locus-tag	class	description
sake_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
sake_RS00010	COG0592	DNA-directed DNA polymerase activity
sake_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
sake_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
sake_RS00025	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
sake_RS00035	COG0187	DNA topoisomerase II activity
sake_RS00040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
sake_RS00060	COG2807	transmembrane transport
sake_RS00095	COG0705	Rhomboid family
sake_RS00095	COG0457	Tetratricopeptide repeat
sake_RS00100	COG0791	NLP P60 protein
sake_RS00100	COG1388	LysM domain
sake_RS00100	COG3103	Sh3 type 3 domain protein
sake_RS00115	COG1902	pentaerythritol trinitrate reductase activity
sake_RS00130	COG0693	protein deglycase activity
sake_RS00135	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
sake_RS00140	COG0025	NhaP-type Na H and K H
sake_RS00155	COG2197	response regulator
sake_RS00160	COG4585	Histidine kinase
sake_RS00190	COG2814	Major facilitator Superfamily
sake_RS00210	COG4948	Mandelate Racemase Muconate Lactonizing
sake_RS00215	COG1012	belongs to the aldehyde dehydrogenase family
sake_RS00220	COG0477	Major facilitator Superfamily
sake_RS00225	COG2149	membrane
sake_RS00250	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
sake_RS00270	COG0477	Major facilitator Superfamily
sake_RS00275	COG0404	The glycine cleavage system catalyzes the degradation of glycine
sake_RS00275	COG0446	pyridine nucleotide-disulphide oxidoreductase
sake_RS00285	COG2828	Protein conserved in bacteria
sake_RS00295	COG0531	amino acid
sake_RS00340	COG0747	negative chemotaxis
sake_RS00350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
sake_RS00370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
sake_RS00375	COG2066	Belongs to the glutaminase family
sake_RS00420	COG0477	Major facilitator Superfamily
sake_RS00440	COG1802	Transcriptional regulator
sake_RS00445	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
sake_RS00460	COG0730	response to heat
sake_RS00475	COG3397	chitin binding
sake_RS00480	COG1802	Transcriptional regulator
sake_RS00485	COG1404	Belongs to the peptidase S8 family
sake_RS00490	COG1215	transferase activity, transferring glycosyl groups
sake_RS00495	COG3711	transcriptional antiterminator
sake_RS00515	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
sake_RS00520	COG1228	amidohydrolase
sake_RS00525	COG0010	Belongs to the arginase family
sake_RS00530	COG2986	histidine ammonia-lyase
sake_RS00545	COG1595	DNA-templated transcription, initiation
sake_RS00550	COG1302	Protein conserved in bacteria
sake_RS00590	COG2205	protein histidine kinase activity
sake_RS00595	COG0745	RESPONSE REGULATOR receiver
sake_RS00630	COG0583	DNA-binding transcription factor activity
sake_RS00635	COG1053	succinate dehydrogenase
sake_RS00635	COG3976	FMN-binding domain protein
sake_RS00660	COG3764	Sortase (surface protein transpeptidase)
sake_RS00675	COG0515	serine threonine protein kinase
sake_RS00680	COG0515	serine threonine protein kinase
sake_RS00685	COG0768	penicillin binding
sake_RS00700	COG1716	ATPase activity
sake_RS00720	COG0028	Belongs to the TPP enzyme family
sake_RS00725	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
sake_RS00735	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
sake_RS00755	COG1278	Cold shock
sake_RS00760	COG4221	oxidoreductase activity
sake_RS00785	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
sake_RS00805	COG0297	glycogen (starch) synthase activity
sake_RS00810	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
sake_RS00845	COG0672	)-iron permease
sake_RS00850	COG2822	iron ion transport
sake_RS00855	COG2837	iron assimilation
sake_RS00865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
sake_RS00890	COG0477	Major facilitator Superfamily
sake_RS00905	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
sake_RS00905	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
sake_RS00910	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
sake_RS00920	COG0243	molybdopterin cofactor binding
sake_RS00925	COG1063	alcohol dehydrogenase
sake_RS00930	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
sake_RS00935	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
sake_RS00940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
sake_RS00955	COG1113	amino acid transport
sake_RS00975	COG1937	Protein conserved in bacteria
sake_RS00985	COG0488	(ABC) transporter
sake_RS01020	COG0583	DNA-binding transcription factor activity
sake_RS01040	COG4948	Mandelate Racemase Muconate Lactonizing
sake_RS01055	COG0583	DNA-binding transcription factor activity
sake_RS01060	COG2610	gluconate transmembrane transporter activity
sake_RS01065	COG4948	Mandelate Racemase Muconate Lactonizing
sake_RS01085	COG1304	FMN binding
sake_RS01095	COG3425	synthase
sake_RS01110	COG2124	cytochrome p450
sake_RS01125	COG0366	Alpha amylase catalytic
sake_RS01130	COG0395	ABC-type sugar transport system, permease component
sake_RS01140	COG1653	transport
sake_RS01150	COG3842	ATPase activity
sake_RS01155	COG2367	Beta-lactamase
sake_RS01165	COG0477	Major facilitator Superfamily
sake_RS01170	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
sake_RS01180	COG0783	Belongs to the Dps family
sake_RS01195	COG0280	phosphate acetyltransferase
sake_RS01195	COG0857	belongs to the CobB CobQ family
sake_RS01235	COG1960	acyl-CoA dehydrogenase activity
sake_RS01250	COG0179	Fumarylacetoacetate (FAA) hydrolase
sake_RS01260	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
sake_RS01270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
sake_RS01295	COG3012	SEC-C Motif Domain Protein
sake_RS01300	COG2252	PERMEase
sake_RS01305	COG0667	Aldo Keto reductase
sake_RS01320	COG1082	Xylose isomerase domain protein TIM barrel
sake_RS01325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
sake_RS01335	COG3962	Belongs to the TPP enzyme family
sake_RS01345	COG1082	Xylose isomerase domain protein TIM barrel
sake_RS01350	COG0673	inositol 2-dehydrogenase activity
sake_RS01355	COG1082	Xylose isomerase domain protein TIM barrel
sake_RS01360	COG2814	Major facilitator Superfamily
sake_RS01365	COG1064	alcohol dehydrogenase
sake_RS01370	COG2814	Major facilitator Superfamily
sake_RS01375	COG0583	DNA-binding transcription factor activity
sake_RS01380	COG0006	proline dipeptidase activity
sake_RS01385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
sake_RS01390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
sake_RS01395	COG0477	Major facilitator Superfamily
sake_RS01400	COG1028	Short-chain dehydrogenase reductase Sdr
sake_RS01405	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
sake_RS01415	COG0686	Belongs to the AlaDH PNT family
sake_RS01425	COG0431	NADPH-dependent FMN reductase
sake_RS01435	COG0673	inositol 2-dehydrogenase activity
sake_RS01440	COG0673	inositol 2-dehydrogenase activity
sake_RS01450	COG0297	glycogen (starch) synthase activity
sake_RS01460	COG0656	L-ascorbic acid biosynthetic process
sake_RS01475	COG0438	transferase activity, transferring glycosyl groups
sake_RS01485	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
sake_RS01490	COG0489	protein tyrosine kinase activity
sake_RS01490	COG3206	protein involved in exopolysaccharide biosynthesis
sake_RS01520	COG1609	Transcriptional regulator
sake_RS01525	COG1012	belongs to the aldehyde dehydrogenase family
sake_RS01530	COG3962	Belongs to the TPP enzyme family
sake_RS01545	COG0673	inositol 2-dehydrogenase activity
sake_RS01575	COG3718	enzyme involved in inositol metabolism
sake_RS01585	COG2814	Major facilitator Superfamily
sake_RS01605	COG1914	H( )-stimulated, divalent metal cation uptake system
sake_RS01610	COG4770	biotin carboxylase activity
sake_RS01615	COG1984	allophanate hydrolase subunit 2
sake_RS01625	COG1266	CAAX protease self-immunity
sake_RS01630	COG1362	aminopeptidase activity
sake_RS01640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
sake_RS01650	COG0561	phosphatase activity
sake_RS01655	COG0584	glycerophosphoryl diester phosphodiesterase
sake_RS01660	COG0667	Aldo Keto reductase
sake_RS01665	COG2233	PERMEase
sake_RS01675	COG2814	Major facilitator Superfamily
sake_RS01680	COG3104	oligopeptide transport
sake_RS01695	COG0010	Belongs to the arginase family
sake_RS01715	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
sake_RS01725	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
sake_RS01730	COG0561	phosphatase activity
sake_RS01760	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
sake_RS01765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
sake_RS01775	COG1116	anion transmembrane transporter activity
sake_RS01785	COG1024	Enoyl-CoA hydratase
sake_RS01790	COG1250	3-hydroxyacyl-CoA dehydrogenase
sake_RS01795	COG2050	protein possibly involved in aromatic compounds catabolism
sake_RS01800	COG1012	belongs to the aldehyde dehydrogenase family
sake_RS01800	COG2030	dehydratase
sake_RS01810	COG2814	Major facilitator Superfamily
sake_RS01830	COG2814	Major facilitator Superfamily
sake_RS01850	COG3396	Phenylacetate-CoA oxygenase
sake_RS01855	COG3460	Phenylacetate-CoA oxygenase
sake_RS01860	COG3396	Phenylacetate-CoA oxygenase
sake_RS01865	COG2151	metal-sulfur cluster biosynthetic enzyme
sake_RS01870	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
sake_RS01875	COG1024	Enoyl-CoA hydratase
sake_RS01890	COG0477	Major facilitator Superfamily
sake_RS01910	COG0351	phosphomethylpyrimidine kinase
sake_RS01920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
sake_RS01925	COG1113	amino acid transport
sake_RS01955	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
sake_RS01960	COG0047	phosphoribosylformylglycinamidine synthase activity
sake_RS01975	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
sake_RS01985	COG2186	Transcriptional regulator
sake_RS02000	COG0596	Alpha beta hydrolase
sake_RS02005	COG1012	belongs to the aldehyde dehydrogenase family
sake_RS02010	COG1942	4-Oxalocrotonate Tautomerase
sake_RS02015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
sake_RS02020	COG3387	PFAM Glycoside hydrolase 15-related
sake_RS02025	COG1063	alcohol dehydrogenase
sake_RS02055	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
sake_RS02085	COG0477	Major facilitator Superfamily
sake_RS02100	COG0433	COG0433 Predicted ATPase
sake_RS02110	COG1114	Component of the transport system for branched-chain amino acids
sake_RS02115	COG0318	PFAM AMP-dependent synthetase and ligase
sake_RS02120	COG0824	Thioesterase
sake_RS02125	COG0698	ribose 5-phosphate isomerase
sake_RS02135	COG0702	epimerase
sake_RS02150	COG1233	COG1233 Phytoene dehydrogenase and related
sake_RS02155	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
sake_RS02200	COG0142	geranyltranstransferase activity
sake_RS02210	COG0586	Pfam SNARE associated Golgi protein
sake_RS02215	COG0514	ATP-dependent DNA helicase (RecQ)
sake_RS02220	COG1643	Atp-dependent helicase
sake_RS02250	COG1121	(ABC) transporter
sake_RS02255	COG1108	ABC-type Mn2 Zn2 transport systems permease components
sake_RS02280	COG0590	tRNA wobble adenosine to inosine editing
sake_RS02285	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
sake_RS02290	COG0745	RESPONSE REGULATOR receiver
sake_RS02345	COG3959	Transketolase, thiamine diphosphate binding domain
sake_RS02350	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
sake_RS02355	COG1285	pathogenesis
sake_RS02390	COG1609	Transcriptional regulator
sake_RS02405	COG2160	L-arabinose isomerase activity
sake_RS02430	COG1966	Carbon starvation protein
sake_RS02445	COG0765	amino acid transport
sake_RS02450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
sake_RS02455	COG0626	cystathionine gamma-synthase activity
sake_RS02465	COG1846	Transcriptional regulator
sake_RS02475	COG2197	response regulator
sake_RS02480	COG4585	Histidine kinase
sake_RS02510	COG1254	Belongs to the acylphosphatase family
sake_RS02530	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
sake_RS02545	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
sake_RS02555	COG0022	dehydrogenase e1 component
sake_RS02560	COG0508	dehydrogenase complex catalyzes the overall conversion of
sake_RS02570	COG0110	maltose O-acetyltransferase activity
sake_RS02580	COG0318	PFAM AMP-dependent synthetase and ligase
sake_RS02590	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
sake_RS02595	COG1464	Belongs to the NlpA lipoprotein family
sake_RS02610	COG1063	alcohol dehydrogenase
sake_RS02615	COG2376	Dihydroxyacetone kinase
sake_RS02625	COG1070	Carbohydrate kinase
sake_RS02630	COG1028	Short-chain dehydrogenase reductase Sdr
sake_RS02635	COG1070	Carbohydrate kinase
sake_RS02645	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
sake_RS02655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
sake_RS02660	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
sake_RS02665	COG1120	ATPase activity
sake_RS02680	COG0227	Belongs to the bacterial ribosomal protein bL28 family
sake_RS02685	COG0267	Belongs to the bacterial ribosomal protein bL33 family
sake_RS02690	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
sake_RS02695	COG0776	regulation of translation
sake_RS02710	COG2847	Copper chaperone PCu(A)C
sake_RS02720	COG3336	cytochrome c oxidase
sake_RS02750	COG0717	Belongs to the dCTP deaminase family
sake_RS02770	COG2111	Na H antiporter
sake_RS02770	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
sake_RS02790	COG2212	antiporter activity
sake_RS02795	COG1320	monovalent cation:proton antiporter activity
sake_RS02805	COG4721	ABC-type cobalt transport system, permease component
sake_RS02810	COG1122	ATPase activity
sake_RS02820	COG0577	efflux transmembrane transporter activity
sake_RS02820	COG1136	(ABC) transporter
sake_RS02825	COG0577	efflux transmembrane transporter activity
sake_RS02845	COG2814	Major facilitator Superfamily
sake_RS02855	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
sake_RS02870	COG0443	Heat shock 70 kDa protein
sake_RS02875	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
sake_RS02880	COG0484	heat shock protein binding
sake_RS02885	COG0789	Transcriptional regulator
sake_RS02890	COG0220	tRNA (guanine-N7-)-methyltransferase activity
sake_RS02895	COG1115	amino acid carrier protein
sake_RS02905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
sake_RS02925	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
sake_RS02935	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
sake_RS02960	COG2814	Major facilitator Superfamily
sake_RS02970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
sake_RS02985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
sake_RS02990	COG0151	Belongs to the GarS family
sake_RS02995	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
sake_RS03000	COG2186	Transcriptional regulator
sake_RS03005	COG1620	l-lactate permease
sake_RS03010	COG0247	lactate metabolic process
sake_RS03015	COG1139	Iron-sulfur cluster binding protein
sake_RS03020	COG1556	Lactate utilization protein
sake_RS03055	COG1064	alcohol dehydrogenase
sake_RS03075	COG1132	(ABC) transporter
sake_RS03080	COG1132	(ABC) transporter
sake_RS03085	COG1408	metallophosphoesterase
sake_RS03090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
sake_RS03100	COG0251	oxidation-reduction process
sake_RS03120	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
sake_RS03125	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
sake_RS03130	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
sake_RS03185	COG1205	dead DEAH box helicase
sake_RS03185	COG1111	helicase
sake_RS03200	COG0435	Glutathione S-transferase
sake_RS03205	COG2890	protein-(glutamine-N5) methyltransferase activity
sake_RS03210	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
sake_RS03210	COG1754	DNA topoisomerase type I activity
sake_RS03215	COG0248	Ppx GppA phosphatase
sake_RS03220	COG1082	Xylose isomerase domain protein TIM barrel
sake_RS03235	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
sake_RS03240	COG0123	including yeast histone deacetylase and acetoin utilization protein
sake_RS03245	COG0640	Transcriptional regulator
sake_RS03265	COG0406	alpha-ribazole phosphatase activity
sake_RS03275	COG0785	Cytochrome C biogenesis protein
sake_RS03285	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
sake_RS03305	COG2807	transmembrane transport
sake_RS03320	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
sake_RS03325	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
sake_RS03335	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
sake_RS03350	COG4948	Mandelate Racemase Muconate Lactonizing
sake_RS03360	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
sake_RS03385	COG1120	ATPase activity
sake_RS03390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
sake_RS03395	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
sake_RS03400	COG2409	Drug exporters of the RND superfamily
sake_RS03405	COG1309	transcriptional regulator
sake_RS03410	COG2409	Drug exporters of the RND superfamily
sake_RS03420	COG2226	methyltransferase
sake_RS03460	COG0667	Aldo Keto reductase
sake_RS03470	COG2814	Major facilitator Superfamily
sake_RS03525	COG0501	Belongs to the peptidase M48B family
sake_RS03530	COG1666	GTP binding
sake_RS03545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
sake_RS03575	COG2030	dehydratase
sake_RS03585	COG0738	Major facilitator superfamily
sake_RS03590	COG0812	UDP-N-acetylmuramate dehydrogenase activity
sake_RS03605	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
sake_RS03615	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
sake_RS03625	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
sake_RS03630	COG0745	RESPONSE REGULATOR receiver
sake_RS03640	COG3485	protocatechuate 3,4-dioxygenase
sake_RS03650	COG0205	6-phosphofructokinase activity
sake_RS03655	COG0436	Aminotransferase
sake_RS03670	COG0250	Participates in transcription elongation, termination and antitermination
sake_RS03675	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
sake_RS03680	COG0081	regulation of translation
sake_RS03685	COG3842	ATPase activity
sake_RS03690	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
sake_RS03695	COG0222	ribosome binding
sake_RS03700	COG0303	'Molybdopterin
sake_RS03735	COG0315	cyclic pyranopterin monophosphate synthase activity
sake_RS03740	COG0521	Mo-molybdopterin cofactor biosynthetic process
sake_RS03750	COG0477	Major facilitator Superfamily
sake_RS03755	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
sake_RS03755	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
sake_RS03760	COG0404	The glycine cleavage system catalyzes the degradation of glycine
sake_RS03770	COG0085	RNA polymerase activity
sake_RS03775	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
sake_RS03780	COG3485	protocatechuate 3,4-dioxygenase
sake_RS03785	COG3485	protocatechuate 3,4-dioxygenase
sake_RS03790	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
sake_RS03795	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
sake_RS03800	COG0183	Belongs to the thiolase family
sake_RS03810	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
sake_RS03815	COG1414	Transcriptional regulator
sake_RS03820	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
sake_RS03825	COG0049	tRNA binding
sake_RS03830	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
sake_RS03835	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
sake_RS03850	COG0051	transcription antitermination factor activity, RNA binding
sake_RS03855	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
sake_RS03860	COG0088	Forms part of the polypeptide exit tunnel
sake_RS03865	COG0089	rRNA binding
sake_RS03870	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
sake_RS03875	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
sake_RS03880	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
sake_RS03885	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
sake_RS03890	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
sake_RS03895	COG0255	Belongs to the universal ribosomal protein uL29 family
sake_RS03900	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
sake_RS03905	COG2382	esterase
sake_RS03915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
sake_RS03920	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
sake_RS03925	COG1120	ATPase activity
sake_RS03930	COG4592	Periplasmic binding protein
sake_RS03935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
sake_RS03940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
sake_RS03965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
sake_RS03970	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
sake_RS03985	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
sake_RS03990	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
sake_RS03995	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
sake_RS04000	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
sake_RS04005	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
sake_RS04015	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
sake_RS04020	COG1841	ribosomal large subunit assembly
sake_RS04025	COG0200	Binds to the 23S rRNA
sake_RS04035	COG0563	adenylate kinase activity
sake_RS04045	COG0820	rRNA (adenine-C2-)-methyltransferase activity
sake_RS04050	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
sake_RS04055	COG0257	Belongs to the bacterial ribosomal protein bL36 family
sake_RS04060	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
sake_RS04065	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
sake_RS04070	COG0202	RNA polymerase activity
sake_RS04075	COG0203	ribosomal protein L17
sake_RS04085	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
sake_RS04090	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
sake_RS04095	COG2326	polyphosphate kinase activity
sake_RS04100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
sake_RS04105	COG1970	mechanosensitive ion channel activity
sake_RS04110	COG1072	(Pantothenic acid kinase))
sake_RS04115	COG2213	PTS system mannitol-specific
sake_RS04115	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
sake_RS04120	COG0246	Mannitol dehydrogenase
sake_RS04130	COG0736	holo-[acyl-carrier-protein] synthase activity
sake_RS04135	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
sake_RS04135	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
sake_RS04150	COG0297	glycogen (starch) synthase activity
sake_RS04155	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
sake_RS04160	COG0802	atpase or kinase
sake_RS04170	COG1247	-acetyltransferase
sake_RS04175	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
sake_RS04180	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
sake_RS04190	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
sake_RS04195	COG0459	protein refolding
sake_RS04200	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
sake_RS04200	COG2755	lipolytic protein G-D-S-L family
sake_RS04210	COG0516	GMP reductase activity
sake_RS04225	COG0518	GMP synthase (glutamine-hydrolyzing) activity
sake_RS04225	COG0519	Catalyzes the synthesis of GMP from XMP
sake_RS04245	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
sake_RS04250	COG1210	Utp--glucose-1-phosphate uridylyltransferase
sake_RS04280	COG0668	transmembrane transport
sake_RS04285	COG1051	belongs to the nudix hydrolase family
sake_RS04305	COG1570	exodeoxyribonuclease VII activity
sake_RS04345	COG0012	GTP binding
sake_RS04355	COG1309	transcriptional regulator
sake_RS04390	COG1028	Short-chain dehydrogenase reductase Sdr
sake_RS04410	COG1028	Short-chain dehydrogenase reductase Sdr
sake_RS04415	COG3663	DNA glycosylase
sake_RS04430	COG3158	transport of potassium into the cell
sake_RS04450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
sake_RS04465	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
sake_RS04470	COG0833	amino acid
sake_RS04475	COG2814	Major facilitator Superfamily
sake_RS04480	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
sake_RS04485	COG2838	Isocitrate dehydrogenase
sake_RS04495	COG1051	belongs to the nudix hydrolase family
sake_RS04505	COG0166	Belongs to the GPI family
sake_RS04515	COG4166	transmembrane transport
sake_RS04520	COG0601	transmembrane transport
sake_RS04525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
sake_RS04530	COG4172	Belongs to the ABC transporter superfamily
sake_RS04540	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
sake_RS04560	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
sake_RS04565	COG2171	N-acyltransferase activity
sake_RS04570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
sake_RS04605	COG2239	Acts as a magnesium transporter
sake_RS04615	COG0006	proline dipeptidase activity
sake_RS04625	COG2189	Belongs to the N(4) N(6)-methyltransferase family
sake_RS04640	COG1309	transcriptional regulator
sake_RS04645	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
sake_RS04650	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
sake_RS04670	COG0181	hydroxymethylbilane synthase activity
sake_RS04680	COG0113	porphobilinogen synthase activity
sake_RS04685	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
sake_RS04700	COG0210	DNA helicase
sake_RS04735	COG3480	Lon protease (S16) C-terminal proteolytic domain
sake_RS04740	COG1615	UPF0182 protein
sake_RS04755	COG1842	Phage shock protein A
sake_RS04765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
sake_RS04770	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
sake_RS04780	COG0482	sulfurtransferase activity
sake_RS04785	COG0287	Prephenate dehydrogenase
sake_RS04785	COG1605	Chorismate mutase
sake_RS04795	COG0745	RESPONSE REGULATOR receiver
sake_RS04800	COG5002	protein histidine kinase activity
sake_RS04800	COG5000	phosphorelay sensor kinase activity
sake_RS04805	COG5401	PFAM Sporulation and spore germination
sake_RS04810	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
sake_RS04815	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
sake_RS04820	COG0653	protein targeting
sake_RS04865	COG1216	Glycosyl transferase, family 2
sake_RS04885	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
sake_RS04890	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
sake_RS04905	COG0483	inositol monophosphate 1-phosphatase activity
sake_RS04915	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
sake_RS04925	COG1595	DNA-templated transcription, initiation
sake_RS04940	COG0567	Dehydrogenase, E1 component
sake_RS04940	COG0508	dehydrogenase complex catalyzes the overall conversion of
sake_RS04950	COG1253	flavin adenine dinucleotide binding
sake_RS04955	COG1253	flavin adenine dinucleotide binding
sake_RS04965	COG1121	(ABC) transporter
sake_RS04970	COG1108	ABC-type Mn2 Zn2 transport systems permease components
sake_RS04990	COG1643	Atp-dependent helicase
sake_RS05005	COG0831	urea catabolic process
sake_RS05010	COG0832	Belongs to the urease beta subunit family
sake_RS05015	COG0804	urea catabolic process
sake_RS05020	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
sake_RS05025	COG0830	nickel cation binding
sake_RS05030	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
sake_RS05035	COG0829	nickel cation binding
sake_RS05040	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
sake_RS05050	COG0018	arginyl-trna synthetase
sake_RS05055	COG0019	diaminopimelate decarboxylase activity
sake_RS05060	COG0460	homoserine dehydrogenase
sake_RS05065	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
sake_RS05070	COG0083	homoserine kinase activity
sake_RS05080	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
sake_RS05085	COG2890	protein-(glutamine-N5) methyltransferase activity
sake_RS05090	COG0009	L-threonylcarbamoyladenylate synthase
sake_RS05100	COG1216	Glycosyl transferase, family 2
sake_RS05105	COG1086	Polysaccharide biosynthesis protein
sake_RS05110	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
sake_RS05125	COG0356	it plays a direct role in the translocation of protons across the membrane
sake_RS05130	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
sake_RS05135	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
sake_RS05140	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
sake_RS05145	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
sake_RS05150	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
sake_RS05155	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
sake_RS05160	COG0355	proton-transporting ATP synthase activity, rotational mechanism
sake_RS05165	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
sake_RS05210	COG1335	isochorismatase
sake_RS05220	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
sake_RS05230	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
sake_RS05240	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
sake_RS05245	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
sake_RS05260	COG0420	3'-5' exonuclease activity
sake_RS05265	COG0419	ATPase involved in DNA repair
sake_RS05275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
sake_RS05290	COG1295	ribonuclease BN
sake_RS05300	COG0747	negative chemotaxis
sake_RS05340	COG0440	acetolactate synthase activity
sake_RS05345	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
sake_RS05370	COG0473	3-isopropylmalate dehydrogenase activity
sake_RS05375	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
sake_RS05380	COG0179	Fumarylacetoacetate (FAA) hydrolase
sake_RS05385	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
sake_RS05400	COG1414	Transcriptional regulator
sake_RS05405	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
sake_RS05410	COG0066	3-isopropylmalate dehydratase activity
sake_RS05415	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
sake_RS05425	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
sake_RS05430	COG1181	Belongs to the D-alanine--D-alanine ligase family
sake_RS05445	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
sake_RS05450	COG1461	Dihydroxyacetone kinase
sake_RS05460	COG0742	ribosomal rna small subunit methyltransferase
sake_RS05470	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
sake_RS05480	COG0333	Belongs to the bacterial ribosomal protein bL32 family
sake_RS05485	COG0571	ribonuclease III activity
sake_RS05490	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
sake_RS05510	COG0789	Transcriptional regulator
sake_RS05535	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
sake_RS05550	COG0640	Transcriptional regulator
sake_RS05560	COG2072	flavoprotein involved in K transport
sake_RS05570	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
sake_RS05580	COG2072	flavoprotein involved in K transport
sake_RS05585	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
sake_RS05590	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
sake_RS05595	COG0798	PFAM Bile acid sodium symporter
sake_RS05610	COG1695	Transcriptional regulator
sake_RS05650	COG1937	Protein conserved in bacteria
sake_RS05655	COG2217	Heavy metal translocating P-type atpase
sake_RS05660	COG1388	LysM domain
sake_RS05680	COG2608	mercury ion transmembrane transporter activity
sake_RS05690	COG2132	Multicopper oxidase
sake_RS05695	COG0477	Major facilitator Superfamily
sake_RS05705	COG0640	Transcriptional regulator
sake_RS05715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
sake_RS05720	COG0318	PFAM AMP-dependent synthetase and ligase
sake_RS05725	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
sake_RS05770	COG4585	Histidine kinase
sake_RS05775	COG2197	response regulator
sake_RS05780	COG0228	four-way junction DNA binding
sake_RS05785	COG1837	Belongs to the UPF0109 family
sake_RS05790	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
sake_RS05795	COG0336	Belongs to the RNA methyltransferase TrmD family
sake_RS05800	COG0335	large ribosomal subunit rRNA binding
sake_RS05805	COG0681	Belongs to the peptidase S26 family
sake_RS05810	COG0681	Belongs to the peptidase S26 family
sake_RS05815	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
sake_RS05820	COG0792	nuclease activity
sake_RS05850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
sake_RS05855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
sake_RS05860	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
sake_RS05870	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
sake_RS05885	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
sake_RS05890	COG1045	serine acetyltransferase
sake_RS05900	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
sake_RS05905	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
sake_RS05915	COG3022	response to hydroperoxide
sake_RS05920	COG0242	peptide deformylase activity
sake_RS05925	COG1595	DNA-templated transcription, initiation
sake_RS05935	COG1268	BioY protein
sake_RS05940	COG0318	PFAM AMP-dependent synthetase and ligase
sake_RS05945	COG0183	Belongs to the thiolase family
sake_RS05950	COG1122	ATPase activity
sake_RS05990	COG0629	single-stranded DNA binding
sake_RS06005	COG1946	Acyl-CoA thioesterase
sake_RS06045	COG0544	peptidyl-prolyl cis-trans isomerase activity
sake_RS06050	COG0740	serine-type endopeptidase activity
sake_RS06055	COG0740	serine-type endopeptidase activity
sake_RS06060	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
sake_RS06070	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
sake_RS06080	COG0525	valine-tRNA ligase activity
sake_RS06095	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
sake_RS06110	COG0529	Catalyzes the synthesis of activated sulfate
sake_RS06110	COG2895	sulfate adenylyltransferase (ATP) activity
sake_RS06115	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
sake_RS06115	COG1648	precorrin-2 dehydrogenase activity
sake_RS06125	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
sake_RS06130	COG0285	dihydrofolate synthase activity
sake_RS06145	COG0105	UTP biosynthetic process
sake_RS06155	COG1530	ribonuclease E activity
sake_RS06160	COG0261	This protein binds to 23S rRNA in the presence of protein L20
sake_RS06165	COG0211	Belongs to the bacterial ribosomal protein bL27 family
sake_RS06170	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
sake_RS06175	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
sake_RS06180	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
sake_RS06190	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
sake_RS06200	COG0799	negative regulation of ribosome biogenesis
sake_RS06245	COG0667	Aldo Keto reductase
sake_RS06260	COG1121	(ABC) transporter
sake_RS06265	COG1108	ABC-type Mn2 Zn2 transport systems permease components
sake_RS06270	COG1321	iron dependent repressor
sake_RS06270	COG1108	ABC-type Mn2 Zn2 transport systems permease components
sake_RS06290	COG1780	Probably involved in ribonucleotide reductase function
sake_RS06295	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
sake_RS06300	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
sake_RS06310	COG0659	secondary active sulfate transmembrane transporter activity
sake_RS06340	COG2759	Belongs to the formate--tetrahydrofolate ligase family
sake_RS06365	COG0322	excinuclease ABC activity
sake_RS06370	COG1660	Displays ATPase and GTPase activities
sake_RS06380	COG1481	regulation of sporulation
sake_RS06385	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
sake_RS06390	COG0126	phosphoglycerate kinase activity
sake_RS06395	COG0149	triose-phosphate isomerase activity
sake_RS06400	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
sake_RS06405	COG0363	glucosamine-6-phosphate deaminase activity
sake_RS06420	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
sake_RS06430	COG0109	protoheme IX farnesyltransferase activity
sake_RS06445	COG1131	(ABC) transporter
sake_RS06465	COG0396	ATPase activity
sake_RS06470	COG2151	metal-sulfur cluster biosynthetic enzyme
sake_RS06480	COG0488	(ABC) transporter
sake_RS06500	COG1028	Short-chain dehydrogenase reductase Sdr
sake_RS06505	COG1028	Short-chain dehydrogenase reductase Sdr
sake_RS06510	COG0560	Phosphoserine phosphatase
sake_RS06510	COG3830	Belongs to the UPF0237 family
sake_RS06515	COG1119	ATPase activity
sake_RS06530	COG0254	rRNA binding
sake_RS06535	COG1316	TRANSCRIPTIONal
sake_RS06540	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
sake_RS06565	COG0183	Belongs to the thiolase family
sake_RS06585	COG0039	L-malate dehydrogenase activity
sake_RS06595	COG1968	undecaprenyl-diphosphatase activity
sake_RS06600	COG0215	cysteine-tRNA ligase activity
sake_RS06605	COG0517	IMP dehydrogenase activity
sake_RS06605	COG1994	Peptidase M50
sake_RS06615	COG1222	aaa ATPase
sake_RS06620	COG4122	O-methyltransferase activity
sake_RS06630	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
sake_RS06635	COG0545	Peptidyl-prolyl cis-trans isomerase
sake_RS06655	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
sake_RS06660	COG0805	protein transport
sake_RS06670	COG1228	amidohydrolase
sake_RS06675	COG0463	Glycosyl transferase, family 2
sake_RS06700	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
sake_RS06705	COG1845	cytochrome c oxidase, subunit III
sake_RS06710	COG2010	Cytochrome c
sake_RS06715	COG0723	plastoquinol--plastocyanin reductase activity
sake_RS06720	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
sake_RS06730	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
sake_RS06735	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
sake_RS06745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
sake_RS06755	COG0167	dihydroorotate dehydrogenase activity
sake_RS06760	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
sake_RS06765	COG1381	Involved in DNA repair and RecF pathway recombination
sake_RS06770	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
sake_RS06775	COG1316	TRANSCRIPTIONal
sake_RS06780	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
sake_RS06790	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
sake_RS06810	COG0484	heat shock protein binding
sake_RS06815	COG1420	regulation of RNA biosynthetic process
sake_RS06835	COG0481	GTPase activity
sake_RS06845	COG0268	Binds directly to 16S ribosomal RNA
sake_RS06870	COG1228	amidohydrolase
sake_RS06875	COG1028	Short-chain dehydrogenase reductase Sdr
sake_RS06885	COG0583	DNA-binding transcription factor activity
sake_RS06910	COG1596	polysaccharide export
sake_RS06910	COG1555	photosystem II stabilization
sake_RS06915	COG1307	EDD domain protein, DegV family
sake_RS06920	COG0495	leucyl-tRNA aminoacylation
sake_RS06940	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
sake_RS06950	COG1758	RNA polymerase activity
sake_RS06955	COG0194	GDP metabolic process
sake_RS06960	COG0194	GDP metabolic process
sake_RS06965	COG0284	orotidine-5'-phosphate decarboxylase activity
sake_RS06970	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
sake_RS06985	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
sake_RS06990	COG0540	Belongs to the ATCase OTCase family
sake_RS06995	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
sake_RS07000	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
sake_RS07005	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
sake_RS07010	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
sake_RS07020	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
sake_RS07025	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
sake_RS07040	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
sake_RS07055	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
sake_RS07070	COG1490	D-aminoacyl-tRNA deacylase activity
sake_RS07080	COG1902	pentaerythritol trinitrate reductase activity
sake_RS07080	COG0446	pyridine nucleotide-disulphide oxidoreductase
sake_RS07085	COG1028	Short-chain dehydrogenase reductase Sdr
sake_RS07090	COG1960	acyl-CoA dehydrogenase activity
sake_RS07095	COG0318	PFAM AMP-dependent synthetase and ligase
sake_RS07100	COG0477	Major facilitator Superfamily
sake_RS07115	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
sake_RS07125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
sake_RS07190	COG0477	Major facilitator Superfamily
sake_RS07195	COG0477	Major facilitator Superfamily
sake_RS07210	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
sake_RS07210	COG1017	nitric oxide dioxygenase activity
sake_RS07215	COG1959	2 iron, 2 sulfur cluster binding
sake_RS07225	COG0531	amino acid
sake_RS07235	COG3959	Transketolase, thiamine diphosphate binding domain
sake_RS07245	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
sake_RS07255	COG1574	metal-dependent hydrolase with the TIM-barrel fold
sake_RS07260	COG0477	Major facilitator Superfamily
sake_RS07270	COG1012	belongs to the aldehyde dehydrogenase family
sake_RS07275	COG1960	acyl-CoA dehydrogenase activity
sake_RS07280	COG1024	Enoyl-CoA hydratase
sake_RS07285	COG1804	L-carnitine dehydratase bile acid-inducible protein F
sake_RS07290	COG0583	DNA-binding transcription factor activity
sake_RS07300	COG1063	alcohol dehydrogenase
sake_RS07310	COG0583	DNA-binding transcription factor activity
sake_RS07315	COG0477	Major facilitator Superfamily
sake_RS07320	COG1053	succinate dehydrogenase
sake_RS07325	COG0673	inositol 2-dehydrogenase activity
sake_RS07345	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
sake_RS07350	COG1368	sulfuric ester hydrolase activity
sake_RS07360	COG0673	inositol 2-dehydrogenase activity
sake_RS07400	COG2252	PERMEase
sake_RS07405	COG0402	S-adenosylhomocysteine deaminase activity
sake_RS07410	COG2233	PERMEase
sake_RS07420	COG1529	Aldehyde oxidase and xanthine dehydrogenase
sake_RS07450	COG2351	hydroxyisourate hydrolase activity
sake_RS07460	COG2233	PERMEase
sake_RS07465	COG1414	Transcriptional regulator
sake_RS07485	COG3257	ureidoglycine aminohydrolase activity
sake_RS07490	COG3622	Belongs to the hyi family
sake_RS07495	COG2084	Dehydrogenase
sake_RS07500	COG3960	tartronate-semialdehyde synthase activity
sake_RS07505	COG1929	Belongs to the glycerate kinase type-1 family
sake_RS07510	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
sake_RS07525	COG1335	isochorismatase
sake_RS07545	COG1136	(ABC) transporter
sake_RS07550	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
sake_RS07555	COG0124	histidyl-tRNA synthetase
sake_RS07560	COG1196	nuclear chromosome segregation
sake_RS07570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
sake_RS07580	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
sake_RS07590	COG2255	four-way junction helicase activity
sake_RS07595	COG0632	four-way junction helicase activity
sake_RS07600	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
sake_RS07605	COG0217	transcriptional regulatory protein
sake_RS07640	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
sake_RS07645	COG0156	8-amino-7-oxononanoate synthase activity
sake_RS07650	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
sake_RS07660	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
sake_RS07675	COG1741	Belongs to the pirin family
sake_RS07685	COG0587	DNA-directed DNA polymerase activity
sake_RS07695	COG0477	Major facilitator Superfamily
sake_RS07705	COG0583	DNA-binding transcription factor activity
sake_RS07720	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
sake_RS07725	COG2223	nitrite transmembrane transporter activity
sake_RS07730	COG1028	Short-chain dehydrogenase reductase Sdr
sake_RS07735	COG0277	FAD linked oxidase domain protein
sake_RS07740	COG1070	Carbohydrate kinase
sake_RS07745	COG2188	Transcriptional regulator
sake_RS07760	COG3037	sugar-specific permease SgaT UlaA
sake_RS07775	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
sake_RS07810	COG0318	PFAM AMP-dependent synthetase and ligase
sake_RS07815	COG2271	Major facilitator Superfamily
sake_RS07825	COG1733	regulation of RNA biosynthetic process
sake_RS07835	COG0556	nucleotide-excision repair
sake_RS07845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
sake_RS07850	COG2186	Transcriptional regulator
sake_RS07855	COG2610	gluconate transmembrane transporter activity
sake_RS07865	COG2084	Dehydrogenase
sake_RS07870	COG0237	dephospho-CoA kinase activity
sake_RS07875	COG1739	Uncharacterized protein family UPF0029
sake_RS07880	COG0539	negative regulation of cytoplasmic translation
sake_RS07895	COG2050	protein possibly involved in aromatic compounds catabolism
sake_RS07950	COG0469	pyruvate kinase activity
sake_RS07965	COG0067	glutamate synthase
sake_RS07965	COG0070	glutamate synthase
sake_RS07965	COG0069	glutamate synthase activity
sake_RS07975	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
sake_RS07980	COG0159	tryptophan synthase activity
sake_RS07985	COG0133	tryptophan synthase activity
sake_RS07990	COG0134	indole-3-glycerol-phosphate synthase activity
sake_RS08010	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
sake_RS08020	COG0107	imidazoleglycerol-phosphate synthase activity
sake_RS08025	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
sake_RS08030	COG0140	phosphoribosyl-ATP diphosphatase activity
sake_RS08035	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
sake_RS08040	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
sake_RS08040	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
sake_RS08045	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
sake_RS08045	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
sake_RS08060	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
sake_RS08080	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
sake_RS08085	COG0242	peptide deformylase activity
sake_RS08125	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
sake_RS08140	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
sake_RS08150	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
sake_RS08160	COG0723	plastoquinol--plastocyanin reductase activity
sake_RS08165	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
sake_RS08170	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
sake_RS08175	COG0531	amino acid
sake_RS08180	COG0569	domain protein
sake_RS08205	COG0756	dUTP diphosphatase activity
sake_RS08245	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
sake_RS08265	COG4988	ABC transporter
sake_RS08270	COG1294	oxidase, subunit
sake_RS08275	COG1271	oxidase subunit
sake_RS08280	COG0039	L-malate dehydrogenase activity
sake_RS08285	COG0187	DNA topoisomerase II activity
sake_RS08295	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
sake_RS08310	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
sake_RS08315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
sake_RS08320	COG0508	dehydrogenase complex catalyzes the overall conversion of
sake_RS08335	COG0321	lipoyl(octanoyl) transferase activity
sake_RS08340	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
sake_RS08355	COG0174	glutamine synthetase
sake_RS08365	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
sake_RS08370	COG0174	glutamine synthetase
sake_RS08375	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
sake_RS08390	COG1940	carbohydrate kinase activity
sake_RS08395	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
sake_RS08400	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
sake_RS08405	COG0587	DNA-directed DNA polymerase activity
sake_RS08415	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
sake_RS08430	COG1799	cell septum assembly
sake_RS08435	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
sake_RS08445	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
sake_RS08450	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
sake_RS08455	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
sake_RS08460	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
sake_RS08470	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
sake_RS08475	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
sake_RS08485	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
sake_RS08490	COG0768	penicillin binding
sake_RS08500	COG0275	rRNA processing
sake_RS08505	COG2001	Belongs to the MraZ family
sake_RS08515	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
sake_RS08535	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
sake_RS08580	COG1716	ATPase activity
sake_RS08585	COG0509	glycine decarboxylation via glycine cleavage system
sake_RS08590	COG1012	belongs to the aldehyde dehydrogenase family
sake_RS08600	COG2390	Transcriptional regulator
sake_RS08605	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
sake_RS08610	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
sake_RS08615	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
sake_RS08625	COG2818	Glycosylase
sake_RS08635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
sake_RS08640	COG2814	Major facilitator Superfamily
sake_RS08645	COG1846	Transcriptional regulator
sake_RS08655	COG0384	phenazine biosynthesis protein PhzF
sake_RS08660	COG2130	NADP-dependent
sake_RS08675	COG0492	ferredoxin-NADP+ reductase activity
sake_RS08690	COG0477	Major facilitator Superfamily
sake_RS08700	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
sake_RS08700	COG2169	Transcriptional regulator
sake_RS08710	COG0514	ATP-dependent DNA helicase (RecQ)
sake_RS08720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
sake_RS08745	COG1160	GTP binding
sake_RS08750	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
sake_RS08765	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
sake_RS08770	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
sake_RS08780	COG1301	dicarboxylic acid transport
sake_RS08785	COG4191	Histidine kinase
sake_RS08790	COG4565	transcriptional regulatory protein
sake_RS08805	COG2079	MmgE PrpD family protein
sake_RS08810	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
sake_RS08820	COG2837	iron assimilation
sake_RS08835	COG0494	nUDIX hydrolase
sake_RS08850	COG1136	(ABC) transporter
sake_RS08850	COG0577	efflux transmembrane transporter activity
sake_RS08870	COG0504	CTP synthase activity
sake_RS08875	COG0497	DNA recombination
sake_RS08880	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
sake_RS08895	COG0647	UMP catabolic process
sake_RS08910	COG1804	L-carnitine dehydratase bile acid-inducible protein F
sake_RS08930	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
sake_RS08940	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
sake_RS08945	COG0165	Argininosuccinate lyase
sake_RS08950	COG0137	argininosuccinate synthase activity
sake_RS08960	COG1438	arginine binding
sake_RS08965	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
sake_RS08970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
sake_RS08975	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
sake_RS08980	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
sake_RS08985	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
sake_RS09000	COG0072	phenylalanine-tRNA ligase activity
sake_RS09000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
sake_RS09005	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
sake_RS09025	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
sake_RS09030	COG0291	Belongs to the bacterial ribosomal protein bL35 family
sake_RS09035	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
sake_RS09050	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
sake_RS09060	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
sake_RS09065	COG0131	Imidazoleglycerol-phosphate dehydratase
sake_RS09070	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
sake_RS09080	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
sake_RS09090	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
sake_RS09095	COG2813	Specifically methylates the guanine in position
sake_RS09100	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
sake_RS09105	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
sake_RS09110	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
sake_RS09120	COG2137	regulation of response to DNA damage stimulus
sake_RS09125	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
sake_RS09135	COG1396	sequence-specific DNA binding
sake_RS09140	COG1058	Belongs to the CinA family
sake_RS09140	COG1546	Belongs to the CinA family
sake_RS09150	COG1674	ftsk spoiiie
sake_RS09160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
sake_RS09170	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
sake_RS09175	COG2755	lipolytic protein G-D-S-L family
sake_RS09175	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
sake_RS09195	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
sake_RS09195	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
sake_RS09205	COG1021	2,3-dihydroxybenzoate-AMP ligase
sake_RS09210	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
sake_RS09215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
sake_RS09220	COG4558	Periplasmic binding protein
sake_RS09225	COG1132	(ABC) transporter
sake_RS09230	COG1819	glycosyl
sake_RS09240	COG3433	isochorismatase activity
sake_RS09240	COG1535	isochorismatase
sake_RS09245	COG1028	Short-chain dehydrogenase reductase Sdr
sake_RS09250	COG1169	isochorismate synthase
sake_RS09265	COG4948	Mandelate Racemase Muconate Lactonizing
sake_RS09280	COG0612	Peptidase, M16
sake_RS09285	COG1185	polyribonucleotide nucleotidyltransferase activity
sake_RS09290	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
sake_RS09295	COG2094	Belongs to the DNA glycosylase MPG family
sake_RS09300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
sake_RS09305	COG4106	trans-aconitate 2-methyltransferase activity
sake_RS09325	COG1854	S-ribosylhomocysteine lyase activity
sake_RS09330	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
sake_RS09335	COG0656	L-ascorbic acid biosynthetic process
sake_RS09360	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
sake_RS09365	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
sake_RS09370	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
sake_RS09385	COG0779	Required for maturation of 30S ribosomal subunits
sake_RS09400	COG0442	prolyl-tRNA aminoacylation
sake_RS09410	COG0750	zinc metalloprotease
sake_RS09415	COG1132	(ABC) transporter
sake_RS09430	COG0233	cytoplasmic translational termination
sake_RS09435	COG0528	UMP kinase activity
sake_RS09440	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
sake_RS09445	COG0052	Belongs to the universal ribosomal protein uS2 family
sake_RS09515	COG5280	Phage tail tape measure protein TP901
sake_RS09515	COG3953	SLT domain
sake_RS09745	COG0438	transferase activity, transferring glycosyl groups
sake_RS09780	COG1028	Short-chain dehydrogenase reductase Sdr
sake_RS09795	COG0423	glycine-tRNA ligase activity
sake_RS09815	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
sake_RS09820	COG2873	o-acetylhomoserine
sake_RS09835	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
sake_RS09840	COG0154	amidase activity
sake_RS09845	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
sake_RS09855	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
sake_RS09860	COG0631	protein serine/threonine phosphatase activity
sake_RS09875	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
sake_RS09875	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
sake_RS09885	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
sake_RS09905	COG1012	belongs to the aldehyde dehydrogenase family
sake_RS09910	COG0424	maF-like protein
sake_RS09915	COG4770	biotin carboxylase activity
sake_RS09920	COG0477	Major facilitator Superfamily
sake_RS09935	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
sake_RS09960	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
sake_RS09965	COG0822	iron-sulfur transferase activity
sake_RS09975	COG0193	aminoacyl-tRNA hydrolase activity
sake_RS09980	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
sake_RS09990	COG1088	dTDP-glucose 4,6-dehydratase activity
sake_RS10025	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
sake_RS10035	COG0438	transferase activity, transferring glycosyl groups
sake_RS10040	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
sake_RS10045	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
sake_RS10055	COG0488	(ABC) transporter
sake_RS10060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
sake_RS10060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
sake_RS10085	COG0477	Major facilitator Superfamily
sake_RS10095	COG2986	histidine ammonia-lyase
sake_RS10110	COG2186	Transcriptional regulator
sake_RS10125	COG1472	Belongs to the glycosyl hydrolase 3 family
sake_RS10130	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
sake_RS10135	COG0084	hydrolase, TatD family'
sake_RS10155	COG1376	ErfK ybiS ycfS ynhG family protein
sake_RS10180	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
sake_RS10190	COG1316	TRANSCRIPTIONal
sake_RS10215	COG0288	reversible hydration of carbon dioxide
sake_RS10220	COG0114	fumarate hydratase activity
sake_RS10235	COG0028	Belongs to the TPP enzyme family
sake_RS10250	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
sake_RS10265	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
sake_RS10275	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
sake_RS10280	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
sake_RS10300	COG1252	NADH dehydrogenase
sake_RS10325	COG0148	phosphopyruvate hydratase activity
sake_RS10330	COG3956	TIGRFAM MazG family protein
sake_RS10335	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
sake_RS10370	COG1744	ABC transporter substrate-binding protein PnrA-like
sake_RS10375	COG1473	amidohydrolase
sake_RS10375	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
sake_RS10380	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
sake_RS10395	COG2009	succinate dehydrogenase
sake_RS10410	COG0180	Tryptophanyl-tRNA synthetase
sake_RS10425	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
sake_RS10430	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
sake_RS10440	COG0385	Bile acid
sake_RS10445	COG3265	gluconokinase activity
sake_RS10450	COG4948	Mandelate Racemase Muconate Lactonizing
sake_RS10460	COG3250	beta-galactosidase activity
sake_RS10465	COG0246	Mannitol dehydrogenase
sake_RS10470	COG1904	glucuronate isomerase
sake_RS10500	COG0667	Aldo Keto reductase
sake_RS10515	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
sake_RS10515	COG0438	transferase activity, transferring glycosyl groups
sake_RS10530	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
sake_RS10535	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
sake_RS10540	COG1012	belongs to the aldehyde dehydrogenase family
sake_RS10555	COG0656	L-ascorbic acid biosynthetic process
sake_RS10565	COG2814	Major facilitator Superfamily
sake_RS10575	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
sake_RS10585	COG0045	succinate-CoA ligase (ADP-forming) activity
sake_RS10590	COG0477	Major facilitator Superfamily
sake_RS10635	COG1388	LysM domain
sake_RS10635	COG3103	Sh3 type 3 domain protein
sake_RS10635	COG0791	NLP P60 protein
sake_RS10640	COG1435	thymidine kinase activity
sake_RS10645	COG1321	iron dependent repressor
sake_RS10650	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
sake_RS10655	COG2814	Major facilitator Superfamily
sake_RS10665	COG1278	Cold shock
sake_RS10675	COG0745	RESPONSE REGULATOR receiver
sake_RS10680	COG2205	protein histidine kinase activity
sake_RS10690	COG0328	RNA-DNA hybrid ribonuclease activity
sake_RS10695	COG1169	isochorismate synthase
sake_RS10710	COG0459	protein refolding
sake_RS10745	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
sake_RS10750	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
sake_RS10750	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
sake_RS10755	COG1105	Belongs to the carbohydrate kinase PfkB family
sake_RS10760	COG1349	DNA-binding transcription factor activity
sake_RS10765	COG0588	phosphoglycerate mutase activity
sake_RS10780	COG1028	Short-chain dehydrogenase reductase Sdr
sake_RS10795	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
sake_RS10815	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
sake_RS10820	COG0215	cysteine-tRNA ligase activity
sake_RS10825	COG1329	Transcriptional regulator
sake_RS10840	COG5002	protein histidine kinase activity
sake_RS10850	COG0588	phosphoglycerate mutase activity
sake_RS10865	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
sake_RS10870	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
sake_RS10875	COG2848	UPF0210 protein
sake_RS10885	COG0628	permease
sake_RS10890	COG1482	cell wall glycoprotein biosynthetic process
sake_RS10895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
sake_RS10900	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
sake_RS10930	COG0778	Nitroreductase
sake_RS10940	COG1201	RNA secondary structure unwinding
sake_RS10945	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
sake_RS10950	COG0531	amino acid
sake_RS10955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
sake_RS10980	COG0343	queuine tRNA-ribosyltransferase activity
sake_RS11010	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
sake_RS11025	COG0367	asparagine synthase
sake_RS11040	COG2239	Acts as a magnesium transporter
sake_RS11065	COG1846	Transcriptional regulator
sake_RS11070	COG1764	response to oxidative stress
sake_RS11130	COG2022	thiamine diphosphate biosynthetic process
sake_RS11145	COG0352	thiamine-phosphate diphosphorylase activity
sake_RS11150	COG1012	belongs to the aldehyde dehydrogenase family
sake_RS11185	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
sake_RS11215	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
sake_RS11230	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
sake_RS11245	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
sake_RS11250	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
sake_RS11280	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
sake_RS11285	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
sake_RS11290	COG0302	gtp cyclohydrolase
sake_RS11295	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
sake_RS11305	COG0037	tRNA processing
sake_RS11315	COG2027	D-alanyl-D-alanine carboxypeptidase
sake_RS11320	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
sake_RS11330	COG0531	amino acid
sake_RS11340	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
sake_RS11345	COG1012	belongs to the aldehyde dehydrogenase family
sake_RS11350	COG1028	Short-chain dehydrogenase reductase Sdr
sake_RS11355	COG1473	amidohydrolase
sake_RS11375	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
sake_RS11380	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
sake_RS11385	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
sake_RS11390	COG1263	PTS System
sake_RS11390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
sake_RS11395	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
sake_RS11400	COG1737	Transcriptional regulator
sake_RS11405	COG1780	Probably involved in ribonucleotide reductase function
sake_RS11410	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
sake_RS11415	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
sake_RS11420	COG1263	PTS System
sake_RS11425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
sake_RS11430	COG2188	Transcriptional regulator
sake_RS11445	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
sake_RS11455	COG0363	glucosamine-6-phosphate deaminase activity
sake_RS11460	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
sake_RS11465	COG1940	carbohydrate kinase activity
sake_RS11470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
sake_RS11475	COG4608	Belongs to the ABC transporter superfamily
sake_RS11480	COG0444	Belongs to the ABC transporter superfamily
sake_RS11490	COG4166	transmembrane transport
sake_RS11495	COG2188	Transcriptional regulator
sake_RS11505	COG1216	Glycosyl transferase, family 2
sake_RS11510	COG1732	Glycine betaine
sake_RS11515	COG1174	glycine betaine transport
sake_RS11525	COG1174	glycine betaine transport
sake_RS11535	COG1832	CoA-binding protein
sake_RS11545	COG2814	Major facilitator Superfamily
sake_RS11585	COG0129	dihydroxy-acid dehydratase activity
sake_RS11595	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
sake_RS11620	COG2190	(PTS) system
sake_RS11620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
sake_RS11620	COG1263	PTS System
sake_RS11630	COG0183	Belongs to the thiolase family
sake_RS11635	COG0598	Magnesium transport protein CorA
sake_RS11640	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
sake_RS11650	COG0686	Belongs to the AlaDH PNT family
sake_RS11680	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
sake_RS11685	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
sake_RS11685	COG0512	Glutamine amidotransferase of anthranilate synthase
sake_RS11690	COG0069	glutamate synthase activity
sake_RS11695	COG1960	acyl-CoA dehydrogenase activity
sake_RS11700	COG0318	PFAM AMP-dependent synthetase and ligase
sake_RS11705	COG0183	Belongs to the thiolase family
sake_RS11715	COG1960	acyl-CoA dehydrogenase activity
sake_RS11725	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
sake_RS11745	COG1024	Enoyl-CoA hydratase
sake_RS11755	COG1024	Enoyl-CoA hydratase
sake_RS11780	COG2226	methyltransferase
sake_RS11785	COG0656	L-ascorbic acid biosynthetic process
sake_RS11800	COG1063	alcohol dehydrogenase
sake_RS11810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
sake_RS11855	COG2072	flavoprotein involved in K transport
sake_RS11860	COG0583	DNA-binding transcription factor activity
sake_RS11890	COG3590	peptidase
sake_RS11900	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
sake_RS11905	COG5650	phosphatidylinositol metabolic process
sake_RS11930	COG1012	belongs to the aldehyde dehydrogenase family
sake_RS11945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
sake_RS11955	COG3001	Fructosamine kinase
sake_RS11960	COG0584	glycerophosphoryl diester phosphodiesterase
sake_RS11970	COG1396	sequence-specific DNA binding
sake_RS11995	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
sake_RS12000	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
sake_RS12010	COG2814	Major facilitator Superfamily
sake_RS12015	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
sake_RS12045	COG1012	belongs to the aldehyde dehydrogenase family
sake_RS12050	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
sake_RS12055	COG1063	alcohol dehydrogenase
sake_RS12090	COG3290	protein histidine kinase activity
sake_RS12125	COG2186	Transcriptional regulator
sake_RS12130	COG2851	Citrate transporter
sake_RS12140	COG0352	thiamine-phosphate diphosphorylase activity
sake_RS12140	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
sake_RS12140	COG0351	phosphomethylpyrimidine kinase
sake_RS12145	COG0351	phosphomethylpyrimidine kinase
sake_RS12150	COG0352	thiamine-phosphate diphosphorylase activity
sake_RS12160	COG0259	pyridoxamine-phosphate oxidase activity
sake_RS12195	COG2188	Transcriptional regulator
sake_RS12205	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
sake_RS12215	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
sake_RS12215	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
sake_RS12255	COG2610	gluconate transmembrane transporter activity
sake_RS12260	COG1115	amino acid carrier protein
sake_RS12265	COG5479	isomerase activity
sake_RS12265	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
sake_RS12280	COG1113	amino acid transport
sake_RS12285	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
sake_RS12325	COG2957	Belongs to the agmatine deiminase family
sake_RS12335	COG1028	Short-chain dehydrogenase reductase Sdr
sake_RS12345	COG1960	acyl-CoA dehydrogenase activity
sake_RS12360	COG0477	Major facilitator Superfamily
sake_RS12415	COG0789	Transcriptional regulator
sake_RS12425	COG1404	Belongs to the peptidase S8 family
sake_RS12435	COG3971	2-oxopent-4-enoate hydratase activity
sake_RS12445	COG1012	belongs to the aldehyde dehydrogenase family
sake_RS12450	COG1802	Transcriptional regulator
sake_RS12455	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
sake_RS12460	COG0477	Major facilitator Superfamily
sake_RS12465	COG0531	amino acid
sake_RS12475	COG1073	alpha beta
sake_RS12500	COG1473	amidohydrolase
sake_RS12510	COG1012	belongs to the aldehyde dehydrogenase family
sake_RS12520	COG0277	FAD linked oxidase domain protein
sake_RS12525	COG2902	Dehydrogenase
sake_RS12530	COG2149	membrane
sake_RS12540	COG2902	Dehydrogenase
sake_RS12565	COG0463	Glycosyl transferase, family 2
sake_RS12600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
sake_RS12605	COG1113	amino acid transport
sake_RS12610	COG2272	Belongs to the type-B carboxylesterase lipase family
sake_RS12620	COG0477	Major facilitator Superfamily
sake_RS12625	COG0252	asparaginase activity
sake_RS12635	COG2860	membrane
sake_RS12640	COG3422	double-strand break repair
sake_RS12650	COG0667	Aldo Keto reductase
sake_RS12660	COG0477	Major facilitator Superfamily
sake_RS12665	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
sake_RS12690	COG0477	Major facilitator Superfamily
sake_RS12695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
sake_RS12710	COG2197	response regulator
sake_RS12715	COG4585	Histidine kinase
sake_RS12735	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
sake_RS12770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
sake_RS12780	COG0477	Major facilitator Superfamily
sake_RS12795	COG0477	Major facilitator Superfamily
sake_RS12805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
sake_RS12815	COG0477	Major facilitator Superfamily
sake_RS12820	COG1335	isochorismatase
sake_RS12825	COG0076	glutamate decarboxylase activity
sake_RS12830	COG3486	L-lysine 6-monooxygenase (NADPH) activity
sake_RS12850	COG3540	Alkaline phosphatase
sake_RS12865	COG2391	methyltransferase activity
sake_RS12870	COG2814	Major facilitator Superfamily
sake_RS12900	COG2318	DinB family
sake_RS12905	COG1113	amino acid transport
sake_RS12925	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
sake_RS12930	COG4221	oxidoreductase activity
sake_RS12935	COG0257	Belongs to the bacterial ribosomal protein bL36 family
sake_RS12945	COG0477	Major facilitator Superfamily
sake_RS12950	COG1473	amidohydrolase
sake_RS12965	COG2159	amidohydrolase
sake_RS12975	COG0477	Major facilitator Superfamily
sake_RS12975	COG2814	Major facilitator Superfamily
sake_RS12990	COG2814	Major facilitator Superfamily
sake_RS13005	COG0667	Aldo Keto reductase
sake_RS13015	COG0305	Participates in initiation and elongation during chromosome replication
sake_RS13020	COG1929	Belongs to the glycerate kinase type-1 family
sake_RS13030	COG0359	binds to the 23S rRNA
sake_RS13035	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
sake_RS13045	COG0360	Binds together with S18 to 16S ribosomal RNA
sake_RS13060	COG1131	(ABC) transporter
sake_RS13085	COG0492	ferredoxin-NADP+ reductase activity
sake_RS13090	COG3118	belongs to the thioredoxin family
sake_RS13095	COG1475	DNA binding
sake_RS13100	COG1192	Involved in chromosome partitioning
sake_RS13105	COG0357	Ribosomal RNA small subunit methyltransferase G
sake_RS13110	COG1847	R3H domain protein
sake_RS13115	COG0706	membrane insertase activity
sake_RS13120	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
sake_RS13125	COG0594	ribonuclease P activity
sake_RS13130	COG0230	Belongs to the bacterial ribosomal protein bL34 family
sake_RS13150	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
sake_RS13180	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
sake_RS13185	COG0798	PFAM Bile acid sodium symporter
sake_RS13190	COG2072	flavoprotein involved in K transport
sake_RS13205	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
sake_RS13240	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
sake_RS13280	COG1002	Type II restriction enzyme, methylase subunits