locus-tag class description IMCC3317_RS00020 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) IMCC3317_RS00070 ENOG4105WAB arsR family transcriptional regulator IMCC3317_RS00100 ENOG4105KNA -acetyltransferase IMCC3317_RS00145 ENOG4108R99 pseudouridine synthase IMCC3317_RS00170 ENOG4105CK7 Sodium proline symporter IMCC3317_RS00190 ENOG4105C1G acyl-Coa dehydrogenase IMCC3317_RS00200 ENOG4105CHU acetyl-coa acetyltransferase IMCC3317_RS00225 ENOG4108IQE Amp-dependent synthetase and ligase IMCC3317_RS00250 ENOG4105FFC UPF0187 protein IMCC3317_RS00255 ENOG4108V9Q carbonic anhydrase IMCC3317_RS00260 ENOG4105C9Q fumarate hydratase class II IMCC3317_RS00290 ENOG4105C5H ABC transporter IMCC3317_RS00305 ENOG4105EHG Permease protein IMCC3317_RS00315 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) IMCC3317_RS00325 ENOG4105EMN RNA polymerase sigma factor IMCC3317_RS00350 ENOG4107QTF adenylosuccinate lyase IMCC3317_RS00370 ENOG4105CMM transposase IMCC3317_RS00375 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) IMCC3317_RS00385 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase IMCC3317_RS00400 ENOG4107T9C Alpha amylase catalytic region IMCC3317_RS00410 ENOG4105C1J atp-dependent rna helicase IMCC3317_RS00420 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) IMCC3317_RS00430 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) IMCC3317_RS00475 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein IMCC3317_RS00480 ENOG4108TZV Membrane IMCC3317_RS00490 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) IMCC3317_RS00505 ENOG4108MJ3 acetyltransferase IMCC3317_RS00510 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) IMCC3317_RS00515 ENOG4108URH decarboxylase IMCC3317_RS00540 ENOG4106N3A copper homeostasis protein cutc IMCC3317_RS00555 ENOG4105E2D ec 3.2.1.52 IMCC3317_RS00560 ENOG4105CWX Alpha-1,2-mannosidase IMCC3317_RS00575 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) IMCC3317_RS00595 ENOG4105CGH 5'-nucleotidase IMCC3317_RS00610 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) IMCC3317_RS00635 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) IMCC3317_RS00640 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH IMCC3317_RS00680 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) IMCC3317_RS00700 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) IMCC3317_RS00705 ENOG4105EYW Ion transport protein IMCC3317_RS00715 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) IMCC3317_RS00720 ENOG4105DFA alanine racemase domain protein IMCC3317_RS00740 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase IMCC3317_RS00760 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) IMCC3317_RS00765 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) IMCC3317_RS00780 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) IMCC3317_RS00790 ENOG4108IG5 Transcriptional regulator IMCC3317_RS00800 ENOG4105DWT malate dehydrogenase (quinone) IMCC3317_RS00820 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit IMCC3317_RS00845 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) IMCC3317_RS00890 ENOG4105ENE Histidine kinase IMCC3317_RS00895 ENOG4105WH1 Two component transcriptional regulator luxr family IMCC3317_RS00910 ENOG4105E1F short-chain dehydrogenase reductase IMCC3317_RS00930 ENOG4105VYA Uncharacterized conserved protein (DUF2132) IMCC3317_RS00940 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) IMCC3317_RS00950 ENOG4105C5H ABC transporter IMCC3317_RS00970 ENOG4105DY9 regulatoR IMCC3317_RS00975 ENOG4108HRK Histidine kinase IMCC3317_RS01000 ENOG4108K8S endonuclease I IMCC3317_RS01035 ENOG4105FQP Beta-lactamase IMCC3317_RS01050 ENOG4105C7K acetolactate synthase IMCC3317_RS01095 ENOG4105D8V Glucose sorbosone dehydrogenase IMCC3317_RS01135 ENOG4108HRK Histidine kinase IMCC3317_RS01140 ENOG4108VAC response regulator IMCC3317_RS01155 ENOG4105CBC glutamate synthase IMCC3317_RS01160 ENOG4105CH2 amidohydrolase IMCC3317_RS01190 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen IMCC3317_RS01195 ENOG4105EDV vault protein IMCC3317_RS01205 ENOG4107RTD sua5 ycio yrdc ywlc family protein IMCC3317_RS01210 ENOG4105HHA aminodeoxychorismate lyase IMCC3317_RS01215 ENOG4105DNP FAD linked oxidase domain protein IMCC3317_RS01300 ENOG4105VMP Transcriptional regulator IMCC3317_RS01320 ENOG4105CPP Dehydrogenase, E1 component IMCC3317_RS01355 ENOG4108URH decarboxylase IMCC3317_RS01380 ENOG4107VE4 peptidase S8 and S53, subtilisin, kexin, sedolisin IMCC3317_RS01410 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) IMCC3317_RS01425 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) IMCC3317_RS01440 ENOG4105VPI YqaE family transport protein IMCC3317_RS01465 ENOG4107QX9 Thiol disulfide interChange protein IMCC3317_RS01475 ENOG4105CQB FAD linked oxidase domain protein IMCC3317_RS01485 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase IMCC3317_RS01500 ENOG4105D7Z glutathione synthase IMCC3317_RS01545 ENOG4107MM9 BNR Asp-box repeat-containing protein IMCC3317_RS01550 ENOG4107XM9 (LipO)protein IMCC3317_RS01555 ENOG4107XM9 (LipO)protein IMCC3317_RS01595 ENOG4105BZU Histidine kinase IMCC3317_RS01705 ENOG4108KB1 transcriptional regulator, arac family IMCC3317_RS01755 ENOG4108VVK transcriptional Regulator, AsnC IMCC3317_RS01760 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) IMCC3317_RS01785 ENOG4105D49 3-dehydroquinate synthase IMCC3317_RS01830 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family IMCC3317_RS01835 ENOG4105DCI Phosphohydrolase IMCC3317_RS01840 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) IMCC3317_RS01845 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) IMCC3317_RS01850 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) IMCC3317_RS01855 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) IMCC3317_RS01860 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) IMCC3317_RS01865 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha IMCC3317_RS01875 ENOG4105CHR reductase IMCC3317_RS01900 ENOG41080PD NADH ubiquinone oxidoreductase 41 kD complex I subunit IMCC3317_RS01910 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) IMCC3317_RS01915 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) IMCC3317_RS01920 ENOG4105CIH Imidazole acetol-phosphate transaminase IMCC3317_RS01925 ENOG4105ECC imidazole-glycerol-phosphate dehydratase IMCC3317_RS01935 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase IMCC3317_RS01940 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) IMCC3317_RS01945 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase IMCC3317_RS01955 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) IMCC3317_RS01965 ENOG4105C1J atp-dependent rna helicase IMCC3317_RS01980 ENOG4107YHX fad dependent oxidoreductase IMCC3317_RS02005 ENOG4105C3G gtp-binding protein IMCC3317_RS02020 ENOG4105DNX Dna topoisomerase iv (Subunit b) IMCC3317_RS02030 ENOG4105DF5 DNA topoisomerase IV, subunit A IMCC3317_RS02055 ENOG4105KIR Thiol-disulfide oxidoreductase dcc IMCC3317_RS02060 ENOG4105C98 muts2 protein IMCC3317_RS02065 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) IMCC3317_RS02080 ENOG4105D3A purine nucleoside phosphorylase DeoD-type IMCC3317_RS02100 ENOG4105CPP Dehydrogenase, E1 component IMCC3317_RS02160 ENOG4108K5P (LipO)protein IMCC3317_RS02165 ENOG4105DR5 peptidase IMCC3317_RS02180 ENOG4105DNP FAD linked oxidase domain protein IMCC3317_RS02185 ENOG4105VEQ Cold shock protein IMCC3317_RS02190 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) IMCC3317_RS02195 ENOG4105VEQ Cold shock protein IMCC3317_RS02205 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase IMCC3317_RS02210 ENOG4105DQ4 alcohol dehydrogenase IMCC3317_RS02270 ENOG4105VEQ Cold shock protein IMCC3317_RS02285 ENOG4105VEQ Cold shock protein IMCC3317_RS02310 ENOG4105C1J atp-dependent rna helicase IMCC3317_RS02325 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) IMCC3317_RS02330 ENOG4105UYK outer membrane protein a IMCC3317_RS02335 ENOG4107R6F Alpha Beta Hydrolase Fold protein IMCC3317_RS02340 ENOG4108MJI response regulator IMCC3317_RS02355 ENOG4105D5T phosphonate abc transporter IMCC3317_RS02390 ENOG4105BZ1 (ABC) transporter IMCC3317_RS02415 ENOG4105KVH Transcriptional regulator IMCC3317_RS02430 ENOG4108HRK Histidine kinase IMCC3317_RS02435 ENOG4105FQP Beta-lactamase IMCC3317_RS02460 ENOG4105C2C drug resistance transporter, Bcr CflA IMCC3317_RS02495 ENOG4105CNG UPF0061 protein IMCC3317_RS02505 ENOG4109015 Biopolymer transport protein exbD tolR IMCC3317_RS02550 ENOG4105C1J atp-dependent rna helicase IMCC3317_RS02560 ENOG4108Q35 Adenylate IMCC3317_RS02565 ENOG4105VZ8 Transcriptional regulator IMCC3317_RS02595 ENOG4108S4H thioesterase Superfamily protein IMCC3317_RS02625 ENOG4108Z7R Chaperone CsaA IMCC3317_RS02640 ENOG4108YYS metal-dependent hydrolase (By similarity) IMCC3317_RS02645 ENOG4107XH4 PPIases accelerate the folding of proteins (By similarity) IMCC3317_RS02655 ENOG4105BZU Histidine kinase IMCC3317_RS02660 ENOG4105WH1 Two component transcriptional regulator luxr family IMCC3317_RS02665 ENOG4105C9U ATP-dependent DNA helicase RecQ IMCC3317_RS02670 ENOG4105C2X Arabinose 5-phosphate isomerase IMCC3317_RS02675 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) IMCC3317_RS02685 ENOG4108IUZ ABC transporter IMCC3317_RS02720 ENOG4107T8Q Glycosyl transferase (Group 1 IMCC3317_RS02745 ENOG4105CG5 Glycosyl transferase (Group 1 IMCC3317_RS02765 ENOG4108RYC glycosyltransferase IMCC3317_RS02790 ENOG4105F0R Cytidylyltransferase IMCC3317_RS02795 ENOG4107SE4 UDP-N-acetylglucosamine 2-epimerase IMCC3317_RS02805 ENOG4105D2T synthase IMCC3317_RS02815 ENOG41083B3 HAD-superfamily subfamily IB hydrolase IMCC3317_RS02830 ENOG4106YN8 Prenyltransferase IMCC3317_RS02845 ENOG4105EY8 ABC transporter IMCC3317_RS02870 ENOG4105D75 Capsular exopolysaccharide family IMCC3317_RS02880 ENOG4105C5H ABC transporter IMCC3317_RS02920 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving IMCC3317_RS02930 ENOG4105EMN RNA polymerase sigma factor IMCC3317_RS02960 ENOG4105BZU Histidine kinase IMCC3317_RS02965 ENOG4105WH1 Two component transcriptional regulator luxr family IMCC3317_RS02980 ENOG4105JVQ RNA Polymerase IMCC3317_RS02985 ENOG4105DJT lAO AO transport system ATPase IMCC3317_RS03045 ENOG4107QWK SAICAR synthetase IMCC3317_RS03050 ENOG4105C9A Phoh family IMCC3317_RS03055 ENOG4107V4F S-adenosyl-l-methionine hydroxide adenosyltransferase IMCC3317_RS03075 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) IMCC3317_RS03085 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) IMCC3317_RS03135 ENOG4107QMZ Dehydrogenase IMCC3317_RS03140 ENOG4105CTU Proline racemase IMCC3317_RS03150 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) IMCC3317_RS03180 ENOG4107VXZ Hydrolase IMCC3317_RS03190 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) IMCC3317_RS03195 ENOG4108K8S endonuclease I IMCC3317_RS03200 ENOG4105ETE Transcriptional regulator (LacI family IMCC3317_RS03220 ENOG4105CT4 transporter IMCC3317_RS03260 ENOG4105C27 TonB-dependent Receptor Plug IMCC3317_RS03270 ENOG4105CUY Mechanosensitive ion channel IMCC3317_RS03290 ENOG4105EKX Restriction modification system DNA (Specificity IMCC3317_RS03315 ENOG4108MN8 Membrane IMCC3317_RS03320 ENOG4105E0X reductase IMCC3317_RS03325 ENOG4105CPK Glycosyl transferase (Group 1 IMCC3317_RS03330 ENOG4105D17 glycoside hydrolase, family 3 domain protein IMCC3317_RS03350 ENOG4105DF6 Fe-S oxidoreductase IMCC3317_RS03355 ENOG4105DF6 Fe-S oxidoreductase IMCC3317_RS03360 ENOG4107KIA Virulence factor Mce family protein IMCC3317_RS03365 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase IMCC3317_RS03375 ENOG4105KME endoribonuclease L-psp IMCC3317_RS03430 ENOG4105CYX Short-chain dehydrogenase reductase Sdr IMCC3317_RS03440 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) IMCC3317_RS03470 ENOG4105C26 Dehydrogenase IMCC3317_RS03495 ENOG4105WH1 Two component transcriptional regulator luxr family IMCC3317_RS03500 ENOG4105BZU Histidine kinase IMCC3317_RS03525 ENOG4105P4J Allophanate hydrolase, subunit 1 IMCC3317_RS03535 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) IMCC3317_RS03575 ENOG4107RCM Releases the N-terminal proline from various substrates (By similarity) IMCC3317_RS03585 ENOG4105IBP Cyclic peptide transporter IMCC3317_RS03620 ENOG4105C0W non-ribosomal peptide synthetase IMCC3317_RS03635 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) IMCC3317_RS03650 ENOG4108JA1 polyketide synthase IMCC3317_RS03740 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase IMCC3317_RS03755 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) IMCC3317_RS03785 ENOG4105CEY Amp-dependent synthetase and ligase IMCC3317_RS03795 ENOG4105IBP Cyclic peptide transporter IMCC3317_RS03815 ENOG4105C6T cysteine synthase IMCC3317_RS03820 ENOG4105JZC GHMP kinase IMCC3317_RS03920 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) IMCC3317_RS03945 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) IMCC3317_RS03950 ENOG4105EHZ conserved protein UCP016719 IMCC3317_RS03960 ENOG4105C0P Mg chelatase subunit ChlI IMCC3317_RS03965 ENOG4105WH1 Two component transcriptional regulator luxr family IMCC3317_RS03970 ENOG4105BZU Histidine kinase IMCC3317_RS04005 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) IMCC3317_RS04095 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) IMCC3317_RS04100 ENOG4105WH1 Two component transcriptional regulator luxr family IMCC3317_RS04145 ENOG4107THF Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) IMCC3317_RS04240 ENOG4105C7R Atpase associated with various cellular activities aaa_3 IMCC3317_RS04245 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) IMCC3317_RS04255 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) IMCC3317_RS04280 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) IMCC3317_RS04310 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) IMCC3317_RS04315 ENOG4105C27 TonB-dependent Receptor Plug IMCC3317_RS04320 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) IMCC3317_RS04330 ENOG4105VIE preprotein translocase, subunit YajC IMCC3317_RS04340 ENOG4107R6T Involved in the transcription termination process (By similarity) IMCC3317_RS04350 ENOG4105BZ1 (ABC) transporter IMCC3317_RS04360 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding IMCC3317_RS04370 ENOG4105CZ9 Domain of unknown function (DU1801) IMCC3317_RS04375 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) IMCC3317_RS04380 ENOG4108JQ1 Dehydrogenase IMCC3317_RS04415 ENOG4105D05 Receptor IMCC3317_RS04445 ENOG4105EUJ GTP cyclohydrolase i IMCC3317_RS04470 ENOG4105DZ0 fad dependent oxidoreductase IMCC3317_RS04480 ENOG4107YHX fad dependent oxidoreductase IMCC3317_RS04520 ENOG4105CD3 dihydroorotase IMCC3317_RS04565 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen IMCC3317_RS04570 ENOG4105CSM endonuclease III IMCC3317_RS04580 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) IMCC3317_RS04640 ENOG4105CUT histidyl-tRNA synthetase IMCC3317_RS04660 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein IMCC3317_RS04675 ENOG4105K9Q Binds to the 23S rRNA (By similarity) IMCC3317_RS04680 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) IMCC3317_RS04685 ENOG41080B9 Binds together with S18 to 16S ribosomal RNA (By similarity) IMCC3317_RS04690 ENOG4105DY9 regulatoR IMCC3317_RS04695 ENOG4105C25 Primosomal protein n' IMCC3317_RS04710 ENOG4107U9T Pfam:Ribonuclease_BN IMCC3317_RS04715 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase IMCC3317_RS04720 ENOG4108Z6B deaminase IMCC3317_RS04745 ENOG4105C59 p-type ATPase IMCC3317_RS04770 ENOG4108IJF Heavy metal efflux pump, CzcA IMCC3317_RS04785 ENOG4105C59 p-type ATPase IMCC3317_RS04795 ENOG4105BZU Histidine kinase IMCC3317_RS04800 ENOG4105XJC Two component transcriptional regulator (Winged helix family IMCC3317_RS04810 ENOG4107YZX Universal stress protein IMCC3317_RS04820 ENOG4107YZX Universal stress protein IMCC3317_RS04845 ENOG4105CY0 Metallo-Beta-Lactamase IMCC3317_RS04860 ENOG4105H9W Short-chain dehydrogenase reductase Sdr IMCC3317_RS04865 ENOG4105DPW Major facilitator superfamily MFS_1 IMCC3317_RS04870 ENOG4107YCY Transcriptional regulator IMCC3317_RS04885 ENOG4105TT1 Ragb susd domain-containing protein IMCC3317_RS04890 ENOG4105C27 TonB-dependent Receptor Plug IMCC3317_RS04950 ENOG4105FJR Lmbe family IMCC3317_RS04960 ENOG4105C28 cystathionine IMCC3317_RS04965 ENOG4108V06 Glutathione peroxidase IMCC3317_RS05000 ENOG4108HRK Histidine kinase IMCC3317_RS05005 ENOG4108NEV two component transcriptional regulator, LytTR family IMCC3317_RS05010 ENOG4105CRE cytochrome C IMCC3317_RS05025 ENOG4105DS0 Transcriptional regulator, Crp Fnr family IMCC3317_RS05035 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase IMCC3317_RS05045 ENOG4108Z03 MAF-like protein IMCC3317_RS05115 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) IMCC3317_RS05135 ENOG4105CGD Nad-dependent epimerase dehydratase IMCC3317_RS05140 ENOG4105CVP deoxyribo-dipyrimidine photolyase IMCC3317_RS05155 ENOG4105EUJ GTP cyclohydrolase i IMCC3317_RS05165 ENOG4105CHR reductase IMCC3317_RS05180 ENOG4105CVP deoxyribo-dipyrimidine photolyase IMCC3317_RS05190 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) IMCC3317_RS05200 ENOG4108D64 Protein of unknown function (DUF493) IMCC3317_RS05215 ENOG4105C9U ATP-dependent DNA helicase RecQ IMCC3317_RS05220 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) IMCC3317_RS05225 ENOG4105K70 DNA-binding protein IMCC3317_RS05395 ENOG4105BZ1 (ABC) transporter IMCC3317_RS05420 ENOG4105CUG Oligopeptidase b IMCC3317_RS05460 ENOG4105E2Y ABC, transporter IMCC3317_RS05470 ENOG4105D2X ABC transporter substrate-binding protein IMCC3317_RS05550 ENOG4105C9U ATP-dependent DNA helicase RecQ IMCC3317_RS05595 ENOG4105DU6 RNA polymerase IMCC3317_RS05600 ENOG4105E0A ABC, transporter IMCC3317_RS05610 ENOG4105CGY Dna recombination protein IMCC3317_RS05650 ENOG4105NAU thioesterase Superfamily protein IMCC3317_RS05710 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain IMCC3317_RS05715 ENOG4105VG0 50S ribosomal protein l34 IMCC3317_RS05780 ENOG4105DTQ mandelate racemase muconate lactonizing IMCC3317_RS05785 ENOG4107W2A UPF0173 metal-dependent hydrolase IMCC3317_RS05795 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase IMCC3317_RS05830 ENOG4105QNR S1 RNA binding domain protein IMCC3317_RS05850 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) IMCC3317_RS05855 ENOG4105E4F Isochorismate synthase IMCC3317_RS05860 ENOG4105KA0 thioesterase Superfamily protein IMCC3317_RS05870 ENOG4105C9U ATP-dependent DNA helicase RecQ IMCC3317_RS05880 ENOG4105CFG Acts as a chaperone (By similarity) IMCC3317_RS05885 ENOG4105EJQ L-serine dehydratase IMCC3317_RS05920 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) IMCC3317_RS05945 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) IMCC3317_RS05965 ENOG4105CTQ phosphohexokinase IMCC3317_RS05975 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) IMCC3317_RS06030 ENOG4105CKK Glycosyl transferase, family 2 IMCC3317_RS06125 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) IMCC3317_RS06140 ENOG41080WS Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) IMCC3317_RS06145 ENOG4105UYK outer membrane protein a IMCC3317_RS06175 ENOG4105K89 arsenate reductase IMCC3317_RS06210 ENOG4105GR3 Histidine kinase IMCC3317_RS06215 ENOG4105DY9 regulatoR IMCC3317_RS06245 ENOG4105C4X radical SAM domain protein IMCC3317_RS06300 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) IMCC3317_RS06310 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) IMCC3317_RS06335 ENOG4105ENE Histidine kinase IMCC3317_RS06340 ENOG4105WH1 Two component transcriptional regulator luxr family IMCC3317_RS06360 ENOG4105C7N Xanthine uracil vitamin C permease IMCC3317_RS06390 ENOG41087PP glycosyltransferase MGT family IMCC3317_RS06405 ENOG4105E5H Transposase IMCC3317_RS06440 ENOG4105CHU acetyl-coa acetyltransferase IMCC3317_RS06445 ENOG4107SN7 NLP P60 protein IMCC3317_RS06455 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) IMCC3317_RS06475 ENOG4105C84 Histidine ammonia-lyase IMCC3317_RS06480 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen IMCC3317_RS06485 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) IMCC3317_RS06490 ENOG4105CFH Aspartokinase IMCC3317_RS06495 ENOG4107RDY Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) IMCC3317_RS06500 ENOG4105D98 threonine synthase IMCC3317_RS06505 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) IMCC3317_RS06515 ENOG4105CN1 protease IMCC3317_RS06525 ENOG4105CDY transcriptional regulatory protein IMCC3317_RS06545 ENOG4105C6E dna polymerase iii IMCC3317_RS06570 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) IMCC3317_RS06580 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) IMCC3317_RS06600 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) IMCC3317_RS06610 ENOG4105CXT aspartate transcarbamylase IMCC3317_RS06615 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) IMCC3317_RS06650 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) IMCC3317_RS06660 ENOG4105CAT Cytidine monophosphate kinase IMCC3317_RS06685 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) IMCC3317_RS06710 ENOG4105DEU major facilitator superfamily IMCC3317_RS06735 ENOG4107R91 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) IMCC3317_RS06740 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) IMCC3317_RS06745 ENOG4107S9Q Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) IMCC3317_RS06750 ENOG4108I7H Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) IMCC3317_RS06840 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) IMCC3317_RS06845 ENOG4107QPH glycogen) synthase IMCC3317_RS06850 ENOG4105E0X reductase IMCC3317_RS06855 ENOG4108RG0 uracil-dna glycosylase IMCC3317_RS06875 ENOG4105DUX Transporter IMCC3317_RS06895 ENOG4107QN2 dihydrolipoyl dehydrogenase IMCC3317_RS06915 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) IMCC3317_RS06935 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) IMCC3317_RS06990 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase IMCC3317_RS06995 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase IMCC3317_RS07000 ENOG41062T2 Acyl carrier protein IMCC3317_RS07005 ENOG4108151 Beta-lactamase domain protein IMCC3317_RS07015 ENOG4108KQ6 Enoyl-CoA hydratase IMCC3317_RS07020 ENOG4108MGH Enoyl-CoA hydratase IMCC3317_RS07025 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase IMCC3317_RS07035 ENOG4105C0W non-ribosomal peptide synthetase IMCC3317_RS07040 ENOG4105C0W non-ribosomal peptide synthetase IMCC3317_RS07045 ENOG4107SQU synthase IMCC3317_RS07050 ENOG4105C0W non-ribosomal peptide synthetase IMCC3317_RS07055 ENOG4105C0W non-ribosomal peptide synthetase IMCC3317_RS07080 ENOG4105EE1 crotonyl-CoA reductase IMCC3317_RS07085 ENOG4105C0W non-ribosomal peptide synthetase IMCC3317_RS07100 ENOG4105C0W non-ribosomal peptide synthetase IMCC3317_RS07105 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) IMCC3317_RS07110 ENOG4107QI6 Cysteine desulfurase IMCC3317_RS07145 ENOG4105C8Y Acetylornithine aminotransferase IMCC3317_RS07165 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) IMCC3317_RS07230 ENOG4105KT5 UmuD protein IMCC3317_RS07235 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) IMCC3317_RS07280 ENOG4105BZ1 (ABC) transporter IMCC3317_RS07300 ENOG4105CBD Diacylglycerol kinase IMCC3317_RS07305 ENOG4105EYK Phosphatidylglycerophosphatase B IMCC3317_RS07310 ENOG4105DIJ Phosphoethanolamine transferase IMCC3317_RS07360 ENOG4105GR3 Histidine kinase IMCC3317_RS07365 ENOG4105EFQ Two component transcriptional regulator (Winged helix family IMCC3317_RS07400 ENOG4105D78 K07001 NTE family protein IMCC3317_RS07415 ENOG4105CEP NADH dehydrogenase IMCC3317_RS07425 ENOG4105E3B Multicopper oxidase IMCC3317_RS07455 ENOG4105CN9 Peptidase m42 family protein IMCC3317_RS07465 ENOG4105CSR polyphosphate kinase 2 IMCC3317_RS07480 ENOG4105EGS Mechanosensitive ion channel IMCC3317_RS07485 ENOG4105RHA ABC transporter, permease IMCC3317_RS07490 ENOG4108IUX (ABC) transporter IMCC3317_RS07495 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) IMCC3317_RS07500 ENOG4107XPB Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ IMCC3317_RS07515 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) IMCC3317_RS07525 ENOG4105CM2 brancheD-chain amino acid aminotransferase IMCC3317_RS07540 ENOG4105WH1 Two component transcriptional regulator luxr family IMCC3317_RS07550 ENOG4105BZU Histidine kinase IMCC3317_RS07560 ENOG4105CPN adenine deaminase IMCC3317_RS07580 ENOG41083GQ Protein CrcB homolog IMCC3317_RS07590 ENOG4105C6X Major Facilitator IMCC3317_RS07640 ENOG4105BZG amino acid carrier protein IMCC3317_RS07665 ENOG410600T transposase IMCC3317_RS07710 ENOG4108RCM Nitroreductase IMCC3317_RS07720 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) IMCC3317_RS07730 ENOG4105D5P Methylmalonyl-coA mutase IMCC3317_RS07765 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) IMCC3317_RS07770 ENOG4105SKN orotidine 5''-phosphate decarboxylase IMCC3317_RS07775 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) IMCC3317_RS07810 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) IMCC3317_RS07835 ENOG4108Y4K DNA-binding transcriptional activator IMCC3317_RS07855 ENOG4105CXB phosphoribosylaminoimidazole synthetase IMCC3317_RS07875 ENOG4107R5B glutamine synthetase IMCC3317_RS07910 ENOG4105CUG Oligopeptidase b IMCC3317_RS07925 ENOG4108JJA ABC, transporter IMCC3317_RS07955 ENOG4107TPS domain protein IMCC3317_RS07970 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) IMCC3317_RS07975 ENOG4105CP7 Triose-phosphate isomerase IMCC3317_RS08000 ENOG4105EEI dihydropteroate synthase IMCC3317_RS08020 ENOG4105C8B TIGR00159 family IMCC3317_RS08030 ENOG4105BZ1 (ABC) transporter IMCC3317_RS08035 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) IMCC3317_RS08090 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) IMCC3317_RS08095 ENOG4105RA3 Binds directly to 16S ribosomal RNA (By similarity) IMCC3317_RS08110 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) IMCC3317_RS08150 ENOG4105EUJ GTP cyclohydrolase i IMCC3317_RS08155 ENOG4105C8N cysteinyl-tRNA synthetase IMCC3317_RS08170 ENOG4107QZC Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) IMCC3317_RS08190 ENOG4106WTF Glycosyl transferase, family 2 IMCC3317_RS08210 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) IMCC3317_RS08245 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) IMCC3317_RS08265 ENOG4105DTQ mandelate racemase muconate lactonizing IMCC3317_RS08270 ENOG4105CAQ asparagine synthetase IMCC3317_RS08285 ENOG4105EFZ amidohydrolase IMCC3317_RS08310 ENOG4105CAK Cell division ATP-binding protein ftsE IMCC3317_RS08320 ENOG4107S6X Glycosyl transferase, family 2 IMCC3317_RS08330 ENOG4105CG5 Glycosyl transferase (Group 1 IMCC3317_RS08400 ENOG4106CC8 Bacterial inner membrane protein IMCC3317_RS08405 ENOG4105CI3 gtp-binding protein typa IMCC3317_RS08420 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) IMCC3317_RS08430 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase IMCC3317_RS08465 ENOG4105BZU Histidine kinase IMCC3317_RS08475 ENOG4108UB7 IMCC3317_RS08490 ENOG4105CT7 inner membrane cred family protein IMCC3317_RS08545 ENOG4105E5H Transposase IMCC3317_RS08585 ENOG4105E7D Protein of unknown function (DUF3375) IMCC3317_RS08605 ENOG4105D0M Protease HtpX homolog IMCC3317_RS08640 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) IMCC3317_RS08700 ENOG4105D06 uba thif-type nad fad binding protein IMCC3317_RS08740 ENOG4105WH1 Two component transcriptional regulator luxr family IMCC3317_RS08745 ENOG4105ENE Histidine kinase IMCC3317_RS08795 ENOG4108QXE glycerophosphoryl diester phosphodiesterase IMCC3317_RS08825 ENOG4105D7A ATP-binding protein IMCC3317_RS08860 ENOG4105C2F Histidine kinase IMCC3317_RS08865 ENOG4105DY9 regulatoR IMCC3317_RS08930 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) IMCC3317_RS08955 ENOG4108S3W Anti-feci sigma factor, fecr IMCC3317_RS08970 ENOG4105C75 arginyL-tRNA synthetase IMCC3317_RS09020 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) IMCC3317_RS09030 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain IMCC3317_RS09040 ENOG4108ZT0 50S ribosomal protein l17 IMCC3317_RS09045 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) IMCC3317_RS09050 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) IMCC3317_RS09055 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) IMCC3317_RS09060 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits IMCC3317_RS09065 ENOG410864M 50S ribosomal protein L36 IMCC3317_RS09070 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) IMCC3317_RS09075 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) IMCC3317_RS09080 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) IMCC3317_RS09085 ENOG41084HK 50S ribosomal protein L30 IMCC3317_RS09090 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) IMCC3317_RS09100 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) IMCC3317_RS09105 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) IMCC3317_RS09110 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) IMCC3317_RS09115 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits IMCC3317_RS09120 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) IMCC3317_RS09125 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) IMCC3317_RS09130 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal IMCC3317_RS09135 ENOG4105WNB 50s ribosomal protein l29 IMCC3317_RS09140 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) IMCC3317_RS09145 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) IMCC3317_RS09150 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) IMCC3317_RS09155 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) IMCC3317_RS09160 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity IMCC3317_RS09165 ENOG41081DX One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) IMCC3317_RS09170 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) IMCC3317_RS09175 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) IMCC3317_RS09180 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) IMCC3317_RS09185 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) IMCC3317_RS09190 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) IMCC3317_RS09195 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) IMCC3317_RS09205 ENOG4105C27 TonB-dependent Receptor Plug IMCC3317_RS09225 ENOG4105C27 TonB-dependent Receptor Plug IMCC3317_RS09245 ENOG4105C2N RNA methyltransferase TrmH family group 3 IMCC3317_RS09260 ENOG4105D1H recombination factor protein RarA IMCC3317_RS09290 ENOG4105W5Q DNA repair protein (RadC IMCC3317_RS09315 ENOG4105E5H Transposase IMCC3317_RS09365 ENOG4105C59 p-type ATPase IMCC3317_RS09385 ENOG410624X efflux transporter, rnd family, mfp subunit IMCC3317_RS09420 ENOG4105E3B Multicopper oxidase IMCC3317_RS09435 ENOG4108IJF Heavy metal efflux pump, CzcA IMCC3317_RS09485 ENOG4105CEP NADH dehydrogenase IMCC3317_RS09490 ENOG4105CUB amino acid IMCC3317_RS09500 ENOG4105EIE fructose-bisphosphate aldolase IMCC3317_RS09510 ENOG4105CTQ phosphohexokinase IMCC3317_RS09515 ENOG4107PU6 Membrane IMCC3317_RS09520 ENOG4105C5I Dehydrogenase IMCC3317_RS09540 ENOG4105CY0 Metallo-Beta-Lactamase IMCC3317_RS09545 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) IMCC3317_RS09550 ENOG4105C5T Phosphoribosyl pyrophosphate synthase IMCC3317_RS09570 ENOG4105DZQ phospholipase D Transphosphatidylase IMCC3317_RS09590 ENOG4105DFU Cell wall formation (By similarity) IMCC3317_RS09600 ENOG4107E2E PKHD-type hydroxylase IMCC3317_RS09640 ENOG4107S85 alpha-2-macroglobulin domain protein IMCC3317_RS09655 ENOG4108NEV two component transcriptional regulator, LytTR family IMCC3317_RS09660 ENOG4108HRK Histidine kinase IMCC3317_RS09665 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) IMCC3317_RS09670 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) IMCC3317_RS09675 ENOG4105DJY efflux transporter, rnd family, mfp subunit IMCC3317_RS09680 ENOG4105DFG type I secretion outer membrane protein IMCC3317_RS09710 ENOG4105C27 TonB-dependent Receptor Plug IMCC3317_RS09725 ENOG4105C27 TonB-dependent Receptor Plug IMCC3317_RS09730 ENOG4105EC3 peptidase S51, dipeptidase E IMCC3317_RS09740 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control IMCC3317_RS09745 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) IMCC3317_RS09750 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit IMCC3317_RS09755 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) IMCC3317_RS09760 ENOG4105DGW oligopeptidase A IMCC3317_RS09765 ENOG4105TRT Transcriptional regulator IMCC3317_RS09775 ENOG4105ECP epimerase IMCC3317_RS09810 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor IMCC3317_RS09815 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) IMCC3317_RS09825 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) IMCC3317_RS09875 ENOG4105DHJ ABC, transporter IMCC3317_RS09890 ENOG4108NEV two component transcriptional regulator, LytTR family IMCC3317_RS09895 ENOG4107R8N Glycosyl transferase, family 2 IMCC3317_RS09930 ENOG4105C7S Dehydrogenase IMCC3317_RS09935 ENOG4107R0V Pyruvate dehydrogenase IMCC3317_RS09940 ENOG4105KG3 cytidine deaminase IMCC3317_RS09955 ENOG4105E6M Sulphatase-modifying factor protein IMCC3317_RS09960 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) IMCC3317_RS09975 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase IMCC3317_RS10000 ENOG4105DN9 Na H antiporter IMCC3317_RS10010 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) IMCC3317_RS10015 ENOG4105C1G acyl-Coa dehydrogenase IMCC3317_RS10040 ENOG4108U3J IMCC3317_RS10060 ENOG4105BZU Histidine kinase IMCC3317_RS10070 ENOG4105DZP Membrane-associated zinc metalloprotease IMCC3317_RS10095 ENOG4105C3F Signal peptidase i IMCC3317_RS10115 ENOG4105C2F Histidine kinase IMCC3317_RS10120 ENOG4105DY9 regulatoR IMCC3317_RS10185 ENOG4105E5H Transposase IMCC3317_RS10235 ENOG4105BZ1 (ABC) transporter IMCC3317_RS10325 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) IMCC3317_RS10360 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) IMCC3317_RS10380 ENOG4105CRK lysyL-tRNA synthetase IMCC3317_RS10395 ENOG4108Z12 YiaAB two helix domain-containing protein IMCC3317_RS10415 ENOG410600T transposase IMCC3317_RS10430 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase IMCC3317_RS10435 ENOG4105K4H Nlp p60 protein IMCC3317_RS10440 ENOG4105K6H D-cysteine desulfhydrase IMCC3317_RS10450 ENOG4105C27 TonB-dependent Receptor Plug IMCC3317_RS10500 ENOG4105CGP Urocanate hydratase IMCC3317_RS10515 ENOG4105CPF Cell wall formation (By similarity) IMCC3317_RS10540 ENOG4105CPP Dehydrogenase, E1 component IMCC3317_RS10545 ENOG4105CM2 brancheD-chain amino acid aminotransferase IMCC3317_RS10550 ENOG4105C7S Dehydrogenase IMCC3317_RS10555 ENOG4105J0Q Transcriptional regulator IMCC3317_RS10585 ENOG4105DXM phenylacetic acid degradation protein IMCC3317_RS10590 ENOG4105CHU acetyl-coa acetyltransferase IMCC3317_RS10605 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase IMCC3317_RS10615 ENOG4108UKI Enoyl-CoA hydratase IMCC3317_RS10620 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit IMCC3317_RS10625 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit IMCC3317_RS10630 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit IMCC3317_RS10635 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit IMCC3317_RS10640 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) IMCC3317_RS10650 ENOG4105MIR Phenylalanine 4-monooxygenase IMCC3317_RS10670 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) IMCC3317_RS10675 ENOG4108K5P (LipO)protein IMCC3317_RS10685 ENOG4108V0P LemA family IMCC3317_RS10695 ENOG4105HA9 of methanol dehydrogenase type IMCC3317_RS10715 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) IMCC3317_RS10725 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) IMCC3317_RS10765 ENOG4108VCT Sulfite exporter TauE/SafE IMCC3317_RS10770 ENOG4107TPS domain protein IMCC3317_RS10795 ENOG4105BZU Histidine kinase IMCC3317_RS10870 ENOG4105C27 TonB-dependent Receptor Plug IMCC3317_RS10885 ENOG4105D7N magnesium and cobalt transport protein CorA IMCC3317_RS10895 ENOG4105D64 Mechanosensitive ion channel IMCC3317_RS10915 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) IMCC3317_RS10985 ENOG4105CHR reductase IMCC3317_RS11005 ENOG4107YD3 Thioesterase IMCC3317_RS11010 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) IMCC3317_RS11050 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) IMCC3317_RS11060 ENOG41087PP glycosyltransferase MGT family IMCC3317_RS11070 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) IMCC3317_RS11095 ENOG4105CHR reductase IMCC3317_RS11100 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) IMCC3317_RS11150 ENOG4105DA5 (ABC) transporter IMCC3317_RS11205 ENOG4108URH decarboxylase IMCC3317_RS11210 ENOG4107QWP ABC-2 type transporter IMCC3317_RS11215 ENOG4107QWP ABC-2 type transporter IMCC3317_RS11225 ENOG4105CJ1 ABC, transporter IMCC3317_RS11230 ENOG4105CJ1 ABC, transporter IMCC3317_RS11245 ENOG4105D0S secretion protein (HlyD IMCC3317_RS11280 ENOG4108JJA ABC, transporter IMCC3317_RS11300 ENOG4105C5H ABC transporter IMCC3317_RS11330 ENOG4105E6M Sulphatase-modifying factor protein IMCC3317_RS11370 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) IMCC3317_RS11385 ENOG4107WT5 transcriptional regulator (NifA IMCC3317_RS11405 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) IMCC3317_RS11410 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) IMCC3317_RS11440 ENOG410600T transposase IMCC3317_RS11470 ENOG4105E5H Transposase IMCC3317_RS11495 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin IMCC3317_RS11525 ENOG4105DC1 bifunctional purine biosynthesis protein purh IMCC3317_RS11530 ENOG4105DFF Rod shape-determining protein mreb IMCC3317_RS11545 ENOG4105CJN penicillin-binding protein IMCC3317_RS11550 ENOG4105CNI cell division protein FtsW IMCC3317_RS11570 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component IMCC3317_RS11575 ENOG4105CN1 protease IMCC3317_RS11580 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) IMCC3317_RS11590 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) IMCC3317_RS11595 ENOG4107TT5 NLP P60 protein IMCC3317_RS11600 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 IMCC3317_RS11610 ENOG4105DUX Transporter IMCC3317_RS11615 ENOG4105DUX Transporter IMCC3317_RS11620 ENOG4105C5Z peptidase IMCC3317_RS11635 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) IMCC3317_RS11640 ENOG4105C37 (CBS) domain IMCC3317_RS11665 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) IMCC3317_RS11675 ENOG4108NEV two component transcriptional regulator, LytTR family IMCC3317_RS11680 ENOG4108HRK Histidine kinase IMCC3317_RS11760 ENOG4105C72 UPF0176 protein IMCC3317_RS11770 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) IMCC3317_RS11775 ENOG4105DVA methyltransferase IMCC3317_RS11815 ENOG4105KME endoribonuclease L-psp IMCC3317_RS11835 ENOG4107QZF nitrite reductase NADPH large subunit IMCC3317_RS11850 ENOG4105CND Glycosyl transferase, family 2 IMCC3317_RS11895 ENOG4105FE9 pseudouridine synthase IMCC3317_RS11920 ENOG4105CBX hi0933 family IMCC3317_RS11935 ENOG4105FE9 pseudouridine synthase IMCC3317_RS11945 ENOG4105DY9 regulatoR IMCC3317_RS11950 ENOG4108HRK Histidine kinase IMCC3317_RS11965 ENOG4105WKZ CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) IMCC3317_RS11975 ENOG4105E9M CRISPR-associated protein, Csn1 family IMCC3317_RS12065 ENOG4105DR5 peptidase IMCC3317_RS12130 ENOG4108ZIT Ferredoxin, 2FE-2S IMCC3317_RS12135 ENOG4105CAY ferredoxin--nadp reductase IMCC3317_RS12165 ENOG4107UGT Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) IMCC3317_RS12170 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) IMCC3317_RS12175 ENOG4105BZU Histidine kinase IMCC3317_RS12180 ENOG4105CK6 Two component transcriptional regulator (Winged helix family IMCC3317_RS12200 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) IMCC3317_RS12220 ENOG4105CD3 dihydroorotase IMCC3317_RS12225 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) IMCC3317_RS12240 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase IMCC3317_RS12245 ENOG4105M08 Membrane IMCC3317_RS12255 ENOG4108VVK transcriptional Regulator, AsnC IMCC3317_RS12260 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) IMCC3317_RS12275 ENOG4105C8T Leucyl-tRNA synthetase IMCC3317_RS12280 ENOG4107RJ9 Cell division protein FtsX IMCC3317_RS12305 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) IMCC3317_RS12310 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) IMCC3317_RS12320 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) IMCC3317_RS12325 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) IMCC3317_RS12340 ENOG4107XWI flavin reductase domain protein, FMN-binding IMCC3317_RS12345 ENOG4105BZU Histidine kinase IMCC3317_RS12355 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) IMCC3317_RS12365 ENOG4105C27 TonB-dependent Receptor Plug IMCC3317_RS12385 ENOG4105DQ6 Transposase IMCC3317_RS12395 ENOG4108RCS geranylgeranylglyceryl phosphate synthase IMCC3317_RS12405 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) IMCC3317_RS12410 ENOG4105EQD regulatoR IMCC3317_RS12455 ENOG4105DGW oligopeptidase A IMCC3317_RS12460 ENOG4105K46 50S ribosomal protein l27 IMCC3317_RS12465 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) IMCC3317_RS12490 ENOG4105C59 p-type ATPase IMCC3317_RS12500 ENOG4105C9B Cysteine desulfurase IMCC3317_RS12515 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) IMCC3317_RS12520 ENOG4105VG1 fes assembly suf system protein IMCC3317_RS12575 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) IMCC3317_RS12595 ENOG4105UYK outer membrane protein a IMCC3317_RS12610 ENOG4105D06 uba thif-type nad fad binding protein IMCC3317_RS12800 ENOG4105DY9 regulatoR IMCC3317_RS12835 ENOG4105DZP Membrane-associated zinc metalloprotease IMCC3317_RS12845 ENOG4108KF3 Electron transport protein SCO1 SenC IMCC3317_RS12855 ENOG4105CE1 Ferrous iron transport protein b IMCC3317_RS12875 ENOG4107RBD ABC, transporter IMCC3317_RS12880 ENOG4107RPQ ABC transporter IMCC3317_RS12895 ENOG4105DIK (ABC) transporter IMCC3317_RS12900 ENOG4105DSE periplasmic solute binding protein IMCC3317_RS12935 ENOG4105BZS acriflavin resistance protein IMCC3317_RS12965 ENOG4105C27 TonB-dependent Receptor Plug IMCC3317_RS12970 ENOG4105C9M aspartyl-trna synthetase IMCC3317_RS12995 ENOG4108Z6B deaminase IMCC3317_RS13000 ENOG4105DY9 regulatoR IMCC3317_RS13030 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) IMCC3317_RS13070 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) IMCC3317_RS13085 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein IMCC3317_RS13100 ENOG4105CN1 protease IMCC3317_RS13115 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) IMCC3317_RS13120 ENOG4108Y6J UPF0403 protein IMCC3317_RS13170 ENOG4105E39 Enoyl-CoA hydratase IMCC3317_RS13195 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) IMCC3317_RS13210 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) IMCC3317_RS13220 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) IMCC3317_RS13275 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) IMCC3317_RS13285 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) IMCC3317_RS13305 ENOG4105D52 delta-aminolevulinic acid dehydratase IMCC3317_RS13325 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) IMCC3317_RS13365 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin IMCC3317_RS13460 ENOG4108IIH CoA-transferase subunit B IMCC3317_RS13465 ENOG4107QP7 CoA-transferase subunit A IMCC3317_RS13470 ENOG4108JQC penicillin-binding protein 1A IMCC3317_RS13475 ENOG410647Z gliding motility-associated lipoprotein GldH IMCC3317_RS13480 ENOG4105MA4 psp1 domain protein IMCC3317_RS13495 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) IMCC3317_RS13520 ENOG4105C31 Tryptophanyl-tRNA synthetase IMCC3317_RS13545 ENOG4108S4H thioesterase Superfamily protein IMCC3317_RS13560 ENOG4108HRK Histidine kinase IMCC3317_RS13565 ENOG4106WF9 DNA-binding transcriptional regulator TorR IMCC3317_RS13585 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) IMCC3317_RS13590 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) IMCC3317_RS13625 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) IMCC3317_RS13635 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) IMCC3317_RS13640 ENOG4107Z4P F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) IMCC3317_RS13645 ENOG4107Z65 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) IMCC3317_RS13650 ENOG4105VHG atp synthase IMCC3317_RS13655 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) IMCC3317_RS13675 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) IMCC3317_RS13685 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) IMCC3317_RS13690 ENOG4105DKP glycosyl transferase, family 9 IMCC3317_RS13720 ENOG4105C12 Phosphoribosylglycinamide synthetase IMCC3317_RS13735 ENOG4108IAJ Nad-dependent epimerase dehydratase IMCC3317_RS13740 ENOG4105C6Y Udp-glucose 6-dehydrogenase IMCC3317_RS13750 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase IMCC3317_RS13760 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family IMCC3317_RS13775 ENOG4105D3Q Sugar transferase IMCC3317_RS13790 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) IMCC3317_RS13815 ENOG4105CAQ asparagine synthetase IMCC3317_RS13855 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein IMCC3317_RS13865 ENOG4108IJ1 Dehydrogenase IMCC3317_RS13870 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase IMCC3317_RS13875 ENOG4107QQG Dehydrogenase IMCC3317_RS13885 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase IMCC3317_RS13890 ENOG4107R3N Filamentation induced by cAMP protein fic IMCC3317_RS13905 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase IMCC3317_RS13915 ENOG4105C1B dTDP-glucose 4-6-dehydratase IMCC3317_RS13935 ENOG41063SB peptidase IMCC3317_RS13940 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) IMCC3317_RS13965 ENOG4105BZM domain protein IMCC3317_RS13980 ENOG4105BZA Phosphoglycerate kinase IMCC3317_RS13985 ENOG4107QRG dna polymerase iii IMCC3317_RS14050 ENOG4108VAC response regulator IMCC3317_RS14060 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) IMCC3317_RS14070 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) IMCC3317_RS14080 ENOG4107QUV Domain protein IMCC3317_RS14105 ENOG4105C8F Beta-lactamase domain protein IMCC3317_RS14150 ENOG4105WG6 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) IMCC3317_RS14155 ENOG4105CN1 protease IMCC3317_RS14160 ENOG4107YB6 acetyltransferase, (GNAT) family IMCC3317_RS14165 ENOG4108YZG isomerase IMCC3317_RS14175 ENOG4107TE5 Lipid kinase IMCC3317_RS14180 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) IMCC3317_RS14185 ENOG4105K8R UPF0145 protein IMCC3317_RS14220 ENOG4105CX6 glutaminyL-tRNA synthetase IMCC3317_RS14230 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin IMCC3317_RS14255 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) IMCC3317_RS14265 ENOG4105EEF Alkane 1-monooxygenase IMCC3317_RS14275 ENOG41080AX Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) IMCC3317_RS14280 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) IMCC3317_RS14285 ENOG4105HHS UPF0256 protein IMCC3317_RS14290 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) IMCC3317_RS14315 ENOG4108YYC ycei family IMCC3317_RS14330 ENOG4105CB5 ATP-dependent DNA helicase recG IMCC3317_RS14345 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase IMCC3317_RS14350 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein IMCC3317_RS14355 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) IMCC3317_RS14360 ENOG4105WXV 50S ribosomal protein L32 IMCC3317_RS14370 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) IMCC3317_RS14375 ENOG4108R6K riboflavin synthase, subunit alpha IMCC3317_RS14420 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) IMCC3317_RS14435 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) IMCC3317_RS14440 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) IMCC3317_RS14445 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) IMCC3317_RS14450 ENOG4107T8J thymidine kinase IMCC3317_RS14490 ENOG4105VC4 domain protein IMCC3317_RS14495 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) IMCC3317_RS14505 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) IMCC3317_RS14510 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase IMCC3317_RS14525 ENOG4107R73 Mate efflux family protein IMCC3317_RS14570 ENOG4105C4R Atp-dependent dna helicase IMCC3317_RS14575 ENOG4105CDV Ompa motb domain protein IMCC3317_RS14580 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) IMCC3317_RS14585 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation IMCC3317_RS14600 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) IMCC3317_RS14605 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase IMCC3317_RS14620 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) IMCC3317_RS14625 ENOG4108V3E phosphoribosylglycinamide formyltransferase IMCC3317_RS14630 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) IMCC3317_RS14635 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) IMCC3317_RS14640 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) IMCC3317_RS14650 ENOG4105CA9 Pyruvate kinase IMCC3317_RS14665 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) IMCC3317_RS14675 ENOG4105H4N Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) IMCC3317_RS14695 ENOG41080ZE Adenylate cyclase IMCC3317_RS14710 ENOG4105E0Y RtcB Protein IMCC3317_RS14720 ENOG4108S2Y peptide Chain Release factor IMCC3317_RS14735 ENOG4105DZP Membrane-associated zinc metalloprotease IMCC3317_RS14755 ENOG4108JQB penicillin-binding protein 1C IMCC3317_RS14760 ENOG4105KAC Antibiotic biosynthesis monooxygenase IMCC3317_RS14770 ENOG4105DN3 alpha-2-macroglobulin domain protein IMCC3317_RS14775 ENOG4105D44 asparaginase IMCC3317_RS14795 ENOG4105C3W Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate (By similarity) IMCC3317_RS14805 ENOG4105C26 Dehydrogenase IMCC3317_RS14815 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) IMCC3317_RS14835 ENOG4105EMU Dehydrogenase IMCC3317_RS14840 ENOG4107QM2 Aldo Keto reductase IMCC3317_RS14845 ENOG4107RJ1 sodium solute IMCC3317_RS14850 ENOG4105C7R Atpase associated with various cellular activities aaa_3 IMCC3317_RS14895 ENOG4105CHH sulfate transporter IMCC3317_RS14920 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) IMCC3317_RS14930 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase IMCC3317_RS14940 ENOG4109066 lysm domain bon superfamily protein IMCC3317_RS14950 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) IMCC3317_RS14955 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) IMCC3317_RS14960 ENOG4105DSJ YicC domain protein IMCC3317_RS14995 ENOG4108M24 von Willebrand factor, type A IMCC3317_RS15010 ENOG4108M24 von Willebrand factor, type A IMCC3317_RS15015 ENOG4106FN3 tellurium resistance protein IMCC3317_RS15030 ENOG4106FN3 tellurium resistance protein IMCC3317_RS15050 ENOG4108YZA Nitrogen regulatory protein pii IMCC3317_RS15065 ENOG4105BZ8 glutamate synthase IMCC3317_RS15075 ENOG4105C01 Dihydroxy-acid dehydratase IMCC3317_RS15080 ENOG4105C7K acetolactate synthase IMCC3317_RS15085 ENOG4108ZP8 Acetolactate synthase small subunit IMCC3317_RS15090 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase IMCC3317_RS15095 ENOG4105C7B Threonine dehydratase IMCC3317_RS15100 ENOG4105C26 Dehydrogenase IMCC3317_RS15125 ENOG4105EEQ Na H antiporter IMCC3317_RS15140 ENOG4105C28 cystathionine IMCC3317_RS15150 ENOG4107R37 Glutamate dehydrogenase IMCC3317_RS15160 ENOG41060VI Involved in DNA repair and RecF pathway recombination (By similarity) IMCC3317_RS15165 ENOG4105D05 Receptor IMCC3317_RS15175 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) IMCC3317_RS15195 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase IMCC3317_RS15205 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) IMCC3317_RS15215 ENOG4105F1J Homogentisate 1,2-dioxygenase IMCC3317_RS15220 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase IMCC3317_RS15230 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) IMCC3317_RS15260 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) IMCC3317_RS15270 ENOG4107QP8 phosphohexose isomerase IMCC3317_RS15275 ENOG4105C27 TonB-dependent Receptor Plug IMCC3317_RS15305 ENOG4105CUG Oligopeptidase b IMCC3317_RS15370 ENOG4105CJQ hydrolase, family 31 IMCC3317_RS15375 ENOG4108SA1 esterase IMCC3317_RS15380 ENOG4108IUK alpha amylase, catalytic IMCC3317_RS15390 ENOG4107URF beta-phospho-glucomutase IMCC3317_RS15400 ENOG4105ETE Transcriptional regulator (LacI family IMCC3317_RS15405 ENOG4105C27 TonB-dependent Receptor Plug IMCC3317_RS15420 ENOG4108IUK alpha amylase, catalytic IMCC3317_RS15435 ENOG4105DJ4 phosphatidylserine decarboxylase IMCC3317_RS15450 ENOG4107RRE RNA-directed DNA polymerase IMCC3317_RS15460 ENOG4108JJA ABC, transporter IMCC3317_RS15520 ENOG4105EXW epimerase dehydratase IMCC3317_RS15535 ENOG4105C9K Endothelin-converting enzyme 1 IMCC3317_RS15545 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) IMCC3317_RS15560 ENOG41068WN IMCC3317_RS15565 ENOG4107XMK single-stranded DNA-binding protein IMCC3317_RS15575 ENOG4105C59 p-type ATPase IMCC3317_RS15585 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i IMCC3317_RS15595 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) IMCC3317_RS15600 ENOG4105C58 cytochrome c oxidase accessory protein ccog IMCC3317_RS15615 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) IMCC3317_RS15630 ENOG4107YZX Universal stress protein IMCC3317_RS15640 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) IMCC3317_RS15650 ENOG4105F5P DNA-damage-inducible protein d IMCC3317_RS15680 ENOG4108UT2 hemolysin iii IMCC3317_RS15690 ENOG4108JQ1 Dehydrogenase IMCC3317_RS15700 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) IMCC3317_RS15705 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) IMCC3317_RS15710 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) IMCC3317_RS15715 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) IMCC3317_RS15730 ENOG41090A1 ferritin IMCC3317_RS15735 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) IMCC3317_RS15740 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A IMCC3317_RS15750 ENOG41080R2 UPF0102 protein IMCC3317_RS15800 ENOG4108JA2 transcriptioN-repair coupling factor IMCC3317_RS15815 ENOG4105BZU Histidine kinase IMCC3317_RS15835 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 IMCC3317_RS15845 ENOG4105CFH Aspartokinase IMCC3317_RS15855 ENOG4105CGK Exodeoxyribonuclease III IMCC3317_RS15860 ENOG4105CPC Aldo Keto reductase IMCC3317_RS15865 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) IMCC3317_RS15880 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) IMCC3317_RS15885 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) IMCC3317_RS15890 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) IMCC3317_RS15900 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) IMCC3317_RS15905 ENOG4105C27 TonB-dependent Receptor Plug IMCC3317_RS15910 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) IMCC3317_RS15915 ENOG41082MC Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) IMCC3317_RS15930 ENOG4108UB4 uncharacterized protein ygjQ IMCC3317_RS15950 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) IMCC3317_RS15970 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) IMCC3317_RS16025 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) IMCC3317_RS16035 ENOG41087A8 Modulates RecA activity (By similarity) IMCC3317_RS16065 ENOG4105C03 ribonuclease IMCC3317_RS16070 ENOG4105K70 DNA-binding protein IMCC3317_RS16080 ENOG4108UUM single-stranded DNA-binding protein IMCC3317_RS16085 ENOG4105C37 (CBS) domain IMCC3317_RS16145 ENOG4108Z4V iron-sulfur cluster assembly IMCC3317_RS16160 ENOG4105CA0 peroxidase IMCC3317_RS16170 ENOG4105WH1 Two component transcriptional regulator luxr family IMCC3317_RS16185 ENOG4107S1E Beta-lactamase IMCC3317_RS16255 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) IMCC3317_RS16285 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) IMCC3317_RS16320 ENOG4105E33 succinate dehydrogenase IMCC3317_RS16325 ENOG4105IIU Aminopeptidase IMCC3317_RS16355 ENOG4105CHM Aminotransferase IMCC3317_RS16380 ENOG4108HRK Histidine kinase IMCC3317_RS16385 ENOG4105DY9 regulatoR IMCC3317_RS16390 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase IMCC3317_RS16405 ENOG4105MJ2 Competence protein IMCC3317_RS16420 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) IMCC3317_RS16445 ENOG4108UXE Protein tyrosine phosphatase IMCC3317_RS16480 ENOG4105C5I Dehydrogenase IMCC3317_RS16495 ENOG4105CJW magnesium transporter IMCC3317_RS16500 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) IMCC3317_RS16525 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) IMCC3317_RS16535 ENOG4105DTN riboflavin biosynthesis protein ribF IMCC3317_RS16540 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) IMCC3317_RS16545 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) IMCC3317_RS16550 ENOG4105C5T Phosphoribosyl pyrophosphate synthase IMCC3317_RS16575 ENOG4105E5H Transposase IMCC3317_RS16595 ENOG4105WH1 Two component transcriptional regulator luxr family IMCC3317_RS16730 ENOG4105W5Q DNA repair protein (RadC IMCC3317_RS16800 ENOG4105EXU Membrane IMCC3317_RS16815 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 IMCC3317_RS16820 ENOG4105C7S Dehydrogenase IMCC3317_RS16835 ENOG4105F8V Hydrolase, tatD family IMCC3317_RS16840 ENOG4105HDK L-asparaginase IMCC3317_RS16880 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) IMCC3317_RS16885 ENOG4105C5S asparaginyl-tRNA synthetase IMCC3317_RS16900 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) IMCC3317_RS16905 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) IMCC3317_RS16915 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) IMCC3317_RS16920 ENOG4105CE9 30S ribosomal protein S2 IMCC3317_RS16925 ENOG4108UJD 30S ribosomal protein S9 IMCC3317_RS16930 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) IMCC3317_RS16940 ENOG4105EE5 Membrane protein terC IMCC3317_RS16955 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) IMCC3317_RS16970 ENOG4105C4X radical SAM domain protein IMCC3317_RS16990 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) IMCC3317_RS17040 ENOG4105C3Q Glycosyl transferase, family 2 IMCC3317_RS17055 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) IMCC3317_RS17060 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) IMCC3317_RS17065 ENOG410819C Methyltransferase IMCC3317_RS17090 ENOG4105WH1 Two component transcriptional regulator luxr family IMCC3317_RS17095 ENOG4105BZU Histidine kinase IMCC3317_RS17110 ENOG4105C2M dna polymerase I IMCC3317_RS17120 ENOG4105D44 asparaginase IMCC3317_RS17125 ENOG4105DDG Cyanophycinase IMCC3317_RS17140 ENOG4105K63 Thioredoxin IMCC3317_RS17145 ENOG4108ZJ4 polysaccharide deacetylase IMCC3317_RS17160 ENOG4108JJA ABC, transporter IMCC3317_RS17195 ENOG4107YZX Universal stress protein IMCC3317_RS17200 ENOG41090IP Required for maturation of 30S ribosomal subunits (By similarity) IMCC3317_RS17205 ENOG4105CHV Transcription elongation factor NusA IMCC3317_RS17210 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) IMCC3317_RS17225 ENOG4107SFQ iron-sulfur binding IMCC3317_RS17255 ENOG4105BZ9 Cytochrome C oxidase, subunit I IMCC3317_RS17260 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) IMCC3317_RS17270 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) IMCC3317_RS17275 ENOG4105C6K Malic enzyme IMCC3317_RS17280 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) IMCC3317_RS17290 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) IMCC3317_RS17315 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) IMCC3317_RS17320 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) IMCC3317_RS17325 ENOG4105CCU oxidase (Subunit III) IMCC3317_RS17350 ENOG4108SJC Membrane IMCC3317_RS17360 ENOG4105C19 ABC transporter IMCC3317_RS17365 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) IMCC3317_RS17370 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) IMCC3317_RS17385 ENOG41072GX Peptidase M22 Glycoprotease IMCC3317_RS17425 ENOG4108HRK Histidine kinase IMCC3317_RS17430 ENOG4108MRH transcriptional regulatory protein IMCC3317_RS17435 ENOG4108Z0R Transferase IMCC3317_RS17445 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) IMCC3317_RS17465 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane IMCC3317_RS17470 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) IMCC3317_RS17480 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) IMCC3317_RS17490 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) IMCC3317_RS17495 ENOG4105EV9 Alpha Beta Hydrolase IMCC3317_RS17510 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation IMCC3317_RS17520 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) IMCC3317_RS17545 ENOG4105UYK outer membrane protein a IMCC3317_RS17585 ENOG4105C2N RNA methyltransferase TrmH family group 3 IMCC3317_RS17590 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) IMCC3317_RS17635 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) IMCC3317_RS17640 ENOG4107YAY An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) IMCC3317_RS17645 ENOG4105K5M 30s ribosomal protein S16 IMCC3317_RS17650 ENOG4105C0B DNA polymerase III (alpha subunit) IMCC3317_RS17655 ENOG4105C27 TonB-dependent Receptor Plug IMCC3317_RS17730 ENOG4105CMM transposase IMCC3317_RS17750 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) IMCC3317_RS17760 ENOG4105CSA Coproporphyrinogen iii oxidase IMCC3317_RS17795 ENOG4105XDF Protein of unknown function (DUF1272) IMCC3317_RS17815 ENOG4105DY9 regulatoR IMCC3317_RS17865 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase IMCC3317_RS17870 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase IMCC3317_RS17875 ENOG4105CMR udp-glucose 4-epimerase IMCC3317_RS17880 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) IMCC3317_RS17895 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) IMCC3317_RS17900 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase IMCC3317_RS17910 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) IMCC3317_RS17930 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) IMCC3317_RS17945 ENOG4105D9N nucleoside IMCC3317_RS17955 ENOG4105C10 Electron transfer flavoprotein IMCC3317_RS17960 ENOG4105BZJ Electron transfer flavoprotein IMCC3317_RS17965 ENOG4105CPP Dehydrogenase, E1 component IMCC3317_RS17975 ENOG4105F0N pyrophosphate phospho-hydrolase IMCC3317_RS17980 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for IMCC3317_RS18000 ENOG4105ZMH deoxynucleoside kinase IMCC3317_RS18075 ENOG4105WH1 Two component transcriptional regulator luxr family IMCC3317_RS18100 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP IMCC3317_RS18110 ENOG4105DWV Homoserine O-trans-acetylase IMCC3317_RS18115 ENOG4105CFH Aspartokinase IMCC3317_RS18120 ENOG4105C28 cystathionine IMCC3317_RS18135 ENOG4105C11 sulfate adenylyltransferase), subunit 2 IMCC3317_RS18140 ENOG4107QK2 May be the GTPase, regulating ATP sulfurylase activity (By similarity) IMCC3317_RS18145 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) IMCC3317_RS18150 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) IMCC3317_RS18155 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) IMCC3317_RS18160 ENOG4105CAY ferredoxin--nadp reductase IMCC3317_RS18175 ENOG4105C3R Methionine synthase IMCC3317_RS18180 ENOG4105C3R Methionine synthase IMCC3317_RS18230 ENOG4105CHM Aminotransferase IMCC3317_RS18240 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase IMCC3317_RS18275 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) IMCC3317_RS18280 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) IMCC3317_RS18305 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) IMCC3317_RS18320 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs IMCC3317_RS18345 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) IMCC3317_RS18355 ENOG4105WH1 Two component transcriptional regulator luxr family IMCC3317_RS18360 ENOG4107RA1 nh(3)-dependent nad( ) synthetase IMCC3317_RS18385 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) IMCC3317_RS18395 ENOG4107YM1 mraZ protein IMCC3317_RS18400 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) IMCC3317_RS18410 ENOG4105CJN penicillin-binding protein IMCC3317_RS18415 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) IMCC3317_RS18420 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) IMCC3317_RS18425 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) IMCC3317_RS18430 ENOG4105CNI cell division protein FtsW IMCC3317_RS18440 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) IMCC3317_RS18445 ENOG4105DFU Cell wall formation (By similarity) IMCC3317_RS18455 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) IMCC3317_RS18460 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) IMCC3317_RS18465 ENOG4105KTH gatB Yqey IMCC3317_RS18505 ENOG4108W1A pseudouridine synthase IMCC3317_RS18510 ENOG4105CCT upf0313 protein IMCC3317_RS18520 ENOG4105EY3 heparinase II III family protein IMCC3317_RS18530 ENOG4105C27 TonB-dependent Receptor Plug IMCC3317_RS18540 ENOG4107YCY Transcriptional regulator IMCC3317_RS18545 ENOG4105DPW Major facilitator superfamily MFS_1 IMCC3317_RS18550 ENOG4105H9W Short-chain dehydrogenase reductase Sdr IMCC3317_RS18555 ENOG4105ETE Transcriptional regulator (LacI family IMCC3317_RS18590 ENOG4108JPW Aminotransferase IMCC3317_RS18595 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) IMCC3317_RS18625 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein IMCC3317_RS18630 ENOG4105CH7 arginosuccinase IMCC3317_RS18635 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) IMCC3317_RS18640 ENOG4107T6X nag kinase IMCC3317_RS18645 ENOG4107REN Carbamoyltransferase IMCC3317_RS18650 ENOG4105C8Y Acetylornithine aminotransferase IMCC3317_RS18655 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase IMCC3317_RS18660 ENOG4105CDH Citrulline--aspartate ligase IMCC3317_RS18690 ENOG4107QN1 sodium solute IMCC3317_RS18700 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) IMCC3317_RS18720 ENOG4105R48 this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase IMCC3317_RS18730 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) IMCC3317_RS18740 ENOG4105C1J atp-dependent rna helicase IMCC3317_RS18770 ENOG4105CHP RNA polymerase IMCC3317_RS18790 ENOG4105CVP deoxyribo-dipyrimidine photolyase IMCC3317_RS18795 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein IMCC3317_RS18820 ENOG4108HRK Histidine kinase IMCC3317_RS18845 ENOG4105DJV ribulose-phosphate 3-epimerase IMCC3317_RS18850 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) IMCC3317_RS18875 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) IMCC3317_RS18880 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) IMCC3317_RS18890 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) IMCC3317_RS18895 ENOG4105D2N Aldolase IMCC3317_RS18915 ENOG4105C2N RNA methyltransferase TrmH family group 3 IMCC3317_RS18935 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) IMCC3317_RS18940 ENOG4105C1A potassium transporter peripheral membrane IMCC3317_RS18945 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) IMCC3317_RS18960 ENOG4105CHM Aminotransferase IMCC3317_RS18965 ENOG4105ECK Fatty Acid Desaturase IMCC3317_RS18970 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) IMCC3317_RS19000 ENOG4105C26 Dehydrogenase IMCC3317_RS19055 ENOG4105NWN ApaG protein IMCC3317_RS19065 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) IMCC3317_RS19070 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) IMCC3317_RS19075 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) IMCC3317_RS19080 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) IMCC3317_RS19085 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) IMCC3317_RS19105 ENOG4108HRK Histidine kinase IMCC3317_RS19110 ENOG4108NEV two component transcriptional regulator, LytTR family IMCC3317_RS19180 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) IMCC3317_RS19195 ENOG4108K0D peptidase, M48 IMCC3317_RS19225 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) IMCC3317_RS19245 ENOG4108CSZ Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) IMCC3317_RS19255 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin IMCC3317_RS19265 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) IMCC3317_RS19270 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) IMCC3317_RS19325 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) IMCC3317_RS19360 ENOG4105CHR reductase IMCC3317_RS19380 ENOG4105DUX Transporter IMCC3317_RS19395 ENOG4105EGD dinuclear metal center protein, YbgI family IMCC3317_RS19405 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) IMCC3317_RS19415 ENOG4105BZU Histidine kinase IMCC3317_RS19420 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase IMCC3317_RS19435 ENOG4105BZU Histidine kinase IMCC3317_RS19440 ENOG4105WH1 Two component transcriptional regulator luxr family IMCC3317_RS19450 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) IMCC3317_RS19455 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) IMCC3317_RS19465 ENOG4107S6X Glycosyl transferase, family 2 IMCC3317_RS19485 ENOG4105DQ6 Transposase IMCC3317_RS19490 ENOG4107R0I Cell wall formation (By similarity) IMCC3317_RS19495 ENOG4105CHM Aminotransferase IMCC3317_RS19510 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) IMCC3317_RS19515 ENOG4105KRP Plasmid stabilization system IMCC3317_RS19535 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme IMCC3317_RS19540 ENOG4105KNE Phosphatidate cytidylyltransferase IMCC3317_RS19550 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) IMCC3317_RS19555 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) IMCC3317_RS19560 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase IMCC3317_RS19570 ENOG4107RIV Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) IMCC3317_RS19575 ENOG41062IR nudix hydrolase IMCC3317_RS19585 ENOG4105CHH sulfate transporter IMCC3317_RS19595 ENOG4105BZU Histidine kinase IMCC3317_RS19600 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) IMCC3317_RS19605 ENOG4105CPF Cell wall formation (By similarity) IMCC3317_RS19615 ENOG4105C34 Pseudouridine synthase IMCC3317_RS19645 ENOG4105W5Q DNA repair protein (RadC IMCC3317_RS19840 ENOG4105DZR Type I site-specific deoxyribonuclease IMCC3317_RS19985 ENOG4105D1Q UPF0246 protein IMCC3317_RS20000 ENOG4105KAF membrAne IMCC3317_RS20015 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) IMCC3317_RS20025 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) IMCC3317_RS20035 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) IMCC3317_RS20045 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase IMCC3317_RS20050 ENOG4105DK0 Indole-3-glycerol phosphate synthase IMCC3317_RS20055 ENOG4108I0Q anthranilate phosphoribosyltransferase IMCC3317_RS20060 ENOG4105DDQ anthranilate synthase IMCC3317_RS20065 ENOG4105CRQ synthase (Component I) IMCC3317_RS20075 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes IMCC3317_RS20095 ENOG4107QX9 Thiol disulfide interChange protein IMCC3317_RS20105 ENOG41085GJ domain protein IMCC3317_RS20110 ENOG41082J7 Rhodanese domain protein IMCC3317_RS20135 ENOG4107SVH Potassium channel protein IMCC3317_RS20140 ENOG4105BZG amino acid carrier protein IMCC3317_RS20150 ENOG4105C1G acyl-Coa dehydrogenase IMCC3317_RS20160 ENOG41083X6 30S ribosomal protein S21 IMCC3317_RS20165 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) IMCC3317_RS20170 ENOG4105MS2 ribosomal subunit Interface protein IMCC3317_RS20195 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) IMCC3317_RS20215 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) IMCC3317_RS20220 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) IMCC3317_RS20225 ENOG4107VNI ribosomal protein l10 IMCC3317_RS20230 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) IMCC3317_RS20235 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) IMCC3317_RS20240 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) IMCC3317_RS20250 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) IMCC3317_RS20270 ENOG4105KCK Peptidoglycan-associated lipoprotein IMCC3317_RS20285 ENOG4105DG6 mannose-6-phosphate isomerase IMCC3317_RS20305 ENOG4105C1J atp-dependent rna helicase IMCC3317_RS20365 ENOG4108UQS dipeptidase IMCC3317_RS20395 ENOG4105C34 Pseudouridine synthase IMCC3317_RS20400 ENOG4105FQP Beta-lactamase IMCC3317_RS20405 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) IMCC3317_RS20410 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) IMCC3317_RS20425 ENOG4107RJ1 sodium solute IMCC3317_RS20435 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) IMCC3317_RS20465 ENOG4107RZZ dna polymerase iii epsilon subunit IMCC3317_RS20475 ENOG4105ERH Fumarylacetoacetate hydrolase IMCC3317_RS20485 ENOG4105CEV competence damage-inducible protein IMCC3317_RS20490 ENOG4105KDC 50s ribosomal protein l28 IMCC3317_RS20495 ENOG41083ND 50S ribosomal protein L33 IMCC3317_RS20505 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) IMCC3317_RS20540 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) IMCC3317_RS20555 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) IMCC3317_RS20565 ENOG41074B2 UPF0747 protein IMCC3317_RS20580 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) IMCC3317_RS20600 ENOG4105VRT cytoplasmic protein IMCC3317_RS20635 ENOG4105CP2 von willebrand factor, type a IMCC3317_RS20640 ENOG4107QX3 carboxylase IMCC3317_RS20655 ENOG4105NTK Transcriptional repressor Mpra IMCC3317_RS20660 ENOG4105EUB pirin domain protein IMCC3317_RS20665 ENOG4105C2I pirin domain protein IMCC3317_RS20680 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase IMCC3317_RS20700 ENOG4105I6B RNA polymerase IMCC3317_RS20745 ENOG4105C5H ABC transporter IMCC3317_RS20760 ENOG4105CMM transposase IMCC3317_RS20800 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B IMCC3317_RS20805 ENOG4108K8S endonuclease I IMCC3317_RS20820 ENOG4105CI2 imidazolone-5-propionate hydrolase IMCC3317_RS20845 ENOG4108MGY Histidine kinase IMCC3317_RS20850 ENOG4105BZU Histidine kinase IMCC3317_RS20895 ENOG4105EMN RNA polymerase sigma factor IMCC3317_RS20900 ENOG4105BZ1 (ABC) transporter IMCC3317_RS20915 ENOG4105CKK Glycosyl transferase, family 2 IMCC3317_RS20925 ENOG41081WG 50s ribosomal protein l31 IMCC3317_RS20940 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen IMCC3317_RS20960 ENOG410600T transposase IMCC3317_RS20970 ENOG4108J59 Extracellular solute-binding protein, family 5 IMCC3317_RS20975 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) IMCC3317_RS20980 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) IMCC3317_RS20985 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins IMCC3317_RS21025 ENOG4107Z36 nucleotidyl transferase IMCC3317_RS21035 ENOG4105D17 glycoside hydrolase, family 3 domain protein IMCC3317_RS21050 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) IMCC3317_RS21060 ENOG4105EA8 2-Nitropropane dioxygenase IMCC3317_RS21085 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E IMCC3317_RS21090 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) IMCC3317_RS21100 ENOG4105CMV Succinyl-CoA synthetase subunit beta IMCC3317_RS21120 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) IMCC3317_RS21150 ENOG4105VEQ Cold shock protein IMCC3317_RS21155 ENOG4105DA5 (ABC) transporter IMCC3317_RS21170 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) IMCC3317_RS21190 ENOG410600T transposase IMCC3317_RS21210 ENOG4105CJ1 ABC, transporter IMCC3317_RS21225 ENOG4107SF2 Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) IMCC3317_RS21230 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate IMCC3317_RS21235 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) IMCC3317_RS21255 ENOG4108TJN glycosyl transferase group 1 IMCC3317_RS21260 ENOG4106WTF Glycosyl transferase, family 2 IMCC3317_RS21265 ENOG4107BJW polysaccharide deacetylase IMCC3317_RS21275 ENOG4105CKK Glycosyl transferase, family 2 IMCC3317_RS21285 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) IMCC3317_RS21300 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) IMCC3317_RS21325 ENOG4107ZNS Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) IMCC3317_RS21330 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) IMCC3317_RS21350 ENOG4105DXN mazG family IMCC3317_RS21380 ENOG4105C8Y Acetylornithine aminotransferase IMCC3317_RS21390 ENOG4107RAN Peptidase, M16 IMCC3317_RS21395 ENOG4107QJE Chromosome Partitioning Protein IMCC3317_RS21400 ENOG4105FA0 parb-like partition protein IMCC3317_RS21410 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) IMCC3317_RS21415 ENOG4105C3F Signal peptidase i IMCC3317_RS21455 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) IMCC3317_RS21465 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis IMCC3317_RS21480 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) IMCC3317_RS21485 ENOG4108RWN rrna methyltransferase IMCC3317_RS21505 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) IMCC3317_RS21510 ENOG4105CD3 dihydroorotase IMCC3317_RS21525 ENOG4105CIN aminoacyl-histidine dipeptidase IMCC3317_RS21545 ENOG4107XH4 PPIases accelerate the folding of proteins (By similarity) IMCC3317_RS21555 ENOG4105SFS phosphoesterase RecJ domain protein IMCC3317_RS21560 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) IMCC3317_RS21580 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) IMCC3317_RS21590 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) IMCC3317_RS21610 ENOG4105C7H Helicase, RecD TraA family IMCC3317_RS21615 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) IMCC3317_RS21630 ENOG4107RJC Iron-containing alcohol dehydrogenase IMCC3317_RS21645 ENOG4105D5P Methylmalonyl-coA mutase IMCC3317_RS21660 ENOG4105DBI uridine monophosphokinase IMCC3317_RS21715 ENOG4105C3M thioredoxin reductase IMCC3317_RS21760 ENOG4105C5Q Transcriptional regulator IMCC3317_RS21765 ENOG4108RMU ferritin dps family protein IMCC3317_RS21790 ENOG4105C7R Atpase associated with various cellular activities aaa_3 IMCC3317_RS21815 ENOG4105EN6 Membrane IMCC3317_RS21820 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) IMCC3317_RS21865 ENOG4105S2T inner membrane protein YbcI IMCC3317_RS21960 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) IMCC3317_RS21965 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) IMCC3317_RS21985 ENOG4105DJ4 phosphatidylserine decarboxylase IMCC3317_RS22010 ENOG4105D64 Mechanosensitive ion channel IMCC3317_RS22015 ENOG4105D7N magnesium and cobalt transport protein CorA IMCC3317_RS22030 ENOG4105E5N succinylglutamate desuccinylase aspartoacylase IMCC3317_RS22035 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) IMCC3317_RS22040 ENOG4105CKD glutathione-regulated potassium-efflux system protein IMCC3317_RS22060 ENOG4105C37 (CBS) domain IMCC3317_RS22085 ENOG4108HRK Histidine kinase IMCC3317_RS22100 ENOG4105DY9 regulatoR IMCC3317_RS22110 ENOG4105DY9 regulatoR IMCC3317_RS22140 ENOG4107SP2 The ortholog in A.thaliana is involved in photosystem II (PSII) assembly, but knockout of the corresponding gene in Synechoccus PCC 7002 has no effect on PSII activity IMCC3317_RS22145 ENOG4105CI2 imidazolone-5-propionate hydrolase IMCC3317_RS22150 ENOG4105M08 Membrane IMCC3317_RS22160 ENOG41090HT Inherit from COG: transposase IMCC3317_RS22165 ENOG4105W5Q DNA repair protein (RadC IMCC3317_RS22180 ENOG4108RCM Nitroreductase IMCC3317_RS22190 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase IMCC3317_RS22200 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) IMCC3317_RS22215 ENOG4105CNU cell division protein FtsK IMCC3317_RS22240 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) IMCC3317_RS22245 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) IMCC3317_RS22260 ENOG4105D3R alkyl hydroperoxide reductase IMCC3317_RS22265 ENOG4105DFD Na H antiporter IMCC3317_RS22280 ENOG4105C28 cystathionine IMCC3317_RS22285 ENOG4105EW9 transcriptional regulator AsnC family IMCC3317_RS22315 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) IMCC3317_RS22320 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) IMCC3317_RS22325 ENOG4105VEJ Heat shock protein IMCC3317_RS22345 ENOG4108HHA Transketolase IMCC3317_RS22380 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) IMCC3317_RS22395 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) IMCC3317_RS22400 ENOG4105CDU Replicative dna helicase IMCC3317_RS22430 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) IMCC3317_RS22435 ENOG4105VJV 50s ribosomal protein L35 IMCC3317_RS22440 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) IMCC3317_RS22445 ENOG4105C22 threonyL-tRNA synthetase IMCC3317_RS22450 ENOG4105W5Q DNA repair protein (RadC IMCC3317_RS22455 ENOG4105ETE Transcriptional regulator (LacI family IMCC3317_RS22460 ENOG4105CMR udp-glucose 4-epimerase IMCC3317_RS22475 ENOG4107RUZ Sss sodium solute transporter superfamily IMCC3317_RS22480 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) IMCC3317_RS22485 ENOG4105F0Z galactose-1-phosphate uridylyltransferase IMCC3317_RS22490 ENOG4105E6M Sulphatase-modifying factor protein IMCC3317_RS22495 ENOG4105C26 Dehydrogenase IMCC3317_RS22500 ENOG4105DIA mandelate racemase muconate lactonizing IMCC3317_RS22520 ENOG4105C27 TonB-dependent Receptor Plug IMCC3317_RS22525 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) IMCC3317_RS22540 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 IMCC3317_RS22550 ENOG4105CF7 AraC family transcriptional regulator IMCC3317_RS22555 ENOG4105ENH Sulfatase IMCC3317_RS22570 ENOG4107QNK )-transporter IMCC3317_RS22580 ENOG4105C4C beta-galactosidase IMCC3317_RS22600 ENOG4105CBG Sulfatase IMCC3317_RS22615 ENOG4105ENH Sulfatase IMCC3317_RS22620 ENOG4105CPC Aldo Keto reductase IMCC3317_RS22625 ENOG4105BZU Histidine kinase IMCC3317_RS22655 ENOG4105CBG Sulfatase IMCC3317_RS22660 ENOG41084I7 Alpha-galactosidase. Removes both branched alpha-1,3- linked galactose residues of blood group B antigens and linear alpha-1,3-linked galactose structures IMCC3317_RS22670 ENOG4105CBG Sulfatase IMCC3317_RS22725 ENOG4105ENH Sulfatase IMCC3317_RS22730 ENOG4105CBG Sulfatase IMCC3317_RS22745 ENOG4105C27 TonB-dependent Receptor Plug IMCC3317_RS22760 ENOG41061MV Arylsulfatase IMCC3317_RS22825 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate IMCC3317_RS22840 ENOG4105EYW Ion transport protein IMCC3317_RS22860 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) IMCC3317_RS22865 ENOG4108JA1 polyketide synthase IMCC3317_RS22870 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) IMCC3317_RS22910 ENOG4108U51 Universal stress protein IMCC3317_RS22915 ENOG4105BZU Histidine kinase IMCC3317_RS22920 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family IMCC3317_RS22930 ENOG4105D82 Glutamate dehydrogenase IMCC3317_RS22955 ENOG4105E9K Isocitrate dehydrogenase IMCC3317_RS22960 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) IMCC3317_RS22970 ENOG4107QN2 dihydrolipoyl dehydrogenase IMCC3317_RS22980 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen IMCC3317_RS23000 ENOG4105EWK phytoene IMCC3317_RS23015 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin IMCC3317_RS23030 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) IMCC3317_RS23040 ENOG4105E0R Deoxyhypusine synthase IMCC3317_RS23060 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase IMCC3317_RS23065 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) IMCC3317_RS23130 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) IMCC3317_RS23155 ENOG4105C0H protease IMCC3317_RS23160 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)