locus-tag	class	description
B9G99_RS00015	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B9G99_RS00040	COG0395	ABC-type sugar transport system, permease component
B9G99_RS00045	COG3842	ATPase activity
B9G99_RS00055	COG0134	indole-3-glycerol-phosphate synthase activity
B9G99_RS00060	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B9G99_RS00065	COG0512	Glutamine amidotransferase of anthranilate synthase
B9G99_RS00170	COG4695	Portal protein
B9G99_RS00175	COG1802	Transcriptional regulator
B9G99_RS00175	COG4626	Terminase
B9G99_RS00255	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B9G99_RS00300	COG2974	May be involved in recombination
B9G99_RS00335	COG0582	viral genome integration into host DNA
B9G99_RS00345	COG0546	phosphoglycolate phosphatase activity
B9G99_RS00350	COG1252	NADH dehydrogenase
B9G99_RS00360	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B9G99_RS00370	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B9G99_RS00380	COG0405	Gamma-glutamyltransferase
B9G99_RS00395	COG4208	sulfate ABC transporter
B9G99_RS00400	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B9G99_RS00405	COG0500	methyltransferase
B9G99_RS00410	COG4991	sh3 domain protein
B9G99_RS00420	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B9G99_RS00425	COG1702	phosphate starvation-inducible protein PhoH
B9G99_RS00430	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B9G99_RS00435	COG4535	Mg2 and Co2 transporter CorC
B9G99_RS00440	COG0815	Transfers the fatty acyl group on membrane lipoproteins
B9G99_RS00460	COG0495	leucyl-tRNA aminoacylation
B9G99_RS00485	COG0589	response to stress
B9G99_RS00490	COG0488	(ABC) transporter
B9G99_RS00505	COG3101	peptidyl-lysine hydroxylation
B9G99_RS00525	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
B9G99_RS00555	COG1802	Transcriptional regulator
B9G99_RS00565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B9G99_RS00585	COG0730	response to heat
B9G99_RS00595	COG0628	permease
B9G99_RS00600	COG2814	Major facilitator Superfamily
B9G99_RS00615	COG2853	Lipoprotein
B9G99_RS00620	COG1643	Atp-dependent helicase
B9G99_RS00630	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B9G99_RS00635	COG0121	glutamine amidotransferase
B9G99_RS00655	COG2983	Belongs to the UPF0260 family
B9G99_RS00670	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B9G99_RS00675	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B9G99_RS00680	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B9G99_RS00695	COG0642	Histidine kinase
B9G99_RS00705	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
B9G99_RS00710	COG1196	nuclear chromosome segregation
B9G99_RS00710	COG3264	Mechanosensitive ion channel
B9G99_RS00720	COG4575	ribosome binding
B9G99_RS00725	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
B9G99_RS00735	COG2081	HI0933 family
B9G99_RS00740	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
B9G99_RS00755	COG0778	Nitroreductase
B9G99_RS00760	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B9G99_RS00760	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B9G99_RS00765	COG0842	Transport permease protein
B9G99_RS00770	COG1131	(ABC) transporter
B9G99_RS00805	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B9G99_RS00810	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B9G99_RS00815	COG0436	Aminotransferase
B9G99_RS00820	COG0501	Belongs to the peptidase M48B family
B9G99_RS00825	COG1309	transcriptional regulator
B9G99_RS00835	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B9G99_RS00845	COG0116	Belongs to the methyltransferase superfamily
B9G99_RS00845	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B9G99_RS00850	COG3130	regulation of translation
B9G99_RS00855	COG0167	dihydroorotate dehydrogenase activity
B9G99_RS00870	COG2902	Dehydrogenase
B9G99_RS00875	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B9G99_RS00890	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B9G99_RS00895	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
B9G99_RS00900	COG1674	ftsk spoiiie
B9G99_RS00905	COG1674	ftsk spoiiie
B9G99_RS00905	COG3107	peptidoglycan biosynthetic process
B9G99_RS00910	COG0840	transmembrane signaling receptor activity
B9G99_RS00915	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
B9G99_RS00920	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
B9G99_RS00925	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B9G99_RS00930	COG0542	response to heat
B9G99_RS00935	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
B9G99_RS00945	COG1187	pseudouridine synthase activity
B9G99_RS00955	COG0482	sulfurtransferase activity
B9G99_RS00960	COG2915	High frequency lysogenization protein hflD homolog
B9G99_RS00970	COG2850	peptidyl-arginine hydroxylation
B9G99_RS00980	COG3133	Outer membrane lipoprotein
B9G99_RS01010	COG0189	ligase activity
B9G99_RS01010	COG4067	protein conserved in archaea
B9G99_RS01015	COG0189	ligase activity
B9G99_RS01035	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B9G99_RS01040	COG0719	Fe-S assembly protein
B9G99_RS01045	COG0396	ATPase activity
B9G99_RS01050	COG0719	Fe-S assembly protein
B9G99_RS01055	COG1959	2 iron, 2 sulfur cluster binding
B9G99_RS01060	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B9G99_RS01065	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
B9G99_RS01070	COG0330	HflC and HflK could
B9G99_RS01075	COG0330	HflC and HflK could
B9G99_RS01080	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B9G99_RS01085	COG1923	regulation of RNA biosynthetic process
B9G99_RS01090	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B9G99_RS01095	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B9G99_RS01105	COG0802	atpase or kinase
B9G99_RS01110	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B9G99_RS01110	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B9G99_RS01120	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
B9G99_RS01125	COG1162	GTPase activity
B9G99_RS01130	COG2252	PERMEase
B9G99_RS01140	COG0688	phosphatidylethanolamine metabolic process
B9G99_RS01155	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B9G99_RS01160	COG1509	lysine 2,3-aminomutase activity
B9G99_RS01175	COG2951	lytic endotransglycosylase activity
B9G99_RS01210	COG3150	esterase
B9G99_RS01215	COG0166	Belongs to the GPI family
B9G99_RS01220	COG4106	trans-aconitate 2-methyltransferase activity
B9G99_RS01225	COG0500	methyltransferase
B9G99_RS01235	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B9G99_RS01240	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
B9G99_RS01250	COG2895	sulfate adenylyltransferase (ATP) activity
B9G99_RS01255	COG0175	sulfate reduction
B9G99_RS01260	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B9G99_RS01270	COG0494	nUDIX hydrolase
B9G99_RS01275	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B9G99_RS01280	COG2813	Specifically methylates the guanine in position
B9G99_RS01285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B9G99_RS01295	COG0456	acetyltransferase
B9G99_RS01300	COG0583	DNA-binding transcription factor activity
B9G99_RS01305	COG2828	Protein conserved in bacteria
B9G99_RS01320	COG4763	Acyl-transferase
B9G99_RS01330	COG0546	phosphoglycolate phosphatase activity
B9G99_RS01335	COG2814	Major facilitator Superfamily
B9G99_RS01340	COG2807	transmembrane transport
B9G99_RS01350	COG1748	Saccharopine dehydrogenase
B9G99_RS01370	COG0840	transmembrane signaling receptor activity
B9G99_RS01375	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
B9G99_RS01420	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B9G99_RS01425	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B9G99_RS01430	COG3852	Histidine kinase
B9G99_RS01435	COG2204	response regulator
B9G99_RS01445	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
B9G99_RS01450	COG0494	nUDIX hydrolase
B9G99_RS01460	COG0579	oxidoreductase
B9G99_RS01465	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B9G99_RS01475	COG2183	response to ionizing radiation
B9G99_RS01480	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
B9G99_RS01485	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B9G99_RS01490	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B9G99_RS01495	COG0494	nUDIX hydrolase
B9G99_RS01505	COG1442	glycosyl transferase family 8
B9G99_RS01510	COG0438	transferase activity, transferring glycosyl groups
B9G99_RS01525	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B9G99_RS01535	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B9G99_RS01540	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B9G99_RS01545	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B9G99_RS01550	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B9G99_RS01560	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B9G99_RS01560	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B9G99_RS01565	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B9G99_RS01575	COG2261	transglycosylase associated protein
B9G99_RS01595	COG3246	L-lysine catabolic process to acetate
B9G99_RS01605	COG0366	Alpha amylase catalytic
B9G99_RS01615	COG1785	Belongs to the alkaline phosphatase family
B9G99_RS01620	COG1215	transferase activity, transferring glycosyl groups
B9G99_RS01640	COG0579	oxidoreductase
B9G99_RS01670	COG2089	acid synthase
B9G99_RS01675	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B9G99_RS01685	COG1083	cytidylyl-transferase
B9G99_RS01690	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B9G99_RS01695	COG1086	Polysaccharide biosynthesis protein
B9G99_RS01710	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B9G99_RS01725	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
B9G99_RS01730	COG4181	ATPase activity
B9G99_RS01750	COG1366	Belongs to the anti-sigma-factor antagonist family
B9G99_RS01760	COG0488	(ABC) transporter
B9G99_RS01765	COG1560	Kdo2-lipid A biosynthetic process
B9G99_RS01770	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B9G99_RS01775	COG1538	Outer membrane efflux protein
B9G99_RS01785	COG1388	LysM domain
B9G99_RS01785	COG4942	peptidase
B9G99_RS01795	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
B9G99_RS01800	COG0585	pseudouridine synthase activity
B9G99_RS01805	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B9G99_RS01810	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B9G99_RS01815	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
B9G99_RS01820	COG0494	nUDIX hydrolase
B9G99_RS01825	COG0494	nUDIX hydrolase
B9G99_RS01860	COG1666	GTP binding
B9G99_RS01865	COG0583	DNA-binding transcription factor activity
B9G99_RS01870	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
B9G99_RS01880	COG1473	amidohydrolase
B9G99_RS01895	COG2814	Major facilitator Superfamily
B9G99_RS01900	COG0583	DNA-binding transcription factor activity
B9G99_RS01910	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
B9G99_RS01930	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B9G99_RS01945	COG0679	Auxin Efflux Carrier
B9G99_RS01950	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B9G99_RS01955	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B9G99_RS01975	COG1295	ribonuclease BN
B9G99_RS02000	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B9G99_RS02005	COG0366	Alpha amylase catalytic
B9G99_RS02030	COG1640	4-alpha-glucanotransferase
B9G99_RS02035	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B9G99_RS02040	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B9G99_RS02045	COG0297	glycogen (starch) synthase activity
B9G99_RS02050	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B9G99_RS02055	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B9G99_RS02060	COG1121	(ABC) transporter
B9G99_RS02065	COG0803	Belongs to the bacterial solute-binding protein 9 family
B9G99_RS02075	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
B9G99_RS02080	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
B9G99_RS02090	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B9G99_RS02120	COG0837	glucose binding
B9G99_RS02125	COG0676	glucose-6-phosphate 1-epimerase activity
B9G99_RS02150	COG2814	Major facilitator Superfamily
B9G99_RS02155	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
B9G99_RS02160	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B9G99_RS02160	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
B9G99_RS02180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B9G99_RS02190	COG0204	Acyl-transferase
B9G99_RS02190	COG0318	PFAM AMP-dependent synthetase and ligase
B9G99_RS02225	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B9G99_RS02235	COG1028	Short-chain dehydrogenase reductase Sdr
B9G99_RS02255	COG0659	secondary active sulfate transmembrane transporter activity
B9G99_RS02260	COG2353	YceI-like domain
B9G99_RS02265	COG0330	HflC and HflK could
B9G99_RS02280	COG1312	Catalyzes the dehydration of D-mannonate
B9G99_RS02285	COG0246	Mannitol dehydrogenase
B9G99_RS02290	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B9G99_RS02300	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B9G99_RS02305	COG4948	Mandelate Racemase Muconate Lactonizing
B9G99_RS02310	COG2186	Transcriptional regulator
B9G99_RS02320	COG0783	Belongs to the Dps family
B9G99_RS02330	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B9G99_RS02335	COG3416	Protein conserved in bacteria
B9G99_RS02345	COG3015	lipoprotein NlpE involved in copper resistance
B9G99_RS02355	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B9G99_RS02360	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B9G99_RS02365	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B9G99_RS02380	COG2423	ornithine cyclodeaminase activity
B9G99_RS02385	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B9G99_RS02390	COG1012	belongs to the aldehyde dehydrogenase family
B9G99_RS02395	COG1732	Glycine betaine
B9G99_RS02400	COG1174	glycine betaine transport
B9G99_RS02405	COG1174	glycine betaine transport
B9G99_RS02425	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
B9G99_RS02430	COG2233	PERMEase
B9G99_RS02435	COG1309	transcriptional regulator
B9G99_RS02450	COG0493	'glutamate synthase
B9G99_RS02455	COG0070	glutamate synthase
B9G99_RS02455	COG0067	glutamate synthase
B9G99_RS02455	COG0069	glutamate synthase activity
B9G99_RS02460	COG2851	Citrate transporter
B9G99_RS02465	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B9G99_RS02470	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B9G99_RS02520	COG0281	malic enzyme
B9G99_RS02525	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B9G99_RS02530	COG0018	arginyl-trna synthetase
B9G99_RS02540	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B9G99_RS02545	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
B9G99_RS02555	COG2226	methyltransferase
B9G99_RS02565	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B9G99_RS02570	COG0140	phosphoribosyl-ATP diphosphatase activity
B9G99_RS02575	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B9G99_RS02580	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B9G99_RS02610	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B9G99_RS02615	COG1028	Short-chain dehydrogenase reductase Sdr
B9G99_RS02620	COG0543	2 iron, 2 sulfur cluster binding
B9G99_RS02620	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B9G99_RS02625	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
B9G99_RS02640	COG0248	Ppx GppA phosphatase
B9G99_RS02645	COG0037	tRNA processing
B9G99_RS02655	COG0587	DNA-directed DNA polymerase activity
B9G99_RS02660	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B9G99_RS02665	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B9G99_RS02670	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B9G99_RS02675	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B9G99_RS02680	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B9G99_RS02690	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B9G99_RS02710	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B9G99_RS02715	COG0233	cytoplasmic translational termination
B9G99_RS02720	COG0528	UMP kinase activity
B9G99_RS02725	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B9G99_RS02730	COG0052	Belongs to the universal ribosomal protein uS2 family
B9G99_RS02745	COG1393	Belongs to the ArsC family
B9G99_RS02755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B9G99_RS02770	COG2900	Belongs to the SlyX family
B9G99_RS02775	COG0492	ferredoxin-NADP+ reductase activity
B9G99_RS02795	COG2391	methyltransferase activity
B9G99_RS02805	COG0180	Tryptophanyl-tRNA synthetase
B9G99_RS02820	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B9G99_RS02825	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B9G99_RS02830	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B9G99_RS02835	COG2003	Belongs to the UPF0758 family
B9G99_RS02840	COG1063	alcohol dehydrogenase
B9G99_RS02850	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B9G99_RS02855	COG0756	dUTP diphosphatase activity
B9G99_RS02865	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B9G99_RS02870	COG1309	transcriptional regulator
B9G99_RS02875	COG2200	EAL domain
B9G99_RS02875	COG2202	Pas domain
B9G99_RS02875	COG2199	diguanylate cyclase activity
B9G99_RS02885	COG2177	Part of the ABC transporter FtsEX involved in
B9G99_RS02890	COG2884	Cell division ATP-binding protein ftsE
B9G99_RS02895	COG0552	protein localization to endoplasmic reticulum
B9G99_RS02900	COG0742	ribosomal rna small subunit methyltransferase
B9G99_RS02915	COG0271	Belongs to the BolA IbaG family
B9G99_RS02930	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B9G99_RS02940	COG4166	transmembrane transport
B9G99_RS02950	COG4166	transmembrane transport
B9G99_RS02960	COG0601	transmembrane transport
B9G99_RS02965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B9G99_RS02970	COG4172	Belongs to the ABC transporter superfamily
B9G99_RS02980	COG1595	DNA-templated transcription, initiation
B9G99_RS02995	COG2217	Heavy metal translocating P-type atpase
B9G99_RS03000	COG0346	lactoylglutathione lyase activity
B9G99_RS03010	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B9G99_RS03015	COG0625	glutathione transferase activity
B9G99_RS03030	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B9G99_RS03040	COG0335	large ribosomal subunit rRNA binding
B9G99_RS03045	COG0336	Belongs to the RNA methyltransferase TrmD family
B9G99_RS03050	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B9G99_RS03055	COG0228	four-way junction DNA binding
B9G99_RS03060	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B9G99_RS03065	COG4137	Cytochrome C assembly protein
B9G99_RS03070	COG4536	flavin adenine dinucleotide binding
B9G99_RS03110	COG2925	Exonuclease
B9G99_RS03115	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
B9G99_RS03120	COG2894	cell division
B9G99_RS03125	COG0850	regulation of cytokinetic process
B9G99_RS03145	COG3118	belongs to the thioredoxin family
B9G99_RS03150	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B9G99_RS03185	COG0667	Aldo Keto reductase
B9G99_RS03190	COG3022	response to hydroperoxide
B9G99_RS03220	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B9G99_RS03230	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B9G99_RS03250	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B9G99_RS03260	COG0573	inorganic phosphate transmembrane transporter activity
B9G99_RS03265	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B9G99_RS03270	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B9G99_RS03280	COG2996	Protein conserved in bacteria
B9G99_RS03295	COG2814	Major facilitator Superfamily
B9G99_RS03300	COG1072	(Pantothenic acid kinase))
B9G99_RS03305	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B9G99_RS03310	COG1070	Carbohydrate kinase
B9G99_RS03315	COG0246	Mannitol dehydrogenase
B9G99_RS03320	COG3842	ATPase activity
B9G99_RS03330	COG1175	transmembrane transport
B9G99_RS03345	COG0668	transmembrane transport
B9G99_RS03350	COG0254	rRNA binding
B9G99_RS03360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B9G99_RS03390	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B9G99_RS03405	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B9G99_RS03410	COG1090	epimerase
B9G99_RS03415	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
B9G99_RS03420	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B9G99_RS03425	COG0789	Transcriptional regulator
B9G99_RS03435	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B9G99_RS03465	COG0629	single-stranded DNA binding
B9G99_RS03475	COG2200	EAL domain
B9G99_RS03480	COG0203	ribosomal protein L17
B9G99_RS03485	COG0202	RNA polymerase activity
B9G99_RS03490	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B9G99_RS03495	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B9G99_RS03500	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B9G99_RS03510	COG0200	Binds to the 23S rRNA
B9G99_RS03515	COG1841	ribosomal large subunit assembly
B9G99_RS03520	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B9G99_RS03525	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B9G99_RS03530	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B9G99_RS03535	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B9G99_RS03540	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B9G99_RS03545	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B9G99_RS03550	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B9G99_RS03555	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B9G99_RS03560	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B9G99_RS03565	COG0255	Belongs to the universal ribosomal protein uL29 family
B9G99_RS03570	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B9G99_RS03575	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B9G99_RS03580	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B9G99_RS03585	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B9G99_RS03595	COG0089	rRNA binding
B9G99_RS03600	COG0088	Forms part of the polypeptide exit tunnel
B9G99_RS03605	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B9G99_RS03610	COG0051	transcription antitermination factor activity, RNA binding
B9G99_RS03615	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B9G99_RS03620	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B9G99_RS03625	COG0049	tRNA binding
B9G99_RS03630	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B9G99_RS03635	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B9G99_RS03640	COG0085	RNA polymerase activity
B9G99_RS03645	COG0222	ribosome binding
B9G99_RS03650	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B9G99_RS03655	COG0081	regulation of translation
B9G99_RS03660	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B9G99_RS03695	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B9G99_RS03700	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
B9G99_RS03700	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
B9G99_RS03705	COG1294	oxidase, subunit
B9G99_RS03710	COG1271	oxidase subunit
B9G99_RS03715	COG0109	protoheme IX farnesyltransferase activity
B9G99_RS03720	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B9G99_RS03725	COG1845	cytochrome c oxidase, subunit III
B9G99_RS03735	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B9G99_RS03770	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B9G99_RS03775	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
B9G99_RS03805	COG2813	Specifically methylates the guanine in position
B9G99_RS03805	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B9G99_RS03815	COG1489	DNA binding
B9G99_RS03820	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B9G99_RS03825	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B9G99_RS03840	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B9G99_RS03845	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B9G99_RS03855	COG1185	polyribonucleotide nucleotidyltransferase activity
B9G99_RS03860	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B9G99_RS03865	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B9G99_RS03870	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B9G99_RS03875	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B9G99_RS03880	COG0195	Participates in both transcription termination and antitermination
B9G99_RS03880	COG2251	uridine kinase activity
B9G99_RS03885	COG0779	Required for maturation of 30S ribosomal subunits
B9G99_RS03905	COG0149	triose-phosphate isomerase activity
B9G99_RS03910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B9G99_RS03915	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B9G99_RS03920	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B9G99_RS03950	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B9G99_RS03975	COG3383	formate dehydrogenase (NAD+) activity
B9G99_RS03990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B9G99_RS03995	COG1120	ATPase activity
B9G99_RS04000	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B9G99_RS04005	COG1764	response to oxidative stress
B9G99_RS04010	COG0484	heat shock protein binding
B9G99_RS04015	COG0443	Heat shock 70 kDa protein
B9G99_RS04020	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B9G99_RS04025	COG0497	DNA recombination
B9G99_RS04035	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B9G99_RS04040	COG2914	Belongs to the UPF0125 (RnfH) family
B9G99_RS04045	COG2867	negative regulation of translational initiation
B9G99_RS04050	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B9G99_RS04075	COG1278	Cold shock
B9G99_RS04095	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
B9G99_RS04100	COG1194	a g-specific adenine glycosylase
B9G99_RS04110	COG0131	Imidazoleglycerol-phosphate dehydratase
B9G99_RS04115	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B9G99_RS04120	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B9G99_RS04125	COG0107	imidazoleglycerol-phosphate synthase activity
B9G99_RS04130	COG3068	Protein conserved in bacteria
B9G99_RS04135	COG3695	enzyme binding
B9G99_RS04140	COG0519	Catalyzes the synthesis of GMP from XMP
B9G99_RS04140	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B9G99_RS04145	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
B9G99_RS04150	COG0709	Synthesizes selenophosphate from selenide and ATP
B9G99_RS04155	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
B9G99_RS04165	COG1902	pentaerythritol trinitrate reductase activity
B9G99_RS04175	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B9G99_RS04205	COG1011	Hydrolase
B9G99_RS04215	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B9G99_RS04220	COG0733	neurotransmitter:sodium symporter activity
B9G99_RS04225	COG0339	signal peptide processing
B9G99_RS04235	COG2032	superoxide dismutase activity
B9G99_RS04240	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B9G99_RS04245	COG3276	selenocysteine insertion sequence binding
B9G99_RS04250	COG1921	L-seryl-tRNASec selenium transferase activity
B9G99_RS04260	COG2864	formate dehydrogenase
B9G99_RS04265	COG0437	4 iron, 4 sulfur cluster binding
B9G99_RS04270	COG3383	formate dehydrogenase (NAD+) activity
B9G99_RS04270	COG0243	molybdopterin cofactor binding
B9G99_RS04275	COG0243	molybdopterin cofactor binding
B9G99_RS04275	COG3383	formate dehydrogenase (NAD+) activity
B9G99_RS04290	COG1796	DNA polymerase
B9G99_RS04290	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B9G99_RS04300	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B9G99_RS04310	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B9G99_RS04320	COG1063	alcohol dehydrogenase
B9G99_RS04325	COG1879	ABC-type sugar transport system periplasmic component
B9G99_RS04330	COG1172	Belongs to the binding-protein-dependent transport system permease family
B9G99_RS04335	COG1129	ABC transporter
B9G99_RS04350	COG1028	Short-chain dehydrogenase reductase Sdr
B9G99_RS04360	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B9G99_RS04365	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B9G99_RS04370	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B9G99_RS04380	COG0698	ribose 5-phosphate isomerase
B9G99_RS04385	COG2376	Dihydroxyacetone kinase
B9G99_RS04390	COG0149	triose-phosphate isomerase activity
B9G99_RS04395	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B9G99_RS04400	COG1830	Aldolase
B9G99_RS04405	COG0126	phosphoglycerate kinase activity
B9G99_RS04415	COG0840	transmembrane signaling receptor activity
B9G99_RS04430	COG0673	inositol 2-dehydrogenase activity
B9G99_RS04435	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
B9G99_RS04440	COG0803	Belongs to the bacterial solute-binding protein 9 family
B9G99_RS04465	COG0400	carboxylic ester hydrolase activity
B9G99_RS04470	COG0583	DNA-binding transcription factor activity
B9G99_RS04485	COG2851	Citrate transporter
B9G99_RS04510	COG4145	pantothenate transmembrane transporter activity
B9G99_RS04520	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B9G99_RS04525	COG2207	Transcriptional regulator
B9G99_RS04550	COG0625	glutathione transferase activity
B9G99_RS04575	COG1704	LemA family
B9G99_RS04580	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
B9G99_RS04615	COG0697	spore germination
B9G99_RS04620	COG1609	Transcriptional regulator
B9G99_RS04625	COG2211	Major facilitator Superfamily
B9G99_RS04630	COG1472	Belongs to the glycosyl hydrolase 3 family
B9G99_RS04645	COG0673	inositol 2-dehydrogenase activity
B9G99_RS04650	COG3706	GGDEF domain
B9G99_RS04660	COG0023	Translation Initiation Factor
B9G99_RS04670	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B9G99_RS04680	COG2223	nitrite transmembrane transporter activity
B9G99_RS04685	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B9G99_RS04690	COG1609	Transcriptional regulator
B9G99_RS04695	COG0366	Alpha amylase catalytic
B9G99_RS04700	COG1653	transport
B9G99_RS04705	COG3842	ATPase activity
B9G99_RS04720	COG1653	transport
B9G99_RS04735	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B9G99_RS04740	COG1609	Transcriptional regulator
B9G99_RS04745	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B9G99_RS04750	COG1914	H( )-stimulated, divalent metal cation uptake system
B9G99_RS04765	COG3852	Histidine kinase
B9G99_RS04780	COG1217	gtp-binding protein TYPA
B9G99_RS04790	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B9G99_RS04800	COG0450	alkyl hydroperoxide reductase
B9G99_RS04805	COG0655	NAD(P)H dehydrogenase (quinone) activity
B9G99_RS04815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B9G99_RS04825	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B9G99_RS04845	COG2188	Transcriptional regulator
B9G99_RS04850	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
B9G99_RS04855	COG0589	response to stress
B9G99_RS04860	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B9G99_RS04865	COG0110	maltose O-acetyltransferase activity
B9G99_RS04875	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B9G99_RS04890	COG1012	belongs to the aldehyde dehydrogenase family
B9G99_RS04935	COG4115	mRNA cleavage
B9G99_RS04940	COG2161	toxin-antitoxin pair type II binding
B9G99_RS04950	COG4773	Receptor
B9G99_RS04960	COG0156	8-amino-7-oxononanoate synthase activity
B9G99_RS04965	COG0596	Alpha beta hydrolase
B9G99_RS04970	COG2226	methyltransferase
B9G99_RS04985	COG3158	transport of potassium into the cell
B9G99_RS04995	COG2329	Antibiotic biosynthesis monooxygenase
B9G99_RS05015	COG2031	fatty acid transporter
B9G99_RS05040	COG1473	amidohydrolase
B9G99_RS05045	COG3300	MHYT domain
B9G99_RS05045	COG5001	Diguanylate cyclase
B9G99_RS05050	COG1289	transmembrane transporter activity
B9G99_RS05055	COG2249	NAD(P)H dehydrogenase (quinone) activity
B9G99_RS05060	COG0583	DNA-binding transcription factor activity
B9G99_RS05075	COG4948	Mandelate Racemase Muconate Lactonizing
B9G99_RS05080	COG0800	Aldolase
B9G99_RS05085	COG3734	2-keto-3-deoxy-galactonokinase
B9G99_RS05090	COG1414	Transcriptional regulator
B9G99_RS05095	COG0668	transmembrane transport
B9G99_RS05105	COG2153	protein acetylation
B9G99_RS05110	COG0625	glutathione transferase activity
B9G99_RS05115	COG1280	lysine exporter protein (LysE YggA)
B9G99_RS05120	COG1363	Peptidase, m42
B9G99_RS05125	COG2031	fatty acid transporter
B9G99_RS05130	COG3047	cAMP biosynthetic process
B9G99_RS05135	COG3103	Sh3 type 3 domain protein
B9G99_RS05135	COG1388	LysM domain
B9G99_RS05135	COG0791	NLP P60 protein
B9G99_RS05150	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B9G99_RS05155	COG3485	protocatechuate 3,4-dioxygenase
B9G99_RS05160	COG3485	protocatechuate 3,4-dioxygenase
B9G99_RS05165	COG3185	4-Hydroxyphenylpyruvate dioxygenase
B9G99_RS05165	COG1082	Xylose isomerase domain protein TIM barrel
B9G99_RS05185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B9G99_RS05205	COG1129	ABC transporter
B9G99_RS05215	COG0477	Major facilitator Superfamily
B9G99_RS05225	COG1846	Transcriptional regulator
B9G99_RS05225	COG1940	carbohydrate kinase activity
B9G99_RS05230	COG0574	Belongs to the PEP-utilizing enzyme family
B9G99_RS05230	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B9G99_RS05235	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B9G99_RS05255	COG0252	asparaginase activity
B9G99_RS05280	COG1864	DNA RNA non-specific endonuclease
B9G99_RS05280	COG3591	Belongs to the peptidase S1B family
B9G99_RS05285	COG5001	Diguanylate cyclase
B9G99_RS05320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B9G99_RS05350	COG0437	4 iron, 4 sulfur cluster binding
B9G99_RS05385	COG0300	oxidoreductase activity
B9G99_RS05390	COG1741	Belongs to the pirin family
B9G99_RS05410	COG0531	amino acid
B9G99_RS05420	COG3842	ATPase activity
B9G99_RS05425	COG0395	ABC-type sugar transport system, permease component
B9G99_RS05430	COG1175	transmembrane transport
B9G99_RS05435	COG1653	transport
B9G99_RS05455	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B9G99_RS05465	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B9G99_RS05470	COG0592	DNA-directed DNA polymerase activity
B9G99_RS05475	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B9G99_RS05480	COG0230	Belongs to the bacterial ribosomal protein bL34 family
B9G99_RS05485	COG0594	ribonuclease P activity
B9G99_RS05490	COG0706	membrane insertase activity
B9G99_RS05530	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B9G99_RS05540	COG2814	Major facilitator Superfamily
B9G99_RS05550	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B9G99_RS05555	COG1132	(ABC) transporter
B9G99_RS05560	COG1132	(ABC) transporter
B9G99_RS05565	COG2995	paraquat-inducible protein a
B9G99_RS05570	COG3008	intermembrane lipid transfer
B9G99_RS05570	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B9G99_RS05575	COG3009	Protein conserved in bacteria
B9G99_RS05580	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
B9G99_RS05585	COG2885	chlorophyll binding
B9G99_RS05590	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B9G99_RS05605	COG0659	secondary active sulfate transmembrane transporter activity
B9G99_RS05610	COG0288	reversible hydration of carbon dioxide
B9G99_RS05625	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B9G99_RS05630	COG0352	thiamine-phosphate diphosphorylase activity
B9G99_RS05640	COG1981	membrane
B9G99_RS05650	COG0316	Belongs to the HesB IscA family
B9G99_RS05655	COG0445	tRNA wobble uridine modification
B9G99_RS05660	COG0357	Ribosomal RNA small subunit methyltransferase G
B9G99_RS05665	COG1192	Involved in chromosome partitioning
B9G99_RS05670	COG1475	DNA binding
B9G99_RS05675	COG3312	ion transport
B9G99_RS05680	COG0356	it plays a direct role in the translocation of protons across the membrane
B9G99_RS05690	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B9G99_RS05695	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B9G99_RS05700	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B9G99_RS05705	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B9G99_RS05710	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B9G99_RS05715	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B9G99_RS05720	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B9G99_RS05725	COG1349	DNA-binding transcription factor activity
B9G99_RS05740	COG4993	Dehydrogenase
B9G99_RS05745	COG2982	Protein involved in outer membrane biogenesis
B9G99_RS05750	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
B9G99_RS05755	COG1801	Protein of unknown function DUF72
B9G99_RS05760	COG0733	neurotransmitter:sodium symporter activity
B9G99_RS05780	COG1737	Transcriptional regulator
B9G99_RS05785	COG0210	DNA helicase
B9G99_RS05790	COG0704	Plays a role in the regulation of phosphate uptake
B9G99_RS05795	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
B9G99_RS05800	COG3023	N-Acetylmuramoyl-L-alanine amidase
B9G99_RS05815	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B9G99_RS05830	COG0159	tryptophan synthase activity
B9G99_RS05845	COG1917	Cupin 2, conserved barrel domain protein
B9G99_RS05845	COG2207	Transcriptional regulator
B9G99_RS05860	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B9G99_RS05865	COG0583	DNA-binding transcription factor activity
B9G99_RS05880	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B9G99_RS05885	COG1758	RNA polymerase activity
B9G99_RS05890	COG0194	GDP metabolic process
B9G99_RS05895	COG2999	glutathione oxidoreductase activity
B9G99_RS05905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B9G99_RS05925	COG1140	nitrate reductase beta subunit
B9G99_RS05940	COG4772	TonB-dependent receptor
B9G99_RS05945	COG0444	Belongs to the ABC transporter superfamily
B9G99_RS05955	COG0747	negative chemotaxis
B9G99_RS05965	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B9G99_RS05970	COG1028	Short-chain dehydrogenase reductase Sdr
B9G99_RS05980	COG3604	Transcriptional regulator
B9G99_RS05985	COG0583	DNA-binding transcription factor activity
B9G99_RS05990	COG1028	Short-chain dehydrogenase reductase Sdr
B9G99_RS05995	COG1764	response to oxidative stress
B9G99_RS06000	COG1846	Transcriptional regulator
B9G99_RS06005	COG0483	inositol monophosphate 1-phosphatase activity
B9G99_RS06015	COG0640	Transcriptional regulator
B9G99_RS06045	COG0270	DNA (cytosine-5-)-methyltransferase activity
B9G99_RS06050	COG4993	Dehydrogenase
B9G99_RS06065	COG0604	alcohol dehydrogenase
B9G99_RS06070	COG1309	transcriptional regulator
B9G99_RS06075	COG3453	Protein conserved in bacteria
B9G99_RS06075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B9G99_RS06095	COG2351	hydroxyisourate hydrolase activity
B9G99_RS06120	COG0583	DNA-binding transcription factor activity
B9G99_RS06125	COG1012	belongs to the aldehyde dehydrogenase family
B9G99_RS06135	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B9G99_RS06150	COG0251	oxidation-reduction process
B9G99_RS06155	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B9G99_RS06165	COG0583	DNA-binding transcription factor activity
B9G99_RS06175	COG0583	DNA-binding transcription factor activity
B9G99_RS06185	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B9G99_RS06195	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B9G99_RS06205	COG1346	cytolysis
B9G99_RS06210	COG2207	Transcriptional regulator
B9G99_RS06210	COG3708	Transcriptional regulator
B9G99_RS06215	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B9G99_RS06255	COG0582	viral genome integration into host DNA
B9G99_RS06260	COG1561	YicC-like family, N-terminal region
B9G99_RS06265	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B9G99_RS06270	COG0708	Exodeoxyribonuclease III
B9G99_RS06285	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B9G99_RS06290	COG0454	-acetyltransferase
B9G99_RS06305	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
B9G99_RS06345	COG1233	COG1233 Phytoene dehydrogenase and related
B9G99_RS06350	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
B9G99_RS06395	COG0488	(ABC) transporter
B9G99_RS06410	COG1187	pseudouridine synthase activity
B9G99_RS06425	COG0840	transmembrane signaling receptor activity
B9G99_RS06430	COG1278	Cold shock
B9G99_RS06435	COG0686	Belongs to the AlaDH PNT family
B9G99_RS06440	COG2205	protein histidine kinase activity
B9G99_RS06445	COG0745	RESPONSE REGULATOR receiver
B9G99_RS06460	COG0778	Nitroreductase
B9G99_RS06475	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B9G99_RS06480	COG1418	mRNA catabolic process
B9G99_RS06485	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B9G99_RS06500	COG1971	Probably functions as a manganese efflux pump
B9G99_RS06505	COG2824	Alkylphosphonate utilization operon protein PhnA
B9G99_RS06510	COG0833	amino acid
B9G99_RS06515	COG2040	homocysteine
B9G99_RS06530	COG1620	l-lactate permease
B9G99_RS06535	COG2186	Transcriptional regulator
B9G99_RS06540	COG1288	antiporter activity
B9G99_RS06545	COG0730	response to heat
B9G99_RS06550	COG3387	PFAM Glycoside hydrolase 15-related
B9G99_RS06555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B9G99_RS06560	COG2133	pyrroloquinoline quinone binding
B9G99_RS06570	COG1028	Short-chain dehydrogenase reductase Sdr
B9G99_RS06580	COG4993	Dehydrogenase
B9G99_RS06590	COG1280	lysine exporter protein (LysE YggA)
B9G99_RS06595	COG4763	Acyl-transferase
B9G99_RS06625	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B9G99_RS06630	COG1802	Transcriptional regulator
B9G99_RS06635	COG1120	ATPase activity
B9G99_RS06640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B9G99_RS06650	COG2814	Major facilitator Superfamily
B9G99_RS06655	COG0436	Aminotransferase
B9G99_RS06665	COG2610	gluconate transmembrane transporter activity
B9G99_RS06675	COG1250	3-hydroxyacyl-CoA dehydrogenase
B9G99_RS06680	COG0454	-acetyltransferase
B9G99_RS06685	COG1012	belongs to the aldehyde dehydrogenase family
B9G99_RS06690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B9G99_RS06710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B9G99_RS06720	COG1522	sequence-specific DNA binding
B9G99_RS06730	COG4770	biotin carboxylase activity
B9G99_RS06740	COG4336	lyase activity
B9G99_RS06745	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B9G99_RS06750	COG1914	H( )-stimulated, divalent metal cation uptake system
B9G99_RS06755	COG1802	Transcriptional regulator
B9G99_RS06765	COG0653	protein targeting
B9G99_RS06775	COG2733	membrane
B9G99_RS06785	COG0513	Belongs to the DEAD box helicase family
B9G99_RS06790	COG0477	Major facilitator Superfamily
B9G99_RS06820	COG5001	Diguanylate cyclase
B9G99_RS06825	COG5001	Diguanylate cyclase
B9G99_RS06825	COG5002	protein histidine kinase activity
B9G99_RS06835	COG1902	pentaerythritol trinitrate reductase activity
B9G99_RS06850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B9G99_RS06865	COG2814	Major facilitator Superfamily
B9G99_RS06870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B9G99_RS06875	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B9G99_RS06880	COG0583	DNA-binding transcription factor activity
B9G99_RS06890	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B9G99_RS06895	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B9G99_RS06905	COG0751	glycine-tRNA ligase activity
B9G99_RS06910	COG0752	glycyl-tRNA synthetase alpha subunit
B9G99_RS06915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B9G99_RS06920	COG0859	PFAM glycosyl transferase family 9
B9G99_RS06925	COG1280	lysine exporter protein (LysE YggA)
B9G99_RS06930	COG1181	Belongs to the D-alanine--D-alanine ligase family
B9G99_RS06935	COG0297	glycogen (starch) synthase activity
B9G99_RS06940	COG0463	Glycosyl transferase, family 2
B9G99_RS06950	COG3642	lipopolysaccharide core region biosynthetic process
B9G99_RS06955	COG0859	PFAM glycosyl transferase family 9
B9G99_RS06960	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B9G99_RS06960	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B9G99_RS06965	COG1519	Transferase
B9G99_RS06975	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
B9G99_RS06980	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B9G99_RS06985	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B9G99_RS07005	COG0006	proline dipeptidase activity
B9G99_RS07010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B9G99_RS07015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B9G99_RS07025	COG0793	Belongs to the peptidase S41A family
B9G99_RS07030	COG4942	peptidase
B9G99_RS07035	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
B9G99_RS07040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B9G99_RS07045	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
B9G99_RS07050	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B9G99_RS07055	COG0028	Belongs to the TPP enzyme family
B9G99_RS07060	COG1902	pentaerythritol trinitrate reductase activity
B9G99_RS07065	COG0189	ligase activity
B9G99_RS07070	COG1678	Uncharacterized ACR, COG1678
B9G99_RS07075	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B9G99_RS07080	COG0540	Belongs to the ATCase OTCase family
B9G99_RS07085	COG2066	Belongs to the glutaminase family
B9G99_RS07090	COG1028	Short-chain dehydrogenase reductase Sdr
B9G99_RS07095	COG0084	hydrolase, TatD family'
B9G99_RS07100	COG1028	Short-chain dehydrogenase reductase Sdr
B9G99_RS07105	COG1028	Short-chain dehydrogenase reductase Sdr
B9G99_RS07110	COG1472	Belongs to the glycosyl hydrolase 3 family
B9G99_RS07125	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
B9G99_RS07135	COG4145	pantothenate transmembrane transporter activity
B9G99_RS07140	COG0671	phosphoesterase, PA-phosphatase related
B9G99_RS07145	COG2084	Dehydrogenase
B9G99_RS07150	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B9G99_RS07155	COG1722	exodeoxyribonuclease VII activity
B9G99_RS07160	COG0142	geranyltranstransferase activity
B9G99_RS07165	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B9G99_RS07175	COG1607	acyl-coa hydrolase
B9G99_RS07180	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B9G99_RS07185	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B9G99_RS07195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B9G99_RS07200	COG4597	amino acid ABC transporter
B9G99_RS07205	COG0765	amino acid transport
B9G99_RS07210	COG1126	abc transporter atp-binding protein
B9G99_RS07215	COG0840	transmembrane signaling receptor activity
B9G99_RS07220	COG0840	transmembrane signaling receptor activity
B9G99_RS07230	COG0840	transmembrane signaling receptor activity
B9G99_RS07250	COG0004	ammonium transporteR
B9G99_RS07260	COG1297	OPT oligopeptide transporter protein
B9G99_RS07270	COG0277	FAD linked oxidase domain protein
B9G99_RS07275	COG0606	chelatase, subunit chli
B9G99_RS07300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B9G99_RS07310	COG0154	amidase activity
B9G99_RS07315	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B9G99_RS07325	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B9G99_RS07340	COG2363	Small membrane protein
B9G99_RS07345	COG1115	amino acid carrier protein
B9G99_RS07360	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B9G99_RS07380	COG0488	(ABC) transporter
B9G99_RS07385	COG4572	Cation transport regulator
B9G99_RS07395	COG1490	D-aminoacyl-tRNA deacylase activity
B9G99_RS07410	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B9G99_RS07415	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B9G99_RS07420	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B9G99_RS07420	COG0649	NAD binding
B9G99_RS07430	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
B9G99_RS07440	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B9G99_RS07450	COG0839	Belongs to the complex I subunit 6 family
B9G99_RS07455	COG0713	ATP synthesis coupled electron transport
B9G99_RS07460	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B9G99_RS07480	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B9G99_RS07485	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B9G99_RS07495	COG1011	Hydrolase
B9G99_RS07500	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B9G99_RS07510	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B9G99_RS07525	COG0165	Argininosuccinate lyase
B9G99_RS07540	COG2959	enzyme of heme biosynthesis
B9G99_RS07550	COG0612	Peptidase, M16
B9G99_RS07565	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
B9G99_RS07570	COG2132	Multicopper oxidase
B9G99_RS07580	COG3038	cytochrome b561
B9G99_RS07590	COG0123	including yeast histone deacetylase and acetoin utilization protein
B9G99_RS07595	COG0514	ATP-dependent DNA helicase (RecQ)
B9G99_RS07605	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B9G99_RS07620	COG2059	Chromate
B9G99_RS07625	COG2059	Chromate
B9G99_RS07645	COG0477	Major facilitator Superfamily
B9G99_RS07655	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B9G99_RS07660	COG1228	amidohydrolase
B9G99_RS07665	COG0583	DNA-binding transcription factor activity
B9G99_RS07675	COG1192	Involved in chromosome partitioning
B9G99_RS07690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B9G99_RS07710	COG2358	TRAP transporter, solute receptor (TAXI family
B9G99_RS07715	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B9G99_RS07750	COG2186	Transcriptional regulator
B9G99_RS07760	COG1953	Uracil, thiamine, allantoin
B9G99_RS07790	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B9G99_RS07805	COG1609	Transcriptional regulator
B9G99_RS07815	COG0113	porphobilinogen synthase activity
B9G99_RS07825	COG0113	porphobilinogen synthase activity
B9G99_RS07835	COG1944	ATP diphosphatase activity
B9G99_RS07860	COG2146	nitrite reductase [NAD(P)H] activity
B9G99_RS07860	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B9G99_RS07865	COG2146	nitrite reductase [NAD(P)H] activity
B9G99_RS07865	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B9G99_RS07870	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B9G99_RS07880	COG0243	molybdopterin cofactor binding
B9G99_RS07885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B9G99_RS07885	COG1648	precorrin-2 dehydrogenase activity
B9G99_RS07890	COG2223	nitrite transmembrane transporter activity
B9G99_RS07895	COG3707	response regulator
B9G99_RS07900	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
B9G99_RS07905	COG0402	S-adenosylhomocysteine deaminase activity
B9G99_RS07910	COG1028	Short-chain dehydrogenase reductase Sdr
B9G99_RS07915	COG1063	alcohol dehydrogenase
B9G99_RS07920	COG1172	Belongs to the binding-protein-dependent transport system permease family
B9G99_RS07925	COG1129	ABC transporter
B9G99_RS07930	COG1879	ABC-type sugar transport system periplasmic component
B9G99_RS07935	COG1069	ribulokinase activity
B9G99_RS07940	COG1126	abc transporter atp-binding protein
B9G99_RS07975	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B9G99_RS07980	COG2807	transmembrane transport
B9G99_RS07990	COG1121	(ABC) transporter
B9G99_RS07995	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B9G99_RS08005	COG0589	response to stress
B9G99_RS08010	COG5383	Protein conserved in bacteria
B9G99_RS08020	COG2149	membrane
B9G99_RS08030	COG1742	UPF0060 membrane protein
B9G99_RS08055	COG0840	transmembrane signaling receptor activity
B9G99_RS08060	COG3443	Belongs to the bacterial solute-binding protein 9 family
B9G99_RS08065	COG0583	DNA-binding transcription factor activity
B9G99_RS08070	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
B9G99_RS08075	COG1473	amidohydrolase
B9G99_RS08095	COG0446	pyridine nucleotide-disulphide oxidoreductase
B9G99_RS08095	COG1902	pentaerythritol trinitrate reductase activity
B9G99_RS08100	COG2181	nitrate reductase activity
B9G99_RS08100	COG0247	lactate metabolic process
B9G99_RS08105	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B9G99_RS08120	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B9G99_RS08135	COG1017	nitric oxide dioxygenase activity
B9G99_RS08135	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B9G99_RS08145	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B9G99_RS08180	COG0784	Response regulator, receiver
B9G99_RS08180	COG2205	protein histidine kinase activity
B9G99_RS08180	COG5002	protein histidine kinase activity
B9G99_RS08205	COG1230	cation diffusion facilitator family transporter
B9G99_RS08215	COG1196	nuclear chromosome segregation
B9G99_RS08215	COG0739	heme binding
B9G99_RS08215	COG0741	lytic transglycosylase activity
B9G99_RS08225	COG0789	Transcriptional regulator
B9G99_RS08240	COG0815	Transfers the fatty acyl group on membrane lipoproteins
B9G99_RS08270	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B9G99_RS08275	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B9G99_RS08290	COG0530	calcium, potassium:sodium antiporter activity
B9G99_RS08310	COG3083	sulfuric ester hydrolase activity
B9G99_RS08320	COG1230	cation diffusion facilitator family transporter
B9G99_RS08345	COG0673	inositol 2-dehydrogenase activity
B9G99_RS08360	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B9G99_RS08365	COG3395	kinase activity
B9G99_RS08370	COG2962	Rard protein
B9G99_RS08385	COG0431	NADPH-dependent FMN reductase
B9G99_RS08390	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B9G99_RS08400	COG0583	DNA-binding transcription factor activity
B9G99_RS08435	COG5006	permease, DMT superfamily
B9G99_RS08445	COG2354	Protein conserved in bacteria
B9G99_RS08455	COG2197	response regulator
B9G99_RS08515	COG0667	Aldo Keto reductase
B9G99_RS08520	COG0791	NLP P60 protein
B9G99_RS08525	COG5285	phytanoyl-CoA dioxygenase
B9G99_RS08530	COG0179	Fumarylacetoacetate (FAA) hydrolase
B9G99_RS08535	COG0129	dihydroxy-acid dehydratase activity
B9G99_RS08540	COG0006	proline dipeptidase activity
B9G99_RS08560	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B9G99_RS08585	COG4221	oxidoreductase activity
B9G99_RS08590	COG1757	Na H antiporter
B9G99_RS08595	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
B9G99_RS08605	COG1166	arginine decarboxylase activity
B9G99_RS08620	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B9G99_RS08630	COG0463	Glycosyl transferase, family 2
B9G99_RS08650	COG0840	transmembrane signaling receptor activity
B9G99_RS08665	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B9G99_RS08670	COG0583	DNA-binding transcription factor activity
B9G99_RS08675	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B9G99_RS08680	COG2301	Belongs to the HpcH HpaI aldolase family
B9G99_RS08695	COG1595	DNA-templated transcription, initiation
B9G99_RS08705	COG3486	L-lysine 6-monooxygenase (NADPH) activity
B9G99_RS08710	COG0076	glutamate decarboxylase activity
B9G99_RS08715	COG4774	siderophore transport
B9G99_RS08750	COG2610	gluconate transmembrane transporter activity
B9G99_RS08755	COG1028	Short-chain dehydrogenase reductase Sdr
B9G99_RS08760	COG1063	alcohol dehydrogenase
B9G99_RS08795	COG2080	2 iron, 2 sulfur cluster binding
B9G99_RS08800	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B9G99_RS08805	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B9G99_RS08810	COG2080	2 iron, 2 sulfur cluster binding
B9G99_RS08815	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B9G99_RS08835	COG0523	cobalamin synthesis protein
B9G99_RS08845	COG0583	DNA-binding transcription factor activity
B9G99_RS08860	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
B9G99_RS08900	COG1487	ribonuclease activity
B9G99_RS08910	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
B9G99_RS08920	COG0586	Pfam SNARE associated Golgi protein
B9G99_RS08925	COG1444	tRNA N-acetyltransferase activity
B9G99_RS08930	COG2195	Cleaves the N-terminal amino acid of tripeptides
B9G99_RS08940	COG2814	Major facilitator Superfamily
B9G99_RS08960	COG1289	transmembrane transporter activity
B9G99_RS08980	COG2094	Belongs to the DNA glycosylase MPG family
B9G99_RS09045	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B9G99_RS09050	COG3162	membrane
B9G99_RS09065	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B9G99_RS09070	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B9G99_RS09075	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
B9G99_RS09080	COG3386	PFAM SMP-30 Gluconolaconase
B9G99_RS09085	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B9G99_RS09090	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B9G99_RS09090	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B9G99_RS09110	COG1914	H( )-stimulated, divalent metal cation uptake system
B9G99_RS09120	COG3012	SEC-C Motif Domain Protein
B9G99_RS09145	COG0025	NhaP-type Na H and K H
B9G99_RS09150	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B9G99_RS09155	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B9G99_RS09160	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
B9G99_RS09165	COG0025	NhaP-type Na H and K H
B9G99_RS09170	COG0693	protein deglycase activity
B9G99_RS09175	COG0693	protein deglycase activity
B9G99_RS09180	COG0667	Aldo Keto reductase
B9G99_RS09185	COG1322	Protein conserved in bacteria
B9G99_RS09190	COG1929	Belongs to the glycerate kinase type-1 family
B9G99_RS09220	COG1028	Short-chain dehydrogenase reductase Sdr
B9G99_RS09230	COG1535	isochorismatase
B9G99_RS09230	COG3433	isochorismatase activity
B9G99_RS09235	COG1021	2,3-dihydroxybenzoate-AMP ligase
B9G99_RS09240	COG1169	isochorismate synthase
B9G99_RS09245	COG4264	IucA IucC family
B9G99_RS09280	COG0583	DNA-binding transcription factor activity
B9G99_RS09285	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B9G99_RS09300	COG0154	amidase activity
B9G99_RS09315	COG2351	hydroxyisourate hydrolase activity
B9G99_RS09325	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B9G99_RS09330	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B9G99_RS09335	COG1309	transcriptional regulator
B9G99_RS09345	COG2233	PERMEase
B9G99_RS09350	COG2771	luxR family
B9G99_RS09350	COG2200	EAL domain
B9G99_RS09360	COG0243	molybdopterin cofactor binding
B9G99_RS09365	COG2814	Major facilitator Superfamily
B9G99_RS09370	COG1566	PFAM secretion protein HlyD family protein
B9G99_RS09375	COG1538	Outer membrane efflux protein
B9G99_RS09380	COG3038	cytochrome b561
B9G99_RS09390	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B9G99_RS09395	COG1349	DNA-binding transcription factor activity
B9G99_RS09400	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
B9G99_RS09405	COG1691	(AIR) carboxylase
B9G99_RS09410	COG1606	tRNA processing
B9G99_RS09415	COG3875	lactate racemase activity
B9G99_RS09430	COG0534	Mate efflux family protein
B9G99_RS09435	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B9G99_RS09440	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B9G99_RS09465	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B9G99_RS09470	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B9G99_RS09490	COG1051	belongs to the nudix hydrolase family
B9G99_RS09495	COG3180	Ammonia monooxygenase
B9G99_RS09510	COG1054	Belongs to the UPF0176 family
B9G99_RS09520	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B9G99_RS09540	COG0142	geranyltranstransferase activity
B9G99_RS09545	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B9G99_RS09550	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B9G99_RS09555	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B9G99_RS09560	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B9G99_RS09565	COG0268	Binds directly to 16S ribosomal RNA
B9G99_RS09575	COG0196	riboflavin kinase activity
B9G99_RS09580	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B9G99_RS09585	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B9G99_RS09590	COG1047	Peptidyl-prolyl cis-trans
B9G99_RS09595	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B9G99_RS09625	COG5002	protein histidine kinase activity
B9G99_RS09625	COG5001	Diguanylate cyclase
B9G99_RS09625	COG3447	MASE1 domain protein
B9G99_RS09635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B9G99_RS09675	COG0028	Belongs to the TPP enzyme family
B9G99_RS09680	COG0440	acetolactate synthase activity
B9G99_RS09685	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B9G99_RS09695	COG1183	phosphatidylcholine synthase activity
B9G99_RS09735	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B9G99_RS09745	COG0745	RESPONSE REGULATOR receiver
B9G99_RS09750	COG2205	protein histidine kinase activity
B9G99_RS09755	COG0583	DNA-binding transcription factor activity
B9G99_RS09775	COG0346	lactoylglutathione lyase activity
B9G99_RS09780	COG0671	phosphoesterase, PA-phosphatase related
B9G99_RS09785	COG0671	phosphoesterase, PA-phosphatase related
B9G99_RS09790	COG0525	valine-tRNA ligase activity
B9G99_RS09795	COG0840	transmembrane signaling receptor activity
B9G99_RS09805	COG1028	Short-chain dehydrogenase reductase Sdr
B9G99_RS09810	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B9G99_RS09815	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B9G99_RS09820	COG0795	lipopolysaccharide-transporting ATPase activity
B9G99_RS09825	COG0795	lipopolysaccharide-transporting ATPase activity
B9G99_RS09850	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B9G99_RS09860	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B9G99_RS09870	COG3148	PFAM DTW domain containing protein
B9G99_RS09875	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
B9G99_RS09885	COG0569	domain protein
B9G99_RS09890	COG3360	Dodecin
B9G99_RS09895	COG1335	isochorismatase
B9G99_RS09905	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B9G99_RS09910	COG0242	peptide deformylase activity
B9G99_RS09920	COG0758	DNA mediated transformation
B9G99_RS09925	COG0009	L-threonylcarbamoyladenylate synthase
B9G99_RS09930	COG0408	coproporphyrinogen oxidase activity
B9G99_RS09935	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B9G99_RS09940	COG0501	Belongs to the peptidase M48B family
B9G99_RS09960	COG1160	GTP binding
B9G99_RS09975	COG0124	histidyl-tRNA synthetase
B9G99_RS09980	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B9G99_RS09985	COG1426	Protein conserved in bacteria
B9G99_RS09995	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B9G99_RS10000	COG0105	UTP biosynthetic process
B9G99_RS10005	COG0316	Belongs to the HesB IscA family
B9G99_RS10010	COG1104	cysteine desulfurase activity
B9G99_RS10040	COG1862	Preprotein translocase
B9G99_RS10045	COG0343	queuine tRNA-ribosyltransferase activity
B9G99_RS10050	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B9G99_RS10065	COG0589	response to stress
B9G99_RS10080	COG4948	Mandelate Racemase Muconate Lactonizing
B9G99_RS10090	COG0583	DNA-binding transcription factor activity
B9G99_RS10095	COG0668	transmembrane transport
B9G99_RS10105	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B9G99_RS10250	COG2274	protein secretion by the type I secretion system
B9G99_RS10255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B9G99_RS10260	COG1538	Outer membrane efflux protein
B9G99_RS10285	COG3138	arginine N-succinyltransferase
B9G99_RS10290	COG1012	belongs to the aldehyde dehydrogenase family
B9G99_RS10295	COG3724	N-succinylarginine dihydrolase activity
B9G99_RS10300	COG1063	alcohol dehydrogenase
B9G99_RS10310	COG0531	amino acid
B9G99_RS10315	COG0519	Catalyzes the synthesis of GMP from XMP
B9G99_RS10315	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B9G99_RS10325	COG0657	acetylesterase activity
B9G99_RS10330	COG1966	Carbon starvation protein
B9G99_RS10335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B9G99_RS10340	COG4160	amino acid transport
B9G99_RS10355	COG2988	succinylglutamate desuccinylase activity
B9G99_RS10365	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B9G99_RS10370	COG2076	Multidrug Resistance protein
B9G99_RS10375	COG2076	Multidrug Resistance protein
B9G99_RS10390	COG0840	transmembrane signaling receptor activity
B9G99_RS10395	COG0473	3-isopropylmalate dehydrogenase activity
B9G99_RS10400	COG0596	Alpha beta hydrolase
B9G99_RS10420	COG0398	Pfam SNARE associated Golgi protein
B9G99_RS10430	COG3384	dioxygenase
B9G99_RS10440	COG0583	DNA-binding transcription factor activity
B9G99_RS10445	COG3228	Belongs to the MtfA family
B9G99_RS10455	COG3153	acetyltransferase
B9G99_RS10455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B9G99_RS10460	COG2056	Na+-H+ antiporter family
B9G99_RS10470	COG1840	ABC-type Fe3 transport system, periplasmic component
B9G99_RS10475	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
B9G99_RS10485	COG0459	protein refolding
B9G99_RS10490	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B9G99_RS10495	COG3030	protein affecting phage T7 exclusion by the F plasmid
B9G99_RS10500	COG3568	Endonuclease Exonuclease Phosphatase
B9G99_RS10500	COG1555	photosystem II stabilization
B9G99_RS10505	COG0284	orotidine-5'-phosphate decarboxylase activity
B9G99_RS10510	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
B9G99_RS10520	COG0776	regulation of translation
B9G99_RS10540	COG4608	Belongs to the ABC transporter superfamily
B9G99_RS10545	COG0444	Belongs to the ABC transporter superfamily
B9G99_RS10550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B9G99_RS10555	COG0601	transmembrane transport
B9G99_RS10565	COG0747	negative chemotaxis
B9G99_RS10600	COG0322	excinuclease ABC activity
B9G99_RS10635	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B9G99_RS10640	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B9G99_RS10645	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B9G99_RS10650	COG0137	argininosuccinate synthase activity
B9G99_RS10670	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B9G99_RS10675	COG2878	Part of a membrane complex involved in electron transport
B9G99_RS10680	COG5001	Diguanylate cyclase
B9G99_RS10680	COG4251	negative regulation of phosphorylation
B9G99_RS10680	COG3706	GGDEF domain
B9G99_RS10680	COG2203	Gaf domain
B9G99_RS10690	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B9G99_RS10690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B9G99_RS10725	COG0489	protein tyrosine kinase activity
B9G99_RS10730	COG0717	Belongs to the dCTP deaminase family
B9G99_RS10735	COG0789	Transcriptional regulator
B9G99_RS10745	COG2271	Major facilitator Superfamily
B9G99_RS10760	COG3391	amine dehydrogenase activity
B9G99_RS10780	COG0725	ABC transporter, periplasmic molybdate-binding protein
B9G99_RS10785	COG4149	molybdate abc transporter
B9G99_RS10800	COG5001	Diguanylate cyclase
B9G99_RS10800	COG4251	negative regulation of phosphorylation
B9G99_RS10800	COG3706	GGDEF domain
B9G99_RS10800	COG2203	Gaf domain
B9G99_RS10820	COG1609	Transcriptional regulator
B9G99_RS10830	COG1105	Belongs to the carbohydrate kinase PfkB family
B9G99_RS10835	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B9G99_RS10835	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B9G99_RS10835	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
B9G99_RS10840	COG0733	neurotransmitter:sodium symporter activity
B9G99_RS10850	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B9G99_RS10860	COG3265	gluconokinase activity
B9G99_RS10870	COG2017	converts alpha-aldose to the beta-anomer
B9G99_RS10880	COG3386	PFAM SMP-30 Gluconolaconase
B9G99_RS10895	COG0598	Magnesium transport protein CorA
B9G99_RS10910	COG0006	proline dipeptidase activity
B9G99_RS10915	COG3608	succinylglutamate desuccinylase aspartoacylase
B9G99_RS10920	COG1522	sequence-specific DNA binding
B9G99_RS10925	COG0504	CTP synthase activity
B9G99_RS10930	COG2877	3-deoxy-8-phosphooctulonate synthase activity
B9G99_RS10935	COG0148	phosphopyruvate hydratase activity
B9G99_RS10940	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
B9G99_RS10945	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B9G99_RS10950	COG1546	Belongs to the CinA family
B9G99_RS10955	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B9G99_RS10960	COG2137	regulation of response to DNA damage stimulus
B9G99_RS10965	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B9G99_RS10970	COG0527	aspartate kinase activity
B9G99_RS10975	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B9G99_RS11000	COG1739	Uncharacterized protein family UPF0029
B9G99_RS11005	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B9G99_RS11010	COG1196	nuclear chromosome segregation
B9G99_RS11015	COG3115	cell septum assembly
B9G99_RS11020	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B9G99_RS11025	COG3089	Belongs to the UPF0270 family
B9G99_RS11035	COG3290	protein histidine kinase activity
B9G99_RS11040	COG4565	transcriptional regulatory protein
B9G99_RS11045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B9G99_RS11045	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
B9G99_RS11050	COG2350	Protein conserved in bacteria
B9G99_RS11055	COG2917	probably involved in intracellular septation
B9G99_RS11060	COG0613	PHP domain protein
B9G99_RS11065	COG0009	L-threonylcarbamoyladenylate synthase
B9G99_RS11070	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B9G99_RS11075	COG5001	Diguanylate cyclase
B9G99_RS11085	COG1392	Phosphate transport regulator
B9G99_RS11090	COG0306	phosphate transporter
B9G99_RS11095	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B9G99_RS11095	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B9G99_RS11100	COG2205	protein histidine kinase activity
B9G99_RS11110	COG2204	response regulator
B9G99_RS11115	COG1570	exodeoxyribonuclease VII activity
B9G99_RS11125	COG0519	Catalyzes the synthesis of GMP from XMP
B9G99_RS11125	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B9G99_RS11130	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B9G99_RS11140	COG0583	DNA-binding transcription factor activity
B9G99_RS11150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B9G99_RS11155	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
B9G99_RS11160	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
B9G99_RS11165	COG2814	Major facilitator Superfamily
B9G99_RS11185	COG0583	DNA-binding transcription factor activity
B9G99_RS11195	COG4221	oxidoreductase activity
B9G99_RS11225	COG0251	oxidation-reduction process
B9G99_RS11245	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B9G99_RS11250	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B9G99_RS11260	COG0583	DNA-binding transcription factor activity
B9G99_RS11280	COG2814	Major facilitator Superfamily
B9G99_RS11290	COG3706	GGDEF domain
B9G99_RS11290	COG2203	Gaf domain
B9G99_RS11290	COG5001	Diguanylate cyclase
B9G99_RS11290	COG4251	negative regulation of phosphorylation
B9G99_RS11295	COG1238	metal cluster binding
B9G99_RS11300	COG0477	Major facilitator Superfamily
B9G99_RS11305	COG0667	Aldo Keto reductase
B9G99_RS11310	COG0625	glutathione transferase activity
B9G99_RS11315	COG0583	DNA-binding transcription factor activity
B9G99_RS11330	COG1301	dicarboxylic acid transport
B9G99_RS11340	COG2226	methyltransferase
B9G99_RS11350	COG1845	cytochrome c oxidase, subunit III
B9G99_RS11355	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B9G99_RS11360	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B9G99_RS11375	COG0456	acetyltransferase
B9G99_RS11385	COG0217	transcriptional regulatory protein
B9G99_RS11390	COG0513	Belongs to the DEAD box helicase family
B9G99_RS11400	COG5001	Diguanylate cyclase
B9G99_RS11400	COG3300	MHYT domain
B9G99_RS11415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B9G99_RS11420	COG2814	Major facilitator Superfamily
B9G99_RS11425	COG2207	Transcriptional regulator
B9G99_RS11430	COG1064	alcohol dehydrogenase
B9G99_RS11440	COG3706	GGDEF domain
B9G99_RS11445	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
B9G99_RS11465	COG1061	Type III restriction enzyme res subunit
B9G99_RS11470	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B9G99_RS11475	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
B9G99_RS11480	COG0535	radical SAM domain protein
B9G99_RS11485	COG0535	radical SAM domain protein
B9G99_RS11495	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B9G99_RS11500	COG1187	pseudouridine synthase activity
B9G99_RS11520	COG4783	chaperone-mediated protein folding
B9G99_RS11525	COG0425	Belongs to the sulfur carrier protein TusA family
B9G99_RS11535	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B9G99_RS11540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B9G99_RS11550	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B9G99_RS11555	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B9G99_RS11570	COG3023	N-Acetylmuramoyl-L-alanine amidase
B9G99_RS11580	COG0508	dehydrogenase complex catalyzes the overall conversion of
B9G99_RS11585	COG0563	adenylate kinase activity
B9G99_RS11590	COG1214	PFAM Peptidase M22, glycoprotease
B9G99_RS11595	COG1968	undecaprenyl-diphosphatase activity
B9G99_RS11600	COG0742	ribosomal rna small subunit methyltransferase
B9G99_RS11605	COG2937	Belongs to the GPAT DAPAT family
B9G99_RS11610	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B9G99_RS11620	COG3091	SprT-like family
B9G99_RS11625	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B9G99_RS11635	COG2205	protein histidine kinase activity
B9G99_RS11635	COG2198	Histidine kinase
B9G99_RS11635	COG0784	Response regulator, receiver
B9G99_RS11640	COG0037	tRNA processing
B9G99_RS11675	COG2766	serine protein kinase
B9G99_RS11680	COG2718	Belongs to the UPF0229 family
B9G99_RS11685	COG2719	SpoVR family
B9G99_RS11710	COG0557	exoribonuclease II activity
B9G99_RS11720	COG0360	Binds together with S18 to 16S ribosomal RNA
B9G99_RS11725	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B9G99_RS11735	COG0359	binds to the 23S rRNA
B9G99_RS11740	COG0305	Participates in initiation and elongation during chromosome replication
B9G99_RS11750	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
B9G99_RS11750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B9G99_RS11765	COG3046	protein related to deoxyribodipyrimidine photolyase
B9G99_RS11770	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B9G99_RS11780	COG2212	antiporter activity
B9G99_RS11785	COG1863	multisubunit Na H antiporter MnhE subunit
B9G99_RS11790	COG0651	ATP synthesis coupled electron transport
B9G99_RS11795	COG1006	Multisubunit Na H antiporter MnhC subunit
B9G99_RS11800	COG2111	Na H antiporter
B9G99_RS11800	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B9G99_RS11805	COG2111	Na H antiporter
B9G99_RS11805	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B9G99_RS11810	COG2111	Na H antiporter
B9G99_RS11815	COG1006	Multisubunit Na H antiporter MnhC subunit
B9G99_RS11820	COG0651	ATP synthesis coupled electron transport
B9G99_RS11825	COG1863	multisubunit Na H antiporter MnhE subunit
B9G99_RS11830	COG2212	antiporter activity
B9G99_RS11835	COG1320	monovalent cation:proton antiporter activity
B9G99_RS11850	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
B9G99_RS11880	COG0318	PFAM AMP-dependent synthetase and ligase
B9G99_RS11885	COG1028	Short-chain dehydrogenase reductase Sdr
B9G99_RS11890	COG1960	acyl-CoA dehydrogenase activity
B9G99_RS11910	COG3954	Phosphoribulokinase
B9G99_RS11915	COG0537	adenosine 5'-monophosphoramidase activity
B9G99_RS11920	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
B9G99_RS11930	COG1765	OsmC-like protein
B9G99_RS11945	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
B9G99_RS11950	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B9G99_RS11955	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B9G99_RS11960	COG2967	ApaG domain
B9G99_RS11965	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B9G99_RS11970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B9G99_RS11975	COG0617	tRNA 3'-terminal CCA addition
B9G99_RS11990	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B9G99_RS11995	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B9G99_RS12000	COG0358	DNA primase activity
B9G99_RS12015	COG1760	l-serine dehydratase
B9G99_RS12045	COG2323	membrane
B9G99_RS12050	COG2818	Glycosylase
B9G99_RS12060	COG3706	GGDEF domain
B9G99_RS12060	COG2203	Gaf domain
B9G99_RS12060	COG5001	Diguanylate cyclase
B9G99_RS12060	COG4251	negative regulation of phosphorylation
B9G99_RS12070	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
B9G99_RS12075	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B9G99_RS12085	COG2814	Major facilitator Superfamily
B9G99_RS12085	COG0477	Major facilitator Superfamily
B9G99_RS12115	COG0656	L-ascorbic acid biosynthetic process
B9G99_RS12125	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B9G99_RS12250	COG3621	Patatin-like phospholipase
B9G99_RS12280	COG4983	Phage plasmid primase, P4 family domain protein
B9G99_RS12360	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B9G99_RS12365	COG4974	Belongs to the 'phage' integrase family
B9G99_RS12375	COG5383	Protein conserved in bacteria
B9G99_RS12380	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B9G99_RS12385	COG0583	DNA-binding transcription factor activity
B9G99_RS12390	COG1012	belongs to the aldehyde dehydrogenase family
B9G99_RS12395	COG1757	Na H antiporter
B9G99_RS12400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B9G99_RS12435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B9G99_RS12440	COG2186	Transcriptional regulator
B9G99_RS12445	COG2084	Dehydrogenase
B9G99_RS12450	COG3395	kinase activity
B9G99_RS12455	COG0235	Class ii aldolase
B9G99_RS12460	COG3622	Belongs to the hyi family
B9G99_RS12490	COG0739	heme binding
B9G99_RS12500	COG0435	Glutathione S-transferase
B9G99_RS12510	COG1515	deoxyribonuclease V activity
B9G99_RS12530	COG0420	3'-5' exonuclease activity
B9G99_RS12535	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
B9G99_RS12540	COG0588	phosphoglycerate mutase activity
B9G99_RS12545	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
B9G99_RS12550	COG1764	response to oxidative stress
B9G99_RS12565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B9G99_RS12575	COG1028	Short-chain dehydrogenase reductase Sdr
B9G99_RS12580	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
B9G99_RS12590	COG3608	succinylglutamate desuccinylase aspartoacylase
B9G99_RS12590	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
B9G99_RS12610	COG3214	Protein conserved in bacteria
B9G99_RS12630	COG0488	(ABC) transporter
B9G99_RS12645	COG3119	arylsulfatase activity
B9G99_RS12655	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B9G99_RS12660	COG0534	Mate efflux family protein
B9G99_RS12670	COG0840	transmembrane signaling receptor activity
B9G99_RS12705	COG1074	ATP-dependent DNA helicase activity
B9G99_RS12710	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B9G99_RS12740	COG0438	transferase activity, transferring glycosyl groups
B9G99_RS12770	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B9G99_RS12815	COG1346	cytolysis
B9G99_RS12835	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B9G99_RS12840	COG4988	ABC transporter
B9G99_RS12845	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B9G99_RS12870	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
B9G99_RS12875	COG1053	succinate dehydrogenase
B9G99_RS12880	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B9G99_RS12920	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B9G99_RS12920	COG0438	transferase activity, transferring glycosyl groups
B9G99_RS12930	COG0702	epimerase
B9G99_RS12935	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B9G99_RS12940	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B9G99_RS12945	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B9G99_RS12945	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
B9G99_RS12950	COG1263	PTS System
B9G99_RS12950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B9G99_RS12975	COG3106	COG3106 Predicted ATPase
B9G99_RS12985	COG0753	catalase activity
B9G99_RS13005	COG0791	NLP P60 protein
B9G99_RS13030	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B9G99_RS13050	COG1253	flavin adenine dinucleotide binding
B9G99_RS13075	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B9G99_RS13075	COG0678	peroxiredoxin activity
B9G99_RS13090	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B9G99_RS13095	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B9G99_RS13105	COG3139	Protein of unknown function (DUF1315)
B9G99_RS13115	COG0189	ligase activity
B9G99_RS13120	COG0456	acetyltransferase
B9G99_RS13125	COG2832	Protein of unknown function (DUF454)
B9G99_RS13130	COG1012	belongs to the aldehyde dehydrogenase family
B9G99_RS13140	COG0308	aminopeptidase N
B9G99_RS13155	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B9G99_RS13175	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
B9G99_RS13185	COG2116	formate transmembrane transporter activity
B9G99_RS13190	COG2814	Major facilitator Superfamily
B9G99_RS13195	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
B9G99_RS13205	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B9G99_RS13210	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B9G99_RS13215	COG1597	lipid kinase activity
B9G99_RS13225	COG1278	Cold shock
B9G99_RS13250	COG3932	Exopolysaccharide synthesis, ExoD
B9G99_RS13260	COG3339	Conserved Protein
B9G99_RS13265	COG0326	Molecular chaperone. Has ATPase activity
B9G99_RS13270	COG2992	FlgJ-related protein
B9G99_RS13275	COG0642	Histidine kinase
B9G99_RS13285	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B9G99_RS13300	COG0596	Alpha beta hydrolase
B9G99_RS13315	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B9G99_RS13325	COG3248	Nucleoside-binding outer membrane protein
B9G99_RS13335	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B9G99_RS13340	COG0066	3-isopropylmalate dehydratase activity
B9G99_RS13345	COG0473	3-isopropylmalate dehydrogenase activity
B9G99_RS13370	COG0135	phosphoribosylanthranilate isomerase activity
B9G99_RS13375	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B9G99_RS13380	COG0285	dihydrofolate synthase activity
B9G99_RS13405	COG0583	DNA-binding transcription factor activity
B9G99_RS13415	COG0534	Mate efflux family protein
B9G99_RS13430	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B9G99_RS13435	COG0011	TIGRFAM Protein of
B9G99_RS13445	COG0583	DNA-binding transcription factor activity
B9G99_RS13450	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B9G99_RS13455	COG0569	domain protein
B9G99_RS13475	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B9G99_RS13480	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B9G99_RS13490	COG0277	FAD linked oxidase domain protein
B9G99_RS13490	COG0247	lactate metabolic process
B9G99_RS13495	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B9G99_RS13580	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B9G99_RS13585	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B9G99_RS13590	COG0583	DNA-binding transcription factor activity
B9G99_RS13625	COG1040	competence protein
B9G99_RS13635	COG0302	gtp cyclohydrolase
B9G99_RS13645	COG0138	bifunctional purine biosynthesis protein purh
B9G99_RS13660	COG2264	protein methyltransferase activity
B9G99_RS13670	COG0511	ligase activity, forming carbon-carbon bonds
B9G99_RS13690	COG0205	6-phosphofructokinase activity
B9G99_RS13700	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B9G99_RS13705	COG0586	Pfam SNARE associated Golgi protein
B9G99_RS13710	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B9G99_RS13715	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B9G99_RS13725	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B9G99_RS13730	COG0768	penicillin binding
B9G99_RS13735	COG0772	Belongs to the SEDS family
B9G99_RS13740	COG2951	lytic endotransglycosylase activity
B9G99_RS13750	COG1686	Belongs to the peptidase S11 family
B9G99_RS13755	COG2921	Belongs to the UPF0250 family
B9G99_RS13760	COG0321	lipoyl(octanoyl) transferase activity
B9G99_RS13765	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B9G99_RS13775	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
B9G99_RS13780	COG0604	alcohol dehydrogenase
B9G99_RS13785	COG1051	belongs to the nudix hydrolase family
B9G99_RS13795	COG0469	pyruvate kinase activity
B9G99_RS13815	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B9G99_RS13825	COG1472	Belongs to the glycosyl hydrolase 3 family
B9G99_RS13830	COG0668	transmembrane transport
B9G99_RS13835	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
B9G99_RS13840	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B9G99_RS13850	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
B9G99_RS13855	COG1805	sodium ion transport
B9G99_RS13865	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
B9G99_RS13870	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
B9G99_RS13875	COG2871	sodium ion transport
B9G99_RS13885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B9G99_RS13900	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B9G99_RS13910	COG4591	ABC-type transport system involved in lipoprotein release permease component
B9G99_RS13915	COG1136	(ABC) transporter
B9G99_RS13930	COG2333	competence protein COMEC
B9G99_RS13930	COG0658	competence protein
B9G99_RS13935	COG1132	(ABC) transporter
B9G99_RS13940	COG1663	tetraacyldisaccharide 4'-kinase activity
B9G99_RS13945	COG2835	tetraacyldisaccharide 4'-kinase activity
B9G99_RS13950	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B9G99_RS13955	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B9G99_RS13965	COG1530	ribonuclease E activity
B9G99_RS13980	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B9G99_RS13980	COG0616	signal peptide processing
B9G99_RS13985	COG0424	maF-like protein
B9G99_RS13995	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B9G99_RS14000	COG0416	fatty acid biosynthetic process
B9G99_RS14015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B9G99_RS14020	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B9G99_RS14025	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B9G99_RS14030	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B9G99_RS14035	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B9G99_RS14050	COG0084	hydrolase, TatD family'
B9G99_RS14060	COG0210	DNA helicase
B9G99_RS14090	COG0811	peptide transport
B9G99_RS14095	COG0811	peptide transport
B9G99_RS14100	COG0848	biopolymer transport protein
B9G99_RS14125	COG0513	Belongs to the DEAD box helicase family
B9G99_RS14130	COG1199	ATP-dependent helicase activity
B9G99_RS14135	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B9G99_RS14155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B9G99_RS14160	COG0481	GTPase activity
B9G99_RS14165	COG0681	Belongs to the peptidase S26 family
B9G99_RS14170	COG0571	ribonuclease III activity
B9G99_RS14175	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B9G99_RS14195	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B9G99_RS14200	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B9G99_RS14205	COG3956	TIGRFAM MazG family protein
B9G99_RS14210	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
B9G99_RS14215	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B9G99_RS14220	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B9G99_RS14240	COG2814	Major facilitator Superfamily
B9G99_RS14255	COG0442	prolyl-tRNA aminoacylation
B9G99_RS14275	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B9G99_RS14280	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B9G99_RS14285	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B9G99_RS14290	COG0215	cysteine-tRNA ligase activity
B9G99_RS14295	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B9G99_RS14315	COG0544	peptidyl-prolyl cis-trans isomerase activity
B9G99_RS14320	COG0740	serine-type endopeptidase activity
B9G99_RS14325	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B9G99_RS14330	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B9G99_RS14340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B9G99_RS14345	COG2130	NADP-dependent
B9G99_RS14360	COG0602	queuosine metabolic process
B9G99_RS14365	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B9G99_RS14390	COG4303	Ethanolamine ammonia lyase large subunit
B9G99_RS14395	COG4302	ethanolamine ammonia-lyase activity
B9G99_RS14400	COG1492	cobalamin metabolic process
B9G99_RS14420	COG1797	cobyrinic acid a,c-diamide synthase activity
B9G99_RS14435	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B9G99_RS14455	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
B9G99_RS14465	COG0778	Nitroreductase
B9G99_RS14495	COG2267	carboxylic ester hydrolase activity
B9G99_RS14500	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B9G99_RS14510	COG4239	(ABC) transporter, permease
B9G99_RS14515	COG4174	ABC transporter (Permease)
B9G99_RS14520	COG4166	transmembrane transport
B9G99_RS14525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B9G99_RS14535	COG0328	RNA-DNA hybrid ribonuclease activity
B9G99_RS14555	COG0616	signal peptide processing
B9G99_RS14560	COG0640	Transcriptional regulator
B9G99_RS14565	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B9G99_RS14570	COG0596	Alpha beta hydrolase
B9G99_RS14580	COG1321	iron dependent repressor
B9G99_RS14585	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B9G99_RS14590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B9G99_RS14595	COG1116	anion transmembrane transporter activity
B9G99_RS14605	COG3263	regulation of cellular component size
B9G99_RS14625	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
B9G99_RS14640	COG2920	part of a sulfur-relay system
B9G99_RS14645	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
B9G99_RS14650	COG0303	'Molybdopterin
B9G99_RS14655	COG0521	Mo-molybdopterin cofactor biosynthetic process
B9G99_RS14665	COG1396	sequence-specific DNA binding
B9G99_RS14670	COG0259	pyridoxamine-phosphate oxidase activity
B9G99_RS14685	COG1295	ribonuclease BN
B9G99_RS14690	COG2840	Smr protein MutS2
B9G99_RS14700	COG0316	Belongs to the HesB IscA family
B9G99_RS14700	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B9G99_RS14715	COG2166	iron-sulfur cluster assembly
B9G99_RS14725	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B9G99_RS14730	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B9G99_RS14735	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B9G99_RS14740	COG0735	belongs to the Fur family
B9G99_RS14750	COG1917	Cupin 2, conserved barrel domain protein
B9G99_RS14755	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B9G99_RS14760	COG0456	acetyltransferase
B9G99_RS14770	COG0288	reversible hydration of carbon dioxide
B9G99_RS14775	COG0429	hydrolase of the alpha beta-hydrolase fold
B9G99_RS14785	COG2911	Protein conserved in bacteria
B9G99_RS14790	COG0729	surface antigen
B9G99_RS14800	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B9G99_RS14810	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B9G99_RS14830	COG2885	chlorophyll binding
B9G99_RS14835	COG0823	Involved in the tonB-independent uptake of proteins
B9G99_RS14855	COG0824	Thioesterase
B9G99_RS14860	COG2255	four-way junction helicase activity
B9G99_RS14865	COG0632	four-way junction helicase activity
B9G99_RS14870	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B9G99_RS14875	COG0217	transcriptional regulatory protein
B9G99_RS14880	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B9G99_RS14890	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B9G99_RS14895	COG0671	phosphoesterase, PA-phosphatase related
B9G99_RS14905	COG1877	trehalose-phosphatase activity
B9G99_RS14910	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
B9G99_RS14920	COG0583	DNA-binding transcription factor activity
B9G99_RS14925	COG1301	dicarboxylic acid transport
B9G99_RS14960	COG1970	mechanosensitive ion channel activity
B9G99_RS14965	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B9G99_RS14975	COG4191	Histidine kinase
B9G99_RS14980	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
B9G99_RS15010	COG1705	Flagellar rod assembly protein muramidase FlgJ
B9G99_RS15010	COG1388	LysM domain
B9G99_RS15015	COG0438	transferase activity, transferring glycosyl groups
B9G99_RS15020	COG0671	phosphoesterase, PA-phosphatase related
B9G99_RS15025	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
B9G99_RS15030	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B9G99_RS15040	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B9G99_RS15045	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B9G99_RS15050	COG1115	amino acid carrier protein
B9G99_RS15055	COG0509	glycine decarboxylation via glycine cleavage system
B9G99_RS15060	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B9G99_RS15060	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B9G99_RS15065	COG0583	DNA-binding transcription factor activity
B9G99_RS15075	COG1611	Belongs to the LOG family
B9G99_RS15090	COG0776	regulation of translation
B9G99_RS15095	COG0072	phenylalanine-tRNA ligase activity
B9G99_RS15100	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B9G99_RS15105	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B9G99_RS15110	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B9G99_RS15115	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B9G99_RS15120	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B9G99_RS15135	COG0438	transferase activity, transferring glycosyl groups
B9G99_RS15140	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B9G99_RS15145	COG0471	metal ion transport
B9G99_RS15150	COG0786	glutamate:sodium symporter activity
B9G99_RS15155	COG0840	transmembrane signaling receptor activity
B9G99_RS15160	COG0402	S-adenosylhomocysteine deaminase activity
B9G99_RS15165	COG2233	PERMEase
B9G99_RS15185	COG2207	Transcriptional regulator
B9G99_RS15190	COG1191	sigma factor activity
B9G99_RS15225	COG1334	flagellar protein FlaG
B9G99_RS15240	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B9G99_RS15270	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B9G99_RS15290	COG1987	bacterial-type flagellum assembly
B9G99_RS15315	COG1706	bacterial-type flagellum-dependent cell motility
B9G99_RS15335	COG1749	Flagellar hook protein flgE
B9G99_RS15340	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
B9G99_RS15345	COG1558	bacterial-type flagellum-dependent cell motility
B9G99_RS15350	COG1815	bacterial-type flagellum-dependent cell motility
B9G99_RS15380	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B9G99_RS15385	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
B9G99_RS15390	COG0745	RESPONSE REGULATOR receiver
B9G99_RS15395	COG2201	protein-glutamate methylesterase activity
B9G99_RS15400	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
B9G99_RS15405	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B9G99_RS15410	COG0840	transmembrane signaling receptor activity
B9G99_RS15415	COG0835	chemotaxis
B9G99_RS15425	COG1360	Flagellar Motor Protein
B9G99_RS15465	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
B9G99_RS15475	COG1216	Glycosyl transferase, family 2
B9G99_RS15480	COG0438	transferase activity, transferring glycosyl groups
B9G99_RS15500	COG1596	polysaccharide export
B9G99_RS15510	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B9G99_RS15515	COG0788	formyltetrahydrofolate deformylase activity
B9G99_RS15530	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B9G99_RS15540	COG0315	cyclic pyranopterin monophosphate synthase activity
B9G99_RS15545	COG0303	'Molybdopterin
B9G99_RS15550	COG1763	Mo-molybdopterin cofactor biosynthetic process
B9G99_RS15555	COG0746	molybdenum cofactor guanylyltransferase activity
B9G99_RS15560	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B9G99_RS15565	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B9G99_RS15570	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
B9G99_RS15575	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B9G99_RS15580	COG0307	riboflavin synthase, alpha
B9G99_RS15585	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B9G99_RS15590	COG2011	ABC-type metal ion transport system permease component
B9G99_RS15595	COG1464	Belongs to the NlpA lipoprotein family
B9G99_RS15600	COG1956	GAF domain-containing protein
B9G99_RS15620	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B9G99_RS15625	COG1349	DNA-binding transcription factor activity
B9G99_RS15645	COG0659	secondary active sulfate transmembrane transporter activity
B9G99_RS15650	COG0432	Pfam Uncharacterised protein family UPF0047
B9G99_RS15655	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B9G99_RS15660	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B9G99_RS15665	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
B9G99_RS15670	COG2084	Dehydrogenase
B9G99_RS15690	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
B9G99_RS15695	COG2272	Belongs to the type-B carboxylesterase lipase family
B9G99_RS15710	COG0583	DNA-binding transcription factor activity
B9G99_RS15715	COG0697	spore germination
B9G99_RS15720	COG1309	transcriptional regulator
B9G99_RS15740	COG1968	undecaprenyl-diphosphatase activity
B9G99_RS15750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B9G99_RS15770	COG0210	DNA helicase
B9G99_RS15830	COG0582	viral genome integration into host DNA
B9G99_RS15840	COG0745	RESPONSE REGULATOR receiver
B9G99_RS15845	COG2205	protein histidine kinase activity
B9G99_RS15855	COG1715	Restriction endonuclease
B9G99_RS15870	COG0318	PFAM AMP-dependent synthetase and ligase
B9G99_RS15885	COG2186	Transcriptional regulator
B9G99_RS15925	COG1609	Transcriptional regulator
B9G99_RS15955	COG4948	Mandelate Racemase Muconate Lactonizing
B9G99_RS15965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B9G99_RS15980	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B9G99_RS15990	COG1028	Short-chain dehydrogenase reductase Sdr
B9G99_RS15995	COG1045	serine acetyltransferase
B9G99_RS16000	COG1199	ATP-dependent helicase activity
B9G99_RS16000	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B9G99_RS16010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B9G99_RS16030	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B9G99_RS16035	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B9G99_RS16040	COG0667	Aldo Keto reductase
B9G99_RS16055	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B9G99_RS16060	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B9G99_RS16065	COG1605	Chorismate mutase
B9G99_RS16065	COG0077	Prephenate dehydratase
B9G99_RS16070	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B9G99_RS16080	COG2974	May be involved in recombination
B9G99_RS16090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B9G99_RS16110	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B9G99_RS16115	COG0237	dephospho-CoA kinase activity
B9G99_RS16120	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
B9G99_RS16125	COG0352	thiamine-phosphate diphosphorylase activity
B9G99_RS16130	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B9G99_RS16135	COG0653	protein targeting
B9G99_RS16150	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
B9G99_RS16170	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B9G99_RS16175	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B9G99_RS16180	COG0772	Belongs to the SEDS family
B9G99_RS16185	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B9G99_RS16190	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B9G99_RS16195	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B9G99_RS16200	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B9G99_RS16210	COG3116	cell division
B9G99_RS16215	COG0275	rRNA processing
B9G99_RS16235	COG0792	nuclease activity
B9G99_RS16240	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B9G99_RS16245	COG2823	Periplasmic or secreted lipoprotein
B9G99_RS16250	COG2969	positive regulation of protein catabolic process
B9G99_RS16255	COG0625	glutathione transferase activity
B9G99_RS16260	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B9G99_RS16265	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B9G99_RS16270	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B9G99_RS16280	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B9G99_RS16285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B9G99_RS16295	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B9G99_RS16300	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B9G99_RS16305	COG5007	Belongs to the BolA IbaG family
B9G99_RS16320	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B9G99_RS16325	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B9G99_RS16330	COG1127	ABC transporter
B9G99_RS16340	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
B9G99_RS16355	COG1137	ATPase activity
B9G99_RS16360	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
B9G99_RS16375	COG1660	Displays ATPase and GTPase activities
B9G99_RS16385	COG2239	Acts as a magnesium transporter
B9G99_RS16390	COG0312	modulator of DNA gyrase
B9G99_RS16395	COG3028	Belongs to the UPF0307 family
B9G99_RS16400	COG0312	modulator of DNA gyrase
B9G99_RS16405	COG3164	Protein of unknown function
B9G99_RS16410	COG1530	ribonuclease E activity
B9G99_RS16415	COG0424	maF-like protein
B9G99_RS16420	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
B9G99_RS16425	COG1792	Involved in formation and maintenance of cell shape
B9G99_RS16430	COG1077	Cell shape determining protein MreB Mrl
B9G99_RS16435	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B9G99_RS16440	COG0154	amidase activity
B9G99_RS16445	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B9G99_RS16455	COG0142	geranyltranstransferase activity
B9G99_RS16475	COG0174	glutamine synthetase
B9G99_RS16490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B9G99_RS16510	COG1177	transmembrane transport
B9G99_RS16515	COG1176	ABC-type spermidine putrescine transport system, permease component I
B9G99_RS16520	COG3842	ATPase activity
B9G99_RS16525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B9G99_RS16530	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B9G99_RS16540	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B9G99_RS16545	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B9G99_RS16555	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
B9G99_RS16560	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B9G99_RS16575	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B9G99_RS16580	COG0193	aminoacyl-tRNA hydrolase activity
B9G99_RS16585	COG0697	spore germination
B9G99_RS16590	COG0012	GTP binding
B9G99_RS16600	COG1362	aminopeptidase activity
B9G99_RS16605	COG0793	Belongs to the peptidase S41A family
B9G99_RS16640	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate