporter
KRH_RS04585	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KRH_RS04610	COG1643	Atp-dependent helicase
KRH_RS04625	COG1116	anion transmembrane transporter activity
KRH_RS04650	COG0018	arginyl-trna synthetase
KRH_RS04660	COG0460	homoserine dehydrogenase
KRH_RS04665	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KRH_RS04670	COG0083	homoserine kinase activity
KRH_RS04680	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KRH_RS04710	COG1086	Polysaccharide biosynthesis protein
KRH_RS04715	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KRH_RS04730	COG0356	it plays a direct role in the translocation of protons across the membrane
KRH_RS04735	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KRH_RS04740	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KRH_RS04745	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KRH_RS04750	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KRH_RS04755	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KRH_RS04760	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KRH_RS04765	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KRH_RS04770	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KRH_RS04780	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
KRH_RS04815	COG1335	isochorismatase
KRH_RS04825	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
KRH_RS04835	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KRH_RS04845	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KRH_RS04850	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KRH_RS04875	COG0420	3'-5' exonuclease activity
KRH_RS04880	COG0419	ATPase involved in DNA repair
KRH_RS04890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KRH_RS04900	COG1295	ribonuclease BN
KRH_RS04905	COG1846	Transcriptional regulator
KRH_RS04910	COG0579	oxidoreductase
KRH_RS04955	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KRH_RS04965	COG0473	3-isopropylmalate dehydrogenase activity
KRH_RS04970	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KRH_RS04975	COG0179	Fumarylacetoacetate (FAA) hydrolase
KRH_RS04980	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KRH_RS05005	COG1414	Transcriptional regulator
KRH_RS05010	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KRH_RS05015	COG0066	3-isopropylmalate dehydratase activity
KRH_RS05020	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KRH_RS05030	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KRH_RS05035	COG1181	Belongs to the D-alanine--D-alanine ligase family
KRH_RS05050	COG1461	Dihydroxyacetone kinase
KRH_RS05060	COG0742	ribosomal rna small subunit methyltransferase
KRH_RS05070	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KRH_RS05080	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KRH_RS05085	COG0571	ribonuclease III activity
KRH_RS05090	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KRH_RS05100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KRH_RS05105	COG0318	PFAM AMP-dependent synthetase and ligase
KRH_RS05110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KRH_RS05115	COG1196	nuclear chromosome segregation
KRH_RS05125	COG0477	Major facilitator Superfamily
KRH_RS05160	COG0228	four-way junction DNA binding
KRH_RS05165	COG1837	Belongs to the UPF0109 family
KRH_RS05170	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KRH_RS05175	COG0336	Belongs to the RNA methyltransferase TrmD family
KRH_RS05180	COG0335	large ribosomal subunit rRNA binding
KRH_RS05195	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KRH_RS05200	COG0792	nuclease activity
KRH_RS05235	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KRH_RS05240	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KRH_RS05255	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
KRH_RS05285	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KRH_RS05290	COG0174	glutamine synthetase
KRH_RS05295	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
KRH_RS05310	COG0629	single-stranded DNA binding
KRH_RS05330	COG3486	L-lysine 6-monooxygenase (NADPH) activity
KRH_RS05345	COG2223	nitrite transmembrane transporter activity
KRH_RS05350	COG1946	Acyl-CoA thioesterase
KRH_RS05375	COG0698	ribose 5-phosphate isomerase
KRH_RS05395	COG0544	peptidyl-prolyl cis-trans isomerase activity
KRH_RS05400	COG0740	serine-type endopeptidase activity
KRH_RS05405	COG0740	serine-type endopeptidase activity
KRH_RS05410	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KRH_RS05415	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KRH_RS05430	COG0525	valine-tRNA ligase activity
KRH_RS05445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KRH_RS05450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KRH_RS05455	COG1120	ATPase activity
KRH_RS05465	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KRH_RS05465	COG1648	precorrin-2 dehydrogenase activity
KRH_RS05470	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KRH_RS05475	COG0285	dihydrofolate synthase activity
KRH_RS05485	COG0105	UTP biosynthetic process
KRH_RS05495	COG1530	ribonuclease E activity
KRH_RS05500	COG0351	phosphomethylpyrimidine kinase
KRH_RS05500	COG0352	thiamine-phosphate diphosphorylase activity
KRH_RS05500	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KRH_RS05505	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KRH_RS05510	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KRH_RS05515	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KRH_RS05520	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KRH_RS05525	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KRH_RS05535	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KRH_RS05545	COG0799	negative regulation of ribosome biogenesis
KRH_RS05600	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KRH_RS05615	COG2837	iron assimilation
KRH_RS05630	COG0587	DNA-directed DNA polymerase activity
KRH_RS05645	COG1780	Probably involved in ribonucleotide reductase function
KRH_RS05650	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KRH_RS05655	COG2423	ornithine cyclodeaminase activity
KRH_RS05690	COG0242	peptide deformylase activity
KRH_RS05695	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KRH_RS05705	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KRH_RS05710	COG3201	nicotinamide mononucleotide transporter
KRH_RS05730	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KRH_RS05730	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KRH_RS05735	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KRH_RS05740	COG0140	phosphoribosyl-ATP diphosphatase activity
KRH_RS05745	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KRH_RS05750	COG0107	imidazoleglycerol-phosphate synthase activity
KRH_RS05755	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KRH_RS05775	COG0133	tryptophan synthase activity
KRH_RS05780	COG0159	tryptophan synthase activity
KRH_RS05785	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KRH_RS05790	COG0067	glutamate synthase
KRH_RS05790	COG0070	glutamate synthase
KRH_RS05790	COG0069	glutamate synthase activity
KRH_RS05800	COG0469	pyruvate kinase activity
KRH_RS05820	COG4552	Acetyltransferase involved in intracellular survival and related
KRH_RS05825	COG0539	negative regulation of cytoplasmic translation
KRH_RS05830	COG1739	Uncharacterized protein family UPF0029
KRH_RS05835	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KRH_RS05840	COG0237	dephospho-CoA kinase activity
KRH_RS05840	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KRH_RS05845	COG0556	nucleotide-excision repair
KRH_RS05875	COG0385	Bile acid
KRH_RS05900	COG0546	phosphoglycolate phosphatase activity
KRH_RS05905	COG0204	Acyl-transferase
KRH_RS05905	COG0318	PFAM AMP-dependent synthetase and ligase
KRH_RS05910	COG0322	excinuclease ABC activity
KRH_RS05915	COG1660	Displays ATPase and GTPase activities
KRH_RS05920	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KRH_RS05925	COG1481	regulation of sporulation
KRH_RS05930	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KRH_RS05935	COG0126	phosphoglycerate kinase activity
KRH_RS05940	COG0149	triose-phosphate isomerase activity
KRH_RS05945	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KRH_RS05950	COG0363	glucosamine-6-phosphate deaminase activity
KRH_RS05970	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KRH_RS05980	COG0109	protoheme IX farnesyltransferase activity
KRH_RS05985	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KRH_RS06000	COG1131	(ABC) transporter
KRH_RS06020	COG0396	ATPase activity
KRH_RS06025	COG2151	metal-sulfur cluster biosynthetic enzyme
KRH_RS06040	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KRH_RS06045	COG1122	ATPase activity
KRH_RS06050	COG1268	BioY protein
KRH_RS06055	COG0488	(ABC) transporter
KRH_RS06080	COG1028	Short-chain dehydrogenase reductase Sdr
KRH_RS06085	COG1028	Short-chain dehydrogenase reductase Sdr
KRH_RS06100	COG2409	Drug exporters of the RND superfamily
KRH_RS06110	COG1119	ATPase activity
KRH_RS06125	COG1404	Belongs to the peptidase S8 family
KRH_RS06130	COG0254	rRNA binding
KRH_RS06140	COG1316	TRANSCRIPTIONal
KRH_RS06150	COG0438	transferase activity, transferring glycosyl groups
KRH_RS06160	COG1134	teichoic acid transport
KRH_RS06170	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KRH_RS06200	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KRH_RS06205	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KRH_RS06215	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KRH_RS06230	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KRH_RS06235	COG0297	glycogen (starch) synthase activity
KRH_RS06265	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KRH_RS06270	COG1845	cytochrome c oxidase, subunit III
KRH_RS06275	COG2010	Cytochrome c
KRH_RS06280	COG0723	plastoquinol--plastocyanin reductase activity
KRH_RS06285	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KRH_RS06295	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KRH_RS06300	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KRH_RS06320	COG0167	dihydroorotate dehydrogenase activity
KRH_RS06325	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KRH_RS06330	COG1381	Involved in DNA repair and RecF pathway recombination
KRH_RS06335	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KRH_RS06340	COG1316	TRANSCRIPTIONal
KRH_RS06345	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KRH_RS06350	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KRH_RS06370	COG0484	heat shock protein binding
KRH_RS06375	COG1420	regulation of RNA biosynthetic process
KRH_RS06395	COG0481	GTPase activity
KRH_RS06405	COG0268	Binds directly to 16S ribosomal RNA
KRH_RS06415	COG1902	pentaerythritol trinitrate reductase activity
KRH_RS06445	COG0495	leucyl-tRNA aminoacylation
KRH_RS06465	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KRH_RS06485	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KRH_RS06490	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KRH_RS06500	COG1758	RNA polymerase activity
KRH_RS06505	COG0194	GDP metabolic process
KRH_RS06510	COG0194	GDP metabolic process
KRH_RS06515	COG0284	orotidine-5'-phosphate decarboxylase activity
KRH_RS06520	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KRH_RS06535	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KRH_RS06540	COG0540	Belongs to the ATCase OTCase family
KRH_RS06545	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
KRH_RS06550	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KRH_RS06555	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KRH_RS06560	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KRH_RS06570	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KRH_RS06585	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KRH_RS06590	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KRH_RS06605	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KRH_RS06610	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KRH_RS06615	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KRH_RS06620	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KRH_RS06630	COG1490	D-aminoacyl-tRNA deacylase activity
KRH_RS06635	COG2807	transmembrane transport
KRH_RS06640	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KRH_RS06645	COG0124	histidyl-tRNA synthetase
KRH_RS06650	COG1196	nuclear chromosome segregation
KRH_RS06660	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KRH_RS06665	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KRH_RS06670	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KRH_RS06680	COG2255	four-way junction helicase activity
KRH_RS06685	COG0632	four-way junction helicase activity
KRH_RS06690	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
KRH_RS06695	COG0217	transcriptional regulatory protein
KRH_RS06705	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KRH_RS06715	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KRH_RS06720	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
KRH_RS06740	COG1216	Glycosyl transferase, family 2
KRH_RS06750	COG4581	dead DEAH box helicase
KRH_RS06755	COG0805	protein transport
KRH_RS06760	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KRH_RS06780	COG0545	Peptidyl-prolyl cis-trans isomerase
KRH_RS06785	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
KRH_RS06795	COG4122	O-methyltransferase activity
KRH_RS06800	COG1222	aaa ATPase
KRH_RS06810	COG0517	IMP dehydrogenase activity
KRH_RS06810	COG1994	Peptidase M50
KRH_RS06820	COG0215	cysteine-tRNA ligase activity
KRH_RS06825	COG1968	undecaprenyl-diphosphatase activity
KRH_RS06845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KRH_RS06875	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KRH_RS06900	COG2267	carboxylic ester hydrolase activity
KRH_RS06905	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KRH_RS06930	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KRH_RS06935	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KRH_RS06940	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KRH_RS06945	COG0531	amino acid
KRH_RS06950	COG0569	domain protein
KRH_RS06970	COG0756	dUTP diphosphatase activity
KRH_RS07015	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KRH_RS07030	COG2226	methyltransferase
KRH_RS07035	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KRH_RS07045	COG2223	nitrite transmembrane transporter activity
KRH_RS07055	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KRH_RS07060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KRH_RS07065	COG0508	dehydrogenase complex catalyzes the overall conversion of
KRH_RS07080	COG0321	lipoyl(octanoyl) transferase activity
KRH_RS07085	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KRH_RS07110	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
KRH_RS07125	COG1028	Short-chain dehydrogenase reductase Sdr
KRH_RS07160	COG3022	response to hydroperoxide
KRH_RS07170	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KRH_RS07175	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KRH_RS07185	COG1045	serine acetyltransferase
KRH_RS07190	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KRH_RS07210	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KRH_RS07215	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KRH_RS07220	COG0587	DNA-directed DNA polymerase activity
KRH_RS07230	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KRH_RS07245	COG1799	cell septum assembly
KRH_RS07250	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KRH_RS07260	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KRH_RS07270	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KRH_RS07275	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KRH_RS07285	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KRH_RS07290	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KRH_RS07295	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KRH_RS07305	COG0768	penicillin binding
KRH_RS07315	COG0275	rRNA processing
KRH_RS07320	COG2001	Belongs to the MraZ family
KRH_RS07330	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KRH_RS07335	COG0142	geranyltranstransferase activity
KRH_RS07345	COG1388	LysM domain
KRH_RS07345	COG0791	NLP P60 protein
KRH_RS07350	COG2815	serine threonine protein kinase
KRH_RS07350	COG0515	serine threonine protein kinase
KRH_RS07355	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
KRH_RS07410	COG1716	ATPase activity
KRH_RS07415	COG0509	glycine decarboxylation via glycine cleavage system
KRH_RS07420	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KRH_RS07425	COG0569	domain protein
KRH_RS07430	COG0523	cobalamin synthesis protein
KRH_RS07440	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
KRH_RS07455	COG0390	transport system, permease component
KRH_RS07465	COG1160	GTP binding
KRH_RS07470	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KRH_RS07485	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KRH_RS07490	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KRH_RS07500	COG1301	dicarboxylic acid transport
KRH_RS07515	COG2079	MmgE PrpD family protein
KRH_RS07520	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
KRH_RS07540	COG0494	nUDIX hydrolase
KRH_RS07545	COG0504	CTP synthase activity
KRH_RS07550	COG0497	DNA recombination
KRH_RS07555	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KRH_RS07570	COG0647	UMP catabolic process
KRH_RS07600	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KRH_RS07610	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KRH_RS07615	COG2094	Belongs to the DNA glycosylase MPG family
KRH_RS07620	COG0165	Argininosuccinate lyase
KRH_RS07625	COG0137	argininosuccinate synthase activity
KRH_RS07630	COG0318	PFAM AMP-dependent synthetase and ligase
KRH_RS07640	COG1438	arginine binding
KRH_RS07645	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KRH_RS07655	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KRH_RS07660	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KRH_RS07665	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KRH_RS07680	COG0072	phenylalanine-tRNA ligase activity
KRH_RS07680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KRH_RS07685	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KRH_RS07695	COG0494	nUDIX hydrolase
KRH_RS07700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KRH_RS07705	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KRH_RS07710	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KRH_RS07715	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KRH_RS07730	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KRH_RS07735	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KRH_RS07740	COG0131	Imidazoleglycerol-phosphate dehydratase
KRH_RS07745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KRH_RS07755	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KRH_RS07765	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KRH_RS07770	COG2813	Specifically methylates the guanine in position
KRH_RS07775	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KRH_RS07780	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KRH_RS07785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KRH_RS07790	COG2137	regulation of response to DNA damage stimulus
KRH_RS07795	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KRH_RS07805	COG1396	sequence-specific DNA binding
KRH_RS07820	COG1674	ftsk spoiiie
KRH_RS07825	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KRH_RS07830	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KRH_RS07840	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KRH_RS07845	COG0612	Peptidase, M16
KRH_RS07850	COG1185	polyribonucleotide nucleotidyltransferase activity
KRH_RS07855	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KRH_RS07885	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KRH_RS07890	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KRH_RS07895	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KRH_RS07910	COG0779	Required for maturation of 30S ribosomal subunits
KRH_RS07925	COG0442	prolyl-tRNA aminoacylation
KRH_RS07935	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KRH_RS07940	COG2011	ABC-type metal ion transport system permease component
KRH_RS07945	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KRH_RS07950	COG1464	Belongs to the NlpA lipoprotein family
KRH_RS07955	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KRH_RS07960	COG2261	transglycosylase associated protein
KRH_RS07965	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KRH_RS07980	COG0575	Belongs to the CDS family
KRH_RS07985	COG0233	cytoplasmic translational termination
KRH_RS07990	COG0528	UMP kinase activity
KRH_RS07995	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KRH_RS08000	COG0052	Belongs to the universal ribosomal protein uS2 family
KRH_RS08030	COG1136	(ABC) transporter
KRH_RS08040	COG4585	Histidine kinase
KRH_RS08045	COG2197	response regulator
KRH_RS08050	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KRH_RS08095	COG0358	DNA primase activity
KRH_RS08115	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
KRH_RS08120	COG2814	Major facilitator Superfamily
KRH_RS08130	COG0423	glycine-tRNA ligase activity
KRH_RS08135	COG1960	acyl-CoA dehydrogenase activity
KRH_RS08165	COG2755	lipolytic protein G-D-S-L family
KRH_RS08175	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KRH_RS08180	COG2873	o-acetylhomoserine
KRH_RS08195	COG4585	Histidine kinase
KRH_RS08200	COG2197	response regulator
KRH_RS08205	COG4152	abc transporter atp-binding protein
KRH_RS08230	COG1388	LysM domain
KRH_RS08240	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KRH_RS08245	COG2030	dehydratase
KRH_RS08250	COG1028	Short-chain dehydrogenase reductase Sdr
KRH_RS08255	COG0183	Belongs to the thiolase family
KRH_RS08270	COG0631	protein serine/threonine phosphatase activity
KRH_RS08285	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
KRH_RS08285	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
KRH_RS08295	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KRH_RS08315	COG1301	dicarboxylic acid transport
KRH_RS08345	COG0702	epimerase
KRH_RS08355	COG0424	maF-like protein
KRH_RS08360	COG4770	biotin carboxylase activity
KRH_RS08365	COG0477	Major facilitator Superfamily
KRH_RS08410	COG1216	Glycosyl transferase, family 2
KRH_RS08445	COG0438	transferase activity, transferring glycosyl groups
KRH_RS08455	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KRH_RS08460	COG0193	aminoacyl-tRNA hydrolase activity
KRH_RS08465	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KRH_RS08470	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KRH_RS08480	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KRH_RS08485	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KRH_RS08500	COG0488	(ABC) transporter
KRH_RS08530	COG0531	amino acid
KRH_RS08535	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
KRH_RS08540	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KRH_RS08545	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KRH_RS08550	COG0084	hydrolase, TatD family'
KRH_RS08555	COG0714	Associated with various cellular activities
KRH_RS08625	COG0300	oxidoreductase activity
KRH_RS08645	COG0288	reversible hydration of carbon dioxide
KRH_RS08650	COG0114	fumarate hydratase activity
KRH_RS08655	COG0028	Belongs to the TPP enzyme family
KRH_RS08675	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KRH_RS08680	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KRH_RS08690	COG1331	Highly conserved protein containing a thioredoxin domain
KRH_RS08700	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KRH_RS08710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KRH_RS08720	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KRH_RS08770	COG0148	phosphopyruvate hydratase activity
KRH_RS08775	COG3956	TIGRFAM MazG family protein
KRH_RS08780	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KRH_RS08795	COG1744	ABC transporter substrate-binding protein PnrA-like
KRH_RS08800	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
KRH_RS08800	COG1473	amidohydrolase
KRH_RS08810	COG2009	succinate dehydrogenase
KRH_RS08820	COG1053	succinate dehydrogenase
KRH_RS08825	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KRH_RS08840	COG0180	Tryptophanyl-tRNA synthetase
KRH_RS08855	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KRH_RS08860	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KRH_RS08875	COG0138	bifunctional purine biosynthesis protein purh
KRH_RS08895	COG0438	transferase activity, transferring glycosyl groups
KRH_RS08910	COG1012	belongs to the aldehyde dehydrogenase family
KRH_RS08915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KRH_RS08925	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KRH_RS08945	COG0045	succinate-CoA ligase (ADP-forming) activity
KRH_RS08995	COG1321	iron dependent repressor
KRH_RS09000	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
KRH_RS09005	COG2814	Major facilitator Superfamily
KRH_RS09025	COG0745	RESPONSE REGULATOR receiver
KRH_RS09030	COG2205	protein histidine kinase activity
KRH_RS09040	COG0328	RNA-DNA hybrid ribonuclease activity
KRH_RS09045	COG0459	protein refolding
KRH_RS09060	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KRH_RS09080	COG0069	glutamate synthase activity
KRH_RS09090	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KRH_RS09105	COG1349	DNA-binding transcription factor activity
KRH_RS09135	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
KRH_RS09160	COG1028	Short-chain dehydrogenase reductase Sdr
KRH_RS09170	COG0277	FAD linked oxidase domain protein
KRH_RS09175	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KRH_RS09195	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KRH_RS09205	COG0366	Alpha amylase catalytic
KRH_RS09220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KRH_RS09225	COG0215	cysteine-tRNA ligase activity
KRH_RS09230	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KRH_RS09235	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KRH_RS09255	COG5002	protein histidine kinase activity
KRH_RS09260	COG0704	Plays a role in the regulation of phosphate uptake
KRH_RS09265	COG0588	phosphoglycerate mutase activity
KRH_RS09285	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KRH_RS09290	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KRH_RS09320	COG1966	Carbon starvation protein
KRH_RS09335	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KRH_RS09340	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KRH_RS09350	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KRH_RS09355	COG2390	Transcriptional regulator
KRH_RS09365	COG1404	Belongs to the peptidase S8 family
KRH_RS09390	COG0514	ATP-dependent DNA helicase (RecQ)
KRH_RS09420	COG0306	phosphate transporter
KRH_RS09425	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KRH_RS09445	COG4129	membrane
KRH_RS09455	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
KRH_RS09470	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
KRH_RS09490	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KRH_RS09520	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KRH_RS09535	COG0302	gtp cyclohydrolase
KRH_RS09540	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KRH_RS09550	COG0037	tRNA processing
KRH_RS09565	COG2027	D-alanyl-D-alanine carboxypeptidase
KRH_RS09570	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KRH_RS09585	COG0561	phosphatase activity
KRH_RS09590	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KRH_RS09610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KRH_RS09615	COG1113	amino acid transport
KRH_RS09625	COG0028	Belongs to the TPP enzyme family
KRH_RS09635	COG1012	belongs to the aldehyde dehydrogenase family
KRH_RS09650	COG1113	amino acid transport
KRH_RS09655	COG0154	amidase activity
KRH_RS09680	COG1321	iron dependent repressor
KRH_RS09685	COG1250	3-hydroxyacyl-CoA dehydrogenase
KRH_RS09690	COG2233	PERMEase
KRH_RS09715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KRH_RS09720	COG0601	transmembrane transport
KRH_RS09730	COG0584	glycerophosphoryl diester phosphodiesterase
KRH_RS09735	COG0561	phosphatase activity
KRH_RS09755	COG1362	aminopeptidase activity
KRH_RS09760	COG1266	CAAX protease self-immunity
KRH_RS09775	COG2351	hydroxyisourate hydrolase activity
KRH_RS09785	COG2233	PERMEase
KRH_RS09795	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KRH_RS09805	COG3257	ureidoglycine aminohydrolase activity
KRH_RS09810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KRH_RS09820	COG1064	alcohol dehydrogenase
KRH_RS09825	COG3622	Belongs to the hyi family
KRH_RS09830	COG1929	Belongs to the glycerate kinase type-1 family
KRH_RS09835	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KRH_RS09845	COG2514	catechol 2,3-dioxygenase activity
KRH_RS09850	COG0667	Aldo Keto reductase
KRH_RS09875	COG2814	Major facilitator Superfamily
KRH_RS09890	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KRH_RS09900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KRH_RS09925	COG2902	Dehydrogenase
KRH_RS09935	COG0406	alpha-ribazole phosphatase activity
KRH_RS09950	COG0667	Aldo Keto reductase
KRH_RS09980	COG1522	sequence-specific DNA binding
KRH_RS09985	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KRH_RS09990	COG1113	amino acid transport
KRH_RS10010	COG2354	Protein conserved in bacteria
KRH_RS10030	COG2271	Major facilitator Superfamily
KRH_RS10040	COG2814	Major facilitator Superfamily
KRH_RS10050	COG3265	gluconokinase activity
KRH_RS10055	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KRH_RS10085	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KRH_RS10095	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KRH_RS10100	COG0736	holo-[acyl-carrier-protein] synthase activity
KRH_RS10115	COG0297	glycogen (starch) synthase activity
KRH_RS10120	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
KRH_RS10125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KRH_RS10165	COG0438	transferase activity, transferring glycosyl groups
KRH_RS10170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KRH_RS10175	COG0471	metal ion transport
KRH_RS10180	COG0783	Belongs to the Dps family
KRH_RS10185	COG0446	pyridine nucleotide-disulphide oxidoreductase
KRH_RS10185	COG1902	pentaerythritol trinitrate reductase activity
KRH_RS10190	COG1716	ATPase activity
KRH_RS10195	COG1716	ATPase activity
KRH_RS10210	COG0768	penicillin binding
KRH_RS10215	COG0515	serine threonine protein kinase
KRH_RS10220	COG0515	serine threonine protein kinase
KRH_RS10240	COG2353	YceI-like domain
KRH_RS10260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KRH_RS10265	COG2267	carboxylic ester hydrolase activity
KRH_RS10275	COG1131	(ABC) transporter
KRH_RS10280	COG1725	Transcriptional regulator
KRH_RS10310	COG0142	geranyltranstransferase activity
KRH_RS10320	COG3001	Fructosamine kinase
KRH_RS10340	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KRH_RS10370	COG0318	PFAM AMP-dependent synthetase and ligase
KRH_RS10375	COG1960	acyl-CoA dehydrogenase activity
KRH_RS10380	COG1024	Enoyl-CoA hydratase
KRH_RS10380	COG1250	3-hydroxyacyl-CoA dehydrogenase
KRH_RS10390	COG0747	negative chemotaxis
KRH_RS10395	COG0601	transmembrane transport
KRH_RS10400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KRH_RS10415	COG1607	acyl-coa hydrolase
KRH_RS10420	COG0477	Major facilitator Superfamily
KRH_RS10435	COG0456	acetyltransferase
KRH_RS10440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KRH_RS10455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KRH_RS10460	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
KRH_RS10465	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
KRH_RS10470	COG4770	biotin carboxylase activity
KRH_RS10480	COG4336	lyase activity
KRH_RS10510	COG0702	epimerase
KRH_RS10515	COG1522	sequence-specific DNA binding
KRH_RS10525	COG0022	dehydrogenase e1 component
KRH_RS10530	COG0508	dehydrogenase complex catalyzes the overall conversion of
KRH_RS10545	COG0778	Nitroreductase
KRH_RS10565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KRH_RS10590	COG2233	PERMEase
KRH_RS10595	COG0590	tRNA wobble adenosine to inosine editing
KRH_RS10605	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KRH_RS10610	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
KRH_RS10645	COG2267	carboxylic ester hydrolase activity
KRH_RS10650	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KRH_RS10650	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
KRH_RS10690	COG0739	heme binding
KRH_RS10705	COG1012	belongs to the aldehyde dehydrogenase family
KRH_RS10715	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
KRH_RS10720	COG0829	nickel cation binding
KRH_RS10725	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
KRH_RS10730	COG0830	nickel cation binding
KRH_RS10735	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
KRH_RS10740	COG0804	urea catabolic process
KRH_RS10745	COG0832	Belongs to the urease beta subunit family
KRH_RS10750	COG0831	urea catabolic process
KRH_RS10755	COG0477	Major facilitator Superfamily
KRH_RS10770	COG1136	(ABC) transporter
KRH_RS10770	COG0577	efflux transmembrane transporter activity
KRH_RS10775	COG2197	response regulator
KRH_RS10780	COG4585	Histidine kinase
KRH_RS10795	COG1253	flavin adenine dinucleotide binding
KRH_RS10805	COG0673	inositol 2-dehydrogenase activity
KRH_RS10890	COG3971	2-oxopent-4-enoate hydratase activity
KRH_RS10900	COG1012	belongs to the aldehyde dehydrogenase family
KRH_RS10910	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KRH_RS10925	COG2837	iron assimilation
KRH_RS10930	COG2076	Multidrug Resistance protein
KRH_RS10955	COG0494	nUDIX hydrolase
KRH_RS10965	COG0477	Major facilitator Superfamily
KRH_RS10970	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KRH_RS11000	COG4589	Belongs to the CDS family
KRH_RS11015	COG2409	Drug exporters of the RND superfamily
KRH_RS11025	COG3048	D-serine ammonia-lyase activity
KRH_RS11040	COG1278	Cold shock
KRH_RS11045	COG1902	pentaerythritol trinitrate reductase activity
KRH_RS11050	COG1012	belongs to the aldehyde dehydrogenase family
KRH_RS11070	COG2050	protein possibly involved in aromatic compounds catabolism
KRH_RS11075	COG1028	Short-chain dehydrogenase reductase Sdr
KRH_RS11080	COG1574	metal-dependent hydrolase with the TIM-barrel fold
KRH_RS11085	COG0477	Major facilitator Superfamily
KRH_RS11100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KRH_RS11105	COG0586	Pfam SNARE associated Golgi protein
KRH_RS11125	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KRH_RS11125	COG2169	Transcriptional regulator
KRH_RS11130	COG1216	Glycosyl transferase, family 2
KRH_RS11145	COG1764	response to oxidative stress
KRH_RS11150	COG1063	alcohol dehydrogenase
KRH_RS11175	COG2720	vancomycin resistance protein
KRH_RS11200	COG0730	response to heat
KRH_RS11215	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KRH_RS11235	COG1960	acyl-CoA dehydrogenase activity
KRH_RS11245	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KRH_RS11250	COG1309	transcriptional regulator
KRH_RS11260	COG0318	PFAM AMP-dependent synthetase and ligase
KRH_RS11265	COG3311	Transcriptional regulator
KRH_RS11285	COG0415	Belongs to the DNA photolyase family
KRH_RS11290	COG0814	amino acid
KRH_RS11295	COG1846	Transcriptional regulator
KRH_RS11300	COG4716	Myosin-crossreactive antigen
KRH_RS11330	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
KRH_RS11335	COG1228	amidohydrolase
KRH_RS11340	COG3314	Sporulation integral membrane protein YlbJ
KRH_RS11360	COG0596	Alpha beta hydrolase
KRH_RS11390	COG0477	Major facilitator Superfamily
KRH_RS11395	COG2391	methyltransferase activity
KRH_RS11415	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KRH_RS11415	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KRH_RS11425	COG2130	NADP-dependent
KRH_RS11430	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KRH_RS11435	COG2202	Pas domain
KRH_RS11435	COG2205	protein histidine kinase activity
KRH_RS11455	COG1388	LysM domain
KRH_RS11465	COG1715	Restriction endonuclease
KRH_RS11475	COG2814	Major facilitator Superfamily
KRH_RS11500	COG0596	Alpha beta hydrolase
KRH_RS11505	COG0514	ATP-dependent DNA helicase (RecQ)
KRH_RS11520	COG0305	Participates in initiation and elongation during chromosome replication
KRH_RS11530	COG0359	binds to the 23S rRNA
KRH_RS11535	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KRH_RS11545	COG0360	Binds together with S18 to 16S ribosomal RNA
KRH_RS11565	COG0617	tRNA 3'-terminal CCA addition
KRH_RS11585	COG0492	ferredoxin-NADP+ reductase activity
KRH_RS11590	COG3118	belongs to the thioredoxin family
KRH_RS11605	COG1192	Involved in chromosome partitioning
KRH_RS11610	COG0357	Ribosomal RNA small subunit methyltransferase G
KRH_RS11620	COG0706	membrane insertase activity
KRH_RS11625	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KRH_RS11630	COG0594	ribonuclease P activity
KRH_RS11635	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KRH_RS11655	COG3226	Transcriptional regulator
KRH_RS11670	COG0477	Major facilitator Superfamily
KRH_RS11675	COG0640	Transcriptional regulator
KRH_RS11760	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KRH_RS11760	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KRH_RS11775	COG0515	serine threonine protein kinase
KRH_RS11815	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
KRH_RS11815	COG2066	Belongs to the glutaminase family
KRH_RS11920	COG2314	TM2 domain