locus-tag	class	description
sake_RS00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
sake_RS00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
sake_RS00015	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
sake_RS00020	ENOG4105K7N	UPF0232 protein
sake_RS00025	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
sake_RS00035	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
sake_RS00040	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
sake_RS00060	ENOG4105DJ2	Major Facilitator Superfamily
sake_RS00095	ENOG4107ZXI	Rhomboid family
sake_RS00115	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
sake_RS00130	ENOG4108Z0Z	intracellular protease Pfpi family
sake_RS00135	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
sake_RS00155	ENOG4105WH1	Two component transcriptional regulator luxr family
sake_RS00160	ENOG4105BZU	Histidine kinase
sake_RS00190	ENOG4105F27	Major Facilitator
sake_RS00205	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
sake_RS00210	ENOG4105CXK	mandelate racemase muconate lactonizing
sake_RS00215	ENOG4105C26	Dehydrogenase
sake_RS00220	ENOG41079KZ	Major Facilitator Superfamily
sake_RS00225	ENOG4105VG5	Membrane
sake_RS00270	ENOG4105CSH	Transporter
sake_RS00275	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
sake_RS00285	ENOG4105C7F	AcnD-accessory protein PrpF
sake_RS00295	ENOG4105CUB	amino acid
sake_RS00340	ENOG4107RNA	Nickel ABC transporter, periplasmic nickel-binding protein
sake_RS00350	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
sake_RS00375	ENOG4105CSV	Glutaminase
sake_RS00420	ENOG4105C57	major facilitator superfamily
sake_RS00440	ENOG4105DRR	Transcriptional regulator, GntR family
sake_RS00445	ENOG4105CFC	Transporter
sake_RS00460	ENOG410635A	Membrane
sake_RS00475	ENOG4108M1A	Chitin-binding protein
sake_RS00480	ENOG4105DRR	Transcriptional regulator, GntR family
sake_RS00485	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
sake_RS00495	ENOG4105CID	antiterminator
sake_RS00510	ENOG4105CZE	histidine utilization repressor
sake_RS00515	ENOG4105CGP	Urocanate hydratase
sake_RS00520	ENOG4105CI2	imidazolone-5-propionate hydrolase
sake_RS00525	ENOG41088SP	formiminoglutamate hydrolase
sake_RS00530	ENOG4105C84	Histidine ammonia-lyase
sake_RS00545	ENOG4105EMN	RNA polymerase sigma factor
sake_RS00550	ENOG4105VBF	alkaline shock protein
sake_RS00590	ENOG4105BZU	Histidine kinase
sake_RS00595	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
sake_RS00605	ENOG41062JF	Transcriptional regulator
sake_RS00620	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
sake_RS00630	ENOG4105CXD	Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity)
sake_RS00655	ENOG4105XBB	septation inhibitor protein
sake_RS00660	ENOG4108U4N	(sortase) family
sake_RS00680	ENOG4107TPY	serine threonine protein kinase
sake_RS00685	ENOG4105CJN	penicillin-binding protein
sake_RS00700	ENOG4105HZM	Fha domain containing protein
sake_RS00720	ENOG4105C7K	acetolactate synthase
sake_RS00725	ENOG4105C94	Transporter
sake_RS00735	ENOG4108KZ5	Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity)
sake_RS00755	ENOG4105VEQ	Cold shock protein
sake_RS00760	ENOG4105EMU	Dehydrogenase
sake_RS00805	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
sake_RS00810	ENOG4108IJ1	Dehydrogenase
sake_RS00830	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
sake_RS00850	ENOG410650H	(LipO)protein
sake_RS00855	ENOG4105DBE	peroxidase
sake_RS00890	ENOG4105C57	major facilitator superfamily
sake_RS00905	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
sake_RS00910	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
sake_RS00920	ENOG4107QKC	Oxidoreductase alpha (molybdopterin) subunit
sake_RS00930	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
sake_RS00935	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
sake_RS00940	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
sake_RS00955	ENOG4105C85	amino acid
sake_RS00975	ENOG4105VPX	protein, conserved in bacteria
sake_RS01020	ENOG4107RSM	transcriptional regulator
sake_RS01035	ENOG4105DIA	mandelate racemase muconate lactonizing
sake_RS01040	ENOG4105EQX	glucarate dehydratase
sake_RS01055	ENOG4107RSM	transcriptional regulator
sake_RS01060	ENOG4105C6Z	Gluconate
sake_RS01065	ENOG4105EQX	glucarate dehydratase
sake_RS01085	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
sake_RS01095	ENOG4105F99	Hydroxymethylglutaryl-CoA synthase
sake_RS01110	ENOG4106YKD	Cytochrome p-450
sake_RS01125	ENOG4105CG3	alpha amylase, catalytic region
sake_RS01140	ENOG4108IJG	ABC transporter substrate-binding protein
sake_RS01155	ENOG4108J4B	Beta-lactamase
sake_RS01170	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
sake_RS01195	ENOG4105C6K	Malic enzyme
sake_RS01235	ENOG4108KC1	acyl-Coa dehydrogenase
sake_RS01260	ENOG4105E2Q	3-(3-hydroxy-phenyl)propionate hydroxylase
sake_RS01270	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
sake_RS01295	ENOG4105K5B	UPF0225 protein
sake_RS01300	ENOG4105C7N	Xanthine uracil vitamin C permease
sake_RS01305	ENOG4105CPC	Aldo Keto reductase
sake_RS01315	ENOG4105CHR	reductase
sake_RS01320	ENOG4107QP6	Xylose isomerase domain protein TIM barrel
sake_RS01325	ENOG4105D7K	pfkb domain protein
sake_RS01335	ENOG4108HRG	Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity)
sake_RS01340	ENOG4105C26	Dehydrogenase
sake_RS01345	ENOG4105CJK	Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity)
sake_RS01350	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
sake_RS01355	ENOG4105F0H	myo-inositol catabolism protein
sake_RS01360	ENOG4107QNK	)-transporter
sake_RS01365	ENOG4105DQ4	alcohol dehydrogenase
sake_RS01370	ENOG4105C2C	drug resistance transporter, Bcr CflA
sake_RS01375	ENOG4105DUM	transcriptional regulator, lysR family
sake_RS01380	ENOG4105ENR	peptidase, M24
sake_RS01385	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
sake_RS01395	ENOG4105CSH	Transporter
sake_RS01400	ENOG4105CHR	reductase
sake_RS01415	ENOG4105DCF	alanine dehydrogenase
sake_RS01420	ENOG4105DWD	nucleoside recognition domain protein
sake_RS01425	ENOG4108YYH	Nadph-dependent fmn reductase
sake_RS01450	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
sake_RS01460	ENOG4105CV8	reductase
sake_RS01475	ENOG4105CPK	Glycosyl transferase (Group 1
sake_RS01485	ENOG4108UXE	Protein tyrosine phosphatase
sake_RS01520	ENOG4105ETE	Transcriptional regulator (LacI family
sake_RS01530	ENOG4108HRG	Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity)
sake_RS01535	ENOG4105CNV	Aldolase
sake_RS01545	ENOG4105CK5	oxidoreductase
sake_RS01550	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
sake_RS01575	ENOG4105DH8	myo-inositol catabolism
sake_RS01585	ENOG4107QNK	)-transporter
sake_RS01605	ENOG4105C5A	transporter
sake_RS01610	ENOG4108JIK	carboxylase
sake_RS01615	ENOG4107R7A	Allophanate hydrolase subunit 2
sake_RS01625	ENOG4107FCW	Abortive infection protein
sake_RS01630	ENOG4105DFM	M18 family aminopeptidase
sake_RS01640	ENOG4105D7K	pfkb domain protein
sake_RS01650	ENOG4108K4B	hydrolase
sake_RS01655	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
sake_RS01660	ENOG4105CPC	Aldo Keto reductase
sake_RS01665	ENOG4105C2W	permease
sake_RS01675	ENOG4105F27	Major Facilitator
sake_RS01680	ENOG4105DUX	Transporter
sake_RS01685	ENOG4105CB5	ATP-dependent DNA helicase recG
sake_RS01695	ENOG41088SP	formiminoglutamate hydrolase
sake_RS01715	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
sake_RS01725	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
sake_RS01730	ENOG4108KP7	hydrolase
sake_RS01760	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
sake_RS01765	ENOG4105EFS	Binding-protein-dependent transport systems, inner membrane component
sake_RS01775	ENOG4105D7T	ABC transporter
sake_RS01780	ENOG4105CHU	acetyl-coa acetyltransferase
sake_RS01785	ENOG4105E39	Enoyl-CoA hydratase
sake_RS01790	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
sake_RS01795	ENOG4105KA0	thioesterase Superfamily protein
sake_RS01800	ENOG4105DXM	phenylacetic acid degradation protein
sake_RS01810	ENOG4105C54	Major Facilitator superfamily
sake_RS01820	ENOG4105ETE	Transcriptional regulator (LacI family
sake_RS01830	ENOG4107QNK	)-transporter
sake_RS01850	ENOG4105CRS	phenylacetate-CoA oxygenase PaaG subunit
sake_RS01855	ENOG4105N76	Phenylacetate-CoA oxygenase, subunit
sake_RS01860	ENOG4105D9S	phenylacetate-CoA oxygenase PaaI subunit
sake_RS01865	ENOG4108ZA2	phenylacetate-CoA oxygenase PaaJ subunit
sake_RS01870	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
sake_RS01875	ENOG41060WC	Enoyl-CoA hydratase
sake_RS01890	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
sake_RS01910	ENOG4105DWF	phosphomethylpyrimidine kinase
sake_RS01920	ENOG4105C5X	domain protein
sake_RS01925	ENOG4105C85	amino acid
sake_RS01955	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
sake_RS01960	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
sake_RS01975	ENOG4105ETS	cytosine purines uracil thiamine allantoin
sake_RS01985	ENOG4107EJG	GntR family transcriptional regulator
sake_RS02000	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
sake_RS02005	ENOG4105C26	Dehydrogenase
sake_RS02015	ENOG4108M8W	Monooxygenase
sake_RS02020	ENOG4105BZP	glycoside hydrolase 15-related
sake_RS02025	ENOG4105CPQ	Dehydrogenase
sake_RS02055	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
sake_RS02085	ENOG41079KZ	Major Facilitator Superfamily
sake_RS02100	ENOG4105D7A	ATP-binding protein
sake_RS02105	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
sake_RS02110	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
sake_RS02115	ENOG4105CEY	Amp-dependent synthetase and ligase
sake_RS02120	ENOG4108TGP	Thioesterase superfamily protein
sake_RS02125	ENOG4107YVI	ribose 5-phosphate isomerase
sake_RS02135	ENOG4105CGD	Nad-dependent epimerase dehydratase
sake_RS02150	ENOG4105EWK	phytoene
sake_RS02155	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
sake_RS02165	ENOG4105E98	transcriptional regulator DeoR family
sake_RS02200	ENOG4105EAH	synthase
sake_RS02210	ENOG4105DQR	SNARE associated Golgi
sake_RS02215	ENOG4105C9U	ATP-dependent DNA helicase RecQ
sake_RS02220	ENOG4105CQ7	ATP-dependent helicase
sake_RS02250	ENOG4105DIK	(ABC) transporter
sake_RS02255	ENOG4105CC5	ABC transporter
sake_RS02280	ENOG4108Z6B	deaminase
sake_RS02285	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
sake_RS02290	ENOG4107NHD	transcriptional regulator
sake_RS02305	ENOG4105KPY	Small multidrug resistance protein
sake_RS02330	ENOG4105K6V	RNA polymerase
sake_RS02345	ENOG4108HHA	Transketolase
sake_RS02350	ENOG4105BZ9	Cytochrome C oxidase, subunit I
sake_RS02355	ENOG4105KT7	mgtC SapB transporter
sake_RS02360	ENOG4105CH6	catalase
sake_RS02385	ENOG4107QNK	)-transporter
sake_RS02390	ENOG4105ETE	Transcriptional regulator (LacI family
sake_RS02405	ENOG4105CAC	Catalyzes the conversion of L-arabinose to L-ribulose (By similarity)
sake_RS02430	ENOG4105D22	carbon starvation protein
sake_RS02440	ENOG4105CDA	abc transporter atp-binding protein
sake_RS02445	ENOG4105DRP	amino acid AbC transporter
sake_RS02450	ENOG4105EAB	amino acid AbC transporter
sake_RS02455	ENOG4105C28	cystathionine
sake_RS02465	ENOG4105K56	Transcriptional regulator
sake_RS02475	ENOG4105WH1	Two component transcriptional regulator luxr family
sake_RS02480	ENOG4108ZGX	Histidine kinase
sake_RS02495	ENOG4105CI0	Citrate lyase
sake_RS02510	ENOG4108375	Acylphosphatase (EC 3.6.1.7)
sake_RS02515	ENOG4105PGM	cation diffusion facilitator family transporter
sake_RS02530	ENOG4107QTF	adenylosuccinate lyase
sake_RS02545	ENOG4105CIH	Imidazole acetol-phosphate transaminase
sake_RS02555	ENOG4105CPP	Dehydrogenase, E1 component
sake_RS02560	ENOG4107RN0	branched-chain alpha-keto acid dehydrogenase subunit E2
sake_RS02570	ENOG4108UW5	maltose o-acetyltransferase
sake_RS02580	ENOG4105CEY	Amp-dependent synthetase and ligase
sake_RS02585	ENOG4108UMI	ABC transporter, permease
sake_RS02590	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
sake_RS02595	ENOG4105D01	(LipO)protein
sake_RS02600	ENOG4105IE8	Alpha-ketoglutarate permease
sake_RS02610	ENOG4105CPQ	Dehydrogenase
sake_RS02615	ENOG4105CMT	Dihydroxyacetone kinase
sake_RS02620	ENOG4105DEI	Mannitol dehydrogenase
sake_RS02630	ENOG4108R85	Short chain dehydrogenase
sake_RS02635	ENOG4105CMG	Carbohydrate kinase
sake_RS02645	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
sake_RS02655	ENOG4105DQ5	transport system permease protein
sake_RS02660	ENOG4105TVJ	transport system, permease
sake_RS02665	ENOG4105E0A	ABC, transporter
sake_RS02680	ENOG4105KDC	50s ribosomal protein l28
sake_RS02685	ENOG4105W0E	50S ribosomal protein L33
sake_RS02690	ENOG41080FR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
sake_RS02695	ENOG4108426	dNA-binding protein
sake_RS02710	ENOG41080T7	secreted protein
sake_RS02720	ENOG4105E4J	Cytochrome c oxidase caa3-type, assembly factor ctag-related protein
sake_RS02740	ENOG4108MIC	Mg-protoporphyrin IX methyl transferase
sake_RS02750	ENOG4105DHP	deoxycytidine triphosphate deaminase
sake_RS02770	ENOG4105D65	subunit l
sake_RS02775	ENOG4105MKQ	Monovalent cation H antiporter subunit C
sake_RS02780	ENOG4108JPZ	Monovalent cation H antiporter subunit D
sake_RS02790	ENOG41080TA	Multiple resistance and ph regulation protein f
sake_RS02795	ENOG4105KJM	monovalent cation h antiporter subunit g
sake_RS02805	ENOG4105NSK	ABC superfamily ATP binding cassette transporter membrane protein
sake_RS02810	ENOG4108JJB	ABC transporter
sake_RS02820	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
sake_RS02825	ENOG4107R34	abc transporter permease protein
sake_RS02830	ENOG4107SCA	Formamidase (EC 3.5.1.49)
sake_RS02845	ENOG4105C2C	drug resistance transporter, Bcr CflA
sake_RS02855	ENOG4105KJF	protein tyrosine phosphatase
sake_RS02870	ENOG4105CFG	Acts as a chaperone (By similarity)
sake_RS02875	ENOG4108093	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
sake_RS02880	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
sake_RS02885	ENOG4105KNI	merR family transcriptional Regulator
sake_RS02890	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
sake_RS02895	ENOG4105BZG	amino acid carrier protein
sake_RS02905	ENOG4107UB3	HAD-superfamily hydrolase subfamily IA variant 3
sake_RS02915	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
sake_RS02925	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
sake_RS02935	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
sake_RS02970	ENOG4105EUS	Binding-protein-dependent transport systems, inner membrane component
sake_RS02985	ENOG4105D4R	Catalyzes the desulfonation of aliphatic sulfonates (By similarity)
sake_RS02990	ENOG4105C12	Phosphoribosylglycinamide synthetase
sake_RS02995	ENOG4105C8V	SAICAR synthetase
sake_RS03000	ENOG41073TP	transcriptional regulator
sake_RS03005	ENOG4105DAA	L-lactate
sake_RS03015	ENOG4107QR9	Iron-sulfur cluster binding protein
sake_RS03020	ENOG41080R8	Conserved Protein
sake_RS03055	ENOG4105DQ4	alcohol dehydrogenase
sake_RS03075	ENOG4105BZ1	(ABC) transporter
sake_RS03080	ENOG4105BZ1	(ABC) transporter
sake_RS03085	ENOG4107RGJ	metallophosphoesterase
sake_RS03090	ENOG4105BZ4	penicillin-binding protein
sake_RS03100	ENOG4105KME	endoribonuclease L-psp
sake_RS03120	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
sake_RS03125	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
sake_RS03185	ENOG4108I5C	dEAD DEAH box helicase
sake_RS03195	ENOG4105C72	UPF0176 protein
sake_RS03200	ENOG4105CHF	Glutathione S-transferase
sake_RS03205	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
sake_RS03210	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
sake_RS03215	ENOG4107R33	ppx gppa phosphatase
sake_RS03220	ENOG4105EY0	Xylose isomerase domain protein TIM barrel
sake_RS03225	ENOG4105II7	pyrroline-5-carboxylate reductase
sake_RS03240	ENOG4105DGU	Histone deacetylase
sake_RS03245	ENOG41082BM	Transcriptional regulator, arsr family
sake_RS03265	ENOG4108RH7	phosphoglycerate mutase
sake_RS03275	ENOG4107QIV	Cytochrome c biogenesis protein
sake_RS03285	ENOG4105CRE	cytochrome C
sake_RS03300	ENOG4105C5Q	Transcriptional regulator
sake_RS03305	ENOG4105DJ2	Major Facilitator Superfamily
sake_RS03320	ENOG4107SIQ	Naphthoate synthase
sake_RS03325	ENOG4105CK7	Sodium proline symporter
sake_RS03335	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
sake_RS03350	ENOG4107TCW	O-succinylbenzoate synthase
sake_RS03360	ENOG4105C6T	cysteine synthase
sake_RS03385	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
sake_RS03390	ENOG4105EHG	Permease protein
sake_RS03395	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
sake_RS03400	ENOG4105EYF	MMPL domain protein
sake_RS03405	ENOG4105MKU	Transcriptional regulator
sake_RS03410	ENOG4105EYF	MMPL domain protein
sake_RS03420	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
sake_RS03460	ENOG4107SET	aldo keto reductase
sake_RS03470	ENOG4107QNK	)-transporter
sake_RS03515	ENOG4105CH6	catalase
sake_RS03525	ENOG4105D0M	Protease HtpX homolog
sake_RS03530	ENOG4108VPT	UPF0234 protein
sake_RS03545	ENOG41080RH	Thioredoxin
sake_RS03575	ENOG410900P	UPF0336 protein
sake_RS03585	ENOG4106UW1	Major Facilitator superfamily
sake_RS03590	ENOG4107R4N	Cell wall formation (By similarity)
sake_RS03605	ENOG4107QJH	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
sake_RS03615	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
sake_RS03625	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
sake_RS03630	ENOG4107NHD	transcriptional regulator
sake_RS03640	ENOG4108X6U	May play a role in the intracellular transport of hydrophobic ligands
sake_RS03650	ENOG4105CTQ	phosphohexokinase
sake_RS03670	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
sake_RS03675	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
sake_RS03680	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
sake_RS03685	ENOG4108IJ9	(ABC) transporter
sake_RS03690	ENOG4108VZM	50s ribosomal protein L10
sake_RS03695	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
sake_RS03700	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
sake_RS03735	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
sake_RS03740	ENOG4105EPU	Molybdenum cofactor synthesis domain protein
sake_RS03750	ENOG41079KZ	Major Facilitator Superfamily
sake_RS03755	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
sake_RS03760	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
sake_RS03770	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
sake_RS03775	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
sake_RS03790	ENOG4107RAW	3-carboxy-cis-cis-muconate cycloisomerase
sake_RS03795	ENOG4108UWZ	4-Carboxymuconolactone decarboxylase
sake_RS03800	ENOG4105CHU	acetyl-coa acetyltransferase
sake_RS03810	ENOG4107QNJ	CoA-transferase subunit B
sake_RS03815	ENOG4107HP6	Transcriptional regulator
sake_RS03820	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
sake_RS03825	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
sake_RS03830	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
sake_RS03835	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
sake_RS03850	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
sake_RS03855	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
sake_RS03860	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
sake_RS03865	ENOG4105KZR	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
sake_RS03870	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
sake_RS03875	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
sake_RS03880	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
sake_RS03885	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
sake_RS03890	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
sake_RS03895	ENOG41082SA	50s ribosomal protein l29
sake_RS03900	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
sake_RS03905	ENOG4105E93	esterase
sake_RS03915	ENOG4105DQ5	transport system permease protein
sake_RS03920	ENOG4105TVJ	transport system, permease
sake_RS03925	ENOG4105E0A	ABC, transporter
sake_RS03930	ENOG4105PEC	Iron-enterobactin transporter periplasmic binding protein
sake_RS03935	ENOG4105CEY	Amp-dependent synthetase and ligase
sake_RS03940	ENOG4105CEY	Amp-dependent synthetase and ligase
sake_RS03965	ENOG4105DQ5	transport system permease protein
sake_RS03970	ENOG4105TVJ	transport system, permease
sake_RS03975	ENOG4105E0A	ABC, transporter
sake_RS03985	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
sake_RS03990	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
sake_RS03995	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
sake_RS04000	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
sake_RS04005	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
sake_RS04010	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
sake_RS04015	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
sake_RS04020	ENOG410849U	50S ribosomal protein L30
sake_RS04025	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
sake_RS04030	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
sake_RS04035	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
sake_RS04045	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
sake_RS04050	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
sake_RS04055	ENOG41067V7	50S ribosomal protein L36
sake_RS04060	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
sake_RS04065	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
sake_RS04070	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
sake_RS04075	ENOG4108ZT0	50S ribosomal protein l17
sake_RS04085	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
sake_RS04090	ENOG4108UJD	30S ribosomal protein S9
sake_RS04095	ENOG4105CSR	polyphosphate kinase 2
sake_RS04100	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
sake_RS04105	ENOG41080FJ	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
sake_RS04110	ENOG4105CS9	pantothenic acid kinase
sake_RS04115	ENOG4105CTS	PTS system mannitol-specific
sake_RS04120	ENOG4107SQ3	mannitol-1-phosphate 5-dehydrogenase
sake_RS04140	ENOG4105D3Q	Sugar transferase
sake_RS04150	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
sake_RS04155	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
sake_RS04160	ENOG4108097	ATP-binding protein
sake_RS04170	ENOG4108Z7F	N-acetyltransferase
sake_RS04175	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
sake_RS04180	ENOG4106KXD	ATP-dependent carboxylate-amine ligase (By similarity)
sake_RS04190	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
sake_RS04195	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
sake_RS04200	ENOG4105EXC	Acyl-transferase
sake_RS04205	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
sake_RS04210	ENOG4107QVP	Dehydrogenase
sake_RS04225	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
sake_RS04245	ENOG41080UU	5-formyltetrahydrofolate cyclo-ligase
sake_RS04250	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
sake_RS04280	ENOG4105D8X	mechanosensitive ion channel
sake_RS04285	ENOG4108RJ7	Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP) (By similarity)
sake_RS04305	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
sake_RS04315	ENOG4105CGY	Dna recombination protein
sake_RS04345	ENOG4105C3G	gtp-binding protein
sake_RS04355	ENOG4108JGH	Tetr family transcriptional regulator
sake_RS04410	ENOG4105CHR	reductase
sake_RS04415	ENOG4108VCA	G U mismatch-specific DNA glycosylase
sake_RS04430	ENOG4105DFH	Transport of potassium into the cell (By similarity)
sake_RS04465	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
sake_RS04470	ENOG4108IQI	permease
sake_RS04475	ENOG4107QNK	)-transporter
sake_RS04480	ENOG4107KM7	Heat induced stress protein YflT
sake_RS04485	ENOG4105E9K	Isocitrate dehydrogenase
sake_RS04495	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
sake_RS04505	ENOG4107QP8	phosphohexose isomerase
sake_RS04515	ENOG4108J59	Extracellular solute-binding protein, family 5
sake_RS04520	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
sake_RS04525	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
sake_RS04530	ENOG4108JQ6	ABC transporter
sake_RS04535	ENOG4105CI3	gtp-binding protein typa
sake_RS04540	ENOG4108KZ5	Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity)
sake_RS04545	ENOG4108Z4U	Ferredoxin
sake_RS04560	ENOG4105CMR	udp-glucose 4-epimerase
sake_RS04565	ENOG4105EJ3	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity)
sake_RS04570	ENOG4107R4C	succinyl-diaminopimelate desuccinylase
sake_RS04605	ENOG4105CJW	magnesium transporter
sake_RS04615	ENOG4107T6F	Xaa-Pro aminopeptidase
sake_RS04625	ENOG4105CEC	DNA methylase N-4 N-6
sake_RS04640	ENOG4108XG4	DNA-binding transcriptional regulator
sake_RS04645	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
sake_RS04650	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
sake_RS04660	ENOG4107JTW	chlorite dismutase
sake_RS04665	ENOG4107QME	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
sake_RS04670	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
sake_RS04680	ENOG4105D52	delta-aminolevulinic acid dehydratase
sake_RS04685	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
sake_RS04700	ENOG4105C4R	Atp-dependent dna helicase
sake_RS04735	ENOG41063PX	domain protein
sake_RS04740	ENOG4105DJZ	UPF0182 protein
sake_RS04755	ENOG41087YS	Phage shock protein A
sake_RS04765	ENOG4105C0H	protease
sake_RS04770	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
sake_RS04780	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
sake_RS04785	ENOG4105EHE	chorismate mutase- prephenate dehydrogenase
sake_RS04795	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
sake_RS04800	ENOG4105BZU	Histidine kinase
sake_RS04805	ENOG4108T3R	lipoprotein lpqB
sake_RS04810	ENOG4107XPQ	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
sake_RS04815	ENOG4108S7Q	sigma 54 modulation protein ribosomal protein S30ea
sake_RS04820	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
sake_RS04845	ENOG4105KRM	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
sake_RS04865	ENOG410602S	Transferase
sake_RS04875	ENOG4105EY8	ABC transporter
sake_RS04885	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
sake_RS04890	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
sake_RS04905	ENOG4107TK4	histidinol-phosphate phosphatase
sake_RS04915	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
sake_RS04925	ENOG4105EMN	RNA polymerase sigma factor
sake_RS04940	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
sake_RS04950	ENOG4105C37	(CBS) domain
sake_RS04955	ENOG4107UAX	integral membrane protein
sake_RS04965	ENOG4105DIK	(ABC) transporter
sake_RS04970	ENOG4105CC5	ABC transporter
sake_RS04990	ENOG4105CQ7	ATP-dependent helicase
sake_RS05005	ENOG4108YZ9	Urea amidohydrolase subunit gamma
sake_RS05010	ENOG4105KI2	Urea amidohydrolase subunit beta
sake_RS05015	ENOG4105CQM	Urea amidohydrolase subunit alpha
sake_RS05020	ENOG41089I8	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity)
sake_RS05025	ENOG4108YH3	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
sake_RS05030	ENOG4107S16	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity)
sake_RS05035	ENOG4105ICD	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
sake_RS05040	ENOG4105D9G	High-affinity
sake_RS05050	ENOG4105C75	arginyL-tRNA synthetase
sake_RS05055	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
sake_RS05060	ENOG4105D6E	homoserine dehydrogenase
sake_RS05065	ENOG4107R5I	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
sake_RS05070	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
sake_RS05080	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
sake_RS05085	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
sake_RS05090	ENOG4107UIY	sua5 ycio yrdc ywlc family protein
sake_RS05100	ENOG4108MKI	Glycosyl transferase, family 2
sake_RS05110	ENOG4105ESV	Glycosyl transferase, family 4
sake_RS05125	ENOG4107UH5	it plays a direct role in the translocation of protons across the membrane (By similarity)
sake_RS05130	ENOG4106DE0	ATP synthase
sake_RS05135	ENOG4107Z0K	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
sake_RS05140	ENOG4108T62	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
sake_RS05145	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
sake_RS05150	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
sake_RS05155	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
sake_RS05160	ENOG410825K	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
sake_RS05165	ENOG4105CYV	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity)
sake_RS05210	ENOG4108RWI	nicotinamidase
sake_RS05220	ENOG4105KEN	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
sake_RS05230	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
sake_RS05240	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
sake_RS05245	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
sake_RS05260	ENOG4107RH8	nuclease SbcCD subunit D
sake_RS05265	ENOG4105EYH	Exonuclease
sake_RS05275	ENOG4105C5X	domain protein
sake_RS05290	ENOG4107U9T	Pfam:Ribonuclease_BN
sake_RS05340	ENOG4108ZP8	Acetolactate synthase small subunit
sake_RS05345	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
sake_RS05370	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
sake_RS05375	ENOG4105CM2	brancheD-chain amino acid aminotransferase
sake_RS05380	ENOG4105ERH	Fumarylacetoacetate hydrolase
sake_RS05385	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
sake_RS05400	ENOG41069M3	Transcriptional regulator
sake_RS05405	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
sake_RS05410	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
sake_RS05415	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
sake_RS05425	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
sake_RS05430	ENOG4105CPF	Cell wall formation (By similarity)
sake_RS05445	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
sake_RS05450	ENOG4105DP4	dak2 domain fusion protein ylov
sake_RS05460	ENOG4106H78	methyltransferase
sake_RS05470	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
sake_RS05480	ENOG41062IY	50S ribosomal protein L32
sake_RS05485	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
sake_RS05490	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
sake_RS05510	ENOG4108Z6Z	Transcriptional regulator
sake_RS05535	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
sake_RS05550	ENOG41082YX	Transcriptional regulator, arsr family
sake_RS05560	ENOG4105H3G	oxidoreductase
sake_RS05570	ENOG4105HS2	Arsenate reductase
sake_RS05580	ENOG4105H3G	oxidoreductase
sake_RS05590	ENOG4105HS2	Arsenate reductase
sake_RS05610	ENOG4105VUN	Transcriptional regulator
sake_RS05650	ENOG4105VPX	protein, conserved in bacteria
sake_RS05660	ENOG41090UD	(LipO)protein
sake_RS05690	ENOG4107R16	Multicopper oxidase
sake_RS05695	ENOG4105C57	major facilitator superfamily
sake_RS05705	ENOG41082SX	arsR family transcriptional regulator
sake_RS05715	ENOG4107VBM	3-beta hydroxysteroid dehydrogenase isomerase
sake_RS05720	ENOG410680H	amp-dependent synthetase and ligase
sake_RS05725	ENOG4105E2T	synthase III
sake_RS05740	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
sake_RS05770	ENOG4105BZU	Histidine kinase
sake_RS05775	ENOG4105WH1	Two component transcriptional regulator luxr family
sake_RS05780	ENOG4105K5M	30s ribosomal protein S16
sake_RS05785	ENOG41084QK	UPF0109 protein
sake_RS05790	ENOG4107XUM	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
sake_RS05795	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
sake_RS05800	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
sake_RS05815	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
sake_RS05820	ENOG41080R2	UPF0102 protein
sake_RS05840	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
sake_RS05855	ENOG41082KT	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
sake_RS05860	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
sake_RS05870	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
sake_RS05885	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
sake_RS05890	ENOG4105D7W	serine acetyltransferase
sake_RS05895	ENOG4105C6T	cysteine synthase
sake_RS05900	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
sake_RS05905	ENOG4105EGD	dinuclear metal center protein, YbgI family
sake_RS05915	ENOG4107XFJ	UPF0246 protein
sake_RS05920	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
sake_RS05935	ENOG4107ZYJ	bioY protein
sake_RS05945	ENOG4105CHU	acetyl-coa acetyltransferase
sake_RS05950	ENOG4108JJB	ABC transporter
sake_RS05965	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
sake_RS05970	ENOG4107JC6	Membrane
sake_RS05990	ENOG4105VHU	single-stranded DNA-binding protein
sake_RS06005	ENOG4105C29	acyl-CoA thioesterase
sake_RS06045	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
sake_RS06050	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
sake_RS06055	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
sake_RS06060	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
sake_RS06070	ENOG4105MC2	DSBA oxidoreductase
sake_RS06080	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
sake_RS06095	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
sake_RS06100	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
sake_RS06115	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
sake_RS06125	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
sake_RS06130	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
sake_RS06145	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
sake_RS06155	ENOG4105C03	ribonuclease
sake_RS06160	ENOG410826X	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
sake_RS06165	ENOG4105K46	50S ribosomal protein l27
sake_RS06170	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
sake_RS06175	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
sake_RS06180	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
sake_RS06190	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
sake_RS06200	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
sake_RS06245	ENOG4105CPC	Aldo Keto reductase
sake_RS06270	ENOG4107RPQ	ABC transporter
sake_RS06290	ENOG4105G3E	Probably involved in ribonucleotide reductase function (By similarity)
sake_RS06295	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
sake_RS06300	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
sake_RS06310	ENOG4105CHH	sulfate transporter
sake_RS06340	ENOG4105CKU	formyltetrahydrofolate synthetase
sake_RS06350	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
sake_RS06355	ENOG4107XGZ	Hydrolase
sake_RS06365	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
sake_RS06370	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
sake_RS06380	ENOG4105CIE	May be required for sporulation (By similarity)
sake_RS06385	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
sake_RS06390	ENOG4105BZA	Phosphoglycerate kinase
sake_RS06395	ENOG4105CP7	Triose-phosphate isomerase
sake_RS06405	ENOG4107XU2	6-phosphogluconolactonase (EC 3.1.1.31)
sake_RS06420	ENOG4107QQX	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
sake_RS06430	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
sake_RS06465	ENOG4105C3K	feS assembly ATPase SufC
sake_RS06470	ENOG4105VG1	fes assembly suf system protein
sake_RS06480	ENOG4105C5H	ABC transporter
sake_RS06500	ENOG4105CHR	reductase
sake_RS06505	ENOG4105CAN	Short-chain dehydrogenase reductase Sdr
sake_RS06510	ENOG4105EAC	phosphoserine phosphatase
sake_RS06515	ENOG4105DKW	ABC transporter
sake_RS06530	ENOG4105NRA	50s ribosomal protein l31 type b
sake_RS06535	ENOG4108KGH	TRANSCRIPTIONal
sake_RS06540	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
sake_RS06565	ENOG4105CHU	acetyl-coa acetyltransferase
sake_RS06570	ENOG4105CHR	reductase
sake_RS06585	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
sake_RS06595	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
sake_RS06600	ENOG4105C8N	cysteinyl-tRNA synthetase
sake_RS06615	ENOG4105DHM	ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity)
sake_RS06620	ENOG4105E5F	proteasome
sake_RS06630	ENOG4105DVV	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity)
sake_RS06635	ENOG41081K0	peptidylprolyl cis-trans isomerase
sake_RS06670	ENOG4105CI2	imidazolone-5-propionate hydrolase
sake_RS06675	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
sake_RS06700	ENOG4108I0Q	anthranilate phosphoribosyltransferase
sake_RS06705	ENOG4105CCU	oxidase (Subunit III)
sake_RS06710	ENOG4107UDY	cytochrome C
sake_RS06715	ENOG4107EUI	c reductase, iron-sulfur
sake_RS06720	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
sake_RS06725	ENOG4108ZRS	Part of cytochrome c oxidase, its function is
sake_RS06730	ENOG4105BZ9	Cytochrome C oxidase, subunit I
sake_RS06735	ENOG4105CV4	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity)
sake_RS06745	ENOG4107S4Y	M20 DapE family protein YgeY
sake_RS06755	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
sake_RS06760	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
sake_RS06765	ENOG4106DBE	Involved in DNA repair and RecF pathway recombination (By similarity)
sake_RS06770	ENOG4107QXN	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
sake_RS06775	ENOG4108KGH	TRANSCRIPTIONal
sake_RS06780	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
sake_RS06790	ENOG4107VNR	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
sake_RS06810	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
sake_RS06815	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
sake_RS06835	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
sake_RS06845	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
sake_RS06865	ENOG4105CR4	methylisocitrate lyase
sake_RS06870	ENOG4105CI2	imidazolone-5-propionate hydrolase
sake_RS06885	ENOG4106NZI	LysR family Transcriptional regulator
sake_RS06890	ENOG4105CNV	Aldolase
sake_RS06910	ENOG4105KQC	Competence protein
sake_RS06915	ENOG4105EPR	degv family
sake_RS06920	ENOG4105C8T	Leucyl-tRNA synthetase
sake_RS06925	ENOG41082A2	Alpha beta hydrolase
sake_RS06940	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
sake_RS06950	ENOG4105MTQ	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
sake_RS06955	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
sake_RS06960	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
sake_RS06965	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
sake_RS06970	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
sake_RS06975	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
sake_RS06985	ENOG4105CD3	dihydroorotase
sake_RS06990	ENOG4105CXT	aspartate transcarbamylase
sake_RS06995	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
sake_RS07000	ENOG410803B	Involved in the transcription termination process (By similarity)
sake_RS07005	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
sake_RS07010	ENOG4105D49	3-dehydroquinate synthase
sake_RS07020	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
sake_RS07025	ENOG4105E2X	shikimate dehydrogenase
sake_RS07040	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
sake_RS07055	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
sake_RS07070	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
sake_RS07080	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
sake_RS07085	ENOG4105CAN	Short-chain dehydrogenase reductase Sdr
sake_RS07090	ENOG4105C1G	acyl-Coa dehydrogenase
sake_RS07095	ENOG4105CEY	Amp-dependent synthetase and ligase
sake_RS07100	ENOG4105C57	major facilitator superfamily
sake_RS07115	ENOG4105E1V	na solute symporter
sake_RS07125	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
sake_RS07195	ENOG4105C54	Major Facilitator superfamily
sake_RS07205	ENOG4105DUM	transcriptional regulator, lysR family
sake_RS07210	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
sake_RS07215	ENOG41081JD	Transcriptional regulator
sake_RS07225	ENOG4107RY6	amino acid
sake_RS07245	ENOG4108JQ1	Dehydrogenase
sake_RS07250	ENOG4105C7K	acetolactate synthase
sake_RS07255	ENOG4105EFZ	amidohydrolase
sake_RS07260	ENOG4105CSH	Transporter
sake_RS07270	ENOG4105C26	Dehydrogenase
sake_RS07275	ENOG4105C1G	acyl-Coa dehydrogenase
sake_RS07280	ENOG4106YT9	Enoyl-CoA hydratase
sake_RS07285	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
sake_RS07290	ENOG4107RSM	transcriptional regulator
sake_RS07295	ENOG4105DAB	fumarate reductase succinate dehydrogenase flavoprotein domain protein
sake_RS07300	ENOG4105CPQ	Dehydrogenase
sake_RS07310	ENOG4107RSM	transcriptional regulator
sake_RS07315	ENOG4105CSH	Transporter
sake_RS07320	ENOG4105DAB	fumarate reductase succinate dehydrogenase flavoprotein domain protein
sake_RS07325	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
sake_RS07345	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
sake_RS07350	ENOG4107RES	phosphoglycerol transferase I
sake_RS07360	ENOG4105CK5	oxidoreductase
sake_RS07365	ENOG4105CT4	transporter
sake_RS07400	ENOG4105C7N	Xanthine uracil vitamin C permease
sake_RS07405	ENOG4107QUY	Guanine deaminase
sake_RS07410	ENOG4105C2W	permease
sake_RS07420	ENOG4105C7W	Xanthine dehydrogenase
sake_RS07450	ENOG4105VT2	5-hydroxyisourate hydrolase
sake_RS07460	ENOG4105C2W	permease
sake_RS07465	ENOG41069M3	Transcriptional regulator
sake_RS07475	ENOG4107R9S	Malate synthase
sake_RS07485	ENOG4105S0E	allantoin catabolism protein
sake_RS07490	ENOG4107TFQ	Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity)
sake_RS07495	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
sake_RS07500	ENOG41060W2	glyoxylate carboligase
sake_RS07505	ENOG4105BZW	Glycerate kinase
sake_RS07545	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
sake_RS07550	ENOG4105C9M	aspartyl-trna synthetase
sake_RS07555	ENOG4105CUT	histidyl-tRNA synthetase
sake_RS07560	ENOG4105C99	atpase involved in dna repair
sake_RS07570	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
sake_RS07580	ENOG4107RSV	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
sake_RS07590	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
sake_RS07595	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
sake_RS07600	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
sake_RS07605	ENOG4105CDY	transcriptional regulatory protein
sake_RS07625	ENOG4108URH	decarboxylase
sake_RS07640	ENOG4107WHG	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
sake_RS07645	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
sake_RS07650	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
sake_RS07660	ENOG4105C22	threonyL-tRNA synthetase
sake_RS07675	ENOG4105EUB	pirin domain protein
sake_RS07685	ENOG4105C0B	DNA polymerase III (alpha subunit)
sake_RS07695	ENOG4105CSH	Transporter
sake_RS07705	ENOG4106NZI	LysR family Transcriptional regulator
sake_RS07720	ENOG4108ZIA	glycerol-3-phosphate responsive antiterminator
sake_RS07725	ENOG4108ITV	Inner membrane protein yqcE
sake_RS07730	ENOG4105CHR	reductase
sake_RS07735	ENOG4107R3A	FAD linked oxidase domain protein
sake_RS07740	ENOG4108CWB	sugar kinase ygcE
sake_RS07745	ENOG4105FDP	GntR family transcriptional regulator
sake_RS07760	ENOG4105CZC	PTS system ascorbate-specific transporter subunit IIC
sake_RS07775	ENOG4105E1V	na solute symporter
sake_RS07810	ENOG4105CEY	Amp-dependent synthetase and ligase
sake_RS07815	ENOG4105C54	Major Facilitator superfamily
sake_RS07825	ENOG4105KVH	Transcriptional regulator
sake_RS07835	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
sake_RS07845	ENOG4105EXW	epimerase dehydratase
sake_RS07850	ENOG4107YCY	Transcriptional regulator
sake_RS07855	ENOG4105C6Z	Gluconate
sake_RS07865	ENOG4105ZXK	Dehydrogenase
sake_RS07870	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
sake_RS07875	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
sake_RS07880	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
sake_RS07895	ENOG4105KA0	thioesterase Superfamily protein
sake_RS07950	ENOG4105CA9	Pyruvate kinase
sake_RS07965	ENOG4105CBC	glutamate synthase
sake_RS07975	ENOG4107TBN	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
sake_RS07980	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
sake_RS07985	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
sake_RS07990	ENOG4105DK0	Indole-3-glycerol phosphate synthase
sake_RS08010	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
sake_RS08020	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
sake_RS08025	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
sake_RS08030	ENOG4105M0N	phosphoribosyl-ATP pyrophosphatase
sake_RS08035	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
sake_RS08040	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
sake_RS08045	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
sake_RS08060	ENOG4105DJV	ribulose-phosphate 3-epimerase
sake_RS08080	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
sake_RS08085	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
sake_RS08125	ENOG4108Z66	YbaK ebsC protein
sake_RS08140	ENOG4105E0X	reductase
sake_RS08150	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
sake_RS08160	ENOG4108UDB	Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity)
sake_RS08165	ENOG4107QM5	aconitate hydratase
sake_RS08170	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
sake_RS08175	ENOG4105C0X	amino acid
sake_RS08180	ENOG4107VEG	TrkA-N domain protein
sake_RS08205	ENOG4107ZFB	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
sake_RS08245	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
sake_RS08265	ENOG4108JJ9	ABC, transporter
sake_RS08270	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
sake_RS08275	ENOG4105C4M	(Ubiquinol oxidase) subunit I
sake_RS08280	ENOG4105D9Z	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
sake_RS08285	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
sake_RS08295	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
sake_RS08310	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
sake_RS08335	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
sake_RS08340	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
sake_RS08355	ENOG4105C5F	glutamine synthetase
sake_RS08365	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
sake_RS08370	ENOG4105C5F	glutamine synthetase
sake_RS08375	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
sake_RS08390	ENOG4105DFK	Polyphosphate glucokinase
sake_RS08395	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
sake_RS08400	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
sake_RS08405	ENOG4105C0B	DNA polymerase III (alpha subunit)
sake_RS08415	ENOG4107ZIW	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
sake_RS08430	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
sake_RS08435	ENOG4105DFA	alanine racemase domain protein
sake_RS08440	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
sake_RS08445	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
sake_RS08450	ENOG4108Z36	domain protein, FtsQ-type
sake_RS08455	ENOG4105DFU	Cell wall formation (By similarity)
sake_RS08460	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
sake_RS08470	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
sake_RS08475	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
sake_RS08485	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
sake_RS08490	ENOG4105CJN	penicillin-binding protein
sake_RS08500	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
sake_RS08505	ENOG4108V6E	Cell division protein mraZ
sake_RS08535	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase
sake_RS08540	ENOG4105E9Q	Acyl-transferase
sake_RS08580	ENOG4108UW8	fha domain-containing protein
sake_RS08585	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
sake_RS08590	ENOG4105C26	Dehydrogenase
sake_RS08600	ENOG4105DKT	Transcriptional regulator
sake_RS08605	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
sake_RS08610	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
sake_RS08615	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
sake_RS08625	ENOG4108R3E	Dna-3-methyladenine glycosylase i
sake_RS08635	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
sake_RS08640	ENOG4105DXB	Major Facilitator superfamily
sake_RS08645	ENOG4108V8F	Transcriptional regulator, MarR family
sake_RS08655	ENOG4105JAB	phenazine biosynthesis protein, phzf family
sake_RS08660	ENOG4105CJH	Alcohol dehydrogenase zinc-binding domain protein
sake_RS08675	ENOG4105C3M	thioredoxin reductase
sake_RS08690	ENOG4105CSH	Transporter
sake_RS08700	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
sake_RS08710	ENOG4105C9U	ATP-dependent DNA helicase RecQ
sake_RS08745	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
sake_RS08750	ENOG4105CAT	Cytidine monophosphate kinase
sake_RS08765	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
sake_RS08770	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
sake_RS08780	ENOG4107QJT	sodium dicarboxylate symporter
sake_RS08785	ENOG4105BZU	Histidine kinase
sake_RS08790	ENOG4108V9W	transcriptional regulatory protein
sake_RS08795	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
sake_RS08810	ENOG4105CR4	methylisocitrate lyase
sake_RS08820	ENOG4105EZR	dyp-type peroxidase family protein
sake_RS08835	ENOG4108YZ4	nudix hydrolase
sake_RS08850	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
sake_RS08865	ENOG4105CDA	abc transporter atp-binding protein
sake_RS08870	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
sake_RS08875	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
sake_RS08880	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
sake_RS08895	ENOG4105DSU	hydrolase
sake_RS08930	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
sake_RS08940	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
sake_RS08945	ENOG4105CH7	arginosuccinase
sake_RS08950	ENOG4105CDH	Citrulline--aspartate ligase
sake_RS08955	ENOG4105JXB	ankyrin repeat-containing protein
sake_RS08960	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
sake_RS08965	ENOG4105DBV	ornithine carbamoyltransferase
sake_RS08970	ENOG4105C8Y	Acetylornithine aminotransferase
sake_RS08975	ENOG4105CAS	nag kinase
sake_RS08980	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
sake_RS08985	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
sake_RS08990	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
sake_RS09000	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
sake_RS09005	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
sake_RS09025	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
sake_RS09030	ENOG41084BS	50S ribosomal protein L35
sake_RS09035	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
sake_RS09050	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
sake_RS09060	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
sake_RS09065	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
sake_RS09070	ENOG4105CIH	Imidazole acetol-phosphate transaminase
sake_RS09080	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
sake_RS09090	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
sake_RS09095	ENOG4107Y49	methyltransferase
sake_RS09100	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
sake_RS09105	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
sake_RS09110	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
sake_RS09120	ENOG4105KC9	Modulates RecA activity (By similarity)
sake_RS09125	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
sake_RS09135	ENOG4105WBV	Transcriptional regulator
sake_RS09140	ENOG4105CEV	competence damage-inducible protein
sake_RS09160	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
sake_RS09170	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
sake_RS09175	ENOG4105EXC	Acyl-transferase
sake_RS09195	ENOG4105CEY	Amp-dependent synthetase and ligase
sake_RS09195	ENOG4105CEY	Amp-dependent synthetase and ligase
sake_RS09205	ENOG4108IQC	2,3-dihydroxybenzoate-AMP ligase
sake_RS09210	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
sake_RS09215	ENOG4105EHG	Permease protein
sake_RS09220	ENOG4107R4I	Periplasmic binding protein
sake_RS09225	ENOG4105BZ1	(ABC) transporter
sake_RS09240	ENOG4105WQI	isochorismatase
sake_RS09245	ENOG4105X17	23-dihydro-2,3-dihydroxybenzoate dehydrogenase
sake_RS09250	ENOG4105E4F	Isochorismate synthase
sake_RS09265	ENOG4105DTQ	mandelate racemase muconate lactonizing
sake_RS09280	ENOG4105C1V	Peptidase, M16
sake_RS09285	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
sake_RS09290	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
sake_RS09295	ENOG4108VX5	3-methyladenine DNA glycosylase
sake_RS09300	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
sake_RS09305	ENOG4107R6G	Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity)
sake_RS09315	ENOG4107QMH	DNA methylase
sake_RS09325	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
sake_RS09330	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
sake_RS09335	ENOG4105CV8	reductase
sake_RS09360	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
sake_RS09365	ENOG4107ZPY	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
sake_RS09370	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
sake_RS09385	ENOG4107Z1I	Required for maturation of 30S ribosomal subunits (By similarity)
sake_RS09400	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
sake_RS09410	ENOG4105DZP	Membrane-associated zinc metalloprotease
sake_RS09415	ENOG4105BZ1	(ABC) transporter
sake_RS09430	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
sake_RS09435	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
sake_RS09440	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
sake_RS09445	ENOG4105CE9	30S ribosomal protein S2
sake_RS09515	ENOG4108FKH	Transglycosylase SLT domain
sake_RS09735	ENOG4107T65	Integrase
sake_RS09745	ENOG4105CG5	Glycosyl transferase (Group 1
sake_RS09765	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
sake_RS09775	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
sake_RS09780	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
sake_RS09795	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
sake_RS09815	ENOG4105DWV	Homoserine O-trans-acetylase
sake_RS09820	ENOG4108IQK	o-acetylhomoserine
sake_RS09825	ENOG4105C85	amino acid
sake_RS09835	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
sake_RS09840	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
sake_RS09845	ENOG41081AP	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
sake_RS09855	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
sake_RS09860	ENOG4108ZF3	Phosphatase
sake_RS09875	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
sake_RS09885	ENOG4105D8K	carboxyl transferase
sake_RS09900	ENOG4108ETY	sodium dicarboxylate symporter
sake_RS09905	ENOG4105C26	Dehydrogenase
sake_RS09910	ENOG4107WR6	Maf-like protein
sake_RS09915	ENOG4108JIK	carboxylase
sake_RS09920	ENOG4105CSH	Transporter
sake_RS09935	ENOG4107QSU	Phosphoglucomutase phosphomannomutase alpha beta alpha domain
sake_RS09940	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
sake_RS09960	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
sake_RS09965	ENOG4108UNV	SUF system FeS assembly protein, NifU family
sake_RS09975	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
sake_RS09980	ENOG4107XT7	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
sake_RS09990	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
sake_RS10035	ENOG4107RJ7	Glycosyl transferase (Group 1
sake_RS10040	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
sake_RS10045	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
sake_RS10055	ENOG4105C5H	ABC transporter
sake_RS10060	ENOG4105CEY	Amp-dependent synthetase and ligase
sake_RS10060	ENOG4105CEY	Amp-dependent synthetase and ligase
sake_RS10085	ENOG4105C54	Major Facilitator superfamily
sake_RS10095	ENOG4105C84	Histidine ammonia-lyase
sake_RS10100	ENOG4105C6Z	Gluconate
sake_RS10110	ENOG4107YCY	Transcriptional regulator
sake_RS10130	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
sake_RS10135	ENOG4105F8V	Hydrolase, tatD family
sake_RS10155	ENOG4107UBC	ErfK ybiS ycfS ynhG family protein
sake_RS10165	ENOG4105K51	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
sake_RS10180	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
sake_RS10190	ENOG4108KGH	TRANSCRIPTIONal
sake_RS10200	ENOG4105BZ1	(ABC) transporter
sake_RS10215	ENOG4108V9Q	carbonic anhydrase
sake_RS10220	ENOG4105C9Q	fumarate hydratase class II
sake_RS10235	ENOG4105C7K	acetolactate synthase
sake_RS10250	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
sake_RS10265	ENOG4105T1M	mycothiol conjugate amidase mca
sake_RS10275	ENOG4107YD5	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
sake_RS10280	ENOG4105C7B	Threonine dehydratase
sake_RS10325	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
sake_RS10330	ENOG4105DXN	mazG family
sake_RS10335	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
sake_RS10360	ENOG4105UIB	(ABC) transporter
sake_RS10365	ENOG4108JQ9	ABC transporter
sake_RS10370	ENOG4105DIH	basic membrane
sake_RS10375	ENOG4107RM1	amidohydrolase
sake_RS10380	ENOG4105E33	succinate dehydrogenase
sake_RS10410	ENOG4105C31	Tryptophanyl-tRNA synthetase
sake_RS10425	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
sake_RS10430	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
sake_RS10440	ENOG4105C09	Bile acid
sake_RS10445	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
sake_RS10450	ENOG4105CXK	mandelate racemase muconate lactonizing
sake_RS10455	ENOG4105CT4	transporter
sake_RS10460	ENOG4105CNT	hydrolase family 2
sake_RS10465	ENOG4105DEI	Mannitol dehydrogenase
sake_RS10470	ENOG4105D2H	Uronic isomerase
sake_RS10475	ENOG4105ETE	Transcriptional regulator (LacI family
sake_RS10500	ENOG4107S5I	aldo keto reductase
sake_RS10515	ENOG4105BZF	Glycosyl transferase (Group 1
sake_RS10530	ENOG4105C0D	helicase
sake_RS10535	ENOG4105C94	Transporter
sake_RS10555	ENOG4105CV8	reductase
sake_RS10565	ENOG4105D94	Major Facilitator Superfamily
sake_RS10575	ENOG4105CNG	UPF0061 protein
sake_RS10585	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
sake_RS10590	ENOG4105CSH	Transporter
sake_RS10640	ENOG4107104	thymidine kinase
sake_RS10645	ENOG4107R5H	iron (metal) dependent repressor, dtxr family
sake_RS10650	ENOG4107R8H	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
sake_RS10655	ENOG4107SFI	Major Facilitator superfamily
sake_RS10665	ENOG4105VEQ	Cold shock protein
sake_RS10675	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
sake_RS10680	ENOG4105BZU	Histidine kinase
sake_RS10690	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
sake_RS10695	ENOG4105E4F	Isochorismate synthase
sake_RS10710	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
sake_RS10725	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
sake_RS10745	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
sake_RS10750	ENOG4105DM4	PTS System
sake_RS10755	ENOG4105DE4	1-phosphofructokinase
sake_RS10760	ENOG4105E98	transcriptional regulator DeoR family
sake_RS10765	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
sake_RS10780	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
sake_RS10795	ENOG4105C1K	alpha-alpha-trehalose-phosphate synthase
sake_RS10815	ENOG4105C2N	RNA methyltransferase TrmH family group 3
sake_RS10820	ENOG4105C8N	cysteinyl-tRNA synthetase
sake_RS10825	ENOG4108VJ1	Transcriptional regulator (CarD family
sake_RS10840	ENOG4105BZU	Histidine kinase
sake_RS10850	ENOG4107RPC	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
sake_RS10865	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
sake_RS10870	ENOG4105C6E	dna polymerase iii
sake_RS10875	ENOG4105CAG	UPF0210 protein
sake_RS10885	ENOG4105DSF	transport protein
sake_RS10890	ENOG4105EIP	mannose-6-phosphate isomerase
sake_RS10895	ENOG4107QKV	phosphomannomutase
sake_RS10900	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
sake_RS10910	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
sake_RS10930	ENOG4108RDT	NADH dehydrogenase NAD(P)H nitroreductase)
sake_RS10940	ENOG4107QRT	dEAD DEAH box helicase
sake_RS10945	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
sake_RS10950	ENOG4105CUB	amino acid
sake_RS10980	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
sake_RS11010	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
sake_RS11025	ENOG4105CAQ	asparagine synthetase
sake_RS11040	ENOG4105CJW	magnesium transporter
sake_RS11065	ENOG4105K56	Transcriptional regulator
sake_RS11070	ENOG4108ZHJ	Organic hydroperoxide resistance protein
sake_RS11130	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
sake_RS11140	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
sake_RS11145	ENOG4107Y5I	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
sake_RS11150	ENOG4105C26	Dehydrogenase
sake_RS11185	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
sake_RS11200	ENOG4107QJG	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
sake_RS11215	ENOG4105E59	Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity)
sake_RS11245	ENOG4105CRK	lysyL-tRNA synthetase
sake_RS11250	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
sake_RS11275	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
sake_RS11285	ENOG4105EEI	dihydropteroate synthase
sake_RS11290	ENOG4105EUJ	GTP cyclohydrolase i
sake_RS11295	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
sake_RS11305	ENOG4107RD1	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
sake_RS11320	ENOG4105F0N	pyrophosphate phospho-hydrolase
sake_RS11330	ENOG4105CUB	amino acid
sake_RS11340	ENOG4108Z86	Glutamine amidotransferase
sake_RS11350	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
sake_RS11355	ENOG4105CH2	amidohydrolase
sake_RS11375	ENOG4105ETS	cytosine purines uracil thiamine allantoin
sake_RS11380	ENOG4107XWI	flavin reductase domain protein, FMN-binding
sake_RS11385	ENOG4105CPN	adenine deaminase
sake_RS11390	ENOG4105C5Y	PTS System
sake_RS11395	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
sake_RS11400	ENOG4106KNT	transcriptional regulator
sake_RS11405	ENOG4105G3E	Probably involved in ribonucleotide reductase function (By similarity)
sake_RS11410	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
sake_RS11415	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
sake_RS11445	ENOG4105CE4	GlcNAc 6-P deacetylase
sake_RS11455	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
sake_RS11460	ENOG4105C9S	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity)
sake_RS11465	ENOG4105DKQ	ROK family
sake_RS11470	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
sake_RS11475	ENOG4108JQ7	(ABC) transporter
sake_RS11490	ENOG4108J59	Extracellular solute-binding protein, family 5
sake_RS11495	ENOG4105CZE	histidine utilization repressor
sake_RS11505	ENOG4107QRS	glycosyltransferase group 2 family protein
sake_RS11510	ENOG4107SI7	Substrate-binding region of abc-type glycine betaine transport system
sake_RS11515	ENOG4105E90	ABC transporter
sake_RS11520	ENOG4108IJ8	ABC transporter
sake_RS11525	ENOG4105E90	ABC transporter
sake_RS11535	ENOG4105K4P	CoA-binding domain protein
sake_RS11545	ENOG4105EQ0	Major Facilitator superfamily
sake_RS11585	ENOG4105C01	Dihydroxy-acid dehydratase
sake_RS11590	ENOG4105BZ1	(ABC) transporter
sake_RS11620	ENOG4105CI1	PTS System
sake_RS11630	ENOG4105CHU	acetyl-coa acetyltransferase
sake_RS11635	ENOG4105D7N	magnesium and cobalt transport protein CorA
sake_RS11640	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
sake_RS11650	ENOG4105DCF	alanine dehydrogenase
sake_RS11680	ENOG41065E1	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
sake_RS11690	ENOG4105CBC	glutamate synthase
sake_RS11695	ENOG4105C1G	acyl-Coa dehydrogenase
sake_RS11700	ENOG4105CEY	Amp-dependent synthetase and ligase
sake_RS11705	ENOG4105F2C	Acetyl-CoA acetyltransferase
sake_RS11715	ENOG4105C1G	acyl-Coa dehydrogenase
sake_RS11720	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
sake_RS11745	ENOG4105E39	Enoyl-CoA hydratase
sake_RS11755	ENOG4105E39	Enoyl-CoA hydratase
sake_RS11760	ENOG4105C26	Dehydrogenase
sake_RS11765	ENOG4105I7Z	Short-chain dehydrogenase reductase Sdr
sake_RS11780	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
sake_RS11805	ENOG4108R6G	acetyltransferase
sake_RS11810	ENOG4105D9U	N-acetyltransferase
sake_RS11830	ENOG4105KNA	-acetyltransferase
sake_RS11835	ENOG4105CSH	Transporter
sake_RS11850	ENOG4105KME	endoribonuclease L-psp
sake_RS11855	ENOG4105H3G	oxidoreductase
sake_RS11860	ENOG4108KB2	LysR family Transcriptional regulator
sake_RS11890	ENOG4105C9K	Endothelin-converting enzyme 1
sake_RS11900	ENOG4105E7W	lamb ycsf family protein
sake_RS11905	ENOG4108VJY	integral membrane protein
sake_RS11930	ENOG4105C26	Dehydrogenase
sake_RS11945	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
sake_RS11960	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
sake_RS11970	ENOG4108JCI	Transcriptional regulator
sake_RS11980	ENOG4105C7K	acetolactate synthase
sake_RS11995	ENOG41083TI	Protein CrcB homolog
sake_RS12000	ENOG4107JBM	CrcB-like protein
sake_RS12010	ENOG4105E5M	Multidrug resistance protein D
sake_RS12015	ENOG4105C5I	Dehydrogenase
sake_RS12035	ENOG4105CHR	reductase
sake_RS12045	ENOG4105C26	Dehydrogenase
sake_RS12055	ENOG4105CPQ	Dehydrogenase
sake_RS12090	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
sake_RS12125	ENOG4107YCY	Transcriptional regulator
sake_RS12130	ENOG4105D4T	Citrate transporter
sake_RS12140	ENOG4105DWF	phosphomethylpyrimidine kinase
sake_RS12145	ENOG4105DWF	phosphomethylpyrimidine kinase
sake_RS12150	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
sake_RS12160	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
sake_RS12165	ENOG4105DUM	transcriptional regulator, lysR family
sake_RS12180	ENOG4105E90	ABC transporter
sake_RS12185	ENOG4105E90	ABC transporter
sake_RS12190	ENOG4108IJ8	ABC transporter
sake_RS12195	ENOG4105FDP	GntR family transcriptional regulator
sake_RS12205	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
sake_RS12215	ENOG4105CRK	lysyL-tRNA synthetase
sake_RS12255	ENOG4105C6Z	Gluconate
sake_RS12265	ENOG4107YB1	Trehalose corynomycolyl transferase
sake_RS12280	ENOG4105C85	amino acid
sake_RS12285	ENOG4108JPW	Aminotransferase
sake_RS12325	ENOG4105DWY	Agmatine deiminase
sake_RS12335	ENOG4105KF3	Short-chain dehydrogenase reductase Sdr
sake_RS12345	ENOG4105C1G	acyl-Coa dehydrogenase
sake_RS12360	ENOG4105CSH	Transporter
sake_RS12415	ENOG4105W1Y	Transcriptional regulator
sake_RS12425	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
sake_RS12445	ENOG4105C26	Dehydrogenase
sake_RS12450	ENOG4108WYP	Transcriptional regulator
sake_RS12455	ENOG4105JSC	dimethylmenaquinone methyltransferase
sake_RS12460	ENOG4105CSH	Transporter
sake_RS12465	ENOG4105CUB	amino acid
sake_RS12475	ENOG4107XM9	(LipO)protein
sake_RS12490	ENOG41069M3	Transcriptional regulator
sake_RS12495	ENOG4105QPS	Monooxygenase
sake_RS12500	ENOG4105CH2	amidohydrolase
sake_RS12510	ENOG4105C26	Dehydrogenase
sake_RS12520	ENOG4105CQB	FAD linked oxidase domain protein
sake_RS12525	ENOG4105C7I	Dehydrogenase
sake_RS12530	ENOG4105VG5	Membrane
sake_RS12535	ENOG4105JP4	Inner membrane protein yidG
sake_RS12540	ENOG4105C7I	Dehydrogenase
sake_RS12565	ENOG4105CKK	Glycosyl transferase, family 2
sake_RS12600	ENOG4105DEN	Luciferase family
sake_RS12605	ENOG4105C85	amino acid
sake_RS12610	ENOG4105EBR	Carboxylesterase
sake_RS12620	ENOG4105CSH	Transporter
sake_RS12625	ENOG4105HDK	L-asparaginase
sake_RS12635	ENOG4105EN6	Membrane
sake_RS12640	ENOG4106178	UPF0339 protein
sake_RS12645	ENOG4105CSH	Transporter
sake_RS12650	ENOG4107S5I	aldo keto reductase
sake_RS12660	ENOG4105CSH	Transporter
sake_RS12665	ENOG4108IAB	Phoh family
sake_RS12690	ENOG4105CSH	Transporter
sake_RS12695	ENOG4105CE7	Amidase, hydantoinase carbamoylase family
sake_RS12700	ENOG4105CI2	imidazolone-5-propionate hydrolase
sake_RS12710	ENOG4105WH1	Two component transcriptional regulator luxr family
sake_RS12715	ENOG4105BZU	Histidine kinase
sake_RS12735	ENOG4107S9B	Shikimate dehydrogenase
sake_RS12755	ENOG4108C33	Resolvase
sake_RS12770	ENOG4105D9U	N-acetyltransferase
sake_RS12780	ENOG4105CSH	Transporter
sake_RS12795	ENOG4105CSH	Transporter
sake_RS12805	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
sake_RS12815	ENOG41080V3	Major Facilitator superfamily
sake_RS12820	ENOG4106XMA	In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity)
sake_RS12825	ENOG4105DY8	decarboxylase
sake_RS12830	ENOG4105F1Y	L-lysine 6-monooxygenase (NADPH)
sake_RS12850	ENOG4105DGI	Alkaline phosphatase
sake_RS12865	ENOG4105CUC	YeeE YedE family protein
sake_RS12870	ENOG4105F27	Major Facilitator
sake_RS12925	ENOG4105CPN	adenine deaminase
sake_RS12930	ENOG4105EMU	Dehydrogenase
sake_RS12945	ENOG4105CSH	Transporter
sake_RS12965	ENOG4105KHM	amidohydrolase 2
sake_RS12980	ENOG4105GAK	amidohydrolase 2
sake_RS12990	ENOG4105D2S	major facilitator superfamily
sake_RS13005	ENOG4105CPC	Aldo Keto reductase
sake_RS13015	ENOG4105CDU	Replicative dna helicase
sake_RS13020	ENOG4105BZW	Glycerate kinase
sake_RS13030	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
sake_RS13035	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
sake_RS13045	ENOG410829C	Binds together with S18 to 16S ribosomal RNA (By similarity)
sake_RS13060	ENOG4105CJ1	ABC, transporter
sake_RS13085	ENOG4105C3M	thioredoxin reductase
sake_RS13090	ENOG4105K63	Thioredoxin
sake_RS13095	ENOG4105FA0	parb-like partition protein
sake_RS13100	ENOG4107QJE	Chromosome Partitioning Protein
sake_RS13105	ENOG4107XUG	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
sake_RS13115	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
sake_RS13120	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
sake_RS13150	ENOG4105CFC	Transporter
sake_RS13180	ENOG4105HS2	Arsenate reductase
sake_RS13190	ENOG4105CT3	Monooxygenase
sake_RS13205	ENOG4108C33	Resolvase
sake_RS13280	ENOG4105D85	methylase