locus-tag	class	description
KSAC_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KSAC_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KSAC_RS00025	COG0546	phosphoglycolate phosphatase activity
KSAC_RS00030	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KSAC_RS00035	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KSAC_RS00050	COG2022	thiamine diphosphate biosynthetic process
KSAC_RS00070	COG0019	diaminopimelate decarboxylase activity
KSAC_RS00075	COG0295	cytidine deaminase activity
KSAC_RS00080	COG0165	Argininosuccinate lyase
KSAC_RS00090	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KSAC_RS00095	COG0237	dephospho-CoA kinase activity
KSAC_RS00100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KSAC_RS00115	COG1136	(ABC) transporter
KSAC_RS00130	COG0659	secondary active sulfate transmembrane transporter activity
KSAC_RS00140	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KSAC_RS00145	COG0602	queuosine metabolic process
KSAC_RS00150	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KSAC_RS00160	COG0045	succinate-CoA ligase (ADP-forming) activity
KSAC_RS00180	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KSAC_RS00190	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KSAC_RS00200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KSAC_RS00205	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KSAC_RS00210	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KSAC_RS00220	COG0483	inositol monophosphate 1-phosphatase activity
KSAC_RS00265	COG0156	8-amino-7-oxononanoate synthase activity
KSAC_RS00275	COG0318	PFAM AMP-dependent synthetase and ligase
KSAC_RS00390	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KSAC_RS00395	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KSAC_RS00460	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
KSAC_RS00500	COG4953	penicillin-binding protein 1C
KSAC_RS00505	COG2373	Large extracellular alpha-helical protein
KSAC_RS00525	COG3511	phospholipase C
KSAC_RS00565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KSAC_RS00570	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KSAC_RS00575	COG1942	4-Oxalocrotonate Tautomerase
KSAC_RS00595	COG1953	Uracil, thiamine, allantoin
KSAC_RS00610	COG0493	'glutamate synthase
KSAC_RS00625	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KSAC_RS00640	COG3588	fructose-bisphosphate aldolase
KSAC_RS00650	COG0583	DNA-binding transcription factor activity
KSAC_RS00670	COG3685	Protein conserved in bacteria
KSAC_RS00685	COG2814	Major facilitator Superfamily
KSAC_RS00695	COG0584	glycerophosphoryl diester phosphodiesterase
KSAC_RS00700	COG2095	MarC family integral membrane protein
KSAC_RS00715	COG4774	siderophore transport
KSAC_RS00720	COG3128	pkhd-type hydroxylase
KSAC_RS00725	COG0667	Aldo Keto reductase
KSAC_RS00740	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KSAC_RS00745	COG2755	lipolytic protein G-D-S-L family
KSAC_RS00745	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KSAC_RS00750	COG1216	Glycosyl transferase, family 2
KSAC_RS00770	COG0489	protein tyrosine kinase activity
KSAC_RS00770	COG3206	protein involved in exopolysaccharide biosynthesis
KSAC_RS00775	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KSAC_RS00810	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KSAC_RS00810	COG0546	phosphoglycolate phosphatase activity
KSAC_RS00835	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KSAC_RS00840	COG0022	dehydrogenase e1 component
KSAC_RS00880	COG1459	type II secretion system
KSAC_RS00885	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KSAC_RS00920	COG1450	Type ii and iii secretion system protein
KSAC_RS00935	COG1621	beta-fructofuranosidase activity
KSAC_RS00945	COG1473	amidohydrolase
KSAC_RS00950	COG4993	Dehydrogenase
KSAC_RS00960	COG0443	Heat shock 70 kDa protein
KSAC_RS00985	COG1609	Transcriptional regulator
KSAC_RS00990	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KSAC_RS00995	COG2814	Major facilitator Superfamily
KSAC_RS01000	COG2814	Major facilitator Superfamily
KSAC_RS01015	COG0511	ligase activity, forming carbon-carbon bonds
KSAC_RS01020	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
KSAC_RS01025	COG1984	allophanate hydrolase subunit 2
KSAC_RS01030	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
KSAC_RS01035	COG2188	Transcriptional regulator
KSAC_RS01045	COG1113	amino acid transport
KSAC_RS01050	COG0500	methyltransferase
KSAC_RS01055	COG1802	Transcriptional regulator
KSAC_RS01075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KSAC_RS01080	COG2080	2 iron, 2 sulfur cluster binding
KSAC_RS01085	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KSAC_RS01085	COG2010	Cytochrome c
KSAC_RS01090	COG2233	PERMEase
KSAC_RS01095	COG2309	aminopeptidase activity
KSAC_RS01100	COG1335	isochorismatase
KSAC_RS01105	COG0596	Alpha beta hydrolase
KSAC_RS01125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KSAC_RS01150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KSAC_RS01165	COG0531	amino acid
KSAC_RS01170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KSAC_RS01175	COG1012	belongs to the aldehyde dehydrogenase family
KSAC_RS01180	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KSAC_RS01195	COG4221	oxidoreductase activity
KSAC_RS01200	COG1028	Short-chain dehydrogenase reductase Sdr
KSAC_RS01205	COG0531	amino acid
KSAC_RS01225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KSAC_RS01235	COG0583	DNA-binding transcription factor activity
KSAC_RS01245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KSAC_RS01250	COG0477	Major facilitator Superfamily
KSAC_RS01255	COG0025	NhaP-type Na H and K H
KSAC_RS01260	COG0583	DNA-binding transcription factor activity
KSAC_RS01265	COG1028	Short-chain dehydrogenase reductase Sdr
KSAC_RS01275	COG1695	Transcriptional regulator
KSAC_RS01280	COG1054	Belongs to the UPF0176 family
KSAC_RS01290	COG1113	amino acid transport
KSAC_RS01300	COG0420	3'-5' exonuclease activity
KSAC_RS01305	COG1012	belongs to the aldehyde dehydrogenase family
KSAC_RS01310	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KSAC_RS01325	COG0583	DNA-binding transcription factor activity
KSAC_RS01330	COG1278	Cold shock
KSAC_RS01360	COG0583	DNA-binding transcription factor activity
KSAC_RS01365	COG0281	malic enzyme
KSAC_RS01370	COG1289	transmembrane transporter activity
KSAC_RS01375	COG0583	DNA-binding transcription factor activity
KSAC_RS01380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KSAC_RS01385	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KSAC_RS01390	COG1522	sequence-specific DNA binding
KSAC_RS01405	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KSAC_RS01410	COG1494	fructose-1,6-bisphosphatase
KSAC_RS01430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KSAC_RS01430	COG3153	acetyltransferase
KSAC_RS01440	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KSAC_RS01450	COG4176	ABC-type proline glycine betaine transport system permease component
KSAC_RS01470	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KSAC_RS01470	COG0446	pyridine nucleotide-disulphide oxidoreductase
KSAC_RS01480	COG1760	l-serine dehydratase
KSAC_RS01500	COG1902	pentaerythritol trinitrate reductase activity
KSAC_RS01500	COG0446	pyridine nucleotide-disulphide oxidoreductase
KSAC_RS01505	COG0247	lactate metabolic process
KSAC_RS01505	COG2181	nitrate reductase activity
KSAC_RS01520	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
KSAC_RS01545	COG1028	Short-chain dehydrogenase reductase Sdr
KSAC_RS01555	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KSAC_RS01560	COG1959	2 iron, 2 sulfur cluster binding
KSAC_RS01610	COG0437	4 iron, 4 sulfur cluster binding
KSAC_RS01645	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KSAC_RS01650	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KSAC_RS01665	COG2032	superoxide dismutase activity
KSAC_RS01695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KSAC_RS01735	COG1744	ABC transporter substrate-binding protein PnrA-like
KSAC_RS01745	COG0402	S-adenosylhomocysteine deaminase activity
KSAC_RS01760	COG4251	negative regulation of phosphorylation
KSAC_RS01770	COG2200	EAL domain
KSAC_RS01770	COG2202	Pas domain
KSAC_RS01770	COG2199	diguanylate cyclase activity
KSAC_RS01790	COG2199	diguanylate cyclase activity
KSAC_RS01790	COG2200	EAL domain
KSAC_RS01790	COG2202	Pas domain
KSAC_RS01800	COG1959	2 iron, 2 sulfur cluster binding
KSAC_RS01805	COG0243	molybdopterin cofactor binding
KSAC_RS01810	COG0303	'Molybdopterin
KSAC_RS01815	COG1763	Mo-molybdopterin cofactor biosynthetic process
KSAC_RS01820	COG0746	molybdenum cofactor guanylyltransferase activity
KSAC_RS01825	COG4993	Dehydrogenase
KSAC_RS01850	COG2837	iron assimilation
KSAC_RS01855	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KSAC_RS01865	COG2818	Glycosylase
KSAC_RS01890	COG3042	response to heat
KSAC_RS01905	COG0513	Belongs to the DEAD box helicase family
KSAC_RS01910	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KSAC_RS01920	COG1301	dicarboxylic acid transport
KSAC_RS01925	COG2186	Transcriptional regulator
KSAC_RS01935	COG4957	zinc ion binding
KSAC_RS01940	COG1215	transferase activity, transferring glycosyl groups
KSAC_RS01945	COG1231	oxidoreductase activity
KSAC_RS01960	COG1902	pentaerythritol trinitrate reductase activity
KSAC_RS01970	COG1335	isochorismatase
KSAC_RS01975	COG2211	Major facilitator Superfamily
KSAC_RS02015	COG0110	maltose O-acetyltransferase activity
KSAC_RS02125	COG0071	Belongs to the small heat shock protein (HSP20) family
KSAC_RS02190	COG1252	NADH dehydrogenase
KSAC_RS02205	COG0277	FAD linked oxidase domain protein
KSAC_RS02225	COG0753	catalase activity
KSAC_RS02235	COG0495	leucyl-tRNA aminoacylation
KSAC_RS02240	COG2169	Transcriptional regulator
KSAC_RS02240	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KSAC_RS02245	COG1584	GPR1 FUN34 yaaH family protein
KSAC_RS02275	COG2010	Cytochrome c
KSAC_RS02310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KSAC_RS02315	COG1120	ATPase activity
KSAC_RS02325	COG0085	RNA polymerase activity
KSAC_RS02335	COG0730	response to heat
KSAC_RS02355	COG2134	cdp-diacylglycerol pyrophosphatase
KSAC_RS02380	COG0058	SHG alpha-glucan phosphorylase activity
KSAC_RS02385	COG0297	glycogen (starch) synthase activity
KSAC_RS02390	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KSAC_RS02400	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KSAC_RS02405	COG1640	4-alpha-glucanotransferase
KSAC_RS02440	COG0668	transmembrane transport
KSAC_RS02445	COG1914	H( )-stimulated, divalent metal cation uptake system
KSAC_RS02455	COG3128	pkhd-type hydroxylase
KSAC_RS02470	COG4774	siderophore transport
KSAC_RS02480	COG3634	alkyl hydroperoxide reductase activity
KSAC_RS02490	COG0583	DNA-binding transcription factor activity
KSAC_RS02525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KSAC_RS02530	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KSAC_RS02545	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KSAC_RS02550	COG1064	alcohol dehydrogenase
KSAC_RS02580	COG0848	biopolymer transport protein
KSAC_RS02590	COG0829	nickel cation binding
KSAC_RS02595	COG0831	urea catabolic process
KSAC_RS02600	COG0832	Belongs to the urease beta subunit family
KSAC_RS02605	COG0804	urea catabolic process
KSAC_RS02610	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
KSAC_RS02615	COG0830	nickel cation binding
KSAC_RS02620	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
KSAC_RS02625	COG1028	Short-chain dehydrogenase reductase Sdr
KSAC_RS02630	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KSAC_RS02640	COG0477	Major facilitator Superfamily
KSAC_RS02650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KSAC_RS02660	COG1917	Cupin 2, conserved barrel domain protein
KSAC_RS02670	COG0436	Aminotransferase
KSAC_RS02690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KSAC_RS02700	COG0642	Histidine kinase
KSAC_RS02710	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
KSAC_RS02725	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
KSAC_RS02740	COG1032	radical SAM domain protein
KSAC_RS02750	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KSAC_RS02755	COG1116	anion transmembrane transporter activity
KSAC_RS02760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KSAC_RS02795	COG1953	Uracil, thiamine, allantoin
KSAC_RS02825	COG4558	Periplasmic binding protein
KSAC_RS02830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KSAC_RS02835	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
KSAC_RS02850	COG0006	proline dipeptidase activity
KSAC_RS02855	COG1522	sequence-specific DNA binding
KSAC_RS02880	COG1289	transmembrane transporter activity
KSAC_RS02905	COG0642	Histidine kinase
KSAC_RS02950	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KSAC_RS02960	COG0789	Transcriptional regulator
KSAC_RS02990	COG1607	acyl-coa hydrolase
KSAC_RS03000	COG1846	Transcriptional regulator
KSAC_RS03010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KSAC_RS03030	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
KSAC_RS03040	COG1028	Short-chain dehydrogenase reductase Sdr
KSAC_RS03055	COG0477	Major facilitator Superfamily
KSAC_RS03090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KSAC_RS03115	COG2144	transferase activity, transferring acyl groups
KSAC_RS03130	COG2072	flavoprotein involved in K transport
KSAC_RS03150	COG0582	viral genome integration into host DNA
KSAC_RS03160	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KSAC_RS03165	COG0154	amidase activity
KSAC_RS03170	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KSAC_RS03175	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KSAC_RS03215	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
KSAC_RS03225	COG0628	permease
KSAC_RS03235	COG0534	Mate efflux family protein
KSAC_RS03245	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KSAC_RS03250	COG0483	inositol monophosphate 1-phosphatase activity
KSAC_RS03255	COG3474	cytochrome
KSAC_RS03260	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
KSAC_RS03270	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KSAC_RS03275	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KSAC_RS03280	COG1278	Cold shock
KSAC_RS03285	COG1309	transcriptional regulator
KSAC_RS03295	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
KSAC_RS03300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KSAC_RS03315	COG0076	glutamate decarboxylase activity
KSAC_RS03345	COG0321	lipoyl(octanoyl) transferase activity
KSAC_RS03370	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KSAC_RS03380	COG1040	competence protein
KSAC_RS03400	COG2706	6-phosphogluconolactonase activity
KSAC_RS03405	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KSAC_RS03415	COG2070	2-Nitropropane dioxygenase
KSAC_RS03425	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KSAC_RS03430	COG0124	histidyl-tRNA synthetase
KSAC_RS03435	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KSAC_RS03445	COG2890	protein-(glutamine-N5) methyltransferase activity
KSAC_RS03460	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KSAC_RS03465	COG0156	8-amino-7-oxononanoate synthase activity
KSAC_RS03470	COG0596	Alpha beta hydrolase
KSAC_RS03475	COG4106	trans-aconitate 2-methyltransferase activity
KSAC_RS03475	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KSAC_RS03480	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KSAC_RS03490	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KSAC_RS03500	COG0148	phosphopyruvate hydratase activity
KSAC_RS03520	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KSAC_RS03520	COG2010	Cytochrome c
KSAC_RS03525	COG4993	Dehydrogenase
KSAC_RS03535	COG0246	Mannitol dehydrogenase
KSAC_RS03545	COG0305	Participates in initiation and elongation during chromosome replication
KSAC_RS03580	COG2988	succinylglutamate desuccinylase activity
KSAC_RS03585	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KSAC_RS03590	COG0531	amino acid
KSAC_RS03595	COG0113	porphobilinogen synthase activity
KSAC_RS03600	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
KSAC_RS03605	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KSAC_RS03610	COG1381	Involved in DNA repair and RecF pathway recombination
KSAC_RS03615	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KSAC_RS03620	COG0052	Belongs to the universal ribosomal protein uS2 family
KSAC_RS03625	COG1764	response to oxidative stress
KSAC_RS03630	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KSAC_RS03635	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KSAC_RS03640	COG0259	pyridoxamine-phosphate oxidase activity
KSAC_RS03650	COG0175	sulfate reduction
KSAC_RS03655	COG0175	sulfate reduction
KSAC_RS03670	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KSAC_RS03680	COG1519	Transferase
KSAC_RS03685	COG1663	tetraacyldisaccharide 4'-kinase activity
KSAC_RS03705	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KSAC_RS03745	COG1335	isochorismatase
KSAC_RS03750	COG1160	GTP binding
KSAC_RS03775	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KSAC_RS03785	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KSAC_RS03795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KSAC_RS03795	COG0072	phenylalanine-tRNA ligase activity
KSAC_RS03800	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KSAC_RS03805	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KSAC_RS03810	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KSAC_RS03815	COG1028	Short-chain dehydrogenase reductase Sdr
KSAC_RS03825	COG0655	NAD(P)H dehydrogenase (quinone) activity
KSAC_RS03830	COG0583	DNA-binding transcription factor activity
KSAC_RS03835	COG1741	Belongs to the pirin family
KSAC_RS03860	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
KSAC_RS03865	COG1940	carbohydrate kinase activity
KSAC_RS03870	COG0425	Belongs to the sulfur carrier protein TusA family
KSAC_RS03875	COG1722	exodeoxyribonuclease VII activity
KSAC_RS03885	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KSAC_RS03890	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
KSAC_RS03895	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KSAC_RS03900	COG0137	argininosuccinate synthase activity
KSAC_RS03905	COG0545	Peptidyl-prolyl cis-trans isomerase
KSAC_RS03915	COG0180	Tryptophanyl-tRNA synthetase
KSAC_RS03920	COG0432	Pfam Uncharacterised protein family UPF0047
KSAC_RS03925	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
KSAC_RS03930	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
KSAC_RS03935	COG3781	membrane
KSAC_RS03945	COG2824	Alkylphosphonate utilization operon protein PhnA
KSAC_RS03950	COG2814	Major facilitator Superfamily
KSAC_RS03960	COG0729	surface antigen
KSAC_RS03965	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KSAC_RS03970	COG1702	phosphate starvation-inducible protein PhoH
KSAC_RS03975	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KSAC_RS03990	COG1196	nuclear chromosome segregation
KSAC_RS04005	COG1605	Chorismate mutase
KSAC_RS04005	COG0287	Prephenate dehydrogenase
KSAC_RS04025	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KSAC_RS04030	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KSAC_RS04035	COG0142	geranyltranstransferase activity
KSAC_RS04045	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KSAC_RS04050	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KSAC_RS04050	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KSAC_RS04055	COG0314	molybdopterin synthase activity
KSAC_RS04060	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
KSAC_RS04075	COG0322	excinuclease ABC activity
KSAC_RS04080	COG0708	Exodeoxyribonuclease III
KSAC_RS04085	COG0745	RESPONSE REGULATOR receiver
KSAC_RS04100	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KSAC_RS04100	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KSAC_RS04110	COG0321	lipoyl(octanoyl) transferase activity
KSAC_RS04110	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KSAC_RS04115	COG0084	hydrolase, TatD family'
KSAC_RS04130	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KSAC_RS04135	COG1686	Belongs to the peptidase S11 family
KSAC_RS04145	COG0586	Pfam SNARE associated Golgi protein
KSAC_RS04160	COG1968	undecaprenyl-diphosphatase activity
KSAC_RS04205	COG3328	transposase activity
KSAC_RS04285	COG0305	Participates in initiation and elongation during chromosome replication
KSAC_RS04335	COG0616	signal peptide processing
KSAC_RS04390	COG1196	nuclear chromosome segregation
KSAC_RS04390	COG0739	heme binding
KSAC_RS04390	COG0741	lytic transglycosylase activity
KSAC_RS04410	COG4381	Mu-like prophage protein gp46
KSAC_RS04505	COG0583	DNA-binding transcription factor activity
KSAC_RS04535	COG1522	sequence-specific DNA binding
KSAC_RS04540	COG2515	1-aminocyclopropane-1-carboxylate deaminase
KSAC_RS04545	COG1272	protein, Hemolysin III
KSAC_RS04550	COG2814	Major facilitator Superfamily
KSAC_RS04580	COG0626	cystathionine gamma-synthase activity
KSAC_RS04585	COG2897	thiosulfate sulfurtransferase activity
KSAC_RS04590	COG0628	permease
KSAC_RS04600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KSAC_RS04605	COG0792	nuclease activity
KSAC_RS04615	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KSAC_RS04620	COG0271	Belongs to the BolA IbaG family
KSAC_RS04625	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KSAC_RS04630	COG0047	phosphoribosylformylglycinamidine synthase activity
KSAC_RS04640	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KSAC_RS04645	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KSAC_RS04655	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KSAC_RS04660	COG0861	Integral membrane protein TerC family
KSAC_RS04665	COG0741	lytic transglycosylase activity
KSAC_RS04670	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KSAC_RS04675	COG1546	Belongs to the CinA family
KSAC_RS04675	COG1058	Belongs to the CinA family
KSAC_RS04685	COG2867	negative regulation of translational initiation
KSAC_RS04690	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KSAC_RS04695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KSAC_RS04700	COG0508	dehydrogenase complex catalyzes the overall conversion of
KSAC_RS04705	COG0508	dehydrogenase complex catalyzes the overall conversion of
KSAC_RS04705	COG0022	dehydrogenase e1 component
KSAC_RS04710	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KSAC_RS04715	COG0315	cyclic pyranopterin monophosphate synthase activity
KSAC_RS04720	COG0134	indole-3-glycerol-phosphate synthase activity
KSAC_RS04725	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KSAC_RS04735	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KSAC_RS04745	COG0149	triose-phosphate isomerase activity
KSAC_RS04750	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KSAC_RS04755	COG0504	CTP synthase activity
KSAC_RS04760	COG2877	3-deoxy-8-phosphooctulonate synthase activity
KSAC_RS04765	COG0438	transferase activity, transferring glycosyl groups
KSAC_RS04780	COG5001	Diguanylate cyclase
KSAC_RS04780	COG3300	MHYT domain
KSAC_RS04815	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KSAC_RS04820	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KSAC_RS04850	COG0582	viral genome integration into host DNA
KSAC_RS04855	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KSAC_RS04855	COG0519	Catalyzes the synthesis of GMP from XMP
KSAC_RS04880	COG1522	sequence-specific DNA binding
KSAC_RS04885	COG0492	ferredoxin-NADP+ reductase activity
KSAC_RS04890	COG0583	DNA-binding transcription factor activity
KSAC_RS04895	COG0776	regulation of translation
KSAC_RS04900	COG0616	signal peptide processing
KSAC_RS04905	COG4957	zinc ion binding
KSAC_RS04920	COG1573	uracil-dna glycosylase
KSAC_RS04925	COG1289	transmembrane transporter activity
KSAC_RS04930	COG0402	S-adenosylhomocysteine deaminase activity
KSAC_RS04940	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KSAC_RS04945	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KSAC_RS04950	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KSAC_RS04955	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KSAC_RS04965	COG3750	Belongs to the UPF0335 family
KSAC_RS04970	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KSAC_RS04980	COG0657	acetylesterase activity
KSAC_RS04990	COG2001	Belongs to the MraZ family
KSAC_RS04995	COG0275	rRNA processing
KSAC_RS05010	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KSAC_RS05015	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KSAC_RS05020	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KSAC_RS05025	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KSAC_RS05035	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KSAC_RS05040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KSAC_RS05045	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KSAC_RS05050	COG1181	Belongs to the D-alanine--D-alanine ligase family
KSAC_RS05055	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KSAC_RS05060	COG0849	cell division
KSAC_RS05070	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
KSAC_RS05075	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KSAC_RS05085	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KSAC_RS05090	COG1744	ABC transporter substrate-binding protein PnrA-like
KSAC_RS05095	COG3845	ABC transporter
KSAC_RS05100	COG4603	Belongs to the binding-protein-dependent transport system permease family
KSAC_RS05105	COG1079	Belongs to the binding-protein-dependent transport system permease family
KSAC_RS05145	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
KSAC_RS05185	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KSAC_RS05185	COG0456	acetyltransferase
KSAC_RS05190	COG1671	Belongs to the UPF0178 family
KSAC_RS05200	COG2244	polysaccharide biosynthetic process
KSAC_RS05225	COG0513	Belongs to the DEAD box helicase family
KSAC_RS05230	COG0778	Nitroreductase
KSAC_RS05235	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KSAC_RS05235	COG2813	Specifically methylates the guanine in position
KSAC_RS05240	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KSAC_RS05250	COG1136	(ABC) transporter
KSAC_RS05260	COG0442	prolyl-tRNA aminoacylation
KSAC_RS05275	COG1007	ATP synthesis coupled electron transport
KSAC_RS05285	COG0713	ATP synthesis coupled electron transport
KSAC_RS05295	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KSAC_RS05300	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KSAC_RS05305	COG1034	ATP synthesis coupled electron transport
KSAC_RS05315	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
KSAC_RS05320	COG0649	NAD binding
KSAC_RS05325	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KSAC_RS05330	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KSAC_RS05335	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KSAC_RS05350	COG0776	regulation of translation
KSAC_RS05360	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KSAC_RS05365	COG0740	serine-type endopeptidase activity
KSAC_RS05370	COG0544	peptidyl-prolyl cis-trans isomerase activity
KSAC_RS05390	COG0513	Belongs to the DEAD box helicase family
KSAC_RS05405	COG2151	metal-sulfur cluster biosynthetic enzyme
KSAC_RS05415	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KSAC_RS05420	COG0719	Fe-S assembly protein
KSAC_RS05425	COG0396	ATPase activity
KSAC_RS05430	COG0719	Fe-S assembly protein
KSAC_RS05440	COG2733	membrane
KSAC_RS05445	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
KSAC_RS05455	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KSAC_RS05460	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KSAC_RS05470	COG5265	(ABC) transporter
KSAC_RS05485	COG0628	permease
KSAC_RS05500	COG0776	regulation of translation
KSAC_RS05505	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KSAC_RS05510	COG0416	fatty acid biosynthetic process
KSAC_RS05515	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KSAC_RS05535	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KSAC_RS05540	COG0242	peptide deformylase activity
KSAC_RS05555	COG0745	RESPONSE REGULATOR receiver
KSAC_RS05560	COG0473	3-isopropylmalate dehydrogenase activity
KSAC_RS05565	COG0066	3-isopropylmalate dehydratase activity
KSAC_RS05570	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KSAC_RS05575	COG0335	large ribosomal subunit rRNA binding
KSAC_RS05580	COG0336	Belongs to the RNA methyltransferase TrmD family
KSAC_RS05585	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KSAC_RS05590	COG0228	four-way junction DNA binding
KSAC_RS05605	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KSAC_RS05610	COG0581	inorganic phosphate transmembrane transporter activity
KSAC_RS05615	COG0573	inorganic phosphate transmembrane transporter activity
KSAC_RS05625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KSAC_RS05630	COG1116	anion transmembrane transporter activity
KSAC_RS05635	COG0328	RNA-DNA hybrid ribonuclease activity
KSAC_RS05640	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KSAC_RS05645	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KSAC_RS05655	COG1297	OPT oligopeptide transporter protein
KSAC_RS05670	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
KSAC_RS05685	COG2096	Adenosyltransferase
KSAC_RS05690	COG3265	gluconokinase activity
KSAC_RS05705	COG0436	Aminotransferase
KSAC_RS05715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KSAC_RS05730	COG1032	radical SAM domain protein
KSAC_RS05745	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
KSAC_RS05750	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
KSAC_RS05800	COG2884	Cell division ATP-binding protein ftsE
KSAC_RS05820	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
KSAC_RS05825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KSAC_RS05835	COG0688	phosphatidylethanolamine metabolic process
KSAC_RS05845	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KSAC_RS05850	COG0649	NAD binding
KSAC_RS05875	COG0656	L-ascorbic acid biosynthetic process
KSAC_RS05885	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KSAC_RS05895	COG0009	L-threonylcarbamoyladenylate synthase
KSAC_RS05905	COG0277	FAD linked oxidase domain protein
KSAC_RS05920	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
KSAC_RS05930	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KSAC_RS05935	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KSAC_RS05940	COG0359	binds to the 23S rRNA
KSAC_RS05945	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KSAC_RS05950	COG0360	Binds together with S18 to 16S ribosomal RNA
KSAC_RS05960	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KSAC_RS05965	COG0358	DNA primase activity
KSAC_RS05975	COG0505	Belongs to the CarA family
KSAC_RS05980	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KSAC_RS05985	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KSAC_RS05995	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KSAC_RS06000	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KSAC_RS06005	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KSAC_RS06015	COG0793	Belongs to the peptidase S41A family
KSAC_RS06020	COG1051	belongs to the nudix hydrolase family
KSAC_RS06025	COG0494	nUDIX hydrolase
KSAC_RS06030	COG2814	Major facilitator Superfamily
KSAC_RS06035	COG1566	PFAM secretion protein HlyD family protein
KSAC_RS06040	COG1132	(ABC) transporter
KSAC_RS06045	COG0617	tRNA 3'-terminal CCA addition
KSAC_RS06055	COG0714	Associated with various cellular activities
KSAC_RS06085	COG2189	Belongs to the N(4) N(6)-methyltransferase family
KSAC_RS06090	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KSAC_RS06100	COG0477	Major facilitator Superfamily
KSAC_RS06110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KSAC_RS06135	COG1116	anion transmembrane transporter activity
KSAC_RS06150	COG0203	ribosomal protein L17
KSAC_RS06155	COG0202	RNA polymerase activity
KSAC_RS06160	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KSAC_RS06165	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KSAC_RS06170	COG0563	adenylate kinase activity
KSAC_RS06175	COG0201	protein transport
KSAC_RS06180	COG0200	Binds to the 23S rRNA
KSAC_RS06185	COG1841	ribosomal large subunit assembly
KSAC_RS06190	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KSAC_RS06195	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KSAC_RS06200	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KSAC_RS06205	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KSAC_RS06210	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KSAC_RS06215	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KSAC_RS06220	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KSAC_RS06225	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KSAC_RS06230	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KSAC_RS06235	COG0255	Belongs to the universal ribosomal protein uL29 family
KSAC_RS06240	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KSAC_RS06245	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KSAC_RS06250	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KSAC_RS06255	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KSAC_RS06260	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KSAC_RS06265	COG0089	rRNA binding
KSAC_RS06270	COG0088	Forms part of the polypeptide exit tunnel
KSAC_RS06275	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KSAC_RS06280	COG0051	transcription antitermination factor activity, RNA binding
KSAC_RS06285	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KSAC_RS06290	COG0049	tRNA binding
KSAC_RS06295	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KSAC_RS06300	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KSAC_RS06305	COG0085	RNA polymerase activity
KSAC_RS06310	COG0222	ribosome binding
KSAC_RS06315	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KSAC_RS06320	COG0081	regulation of translation
KSAC_RS06325	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KSAC_RS06360	COG1301	dicarboxylic acid transport
KSAC_RS06365	COG0477	Major facilitator Superfamily
KSAC_RS06380	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KSAC_RS06400	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
KSAC_RS06430	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KSAC_RS06440	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
KSAC_RS06445	COG1138	Cytochrome C-type biogenesis protein
KSAC_RS06450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KSAC_RS06455	COG3088	subunit of a heme lyase
KSAC_RS06465	COG5508	conserved small protein
KSAC_RS06480	COG0612	Peptidase, M16
KSAC_RS06485	COG0539	negative regulation of cytoplasmic translation
KSAC_RS06490	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KSAC_RS06495	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KSAC_RS06505	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KSAC_RS06510	COG1028	Short-chain dehydrogenase reductase Sdr
KSAC_RS06515	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KSAC_RS06520	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KSAC_RS06540	COG0024	Methionine aminopeptidase
KSAC_RS06545	COG1686	Belongs to the peptidase S11 family
KSAC_RS06560	COG1742	UPF0060 membrane protein
KSAC_RS06570	COG2326	polyphosphate kinase activity
KSAC_RS06575	COG4221	oxidoreductase activity
KSAC_RS06580	COG1678	Uncharacterized ACR, COG1678
KSAC_RS06590	COG0167	dihydroorotate dehydrogenase activity
KSAC_RS06620	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
KSAC_RS06625	COG1492	cobalamin metabolic process
KSAC_RS06640	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
KSAC_RS06645	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
KSAC_RS06650	COG0406	alpha-ribazole phosphatase activity
KSAC_RS06670	COG1113	amino acid transport
KSAC_RS06680	COG0252	asparaginase activity
KSAC_RS06690	COG2814	Major facilitator Superfamily
KSAC_RS06695	COG3961	Belongs to the TPP enzyme family
KSAC_RS06705	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
KSAC_RS06710	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KSAC_RS06710	COG0574	Belongs to the PEP-utilizing enzyme family
KSAC_RS06730	COG1012	belongs to the aldehyde dehydrogenase family
KSAC_RS06755	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KSAC_RS06765	COG0573	inorganic phosphate transmembrane transporter activity
KSAC_RS06780	COG1902	pentaerythritol trinitrate reductase activity
KSAC_RS06780	COG0446	pyridine nucleotide-disulphide oxidoreductase
KSAC_RS06800	COG1937	Protein conserved in bacteria
KSAC_RS06805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KSAC_RS06830	COG2132	Multicopper oxidase
KSAC_RS06840	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KSAC_RS06855	COG2843	Capsule synthesis protein
KSAC_RS06860	COG2271	Major facilitator Superfamily
KSAC_RS06870	COG1473	amidohydrolase
KSAC_RS06875	COG0583	DNA-binding transcription factor activity
KSAC_RS06885	COG0583	DNA-binding transcription factor activity
KSAC_RS06890	COG2837	iron assimilation
KSAC_RS06910	COG4650	regulator
KSAC_RS06930	COG1012	belongs to the aldehyde dehydrogenase family
KSAC_RS06935	COG2211	Major facilitator Superfamily
KSAC_RS06965	COG0252	asparaginase activity
KSAC_RS06975	COG2985	domain, Protein
KSAC_RS07000	COG0583	DNA-binding transcription factor activity
KSAC_RS07005	COG3048	D-serine ammonia-lyase activity
KSAC_RS07055	COG0778	Nitroreductase
KSAC_RS07060	COG0131	Imidazoleglycerol-phosphate dehydratase
KSAC_RS07070	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KSAC_RS07075	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KSAC_RS07080	COG0107	imidazoleglycerol-phosphate synthase activity
KSAC_RS07085	COG0140	phosphoribosyl-ATP diphosphatase activity
KSAC_RS07095	COG5265	(ABC) transporter
KSAC_RS07100	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KSAC_RS07110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KSAC_RS07115	COG0540	Belongs to the ATCase OTCase family
KSAC_RS07120	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KSAC_RS07125	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KSAC_RS07130	COG0758	DNA mediated transformation
KSAC_RS07135	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KSAC_RS07140	COG0557	exoribonuclease II activity
KSAC_RS07145	COG0793	Belongs to the peptidase S41A family
KSAC_RS07155	COG2885	chlorophyll binding
KSAC_RS07155	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
KSAC_RS07160	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KSAC_RS07165	COG1959	2 iron, 2 sulfur cluster binding
KSAC_RS07180	COG0187	DNA topoisomerase II activity
KSAC_RS07190	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KSAC_RS07200	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KSAC_RS07205	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KSAC_RS07210	COG0196	riboflavin kinase activity
KSAC_RS07215	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
KSAC_RS07220	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
KSAC_RS07225	COG0235	Class ii aldolase
KSAC_RS07230	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KSAC_RS07245	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KSAC_RS07250	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KSAC_RS07270	COG4232	protein-disulfide reductase activity
KSAC_RS07275	COG1643	Atp-dependent helicase
KSAC_RS07310	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KSAC_RS07315	COG0859	PFAM glycosyl transferase family 9
KSAC_RS07325	COG0438	transferase activity, transferring glycosyl groups
KSAC_RS07340	COG0717	Belongs to the dCTP deaminase family
KSAC_RS07345	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KSAC_RS07350	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KSAC_RS07355	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KSAC_RS07360	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KSAC_RS07365	COG0424	maF-like protein
KSAC_RS07370	COG1530	ribonuclease E activity
KSAC_RS07375	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
KSAC_RS07385	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KSAC_RS07390	COG2199	diguanylate cyclase activity
KSAC_RS07390	COG2202	Pas domain
KSAC_RS07390	COG2200	EAL domain
KSAC_RS07415	COG0740	serine-type endopeptidase activity
KSAC_RS07425	COG0436	Aminotransferase
KSAC_RS07465	COG2814	Major facilitator Superfamily
KSAC_RS07470	COG1012	belongs to the aldehyde dehydrogenase family
KSAC_RS07475	COG1252	NADH dehydrogenase
KSAC_RS07480	COG1309	transcriptional regulator
KSAC_RS07490	COG0697	spore germination
KSAC_RS07495	COG1289	transmembrane transporter activity
KSAC_RS07515	COG1846	Transcriptional regulator
KSAC_RS07520	COG2271	Major facilitator Superfamily
KSAC_RS07525	COG3473	Maleate cis-trans isomerase
KSAC_RS07540	COG1538	Outer membrane efflux protein
KSAC_RS07545	COG2249	NAD(P)H dehydrogenase (quinone) activity
KSAC_RS07560	COG0069	glutamate synthase activity
KSAC_RS07565	COG2218	PFAM glutamate synthase alpha subunit domain protein
KSAC_RS07570	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KSAC_RS07580	COG0583	DNA-binding transcription factor activity
KSAC_RS07585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KSAC_RS07595	COG0446	pyridine nucleotide-disulphide oxidoreductase
KSAC_RS07595	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KSAC_RS07610	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KSAC_RS07615	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KSAC_RS07630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KSAC_RS07635	COG1012	belongs to the aldehyde dehydrogenase family
KSAC_RS07650	COG1176	ABC-type spermidine putrescine transport system, permease component I
KSAC_RS07655	COG0395	ABC-type sugar transport system, permease component
KSAC_RS07660	COG3842	ATPase activity
KSAC_RS07670	COG1522	sequence-specific DNA binding
KSAC_RS07685	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
KSAC_RS07685	COG3408	Glycogen debranching enzyme
KSAC_RS07690	COG2211	Major facilitator Superfamily
KSAC_RS07695	COG0697	spore germination
KSAC_RS07710	COG1917	Cupin 2, conserved barrel domain protein
KSAC_RS07725	COG3971	2-oxopent-4-enoate hydratase activity
KSAC_RS07745	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
KSAC_RS07755	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KSAC_RS07805	COG2368	4-hydroxyphenylacetate
KSAC_RS07810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KSAC_RS07820	COG0010	Belongs to the arginase family
KSAC_RS07825	COG2176	DNA-directed DNA polymerase activity
KSAC_RS07840	COG1132	(ABC) transporter
KSAC_RS07850	COG1321	iron dependent repressor
KSAC_RS07860	COG0450	alkyl hydroperoxide reductase
KSAC_RS07880	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KSAC_RS07910	COG0352	thiamine-phosphate diphosphorylase activity
KSAC_RS07910	COG0351	phosphomethylpyrimidine kinase
KSAC_RS07915	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KSAC_RS07920	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KSAC_RS07930	COG0037	tRNA processing
KSAC_RS07940	COG2885	chlorophyll binding
KSAC_RS07945	COG0823	Involved in the tonB-independent uptake of proteins
KSAC_RS07955	COG0848	biopolymer transport protein
KSAC_RS07965	COG0824	Thioesterase
KSAC_RS07970	COG2255	four-way junction helicase activity
KSAC_RS07975	COG0632	four-way junction helicase activity
KSAC_RS07980	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
KSAC_RS07985	COG0217	transcriptional regulatory protein
KSAC_RS07990	COG0653	protein targeting
KSAC_RS07995	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KSAC_RS08000	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KSAC_RS08005	COG1714	RDD family
KSAC_RS08010	COG0668	transmembrane transport
KSAC_RS08025	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KSAC_RS08030	COG1127	ABC transporter
KSAC_RS08060	COG2967	ApaG domain
KSAC_RS08065	COG0302	gtp cyclohydrolase
KSAC_RS08075	COG0521	Mo-molybdopterin cofactor biosynthetic process
KSAC_RS08100	COG3961	Belongs to the TPP enzyme family
KSAC_RS08105	COG0277	FAD linked oxidase domain protein
KSAC_RS08130	COG0484	heat shock protein binding
KSAC_RS08140	COG0025	NhaP-type Na H and K H
KSAC_RS08150	COG0667	Aldo Keto reductase
KSAC_RS08190	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KSAC_RS08200	COG1573	uracil-dna glycosylase
KSAC_RS08210	COG1253	flavin adenine dinucleotide binding
KSAC_RS08215	COG0535	radical SAM domain protein
KSAC_RS08220	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KSAC_RS08240	COG3394	polysaccharide catabolic process
KSAC_RS08245	COG3118	belongs to the thioredoxin family
KSAC_RS08250	COG1074	ATP-dependent DNA helicase activity
KSAC_RS08260	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KSAC_RS08270	COG0492	ferredoxin-NADP+ reductase activity
KSAC_RS08275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KSAC_RS08285	COG1217	gtp-binding protein TYPA
KSAC_RS08290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KSAC_RS08305	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
KSAC_RS08310	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KSAC_RS08315	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KSAC_RS08320	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KSAC_RS08325	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KSAC_RS08330	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KSAC_RS08335	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KSAC_RS08355	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KSAC_RS08370	COG3008	intermembrane lipid transfer
KSAC_RS08375	COG2995	paraquat-inducible protein a
KSAC_RS08385	COG2610	gluconate transmembrane transporter activity
KSAC_RS08395	COG0842	Transport permease protein
KSAC_RS08400	COG0842	Transport permease protein
KSAC_RS08400	COG1129	ABC transporter
KSAC_RS08405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KSAC_RS08415	COG1289	transmembrane transporter activity
KSAC_RS08450	COG0347	Belongs to the P(II) protein family
KSAC_RS08455	COG0004	ammonium transporteR
KSAC_RS08485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KSAC_RS08500	COG2202	Pas domain
KSAC_RS08500	COG2200	EAL domain
KSAC_RS08500	COG2199	diguanylate cyclase activity
KSAC_RS08530	COG0656	L-ascorbic acid biosynthetic process
KSAC_RS08540	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KSAC_RS08565	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KSAC_RS08570	COG2835	tetraacyldisaccharide 4'-kinase activity
KSAC_RS08575	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KSAC_RS08580	COG1648	precorrin-2 dehydrogenase activity
KSAC_RS08580	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KSAC_RS08630	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
KSAC_RS08650	COG2610	gluconate transmembrane transporter activity
KSAC_RS08725	COG2194	sulfuric ester hydrolase activity
KSAC_RS08730	COG0538	isocitrate dehydrogenase activity
KSAC_RS08740	COG0586	Pfam SNARE associated Golgi protein
KSAC_RS08745	COG0778	Nitroreductase
KSAC_RS08770	COG1028	Short-chain dehydrogenase reductase Sdr
KSAC_RS08775	COG0251	oxidation-reduction process
KSAC_RS08780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KSAC_RS08795	COG2200	EAL domain
KSAC_RS08795	COG2202	Pas domain
KSAC_RS08795	COG2199	diguanylate cyclase activity
KSAC_RS08805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KSAC_RS08820	COG0242	peptide deformylase activity
KSAC_RS08825	COG0745	RESPONSE REGULATOR receiver
KSAC_RS08840	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KSAC_RS08855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KSAC_RS08860	COG0671	phosphoesterase, PA-phosphatase related
KSAC_RS08875	COG2948	multi-organism process
KSAC_RS08905	COG0723	plastoquinol--plastocyanin reductase activity
KSAC_RS08915	COG2999	glutathione oxidoreductase activity
KSAC_RS08935	COG1028	Short-chain dehydrogenase reductase Sdr
KSAC_RS08950	COG0114	fumarate hydratase activity
KSAC_RS08955	COG1280	lysine exporter protein (LysE YggA)
KSAC_RS08965	COG1121	(ABC) transporter
KSAC_RS08975	COG0803	Belongs to the bacterial solute-binding protein 9 family
KSAC_RS08990	COG0747	negative chemotaxis
KSAC_RS08995	COG1999	signal sequence binding
KSAC_RS09000	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KSAC_RS09000	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KSAC_RS09020	COG3025	triphosphatase activity
KSAC_RS09025	COG5001	Diguanylate cyclase
KSAC_RS09060	COG0542	response to heat
KSAC_RS09065	COG0667	Aldo Keto reductase
KSAC_RS09070	COG0583	DNA-binding transcription factor activity
KSAC_RS09080	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KSAC_RS09090	COG0028	Belongs to the TPP enzyme family
KSAC_RS09095	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KSAC_RS09100	COG0560	Phosphoserine phosphatase
KSAC_RS09100	COG3830	Belongs to the UPF0237 family
KSAC_RS09110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KSAC_RS09125	COG2983	Belongs to the UPF0260 family
KSAC_RS09140	COG3842	ATPase activity
KSAC_RS09165	COG1566	PFAM secretion protein HlyD family protein
KSAC_RS09195	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KSAC_RS09200	COG1127	ABC transporter
KSAC_RS09230	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KSAC_RS09235	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KSAC_RS09235	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KSAC_RS09250	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KSAC_RS09275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KSAC_RS09290	COG0469	pyruvate kinase activity
KSAC_RS09295	COG0287	Prephenate dehydrogenase
KSAC_RS09305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KSAC_RS09310	COG1215	transferase activity, transferring glycosyl groups
KSAC_RS09315	COG1562	ergosterol biosynthetic process
KSAC_RS09320	COG1562	ergosterol biosynthetic process
KSAC_RS09325	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KSAC_RS09330	COG1657	PFAM Prenyltransferase squalene oxidase
KSAC_RS09340	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KSAC_RS09345	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
KSAC_RS09365	COG2814	Major facilitator Superfamily
KSAC_RS09370	COG0194	GDP metabolic process
KSAC_RS09375	COG0300	oxidoreductase activity
KSAC_RS09395	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KSAC_RS09415	COG0673	inositol 2-dehydrogenase activity
KSAC_RS09420	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KSAC_RS09425	COG1215	transferase activity, transferring glycosyl groups
KSAC_RS09430	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KSAC_RS09435	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KSAC_RS09440	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KSAC_RS09445	COG0356	it plays a direct role in the translocation of protons across the membrane
KSAC_RS09460	COG0138	bifunctional purine biosynthesis protein purh
KSAC_RS09475	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KSAC_RS09475	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KSAC_RS09490	COG1660	Displays ATPase and GTPase activities
KSAC_RS09495	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
KSAC_RS09520	COG1981	membrane
KSAC_RS09525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KSAC_RS09530	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KSAC_RS09535	COG0424	maF-like protein
KSAC_RS09550	COG1091	dTDP-4-dehydrorhamnose reductase activity
KSAC_RS09570	COG2086	electron transfer activity
KSAC_RS09585	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KSAC_RS09590	COG3047	cAMP biosynthetic process
KSAC_RS09600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KSAC_RS09605	COG0628	permease
KSAC_RS09615	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KSAC_RS09620	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
KSAC_RS09630	COG0535	radical SAM domain protein
KSAC_RS09635	COG2205	protein histidine kinase activity
KSAC_RS09640	COG0745	RESPONSE REGULATOR receiver
KSAC_RS09645	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KSAC_RS09650	COG0443	Heat shock 70 kDa protein
KSAC_RS09655	COG0484	heat shock protein binding
KSAC_RS09660	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KSAC_RS09665	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KSAC_RS09670	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KSAC_RS09675	COG1028	Short-chain dehydrogenase reductase Sdr
KSAC_RS09690	COG2814	Major facilitator Superfamily
KSAC_RS09695	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
KSAC_RS09700	COG1024	Enoyl-CoA hydratase
KSAC_RS09705	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KSAC_RS09715	COG0735	belongs to the Fur family
KSAC_RS09725	COG2814	Major facilitator Superfamily
KSAC_RS09730	COG0285	dihydrofolate synthase activity
KSAC_RS09735	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KSAC_RS09740	COG0159	tryptophan synthase activity
KSAC_RS09745	COG0133	tryptophan synthase activity
KSAC_RS09755	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KSAC_RS09770	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KSAC_RS09775	COG0445	tRNA wobble uridine modification
KSAC_RS09780	COG0357	Ribosomal RNA small subunit methyltransferase G
KSAC_RS09800	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
KSAC_RS09805	COG1187	pseudouridine synthase activity
KSAC_RS09810	COG0742	ribosomal rna small subunit methyltransferase
KSAC_RS09815	COG1674	ftsk spoiiie
KSAC_RS09835	COG0590	tRNA wobble adenosine to inosine editing
KSAC_RS09840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KSAC_RS09845	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KSAC_RS09900	COG0312	modulator of DNA gyrase
KSAC_RS09905	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
KSAC_RS09910	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
KSAC_RS09930	COG0284	orotidine-5'-phosphate decarboxylase activity
KSAC_RS09935	COG0135	phosphoribosylanthranilate isomerase activity
KSAC_RS09955	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KSAC_RS09970	COG1612	heme a metabolic process
KSAC_RS09980	COG2814	Major facilitator Superfamily
KSAC_RS09985	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KSAC_RS09990	COG1289	transmembrane transporter activity
KSAC_RS09995	COG0439	Biotin carboxylase
KSAC_RS10000	COG0511	ligase activity, forming carbon-carbon bonds
KSAC_RS10010	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KSAC_RS10015	COG1295	ribonuclease BN
KSAC_RS10020	COG0019	diaminopimelate decarboxylase activity
KSAC_RS10030	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KSAC_RS10035	COG4133	protoheme IX ABC transporter activity
KSAC_RS10040	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KSAC_RS10045	COG0583	DNA-binding transcription factor activity
KSAC_RS10055	COG0542	response to heat
KSAC_RS10065	COG0779	Required for maturation of 30S ribosomal subunits
KSAC_RS10080	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KSAC_RS10080	COG5373	membrane
KSAC_RS10085	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KSAC_RS10095	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KSAC_RS10100	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KSAC_RS10105	COG1185	polyribonucleotide nucleotidyltransferase activity
KSAC_RS10115	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KSAC_RS10120	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KSAC_RS10125	COG1420	regulation of RNA biosynthetic process
KSAC_RS10130	COG0667	Aldo Keto reductase
KSAC_RS10135	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KSAC_RS10175	COG0778	Nitroreductase
KSAC_RS10210	COG0815	Transfers the fatty acyl group on membrane lipoproteins
KSAC_RS10215	COG1396	sequence-specific DNA binding
KSAC_RS10225	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KSAC_RS10230	COG1053	succinate dehydrogenase
KSAC_RS10245	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KSAC_RS10250	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KSAC_RS10270	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KSAC_RS10275	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
KSAC_RS10285	COG0508	dehydrogenase complex catalyzes the overall conversion of
KSAC_RS10290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KSAC_RS10295	COG5001	Diguanylate cyclase
KSAC_RS10295	COG1716	ATPase activity
KSAC_RS10300	COG2202	Pas domain
KSAC_RS10300	COG2199	diguanylate cyclase activity
KSAC_RS10300	COG2200	EAL domain
KSAC_RS10310	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KSAC_RS10310	COG1918	ferrous iron import across plasma membrane
KSAC_RS10320	COG1797	cobyrinic acid a,c-diamide synthase activity
KSAC_RS10325	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
KSAC_RS10345	COG2099	Precorrin-6x reductase
KSAC_RS10395	COG0604	alcohol dehydrogenase
KSAC_RS10400	COG0778	Nitroreductase
KSAC_RS10405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KSAC_RS10410	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KSAC_RS10420	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KSAC_RS10425	COG4974	Belongs to the 'phage' integrase family
KSAC_RS10435	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KSAC_RS10475	COG2814	Major facilitator Superfamily
KSAC_RS10485	COG1570	exodeoxyribonuclease VII activity
KSAC_RS10505	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KSAC_RS10510	COG1028	Short-chain dehydrogenase reductase Sdr
KSAC_RS10515	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KSAC_RS10525	COG0140	phosphoribosyl-ATP diphosphatase activity
KSAC_RS10570	COG1368	sulfuric ester hydrolase activity
KSAC_RS10715	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KSAC_RS10715	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
KSAC_RS10735	COG1410	methionine synthase
KSAC_RS10735	COG0646	methionine synthase
KSAC_RS10775	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KSAC_RS10785	COG0488	(ABC) transporter
KSAC_RS10800	COG2853	Lipoprotein
KSAC_RS10805	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
KSAC_RS10835	COG1881	PFAM PEBP family protein
KSAC_RS10845	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KSAC_RS10850	COG0343	queuine tRNA-ribosyltransferase activity
KSAC_RS10855	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KSAC_RS10865	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
KSAC_RS10870	COG0489	protein tyrosine kinase activity
KSAC_RS10880	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KSAC_RS10890	COG0246	Mannitol dehydrogenase
KSAC_RS10905	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
KSAC_RS10910	COG2943	transferase activity, transferring hexosyl groups
KSAC_RS10920	COG2814	Major facilitator Superfamily
KSAC_RS10930	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KSAC_RS10950	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KSAC_RS10955	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
KSAC_RS10960	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KSAC_RS10965	COG0561	phosphatase activity
KSAC_RS10975	COG0363	glucosamine-6-phosphate deaminase activity
KSAC_RS10980	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KSAC_RS10985	COG3265	gluconokinase activity
KSAC_RS10990	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KSAC_RS10995	COG3001	Fructosamine kinase
KSAC_RS11000	COG1902	pentaerythritol trinitrate reductase activity
KSAC_RS11010	COG0583	DNA-binding transcription factor activity
KSAC_RS11015	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KSAC_RS11040	COG0483	inositol monophosphate 1-phosphatase activity
KSAC_RS11045	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KSAC_RS11055	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
KSAC_RS11060	COG0352	thiamine-phosphate diphosphorylase activity
KSAC_RS11085	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KSAC_RS11090	COG1692	metallophosphoesterase
KSAC_RS11095	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KSAC_RS11105	COG0596	Alpha beta hydrolase
KSAC_RS11110	COG3321	synthase
KSAC_RS11110	COG1028	Short-chain dehydrogenase reductase Sdr
KSAC_RS11110	COG0604	alcohol dehydrogenase
KSAC_RS11125	COG0436	Aminotransferase
KSAC_RS11145	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KSAC_RS11180	COG0129	dihydroxy-acid dehydratase activity
KSAC_RS11205	COG4221	oxidoreductase activity
KSAC_RS11215	COG0481	GTPase activity
KSAC_RS11260	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KSAC_RS11300	COG5487	UPF0391 membrane protein
KSAC_RS11315	COG0776	regulation of translation
KSAC_RS11330	COG0247	lactate metabolic process
KSAC_RS11350	COG2308	Evidence 4 Homologs of previously reported genes of
KSAC_RS11390	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KSAC_RS11400	COG1496	oxidoreductase activity
KSAC_RS11410	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KSAC_RS11415	COG0406	alpha-ribazole phosphatase activity
KSAC_RS11420	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KSAC_RS11425	COG0193	aminoacyl-tRNA hydrolase activity
KSAC_RS11430	COG0012	GTP binding
KSAC_RS11435	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KSAC_RS11440	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KSAC_RS11445	COG0799	negative regulation of ribosome biogenesis
KSAC_RS11450	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KSAC_RS11460	COG0251	oxidation-reduction process
KSAC_RS11480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KSAC_RS11530	COG0583	DNA-binding transcription factor activity
KSAC_RS11535	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
KSAC_RS11545	COG1811	Na channel or pump
KSAC_RS11565	COG1309	transcriptional regulator
KSAC_RS11580	COG1028	Short-chain dehydrogenase reductase Sdr
KSAC_RS11585	COG2207	Transcriptional regulator
KSAC_RS11635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KSAC_RS11675	COG0662	Cupin 2, conserved barrel domain protein
KSAC_RS11675	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
KSAC_RS11680	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KSAC_RS11710	COG0495	leucyl-tRNA aminoacylation
KSAC_RS11720	COG1472	Belongs to the glycosyl hydrolase 3 family
KSAC_RS11740	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KSAC_RS11745	COG3158	transport of potassium into the cell
KSAC_RS11750	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KSAC_RS11760	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KSAC_RS11780	COG2309	aminopeptidase activity
KSAC_RS11795	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KSAC_RS11800	COG2945	thiolester hydrolase activity
KSAC_RS11820	COG0482	sulfurtransferase activity
KSAC_RS11835	COG0523	cobalamin synthesis protein
KSAC_RS11855	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KSAC_RS11865	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
KSAC_RS11870	COG2189	Belongs to the N(4) N(6)-methyltransferase family
KSAC_RS11880	COG4974	Belongs to the 'phage' integrase family
KSAC_RS11900	COG0347	Belongs to the P(II) protein family
KSAC_RS11905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KSAC_RS11925	COG1530	ribonuclease E activity
KSAC_RS11940	COG0860	N-Acetylmuramoyl-L-alanine amidase
KSAC_RS11945	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KSAC_RS11970	COG0768	penicillin binding
KSAC_RS11975	COG0772	Belongs to the SEDS family
KSAC_RS11990	COG0752	glycyl-tRNA synthetase alpha subunit
KSAC_RS11995	COG3416	Protein conserved in bacteria
KSAC_RS12005	COG0800	Aldolase
KSAC_RS12010	COG0129	dihydroxy-acid dehydratase activity
KSAC_RS12025	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KSAC_RS12030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KSAC_RS12035	COG0629	single-stranded DNA binding
KSAC_RS12045	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KSAC_RS12050	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KSAC_RS12060	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KSAC_RS12065	COG0509	glycine decarboxylation via glycine cleavage system
KSAC_RS12070	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KSAC_RS12070	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KSAC_RS12085	COG1120	ATPase activity
KSAC_RS12110	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KSAC_RS12115	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KSAC_RS12120	COG0552	protein localization to endoplasmic reticulum
KSAC_RS12130	COG0126	phosphoglycerate kinase activity
KSAC_RS12150	COG0156	8-amino-7-oxononanoate synthase activity
KSAC_RS12160	COG0405	Gamma-glutamyltransferase
KSAC_RS12180	COG1072	(Pantothenic acid kinase))
KSAC_RS12185	COG1012	belongs to the aldehyde dehydrogenase family
KSAC_RS12195	COG1802	Transcriptional regulator
KSAC_RS12200	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
KSAC_RS12210	COG0850	regulation of cytokinetic process
KSAC_RS12220	COG2081	HI0933 family
KSAC_RS12230	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KSAC_RS12235	COG0564	pseudouridine synthase activity
KSAC_RS12250	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KSAC_RS12250	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KSAC_RS12265	COG3852	Histidine kinase
KSAC_RS12280	COG2204	response regulator
KSAC_RS12285	COG1923	regulation of RNA biosynthetic process
KSAC_RS12290	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KSAC_RS12295	COG0483	inositol monophosphate 1-phosphatase activity
KSAC_RS12300	COG3956	TIGRFAM MazG family protein
KSAC_RS12320	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
KSAC_RS12325	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KSAC_RS12335	COG0564	pseudouridine synthase activity
KSAC_RS12400	COG1051	belongs to the nudix hydrolase family
KSAC_RS12405	COG0326	Molecular chaperone. Has ATPase activity
KSAC_RS12410	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
KSAC_RS12415	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KSAC_RS12425	COG0708	Exodeoxyribonuclease III
KSAC_RS12430	COG0316	Belongs to the HesB IscA family
KSAC_RS12435	COG0232	Belongs to the dGTPase family. Type 2 subfamily
KSAC_RS12440	COG0018	arginyl-trna synthetase
KSAC_RS12450	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KSAC_RS12455	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KSAC_RS12465	COG0805	protein transport
KSAC_RS12470	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KSAC_RS12495	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
KSAC_RS12510	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KSAC_RS12520	COG0215	cysteine-tRNA ligase activity
KSAC_RS12525	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KSAC_RS12530	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KSAC_RS12565	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KSAC_RS12570	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KSAC_RS12580	COG2885	chlorophyll binding
KSAC_RS12580	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
KSAC_RS12585	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
KSAC_RS12585	COG2885	chlorophyll binding
KSAC_RS12595	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KSAC_RS12605	COG4974	Belongs to the 'phage' integrase family
KSAC_RS12610	COG0825	malonyl-CoA metabolic process
KSAC_RS12615	COG1058	Belongs to the CinA family
KSAC_RS12615	COG1546	Belongs to the CinA family
KSAC_RS12640	COG1862	Preprotein translocase
KSAC_RS12645	COG2814	Major facilitator Superfamily
KSAC_RS12690	COG1758	RNA polymerase activity
KSAC_RS12700	COG0736	holo-[acyl-carrier-protein] synthase activity
KSAC_RS12705	COG0681	Belongs to the peptidase S26 family
KSAC_RS12715	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KSAC_RS12720	COG0528	UMP kinase activity
KSAC_RS12725	COG0233	cytoplasmic translational termination
KSAC_RS12730	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KSAC_RS12740	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KSAC_RS12745	COG0750	zinc metalloprotease
KSAC_RS12750	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KSAC_RS12760	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KSAC_RS12765	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KSAC_RS12770	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KSAC_RS12775	COG3494	Protein of unknown function (DUF1009)
KSAC_RS12780	COG0346	lactoylglutathione lyase activity
KSAC_RS12790	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KSAC_RS12795	COG0594	ribonuclease P activity
KSAC_RS12800	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KSAC_RS12805	COG0706	membrane insertase activity
KSAC_RS12810	COG0218	Necessary for normal cell division and for the maintenance of normal septation
KSAC_RS12815	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KSAC_RS12820	COG2171	N-acyltransferase activity
KSAC_RS12825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KSAC_RS12840	COG0101	tRNA pseudouridine synthase activity
KSAC_RS12845	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KSAC_RS12850	COG0242	peptide deformylase activity
KSAC_RS12865	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KSAC_RS12870	COG1137	ATPase activity
KSAC_RS12920	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KSAC_RS12925	COG0556	nucleotide-excision repair
KSAC_RS12940	COG0189	ligase activity
KSAC_RS12955	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KSAC_RS12960	COG0109	protoheme IX farnesyltransferase activity
KSAC_RS12975	COG0312	modulator of DNA gyrase
KSAC_RS12980	COG0612	Peptidase, M16
KSAC_RS12995	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
KSAC_RS13005	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
KSAC_RS13010	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KSAC_RS13015	COG0728	peptidoglycan biosynthetic process
KSAC_RS13020	COG0386	Belongs to the glutathione peroxidase family
KSAC_RS13025	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KSAC_RS13030	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KSAC_RS13035	COG0181	hydroxymethylbilane synthase activity
KSAC_RS13045	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
KSAC_RS13060	COG2189	Belongs to the N(4) N(6)-methyltransferase family
KSAC_RS13065	COG1858	cytochrome C peroxidase
KSAC_RS13080	COG0408	coproporphyrinogen oxidase activity
KSAC_RS13085	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KSAC_RS13085	COG2857	Cytochrome c1
KSAC_RS13090	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KSAC_RS13095	COG0412	Dienelactone hydrolase
KSAC_RS13100	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KSAC_RS13105	COG0459	protein refolding
KSAC_RS13110	COG1278	Cold shock
KSAC_RS13115	COG1199	ATP-dependent helicase activity
KSAC_RS13130	COG2095	MarC family integral membrane protein
KSAC_RS13135	COG1573	uracil-dna glycosylase
KSAC_RS13160	COG0670	Belongs to the BI1 family
KSAC_RS13180	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KSAC_RS13200	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KSAC_RS13215	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KSAC_RS13220	COG1086	Polysaccharide biosynthesis protein
KSAC_RS13245	COG2814	Major facilitator Superfamily
KSAC_RS13250	COG0488	(ABC) transporter
KSAC_RS13255	COG0105	UTP biosynthetic process
KSAC_RS13260	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KSAC_RS13265	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KSAC_RS13275	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KSAC_RS13290	COG2080	2 iron, 2 sulfur cluster binding
KSAC_RS13295	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KSAC_RS13305	COG0583	DNA-binding transcription factor activity
KSAC_RS13310	COG2072	flavoprotein involved in K transport
KSAC_RS13335	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KSAC_RS13350	COG2351	hydroxyisourate hydrolase activity
KSAC_RS13355	COG0473	3-isopropylmalate dehydrogenase activity
KSAC_RS13360	COG0006	proline dipeptidase activity
KSAC_RS13370	COG2264	protein methyltransferase activity
KSAC_RS13375	COG0210	DNA helicase
KSAC_RS13380	COG2003	Belongs to the UPF0758 family
KSAC_RS13390	COG2003	Belongs to the UPF0758 family
KSAC_RS13395	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KSAC_RS13400	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KSAC_RS13420	COG0071	Belongs to the small heat shock protein (HSP20) family
KSAC_RS13425	COG0254	rRNA binding
KSAC_RS13430	COG1970	mechanosensitive ion channel activity
KSAC_RS13445	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KSAC_RS13460	COG0488	(ABC) transporter
KSAC_RS13465	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
KSAC_RS13470	COG0784	Response regulator, receiver
KSAC_RS13495	COG4988	ABC transporter
KSAC_RS13500	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KSAC_RS13510	COG0514	ATP-dependent DNA helicase (RecQ)
KSAC_RS13515	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KSAC_RS13520	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KSAC_RS13525	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KSAC_RS13540	COG0837	glucose binding
KSAC_RS13625	COG0587	DNA-directed DNA polymerase activity
KSAC_RS13690	COG3328	transposase activity
KSAC_RS13720	COG0789	Transcriptional regulator
KSAC_RS13730	COG5489	Protein of unknown function (DUF736)
KSAC_RS13780	COG1196	nuclear chromosome segregation
KSAC_RS13780	COG0741	lytic transglycosylase activity
KSAC_RS13780	COG0739	heme binding
KSAC_RS13805	COG0848	biopolymer transport protein
KSAC_RS13855	COG2271	Major facilitator Superfamily
KSAC_RS13860	COG0697	spore germination
KSAC_RS13865	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
KSAC_RS13870	COG1984	allophanate hydrolase subunit 2
KSAC_RS13880	COG4221	oxidoreductase activity
KSAC_RS13885	COG0511	ligase activity, forming carbon-carbon bonds
KSAC_RS13900	COG0436	Aminotransferase
KSAC_RS13905	COG1027	Aspartate ammonia-lyase
KSAC_RS13930	COG1012	belongs to the aldehyde dehydrogenase family
KSAC_RS13940	COG1028	Short-chain dehydrogenase reductase Sdr
KSAC_RS13975	COG1172	Belongs to the binding-protein-dependent transport system permease family
KSAC_RS13980	COG1129	ABC transporter
KSAC_RS13985	COG1172	Belongs to the binding-protein-dependent transport system permease family
KSAC_RS13990	COG1063	alcohol dehydrogenase
KSAC_RS13995	COG1309	transcriptional regulator
KSAC_RS14010	COG3237	CsbD-like
KSAC_RS14020	COG2353	YceI-like domain
KSAC_RS14025	COG1309	transcriptional regulator
KSAC_RS14035	COG3938	Belongs to the proline racemase family
KSAC_RS14055	COG0765	amino acid transport
KSAC_RS14065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KSAC_RS14070	COG4948	Mandelate Racemase Muconate Lactonizing
KSAC_RS14075	COG0006	proline dipeptidase activity
KSAC_RS14080	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KSAC_RS14085	COG0504	CTP synthase activity
KSAC_RS14090	COG1028	Short-chain dehydrogenase reductase Sdr
KSAC_RS14095	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KSAC_RS14100	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
KSAC_RS14105	COG3284	Transcriptional regulator
KSAC_RS14110	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KSAC_RS14115	COG0022	dehydrogenase e1 component
KSAC_RS14125	COG1070	Carbohydrate kinase
KSAC_RS14135	COG2814	Major facilitator Superfamily
KSAC_RS14140	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KSAC_RS14150	COG0506	proline dehydrogenase activity
KSAC_RS14150	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
KSAC_RS14150	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
KSAC_RS14165	COG5564	TIM-barrel signal transduction protein
KSAC_RS14185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KSAC_RS14195	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KSAC_RS14200	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KSAC_RS14215	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KSAC_RS14225	COG0525	valine-tRNA ligase activity
KSAC_RS14230	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KSAC_RS14235	COG1116	anion transmembrane transporter activity
KSAC_RS14240	COG0395	ABC-type sugar transport system, permease component
KSAC_RS14245	COG0756	dUTP diphosphatase activity
KSAC_RS14255	COG2226	methyltransferase
KSAC_RS14260	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KSAC_RS14265	COG0268	Binds directly to 16S ribosomal RNA
KSAC_RS14275	COG0840	transmembrane signaling receptor activity
KSAC_RS14300	COG1464	Belongs to the NlpA lipoprotein family
KSAC_RS14310	COG2011	ABC-type metal ion transport system permease component
KSAC_RS14320	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
KSAC_RS14325	COG4208	sulfate ABC transporter
KSAC_RS14330	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
KSAC_RS14335	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
KSAC_RS14345	COG1012	belongs to the aldehyde dehydrogenase family
KSAC_RS14350	COG1271	oxidase subunit
KSAC_RS14355	COG1294	oxidase, subunit
KSAC_RS14365	COG1309	transcriptional regulator
KSAC_RS14395	COG1028	Short-chain dehydrogenase reductase Sdr
KSAC_RS14405	COG1028	Short-chain dehydrogenase reductase Sdr
KSAC_RS14415	COG1012	belongs to the aldehyde dehydrogenase family
KSAC_RS14435	COG1408	metallophosphoesterase
KSAC_RS14450	COG1595	DNA-templated transcription, initiation
KSAC_RS14460	COG4774	siderophore transport
KSAC_RS14465	COG1063	alcohol dehydrogenase
KSAC_RS14480	COG0671	phosphoesterase, PA-phosphatase related
KSAC_RS14490	COG3800	Transcriptional regulator
KSAC_RS14490	COG1396	sequence-specific DNA binding
KSAC_RS14515	COG3104	oligopeptide transport
KSAC_RS14530	COG0415	Belongs to the DNA photolyase family
KSAC_RS14540	COG1012	belongs to the aldehyde dehydrogenase family
KSAC_RS14545	COG1979	alcohol dehydrogenase
KSAC_RS14550	COG1309	transcriptional regulator
KSAC_RS14575	COG1597	lipid kinase activity
KSAC_RS14585	COG1192	Involved in chromosome partitioning
KSAC_RS14615	COG2814	Major facilitator Superfamily
KSAC_RS14620	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KSAC_RS14625	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KSAC_RS14630	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KSAC_RS14630	COG0649	NAD binding
KSAC_RS14650	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KSAC_RS14655	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KSAC_RS14660	COG0839	Belongs to the complex I subunit 6 family
KSAC_RS14665	COG0713	ATP synthesis coupled electron transport
KSAC_RS14670	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KSAC_RS14680	COG1007	ATP synthesis coupled electron transport
KSAC_RS14685	COG0517	IMP dehydrogenase activity
KSAC_RS14685	COG0516	GMP reductase activity
KSAC_RS14700	COG0517	IMP dehydrogenase activity
KSAC_RS14710	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KSAC_RS14730	COG3831	ATPase activity
KSAC_RS14755	COG0457	Tetratricopeptide repeat
KSAC_RS14760	COG1607	acyl-coa hydrolase
KSAC_RS14780	COG1012	belongs to the aldehyde dehydrogenase family
KSAC_RS14790	COG1028	Short-chain dehydrogenase reductase Sdr
KSAC_RS14795	COG0488	(ABC) transporter
KSAC_RS14805	COG2070	2-Nitropropane dioxygenase
KSAC_RS14810	COG1192	Involved in chromosome partitioning
KSAC_RS14825	COG1271	oxidase subunit
KSAC_RS14830	COG1294	oxidase, subunit
KSAC_RS14845	COG0243	molybdopterin cofactor binding
KSAC_RS14860	COG0314	molybdopterin synthase activity
KSAC_RS14865	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KSAC_RS14875	COG0840	transmembrane signaling receptor activity
KSAC_RS14895	COG3585	molybdate ion transport
KSAC_RS14900	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
KSAC_RS14915	COG1126	abc transporter atp-binding protein
KSAC_RS14935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KSAC_RS14955	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KSAC_RS14995	COG1215	transferase activity, transferring glycosyl groups
KSAC_RS15000	COG1285	pathogenesis
KSAC_RS15020	COG4774	siderophore transport
KSAC_RS15040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KSAC_RS15055	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KSAC_RS15070	COG0840	transmembrane signaling receptor activity
KSAC_RS15100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KSAC_RS15130	COG1028	Short-chain dehydrogenase reductase Sdr
KSAC_RS15140	COG3459	Glycosyltransferase 36 associated
KSAC_RS15145	COG1956	GAF domain-containing protein
KSAC_RS15150	COG1253	flavin adenine dinucleotide binding
KSAC_RS15155	COG0306	phosphate transporter
KSAC_RS15250	COG2805	Type II/IV secretion system protein
KSAC_RS15295	COG4372	Transposase
KSAC_RS15315	COG4974	Belongs to the 'phage' integrase family
KSAC_RS15385	COG4974	Belongs to the 'phage' integrase family
KSAC_RS15390	COG0517	IMP dehydrogenase activity
KSAC_RS15415	COG1671	Belongs to the UPF0178 family
KSAC_RS15425	COG3750	Belongs to the UPF0335 family
KSAC_RS15440	COG3437	response regulator, receiver
KSAC_RS15450	COG0210	DNA helicase
KSAC_RS15520	COG1475	DNA binding
KSAC_RS15545	COG1192	Involved in chromosome partitioning
KSAC_RS15610	COG3328	transposase activity
KSAC_RS15620	COG3177	Filamentation induced by cAMP protein fic
KSAC_RS15625	COG4974	Belongs to the 'phage' integrase family
KSAC_RS15655	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
KSAC_RS15665	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
KSAC_RS15735	COG2233	PERMEase
KSAC_RS15740	COG0402	S-adenosylhomocysteine deaminase activity
KSAC_RS15765	COG2267	carboxylic ester hydrolase activity
KSAC_RS15770	COG0583	DNA-binding transcription factor activity
KSAC_RS15775	COG2072	flavoprotein involved in K transport
KSAC_RS15785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KSAC_RS15795	COG0444	Belongs to the ABC transporter superfamily
KSAC_RS15800	COG4608	Belongs to the ABC transporter superfamily
KSAC_RS15805	COG0747	negative chemotaxis
KSAC_RS15835	COG2175	clavaminate synthase activity
KSAC_RS15840	COG1113	amino acid transport
KSAC_RS15875	COG0587	DNA-directed DNA polymerase activity
KSAC_RS15955	COG0583	DNA-binding transcription factor activity
KSAC_RS15960	COG3119	arylsulfatase activity
KSAC_RS15995	COG4974	Belongs to the 'phage' integrase family
KSAC_RS16005	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
KSAC_RS16065	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KSAC_RS16085	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KSAC_RS16130	COG4786	Flagellar basal body rod
KSAC_RS16135	COG4786	Flagellar basal body rod
KSAC_RS16145	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
KSAC_RS16150	COG1338	Plays a role in the flagellum-specific transport system
KSAC_RS16155	COG3190	flagellar
KSAC_RS16160	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KSAC_RS16170	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KSAC_RS16175	COG1766	The M ring may be actively involved in energy transduction
KSAC_RS16195	COG0673	inositol 2-dehydrogenase activity
KSAC_RS16220	COG1215	transferase activity, transferring glycosyl groups
KSAC_RS16230	COG0438	transferase activity, transferring glycosyl groups
KSAC_RS16235	COG1596	polysaccharide export
KSAC_RS16255	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
KSAC_RS16265	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KSAC_RS16275	COG1987	bacterial-type flagellum assembly
KSAC_RS16280	COG1677	Flagellar hook-basal body complex protein FliE
KSAC_RS16290	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KSAC_RS16295	COG1558	bacterial-type flagellum-dependent cell motility
KSAC_RS16300	COG1815	bacterial-type flagellum-dependent cell motility
KSAC_RS16310	COG1216	Glycosyl transferase, family 2
KSAC_RS16310	COG1442	glycosyl transferase family 8
KSAC_RS16340	COG0840	transmembrane signaling receptor activity
KSAC_RS16350	COG4974	Belongs to the 'phage' integrase family
KSAC_RS16360	COG1475	DNA binding
KSAC_RS16365	COG1192	Involved in chromosome partitioning
KSAC_RS16370	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KSAC_RS16375	COG1749	Flagellar hook protein flgE
KSAC_RS16385	COG0840	transmembrane signaling receptor activity
KSAC_RS16395	COG0784	Response regulator, receiver
KSAC_RS16395	COG2198	Histidine kinase
KSAC_RS16395	COG0643	Histidine kinase
KSAC_RS16400	COG2198	Histidine kinase
KSAC_RS16400	COG0643	Histidine kinase
KSAC_RS16405	COG0835	chemotaxis
KSAC_RS16410	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KSAC_RS16415	COG2201	protein-glutamate methylesterase activity
KSAC_RS16420	COG0745	RESPONSE REGULATOR receiver
KSAC_RS16425	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
KSAC_RS16470	COG0745	RESPONSE REGULATOR receiver
KSAC_RS16485	COG1706	bacterial-type flagellum-dependent cell motility
KSAC_RS16510	COG1475	DNA binding
KSAC_RS16585	COG0210	DNA helicase
KSAC_RS16590	COG3437	response regulator, receiver
KSAC_RS16610	COG3750	Belongs to the UPF0335 family
KSAC_RS16625	COG4566	intracellular signal transduction
KSAC_RS16630	COG4191	Histidine kinase
KSAC_RS16655	COG0281	malic enzyme
KSAC_RS16675	COG4227	nucleotidyltransferase activity
KSAC_RS16700	COG0629	single-stranded DNA binding
KSAC_RS16790	COG2805	Type II/IV secretion system protein
KSAC_RS16810	COG4974	Belongs to the 'phage' integrase family
KSAC_RS16815	COG3077	Addiction module antitoxin, RelB DinJ family
KSAC_RS16860	COG0587	DNA-directed DNA polymerase activity
KSAC_RS16865	COG0587	DNA-directed DNA polymerase activity