locus-tag	class	description
ICJ78_RS00020	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ICJ78_RS00025	COG3047	cAMP biosynthetic process
ICJ78_RS00035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ICJ78_RS00050	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ICJ78_RS00055	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
ICJ78_RS00065	COG0535	radical SAM domain protein
ICJ78_RS00070	COG2205	protein histidine kinase activity
ICJ78_RS00075	COG0745	RESPONSE REGULATOR receiver
ICJ78_RS00085	COG0443	Heat shock 70 kDa protein
ICJ78_RS00090	COG0484	heat shock protein binding
ICJ78_RS00095	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ICJ78_RS00100	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ICJ78_RS00110	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ICJ78_RS00115	COG1028	Short-chain dehydrogenase reductase Sdr
ICJ78_RS00130	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ICJ78_RS00130	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ICJ78_RS00140	COG2814	Major facilitator Superfamily
ICJ78_RS00145	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ICJ78_RS00150	COG1024	Enoyl-CoA hydratase
ICJ78_RS00155	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ICJ78_RS00165	COG0735	belongs to the Fur family
ICJ78_RS00175	COG2814	Major facilitator Superfamily
ICJ78_RS00180	COG0285	dihydrofolate synthase activity
ICJ78_RS00185	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ICJ78_RS00190	COG0159	tryptophan synthase activity
ICJ78_RS00195	COG0133	tryptophan synthase activity
ICJ78_RS00220	COG0438	transferase activity, transferring glycosyl groups
ICJ78_RS00225	COG0438	transferase activity, transferring glycosyl groups
ICJ78_RS00225	COG1216	Glycosyl transferase, family 2
ICJ78_RS00235	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ICJ78_RS00245	COG2942	2-epimerase
ICJ78_RS00285	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ICJ78_RS00315	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ICJ78_RS00320	COG0445	tRNA wobble uridine modification
ICJ78_RS00325	COG0357	Ribosomal RNA small subunit methyltransferase G
ICJ78_RS00345	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ICJ78_RS00350	COG1187	pseudouridine synthase activity
ICJ78_RS00355	COG0742	ribosomal rna small subunit methyltransferase
ICJ78_RS00360	COG1674	ftsk spoiiie
ICJ78_RS00365	COG0564	pseudouridine synthase activity
ICJ78_RS00385	COG0590	tRNA wobble adenosine to inosine editing
ICJ78_RS00395	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ICJ78_RS00430	COG0463	Glycosyl transferase, family 2
ICJ78_RS00435	COG0398	Pfam SNARE associated Golgi protein
ICJ78_RS00460	COG0312	modulator of DNA gyrase
ICJ78_RS00465	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ICJ78_RS00470	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ICJ78_RS00495	COG0284	orotidine-5'-phosphate decarboxylase activity
ICJ78_RS00500	COG0135	phosphoribosylanthranilate isomerase activity
ICJ78_RS00525	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ICJ78_RS00540	COG1612	heme a metabolic process
ICJ78_RS00550	COG2814	Major facilitator Superfamily
ICJ78_RS00555	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ICJ78_RS00560	COG1289	transmembrane transporter activity
ICJ78_RS00565	COG0439	Biotin carboxylase
ICJ78_RS00570	COG0511	ligase activity, forming carbon-carbon bonds
ICJ78_RS00575	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ICJ78_RS00580	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ICJ78_RS00585	COG1295	ribonuclease BN
ICJ78_RS00590	COG0019	diaminopimelate decarboxylase activity
ICJ78_RS00600	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ICJ78_RS00605	COG4133	protoheme IX ABC transporter activity
ICJ78_RS00615	COG0583	DNA-binding transcription factor activity
ICJ78_RS00625	COG0542	response to heat
ICJ78_RS00635	COG0779	Required for maturation of 30S ribosomal subunits
ICJ78_RS00650	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ICJ78_RS00650	COG5373	membrane
ICJ78_RS00655	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ICJ78_RS00665	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ICJ78_RS00670	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ICJ78_RS00675	COG1185	polyribonucleotide nucleotidyltransferase activity
ICJ78_RS00685	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ICJ78_RS00690	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ICJ78_RS00695	COG1420	regulation of RNA biosynthetic process
ICJ78_RS00700	COG0667	Aldo Keto reductase
ICJ78_RS00705	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ICJ78_RS00745	COG0778	Nitroreductase
ICJ78_RS00780	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ICJ78_RS00785	COG1396	sequence-specific DNA binding
ICJ78_RS00795	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ICJ78_RS00800	COG1053	succinate dehydrogenase
ICJ78_RS00815	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ICJ78_RS00820	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ICJ78_RS00840	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ICJ78_RS00845	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ICJ78_RS00855	COG0508	dehydrogenase complex catalyzes the overall conversion of
ICJ78_RS00860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ICJ78_RS00870	COG2199	diguanylate cyclase activity
ICJ78_RS00870	COG2202	Pas domain
ICJ78_RS00870	COG2200	EAL domain
ICJ78_RS00890	COG1797	cobyrinic acid a,c-diamide synthase activity
ICJ78_RS00895	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
ICJ78_RS00965	COG0604	alcohol dehydrogenase
ICJ78_RS00975	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ICJ78_RS00985	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ICJ78_RS00990	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ICJ78_RS01005	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ICJ78_RS01030	COG2233	PERMEase
ICJ78_RS01035	COG2814	Major facilitator Superfamily
ICJ78_RS01045	COG1570	exodeoxyribonuclease VII activity
ICJ78_RS01070	COG4221	oxidoreductase activity
ICJ78_RS01075	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ICJ78_RS01090	COG0646	methionine synthase
ICJ78_RS01090	COG1410	methionine synthase
ICJ78_RS01100	COG2274	protein secretion by the type I secretion system
ICJ78_RS01125	COG0438	transferase activity, transferring glycosyl groups
ICJ78_RS01130	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ICJ78_RS01140	COG0488	(ABC) transporter
ICJ78_RS01155	COG2853	Lipoprotein
ICJ78_RS01160	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
ICJ78_RS01185	COG1881	PFAM PEBP family protein
ICJ78_RS01195	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ICJ78_RS01200	COG0343	queuine tRNA-ribosyltransferase activity
ICJ78_RS01205	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ICJ78_RS01215	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ICJ78_RS01220	COG0489	protein tyrosine kinase activity
ICJ78_RS01240	COG0246	Mannitol dehydrogenase
ICJ78_RS01255	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
ICJ78_RS01260	COG2943	transferase activity, transferring hexosyl groups
ICJ78_RS01270	COG2814	Major facilitator Superfamily
ICJ78_RS01280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ICJ78_RS01300	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ICJ78_RS01305	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ICJ78_RS01310	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ICJ78_RS01315	COG0561	phosphatase activity
ICJ78_RS01325	COG0363	glucosamine-6-phosphate deaminase activity
ICJ78_RS01330	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ICJ78_RS01335	COG3265	gluconokinase activity
ICJ78_RS01340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ICJ78_RS01345	COG3001	Fructosamine kinase
ICJ78_RS01355	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ICJ78_RS01360	COG0450	alkyl hydroperoxide reductase
ICJ78_RS01365	COG0583	DNA-binding transcription factor activity
ICJ78_RS01370	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ICJ78_RS01395	COG0483	inositol monophosphate 1-phosphatase activity
ICJ78_RS01400	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ICJ78_RS01405	COG1509	lysine 2,3-aminomutase activity
ICJ78_RS01410	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ICJ78_RS01415	COG0352	thiamine-phosphate diphosphorylase activity
ICJ78_RS01440	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ICJ78_RS01445	COG1692	metallophosphoesterase
ICJ78_RS01450	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ICJ78_RS01460	COG2267	carboxylic ester hydrolase activity
ICJ78_RS01465	COG3321	synthase
ICJ78_RS01465	COG1028	Short-chain dehydrogenase reductase Sdr
ICJ78_RS01465	COG0604	alcohol dehydrogenase
ICJ78_RS01500	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ICJ78_RS01505	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ICJ78_RS01535	COG0129	dihydroxy-acid dehydratase activity
ICJ78_RS01560	COG4221	oxidoreductase activity
ICJ78_RS01585	COG0481	GTPase activity
ICJ78_RS01610	COG0513	Belongs to the DEAD box helicase family
ICJ78_RS01630	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ICJ78_RS01665	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ICJ78_RS01670	COG5487	UPF0391 membrane protein
ICJ78_RS01685	COG0776	regulation of translation
ICJ78_RS01695	COG1139	Iron-sulfur cluster binding protein
ICJ78_RS01700	COG0247	lactate metabolic process
ICJ78_RS01730	COG2308	Evidence 4 Homologs of previously reported genes of
ICJ78_RS01770	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ICJ78_RS01780	COG1496	oxidoreductase activity
ICJ78_RS01790	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ICJ78_RS01795	COG0406	alpha-ribazole phosphatase activity
ICJ78_RS01800	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ICJ78_RS01805	COG0193	aminoacyl-tRNA hydrolase activity
ICJ78_RS01810	COG0012	GTP binding
ICJ78_RS01815	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ICJ78_RS01820	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ICJ78_RS01825	COG0799	negative regulation of ribosome biogenesis
ICJ78_RS01830	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ICJ78_RS01840	COG0251	oxidation-reduction process
ICJ78_RS01860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ICJ78_RS01885	COG1192	Involved in chromosome partitioning
ICJ78_RS01980	COG4691	Plasmid stability protein
ICJ78_RS01985	COG1487	ribonuclease activity
ICJ78_RS02100	COG0071	Belongs to the small heat shock protein (HSP20) family
ICJ78_RS02120	COG3077	Addiction module antitoxin, RelB DinJ family
ICJ78_RS02125	COG2026	Addiction module toxin, RelE StbE family
ICJ78_RS02135	COG2199	diguanylate cyclase activity
ICJ78_RS02135	COG2200	EAL domain
ICJ78_RS02135	COG2202	Pas domain
ICJ78_RS02155	COG3210	domain, Protein
ICJ78_RS02330	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
ICJ78_RS02335	COG0517	IMP dehydrogenase activity
ICJ78_RS02345	COG4584	PFAM Integrase catalytic
ICJ78_RS02350	COG1484	DNA-dependent DNA replication
ICJ78_RS02485	COG1215	transferase activity, transferring glycosyl groups
ICJ78_RS02500	COG0662	Cupin 2, conserved barrel domain protein
ICJ78_RS02500	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ICJ78_RS02505	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ICJ78_RS02535	COG0495	leucyl-tRNA aminoacylation
ICJ78_RS02545	COG1472	Belongs to the glycosyl hydrolase 3 family
ICJ78_RS02565	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ICJ78_RS02570	COG3158	transport of potassium into the cell
ICJ78_RS02575	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ICJ78_RS02580	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ICJ78_RS02580	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ICJ78_RS02585	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ICJ78_RS02595	COG0438	transferase activity, transferring glycosyl groups
ICJ78_RS02605	COG2309	aminopeptidase activity
ICJ78_RS02610	COG2146	nitrite reductase [NAD(P)H] activity
ICJ78_RS02620	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ICJ78_RS02625	COG2945	thiolester hydrolase activity
ICJ78_RS02645	COG0482	sulfurtransferase activity
ICJ78_RS02660	COG0523	cobalamin synthesis protein
ICJ78_RS02670	COG0438	transferase activity, transferring glycosyl groups
ICJ78_RS02680	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ICJ78_RS02685	COG1230	cation diffusion facilitator family transporter
ICJ78_RS02690	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
ICJ78_RS02700	COG4974	Belongs to the 'phage' integrase family
ICJ78_RS02720	COG0347	Belongs to the P(II) protein family
ICJ78_RS02725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ICJ78_RS02735	COG0493	'glutamate synthase
ICJ78_RS02735	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ICJ78_RS02750	COG1530	ribonuclease E activity
ICJ78_RS02755	COG0860	N-Acetylmuramoyl-L-alanine amidase
ICJ78_RS02760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ICJ78_RS02785	COG0768	penicillin binding
ICJ78_RS02790	COG0772	Belongs to the SEDS family
ICJ78_RS02805	COG0752	glycyl-tRNA synthetase alpha subunit
ICJ78_RS02810	COG3416	Protein conserved in bacteria
ICJ78_RS02815	COG3145	DNA-N1-methyladenine dioxygenase activity
ICJ78_RS02820	COG0800	Aldolase
ICJ78_RS02825	COG0129	dihydroxy-acid dehydratase activity
ICJ78_RS02840	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ICJ78_RS02845	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ICJ78_RS02850	COG0629	single-stranded DNA binding
ICJ78_RS02860	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ICJ78_RS02875	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ICJ78_RS02880	COG0509	glycine decarboxylation via glycine cleavage system
ICJ78_RS02885	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ICJ78_RS02885	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ICJ78_RS02895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ICJ78_RS02900	COG1120	ATPase activity
ICJ78_RS02920	COG0346	lactoylglutathione lyase activity
ICJ78_RS02925	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ICJ78_RS02930	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ICJ78_RS02935	COG0552	protein localization to endoplasmic reticulum
ICJ78_RS02945	COG0126	phosphoglycerate kinase activity
ICJ78_RS02965	COG0156	8-amino-7-oxononanoate synthase activity
ICJ78_RS02975	COG0405	Gamma-glutamyltransferase
ICJ78_RS02995	COG1072	(Pantothenic acid kinase))
ICJ78_RS03000	COG1012	belongs to the aldehyde dehydrogenase family
ICJ78_RS03010	COG1802	Transcriptional regulator
ICJ78_RS03015	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ICJ78_RS03025	COG0850	regulation of cytokinetic process
ICJ78_RS03035	COG2081	HI0933 family
ICJ78_RS03040	COG1696	Membrane protein involved in D-alanine export
ICJ78_RS03045	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ICJ78_RS03050	COG0564	pseudouridine synthase activity
ICJ78_RS03065	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ICJ78_RS03065	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ICJ78_RS03075	COG3852	Histidine kinase
ICJ78_RS03090	COG2204	response regulator
ICJ78_RS03095	COG1923	regulation of RNA biosynthetic process
ICJ78_RS03100	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ICJ78_RS03105	COG0483	inositol monophosphate 1-phosphatase activity
ICJ78_RS03110	COG3956	TIGRFAM MazG family protein
ICJ78_RS03130	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ICJ78_RS03135	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ICJ78_RS03145	COG0564	pseudouridine synthase activity
ICJ78_RS03195	COG3161	chorismate lyase activity
ICJ78_RS03205	COG1051	belongs to the nudix hydrolase family
ICJ78_RS03210	COG0326	Molecular chaperone. Has ATPase activity
ICJ78_RS03215	COG2226	methyltransferase
ICJ78_RS03220	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ICJ78_RS03225	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ICJ78_RS03235	COG0708	Exodeoxyribonuclease III
ICJ78_RS03245	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ICJ78_RS03250	COG0018	arginyl-trna synthetase
ICJ78_RS03260	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ICJ78_RS03270	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ICJ78_RS03275	COG0805	protein transport
ICJ78_RS03280	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ICJ78_RS03305	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ICJ78_RS03320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ICJ78_RS03330	COG0215	cysteine-tRNA ligase activity
ICJ78_RS03335	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ICJ78_RS03340	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ICJ78_RS03370	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ICJ78_RS03380	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ICJ78_RS03380	COG2885	chlorophyll binding
ICJ78_RS03385	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ICJ78_RS03385	COG2885	chlorophyll binding
ICJ78_RS03390	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ICJ78_RS03390	COG2885	chlorophyll binding
ICJ78_RS03395	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ICJ78_RS03405	COG4974	Belongs to the 'phage' integrase family
ICJ78_RS03410	COG0825	malonyl-CoA metabolic process
ICJ78_RS03415	COG1546	Belongs to the CinA family
ICJ78_RS03415	COG1058	Belongs to the CinA family
ICJ78_RS03440	COG1862	Preprotein translocase
ICJ78_RS03445	COG2814	Major facilitator Superfamily
ICJ78_RS03490	COG1758	RNA polymerase activity
ICJ78_RS03500	COG0736	holo-[acyl-carrier-protein] synthase activity
ICJ78_RS03505	COG0681	Belongs to the peptidase S26 family
ICJ78_RS03510	COG0571	ribonuclease III activity
ICJ78_RS03515	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ICJ78_RS03520	COG0528	UMP kinase activity
ICJ78_RS03525	COG0233	cytoplasmic translational termination
ICJ78_RS03530	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ICJ78_RS03540	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ICJ78_RS03545	COG0750	zinc metalloprotease
ICJ78_RS03550	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ICJ78_RS03560	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ICJ78_RS03565	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ICJ78_RS03570	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ICJ78_RS03575	COG3494	Protein of unknown function (DUF1009)
ICJ78_RS03580	COG0346	lactoylglutathione lyase activity
ICJ78_RS03590	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ICJ78_RS03595	COG0594	ribonuclease P activity
ICJ78_RS03600	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ICJ78_RS03605	COG0706	membrane insertase activity
ICJ78_RS03610	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ICJ78_RS03615	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ICJ78_RS03620	COG2171	N-acyltransferase activity
ICJ78_RS03625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ICJ78_RS03635	COG0101	tRNA pseudouridine synthase activity
ICJ78_RS03640	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ICJ78_RS03645	COG0242	peptide deformylase activity
ICJ78_RS03660	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ICJ78_RS03665	COG1137	ATPase activity
ICJ78_RS03680	COG0517	IMP dehydrogenase activity
ICJ78_RS03680	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ICJ78_RS03715	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ICJ78_RS03720	COG0556	nucleotide-excision repair
ICJ78_RS03735	COG0189	ligase activity
ICJ78_RS03745	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ICJ78_RS03750	COG0109	protoheme IX farnesyltransferase activity
ICJ78_RS03765	COG0312	modulator of DNA gyrase
ICJ78_RS03770	COG0612	Peptidase, M16
ICJ78_RS03785	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ICJ78_RS03795	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ICJ78_RS03800	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ICJ78_RS03805	COG0728	peptidoglycan biosynthetic process
ICJ78_RS03810	COG0386	Belongs to the glutathione peroxidase family
ICJ78_RS03815	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ICJ78_RS03820	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ICJ78_RS03825	COG0181	hydroxymethylbilane synthase activity
ICJ78_RS03835	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ICJ78_RS03855	COG1858	cytochrome C peroxidase
ICJ78_RS03870	COG0408	coproporphyrinogen oxidase activity
ICJ78_RS03875	COG2857	Cytochrome c1
ICJ78_RS03875	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ICJ78_RS03880	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ICJ78_RS03885	COG0412	Dienelactone hydrolase
ICJ78_RS03895	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ICJ78_RS03900	COG0459	protein refolding
ICJ78_RS03905	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ICJ78_RS03910	COG1278	Cold shock
ICJ78_RS03915	COG1199	ATP-dependent helicase activity
ICJ78_RS03930	COG2095	MarC family integral membrane protein
ICJ78_RS03940	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ICJ78_RS03955	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ICJ78_RS03960	COG0670	Belongs to the BI1 family
ICJ78_RS03980	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ICJ78_RS04000	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ICJ78_RS04015	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ICJ78_RS04020	COG1086	Polysaccharide biosynthesis protein
ICJ78_RS04035	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ICJ78_RS04050	COG2814	Major facilitator Superfamily
ICJ78_RS04055	COG0488	(ABC) transporter
ICJ78_RS04060	COG0105	UTP biosynthetic process
ICJ78_RS04065	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ICJ78_RS04070	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ICJ78_RS04080	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ICJ78_RS04100	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ICJ78_RS04110	COG0583	DNA-binding transcription factor activity
ICJ78_RS04115	COG2072	flavoprotein involved in K transport
ICJ78_RS04140	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ICJ78_RS04160	COG0473	3-isopropylmalate dehydrogenase activity
ICJ78_RS04165	COG0006	proline dipeptidase activity
ICJ78_RS04175	COG2264	protein methyltransferase activity
ICJ78_RS04180	COG0210	DNA helicase
ICJ78_RS04185	COG2003	Belongs to the UPF0758 family
ICJ78_RS04190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ICJ78_RS04195	COG2003	Belongs to the UPF0758 family
ICJ78_RS04200	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ICJ78_RS04225	COG0071	Belongs to the small heat shock protein (HSP20) family
ICJ78_RS04230	COG0254	rRNA binding
ICJ78_RS04235	COG1970	mechanosensitive ion channel activity
ICJ78_RS04250	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ICJ78_RS04260	COG0488	(ABC) transporter
ICJ78_RS04265	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
ICJ78_RS04270	COG0784	Response regulator, receiver
ICJ78_RS04295	COG4988	ABC transporter
ICJ78_RS04300	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ICJ78_RS04315	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ICJ78_RS04320	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ICJ78_RS04325	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ICJ78_RS04340	COG0837	glucose binding
ICJ78_RS04430	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ICJ78_RS04455	COG0789	Transcriptional regulator
ICJ78_RS04460	COG2072	flavoprotein involved in K transport
ICJ78_RS04465	COG0431	NADPH-dependent FMN reductase
ICJ78_RS04490	COG3038	cytochrome b561
ICJ78_RS04540	COG0583	DNA-binding transcription factor activity
ICJ78_RS04580	COG5489	Protein of unknown function (DUF736)
ICJ78_RS04630	COG0741	lytic transglycosylase activity
ICJ78_RS04660	COG4962	Type ii secretion system protein e
ICJ78_RS04665	COG3838	Conjugal transfer protein Trbc
ICJ78_RS04675	COG3451	type IV secretory pathway VirB4
ICJ78_RS04710	COG0583	DNA-binding transcription factor activity
ICJ78_RS04720	COG2372	response to copper ion
ICJ78_RS04730	COG1858	cytochrome C peroxidase
ICJ78_RS04755	COG4771	TonB-dependent receptor
ICJ78_RS04765	COG4974	Belongs to the 'phage' integrase family
ICJ78_RS04810	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ICJ78_RS04820	COG3284	Transcriptional regulator
ICJ78_RS04825	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ICJ78_RS04830	COG0022	dehydrogenase e1 component
ICJ78_RS04840	COG1070	Carbohydrate kinase
ICJ78_RS04850	COG2814	Major facilitator Superfamily
ICJ78_RS04875	COG1091	dTDP-4-dehydrorhamnose reductase activity
ICJ78_RS04885	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ICJ78_RS04900	COG0438	transferase activity, transferring glycosyl groups
ICJ78_RS04905	COG1216	Glycosyl transferase, family 2
ICJ78_RS04910	COG0438	transferase activity, transferring glycosyl groups
ICJ78_RS04915	COG1215	transferase activity, transferring glycosyl groups
ICJ78_RS04920	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ICJ78_RS04940	COG0489	protein tyrosine kinase activity
ICJ78_RS04940	COG3206	protein involved in exopolysaccharide biosynthesis
ICJ78_RS04960	COG1596	polysaccharide export
ICJ78_RS04965	COG2755	lipolytic protein G-D-S-L family
ICJ78_RS04965	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ICJ78_RS05005	COG5564	TIM-barrel signal transduction protein
ICJ78_RS05025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ICJ78_RS05035	COG3525	Glycosyl hydrolase, family 20, catalytic domain
ICJ78_RS05040	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ICJ78_RS05055	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ICJ78_RS05065	COG0525	valine-tRNA ligase activity
ICJ78_RS05070	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ICJ78_RS05075	COG1116	anion transmembrane transporter activity
ICJ78_RS05080	COG4176	ABC-type proline glycine betaine transport system permease component
ICJ78_RS05085	COG0756	dUTP diphosphatase activity
ICJ78_RS05090	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ICJ78_RS05095	COG2226	methyltransferase
ICJ78_RS05100	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ICJ78_RS05105	COG0268	Binds directly to 16S ribosomal RNA
ICJ78_RS05110	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ICJ78_RS05120	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ICJ78_RS05130	COG0546	phosphoglycolate phosphatase activity
ICJ78_RS05135	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ICJ78_RS05140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ICJ78_RS05155	COG2022	thiamine diphosphate biosynthetic process
ICJ78_RS05180	COG0019	diaminopimelate decarboxylase activity
ICJ78_RS05185	COG0295	cytidine deaminase activity
ICJ78_RS05195	COG0165	Argininosuccinate lyase
ICJ78_RS05205	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ICJ78_RS05210	COG0237	dephospho-CoA kinase activity
ICJ78_RS05215	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ICJ78_RS05245	COG0659	secondary active sulfate transmembrane transporter activity
ICJ78_RS05255	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ICJ78_RS05260	COG0602	queuosine metabolic process
ICJ78_RS05265	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ICJ78_RS05275	COG0045	succinate-CoA ligase (ADP-forming) activity
ICJ78_RS05295	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ICJ78_RS05315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ICJ78_RS05320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ICJ78_RS05325	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ICJ78_RS05335	COG0483	inositol monophosphate 1-phosphatase activity
ICJ78_RS05380	COG0156	8-amino-7-oxononanoate synthase activity
ICJ78_RS05390	COG0318	PFAM AMP-dependent synthetase and ligase
ICJ78_RS05455	COG1476	TRANSCRIPTIONal
ICJ78_RS05570	COG1959	2 iron, 2 sulfur cluster binding
ICJ78_RS05575	COG3328	transposase activity
ICJ78_RS05650	COG0745	RESPONSE REGULATOR receiver
ICJ78_RS05665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ICJ78_RS05725	COG0673	inositol 2-dehydrogenase activity
ICJ78_RS05740	COG1609	Transcriptional regulator
ICJ78_RS05760	COG4716	Myosin-crossreactive antigen
ICJ78_RS05770	COG0642	Histidine kinase
ICJ78_RS05780	COG0277	FAD linked oxidase domain protein
ICJ78_RS05785	COG0247	lactate metabolic process
ICJ78_RS05800	COG2814	Major facilitator Superfamily
ICJ78_RS05805	COG3511	phospholipase C
ICJ78_RS05825	COG1953	Uracil, thiamine, allantoin
ICJ78_RS05830	COG1028	Short-chain dehydrogenase reductase Sdr
ICJ78_RS05835	COG3842	ATPase activity
ICJ78_RS05845	COG1175	transmembrane transport
ICJ78_RS05855	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ICJ78_RS05865	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ICJ78_RS05895	COG0697	spore germination
ICJ78_RS05905	COG2837	iron assimilation
ICJ78_RS05910	COG2271	Major facilitator Superfamily
ICJ78_RS05915	COG0697	spore germination
ICJ78_RS05920	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ICJ78_RS05925	COG1984	allophanate hydrolase subunit 2
ICJ78_RS05935	COG4221	oxidoreductase activity
ICJ78_RS05955	COG0436	Aminotransferase
ICJ78_RS05960	COG1027	Aspartate ammonia-lyase
ICJ78_RS05975	COG3588	fructose-bisphosphate aldolase
ICJ78_RS05990	COG1113	amino acid transport
ICJ78_RS05995	COG0596	Alpha beta hydrolase
ICJ78_RS06000	COG0500	methyltransferase
ICJ78_RS06015	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ICJ78_RS06050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ICJ78_RS06100	COG3459	Glycosyltransferase 36 associated
ICJ78_RS06110	COG0025	NhaP-type Na H and K H
ICJ78_RS06120	COG1028	Short-chain dehydrogenase reductase Sdr
ICJ78_RS06130	COG2771	luxR family
ICJ78_RS06135	COG1054	Belongs to the UPF0176 family
ICJ78_RS06140	COG1393	Belongs to the ArsC family
ICJ78_RS06145	COG1597	lipid kinase activity
ICJ78_RS06160	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ICJ78_RS06180	COG0420	3'-5' exonuclease activity
ICJ78_RS06185	COG1012	belongs to the aldehyde dehydrogenase family
ICJ78_RS06190	COG0583	DNA-binding transcription factor activity
ICJ78_RS06195	COG1278	Cold shock
ICJ78_RS06200	COG3128	pkhd-type hydroxylase
ICJ78_RS06205	COG4774	siderophore transport
ICJ78_RS06230	COG0281	malic enzyme
ICJ78_RS06235	COG1289	transmembrane transporter activity
ICJ78_RS06245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ICJ78_RS06250	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ICJ78_RS06255	COG1522	sequence-specific DNA binding
ICJ78_RS06270	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ICJ78_RS06275	COG1494	fructose-1,6-bisphosphatase
ICJ78_RS06280	COG0191	fructose-bisphosphate aldolase activity
ICJ78_RS06290	COG1028	Short-chain dehydrogenase reductase Sdr
ICJ78_RS06295	COG1252	NADH dehydrogenase
ICJ78_RS06305	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ICJ78_RS06310	COG4208	sulfate ABC transporter
ICJ78_RS06320	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ICJ78_RS06330	COG1309	transcriptional regulator
ICJ78_RS06345	COG0679	Auxin Efflux Carrier
ICJ78_RS06360	COG0306	phosphate transporter
ICJ78_RS06375	COG0573	inorganic phosphate transmembrane transporter activity
ICJ78_RS06380	COG0581	inorganic phosphate transmembrane transporter activity
ICJ78_RS06385	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ICJ78_RS06395	COG0277	FAD linked oxidase domain protein
ICJ78_RS06425	COG0753	catalase activity
ICJ78_RS06440	COG2169	Transcriptional regulator
ICJ78_RS06440	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ICJ78_RS06445	COG1584	GPR1 FUN34 yaaH family protein
ICJ78_RS06450	COG1231	oxidoreductase activity
ICJ78_RS06465	COG2010	Cytochrome c
ICJ78_RS06480	COG1289	transmembrane transporter activity
ICJ78_RS06515	COG0730	response to heat
ICJ78_RS06520	COG1858	cytochrome C peroxidase
ICJ78_RS06530	COG3118	belongs to the thioredoxin family
ICJ78_RS06560	COG3104	oligopeptide transport
ICJ78_RS06565	COG2134	cdp-diacylglycerol pyrophosphatase
ICJ78_RS06620	COG0297	glycogen (starch) synthase activity
ICJ78_RS06625	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ICJ78_RS06630	COG1523	belongs to the glycosyl hydrolase 13 family
ICJ78_RS06635	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ICJ78_RS06640	COG1640	4-alpha-glucanotransferase
ICJ78_RS06665	COG0668	transmembrane transport
ICJ78_RS06675	COG1914	H( )-stimulated, divalent metal cation uptake system
ICJ78_RS06685	COG1253	flavin adenine dinucleotide binding
ICJ78_RS06695	COG0583	DNA-binding transcription factor activity
ICJ78_RS06705	COG3634	alkyl hydroperoxide reductase activity
ICJ78_RS06710	COG1012	belongs to the aldehyde dehydrogenase family
ICJ78_RS06720	COG2353	YceI-like domain
ICJ78_RS06750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ICJ78_RS06760	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ICJ78_RS06770	COG4608	Belongs to the ABC transporter superfamily
ICJ78_RS06785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ICJ78_RS06790	COG1621	beta-fructofuranosidase activity
ICJ78_RS06810	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ICJ78_RS06815	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ICJ78_RS06820	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ICJ78_RS06840	COG1028	Short-chain dehydrogenase reductase Sdr
ICJ78_RS06865	COG1741	Belongs to the pirin family
ICJ78_RS06870	COG0583	DNA-binding transcription factor activity
ICJ78_RS06875	COG0655	NAD(P)H dehydrogenase (quinone) activity
ICJ78_RS06880	COG3128	pkhd-type hydroxylase
ICJ78_RS06895	COG4774	siderophore transport
ICJ78_RS06900	COG1683	Conserved Protein
ICJ78_RS06905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ICJ78_RS06910	COG2084	Dehydrogenase
ICJ78_RS06915	COG1064	alcohol dehydrogenase
ICJ78_RS06920	COG0667	Aldo Keto reductase
ICJ78_RS06925	COG2207	Transcriptional regulator
ICJ78_RS06965	COG0366	Alpha amylase catalytic
ICJ78_RS06970	COG0366	Alpha amylase catalytic
ICJ78_RS06975	COG0673	inositol 2-dehydrogenase activity
ICJ78_RS07000	COG0366	Alpha amylase catalytic
ICJ78_RS07025	COG2814	Major facilitator Superfamily
ICJ78_RS07040	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ICJ78_RS07045	COG2313	pseudouridylate synthase activity
ICJ78_RS07050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ICJ78_RS07050	COG1522	sequence-specific DNA binding
ICJ78_RS07055	COG1309	transcriptional regulator
ICJ78_RS07060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ICJ78_RS07065	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ICJ78_RS07070	COG1942	4-Oxalocrotonate Tautomerase
ICJ78_RS07075	COG0493	'glutamate synthase
ICJ78_RS07095	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ICJ78_RS07100	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ICJ78_RS07105	COG1309	transcriptional regulator
ICJ78_RS07110	COG1657	PFAM Prenyltransferase squalene oxidase
ICJ78_RS07135	COG1695	Transcriptional regulator
ICJ78_RS07150	COG0477	Major facilitator Superfamily
ICJ78_RS07180	COG1028	Short-chain dehydrogenase reductase Sdr
ICJ78_RS07190	COG3962	Belongs to the TPP enzyme family
ICJ78_RS07215	COG0477	Major facilitator Superfamily
ICJ78_RS07215	COG2814	Major facilitator Superfamily
ICJ78_RS07220	COG1942	4-Oxalocrotonate Tautomerase
ICJ78_RS07225	COG2814	Major facilitator Superfamily
ICJ78_RS07230	COG0673	inositol 2-dehydrogenase activity
ICJ78_RS07235	COG0583	DNA-binding transcription factor activity
ICJ78_RS07245	COG1032	radical SAM domain protein
ICJ78_RS07270	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ICJ78_RS07360	COG1744	ABC transporter substrate-binding protein PnrA-like
ICJ78_RS07380	COG4251	negative regulation of phosphorylation
ICJ78_RS07385	COG2202	Pas domain
ICJ78_RS07385	COG2200	EAL domain
ICJ78_RS07385	COG2199	diguanylate cyclase activity
ICJ78_RS07405	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ICJ78_RS07410	COG2202	Pas domain
ICJ78_RS07410	COG2200	EAL domain
ICJ78_RS07410	COG2199	diguanylate cyclase activity
ICJ78_RS07420	COG1959	2 iron, 2 sulfur cluster binding
ICJ78_RS07425	COG1959	2 iron, 2 sulfur cluster binding
ICJ78_RS07430	COG4993	Dehydrogenase
ICJ78_RS07435	COG4993	Dehydrogenase
ICJ78_RS07440	COG2818	Glycosylase
ICJ78_RS07450	COG1401	restriction endodeoxyribonuclease activity
ICJ78_RS07470	COG3042	response to heat
ICJ78_RS07490	COG1902	pentaerythritol trinitrate reductase activity
ICJ78_RS07505	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ICJ78_RS07510	COG2855	membrane
ICJ78_RS07515	COG0583	DNA-binding transcription factor activity
ICJ78_RS07725	COG1285	pathogenesis
ICJ78_RS07795	COG1028	Short-chain dehydrogenase reductase Sdr
ICJ78_RS07835	COG2814	Major facilitator Superfamily
ICJ78_RS07860	COG3128	pkhd-type hydroxylase
ICJ78_RS07870	COG0402	S-adenosylhomocysteine deaminase activity
ICJ78_RS07895	COG4638	Rieske (2fe-2S)
ICJ78_RS07910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ICJ78_RS07915	COG1116	anion transmembrane transporter activity
ICJ78_RS07920	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ICJ78_RS07935	COG1012	belongs to the aldehyde dehydrogenase family
ICJ78_RS07945	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ICJ78_RS07960	COG0662	Cupin 2, conserved barrel domain protein
ICJ78_RS07970	COG0277	FAD linked oxidase domain protein
ICJ78_RS07970	COG0247	lactate metabolic process
ICJ78_RS07980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ICJ78_RS07985	COG1116	anion transmembrane transporter activity
ICJ78_RS07985	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ICJ78_RS07995	COG0402	S-adenosylhomocysteine deaminase activity
ICJ78_RS08000	COG0402	S-adenosylhomocysteine deaminase activity
ICJ78_RS08015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ICJ78_RS08030	COG3511	phospholipase C
ICJ78_RS08040	COG2252	PERMEase
ICJ78_RS08045	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ICJ78_RS08050	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ICJ78_RS08060	COG2249	NAD(P)H dehydrogenase (quinone) activity
ICJ78_RS08065	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ICJ78_RS08115	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ICJ78_RS08120	COG0583	DNA-binding transcription factor activity
ICJ78_RS08150	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ICJ78_RS08155	COG1957	nucleoside hydrolase
ICJ78_RS08170	COG3842	ATPase activity
ICJ78_RS08175	COG1176	ABC-type spermidine putrescine transport system, permease component I
ICJ78_RS08180	COG1177	transmembrane transport
ICJ78_RS08210	COG4774	siderophore transport
ICJ78_RS08230	COG0848	biopolymer transport protein
ICJ78_RS08250	COG1695	Transcriptional regulator
ICJ78_RS08285	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ICJ78_RS08290	COG0154	amidase activity
ICJ78_RS08295	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ICJ78_RS08300	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ICJ78_RS08315	COG2824	Alkylphosphonate utilization operon protein PhnA
ICJ78_RS08335	COG1671	Belongs to the UPF0178 family
ICJ78_RS08370	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ICJ78_RS08375	COG0628	permease
ICJ78_RS08380	COG0732	type I restriction modification DNA specificity domain
ICJ78_RS08385	COG0534	Mate efflux family protein
ICJ78_RS08405	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ICJ78_RS08410	COG0483	inositol monophosphate 1-phosphatase activity
ICJ78_RS08415	COG3474	cytochrome
ICJ78_RS08420	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ICJ78_RS08425	COG0077	Prephenate dehydratase
ICJ78_RS08430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ICJ78_RS08435	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ICJ78_RS08440	COG1278	Cold shock
ICJ78_RS08445	COG1309	transcriptional regulator
ICJ78_RS08455	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ICJ78_RS08460	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ICJ78_RS08480	COG0076	glutamate decarboxylase activity
ICJ78_RS08510	COG0321	lipoyl(octanoyl) transferase activity
ICJ78_RS08535	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ICJ78_RS08545	COG1040	competence protein
ICJ78_RS08565	COG2706	6-phosphogluconolactonase activity
ICJ78_RS08570	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ICJ78_RS08575	COG0527	aspartate kinase activity
ICJ78_RS08580	COG2070	2-Nitropropane dioxygenase
ICJ78_RS08590	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ICJ78_RS08595	COG0124	histidyl-tRNA synthetase
ICJ78_RS08600	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ICJ78_RS08610	COG2890	protein-(glutamine-N5) methyltransferase activity
ICJ78_RS08630	COG0156	8-amino-7-oxononanoate synthase activity
ICJ78_RS08640	COG4106	trans-aconitate 2-methyltransferase activity
ICJ78_RS08640	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ICJ78_RS08645	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ICJ78_RS08650	COG0303	'Molybdopterin
ICJ78_RS08655	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ICJ78_RS08665	COG0148	phosphopyruvate hydratase activity
ICJ78_RS08685	COG2010	Cytochrome c
ICJ78_RS08685	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ICJ78_RS08690	COG4993	Dehydrogenase
ICJ78_RS08700	COG0438	transferase activity, transferring glycosyl groups
ICJ78_RS08705	COG0305	Participates in initiation and elongation during chromosome replication
ICJ78_RS08710	COG0606	chelatase, subunit chli
ICJ78_RS08735	COG0513	Belongs to the DEAD box helicase family
ICJ78_RS08745	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ICJ78_RS08750	COG0531	amino acid
ICJ78_RS08755	COG0113	porphobilinogen synthase activity
ICJ78_RS08760	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
ICJ78_RS08765	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ICJ78_RS08770	COG1381	Involved in DNA repair and RecF pathway recombination
ICJ78_RS08775	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ICJ78_RS08780	COG0052	Belongs to the universal ribosomal protein uS2 family
ICJ78_RS08785	COG1764	response to oxidative stress
ICJ78_RS08790	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ICJ78_RS08795	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ICJ78_RS08800	COG0259	pyridoxamine-phosphate oxidase activity
ICJ78_RS08810	COG0175	sulfate reduction
ICJ78_RS08830	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ICJ78_RS08840	COG1519	Transferase
ICJ78_RS08845	COG1663	tetraacyldisaccharide 4'-kinase activity
ICJ78_RS08855	COG4372	Transposase
ICJ78_RS08865	COG2963	transposase activity
ICJ78_RS08880	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ICJ78_RS08920	COG1335	isochorismatase
ICJ78_RS08925	COG1160	GTP binding
ICJ78_RS08950	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ICJ78_RS08960	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ICJ78_RS08965	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ICJ78_RS08970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ICJ78_RS08970	COG0072	phenylalanine-tRNA ligase activity
ICJ78_RS08975	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ICJ78_RS08980	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ICJ78_RS08985	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ICJ78_RS08990	COG1028	Short-chain dehydrogenase reductase Sdr
ICJ78_RS09005	COG0248	Ppx GppA phosphatase
ICJ78_RS09010	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ICJ78_RS09015	COG1940	carbohydrate kinase activity
ICJ78_RS09020	COG0425	Belongs to the sulfur carrier protein TusA family
ICJ78_RS09025	COG1722	exodeoxyribonuclease VII activity
ICJ78_RS09035	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ICJ78_RS09040	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ICJ78_RS09045	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ICJ78_RS09050	COG0137	argininosuccinate synthase activity
ICJ78_RS09065	COG0180	Tryptophanyl-tRNA synthetase
ICJ78_RS09070	COG0432	Pfam Uncharacterised protein family UPF0047
ICJ78_RS09075	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
ICJ78_RS09080	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ICJ78_RS09085	COG3781	membrane
ICJ78_RS09095	COG2814	Major facilitator Superfamily
ICJ78_RS09105	COG0729	surface antigen
ICJ78_RS09110	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ICJ78_RS09115	COG1702	phosphate starvation-inducible protein PhoH
ICJ78_RS09120	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ICJ78_RS09135	COG1196	nuclear chromosome segregation
ICJ78_RS09150	COG1605	Chorismate mutase
ICJ78_RS09150	COG0287	Prephenate dehydrogenase
ICJ78_RS09170	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ICJ78_RS09175	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ICJ78_RS09180	COG0142	geranyltranstransferase activity
ICJ78_RS09190	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ICJ78_RS09195	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ICJ78_RS09195	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ICJ78_RS09200	COG0314	molybdopterin synthase activity
ICJ78_RS09205	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ICJ78_RS09220	COG0322	excinuclease ABC activity
ICJ78_RS09230	COG0745	RESPONSE REGULATOR receiver
ICJ78_RS09255	COG0321	lipoyl(octanoyl) transferase activity
ICJ78_RS09255	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ICJ78_RS09260	COG0084	hydrolase, TatD family'
ICJ78_RS09275	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ICJ78_RS09280	COG1686	Belongs to the peptidase S11 family
ICJ78_RS09285	COG2951	lytic endotransglycosylase activity
ICJ78_RS09290	COG0586	Pfam SNARE associated Golgi protein
ICJ78_RS09305	COG1968	undecaprenyl-diphosphatase activity
ICJ78_RS09335	COG3676	manually curated
ICJ78_RS09380	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ICJ78_RS09405	COG1272	protein, Hemolysin III
ICJ78_RS09410	COG2814	Major facilitator Superfamily
ICJ78_RS09440	COG0626	cystathionine gamma-synthase activity
ICJ78_RS09450	COG0628	permease
ICJ78_RS09460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ICJ78_RS09465	COG0792	nuclease activity
ICJ78_RS09475	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ICJ78_RS09480	COG0271	Belongs to the BolA IbaG family
ICJ78_RS09485	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ICJ78_RS09490	COG0047	phosphoribosylformylglycinamidine synthase activity
ICJ78_RS09500	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ICJ78_RS09505	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ICJ78_RS09515	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ICJ78_RS09520	COG0861	Integral membrane protein TerC family
ICJ78_RS09530	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ICJ78_RS09535	COG1058	Belongs to the CinA family
ICJ78_RS09535	COG1546	Belongs to the CinA family
ICJ78_RS09550	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ICJ78_RS09560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ICJ78_RS09565	COG0508	dehydrogenase complex catalyzes the overall conversion of
ICJ78_RS09570	COG0508	dehydrogenase complex catalyzes the overall conversion of
ICJ78_RS09570	COG0022	dehydrogenase e1 component
ICJ78_RS09575	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ICJ78_RS09580	COG0315	cyclic pyranopterin monophosphate synthase activity
ICJ78_RS09585	COG0134	indole-3-glycerol-phosphate synthase activity
ICJ78_RS09590	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ICJ78_RS09600	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ICJ78_RS09615	COG0149	triose-phosphate isomerase activity
ICJ78_RS09620	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ICJ78_RS09625	COG0504	CTP synthase activity
ICJ78_RS09630	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ICJ78_RS09650	COG5001	Diguanylate cyclase
ICJ78_RS09650	COG3300	MHYT domain
ICJ78_RS09685	COG1012	belongs to the aldehyde dehydrogenase family
ICJ78_RS09705	COG0848	biopolymer transport protein
ICJ78_RS09730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ICJ78_RS09740	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ICJ78_RS09745	COG1301	dicarboxylic acid transport
ICJ78_RS09750	COG2211	Major facilitator Superfamily
ICJ78_RS09780	COG1335	isochorismatase
ICJ78_RS09790	COG0583	DNA-binding transcription factor activity
ICJ78_RS09820	COG0519	Catalyzes the synthesis of GMP from XMP
ICJ78_RS09820	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ICJ78_RS09845	COG1522	sequence-specific DNA binding
ICJ78_RS09850	COG0492	ferredoxin-NADP+ reductase activity
ICJ78_RS09855	COG0583	DNA-binding transcription factor activity
ICJ78_RS09860	COG0776	regulation of translation
ICJ78_RS09875	COG0640	Transcriptional regulator
ICJ78_RS09885	COG1573	uracil-dna glycosylase
ICJ78_RS09890	COG1289	transmembrane transporter activity
ICJ78_RS09895	COG0402	S-adenosylhomocysteine deaminase activity
ICJ78_RS09905	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ICJ78_RS09910	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ICJ78_RS09915	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ICJ78_RS09920	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ICJ78_RS09935	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ICJ78_RS09945	COG0657	acetylesterase activity
ICJ78_RS09955	COG2001	Belongs to the MraZ family
ICJ78_RS09960	COG0275	rRNA processing
ICJ78_RS09975	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ICJ78_RS09980	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ICJ78_RS09985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ICJ78_RS09990	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ICJ78_RS10000	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ICJ78_RS10005	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ICJ78_RS10010	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ICJ78_RS10015	COG1181	Belongs to the D-alanine--D-alanine ligase family
ICJ78_RS10020	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ICJ78_RS10025	COG0849	cell division
ICJ78_RS10035	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ICJ78_RS10040	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ICJ78_RS10050	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ICJ78_RS10055	COG1744	ABC transporter substrate-binding protein PnrA-like
ICJ78_RS10060	COG3845	ABC transporter
ICJ78_RS10065	COG4603	Belongs to the binding-protein-dependent transport system permease family
ICJ78_RS10070	COG1079	Belongs to the binding-protein-dependent transport system permease family
ICJ78_RS10110	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ICJ78_RS10155	COG2244	polysaccharide biosynthetic process
ICJ78_RS10165	COG0741	lytic transglycosylase activity
ICJ78_RS10200	COG0513	Belongs to the DEAD box helicase family
ICJ78_RS10205	COG2813	Specifically methylates the guanine in position
ICJ78_RS10205	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ICJ78_RS10210	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ICJ78_RS10220	COG1136	(ABC) transporter
ICJ78_RS10230	COG0442	prolyl-tRNA aminoacylation
ICJ78_RS10245	COG1007	ATP synthesis coupled electron transport
ICJ78_RS10255	COG0713	ATP synthesis coupled electron transport
ICJ78_RS10265	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ICJ78_RS10270	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ICJ78_RS10275	COG1034	ATP synthesis coupled electron transport
ICJ78_RS10285	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ICJ78_RS10290	COG0649	NAD binding
ICJ78_RS10295	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ICJ78_RS10300	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ICJ78_RS10305	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ICJ78_RS10320	COG0776	regulation of translation
ICJ78_RS10330	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ICJ78_RS10335	COG0740	serine-type endopeptidase activity
ICJ78_RS10340	COG0544	peptidyl-prolyl cis-trans isomerase activity
ICJ78_RS10360	COG0513	Belongs to the DEAD box helicase family
ICJ78_RS10375	COG2151	metal-sulfur cluster biosynthetic enzyme
ICJ78_RS10385	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ICJ78_RS10390	COG0719	Fe-S assembly protein
ICJ78_RS10395	COG0396	ATPase activity
ICJ78_RS10400	COG0719	Fe-S assembly protein
ICJ78_RS10410	COG2733	membrane
ICJ78_RS10415	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ICJ78_RS10420	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ICJ78_RS10425	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ICJ78_RS10430	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ICJ78_RS10440	COG5265	(ABC) transporter
ICJ78_RS10455	COG0628	permease
ICJ78_RS10470	COG0776	regulation of translation
ICJ78_RS10475	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ICJ78_RS10480	COG0416	fatty acid biosynthetic process
ICJ78_RS10485	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ICJ78_RS10505	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ICJ78_RS10510	COG0242	peptide deformylase activity
ICJ78_RS10525	COG0745	RESPONSE REGULATOR receiver
ICJ78_RS10530	COG0473	3-isopropylmalate dehydrogenase activity
ICJ78_RS10535	COG0066	3-isopropylmalate dehydratase activity
ICJ78_RS10540	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ICJ78_RS10545	COG0335	large ribosomal subunit rRNA binding
ICJ78_RS10550	COG0336	Belongs to the RNA methyltransferase TrmD family
ICJ78_RS10555	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ICJ78_RS10560	COG0228	four-way junction DNA binding
ICJ78_RS10575	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ICJ78_RS10580	COG0581	inorganic phosphate transmembrane transporter activity
ICJ78_RS10585	COG0573	inorganic phosphate transmembrane transporter activity
ICJ78_RS10600	COG0328	RNA-DNA hybrid ribonuclease activity
ICJ78_RS10605	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ICJ78_RS10610	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ICJ78_RS10620	COG1297	OPT oligopeptide transporter protein
ICJ78_RS10635	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
ICJ78_RS10655	COG3265	gluconokinase activity
ICJ78_RS10670	COG0436	Aminotransferase
ICJ78_RS10680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ICJ78_RS10695	COG1032	radical SAM domain protein
ICJ78_RS10710	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ICJ78_RS10715	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ICJ78_RS10765	COG2884	Cell division ATP-binding protein ftsE
ICJ78_RS10785	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
ICJ78_RS10790	COG3547	Transposase (IS116 IS110 IS902 family)
ICJ78_RS10795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ICJ78_RS10805	COG0688	phosphatidylethanolamine metabolic process
ICJ78_RS10810	COG1183	phosphatidylcholine synthase activity
ICJ78_RS10815	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ICJ78_RS10845	COG0656	L-ascorbic acid biosynthetic process
ICJ78_RS10855	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ICJ78_RS10865	COG0009	L-threonylcarbamoyladenylate synthase
ICJ78_RS10875	COG0277	FAD linked oxidase domain protein
ICJ78_RS10890	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ICJ78_RS10900	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ICJ78_RS10905	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ICJ78_RS10910	COG0359	binds to the 23S rRNA
ICJ78_RS10915	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ICJ78_RS10920	COG0360	Binds together with S18 to 16S ribosomal RNA
ICJ78_RS10935	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ICJ78_RS10950	COG0505	Belongs to the CarA family
ICJ78_RS10955	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ICJ78_RS10960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ICJ78_RS10965	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ICJ78_RS10970	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ICJ78_RS10975	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ICJ78_RS10980	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ICJ78_RS10990	COG0793	Belongs to the peptidase S41A family
ICJ78_RS10995	COG1051	belongs to the nudix hydrolase family
ICJ78_RS11005	COG2814	Major facilitator Superfamily
ICJ78_RS11010	COG1566	PFAM secretion protein HlyD family protein
ICJ78_RS11015	COG1132	(ABC) transporter
ICJ78_RS11030	COG0714	Associated with various cellular activities
ICJ78_RS11060	COG2189	Belongs to the N(4) N(6)-methyltransferase family
ICJ78_RS11065	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ICJ78_RS11075	COG0477	Major facilitator Superfamily
ICJ78_RS11100	COG5487	UPF0391 membrane protein
ICJ78_RS11110	COG1116	anion transmembrane transporter activity
ICJ78_RS11125	COG0203	ribosomal protein L17
ICJ78_RS11130	COG0202	RNA polymerase activity
ICJ78_RS11135	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ICJ78_RS11140	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ICJ78_RS11145	COG0563	adenylate kinase activity
ICJ78_RS11150	COG0201	protein transport
ICJ78_RS11155	COG0200	Binds to the 23S rRNA
ICJ78_RS11160	COG1841	ribosomal large subunit assembly
ICJ78_RS11165	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ICJ78_RS11170	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ICJ78_RS11175	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ICJ78_RS11180	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ICJ78_RS11185	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ICJ78_RS11190	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ICJ78_RS11195	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ICJ78_RS11200	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ICJ78_RS11205	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ICJ78_RS11210	COG0255	Belongs to the universal ribosomal protein uL29 family
ICJ78_RS11215	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ICJ78_RS11220	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ICJ78_RS11225	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ICJ78_RS11230	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ICJ78_RS11235	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ICJ78_RS11240	COG0089	rRNA binding
ICJ78_RS11245	COG0088	Forms part of the polypeptide exit tunnel
ICJ78_RS11250	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ICJ78_RS11255	COG0051	transcription antitermination factor activity, RNA binding
ICJ78_RS11260	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ICJ78_RS11265	COG0049	tRNA binding
ICJ78_RS11270	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ICJ78_RS11275	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ICJ78_RS11280	COG0085	RNA polymerase activity
ICJ78_RS11285	COG0222	ribosome binding
ICJ78_RS11290	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ICJ78_RS11295	COG0081	regulation of translation
ICJ78_RS11300	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ICJ78_RS11330	COG1322	Protein conserved in bacteria
ICJ78_RS11335	COG1301	dicarboxylic acid transport
ICJ78_RS11340	COG0477	Major facilitator Superfamily
ICJ78_RS11350	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ICJ78_RS11375	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ICJ78_RS11405	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ICJ78_RS11415	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ICJ78_RS11420	COG1138	Cytochrome C-type biogenesis protein
ICJ78_RS11425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ICJ78_RS11430	COG3088	subunit of a heme lyase
ICJ78_RS11455	COG0612	Peptidase, M16
ICJ78_RS11460	COG0539	negative regulation of cytoplasmic translation
ICJ78_RS11465	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ICJ78_RS11470	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ICJ78_RS11485	COG1028	Short-chain dehydrogenase reductase Sdr
ICJ78_RS11490	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ICJ78_RS11495	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ICJ78_RS11500	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ICJ78_RS11515	COG0024	Methionine aminopeptidase
ICJ78_RS11520	COG1686	Belongs to the peptidase S11 family
ICJ78_RS11535	COG1742	UPF0060 membrane protein
ICJ78_RS11545	COG2326	polyphosphate kinase activity
ICJ78_RS11550	COG4221	oxidoreductase activity
ICJ78_RS11555	COG1678	Uncharacterized ACR, COG1678
ICJ78_RS11565	COG0167	dihydroorotate dehydrogenase activity
ICJ78_RS11595	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
ICJ78_RS11600	COG1492	cobalamin metabolic process
ICJ78_RS11615	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ICJ78_RS11620	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
ICJ78_RS11625	COG0406	alpha-ribazole phosphatase activity
ICJ78_RS11640	COG1113	amino acid transport
ICJ78_RS11650	COG0252	asparaginase activity
ICJ78_RS11660	COG2814	Major facilitator Superfamily
ICJ78_RS11665	COG3961	Belongs to the TPP enzyme family
ICJ78_RS11675	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ICJ78_RS11680	COG0574	Belongs to the PEP-utilizing enzyme family
ICJ78_RS11680	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ICJ78_RS11700	COG1959	2 iron, 2 sulfur cluster binding
ICJ78_RS11705	COG1012	belongs to the aldehyde dehydrogenase family
ICJ78_RS11750	COG0488	(ABC) transporter
ICJ78_RS11760	COG1937	Protein conserved in bacteria
ICJ78_RS11770	COG2132	Multicopper oxidase
ICJ78_RS11790	COG1956	GAF domain-containing protein
ICJ78_RS11800	COG3284	Transcriptional regulator
ICJ78_RS11805	COG3585	molybdate ion transport
ICJ78_RS11810	COG1252	NADH dehydrogenase
ICJ78_RS11815	COG1012	belongs to the aldehyde dehydrogenase family
ICJ78_RS11840	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ICJ78_RS11855	COG2814	Major facilitator Superfamily
ICJ78_RS11865	COG1414	Transcriptional regulator
ICJ78_RS11870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ICJ78_RS11880	COG0604	alcohol dehydrogenase
ICJ78_RS11890	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ICJ78_RS11895	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ICJ78_RS11900	COG1609	Transcriptional regulator
ICJ78_RS11905	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ICJ78_RS11910	COG2814	Major facilitator Superfamily
ICJ78_RS11925	COG4303	Ethanolamine ammonia lyase large subunit
ICJ78_RS11960	COG3189	MarR family transcriptional regulator
ICJ78_RS11970	COG1959	2 iron, 2 sulfur cluster binding
ICJ78_RS11995	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ICJ78_RS12000	COG0431	NADPH-dependent FMN reductase
ICJ78_RS12005	COG2072	flavoprotein involved in K transport
ICJ78_RS12010	COG1733	regulation of RNA biosynthetic process
ICJ78_RS12015	COG1902	pentaerythritol trinitrate reductase activity
ICJ78_RS12020	COG1012	belongs to the aldehyde dehydrogenase family
ICJ78_RS12120	COG0778	Nitroreductase
ICJ78_RS12125	COG0131	Imidazoleglycerol-phosphate dehydratase
ICJ78_RS12135	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ICJ78_RS12140	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ICJ78_RS12145	COG0107	imidazoleglycerol-phosphate synthase activity
ICJ78_RS12150	COG0140	phosphoribosyl-ATP diphosphatase activity
ICJ78_RS12160	COG5265	(ABC) transporter
ICJ78_RS12165	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ICJ78_RS12175	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ICJ78_RS12180	COG0540	Belongs to the ATCase OTCase family
ICJ78_RS12185	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ICJ78_RS12190	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ICJ78_RS12195	COG0758	DNA mediated transformation
ICJ78_RS12200	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ICJ78_RS12205	COG0557	exoribonuclease II activity
ICJ78_RS12210	COG0793	Belongs to the peptidase S41A family
ICJ78_RS12220	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ICJ78_RS12220	COG2885	chlorophyll binding
ICJ78_RS12225	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ICJ78_RS12230	COG1959	2 iron, 2 sulfur cluster binding
ICJ78_RS12245	COG0187	DNA topoisomerase II activity
ICJ78_RS12255	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ICJ78_RS12265	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ICJ78_RS12270	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ICJ78_RS12275	COG0196	riboflavin kinase activity
ICJ78_RS12280	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
ICJ78_RS12285	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
ICJ78_RS12290	COG0235	Class ii aldolase
ICJ78_RS12295	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ICJ78_RS12310	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ICJ78_RS12315	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ICJ78_RS12335	COG4232	protein-disulfide reductase activity
ICJ78_RS12340	COG1643	Atp-dependent helicase
ICJ78_RS12345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ICJ78_RS12355	COG5002	protein histidine kinase activity
ICJ78_RS12370	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ICJ78_RS12375	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ICJ78_RS12380	COG0859	PFAM glycosyl transferase family 9
ICJ78_RS12405	COG0717	Belongs to the dCTP deaminase family
ICJ78_RS12410	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ICJ78_RS12415	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ICJ78_RS12420	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ICJ78_RS12425	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ICJ78_RS12430	COG0424	maF-like protein
ICJ78_RS12440	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
ICJ78_RS12450	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ICJ78_RS12455	COG2202	Pas domain
ICJ78_RS12455	COG2200	EAL domain
ICJ78_RS12455	COG2199	diguanylate cyclase activity
ICJ78_RS12460	COG2199	diguanylate cyclase activity
ICJ78_RS12460	COG2202	Pas domain
ICJ78_RS12460	COG2200	EAL domain
ICJ78_RS12470	COG3300	MHYT domain
ICJ78_RS12470	COG5001	Diguanylate cyclase
ICJ78_RS12495	COG0740	serine-type endopeptidase activity
ICJ78_RS12505	COG0436	Aminotransferase
ICJ78_RS12540	COG1522	sequence-specific DNA binding
ICJ78_RS12560	COG2188	Transcriptional regulator
ICJ78_RS12570	COG2309	aminopeptidase activity
ICJ78_RS12595	COG0667	Aldo Keto reductase
ICJ78_RS12600	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ICJ78_RS12615	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ICJ78_RS12620	COG0732	type I restriction modification DNA specificity domain
ICJ78_RS12625	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ICJ78_RS12655	COG2176	DNA-directed DNA polymerase activity
ICJ78_RS12670	COG1132	(ABC) transporter
ICJ78_RS12680	COG1321	iron dependent repressor
ICJ78_RS12685	COG0450	alkyl hydroperoxide reductase
ICJ78_RS12695	COG0446	pyridine nucleotide-disulphide oxidoreductase
ICJ78_RS12705	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ICJ78_RS12735	COG0351	phosphomethylpyrimidine kinase
ICJ78_RS12735	COG0352	thiamine-phosphate diphosphorylase activity
ICJ78_RS12740	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ICJ78_RS12745	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ICJ78_RS12755	COG0037	tRNA processing
ICJ78_RS12765	COG2885	chlorophyll binding
ICJ78_RS12770	COG0823	Involved in the tonB-independent uptake of proteins
ICJ78_RS12790	COG0824	Thioesterase
ICJ78_RS12795	COG2255	four-way junction helicase activity
ICJ78_RS12800	COG0632	four-way junction helicase activity
ICJ78_RS12805	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ICJ78_RS12810	COG0217	transcriptional regulatory protein
ICJ78_RS12815	COG0653	protein targeting
ICJ78_RS12820	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ICJ78_RS12825	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ICJ78_RS12830	COG1714	RDD family
ICJ78_RS12835	COG0668	transmembrane transport
ICJ78_RS12850	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ICJ78_RS12855	COG1127	ABC transporter
ICJ78_RS12880	COG4957	zinc ion binding
ICJ78_RS12890	COG0625	glutathione transferase activity
ICJ78_RS12900	COG0625	glutathione transferase activity
ICJ78_RS12925	COG0439	Biotin carboxylase
ICJ78_RS12940	COG0582	viral genome integration into host DNA
ICJ78_RS12955	COG2967	ApaG domain
ICJ78_RS12960	COG0302	gtp cyclohydrolase
ICJ78_RS12970	COG0521	Mo-molybdopterin cofactor biosynthetic process
ICJ78_RS12990	COG0494	nUDIX hydrolase
ICJ78_RS12995	COG3961	Belongs to the TPP enzyme family
ICJ78_RS13000	COG0277	FAD linked oxidase domain protein
ICJ78_RS13010	COG3527	Alpha-acetolactate decarboxylase
ICJ78_RS13025	COG0484	heat shock protein binding
ICJ78_RS13030	COG0025	NhaP-type Na H and K H
ICJ78_RS13040	COG0667	Aldo Keto reductase
ICJ78_RS13090	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ICJ78_RS13095	COG0457	Tetratricopeptide repeat
ICJ78_RS13100	COG1573	uracil-dna glycosylase
ICJ78_RS13110	COG1253	flavin adenine dinucleotide binding
ICJ78_RS13115	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ICJ78_RS13120	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ICJ78_RS13140	COG3394	polysaccharide catabolic process
ICJ78_RS13150	COG1074	ATP-dependent DNA helicase activity
ICJ78_RS13155	COG2887	Belongs to the helicase family. UvrD subfamily
ICJ78_RS13160	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ICJ78_RS13170	COG0492	ferredoxin-NADP+ reductase activity
ICJ78_RS13175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ICJ78_RS13185	COG1217	gtp-binding protein TYPA
ICJ78_RS13190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ICJ78_RS13205	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ICJ78_RS13210	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ICJ78_RS13215	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ICJ78_RS13220	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ICJ78_RS13225	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ICJ78_RS13230	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ICJ78_RS13235	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ICJ78_RS13255	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ICJ78_RS13270	COG3008	intermembrane lipid transfer
ICJ78_RS13275	COG2995	paraquat-inducible protein a
ICJ78_RS13285	COG2610	gluconate transmembrane transporter activity
ICJ78_RS13295	COG0842	Transport permease protein
ICJ78_RS13300	COG0842	Transport permease protein
ICJ78_RS13300	COG1129	ABC transporter
ICJ78_RS13305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ICJ78_RS13345	COG0038	chloride channel
ICJ78_RS13350	COG0347	Belongs to the P(II) protein family
ICJ78_RS13355	COG0004	ammonium transporteR
ICJ78_RS13395	COG2202	Pas domain
ICJ78_RS13395	COG2200	EAL domain
ICJ78_RS13395	COG2199	diguanylate cyclase activity
ICJ78_RS13425	COG0656	L-ascorbic acid biosynthetic process
ICJ78_RS13435	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ICJ78_RS13470	COG0583	DNA-binding transcription factor activity
ICJ78_RS13495	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ICJ78_RS13530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ICJ78_RS13540	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ICJ78_RS13570	COG2835	tetraacyldisaccharide 4'-kinase activity
ICJ78_RS13575	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ICJ78_RS13585	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ICJ78_RS13585	COG1648	precorrin-2 dehydrogenase activity
ICJ78_RS13650	COG2610	gluconate transmembrane transporter activity
ICJ78_RS13745	COG2194	sulfuric ester hydrolase activity
ICJ78_RS13750	COG0538	isocitrate dehydrogenase activity
ICJ78_RS13755	COG1301	dicarboxylic acid transport
ICJ78_RS13760	COG1959	2 iron, 2 sulfur cluster binding
ICJ78_RS13765	COG0586	Pfam SNARE associated Golgi protein
ICJ78_RS13770	COG0778	Nitroreductase
ICJ78_RS13810	COG0251	oxidation-reduction process
ICJ78_RS13815	COG1289	transmembrane transporter activity
ICJ78_RS13820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ICJ78_RS13845	COG2200	EAL domain
ICJ78_RS13845	COG2199	diguanylate cyclase activity
ICJ78_RS13845	COG2202	Pas domain
ICJ78_RS13855	COG0584	glycerophosphoryl diester phosphodiesterase
ICJ78_RS13860	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ICJ78_RS13880	COG0242	peptide deformylase activity
ICJ78_RS13890	COG0745	RESPONSE REGULATOR receiver
ICJ78_RS13900	COG2211	Major facilitator Superfamily
ICJ78_RS13905	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ICJ78_RS13920	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ICJ78_RS13950	COG0723	plastoquinol--plastocyanin reductase activity
ICJ78_RS13960	COG2999	glutathione oxidoreductase activity
ICJ78_RS13975	COG0415	Belongs to the DNA photolyase family
ICJ78_RS13990	COG1028	Short-chain dehydrogenase reductase Sdr
ICJ78_RS14005	COG0114	fumarate hydratase activity
ICJ78_RS14010	COG1280	lysine exporter protein (LysE YggA)
ICJ78_RS14020	COG1121	(ABC) transporter
ICJ78_RS14030	COG0803	Belongs to the bacterial solute-binding protein 9 family
ICJ78_RS14035	COG4178	(ABC) transporter
ICJ78_RS14045	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ICJ78_RS14055	COG3547	Transposase (IS116 IS110 IS902 family)
ICJ78_RS14065	COG1472	Belongs to the glycosyl hydrolase 3 family
ICJ78_RS14080	COG0747	negative chemotaxis
ICJ78_RS14085	COG1999	signal sequence binding
ICJ78_RS14090	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ICJ78_RS14090	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ICJ78_RS14100	COG0596	Alpha beta hydrolase
ICJ78_RS14100	COG0508	dehydrogenase complex catalyzes the overall conversion of
ICJ78_RS14125	COG0659	secondary active sulfate transmembrane transporter activity
ICJ78_RS14165	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ICJ78_RS14175	COG1228	amidohydrolase
ICJ78_RS14220	COG0667	Aldo Keto reductase
ICJ78_RS14225	COG0179	Fumarylacetoacetate (FAA) hydrolase
ICJ78_RS14230	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ICJ78_RS14240	COG0028	Belongs to the TPP enzyme family
ICJ78_RS14245	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ICJ78_RS14250	COG0560	Phosphoserine phosphatase
ICJ78_RS14250	COG3830	Belongs to the UPF0237 family
ICJ78_RS14260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ICJ78_RS14275	COG2983	Belongs to the UPF0260 family
ICJ78_RS14290	COG3842	ATPase activity
ICJ78_RS14315	COG1566	PFAM secretion protein HlyD family protein
ICJ78_RS14335	COG2235	arginine
ICJ78_RS14345	COG0765	amino acid transport
ICJ78_RS14350	COG1126	abc transporter atp-binding protein
ICJ78_RS14360	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
ICJ78_RS14365	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ICJ78_RS14375	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ICJ78_RS14380	COG1562	ergosterol biosynthetic process
ICJ78_RS14385	COG1562	ergosterol biosynthetic process
ICJ78_RS14395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ICJ78_RS14405	COG0287	Prephenate dehydrogenase
ICJ78_RS14410	COG0469	pyruvate kinase activity
ICJ78_RS14425	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ICJ78_RS14450	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ICJ78_RS14465	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ICJ78_RS14465	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ICJ78_RS14470	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ICJ78_RS14500	COG1127	ABC transporter
ICJ78_RS14505	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ICJ78_RS14515	COG3547	Transposase (IS116 IS110 IS902 family)
ICJ78_RS14520	COG2814	Major facilitator Superfamily
ICJ78_RS14525	COG0194	GDP metabolic process
ICJ78_RS14530	COG0300	oxidoreductase activity
ICJ78_RS14545	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ICJ78_RS14565	COG0673	inositol 2-dehydrogenase activity
ICJ78_RS14570	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ICJ78_RS14580	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ICJ78_RS14585	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ICJ78_RS14590	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ICJ78_RS14595	COG0356	it plays a direct role in the translocation of protons across the membrane
ICJ78_RS14610	COG0138	bifunctional purine biosynthesis protein purh
ICJ78_RS14625	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ICJ78_RS14625	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ICJ78_RS14635	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ICJ78_RS14640	COG1660	Displays ATPase and GTPase activities
ICJ78_RS14645	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ICJ78_RS14670	COG1981	membrane
ICJ78_RS14675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ICJ78_RS14680	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ICJ78_RS14685	COG0424	maF-like protein
ICJ78_RS14735	COG3453	Protein conserved in bacteria
ICJ78_RS14735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ICJ78_RS14740	COG4988	ABC transporter
ICJ78_RS14745	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ICJ78_RS14750	COG1271	oxidase subunit
ICJ78_RS14755	COG1294	oxidase, subunit
ICJ78_RS14780	COG2271	Major facilitator Superfamily
ICJ78_RS14825	COG0583	DNA-binding transcription factor activity
ICJ78_RS14835	COG2072	flavoprotein involved in K transport
ICJ78_RS14850	COG2144	transferase activity, transferring acyl groups
ICJ78_RS14875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ICJ78_RS14880	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ICJ78_RS14890	COG1028	Short-chain dehydrogenase reductase Sdr
ICJ78_RS14895	COG2814	Major facilitator Superfamily
ICJ78_RS14900	COG2376	Dihydroxyacetone kinase
ICJ78_RS14905	COG0698	ribose 5-phosphate isomerase
ICJ78_RS14915	COG0697	spore germination
ICJ78_RS14935	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ICJ78_RS14940	COG2814	Major facilitator Superfamily
ICJ78_RS14950	COG1028	Short-chain dehydrogenase reductase Sdr
ICJ78_RS14965	COG0668	transmembrane transport
ICJ78_RS15005	COG0583	DNA-binding transcription factor activity
ICJ78_RS15015	COG0583	DNA-binding transcription factor activity
ICJ78_RS15065	COG0629	single-stranded DNA binding
ICJ78_RS15080	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ICJ78_RS15100	COG1733	regulation of RNA biosynthetic process
ICJ78_RS15270	COG3547	Transposase (IS116 IS110 IS902 family)
ICJ78_RS15320	COG4115	mRNA cleavage
ICJ78_RS15325	COG2161	toxin-antitoxin pair type II binding
ICJ78_RS15365	COG4957	zinc ion binding
ICJ78_RS15385	COG1487	ribonuclease activity
ICJ78_RS15480	COG3210	domain, Protein
ICJ78_RS15510	COG3550	peptidyl-serine autophosphorylation
ICJ78_RS15525	COG1522	sequence-specific DNA binding
ICJ78_RS15555	COG0625	glutathione transferase activity
ICJ78_RS15560	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ICJ78_RS15570	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
ICJ78_RS15575	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ICJ78_RS15585	COG1609	Transcriptional regulator
ICJ78_RS15600	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ICJ78_RS15640	COG2226	methyltransferase
ICJ78_RS15645	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ICJ78_RS15675	COG3290	protein histidine kinase activity
ICJ78_RS15705	COG1271	oxidase subunit
ICJ78_RS15710	COG1294	oxidase, subunit
ICJ78_RS15720	COG0243	molybdopterin cofactor binding
ICJ78_RS15725	COG0746	molybdenum cofactor guanylyltransferase activity
ICJ78_RS15725	COG0315	cyclic pyranopterin monophosphate synthase activity
ICJ78_RS15730	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ICJ78_RS15765	COG3210	domain, Protein
ICJ78_RS15795	COG2205	protein histidine kinase activity
ICJ78_RS15830	COG1032	radical SAM domain protein
ICJ78_RS15835	COG0431	NADPH-dependent FMN reductase
ICJ78_RS15850	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ICJ78_RS15855	COG0390	transport system, permease component
ICJ78_RS15885	COG0583	DNA-binding transcription factor activity
ICJ78_RS15890	COG1028	Short-chain dehydrogenase reductase Sdr
ICJ78_RS15900	COG0300	oxidoreductase activity
ICJ78_RS15910	COG0583	DNA-binding transcription factor activity
ICJ78_RS15915	COG0583	DNA-binding transcription factor activity
ICJ78_RS15920	COG1902	pentaerythritol trinitrate reductase activity
ICJ78_RS15930	COG0583	DNA-binding transcription factor activity
ICJ78_RS15935	COG4221	oxidoreductase activity
ICJ78_RS15940	COG4221	oxidoreductase activity
ICJ78_RS15950	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ICJ78_RS15990	COG2942	2-epimerase
ICJ78_RS16000	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ICJ78_RS16010	COG1216	Glycosyl transferase, family 2
ICJ78_RS16010	COG0438	transferase activity, transferring glycosyl groups
ICJ78_RS16015	COG1309	transcriptional regulator
ICJ78_RS16020	COG0625	glutathione transferase activity
ICJ78_RS16025	COG0625	glutathione transferase activity
ICJ78_RS16035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ICJ78_RS16095	COG3609	addiction module antidote protein, CC2985 family
ICJ78_RS16125	COG4221	oxidoreductase activity
ICJ78_RS16140	COG1335	isochorismatase
ICJ78_RS16145	COG1309	transcriptional regulator
ICJ78_RS16150	COG0596	Alpha beta hydrolase
ICJ78_RS16225	COG1140	nitrate reductase beta subunit
ICJ78_RS16235	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
ICJ78_RS16240	COG2181	nitrate reductase activity
ICJ78_RS16260	COG2948	multi-organism process
ICJ78_RS16315	COG4962	Type ii secretion system protein e
ICJ78_RS16340	COG3609	addiction module antidote protein, CC2985 family
ICJ78_RS16415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ICJ78_RS16435	COG3189	MarR family transcriptional regulator
ICJ78_RS16445	COG2223	nitrite transmembrane transporter activity
ICJ78_RS16455	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ICJ78_RS16455	COG2146	nitrite reductase [NAD(P)H] activity
ICJ78_RS16460	COG0243	molybdopterin cofactor binding
ICJ78_RS16470	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ICJ78_RS16480	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ICJ78_RS16490	COG4974	Belongs to the 'phage' integrase family
ICJ78_RS16540	COG3609	addiction module antidote protein, CC2985 family
ICJ78_RS16635	COG0776	regulation of translation
ICJ78_RS16655	COG1695	Transcriptional regulator
ICJ78_RS16675	COG3189	MarR family transcriptional regulator
ICJ78_RS16700	COG3177	Filamentation induced by cAMP protein fic
ICJ78_RS16710	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ICJ78_RS16760	COG3077	Addiction module antitoxin, RelB DinJ family
ICJ78_RS16765	COG3041	Addiction module toxin RelE StbE family
ICJ78_RS16895	COG1487	ribonuclease activity
ICJ78_RS16900	COG4691	Plasmid stability protein
ICJ78_RS17020	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ICJ78_RS17030	COG3177	Filamentation induced by cAMP protein fic
ICJ78_RS17040	COG0587	DNA-directed DNA polymerase activity
ICJ78_RS17050	COG3077	Addiction module antitoxin, RelB DinJ family
ICJ78_RS17055	COG3041	Addiction module toxin RelE StbE family