locus-tag	class	description
H845_RS00005	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H845_RS00010	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
H845_RS00030	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H845_RS00040	COG1126	abc transporter atp-binding protein
H845_RS00055	COG2235	arginine
H845_RS00095	COG1566	PFAM secretion protein HlyD family protein
H845_RS00120	COG3842	ATPase activity
H845_RS00135	COG2983	Belongs to the UPF0260 family
H845_RS00150	COG3335	DDE superfamily endonuclease
H845_RS00165	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H845_RS00175	COG0560	Phosphoserine phosphatase
H845_RS00175	COG3830	Belongs to the UPF0237 family
H845_RS00185	COG0028	Belongs to the TPP enzyme family
H845_RS00195	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H845_RS00200	COG0179	Fumarylacetoacetate (FAA) hydrolase
H845_RS00205	COG0667	Aldo Keto reductase
H845_RS00210	COG0542	response to heat
H845_RS00245	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H845_RS00300	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H845_RS00305	COG0492	ferredoxin-NADP+ reductase activity
H845_RS00310	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H845_RS00315	COG2197	response regulator
H845_RS00335	COG2986	histidine ammonia-lyase
H845_RS00340	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H845_RS00355	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H845_RS00375	COG0583	DNA-binding transcription factor activity
H845_RS00380	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H845_RS00395	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H845_RS00395	COG0446	pyridine nucleotide-disulphide oxidoreductase
H845_RS00400	COG4311	Sarcosine oxidase, delta subunit
H845_RS00405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H845_RS00410	COG0583	DNA-binding transcription factor activity
H845_RS00420	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H845_RS00425	COG2218	PFAM glutamate synthase alpha subunit domain protein
H845_RS00430	COG0069	glutamate synthase activity
H845_RS00440	COG0004	ammonium transporteR
H845_RS00445	COG2801	Transposase and inactivated derivatives
H845_RS00470	COG2986	histidine ammonia-lyase
H845_RS00475	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H845_RS00505	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H845_RS00520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H845_RS00535	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H845_RS00540	COG1960	acyl-CoA dehydrogenase activity
H845_RS00565	COG2814	Major facilitator Superfamily
H845_RS00575	COG1139	Iron-sulfur cluster binding protein
H845_RS00580	COG0247	lactate metabolic process
H845_RS00585	COG0277	FAD linked oxidase domain protein
H845_RS00610	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H845_RS00615	COG0659	secondary active sulfate transmembrane transporter activity
H845_RS00630	COG0667	Aldo Keto reductase
H845_RS00635	COG0582	viral genome integration into host DNA
H845_RS00640	COG3093	addiction module antidote protein HigA
H845_RS00665	COG4372	Transposase
H845_RS00690	COG0110	maltose O-acetyltransferase activity
H845_RS00770	COG0596	Alpha beta hydrolase
H845_RS00770	COG0508	dehydrogenase complex catalyzes the overall conversion of
H845_RS00780	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H845_RS00780	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H845_RS00785	COG1999	signal sequence binding
H845_RS00790	COG0747	negative chemotaxis
H845_RS00800	COG4178	(ABC) transporter
H845_RS00805	COG0803	Belongs to the bacterial solute-binding protein 9 family
H845_RS00815	COG1120	ATPase activity
H845_RS00820	COG1280	lysine exporter protein (LysE YggA)
H845_RS00830	COG0114	fumarate hydratase activity
H845_RS00845	COG1028	Short-chain dehydrogenase reductase Sdr
H845_RS00860	COG0415	Belongs to the DNA photolyase family
H845_RS00875	COG2999	glutathione oxidoreductase activity
H845_RS00895	COG0723	plastoquinol--plastocyanin reductase activity
H845_RS00925	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H845_RS00940	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H845_RS00960	COG0745	RESPONSE REGULATOR receiver
H845_RS00965	COG0242	peptide deformylase activity
H845_RS00980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H845_RS00985	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H845_RS00990	COG2202	Pas domain
H845_RS00990	COG2200	EAL domain
H845_RS00990	COG2199	diguanylate cyclase activity
H845_RS01050	COG3299	homolog of phage Mu protein gp47
H845_RS01070	COG3547	Transposase (IS116 IS110 IS902 family)
H845_RS01200	COG0582	viral genome integration into host DNA
H845_RS01220	COG0538	isocitrate dehydrogenase activity
H845_RS01235	COG2862	Uncharacterized protein family, UPF0114
H845_RS01240	COG1959	2 iron, 2 sulfur cluster binding
H845_RS01245	COG0586	Pfam SNARE associated Golgi protein
H845_RS01250	COG0778	Nitroreductase
H845_RS01280	COG1028	Short-chain dehydrogenase reductase Sdr
H845_RS01285	COG0251	oxidation-reduction process
H845_RS01290	COG1289	transmembrane transporter activity
H845_RS01370	COG2610	gluconate transmembrane transporter activity
H845_RS01390	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
H845_RS01440	COG1648	precorrin-2 dehydrogenase activity
H845_RS01440	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H845_RS01450	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H845_RS01455	COG2835	tetraacyldisaccharide 4'-kinase activity
H845_RS01460	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H845_RS01465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H845_RS01475	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H845_RS01475	COG0662	Cupin 2, conserved barrel domain protein
H845_RS01480	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H845_RS01490	COG5001	Diguanylate cyclase
H845_RS01490	COG3300	MHYT domain
H845_RS01515	COG0495	leucyl-tRNA aminoacylation
H845_RS01525	COG1472	Belongs to the glycosyl hydrolase 3 family
H845_RS01555	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H845_RS01560	COG3158	transport of potassium into the cell
H845_RS01565	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H845_RS01575	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H845_RS01585	COG0438	transferase activity, transferring glycosyl groups
H845_RS01595	COG2309	aminopeptidase activity
H845_RS01600	COG2146	nitrite reductase [NAD(P)H] activity
H845_RS01610	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H845_RS01615	COG2945	thiolester hydrolase activity
H845_RS01635	COG0482	sulfurtransferase activity
H845_RS01650	COG0523	cobalamin synthesis protein
H845_RS01670	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H845_RS01680	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
H845_RS01690	COG4974	Belongs to the 'phage' integrase family
H845_RS01710	COG0347	Belongs to the P(II) protein family
H845_RS01715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H845_RS01735	COG1530	ribonuclease E activity
H845_RS01750	COG0860	N-Acetylmuramoyl-L-alanine amidase
H845_RS01760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H845_RS01785	COG0768	penicillin binding
H845_RS01790	COG0772	Belongs to the SEDS family
H845_RS01805	COG0752	glycyl-tRNA synthetase alpha subunit
H845_RS01810	COG3416	Protein conserved in bacteria
H845_RS01820	COG0800	Aldolase
H845_RS01825	COG0129	dihydroxy-acid dehydratase activity
H845_RS01840	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H845_RS01845	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H845_RS01860	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H845_RS01865	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H845_RS01875	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H845_RS01880	COG0509	glycine decarboxylation via glycine cleavage system
H845_RS01885	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H845_RS01885	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H845_RS01895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H845_RS01900	COG1120	ATPase activity
H845_RS01920	COG0346	lactoylglutathione lyase activity
H845_RS01925	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H845_RS01930	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H845_RS01935	COG0552	protein localization to endoplasmic reticulum
H845_RS01945	COG0126	phosphoglycerate kinase activity
H845_RS01965	COG0156	8-amino-7-oxononanoate synthase activity
H845_RS01975	COG0405	Gamma-glutamyltransferase
H845_RS01995	COG1072	(Pantothenic acid kinase))
H845_RS02005	COG1802	Transcriptional regulator
H845_RS02010	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H845_RS02015	COG2894	cell division
H845_RS02020	COG0850	regulation of cytokinetic process
H845_RS02030	COG2081	HI0933 family
H845_RS02035	COG1696	Membrane protein involved in D-alanine export
H845_RS02040	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H845_RS02045	COG0564	pseudouridine synthase activity
H845_RS02060	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H845_RS02060	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H845_RS02070	COG3852	Histidine kinase
H845_RS02085	COG2204	response regulator
H845_RS02090	COG3335	DDE superfamily endonuclease
H845_RS02095	COG3415	Transposase
H845_RS02110	COG1923	regulation of RNA biosynthetic process
H845_RS02115	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H845_RS02120	COG0483	inositol monophosphate 1-phosphatase activity
H845_RS02125	COG3956	TIGRFAM MazG family protein
H845_RS02145	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
H845_RS02150	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H845_RS02160	COG0564	pseudouridine synthase activity
H845_RS02215	COG3161	chorismate lyase activity
H845_RS02225	COG1051	belongs to the nudix hydrolase family
H845_RS02230	COG0326	Molecular chaperone. Has ATPase activity
H845_RS02240	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H845_RS02245	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H845_RS02255	COG0708	Exodeoxyribonuclease III
H845_RS02265	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H845_RS02270	COG0018	arginyl-trna synthetase
H845_RS02280	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H845_RS02285	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H845_RS02290	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H845_RS02295	COG0805	protein transport
H845_RS02300	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H845_RS02325	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H845_RS02340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H845_RS02350	COG0215	cysteine-tRNA ligase activity
H845_RS02355	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H845_RS02360	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H845_RS02390	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H845_RS02395	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H845_RS02405	COG2885	chlorophyll binding
H845_RS02405	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H845_RS02410	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H845_RS02410	COG2885	chlorophyll binding
H845_RS02415	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H845_RS02415	COG2885	chlorophyll binding
H845_RS02420	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H845_RS02440	COG0825	malonyl-CoA metabolic process
H845_RS02445	COG1546	Belongs to the CinA family
H845_RS02445	COG1058	Belongs to the CinA family
H845_RS02470	COG1862	Preprotein translocase
H845_RS02475	COG2814	Major facilitator Superfamily
H845_RS02515	COG1758	RNA polymerase activity
H845_RS02525	COG0736	holo-[acyl-carrier-protein] synthase activity
H845_RS02530	COG0681	Belongs to the peptidase S26 family
H845_RS02535	COG0571	ribonuclease III activity
H845_RS02540	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H845_RS02545	COG0528	UMP kinase activity
H845_RS02550	COG0233	cytoplasmic translational termination
H845_RS02555	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H845_RS02565	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H845_RS02570	COG0750	zinc metalloprotease
H845_RS02575	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H845_RS02585	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H845_RS02590	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H845_RS02595	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H845_RS02600	COG3494	Protein of unknown function (DUF1009)
H845_RS02605	COG0346	lactoylglutathione lyase activity
H845_RS02615	COG0594	ribonuclease P activity
H845_RS02620	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H845_RS02625	COG0706	membrane insertase activity
H845_RS02630	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H845_RS02635	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H845_RS02640	COG2171	N-acyltransferase activity
H845_RS02645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H845_RS02655	COG0101	tRNA pseudouridine synthase activity
H845_RS02660	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H845_RS02665	COG0242	peptide deformylase activity
H845_RS02680	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H845_RS02685	COG1137	ATPase activity
H845_RS02735	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H845_RS02740	COG0556	nucleotide-excision repair
H845_RS02755	COG0189	ligase activity
H845_RS02765	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H845_RS02770	COG0109	protoheme IX farnesyltransferase activity
H845_RS02780	COG0312	modulator of DNA gyrase
H845_RS02785	COG0612	Peptidase, M16
H845_RS02800	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H845_RS02810	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H845_RS02815	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H845_RS02820	COG0728	peptidoglycan biosynthetic process
H845_RS02825	COG0386	Belongs to the glutathione peroxidase family
H845_RS02830	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H845_RS02835	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H845_RS02840	COG0181	hydroxymethylbilane synthase activity
H845_RS02850	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H845_RS02870	COG1858	cytochrome C peroxidase
H845_RS02885	COG0408	coproporphyrinogen oxidase activity
H845_RS02890	COG2857	Cytochrome c1
H845_RS02890	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H845_RS02895	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H845_RS02900	COG0412	Dienelactone hydrolase
H845_RS02910	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H845_RS02915	COG0459	protein refolding
H845_RS02920	COG1278	Cold shock
H845_RS02925	COG1199	ATP-dependent helicase activity
H845_RS02940	COG2095	MarC family integral membrane protein
H845_RS02970	COG0670	Belongs to the BI1 family
H845_RS02990	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H845_RS03010	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H845_RS03025	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H845_RS03045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H845_RS03050	COG0628	permease
H845_RS03055	COG2814	Major facilitator Superfamily
H845_RS03060	COG0488	(ABC) transporter
H845_RS03065	COG0105	UTP biosynthetic process
H845_RS03070	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H845_RS03075	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H845_RS03085	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H845_RS03100	COG2080	2 iron, 2 sulfur cluster binding
H845_RS03105	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H845_RS03115	COG0583	DNA-binding transcription factor activity
H845_RS03120	COG2072	flavoprotein involved in K transport
H845_RS03145	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H845_RS03160	COG2351	hydroxyisourate hydrolase activity
H845_RS03165	COG0473	3-isopropylmalate dehydrogenase activity
H845_RS03170	COG0006	proline dipeptidase activity
H845_RS03180	COG2264	protein methyltransferase activity
H845_RS03185	COG0210	DNA helicase
H845_RS03190	COG2003	Belongs to the UPF0758 family
H845_RS03200	COG2003	Belongs to the UPF0758 family
H845_RS03205	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H845_RS03225	COG0071	Belongs to the small heat shock protein (HSP20) family
H845_RS03230	COG0254	rRNA binding
H845_RS03235	COG1970	mechanosensitive ion channel activity
H845_RS03250	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H845_RS03255	COG0673	inositol 2-dehydrogenase activity
H845_RS03260	COG0488	(ABC) transporter
H845_RS03265	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H845_RS03270	COG0784	Response regulator, receiver
H845_RS03295	COG4988	ABC transporter
H845_RS03300	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H845_RS03315	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H845_RS03320	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H845_RS03325	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H845_RS03340	COG0837	glucose binding
H845_RS03405	COG1695	Transcriptional regulator
H845_RS03415	COG0477	Major facilitator Superfamily
H845_RS03425	COG1595	DNA-templated transcription, initiation
H845_RS03435	COG4774	siderophore transport
H845_RS03475	COG0848	biopolymer transport protein
H845_RS03495	COG4771	TonB-dependent receptor
H845_RS03500	COG4558	Periplasmic binding protein
H845_RS03505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H845_RS03510	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H845_RS03535	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H845_RS03545	COG0745	RESPONSE REGULATOR receiver
H845_RS03545	COG2205	protein histidine kinase activity
H845_RS03545	COG4191	Histidine kinase
H845_RS03565	COG2207	Transcriptional regulator
H845_RS03575	COG3609	addiction module antidote protein, CC2985 family
H845_RS03670	COG3293	Transposase
H845_RS03710	COG2267	carboxylic ester hydrolase activity
H845_RS03715	COG1113	amino acid transport
H845_RS03750	COG2801	Transposase and inactivated derivatives
H845_RS03765	COG1408	metallophosphoesterase
H845_RS03770	COG2070	2-Nitropropane dioxygenase
H845_RS03775	COG2211	Major facilitator Superfamily
H845_RS03780	COG0384	phenazine biosynthesis protein PhzF
H845_RS03795	COG3226	Transcriptional regulator
H845_RS03805	COG0697	spore germination
H845_RS03815	COG0698	ribose 5-phosphate isomerase
H845_RS03820	COG2376	Dihydroxyacetone kinase
H845_RS03825	COG2814	Major facilitator Superfamily
H845_RS03830	COG1028	Short-chain dehydrogenase reductase Sdr
H845_RS03840	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H845_RS03850	COG0583	DNA-binding transcription factor activity
H845_RS03855	COG1028	Short-chain dehydrogenase reductase Sdr
H845_RS03865	COG3300	MHYT domain
H845_RS03865	COG5001	Diguanylate cyclase
H845_RS03870	COG2200	EAL domain
H845_RS03870	COG2199	diguanylate cyclase activity
H845_RS03870	COG2202	Pas domain
H845_RS03885	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H845_RS03890	COG0022	dehydrogenase e1 component
H845_RS03900	COG1070	Carbohydrate kinase
H845_RS03910	COG2814	Major facilitator Superfamily
H845_RS03930	COG1091	dTDP-4-dehydrorhamnose reductase activity
H845_RS03940	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H845_RS03955	COG0438	transferase activity, transferring glycosyl groups
H845_RS03970	COG1215	transferase activity, transferring glycosyl groups
H845_RS03975	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H845_RS03985	COG0662	Cupin 2, conserved barrel domain protein
H845_RS03985	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H845_RS04020	COG1596	polysaccharide export
H845_RS04025	COG2755	lipolytic protein G-D-S-L family
H845_RS04025	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H845_RS04080	COG0038	chloride channel
H845_RS04095	COG5564	TIM-barrel signal transduction protein
H845_RS04100	COG5441	Belongs to the UPF0261 family
H845_RS04115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H845_RS04125	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H845_RS04160	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H845_RS04170	COG0525	valine-tRNA ligase activity
H845_RS04175	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H845_RS04180	COG1116	anion transmembrane transporter activity
H845_RS04190	COG0756	dUTP diphosphatase activity
H845_RS04200	COG2226	methyltransferase
H845_RS04205	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H845_RS04210	COG0268	Binds directly to 16S ribosomal RNA
H845_RS04215	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H845_RS04225	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H845_RS04235	COG0546	phosphoglycolate phosphatase activity
H845_RS04240	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H845_RS04245	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H845_RS04260	COG2022	thiamine diphosphate biosynthetic process
H845_RS04280	COG0019	diaminopimelate decarboxylase activity
H845_RS04285	COG0295	cytidine deaminase activity
H845_RS04290	COG0165	Argininosuccinate lyase
H845_RS04300	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H845_RS04305	COG0237	dephospho-CoA kinase activity
H845_RS04310	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H845_RS04325	COG1136	(ABC) transporter
H845_RS04340	COG0659	secondary active sulfate transmembrane transporter activity
H845_RS04350	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H845_RS04355	COG0602	queuosine metabolic process
H845_RS04360	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H845_RS04370	COG0045	succinate-CoA ligase (ADP-forming) activity
H845_RS04390	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H845_RS04410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H845_RS04415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H845_RS04420	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H845_RS04430	COG0483	inositol monophosphate 1-phosphatase activity
H845_RS04475	COG0156	8-amino-7-oxononanoate synthase activity
H845_RS04485	COG0318	PFAM AMP-dependent synthetase and ligase
H845_RS04575	COG4962	Type ii secretion system protein e
H845_RS04580	COG3838	Conjugal transfer protein Trbc
H845_RS04590	COG3451	type IV secretory pathway VirB4
H845_RS04605	COG3701	Conjugal transfer protein
H845_RS04640	COG0587	DNA-directed DNA polymerase activity
H845_RS04645	COG0625	glutathione transferase activity
H845_RS04730	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H845_RS04735	COG0657	acetylesterase activity
H845_RS04745	COG2801	Transposase and inactivated derivatives
H845_RS04750	COG0587	DNA-directed DNA polymerase activity
H845_RS04775	COG4716	Myosin-crossreactive antigen
H845_RS04780	COG3293	Transposase
H845_RS04795	COG2963	transposase activity
H845_RS04800	COG2801	Transposase and inactivated derivatives
H845_RS04830	COG2189	Belongs to the N(4) N(6)-methyltransferase family
H845_RS04835	COG2801	Transposase and inactivated derivatives
H845_RS04840	COG2963	transposase activity
H845_RS04855	COG0437	4 iron, 4 sulfur cluster binding
H845_RS04890	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H845_RS04895	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H845_RS04900	COG1845	cytochrome c oxidase, subunit III
H845_RS04915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H845_RS04920	COG1538	Outer membrane efflux protein
H845_RS04990	COG1942	4-Oxalocrotonate Tautomerase
H845_RS04995	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H845_RS05030	COG4650	regulator
H845_RS05045	COG1953	Uracil, thiamine, allantoin
H845_RS05050	COG1846	Transcriptional regulator
H845_RS05055	COG2271	Major facilitator Superfamily
H845_RS05065	COG3473	Maleate cis-trans isomerase
H845_RS05070	COG1335	isochorismatase
H845_RS05075	COG2309	aminopeptidase activity
H845_RS05080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H845_RS05100	COG3335	DDE superfamily endonuclease
H845_RS05165	COG0583	DNA-binding transcription factor activity
H845_RS05185	COG0583	DNA-binding transcription factor activity
H845_RS05195	COG0431	NADPH-dependent FMN reductase
H845_RS05205	COG0753	catalase activity
H845_RS05225	COG2807	transmembrane transport
H845_RS05235	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H845_RS05240	COG2814	Major facilitator Superfamily
H845_RS05245	COG0513	Belongs to the DEAD box helicase family
H845_RS05265	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H845_RS05270	COG1858	cytochrome C peroxidase
H845_RS05280	COG0823	Involved in the tonB-independent uptake of proteins
H845_RS05285	COG0745	RESPONSE REGULATOR receiver
H845_RS05290	COG0745	RESPONSE REGULATOR receiver
H845_RS05300	COG1695	Transcriptional regulator
H845_RS05315	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H845_RS05330	COG1113	amino acid transport
H845_RS05335	COG0517	IMP dehydrogenase activity
H845_RS05335	COG0516	GMP reductase activity
H845_RS05340	COG1007	ATP synthesis coupled electron transport
H845_RS05355	COG0713	ATP synthesis coupled electron transport
H845_RS05360	COG0839	Belongs to the complex I subunit 6 family
H845_RS05370	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H845_RS05375	COG1034	ATP synthesis coupled electron transport
H845_RS05390	COG0649	NAD binding
H845_RS05390	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H845_RS05395	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H845_RS05400	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H845_RS05430	COG0477	Major facilitator Superfamily
H845_RS05440	COG3511	phospholipase C
H845_RS05460	COG0531	amino acid
H845_RS05465	COG1228	amidohydrolase
H845_RS05480	COG1063	alcohol dehydrogenase
H845_RS05485	COG1028	Short-chain dehydrogenase reductase Sdr
H845_RS05500	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H845_RS05505	COG1574	metal-dependent hydrolase with the TIM-barrel fold
H845_RS05510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H845_RS05530	COG2368	4-hydroxyphenylacetate
H845_RS05550	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H845_RS05555	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H845_RS05560	COG2986	histidine ammonia-lyase
H845_RS05580	COG0277	FAD linked oxidase domain protein
H845_RS05585	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H845_RS05600	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
H845_RS05605	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
H845_RS05620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H845_RS05625	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H845_RS05630	COG1942	4-Oxalocrotonate Tautomerase
H845_RS05655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H845_RS05690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H845_RS05695	COG2259	Doxx family
H845_RS05710	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H845_RS05780	COG1028	Short-chain dehydrogenase reductase Sdr
H845_RS05790	COG1054	Belongs to the UPF0176 family
H845_RS05795	COG1393	Belongs to the ArsC family
H845_RS05800	COG1113	amino acid transport
H845_RS05805	COG1597	lipid kinase activity
H845_RS05810	COG3191	aminopeptidase activity
H845_RS05815	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H845_RS05830	COG0154	amidase activity
H845_RS05850	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H845_RS05870	COG0420	3'-5' exonuclease activity
H845_RS05875	COG1012	belongs to the aldehyde dehydrogenase family
H845_RS05880	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H845_RS05885	COG0583	DNA-binding transcription factor activity
H845_RS05900	COG1278	Cold shock
H845_RS05905	COG3128	pkhd-type hydroxylase
H845_RS05910	COG4774	siderophore transport
H845_RS05930	COG0583	DNA-binding transcription factor activity
H845_RS05935	COG0281	malic enzyme
H845_RS05940	COG1289	transmembrane transporter activity
H845_RS05960	COG0583	DNA-binding transcription factor activity
H845_RS05965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H845_RS05970	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H845_RS05975	COG1522	sequence-specific DNA binding
H845_RS05990	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H845_RS05995	COG1494	fructose-1,6-bisphosphatase
H845_RS06000	COG0191	fructose-bisphosphate aldolase activity
H845_RS06010	COG1028	Short-chain dehydrogenase reductase Sdr
H845_RS06015	COG1252	NADH dehydrogenase
H845_RS06025	COG2011	ABC-type metal ion transport system permease component
H845_RS06035	COG1464	Belongs to the NlpA lipoprotein family
H845_RS06050	COG1012	belongs to the aldehyde dehydrogenase family
H845_RS06055	COG1252	NADH dehydrogenase
H845_RS06060	COG1309	transcriptional regulator
H845_RS06070	COG0842	Transport permease protein
H845_RS06075	COG0842	Transport permease protein
H845_RS06075	COG1129	ABC transporter
H845_RS06080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H845_RS06110	COG0306	phosphate transporter
H845_RS06120	COG0573	inorganic phosphate transmembrane transporter activity
H845_RS06130	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H845_RS06140	COG0277	FAD linked oxidase domain protein
H845_RS06150	COG1116	anion transmembrane transporter activity
H845_RS06175	COG0753	catalase activity
H845_RS06195	COG1584	GPR1 FUN34 yaaH family protein
H845_RS06200	COG1231	oxidoreductase activity
H845_RS06225	COG1289	transmembrane transporter activity
H845_RS06260	COG0730	response to heat
H845_RS06285	COG0443	Heat shock 70 kDa protein
H845_RS06295	COG3104	oligopeptide transport
H845_RS06300	COG2134	cdp-diacylglycerol pyrophosphatase
H845_RS06305	COG0300	oxidoreductase activity
H845_RS06345	COG0058	SHG alpha-glucan phosphorylase activity
H845_RS06350	COG0297	glycogen (starch) synthase activity
H845_RS06355	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H845_RS06370	COG1640	4-alpha-glucanotransferase
H845_RS06415	COG0668	transmembrane transport
H845_RS06420	COG1914	H( )-stimulated, divalent metal cation uptake system
H845_RS06430	COG0667	Aldo Keto reductase
H845_RS06435	COG0583	DNA-binding transcription factor activity
H845_RS06445	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H845_RS06455	COG1253	flavin adenine dinucleotide binding
H845_RS06465	COG0583	DNA-binding transcription factor activity
H845_RS06475	COG3634	alkyl hydroperoxide reductase activity
H845_RS06480	COG1012	belongs to the aldehyde dehydrogenase family
H845_RS06495	COG3384	dioxygenase
H845_RS06535	COG0444	Belongs to the ABC transporter superfamily
H845_RS06545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H845_RS06555	COG1028	Short-chain dehydrogenase reductase Sdr
H845_RS06565	COG1956	GAF domain-containing protein
H845_RS06575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H845_RS06585	COG1741	Belongs to the pirin family
H845_RS06590	COG0583	DNA-binding transcription factor activity
H845_RS06595	COG0655	NAD(P)H dehydrogenase (quinone) activity
H845_RS06600	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H845_RS06630	COG2837	iron assimilation
H845_RS06645	COG2755	lipolytic protein G-D-S-L family
H845_RS06645	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H845_RS06650	COG0596	Alpha beta hydrolase
H845_RS06660	COG0500	methyltransferase
H845_RS06675	COG1063	alcohol dehydrogenase
H845_RS06690	COG0697	spore germination
H845_RS06695	COG0625	glutathione transferase activity
H845_RS06755	COG2271	Major facilitator Superfamily
H845_RS06760	COG0583	DNA-binding transcription factor activity
H845_RS06790	COG0363	glucosamine-6-phosphate deaminase activity
H845_RS06795	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H845_RS06800	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H845_RS06805	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H845_RS06820	COG4716	Myosin-crossreactive antigen
H845_RS06840	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H845_RS06845	COG3588	fructose-bisphosphate aldolase
H845_RS06850	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H845_RS06855	COG1396	sequence-specific DNA binding
H845_RS06855	COG3800	Transcriptional regulator
H845_RS06885	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H845_RS06890	COG0436	Aminotransferase
H845_RS06895	COG2271	Major facilitator Superfamily
H845_RS06900	COG0697	spore germination
H845_RS06905	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H845_RS06910	COG1984	allophanate hydrolase subunit 2
H845_RS06915	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H845_RS06920	COG4221	oxidoreductase activity
H845_RS06925	COG0511	ligase activity, forming carbon-carbon bonds
H845_RS06940	COG1027	Aspartate ammonia-lyase
H845_RS06960	COG1032	radical SAM domain protein
H845_RS07010	COG1744	ABC transporter substrate-binding protein PnrA-like
H845_RS07015	COG3586	endonuclease activity
H845_RS07020	COG0402	S-adenosylhomocysteine deaminase activity
H845_RS07035	COG4251	negative regulation of phosphorylation
H845_RS07040	COG2200	EAL domain
H845_RS07040	COG2199	diguanylate cyclase activity
H845_RS07040	COG2202	Pas domain
H845_RS07050	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H845_RS07070	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H845_RS07075	COG2200	EAL domain
H845_RS07075	COG2202	Pas domain
H845_RS07075	COG2199	diguanylate cyclase activity
H845_RS07085	COG1959	2 iron, 2 sulfur cluster binding
H845_RS07090	COG1959	2 iron, 2 sulfur cluster binding
H845_RS07100	COG0303	'Molybdopterin
H845_RS07105	COG1763	Mo-molybdopterin cofactor biosynthetic process
H845_RS07110	COG0746	molybdenum cofactor guanylyltransferase activity
H845_RS07115	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H845_RS07125	COG4993	Dehydrogenase
H845_RS07130	COG0519	Catalyzes the synthesis of GMP from XMP
H845_RS07165	COG3042	response to heat
H845_RS07205	COG0405	Gamma-glutamyltransferase
H845_RS07225	COG1902	pentaerythritol trinitrate reductase activity
H845_RS07280	COG3415	Transposase
H845_RS07285	COG3335	DDE superfamily endonuclease
H845_RS07295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H845_RS07480	COG1285	pathogenesis
H845_RS07540	COG1271	oxidase subunit
H845_RS07545	COG1294	oxidase, subunit
H845_RS07555	COG0071	Belongs to the small heat shock protein (HSP20) family
H845_RS07605	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H845_RS07620	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H845_RS07625	COG2218	PFAM glutamate synthase alpha subunit domain protein
H845_RS07630	COG0069	glutamate synthase activity
H845_RS07640	COG0446	pyridine nucleotide-disulphide oxidoreductase
H845_RS07640	COG1902	pentaerythritol trinitrate reductase activity
H845_RS07700	COG0493	'glutamate synthase
H845_RS07710	COG1953	Uracil, thiamine, allantoin
H845_RS07715	COG3800	Transcriptional regulator
H845_RS07715	COG1396	sequence-specific DNA binding
H845_RS07725	COG3335	DDE superfamily endonuclease
H845_RS07730	COG2079	MmgE PrpD family protein
H845_RS07735	COG0372	Belongs to the citrate synthase family
H845_RS07740	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H845_RS07745	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H845_RS07755	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H845_RS07755	COG0506	proline dehydrogenase activity
H845_RS07755	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H845_RS07785	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H845_RS07800	COG4221	oxidoreductase activity
H845_RS07820	COG1113	amino acid transport
H845_RS07830	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H845_RS07835	COG0583	DNA-binding transcription factor activity
H845_RS07845	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H845_RS07850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H845_RS07860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H845_RS07870	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H845_RS07875	COG0154	amidase activity
H845_RS07880	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H845_RS07885	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H845_RS07900	COG2824	Alkylphosphonate utilization operon protein PhnA
H845_RS07910	COG1671	Belongs to the UPF0178 family
H845_RS07955	COG0628	permease
H845_RS07965	COG0732	type I restriction modification DNA specificity domain
H845_RS07985	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H845_RS07990	COG0483	inositol monophosphate 1-phosphatase activity
H845_RS07995	COG3474	cytochrome
H845_RS08000	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H845_RS08010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H845_RS08015	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H845_RS08020	COG1278	Cold shock
H845_RS08025	COG1309	transcriptional regulator
H845_RS08030	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H845_RS08035	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H845_RS08040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H845_RS08055	COG0076	glutamate decarboxylase activity
H845_RS08085	COG0321	lipoyl(octanoyl) transferase activity
H845_RS08115	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H845_RS08120	COG2226	methyltransferase
H845_RS08125	COG1040	competence protein
H845_RS08145	COG2706	6-phosphogluconolactonase activity
H845_RS08150	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H845_RS08160	COG2070	2-Nitropropane dioxygenase
H845_RS08165	COG1426	Protein conserved in bacteria
H845_RS08170	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H845_RS08175	COG0124	histidyl-tRNA synthetase
H845_RS08180	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H845_RS08190	COG2890	protein-(glutamine-N5) methyltransferase activity
H845_RS08205	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H845_RS08210	COG0156	8-amino-7-oxononanoate synthase activity
H845_RS08220	COG4106	trans-aconitate 2-methyltransferase activity
H845_RS08220	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H845_RS08225	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H845_RS08230	COG0303	'Molybdopterin
H845_RS08235	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H845_RS08245	COG0148	phosphopyruvate hydratase activity
H845_RS08265	COG2010	Cytochrome c
H845_RS08265	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H845_RS08270	COG4993	Dehydrogenase
H845_RS08280	COG0438	transferase activity, transferring glycosyl groups
H845_RS08285	COG0305	Participates in initiation and elongation during chromosome replication
H845_RS08315	COG0513	Belongs to the DEAD box helicase family
H845_RS08325	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H845_RS08335	COG0113	porphobilinogen synthase activity
H845_RS08340	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H845_RS08345	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H845_RS08350	COG1381	Involved in DNA repair and RecF pathway recombination
H845_RS08355	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H845_RS08360	COG0052	Belongs to the universal ribosomal protein uS2 family
H845_RS08365	COG1764	response to oxidative stress
H845_RS08370	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H845_RS08375	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H845_RS08380	COG0259	pyridoxamine-phosphate oxidase activity
H845_RS08390	COG0175	sulfate reduction
H845_RS08410	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H845_RS08420	COG1519	Transferase
H845_RS08425	COG1663	tetraacyldisaccharide 4'-kinase activity
H845_RS08445	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H845_RS08470	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H845_RS08490	COG1160	GTP binding
H845_RS08515	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H845_RS08525	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H845_RS08535	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H845_RS08535	COG0072	phenylalanine-tRNA ligase activity
H845_RS08540	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H845_RS08545	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H845_RS08550	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H845_RS08555	COG1028	Short-chain dehydrogenase reductase Sdr
H845_RS08560	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H845_RS08585	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H845_RS08590	COG1940	carbohydrate kinase activity
H845_RS08595	COG0425	Belongs to the sulfur carrier protein TusA family
H845_RS08600	COG1722	exodeoxyribonuclease VII activity
H845_RS08610	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H845_RS08615	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
H845_RS08620	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H845_RS08625	COG0137	argininosuccinate synthase activity
H845_RS08630	COG0545	Peptidyl-prolyl cis-trans isomerase
H845_RS08640	COG0180	Tryptophanyl-tRNA synthetase
H845_RS08645	COG0432	Pfam Uncharacterised protein family UPF0047
H845_RS08650	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H845_RS08655	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H845_RS08660	COG3781	membrane
H845_RS08675	COG0729	surface antigen
H845_RS08680	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H845_RS08685	COG1702	phosphate starvation-inducible protein PhoH
H845_RS08690	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H845_RS08720	COG1605	Chorismate mutase
H845_RS08720	COG0287	Prephenate dehydrogenase
H845_RS08740	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H845_RS08745	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H845_RS08750	COG0142	geranyltranstransferase activity
H845_RS08765	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H845_RS08765	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H845_RS08770	COG0314	molybdopterin synthase activity
H845_RS08775	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H845_RS08790	COG0322	excinuclease ABC activity
H845_RS08800	COG0745	RESPONSE REGULATOR receiver
H845_RS08825	COG1234	tRNA 3'-trailer cleavage
H845_RS08830	COG0084	hydrolase, TatD family'
H845_RS08845	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H845_RS08850	COG1686	Belongs to the peptidase S11 family
H845_RS08855	COG2951	lytic endotransglycosylase activity
H845_RS08860	COG0586	Pfam SNARE associated Golgi protein
H845_RS08870	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H845_RS08875	COG1968	undecaprenyl-diphosphatase activity
H845_RS08990	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H845_RS09015	COG1272	protein, Hemolysin III
H845_RS09035	COG2814	Major facilitator Superfamily
H845_RS09065	COG0626	cystathionine gamma-synthase activity
H845_RS09075	COG0628	permease
H845_RS09095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H845_RS09100	COG0792	nuclease activity
H845_RS09110	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H845_RS09115	COG0271	Belongs to the BolA IbaG family
H845_RS09120	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H845_RS09125	COG0047	phosphoribosylformylglycinamidine synthase activity
H845_RS09135	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H845_RS09140	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H845_RS09150	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H845_RS09155	COG0861	Integral membrane protein TerC family
H845_RS09165	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H845_RS09170	COG1546	Belongs to the CinA family
H845_RS09170	COG1058	Belongs to the CinA family
H845_RS09185	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H845_RS09190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H845_RS09195	COG0508	dehydrogenase complex catalyzes the overall conversion of
H845_RS09200	COG0022	dehydrogenase e1 component
H845_RS09200	COG0508	dehydrogenase complex catalyzes the overall conversion of
H845_RS09205	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H845_RS09210	COG0315	cyclic pyranopterin monophosphate synthase activity
H845_RS09215	COG0134	indole-3-glycerol-phosphate synthase activity
H845_RS09220	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H845_RS09230	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H845_RS09240	COG0149	triose-phosphate isomerase activity
H845_RS09250	COG0504	CTP synthase activity
H845_RS09255	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H845_RS09280	COG2032	superoxide dismutase activity
H845_RS09365	COG2375	cellular response to nickel ion
H845_RS09380	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H845_RS09380	COG0519	Catalyzes the synthesis of GMP from XMP
H845_RS09420	COG1522	sequence-specific DNA binding
H845_RS09425	COG0492	ferredoxin-NADP+ reductase activity
H845_RS09430	COG0583	DNA-binding transcription factor activity
H845_RS09435	COG0776	regulation of translation
H845_RS09440	COG0616	signal peptide processing
H845_RS09465	COG1573	uracil-dna glycosylase
H845_RS09470	COG1289	transmembrane transporter activity
H845_RS09475	COG0402	S-adenosylhomocysteine deaminase activity
H845_RS09485	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H845_RS09490	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H845_RS09510	COG3750	Belongs to the UPF0335 family
H845_RS09515	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H845_RS09525	COG0657	acetylesterase activity
H845_RS09530	COG2001	Belongs to the MraZ family
H845_RS09535	COG0275	rRNA processing
H845_RS09550	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H845_RS09555	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H845_RS09560	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H845_RS09565	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H845_RS09575	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H845_RS09580	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H845_RS09585	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H845_RS09590	COG1181	Belongs to the D-alanine--D-alanine ligase family
H845_RS09595	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H845_RS09600	COG0849	cell division
H845_RS09610	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H845_RS09615	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H845_RS09625	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H845_RS09630	COG1744	ABC transporter substrate-binding protein PnrA-like
H845_RS09635	COG3845	ABC transporter
H845_RS09640	COG4603	Belongs to the binding-protein-dependent transport system permease family
H845_RS09645	COG1079	Belongs to the binding-protein-dependent transport system permease family
H845_RS09685	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
H845_RS09715	COG1028	Short-chain dehydrogenase reductase Sdr
H845_RS09720	COG1012	belongs to the aldehyde dehydrogenase family
H845_RS09750	COG2244	polysaccharide biosynthetic process
H845_RS09785	COG0513	Belongs to the DEAD box helicase family
H845_RS09790	COG0778	Nitroreductase
H845_RS09795	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H845_RS09795	COG2813	Specifically methylates the guanine in position
H845_RS09800	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H845_RS09810	COG1136	(ABC) transporter
H845_RS09820	COG0442	prolyl-tRNA aminoacylation
H845_RS09835	COG1007	ATP synthesis coupled electron transport
H845_RS09845	COG0713	ATP synthesis coupled electron transport
H845_RS09855	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H845_RS09860	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H845_RS09865	COG1034	ATP synthesis coupled electron transport
H845_RS09875	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
H845_RS09880	COG0649	NAD binding
H845_RS09885	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H845_RS09890	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H845_RS09895	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H845_RS09910	COG0776	regulation of translation
H845_RS09920	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H845_RS09925	COG0740	serine-type endopeptidase activity
H845_RS09930	COG0544	peptidyl-prolyl cis-trans isomerase activity
H845_RS09950	COG0513	Belongs to the DEAD box helicase family
H845_RS09960	COG0316	Belongs to the HesB IscA family
H845_RS09965	COG2151	metal-sulfur cluster biosynthetic enzyme
H845_RS09975	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H845_RS09980	COG0719	Fe-S assembly protein
H845_RS09985	COG0396	ATPase activity
H845_RS09990	COG0719	Fe-S assembly protein
H845_RS10000	COG2733	membrane
H845_RS10005	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H845_RS10015	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H845_RS10020	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H845_RS10030	COG5265	(ABC) transporter
H845_RS10045	COG0628	permease
H845_RS10060	COG0776	regulation of translation
H845_RS10065	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H845_RS10070	COG0416	fatty acid biosynthetic process
H845_RS10090	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H845_RS10095	COG0242	peptide deformylase activity
H845_RS10110	COG0745	RESPONSE REGULATOR receiver
H845_RS10115	COG0473	3-isopropylmalate dehydrogenase activity
H845_RS10120	COG0066	3-isopropylmalate dehydratase activity
H845_RS10125	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H845_RS10130	COG0335	large ribosomal subunit rRNA binding
H845_RS10135	COG0336	Belongs to the RNA methyltransferase TrmD family
H845_RS10140	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H845_RS10145	COG0228	four-way junction DNA binding
H845_RS10160	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H845_RS10165	COG0581	inorganic phosphate transmembrane transporter activity
H845_RS10170	COG0573	inorganic phosphate transmembrane transporter activity
H845_RS10180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H845_RS10185	COG1116	anion transmembrane transporter activity
H845_RS10190	COG0328	RNA-DNA hybrid ribonuclease activity
H845_RS10195	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H845_RS10200	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H845_RS10210	COG1297	OPT oligopeptide transporter protein
H845_RS10225	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
H845_RS10245	COG3265	gluconokinase activity
H845_RS10260	COG0436	Aminotransferase
H845_RS10270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H845_RS10285	COG1032	radical SAM domain protein
H845_RS10300	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H845_RS10305	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H845_RS10355	COG2884	Cell division ATP-binding protein ftsE
H845_RS10375	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
H845_RS10380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H845_RS10390	COG0688	phosphatidylethanolamine metabolic process
H845_RS10400	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H845_RS10430	COG0656	L-ascorbic acid biosynthetic process
H845_RS10440	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H845_RS10450	COG0009	L-threonylcarbamoyladenylate synthase
H845_RS10460	COG0277	FAD linked oxidase domain protein
H845_RS10475	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H845_RS10485	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H845_RS10490	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H845_RS10495	COG0359	binds to the 23S rRNA
H845_RS10500	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H845_RS10505	COG0360	Binds together with S18 to 16S ribosomal RNA
H845_RS10515	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H845_RS10520	COG0358	DNA primase activity
H845_RS10530	COG0505	Belongs to the CarA family
H845_RS10535	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H845_RS10540	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H845_RS10545	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H845_RS10550	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H845_RS10555	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H845_RS10560	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H845_RS10570	COG0793	Belongs to the peptidase S41A family
H845_RS10575	COG1051	belongs to the nudix hydrolase family
H845_RS10580	COG0494	nUDIX hydrolase
H845_RS10585	COG2814	Major facilitator Superfamily
H845_RS10590	COG1566	PFAM secretion protein HlyD family protein
H845_RS10595	COG1132	(ABC) transporter
H845_RS10610	COG0714	Associated with various cellular activities
H845_RS10640	COG2189	Belongs to the N(4) N(6)-methyltransferase family
H845_RS10645	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H845_RS10655	COG2814	Major facilitator Superfamily
H845_RS10670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H845_RS10690	COG1116	anion transmembrane transporter activity
H845_RS10705	COG0203	ribosomal protein L17
H845_RS10710	COG0202	RNA polymerase activity
H845_RS10715	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H845_RS10720	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H845_RS10725	COG0563	adenylate kinase activity
H845_RS10730	COG0201	protein transport
H845_RS10735	COG0200	Binds to the 23S rRNA
H845_RS10740	COG1841	ribosomal large subunit assembly
H845_RS10745	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H845_RS10750	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H845_RS10755	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H845_RS10760	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H845_RS10765	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H845_RS10770	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H845_RS10775	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H845_RS10780	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H845_RS10785	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H845_RS10790	COG0255	Belongs to the universal ribosomal protein uL29 family
H845_RS10795	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H845_RS10800	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H845_RS10805	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H845_RS10810	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H845_RS10815	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H845_RS10820	COG0089	rRNA binding
H845_RS10825	COG0088	Forms part of the polypeptide exit tunnel
H845_RS10830	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H845_RS10835	COG0051	transcription antitermination factor activity, RNA binding
H845_RS10840	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H845_RS10845	COG0049	tRNA binding
H845_RS10855	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H845_RS10860	COG0085	RNA polymerase activity
H845_RS10865	COG0222	ribosome binding
H845_RS10870	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H845_RS10875	COG0081	regulation of translation
H845_RS10880	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H845_RS10900	COG5002	protein histidine kinase activity
H845_RS10915	COG1301	dicarboxylic acid transport
H845_RS10920	COG0477	Major facilitator Superfamily
H845_RS10935	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H845_RS10955	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H845_RS10985	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H845_RS10990	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H845_RS10995	COG1138	Cytochrome C-type biogenesis protein
H845_RS11000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H845_RS11005	COG3088	subunit of a heme lyase
H845_RS11015	COG5508	conserved small protein
H845_RS11030	COG0612	Peptidase, M16
H845_RS11035	COG0539	negative regulation of cytoplasmic translation
H845_RS11040	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H845_RS11045	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H845_RS11060	COG1028	Short-chain dehydrogenase reductase Sdr
H845_RS11065	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H845_RS11070	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H845_RS11085	COG0024	Methionine aminopeptidase
H845_RS11090	COG1686	Belongs to the peptidase S11 family
H845_RS11095	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H845_RS11105	COG1742	UPF0060 membrane protein
H845_RS11115	COG2326	polyphosphate kinase activity
H845_RS11120	COG4221	oxidoreductase activity
H845_RS11125	COG1678	Uncharacterized ACR, COG1678
H845_RS11135	COG0167	dihydroorotate dehydrogenase activity
H845_RS11160	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H845_RS11165	COG1492	cobalamin metabolic process
H845_RS11180	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H845_RS11185	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
H845_RS11205	COG1113	amino acid transport
H845_RS11215	COG0252	asparaginase activity
H845_RS11225	COG2814	Major facilitator Superfamily
H845_RS11235	COG3961	Belongs to the TPP enzyme family
H845_RS11240	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H845_RS11250	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H845_RS11255	COG0574	Belongs to the PEP-utilizing enzyme family
H845_RS11255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H845_RS11275	COG2423	ornithine cyclodeaminase activity
H845_RS11280	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H845_RS11285	COG2814	Major facilitator Superfamily
H845_RS11300	COG1959	2 iron, 2 sulfur cluster binding
H845_RS11305	COG1012	belongs to the aldehyde dehydrogenase family
H845_RS11325	COG0584	glycerophosphoryl diester phosphodiesterase
H845_RS11345	COG3189	MarR family transcriptional regulator
H845_RS11355	COG0488	(ABC) transporter
H845_RS11365	COG1937	Protein conserved in bacteria
H845_RS11375	COG2132	Multicopper oxidase
H845_RS11450	COG1657	PFAM Prenyltransferase squalene oxidase
H845_RS11505	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H845_RS11510	COG0363	glucosamine-6-phosphate deaminase activity
H845_RS11520	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H845_RS11525	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H845_RS11545	COG2963	transposase activity
H845_RS11550	COG2801	Transposase and inactivated derivatives
H845_RS11555	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H845_RS11575	COG0436	Aminotransferase
H845_RS11585	COG1126	abc transporter atp-binding protein
H845_RS11590	COG0765	amino acid transport
H845_RS11595	COG4597	amino acid ABC transporter
H845_RS11600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H845_RS11615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H845_RS11625	COG1979	alcohol dehydrogenase
H845_RS11640	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H845_RS11645	COG0583	DNA-binding transcription factor activity
H845_RS11650	COG0596	Alpha beta hydrolase
H845_RS11660	COG0625	glutathione transferase activity
H845_RS11670	COG2814	Major facilitator Superfamily
H845_RS11675	COG0596	Alpha beta hydrolase
H845_RS11680	COG1309	transcriptional regulator
H845_RS11690	COG1309	transcriptional regulator
H845_RS11695	COG1028	Short-chain dehydrogenase reductase Sdr
H845_RS11705	COG0657	acetylesterase activity
H845_RS11710	COG1028	Short-chain dehydrogenase reductase Sdr
H845_RS11715	COG0583	DNA-binding transcription factor activity
H845_RS11730	COG1733	regulation of RNA biosynthetic process
H845_RS11775	COG3451	type IV secretory pathway VirB4
H845_RS11790	COG4962	Type ii secretion system protein e
H845_RS11815	COG2353	YceI-like domain
H845_RS11820	COG3038	cytochrome b561
H845_RS11825	COG2353	YceI-like domain
H845_RS11830	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H845_RS11860	COG0741	lytic transglycosylase activity
H845_RS11905	COG1476	TRANSCRIPTIONal
H845_RS11910	COG5489	Protein of unknown function (DUF736)
H845_RS11930	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H845_RS11935	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H845_RS11945	COG4974	Belongs to the 'phage' integrase family
H845_RS11965	COG1733	regulation of RNA biosynthetic process
H845_RS12020	COG0131	Imidazoleglycerol-phosphate dehydratase
H845_RS12030	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H845_RS12035	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H845_RS12040	COG0107	imidazoleglycerol-phosphate synthase activity
H845_RS12045	COG0140	phosphoribosyl-ATP diphosphatase activity
H845_RS12055	COG5265	(ABC) transporter
H845_RS12060	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H845_RS12070	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H845_RS12075	COG0540	Belongs to the ATCase OTCase family
H845_RS12080	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H845_RS12085	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H845_RS12090	COG0758	DNA mediated transformation
H845_RS12095	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H845_RS12100	COG0557	exoribonuclease II activity
H845_RS12105	COG0793	Belongs to the peptidase S41A family
H845_RS12105	COG3409	Peptidoglycan-binding domain 1 protein
H845_RS12115	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H845_RS12115	COG2885	chlorophyll binding
H845_RS12120	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H845_RS12125	COG1959	2 iron, 2 sulfur cluster binding
H845_RS12140	COG0187	DNA topoisomerase II activity
H845_RS12150	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H845_RS12160	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H845_RS12165	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H845_RS12170	COG0196	riboflavin kinase activity
H845_RS12175	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
H845_RS12180	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
H845_RS12185	COG0235	Class ii aldolase
H845_RS12190	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H845_RS12200	COG2137	regulation of response to DNA damage stimulus
H845_RS12205	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H845_RS12210	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H845_RS12230	COG4232	protein-disulfide reductase activity
H845_RS12235	COG1643	Atp-dependent helicase
H845_RS12270	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H845_RS12275	COG0859	PFAM glycosyl transferase family 9
H845_RS12300	COG0717	Belongs to the dCTP deaminase family
H845_RS12305	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H845_RS12310	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H845_RS12315	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H845_RS12320	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H845_RS12325	COG0424	maF-like protein
H845_RS12330	COG1530	ribonuclease E activity
H845_RS12345	COG2200	EAL domain
H845_RS12345	COG2199	diguanylate cyclase activity
H845_RS12345	COG2202	Pas domain
H845_RS12350	COG2202	Pas domain
H845_RS12350	COG2199	diguanylate cyclase activity
H845_RS12350	COG2200	EAL domain
H845_RS12380	COG0740	serine-type endopeptidase activity
H845_RS12390	COG0436	Aminotransferase
H845_RS12425	COG4303	Ethanolamine ammonia lyase large subunit
H845_RS12435	COG0531	amino acid
H845_RS12450	COG1228	amidohydrolase
H845_RS12450	COG1228	amidohydrolase
H845_RS12480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H845_RS12505	COG0438	transferase activity, transferring glycosyl groups
H845_RS12530	COG2176	DNA-directed DNA polymerase activity
H845_RS12545	COG1132	(ABC) transporter
H845_RS12555	COG1321	iron dependent repressor
H845_RS12565	COG0450	alkyl hydroperoxide reductase
H845_RS12575	COG0446	pyridine nucleotide-disulphide oxidoreductase
H845_RS12585	COG1028	Short-chain dehydrogenase reductase Sdr
H845_RS12590	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H845_RS12625	COG0352	thiamine-phosphate diphosphorylase activity
H845_RS12625	COG0351	phosphomethylpyrimidine kinase
H845_RS12630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H845_RS12635	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H845_RS12650	COG0037	tRNA processing
H845_RS12660	COG2885	chlorophyll binding
H845_RS12665	COG0823	Involved in the tonB-independent uptake of proteins
H845_RS12675	COG0848	biopolymer transport protein
H845_RS12685	COG0824	Thioesterase
H845_RS12690	COG2255	four-way junction helicase activity
H845_RS12695	COG0632	four-way junction helicase activity
H845_RS12700	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H845_RS12705	COG0217	transcriptional regulatory protein
H845_RS12710	COG0653	protein targeting
H845_RS12715	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H845_RS12720	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H845_RS12725	COG1714	RDD family
H845_RS12730	COG0668	transmembrane transport
H845_RS12750	COG1127	ABC transporter
H845_RS12780	COG2967	ApaG domain
H845_RS12785	COG0302	gtp cyclohydrolase
H845_RS12795	COG0521	Mo-molybdopterin cofactor biosynthetic process
H845_RS12815	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H845_RS12825	COG3961	Belongs to the TPP enzyme family
H845_RS12830	COG0277	FAD linked oxidase domain protein
H845_RS12845	COG3527	Alpha-acetolactate decarboxylase
H845_RS12860	COG0484	heat shock protein binding
H845_RS12865	COG0025	NhaP-type Na H and K H
H845_RS12915	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H845_RS12925	COG1573	uracil-dna glycosylase
H845_RS12935	COG1253	flavin adenine dinucleotide binding
H845_RS12945	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H845_RS12965	COG3394	polysaccharide catabolic process
H845_RS12970	COG3118	belongs to the thioredoxin family
H845_RS12975	COG1074	ATP-dependent DNA helicase activity
H845_RS12980	COG2887	Belongs to the helicase family. UvrD subfamily
H845_RS12985	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H845_RS12995	COG0492	ferredoxin-NADP+ reductase activity
H845_RS13000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H845_RS13010	COG1217	gtp-binding protein TYPA
H845_RS13015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H845_RS13030	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H845_RS13035	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H845_RS13040	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H845_RS13045	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H845_RS13050	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H845_RS13055	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H845_RS13060	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H845_RS13080	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H845_RS13100	COG2995	paraquat-inducible protein a
H845_RS13160	COG0347	Belongs to the P(II) protein family
H845_RS13165	COG0004	ammonium transporteR
H845_RS13210	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H845_RS13210	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H845_RS13230	COG2199	diguanylate cyclase activity
H845_RS13230	COG2202	Pas domain
H845_RS13230	COG2200	EAL domain
H845_RS13260	COG0656	L-ascorbic acid biosynthetic process
H845_RS13270	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H845_RS13285	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H845_RS13360	COG2963	transposase activity
H845_RS13405	COG3293	Transposase
H845_RS13440	COG0662	Cupin 2, conserved barrel domain protein
H845_RS13440	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H845_RS13465	COG1215	transferase activity, transferring glycosyl groups
H845_RS13550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H845_RS13565	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H845_RS13570	COG0251	oxidation-reduction process
H845_RS13580	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H845_RS13585	COG0799	negative regulation of ribosome biogenesis
H845_RS13590	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H845_RS13595	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H845_RS13600	COG0012	GTP binding
H845_RS13605	COG0193	aminoacyl-tRNA hydrolase activity
H845_RS13610	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H845_RS13615	COG0406	alpha-ribazole phosphatase activity
H845_RS13620	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H845_RS13630	COG1496	oxidoreductase activity
H845_RS13640	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H845_RS13650	COG2960	long-chain fatty acid transporting porin activity
H845_RS13680	COG2308	Evidence 4 Homologs of previously reported genes of
H845_RS13705	COG0247	lactate metabolic process
H845_RS13725	COG3335	DDE superfamily endonuclease
H845_RS13745	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H845_RS13750	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H845_RS13755	COG1877	trehalose-phosphatase activity
H845_RS13780	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H845_RS13825	COG0481	GTPase activity
H845_RS13895	COG2982	Protein involved in outer membrane biogenesis
H845_RS13900	COG0129	dihydroxy-acid dehydratase activity
H845_RS13930	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H845_RS13935	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H845_RS13970	COG1028	Short-chain dehydrogenase reductase Sdr
H845_RS13970	COG3321	synthase
H845_RS13970	COG0604	alcohol dehydrogenase
H845_RS13985	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H845_RS13990	COG1692	metallophosphoesterase
H845_RS13995	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H845_RS14015	COG0352	thiamine-phosphate diphosphorylase activity
H845_RS14020	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H845_RS14030	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H845_RS14035	COG0483	inositol monophosphate 1-phosphatase activity
H845_RS14060	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H845_RS14065	COG0583	DNA-binding transcription factor activity
H845_RS14070	COG0450	alkyl hydroperoxide reductase
H845_RS14075	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H845_RS14085	COG1902	pentaerythritol trinitrate reductase activity
H845_RS14110	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H845_RS14115	COG3265	gluconokinase activity
H845_RS14120	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H845_RS14125	COG0363	glucosamine-6-phosphate deaminase activity
H845_RS14135	COG0561	phosphatase activity
H845_RS14145	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H845_RS14150	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H845_RS14175	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H845_RS14185	COG2814	Major facilitator Superfamily
H845_RS14200	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
H845_RS14215	COG0246	Mannitol dehydrogenase
H845_RS14240	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H845_RS14250	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H845_RS14255	COG0343	queuine tRNA-ribosyltransferase activity
H845_RS14260	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H845_RS14270	COG1881	PFAM PEBP family protein
H845_RS14290	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
H845_RS14295	COG2853	Lipoprotein
H845_RS14310	COG0488	(ABC) transporter
H845_RS14320	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H845_RS14350	COG2274	protein secretion by the type I secretion system
H845_RS14360	COG1410	methionine synthase
H845_RS14360	COG0646	methionine synthase
H845_RS14365	COG0140	phosphoribosyl-ATP diphosphatase activity
H845_RS14375	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H845_RS14380	COG1028	Short-chain dehydrogenase reductase Sdr
H845_RS14385	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H845_RS14395	COG3293	Transposase
H845_RS14415	COG1570	exodeoxyribonuclease VII activity
H845_RS14425	COG2814	Major facilitator Superfamily
H845_RS14430	COG2233	PERMEase
H845_RS14460	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H845_RS14470	COG4974	Belongs to the 'phage' integrase family
H845_RS14475	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H845_RS14485	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H845_RS14490	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H845_RS14495	COG0778	Nitroreductase
H845_RS14500	COG0604	alcohol dehydrogenase
H845_RS14550	COG2099	Precorrin-6x reductase
H845_RS14570	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
H845_RS14575	COG1797	cobyrinic acid a,c-diamide synthase activity
H845_RS14585	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
H845_RS14585	COG1918	ferrous iron import across plasma membrane
H845_RS14595	COG2200	EAL domain
H845_RS14595	COG2202	Pas domain
H845_RS14595	COG2199	diguanylate cyclase activity
H845_RS14605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H845_RS14610	COG0508	dehydrogenase complex catalyzes the overall conversion of
H845_RS14620	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H845_RS14625	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H845_RS14645	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H845_RS14650	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H845_RS14665	COG1053	succinate dehydrogenase
H845_RS14670	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H845_RS14680	COG1396	sequence-specific DNA binding
H845_RS14685	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H845_RS14715	COG0778	Nitroreductase
H845_RS14755	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H845_RS14760	COG0667	Aldo Keto reductase
H845_RS14765	COG1420	regulation of RNA biosynthetic process
H845_RS14770	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H845_RS14775	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H845_RS14785	COG0542	response to heat
H845_RS14795	COG0779	Required for maturation of 30S ribosomal subunits
H845_RS14810	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H845_RS14810	COG5373	membrane
H845_RS14815	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H845_RS14825	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H845_RS14830	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H845_RS14835	COG1185	polyribonucleotide nucleotidyltransferase activity
H845_RS14845	COG0583	DNA-binding transcription factor activity
H845_RS14850	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H845_RS14855	COG4133	protoheme IX ABC transporter activity
H845_RS14860	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H845_RS14870	COG0019	diaminopimelate decarboxylase activity
H845_RS14875	COG1295	ribonuclease BN
H845_RS14880	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H845_RS14885	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H845_RS14890	COG0511	ligase activity, forming carbon-carbon bonds
H845_RS14895	COG0439	Biotin carboxylase
H845_RS14900	COG1289	transmembrane transporter activity
H845_RS14905	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H845_RS14910	COG2814	Major facilitator Superfamily
H845_RS14920	COG1612	heme a metabolic process
H845_RS14935	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H845_RS14940	COG1194	a g-specific adenine glycosylase
H845_RS14955	COG0135	phosphoribosylanthranilate isomerase activity
H845_RS14960	COG0284	orotidine-5'-phosphate decarboxylase activity
H845_RS14980	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H845_RS14985	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H845_RS14990	COG0312	modulator of DNA gyrase
H845_RS15050	COG0463	Glycosyl transferase, family 2
H845_RS15080	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H845_RS15085	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H845_RS15090	COG0590	tRNA wobble adenosine to inosine editing
H845_RS15105	COG0564	pseudouridine synthase activity
H845_RS15110	COG1674	ftsk spoiiie
H845_RS15120	COG1187	pseudouridine synthase activity
H845_RS15125	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H845_RS15145	COG0357	Ribosomal RNA small subunit methyltransferase G
H845_RS15150	COG0445	tRNA wobble uridine modification
H845_RS15155	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H845_RS15170	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H845_RS15185	COG0598	Magnesium transport protein CorA
H845_RS15190	COG0133	tryptophan synthase activity
H845_RS15195	COG0159	tryptophan synthase activity
H845_RS15200	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H845_RS15205	COG0285	dihydrofolate synthase activity
H845_RS15210	COG2814	Major facilitator Superfamily
H845_RS15230	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H845_RS15235	COG1250	3-hydroxyacyl-CoA dehydrogenase
H845_RS15235	COG1024	Enoyl-CoA hydratase
H845_RS15240	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H845_RS15245	COG2814	Major facilitator Superfamily
H845_RS15260	COG1028	Short-chain dehydrogenase reductase Sdr
H845_RS15280	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H845_RS15285	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H845_RS15290	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H845_RS15295	COG0484	heat shock protein binding
H845_RS15300	COG0443	Heat shock 70 kDa protein
H845_RS15310	COG0745	RESPONSE REGULATOR receiver
H845_RS15315	COG2205	protein histidine kinase activity
H845_RS15320	COG0535	radical SAM domain protein
H845_RS15330	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
H845_RS15335	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H845_RS15350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H845_RS15360	COG3047	cAMP biosynthetic process
H845_RS15365	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H845_RS15380	COG2086	electron transfer activity
H845_RS15405	COG0424	maF-like protein
H845_RS15410	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H845_RS15415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H845_RS15420	COG1981	membrane
H845_RS15450	COG1660	Displays ATPase and GTPase activities
H845_RS15455	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H845_RS15460	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H845_RS15465	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H845_RS15465	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H845_RS15480	COG0138	bifunctional purine biosynthesis protein purh
H845_RS15495	COG0356	it plays a direct role in the translocation of protons across the membrane
H845_RS15500	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H845_RS15505	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H845_RS15510	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H845_RS15520	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H845_RS15525	COG0673	inositol 2-dehydrogenase activity
H845_RS15545	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H845_RS15550	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H845_RS15565	COG0300	oxidoreductase activity
H845_RS15570	COG0194	GDP metabolic process
H845_RS15575	COG2814	Major facilitator Superfamily
H845_RS15580	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H845_RS15585	COG1127	ABC transporter
H845_RS15615	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H845_RS15620	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H845_RS15620	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H845_RS15660	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H845_RS15675	COG0469	pyruvate kinase activity
H845_RS15680	COG0287	Prephenate dehydrogenase
H845_RS15690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H845_RS15700	COG1562	ergosterol biosynthetic process
H845_RS15705	COG1562	ergosterol biosynthetic process
H845_RS15710	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
H845_RS15725	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H845_RS15755	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
H845_RS16045	COG3842	ATPase activity
H845_RS16105	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H845_RS16170	COG0542	response to heat
H845_RS16415	COG1566	PFAM secretion protein HlyD family protein
H845_RS16535	COG0542	response to heat
H845_RS16540	COG0542	response to heat
H845_RS16825	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H845_RS16825	COG0446	pyridine nucleotide-disulphide oxidoreductase
H845_RS17010	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H845_RS17240	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H845_RS17240	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H845_RS17245	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H845_RS17245	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H845_RS17305	COG0114	fumarate hydratase activity
H845_RS17340	COG0415	Belongs to the DNA photolyase family
H845_RS17385	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H845_RS17470	COG2202	Pas domain
H845_RS17470	COG2199	diguanylate cyclase activity
H845_RS17470	COG2200	EAL domain
H845_RS17785	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H845_RS17865	COG3706	GGDEF domain
H845_RS17870	COG5001	Diguanylate cyclase
H845_RS17870	COG3300	MHYT domain
H845_RS17910	COG0495	leucyl-tRNA aminoacylation
H845_RS17915	COG0495	leucyl-tRNA aminoacylation
H845_RS18040	COG4774	siderophore transport
H845_RS18080	COG1074	ATP-dependent DNA helicase activity