locus-tag	class	description
EPA93_RS00095	COG2226	methyltransferase
EPA93_RS00145	COG1695	Transcriptional regulator
EPA93_RS00150	COG1309	transcriptional regulator
EPA93_RS00160	COG0477	Major facilitator Superfamily
EPA93_RS00165	COG5002	protein histidine kinase activity
EPA93_RS00195	COG0842	Transport permease protein
EPA93_RS00200	COG1131	(ABC) transporter
EPA93_RS00205	COG1846	Transcriptional regulator
EPA93_RS00210	COG0384	phenazine biosynthesis protein PhzF
EPA93_RS00255	COG2723	6-phospho-beta-galactosidase activity
EPA93_RS00265	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS00270	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EPA93_RS00280	COG0395	ABC-type sugar transport system, permease component
EPA93_RS00285	COG1175	transmembrane transport
EPA93_RS00290	COG2182	Extracellular solute-binding protein
EPA93_RS00295	COG1609	Transcriptional regulator
EPA93_RS00300	COG4651	solute:proton antiporter activity
EPA93_RS00300	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EPA93_RS00355	COG3246	L-lysine catabolic process to acetate
EPA93_RS00365	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EPA93_RS00385	COG0519	Catalyzes the synthesis of GMP from XMP
EPA93_RS00390	COG1247	-acetyltransferase
EPA93_RS00395	COG0646	methionine synthase
EPA93_RS00395	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EPA93_RS00405	COG0431	NADPH-dependent FMN reductase
EPA93_RS00420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EPA93_RS00430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS00445	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EPA93_RS00445	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EPA93_RS00450	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
EPA93_RS00490	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EPA93_RS00495	COG2226	methyltransferase
EPA93_RS00520	COG0747	negative chemotaxis
EPA93_RS00525	COG1012	belongs to the aldehyde dehydrogenase family
EPA93_RS00530	COG0460	homoserine dehydrogenase
EPA93_RS00535	COG0626	cystathionine gamma-synthase activity
EPA93_RS00540	COG2508	Transcriptional regulator
EPA93_RS00590	COG2197	response regulator
EPA93_RS00595	COG3193	protein, possibly involved in utilization of glycolate and propanediol
EPA93_RS00605	COG4977	sequence-specific DNA binding
EPA93_RS00620	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EPA93_RS00625	COG1522	sequence-specific DNA binding
EPA93_RS00630	COG0242	peptide deformylase activity
EPA93_RS00640	COG0436	Aminotransferase
EPA93_RS00645	COG0436	Aminotransferase
EPA93_RS00650	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS00680	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EPA93_RS00690	COG5002	protein histidine kinase activity
EPA93_RS00705	COG1686	Belongs to the peptidase S11 family
EPA93_RS00710	COG0768	penicillin binding
EPA93_RS00730	COG1051	belongs to the nudix hydrolase family
EPA93_RS00740	COG0006	proline dipeptidase activity
EPA93_RS00750	COG0395	ABC-type sugar transport system, permease component
EPA93_RS00765	COG1609	Transcriptional regulator
EPA93_RS00780	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS00790	COG0803	Belongs to the bacterial solute-binding protein 9 family
EPA93_RS00795	COG1121	(ABC) transporter
EPA93_RS00800	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EPA93_RS00835	COG1247	-acetyltransferase
EPA93_RS00860	COG0596	Alpha beta hydrolase
EPA93_RS00875	COG1733	regulation of RNA biosynthetic process
EPA93_RS00885	COG1733	regulation of RNA biosynthetic process
EPA93_RS00895	COG1309	transcriptional regulator
EPA93_RS00920	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EPA93_RS00925	COG1819	glycosyl
EPA93_RS00970	COG4821	SIS domain
EPA93_RS00985	COG2814	Major facilitator Superfamily
EPA93_RS00995	COG2226	methyltransferase
EPA93_RS01015	COG0582	viral genome integration into host DNA
EPA93_RS01030	COG1309	transcriptional regulator
EPA93_RS01050	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EPA93_RS01075	COG0395	ABC-type sugar transport system, permease component
EPA93_RS01085	COG1609	Transcriptional regulator
EPA93_RS01090	COG1486	melibiose metabolic process
EPA93_RS01115	COG1335	isochorismatase
EPA93_RS01135	COG2197	response regulator
EPA93_RS01140	COG4585	Histidine kinase
EPA93_RS01145	COG1136	(ABC) transporter
EPA93_RS01145	COG0577	efflux transmembrane transporter activity
EPA93_RS01150	COG1136	(ABC) transporter
EPA93_RS01180	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EPA93_RS01180	COG4651	solute:proton antiporter activity
EPA93_RS01205	COG0586	Pfam SNARE associated Golgi protein
EPA93_RS01210	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EPA93_RS01215	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EPA93_RS01235	COG2124	cytochrome p450
EPA93_RS01260	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EPA93_RS01265	COG1733	regulation of RNA biosynthetic process
EPA93_RS01270	COG2267	carboxylic ester hydrolase activity
EPA93_RS01275	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EPA93_RS01310	COG2226	methyltransferase
EPA93_RS01330	COG4221	oxidoreductase activity
EPA93_RS01350	COG0531	amino acid
EPA93_RS01355	COG2815	serine threonine protein kinase
EPA93_RS01355	COG0515	serine threonine protein kinase
EPA93_RS01365	COG2815	serine threonine protein kinase
EPA93_RS01365	COG0515	serine threonine protein kinase
EPA93_RS01375	COG4895	conserved protein (DUF2196)
EPA93_RS01390	COG2909	trisaccharide binding
EPA93_RS01400	COG0509	glycine decarboxylation via glycine cleavage system
EPA93_RS01405	COG2217	Heavy metal translocating P-type atpase
EPA93_RS01420	COG0671	phosphoesterase, PA-phosphatase related
EPA93_RS01455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EPA93_RS01455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPA93_RS01460	COG1309	transcriptional regulator
EPA93_RS01465	COG1136	(ABC) transporter
EPA93_RS01465	COG0577	efflux transmembrane transporter activity
EPA93_RS01470	COG1136	(ABC) transporter
EPA93_RS01475	COG1522	sequence-specific DNA binding
EPA93_RS01485	COG2807	transmembrane transport
EPA93_RS01490	COG2186	Transcriptional regulator
EPA93_RS01535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EPA93_RS01540	COG2267	carboxylic ester hydrolase activity
EPA93_RS01555	COG1309	transcriptional regulator
EPA93_RS01610	COG1309	transcriptional regulator
EPA93_RS01640	COG2909	trisaccharide binding
EPA93_RS01660	COG0693	protein deglycase activity
EPA93_RS01665	COG1063	alcohol dehydrogenase
EPA93_RS01670	COG1215	transferase activity, transferring glycosyl groups
EPA93_RS01710	COG2226	methyltransferase
EPA93_RS01710	COG1073	alpha beta
EPA93_RS01725	COG1051	belongs to the nudix hydrolase family
EPA93_RS01735	COG0697	spore germination
EPA93_RS01740	COG3525	Glycosyl hydrolase, family 20, catalytic domain
EPA93_RS01745	COG0825	malonyl-CoA metabolic process
EPA93_RS01765	COG2072	flavoprotein involved in K transport
EPA93_RS01805	COG0747	negative chemotaxis
EPA93_RS01840	COG2271	Major facilitator Superfamily
EPA93_RS01845	COG2226	methyltransferase
EPA93_RS01885	COG2217	Heavy metal translocating P-type atpase
EPA93_RS01935	COG0583	DNA-binding transcription factor activity
EPA93_RS01985	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
EPA93_RS02020	COG2197	response regulator
EPA93_RS02025	COG4585	Histidine kinase
EPA93_RS02080	COG2271	Major facilitator Superfamily
EPA93_RS02085	COG0076	glutamate decarboxylase activity
EPA93_RS02110	COG2124	cytochrome p450
EPA93_RS02130	COG1122	ATPase activity
EPA93_RS02135	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EPA93_RS02165	COG1131	(ABC) transporter
EPA93_RS02185	COG1877	trehalose-phosphatase activity
EPA93_RS02185	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EPA93_RS02200	COG2423	ornithine cyclodeaminase activity
EPA93_RS02210	COG0640	Transcriptional regulator
EPA93_RS02230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPA93_RS02235	COG0156	8-amino-7-oxononanoate synthase activity
EPA93_RS02240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EPA93_RS02275	COG1309	transcriptional regulator
EPA93_RS02285	COG0745	RESPONSE REGULATOR receiver
EPA93_RS02290	COG2132	Multicopper oxidase
EPA93_RS02360	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EPA93_RS02380	COG1131	(ABC) transporter
EPA93_RS02445	COG1846	Transcriptional regulator
EPA93_RS02455	COG1914	H( )-stimulated, divalent metal cation uptake system
EPA93_RS02460	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EPA93_RS02520	COG1595	DNA-templated transcription, initiation
EPA93_RS02525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EPA93_RS02530	COG0577	efflux transmembrane transporter activity
EPA93_RS02535	COG1136	(ABC) transporter
EPA93_RS02550	COG0745	RESPONSE REGULATOR receiver
EPA93_RS02555	COG5002	protein histidine kinase activity
EPA93_RS02570	COG1309	transcriptional regulator
EPA93_RS02595	COG2226	methyltransferase
EPA93_RS02605	COG0477	Major facilitator Superfamily
EPA93_RS02635	COG1733	regulation of RNA biosynthetic process
EPA93_RS02715	COG1476	TRANSCRIPTIONal
EPA93_RS02785	COG5433	transposase activity
EPA93_RS02790	COG0402	S-adenosylhomocysteine deaminase activity
EPA93_RS02795	COG2814	Major facilitator Superfamily
EPA93_RS02825	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS02860	COG0514	ATP-dependent DNA helicase (RecQ)
EPA93_RS02865	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS02885	COG0475	glutathione-regulated potassium exporter activity
EPA93_RS02890	COG1846	Transcriptional regulator
EPA93_RS02905	COG3629	intracellular signal transduction
EPA93_RS02905	COG3903	Transcriptional regulator
EPA93_RS02915	COG1309	transcriptional regulator
EPA93_RS02935	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EPA93_RS02945	COG2226	methyltransferase
EPA93_RS02955	COG1309	transcriptional regulator
EPA93_RS02960	COG3848	Pyruvate phosphate dikinase
EPA93_RS02960	COG0574	Belongs to the PEP-utilizing enzyme family
EPA93_RS02965	COG0596	Alpha beta hydrolase
EPA93_RS02975	COG2124	cytochrome p450
EPA93_RS03050	COG2124	cytochrome p450
EPA93_RS03070	COG3620	sequence-specific DNA binding
EPA93_RS03090	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EPA93_RS03095	COG0641	radical SAM
EPA93_RS03105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS03110	COG0747	negative chemotaxis
EPA93_RS03135	COG0657	acetylesterase activity
EPA93_RS03170	COG0154	amidase activity
EPA93_RS03175	COG2267	carboxylic ester hydrolase activity
EPA93_RS03180	COG1597	lipid kinase activity
EPA93_RS03185	COG1960	acyl-CoA dehydrogenase activity
EPA93_RS03220	COG2267	carboxylic ester hydrolase activity
EPA93_RS03225	COG0076	glutamate decarboxylase activity
EPA93_RS03310	COG2267	carboxylic ester hydrolase activity
EPA93_RS03325	COG0596	Alpha beta hydrolase
EPA93_RS03335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS03420	COG2814	Major facilitator Superfamily
EPA93_RS03445	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EPA93_RS03450	COG0477	Major facilitator Superfamily
EPA93_RS03455	COG1309	transcriptional regulator
EPA93_RS03470	COG1215	transferase activity, transferring glycosyl groups
EPA93_RS03480	COG4585	Histidine kinase
EPA93_RS03485	COG2197	response regulator
EPA93_RS03495	COG3250	beta-galactosidase activity
EPA93_RS03500	COG0395	ABC-type sugar transport system, permease component
EPA93_RS03505	COG1175	transmembrane transport
EPA93_RS03510	COG1653	transport
EPA93_RS03515	COG1609	Transcriptional regulator
EPA93_RS03530	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EPA93_RS03535	COG2909	trisaccharide binding
EPA93_RS03545	COG2272	Belongs to the type-B carboxylesterase lipase family
EPA93_RS03555	COG0745	RESPONSE REGULATOR receiver
EPA93_RS03560	COG2909	trisaccharide binding
EPA93_RS03590	COG1309	transcriptional regulator
EPA93_RS03595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPA93_RS03615	COG1522	sequence-specific DNA binding
EPA93_RS03625	COG0604	alcohol dehydrogenase
EPA93_RS03635	COG0789	Transcriptional regulator
EPA93_RS03640	COG0604	alcohol dehydrogenase
EPA93_RS03645	COG1309	transcriptional regulator
EPA93_RS03650	COG1309	transcriptional regulator
EPA93_RS03660	COG0657	acetylesterase activity
EPA93_RS03675	COG2226	methyltransferase
EPA93_RS03680	COG0657	acetylesterase activity
EPA93_RS03685	COG1175	transmembrane transport
EPA93_RS03690	COG0395	ABC-type sugar transport system, permease component
EPA93_RS03700	COG1132	(ABC) transporter
EPA93_RS03705	COG1132	(ABC) transporter
EPA93_RS03780	COG4644	lycopene metabolic process
EPA93_RS03820	COG3831	ATPase activity
EPA93_RS03865	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EPA93_RS03870	COG0732	type I restriction modification DNA specificity domain
EPA93_RS03875	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EPA93_RS03880	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EPA93_RS03890	COG2135	peptidase activity
EPA93_RS03965	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EPA93_RS04040	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EPA93_RS04050	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS04070	COG0045	succinate-CoA ligase (ADP-forming) activity
EPA93_RS04070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPA93_RS04070	COG1042	CoA-binding domain protein
EPA93_RS04115	COG0156	8-amino-7-oxononanoate synthase activity
EPA93_RS04120	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EPA93_RS04145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS04150	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EPA93_RS04160	COG0667	Aldo Keto reductase
EPA93_RS04215	COG0640	Transcriptional regulator
EPA93_RS04220	COG2746	aminoglycoside 3-N-acetyltransferase activity
EPA93_RS04240	COG1280	lysine exporter protein (LysE YggA)
EPA93_RS04315	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EPA93_RS04325	COG2814	Major facilitator Superfamily
EPA93_RS04350	COG1136	(ABC) transporter
EPA93_RS04355	COG2177	Part of the ABC transporter FtsEX involved in
EPA93_RS04425	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPA93_RS04460	COG1959	2 iron, 2 sulfur cluster binding
EPA93_RS04465	COG2910	NAD(P)H-binding
EPA93_RS04470	COG2076	Multidrug Resistance protein
EPA93_RS04480	COG0789	Transcriptional regulator
EPA93_RS04500	COG0582	viral genome integration into host DNA
EPA93_RS04510	COG1959	2 iron, 2 sulfur cluster binding
EPA93_RS04525	COG2267	carboxylic ester hydrolase activity
EPA93_RS04610	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EPA93_RS04635	COG2815	serine threonine protein kinase
EPA93_RS04635	COG0515	serine threonine protein kinase
EPA93_RS04640	COG5002	protein histidine kinase activity
EPA93_RS04645	COG0784	Response regulator, receiver
EPA93_RS04650	COG4251	negative regulation of phosphorylation
EPA93_RS04655	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EPA93_RS04660	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EPA93_RS04665	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EPA93_RS04695	COG2204	response regulator
EPA93_RS04715	COG4106	trans-aconitate 2-methyltransferase activity
EPA93_RS04720	COG0589	response to stress
EPA93_RS04725	COG0456	acetyltransferase
EPA93_RS04765	COG0477	Major facilitator Superfamily
EPA93_RS04775	COG2814	Major facilitator Superfamily
EPA93_RS04780	COG1309	transcriptional regulator
EPA93_RS04795	COG2197	response regulator
EPA93_RS04815	COG1280	lysine exporter protein (LysE YggA)
EPA93_RS04825	COG0515	serine threonine protein kinase
EPA93_RS04825	COG2815	serine threonine protein kinase
EPA93_RS04830	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EPA93_RS04925	COG2814	Major facilitator Superfamily
EPA93_RS04950	COG1846	Transcriptional regulator
EPA93_RS04955	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EPA93_RS04980	COG1309	transcriptional regulator
EPA93_RS04985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPA93_RS05015	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EPA93_RS05040	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
EPA93_RS05050	COG4585	Histidine kinase
EPA93_RS05060	COG0604	alcohol dehydrogenase
EPA93_RS05065	COG0583	DNA-binding transcription factor activity
EPA93_RS05100	COG0596	Alpha beta hydrolase
EPA93_RS05105	COG0204	Acyl-transferase
EPA93_RS05200	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPA93_RS05210	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EPA93_RS05215	COG0604	alcohol dehydrogenase
EPA93_RS05275	COG2226	methyltransferase
EPA93_RS05280	COG0596	Alpha beta hydrolase
EPA93_RS05285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPA93_RS05290	COG0243	molybdopterin cofactor binding
EPA93_RS05295	COG1309	transcriptional regulator
EPA93_RS05305	COG2252	PERMEase
EPA93_RS05320	COG1846	Transcriptional regulator
EPA93_RS05325	COG0477	Major facilitator Superfamily
EPA93_RS05335	COG0477	Major facilitator Superfamily
EPA93_RS05370	COG1309	transcriptional regulator
EPA93_RS05375	COG0747	negative chemotaxis
EPA93_RS05385	COG2815	serine threonine protein kinase
EPA93_RS05385	COG0515	serine threonine protein kinase
EPA93_RS05390	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EPA93_RS05400	COG1846	Transcriptional regulator
EPA93_RS05420	COG1309	transcriptional regulator
EPA93_RS05425	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS05435	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EPA93_RS05440	COG4946	Tricorn protease homolog
EPA93_RS05440	COG0793	Belongs to the peptidase S41A family
EPA93_RS05445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS05455	COG4978	Transcriptional regulator
EPA93_RS05455	COG0789	Transcriptional regulator
EPA93_RS05465	COG4585	Histidine kinase
EPA93_RS05470	COG2197	response regulator
EPA93_RS05485	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
EPA93_RS05530	COG0681	Belongs to the peptidase S26 family
EPA93_RS05585	COG4166	transmembrane transport
EPA93_RS05605	COG4585	Histidine kinase
EPA93_RS05625	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EPA93_RS05645	COG2124	cytochrome p450
EPA93_RS05650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EPA93_RS05655	COG0640	Transcriptional regulator
EPA93_RS05685	COG0515	serine threonine protein kinase
EPA93_RS05690	COG1349	DNA-binding transcription factor activity
EPA93_RS05695	COG3321	synthase
EPA93_RS05695	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS05695	COG0604	alcohol dehydrogenase
EPA93_RS05710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPA93_RS05730	COG1971	Probably functions as a manganese efflux pump
EPA93_RS05735	COG2226	methyltransferase
EPA93_RS05740	COG4106	trans-aconitate 2-methyltransferase activity
EPA93_RS05750	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
EPA93_RS05760	COG2124	cytochrome p450
EPA93_RS05775	COG0640	Transcriptional regulator
EPA93_RS05780	COG0477	Major facilitator Superfamily
EPA93_RS05795	COG2964	Protein conserved in bacteria
EPA93_RS05800	COG1053	succinate dehydrogenase
EPA93_RS05825	COG0596	Alpha beta hydrolase
EPA93_RS05830	COG0583	DNA-binding transcription factor activity
EPA93_RS05835	COG0477	Major facilitator Superfamily
EPA93_RS05840	COG0583	DNA-binding transcription factor activity
EPA93_RS05860	COG1505	serine-type exopeptidase activity
EPA93_RS05870	COG2226	methyltransferase
EPA93_RS05900	COG1846	Transcriptional regulator
EPA93_RS05940	COG0583	DNA-binding transcription factor activity
EPA93_RS06030	COG2382	esterase
EPA93_RS06065	COG0494	nUDIX hydrolase
EPA93_RS06080	COG2226	methyltransferase
EPA93_RS06095	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EPA93_RS06100	COG4585	Histidine kinase
EPA93_RS06105	COG2197	response regulator
EPA93_RS06120	COG2226	methyltransferase
EPA93_RS06135	COG1486	melibiose metabolic process
EPA93_RS06145	COG1175	transmembrane transport
EPA93_RS06155	COG1609	Transcriptional regulator
EPA93_RS06160	COG1378	Sugar-specific transcriptional regulator TrmB
EPA93_RS06170	COG0697	spore germination
EPA93_RS06205	COG2226	methyltransferase
EPA93_RS06210	COG2226	methyltransferase
EPA93_RS06220	COG0179	Fumarylacetoacetate (FAA) hydrolase
EPA93_RS06230	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
EPA93_RS06275	COG4555	ABC transporter
EPA93_RS06295	COG2909	trisaccharide binding
EPA93_RS06310	COG0667	Aldo Keto reductase
EPA93_RS06325	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EPA93_RS06345	COG2909	trisaccharide binding
EPA93_RS06360	COG1309	transcriptional regulator
EPA93_RS06365	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS06385	COG0494	nUDIX hydrolase
EPA93_RS06405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPA93_RS06430	COG2124	cytochrome p450
EPA93_RS06450	COG1309	transcriptional regulator
EPA93_RS06460	COG2223	nitrite transmembrane transporter activity
EPA93_RS06510	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EPA93_RS06520	COG1609	Transcriptional regulator
EPA93_RS06535	COG1649	PFAM Uncharacterised BCR, COG1649
EPA93_RS06560	COG4978	Transcriptional regulator
EPA93_RS06560	COG0789	Transcriptional regulator
EPA93_RS06605	COG0596	Alpha beta hydrolase
EPA93_RS06620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS06650	COG0154	amidase activity
EPA93_RS06700	COG0515	serine threonine protein kinase
EPA93_RS06700	COG2815	serine threonine protein kinase
EPA93_RS06725	COG3220	belongs to the UPF0276 family
EPA93_RS06730	COG2226	methyltransferase
EPA93_RS06735	COG1131	(ABC) transporter
EPA93_RS06745	COG0367	asparagine synthase
EPA93_RS06750	COG0367	asparagine synthase
EPA93_RS06760	COG0583	DNA-binding transcription factor activity
EPA93_RS06765	COG2814	Major facilitator Superfamily
EPA93_RS06775	COG0456	acetyltransferase
EPA93_RS06780	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
EPA93_RS06800	COG0346	lactoylglutathione lyase activity
EPA93_RS06810	COG0477	Major facilitator Superfamily
EPA93_RS06815	COG0747	negative chemotaxis
EPA93_RS06820	COG2909	trisaccharide binding
EPA93_RS06845	COG0697	spore germination
EPA93_RS06865	COG1846	Transcriptional regulator
EPA93_RS06870	COG2226	methyltransferase
EPA93_RS06880	COG0596	Alpha beta hydrolase
EPA93_RS06895	COG2909	trisaccharide binding
EPA93_RS06900	COG2267	carboxylic ester hydrolase activity
EPA93_RS06920	COG0346	lactoylglutathione lyase activity
EPA93_RS06935	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS06940	COG0640	Transcriptional regulator
EPA93_RS06955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EPA93_RS06975	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EPA93_RS07005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EPA93_RS07065	COG1522	sequence-specific DNA binding
EPA93_RS07085	COG1309	transcriptional regulator
EPA93_RS07095	COG0456	acetyltransferase
EPA93_RS07115	COG0583	DNA-binding transcription factor activity
EPA93_RS07130	COG2124	cytochrome p450
EPA93_RS07140	COG2124	cytochrome p450
EPA93_RS07160	COG0626	cystathionine gamma-synthase activity
EPA93_RS07165	COG0315	cyclic pyranopterin monophosphate synthase activity
EPA93_RS07200	COG2226	methyltransferase
EPA93_RS07200	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EPA93_RS07200	COG0596	Alpha beta hydrolase
EPA93_RS07250	COG0583	DNA-binding transcription factor activity
EPA93_RS07255	COG0477	Major facilitator Superfamily
EPA93_RS07260	COG1846	Transcriptional regulator
EPA93_RS07280	COG1660	Displays ATPase and GTPase activities
EPA93_RS07305	COG0789	Transcriptional regulator
EPA93_RS07310	COG0673	inositol 2-dehydrogenase activity
EPA93_RS07320	COG1175	transmembrane transport
EPA93_RS07325	COG0395	ABC-type sugar transport system, permease component
EPA93_RS07330	COG2188	Transcriptional regulator
EPA93_RS07335	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS07345	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EPA93_RS07385	COG0477	Major facilitator Superfamily
EPA93_RS07415	COG3239	Fatty acid desaturase
EPA93_RS07420	COG4122	O-methyltransferase activity
EPA93_RS07490	COG5002	protein histidine kinase activity
EPA93_RS07515	COG3457	Alanine racemase
EPA93_RS07520	COG0531	amino acid
EPA93_RS07550	COG0477	Major facilitator Superfamily
EPA93_RS07590	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EPA93_RS07610	COG5002	protein histidine kinase activity
EPA93_RS07615	COG0745	RESPONSE REGULATOR receiver
EPA93_RS07640	COG2909	trisaccharide binding
EPA93_RS07665	COG0366	Alpha amylase catalytic
EPA93_RS07690	COG1131	(ABC) transporter
EPA93_RS07700	COG0745	RESPONSE REGULATOR receiver
EPA93_RS07705	COG5002	protein histidine kinase activity
EPA93_RS07705	COG3850	Histidine kinase
EPA93_RS07725	COG1132	(ABC) transporter
EPA93_RS07740	COG1017	nitric oxide dioxygenase activity
EPA93_RS07740	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EPA93_RS07770	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EPA93_RS07835	COG1695	Transcriptional regulator
EPA93_RS07855	COG2801	Transposase and inactivated derivatives
EPA93_RS07860	COG1733	regulation of RNA biosynthetic process
EPA93_RS07870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS07875	COG1846	Transcriptional regulator
EPA93_RS07885	COG0596	Alpha beta hydrolase
EPA93_RS07890	COG2205	protein histidine kinase activity
EPA93_RS07895	COG0745	RESPONSE REGULATOR receiver
EPA93_RS07915	COG0667	Aldo Keto reductase
EPA93_RS07945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS07950	COG1522	sequence-specific DNA binding
EPA93_RS07975	COG2814	Major facilitator Superfamily
EPA93_RS07985	COG0789	Transcriptional regulator
EPA93_RS08015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS08055	COG0596	Alpha beta hydrolase
EPA93_RS08065	COG1595	DNA-templated transcription, initiation
EPA93_RS08105	COG1192	Involved in chromosome partitioning
EPA93_RS08115	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS08135	COG0477	Major facilitator Superfamily
EPA93_RS08155	COG1309	transcriptional regulator
EPA93_RS08165	COG0667	Aldo Keto reductase
EPA93_RS08170	COG0477	Major facilitator Superfamily
EPA93_RS08185	COG4106	trans-aconitate 2-methyltransferase activity
EPA93_RS08205	COG1309	transcriptional regulator
EPA93_RS08210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS08215	COG2226	methyltransferase
EPA93_RS08220	COG1595	DNA-templated transcription, initiation
EPA93_RS08230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EPA93_RS08235	COG0366	Alpha amylase catalytic
EPA93_RS08240	COG1609	Transcriptional regulator
EPA93_RS08245	COG0596	Alpha beta hydrolase
EPA93_RS08250	COG1175	transmembrane transport
EPA93_RS08255	COG0395	ABC-type sugar transport system, permease component
EPA93_RS08260	COG1653	transport
EPA93_RS08280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPA93_RS08295	COG0667	Aldo Keto reductase
EPA93_RS08320	COG1309	transcriptional regulator
EPA93_RS08330	COG1132	(ABC) transporter
EPA93_RS08335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS08365	COG0667	Aldo Keto reductase
EPA93_RS08375	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
EPA93_RS08465	COG1595	DNA-templated transcription, initiation
EPA93_RS08475	COG1132	(ABC) transporter
EPA93_RS08480	COG1132	(ABC) transporter
EPA93_RS08490	COG0504	CTP synthase activity
EPA93_RS08520	COG2124	cytochrome p450
EPA93_RS08525	COG0563	adenylate kinase activity
EPA93_RS08535	COG3832	glyoxalase III activity
EPA93_RS08545	COG3548	integral membrane protein
EPA93_RS08565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EPA93_RS08575	COG1252	NADH dehydrogenase
EPA93_RS08580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPA93_RS08655	COG1695	Transcriptional regulator
EPA93_RS08685	COG2226	methyltransferase
EPA93_RS08690	COG2890	protein-(glutamine-N5) methyltransferase activity
EPA93_RS08695	COG2226	methyltransferase
EPA93_RS08700	COG2226	methyltransferase
EPA93_RS08705	COG2226	methyltransferase
EPA93_RS08710	COG0640	Transcriptional regulator
EPA93_RS08715	COG0183	Belongs to the thiolase family
EPA93_RS08745	COG0702	epimerase
EPA93_RS08760	COG0596	Alpha beta hydrolase
EPA93_RS08765	COG1686	Belongs to the peptidase S11 family
EPA93_RS08770	COG0702	epimerase
EPA93_RS08815	COG0366	Alpha amylase catalytic
EPA93_RS08820	COG4106	trans-aconitate 2-methyltransferase activity
EPA93_RS08830	COG0667	Aldo Keto reductase
EPA93_RS08835	COG2814	Major facilitator Superfamily
EPA93_RS08860	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EPA93_RS08865	COG4166	transmembrane transport
EPA93_RS08885	COG0750	zinc metalloprotease
EPA93_RS08900	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS08905	COG1012	belongs to the aldehyde dehydrogenase family
EPA93_RS08910	COG2188	Transcriptional regulator
EPA93_RS08925	COG1846	Transcriptional regulator
EPA93_RS08935	COG3173	Aminoglycoside phosphotransferase
EPA93_RS08940	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EPA93_RS08985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS08995	COG1522	sequence-specific DNA binding
EPA93_RS09015	COG2755	lipolytic protein G-D-S-L family
EPA93_RS09015	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EPA93_RS09020	COG2267	carboxylic ester hydrolase activity
EPA93_RS09025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS09030	COG4585	Histidine kinase
EPA93_RS09040	COG0477	Major facilitator Superfamily
EPA93_RS09050	COG0583	DNA-binding transcription factor activity
EPA93_RS09065	COG1733	regulation of RNA biosynthetic process
EPA93_RS09075	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EPA93_RS09090	COG1672	PFAM Archaeal ATPase
EPA93_RS09090	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
EPA93_RS09105	COG0583	DNA-binding transcription factor activity
EPA93_RS09120	COG2319	Wd-40 repeat
EPA93_RS09130	COG0531	amino acid
EPA93_RS09150	COG1819	glycosyl
EPA93_RS09160	COG0662	Cupin 2, conserved barrel domain protein
EPA93_RS09165	COG0384	phenazine biosynthesis protein PhzF
EPA93_RS09170	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EPA93_RS09175	COG0596	Alpha beta hydrolase
EPA93_RS09185	COG0583	DNA-binding transcription factor activity
EPA93_RS09285	COG3665	Urea carboxylase-associated protein
EPA93_RS09315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPA93_RS09330	COG0789	Transcriptional regulator
EPA93_RS09380	COG2226	methyltransferase
EPA93_RS09405	COG0583	DNA-binding transcription factor activity
EPA93_RS09430	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EPA93_RS09450	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EPA93_RS09455	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EPA93_RS09460	COG0667	Aldo Keto reductase
EPA93_RS09465	COG1959	2 iron, 2 sulfur cluster binding
EPA93_RS09515	COG1280	lysine exporter protein (LysE YggA)
EPA93_RS09545	COG0747	negative chemotaxis
EPA93_RS09565	COG0789	Transcriptional regulator
EPA93_RS09580	COG2226	methyltransferase
EPA93_RS09615	COG2124	cytochrome p450
EPA93_RS09640	COG0778	Nitroreductase
EPA93_RS09660	COG2255	four-way junction helicase activity
EPA93_RS09675	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EPA93_RS09700	COG1131	(ABC) transporter
EPA93_RS09710	COG2124	cytochrome p450
EPA93_RS09725	COG1285	pathogenesis
EPA93_RS09730	COG2226	methyltransferase
EPA93_RS09735	COG0477	Major facilitator Superfamily
EPA93_RS09770	COG1595	DNA-templated transcription, initiation
EPA93_RS09775	COG0604	alcohol dehydrogenase
EPA93_RS09800	COG2124	cytochrome p450
EPA93_RS09810	COG1846	Transcriptional regulator
EPA93_RS09825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EPA93_RS09885	COG2226	methyltransferase
EPA93_RS09890	COG2818	Glycosylase
EPA93_RS09905	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EPA93_RS09930	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EPA93_RS09935	COG2271	Major facilitator Superfamily
EPA93_RS09960	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EPA93_RS09965	COG1181	Belongs to the D-alanine--D-alanine ligase family
EPA93_RS09990	COG2205	protein histidine kinase activity
EPA93_RS10000	COG1522	sequence-specific DNA binding
EPA93_RS10005	COG4106	trans-aconitate 2-methyltransferase activity
EPA93_RS10035	COG1695	Transcriptional regulator
EPA93_RS10045	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EPA93_RS10075	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EPA93_RS10095	COG5433	transposase activity
EPA93_RS10100	COG1309	transcriptional regulator
EPA93_RS10125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPA93_RS10135	COG1309	transcriptional regulator
EPA93_RS10165	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EPA93_RS10170	COG0412	Dienelactone hydrolase
EPA93_RS10175	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EPA93_RS10220	COG0697	spore germination
EPA93_RS10250	COG1129	ABC transporter
EPA93_RS10255	COG1172	Belongs to the binding-protein-dependent transport system permease family
EPA93_RS10280	COG0745	RESPONSE REGULATOR receiver
EPA93_RS10285	COG0463	Glycosyl transferase, family 2
EPA93_RS10290	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EPA93_RS10300	COG1609	Transcriptional regulator
EPA93_RS10310	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
EPA93_RS10330	COG3627	carbon phosphorus lyase activity
EPA93_RS10335	COG4107	phosphonate C-P lyase system protein PhnK
EPA93_RS10340	COG4778	phosphonate C-P lyase system protein PhnL
EPA93_RS10345	COG3454	Phosphonate metabolism
EPA93_RS10355	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EPA93_RS10380	COG2909	trisaccharide binding
EPA93_RS10405	COG5002	protein histidine kinase activity
EPA93_RS10445	COG1063	alcohol dehydrogenase
EPA93_RS10450	COG0363	glucosamine-6-phosphate deaminase activity
EPA93_RS10460	COG2197	response regulator
EPA93_RS10465	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPA93_RS10475	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EPA93_RS10495	COG4106	trans-aconitate 2-methyltransferase activity
EPA93_RS10500	COG3795	YCII-related domain
EPA93_RS10510	COG4941	Belongs to the sigma-70 factor family
EPA93_RS10575	COG1595	DNA-templated transcription, initiation
EPA93_RS10610	COG0657	acetylesterase activity
EPA93_RS10615	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EPA93_RS10635	COG0477	Major facilitator Superfamily
EPA93_RS10650	COG5002	protein histidine kinase activity
EPA93_RS10655	COG0745	RESPONSE REGULATOR receiver
EPA93_RS10685	COG2271	Major facilitator Superfamily
EPA93_RS10700	COG4405	Protein conserved in bacteria
EPA93_RS10705	COG0346	lactoylglutathione lyase activity
EPA93_RS10715	COG4221	oxidoreductase activity
EPA93_RS10780	COG0531	amino acid
EPA93_RS10785	COG3250	beta-galactosidase activity
EPA93_RS10790	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS10795	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EPA93_RS10800	COG1486	melibiose metabolic process
EPA93_RS10805	COG2186	Transcriptional regulator
EPA93_RS10810	COG1653	transport
EPA93_RS10815	COG1175	transmembrane transport
EPA93_RS10825	COG0129	dihydroxy-acid dehydratase activity
EPA93_RS10850	COG3848	Pyruvate phosphate dikinase
EPA93_RS10850	COG0574	Belongs to the PEP-utilizing enzyme family
EPA93_RS10870	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EPA93_RS10895	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EPA93_RS10915	COG2186	Transcriptional regulator
EPA93_RS10925	COG0515	serine threonine protein kinase
EPA93_RS10925	COG2815	serine threonine protein kinase
EPA93_RS10930	COG2815	serine threonine protein kinase
EPA93_RS10930	COG0515	serine threonine protein kinase
EPA93_RS10935	COG0488	(ABC) transporter
EPA93_RS10950	COG1012	belongs to the aldehyde dehydrogenase family
EPA93_RS10970	COG1063	alcohol dehydrogenase
EPA93_RS10975	COG0235	Class ii aldolase
EPA93_RS10980	COG0588	phosphoglycerate mutase activity
EPA93_RS10985	COG1070	Carbohydrate kinase
EPA93_RS10995	COG2390	Transcriptional regulator
EPA93_RS11005	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EPA93_RS11015	COG3775	system Galactitol-specific IIC component
EPA93_RS11035	COG0604	alcohol dehydrogenase
EPA93_RS11035	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS11035	COG3321	synthase
EPA93_RS11060	COG0477	Major facilitator Superfamily
EPA93_RS11100	COG3361	conserved protein (COG2071)
EPA93_RS11110	COG0778	Nitroreductase
EPA93_RS11115	COG2814	Major facilitator Superfamily
EPA93_RS11160	COG1280	lysine exporter protein (LysE YggA)
EPA93_RS11330	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EPA93_RS11395	COG0596	Alpha beta hydrolase
EPA93_RS11400	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EPA93_RS11460	COG1058	Belongs to the CinA family
EPA93_RS11460	COG1546	Belongs to the CinA family
EPA93_RS11490	COG1335	isochorismatase
EPA93_RS11510	COG0590	tRNA wobble adenosine to inosine editing
EPA93_RS11515	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EPA93_RS11520	COG1672	PFAM Archaeal ATPase
EPA93_RS11520	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
EPA93_RS11525	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EPA93_RS11540	COG1215	transferase activity, transferring glycosyl groups
EPA93_RS11545	COG4585	Histidine kinase
EPA93_RS11550	COG3548	integral membrane protein
EPA93_RS11555	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EPA93_RS11570	COG1733	regulation of RNA biosynthetic process
EPA93_RS11580	COG4106	trans-aconitate 2-methyltransferase activity
EPA93_RS11600	COG1063	alcohol dehydrogenase
EPA93_RS11615	COG1942	4-Oxalocrotonate Tautomerase
EPA93_RS11625	COG1309	transcriptional regulator
EPA93_RS11645	COG2860	membrane
EPA93_RS11665	COG0477	Major facilitator Superfamily
EPA93_RS11695	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EPA93_RS11720	COG1247	-acetyltransferase
EPA93_RS11725	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS11755	COG0583	DNA-binding transcription factor activity
EPA93_RS11775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS11800	COG0154	amidase activity
EPA93_RS11805	COG1396	sequence-specific DNA binding
EPA93_RS11815	COG0492	ferredoxin-NADP+ reductase activity
EPA93_RS11830	COG2022	thiamine diphosphate biosynthetic process
EPA93_RS11835	COG0352	thiamine-phosphate diphosphorylase activity
EPA93_RS11850	COG2382	esterase
EPA93_RS11895	COG2197	response regulator
EPA93_RS11910	COG0596	Alpha beta hydrolase
EPA93_RS11930	COG0277	FAD linked oxidase domain protein
EPA93_RS11945	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EPA93_RS11955	COG1172	Belongs to the binding-protein-dependent transport system permease family
EPA93_RS11965	COG1129	ABC transporter
EPA93_RS11985	COG1063	alcohol dehydrogenase
EPA93_RS12020	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EPA93_RS12035	COG1522	sequence-specific DNA binding
EPA93_RS12040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS12050	COG0628	permease
EPA93_RS12060	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EPA93_RS12085	COG1595	DNA-templated transcription, initiation
EPA93_RS12095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPA93_RS12120	COG5002	protein histidine kinase activity
EPA93_RS12130	COG2197	response regulator
EPA93_RS12140	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EPA93_RS12145	COG1181	Belongs to the D-alanine--D-alanine ligase family
EPA93_RS12150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPA93_RS12160	COG2909	trisaccharide binding
EPA93_RS12170	COG2124	cytochrome p450
EPA93_RS12185	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EPA93_RS12190	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EPA93_RS12260	COG1653	transport
EPA93_RS12280	COG2909	trisaccharide binding
EPA93_RS12285	COG2755	lipolytic protein G-D-S-L family
EPA93_RS12285	COG0657	acetylesterase activity
EPA93_RS12295	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS12325	COG1595	DNA-templated transcription, initiation
EPA93_RS12330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EPA93_RS12355	COG2226	methyltransferase
EPA93_RS12360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS12395	COG4978	Transcriptional regulator
EPA93_RS12395	COG0789	Transcriptional regulator
EPA93_RS12400	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS12415	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EPA93_RS12420	COG0505	Belongs to the CarA family
EPA93_RS12425	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EPA93_RS12440	COG3537	Alpha-1,2-mannosidase
EPA93_RS12465	COG1506	peptidase
EPA93_RS12465	COG4946	Tricorn protease homolog
EPA93_RS12465	COG0823	Involved in the tonB-independent uptake of proteins
EPA93_RS12475	COG1660	Displays ATPase and GTPase activities
EPA93_RS12510	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EPA93_RS12530	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EPA93_RS12535	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EPA93_RS12570	COG2226	methyltransferase
EPA93_RS12575	COG2342	PFAM TM1410 hypothetical-related protein
EPA93_RS12585	COG0628	permease
EPA93_RS12590	COG0628	permease
EPA93_RS12600	COG2226	methyltransferase
EPA93_RS12615	COG1131	(ABC) transporter
EPA93_RS12635	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EPA93_RS12640	COG0072	phenylalanine-tRNA ligase activity
EPA93_RS12640	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPA93_RS12650	COG2378	regulation of single-species biofilm formation
EPA93_RS12660	COG1993	acr, cog1993
EPA93_RS12675	COG0302	gtp cyclohydrolase
EPA93_RS12690	COG1733	regulation of RNA biosynthetic process
EPA93_RS12700	COG0076	glutamate decarboxylase activity
EPA93_RS12710	COG0673	inositol 2-dehydrogenase activity
EPA93_RS12715	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPA93_RS12735	COG0604	alcohol dehydrogenase
EPA93_RS12740	COG4106	trans-aconitate 2-methyltransferase activity
EPA93_RS12745	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EPA93_RS12765	COG0596	Alpha beta hydrolase
EPA93_RS12770	COG2909	trisaccharide binding
EPA93_RS12780	COG0667	Aldo Keto reductase
EPA93_RS12785	COG2815	serine threonine protein kinase
EPA93_RS12785	COG0515	serine threonine protein kinase
EPA93_RS12800	COG2814	Major facilitator Superfamily
EPA93_RS12805	COG1733	regulation of RNA biosynthetic process
EPA93_RS12810	COG1595	DNA-templated transcription, initiation
EPA93_RS12815	COG1070	Carbohydrate kinase
EPA93_RS12840	COG2226	methyltransferase
EPA93_RS12875	COG1846	Transcriptional regulator
EPA93_RS12915	COG2814	Major facilitator Superfamily
EPA93_RS12920	COG3408	Glycogen debranching enzyme
EPA93_RS12935	COG1131	(ABC) transporter
EPA93_RS12945	COG4152	abc transporter atp-binding protein
EPA93_RS12950	COG1668	transmembrane transport
EPA93_RS13005	COG4948	Mandelate Racemase Muconate Lactonizing
EPA93_RS13010	COG2186	Transcriptional regulator
EPA93_RS13020	COG1175	transmembrane transport
EPA93_RS13025	COG0395	ABC-type sugar transport system, permease component
EPA93_RS13055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EPA93_RS13070	COG1132	(ABC) transporter
EPA93_RS13075	COG1132	(ABC) transporter
EPA93_RS13090	COG0789	Transcriptional regulator
EPA93_RS13115	COG0477	Major facilitator Superfamily
EPA93_RS13150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EPA93_RS13185	COG0477	Major facilitator Superfamily
EPA93_RS13215	COG0656	L-ascorbic acid biosynthetic process
EPA93_RS13220	COG0657	acetylesterase activity
EPA93_RS13260	COG0436	Aminotransferase
EPA93_RS13275	COG1175	transmembrane transport
EPA93_RS13280	COG0395	ABC-type sugar transport system, permease component
EPA93_RS13330	COG2909	trisaccharide binding
EPA93_RS13350	COG2814	Major facilitator Superfamily
EPA93_RS13380	COG2814	Major facilitator Superfamily
EPA93_RS13385	COG0395	ABC-type sugar transport system, permease component
EPA93_RS13390	COG1175	transmembrane transport
EPA93_RS13395	COG1653	transport
EPA93_RS13400	COG1609	Transcriptional regulator
EPA93_RS13405	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EPA93_RS13415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EPA93_RS13420	COG1733	regulation of RNA biosynthetic process
EPA93_RS13450	COG1309	transcriptional regulator
EPA93_RS13460	COG1609	Transcriptional regulator
EPA93_RS13465	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS13475	COG2814	Major facilitator Superfamily
EPA93_RS13480	COG1695	Transcriptional regulator
EPA93_RS13490	COG0456	acetyltransferase
EPA93_RS13490	COG0454	-acetyltransferase
EPA93_RS13495	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EPA93_RS13505	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EPA93_RS13515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPA93_RS13520	COG0601	transmembrane transport
EPA93_RS13525	COG0747	negative chemotaxis
EPA93_RS13535	COG1609	Transcriptional regulator
EPA93_RS13545	COG2169	Transcriptional regulator
EPA93_RS13605	COG0747	negative chemotaxis
EPA93_RS13610	COG0747	negative chemotaxis
EPA93_RS13630	COG4166	transmembrane transport
EPA93_RS13645	COG0531	amino acid
EPA93_RS13650	COG2222	sugar isomerase
EPA93_RS13655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPA93_RS13660	COG2188	Transcriptional regulator
EPA93_RS13700	COG1024	Enoyl-CoA hydratase
EPA93_RS13720	COG2130	NADP-dependent
EPA93_RS13730	COG0477	Major facilitator Superfamily
EPA93_RS13745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPA93_RS13760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EPA93_RS13790	COG0277	FAD linked oxidase domain protein
EPA93_RS13795	COG1846	Transcriptional regulator
EPA93_RS13810	COG1999	signal sequence binding
EPA93_RS13895	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EPA93_RS13900	COG0747	negative chemotaxis
EPA93_RS13915	COG4106	trans-aconitate 2-methyltransferase activity
EPA93_RS13920	COG1595	DNA-templated transcription, initiation
EPA93_RS13940	COG1819	glycosyl
EPA93_RS13945	COG0367	asparagine synthase
EPA93_RS13950	COG0436	Aminotransferase
EPA93_RS13955	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
EPA93_RS13960	COG1104	cysteine desulfurase activity
EPA93_RS13965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS14000	COG1653	transport
EPA93_RS14020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPA93_RS14025	COG0601	transmembrane transport
EPA93_RS14030	COG0747	negative chemotaxis
EPA93_RS14035	COG1609	Transcriptional regulator
EPA93_RS14040	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EPA93_RS14070	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EPA93_RS14095	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EPA93_RS14155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EPA93_RS14165	COG1012	belongs to the aldehyde dehydrogenase family
EPA93_RS14175	COG2271	Major facilitator Superfamily
EPA93_RS14180	COG2814	Major facilitator Superfamily
EPA93_RS14185	COG2909	trisaccharide binding
EPA93_RS14200	COG2378	regulation of single-species biofilm formation
EPA93_RS14215	COG1309	transcriptional regulator
EPA93_RS14225	COG1131	(ABC) transporter
EPA93_RS14245	COG0477	Major facilitator Superfamily
EPA93_RS14260	COG2116	formate transmembrane transporter activity
EPA93_RS14265	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EPA93_RS14270	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EPA93_RS14290	COG2197	response regulator
EPA93_RS14350	COG0395	ABC-type sugar transport system, permease component
EPA93_RS14360	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
EPA93_RS14395	COG1309	transcriptional regulator
EPA93_RS14410	COG0583	DNA-binding transcription factor activity
EPA93_RS14415	COG0477	Major facilitator Superfamily
EPA93_RS14420	COG0477	Major facilitator Superfamily
EPA93_RS14445	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EPA93_RS14450	COG3226	Transcriptional regulator
EPA93_RS14460	COG0673	inositol 2-dehydrogenase activity
EPA93_RS14470	COG0363	glucosamine-6-phosphate deaminase activity
EPA93_RS14485	COG2188	Transcriptional regulator
EPA93_RS14495	COG1175	transmembrane transport
EPA93_RS14515	COG2226	methyltransferase
EPA93_RS14525	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EPA93_RS14555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPA93_RS14560	COG2909	trisaccharide binding
EPA93_RS14580	COG0789	Transcriptional regulator
EPA93_RS14605	COG0557	exoribonuclease II activity
EPA93_RS14620	COG0789	Transcriptional regulator
EPA93_RS14625	COG0667	Aldo Keto reductase
EPA93_RS14630	COG0667	Aldo Keto reductase
EPA93_RS14640	COG2909	trisaccharide binding
EPA93_RS14710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EPA93_RS14715	COG1960	acyl-CoA dehydrogenase activity
EPA93_RS14730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS14735	COG2124	cytochrome p450
EPA93_RS14740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS14745	COG2226	methyltransferase
EPA93_RS14755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EPA93_RS14765	COG4638	Rieske (2fe-2S)
EPA93_RS14775	COG2986	histidine ammonia-lyase
EPA93_RS14780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EPA93_RS14785	COG0156	8-amino-7-oxononanoate synthase activity
EPA93_RS14790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EPA93_RS14795	COG0318	PFAM AMP-dependent synthetase and ligase
EPA93_RS14800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EPA93_RS14815	COG4122	O-methyltransferase activity
EPA93_RS14930	COG0306	phosphate transporter
EPA93_RS14985	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EPA93_RS15005	COG1172	Belongs to the binding-protein-dependent transport system permease family
EPA93_RS15135	COG0165	Argininosuccinate lyase
EPA93_RS15145	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EPA93_RS15195	COG0657	acetylesterase activity
EPA93_RS15245	COG2909	trisaccharide binding
EPA93_RS15290	COG0156	8-amino-7-oxononanoate synthase activity
EPA93_RS15300	COG2124	cytochrome p450
EPA93_RS15355	COG4249	Peptidase C14 caspase catalytic subunit p20
EPA93_RS15355	COG2319	Wd-40 repeat
EPA93_RS15370	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EPA93_RS15380	COG2801	Transposase and inactivated derivatives
EPA93_RS15425	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EPA93_RS15485	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EPA93_RS15490	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EPA93_RS15605	COG2274	protein secretion by the type I secretion system
EPA93_RS15630	COG3335	DDE superfamily endonuclease
EPA93_RS15675	COG1309	transcriptional regulator
EPA93_RS15685	COG1819	glycosyl
EPA93_RS15700	COG1309	transcriptional regulator
EPA93_RS15705	COG1562	ergosterol biosynthetic process
EPA93_RS15725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPA93_RS15725	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
EPA93_RS15775	COG1725	Transcriptional regulator
EPA93_RS15840	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EPA93_RS15860	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EPA93_RS15860	COG0825	malonyl-CoA metabolic process
EPA93_RS15885	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EPA93_RS15885	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS15885	COG3321	synthase
EPA93_RS15885	COG0300	oxidoreductase activity
EPA93_RS15885	COG0318	PFAM AMP-dependent synthetase and ligase
EPA93_RS15895	COG2814	Major facilitator Superfamily
EPA93_RS15900	COG1309	transcriptional regulator
EPA93_RS15905	COG2124	cytochrome p450
EPA93_RS15910	COG2814	Major facilitator Superfamily
EPA93_RS15920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EPA93_RS15925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EPA93_RS15945	COG0535	radical SAM domain protein
EPA93_RS15960	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EPA93_RS15970	COG1216	Glycosyl transferase, family 2
EPA93_RS15995	COG0142	geranyltranstransferase activity
EPA93_RS16010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EPA93_RS16015	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EPA93_RS16020	COG1657	PFAM Prenyltransferase squalene oxidase
EPA93_RS16035	COG2226	methyltransferase
EPA93_RS16060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS16065	COG2814	Major facilitator Superfamily
EPA93_RS16090	COG0745	RESPONSE REGULATOR receiver
EPA93_RS16095	COG5002	protein histidine kinase activity
EPA93_RS16115	COG2094	Belongs to the DNA glycosylase MPG family
EPA93_RS16140	COG1175	transmembrane transport
EPA93_RS16145	COG0395	ABC-type sugar transport system, permease component
EPA93_RS16155	COG0583	DNA-binding transcription factor activity
EPA93_RS16165	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EPA93_RS16180	COG1169	isochorismate synthase
EPA93_RS16195	COG3383	formate dehydrogenase (NAD+) activity
EPA93_RS16200	COG4106	trans-aconitate 2-methyltransferase activity
EPA93_RS16210	COG2226	methyltransferase
EPA93_RS16265	COG1063	alcohol dehydrogenase
EPA93_RS16270	COG1309	transcriptional regulator
EPA93_RS16320	COG0367	asparagine synthase
EPA93_RS16360	COG0515	serine threonine protein kinase
EPA93_RS16390	COG2124	cytochrome p450
EPA93_RS16400	COG1304	FMN binding
EPA93_RS16405	COG1404	Belongs to the peptidase S8 family
EPA93_RS16410	COG0515	serine threonine protein kinase
EPA93_RS16460	COG0714	Associated with various cellular activities
EPA93_RS16490	COG2124	cytochrome p450
EPA93_RS16500	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EPA93_RS16505	COG1113	amino acid transport
EPA93_RS16515	COG0129	dihydroxy-acid dehydratase activity
EPA93_RS16520	COG0583	DNA-binding transcription factor activity
EPA93_RS16525	COG0436	Aminotransferase
EPA93_RS16530	COG1619	proteins homologs of microcin C7 resistance protein MccF
EPA93_RS16555	COG1609	Transcriptional regulator
EPA93_RS16565	COG1253	flavin adenine dinucleotide binding
EPA93_RS16595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS16605	COG4221	oxidoreductase activity
EPA93_RS16605	COG3321	synthase
EPA93_RS16605	COG0604	alcohol dehydrogenase
EPA93_RS16605	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EPA93_RS16610	COG3340	Belongs to the peptidase S51 family
EPA93_RS16620	COG2226	methyltransferase
EPA93_RS16635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS16640	COG2378	regulation of single-species biofilm formation
EPA93_RS16665	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EPA93_RS16680	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EPA93_RS16685	COG1522	sequence-specific DNA binding
EPA93_RS16695	COG0366	Alpha amylase catalytic
EPA93_RS16790	COG1132	(ABC) transporter
EPA93_RS16835	COG0582	viral genome integration into host DNA
EPA93_RS16840	COG0515	serine threonine protein kinase
EPA93_RS16845	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EPA93_RS16845	COG0438	transferase activity, transferring glycosyl groups
EPA93_RS16850	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
EPA93_RS16855	COG1716	ATPase activity
EPA93_RS16860	COG2188	Transcriptional regulator
EPA93_RS16865	COG1397	ADP-ribosylglycohydrolase
EPA93_RS16880	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EPA93_RS16910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EPA93_RS16920	COG2909	trisaccharide binding
EPA93_RS16930	COG5002	protein histidine kinase activity
EPA93_RS16960	COG0583	DNA-binding transcription factor activity
EPA93_RS16965	COG2079	MmgE PrpD family protein
EPA93_RS16980	COG0789	Transcriptional regulator
EPA93_RS16980	COG4978	Transcriptional regulator
EPA93_RS16990	COG4585	Histidine kinase
EPA93_RS17010	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EPA93_RS17020	COG1122	ATPase activity
EPA93_RS17035	COG0484	heat shock protein binding
EPA93_RS17040	COG0443	Heat shock 70 kDa protein
EPA93_RS17055	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EPA93_RS17070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EPA93_RS17075	COG3619	membrane
EPA93_RS17080	COG1797	cobyrinic acid a,c-diamide synthase activity
EPA93_RS17085	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
EPA93_RS17090	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS17095	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EPA93_RS17100	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS17105	COG1917	Cupin 2, conserved barrel domain protein
EPA93_RS17105	COG2207	Transcriptional regulator
EPA93_RS17115	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EPA93_RS17120	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
EPA93_RS17145	COG1024	Enoyl-CoA hydratase
EPA93_RS17155	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EPA93_RS17160	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS17165	COG2814	Major facilitator Superfamily
EPA93_RS17210	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EPA93_RS17215	COG1802	Transcriptional regulator
EPA93_RS17230	COG1132	(ABC) transporter
EPA93_RS17235	COG1132	(ABC) transporter
EPA93_RS17240	COG2188	Transcriptional regulator
EPA93_RS17265	COG2197	response regulator
EPA93_RS17270	COG4585	Histidine kinase
EPA93_RS17275	COG1136	(ABC) transporter
EPA93_RS17285	COG2909	trisaccharide binding
EPA93_RS17295	COG4221	oxidoreductase activity
EPA93_RS17310	COG0745	RESPONSE REGULATOR receiver
EPA93_RS17315	COG1725	Transcriptional regulator
EPA93_RS17345	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EPA93_RS17365	COG1846	Transcriptional regulator
EPA93_RS17370	COG3321	synthase
EPA93_RS17370	COG0604	alcohol dehydrogenase
EPA93_RS17420	COG0243	molybdopterin cofactor binding
EPA93_RS17435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EPA93_RS17490	COG1994	Peptidase M50
EPA93_RS17520	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS17530	COG2186	Transcriptional regulator
EPA93_RS17535	COG0438	transferase activity, transferring glycosyl groups
EPA93_RS17605	COG0837	glucose binding
EPA93_RS17640	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EPA93_RS17670	COG1072	(Pantothenic acid kinase))
EPA93_RS17675	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EPA93_RS17705	COG0745	RESPONSE REGULATOR receiver
EPA93_RS17725	COG2909	trisaccharide binding
EPA93_RS17740	COG1846	Transcriptional regulator
EPA93_RS17745	COG0859	PFAM glycosyl transferase family 9
EPA93_RS17760	COG0776	regulation of translation
EPA93_RS17770	COG1612	heme a metabolic process
EPA93_RS17775	COG0564	pseudouridine synthase activity
EPA93_RS17780	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EPA93_RS17785	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EPA93_RS17790	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EPA93_RS17795	COG1611	Belongs to the LOG family
EPA93_RS17800	COG1461	Dihydroxyacetone kinase
EPA93_RS17805	COG2376	Dihydroxyacetone kinase
EPA93_RS17815	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EPA93_RS17820	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EPA93_RS17835	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EPA93_RS17840	COG0501	Belongs to the peptidase M48B family
EPA93_RS17850	COG0577	efflux transmembrane transporter activity
EPA93_RS17865	COG4946	Tricorn protease homolog
EPA93_RS17865	COG1506	peptidase
EPA93_RS17865	COG0823	Involved in the tonB-independent uptake of proteins
EPA93_RS17875	COG2368	4-hydroxyphenylacetate
EPA93_RS17920	COG4555	ABC transporter
EPA93_RS17945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EPA93_RS17950	COG1802	Transcriptional regulator
EPA93_RS17955	COG2188	Transcriptional regulator
EPA93_RS17970	COG4821	SIS domain
EPA93_RS17975	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EPA93_RS17980	COG4716	Myosin-crossreactive antigen
EPA93_RS18020	COG0180	Tryptophanyl-tRNA synthetase
EPA93_RS18030	COG0512	Glutamine amidotransferase of anthranilate synthase
EPA93_RS18035	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EPA93_RS18045	COG0133	tryptophan synthase activity
EPA93_RS18055	COG0159	tryptophan synthase activity
EPA93_RS18060	COG0789	Transcriptional regulator
EPA93_RS18065	COG0306	phosphate transporter
EPA93_RS18095	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EPA93_RS18100	COG1414	Transcriptional regulator
EPA93_RS18105	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EPA93_RS18130	COG1609	Transcriptional regulator
EPA93_RS18215	COG0028	Belongs to the TPP enzyme family
EPA93_RS18220	COG2814	Major facilitator Superfamily
EPA93_RS18225	COG2971	BadF BadG BcrA BcrD
EPA93_RS18230	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
EPA93_RS18235	COG1309	transcriptional regulator
EPA93_RS18245	COG2721	sulfolactate sulfo-lyase activity
EPA93_RS18265	COG0515	serine threonine protein kinase
EPA93_RS18265	COG2815	serine threonine protein kinase
EPA93_RS18275	COG2226	methyltransferase
EPA93_RS18290	COG1960	acyl-CoA dehydrogenase activity
EPA93_RS18295	COG0251	oxidation-reduction process
EPA93_RS18315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS18325	COG1917	Cupin 2, conserved barrel domain protein
EPA93_RS18325	COG2207	Transcriptional regulator
EPA93_RS18330	COG0076	glutamate decarboxylase activity
EPA93_RS18335	COG0352	thiamine-phosphate diphosphorylase activity
EPA93_RS18340	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EPA93_RS18345	COG0351	phosphomethylpyrimidine kinase
EPA93_RS18380	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
EPA93_RS18385	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS18395	COG2205	protein histidine kinase activity
EPA93_RS18415	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EPA93_RS18420	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EPA93_RS18425	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EPA93_RS18445	COG1846	Transcriptional regulator
EPA93_RS18450	COG2815	serine threonine protein kinase
EPA93_RS18450	COG0515	serine threonine protein kinase
EPA93_RS18460	COG5002	protein histidine kinase activity
EPA93_RS18460	COG3850	Histidine kinase
EPA93_RS18470	COG0406	alpha-ribazole phosphatase activity
EPA93_RS18475	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EPA93_RS18480	COG3387	PFAM Glycoside hydrolase 15-related
EPA93_RS18485	COG0113	porphobilinogen synthase activity
EPA93_RS18490	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EPA93_RS18495	COG3253	May function as heme-dependent peroxidase
EPA93_RS18500	COG1587	Uroporphyrinogen-III synthase
EPA93_RS18505	COG0181	hydroxymethylbilane synthase activity
EPA93_RS18510	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EPA93_RS18535	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EPA93_RS18540	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EPA93_RS18545	COG3404	Formiminotransferase-cyclodeaminase
EPA93_RS18555	COG1122	ATPase activity
EPA93_RS18565	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EPA93_RS18580	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EPA93_RS18600	COG4221	oxidoreductase activity
EPA93_RS18620	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS18625	COG2226	methyltransferase
EPA93_RS18640	COG0740	serine-type endopeptidase activity
EPA93_RS18645	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EPA93_RS18660	COG0166	Belongs to the GPI family
EPA93_RS18670	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EPA93_RS18695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EPA93_RS18700	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EPA93_RS18720	COG3552	Protein containing von Willebrand factor type A (VWA) domain
EPA93_RS18730	COG0714	Associated with various cellular activities
EPA93_RS18770	COG0667	Aldo Keto reductase
EPA93_RS18775	COG2816	NAD+ diphosphatase activity
EPA93_RS18780	COG0107	imidazoleglycerol-phosphate synthase activity
EPA93_RS18785	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EPA93_RS18790	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EPA93_RS18800	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EPA93_RS18810	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EPA93_RS18825	COG0515	serine threonine protein kinase
EPA93_RS18825	COG2815	serine threonine protein kinase
EPA93_RS18840	COG0515	serine threonine protein kinase
EPA93_RS18840	COG2815	serine threonine protein kinase
EPA93_RS18845	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EPA93_RS18850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EPA93_RS18860	COG1294	oxidase, subunit
EPA93_RS18865	COG1271	oxidase subunit
EPA93_RS18870	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EPA93_RS18875	COG4988	ABC transporter
EPA93_RS18910	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EPA93_RS18915	COG1920	GTP binding
EPA93_RS18930	COG0174	glutamine synthetase
EPA93_RS18935	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EPA93_RS18950	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EPA93_RS18960	COG0631	protein serine/threonine phosphatase activity
EPA93_RS18965	COG1196	nuclear chromosome segregation
EPA93_RS18975	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EPA93_RS18980	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EPA93_RS18995	COG0789	Transcriptional regulator
EPA93_RS19020	COG1215	transferase activity, transferring glycosyl groups
EPA93_RS19050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EPA93_RS19055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPA93_RS19060	COG4946	Tricorn protease homolog
EPA93_RS19060	COG1506	peptidase
EPA93_RS19060	COG0823	Involved in the tonB-independent uptake of proteins
EPA93_RS19080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EPA93_RS19085	COG1554	hydrolase, family 65, central catalytic
EPA93_RS19095	COG0582	viral genome integration into host DNA
EPA93_RS19250	COG2309	aminopeptidase activity
EPA93_RS19275	COG1316	TRANSCRIPTIONal
EPA93_RS19280	COG0515	serine threonine protein kinase
EPA93_RS19280	COG2815	serine threonine protein kinase
EPA93_RS19295	COG0460	homoserine dehydrogenase
EPA93_RS19305	COG0728	peptidoglycan biosynthetic process
EPA93_RS19310	COG0728	peptidoglycan biosynthetic process
EPA93_RS19325	COG0405	Gamma-glutamyltransferase
EPA93_RS19330	COG0215	cysteine-tRNA ligase activity
EPA93_RS19340	COG1164	Oligoendopeptidase f
EPA93_RS19370	COG2079	MmgE PrpD family protein
EPA93_RS19375	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EPA93_RS19380	COG1522	sequence-specific DNA binding
EPA93_RS19425	COG2378	regulation of single-species biofilm formation
EPA93_RS19430	COG4608	Belongs to the ABC transporter superfamily
EPA93_RS19435	COG0444	Belongs to the ABC transporter superfamily
EPA93_RS19440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPA93_RS19445	COG0601	transmembrane transport
EPA93_RS19460	COG0383	alpha-mannosidase activity
EPA93_RS19480	COG0515	serine threonine protein kinase
EPA93_RS19480	COG2815	serine threonine protein kinase
EPA93_RS19485	COG3387	PFAM Glycoside hydrolase 15-related
EPA93_RS19495	COG1217	gtp-binding protein TYPA
EPA93_RS19510	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EPA93_RS19520	COG0823	Involved in the tonB-independent uptake of proteins
EPA93_RS19520	COG1506	peptidase
EPA93_RS19520	COG4946	Tricorn protease homolog
EPA93_RS19555	COG0529	Catalyzes the synthesis of activated sulfate
EPA93_RS19565	COG0357	Ribosomal RNA small subunit methyltransferase G
EPA93_RS19580	COG3158	transport of potassium into the cell
EPA93_RS19600	COG0411	ABC transporter
EPA93_RS19630	COG0237	dephospho-CoA kinase activity
EPA93_RS19640	COG0488	(ABC) transporter
EPA93_RS19645	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EPA93_RS19665	COG0116	Belongs to the methyltransferase superfamily
EPA93_RS19665	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EPA93_RS19680	COG1695	Transcriptional regulator
EPA93_RS19685	COG0583	DNA-binding transcription factor activity
EPA93_RS19730	COG2188	Transcriptional regulator
EPA93_RS19735	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
EPA93_RS19740	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EPA93_RS19805	COG1595	DNA-templated transcription, initiation
EPA93_RS19820	COG0745	RESPONSE REGULATOR receiver
EPA93_RS19825	COG0745	RESPONSE REGULATOR receiver
EPA93_RS19830	COG5002	protein histidine kinase activity
EPA93_RS19835	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EPA93_RS19845	COG4585	Histidine kinase
EPA93_RS19850	COG2197	response regulator
EPA93_RS19865	COG1595	DNA-templated transcription, initiation
EPA93_RS19870	COG0529	Catalyzes the synthesis of activated sulfate
EPA93_RS19875	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EPA93_RS19885	COG0601	transmembrane transport
EPA93_RS19890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPA93_RS19895	COG4636	protein conserved in cyanobacteria
EPA93_RS19910	COG0596	Alpha beta hydrolase
EPA93_RS19960	COG3848	Pyruvate phosphate dikinase
EPA93_RS19960	COG0574	Belongs to the PEP-utilizing enzyme family
EPA93_RS19965	COG1309	transcriptional regulator
EPA93_RS20030	COG4585	Histidine kinase
EPA93_RS20035	COG2815	serine threonine protein kinase
EPA93_RS20035	COG0515	serine threonine protein kinase
EPA93_RS20055	COG0789	Transcriptional regulator
EPA93_RS20060	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EPA93_RS20070	COG0463	Glycosyl transferase, family 2
EPA93_RS20080	COG1309	transcriptional regulator
EPA93_RS20085	COG2076	Multidrug Resistance protein
EPA93_RS20100	COG0123	including yeast histone deacetylase and acetoin utilization protein
EPA93_RS20120	COG0823	Involved in the tonB-independent uptake of proteins
EPA93_RS20120	COG1506	peptidase
EPA93_RS20120	COG4946	Tricorn protease homolog
EPA93_RS20140	COG5002	protein histidine kinase activity
EPA93_RS20145	COG0745	RESPONSE REGULATOR receiver
EPA93_RS20150	COG0477	Major facilitator Superfamily
EPA93_RS20155	COG0318	PFAM AMP-dependent synthetase and ligase
EPA93_RS20170	COG0483	inositol monophosphate 1-phosphatase activity
EPA93_RS20175	COG1376	ErfK ybiS ycfS ynhG family protein
EPA93_RS20190	COG0438	transferase activity, transferring glycosyl groups
EPA93_RS20205	COG1937	Protein conserved in bacteria
EPA93_RS20215	COG4585	Histidine kinase
EPA93_RS20220	COG2197	response regulator
EPA93_RS20235	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EPA93_RS20240	COG1122	ATPase activity
EPA93_RS20245	COG1122	ATPase activity
EPA93_RS20255	COG0210	DNA helicase
EPA93_RS20260	COG0730	response to heat
EPA93_RS20275	COG1116	anion transmembrane transporter activity
EPA93_RS20280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EPA93_RS20285	COG0730	response to heat
EPA93_RS20305	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EPA93_RS20345	COG2362	D-Aminopeptidase
EPA93_RS20350	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EPA93_RS20355	COG1085	galactose-1-phosphate uridylyltransferase
EPA93_RS20365	COG2226	methyltransferase
EPA93_RS20385	COG0515	serine threonine protein kinase
EPA93_RS20385	COG2815	serine threonine protein kinase
EPA93_RS20390	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EPA93_RS20395	COG0799	negative regulation of ribosome biogenesis
EPA93_RS20410	COG1486	melibiose metabolic process
EPA93_RS20415	COG0277	FAD linked oxidase domain protein
EPA93_RS20420	COG0277	FAD linked oxidase domain protein
EPA93_RS20425	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
EPA93_RS20430	COG0247	lactate metabolic process
EPA93_RS20445	COG0287	Prephenate dehydrogenase
EPA93_RS20455	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EPA93_RS20465	COG0753	catalase activity
EPA93_RS20470	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EPA93_RS20500	COG2390	Transcriptional regulator
EPA93_RS20520	COG0745	RESPONSE REGULATOR receiver
EPA93_RS20525	COG1309	transcriptional regulator
EPA93_RS20530	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS20535	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EPA93_RS20550	COG0606	chelatase, subunit chli
EPA93_RS20565	COG1120	ATPase activity
EPA93_RS20570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EPA93_RS20580	COG1573	uracil-dna glycosylase
EPA93_RS20585	COG0822	iron-sulfur transferase activity
EPA93_RS20590	COG2897	thiosulfate sulfurtransferase activity
EPA93_RS20595	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EPA93_RS20615	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
EPA93_RS20615	COG1672	PFAM Archaeal ATPase
EPA93_RS20635	COG2096	Adenosyltransferase
EPA93_RS20640	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EPA93_RS20660	COG0586	Pfam SNARE associated Golgi protein
EPA93_RS20670	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EPA93_RS20685	COG0019	diaminopimelate decarboxylase activity
EPA93_RS20705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EPA93_RS20720	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EPA93_RS20730	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EPA93_RS20735	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EPA93_RS20740	COG0116	Belongs to the methyltransferase superfamily
EPA93_RS20740	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EPA93_RS20750	COG0789	Transcriptional regulator
EPA93_RS20755	COG2814	Major facilitator Superfamily
EPA93_RS20785	COG0318	PFAM AMP-dependent synthetase and ligase
EPA93_RS20795	COG0285	dihydrofolate synthase activity
EPA93_RS20800	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EPA93_RS20810	COG0142	geranyltranstransferase activity
EPA93_RS20825	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
EPA93_RS20835	COG2814	Major facilitator Superfamily
EPA93_RS20845	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EPA93_RS20870	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EPA93_RS20875	COG0438	transferase activity, transferring glycosyl groups
EPA93_RS20880	COG4948	Mandelate Racemase Muconate Lactonizing
EPA93_RS20885	COG0006	proline dipeptidase activity
EPA93_RS20890	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS20905	COG2192	nodulation
EPA93_RS20925	COG0859	PFAM glycosyl transferase family 9
EPA93_RS20940	COG0463	Glycosyl transferase, family 2
EPA93_RS20955	COG0859	PFAM glycosyl transferase family 9
EPA93_RS20975	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EPA93_RS20980	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EPA93_RS20985	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS20990	COG0693	protein deglycase activity
EPA93_RS20995	COG2197	response regulator
EPA93_RS21000	COG1695	Transcriptional regulator
EPA93_RS21005	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EPA93_RS21010	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EPA93_RS21030	COG0395	ABC-type sugar transport system, permease component
EPA93_RS21035	COG1175	transmembrane transport
EPA93_RS21050	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EPA93_RS21055	COG2814	Major facilitator Superfamily
EPA93_RS21070	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EPA93_RS21085	COG2076	Multidrug Resistance protein
EPA93_RS21090	COG2076	Multidrug Resistance protein
EPA93_RS21095	COG0583	DNA-binding transcription factor activity
EPA93_RS21100	COG1610	YqeY-like protein
EPA93_RS21120	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EPA93_RS21125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EPA93_RS21130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EPA93_RS21145	COG1012	belongs to the aldehyde dehydrogenase family
EPA93_RS21220	COG0492	ferredoxin-NADP+ reductase activity
EPA93_RS21230	COG0726	polysaccharide deacetylase
EPA93_RS21235	COG0492	ferredoxin-NADP+ reductase activity
EPA93_RS21250	COG0489	protein tyrosine kinase activity
EPA93_RS21265	COG0438	transferase activity, transferring glycosyl groups
EPA93_RS21270	COG0438	transferase activity, transferring glycosyl groups
EPA93_RS21275	COG0367	asparagine synthase
EPA93_RS21300	COG0673	inositol 2-dehydrogenase activity
EPA93_RS21310	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EPA93_RS21320	COG0745	RESPONSE REGULATOR receiver
EPA93_RS21325	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
EPA93_RS21330	COG1722	exodeoxyribonuclease VII activity
EPA93_RS21335	COG1570	exodeoxyribonuclease VII activity
EPA93_RS21340	COG0511	ligase activity, forming carbon-carbon bonds
EPA93_RS21345	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EPA93_RS21350	COG0006	proline dipeptidase activity
EPA93_RS21355	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EPA93_RS21360	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EPA93_RS21370	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EPA93_RS21375	COG0750	zinc metalloprotease
EPA93_RS21380	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EPA93_RS21385	COG0575	Belongs to the CDS family
EPA93_RS21390	COG0575	Belongs to the CDS family
EPA93_RS21400	COG0233	cytoplasmic translational termination
EPA93_RS21405	COG0528	UMP kinase activity
EPA93_RS21410	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EPA93_RS21415	COG0052	Belongs to the universal ribosomal protein uS2 family
EPA93_RS21425	COG2197	response regulator
EPA93_RS21440	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EPA93_RS21455	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EPA93_RS21460	COG1100	Small GTP-binding protein
EPA93_RS21485	COG2207	Transcriptional regulator
EPA93_RS21490	COG0346	lactoylglutathione lyase activity
EPA93_RS21505	COG0604	alcohol dehydrogenase
EPA93_RS21505	COG3321	synthase
EPA93_RS21510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPA93_RS21540	COG0542	response to heat
EPA93_RS21565	COG0640	Transcriptional regulator
EPA93_RS21570	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EPA93_RS21575	COG0631	protein serine/threonine phosphatase activity
EPA93_RS21585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPA93_RS21620	COG0586	Pfam SNARE associated Golgi protein
EPA93_RS21645	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EPA93_RS21675	COG0481	GTPase activity
EPA93_RS21685	COG0393	Putative heavy-metal-binding
EPA93_RS21710	COG0297	glycogen (starch) synthase activity
EPA93_RS21745	COG2204	response regulator
EPA93_RS21760	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EPA93_RS21795	COG1100	Small GTP-binding protein
EPA93_RS21810	COG0517	IMP dehydrogenase activity
EPA93_RS21810	COG0516	GMP reductase activity
EPA93_RS21820	COG1131	(ABC) transporter
EPA93_RS21845	COG4608	Belongs to the ABC transporter superfamily
EPA93_RS21850	COG0444	Belongs to the ABC transporter superfamily
EPA93_RS21855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS21865	COG0477	Major facilitator Superfamily
EPA93_RS21890	COG1595	DNA-templated transcription, initiation
EPA93_RS21905	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
EPA93_RS21915	COG1596	polysaccharide export
EPA93_RS21915	COG1555	photosystem II stabilization
EPA93_RS21935	COG4974	Belongs to the 'phage' integrase family
EPA93_RS21960	COG0574	Belongs to the PEP-utilizing enzyme family
EPA93_RS21960	COG3848	Pyruvate phosphate dikinase
EPA93_RS21975	COG0745	RESPONSE REGULATOR receiver
EPA93_RS21980	COG5002	protein histidine kinase activity
EPA93_RS21990	COG4585	Histidine kinase
EPA93_RS22000	COG2226	methyltransferase
EPA93_RS22025	COG3732	PTS system glucitol sorbitol-specific
EPA93_RS22030	COG3732	PTS system glucitol sorbitol-specific
EPA93_RS22045	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EPA93_RS22050	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EPA93_RS22055	COG0022	dehydrogenase e1 component
EPA93_RS22055	COG0508	dehydrogenase complex catalyzes the overall conversion of
EPA93_RS22060	COG0508	dehydrogenase complex catalyzes the overall conversion of
EPA93_RS22065	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPA93_RS22070	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EPA93_RS22075	COG2390	Transcriptional regulator
EPA93_RS22095	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EPA93_RS22100	COG1575	Belongs to the MenA family. Type 1 subfamily
EPA93_RS22115	COG2217	Heavy metal translocating P-type atpase
EPA93_RS22130	COG1309	transcriptional regulator
EPA93_RS22135	COG2124	cytochrome p450
EPA93_RS22135	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EPA93_RS22140	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EPA93_RS22150	COG1122	ATPase activity
EPA93_RS22155	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EPA93_RS22160	COG0310	cobalt ion transport
EPA93_RS22180	COG4166	transmembrane transport
EPA93_RS22185	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EPA93_RS22200	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EPA93_RS22220	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EPA93_RS22235	COG0641	radical SAM
EPA93_RS22240	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EPA93_RS22265	COG2124	cytochrome p450
EPA93_RS22280	COG5002	protein histidine kinase activity
EPA93_RS22295	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EPA93_RS22300	COG1611	Belongs to the LOG family
EPA93_RS22310	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EPA93_RS22320	COG1691	(AIR) carboxylase
EPA93_RS22335	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EPA93_RS22350	COG2124	cytochrome p450
EPA93_RS22370	COG1234	tRNA 3'-trailer cleavage
EPA93_RS22385	COG0243	molybdopterin cofactor binding
EPA93_RS22400	COG5002	protein histidine kinase activity
EPA93_RS22435	COG0077	Prephenate dehydratase
EPA93_RS22435	COG1605	Chorismate mutase
EPA93_RS22445	COG2226	methyltransferase
EPA93_RS22480	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EPA93_RS22490	COG2267	carboxylic ester hydrolase activity
EPA93_RS22505	COG2814	Major facilitator Superfamily
EPA93_RS22510	COG0583	DNA-binding transcription factor activity
EPA93_RS22520	COG0515	serine threonine protein kinase
EPA93_RS22520	COG2815	serine threonine protein kinase
EPA93_RS22525	COG2353	YceI-like domain
EPA93_RS22530	COG0004	ammonium transporteR
EPA93_RS22565	COG0673	inositol 2-dehydrogenase activity
EPA93_RS22600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EPA93_RS22605	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EPA93_RS22615	COG1216	Glycosyl transferase, family 2
EPA93_RS22670	COG2304	oxidoreductase activity
EPA93_RS22675	COG4279	zinc finger
EPA93_RS22680	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EPA93_RS22695	COG1653	transport
EPA93_RS22715	COG2124	cytochrome p450
EPA93_RS22720	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EPA93_RS22750	COG0531	amino acid
EPA93_RS22770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EPA93_RS22775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPA93_RS22780	COG1116	anion transmembrane transporter activity
EPA93_RS22795	COG0698	ribose 5-phosphate isomerase
EPA93_RS22885	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EPA93_RS22890	COG1309	transcriptional regulator
EPA93_RS22895	COG1653	transport
EPA93_RS22925	COG1113	amino acid transport
EPA93_RS22930	COG0747	negative chemotaxis
EPA93_RS22935	COG4221	oxidoreductase activity
EPA93_RS22950	COG3387	PFAM Glycoside hydrolase 15-related
EPA93_RS22955	COG0028	Belongs to the TPP enzyme family
EPA93_RS22960	COG0247	lactate metabolic process
EPA93_RS22960	COG0277	FAD linked oxidase domain protein
EPA93_RS22985	COG0038	chloride channel
EPA93_RS23015	COG1175	transmembrane transport
EPA93_RS23020	COG0395	ABC-type sugar transport system, permease component
EPA93_RS23040	COG1176	ABC-type spermidine putrescine transport system, permease component I
EPA93_RS23045	COG0395	ABC-type sugar transport system, permease component
EPA93_RS23060	COG0735	belongs to the Fur family
EPA93_RS23075	COG0859	PFAM glycosyl transferase family 9
EPA93_RS23090	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
EPA93_RS23105	COG1595	DNA-templated transcription, initiation
EPA93_RS23110	COG0438	transferase activity, transferring glycosyl groups
EPA93_RS23115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPA93_RS23145	COG1234	tRNA 3'-trailer cleavage
EPA93_RS23155	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EPA93_RS23170	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
EPA93_RS23195	COG0671	phosphoesterase, PA-phosphatase related
EPA93_RS23200	COG2815	serine threonine protein kinase
EPA93_RS23200	COG0515	serine threonine protein kinase
EPA93_RS23210	COG3622	Belongs to the hyi family
EPA93_RS23265	COG2233	PERMEase
EPA93_RS23280	COG2084	Dehydrogenase
EPA93_RS23310	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EPA93_RS23315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EPA93_RS23335	COG1172	Belongs to the binding-protein-dependent transport system permease family
EPA93_RS23355	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EPA93_RS23360	COG4988	ABC transporter
EPA93_RS23365	COG1294	oxidase, subunit
EPA93_RS23370	COG1271	oxidase subunit
EPA93_RS23375	COG0667	Aldo Keto reductase
EPA93_RS23380	COG3195	allantoin biosynthetic process
EPA93_RS23380	COG3648	Uricase
EPA93_RS23385	COG2351	hydroxyisourate hydrolase activity
EPA93_RS23395	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EPA93_RS23405	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EPA93_RS23415	COG4585	Histidine kinase
EPA93_RS23420	COG2197	response regulator
EPA93_RS23435	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EPA93_RS23455	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EPA93_RS23495	COG0604	alcohol dehydrogenase
EPA93_RS23495	COG3321	synthase
EPA93_RS23515	COG0010	Belongs to the arginase family
EPA93_RS23520	COG0318	PFAM AMP-dependent synthetase and ligase
EPA93_RS23525	COG4608	Belongs to the ABC transporter superfamily
EPA93_RS23535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPA93_RS23540	COG0601	transmembrane transport
EPA93_RS23545	COG0747	negative chemotaxis
EPA93_RS23550	COG2188	Transcriptional regulator
EPA93_RS23555	COG2971	BadF BadG BcrA BcrD
EPA93_RS23560	COG1472	Belongs to the glycosyl hydrolase 3 family
EPA93_RS23565	COG3718	enzyme involved in inositol metabolism
EPA93_RS23570	COG0673	inositol 2-dehydrogenase activity
EPA93_RS23575	COG1683	Conserved Protein
EPA93_RS23600	COG0740	serine-type endopeptidase activity
EPA93_RS23620	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
EPA93_RS23625	COG0656	L-ascorbic acid biosynthetic process
EPA93_RS23630	COG2971	BadF BadG BcrA BcrD
EPA93_RS23635	COG1609	Transcriptional regulator
EPA93_RS23645	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EPA93_RS23650	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EPA93_RS23655	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EPA93_RS23660	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EPA93_RS23665	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EPA93_RS23670	COG1960	acyl-CoA dehydrogenase activity
EPA93_RS23725	COG1464	Belongs to the NlpA lipoprotein family
EPA93_RS23730	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EPA93_RS23735	COG2011	ABC-type metal ion transport system permease component
EPA93_RS23745	COG1063	alcohol dehydrogenase
EPA93_RS23750	COG1309	transcriptional regulator
EPA93_RS23755	COG1414	Transcriptional regulator
EPA93_RS23760	COG0673	inositol 2-dehydrogenase activity
EPA93_RS23770	COG4952	isomerase
EPA93_RS23775	COG1349	DNA-binding transcription factor activity
EPA93_RS23785	COG1271	oxidase subunit
EPA93_RS23790	COG1294	oxidase, subunit
EPA93_RS23795	COG4988	ABC transporter
EPA93_RS23800	COG1132	(ABC) transporter
EPA93_RS23810	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EPA93_RS23820	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EPA93_RS23830	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EPA93_RS23840	COG1082	Xylose isomerase domain protein TIM barrel
EPA93_RS23845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPA93_RS23850	COG1609	Transcriptional regulator
EPA93_RS23855	COG3254	rhamnose metabolic process
EPA93_RS23860	COG0515	serine threonine protein kinase
EPA93_RS23860	COG2815	serine threonine protein kinase
EPA93_RS23875	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EPA93_RS23885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EPA93_RS23885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPA93_RS23890	COG0477	Major facilitator Superfamily
EPA93_RS23895	COG1131	(ABC) transporter
EPA93_RS23910	COG1595	DNA-templated transcription, initiation
EPA93_RS23915	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EPA93_RS23920	COG1172	Belongs to the binding-protein-dependent transport system permease family
EPA93_RS23930	COG1129	ABC transporter
EPA93_RS23935	COG1879	ABC-type sugar transport system periplasmic component
EPA93_RS23950	COG2188	Transcriptional regulator
EPA93_RS23970	COG1609	Transcriptional regulator
EPA93_RS23975	COG1129	ABC transporter
EPA93_RS23980	COG1172	Belongs to the binding-protein-dependent transport system permease family
EPA93_RS24015	COG0488	(ABC) transporter
EPA93_RS24025	COG5564	TIM-barrel signal transduction protein
EPA93_RS24035	COG0318	PFAM AMP-dependent synthetase and ligase
EPA93_RS24040	COG2326	polyphosphate kinase activity
EPA93_RS24045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPA93_RS24055	COG0747	negative chemotaxis
EPA93_RS24065	COG4166	transmembrane transport
EPA93_RS24070	COG0601	transmembrane transport
EPA93_RS24075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPA93_RS24095	COG0395	ABC-type sugar transport system, permease component
EPA93_RS24125	COG1819	glycosyl
EPA93_RS24145	COG2423	ornithine cyclodeaminase activity
EPA93_RS24150	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EPA93_RS24160	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EPA93_RS24165	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EPA93_RS24170	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EPA93_RS24170	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EPA93_RS24185	COG0248	Ppx GppA phosphatase
EPA93_RS24210	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EPA93_RS24215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS24235	COG0693	protein deglycase activity
EPA93_RS24240	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EPA93_RS24250	COG4221	oxidoreductase activity
EPA93_RS24255	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
EPA93_RS24270	COG0205	6-phosphofructokinase activity
EPA93_RS24295	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EPA93_RS24295	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EPA93_RS24325	COG4221	oxidoreductase activity
EPA93_RS24355	COG3903	Transcriptional regulator
EPA93_RS24355	COG3629	intracellular signal transduction
EPA93_RS24385	COG0596	Alpha beta hydrolase
EPA93_RS24395	COG1309	transcriptional regulator
EPA93_RS24410	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EPA93_RS24430	COG1309	transcriptional regulator
EPA93_RS24465	COG0542	response to heat
EPA93_RS24470	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EPA93_RS24505	COG1595	DNA-templated transcription, initiation
EPA93_RS24525	COG0024	Methionine aminopeptidase
EPA93_RS24590	COG1595	DNA-templated transcription, initiation
EPA93_RS24595	COG2267	carboxylic ester hydrolase activity
EPA93_RS24610	COG5002	protein histidine kinase activity
EPA93_RS24620	COG3189	MarR family transcriptional regulator
EPA93_RS24630	COG0243	molybdopterin cofactor binding
EPA93_RS24635	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
EPA93_RS24675	COG1169	isochorismate synthase
EPA93_RS24680	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EPA93_RS24685	COG0596	Alpha beta hydrolase
EPA93_RS24690	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EPA93_RS24700	COG0318	PFAM AMP-dependent synthetase and ligase
EPA93_RS24750	COG0542	response to heat
EPA93_RS24765	COG1960	acyl-CoA dehydrogenase activity
EPA93_RS24775	COG0189	ligase activity
EPA93_RS24780	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EPA93_RS24800	COG0494	nUDIX hydrolase
EPA93_RS24805	COG1199	ATP-dependent helicase activity
EPA93_RS24815	COG0537	adenosine 5'-monophosphoramidase activity
EPA93_RS24830	COG0297	glycogen (starch) synthase activity
EPA93_RS24830	COG0438	transferase activity, transferring glycosyl groups
EPA93_RS24850	COG2815	serine threonine protein kinase
EPA93_RS24850	COG0515	serine threonine protein kinase
EPA93_RS24855	COG1716	ATPase activity
EPA93_RS24860	COG2815	serine threonine protein kinase
EPA93_RS24860	COG0515	serine threonine protein kinase
EPA93_RS24865	COG0745	RESPONSE REGULATOR receiver
EPA93_RS24885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EPA93_RS24895	COG0484	heat shock protein binding
EPA93_RS24905	COG0067	glutamate synthase
EPA93_RS24905	COG0069	glutamate synthase activity
EPA93_RS24905	COG0070	glutamate synthase
EPA93_RS24950	COG1051	belongs to the nudix hydrolase family
EPA93_RS24960	COG1733	regulation of RNA biosynthetic process
EPA93_RS24970	COG1250	3-hydroxyacyl-CoA dehydrogenase
EPA93_RS24995	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EPA93_RS25000	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EPA93_RS25015	COG0165	Argininosuccinate lyase
EPA93_RS25020	COG0137	argininosuccinate synthase activity
EPA93_RS25035	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EPA93_RS25040	COG1970	mechanosensitive ion channel activity
EPA93_RS25045	COG1193	negative regulation of DNA recombination
EPA93_RS25065	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EPA93_RS25070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EPA93_RS25085	COG2890	protein-(glutamine-N5) methyltransferase activity
EPA93_RS25100	COG2188	Transcriptional regulator
EPA93_RS25110	COG1653	transport
EPA93_RS25120	COG0395	ABC-type sugar transport system, permease component
EPA93_RS25125	COG1940	carbohydrate kinase activity
EPA93_RS25130	COG2719	SpoVR family
EPA93_RS25135	COG2718	Belongs to the UPF0229 family
EPA93_RS25165	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EPA93_RS25175	COG1131	(ABC) transporter
EPA93_RS25175	COG0842	Transport permease protein
EPA93_RS25175	COG1716	ATPase activity
EPA93_RS25185	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EPA93_RS25190	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EPA93_RS25205	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EPA93_RS25210	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EPA93_RS25215	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EPA93_RS25225	COG4585	Histidine kinase
EPA93_RS25235	COG1595	DNA-templated transcription, initiation
EPA93_RS25240	COG2226	methyltransferase
EPA93_RS25250	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EPA93_RS25265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPA93_RS25270	COG1957	nucleoside hydrolase
EPA93_RS25275	COG2151	metal-sulfur cluster biosynthetic enzyme
EPA93_RS25290	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EPA93_RS25315	COG1063	alcohol dehydrogenase
EPA93_RS25320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPA93_RS25325	COG0726	polysaccharide deacetylase
EPA93_RS25360	COG0003	Pfam Anion-transporting ATPase
EPA93_RS25385	COG1122	ATPase activity
EPA93_RS25390	COG1283	sodium-dependent phosphate transmembrane transporter activity
EPA93_RS25395	COG0640	Transcriptional regulator
EPA93_RS25400	COG0346	lactoylglutathione lyase activity
EPA93_RS25410	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EPA93_RS25420	COG0268	Binds directly to 16S ribosomal RNA
EPA93_RS25430	COG0626	cystathionine gamma-synthase activity
EPA93_RS25455	COG1024	Enoyl-CoA hydratase
EPA93_RS25500	COG2909	trisaccharide binding
EPA93_RS25540	COG2095	MarC family integral membrane protein
EPA93_RS25545	COG2261	transglycosylase associated protein
EPA93_RS25570	COG0805	protein transport
EPA93_RS25575	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EPA93_RS25590	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EPA93_RS25605	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EPA93_RS25610	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EPA93_RS25625	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EPA93_RS25650	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EPA93_RS25660	COG3118	belongs to the thioredoxin family
EPA93_RS25680	COG1132	(ABC) transporter
EPA93_RS25700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EPA93_RS25735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EPA93_RS25760	COG0515	serine threonine protein kinase
EPA93_RS25760	COG2815	serine threonine protein kinase
EPA93_RS25765	COG2815	serine threonine protein kinase
EPA93_RS25765	COG0515	serine threonine protein kinase
EPA93_RS25770	COG0515	serine threonine protein kinase
EPA93_RS25775	COG1007	ATP synthesis coupled electron transport
EPA93_RS25785	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EPA93_RS25790	COG0713	ATP synthesis coupled electron transport
EPA93_RS25795	COG0839	Belongs to the complex I subunit 6 family
EPA93_RS25805	COG0569	domain protein
EPA93_RS25810	COG0569	domain protein
EPA93_RS25815	COG0628	permease
EPA93_RS25840	COG3942	CHAP domain
EPA93_RS25850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPA93_RS25865	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EPA93_RS25880	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EPA93_RS25910	COG0387	Pfam Sodium calcium exchanger
EPA93_RS25915	COG2205	protein histidine kinase activity
EPA93_RS25920	COG2815	serine threonine protein kinase
EPA93_RS25920	COG0515	serine threonine protein kinase
EPA93_RS25925	COG2348	transferase activity, transferring amino-acyl groups
EPA93_RS25940	COG0739	heme binding
EPA93_RS25940	COG0741	lytic transglycosylase activity
EPA93_RS25940	COG1196	nuclear chromosome segregation
EPA93_RS25945	COG4191	Histidine kinase
EPA93_RS25965	COG0183	Belongs to the thiolase family
EPA93_RS25970	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EPA93_RS26000	COG0028	Belongs to the TPP enzyme family
EPA93_RS26000	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
EPA93_RS26025	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
EPA93_RS26080	COG0515	serine threonine protein kinase
EPA93_RS26080	COG2815	serine threonine protein kinase
EPA93_RS26085	COG0515	serine threonine protein kinase
EPA93_RS26085	COG2815	serine threonine protein kinase
EPA93_RS26090	COG2815	serine threonine protein kinase
EPA93_RS26090	COG0515	serine threonine protein kinase
EPA93_RS26095	COG0515	serine threonine protein kinase
EPA93_RS26095	COG2815	serine threonine protein kinase
EPA93_RS26100	COG2815	serine threonine protein kinase
EPA93_RS26100	COG0515	serine threonine protein kinase
EPA93_RS26115	COG1061	Type III restriction enzyme res subunit
EPA93_RS26130	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EPA93_RS26140	COG0571	ribonuclease III activity
EPA93_RS26155	COG2197	response regulator
EPA93_RS26160	COG4585	Histidine kinase
EPA93_RS26190	COG1131	(ABC) transporter
EPA93_RS26200	COG2815	serine threonine protein kinase
EPA93_RS26200	COG0515	serine threonine protein kinase
EPA93_RS26205	COG0515	serine threonine protein kinase
EPA93_RS26205	COG2815	serine threonine protein kinase
EPA93_RS26225	COG0412	Dienelactone hydrolase
EPA93_RS26230	COG0423	glycine-tRNA ligase activity
EPA93_RS26245	COG0604	alcohol dehydrogenase
EPA93_RS26265	COG0590	tRNA wobble adenosine to inosine editing
EPA93_RS26310	COG0484	heat shock protein binding
EPA93_RS26315	COG0443	Heat shock 70 kDa protein
EPA93_RS26320	COG1420	regulation of RNA biosynthetic process
EPA93_RS26325	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EPA93_RS26335	COG0758	DNA mediated transformation
EPA93_RS26370	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EPA93_RS26380	COG1597	lipid kinase activity
EPA93_RS26385	COG1160	GTP binding
EPA93_RS26390	COG0640	Transcriptional regulator
EPA93_RS26395	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS26400	COG0673	inositol 2-dehydrogenase activity
EPA93_RS26405	COG2197	response regulator
EPA93_RS26410	COG4585	Histidine kinase
EPA93_RS26420	COG1131	(ABC) transporter
EPA93_RS26430	COG0508	dehydrogenase complex catalyzes the overall conversion of
EPA93_RS26450	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EPA93_RS26455	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EPA93_RS26465	COG1309	transcriptional regulator
EPA93_RS26515	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EPA93_RS26530	COG3119	arylsulfatase activity
EPA93_RS26540	COG0395	ABC-type sugar transport system, permease component
EPA93_RS26545	COG4209	transmembrane transport
EPA93_RS26550	COG2909	trisaccharide binding
EPA93_RS26565	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EPA93_RS26590	COG1733	regulation of RNA biosynthetic process
EPA93_RS26615	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EPA93_RS26620	COG0840	transmembrane signaling receptor activity
EPA93_RS26630	COG0359	binds to the 23S rRNA
EPA93_RS26635	COG0387	Pfam Sodium calcium exchanger
EPA93_RS26640	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EPA93_RS26640	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EPA93_RS26650	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EPA93_RS26675	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EPA93_RS26705	COG2239	Acts as a magnesium transporter
EPA93_RS26715	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EPA93_RS26760	COG0288	reversible hydration of carbon dioxide
EPA93_RS26765	COG0473	3-isopropylmalate dehydrogenase activity
EPA93_RS26775	COG0704	Plays a role in the regulation of phosphate uptake
EPA93_RS26780	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EPA93_RS26795	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EPA93_RS26795	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EPA93_RS26800	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EPA93_RS26800	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EPA93_RS26810	COG1550	Protein conserved in bacteria
EPA93_RS26815	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EPA93_RS26860	COG3864	Putative metallopeptidase domain
EPA93_RS26865	COG0842	Transport permease protein
EPA93_RS26865	COG1131	(ABC) transporter
EPA93_RS26865	COG1716	ATPase activity
EPA93_RS26885	COG4221	oxidoreductase activity
EPA93_RS26905	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EPA93_RS26935	COG4977	sequence-specific DNA binding
EPA93_RS26955	COG1309	transcriptional regulator
EPA93_RS27015	COG5002	protein histidine kinase activity
EPA93_RS27020	COG0745	RESPONSE REGULATOR receiver
EPA93_RS27070	COG2814	Major facilitator Superfamily
EPA93_RS27075	COG0583	DNA-binding transcription factor activity
EPA93_RS27085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS27095	COG0583	DNA-binding transcription factor activity
EPA93_RS27125	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EPA93_RS27155	COG1187	pseudouridine synthase activity
EPA93_RS27170	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EPA93_RS27195	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EPA93_RS27200	COG1522	sequence-specific DNA binding
EPA93_RS27260	COG1595	DNA-templated transcription, initiation
EPA93_RS27280	COG1309	transcriptional regulator
EPA93_RS27285	COG2124	cytochrome p450
EPA93_RS27310	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
EPA93_RS27340	COG0583	DNA-binding transcription factor activity
EPA93_RS27345	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS27360	COG0300	oxidoreductase activity
EPA93_RS27370	COG0791	NLP P60 protein
EPA93_RS27410	COG2378	regulation of single-species biofilm formation
EPA93_RS27420	COG0583	DNA-binding transcription factor activity
EPA93_RS27455	COG0667	Aldo Keto reductase
EPA93_RS27460	COG0583	DNA-binding transcription factor activity
EPA93_RS27465	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EPA93_RS27470	COG0604	alcohol dehydrogenase
EPA93_RS27475	COG2353	YceI-like domain
EPA93_RS27515	COG2226	methyltransferase
EPA93_RS27570	COG0681	Belongs to the peptidase S26 family
EPA93_RS27585	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EPA93_RS27595	COG0138	bifunctional purine biosynthesis protein purh
EPA93_RS27610	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EPA93_RS27610	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EPA93_RS27625	COG1012	belongs to the aldehyde dehydrogenase family
EPA93_RS27635	COG1442	glycosyl transferase family 8
EPA93_RS27635	COG1216	Glycosyl transferase, family 2
EPA93_RS27650	COG1733	regulation of RNA biosynthetic process
EPA93_RS27660	COG2353	YceI-like domain
EPA93_RS27700	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EPA93_RS27705	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EPA93_RS27720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPA93_RS27750	COG3548	integral membrane protein
EPA93_RS27755	COG0596	Alpha beta hydrolase
EPA93_RS27760	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS27760	COG3321	synthase
EPA93_RS27760	COG0604	alcohol dehydrogenase
EPA93_RS27780	COG0546	phosphoglycolate phosphatase activity
EPA93_RS27785	COG0187	DNA topoisomerase II activity
EPA93_RS27800	COG1473	amidohydrolase
EPA93_RS27835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS27850	COG2080	2 iron, 2 sulfur cluster binding
EPA93_RS27855	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
EPA93_RS27860	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EPA93_RS27870	COG0084	hydrolase, TatD family'
EPA93_RS27875	COG0215	cysteine-tRNA ligase activity
EPA93_RS27895	COG2003	Belongs to the UPF0758 family
EPA93_RS27910	COG1899	peptidyl-lysine modification to peptidyl-hypusine
EPA93_RS27915	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EPA93_RS27945	COG1575	Belongs to the MenA family. Type 1 subfamily
EPA93_RS27955	COG0515	serine threonine protein kinase
EPA93_RS27955	COG2815	serine threonine protein kinase
EPA93_RS27975	COG0023	Translation Initiation Factor
EPA93_RS27990	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EPA93_RS27995	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EPA93_RS28000	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EPA93_RS28005	COG1309	transcriptional regulator
EPA93_RS28015	COG1216	Glycosyl transferase, family 2
EPA93_RS28035	COG1595	DNA-templated transcription, initiation
EPA93_RS28040	COG0628	permease
EPA93_RS28075	COG1396	sequence-specific DNA binding
EPA93_RS28100	COG0039	L-malate dehydrogenase activity
EPA93_RS28125	COG0315	cyclic pyranopterin monophosphate synthase activity
EPA93_RS28135	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EPA93_RS28140	COG0768	penicillin binding
EPA93_RS28145	COG2135	peptidase activity
EPA93_RS28150	COG1268	BioY protein
EPA93_RS28155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EPA93_RS28165	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EPA93_RS28195	COG1733	regulation of RNA biosynthetic process
EPA93_RS28205	COG1113	amino acid transport
EPA93_RS28220	COG1309	transcriptional regulator
EPA93_RS28240	COG0515	serine threonine protein kinase
EPA93_RS28240	COG2815	serine threonine protein kinase
EPA93_RS28250	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EPA93_RS28360	COG0655	NAD(P)H dehydrogenase (quinone) activity
EPA93_RS28365	COG0662	Cupin 2, conserved barrel domain protein
EPA93_RS28375	COG4257	antibiotic catabolic process
EPA93_RS28380	COG0667	Aldo Keto reductase
EPA93_RS28390	COG0667	Aldo Keto reductase
EPA93_RS28395	COG1522	sequence-specific DNA binding
EPA93_RS28405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS28445	COG0723	plastoquinol--plastocyanin reductase activity
EPA93_RS28465	COG2009	succinate dehydrogenase
EPA93_RS28480	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EPA93_RS28495	COG2132	Multicopper oxidase
EPA93_RS28500	COG0596	Alpha beta hydrolase
EPA93_RS28520	COG2814	Major facilitator Superfamily
EPA93_RS28525	COG1309	transcriptional regulator
EPA93_RS28535	COG0506	proline dehydrogenase activity
EPA93_RS28540	COG1132	(ABC) transporter
EPA93_RS28545	COG1132	(ABC) transporter
EPA93_RS28565	COG2205	protein histidine kinase activity
EPA93_RS28585	COG2378	regulation of single-species biofilm formation
EPA93_RS28610	COG0367	asparagine synthase
EPA93_RS28620	COG1024	Enoyl-CoA hydratase
EPA93_RS28625	COG1024	Enoyl-CoA hydratase
EPA93_RS28645	COG2151	metal-sulfur cluster biosynthetic enzyme
EPA93_RS28700	COG0542	response to heat
EPA93_RS28710	COG1309	transcriptional regulator
EPA93_RS28740	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EPA93_RS28760	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EPA93_RS28765	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EPA93_RS28770	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EPA93_RS28775	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EPA93_RS28780	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EPA93_RS28785	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EPA93_RS28795	COG0356	it plays a direct role in the translocation of protons across the membrane
EPA93_RS28815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EPA93_RS28840	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EPA93_RS28860	COG0477	Major facilitator Superfamily
EPA93_RS28870	COG1307	EDD domain protein, DegV family
EPA93_RS28875	COG1461	Dihydroxyacetone kinase
EPA93_RS28880	COG1302	Protein conserved in bacteria
EPA93_RS28885	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EPA93_RS28890	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EPA93_RS28910	COG1695	Transcriptional regulator
EPA93_RS28915	COG0631	protein serine/threonine phosphatase activity
EPA93_RS28930	COG0025	NhaP-type Na H and K H
EPA93_RS28935	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EPA93_RS28950	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EPA93_RS28960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS29045	COG0318	PFAM AMP-dependent synthetase and ligase
EPA93_RS29050	COG1960	acyl-CoA dehydrogenase activity
EPA93_RS29055	COG0183	Belongs to the thiolase family
EPA93_RS29060	COG1024	Enoyl-CoA hydratase
EPA93_RS29060	COG1250	3-hydroxyacyl-CoA dehydrogenase
EPA93_RS29065	COG3842	ATPase activity
EPA93_RS29115	COG0745	RESPONSE REGULATOR receiver
EPA93_RS29120	COG0295	cytidine deaminase activity
EPA93_RS29125	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
EPA93_RS29145	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EPA93_RS29150	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EPA93_RS29155	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EPA93_RS29185	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EPA93_RS29195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPA93_RS29205	COG0736	holo-[acyl-carrier-protein] synthase activity
EPA93_RS29210	COG1490	D-aminoacyl-tRNA deacylase activity
EPA93_RS29215	COG1522	sequence-specific DNA binding
EPA93_RS29220	COG3483	tryptophan 2,3-dioxygenase activity
EPA93_RS29235	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EPA93_RS29240	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EPA93_RS29245	COG1846	Transcriptional regulator
EPA93_RS29255	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS29260	COG5635	Nacht domain
EPA93_RS29260	COG2319	Wd-40 repeat
EPA93_RS29265	COG2226	methyltransferase
EPA93_RS29270	COG2226	methyltransferase
EPA93_RS29275	COG2226	methyltransferase
EPA93_RS29280	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EPA93_RS29290	COG2226	methyltransferase
EPA93_RS29295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPA93_RS29300	COG1595	DNA-templated transcription, initiation
EPA93_RS29310	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EPA93_RS29330	COG0724	RNA recognition motif
EPA93_RS29355	COG1309	transcriptional regulator
EPA93_RS29360	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
EPA93_RS29370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPA93_RS29380	COG0312	modulator of DNA gyrase
EPA93_RS29395	COG1695	Transcriptional regulator
EPA93_RS29405	COG2226	methyltransferase
EPA93_RS29450	COG3655	Transcriptional regulator
EPA93_RS29470	COG0477	Major facilitator Superfamily
EPA93_RS29475	COG1566	PFAM secretion protein HlyD family protein
EPA93_RS29485	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EPA93_RS29520	COG3548	integral membrane protein
EPA93_RS29530	COG0438	transferase activity, transferring glycosyl groups
EPA93_RS29535	COG1846	Transcriptional regulator
EPA93_RS29595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EPA93_RS29605	COG0671	phosphoesterase, PA-phosphatase related
EPA93_RS29615	COG2890	protein-(glutamine-N5) methyltransferase activity
EPA93_RS29625	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EPA93_RS29635	COG2815	serine threonine protein kinase
EPA93_RS29635	COG0515	serine threonine protein kinase
EPA93_RS29680	COG0322	excinuclease ABC activity
EPA93_RS29695	COG2205	protein histidine kinase activity
EPA93_RS29710	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS29725	COG0747	negative chemotaxis
EPA93_RS29740	COG0174	glutamine synthetase
EPA93_RS29750	COG0612	Peptidase, M16
EPA93_RS29755	COG4636	protein conserved in cyanobacteria
EPA93_RS29775	COG1968	undecaprenyl-diphosphatase activity
EPA93_RS29780	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EPA93_RS29785	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EPA93_RS29800	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EPA93_RS29825	COG5002	protein histidine kinase activity
EPA93_RS29830	COG0742	ribosomal rna small subunit methyltransferase
EPA93_RS29845	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EPA93_RS29855	COG1316	TRANSCRIPTIONal
EPA93_RS29865	COG0515	serine threonine protein kinase
EPA93_RS29865	COG2815	serine threonine protein kinase
EPA93_RS29870	COG0251	oxidation-reduction process
EPA93_RS29875	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EPA93_RS29885	COG0647	UMP catabolic process
EPA93_RS29900	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EPA93_RS29955	COG1216	Glycosyl transferase, family 2
EPA93_RS29965	COG4585	Histidine kinase
EPA93_RS29970	COG2197	response regulator
EPA93_RS29995	COG0459	protein refolding
EPA93_RS30000	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EPA93_RS30015	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EPA93_RS30030	COG2378	regulation of single-species biofilm formation
EPA93_RS30035	COG0745	RESPONSE REGULATOR receiver
EPA93_RS30040	COG0745	RESPONSE REGULATOR receiver
EPA93_RS30050	COG0114	fumarate hydratase activity
EPA93_RS30065	COG0017	Asparaginyl-tRNA synthetase
EPA93_RS30085	COG2815	serine threonine protein kinase
EPA93_RS30085	COG0515	serine threonine protein kinase
EPA93_RS30125	COG3842	ATPase activity
EPA93_RS30130	COG1733	regulation of RNA biosynthetic process
EPA93_RS30140	COG0745	RESPONSE REGULATOR receiver
EPA93_RS30145	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EPA93_RS30155	COG0581	inorganic phosphate transmembrane transporter activity
EPA93_RS30160	COG0573	inorganic phosphate transmembrane transporter activity
EPA93_RS30165	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EPA93_RS30180	COG0521	Mo-molybdopterin cofactor biosynthetic process
EPA93_RS30195	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EPA93_RS30230	COG2272	Belongs to the type-B carboxylesterase lipase family
EPA93_RS30240	COG2813	Specifically methylates the guanine in position
EPA93_RS30245	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EPA93_RS30250	COG0745	RESPONSE REGULATOR receiver
EPA93_RS30255	COG3903	Transcriptional regulator
EPA93_RS30255	COG3629	intracellular signal transduction
EPA93_RS30260	COG0617	tRNA 3'-terminal CCA addition
EPA93_RS30270	COG1172	Belongs to the binding-protein-dependent transport system permease family
EPA93_RS30275	COG1172	Belongs to the binding-protein-dependent transport system permease family
EPA93_RS30280	COG1129	ABC transporter
EPA93_RS30285	COG1879	ABC-type sugar transport system periplasmic component
EPA93_RS30295	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EPA93_RS30300	COG1674	ftsk spoiiie
EPA93_RS30330	COG0745	RESPONSE REGULATOR receiver
EPA93_RS30365	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EPA93_RS30370	COG0842	Transport permease protein
EPA93_RS30370	COG1131	(ABC) transporter
EPA93_RS30370	COG1716	ATPase activity
EPA93_RS30395	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EPA93_RS30405	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EPA93_RS30410	COG0484	heat shock protein binding
EPA93_RS30415	COG0789	Transcriptional regulator
EPA93_RS30420	COG2909	trisaccharide binding
EPA93_RS30430	COG1472	Belongs to the glycosyl hydrolase 3 family
EPA93_RS30435	COG1522	sequence-specific DNA binding
EPA93_RS30445	COG1063	alcohol dehydrogenase
EPA93_RS30450	COG2205	protein histidine kinase activity
EPA93_RS30455	COG0745	RESPONSE REGULATOR receiver
EPA93_RS30460	COG1609	Transcriptional regulator
EPA93_RS30465	COG0747	negative chemotaxis
EPA93_RS30470	COG0601	transmembrane transport
EPA93_RS30475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPA93_RS30495	COG1959	2 iron, 2 sulfur cluster binding
EPA93_RS30520	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EPA93_RS30525	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EPA93_RS30535	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EPA93_RS30540	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EPA93_RS30545	COG0051	transcription antitermination factor activity, RNA binding
EPA93_RS30550	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EPA93_RS30555	COG0088	Forms part of the polypeptide exit tunnel
EPA93_RS30560	COG0089	rRNA binding
EPA93_RS30565	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EPA93_RS30570	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EPA93_RS30575	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EPA93_RS30580	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EPA93_RS30595	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EPA93_RS30600	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EPA93_RS30605	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EPA93_RS30610	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EPA93_RS30615	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EPA93_RS30620	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EPA93_RS30625	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EPA93_RS30635	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EPA93_RS30640	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EPA93_RS30650	COG0200	Binds to the 23S rRNA
EPA93_RS30655	COG0201	protein transport
EPA93_RS30660	COG0563	adenylate kinase activity
EPA93_RS30665	COG0024	Methionine aminopeptidase
EPA93_RS30670	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EPA93_RS30675	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EPA93_RS30680	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EPA93_RS30685	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EPA93_RS30690	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EPA93_RS30695	COG0202	RNA polymerase activity
EPA93_RS30700	COG0203	ribosomal protein L17
EPA93_RS30705	COG0101	tRNA pseudouridine synthase activity
EPA93_RS30710	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EPA93_RS30715	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EPA93_RS30725	COG0300	oxidoreductase activity
EPA93_RS30735	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
EPA93_RS30740	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EPA93_RS30745	COG0010	Belongs to the arginase family
EPA93_RS30750	COG4166	transmembrane transport
EPA93_RS30755	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EPA93_RS30760	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EPA93_RS30760	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EPA93_RS30765	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EPA93_RS30770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EPA93_RS30775	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EPA93_RS30785	COG0360	Binds together with S18 to 16S ribosomal RNA
EPA93_RS30795	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EPA93_RS30800	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EPA93_RS30805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EPA93_RS30815	COG0840	transmembrane signaling receptor activity
EPA93_RS30820	COG0439	Biotin carboxylase
EPA93_RS30825	COG0681	Belongs to the peptidase S26 family
EPA93_RS30830	COG0613	PHP domain protein
EPA93_RS30835	COG1418	mRNA catabolic process
EPA93_RS30850	COG0183	Belongs to the thiolase family
EPA93_RS30865	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EPA93_RS30870	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EPA93_RS30880	COG2814	Major facilitator Superfamily
EPA93_RS30885	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
EPA93_RS30885	COG3608	succinylglutamate desuccinylase aspartoacylase
EPA93_RS30900	COG2267	carboxylic ester hydrolase activity
EPA93_RS30905	COG0148	phosphopyruvate hydratase activity
EPA93_RS30915	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EPA93_RS31035	COG1007	ATP synthesis coupled electron transport
EPA93_RS31050	COG0713	ATP synthesis coupled electron transport
EPA93_RS31055	COG0839	Belongs to the complex I subunit 6 family
EPA93_RS31060	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EPA93_RS31065	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EPA93_RS31070	COG1034	ATP synthesis coupled electron transport
EPA93_RS31085	COG0649	NAD binding
EPA93_RS31095	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EPA93_RS31100	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EPA93_RS31110	COG2807	transmembrane transport
EPA93_RS31115	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EPA93_RS31175	COG3559	Exporter of polyketide antibiotics
EPA93_RS31180	COG1131	(ABC) transporter
EPA93_RS31185	COG1309	transcriptional regulator
EPA93_RS31190	COG0277	FAD linked oxidase domain protein
EPA93_RS31215	COG0667	Aldo Keto reductase
EPA93_RS31225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS31250	COG0515	serine threonine protein kinase
EPA93_RS31250	COG2815	serine threonine protein kinase
EPA93_RS31255	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EPA93_RS31270	COG2271	Major facilitator Superfamily
EPA93_RS31280	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EPA93_RS31285	COG1309	transcriptional regulator
EPA93_RS31290	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS31295	COG2197	response regulator
EPA93_RS31320	COG4106	trans-aconitate 2-methyltransferase activity
EPA93_RS31325	COG1725	Transcriptional regulator
EPA93_RS31345	COG0242	peptide deformylase activity
EPA93_RS31355	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EPA93_RS31360	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EPA93_RS31375	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EPA93_RS31385	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EPA93_RS31390	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EPA93_RS31395	COG0151	Belongs to the GarS family
EPA93_RS31400	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EPA93_RS31405	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EPA93_RS31455	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EPA93_RS31460	COG2195	Cleaves the N-terminal amino acid of tripeptides
EPA93_RS31465	COG0436	Aminotransferase
EPA93_RS31485	COG2226	methyltransferase
EPA93_RS31510	COG2378	regulation of single-species biofilm formation
EPA93_RS31555	COG2814	Major facilitator Superfamily
EPA93_RS31590	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EPA93_RS31595	COG0544	peptidyl-prolyl cis-trans isomerase activity
EPA93_RS31610	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EPA93_RS31625	COG0596	Alpha beta hydrolase
EPA93_RS31660	COG1309	transcriptional regulator
EPA93_RS31685	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EPA93_RS31710	COG0251	oxidation-reduction process
EPA93_RS31720	COG0667	Aldo Keto reductase
EPA93_RS31755	COG1733	regulation of RNA biosynthetic process
EPA93_RS31790	COG1162	GTPase activity
EPA93_RS31795	COG1921	L-seryl-tRNASec selenium transferase activity
EPA93_RS31820	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EPA93_RS31825	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EPA93_RS31835	COG0250	Participates in transcription elongation, termination and antitermination
EPA93_RS31845	COG0081	regulation of translation
EPA93_RS31850	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EPA93_RS31855	COG0222	ribosome binding
EPA93_RS31860	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EPA93_RS31865	COG1185	polyribonucleotide nucleotidyltransferase activity
EPA93_RS31870	COG1573	uracil-dna glycosylase
EPA93_RS31880	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EPA93_RS31890	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EPA93_RS31920	COG2272	Belongs to the type-B carboxylesterase lipase family
EPA93_RS31930	COG1505	serine-type exopeptidase activity
EPA93_RS31950	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EPA93_RS31955	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EPA93_RS31995	COG0358	DNA primase activity
EPA93_RS32000	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EPA93_RS32005	COG0149	triose-phosphate isomerase activity
EPA93_RS32010	COG0126	phosphoglycerate kinase activity
EPA93_RS32025	COG0730	response to heat
EPA93_RS32050	COG2909	trisaccharide binding
EPA93_RS32075	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS32100	COG1228	amidohydrolase
EPA93_RS32110	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS32120	COG2909	trisaccharide binding
EPA93_RS32130	COG0384	phenazine biosynthesis protein PhzF
EPA93_RS32140	COG2140	Oxalate decarboxylase
EPA93_RS32145	COG1063	alcohol dehydrogenase
EPA93_RS32165	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EPA93_RS32175	COG2197	response regulator
EPA93_RS32200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPA93_RS32245	COG0861	Integral membrane protein TerC family
EPA93_RS32270	COG0187	DNA topoisomerase II activity
EPA93_RS32280	COG0383	alpha-mannosidase activity
EPA93_RS32290	COG2197	response regulator
EPA93_RS32300	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EPA93_RS32305	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EPA93_RS32315	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS32345	COG0673	inositol 2-dehydrogenase activity
EPA93_RS32360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPA93_RS32375	COG0318	PFAM AMP-dependent synthetase and ligase
EPA93_RS32380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPA93_RS32385	COG2084	Dehydrogenase
EPA93_RS32390	COG0596	Alpha beta hydrolase
EPA93_RS32390	COG0508	dehydrogenase complex catalyzes the overall conversion of
EPA93_RS32405	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EPA93_RS32410	COG2255	four-way junction helicase activity
EPA93_RS32435	COG2204	response regulator
EPA93_RS32455	COG5433	transposase activity
EPA93_RS32555	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EPA93_RS32565	COG0596	Alpha beta hydrolase
EPA93_RS32650	COG1744	ABC transporter substrate-binding protein PnrA-like
EPA93_RS32675	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EPA93_RS32705	COG5002	protein histidine kinase activity
EPA93_RS32710	COG0745	RESPONSE REGULATOR receiver
EPA93_RS32725	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
EPA93_RS32730	COG1940	carbohydrate kinase activity
EPA93_RS32745	COG0612	Peptidase, M16
EPA93_RS32760	COG0745	RESPONSE REGULATOR receiver
EPA93_RS32795	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EPA93_RS32805	COG2226	methyltransferase
EPA93_RS32835	COG0604	alcohol dehydrogenase
EPA93_RS32845	COG2378	regulation of single-species biofilm formation
EPA93_RS32865	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EPA93_RS32880	COG2239	Acts as a magnesium transporter
EPA93_RS32910	COG0596	Alpha beta hydrolase
EPA93_RS32915	COG1247	-acetyltransferase
EPA93_RS32920	COG5002	protein histidine kinase activity
EPA93_RS32950	COG2201	protein-glutamate methylesterase activity
EPA93_RS32955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EPA93_RS32960	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EPA93_RS32975	COG2124	cytochrome p450
EPA93_RS32985	COG0519	Catalyzes the synthesis of GMP from XMP
EPA93_RS32985	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EPA93_RS32995	COG4636	protein conserved in cyanobacteria
EPA93_RS33010	COG4636	protein conserved in cyanobacteria
EPA93_RS33015	COG0582	viral genome integration into host DNA
EPA93_RS33050	COG0439	Biotin carboxylase
EPA93_RS33055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EPA93_RS33060	COG0511	ligase activity, forming carbon-carbon bonds
EPA93_RS33090	COG3854	ATPases associated with a variety of cellular activities
EPA93_RS33100	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
EPA93_RS33105	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
EPA93_RS33110	COG3842	ATPase activity
EPA93_RS33125	COG0318	PFAM AMP-dependent synthetase and ligase
EPA93_RS33140	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS33145	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPA93_RS33155	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EPA93_RS33160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EPA93_RS33170	COG1105	Belongs to the carbohydrate kinase PfkB family
EPA93_RS33175	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EPA93_RS33180	COG0673	inositol 2-dehydrogenase activity
EPA93_RS33185	COG0395	ABC-type sugar transport system, permease component
EPA93_RS33190	COG1175	transmembrane transport
EPA93_RS33200	COG1349	DNA-binding transcription factor activity
EPA93_RS33215	COG0174	glutamine synthetase
EPA93_RS33240	COG1566	PFAM secretion protein HlyD family protein
EPA93_RS33315	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EPA93_RS33330	COG0420	3'-5' exonuclease activity
EPA93_RS33335	COG1473	amidohydrolase
EPA93_RS33340	COG0697	spore germination
EPA93_RS33355	COG0012	GTP binding
EPA93_RS33375	COG1192	Involved in chromosome partitioning
EPA93_RS33380	COG1475	DNA binding
EPA93_RS33390	COG1418	mRNA catabolic process
EPA93_RS33395	COG2197	response regulator
EPA93_RS33400	COG4585	Histidine kinase
EPA93_RS33405	COG2203	Gaf domain
EPA93_RS33405	COG4585	Histidine kinase
EPA93_RS33410	COG2197	response regulator
EPA93_RS33455	COG0154	amidase activity
EPA93_RS33460	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EPA93_RS33465	COG2201	protein-glutamate methylesterase activity
EPA93_RS33480	COG0582	viral genome integration into host DNA
EPA93_RS33515	COG2211	Major facilitator Superfamily
EPA93_RS33550	COG2197	response regulator
EPA93_RS33560	COG0535	radical SAM domain protein
EPA93_RS33575	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EPA93_RS33580	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EPA93_RS33650	COG2814	Major facilitator Superfamily
EPA93_RS33665	COG2226	methyltransferase
EPA93_RS33675	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EPA93_RS33680	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EPA93_RS33685	COG0509	glycine decarboxylation via glycine cleavage system
EPA93_RS33710	COG5433	transposase activity
EPA93_RS33715	COG1847	R3H domain protein
EPA93_RS33720	COG0706	membrane insertase activity
EPA93_RS33725	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EPA93_RS33730	COG0594	ribonuclease P activity
EPA93_RS33735	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EPA93_RS33750	COG0631	protein serine/threonine phosphatase activity
EPA93_RS33755	COG0515	serine threonine protein kinase
EPA93_RS33755	COG2815	serine threonine protein kinase
EPA93_RS33760	COG0631	protein serine/threonine phosphatase activity
EPA93_RS33765	COG1160	GTP binding
EPA93_RS33770	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EPA93_RS33800	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS33805	COG0822	iron-sulfur transferase activity
EPA93_RS33810	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EPA93_RS33815	COG0719	Fe-S assembly protein
EPA93_RS33820	COG0396	ATPase activity
EPA93_RS33825	COG1959	2 iron, 2 sulfur cluster binding
EPA93_RS33840	COG4585	Histidine kinase
EPA93_RS33845	COG2197	response regulator
EPA93_RS33850	COG0657	acetylesterase activity
EPA93_RS33855	COG1136	(ABC) transporter
EPA93_RS33860	COG1136	(ABC) transporter
EPA93_RS33860	COG0577	efflux transmembrane transporter activity
EPA93_RS33890	COG0604	alcohol dehydrogenase
EPA93_RS33895	COG0477	Major facilitator Superfamily
EPA93_RS33905	COG4603	Belongs to the binding-protein-dependent transport system permease family
EPA93_RS33910	COG1079	Belongs to the binding-protein-dependent transport system permease family
EPA93_RS33915	COG3845	ABC transporter
EPA93_RS33925	COG0076	glutamate decarboxylase activity
EPA93_RS33970	COG0456	acetyltransferase
EPA93_RS34010	COG0539	negative regulation of cytoplasmic translation
EPA93_RS34030	COG0596	Alpha beta hydrolase
EPA93_RS34050	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EPA93_RS34060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EPA93_RS34065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EPA93_RS34090	COG2264	protein methyltransferase activity
EPA93_RS34100	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EPA93_RS34105	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EPA93_RS34150	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EPA93_RS34160	COG0789	Transcriptional regulator
EPA93_RS34180	COG1309	transcriptional regulator
EPA93_RS34190	COG2197	response regulator
EPA93_RS34195	COG4585	Histidine kinase
EPA93_RS34215	COG1535	isochorismatase
EPA93_RS34215	COG3433	isochorismatase activity
EPA93_RS34225	COG1733	regulation of RNA biosynthetic process
EPA93_RS34250	COG0531	amino acid
EPA93_RS34270	COG0693	protein deglycase activity
EPA93_RS34285	COG4585	Histidine kinase
EPA93_RS34290	COG2197	response regulator
EPA93_RS34295	COG0640	Transcriptional regulator
EPA93_RS34330	COG0702	epimerase
EPA93_RS34335	COG4948	Mandelate Racemase Muconate Lactonizing
EPA93_RS34340	COG4166	transmembrane transport
EPA93_RS34350	COG0747	negative chemotaxis
EPA93_RS34370	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EPA93_RS34380	COG0515	serine threonine protein kinase
EPA93_RS34445	COG0411	ABC transporter
EPA93_RS34455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS34470	COG3119	arylsulfatase activity
EPA93_RS34510	COG4585	Histidine kinase
EPA93_RS34515	COG2197	response regulator
EPA93_RS34535	COG1595	DNA-templated transcription, initiation
EPA93_RS34550	COG2508	Transcriptional regulator
EPA93_RS34565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPA93_RS34630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EPA93_RS34645	COG2197	response regulator
EPA93_RS34665	COG0596	Alpha beta hydrolase
EPA93_RS34680	COG2814	Major facilitator Superfamily
EPA93_RS34710	COG0789	Transcriptional regulator
EPA93_RS34710	COG4978	Transcriptional regulator
EPA93_RS34725	COG1846	Transcriptional regulator
EPA93_RS34735	COG2124	cytochrome p450
EPA93_RS34765	COG0745	RESPONSE REGULATOR receiver
EPA93_RS34855	COG0850	regulation of cytokinetic process
EPA93_RS34860	COG2894	cell division
EPA93_RS34865	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EPA93_RS34875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPA93_RS34880	COG0300	oxidoreductase activity
EPA93_RS34885	COG0789	Transcriptional regulator
EPA93_RS34895	COG0179	Fumarylacetoacetate (FAA) hydrolase
EPA93_RS34900	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EPA93_RS34905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPA93_RS34910	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EPA93_RS34945	COG0305	Participates in initiation and elongation during chromosome replication
EPA93_RS34945	COG1372	Participates in initiation and elongation during chromosome replication
EPA93_RS34960	COG0740	serine-type endopeptidase activity
EPA93_RS34965	COG1011	Hydrolase
EPA93_RS34970	COG2226	methyltransferase
EPA93_RS34990	COG0525	valine-tRNA ligase activity
EPA93_RS35000	COG2409	Drug exporters of the RND superfamily
EPA93_RS35005	COG0640	Transcriptional regulator
EPA93_RS35010	COG1132	(ABC) transporter
EPA93_RS35050	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EPA93_RS35055	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EPA93_RS35060	COG1666	GTP binding
EPA93_RS35075	COG2348	transferase activity, transferring amino-acyl groups
EPA93_RS35080	COG2348	transferase activity, transferring amino-acyl groups
EPA93_RS35085	COG0519	Catalyzes the synthesis of GMP from XMP
EPA93_RS35100	COG0789	Transcriptional regulator
EPA93_RS35160	COG2814	Major facilitator Superfamily
EPA93_RS35170	COG1522	sequence-specific DNA binding
EPA93_RS35185	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EPA93_RS35200	COG1940	carbohydrate kinase activity
EPA93_RS35230	COG0028	Belongs to the TPP enzyme family
EPA93_RS35235	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EPA93_RS35250	COG0709	Synthesizes selenophosphate from selenide and ATP
EPA93_RS35255	COG1660	Displays ATPase and GTPase activities
EPA93_RS35260	COG0667	Aldo Keto reductase
EPA93_RS35280	COG0747	negative chemotaxis
EPA93_RS35290	COG0515	serine threonine protein kinase
EPA93_RS35290	COG2815	serine threonine protein kinase
EPA93_RS35295	COG2815	serine threonine protein kinase
EPA93_RS35295	COG0515	serine threonine protein kinase
EPA93_RS35315	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EPA93_RS35320	COG1598	PFAM Uncharacterised protein family UPF0150
EPA93_RS35330	COG1131	(ABC) transporter
EPA93_RS35345	COG0745	RESPONSE REGULATOR receiver
EPA93_RS35350	COG5002	protein histidine kinase activity
EPA93_RS35350	COG3850	Histidine kinase
EPA93_RS35365	COG0583	DNA-binding transcription factor activity
EPA93_RS35390	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EPA93_RS35395	COG4585	Histidine kinase
EPA93_RS35400	COG2197	response regulator
EPA93_RS35420	COG2059	Chromate
EPA93_RS35425	COG0372	Belongs to the citrate synthase family
EPA93_RS35445	COG0714	Associated with various cellular activities
EPA93_RS35480	COG0640	Transcriptional regulator
EPA93_RS35490	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EPA93_RS35505	COG1309	transcriptional regulator
EPA93_RS35530	COG0789	Transcriptional regulator
EPA93_RS35530	COG4978	Transcriptional regulator
EPA93_RS35535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS35550	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EPA93_RS35560	COG2079	MmgE PrpD family protein
EPA93_RS35575	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EPA93_RS35580	COG1522	sequence-specific DNA binding
EPA93_RS35635	COG4106	trans-aconitate 2-methyltransferase activity
EPA93_RS35640	COG2815	serine threonine protein kinase
EPA93_RS35640	COG0515	serine threonine protein kinase
EPA93_RS35670	COG1653	transport
EPA93_RS35685	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EPA93_RS35690	COG0592	DNA-directed DNA polymerase activity
EPA93_RS35700	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EPA93_RS35705	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EPA93_RS35715	COG0583	DNA-binding transcription factor activity
EPA93_RS35725	COG2909	trisaccharide binding
EPA93_RS35730	COG2909	trisaccharide binding
EPA93_RS35735	COG0477	Major facilitator Superfamily
EPA93_RS35755	COG0138	bifunctional purine biosynthesis protein purh
EPA93_RS35765	COG2313	pseudouridylate synthase activity
EPA93_RS35775	COG1960	acyl-CoA dehydrogenase activity
EPA93_RS35780	COG2815	serine threonine protein kinase
EPA93_RS35780	COG0515	serine threonine protein kinase
EPA93_RS35785	COG0515	serine threonine protein kinase
EPA93_RS35785	COG2815	serine threonine protein kinase
EPA93_RS35790	COG0745	RESPONSE REGULATOR receiver
EPA93_RS35795	COG0416	fatty acid biosynthetic process
EPA93_RS35810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS35840	COG0438	transferase activity, transferring glycosyl groups
EPA93_RS35845	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EPA93_RS35850	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EPA93_RS35850	COG1796	DNA polymerase
EPA93_RS35860	COG3956	TIGRFAM MazG family protein
EPA93_RS35880	COG1774	PSP1 C-terminal conserved region
EPA93_RS35890	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EPA93_RS35910	COG2076	Multidrug Resistance protein
EPA93_RS35940	COG3842	ATPase activity
EPA93_RS35945	COG5000	phosphorelay sensor kinase activity
EPA93_RS35945	COG3279	Response regulator of the LytR AlgR family
EPA93_RS35955	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EPA93_RS35960	COG0542	response to heat
EPA93_RS35965	COG1063	alcohol dehydrogenase
EPA93_RS35990	COG0095	Lipoate-protein ligase
EPA93_RS35995	COG0343	queuine tRNA-ribosyltransferase activity
EPA93_RS36010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPA93_RS36035	COG0477	Major facilitator Superfamily
EPA93_RS36045	COG0596	Alpha beta hydrolase
EPA93_RS36085	COG1618	nucleotide phosphatase activity, acting on free nucleotides
EPA93_RS36095	COG0076	glutamate decarboxylase activity
EPA93_RS36120	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS36135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS36150	COG1280	lysine exporter protein (LysE YggA)
EPA93_RS36155	COG2072	flavoprotein involved in K transport
EPA93_RS36165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS36195	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EPA93_RS36205	COG2124	cytochrome p450
EPA93_RS36250	COG1595	DNA-templated transcription, initiation
EPA93_RS36320	COG2226	methyltransferase
EPA93_RS36330	COG0528	UMP kinase activity
EPA93_RS36335	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
EPA93_RS36360	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EPA93_RS36380	COG0484	heat shock protein binding
EPA93_RS36385	COG0024	Methionine aminopeptidase
EPA93_RS36395	COG1228	amidohydrolase
EPA93_RS36410	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
EPA93_RS36415	COG0508	dehydrogenase complex catalyzes the overall conversion of
EPA93_RS36420	COG0022	dehydrogenase e1 component
EPA93_RS36425	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EPA93_RS36440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPA93_RS36465	COG1595	DNA-templated transcription, initiation
EPA93_RS36505	COG1131	(ABC) transporter
EPA93_RS36510	COG1725	Transcriptional regulator
EPA93_RS36515	COG2001	Belongs to the MraZ family
EPA93_RS36520	COG0275	rRNA processing
EPA93_RS36530	COG0768	penicillin binding
EPA93_RS36540	COG0772	Belongs to the SEDS family
EPA93_RS36545	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EPA93_RS36550	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EPA93_RS36555	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EPA93_RS36560	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EPA93_RS36570	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EPA93_RS36595	COG0109	protoheme IX farnesyltransferase activity
EPA93_RS36595	COG1612	heme a metabolic process
EPA93_RS36600	COG3336	cytochrome c oxidase
EPA93_RS36610	COG2010	Cytochrome c
EPA93_RS36610	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EPA93_RS36625	COG1845	cytochrome c oxidase, subunit III
EPA93_RS36660	COG0789	Transcriptional regulator
EPA93_RS36660	COG4978	Transcriptional regulator
EPA93_RS36665	COG0745	RESPONSE REGULATOR receiver
EPA93_RS36685	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EPA93_RS36690	COG1138	Cytochrome C-type biogenesis protein
EPA93_RS36695	COG3088	subunit of a heme lyase
EPA93_RS36710	COG1131	(ABC) transporter
EPA93_RS36720	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EPA93_RS36770	COG0596	Alpha beta hydrolase
EPA93_RS36790	COG1733	regulation of RNA biosynthetic process
EPA93_RS36795	COG2249	NAD(P)H dehydrogenase (quinone) activity
EPA93_RS36805	COG1653	transport
EPA93_RS36810	COG3629	intracellular signal transduction
EPA93_RS36810	COG3903	Transcriptional regulator
EPA93_RS36840	COG4636	protein conserved in cyanobacteria
EPA93_RS36845	COG2815	serine threonine protein kinase
EPA93_RS36845	COG0515	serine threonine protein kinase
EPA93_RS36885	COG0515	serine threonine protein kinase
EPA93_RS36885	COG2815	serine threonine protein kinase
EPA93_RS36890	COG0484	heat shock protein binding
EPA93_RS36925	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EPA93_RS36930	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EPA93_RS36980	COG3548	integral membrane protein
EPA93_RS36985	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EPA93_RS36990	COG0477	Major facilitator Superfamily
EPA93_RS36995	COG2897	thiosulfate sulfurtransferase activity
EPA93_RS37015	COG4977	sequence-specific DNA binding
EPA93_RS37015	COG1917	Cupin 2, conserved barrel domain protein
EPA93_RS37020	COG2909	trisaccharide binding
EPA93_RS37045	COG3548	integral membrane protein
EPA93_RS37055	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EPA93_RS37070	COG1522	sequence-specific DNA binding
EPA93_RS37150	COG4948	Mandelate Racemase Muconate Lactonizing
EPA93_RS37160	COG2353	YceI-like domain
EPA93_RS37165	COG1228	amidohydrolase
EPA93_RS37185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EPA93_RS37205	COG2226	methyltransferase
EPA93_RS37225	COG3321	synthase
EPA93_RS37225	COG0604	alcohol dehydrogenase
EPA93_RS37225	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS37240	COG2045	Belongs to the ComB family
EPA93_RS37245	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EPA93_RS37250	COG0515	serine threonine protein kinase
EPA93_RS37250	COG2815	serine threonine protein kinase
EPA93_RS37255	COG0745	RESPONSE REGULATOR receiver
EPA93_RS37260	COG5002	protein histidine kinase activity
EPA93_RS37265	COG2202	Pas domain
EPA93_RS37265	COG2205	protein histidine kinase activity
EPA93_RS37280	COG1357	PFAM Pentapeptide repeats (8 copies)
EPA93_RS37280	COG0515	serine threonine protein kinase
EPA93_RS37285	COG1357	PFAM Pentapeptide repeats (8 copies)
EPA93_RS37285	COG0515	serine threonine protein kinase
EPA93_RS37290	COG1872	DUF167
EPA93_RS37305	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EPA93_RS37310	COG0484	heat shock protein binding
EPA93_RS37320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EPA93_RS37335	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
EPA93_RS37340	COG0459	protein refolding
EPA93_RS37345	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EPA93_RS37355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EPA93_RS37360	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EPA93_RS37360	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EPA93_RS37365	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EPA93_RS37375	COG2814	Major facilitator Superfamily
EPA93_RS37385	COG4636	protein conserved in cyanobacteria
EPA93_RS37390	COG0346	lactoylglutathione lyase activity
EPA93_RS37405	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EPA93_RS37410	COG0649	NAD binding
EPA93_RS37420	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EPA93_RS37425	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EPA93_RS37435	COG2815	serine threonine protein kinase
EPA93_RS37435	COG0515	serine threonine protein kinase
EPA93_RS37440	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EPA93_RS37450	COG0784	Response regulator, receiver
EPA93_RS37455	COG1381	Involved in DNA repair and RecF pathway recombination
EPA93_RS37480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS37490	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EPA93_RS37495	COG2264	protein methyltransferase activity
EPA93_RS37505	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EPA93_RS37505	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EPA93_RS37525	COG1595	DNA-templated transcription, initiation
EPA93_RS37540	COG0574	Belongs to the PEP-utilizing enzyme family
EPA93_RS37540	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EPA93_RS37545	COG1819	glycosyl
EPA93_RS37575	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EPA93_RS37580	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EPA93_RS37585	COG1515	deoxyribonuclease V activity
EPA93_RS37590	COG5002	protein histidine kinase activity
EPA93_RS37595	COG0745	RESPONSE REGULATOR receiver
EPA93_RS37600	COG0445	tRNA wobble uridine modification
EPA93_RS37620	COG1595	DNA-templated transcription, initiation
EPA93_RS37635	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EPA93_RS37650	COG2197	response regulator
EPA93_RS37675	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EPA93_RS37695	COG0463	Glycosyl transferase, family 2
EPA93_RS37700	COG0124	histidyl-tRNA synthetase
EPA93_RS37715	COG1316	TRANSCRIPTIONal
EPA93_RS37720	COG1496	oxidoreductase activity
EPA93_RS37725	COG0640	Transcriptional regulator
EPA93_RS37735	COG0346	lactoylglutathione lyase activity
EPA93_RS37745	COG2186	Transcriptional regulator
EPA93_RS37750	COG2223	nitrite transmembrane transporter activity
EPA93_RS37760	COG1733	regulation of RNA biosynthetic process
EPA93_RS37795	COG1175	transmembrane transport
EPA93_RS37800	COG0395	ABC-type sugar transport system, permease component
EPA93_RS37805	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS37810	COG1131	(ABC) transporter
EPA93_RS37845	COG1331	Highly conserved protein containing a thioredoxin domain
EPA93_RS37890	COG1305	Transglutaminase-like
EPA93_RS37910	COG1595	DNA-templated transcription, initiation
EPA93_RS37930	COG0395	ABC-type sugar transport system, permease component
EPA93_RS37935	COG1175	transmembrane transport
EPA93_RS37940	COG1653	transport
EPA93_RS37960	COG1191	sigma factor activity
EPA93_RS37965	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
EPA93_RS37970	COG1260	myo-inositol-1-phosphate synthase
EPA93_RS37980	COG0529	Catalyzes the synthesis of activated sulfate
EPA93_RS37980	COG2046	Belongs to the sulfate adenylyltransferase family
EPA93_RS37985	COG2046	Belongs to the sulfate adenylyltransferase family
EPA93_RS37995	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EPA93_RS38000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EPA93_RS38025	COG0542	response to heat
EPA93_RS38045	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EPA93_RS38050	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EPA93_RS38060	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EPA93_RS38065	COG2224	Isocitrate lyase
EPA93_RS38070	COG0653	protein targeting
EPA93_RS38085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EPA93_RS38095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EPA93_RS38105	COG1620	l-lactate permease
EPA93_RS38145	COG2815	serine threonine protein kinase
EPA93_RS38145	COG0515	serine threonine protein kinase
EPA93_RS38250	COG4948	Mandelate Racemase Muconate Lactonizing
EPA93_RS38270	COG0746	molybdenum cofactor guanylyltransferase activity
EPA93_RS38275	COG1304	FMN binding
EPA93_RS38285	COG0254	rRNA binding
EPA93_RS38290	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EPA93_RS38295	COG3872	metal-dependent enzyme
EPA93_RS38305	COG0561	phosphatase activity
EPA93_RS38320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EPA93_RS38335	COG1595	DNA-templated transcription, initiation
EPA93_RS38340	COG1609	Transcriptional regulator
EPA93_RS38350	COG0372	Belongs to the citrate synthase family
EPA93_RS38370	COG0076	glutamate decarboxylase activity
EPA93_RS38380	COG0719	Fe-S assembly protein
EPA93_RS38425	COG2205	protein histidine kinase activity
EPA93_RS38440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EPA93_RS38450	COG0454	-acetyltransferase
EPA93_RS38465	COG1846	Transcriptional regulator
EPA93_RS38470	COG1234	tRNA 3'-trailer cleavage
EPA93_RS38495	COG0667	Aldo Keto reductase
EPA93_RS38500	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EPA93_RS38505	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EPA93_RS38565	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EPA93_RS38570	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EPA93_RS38585	COG2814	Major facilitator Superfamily
EPA93_RS38595	COG0668	transmembrane transport
EPA93_RS38600	COG0671	phosphoesterase, PA-phosphatase related
EPA93_RS38605	COG1597	lipid kinase activity
EPA93_RS38610	COG2264	protein methyltransferase activity
EPA93_RS38620	COG1595	DNA-templated transcription, initiation
EPA93_RS38630	COG1215	transferase activity, transferring glycosyl groups
EPA93_RS38640	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EPA93_RS38645	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
EPA93_RS38650	COG0596	Alpha beta hydrolase
EPA93_RS38655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EPA93_RS38660	COG1584	GPR1 FUN34 yaaH family protein
EPA93_RS38665	COG1648	precorrin-2 dehydrogenase activity
EPA93_RS38665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EPA93_RS38670	COG1648	precorrin-2 dehydrogenase activity
EPA93_RS38670	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EPA93_RS38675	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EPA93_RS38695	COG1175	transmembrane transport
EPA93_RS38700	COG0395	ABC-type sugar transport system, permease component
EPA93_RS38705	COG1609	Transcriptional regulator
EPA93_RS38715	COG1609	Transcriptional regulator
EPA93_RS38720	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EPA93_RS38725	COG0488	(ABC) transporter
EPA93_RS38750	COG2226	methyltransferase
EPA93_RS38760	COG0189	ligase activity
EPA93_RS38765	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EPA93_RS38770	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EPA93_RS38775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EPA93_RS38780	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EPA93_RS38785	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EPA93_RS38790	COG0066	3-isopropylmalate dehydratase activity
EPA93_RS38795	COG0473	3-isopropylmalate dehydrogenase activity
EPA93_RS38810	COG0085	RNA polymerase activity
EPA93_RS38880	COG0477	Major facilitator Superfamily
EPA93_RS38920	COG2197	response regulator
EPA93_RS38935	COG1078	dGTPase activity
EPA93_RS38945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EPA93_RS38975	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EPA93_RS38990	COG2909	trisaccharide binding
EPA93_RS38995	COG2912	Transglutaminase-like superfamily
EPA93_RS39000	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EPA93_RS39005	COG2909	trisaccharide binding
EPA93_RS39010	COG1914	H( )-stimulated, divalent metal cation uptake system
EPA93_RS39040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EPA93_RS39055	COG2267	carboxylic ester hydrolase activity
EPA93_RS39065	COG0022	dehydrogenase e1 component
EPA93_RS39070	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EPA93_RS39075	COG3199	ATP-NAD kinase
EPA93_RS39085	COG0542	response to heat
EPA93_RS39090	COG0154	amidase activity
EPA93_RS39105	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EPA93_RS39130	COG1012	belongs to the aldehyde dehydrogenase family
EPA93_RS39150	COG0508	dehydrogenase complex catalyzes the overall conversion of
EPA93_RS39160	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EPA93_RS39165	COG2755	lipolytic protein G-D-S-L family
EPA93_RS39165	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EPA93_RS39170	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EPA93_RS39170	COG0519	Catalyzes the synthesis of GMP from XMP
EPA93_RS39175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS39180	COG0604	alcohol dehydrogenase
EPA93_RS39185	COG2226	methyltransferase
EPA93_RS39190	COG0515	serine threonine protein kinase
EPA93_RS39190	COG2815	serine threonine protein kinase
EPA93_RS39200	COG0318	PFAM AMP-dependent synthetase and ligase
EPA93_RS39225	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EPA93_RS39235	COG0442	prolyl-tRNA aminoacylation
EPA93_RS39240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPA93_RS39245	COG0442	prolyl-tRNA aminoacylation
EPA93_RS39250	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EPA93_RS39275	COG1172	Belongs to the binding-protein-dependent transport system permease family
EPA93_RS39295	COG1070	Carbohydrate kinase
EPA93_RS39300	COG1830	Aldolase
EPA93_RS39315	COG1732	Glycine betaine
EPA93_RS39320	COG1174	glycine betaine transport
EPA93_RS39340	COG2815	serine threonine protein kinase
EPA93_RS39340	COG0515	serine threonine protein kinase
EPA93_RS39355	COG1686	Belongs to the peptidase S11 family
EPA93_RS39360	COG4585	Histidine kinase
EPA93_RS39365	COG2197	response regulator
EPA93_RS39420	COG0410	ABC transporter
EPA93_RS39425	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EPA93_RS39430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EPA93_RS39445	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EPA93_RS39450	COG1012	belongs to the aldehyde dehydrogenase family
EPA93_RS39465	COG1131	(ABC) transporter
EPA93_RS39510	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EPA93_RS39515	COG0297	glycogen (starch) synthase activity
EPA93_RS39530	COG0489	protein tyrosine kinase activity
EPA93_RS39555	COG0438	transferase activity, transferring glycosyl groups
EPA93_RS39625	COG2301	Belongs to the HpcH HpaI aldolase family
EPA93_RS39635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPA93_RS39635	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPA93_RS39640	COG1131	(ABC) transporter
EPA93_RS39660	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EPA93_RS39665	COG5002	protein histidine kinase activity
EPA93_RS39685	COG1716	ATPase activity
EPA93_RS39705	COG1176	ABC-type spermidine putrescine transport system, permease component I
EPA93_RS39715	COG3842	ATPase activity
EPA93_RS39720	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EPA93_RS39730	COG0515	serine threonine protein kinase
EPA93_RS39730	COG2815	serine threonine protein kinase
EPA93_RS39735	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EPA93_RS39750	COG0515	serine threonine protein kinase
EPA93_RS39750	COG2815	serine threonine protein kinase
EPA93_RS39765	COG2205	protein histidine kinase activity
EPA93_RS39790	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EPA93_RS39790	COG2080	2 iron, 2 sulfur cluster binding
EPA93_RS39800	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EPA93_RS39830	COG1175	transmembrane transport
EPA93_RS39835	COG3833	ABC-type maltose transport systems, permease component
EPA93_RS39850	COG1012	belongs to the aldehyde dehydrogenase family
EPA93_RS39860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EPA93_RS39865	COG0765	amino acid transport
EPA93_RS39870	COG0765	amino acid transport
EPA93_RS39875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPA93_RS39885	COG2267	carboxylic ester hydrolase activity
EPA93_RS39895	COG2815	serine threonine protein kinase
EPA93_RS39895	COG0515	serine threonine protein kinase
EPA93_RS39900	COG0583	DNA-binding transcription factor activity
EPA93_RS39950	COG0714	Associated with various cellular activities
EPA93_RS39965	COG1131	(ABC) transporter
EPA93_RS39975	COG1063	alcohol dehydrogenase
EPA93_RS39980	COG2271	Major facilitator Superfamily
EPA93_RS39995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EPA93_RS40000	COG1012	belongs to the aldehyde dehydrogenase family
EPA93_RS40005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EPA93_RS40010	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EPA93_RS40015	COG1122	ATPase activity
EPA93_RS40020	COG1122	ATPase activity
EPA93_RS40030	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EPA93_RS40035	COG2204	response regulator
EPA93_RS40045	COG2268	Band 7 protein
EPA93_RS40070	COG0215	cysteine-tRNA ligase activity
EPA93_RS40075	COG1410	methionine synthase
EPA93_RS40075	COG0646	methionine synthase
EPA93_RS40090	COG2319	Wd-40 repeat
EPA93_RS40090	COG5635	Nacht domain
EPA93_RS40110	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EPA93_RS40115	COG0667	Aldo Keto reductase
EPA93_RS40120	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EPA93_RS40145	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EPA93_RS40150	COG0668	transmembrane transport
EPA93_RS40155	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EPA93_RS40160	COG0424	maF-like protein
EPA93_RS40165	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EPA93_RS40195	COG1233	COG1233 Phytoene dehydrogenase and related
EPA93_RS40200	COG0497	DNA recombination
EPA93_RS40210	COG0617	tRNA 3'-terminal CCA addition
EPA93_RS40230	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EPA93_RS40235	COG0022	dehydrogenase e1 component
EPA93_RS40240	COG0508	dehydrogenase complex catalyzes the overall conversion of
EPA93_RS40245	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EPA93_RS40255	COG0745	RESPONSE REGULATOR receiver
EPA93_RS40260	COG0515	serine threonine protein kinase
EPA93_RS40260	COG2815	serine threonine protein kinase
EPA93_RS40315	COG1566	PFAM secretion protein HlyD family protein
EPA93_RS40320	COG0577	efflux transmembrane transporter activity
EPA93_RS40320	COG1136	(ABC) transporter
EPA93_RS40325	COG0577	efflux transmembrane transporter activity
EPA93_RS40325	COG1136	(ABC) transporter
EPA93_RS40330	COG0577	efflux transmembrane transporter activity
EPA93_RS40330	COG1136	(ABC) transporter
EPA93_RS40335	COG0577	efflux transmembrane transporter activity
EPA93_RS40335	COG1136	(ABC) transporter
EPA93_RS40360	COG0745	RESPONSE REGULATOR receiver
EPA93_RS40385	COG2815	serine threonine protein kinase
EPA93_RS40385	COG0515	serine threonine protein kinase
EPA93_RS40405	COG2815	serine threonine protein kinase
EPA93_RS40405	COG0515	serine threonine protein kinase
EPA93_RS40430	COG0670	Belongs to the BI1 family
EPA93_RS40435	COG3118	belongs to the thioredoxin family
EPA93_RS40440	COG2188	Transcriptional regulator
EPA93_RS40475	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EPA93_RS40480	COG0784	Response regulator, receiver
EPA93_RS40480	COG2205	protein histidine kinase activity
EPA93_RS40485	COG2205	protein histidine kinase activity
EPA93_RS40485	COG4999	Histidine kinase
EPA93_RS40485	COG3437	response regulator, receiver
EPA93_RS40485	COG3850	Histidine kinase
EPA93_RS40505	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EPA93_RS40520	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EPA93_RS40525	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EPA93_RS40530	COG1960	acyl-CoA dehydrogenase activity
EPA93_RS40550	COG1598	PFAM Uncharacterised protein family UPF0150
EPA93_RS40560	COG0470	DNA polymerase III
EPA93_RS40565	COG1024	Enoyl-CoA hydratase
EPA93_RS40580	COG0789	Transcriptional regulator
EPA93_RS40580	COG4978	Transcriptional regulator
EPA93_RS40585	COG4555	ABC transporter
EPA93_RS40610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EPA93_RS40615	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EPA93_RS40620	COG1040	competence protein
EPA93_RS40625	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EPA93_RS40630	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EPA93_RS40645	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EPA93_RS40670	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EPA93_RS40670	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EPA93_RS40675	COG0436	Aminotransferase
EPA93_RS40685	COG0745	RESPONSE REGULATOR receiver
EPA93_RS40690	COG5002	protein histidine kinase activity
EPA93_RS40705	COG0318	PFAM AMP-dependent synthetase and ligase
EPA93_RS40720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EPA93_RS40725	COG1132	(ABC) transporter
EPA93_RS40740	COG2226	methyltransferase
EPA93_RS40745	COG0456	acetyltransferase
EPA93_RS40765	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EPA93_RS40770	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EPA93_RS40775	COG4956	integral membrane protein (PIN domain superfamily)
EPA93_RS40780	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EPA93_RS40790	COG0539	negative regulation of cytoplasmic translation
EPA93_RS40795	COG0494	nUDIX hydrolase
EPA93_RS40805	COG3191	aminopeptidase activity
EPA93_RS40810	COG0456	acetyltransferase
EPA93_RS40815	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EPA93_RS40820	COG0363	glucosamine-6-phosphate deaminase activity
EPA93_RS40830	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EPA93_RS40835	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EPA93_RS40840	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EPA93_RS40845	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EPA93_RS40865	COG0772	Belongs to the SEDS family
EPA93_RS40880	COG0196	riboflavin kinase activity
EPA93_RS40885	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EPA93_RS40890	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EPA93_RS40895	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EPA93_RS40900	COG3064	Membrane
EPA93_RS40900	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EPA93_RS40905	COG2740	Nucleic-acid-binding protein implicated in transcription termination
EPA93_RS40910	COG0195	Participates in both transcription termination and antitermination
EPA93_RS40920	COG0719	Fe-S assembly protein
EPA93_RS40955	COG0724	RNA recognition motif
EPA93_RS40960	COG1960	acyl-CoA dehydrogenase activity
EPA93_RS40975	COG1253	flavin adenine dinucleotide binding
EPA93_RS40980	COG0247	lactate metabolic process
EPA93_RS40980	COG2181	nitrate reductase activity
EPA93_RS40990	COG2086	electron transfer activity
EPA93_RS41025	COG0438	transferase activity, transferring glycosyl groups
EPA93_RS41035	COG0859	PFAM glycosyl transferase family 9
EPA93_RS41080	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EPA93_RS41100	COG0859	PFAM glycosyl transferase family 9
EPA93_RS41110	COG0859	PFAM glycosyl transferase family 9
EPA93_RS41125	COG4166	transmembrane transport
EPA93_RS41130	COG0859	PFAM glycosyl transferase family 9
EPA93_RS41140	COG0859	PFAM glycosyl transferase family 9
EPA93_RS41165	COG4974	Belongs to the 'phage' integrase family
EPA93_RS41170	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
EPA93_RS41190	COG2154	pterin-4-alpha-carbinolamine dehydratase
EPA93_RS41200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPA93_RS41215	COG1940	carbohydrate kinase activity
EPA93_RS41225	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPA93_RS41240	COG0789	Transcriptional regulator
EPA93_RS41240	COG4978	Transcriptional regulator
EPA93_RS41250	COG1960	acyl-CoA dehydrogenase activity
EPA93_RS41265	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EPA93_RS41270	COG2045	Belongs to the ComB family
EPA93_RS41295	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EPA93_RS41305	COG5002	protein histidine kinase activity
EPA93_RS41325	COG0437	4 iron, 4 sulfur cluster binding
EPA93_RS41330	COG3383	formate dehydrogenase (NAD+) activity
EPA93_RS41330	COG0243	molybdopterin cofactor binding
EPA93_RS41340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS41345	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EPA93_RS41350	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EPA93_RS41355	COG0395	ABC-type sugar transport system, permease component
EPA93_RS41360	COG1175	transmembrane transport
EPA93_RS41365	COG2182	Extracellular solute-binding protein
EPA93_RS41370	COG1846	Transcriptional regulator
EPA93_RS41395	COG0440	acetolactate synthase activity
EPA93_RS41410	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EPA93_RS41435	COG2205	protein histidine kinase activity
EPA93_RS41450	COG1482	cell wall glycoprotein biosynthetic process
EPA93_RS41455	COG3118	belongs to the thioredoxin family
EPA93_RS41470	COG0745	RESPONSE REGULATOR receiver
EPA93_RS41495	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EPA93_RS41500	COG0632	four-way junction helicase activity
EPA93_RS41505	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EPA93_RS41510	COG0217	transcriptional regulatory protein
EPA93_RS41515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EPA93_RS41520	COG0792	nuclease activity
EPA93_RS41530	COG0802	atpase or kinase
EPA93_RS41535	COG1214	PFAM Peptidase M22, glycoprotease
EPA93_RS41540	COG0456	acetyltransferase
EPA93_RS41545	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EPA93_RS41550	COG1940	carbohydrate kinase activity
EPA93_RS41560	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPA93_RS41565	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EPA93_RS41575	COG0745	RESPONSE REGULATOR receiver
EPA93_RS41580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPA93_RS41585	COG0601	transmembrane transport
EPA93_RS41590	COG4166	transmembrane transport
EPA93_RS41595	COG4166	transmembrane transport
EPA93_RS41600	COG4608	Belongs to the ABC transporter superfamily
EPA93_RS41605	COG0444	Belongs to the ABC transporter superfamily
EPA93_RS41610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPA93_RS41615	COG0601	transmembrane transport
EPA93_RS41620	COG0747	negative chemotaxis
EPA93_RS41665	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EPA93_RS41670	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EPA93_RS41680	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EPA93_RS41685	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EPA93_RS41690	COG0473	3-isopropylmalate dehydrogenase activity
EPA93_RS41710	COG1293	RNA-binding protein homologous to eukaryotic snRNP
EPA93_RS41720	COG0571	ribonuclease III activity
EPA93_RS41730	COG0646	methionine synthase
EPA93_RS41730	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EPA93_RS41740	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EPA93_RS41745	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
EPA93_RS41755	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EPA93_RS41760	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EPA93_RS41765	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EPA93_RS41780	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS41790	COG2204	response regulator
EPA93_RS41810	COG0515	serine threonine protein kinase
EPA93_RS41810	COG2815	serine threonine protein kinase
EPA93_RS41815	COG5002	protein histidine kinase activity
EPA93_RS41815	COG3850	Histidine kinase
EPA93_RS41820	COG0745	RESPONSE REGULATOR receiver
EPA93_RS41825	COG1132	(ABC) transporter
EPA93_RS41830	COG0189	ligase activity
EPA93_RS41835	COG1063	alcohol dehydrogenase
EPA93_RS41855	COG1013	pyruvate-flavodoxin oxidoreductase activity
EPA93_RS41860	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EPA93_RS41860	COG0674	pyruvate-flavodoxin oxidoreductase activity
EPA93_RS41870	COG0326	Molecular chaperone. Has ATPase activity
EPA93_RS41875	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EPA93_RS41885	COG0515	serine threonine protein kinase
EPA93_RS41890	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EPA93_RS41905	COG1132	(ABC) transporter
EPA93_RS41915	COG0189	ligase activity
EPA93_RS41925	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EPA93_RS41930	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EPA93_RS41960	COG5002	protein histidine kinase activity
EPA93_RS41965	COG1595	DNA-templated transcription, initiation
EPA93_RS41980	COG0785	Cytochrome C biogenesis protein
EPA93_RS41990	COG0515	serine threonine protein kinase
EPA93_RS41990	COG2815	serine threonine protein kinase
EPA93_RS41995	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EPA93_RS42000	COG0515	serine threonine protein kinase
EPA93_RS42000	COG2815	serine threonine protein kinase
EPA93_RS42020	COG2183	response to ionizing radiation
EPA93_RS42045	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EPA93_RS42050	COG0517	IMP dehydrogenase activity
EPA93_RS42050	COG1994	Peptidase M50
EPA93_RS42065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EPA93_RS42070	COG2124	cytochrome p450
EPA93_RS42085	COG4585	Histidine kinase
EPA93_RS42100	COG3511	phospholipase C
EPA93_RS42115	COG0631	protein serine/threonine phosphatase activity
EPA93_RS42125	COG1449	Belongs to the glycosyl hydrolase 57 family
EPA93_RS42130	COG2814	Major facilitator Superfamily
EPA93_RS42135	COG0750	zinc metalloprotease
EPA93_RS42150	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EPA93_RS42185	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EPA93_RS42190	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EPA93_RS42195	COG2814	Major facilitator Superfamily
EPA93_RS42250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EPA93_RS42260	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EPA93_RS42265	COG0205	6-phosphofructokinase activity
EPA93_RS42285	COG1045	serine acetyltransferase
EPA93_RS42300	COG0515	serine threonine protein kinase
EPA93_RS42300	COG2815	serine threonine protein kinase
EPA93_RS42305	COG0583	DNA-binding transcription factor activity
EPA93_RS42315	COG0745	RESPONSE REGULATOR receiver
EPA93_RS42320	COG0784	Response regulator, receiver
EPA93_RS42320	COG5002	protein histidine kinase activity
EPA93_RS42320	COG2205	protein histidine kinase activity
EPA93_RS42335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS42350	COG1832	CoA-binding protein
EPA93_RS42355	COG1070	Carbohydrate kinase
EPA93_RS42375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EPA93_RS42435	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EPA93_RS42460	COG1321	iron dependent repressor
EPA93_RS42465	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EPA93_RS42480	COG2197	response regulator
EPA93_RS42490	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EPA93_RS42515	COG0297	glycogen (starch) synthase activity
EPA93_RS42530	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
EPA93_RS42545	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EPA93_RS42555	COG0243	molybdopterin cofactor binding
EPA93_RS42560	COG2205	protein histidine kinase activity
EPA93_RS42560	COG2202	Pas domain
EPA93_RS42580	COG2271	Major facilitator Superfamily
EPA93_RS42590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EPA93_RS42600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPA93_RS42605	COG0765	amino acid transport
EPA93_RS42615	COG0469	pyruvate kinase activity
EPA93_RS42620	COG0228	four-way junction DNA binding
EPA93_RS42625	COG1837	Belongs to the UPF0109 family
EPA93_RS42630	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EPA93_RS42640	COG0328	RNA-DNA hybrid ribonuclease activity
EPA93_RS42650	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EPA93_RS42655	COG1012	belongs to the aldehyde dehydrogenase family
EPA93_RS42695	COG0793	Belongs to the peptidase S41A family
EPA93_RS42695	COG4946	Tricorn protease homolog
EPA93_RS42700	COG0544	peptidyl-prolyl cis-trans isomerase activity
EPA93_RS42705	COG0540	Belongs to the ATCase OTCase family
EPA93_RS42710	COG0505	Belongs to the CarA family
EPA93_RS42715	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EPA93_RS42720	COG1053	succinate dehydrogenase
EPA93_RS42725	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EPA93_RS42730	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EPA93_RS42740	COG0284	orotidine-5'-phosphate decarboxylase activity
EPA93_RS42750	COG0018	arginyl-trna synthetase
EPA93_RS42765	COG1176	ABC-type spermidine putrescine transport system, permease component I
EPA93_RS42775	COG3842	ATPase activity
EPA93_RS42810	COG0584	glycerophosphoryl diester phosphodiesterase
EPA93_RS42815	COG0463	Glycosyl transferase, family 2
EPA93_RS42840	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EPA93_RS42860	COG0640	Transcriptional regulator
EPA93_RS42870	COG0193	aminoacyl-tRNA hydrolase activity
EPA93_RS42885	COG0154	amidase activity
EPA93_RS42890	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EPA93_RS42895	COG1254	Belongs to the acylphosphatase family
EPA93_RS42900	COG0714	Associated with various cellular activities
EPA93_RS42905	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
EPA93_RS42925	COG4555	ABC transporter
EPA93_RS42965	COG1959	2 iron, 2 sulfur cluster binding
EPA93_RS42970	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EPA93_RS42975	COG2409	Drug exporters of the RND superfamily
EPA93_RS42990	COG2205	protein histidine kinase activity
EPA93_RS43015	COG0745	RESPONSE REGULATOR receiver
EPA93_RS43020	COG0835	chemotaxis
EPA93_RS43025	COG0840	transmembrane signaling receptor activity
EPA93_RS43030	COG0784	Response regulator, receiver
EPA93_RS43030	COG2198	Histidine kinase
EPA93_RS43030	COG0643	Histidine kinase
EPA93_RS43040	COG0473	3-isopropylmalate dehydrogenase activity
EPA93_RS43045	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EPA93_RS43065	COG2723	6-phospho-beta-galactosidase activity
EPA93_RS43080	COG0626	cystathionine gamma-synthase activity
EPA93_RS43090	COG0561	phosphatase activity
EPA93_RS43095	COG0489	protein tyrosine kinase activity
EPA93_RS43100	COG2816	NAD+ diphosphatase activity
EPA93_RS43120	COG2226	methyltransferase
EPA93_RS43125	COG0142	geranyltranstransferase activity
EPA93_RS43145	COG0010	Belongs to the arginase family
EPA93_RS43150	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EPA93_RS43155	COG1899	peptidyl-lysine modification to peptidyl-hypusine
EPA93_RS43160	COG0556	nucleotide-excision repair
EPA93_RS43185	COG2190	(PTS) system
EPA93_RS43185	COG2211	Major facilitator Superfamily
EPA93_RS43190	COG0492	ferredoxin-NADP+ reductase activity
EPA93_RS43195	COG2197	response regulator
EPA93_RS43200	COG4585	Histidine kinase
EPA93_RS43215	COG1051	belongs to the nudix hydrolase family
EPA93_RS43220	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EPA93_RS43260	COG2003	Belongs to the UPF0758 family
EPA93_RS43300	COG2815	serine threonine protein kinase
EPA93_RS43300	COG0515	serine threonine protein kinase
EPA93_RS43360	COG3311	Transcriptional regulator
EPA93_RS43385	COG2195	Cleaves the N-terminal amino acid of tripeptides
EPA93_RS43390	COG1011	Hydrolase
EPA93_RS43400	COG0316	Belongs to the HesB IscA family
EPA93_RS43435	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EPA93_RS43440	COG0546	phosphoglycolate phosphatase activity
EPA93_RS43445	COG0322	excinuclease ABC activity
EPA93_RS43450	COG3842	ATPase activity
EPA93_RS43490	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EPA93_RS43495	COG1606	tRNA processing
EPA93_RS43505	COG0436	Aminotransferase
EPA93_RS43510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EPA93_RS43525	COG2207	Transcriptional regulator
EPA93_RS43525	COG1917	Cupin 2, conserved barrel domain protein
EPA93_RS43545	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EPA93_RS43545	COG1372	Participates in initiation and elongation during chromosome replication
EPA93_RS43560	COG1058	Belongs to the CinA family
EPA93_RS43560	COG1546	Belongs to the CinA family
EPA93_RS43565	COG1914	H( )-stimulated, divalent metal cation uptake system
EPA93_RS43580	COG4770	biotin carboxylase activity
EPA93_RS43585	COG1024	Enoyl-CoA hydratase
EPA93_RS43590	COG0598	Magnesium transport protein CorA
EPA93_RS43595	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EPA93_RS43605	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EPA93_RS43630	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EPA93_RS43645	COG1285	pathogenesis
EPA93_RS43660	COG1929	Belongs to the glycerate kinase type-1 family
EPA93_RS43670	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EPA93_RS43685	COG1472	Belongs to the glycosyl hydrolase 3 family
EPA93_RS43700	COG0673	inositol 2-dehydrogenase activity
EPA93_RS43710	COG0395	ABC-type sugar transport system, permease component
EPA93_RS43715	COG1175	transmembrane transport
EPA93_RS43745	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
EPA93_RS43765	COG1802	Transcriptional regulator
EPA93_RS43770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EPA93_RS43775	COG3938	Belongs to the proline racemase family
EPA93_RS43780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EPA93_RS43810	COG4585	Histidine kinase
EPA93_RS43815	COG2197	response regulator
EPA93_RS43850	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EPA93_RS43855	COG0298	carbon dioxide binding
EPA93_RS43860	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
EPA93_RS43865	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
EPA93_RS43870	COG0375	protein maturation
EPA93_RS43905	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
EPA93_RS43930	COG1609	Transcriptional regulator
EPA93_RS43940	COG1587	Uroporphyrinogen-III synthase
EPA93_RS43950	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EPA93_RS43955	COG2815	serine threonine protein kinase
EPA93_RS43955	COG0515	serine threonine protein kinase
EPA93_RS43970	COG0515	serine threonine protein kinase
EPA93_RS43970	COG2815	serine threonine protein kinase
EPA93_RS43990	COG0477	Major facilitator Superfamily
EPA93_RS44025	COG0076	glutamate decarboxylase activity
EPA93_RS44045	COG0825	malonyl-CoA metabolic process
EPA93_RS44050	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EPA93_RS44055	COG0552	protein localization to endoplasmic reticulum
EPA93_RS44065	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EPA93_RS44085	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EPA93_RS44095	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS44100	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EPA93_RS44125	COG3457	Alanine racemase
EPA93_RS44130	COG0626	cystathionine gamma-synthase activity
EPA93_RS44135	COG1735	metal-dependent hydrolase with the TIM-barrel fold
EPA93_RS44185	COG1653	transport
EPA93_RS44220	COG0604	alcohol dehydrogenase
EPA93_RS44235	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EPA93_RS44260	COG0477	Major facilitator Superfamily
EPA93_RS44285	COG1132	(ABC) transporter
EPA93_RS44290	COG1132	(ABC) transporter
EPA93_RS44295	COG2226	methyltransferase
EPA93_RS44320	COG2267	carboxylic ester hydrolase activity
EPA93_RS44340	COG1309	transcriptional regulator
EPA93_RS44370	COG2197	response regulator
EPA93_RS44385	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EPA93_RS44390	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
EPA93_RS44395	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EPA93_RS44405	COG2508	Transcriptional regulator
EPA93_RS44410	COG0009	L-threonylcarbamoyladenylate synthase
EPA93_RS44425	COG4214	carbohydrate transport
EPA93_RS44435	COG4213	ABC transporter substrate-binding protein
EPA93_RS44440	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EPA93_RS44445	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EPA93_RS44450	COG3933	PFAM sigma-54 factor interaction domain-containing protein
EPA93_RS44450	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EPA93_RS44455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS44485	COG2204	response regulator
EPA93_RS44500	COG1993	acr, cog1993
EPA93_RS44505	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EPA93_RS44510	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EPA93_RS44525	COG1940	carbohydrate kinase activity
EPA93_RS44535	COG1175	transmembrane transport
EPA93_RS44540	COG0395	ABC-type sugar transport system, permease component
EPA93_RS44550	COG1063	alcohol dehydrogenase
EPA93_RS44555	COG0583	DNA-binding transcription factor activity
EPA93_RS44570	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EPA93_RS44580	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EPA93_RS44590	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EPA93_RS44640	COG1607	acyl-coa hydrolase
EPA93_RS44660	COG3546	catalase activity
EPA93_RS44670	COG4894	glucomannan catabolic process
EPA93_RS44680	COG5002	protein histidine kinase activity
EPA93_RS44715	COG2084	Dehydrogenase
EPA93_RS44725	COG0330	HflC and HflK could
EPA93_RS44730	COG0673	inositol 2-dehydrogenase activity
EPA93_RS44740	COG0673	inositol 2-dehydrogenase activity
EPA93_RS44760	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
EPA93_RS44765	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EPA93_RS44800	COG2226	methyltransferase
EPA93_RS44830	COG1131	(ABC) transporter
EPA93_RS44855	COG1418	mRNA catabolic process
EPA93_RS44860	COG5002	protein histidine kinase activity
EPA93_RS44885	COG0484	heat shock protein binding
EPA93_RS44900	COG0187	DNA topoisomerase II activity
EPA93_RS44905	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EPA93_RS44910	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EPA93_RS44925	COG1230	cation diffusion facilitator family transporter
EPA93_RS44935	COG3665	Urea carboxylase-associated protein
EPA93_RS44940	COG2508	Transcriptional regulator
EPA93_RS44955	COG0393	Putative heavy-metal-binding
EPA93_RS44965	COG0402	S-adenosylhomocysteine deaminase activity
EPA93_RS44970	COG3852	Histidine kinase
EPA93_RS44975	COG2204	response regulator
EPA93_RS45005	COG0477	Major facilitator Superfamily
EPA93_RS45015	COG2124	cytochrome p450
EPA93_RS45025	COG2233	PERMEase
EPA93_RS45030	COG0549	Belongs to the carbamate kinase family
EPA93_RS45060	COG3835	regulator
EPA93_RS45065	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EPA93_RS45070	COG1304	FMN binding
EPA93_RS45095	COG2801	Transposase and inactivated derivatives
EPA93_RS45105	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EPA93_RS45110	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EPA93_RS45115	COG0446	pyridine nucleotide-disulphide oxidoreductase
EPA93_RS45130	COG0640	Transcriptional regulator
EPA93_RS45135	COG2072	flavoprotein involved in K transport
EPA93_RS45160	COG1595	DNA-templated transcription, initiation
EPA93_RS45165	COG2226	methyltransferase
EPA93_RS45260	COG2124	cytochrome p450
EPA93_RS45265	COG2226	methyltransferase
EPA93_RS45305	COG2814	Major facilitator Superfamily
EPA93_RS45360	COG0784	Response regulator, receiver
EPA93_RS45380	COG0515	serine threonine protein kinase
EPA93_RS45380	COG2815	serine threonine protein kinase
EPA93_RS45420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EPA93_RS45495	COG1131	(ABC) transporter
EPA93_RS45505	COG0367	asparagine synthase
EPA93_RS45555	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EPA93_RS45565	COG0395	ABC-type sugar transport system, permease component
EPA93_RS45570	COG1175	transmembrane transport
EPA93_RS45585	COG1609	Transcriptional regulator
EPA93_RS45635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPA93_RS45650	COG2814	Major facilitator Superfamily
EPA93_RS45655	COG0583	DNA-binding transcription factor activity
EPA93_RS45680	COG2124	cytochrome p450
EPA93_RS45685	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EPA93_RS45710	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EPA93_RS45725	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS45735	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EPA93_RS45745	COG3848	Pyruvate phosphate dikinase
EPA93_RS45745	COG0574	Belongs to the PEP-utilizing enzyme family
EPA93_RS45770	COG2909	trisaccharide binding
EPA93_RS45815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPA93_RS45820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EPA93_RS45845	COG0076	glutamate decarboxylase activity
EPA93_RS45850	COG2329	Antibiotic biosynthesis monooxygenase
EPA93_RS45865	COG1280	lysine exporter protein (LysE YggA)
EPA93_RS45885	COG0318	PFAM AMP-dependent synthetase and ligase
EPA93_RS45935	COG0515	serine threonine protein kinase
EPA93_RS45935	COG2815	serine threonine protein kinase
EPA93_RS45945	COG2814	Major facilitator Superfamily
EPA93_RS45995	COG2814	Major facilitator Superfamily
EPA93_RS46075	COG1175	transmembrane transport
EPA93_RS46080	COG0395	ABC-type sugar transport system, permease component
EPA93_RS46105	COG1063	alcohol dehydrogenase
EPA93_RS46125	COG5433	transposase activity
EPA93_RS46130	COG1609	Transcriptional regulator
EPA93_RS46140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EPA93_RS46180	COG0395	ABC-type sugar transport system, permease component
EPA93_RS46185	COG1175	transmembrane transport
EPA93_RS46195	COG2188	Transcriptional regulator
EPA93_RS46205	COG1940	carbohydrate kinase activity
EPA93_RS46235	COG4585	Histidine kinase
EPA93_RS46240	COG2197	response regulator
EPA93_RS46290	COG1960	acyl-CoA dehydrogenase activity
EPA93_RS46405	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EPA93_RS46405	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EPA93_RS46420	COG0596	Alpha beta hydrolase
EPA93_RS46425	COG1252	NADH dehydrogenase
EPA93_RS46430	COG2197	response regulator
EPA93_RS46440	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EPA93_RS46445	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EPA93_RS46455	COG1309	transcriptional regulator
EPA93_RS46475	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS46505	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS46520	COG4187	Peptidase family M20/M25/M40
EPA93_RS46530	COG5002	protein histidine kinase activity
EPA93_RS46535	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EPA93_RS46545	COG1175	transmembrane transport
EPA93_RS46550	COG0395	ABC-type sugar transport system, permease component
EPA93_RS46560	COG1132	(ABC) transporter
EPA93_RS46565	COG1132	(ABC) transporter
EPA93_RS46570	COG2378	regulation of single-species biofilm formation
EPA93_RS46580	COG1595	DNA-templated transcription, initiation
EPA93_RS46610	COG3848	Pyruvate phosphate dikinase
EPA93_RS46610	COG0574	Belongs to the PEP-utilizing enzyme family
EPA93_RS46635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPA93_RS46650	COG0788	formyltetrahydrofolate deformylase activity
EPA93_RS46665	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EPA93_RS46675	COG0531	amino acid
EPA93_RS46690	COG0612	Peptidase, M16
EPA93_RS46705	COG0105	UTP biosynthetic process
EPA93_RS46720	COG0515	serine threonine protein kinase
EPA93_RS46735	COG3848	Pyruvate phosphate dikinase
EPA93_RS46735	COG0574	Belongs to the PEP-utilizing enzyme family
EPA93_RS46755	COG0346	lactoylglutathione lyase activity
EPA93_RS46760	COG0400	carboxylic ester hydrolase activity
EPA93_RS46770	COG0530	calcium, potassium:sodium antiporter activity
EPA93_RS46780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EPA93_RS46785	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EPA93_RS46825	COG0477	Major facilitator Superfamily
EPA93_RS46835	COG2186	Transcriptional regulator
EPA93_RS46860	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EPA93_RS46870	COG1012	belongs to the aldehyde dehydrogenase family
EPA93_RS46875	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EPA93_RS46880	COG0789	Transcriptional regulator
EPA93_RS46885	COG2267	carboxylic ester hydrolase activity
EPA93_RS46910	COG0066	3-isopropylmalate dehydratase activity
EPA93_RS46915	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EPA93_RS46960	COG1139	Iron-sulfur cluster binding protein
EPA93_RS46970	COG3347	Dehydrogenase
EPA93_RS46970	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS46975	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS46985	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS46990	COG4166	transmembrane transport
EPA93_RS47010	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EPA93_RS47015	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EPA93_RS47015	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EPA93_RS47035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EPA93_RS47045	COG2309	aminopeptidase activity
EPA93_RS47055	COG0631	protein serine/threonine phosphatase activity
EPA93_RS47060	COG3850	Histidine kinase
EPA93_RS47060	COG5002	protein histidine kinase activity
EPA93_RS47065	COG0745	RESPONSE REGULATOR receiver
EPA93_RS47070	COG0745	RESPONSE REGULATOR receiver
EPA93_RS47085	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EPA93_RS47110	COG2226	methyltransferase
EPA93_RS47115	COG2226	methyltransferase
EPA93_RS47125	COG0542	response to heat
EPA93_RS47175	COG2226	methyltransferase
EPA93_RS47185	COG2814	Major facilitator Superfamily
EPA93_RS47195	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPA93_RS47215	COG0393	Putative heavy-metal-binding
EPA93_RS47220	COG0346	lactoylglutathione lyase activity
EPA93_RS47260	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EPA93_RS47265	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EPA93_RS47275	COG0602	queuosine metabolic process
EPA93_RS47285	COG0302	gtp cyclohydrolase
EPA93_RS47295	COG1122	ATPase activity
EPA93_RS47310	COG0402	S-adenosylhomocysteine deaminase activity
EPA93_RS47315	COG0515	serine threonine protein kinase
EPA93_RS47325	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
EPA93_RS47325	COG2508	Transcriptional regulator
EPA93_RS47350	COG3250	beta-galactosidase activity
EPA93_RS47355	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EPA93_RS47365	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EPA93_RS47375	COG0567	Dehydrogenase, E1 component
EPA93_RS47380	COG0508	dehydrogenase complex catalyzes the overall conversion of
EPA93_RS47385	COG2815	serine threonine protein kinase
EPA93_RS47385	COG0515	serine threonine protein kinase
EPA93_RS47395	COG2897	thiosulfate sulfurtransferase activity
EPA93_RS47460	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EPA93_RS47465	COG3959	Transketolase, thiamine diphosphate binding domain
EPA93_RS47490	COG1414	Transcriptional regulator
EPA93_RS47500	COG0515	serine threonine protein kinase
EPA93_RS47510	COG0515	serine threonine protein kinase
EPA93_RS47510	COG2815	serine threonine protein kinase
EPA93_RS47515	COG1309	transcriptional regulator
EPA93_RS47520	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EPA93_RS47540	COG0564	pseudouridine synthase activity
EPA93_RS47565	COG1063	alcohol dehydrogenase
EPA93_RS47575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EPA93_RS47575	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPA93_RS47575	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
EPA93_RS47590	COG0726	polysaccharide deacetylase
EPA93_RS47595	COG1472	Belongs to the glycosyl hydrolase 3 family
EPA93_RS47620	COG2151	metal-sulfur cluster biosynthetic enzyme
EPA93_RS47645	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EPA93_RS47655	COG1250	3-hydroxyacyl-CoA dehydrogenase
EPA93_RS47675	COG2957	Belongs to the agmatine deiminase family
EPA93_RS47680	COG2267	carboxylic ester hydrolase activity
EPA93_RS47695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPA93_RS47720	COG0489	protein tyrosine kinase activity
EPA93_RS47770	COG0492	ferredoxin-NADP+ reductase activity
EPA93_RS47775	COG0745	RESPONSE REGULATOR receiver
EPA93_RS47785	COG2197	response regulator
EPA93_RS47840	COG2223	nitrite transmembrane transporter activity
EPA93_RS47845	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EPA93_RS47850	COG1309	transcriptional regulator
EPA93_RS47875	COG2186	Transcriptional regulator
EPA93_RS47880	COG0179	Fumarylacetoacetate (FAA) hydrolase
EPA93_RS47890	COG4948	Mandelate Racemase Muconate Lactonizing
EPA93_RS47895	COG0738	Major facilitator superfamily
EPA93_RS47910	COG2814	Major facilitator Superfamily
EPA93_RS47930	COG3962	Belongs to the TPP enzyme family
EPA93_RS47945	COG1309	transcriptional regulator
EPA93_RS47960	COG1733	regulation of RNA biosynthetic process
EPA93_RS47970	COG1028	Short-chain dehydrogenase reductase Sdr
EPA93_RS47985	COG2814	Major facilitator Superfamily
EPA93_RS48010	COG0477	Major facilitator Superfamily
EPA93_RS48020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPA93_RS48085	COG2267	carboxylic ester hydrolase activity
EPA93_RS48090	COG1309	transcriptional regulator
EPA93_RS48115	COG2226	methyltransferase