locus-tag	class	description
A0U89_RS00010	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A0U89_RS00015	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
A0U89_RS00020	COG1091	dTDP-4-dehydrorhamnose reductase activity
A0U89_RS00030	COG0564	pseudouridine synthase activity
A0U89_RS00035	COG1674	ftsk spoiiie
A0U89_RS00040	COG0742	ribosomal rna small subunit methyltransferase
A0U89_RS00045	COG1187	pseudouridine synthase activity
A0U89_RS00050	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A0U89_RS00055	COG0590	tRNA wobble adenosine to inosine editing
A0U89_RS00070	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A0U89_RS00085	COG0366	Alpha amylase catalytic
A0U89_RS00090	COG1621	beta-fructofuranosidase activity
A0U89_RS00100	COG1879	ABC-type sugar transport system periplasmic component
A0U89_RS00105	COG1172	Belongs to the binding-protein-dependent transport system permease family
A0U89_RS00115	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A0U89_RS00140	COG2066	Belongs to the glutaminase family
A0U89_RS00180	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A0U89_RS00185	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A0U89_RS00205	COG1051	belongs to the nudix hydrolase family
A0U89_RS00215	COG0508	dehydrogenase complex catalyzes the overall conversion of
A0U89_RS00220	COG1070	Carbohydrate kinase
A0U89_RS00225	COG1073	alpha beta
A0U89_RS00235	COG2814	Major facilitator Superfamily
A0U89_RS00270	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A0U89_RS00275	COG1127	ABC transporter
A0U89_RS00310	COG0656	L-ascorbic acid biosynthetic process
A0U89_RS00320	COG0305	Participates in initiation and elongation during chromosome replication
A0U89_RS00325	COG1285	pathogenesis
A0U89_RS00345	COG0584	glycerophosphoryl diester phosphodiesterase
A0U89_RS00355	COG3047	cAMP biosynthetic process
A0U89_RS00360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A0U89_RS00370	COG0194	GDP metabolic process
A0U89_RS00375	COG0300	oxidoreductase activity
A0U89_RS00385	COG0823	Involved in the tonB-independent uptake of proteins
A0U89_RS00385	COG1506	peptidase
A0U89_RS00385	COG4946	Tricorn protease homolog
A0U89_RS00400	COG0494	nUDIX hydrolase
A0U89_RS00405	COG0326	Molecular chaperone. Has ATPase activity
A0U89_RS00425	COG0420	3'-5' exonuclease activity
A0U89_RS00435	COG0025	NhaP-type Na H and K H
A0U89_RS00440	COG4191	Histidine kinase
A0U89_RS00440	COG0784	Response regulator, receiver
A0U89_RS00480	COG1215	transferase activity, transferring glycosyl groups
A0U89_RS00485	COG0438	transferase activity, transferring glycosyl groups
A0U89_RS00485	COG1216	Glycosyl transferase, family 2
A0U89_RS00495	COG1530	ribonuclease E activity
A0U89_RS00500	COG0424	maF-like protein
A0U89_RS00505	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A0U89_RS00510	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A0U89_RS00515	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A0U89_RS00525	COG0330	HflC and HflK could
A0U89_RS00545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A0U89_RS00560	COG4774	siderophore transport
A0U89_RS00575	COG1131	(ABC) transporter
A0U89_RS00580	COG1678	Uncharacterized ACR, COG1678
A0U89_RS00585	COG4221	oxidoreductase activity
A0U89_RS00590	COG2326	polyphosphate kinase activity
A0U89_RS00600	COG0405	Gamma-glutamyltransferase
A0U89_RS00605	COG1338	Plays a role in the flagellum-specific transport system
A0U89_RS00615	COG1815	bacterial-type flagellum-dependent cell motility
A0U89_RS00620	COG1558	bacterial-type flagellum-dependent cell motility
A0U89_RS00625	COG1677	Flagellar hook-basal body complex protein FliE
A0U89_RS00630	COG1987	bacterial-type flagellum assembly
A0U89_RS00635	COG1684	flagellar biosynthetic protein fliR
A0U89_RS00640	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A0U89_RS00660	COG0740	serine-type endopeptidase activity
A0U89_RS00670	COG0436	Aminotransferase
A0U89_RS00680	COG1494	fructose-1,6-bisphosphatase
A0U89_RS00685	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A0U89_RS00695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A0U89_RS00715	COG0513	Belongs to the DEAD box helicase family
A0U89_RS00720	COG1289	transmembrane transporter activity
A0U89_RS00735	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A0U89_RS00740	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A0U89_RS00745	COG0552	protein localization to endoplasmic reticulum
A0U89_RS00750	COG2271	Major facilitator Superfamily
A0U89_RS00755	COG1063	alcohol dehydrogenase
A0U89_RS00765	COG0126	phosphoglycerate kinase activity
A0U89_RS00785	COG0438	transferase activity, transferring glycosyl groups
A0U89_RS00790	COG4191	Histidine kinase
A0U89_RS00790	COG0784	Response regulator, receiver
A0U89_RS00805	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A0U89_RS00820	COG2010	Cytochrome c
A0U89_RS00820	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A0U89_RS00830	COG0746	molybdenum cofactor guanylyltransferase activity
A0U89_RS00840	COG3585	molybdate ion transport
A0U89_RS00845	COG0649	NAD binding
A0U89_RS00845	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A0U89_RS00845	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A0U89_RS00875	COG0656	L-ascorbic acid biosynthetic process
A0U89_RS00890	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A0U89_RS00895	COG0730	response to heat
A0U89_RS00900	COG0314	molybdopterin synthase activity
A0U89_RS00910	COG0315	cyclic pyranopterin monophosphate synthase activity
A0U89_RS00920	COG0303	'Molybdopterin
A0U89_RS00925	COG3608	succinylglutamate desuccinylase aspartoacylase
A0U89_RS00925	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A0U89_RS00930	COG1566	PFAM secretion protein HlyD family protein
A0U89_RS00935	COG2814	Major facilitator Superfamily
A0U89_RS00945	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A0U89_RS00950	COG3387	PFAM Glycoside hydrolase 15-related
A0U89_RS00955	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A0U89_RS00960	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A0U89_RS00965	COG0649	NAD binding
A0U89_RS00965	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A0U89_RS00980	COG1034	ATP synthesis coupled electron transport
A0U89_RS00985	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A0U89_RS00995	COG0839	Belongs to the complex I subunit 6 family
A0U89_RS01000	COG0713	ATP synthesis coupled electron transport
A0U89_RS01015	COG1007	ATP synthesis coupled electron transport
A0U89_RS01040	COG1129	ABC transporter
A0U89_RS01045	COG1172	Belongs to the binding-protein-dependent transport system permease family
A0U89_RS01050	COG1879	ABC-type sugar transport system periplasmic component
A0U89_RS01055	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A0U89_RS01060	COG1349	DNA-binding transcription factor activity
A0U89_RS01070	COG0738	Major facilitator superfamily
A0U89_RS01075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A0U89_RS01090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A0U89_RS01100	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A0U89_RS01115	COG4774	siderophore transport
A0U89_RS01120	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
A0U89_RS01145	COG0156	8-amino-7-oxononanoate synthase activity
A0U89_RS01150	COG1028	Short-chain dehydrogenase reductase Sdr
A0U89_RS01155	COG0671	phosphoesterase, PA-phosphatase related
A0U89_RS01165	COG0529	Catalyzes the synthesis of activated sulfate
A0U89_RS01165	COG2895	sulfate adenylyltransferase (ATP) activity
A0U89_RS01170	COG0175	sulfate reduction
A0U89_RS01175	COG0175	sulfate reduction
A0U89_RS01180	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A0U89_RS01180	COG1648	precorrin-2 dehydrogenase activity
A0U89_RS01185	COG2010	Cytochrome c
A0U89_RS01185	COG4993	Dehydrogenase
A0U89_RS01200	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A0U89_RS01205	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A0U89_RS01210	COG0297	glycogen (starch) synthase activity
A0U89_RS01230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A0U89_RS01235	COG0640	Transcriptional regulator
A0U89_RS01240	COG0450	alkyl hydroperoxide reductase
A0U89_RS01260	COG1956	GAF domain-containing protein
A0U89_RS01285	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A0U89_RS01295	COG4214	carbohydrate transport
A0U89_RS01305	COG4213	ABC transporter substrate-binding protein
A0U89_RS01310	COG0776	regulation of translation
A0U89_RS01320	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A0U89_RS01390	COG1127	ABC transporter
A0U89_RS01395	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A0U89_RS01405	COG2132	Multicopper oxidase
A0U89_RS01425	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A0U89_RS01455	COG1012	belongs to the aldehyde dehydrogenase family
A0U89_RS01465	COG1573	uracil-dna glycosylase
A0U89_RS01475	COG0438	transferase activity, transferring glycosyl groups
A0U89_RS01500	COG0655	NAD(P)H dehydrogenase (quinone) activity
A0U89_RS01525	COG0583	DNA-binding transcription factor activity
A0U89_RS01535	COG0574	Belongs to the PEP-utilizing enzyme family
A0U89_RS01535	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A0U89_RS01540	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A0U89_RS01550	COG0646	methionine synthase
A0U89_RS01550	COG1410	methionine synthase
A0U89_RS01555	COG0604	alcohol dehydrogenase
A0U89_RS01560	COG0668	transmembrane transport
A0U89_RS01570	COG1172	Belongs to the binding-protein-dependent transport system permease family
A0U89_RS01575	COG1129	ABC transporter
A0U89_RS01580	COG1879	ABC-type sugar transport system periplasmic component
A0U89_RS01585	COG1028	Short-chain dehydrogenase reductase Sdr
A0U89_RS01595	COG1063	alcohol dehydrogenase
A0U89_RS01610	COG2801	Transposase and inactivated derivatives
A0U89_RS01635	COG3415	Transposase
A0U89_RS01635	COG2801	Transposase and inactivated derivatives
A0U89_RS01645	COG0583	DNA-binding transcription factor activity
A0U89_RS01650	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A0U89_RS01665	COG0511	ligase activity, forming carbon-carbon bonds
A0U89_RS01670	COG4221	oxidoreductase activity
A0U89_RS01680	COG2801	Transposase and inactivated derivatives
A0U89_RS01690	COG0135	phosphoribosylanthranilate isomerase activity
A0U89_RS01695	COG0284	orotidine-5'-phosphate decarboxylase activity
A0U89_RS01710	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A0U89_RS01725	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A0U89_RS01730	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A0U89_RS01755	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A0U89_RS01770	COG0469	pyruvate kinase activity
A0U89_RS01775	COG0287	Prephenate dehydrogenase
A0U89_RS01785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A0U89_RS01790	COG1215	transferase activity, transferring glycosyl groups
A0U89_RS01795	COG1562	ergosterol biosynthetic process
A0U89_RS01810	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A0U89_RS01825	COG1562	ergosterol biosynthetic process
A0U89_RS01830	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A0U89_RS01835	COG1657	PFAM Prenyltransferase squalene oxidase
A0U89_RS01850	COG1012	belongs to the aldehyde dehydrogenase family
A0U89_RS01870	COG2252	PERMEase
A0U89_RS01900	COG3547	Transposase (IS116 IS110 IS902 family)
A0U89_RS01910	COG0481	GTPase activity
A0U89_RS01930	COG0483	inositol monophosphate 1-phosphatase activity
A0U89_RS01935	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A0U89_RS01955	COG1509	lysine 2,3-aminomutase activity
A0U89_RS01960	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
A0U89_RS02000	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A0U89_RS02005	COG1692	metallophosphoesterase
A0U89_RS02010	COG5443	negative regulation of bacterial-type flagellum assembly
A0U89_RS02065	COG3547	Transposase (IS116 IS110 IS902 family)
A0U89_RS02090	COG0583	DNA-binding transcription factor activity
A0U89_RS02110	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A0U89_RS02125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A0U89_RS02145	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A0U89_RS02155	COG3511	phospholipase C
A0U89_RS02160	COG0673	inositol 2-dehydrogenase activity
A0U89_RS02165	COG4213	ABC transporter substrate-binding protein
A0U89_RS02175	COG4214	carbohydrate transport
A0U89_RS02180	COG2271	Major facilitator Superfamily
A0U89_RS02215	COG2226	methyltransferase
A0U89_RS02230	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A0U89_RS02250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A0U89_RS02270	COG0723	plastoquinol--plastocyanin reductase activity
A0U89_RS02275	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A0U89_RS02280	COG2857	Cytochrome c1
A0U89_RS02375	COG3191	aminopeptidase activity
A0U89_RS02385	COG4771	TonB-dependent receptor
A0U89_RS02395	COG1295	ribonuclease BN
A0U89_RS02410	COG0511	ligase activity, forming carbon-carbon bonds
A0U89_RS02415	COG0439	Biotin carboxylase
A0U89_RS02425	COG0793	Belongs to the peptidase S41A family
A0U89_RS02425	COG4946	Tricorn protease homolog
A0U89_RS02430	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A0U89_RS02435	COG4133	protoheme IX ABC transporter activity
A0U89_RS02440	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A0U89_RS02445	COG1126	abc transporter atp-binding protein
A0U89_RS02450	COG0765	amino acid transport
A0U89_RS02460	COG0542	response to heat
A0U89_RS02470	COG0779	Required for maturation of 30S ribosomal subunits
A0U89_RS02485	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A0U89_RS02490	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A0U89_RS02495	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A0U89_RS02500	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A0U89_RS02505	COG1185	polyribonucleotide nucleotidyltransferase activity
A0U89_RS02530	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A0U89_RS02535	COG3158	transport of potassium into the cell
A0U89_RS02540	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A0U89_RS02550	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A0U89_RS02565	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A0U89_RS02570	COG2945	thiolester hydrolase activity
A0U89_RS02575	COG1104	cysteine desulfurase activity
A0U89_RS02580	COG1104	cysteine desulfurase activity
A0U89_RS02590	COG0482	sulfurtransferase activity
A0U89_RS02610	COG1706	bacterial-type flagellum-dependent cell motility
A0U89_RS02630	COG0753	catalase activity
A0U89_RS02655	COG0024	Methionine aminopeptidase
A0U89_RS02675	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A0U89_RS02680	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A0U89_RS02685	COG1028	Short-chain dehydrogenase reductase Sdr
A0U89_RS02700	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A0U89_RS02705	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A0U89_RS02710	COG0539	negative regulation of cytoplasmic translation
A0U89_RS02720	COG1215	transferase activity, transferring glycosyl groups
A0U89_RS02730	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A0U89_RS02735	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A0U89_RS02740	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A0U89_RS02745	COG0505	Belongs to the CarA family
A0U89_RS02750	COG1610	YqeY-like protein
A0U89_RS02755	COG0358	DNA primase activity
A0U89_RS02760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A0U89_RS02770	COG0360	Binds together with S18 to 16S ribosomal RNA
A0U89_RS02775	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A0U89_RS02780	COG0359	binds to the 23S rRNA
A0U89_RS02785	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A0U89_RS02790	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A0U89_RS02800	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A0U89_RS02825	COG3088	subunit of a heme lyase
A0U89_RS02830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A0U89_RS02835	COG1138	Cytochrome C-type biogenesis protein
A0U89_RS02840	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
A0U89_RS02845	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A0U89_RS02860	COG1012	belongs to the aldehyde dehydrogenase family
A0U89_RS02875	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A0U89_RS02895	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A0U89_RS02910	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A0U89_RS02915	COG0564	pseudouridine synthase activity
A0U89_RS02930	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A0U89_RS02930	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A0U89_RS02935	COG2814	Major facilitator Superfamily
A0U89_RS02950	COG2967	ApaG domain
A0U89_RS02975	COG1252	NADH dehydrogenase
A0U89_RS02980	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A0U89_RS02985	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A0U89_RS02990	COG0653	protein targeting
A0U89_RS02995	COG0217	transcriptional regulatory protein
A0U89_RS03000	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A0U89_RS03005	COG0632	four-way junction helicase activity
A0U89_RS03010	COG2255	four-way junction helicase activity
A0U89_RS03015	COG0824	Thioesterase
A0U89_RS03020	COG0811	peptide transport
A0U89_RS03035	COG0823	Involved in the tonB-independent uptake of proteins
A0U89_RS03040	COG2885	chlorophyll binding
A0U89_RS03050	COG0037	tRNA processing
A0U89_RS03060	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A0U89_RS03065	COG0351	phosphomethylpyrimidine kinase
A0U89_RS03070	COG0745	RESPONSE REGULATOR receiver
A0U89_RS03095	COG2309	aminopeptidase activity
A0U89_RS03100	COG1403	HNH endonuclease
A0U89_RS03110	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A0U89_RS03130	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A0U89_RS03135	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A0U89_RS03140	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A0U89_RS03145	COG0561	phosphatase activity
A0U89_RS03150	COG0363	glucosamine-6-phosphate deaminase activity
A0U89_RS03155	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A0U89_RS03160	COG3265	gluconokinase activity
A0U89_RS03165	COG1671	Belongs to the UPF0178 family
A0U89_RS03170	COG0477	Major facilitator Superfamily
A0U89_RS03180	COG0346	lactoylglutathione lyase activity
A0U89_RS03190	COG0215	cysteine-tRNA ligase activity
A0U89_RS03205	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A0U89_RS03210	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A0U89_RS03215	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A0U89_RS03215	COG2885	chlorophyll binding
A0U89_RS03220	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A0U89_RS03230	COG4974	Belongs to the 'phage' integrase family
A0U89_RS03235	COG0825	malonyl-CoA metabolic process
A0U89_RS03240	COG1058	Belongs to the CinA family
A0U89_RS03240	COG1546	Belongs to the CinA family
A0U89_RS03260	COG4771	TonB-dependent receptor
A0U89_RS03270	COG1862	Preprotein translocase
A0U89_RS03275	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A0U89_RS03295	COG1758	RNA polymerase activity
A0U89_RS03300	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A0U89_RS03305	COG0736	holo-[acyl-carrier-protein] synthase activity
A0U89_RS03310	COG0681	Belongs to the peptidase S26 family
A0U89_RS03320	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A0U89_RS03325	COG0528	UMP kinase activity
A0U89_RS03330	COG0233	cytoplasmic translational termination
A0U89_RS03335	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A0U89_RS03345	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A0U89_RS03350	COG0750	zinc metalloprotease
A0U89_RS03355	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A0U89_RS03365	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A0U89_RS03370	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A0U89_RS03375	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A0U89_RS03380	COG3494	Protein of unknown function (DUF1009)
A0U89_RS03395	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A0U89_RS03400	COG0594	ribonuclease P activity
A0U89_RS03410	COG0706	membrane insertase activity
A0U89_RS03415	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A0U89_RS03420	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A0U89_RS03430	COG2171	N-acyltransferase activity
A0U89_RS03435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A0U89_RS03445	COG0101	tRNA pseudouridine synthase activity
A0U89_RS03450	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A0U89_RS03455	COG0242	peptide deformylase activity
A0U89_RS03470	COG0251	oxidation-reduction process
A0U89_RS03475	COG1137	ATPase activity
A0U89_RS03490	COG0517	IMP dehydrogenase activity
A0U89_RS03490	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A0U89_RS03525	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A0U89_RS03535	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A0U89_RS03550	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A0U89_RS03570	COG0556	nucleotide-excision repair
A0U89_RS03595	COG2226	methyltransferase
A0U89_RS03600	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A0U89_RS03605	COG0109	protoheme IX farnesyltransferase activity
A0U89_RS03615	COG0312	modulator of DNA gyrase
A0U89_RS03620	COG0612	Peptidase, M16
A0U89_RS03645	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A0U89_RS03650	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A0U89_RS03655	COG0728	peptidoglycan biosynthetic process
A0U89_RS03665	COG0386	Belongs to the glutathione peroxidase family
A0U89_RS03670	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A0U89_RS03690	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A0U89_RS03695	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A0U89_RS03700	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A0U89_RS03705	COG0181	hydroxymethylbilane synthase activity
A0U89_RS03735	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A0U89_RS03755	COG1858	cytochrome C peroxidase
A0U89_RS03770	COG0408	coproporphyrinogen oxidase activity
A0U89_RS03775	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A0U89_RS03780	COG1028	Short-chain dehydrogenase reductase Sdr
A0U89_RS03800	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A0U89_RS03805	COG0459	protein refolding
A0U89_RS03810	COG1199	ATP-dependent helicase activity
A0U89_RS03830	COG1573	uracil-dna glycosylase
A0U89_RS03840	COG0670	Belongs to the BI1 family
A0U89_RS03855	COG1845	cytochrome c oxidase, subunit III
A0U89_RS03860	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A0U89_RS03880	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A0U89_RS03890	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A0U89_RS03925	COG0628	permease
A0U89_RS03930	COG0488	(ABC) transporter
A0U89_RS03935	COG0105	UTP biosynthetic process
A0U89_RS03945	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A0U89_RS03950	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A0U89_RS03960	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A0U89_RS03975	COG1953	Uracil, thiamine, allantoin
A0U89_RS03985	COG3386	PFAM SMP-30 Gluconolaconase
A0U89_RS03990	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A0U89_RS03995	COG2814	Major facilitator Superfamily
A0U89_RS04020	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
A0U89_RS04035	COG1028	Short-chain dehydrogenase reductase Sdr
A0U89_RS04060	COG2072	flavoprotein involved in K transport
A0U89_RS04090	COG2351	hydroxyisourate hydrolase activity
A0U89_RS04105	COG0019	diaminopimelate decarboxylase activity
A0U89_RS04110	COG0295	cytidine deaminase activity
A0U89_RS04120	COG4191	Histidine kinase
A0U89_RS04120	COG0784	Response regulator, receiver
A0U89_RS04125	COG1028	Short-chain dehydrogenase reductase Sdr
A0U89_RS04145	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A0U89_RS04145	COG0519	Catalyzes the synthesis of GMP from XMP
A0U89_RS04155	COG1393	Belongs to the ArsC family
A0U89_RS04205	COG0438	transferase activity, transferring glycosyl groups
A0U89_RS04230	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A0U89_RS04235	COG0165	Argininosuccinate lyase
A0U89_RS04245	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A0U89_RS04250	COG0237	dephospho-CoA kinase activity
A0U89_RS04265	COG0438	transferase activity, transferring glycosyl groups
A0U89_RS04270	COG0367	asparagine synthase
A0U89_RS04275	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A0U89_RS04300	COG1160	GTP binding
A0U89_RS04310	COG1028	Short-chain dehydrogenase reductase Sdr
A0U89_RS04320	COG2814	Major facilitator Superfamily
A0U89_RS04330	COG2814	Major facilitator Superfamily
A0U89_RS04350	COG3572	ergothioneine biosynthetic process
A0U89_RS04355	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A0U89_RS04360	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A0U89_RS04380	COG1663	tetraacyldisaccharide 4'-kinase activity
A0U89_RS04385	COG1519	Transferase
A0U89_RS04395	COG0259	pyridoxamine-phosphate oxidase activity
A0U89_RS04400	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A0U89_RS04405	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A0U89_RS04410	COG1764	response to oxidative stress
A0U89_RS04415	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A0U89_RS04415	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A0U89_RS04425	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A0U89_RS04435	COG0142	geranyltranstransferase activity
A0U89_RS04440	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A0U89_RS04445	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A0U89_RS04465	COG0287	Prephenate dehydrogenase
A0U89_RS04465	COG1605	Chorismate mutase
A0U89_RS04470	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A0U89_RS04480	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A0U89_RS04485	COG1253	flavin adenine dinucleotide binding
A0U89_RS04490	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A0U89_RS04495	COG1702	phosphate starvation-inducible protein PhoH
A0U89_RS04500	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A0U89_RS04510	COG0729	surface antigen
A0U89_RS04535	COG1028	Short-chain dehydrogenase reductase Sdr
A0U89_RS04540	COG1329	Transcriptional regulator
A0U89_RS04550	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
A0U89_RS04555	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A0U89_RS04565	COG0432	Pfam Uncharacterised protein family UPF0047
A0U89_RS04570	COG0180	Tryptophanyl-tRNA synthetase
A0U89_RS04575	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A0U89_RS04590	COG0545	Peptidyl-prolyl cis-trans isomerase
A0U89_RS04595	COG0137	argininosuccinate synthase activity
A0U89_RS04600	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A0U89_RS04605	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A0U89_RS04610	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A0U89_RS04615	COG0142	geranyltranstransferase activity
A0U89_RS04620	COG1722	exodeoxyribonuclease VII activity
A0U89_RS04630	COG1940	carbohydrate kinase activity
A0U89_RS04635	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A0U89_RS04650	COG3588	fructose-bisphosphate aldolase
A0U89_RS04675	COG5001	Diguanylate cyclase
A0U89_RS04675	COG3300	MHYT domain
A0U89_RS04695	COG1278	Cold shock
A0U89_RS04710	COG0583	DNA-binding transcription factor activity
A0U89_RS04720	COG0579	oxidoreductase
A0U89_RS04730	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A0U89_RS04745	COG0508	dehydrogenase complex catalyzes the overall conversion of
A0U89_RS04755	COG0473	3-isopropylmalate dehydrogenase activity
A0U89_RS04775	COG1053	succinate dehydrogenase
A0U89_RS04780	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A0U89_RS04790	COG0114	fumarate hydratase activity
A0U89_RS04795	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A0U89_RS04805	COG0022	dehydrogenase e1 component
A0U89_RS04810	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A0U89_RS04820	COG2755	lipolytic protein G-D-S-L family
A0U89_RS04820	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A0U89_RS04895	COG1475	DNA binding
A0U89_RS04915	COG4974	Belongs to the 'phage' integrase family
A0U89_RS04920	COG0517	IMP dehydrogenase activity
A0U89_RS04930	COG2084	Dehydrogenase
A0U89_RS04940	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A0U89_RS04945	COG0583	DNA-binding transcription factor activity
A0U89_RS04950	COG1028	Short-chain dehydrogenase reductase Sdr
A0U89_RS04965	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A0U89_RS04975	COG3547	Transposase (IS116 IS110 IS902 family)
A0U89_RS04980	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A0U89_RS05000	COG2801	Transposase and inactivated derivatives
A0U89_RS05005	COG0024	Methionine aminopeptidase
A0U89_RS05015	COG3547	Transposase (IS116 IS110 IS902 family)
A0U89_RS05020	COG1193	negative regulation of DNA recombination
A0U89_RS05025	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A0U89_RS05065	COG0697	spore germination
A0U89_RS05070	COG1596	polysaccharide export
A0U89_RS05115	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A0U89_RS05125	COG1216	Glycosyl transferase, family 2
A0U89_RS05130	COG0438	transferase activity, transferring glycosyl groups
A0U89_RS05135	COG0438	transferase activity, transferring glycosyl groups
A0U89_RS05160	COG2244	polysaccharide biosynthetic process
A0U89_RS05200	COG1129	ABC transporter
A0U89_RS05205	COG1172	Belongs to the binding-protein-dependent transport system permease family
A0U89_RS05245	COG4792	protein secretion
A0U89_RS05250	COG4791	protein targeting
A0U89_RS05260	COG4790	Type iii secretion
A0U89_RS05275	COG1157	protein secretion by the type III secretion system
A0U89_RS05290	COG4669	(LipO)protein
A0U89_RS05300	COG1450	Type ii and iii secretion system protein
A0U89_RS05330	COG4789	Type iii secretion
A0U89_RS05335	COG0745	RESPONSE REGULATOR receiver
A0U89_RS05340	COG4964	Belongs to the GSP D family
A0U89_RS05370	COG1321	iron dependent repressor
A0U89_RS05375	COG1914	H( )-stimulated, divalent metal cation uptake system
A0U89_RS05435	COG2130	NADP-dependent
A0U89_RS05455	COG3547	Transposase (IS116 IS110 IS902 family)
A0U89_RS05520	COG0732	type I restriction modification DNA specificity domain
A0U89_RS05530	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
A0U89_RS05585	COG3293	Transposase
A0U89_RS05650	COG0210	DNA helicase
A0U89_RS05690	COG0140	phosphoribosyl-ATP diphosphatase activity
A0U89_RS05695	COG0107	imidazoleglycerol-phosphate synthase activity
A0U89_RS05700	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A0U89_RS05705	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A0U89_RS05715	COG0131	Imidazoleglycerol-phosphate dehydratase
A0U89_RS05720	COG0778	Nitroreductase
A0U89_RS05740	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A0U89_RS05740	COG3264	Mechanosensitive ion channel
A0U89_RS05745	COG0167	dihydroorotate dehydrogenase activity
A0U89_RS05755	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A0U89_RS05760	COG2076	Multidrug Resistance protein
A0U89_RS05775	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A0U89_RS05785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A0U89_RS05820	COG1766	The M ring may be actively involved in energy transduction
A0U89_RS05825	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A0U89_RS05835	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A0U89_RS05840	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A0U89_RS05845	COG2963	transposase activity
A0U89_RS05850	COG3436	PFAM IS66 Orf2 family protein
A0U89_RS05855	COG2433	Pfam Transposase IS66
A0U89_RS05860	COG3318	Belongs to the UPF0149 family
A0U89_RS05860	COG3012	SEC-C Motif Domain Protein
A0U89_RS05865	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A0U89_RS05875	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A0U89_RS05885	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A0U89_RS05900	COG0667	Aldo Keto reductase
A0U89_RS05915	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A0U89_RS05935	COG0488	(ABC) transporter
A0U89_RS05960	COG1028	Short-chain dehydrogenase reductase Sdr
A0U89_RS05995	COG1201	RNA secondary structure unwinding
A0U89_RS06005	COG1793	dna ligase
A0U89_RS06005	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A0U89_RS06025	COG4555	ABC transporter
A0U89_RS06040	COG2271	Major facilitator Superfamily
A0U89_RS06050	COG2271	Major facilitator Superfamily
A0U89_RS06055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A0U89_RS06060	COG0583	DNA-binding transcription factor activity
A0U89_RS06065	COG2070	2-Nitropropane dioxygenase
A0U89_RS06070	COG2814	Major facilitator Superfamily
A0U89_RS06075	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
A0U89_RS06080	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A0U89_RS06105	COG1797	cobyrinic acid a,c-diamide synthase activity
A0U89_RS06110	COG2875	Belongs to the precorrin methyltransferase family
A0U89_RS06120	COG2099	Precorrin-6x reductase
A0U89_RS06140	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A0U89_RS06160	COG1492	cobalamin metabolic process
A0U89_RS06165	COG0778	Nitroreductase
A0U89_RS06170	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
A0U89_RS06185	COG0583	DNA-binding transcription factor activity
A0U89_RS06215	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A0U89_RS06280	COG3547	Transposase (IS116 IS110 IS902 family)
A0U89_RS06310	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A0U89_RS06315	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A0U89_RS06315	COG2169	Transcriptional regulator
A0U89_RS06340	COG0521	Mo-molybdopterin cofactor biosynthetic process
A0U89_RS06350	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A0U89_RS06355	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A0U89_RS06355	COG2813	Specifically methylates the guanine in position
A0U89_RS06360	COG2971	BadF BadG BcrA BcrD
A0U89_RS06365	COG0778	Nitroreductase
A0U89_RS06370	COG0513	Belongs to the DEAD box helicase family
A0U89_RS06380	COG3961	Belongs to the TPP enzyme family
A0U89_RS06390	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A0U89_RS06395	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
A0U89_RS06405	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A0U89_RS06410	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A0U89_RS06415	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A0U89_RS06420	COG0625	glutathione transferase activity
A0U89_RS06425	COG1028	Short-chain dehydrogenase reductase Sdr
A0U89_RS06455	COG3547	Transposase (IS116 IS110 IS902 family)
A0U89_RS06460	COG0129	dihydroxy-acid dehydratase activity
A0U89_RS06465	COG0800	Aldolase
A0U89_RS06470	COG2814	Major facilitator Superfamily
A0U89_RS06475	COG1566	PFAM secretion protein HlyD family protein
A0U89_RS06490	COG0138	bifunctional purine biosynthesis protein purh
A0U89_RS06515	COG0667	Aldo Keto reductase
A0U89_RS06540	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A0U89_RS06540	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A0U89_RS06555	COG0745	RESPONSE REGULATOR receiver
A0U89_RS06570	COG0322	excinuclease ABC activity
A0U89_RS06575	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A0U89_RS06585	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A0U89_RS06590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A0U89_RS06600	COG0148	phosphopyruvate hydratase activity
A0U89_RS06615	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A0U89_RS06620	COG0504	CTP synthase activity
A0U89_RS06630	COG0149	triose-phosphate isomerase activity
A0U89_RS06640	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A0U89_RS06650	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A0U89_RS06655	COG0134	indole-3-glycerol-phosphate synthase activity
A0U89_RS06660	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A0U89_RS06665	COG0022	dehydrogenase e1 component
A0U89_RS06665	COG0508	dehydrogenase complex catalyzes the overall conversion of
A0U89_RS06670	COG0508	dehydrogenase complex catalyzes the overall conversion of
A0U89_RS06675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A0U89_RS06680	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A0U89_RS06685	COG2867	negative regulation of translational initiation
A0U89_RS06700	COG0741	lytic transglycosylase activity
A0U89_RS06705	COG0861	Integral membrane protein TerC family
A0U89_RS06710	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A0U89_RS06715	COG2814	Major facilitator Superfamily
A0U89_RS06720	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A0U89_RS06735	COG0047	phosphoribosylformylglycinamidine synthase activity
A0U89_RS06740	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A0U89_RS06745	COG0271	Belongs to the BolA IbaG family
A0U89_RS06750	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A0U89_RS06760	COG0792	nuclease activity
A0U89_RS06765	COG0113	porphobilinogen synthase activity
A0U89_RS06770	COG0531	amino acid
A0U89_RS06775	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A0U89_RS06820	COG3012	SEC-C Motif Domain Protein
A0U89_RS06820	COG3318	Belongs to the UPF0149 family
A0U89_RS06825	COG2433	Pfam Transposase IS66
A0U89_RS06830	COG3436	PFAM IS66 Orf2 family protein
A0U89_RS06835	COG2963	transposase activity
A0U89_RS06860	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A0U89_RS06865	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A0U89_RS06870	COG0154	amidase activity
A0U89_RS06875	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A0U89_RS06985	COG4386	tail sheath protein
A0U89_RS07110	COG1475	DNA binding
A0U89_RS07145	COG2011	ABC-type metal ion transport system permease component
A0U89_RS07150	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A0U89_RS07155	COG1464	Belongs to the NlpA lipoprotein family
A0U89_RS07165	COG0473	3-isopropylmalate dehydrogenase activity
A0U89_RS07170	COG0006	proline dipeptidase activity
A0U89_RS07180	COG2264	protein methyltransferase activity
A0U89_RS07185	COG0210	DNA helicase
A0U89_RS07200	COG2003	Belongs to the UPF0758 family
A0U89_RS07205	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A0U89_RS07225	COG0071	Belongs to the small heat shock protein (HSP20) family
A0U89_RS07230	COG0254	rRNA binding
A0U89_RS07235	COG1970	mechanosensitive ion channel activity
A0U89_RS07250	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A0U89_RS07260	COG0488	(ABC) transporter
A0U89_RS07265	COG0784	Response regulator, receiver
A0U89_RS07290	COG4988	ABC transporter
A0U89_RS07295	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A0U89_RS07305	COG0514	ATP-dependent DNA helicase (RecQ)
A0U89_RS07315	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A0U89_RS07320	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A0U89_RS07325	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A0U89_RS07340	COG0837	glucose binding
A0U89_RS07360	COG0525	valine-tRNA ligase activity
A0U89_RS07365	COG0129	dihydroxy-acid dehydratase activity
A0U89_RS07375	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A0U89_RS07390	COG1174	glycine betaine transport
A0U89_RS07395	COG0756	dUTP diphosphatase activity
A0U89_RS07405	COG2226	methyltransferase
A0U89_RS07410	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A0U89_RS07415	COG0268	Binds directly to 16S ribosomal RNA
A0U89_RS07420	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A0U89_RS07430	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A0U89_RS07445	COG0546	phosphoglycolate phosphatase activity
A0U89_RS07450	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A0U89_RS07455	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A0U89_RS07470	COG2022	thiamine diphosphate biosynthetic process
A0U89_RS07495	COG2719	SpoVR family
A0U89_RS07500	COG2718	Belongs to the UPF0229 family
A0U89_RS07505	COG2766	serine protein kinase
A0U89_RS07510	COG0321	lipoyl(octanoyl) transferase activity
A0U89_RS07510	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A0U89_RS07515	COG0084	hydrolase, TatD family'
A0U89_RS07520	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A0U89_RS07530	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A0U89_RS07535	COG1686	Belongs to the peptidase S11 family
A0U89_RS07545	COG2951	lytic endotransglycosylase activity
A0U89_RS07570	COG1968	undecaprenyl-diphosphatase activity
A0U89_RS07575	COG0531	amino acid
A0U89_RS07600	COG2890	protein-(glutamine-N5) methyltransferase activity
A0U89_RS07610	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A0U89_RS07615	COG0124	histidyl-tRNA synthetase
A0U89_RS07620	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A0U89_RS07630	COG2070	2-Nitropropane dioxygenase
A0U89_RS07640	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A0U89_RS07645	COG2706	6-phosphogluconolactonase activity
A0U89_RS07660	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A0U89_RS07690	COG0321	lipoyl(octanoyl) transferase activity
A0U89_RS07720	COG0076	glutamate decarboxylase activity
A0U89_RS07735	COG1028	Short-chain dehydrogenase reductase Sdr
A0U89_RS07740	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A0U89_RS07745	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A0U89_RS07750	COG5001	Diguanylate cyclase
A0U89_RS07750	COG3300	MHYT domain
A0U89_RS07760	COG1278	Cold shock
A0U89_RS07765	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A0U89_RS07770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A0U89_RS07775	COG0077	Prephenate dehydratase
A0U89_RS07790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A0U89_RS07800	COG0626	cystathionine gamma-synthase activity
A0U89_RS07805	COG2897	thiosulfate sulfurtransferase activity
A0U89_RS07810	COG0628	permease
A0U89_RS07820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A0U89_RS07825	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
A0U89_RS07830	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A0U89_RS07840	COG1381	Involved in DNA repair and RecF pathway recombination
A0U89_RS07845	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A0U89_RS07850	COG0052	Belongs to the universal ribosomal protein uS2 family
A0U89_RS07860	COG1136	(ABC) transporter
A0U89_RS07870	COG0442	prolyl-tRNA aminoacylation
A0U89_RS07880	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A0U89_RS07895	COG0776	regulation of translation
A0U89_RS07905	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A0U89_RS07910	COG0740	serine-type endopeptidase activity
A0U89_RS07915	COG0544	peptidyl-prolyl cis-trans isomerase activity
A0U89_RS07925	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A0U89_RS07925	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A0U89_RS07935	COG0513	Belongs to the DEAD box helicase family
A0U89_RS07945	COG0316	Belongs to the HesB IscA family
A0U89_RS07950	COG2151	metal-sulfur cluster biosynthetic enzyme
A0U89_RS07960	COG0719	Fe-S assembly protein
A0U89_RS07965	COG0396	ATPase activity
A0U89_RS07970	COG0719	Fe-S assembly protein
A0U89_RS07980	COG2733	membrane
A0U89_RS07995	COG2261	transglycosylase associated protein
A0U89_RS08000	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A0U89_RS08005	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A0U89_RS08015	COG5265	(ABC) transporter
A0U89_RS08030	COG0628	permease
A0U89_RS08045	COG0776	regulation of translation
A0U89_RS08050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A0U89_RS08055	COG0416	fatty acid biosynthetic process
A0U89_RS08060	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A0U89_RS08070	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A0U89_RS08080	COG0745	RESPONSE REGULATOR receiver
A0U89_RS08090	COG0242	peptide deformylase activity
A0U89_RS08095	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A0U89_RS08100	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A0U89_RS08120	COG1522	sequence-specific DNA binding
A0U89_RS08125	COG0492	ferredoxin-NADP+ reductase activity
A0U89_RS08130	COG0583	DNA-binding transcription factor activity
A0U89_RS08135	COG0776	regulation of translation
A0U89_RS08140	COG0616	signal peptide processing
A0U89_RS08145	COG4957	zinc ion binding
A0U89_RS08155	COG1289	transmembrane transporter activity
A0U89_RS08175	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A0U89_RS08180	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A0U89_RS08185	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A0U89_RS08190	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A0U89_RS08200	COG3750	Belongs to the UPF0335 family
A0U89_RS08205	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A0U89_RS08215	COG0657	acetylesterase activity
A0U89_RS08225	COG2001	Belongs to the MraZ family
A0U89_RS08230	COG0275	rRNA processing
A0U89_RS08245	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A0U89_RS08250	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A0U89_RS08255	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A0U89_RS08260	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A0U89_RS08270	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A0U89_RS08275	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A0U89_RS08280	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A0U89_RS08285	COG1181	Belongs to the D-alanine--D-alanine ligase family
A0U89_RS08310	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A0U89_RS08315	COG0497	DNA recombination
A0U89_RS08320	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A0U89_RS08325	COG1253	flavin adenine dinucleotide binding
A0U89_RS08330	COG1289	transmembrane transporter activity
A0U89_RS08340	COG1566	PFAM secretion protein HlyD family protein
A0U89_RS08345	COG1335	isochorismatase
A0U89_RS08370	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
A0U89_RS08375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A0U89_RS08395	COG0328	RNA-DNA hybrid ribonuclease activity
A0U89_RS08400	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A0U89_RS08405	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A0U89_RS08420	COG1297	OPT oligopeptide transporter protein
A0U89_RS08435	COG3265	gluconokinase activity
A0U89_RS08465	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A0U89_RS08475	COG0436	Aminotransferase
A0U89_RS08485	COG0473	3-isopropylmalate dehydrogenase activity
A0U89_RS08490	COG0066	3-isopropylmalate dehydratase activity
A0U89_RS08495	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A0U89_RS08500	COG0335	large ribosomal subunit rRNA binding
A0U89_RS08505	COG0336	Belongs to the RNA methyltransferase TrmD family
A0U89_RS08510	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A0U89_RS08515	COG0228	four-way junction DNA binding
A0U89_RS08520	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A0U89_RS08550	COG0306	phosphate transporter
A0U89_RS08570	COG2376	Dihydroxyacetone kinase
A0U89_RS08575	COG1172	Belongs to the binding-protein-dependent transport system permease family
A0U89_RS08580	COG1129	ABC transporter
A0U89_RS08595	COG1349	DNA-binding transcription factor activity
A0U89_RS08610	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A0U89_RS08620	COG1349	DNA-binding transcription factor activity
A0U89_RS08635	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
A0U89_RS08655	COG3386	PFAM SMP-30 Gluconolaconase
A0U89_RS08660	COG1879	ABC-type sugar transport system periplasmic component
A0U89_RS08665	COG1129	ABC transporter
A0U89_RS08670	COG1172	Belongs to the binding-protein-dependent transport system permease family
A0U89_RS08675	COG1172	Belongs to the binding-protein-dependent transport system permease family
A0U89_RS08680	COG2084	Dehydrogenase
A0U89_RS08685	COG1289	transmembrane transporter activity
A0U89_RS08690	COG1250	3-hydroxyacyl-CoA dehydrogenase
A0U89_RS08705	COG0246	Mannitol dehydrogenase
A0U89_RS08760	COG0243	molybdopterin cofactor binding
A0U89_RS08765	COG0746	molybdenum cofactor guanylyltransferase activity
A0U89_RS08765	COG0315	cyclic pyranopterin monophosphate synthase activity
A0U89_RS08805	COG2814	Major facilitator Superfamily
A0U89_RS08810	COG0583	DNA-binding transcription factor activity
A0U89_RS08855	COG0318	PFAM AMP-dependent synthetase and ligase
A0U89_RS08865	COG0156	8-amino-7-oxononanoate synthase activity
A0U89_RS08920	COG0483	inositol monophosphate 1-phosphatase activity
A0U89_RS08930	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A0U89_RS08935	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A0U89_RS08940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A0U89_RS08975	COG3920	Histidine kinase
A0U89_RS08980	COG3590	peptidase
A0U89_RS08995	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A0U89_RS09005	COG1733	regulation of RNA biosynthetic process
A0U89_RS09055	COG1914	H( )-stimulated, divalent metal cation uptake system
A0U89_RS09065	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A0U89_RS09070	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A0U89_RS09075	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A0U89_RS09075	COG0072	phenylalanine-tRNA ligase activity
A0U89_RS09080	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A0U89_RS09085	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A0U89_RS09090	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A0U89_RS09095	COG4993	Dehydrogenase
A0U89_RS09105	COG2166	iron-sulfur cluster assembly
A0U89_RS09110	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A0U89_RS09115	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A0U89_RS09125	COG4191	Histidine kinase
A0U89_RS09125	COG0784	Response regulator, receiver
A0U89_RS09140	COG2884	Cell division ATP-binding protein ftsE
A0U89_RS09165	COG1271	oxidase subunit
A0U89_RS09170	COG1294	oxidase, subunit
A0U89_RS09175	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A0U89_RS09180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A0U89_RS09190	COG0688	phosphatidylethanolamine metabolic process
A0U89_RS09195	COG1183	phosphatidylcholine synthase activity
A0U89_RS09205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A0U89_RS09220	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A0U89_RS09260	COG0277	FAD linked oxidase domain protein
A0U89_RS09265	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A0U89_RS09270	COG0805	protein transport
A0U89_RS09275	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A0U89_RS09280	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A0U89_RS09285	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A0U89_RS09295	COG0018	arginyl-trna synthetase
A0U89_RS09300	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A0U89_RS09310	COG0708	Exodeoxyribonuclease III
A0U89_RS09325	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A0U89_RS09340	COG0752	glycyl-tRNA synthetase alpha subunit
A0U89_RS09355	COG0772	Belongs to the SEDS family
A0U89_RS09360	COG0768	penicillin binding
A0U89_RS09390	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A0U89_RS09395	COG0860	N-Acetylmuramoyl-L-alanine amidase
A0U89_RS09405	COG1530	ribonuclease E activity
A0U89_RS09415	COG1570	exodeoxyribonuclease VII activity
A0U89_RS09430	COG0667	Aldo Keto reductase
A0U89_RS09450	COG4166	transmembrane transport
A0U89_RS09460	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A0U89_RS09460	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A0U89_RS09465	COG2267	carboxylic ester hydrolase activity
A0U89_RS09475	COG3158	transport of potassium into the cell
A0U89_RS09490	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
A0U89_RS09495	COG0246	Mannitol dehydrogenase
A0U89_RS09515	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A0U89_RS09530	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A0U89_RS09545	COG1218	3'(2'),5'-bisphosphate nucleotidase
A0U89_RS09550	COG0009	L-threonylcarbamoyladenylate synthase
A0U89_RS09560	COG0277	FAD linked oxidase domain protein
A0U89_RS09570	COG0612	Peptidase, M16
A0U89_RS09580	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A0U89_RS09585	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A0U89_RS09595	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A0U89_RS09605	COG0793	Belongs to the peptidase S41A family
A0U89_RS09615	COG0494	nUDIX hydrolase
A0U89_RS09620	COG1132	(ABC) transporter
A0U89_RS09625	COG0617	tRNA 3'-terminal CCA addition
A0U89_RS09635	COG0714	Associated with various cellular activities
A0U89_RS09665	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A0U89_RS09680	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A0U89_RS09685	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A0U89_RS09700	COG2814	Major facilitator Superfamily
A0U89_RS09705	COG0203	ribosomal protein L17
A0U89_RS09710	COG0202	RNA polymerase activity
A0U89_RS09715	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A0U89_RS09720	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A0U89_RS09725	COG0563	adenylate kinase activity
A0U89_RS09730	COG0201	protein transport
A0U89_RS09735	COG0200	Binds to the 23S rRNA
A0U89_RS09740	COG1841	ribosomal large subunit assembly
A0U89_RS09745	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A0U89_RS09750	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A0U89_RS09755	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A0U89_RS09760	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A0U89_RS09765	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A0U89_RS09770	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A0U89_RS09775	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A0U89_RS09780	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A0U89_RS09785	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A0U89_RS09790	COG0255	Belongs to the universal ribosomal protein uL29 family
A0U89_RS09795	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A0U89_RS09800	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A0U89_RS09805	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A0U89_RS09810	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A0U89_RS09815	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A0U89_RS09820	COG0089	rRNA binding
A0U89_RS09825	COG0088	Forms part of the polypeptide exit tunnel
A0U89_RS09830	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A0U89_RS09835	COG0051	transcription antitermination factor activity, RNA binding
A0U89_RS09840	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A0U89_RS09845	COG0049	tRNA binding
A0U89_RS09850	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A0U89_RS09855	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A0U89_RS09860	COG0085	RNA polymerase activity
A0U89_RS09865	COG0222	ribosome binding
A0U89_RS09870	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A0U89_RS09875	COG0081	regulation of translation
A0U89_RS09880	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A0U89_RS09890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A0U89_RS09900	COG2205	protein histidine kinase activity
A0U89_RS09920	COG0693	protein deglycase activity
A0U89_RS09925	COG2081	HI0933 family
A0U89_RS09935	COG0850	regulation of cytokinetic process
A0U89_RS09940	COG2894	cell division
A0U89_RS09945	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
A0U89_RS09960	COG4608	Belongs to the ABC transporter superfamily
A0U89_RS09965	COG0444	Belongs to the ABC transporter superfamily
A0U89_RS09975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A0U89_RS09980	COG1028	Short-chain dehydrogenase reductase Sdr
A0U89_RS09995	COG0495	leucyl-tRNA aminoacylation
A0U89_RS10015	COG0679	Auxin Efflux Carrier
A0U89_RS10020	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A0U89_RS10025	COG3001	Fructosamine kinase
A0U89_RS10070	COG1301	dicarboxylic acid transport
A0U89_RS10075	COG1505	serine-type exopeptidase activity
A0U89_RS10080	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A0U89_RS10095	COG0745	RESPONSE REGULATOR receiver
A0U89_RS10105	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A0U89_RS10115	COG0573	inorganic phosphate transmembrane transporter activity
A0U89_RS10135	COG2814	Major facilitator Superfamily
A0U89_RS10145	COG0783	Belongs to the Dps family
A0U89_RS10150	COG0667	Aldo Keto reductase
A0U89_RS10195	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
A0U89_RS10210	COG3180	Ammonia monooxygenase
A0U89_RS10240	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A0U89_RS10245	COG0343	queuine tRNA-ribosyltransferase activity
A0U89_RS10250	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A0U89_RS10265	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A0U89_RS10270	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A0U89_RS10290	COG2853	Lipoprotein
A0U89_RS10310	COG0488	(ABC) transporter
A0U89_RS10320	COG1289	transmembrane transporter activity
A0U89_RS10335	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A0U89_RS10380	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A0U89_RS10380	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A0U89_RS10395	COG1902	pentaerythritol trinitrate reductase activity
A0U89_RS10400	COG0640	Transcriptional regulator
A0U89_RS10415	COG0564	pseudouridine synthase activity
A0U89_RS10435	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A0U89_RS10440	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A0U89_RS10465	COG1113	amino acid transport
A0U89_RS10475	COG3956	TIGRFAM MazG family protein
A0U89_RS10480	COG1760	l-serine dehydratase
A0U89_RS10495	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
A0U89_RS10510	COG4702	Belongs to the UPF0303 family
A0U89_RS10515	COG0673	inositol 2-dehydrogenase activity
A0U89_RS10525	COG2375	cellular response to nickel ion
A0U89_RS10545	COG1028	Short-chain dehydrogenase reductase Sdr
A0U89_RS10550	COG0583	DNA-binding transcription factor activity
A0U89_RS10555	COG3239	Fatty acid desaturase
A0U89_RS10570	COG3025	triphosphatase activity
A0U89_RS10650	COG1566	PFAM secretion protein HlyD family protein
A0U89_RS10675	COG3842	ATPase activity
A0U89_RS10690	COG2983	Belongs to the UPF0260 family
A0U89_RS10710	COG4221	oxidoreductase activity
A0U89_RS10725	COG1215	transferase activity, transferring glycosyl groups
A0U89_RS10730	COG0438	transferase activity, transferring glycosyl groups
A0U89_RS10765	COG0602	queuosine metabolic process
A0U89_RS10770	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A0U89_RS10795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A0U89_RS10800	COG1028	Short-chain dehydrogenase reductase Sdr
A0U89_RS10825	COG0302	gtp cyclohydrolase
A0U89_RS10830	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A0U89_RS10830	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A0U89_RS10835	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A0U89_RS10845	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A0U89_RS10850	COG3706	GGDEF domain
A0U89_RS10855	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A0U89_RS10860	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A0U89_RS10885	COG1028	Short-chain dehydrogenase reductase Sdr
A0U89_RS10890	COG0659	secondary active sulfate transmembrane transporter activity
A0U89_RS10895	COG1959	2 iron, 2 sulfur cluster binding
A0U89_RS10910	COG0483	inositol monophosphate 1-phosphatase activity
A0U89_RS10915	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A0U89_RS10925	COG2204	response regulator
A0U89_RS10935	COG2204	response regulator
A0U89_RS10945	COG3961	Belongs to the TPP enzyme family
A0U89_RS10955	COG0668	transmembrane transport
A0U89_RS10965	COG0300	oxidoreductase activity
A0U89_RS10985	COG0667	Aldo Keto reductase
A0U89_RS11010	COG0156	8-amino-7-oxononanoate synthase activity
A0U89_RS11020	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A0U89_RS11020	COG4106	trans-aconitate 2-methyltransferase activity
A0U89_RS11025	COG4221	oxidoreductase activity
A0U89_RS11035	COG0438	transferase activity, transferring glycosyl groups
A0U89_RS11040	COG1051	belongs to the nudix hydrolase family
A0U89_RS11050	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A0U89_RS11090	COG1238	metal cluster binding
A0U89_RS11105	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A0U89_RS11115	COG1573	uracil-dna glycosylase
A0U89_RS11120	COG0741	lytic transglycosylase activity
A0U89_RS11125	COG1253	flavin adenine dinucleotide binding
A0U89_RS11130	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A0U89_RS11145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A0U89_RS11150	COG3394	polysaccharide catabolic process
A0U89_RS11170	COG1074	ATP-dependent DNA helicase activity
A0U89_RS11175	COG2887	Belongs to the helicase family. UvrD subfamily
A0U89_RS11180	COG0802	atpase or kinase
A0U89_RS11200	COG0384	phenazine biosynthesis protein PhzF
A0U89_RS11205	COG0438	transferase activity, transferring glycosyl groups
A0U89_RS11210	COG0492	ferredoxin-NADP+ reductase activity
A0U89_RS11215	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A0U89_RS11220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A0U89_RS11230	COG1217	gtp-binding protein TYPA
A0U89_RS11235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A0U89_RS11255	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A0U89_RS11260	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A0U89_RS11265	COG2746	aminoglycoside 3-N-acetyltransferase activity
A0U89_RS11270	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A0U89_RS11275	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A0U89_RS11280	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A0U89_RS11285	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A0U89_RS11290	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A0U89_RS11325	COG3008	intermembrane lipid transfer
A0U89_RS11330	COG2995	paraquat-inducible protein a
A0U89_RS11340	COG0531	amino acid
A0U89_RS11370	COG1937	Protein conserved in bacteria
A0U89_RS11390	COG2835	tetraacyldisaccharide 4'-kinase activity
A0U89_RS11405	COG1396	sequence-specific DNA binding
A0U89_RS11410	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A0U89_RS11425	COG4957	zinc ion binding
A0U89_RS11430	COG0456	acetyltransferase
A0U89_RS11440	COG0778	Nitroreductase
A0U89_RS11490	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A0U89_RS11495	COG0667	Aldo Keto reductase
A0U89_RS11515	COG1420	regulation of RNA biosynthetic process
A0U89_RS11520	COG3217	Mosc domain protein beta barrel domain protein
A0U89_RS11520	COG0633	Ferredoxin
A0U89_RS11525	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A0U89_RS11530	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A0U89_RS11540	COG1280	lysine exporter protein (LysE YggA)
A0U89_RS11550	COG5265	(ABC) transporter
A0U89_RS11555	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A0U89_RS11565	COG0658	competence protein
A0U89_RS11565	COG2333	competence protein COMEC
A0U89_RS11590	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A0U89_RS11595	COG0540	Belongs to the ATCase OTCase family
A0U89_RS11600	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A0U89_RS11605	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A0U89_RS11610	COG0758	DNA mediated transformation
A0U89_RS11615	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A0U89_RS11620	COG0793	Belongs to the peptidase S41A family
A0U89_RS11630	COG2885	chlorophyll binding
A0U89_RS11630	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A0U89_RS11640	COG1959	2 iron, 2 sulfur cluster binding
A0U89_RS11655	COG0187	DNA topoisomerase II activity
A0U89_RS11675	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A0U89_RS11685	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A0U89_RS11690	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A0U89_RS11700	COG0196	riboflavin kinase activity
A0U89_RS11705	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
A0U89_RS11710	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
A0U89_RS11715	COG0235	Class ii aldolase
A0U89_RS11720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A0U89_RS11730	COG2137	regulation of response to DNA damage stimulus
A0U89_RS11735	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A0U89_RS11740	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A0U89_RS11745	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A0U89_RS11750	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A0U89_RS11935	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A0U89_RS11940	COG0629	single-stranded DNA binding
A0U89_RS11945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A0U89_RS11950	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A0U89_RS11960	COG1643	Atp-dependent helicase
A0U89_RS11970	COG0745	RESPONSE REGULATOR receiver
A0U89_RS11975	COG5002	protein histidine kinase activity
A0U89_RS11995	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A0U89_RS12000	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A0U89_RS12005	COG0859	PFAM glycosyl transferase family 9
A0U89_RS12010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A0U89_RS12035	COG4993	Dehydrogenase
A0U89_RS12045	COG0438	transferase activity, transferring glycosyl groups
A0U89_RS12060	COG0717	Belongs to the dCTP deaminase family
A0U89_RS12065	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A0U89_RS12075	COG0306	phosphate transporter
A0U89_RS12090	COG1620	l-lactate permease
A0U89_RS12120	COG3547	Transposase (IS116 IS110 IS902 family)
A0U89_RS12130	COG0583	DNA-binding transcription factor activity
A0U89_RS12135	COG1741	Belongs to the pirin family
A0U89_RS12150	COG2259	Doxx family
A0U89_RS12180	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A0U89_RS12200	COG3547	Transposase (IS116 IS110 IS902 family)
A0U89_RS12315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A0U89_RS12330	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A0U89_RS12335	COG0799	negative regulation of ribosome biogenesis
A0U89_RS12340	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A0U89_RS12345	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A0U89_RS12350	COG1929	Belongs to the glycerate kinase type-1 family
A0U89_RS12355	COG0012	GTP binding
A0U89_RS12360	COG0193	aminoacyl-tRNA hydrolase activity
A0U89_RS12365	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A0U89_RS12370	COG0406	alpha-ribazole phosphatase activity
A0U89_RS12375	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A0U89_RS12390	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A0U89_RS12430	COG3754	Rhamnan synthesis protein F
A0U89_RS12445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A0U89_RS12460	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
A0U89_RS12465	COG1877	trehalose-phosphatase activity
A0U89_RS12485	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A0U89_RS12500	COG4786	Flagellar basal body rod
A0U89_RS12505	COG4786	Flagellar basal body rod
A0U89_RS12515	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
A0U89_RS12540	COG0415	Belongs to the DNA photolyase family
A0U89_RS12550	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A0U89_RS12550	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A0U89_RS12560	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A0U89_RS12560	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A0U89_RS12565	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A0U89_RS12595	COG0793	Belongs to the peptidase S41A family
A0U89_RS12595	COG4946	Tricorn protease homolog
A0U89_RS12610	COG1054	Belongs to the UPF0176 family
A0U89_RS12625	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A0U89_RS12655	COG1621	beta-fructofuranosidase activity
A0U89_RS12665	COG1522	sequence-specific DNA binding
A0U89_RS12675	COG3128	pkhd-type hydroxylase
A0U89_RS12715	COG0762	integral membrane protein
A0U89_RS12725	COG4948	Mandelate Racemase Muconate Lactonizing
A0U89_RS12730	COG0800	Aldolase
A0U89_RS12735	COG3734	2-keto-3-deoxy-galactonokinase
A0U89_RS12740	COG1414	Transcriptional regulator
A0U89_RS12750	COG0477	Major facilitator Superfamily
A0U89_RS12760	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A0U89_RS12770	COG0312	modulator of DNA gyrase
A0U89_RS12775	COG2223	nitrite transmembrane transporter activity
A0U89_RS12795	COG1733	regulation of RNA biosynthetic process
A0U89_RS12800	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A0U89_RS12820	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A0U89_RS12835	COG2814	Major facilitator Superfamily
A0U89_RS12845	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A0U89_RS12855	COG1304	FMN binding
A0U89_RS12860	COG2186	Transcriptional regulator
A0U89_RS12890	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A0U89_RS12895	COG0463	Glycosyl transferase, family 2
A0U89_RS12900	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A0U89_RS12905	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A0U89_RS12910	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A0U89_RS12915	COG0356	it plays a direct role in the translocation of protons across the membrane
A0U89_RS12930	COG0596	Alpha beta hydrolase
A0U89_RS12935	COG2353	YceI-like domain
A0U89_RS12940	COG3384	dioxygenase
A0U89_RS12945	COG0583	DNA-binding transcription factor activity
A0U89_RS12955	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A0U89_RS12965	COG4191	Histidine kinase
A0U89_RS12965	COG0784	Response regulator, receiver
A0U89_RS12970	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A0U89_RS12970	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A0U89_RS12975	COG0509	glycine decarboxylation via glycine cleavage system
A0U89_RS12980	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A0U89_RS13005	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A0U89_RS13010	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
A0U89_RS13025	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A0U89_RS13030	COG0440	acetolactate synthase activity
A0U89_RS13035	COG0028	Belongs to the TPP enzyme family
A0U89_RS13040	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A0U89_RS13045	COG0560	Phosphoserine phosphatase
A0U89_RS13045	COG3830	Belongs to the UPF0237 family
A0U89_RS13055	COG0191	fructose-bisphosphate aldolase activity
A0U89_RS13060	COG1309	transcriptional regulator
A0U89_RS13070	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A0U89_RS13100	COG1660	Displays ATPase and GTPase activities
A0U89_RS13105	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A0U89_RS13105	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A0U89_RS13110	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A0U89_RS13125	COG0424	maF-like protein
A0U89_RS13130	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A0U89_RS13135	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A0U89_RS13140	COG1981	membrane
A0U89_RS13150	COG1028	Short-chain dehydrogenase reductase Sdr
A0U89_RS13165	COG0534	Mate efflux family protein
A0U89_RS13170	COG1749	Flagellar hook protein flgE
A0U89_RS13185	COG0535	radical SAM domain protein
A0U89_RS13195	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
A0U89_RS13200	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A0U89_RS13235	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A0U89_RS13260	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A0U89_RS13265	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A0U89_RS13270	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A0U89_RS13275	COG0484	heat shock protein binding
A0U89_RS13280	COG0443	Heat shock 70 kDa protein
A0U89_RS13285	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A0U89_RS13290	COG0745	RESPONSE REGULATOR receiver
A0U89_RS13295	COG2205	protein histidine kinase activity
A0U89_RS13305	COG2814	Major facilitator Superfamily
A0U89_RS13310	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A0U89_RS13340	COG2814	Major facilitator Superfamily
A0U89_RS13345	COG2116	formate transmembrane transporter activity
A0U89_RS13350	COG0285	dihydrofolate synthase activity
A0U89_RS13355	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A0U89_RS13365	COG1012	belongs to the aldehyde dehydrogenase family
A0U89_RS13370	COG0489	protein tyrosine kinase activity
A0U89_RS13390	COG0246	Mannitol dehydrogenase
A0U89_RS13395	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
A0U89_RS13400	COG2943	transferase activity, transferring hexosyl groups
A0U89_RS13405	COG3189	MarR family transcriptional regulator
A0U89_RS13425	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A0U89_RS13445	COG4974	Belongs to the 'phage' integrase family
A0U89_RS13460	COG0004	ammonium transporteR
A0U89_RS13465	COG0347	Belongs to the P(II) protein family
A0U89_RS13470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A0U89_RS13485	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A0U89_RS13535	COG3547	Transposase (IS116 IS110 IS902 family)
A0U89_RS13555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A0U89_RS13565	COG3386	PFAM SMP-30 Gluconolaconase
A0U89_RS13580	COG0159	tryptophan synthase activity
A0U89_RS13585	COG0133	tryptophan synthase activity
A0U89_RS13600	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A0U89_RS13605	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A0U89_RS13610	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A0U89_RS13615	COG0445	tRNA wobble uridine modification
A0U89_RS13620	COG0357	Ribosomal RNA small subunit methyltransferase G
A0U89_RS13670	COG1674	ftsk spoiiie
A0U89_RS14625	COG2814	Major facilitator Superfamily
A0U89_RS14690	COG1034	ATP synthesis coupled electron transport
A0U89_RS14715	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A0U89_RS14755	COG1129	ABC transporter
A0U89_RS14765	COG1129	ABC transporter
A0U89_RS14795	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A0U89_RS15075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A0U89_RS15140	COG1879	ABC-type sugar transport system periplasmic component
A0U89_RS15230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A0U89_RS15570	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A0U89_RS15585	COG1091	dTDP-4-dehydrorhamnose reductase activity
A0U89_RS15695	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A0U89_RS16225	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A0U89_RS16355	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
A0U89_RS16450	COG0366	Alpha amylase catalytic
A0U89_RS16645	COG1091	dTDP-4-dehydrorhamnose reductase activity
A0U89_RS16670	COG1674	ftsk spoiiie
A0U89_RS16750	COG1621	beta-fructofuranosidase activity