locus-tag	class	description
CD178_RS00075	COG3217	Mosc domain protein beta barrel domain protein
CD178_RS00075	COG0633	Ferredoxin
CD178_RS00085	COG4615	Cyclic peptide transporter
CD178_RS00090	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
CD178_RS00105	COG4372	Transposase
CD178_RS00130	COG0626	cystathionine gamma-synthase activity
CD178_RS00145	COG4774	siderophore transport
CD178_RS00200	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CD178_RS00230	COG3451	type IV secretory pathway VirB4
CD178_RS00340	COG4372	Transposase
CD178_RS00365	COG4974	Belongs to the 'phage' integrase family
CD178_RS00375	COG4771	TonB-dependent receptor
CD178_RS00400	COG1858	cytochrome C peroxidase
CD178_RS00410	COG2372	response to copper ion
CD178_RS00420	COG0583	DNA-binding transcription factor activity
CD178_RS00455	COG3451	type IV secretory pathway VirB4
CD178_RS00465	COG3838	Conjugal transfer protein Trbc
CD178_RS00470	COG4962	Type ii secretion system protein e
CD178_RS00500	COG1196	nuclear chromosome segregation
CD178_RS00500	COG0741	lytic transglycosylase activity
CD178_RS00500	COG0739	heme binding
CD178_RS00525	COG1192	Involved in chromosome partitioning
CD178_RS00560	COG5489	Protein of unknown function (DUF736)
CD178_RS00600	COG3621	Patatin-like phospholipase
CD178_RS00620	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CD178_RS00630	COG2814	Major facilitator Superfamily
CD178_RS00635	COG0583	DNA-binding transcription factor activity
CD178_RS00675	COG0318	PFAM AMP-dependent synthetase and ligase
CD178_RS00685	COG0156	8-amino-7-oxononanoate synthase activity
CD178_RS00730	COG0483	inositol monophosphate 1-phosphatase activity
CD178_RS00740	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CD178_RS00745	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CD178_RS00750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CD178_RS00760	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CD178_RS00770	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CD178_RS00790	COG0045	succinate-CoA ligase (ADP-forming) activity
CD178_RS00800	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CD178_RS00805	COG0602	queuosine metabolic process
CD178_RS00810	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CD178_RS00820	COG0659	secondary active sulfate transmembrane transporter activity
CD178_RS00835	COG1136	(ABC) transporter
CD178_RS00850	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CD178_RS00855	COG0237	dephospho-CoA kinase activity
CD178_RS00860	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CD178_RS00870	COG0165	Argininosuccinate lyase
CD178_RS00875	COG0295	cytidine deaminase activity
CD178_RS00880	COG0019	diaminopimelate decarboxylase activity
CD178_RS00900	COG2022	thiamine diphosphate biosynthetic process
CD178_RS00915	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CD178_RS00920	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CD178_RS00925	COG0546	phosphoglycolate phosphatase activity
CD178_RS00935	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CD178_RS00945	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CD178_RS00950	COG0268	Binds directly to 16S ribosomal RNA
CD178_RS00955	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CD178_RS00960	COG2226	methyltransferase
CD178_RS00970	COG0756	dUTP diphosphatase activity
CD178_RS00975	COG0395	ABC-type sugar transport system, permease component
CD178_RS00980	COG1116	anion transmembrane transporter activity
CD178_RS00985	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CD178_RS00990	COG0525	valine-tRNA ligase activity
CD178_RS01000	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CD178_RS01015	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CD178_RS01020	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CD178_RS01030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CD178_RS01050	COG5564	TIM-barrel signal transduction protein
CD178_RS01065	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CD178_RS01065	COG0506	proline dehydrogenase activity
CD178_RS01065	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CD178_RS01075	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CD178_RS01080	COG2814	Major facilitator Superfamily
CD178_RS01090	COG1070	Carbohydrate kinase
CD178_RS01100	COG0022	dehydrogenase e1 component
CD178_RS01105	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CD178_RS01110	COG3284	Transcriptional regulator
CD178_RS01115	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CD178_RS01120	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CD178_RS01125	COG1028	Short-chain dehydrogenase reductase Sdr
CD178_RS01130	COG0504	CTP synthase activity
CD178_RS01135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CD178_RS01140	COG0006	proline dipeptidase activity
CD178_RS01145	COG4948	Mandelate Racemase Muconate Lactonizing
CD178_RS01150	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CD178_RS01160	COG0765	amino acid transport
CD178_RS01180	COG3938	Belongs to the proline racemase family
CD178_RS01190	COG1309	transcriptional regulator
CD178_RS01195	COG2353	YceI-like domain
CD178_RS01205	COG3237	CsbD-like
CD178_RS01220	COG1309	transcriptional regulator
CD178_RS01230	COG1172	Belongs to the binding-protein-dependent transport system permease family
CD178_RS01235	COG1129	ABC transporter
CD178_RS01240	COG1172	Belongs to the binding-protein-dependent transport system permease family
CD178_RS01275	COG1028	Short-chain dehydrogenase reductase Sdr
CD178_RS01285	COG1012	belongs to the aldehyde dehydrogenase family
CD178_RS01315	COG0436	Aminotransferase
CD178_RS01330	COG0511	ligase activity, forming carbon-carbon bonds
CD178_RS01335	COG4221	oxidoreductase activity
CD178_RS01345	COG1984	allophanate hydrolase subunit 2
CD178_RS01350	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CD178_RS01355	COG0697	spore germination
CD178_RS01360	COG2271	Major facilitator Superfamily
CD178_RS01395	COG3511	phospholipase C
CD178_RS01410	COG2207	Transcriptional regulator
CD178_RS01430	COG1309	transcriptional regulator
CD178_RS01450	COG1811	Na channel or pump
CD178_RS01460	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CD178_RS01465	COG0583	DNA-binding transcription factor activity
CD178_RS01490	COG1309	transcriptional regulator
CD178_RS01495	COG1028	Short-chain dehydrogenase reductase Sdr
CD178_RS01530	COG2207	Transcriptional regulator
CD178_RS01630	COG0837	glucose binding
CD178_RS01645	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CD178_RS01650	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CD178_RS01655	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CD178_RS01660	COG0514	ATP-dependent DNA helicase (RecQ)
CD178_RS01670	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CD178_RS01675	COG4988	ABC transporter
CD178_RS01700	COG0784	Response regulator, receiver
CD178_RS01705	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CD178_RS01710	COG0488	(ABC) transporter
CD178_RS01725	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CD178_RS01740	COG1970	mechanosensitive ion channel activity
CD178_RS01750	COG0254	rRNA binding
CD178_RS01755	COG0071	Belongs to the small heat shock protein (HSP20) family
CD178_RS01775	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CD178_RS01780	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CD178_RS01785	COG2003	Belongs to the UPF0758 family
CD178_RS01795	COG2003	Belongs to the UPF0758 family
CD178_RS01800	COG0210	DNA helicase
CD178_RS01805	COG2264	protein methyltransferase activity
CD178_RS01815	COG0006	proline dipeptidase activity
CD178_RS01820	COG0473	3-isopropylmalate dehydrogenase activity
CD178_RS01825	COG2351	hydroxyisourate hydrolase activity
CD178_RS01840	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CD178_RS01865	COG2072	flavoprotein involved in K transport
CD178_RS01870	COG0583	DNA-binding transcription factor activity
CD178_RS01880	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CD178_RS01885	COG2080	2 iron, 2 sulfur cluster binding
CD178_RS01900	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CD178_RS01910	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CD178_RS01915	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CD178_RS01920	COG0105	UTP biosynthetic process
CD178_RS01925	COG0488	(ABC) transporter
CD178_RS01930	COG2814	Major facilitator Superfamily
CD178_RS01955	COG1086	Polysaccharide biosynthesis protein
CD178_RS01960	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CD178_RS01975	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CD178_RS01995	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CD178_RS02015	COG0670	Belongs to the BI1 family
CD178_RS02040	COG1573	uracil-dna glycosylase
CD178_RS02045	COG2095	MarC family integral membrane protein
CD178_RS02060	COG1199	ATP-dependent helicase activity
CD178_RS02065	COG1278	Cold shock
CD178_RS02070	COG0459	protein refolding
CD178_RS02075	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CD178_RS02080	COG0412	Dienelactone hydrolase
CD178_RS02090	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CD178_RS02095	COG2857	Cytochrome c1
CD178_RS02095	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CD178_RS02100	COG0408	coproporphyrinogen oxidase activity
CD178_RS02115	COG1858	cytochrome C peroxidase
CD178_RS02120	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CD178_RS02135	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CD178_RS02145	COG0181	hydroxymethylbilane synthase activity
CD178_RS02150	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CD178_RS02155	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CD178_RS02160	COG0386	Belongs to the glutathione peroxidase family
CD178_RS02165	COG0728	peptidoglycan biosynthetic process
CD178_RS02170	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CD178_RS02175	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CD178_RS02185	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CD178_RS02200	COG0612	Peptidase, M16
CD178_RS02205	COG0312	modulator of DNA gyrase
CD178_RS02220	COG0109	protoheme IX farnesyltransferase activity
CD178_RS02225	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CD178_RS02240	COG0189	ligase activity
CD178_RS02255	COG0556	nucleotide-excision repair
CD178_RS02260	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CD178_RS02310	COG1137	ATPase activity
CD178_RS02315	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CD178_RS02330	COG0242	peptide deformylase activity
CD178_RS02335	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CD178_RS02340	COG0101	tRNA pseudouridine synthase activity
CD178_RS02355	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CD178_RS02360	COG2171	N-acyltransferase activity
CD178_RS02365	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CD178_RS02370	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CD178_RS02375	COG0706	membrane insertase activity
CD178_RS02380	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CD178_RS02385	COG0594	ribonuclease P activity
CD178_RS02390	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CD178_RS02400	COG0346	lactoylglutathione lyase activity
CD178_RS02405	COG3494	Protein of unknown function (DUF1009)
CD178_RS02410	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CD178_RS02415	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CD178_RS02420	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CD178_RS02430	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CD178_RS02435	COG0750	zinc metalloprotease
CD178_RS02440	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CD178_RS02450	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CD178_RS02455	COG0233	cytoplasmic translational termination
CD178_RS02460	COG0528	UMP kinase activity
CD178_RS02465	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CD178_RS02475	COG0681	Belongs to the peptidase S26 family
CD178_RS02480	COG0736	holo-[acyl-carrier-protein] synthase activity
CD178_RS02490	COG1758	RNA polymerase activity
CD178_RS02540	COG1862	Preprotein translocase
CD178_RS02565	COG1058	Belongs to the CinA family
CD178_RS02565	COG1546	Belongs to the CinA family
CD178_RS02570	COG0825	malonyl-CoA metabolic process
CD178_RS02575	COG4974	Belongs to the 'phage' integrase family
CD178_RS02585	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CD178_RS02590	COG2885	chlorophyll binding
CD178_RS02590	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CD178_RS02595	COG2885	chlorophyll binding
CD178_RS02595	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CD178_RS02600	COG2885	chlorophyll binding
CD178_RS02600	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CD178_RS02610	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CD178_RS02615	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CD178_RS02645	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CD178_RS02650	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CD178_RS02655	COG0215	cysteine-tRNA ligase activity
CD178_RS02665	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CD178_RS02680	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CD178_RS02705	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CD178_RS02710	COG0805	protein transport
CD178_RS02715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CD178_RS02720	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CD178_RS02725	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CD178_RS02735	COG0018	arginyl-trna synthetase
CD178_RS02740	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CD178_RS02745	COG0316	Belongs to the HesB IscA family
CD178_RS02750	COG0708	Exodeoxyribonuclease III
CD178_RS02760	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CD178_RS02765	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CD178_RS02775	COG0326	Molecular chaperone. Has ATPase activity
CD178_RS02780	COG1051	belongs to the nudix hydrolase family
CD178_RS02790	COG3161	chorismate lyase activity
CD178_RS02845	COG0564	pseudouridine synthase activity
CD178_RS02855	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CD178_RS02860	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CD178_RS02880	COG3956	TIGRFAM MazG family protein
CD178_RS02885	COG0483	inositol monophosphate 1-phosphatase activity
CD178_RS02890	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CD178_RS02895	COG1923	regulation of RNA biosynthetic process
CD178_RS02900	COG2204	response regulator
CD178_RS02915	COG3852	Histidine kinase
CD178_RS02930	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CD178_RS02930	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CD178_RS02945	COG0564	pseudouridine synthase activity
CD178_RS02950	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CD178_RS02955	COG1696	Membrane protein involved in D-alanine export
CD178_RS02960	COG2081	HI0933 family
CD178_RS02970	COG0850	regulation of cytokinetic process
CD178_RS02980	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CD178_RS02985	COG1802	Transcriptional regulator
CD178_RS02995	COG1012	belongs to the aldehyde dehydrogenase family
CD178_RS03000	COG1072	(Pantothenic acid kinase))
CD178_RS03020	COG0405	Gamma-glutamyltransferase
CD178_RS03030	COG0156	8-amino-7-oxononanoate synthase activity
CD178_RS03050	COG0126	phosphoglycerate kinase activity
CD178_RS03060	COG0552	protein localization to endoplasmic reticulum
CD178_RS03065	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CD178_RS03070	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CD178_RS03075	COG0346	lactoylglutathione lyase activity
CD178_RS03095	COG1120	ATPase activity
CD178_RS03100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CD178_RS03110	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CD178_RS03110	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CD178_RS03115	COG0509	glycine decarboxylation via glycine cleavage system
CD178_RS03120	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CD178_RS03130	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CD178_RS03135	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CD178_RS03145	COG0629	single-stranded DNA binding
CD178_RS03150	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CD178_RS03155	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CD178_RS03170	COG0129	dihydroxy-acid dehydratase activity
CD178_RS03175	COG0800	Aldolase
CD178_RS03185	COG3416	Protein conserved in bacteria
CD178_RS03190	COG0752	glycyl-tRNA synthetase alpha subunit
CD178_RS03205	COG0772	Belongs to the SEDS family
CD178_RS03210	COG0768	penicillin binding
CD178_RS03235	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CD178_RS03245	COG0860	N-Acetylmuramoyl-L-alanine amidase
CD178_RS03260	COG1530	ribonuclease E activity
CD178_RS03280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CD178_RS03285	COG0347	Belongs to the P(II) protein family
CD178_RS03305	COG4974	Belongs to the 'phage' integrase family
CD178_RS03315	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CD178_RS03320	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CD178_RS03330	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CD178_RS03350	COG0523	cobalamin synthesis protein
CD178_RS03365	COG0482	sulfurtransferase activity
CD178_RS03385	COG2945	thiolester hydrolase activity
CD178_RS03390	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CD178_RS03405	COG2309	aminopeptidase activity
CD178_RS03425	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CD178_RS03435	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CD178_RS03440	COG3158	transport of potassium into the cell
CD178_RS03445	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CD178_RS03465	COG1472	Belongs to the glycosyl hydrolase 3 family
CD178_RS03475	COG0495	leucyl-tRNA aminoacylation
CD178_RS03505	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CD178_RS03510	COG0662	Cupin 2, conserved barrel domain protein
CD178_RS03510	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CD178_RS03550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CD178_RS03610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CD178_RS03630	COG0251	oxidation-reduction process
CD178_RS03640	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CD178_RS03645	COG0799	negative regulation of ribosome biogenesis
CD178_RS03650	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CD178_RS03655	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CD178_RS03660	COG0012	GTP binding
CD178_RS03665	COG0193	aminoacyl-tRNA hydrolase activity
CD178_RS03670	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CD178_RS03675	COG0406	alpha-ribazole phosphatase activity
CD178_RS03680	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CD178_RS03690	COG1496	oxidoreductase activity
CD178_RS03700	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CD178_RS03740	COG2308	Evidence 4 Homologs of previously reported genes of
CD178_RS03760	COG0247	lactate metabolic process
CD178_RS03775	COG0776	regulation of translation
CD178_RS03790	COG5487	UPF0391 membrane protein
CD178_RS03835	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CD178_RS03880	COG0481	GTPase activity
CD178_RS03890	COG4221	oxidoreductase activity
CD178_RS03915	COG0129	dihydroxy-acid dehydratase activity
CD178_RS03950	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CD178_RS03970	COG0436	Aminotransferase
CD178_RS03985	COG3321	synthase
CD178_RS03985	COG0604	alcohol dehydrogenase
CD178_RS03985	COG1028	Short-chain dehydrogenase reductase Sdr
CD178_RS03990	COG0596	Alpha beta hydrolase
CD178_RS04000	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CD178_RS04005	COG1692	metallophosphoesterase
CD178_RS04010	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CD178_RS04035	COG0352	thiamine-phosphate diphosphorylase activity
CD178_RS04040	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CD178_RS04050	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CD178_RS04055	COG0483	inositol monophosphate 1-phosphatase activity
CD178_RS04080	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CD178_RS04085	COG0583	DNA-binding transcription factor activity
CD178_RS04095	COG1902	pentaerythritol trinitrate reductase activity
CD178_RS04100	COG3001	Fructosamine kinase
CD178_RS04105	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CD178_RS04110	COG3265	gluconokinase activity
CD178_RS04115	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CD178_RS04120	COG0363	glucosamine-6-phosphate deaminase activity
CD178_RS04130	COG0561	phosphatase activity
CD178_RS04135	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CD178_RS04140	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CD178_RS04145	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CD178_RS04165	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CD178_RS04175	COG2814	Major facilitator Superfamily
CD178_RS04185	COG2943	transferase activity, transferring hexosyl groups
CD178_RS04190	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CD178_RS04205	COG0246	Mannitol dehydrogenase
CD178_RS04215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CD178_RS04230	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CD178_RS04240	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CD178_RS04245	COG0343	queuine tRNA-ribosyltransferase activity
CD178_RS04250	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CD178_RS04260	COG1881	PFAM PEBP family protein
CD178_RS04290	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
CD178_RS04295	COG2853	Lipoprotein
CD178_RS04310	COG0488	(ABC) transporter
CD178_RS04320	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CD178_RS04360	COG0646	methionine synthase
CD178_RS04360	COG1410	methionine synthase
CD178_RS04375	COG0438	transferase activity, transferring glycosyl groups
CD178_RS04440	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CD178_RS04440	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CD178_RS04460	COG3436	PFAM IS66 Orf2 family protein
CD178_RS04465	COG4372	Transposase
CD178_RS04510	COG0140	phosphoribosyl-ATP diphosphatase activity
CD178_RS04520	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CD178_RS04525	COG1028	Short-chain dehydrogenase reductase Sdr
CD178_RS04530	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CD178_RS04550	COG1570	exodeoxyribonuclease VII activity
CD178_RS04560	COG2814	Major facilitator Superfamily
CD178_RS04595	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CD178_RS04605	COG4974	Belongs to the 'phage' integrase family
CD178_RS04610	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CD178_RS04620	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CD178_RS04625	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CD178_RS04630	COG0778	Nitroreductase
CD178_RS04640	COG0604	alcohol dehydrogenase
CD178_RS04690	COG2099	Precorrin-6x reductase
CD178_RS04710	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CD178_RS04715	COG1797	cobyrinic acid a,c-diamide synthase activity
CD178_RS04725	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CD178_RS04725	COG1918	ferrous iron import across plasma membrane
CD178_RS04735	COG2200	EAL domain
CD178_RS04735	COG2202	Pas domain
CD178_RS04735	COG2199	diguanylate cyclase activity
CD178_RS04740	COG5001	Diguanylate cyclase
CD178_RS04740	COG1716	ATPase activity
CD178_RS04745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CD178_RS04750	COG0508	dehydrogenase complex catalyzes the overall conversion of
CD178_RS04760	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CD178_RS04765	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CD178_RS04785	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CD178_RS04790	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CD178_RS04805	COG1053	succinate dehydrogenase
CD178_RS04810	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CD178_RS04820	COG1396	sequence-specific DNA binding
CD178_RS04825	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CD178_RS04850	COG0456	acetyltransferase
CD178_RS04860	COG0778	Nitroreductase
CD178_RS04900	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CD178_RS04905	COG0667	Aldo Keto reductase
CD178_RS04910	COG1420	regulation of RNA biosynthetic process
CD178_RS04915	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CD178_RS04920	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CD178_RS04930	COG1185	polyribonucleotide nucleotidyltransferase activity
CD178_RS04935	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CD178_RS04940	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CD178_RS04950	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CD178_RS04955	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CD178_RS04955	COG5373	membrane
CD178_RS04970	COG0779	Required for maturation of 30S ribosomal subunits
CD178_RS04980	COG0542	response to heat
CD178_RS04990	COG0583	DNA-binding transcription factor activity
CD178_RS05000	COG4133	protoheme IX ABC transporter activity
CD178_RS05005	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CD178_RS05015	COG0019	diaminopimelate decarboxylase activity
CD178_RS05020	COG1295	ribonuclease BN
CD178_RS05025	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CD178_RS05035	COG0511	ligase activity, forming carbon-carbon bonds
CD178_RS05040	COG0439	Biotin carboxylase
CD178_RS05045	COG1289	transmembrane transporter activity
CD178_RS05050	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CD178_RS05055	COG2814	Major facilitator Superfamily
CD178_RS05065	COG1612	heme a metabolic process
CD178_RS05080	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CD178_RS05100	COG0135	phosphoribosylanthranilate isomerase activity
CD178_RS05105	COG0284	orotidine-5'-phosphate decarboxylase activity
CD178_RS05125	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CD178_RS05130	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CD178_RS05135	COG0312	modulator of DNA gyrase
CD178_RS05205	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CD178_RS05210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CD178_RS05215	COG0590	tRNA wobble adenosine to inosine editing
CD178_RS05230	COG0564	pseudouridine synthase activity
CD178_RS05235	COG1674	ftsk spoiiie
CD178_RS05240	COG0742	ribosomal rna small subunit methyltransferase
CD178_RS05245	COG1187	pseudouridine synthase activity
CD178_RS05250	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CD178_RS05270	COG0357	Ribosomal RNA small subunit methyltransferase G
CD178_RS05275	COG0445	tRNA wobble uridine modification
CD178_RS05280	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CD178_RS05295	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CD178_RS05305	COG0133	tryptophan synthase activity
CD178_RS05310	COG0159	tryptophan synthase activity
CD178_RS05315	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CD178_RS05320	COG0285	dihydrofolate synthase activity
CD178_RS05325	COG2814	Major facilitator Superfamily
CD178_RS05335	COG0735	belongs to the Fur family
CD178_RS05345	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CD178_RS05350	COG1024	Enoyl-CoA hydratase
CD178_RS05355	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CD178_RS05360	COG2814	Major facilitator Superfamily
CD178_RS05375	COG1028	Short-chain dehydrogenase reductase Sdr
CD178_RS05380	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CD178_RS05385	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CD178_RS05390	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CD178_RS05395	COG0484	heat shock protein binding
CD178_RS05400	COG0443	Heat shock 70 kDa protein
CD178_RS05405	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CD178_RS05410	COG0745	RESPONSE REGULATOR receiver
CD178_RS05415	COG2205	protein histidine kinase activity
CD178_RS05420	COG0535	radical SAM domain protein
CD178_RS05430	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
CD178_RS05435	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CD178_RS05445	COG0628	permease
CD178_RS05450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CD178_RS05460	COG3047	cAMP biosynthetic process
CD178_RS05465	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CD178_RS05480	COG2086	electron transfer activity
CD178_RS05500	COG1091	dTDP-4-dehydrorhamnose reductase activity
CD178_RS05515	COG0424	maF-like protein
CD178_RS05520	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CD178_RS05525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CD178_RS05530	COG1981	membrane
CD178_RS05555	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CD178_RS05575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CD178_RS05575	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CD178_RS05590	COG0138	bifunctional purine biosynthesis protein purh
CD178_RS05605	COG0356	it plays a direct role in the translocation of protons across the membrane
CD178_RS05610	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CD178_RS05615	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CD178_RS05620	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CD178_RS05625	COG1215	transferase activity, transferring glycosyl groups
CD178_RS05630	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CD178_RS05635	COG0673	inositol 2-dehydrogenase activity
CD178_RS05655	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CD178_RS05675	COG0300	oxidoreductase activity
CD178_RS05680	COG0194	GDP metabolic process
CD178_RS05685	COG2814	Major facilitator Superfamily
CD178_RS05705	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CD178_RS05710	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CD178_RS05720	COG1657	PFAM Prenyltransferase squalene oxidase
CD178_RS05725	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CD178_RS05730	COG1562	ergosterol biosynthetic process
CD178_RS05735	COG1562	ergosterol biosynthetic process
CD178_RS05740	COG1215	transferase activity, transferring glycosyl groups
CD178_RS05745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CD178_RS05755	COG0287	Prephenate dehydrogenase
CD178_RS05760	COG0469	pyruvate kinase activity
CD178_RS05775	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CD178_RS05800	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CD178_RS05815	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CD178_RS05815	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CD178_RS05820	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CD178_RS05850	COG1127	ABC transporter
CD178_RS05855	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CD178_RS05885	COG1566	PFAM secretion protein HlyD family protein
CD178_RS05910	COG3842	ATPase activity
CD178_RS05925	COG2983	Belongs to the UPF0260 family
CD178_RS05940	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CD178_RS05950	COG3830	Belongs to the UPF0237 family
CD178_RS05950	COG0560	Phosphoserine phosphatase
CD178_RS05955	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CD178_RS05960	COG0028	Belongs to the TPP enzyme family
CD178_RS05970	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CD178_RS05980	COG0583	DNA-binding transcription factor activity
CD178_RS05985	COG0667	Aldo Keto reductase
CD178_RS05990	COG0542	response to heat
CD178_RS06025	COG5001	Diguanylate cyclase
CD178_RS06030	COG3025	triphosphatase activity
CD178_RS06055	COG1999	signal sequence binding
CD178_RS06060	COG0747	negative chemotaxis
CD178_RS06075	COG0803	Belongs to the bacterial solute-binding protein 9 family
CD178_RS06085	COG1120	ATPase activity
CD178_RS06090	COG1280	lysine exporter protein (LysE YggA)
CD178_RS06095	COG0114	fumarate hydratase activity
CD178_RS06110	COG1028	Short-chain dehydrogenase reductase Sdr
CD178_RS06130	COG2999	glutathione oxidoreductase activity
CD178_RS06140	COG0723	plastoquinol--plastocyanin reductase activity
CD178_RS06165	COG2948	multi-organism process
CD178_RS06180	COG0671	phosphoesterase, PA-phosphatase related
CD178_RS06185	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CD178_RS06200	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CD178_RS06215	COG0745	RESPONSE REGULATOR receiver
CD178_RS06220	COG0242	peptide deformylase activity
CD178_RS06235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CD178_RS06245	COG2199	diguanylate cyclase activity
CD178_RS06245	COG2200	EAL domain
CD178_RS06245	COG2202	Pas domain
CD178_RS06260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CD178_RS06265	COG0251	oxidation-reduction process
CD178_RS06270	COG1028	Short-chain dehydrogenase reductase Sdr
CD178_RS06295	COG0778	Nitroreductase
CD178_RS06300	COG0586	Pfam SNARE associated Golgi protein
CD178_RS06310	COG0538	isocitrate dehydrogenase activity
CD178_RS06315	COG2194	sulfuric ester hydrolase activity
CD178_RS06395	COG2610	gluconate transmembrane transporter activity
CD178_RS06415	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CD178_RS06465	COG1648	precorrin-2 dehydrogenase activity
CD178_RS06465	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CD178_RS06475	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CD178_RS06480	COG2835	tetraacyldisaccharide 4'-kinase activity
CD178_RS06485	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CD178_RS06515	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CD178_RS06525	COG0656	L-ascorbic acid biosynthetic process
CD178_RS06560	COG2199	diguanylate cyclase activity
CD178_RS06560	COG2200	EAL domain
CD178_RS06560	COG2202	Pas domain
CD178_RS06575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CD178_RS06610	COG0004	ammonium transporteR
CD178_RS06615	COG0347	Belongs to the P(II) protein family
CD178_RS06650	COG1289	transmembrane transporter activity
CD178_RS06660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CD178_RS06665	COG0842	Transport permease protein
CD178_RS06665	COG1129	ABC transporter
CD178_RS06670	COG0842	Transport permease protein
CD178_RS06680	COG2610	gluconate transmembrane transporter activity
CD178_RS06690	COG2995	paraquat-inducible protein a
CD178_RS06695	COG3008	intermembrane lipid transfer
CD178_RS06710	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CD178_RS06730	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CD178_RS06735	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CD178_RS06740	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CD178_RS06745	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CD178_RS06750	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CD178_RS06755	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CD178_RS06760	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CD178_RS06775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CD178_RS06780	COG1217	gtp-binding protein TYPA
CD178_RS06790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CD178_RS06795	COG0492	ferredoxin-NADP+ reductase activity
CD178_RS06805	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CD178_RS06815	COG1074	ATP-dependent DNA helicase activity
CD178_RS06820	COG3118	belongs to the thioredoxin family
CD178_RS06825	COG3394	polysaccharide catabolic process
CD178_RS06845	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CD178_RS06850	COG0535	radical SAM domain protein
CD178_RS06855	COG1253	flavin adenine dinucleotide binding
CD178_RS06865	COG1573	uracil-dna glycosylase
CD178_RS06875	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CD178_RS06915	COG0667	Aldo Keto reductase
CD178_RS06925	COG0025	NhaP-type Na H and K H
CD178_RS06935	COG0484	heat shock protein binding
CD178_RS06960	COG0277	FAD linked oxidase domain protein
CD178_RS06965	COG3961	Belongs to the TPP enzyme family
CD178_RS06990	COG0521	Mo-molybdopterin cofactor biosynthetic process
CD178_RS07000	COG0302	gtp cyclohydrolase
CD178_RS07005	COG2967	ApaG domain
CD178_RS07035	COG1127	ABC transporter
CD178_RS07040	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CD178_RS07055	COG0668	transmembrane transport
CD178_RS07060	COG1714	RDD family
CD178_RS07065	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CD178_RS07070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CD178_RS07075	COG0653	protein targeting
CD178_RS07080	COG0217	transcriptional regulatory protein
CD178_RS07085	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CD178_RS07090	COG0632	four-way junction helicase activity
CD178_RS07095	COG2255	four-way junction helicase activity
CD178_RS07100	COG0824	Thioesterase
CD178_RS07110	COG0848	biopolymer transport protein
CD178_RS07120	COG0823	Involved in the tonB-independent uptake of proteins
CD178_RS07125	COG2885	chlorophyll binding
CD178_RS07135	COG0037	tRNA processing
CD178_RS07145	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CD178_RS07150	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CD178_RS07155	COG0352	thiamine-phosphate diphosphorylase activity
CD178_RS07155	COG0351	phosphomethylpyrimidine kinase
CD178_RS07185	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CD178_RS07205	COG0450	alkyl hydroperoxide reductase
CD178_RS07215	COG1321	iron dependent repressor
CD178_RS07225	COG1132	(ABC) transporter
CD178_RS07240	COG2176	DNA-directed DNA polymerase activity
CD178_RS07245	COG0010	Belongs to the arginase family
CD178_RS07255	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CD178_RS07260	COG2368	4-hydroxyphenylacetate
CD178_RS07310	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CD178_RS07320	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CD178_RS07340	COG3971	2-oxopent-4-enoate hydratase activity
CD178_RS07355	COG1917	Cupin 2, conserved barrel domain protein
CD178_RS07370	COG0697	spore germination
CD178_RS07375	COG2211	Major facilitator Superfamily
CD178_RS07380	COG3408	Glycogen debranching enzyme
CD178_RS07380	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
CD178_RS07395	COG1522	sequence-specific DNA binding
CD178_RS07405	COG3842	ATPase activity
CD178_RS07410	COG0395	ABC-type sugar transport system, permease component
CD178_RS07415	COG1176	ABC-type spermidine putrescine transport system, permease component I
CD178_RS07430	COG1012	belongs to the aldehyde dehydrogenase family
CD178_RS07435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CD178_RS07450	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CD178_RS07455	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CD178_RS07470	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CD178_RS07470	COG0446	pyridine nucleotide-disulphide oxidoreductase
CD178_RS07480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CD178_RS07485	COG0583	DNA-binding transcription factor activity
CD178_RS07495	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CD178_RS07500	COG2218	PFAM glutamate synthase alpha subunit domain protein
CD178_RS07505	COG0069	glutamate synthase activity
CD178_RS07520	COG2249	NAD(P)H dehydrogenase (quinone) activity
CD178_RS07525	COG1538	Outer membrane efflux protein
CD178_RS07540	COG3473	Maleate cis-trans isomerase
CD178_RS07545	COG2271	Major facilitator Superfamily
CD178_RS07550	COG1846	Transcriptional regulator
CD178_RS07565	COG1289	transmembrane transporter activity
CD178_RS07570	COG0697	spore germination
CD178_RS07580	COG1309	transcriptional regulator
CD178_RS07585	COG1252	NADH dehydrogenase
CD178_RS07590	COG1012	belongs to the aldehyde dehydrogenase family
CD178_RS07595	COG2814	Major facilitator Superfamily
CD178_RS07635	COG0436	Aminotransferase
CD178_RS07645	COG0740	serine-type endopeptidase activity
CD178_RS07670	COG2199	diguanylate cyclase activity
CD178_RS07670	COG2202	Pas domain
CD178_RS07670	COG2200	EAL domain
CD178_RS07675	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CD178_RS07685	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CD178_RS07690	COG1530	ribonuclease E activity
CD178_RS07695	COG0424	maF-like protein
CD178_RS07700	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CD178_RS07705	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CD178_RS07710	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CD178_RS07715	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CD178_RS07720	COG0717	Belongs to the dCTP deaminase family
CD178_RS07735	COG0438	transferase activity, transferring glycosyl groups
CD178_RS07750	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CD178_RS07790	COG4232	protein-disulfide reductase activity
CD178_RS07810	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CD178_RS07815	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CD178_RS07830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CD178_RS07835	COG0235	Class ii aldolase
CD178_RS07840	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CD178_RS07845	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
CD178_RS07850	COG0196	riboflavin kinase activity
CD178_RS07855	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CD178_RS07860	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CD178_RS07870	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CD178_RS07880	COG0187	DNA topoisomerase II activity
CD178_RS07895	COG1959	2 iron, 2 sulfur cluster binding
CD178_RS07900	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CD178_RS07905	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CD178_RS07905	COG2885	chlorophyll binding
CD178_RS07915	COG0793	Belongs to the peptidase S41A family
CD178_RS07920	COG0557	exoribonuclease II activity
CD178_RS07925	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CD178_RS07930	COG0758	DNA mediated transformation
CD178_RS07935	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CD178_RS07940	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CD178_RS07945	COG0540	Belongs to the ATCase OTCase family
CD178_RS07950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CD178_RS07960	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CD178_RS07965	COG5265	(ABC) transporter
CD178_RS07975	COG0140	phosphoribosyl-ATP diphosphatase activity
CD178_RS07980	COG0107	imidazoleglycerol-phosphate synthase activity
CD178_RS07985	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CD178_RS07990	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CD178_RS08000	COG0131	Imidazoleglycerol-phosphate dehydratase
CD178_RS08005	COG0778	Nitroreductase
CD178_RS08050	COG4372	Transposase
CD178_RS08075	COG2357	RelA SpoT domain protein
CD178_RS08110	COG0741	lytic transglycosylase activity
CD178_RS08150	COG0517	IMP dehydrogenase activity
CD178_RS08225	COG0583	DNA-binding transcription factor activity
CD178_RS08230	COG3048	D-serine ammonia-lyase activity
CD178_RS08245	COG2985	domain, Protein
CD178_RS08255	COG0252	asparaginase activity
CD178_RS08280	COG2211	Major facilitator Superfamily
CD178_RS08285	COG1012	belongs to the aldehyde dehydrogenase family
CD178_RS08305	COG4650	regulator
CD178_RS08325	COG2837	iron assimilation
CD178_RS08330	COG0583	DNA-binding transcription factor activity
CD178_RS08340	COG0583	DNA-binding transcription factor activity
CD178_RS08345	COG1473	amidohydrolase
CD178_RS08355	COG2271	Major facilitator Superfamily
CD178_RS08360	COG2843	Capsule synthesis protein
CD178_RS08375	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CD178_RS08385	COG2132	Multicopper oxidase
CD178_RS08410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CD178_RS08415	COG1937	Protein conserved in bacteria
CD178_RS08445	COG0446	pyridine nucleotide-disulphide oxidoreductase
CD178_RS08445	COG1902	pentaerythritol trinitrate reductase activity
CD178_RS08465	COG0573	inorganic phosphate transmembrane transporter activity
CD178_RS08475	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CD178_RS08500	COG1012	belongs to the aldehyde dehydrogenase family
CD178_RS08520	COG0574	Belongs to the PEP-utilizing enzyme family
CD178_RS08520	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CD178_RS08525	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CD178_RS08530	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CD178_RS08535	COG3961	Belongs to the TPP enzyme family
CD178_RS08540	COG2814	Major facilitator Superfamily
CD178_RS08550	COG0252	asparaginase activity
CD178_RS08560	COG1113	amino acid transport
CD178_RS08575	COG0406	alpha-ribazole phosphatase activity
CD178_RS08580	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CD178_RS08585	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CD178_RS08600	COG1492	cobalamin metabolic process
CD178_RS08605	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CD178_RS08635	COG0167	dihydroorotate dehydrogenase activity
CD178_RS08645	COG1678	Uncharacterized ACR, COG1678
CD178_RS08650	COG4221	oxidoreductase activity
CD178_RS08655	COG2326	polyphosphate kinase activity
CD178_RS08665	COG1742	UPF0060 membrane protein
CD178_RS08680	COG1686	Belongs to the peptidase S11 family
CD178_RS08685	COG0024	Methionine aminopeptidase
CD178_RS08705	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CD178_RS08710	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CD178_RS08715	COG1028	Short-chain dehydrogenase reductase Sdr
CD178_RS08720	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CD178_RS08730	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CD178_RS08735	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CD178_RS08740	COG0539	negative regulation of cytoplasmic translation
CD178_RS08760	COG5508	conserved small protein
CD178_RS08770	COG3088	subunit of a heme lyase
CD178_RS08775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CD178_RS08780	COG1138	Cytochrome C-type biogenesis protein
CD178_RS08785	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CD178_RS08795	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CD178_RS08825	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CD178_RS08845	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CD178_RS08860	COG0477	Major facilitator Superfamily
CD178_RS08865	COG1301	dicarboxylic acid transport
CD178_RS08900	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CD178_RS08905	COG0081	regulation of translation
CD178_RS08910	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CD178_RS08915	COG0222	ribosome binding
CD178_RS08920	COG0085	RNA polymerase activity
CD178_RS08925	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CD178_RS08930	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CD178_RS08935	COG0049	tRNA binding
CD178_RS08940	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CD178_RS08945	COG0051	transcription antitermination factor activity, RNA binding
CD178_RS08950	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CD178_RS08955	COG0088	Forms part of the polypeptide exit tunnel
CD178_RS08960	COG0089	rRNA binding
CD178_RS08965	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CD178_RS08970	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CD178_RS08975	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CD178_RS08980	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CD178_RS08985	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CD178_RS08990	COG0255	Belongs to the universal ribosomal protein uL29 family
CD178_RS08995	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CD178_RS09000	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CD178_RS09005	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CD178_RS09010	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CD178_RS09015	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CD178_RS09020	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CD178_RS09025	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CD178_RS09030	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CD178_RS09035	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CD178_RS09040	COG1841	ribosomal large subunit assembly
CD178_RS09045	COG0200	Binds to the 23S rRNA
CD178_RS09050	COG0201	protein transport
CD178_RS09055	COG0563	adenylate kinase activity
CD178_RS09060	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CD178_RS09065	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CD178_RS09070	COG0202	RNA polymerase activity
CD178_RS09075	COG0203	ribosomal protein L17
CD178_RS09090	COG1116	anion transmembrane transporter activity
CD178_RS09115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CD178_RS09125	COG0477	Major facilitator Superfamily
CD178_RS09140	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CD178_RS09145	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CD178_RS09175	COG0714	Associated with various cellular activities
CD178_RS09185	COG0617	tRNA 3'-terminal CCA addition
CD178_RS09190	COG1132	(ABC) transporter
CD178_RS09195	COG1566	PFAM secretion protein HlyD family protein
CD178_RS09200	COG2814	Major facilitator Superfamily
CD178_RS09205	COG0494	nUDIX hydrolase
CD178_RS09210	COG1051	belongs to the nudix hydrolase family
CD178_RS09215	COG0793	Belongs to the peptidase S41A family
CD178_RS09225	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CD178_RS09230	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CD178_RS09235	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CD178_RS09245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CD178_RS09250	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CD178_RS09255	COG0505	Belongs to the CarA family
CD178_RS09265	COG0358	DNA primase activity
CD178_RS09270	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CD178_RS09280	COG0360	Binds together with S18 to 16S ribosomal RNA
CD178_RS09285	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CD178_RS09290	COG0359	binds to the 23S rRNA
CD178_RS09295	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CD178_RS09300	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CD178_RS09310	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CD178_RS09325	COG0277	FAD linked oxidase domain protein
CD178_RS09335	COG0009	L-threonylcarbamoyladenylate synthase
CD178_RS09345	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CD178_RS09355	COG0656	L-ascorbic acid biosynthetic process
CD178_RS09380	COG0649	NAD binding
CD178_RS09385	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CD178_RS09395	COG0688	phosphatidylethanolamine metabolic process
CD178_RS09405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CD178_RS09410	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
CD178_RS09430	COG2884	Cell division ATP-binding protein ftsE
CD178_RS09480	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CD178_RS09485	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CD178_RS09500	COG1032	radical SAM domain protein
CD178_RS09515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CD178_RS09540	COG3265	gluconokinase activity
CD178_RS09545	COG2096	Adenosyltransferase
CD178_RS09560	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CD178_RS09575	COG1297	OPT oligopeptide transporter protein
CD178_RS09585	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CD178_RS09590	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CD178_RS09595	COG0328	RNA-DNA hybrid ribonuclease activity
CD178_RS09600	COG1116	anion transmembrane transporter activity
CD178_RS09605	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CD178_RS09615	COG0573	inorganic phosphate transmembrane transporter activity
CD178_RS09620	COG0581	inorganic phosphate transmembrane transporter activity
CD178_RS09625	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CD178_RS09640	COG0228	four-way junction DNA binding
CD178_RS09645	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CD178_RS09650	COG0336	Belongs to the RNA methyltransferase TrmD family
CD178_RS09655	COG0335	large ribosomal subunit rRNA binding
CD178_RS09660	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CD178_RS09665	COG0066	3-isopropylmalate dehydratase activity
CD178_RS09670	COG0473	3-isopropylmalate dehydrogenase activity
CD178_RS09675	COG0745	RESPONSE REGULATOR receiver
CD178_RS09690	COG0242	peptide deformylase activity
CD178_RS09695	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CD178_RS09715	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CD178_RS09720	COG0416	fatty acid biosynthetic process
CD178_RS09725	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CD178_RS09730	COG0776	regulation of translation
CD178_RS09745	COG0628	permease
CD178_RS09760	COG5265	(ABC) transporter
CD178_RS09770	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CD178_RS09775	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CD178_RS09785	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CD178_RS09790	COG2733	membrane
CD178_RS09800	COG0719	Fe-S assembly protein
CD178_RS09805	COG0396	ATPase activity
CD178_RS09810	COG0719	Fe-S assembly protein
CD178_RS09815	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CD178_RS09825	COG2151	metal-sulfur cluster biosynthetic enzyme
CD178_RS09840	COG0513	Belongs to the DEAD box helicase family
CD178_RS09860	COG0544	peptidyl-prolyl cis-trans isomerase activity
CD178_RS09865	COG0740	serine-type endopeptidase activity
CD178_RS09870	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CD178_RS09880	COG0776	regulation of translation
CD178_RS09895	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CD178_RS09900	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CD178_RS09905	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CD178_RS09910	COG0649	NAD binding
CD178_RS09915	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CD178_RS09925	COG1034	ATP synthesis coupled electron transport
CD178_RS09930	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CD178_RS09935	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CD178_RS09945	COG0713	ATP synthesis coupled electron transport
CD178_RS09955	COG1007	ATP synthesis coupled electron transport
CD178_RS09970	COG0442	prolyl-tRNA aminoacylation
CD178_RS09980	COG1136	(ABC) transporter
CD178_RS09990	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CD178_RS09995	COG2813	Specifically methylates the guanine in position
CD178_RS09995	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CD178_RS10000	COG0778	Nitroreductase
CD178_RS10005	COG0513	Belongs to the DEAD box helicase family
CD178_RS10060	COG1396	sequence-specific DNA binding
CD178_RS10090	COG0305	Participates in initiation and elongation during chromosome replication
CD178_RS10145	COG0741	lytic transglycosylase activity
CD178_RS10160	COG4372	Transposase
CD178_RS10165	COG3436	PFAM IS66 Orf2 family protein
CD178_RS10225	COG3093	addiction module antidote protein HigA
CD178_RS10295	COG2244	polysaccharide biosynthetic process
CD178_RS10305	COG1671	Belongs to the UPF0178 family
CD178_RS10330	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CD178_RS10370	COG1079	Belongs to the binding-protein-dependent transport system permease family
CD178_RS10375	COG4603	Belongs to the binding-protein-dependent transport system permease family
CD178_RS10380	COG3845	ABC transporter
CD178_RS10385	COG1744	ABC transporter substrate-binding protein PnrA-like
CD178_RS10390	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CD178_RS10400	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CD178_RS10405	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CD178_RS10415	COG0849	cell division
CD178_RS10420	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CD178_RS10425	COG1181	Belongs to the D-alanine--D-alanine ligase family
CD178_RS10430	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CD178_RS10435	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CD178_RS10440	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CD178_RS10450	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CD178_RS10455	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CD178_RS10460	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CD178_RS10465	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CD178_RS10480	COG0275	rRNA processing
CD178_RS10485	COG2001	Belongs to the MraZ family
CD178_RS10495	COG0657	acetylesterase activity
CD178_RS10505	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CD178_RS10510	COG3750	Belongs to the UPF0335 family
CD178_RS10520	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CD178_RS10525	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CD178_RS10530	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CD178_RS10535	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CD178_RS10545	COG0402	S-adenosylhomocysteine deaminase activity
CD178_RS10550	COG1289	transmembrane transporter activity
CD178_RS10555	COG1573	uracil-dna glycosylase
CD178_RS10570	COG4957	zinc ion binding
CD178_RS10575	COG0616	signal peptide processing
CD178_RS10580	COG0776	regulation of translation
CD178_RS10585	COG0583	DNA-binding transcription factor activity
CD178_RS10590	COG0492	ferredoxin-NADP+ reductase activity
CD178_RS10595	COG1522	sequence-specific DNA binding
CD178_RS10620	COG0519	Catalyzes the synthesis of GMP from XMP
CD178_RS10620	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CD178_RS10640	COG5001	Diguanylate cyclase
CD178_RS10640	COG3300	MHYT domain
CD178_RS10655	COG0438	transferase activity, transferring glycosyl groups
CD178_RS10660	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CD178_RS10665	COG0504	CTP synthase activity
CD178_RS10670	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CD178_RS10675	COG0149	triose-phosphate isomerase activity
CD178_RS10685	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CD178_RS10695	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CD178_RS10700	COG0134	indole-3-glycerol-phosphate synthase activity
CD178_RS10705	COG0315	cyclic pyranopterin monophosphate synthase activity
CD178_RS10710	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CD178_RS10715	COG0022	dehydrogenase e1 component
CD178_RS10715	COG0508	dehydrogenase complex catalyzes the overall conversion of
CD178_RS10720	COG0508	dehydrogenase complex catalyzes the overall conversion of
CD178_RS10725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CD178_RS10730	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CD178_RS10735	COG2867	negative regulation of translational initiation
CD178_RS10745	COG1546	Belongs to the CinA family
CD178_RS10745	COG1058	Belongs to the CinA family
CD178_RS10750	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CD178_RS10755	COG0741	lytic transglycosylase activity
CD178_RS10760	COG0861	Integral membrane protein TerC family
CD178_RS10765	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CD178_RS10775	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CD178_RS10780	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CD178_RS10790	COG0047	phosphoribosylformylglycinamidine synthase activity
CD178_RS10795	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CD178_RS10800	COG0271	Belongs to the BolA IbaG family
CD178_RS10805	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CD178_RS10815	COG0792	nuclease activity
CD178_RS10820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CD178_RS10830	COG0628	permease
CD178_RS10835	COG2897	thiosulfate sulfurtransferase activity
CD178_RS10840	COG0626	cystathionine gamma-synthase activity
CD178_RS10870	COG2814	Major facilitator Superfamily
CD178_RS10875	COG1272	protein, Hemolysin III
CD178_RS10880	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CD178_RS10885	COG1522	sequence-specific DNA binding
CD178_RS10915	COG0583	DNA-binding transcription factor activity
CD178_RS10930	COG1968	undecaprenyl-diphosphatase activity
CD178_RS10945	COG0586	Pfam SNARE associated Golgi protein
CD178_RS10955	COG1686	Belongs to the peptidase S11 family
CD178_RS10960	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CD178_RS10975	COG0084	hydrolase, TatD family'
CD178_RS10980	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CD178_RS10980	COG0321	lipoyl(octanoyl) transferase activity
CD178_RS10990	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CD178_RS10990	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CD178_RS11005	COG0745	RESPONSE REGULATOR receiver
CD178_RS11010	COG0708	Exodeoxyribonuclease III
CD178_RS11015	COG0322	excinuclease ABC activity
CD178_RS11030	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CD178_RS11035	COG0314	molybdopterin synthase activity
CD178_RS11040	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CD178_RS11040	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CD178_RS11045	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CD178_RS11050	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CD178_RS11055	COG0142	geranyltranstransferase activity
CD178_RS11060	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CD178_RS11065	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CD178_RS11085	COG0287	Prephenate dehydrogenase
CD178_RS11085	COG1605	Chorismate mutase
CD178_RS11100	COG1196	nuclear chromosome segregation
CD178_RS11115	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CD178_RS11120	COG1702	phosphate starvation-inducible protein PhoH
CD178_RS11125	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CD178_RS11130	COG0729	surface antigen
CD178_RS11140	COG2814	Major facilitator Superfamily
CD178_RS11145	COG2824	Alkylphosphonate utilization operon protein PhnA
CD178_RS11155	COG3781	membrane
CD178_RS11160	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CD178_RS11165	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CD178_RS11170	COG0432	Pfam Uncharacterised protein family UPF0047
CD178_RS11175	COG0180	Tryptophanyl-tRNA synthetase
CD178_RS11185	COG0545	Peptidyl-prolyl cis-trans isomerase
CD178_RS11190	COG0137	argininosuccinate synthase activity
CD178_RS11195	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CD178_RS11200	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CD178_RS11205	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CD178_RS11215	COG1722	exodeoxyribonuclease VII activity
CD178_RS11220	COG0425	Belongs to the sulfur carrier protein TusA family
CD178_RS11225	COG1940	carbohydrate kinase activity
CD178_RS11230	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CD178_RS11255	COG1741	Belongs to the pirin family
CD178_RS11260	COG0583	DNA-binding transcription factor activity
CD178_RS11265	COG0655	NAD(P)H dehydrogenase (quinone) activity
CD178_RS11275	COG1028	Short-chain dehydrogenase reductase Sdr
CD178_RS11280	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CD178_RS11285	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CD178_RS11290	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CD178_RS11295	COG0072	phenylalanine-tRNA ligase activity
CD178_RS11295	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CD178_RS11305	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CD178_RS11315	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CD178_RS11340	COG1160	GTP binding
CD178_RS11345	COG1335	isochorismatase
CD178_RS11385	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CD178_RS11405	COG1663	tetraacyldisaccharide 4'-kinase activity
CD178_RS11410	COG1519	Transferase
CD178_RS11420	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CD178_RS11435	COG0175	sulfate reduction
CD178_RS11440	COG0175	sulfate reduction
CD178_RS11450	COG0259	pyridoxamine-phosphate oxidase activity
CD178_RS11455	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CD178_RS11460	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CD178_RS11465	COG1764	response to oxidative stress
CD178_RS11470	COG0052	Belongs to the universal ribosomal protein uS2 family
CD178_RS11475	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CD178_RS11480	COG1381	Involved in DNA repair and RecF pathway recombination
CD178_RS11485	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CD178_RS11490	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CD178_RS11495	COG0113	porphobilinogen synthase activity
CD178_RS11500	COG0531	amino acid
CD178_RS11505	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CD178_RS11550	COG0305	Participates in initiation and elongation during chromosome replication
CD178_RS11560	COG0246	Mannitol dehydrogenase
CD178_RS11570	COG4993	Dehydrogenase
CD178_RS11575	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CD178_RS11575	COG2010	Cytochrome c
CD178_RS11595	COG0148	phosphopyruvate hydratase activity
CD178_RS11605	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CD178_RS11615	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CD178_RS11620	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CD178_RS11620	COG4106	trans-aconitate 2-methyltransferase activity
CD178_RS11625	COG0596	Alpha beta hydrolase
CD178_RS11630	COG0156	8-amino-7-oxononanoate synthase activity
CD178_RS11635	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CD178_RS11650	COG2890	protein-(glutamine-N5) methyltransferase activity
CD178_RS11660	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CD178_RS11665	COG0124	histidyl-tRNA synthetase
CD178_RS11680	COG2070	2-Nitropropane dioxygenase
CD178_RS11690	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CD178_RS11695	COG2706	6-phosphogluconolactonase activity
CD178_RS11715	COG1040	competence protein
CD178_RS11725	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CD178_RS11750	COG0321	lipoyl(octanoyl) transferase activity
CD178_RS11780	COG0076	glutamate decarboxylase activity
CD178_RS11795	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CD178_RS11800	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CD178_RS11810	COG1309	transcriptional regulator
CD178_RS11815	COG1278	Cold shock
CD178_RS11820	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CD178_RS11825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CD178_RS11835	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CD178_RS11840	COG3474	cytochrome
CD178_RS11845	COG0483	inositol monophosphate 1-phosphatase activity
CD178_RS11850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CD178_RS11860	COG0534	Mate efflux family protein
CD178_RS11870	COG0628	permease
CD178_RS11880	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CD178_RS11920	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CD178_RS11925	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CD178_RS11930	COG0154	amidase activity
CD178_RS11935	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CD178_RS11950	COG0523	cobalamin synthesis protein
CD178_RS12020	COG0477	Major facilitator Superfamily
CD178_RS12035	COG1028	Short-chain dehydrogenase reductase Sdr
CD178_RS12045	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CD178_RS12065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CD178_RS12075	COG1846	Transcriptional regulator
CD178_RS12085	COG1607	acyl-coa hydrolase
CD178_RS12110	COG1289	transmembrane transporter activity
CD178_RS12135	COG1522	sequence-specific DNA binding
CD178_RS12140	COG0006	proline dipeptidase activity
CD178_RS12155	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CD178_RS12160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CD178_RS12165	COG4558	Periplasmic binding protein
CD178_RS12195	COG1953	Uracil, thiamine, allantoin
CD178_RS12230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CD178_RS12235	COG1116	anion transmembrane transporter activity
CD178_RS12240	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CD178_RS12250	COG1032	radical SAM domain protein
CD178_RS12260	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CD178_RS12285	COG0642	Histidine kinase
CD178_RS12295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CD178_RS12315	COG0436	Aminotransferase
CD178_RS12325	COG1917	Cupin 2, conserved barrel domain protein
CD178_RS12370	COG4957	zinc ion binding
CD178_RS12425	COG0653	protein targeting
CD178_RS12430	COG4974	Belongs to the 'phage' integrase family
CD178_RS12440	COG3547	Transposase (IS116 IS110 IS902 family)
CD178_RS12470	COG0662	Cupin 2, conserved barrel domain protein
CD178_RS12470	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CD178_RS12505	COG3328	transposase activity
CD178_RS12525	COG3265	gluconokinase activity
CD178_RS12535	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CD178_RS12535	COG1116	anion transmembrane transporter activity
CD178_RS12545	COG0243	molybdopterin cofactor binding
CD178_RS12550	COG2146	nitrite reductase [NAD(P)H] activity
CD178_RS12550	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CD178_RS12560	COG2223	nitrite transmembrane transporter activity
CD178_RS12595	COG1064	alcohol dehydrogenase
CD178_RS12600	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CD178_RS12615	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CD178_RS12620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CD178_RS12655	COG0583	DNA-binding transcription factor activity
CD178_RS12665	COG3634	alkyl hydroperoxide reductase activity
CD178_RS12675	COG4774	siderophore transport
CD178_RS12690	COG3128	pkhd-type hydroxylase
CD178_RS12700	COG1914	H( )-stimulated, divalent metal cation uptake system
CD178_RS12710	COG0668	transmembrane transport
CD178_RS12745	COG1640	4-alpha-glucanotransferase
CD178_RS12750	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CD178_RS12760	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CD178_RS12765	COG0297	glycogen (starch) synthase activity
CD178_RS12770	COG0058	SHG alpha-glucan phosphorylase activity
CD178_RS12795	COG2134	cdp-diacylglycerol pyrophosphatase
CD178_RS12815	COG0730	response to heat
CD178_RS12830	COG1120	ATPase activity
CD178_RS12835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CD178_RS12870	COG2010	Cytochrome c
CD178_RS12885	COG1584	GPR1 FUN34 yaaH family protein
CD178_RS12890	COG2169	Transcriptional regulator
CD178_RS12890	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CD178_RS12895	COG0495	leucyl-tRNA aminoacylation
CD178_RS12905	COG0753	catalase activity
CD178_RS12935	COG0277	FAD linked oxidase domain protein
CD178_RS12950	COG1252	NADH dehydrogenase
CD178_RS13125	COG0110	maltose O-acetyltransferase activity
CD178_RS13165	COG2211	Major facilitator Superfamily
CD178_RS13170	COG1335	isochorismatase
CD178_RS13180	COG1902	pentaerythritol trinitrate reductase activity
CD178_RS13195	COG1231	oxidoreductase activity
CD178_RS13205	COG1215	transferase activity, transferring glycosyl groups
CD178_RS13215	COG4957	zinc ion binding
CD178_RS13225	COG2186	Transcriptional regulator
CD178_RS13230	COG1301	dicarboxylic acid transport
CD178_RS13240	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CD178_RS13245	COG0513	Belongs to the DEAD box helicase family
CD178_RS13260	COG3042	response to heat
CD178_RS13285	COG2818	Glycosylase
CD178_RS13295	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CD178_RS13300	COG2837	iron assimilation
CD178_RS13320	COG4993	Dehydrogenase
CD178_RS13325	COG4993	Dehydrogenase
CD178_RS13330	COG0746	molybdenum cofactor guanylyltransferase activity
CD178_RS13335	COG1763	Mo-molybdopterin cofactor biosynthetic process
CD178_RS13340	COG0303	'Molybdopterin
CD178_RS13345	COG0243	molybdopterin cofactor binding
CD178_RS13350	COG1959	2 iron, 2 sulfur cluster binding
CD178_RS13360	COG2199	diguanylate cyclase activity
CD178_RS13360	COG2202	Pas domain
CD178_RS13360	COG2200	EAL domain
CD178_RS13380	COG2199	diguanylate cyclase activity
CD178_RS13380	COG2202	Pas domain
CD178_RS13380	COG2200	EAL domain
CD178_RS13390	COG4251	negative regulation of phosphorylation
CD178_RS13410	COG0402	S-adenosylhomocysteine deaminase activity
CD178_RS13420	COG1744	ABC transporter substrate-binding protein PnrA-like
CD178_RS13460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CD178_RS13490	COG2032	superoxide dismutase activity
CD178_RS13510	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CD178_RS13515	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CD178_RS13550	COG0437	4 iron, 4 sulfur cluster binding
CD178_RS13600	COG1959	2 iron, 2 sulfur cluster binding
CD178_RS13605	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CD178_RS13615	COG1028	Short-chain dehydrogenase reductase Sdr
CD178_RS13640	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CD178_RS13655	COG2181	nitrate reductase activity
CD178_RS13655	COG0247	lactate metabolic process
CD178_RS13660	COG0446	pyridine nucleotide-disulphide oxidoreductase
CD178_RS13660	COG1902	pentaerythritol trinitrate reductase activity
CD178_RS13680	COG1760	l-serine dehydratase
CD178_RS13690	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CD178_RS13690	COG0446	pyridine nucleotide-disulphide oxidoreductase
CD178_RS13710	COG4176	ABC-type proline glycine betaine transport system permease component
CD178_RS13720	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CD178_RS13730	COG3153	acetyltransferase
CD178_RS13730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CD178_RS13750	COG1494	fructose-1,6-bisphosphatase
CD178_RS13755	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CD178_RS13770	COG1522	sequence-specific DNA binding
CD178_RS13775	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CD178_RS13780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CD178_RS13785	COG0583	DNA-binding transcription factor activity
CD178_RS13790	COG1289	transmembrane transporter activity
CD178_RS13795	COG0281	malic enzyme
CD178_RS13800	COG0583	DNA-binding transcription factor activity
CD178_RS13830	COG1278	Cold shock
CD178_RS13835	COG0583	DNA-binding transcription factor activity
CD178_RS13850	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CD178_RS13855	COG1012	belongs to the aldehyde dehydrogenase family
CD178_RS13860	COG0420	3'-5' exonuclease activity
CD178_RS13870	COG1113	amino acid transport
CD178_RS13880	COG1054	Belongs to the UPF0176 family
CD178_RS13885	COG1695	Transcriptional regulator
CD178_RS13895	COG1028	Short-chain dehydrogenase reductase Sdr
CD178_RS13900	COG0583	DNA-binding transcription factor activity
CD178_RS13905	COG0025	NhaP-type Na H and K H
CD178_RS13915	COG0477	Major facilitator Superfamily
CD178_RS13920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CD178_RS13940	COG0583	DNA-binding transcription factor activity
CD178_RS13945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CD178_RS13950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CD178_RS13970	COG0531	amino acid
CD178_RS13975	COG1028	Short-chain dehydrogenase reductase Sdr
CD178_RS13980	COG4221	oxidoreductase activity
CD178_RS13995	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CD178_RS14000	COG1012	belongs to the aldehyde dehydrogenase family
CD178_RS14005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CD178_RS14010	COG0531	amino acid
CD178_RS14025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CD178_RS14045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CD178_RS14065	COG0596	Alpha beta hydrolase
CD178_RS14070	COG1335	isochorismatase
CD178_RS14075	COG2309	aminopeptidase activity
CD178_RS14080	COG2233	PERMEase
CD178_RS14085	COG2010	Cytochrome c
CD178_RS14085	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CD178_RS14090	COG2080	2 iron, 2 sulfur cluster binding
CD178_RS14095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CD178_RS14115	COG1802	Transcriptional regulator
CD178_RS14120	COG0500	methyltransferase
CD178_RS14125	COG1113	amino acid transport
CD178_RS14135	COG2188	Transcriptional regulator
CD178_RS14140	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CD178_RS14145	COG1984	allophanate hydrolase subunit 2
CD178_RS14150	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CD178_RS14155	COG0511	ligase activity, forming carbon-carbon bonds
CD178_RS14175	COG2814	Major facilitator Superfamily
CD178_RS14180	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CD178_RS14185	COG1609	Transcriptional regulator
CD178_RS14210	COG0443	Heat shock 70 kDa protein
CD178_RS14220	COG4993	Dehydrogenase
CD178_RS14225	COG1473	amidohydrolase
CD178_RS14235	COG1621	beta-fructofuranosidase activity
CD178_RS14250	COG1450	Type ii and iii secretion system protein
CD178_RS14290	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CD178_RS14295	COG1459	type II secretion system
CD178_RS14335	COG0022	dehydrogenase e1 component
CD178_RS14340	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CD178_RS14365	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CD178_RS14365	COG0546	phosphoglycolate phosphatase activity
CD178_RS14405	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CD178_RS14410	COG0489	protein tyrosine kinase activity
CD178_RS14410	COG3206	protein involved in exopolysaccharide biosynthesis
CD178_RS14430	COG1216	Glycosyl transferase, family 2
CD178_RS14435	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CD178_RS14435	COG2755	lipolytic protein G-D-S-L family
CD178_RS14440	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CD178_RS14455	COG0667	Aldo Keto reductase
CD178_RS14460	COG3128	pkhd-type hydroxylase
CD178_RS14465	COG4774	siderophore transport
CD178_RS14480	COG2095	MarC family integral membrane protein
CD178_RS14485	COG0584	glycerophosphoryl diester phosphodiesterase
CD178_RS14495	COG2814	Major facilitator Superfamily
CD178_RS14510	COG3685	Protein conserved in bacteria
CD178_RS14530	COG0583	DNA-binding transcription factor activity
CD178_RS14535	COG3588	fructose-bisphosphate aldolase
CD178_RS14570	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CD178_RS14585	COG0493	'glutamate synthase
CD178_RS14600	COG1953	Uracil, thiamine, allantoin
CD178_RS14620	COG1942	4-Oxalocrotonate Tautomerase
CD178_RS14625	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CD178_RS14630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CD178_RS14650	COG1253	flavin adenine dinucleotide binding
CD178_RS14655	COG1956	GAF domain-containing protein
CD178_RS14660	COG3459	Glycosyltransferase 36 associated
CD178_RS14670	COG1028	Short-chain dehydrogenase reductase Sdr
CD178_RS14700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CD178_RS14730	COG0840	transmembrane signaling receptor activity
CD178_RS14745	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CD178_RS14760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CD178_RS14780	COG4774	siderophore transport
CD178_RS14800	COG1285	pathogenesis
CD178_RS14805	COG1215	transferase activity, transferring glycosyl groups
CD178_RS14845	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CD178_RS14860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CD178_RS14885	COG1126	abc transporter atp-binding protein
CD178_RS14900	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CD178_RS14905	COG3585	molybdate ion transport
CD178_RS14920	COG0840	transmembrane signaling receptor activity
CD178_RS14925	COG0840	transmembrane signaling receptor activity
CD178_RS14935	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CD178_RS14940	COG0314	molybdopterin synthase activity
CD178_RS14950	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CD178_RS14955	COG0243	molybdopterin cofactor binding
CD178_RS14970	COG1294	oxidase, subunit
CD178_RS14975	COG1271	oxidase subunit
CD178_RS14990	COG1192	Involved in chromosome partitioning
CD178_RS14995	COG2070	2-Nitropropane dioxygenase
CD178_RS15000	COG0488	(ABC) transporter
CD178_RS15005	COG1028	Short-chain dehydrogenase reductase Sdr
CD178_RS15015	COG1012	belongs to the aldehyde dehydrogenase family
CD178_RS15035	COG1607	acyl-coa hydrolase
CD178_RS15040	COG0457	Tetratricopeptide repeat
CD178_RS15065	COG3831	ATPase activity
CD178_RS15090	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CD178_RS15100	COG0517	IMP dehydrogenase activity
CD178_RS15115	COG0516	GMP reductase activity
CD178_RS15115	COG0517	IMP dehydrogenase activity
CD178_RS15120	COG1007	ATP synthesis coupled electron transport
CD178_RS15135	COG0713	ATP synthesis coupled electron transport
CD178_RS15140	COG0839	Belongs to the complex I subunit 6 family
CD178_RS15145	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CD178_RS15150	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CD178_RS15170	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CD178_RS15170	COG0649	NAD binding
CD178_RS15175	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CD178_RS15180	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CD178_RS15185	COG2814	Major facilitator Superfamily
CD178_RS15215	COG1192	Involved in chromosome partitioning
CD178_RS15225	COG1597	lipid kinase activity
CD178_RS15235	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CD178_RS15250	COG1309	transcriptional regulator
CD178_RS15255	COG1979	alcohol dehydrogenase
CD178_RS15260	COG1012	belongs to the aldehyde dehydrogenase family
CD178_RS15270	COG0415	Belongs to the DNA photolyase family
CD178_RS15290	COG3104	oligopeptide transport
CD178_RS15315	COG3800	Transcriptional regulator
CD178_RS15315	COG1396	sequence-specific DNA binding
CD178_RS15325	COG0671	phosphoesterase, PA-phosphatase related
CD178_RS15345	COG1063	alcohol dehydrogenase
CD178_RS15350	COG4774	siderophore transport
CD178_RS15360	COG1595	DNA-templated transcription, initiation
CD178_RS15375	COG1408	metallophosphoesterase
CD178_RS15395	COG1012	belongs to the aldehyde dehydrogenase family
CD178_RS15400	COG0667	Aldo Keto reductase
CD178_RS15405	COG1028	Short-chain dehydrogenase reductase Sdr
CD178_RS15415	COG1028	Short-chain dehydrogenase reductase Sdr
CD178_RS15445	COG1309	transcriptional regulator
CD178_RS15455	COG1294	oxidase, subunit
CD178_RS15460	COG1271	oxidase subunit
CD178_RS15465	COG1012	belongs to the aldehyde dehydrogenase family
CD178_RS15475	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CD178_RS15480	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CD178_RS15485	COG4208	sulfate ABC transporter
CD178_RS15490	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CD178_RS15500	COG2011	ABC-type metal ion transport system permease component
CD178_RS15510	COG1464	Belongs to the NlpA lipoprotein family
CD178_RS15535	COG0840	transmembrane signaling receptor activity
CD178_RS15555	COG0306	phosphate transporter
CD178_RS15580	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CD178_RS15585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CD178_RS15595	COG4206	TonB-dependent receptor
CD178_RS15610	COG1492	cobalamin metabolic process
CD178_RS15680	COG0071	Belongs to the small heat shock protein (HSP20) family
CD178_RS15700	COG3077	Addiction module antitoxin, RelB DinJ family
CD178_RS15705	COG2026	Addiction module toxin, RelE StbE family
CD178_RS15750	COG3119	arylsulfatase activity
CD178_RS15830	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CD178_RS15835	COG4372	Transposase
CD178_RS15850	COG1902	pentaerythritol trinitrate reductase activity
CD178_RS15865	COG1294	oxidase, subunit
CD178_RS15870	COG1271	oxidase subunit
CD178_RS15880	COG2072	flavoprotein involved in K transport
CD178_RS15895	COG2144	transferase activity, transferring acyl groups
CD178_RS15920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CD178_RS15975	COG1309	transcriptional regulator
CD178_RS15980	COG0625	glutathione transferase activity
CD178_RS15990	COG1196	nuclear chromosome segregation
CD178_RS15990	COG0741	lytic transglycosylase activity
CD178_RS15990	COG0739	heme binding
CD178_RS15995	COG5489	Protein of unknown function (DUF736)
CD178_RS16015	COG0776	regulation of translation
CD178_RS16045	COG4221	oxidoreductase activity
CD178_RS16055	COG3180	Ammonia monooxygenase
CD178_RS16060	COG1335	isochorismatase
CD178_RS16065	COG1309	transcriptional regulator
CD178_RS16070	COG0596	Alpha beta hydrolase
CD178_RS16100	COG1475	DNA binding
CD178_RS16155	COG0629	single-stranded DNA binding
CD178_RS16245	COG2361	Protein of unknown function DUF86
CD178_RS16345	COG0436	Aminotransferase
CD178_RS16420	COG1192	Involved in chromosome partitioning
CD178_RS16450	COG1475	DNA binding
CD178_RS16525	COG0210	DNA helicase
CD178_RS16530	COG3437	response regulator, receiver
CD178_RS16550	COG3750	Belongs to the UPF0335 family
CD178_RS16565	COG4566	intracellular signal transduction
CD178_RS16570	COG4191	Histidine kinase
CD178_RS16595	COG0281	malic enzyme
CD178_RS16615	COG4227	nucleotidyltransferase activity
CD178_RS16645	COG0629	single-stranded DNA binding
CD178_RS16680	COG2336	PFAM SpoVT AbrB
CD178_RS16685	COG2337	Toxic component of a toxin-antitoxin (TA) module
CD178_RS16705	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CD178_RS16715	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CD178_RS16750	COG3119	arylsulfatase activity
CD178_RS16755	COG0583	DNA-binding transcription factor activity
CD178_RS16775	COG0675	Transposase, IS605 OrfB family
CD178_RS16830	COG0587	DNA-directed DNA polymerase activity
CD178_RS16875	COG0675	Transposase, IS605 OrfB family
CD178_RS16905	COG4974	Belongs to the 'phage' integrase family
CD178_RS16910	COG0517	IMP dehydrogenase activity
CD178_RS16915	COG4372	Transposase
CD178_RS16920	COG3436	PFAM IS66 Orf2 family protein
CD178_RS16940	COG0667	Aldo Keto reductase
CD178_RS16965	COG4974	Belongs to the 'phage' integrase family
CD178_RS16970	COG4974	Belongs to the 'phage' integrase family
CD178_RS16975	COG3177	Filamentation induced by cAMP protein fic
CD178_RS16980	COG4974	Belongs to the 'phage' integrase family
CD178_RS17000	COG4372	Transposase
CD178_RS17040	COG1671	Belongs to the UPF0178 family
CD178_RS17065	COG0830	nickel cation binding
CD178_RS17090	COG0477	Major facilitator Superfamily
CD178_RS17130	COG1074	ATP-dependent DNA helicase activity
CD178_RS17130	COG1074	ATP-dependent DNA helicase activity
CD178_RS17140	COG3547	Transposase (IS116 IS110 IS902 family)
CD178_RS17150	COG2337	Toxic component of a toxin-antitoxin (TA) module
CD178_RS17155	COG2336	PFAM SpoVT AbrB
CD178_RS17175	COG1192	Involved in chromosome partitioning
CD178_RS17180	COG1475	DNA binding
CD178_RS17195	COG4372	Transposase
CD178_RS17230	COG0848	biopolymer transport protein
CD178_RS17240	COG0829	nickel cation binding
CD178_RS17245	COG0831	urea catabolic process
CD178_RS17250	COG0832	Belongs to the urease beta subunit family
CD178_RS17260	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CD178_RS17270	COG3551	Protein conserved in bacteria
CD178_RS17305	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CD178_RS17310	COG1061	Type III restriction enzyme res subunit
CD178_RS17315	COG1002	Type II restriction enzyme, methylase subunits
CD178_RS17330	COG4115	mRNA cleavage
CD178_RS17335	COG2161	toxin-antitoxin pair type II binding
CD178_RS17400	COG1192	Involved in chromosome partitioning