locus-tag	class	description
CVV65_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CVV65_RS00010	COG0592	DNA-directed DNA polymerase activity
CVV65_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CVV65_RS00030	COG0187	DNA topoisomerase II activity
CVV65_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CVV65_RS00055	COG0516	GMP reductase activity
CVV65_RS00055	COG0517	IMP dehydrogenase activity
CVV65_RS00060	COG1686	Belongs to the peptidase S11 family
CVV65_RS00065	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CVV65_RS00070	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CVV65_RS00090	COG0586	Pfam SNARE associated Golgi protein
CVV65_RS00095	COG0671	phosphoesterase, PA-phosphatase related
CVV65_RS00130	COG1309	transcriptional regulator
CVV65_RS00135	COG0656	L-ascorbic acid biosynthetic process
CVV65_RS00140	COG0789	Transcriptional regulator
CVV65_RS00145	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CVV65_RS00150	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CVV65_RS00155	COG1705	Flagellar rod assembly protein muramidase FlgJ
CVV65_RS00155	COG1388	LysM domain
CVV65_RS00190	COG3852	Histidine kinase
CVV65_RS00195	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CVV65_RS00200	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CVV65_RS00205	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CVV65_RS00215	COG0564	pseudouridine synthase activity
CVV65_RS00220	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CVV65_RS00235	COG1982	Orn Lys Arg decarboxylase major
CVV65_RS00240	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CVV65_RS00245	COG3870	Protein conserved in bacteria
CVV65_RS00255	COG0470	DNA polymerase III
CVV65_RS00260	COG1774	PSP1 C-terminal conserved region
CVV65_RS00265	COG4467	Involved in initiation control of chromosome replication
CVV65_RS00270	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CVV65_RS00275	COG2002	toxin-antitoxin pair type II binding
CVV65_RS00285	COG0084	hydrolase, TatD family'
CVV65_RS00290	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CVV65_RS00295	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CVV65_RS00320	COG0179	Fumarylacetoacetate (FAA) hydrolase
CVV65_RS00325	COG4466	Protein conserved in bacteria
CVV65_RS00340	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CVV65_RS00340	COG1181	Belongs to the D-alanine--D-alanine ligase family
CVV65_RS00345	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CVV65_RS00355	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CVV65_RS00360	COG0251	oxidation-reduction process
CVV65_RS00365	COG2088	sporulation resulting in formation of a cellular spore
CVV65_RS00370	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CVV65_RS00380	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CVV65_RS00385	COG0193	aminoacyl-tRNA hydrolase activity
CVV65_RS00395	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CVV65_RS00400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CVV65_RS00405	COG2002	toxin-antitoxin pair type II binding
CVV65_RS00410	COG2244	polysaccharide biosynthetic process
CVV65_RS00415	COG3956	TIGRFAM MazG family protein
CVV65_RS00425	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CVV65_RS00455	COG1098	S1 RNA binding domain
CVV65_RS00475	COG3595	metallopeptidase activity
CVV65_RS00490	COG2208	phosphoserine phosphatase activity
CVV65_RS00505	COG0037	tRNA processing
CVV65_RS00510	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CVV65_RS00515	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CVV65_RS00525	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CVV65_RS00535	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CVV65_RS00540	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CVV65_RS00545	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CVV65_RS00550	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CVV65_RS00555	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CVV65_RS00565	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CVV65_RS00575	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CVV65_RS00605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVV65_RS00610	COG0765	amino acid transport
CVV65_RS00615	COG1126	abc transporter atp-binding protein
CVV65_RS00630	COG3880	PFAM UvrB UvrC protein
CVV65_RS00635	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CVV65_RS00640	COG0542	response to heat
CVV65_RS00645	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CVV65_RS00650	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CVV65_RS00660	COG4956	integral membrane protein (PIN domain superfamily)
CVV65_RS00665	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CVV65_RS00670	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CVV65_RS00675	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CVV65_RS00680	COG1045	serine acetyltransferase
CVV65_RS00685	COG0215	cysteine-tRNA ligase activity
CVV65_RS00690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CVV65_RS00695	COG3688	RNA-binding protein containing a PIN domain
CVV65_RS00705	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CVV65_RS00710	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CVV65_RS00715	COG0250	Participates in transcription elongation, termination and antitermination
CVV65_RS00720	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CVV65_RS00725	COG0081	regulation of translation
CVV65_RS00730	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CVV65_RS00735	COG0222	ribosome binding
CVV65_RS00740	COG2813	Specifically methylates the guanine in position
CVV65_RS00745	COG0085	RNA polymerase activity
CVV65_RS00750	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CVV65_RS00755	COG1358	cellular component organization or biogenesis
CVV65_RS00760	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CVV65_RS00765	COG0049	tRNA binding
CVV65_RS00770	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CVV65_RS00775	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CVV65_RS00785	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CVV65_RS00795	COG0089	rRNA binding
CVV65_RS00800	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CVV65_RS00805	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CVV65_RS00810	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CVV65_RS00815	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CVV65_RS00820	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CVV65_RS00825	COG0255	Belongs to the universal ribosomal protein uL29 family
CVV65_RS00830	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CVV65_RS00835	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CVV65_RS00850	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CVV65_RS00855	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CVV65_RS00860	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CVV65_RS00865	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CVV65_RS00870	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CVV65_RS00880	COG0200	Binds to the 23S rRNA
CVV65_RS00885	COG0201	protein transport
CVV65_RS00890	COG0563	adenylate kinase activity
CVV65_RS00895	COG0024	Methionine aminopeptidase
CVV65_RS00905	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CVV65_RS00910	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CVV65_RS00915	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CVV65_RS00920	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CVV65_RS00925	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CVV65_RS00930	COG0202	RNA polymerase activity
CVV65_RS00935	COG0203	ribosomal protein L17
CVV65_RS00940	COG0101	tRNA pseudouridine synthase activity
CVV65_RS00945	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CVV65_RS00950	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CVV65_RS00970	COG0726	polysaccharide deacetylase
CVV65_RS00985	COG0175	sulfate reduction
CVV65_RS00990	COG0730	response to heat
CVV65_RS00995	COG2046	Belongs to the sulfate adenylyltransferase family
CVV65_RS01000	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CVV65_RS01015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CVV65_RS01025	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CVV65_RS01040	COG1396	sequence-specific DNA binding
CVV65_RS01045	COG0071	Belongs to the small heat shock protein (HSP20) family
CVV65_RS01050	COG0697	spore germination
CVV65_RS01065	COG1316	TRANSCRIPTIONal
CVV65_RS01075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CVV65_RS01080	COG0736	holo-[acyl-carrier-protein] synthase activity
CVV65_RS01085	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CVV65_RS01085	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CVV65_RS01090	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CVV65_RS01095	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CVV65_RS01100	COG0864	Transcriptional regulator
CVV65_RS01105	COG2337	Toxic component of a toxin-antitoxin (TA) module
CVV65_RS01110	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CVV65_RS01115	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CVV65_RS01145	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CVV65_RS01150	COG0802	atpase or kinase
CVV65_RS01155	COG1214	PFAM Peptidase M22, glycoprotease
CVV65_RS01160	COG0456	acetyltransferase
CVV65_RS01165	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CVV65_RS01170	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CVV65_RS01175	COG0805	protein transport
CVV65_RS01185	COG0459	protein refolding
CVV65_RS01190	COG2124	cytochrome p450
CVV65_RS01195	COG0697	spore germination
CVV65_RS01200	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CVV65_RS01205	COG0346	lactoylglutathione lyase activity
CVV65_RS01210	COG2050	protein possibly involved in aromatic compounds catabolism
CVV65_RS01215	COG1028	Short-chain dehydrogenase reductase Sdr
CVV65_RS01225	COG0174	glutamine synthetase
CVV65_RS01230	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CVV65_RS01235	COG3511	phospholipase C
CVV65_RS01240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CVV65_RS01245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CVV65_RS01255	COG0667	Aldo Keto reductase
CVV65_RS01265	COG0791	NLP P60 protein
CVV65_RS01265	COG3883	PFAM NLP P60 protein
CVV65_RS01270	COG0714	Associated with various cellular activities
CVV65_RS01280	COG1305	Transglutaminase-like
CVV65_RS01285	COG0519	Catalyzes the synthesis of GMP from XMP
CVV65_RS01285	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CVV65_RS01290	COG2252	PERMEase
CVV65_RS01315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CVV65_RS01320	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CVV65_RS01325	COG3258	Cytochrome c
CVV65_RS01340	COG0697	spore germination
CVV65_RS01360	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CVV65_RS01365	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CVV65_RS01370	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CVV65_RS01375	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CVV65_RS01380	COG0047	phosphoribosylformylglycinamidine synthase activity
CVV65_RS01385	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CVV65_RS01390	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CVV65_RS01395	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CVV65_RS01405	COG0138	bifunctional purine biosynthesis protein purh
CVV65_RS01410	COG0151	Belongs to the GarS family
CVV65_RS01415	COG1136	(ABC) transporter
CVV65_RS01460	COG0492	ferredoxin-NADP+ reductase activity
CVV65_RS01465	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CVV65_RS01485	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CVV65_RS01500	COG0531	amino acid
CVV65_RS01505	COG1012	belongs to the aldehyde dehydrogenase family
CVV65_RS01510	COG0506	proline dehydrogenase activity
CVV65_RS01515	COG3290	protein histidine kinase activity
CVV65_RS01515	COG3829	transcription factor binding
CVV65_RS01530	COG2132	Multicopper oxidase
CVV65_RS01535	COG2132	Multicopper oxidase
CVV65_RS01545	COG1063	alcohol dehydrogenase
CVV65_RS01560	COG1414	Transcriptional regulator
CVV65_RS01565	COG0028	Belongs to the TPP enzyme family
CVV65_RS01570	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CVV65_RS01575	COG1984	allophanate hydrolase subunit 2
CVV65_RS01580	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CVV65_RS01600	COG0675	Transposase, IS605 OrfB family
CVV65_RS01605	COG3344	reverse transcriptase
CVV65_RS01650	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CVV65_RS01685	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CVV65_RS01690	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CVV65_RS01695	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CVV65_RS01735	COG1091	dTDP-4-dehydrorhamnose reductase activity
CVV65_RS01740	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
CVV65_RS01745	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CVV65_RS01750	COG0463	Glycosyl transferase, family 2
CVV65_RS01785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CVV65_RS01790	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CVV65_RS01825	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
CVV65_RS01885	COG0675	Transposase, IS605 OrfB family
CVV65_RS01890	COG3344	reverse transcriptase
CVV65_RS01915	COG2070	2-Nitropropane dioxygenase
CVV65_RS01930	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
CVV65_RS01940	COG0446	pyridine nucleotide-disulphide oxidoreductase
CVV65_RS01945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CVV65_RS01950	COG3835	regulator
CVV65_RS01960	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CVV65_RS01985	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CVV65_RS01990	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CVV65_RS01990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CVV65_RS02000	COG2226	methyltransferase
CVV65_RS02005	COG1215	transferase activity, transferring glycosyl groups
CVV65_RS02020	COG1971	Probably functions as a manganese efflux pump
CVV65_RS02035	COG4717	serine-type aminopeptidase activity
CVV65_RS02045	COG2059	Chromate
CVV65_RS02050	COG2059	Chromate
CVV65_RS02055	COG0861	Integral membrane protein TerC family
CVV65_RS02060	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CVV65_RS02065	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CVV65_RS02070	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CVV65_RS02080	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CVV65_RS02090	COG0564	pseudouridine synthase activity
CVV65_RS02100	COG3906	Belongs to the UPF0473 family
CVV65_RS02105	COG4846	Membrane protein involved in cytochrome C biogenesis
CVV65_RS02115	COG1937	Protein conserved in bacteria
CVV65_RS02120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CVV65_RS02125	COG1116	anion transmembrane transporter activity
CVV65_RS02185	COG0582	viral genome integration into host DNA
CVV65_RS02195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CVV65_RS02205	COG0667	Aldo Keto reductase
CVV65_RS02215	COG3344	reverse transcriptase
CVV65_RS02260	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CVV65_RS02285	COG1595	DNA-templated transcription, initiation
CVV65_RS02295	COG5658	integral membrane protein
CVV65_RS02300	COG0640	Transcriptional regulator
CVV65_RS02310	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CVV65_RS02315	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CVV65_RS02320	COG0137	argininosuccinate synthase activity
CVV65_RS02330	COG3693	PFAM glycoside hydrolase, family 10
CVV65_RS02340	COG3344	reverse transcriptase
CVV65_RS02350	COG3344	reverse transcriptase
CVV65_RS02355	COG0318	PFAM AMP-dependent synthetase and ligase
CVV65_RS02370	COG0804	urea catabolic process
CVV65_RS02375	COG0830	nickel cation binding
CVV65_RS02380	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CVV65_RS02385	COG0829	nickel cation binding
CVV65_RS02395	COG2884	Cell division ATP-binding protein ftsE
CVV65_RS02400	COG2177	Part of the ABC transporter FtsEX involved in
CVV65_RS02405	COG3409	Peptidoglycan-binding domain 1 protein
CVV65_RS02405	COG0793	Belongs to the peptidase S41A family
CVV65_RS02415	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CVV65_RS02425	COG1234	tRNA 3'-trailer cleavage
CVV65_RS02435	COG0556	nucleotide-excision repair
CVV65_RS02440	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CVV65_RS02445	COG1950	PFAM Membrane protein of
CVV65_RS02455	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CVV65_RS02460	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CVV65_RS02465	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CVV65_RS02470	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CVV65_RS02475	COG0131	Imidazoleglycerol-phosphate dehydratase
CVV65_RS02480	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CVV65_RS02485	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CVV65_RS02495	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CVV65_RS02495	COG0140	phosphoribosyl-ATP diphosphatase activity
CVV65_RS02500	COG0673	inositol 2-dehydrogenase activity
CVV65_RS02505	COG0673	inositol 2-dehydrogenase activity
CVV65_RS02515	COG2271	Major facilitator Superfamily
CVV65_RS02525	COG0318	PFAM AMP-dependent synthetase and ligase
CVV65_RS02530	COG2226	methyltransferase
CVV65_RS02550	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CVV65_RS02555	COG0457	Tetratricopeptide repeat
CVV65_RS02560	COG1660	Displays ATPase and GTPase activities
CVV65_RS02565	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CVV65_RS02570	COG1481	regulation of sporulation
CVV65_RS02585	COG1074	ATP-dependent DNA helicase activity
CVV65_RS02590	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CVV65_RS02595	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CVV65_RS02610	COG0126	phosphoglycerate kinase activity
CVV65_RS02615	COG0149	triose-phosphate isomerase activity
CVV65_RS02620	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CVV65_RS02625	COG0148	phosphopyruvate hydratase activity
CVV65_RS02630	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CVV65_RS02635	COG1647	Serine aminopeptidase, S33
CVV65_RS02640	COG0557	exoribonuclease II activity
CVV65_RS02645	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CVV65_RS02655	COG0318	PFAM AMP-dependent synthetase and ligase
CVV65_RS02660	COG1024	Enoyl-CoA hydratase
CVV65_RS02675	COG3679	Belongs to the UPF0342 family
CVV65_RS02680	COG0861	Integral membrane protein TerC family
CVV65_RS02705	COG1649	PFAM Uncharacterised BCR, COG1649
CVV65_RS02705	COG0726	polysaccharide deacetylase
CVV65_RS02720	COG0840	transmembrane signaling receptor activity
CVV65_RS02760	COG0675	Transposase, IS605 OrfB family
CVV65_RS02785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CVV65_RS02790	COG1309	transcriptional regulator
CVV65_RS02800	COG1175	transmembrane transport
CVV65_RS02810	COG1653	transport
CVV65_RS02815	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CVV65_RS02835	COG3679	Belongs to the UPF0342 family
CVV65_RS02845	COG0675	Transposase, IS605 OrfB family
CVV65_RS02850	COG1131	(ABC) transporter
CVV65_RS02865	COG0626	cystathionine gamma-synthase activity
CVV65_RS02875	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CVV65_RS02880	COG0531	amino acid
CVV65_RS02895	COG1595	DNA-templated transcription, initiation
CVV65_RS02905	COG0842	Transport permease protein
CVV65_RS02905	COG1131	(ABC) transporter
CVV65_RS02905	COG1716	ATPase activity
CVV65_RS02925	COG5002	protein histidine kinase activity
CVV65_RS02940	COG0745	RESPONSE REGULATOR receiver
CVV65_RS02945	COG5002	protein histidine kinase activity
CVV65_RS02950	COG0788	formyltetrahydrofolate deformylase activity
CVV65_RS02955	COG0367	asparagine synthase
CVV65_RS02965	COG0133	tryptophan synthase activity
CVV65_RS02980	COG3290	protein histidine kinase activity
CVV65_RS02980	COG3829	transcription factor binding
CVV65_RS02990	COG0439	Biotin carboxylase
CVV65_RS02995	COG0511	ligase activity, forming carbon-carbon bonds
CVV65_RS03000	COG1024	Enoyl-CoA hydratase
CVV65_RS03005	COG0840	transmembrane signaling receptor activity
CVV65_RS03005	COG3290	protein histidine kinase activity
CVV65_RS03010	COG1253	flavin adenine dinucleotide binding
CVV65_RS03025	COG5002	protein histidine kinase activity
CVV65_RS03025	COG5001	Diguanylate cyclase
CVV65_RS03030	COG1404	Belongs to the peptidase S8 family
CVV65_RS03035	COG0693	protein deglycase activity
CVV65_RS03075	COG0318	PFAM AMP-dependent synthetase and ligase
CVV65_RS03085	COG0477	Major facilitator Superfamily
CVV65_RS03090	COG0019	diaminopimelate decarboxylase activity
CVV65_RS03105	COG1937	Protein conserved in bacteria
CVV65_RS03115	COG2226	methyltransferase
CVV65_RS03120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CVV65_RS03125	COG0785	Cytochrome C biogenesis protein
CVV65_RS03130	COG0596	Alpha beta hydrolase
CVV65_RS03145	COG0646	methionine synthase
CVV65_RS03145	COG1410	methionine synthase
CVV65_RS03150	COG0427	acetyl-CoA hydrolase
CVV65_RS03160	COG1612	heme a metabolic process
CVV65_RS03165	COG0109	protoheme IX farnesyltransferase activity
CVV65_RS03170	COG4193	domain, Protein
CVV65_RS03170	COG5263	repeat protein
CVV65_RS03180	COG0656	L-ascorbic acid biosynthetic process
CVV65_RS03190	COG3250	beta-galactosidase activity
CVV65_RS03195	COG1063	alcohol dehydrogenase
CVV65_RS03200	COG0667	Aldo Keto reductase
CVV65_RS03210	COG0438	transferase activity, transferring glycosyl groups
CVV65_RS03245	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CVV65_RS03250	COG2814	Major facilitator Superfamily
CVV65_RS03280	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CVV65_RS03285	COG1960	acyl-CoA dehydrogenase activity
CVV65_RS03350	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CVV65_RS03365	COG3829	transcription factor binding
CVV65_RS03375	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CVV65_RS03380	COG1984	allophanate hydrolase subunit 2
CVV65_RS03395	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CVV65_RS03400	COG1012	belongs to the aldehyde dehydrogenase family
CVV65_RS03410	COG2030	dehydratase
CVV65_RS03420	COG0318	PFAM AMP-dependent synthetase and ligase
CVV65_RS03430	COG1968	undecaprenyl-diphosphatase activity
CVV65_RS03440	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CVV65_RS03445	COG1725	Transcriptional regulator
CVV65_RS03450	COG1131	(ABC) transporter
CVV65_RS03465	COG2233	PERMEase
CVV65_RS03470	COG0584	glycerophosphoryl diester phosphodiesterase
CVV65_RS03475	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CVV65_RS03480	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CVV65_RS03500	COG1279	arginine transmembrane transporter activity
CVV65_RS03510	COG1271	oxidase subunit
CVV65_RS03515	COG1294	oxidase, subunit
CVV65_RS03525	COG1331	Highly conserved protein containing a thioredoxin domain
CVV65_RS03535	COG2357	RelA SpoT domain protein
CVV65_RS03560	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CVV65_RS03585	COG1797	cobyrinic acid a,c-diamide synthase activity
CVV65_RS03600	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CVV65_RS03605	COG1492	cobalamin metabolic process
CVV65_RS03610	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
CVV65_RS03615	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CVV65_RS03620	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CVV65_RS03630	COG1335	isochorismatase
CVV65_RS03635	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CVV65_RS03640	COG1122	ATPase activity
CVV65_RS03645	COG1268	BioY protein
CVV65_RS03655	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CVV65_RS03660	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CVV65_RS03665	COG1309	transcriptional regulator
CVV65_RS03670	COG2086	electron transfer activity
CVV65_RS03675	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CVV65_RS03680	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CVV65_RS03685	COG2814	Major facilitator Superfamily
CVV65_RS03690	COG2010	Cytochrome c
CVV65_RS03690	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CVV65_RS03705	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CVV65_RS03710	COG3336	cytochrome c oxidase
CVV65_RS03720	COG0667	Aldo Keto reductase
CVV65_RS03725	COG2766	serine protein kinase
CVV65_RS03730	COG2718	Belongs to the UPF0229 family
CVV65_RS03735	COG2719	SpoVR family
CVV65_RS03740	COG2151	metal-sulfur cluster biosynthetic enzyme
CVV65_RS03760	COG2153	protein acetylation
CVV65_RS03770	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CVV65_RS03780	COG2197	response regulator
CVV65_RS03790	COG2766	serine protein kinase
CVV65_RS03795	COG2718	Belongs to the UPF0229 family
CVV65_RS03800	COG2719	SpoVR family
CVV65_RS03805	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CVV65_RS03805	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CVV65_RS03810	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CVV65_RS03820	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CVV65_RS03825	COG0602	queuosine metabolic process
CVV65_RS03830	COG0720	synthase
CVV65_RS03835	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CVV65_RS03840	COG1393	Belongs to the ArsC family
CVV65_RS03865	COG0772	Belongs to the SEDS family
CVV65_RS03890	COG1982	Orn Lys Arg decarboxylase major
CVV65_RS03895	COG0697	spore germination
CVV65_RS03915	COG1078	dGTPase activity
CVV65_RS03920	COG1215	transferase activity, transferring glycosyl groups
CVV65_RS03925	COG3377	Domain of unknown function (DUF1805)
CVV65_RS03930	COG1363	Peptidase, m42
CVV65_RS03945	COG1013	pyruvate-flavodoxin oxidoreductase activity
CVV65_RS03950	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CVV65_RS03950	COG0674	pyruvate-flavodoxin oxidoreductase activity
CVV65_RS03955	COG1725	Transcriptional regulator
CVV65_RS03960	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CVV65_RS03965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVV65_RS03970	COG0352	thiamine-phosphate diphosphorylase activity
CVV65_RS03975	COG2445	Protein of unknown function DUF86
CVV65_RS03985	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CVV65_RS03995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CVV65_RS04000	COG2096	Adenosyltransferase
CVV65_RS04005	COG0647	UMP catabolic process
CVV65_RS04010	COG1846	Transcriptional regulator
CVV65_RS04015	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CVV65_RS04020	COG0114	fumarate hydratase activity
CVV65_RS04030	COG1012	belongs to the aldehyde dehydrogenase family
CVV65_RS04040	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CVV65_RS04045	COG1132	(ABC) transporter
CVV65_RS04050	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CVV65_RS04100	COG0310	cobalt ion transport
CVV65_RS04115	COG1122	ATPase activity
CVV65_RS04120	COG0778	Nitroreductase
CVV65_RS04125	COG0183	Belongs to the thiolase family
CVV65_RS04130	COG0318	PFAM AMP-dependent synthetase and ligase
CVV65_RS04140	COG1131	(ABC) transporter
CVV65_RS04160	COG5002	protein histidine kinase activity
CVV65_RS04175	COG1131	(ABC) transporter
CVV65_RS04185	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CVV65_RS04190	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
CVV65_RS04195	COG0671	phosphoesterase, PA-phosphatase related
CVV65_RS04215	COG2814	Major facilitator Superfamily
CVV65_RS04220	COG1294	oxidase, subunit
CVV65_RS04225	COG1271	oxidase subunit
CVV65_RS04240	COG1349	DNA-binding transcription factor activity
CVV65_RS04255	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CVV65_RS04270	COG2151	metal-sulfur cluster biosynthetic enzyme
CVV65_RS04275	COG0396	ATPase activity
CVV65_RS04280	COG0719	Fe-S assembly protein
CVV65_RS04285	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CVV65_RS04290	COG0822	iron-sulfur transferase activity
CVV65_RS04295	COG0719	Fe-S assembly protein
CVV65_RS04305	COG1959	2 iron, 2 sulfur cluster binding
CVV65_RS04315	COG1024	Enoyl-CoA hydratase
CVV65_RS04340	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CVV65_RS04345	COG0387	Pfam Sodium calcium exchanger
CVV65_RS04350	COG0741	lytic transglycosylase activity
CVV65_RS04355	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CVV65_RS04360	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CVV65_RS04365	COG1605	Chorismate mutase
CVV65_RS04365	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CVV65_RS04370	COG0123	including yeast histone deacetylase and acetoin utilization protein
CVV65_RS04375	COG0517	IMP dehydrogenase activity
CVV65_RS04380	COG0454	-acetyltransferase
CVV65_RS04385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CVV65_RS04420	COG1028	Short-chain dehydrogenase reductase Sdr
CVV65_RS04440	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CVV65_RS04440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CVV65_RS04445	COG4585	Histidine kinase
CVV65_RS04460	COG1301	dicarboxylic acid transport
CVV65_RS04465	COG2814	Major facilitator Superfamily
CVV65_RS04495	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CVV65_RS04500	COG0277	FAD linked oxidase domain protein
CVV65_RS04520	COG3118	belongs to the thioredoxin family
CVV65_RS04530	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CVV65_RS04540	COG2176	DNA-directed DNA polymerase activity
CVV65_RS04545	COG0004	ammonium transporteR
CVV65_RS04550	COG3384	dioxygenase
CVV65_RS04560	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CVV65_RS04560	COG0646	methionine synthase
CVV65_RS04565	COG0180	Tryptophanyl-tRNA synthetase
CVV65_RS04580	COG0322	excinuclease ABC activity
CVV65_RS04585	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CVV65_RS04590	COG3275	phosphorelay sensor kinase activity
CVV65_RS04595	COG3279	Response regulator of the LytR AlgR family
CVV65_RS04600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CVV65_RS04605	COG1584	GPR1 FUN34 yaaH family protein
CVV65_RS04615	COG1993	acr, cog1993
CVV65_RS04620	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CVV65_RS04625	COG2009	succinate dehydrogenase
CVV65_RS04630	COG1053	succinate dehydrogenase
CVV65_RS04635	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CVV65_RS04640	COG2197	response regulator
CVV65_RS04645	COG1846	Transcriptional regulator
CVV65_RS04655	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CVV65_RS04670	COG0544	peptidyl-prolyl cis-trans isomerase activity
CVV65_RS04675	COG0740	serine-type endopeptidase activity
CVV65_RS04685	COG1067	ATP-dependent peptidase activity
CVV65_RS04685	COG0470	DNA polymerase III
CVV65_RS04695	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CVV65_RS04700	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CVV65_RS04705	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CVV65_RS04710	COG1648	precorrin-2 dehydrogenase activity
CVV65_RS04710	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CVV65_RS04715	COG0181	hydroxymethylbilane synthase activity
CVV65_RS04725	COG0113	porphobilinogen synthase activity
CVV65_RS04730	COG1522	sequence-specific DNA binding
CVV65_RS04735	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CVV65_RS04760	COG0525	valine-tRNA ligase activity
CVV65_RS04765	COG0285	dihydrofolate synthase activity
CVV65_RS04770	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CVV65_RS04780	COG3583	domain protein
CVV65_RS04780	COG3584	3D domain protein
CVV65_RS04795	COG0424	maF-like protein
CVV65_RS04800	COG2003	Belongs to the UPF0758 family
CVV65_RS04805	COG1077	Cell shape determining protein MreB Mrl
CVV65_RS04820	COG0850	regulation of cytokinetic process
CVV65_RS04825	COG2894	cell division
CVV65_RS04830	COG0772	Belongs to the SEDS family
CVV65_RS04845	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CVV65_RS04855	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CVV65_RS04865	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CVV65_RS04870	COG1902	pentaerythritol trinitrate reductase activity
CVV65_RS04885	COG1482	cell wall glycoprotein biosynthetic process
CVV65_RS04890	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CVV65_RS04895	COG0297	glycogen (starch) synthase activity
CVV65_RS04905	COG0436	Aminotransferase
CVV65_RS04910	COG1522	sequence-specific DNA binding
CVV65_RS04925	COG4537	Required for transformation and DNA binding
CVV65_RS04950	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CVV65_RS04955	COG0367	asparagine synthase
CVV65_RS04965	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CVV65_RS04970	COG0083	homoserine kinase activity
CVV65_RS04975	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CVV65_RS04985	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CVV65_RS04990	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CVV65_RS04995	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CVV65_RS05020	COG0006	proline dipeptidase activity
CVV65_RS05025	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CVV65_RS05040	COG3854	ATPases associated with a variety of cellular activities
CVV65_RS05080	COG0511	ligase activity, forming carbon-carbon bonds
CVV65_RS05085	COG0439	Biotin carboxylase
CVV65_RS05090	COG1302	Protein conserved in bacteria
CVV65_RS05105	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CVV65_RS05110	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CVV65_RS05115	COG0492	ferredoxin-NADP+ reductase activity
CVV65_RS05120	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CVV65_RS05125	COG1570	exodeoxyribonuclease VII activity
CVV65_RS05130	COG1722	exodeoxyribonuclease VII activity
CVV65_RS05140	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CVV65_RS05145	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CVV65_RS05150	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CVV65_RS05155	COG1438	arginine binding
CVV65_RS05160	COG0497	DNA recombination
CVV65_RS05165	COG0750	zinc metalloprotease
CVV65_RS05170	COG0745	RESPONSE REGULATOR receiver
CVV65_RS05175	COG0535	radical SAM domain protein
CVV65_RS05190	COG0586	Pfam SNARE associated Golgi protein
CVV65_RS05200	COG0492	ferredoxin-NADP+ reductase activity
CVV65_RS05210	COG1028	Short-chain dehydrogenase reductase Sdr
CVV65_RS05225	COG1285	pathogenesis
CVV65_RS05240	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CVV65_RS05245	COG1610	YqeY-like protein
CVV65_RS05250	COG0095	Lipoate-protein ligase
CVV65_RS05260	COG4864	UPF0365 protein
CVV65_RS05280	COG1702	phosphate starvation-inducible protein PhoH
CVV65_RS05285	COG1480	7TM receptor with intracellular HD hydrolase
CVV65_RS05290	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CVV65_RS05300	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CVV65_RS05310	COG0752	glycyl-tRNA synthetase alpha subunit
CVV65_RS05315	COG0751	glycine-tRNA ligase activity
CVV65_RS05320	COG0517	IMP dehydrogenase activity
CVV65_RS05325	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CVV65_RS05330	COG0574	Belongs to the PEP-utilizing enzyme family
CVV65_RS05330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CVV65_RS05335	COG0358	DNA primase activity
CVV65_RS05340	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CVV65_RS05345	COG1960	acyl-CoA dehydrogenase activity
CVV65_RS05350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CVV65_RS05360	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CVV65_RS05400	COG1104	cysteine desulfurase activity
CVV65_RS05405	COG3344	reverse transcriptase
CVV65_RS05420	COG3328	transposase activity
CVV65_RS05500	COG1131	(ABC) transporter
CVV65_RS05545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CVV65_RS05565	COG4372	Transposase
CVV65_RS05640	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
CVV65_RS05645	COG1476	TRANSCRIPTIONal
CVV65_RS05675	COG3654	unkown
CVV65_RS05745	COG2271	Major facilitator Superfamily
CVV65_RS05755	COG1233	COG1233 Phytoene dehydrogenase and related
CVV65_RS05760	COG1012	belongs to the aldehyde dehydrogenase family
CVV65_RS05765	COG3437	response regulator, receiver
CVV65_RS05765	COG0784	Response regulator, receiver
CVV65_RS05775	COG0840	transmembrane signaling receptor activity
CVV65_RS05820	COG1725	Transcriptional regulator
CVV65_RS05825	COG1131	(ABC) transporter
CVV65_RS05835	COG1131	(ABC) transporter
CVV65_RS05855	COG0693	protein deglycase activity
CVV65_RS05875	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVV65_RS05895	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
CVV65_RS05900	COG4647	ligase activity
CVV65_RS05905	COG0145	ligase activity
CVV65_RS05915	COG1028	Short-chain dehydrogenase reductase Sdr
CVV65_RS05920	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CVV65_RS05925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CVV65_RS05970	COG4221	oxidoreductase activity
CVV65_RS05975	COG0667	Aldo Keto reductase
CVV65_RS06005	COG1595	DNA-templated transcription, initiation
CVV65_RS06010	COG2204	response regulator
CVV65_RS06015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CVV65_RS06020	COG1028	Short-chain dehydrogenase reductase Sdr
CVV65_RS06030	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CVV65_RS06035	COG0477	Major facilitator Superfamily
CVV65_RS06090	COG2226	methyltransferase
CVV65_RS06100	COG0784	Response regulator, receiver
CVV65_RS06100	COG3437	response regulator, receiver
CVV65_RS06115	COG2204	response regulator
CVV65_RS06120	COG0784	Response regulator, receiver
CVV65_RS06120	COG2205	protein histidine kinase activity
CVV65_RS06120	COG2198	Histidine kinase
CVV65_RS06145	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CVV65_RS06145	COG2755	lipolytic protein G-D-S-L family
CVV65_RS06160	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CVV65_RS06165	COG0604	alcohol dehydrogenase
CVV65_RS06175	COG3344	reverse transcriptase
CVV65_RS06180	COG3344	reverse transcriptase
CVV65_RS06190	COG3344	reverse transcriptase
CVV65_RS06210	COG4221	oxidoreductase activity
CVV65_RS06210	COG3321	synthase
CVV65_RS06210	COG0604	alcohol dehydrogenase
CVV65_RS06210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CVV65_RS06230	COG0347	Belongs to the P(II) protein family
CVV65_RS06235	COG0004	ammonium transporteR
CVV65_RS06240	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CVV65_RS06255	COG2508	Transcriptional regulator
CVV65_RS06260	COG1953	Uracil, thiamine, allantoin
CVV65_RS06265	COG0586	Pfam SNARE associated Golgi protein
CVV65_RS06275	COG1960	acyl-CoA dehydrogenase activity
CVV65_RS06280	COG5018	Exonuclease
CVV65_RS06290	COG2814	Major facilitator Superfamily
CVV65_RS06305	COG2186	Transcriptional regulator
CVV65_RS06315	COG0277	FAD linked oxidase domain protein
CVV65_RS06320	COG0247	lactate metabolic process
CVV65_RS06325	COG1606	tRNA processing
CVV65_RS06330	COG1691	(AIR) carboxylase
CVV65_RS06340	COG2721	sulfolactate sulfo-lyase activity
CVV65_RS06345	COG1349	DNA-binding transcription factor activity
CVV65_RS06355	COG3842	ATPase activity
CVV65_RS06365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CVV65_RS06370	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CVV65_RS06375	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CVV65_RS06380	COG0583	DNA-binding transcription factor activity
CVV65_RS06385	COG1380	Effector of murein hydrolase LrgA
CVV65_RS06390	COG1346	cytolysis
CVV65_RS06410	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CVV65_RS06415	COG0798	PFAM Bile acid sodium symporter
CVV65_RS06420	COG0640	Transcriptional regulator
CVV65_RS06430	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CVV65_RS06455	COG2363	Small membrane protein
CVV65_RS06465	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CVV65_RS06470	COG1183	phosphatidylcholine synthase activity
CVV65_RS06475	COG1028	Short-chain dehydrogenase reductase Sdr
CVV65_RS06495	COG1937	Protein conserved in bacteria
CVV65_RS06520	COG1464	Belongs to the NlpA lipoprotein family
CVV65_RS06525	COG2011	ABC-type metal ion transport system permease component
CVV65_RS06530	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CVV65_RS06535	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CVV65_RS06545	COG3344	reverse transcriptase
CVV65_RS06550	COG2197	response regulator
CVV65_RS06555	COG4585	Histidine kinase
CVV65_RS06565	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CVV65_RS06570	COG1278	Cold shock
CVV65_RS06580	COG4120	Belongs to the binding-protein-dependent transport system permease family
CVV65_RS06655	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CVV65_RS06670	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CVV65_RS06690	COG0409	Hydrogenase expression formation protein
CVV65_RS06710	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CVV65_RS06715	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CVV65_RS06745	COG0860	N-Acetylmuramoyl-L-alanine amidase
CVV65_RS06750	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CVV65_RS06755	COG0697	spore germination
CVV65_RS06770	COG3546	catalase activity
CVV65_RS06785	COG0745	RESPONSE REGULATOR receiver
CVV65_RS06790	COG2205	protein histidine kinase activity
CVV65_RS06800	COG2323	membrane
CVV65_RS06810	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CVV65_RS06820	COG1388	LysM domain
CVV65_RS06820	COG3584	3D domain protein
CVV65_RS06825	COG0735	belongs to the Fur family
CVV65_RS06865	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CVV65_RS06865	COG0512	Glutamine amidotransferase of anthranilate synthase
CVV65_RS06880	COG3442	glutamine amidotransferase
CVV65_RS06890	COG1376	ErfK ybiS ycfS ynhG family protein
CVV65_RS06900	COG1090	epimerase
CVV65_RS06925	COG3906	Belongs to the UPF0473 family
CVV65_RS06960	COG0740	serine-type endopeptidase activity
CVV65_RS06975	COG1104	cysteine desulfurase activity
CVV65_RS06980	COG0301	tRNA thio-modification
CVV65_RS06990	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CVV65_RS07020	COG1361	Conserved repeat domain
CVV65_RS07020	COG2911	Protein conserved in bacteria
CVV65_RS07020	COG3266	domain, Protein
CVV65_RS07025	COG1733	regulation of RNA biosynthetic process
CVV65_RS07040	COG1217	gtp-binding protein TYPA
CVV65_RS07055	COG0300	oxidoreductase activity
CVV65_RS07060	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CVV65_RS07065	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CVV65_RS07075	COG2001	Belongs to the MraZ family
CVV65_RS07080	COG0275	rRNA processing
CVV65_RS07090	COG0768	penicillin binding
CVV65_RS07095	COG0768	penicillin binding
CVV65_RS07100	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CVV65_RS07105	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CVV65_RS07110	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CVV65_RS07115	COG0772	Belongs to the SEDS family
CVV65_RS07125	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CVV65_RS07130	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CVV65_RS07135	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CVV65_RS07150	COG3856	small basic protein
CVV65_RS07155	COG0849	cell division
CVV65_RS07160	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CVV65_RS07170	COG1191	sigma factor activity
CVV65_RS07175	COG1191	sigma factor activity
CVV65_RS07190	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CVV65_RS07195	COG1799	cell septum assembly
CVV65_RS07205	COG2302	S4 RNA-binding domain
CVV65_RS07210	COG3599	regulation of cell shape
CVV65_RS07215	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CVV65_RS07225	COG1116	anion transmembrane transporter activity
CVV65_RS07230	COG1366	Belongs to the anti-sigma-factor antagonist family
CVV65_RS07235	COG2172	sigma factor antagonist activity
CVV65_RS07240	COG1191	sigma factor activity
CVV65_RS07260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CVV65_RS07270	COG0019	diaminopimelate decarboxylase activity
CVV65_RS07275	COG1686	Belongs to the peptidase S11 family
CVV65_RS07280	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CVV65_RS07280	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CVV65_RS07290	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CVV65_RS07290	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CVV65_RS07295	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CVV65_RS07300	COG1994	Peptidase M50
CVV65_RS07305	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CVV65_RS07310	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CVV65_RS07320	COG3874	Sporulation protein YtfJ
CVV65_RS07325	COG1686	Belongs to the peptidase S11 family
CVV65_RS07330	COG2715	membrane protein required for spore maturation
CVV65_RS07335	COG0700	Nucleoside recognition
CVV65_RS07340	COG1187	pseudouridine synthase activity
CVV65_RS07345	COG0745	RESPONSE REGULATOR receiver
CVV65_RS07350	COG5002	protein histidine kinase activity
CVV65_RS07365	COG1832	CoA-binding protein
CVV65_RS07370	COG0352	thiamine-phosphate diphosphorylase activity
CVV65_RS07380	COG2022	thiamine diphosphate biosynthetic process
CVV65_RS07385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CVV65_RS07395	COG1966	Carbon starvation protein
CVV65_RS07405	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CVV65_RS07410	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CVV65_RS07430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CVV65_RS07435	COG0067	glutamate synthase
CVV65_RS07435	COG0069	glutamate synthase activity
CVV65_RS07435	COG0070	glutamate synthase
CVV65_RS07440	COG1278	Cold shock
CVV65_RS07445	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CVV65_RS07450	COG0302	gtp cyclohydrolase
CVV65_RS07470	COG0210	DNA helicase
CVV65_RS07590	COG4862	establishment of competence for transformation
CVV65_RS07595	COG2707	UPF0756 membrane protein
CVV65_RS07600	COG1809	phosphosulfolactate synthase activity
CVV65_RS07605	COG2814	Major facilitator Superfamily
CVV65_RS07610	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CVV65_RS07625	COG2959	enzyme of heme biosynthesis
CVV65_RS07640	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CVV65_RS07650	COG0539	negative regulation of cytoplasmic translation
CVV65_RS07670	COG1160	GTP binding
CVV65_RS07675	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CVV65_RS07680	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CVV65_RS07685	COG0509	glycine decarboxylation via glycine cleavage system
CVV65_RS07690	COG0095	Lipoate-protein ligase
CVV65_RS07695	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CVV65_RS07700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CVV65_RS07720	COG2226	methyltransferase
CVV65_RS07725	COG0163	prenyltransferase activity
CVV65_RS07735	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CVV65_RS07740	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CVV65_RS07750	COG0105	UTP biosynthetic process
CVV65_RS07760	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CVV65_RS07775	COG1525	nuclease
CVV65_RS07805	COG2030	dehydratase
CVV65_RS07805	COG1012	belongs to the aldehyde dehydrogenase family
CVV65_RS07810	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CVV65_RS07815	COG0318	PFAM AMP-dependent synthetase and ligase
CVV65_RS07820	COG0318	PFAM AMP-dependent synthetase and ligase
CVV65_RS07825	COG1960	acyl-CoA dehydrogenase activity
CVV65_RS07830	COG1960	acyl-CoA dehydrogenase activity
CVV65_RS07835	COG0564	pseudouridine synthase activity
CVV65_RS07840	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CVV65_RS07845	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CVV65_RS07850	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CVV65_RS07855	COG0134	indole-3-glycerol-phosphate synthase activity
CVV65_RS07860	COG0135	phosphoribosylanthranilate isomerase activity
CVV65_RS07865	COG0133	tryptophan synthase activity
CVV65_RS07870	COG0159	tryptophan synthase activity
CVV65_RS07875	COG0287	Prephenate dehydrogenase
CVV65_RS07880	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CVV65_RS07930	COG0723	plastoquinol--plastocyanin reductase activity
CVV65_RS07945	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CVV65_RS07950	COG3949	Membrane
CVV65_RS07955	COG1968	undecaprenyl-diphosphatase activity
CVV65_RS07960	COG3314	Sporulation integral membrane protein YlbJ
CVV65_RS07965	COG1694	Mazg nucleotide pyrophosphohydrolase
CVV65_RS07980	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CVV65_RS07980	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CVV65_RS07985	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CVV65_RS07995	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CVV65_RS08005	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CVV65_RS08010	COG1793	dna ligase
CVV65_RS08015	COG1793	dna ligase
CVV65_RS08015	COG3285	dna ligase
CVV65_RS08025	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CVV65_RS08030	COG0402	S-adenosylhomocysteine deaminase activity
CVV65_RS08050	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CVV65_RS08055	COG3935	DnaD domain protein
CVV65_RS08065	COG1395	domain, Protein
CVV65_RS08095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CVV65_RS08100	COG1104	cysteine desulfurase activity
CVV65_RS08110	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
CVV65_RS08115	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CVV65_RS08120	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CVV65_RS08125	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CVV65_RS08130	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CVV65_RS08145	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CVV65_RS08180	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CVV65_RS08190	COG0174	glutamine synthetase
CVV65_RS08195	COG0789	Transcriptional regulator
CVV65_RS08200	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CVV65_RS08210	COG0464	growth
CVV65_RS08215	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CVV65_RS08220	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CVV65_RS08225	COG0179	Fumarylacetoacetate (FAA) hydrolase
CVV65_RS08230	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CVV65_RS08235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CVV65_RS08240	COG1129	ABC transporter
CVV65_RS08280	COG1923	regulation of RNA biosynthetic process
CVV65_RS08285	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CVV65_RS08290	COG2521	methyltransferase
CVV65_RS08290	COG2136	Putative SAM-dependent methyltransferase
CVV65_RS08295	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CVV65_RS08300	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CVV65_RS08310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CVV65_RS08330	COG0189	ligase activity
CVV65_RS08375	COG2359	stage V sporulation protein S
CVV65_RS08380	COG1692	metallophosphoesterase
CVV65_RS08385	COG1418	mRNA catabolic process
CVV65_RS08395	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CVV65_RS08400	COG0513	Belongs to the DEAD box helicase family
CVV65_RS08405	COG1058	Belongs to the CinA family
CVV65_RS08405	COG1546	Belongs to the CinA family
CVV65_RS08410	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CVV65_RS08415	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CVV65_RS08420	COG1666	GTP binding
CVV65_RS08445	COG1674	ftsk spoiiie
CVV65_RS08445	COG4980	gas vesicle protein
CVV65_RS08455	COG0740	serine-type endopeptidase activity
CVV65_RS08465	COG3829	transcription factor binding
CVV65_RS08465	COG3290	protein histidine kinase activity
CVV65_RS08475	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CVV65_RS08480	COG3243	poly(R)-hydroxyalkanoic acid synthase
CVV65_RS08485	COG1028	Short-chain dehydrogenase reductase Sdr
CVV65_RS08510	COG1028	Short-chain dehydrogenase reductase Sdr
CVV65_RS08555	COG1012	belongs to the aldehyde dehydrogenase family
CVV65_RS08565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CVV65_RS08570	COG1802	Transcriptional regulator
CVV65_RS08585	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CVV65_RS08590	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CVV65_RS08595	COG0527	aspartate kinase activity
CVV65_RS08600	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CVV65_RS08605	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CVV65_RS08610	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CVV65_RS08625	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
CVV65_RS08630	COG0756	dUTP diphosphatase activity
CVV65_RS08635	COG0612	Peptidase, M16
CVV65_RS08640	COG0726	polysaccharide deacetylase
CVV65_RS08650	COG1185	polyribonucleotide nucleotidyltransferase activity
CVV65_RS08655	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CVV65_RS08660	COG0196	riboflavin kinase activity
CVV65_RS08665	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CVV65_RS08675	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CVV65_RS08680	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CVV65_RS08680	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CVV65_RS08695	COG0195	Participates in both transcription termination and antitermination
CVV65_RS08700	COG0779	Required for maturation of 30S ribosomal subunits
CVV65_RS08705	COG2176	DNA-directed DNA polymerase activity
CVV65_RS08715	COG0442	prolyl-tRNA aminoacylation
CVV65_RS08720	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CVV65_RS08725	COG0750	zinc metalloprotease
CVV65_RS08735	COG4589	Belongs to the CDS family
CVV65_RS08740	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CVV65_RS08745	COG0233	cytoplasmic translational termination
CVV65_RS08750	COG0528	UMP kinase activity
CVV65_RS08755	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CVV65_RS08760	COG0052	Belongs to the universal ribosomal protein uS2 family
CVV65_RS08775	COG1191	sigma factor activity
CVV65_RS08785	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CVV65_RS08790	COG1776	CheC inhibitor of MCP methylation
CVV65_RS08795	COG0835	chemotaxis
CVV65_RS08800	COG0643	Histidine kinase
CVV65_RS08800	COG2198	Histidine kinase
CVV65_RS08805	COG2201	protein-glutamate methylesterase activity
CVV65_RS08810	COG0455	bacterial-type flagellum organization
CVV65_RS08815	COG1419	protein localization to endoplasmic reticulum
CVV65_RS08820	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CVV65_RS08825	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CVV65_RS08835	COG1987	bacterial-type flagellum assembly
CVV65_RS08840	COG1338	Plays a role in the flagellum-specific transport system
CVV65_RS08850	COG2201	protein-glutamate methylesterase activity
CVV65_RS08855	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CVV65_RS08855	COG1776	CheC inhibitor of MCP methylation
CVV65_RS08860	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CVV65_RS08865	COG1580	Controls the rotational direction of flagella during chemotaxis
CVV65_RS08870	COG1582	Flagellar protein (FlbD)
CVV65_RS08875	COG4786	Flagellar basal body rod
CVV65_RS08880	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CVV65_RS08900	COG1157	protein secretion by the type III secretion system
CVV65_RS08910	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CVV65_RS08915	COG1766	The M ring may be actively involved in energy transduction
CVV65_RS08920	COG1677	Flagellar hook-basal body complex protein FliE
CVV65_RS08925	COG1558	bacterial-type flagellum-dependent cell motility
CVV65_RS08930	COG1815	bacterial-type flagellum-dependent cell motility
CVV65_RS08935	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CVV65_RS08940	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CVV65_RS08945	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CVV65_RS08950	COG4974	Belongs to the 'phage' integrase family
CVV65_RS08955	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CVV65_RS08960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CVV65_RS08965	COG0758	DNA mediated transformation
CVV65_RS08970	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CVV65_RS08975	COG0045	succinate-CoA ligase (ADP-forming) activity
CVV65_RS08980	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CVV65_RS08990	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CVV65_RS08995	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CVV65_RS09010	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CVV65_RS09020	COG1104	cysteine desulfurase activity
CVV65_RS09025	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CVV65_RS09030	COG1827	regulation of RNA biosynthetic process
CVV65_RS09065	COG0644	oxidoreductase
CVV65_RS09070	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CVV65_RS09080	COG2132	Multicopper oxidase
CVV65_RS09090	COG0655	NAD(P)H dehydrogenase (quinone) activity
CVV65_RS09100	COG0792	nuclease activity
CVV65_RS09105	COG0768	penicillin binding
CVV65_RS09110	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CVV65_RS09115	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CVV65_RS09120	COG0681	Belongs to the peptidase S26 family
CVV65_RS09125	COG0335	large ribosomal subunit rRNA binding
CVV65_RS09130	COG0336	Belongs to the RNA methyltransferase TrmD family
CVV65_RS09135	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CVV65_RS09140	COG0228	four-way junction DNA binding
CVV65_RS09145	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CVV65_RS09150	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CVV65_RS09155	COG0552	protein localization to endoplasmic reticulum
CVV65_RS09160	COG1196	nuclear chromosome segregation
CVV65_RS09170	COG0571	ribonuclease III activity
CVV65_RS09175	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CVV65_RS09180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CVV65_RS09185	COG1028	Short-chain dehydrogenase reductase Sdr
CVV65_RS09190	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CVV65_RS09195	COG0416	fatty acid biosynthetic process
CVV65_RS09200	COG1349	DNA-binding transcription factor activity
CVV65_RS09200	COG2050	protein possibly involved in aromatic compounds catabolism
CVV65_RS09205	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CVV65_RS09215	COG3480	Lon protease (S16) C-terminal proteolytic domain
CVV65_RS09220	COG1752	Esterase of the alpha-beta hydrolase superfamily
CVV65_RS09225	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CVV65_RS09230	COG0742	ribosomal rna small subunit methyltransferase
CVV65_RS09235	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CVV65_RS09240	COG1461	Dihydroxyacetone kinase
CVV65_RS09245	COG1302	Protein conserved in bacteria
CVV65_RS09250	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CVV65_RS09260	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CVV65_RS09270	COG0515	serine threonine protein kinase
CVV65_RS09270	COG2815	serine threonine protein kinase
CVV65_RS09275	COG0631	protein serine/threonine phosphatase activity
CVV65_RS09280	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CVV65_RS09285	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CVV65_RS09285	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CVV65_RS09290	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CVV65_RS09295	COG0242	peptide deformylase activity
CVV65_RS09300	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CVV65_RS09305	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CVV65_RS09310	COG1758	RNA polymerase activity
CVV65_RS09315	COG0194	GDP metabolic process
CVV65_RS09320	COG2052	Domain of unknown function (DUF370)
CVV65_RS09325	COG1561	YicC-like family, N-terminal region
CVV65_RS09335	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CVV65_RS09345	COG4555	ABC transporter
CVV65_RS09370	COG0295	cytidine deaminase activity
CVV65_RS09380	COG0697	spore germination
CVV65_RS09385	COG1342	Belongs to the UPF0251 family
CVV65_RS09395	COG1940	carbohydrate kinase activity
CVV65_RS09405	COG0288	reversible hydration of carbon dioxide
CVV65_RS09410	COG0567	Dehydrogenase, E1 component
CVV65_RS09415	COG0508	dehydrogenase complex catalyzes the overall conversion of
CVV65_RS09420	COG4214	carbohydrate transport
CVV65_RS09430	COG4213	ABC transporter substrate-binding protein
CVV65_RS09450	COG0531	amino acid
CVV65_RS09460	COG2267	carboxylic ester hydrolase activity
CVV65_RS09515	COG0145	ligase activity
CVV65_RS09535	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CVV65_RS09540	COG2814	Major facilitator Superfamily
CVV65_RS09545	COG2508	Transcriptional regulator
CVV65_RS09550	COG0167	dihydroorotate dehydrogenase activity
CVV65_RS09555	COG0543	2 iron, 2 sulfur cluster binding
CVV65_RS09560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CVV65_RS09565	COG0284	orotidine-5'-phosphate decarboxylase activity
CVV65_RS09570	COG0167	dihydroorotate dehydrogenase activity
CVV65_RS09575	COG0543	2 iron, 2 sulfur cluster binding
CVV65_RS09585	COG0505	Belongs to the CarA family
CVV65_RS09600	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CVV65_RS09605	COG0564	pseudouridine synthase activity
CVV65_RS09610	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CVV65_RS09620	COG2814	Major facilitator Superfamily
CVV65_RS09635	COG1686	Belongs to the peptidase S11 family
CVV65_RS09640	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CVV65_RS09645	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CVV65_RS09650	COG4974	Belongs to the 'phage' integrase family
CVV65_RS09660	COG0686	Belongs to the AlaDH PNT family
CVV65_RS09665	COG0735	belongs to the Fur family
CVV65_RS09675	COG1300	Membrane
CVV65_RS09680	COG1379	DNA repair
CVV65_RS09695	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CVV65_RS09700	COG0346	lactoylglutathione lyase activity
CVV65_RS09715	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CVV65_RS09720	COG0508	dehydrogenase complex catalyzes the overall conversion of
CVV65_RS09725	COG0022	dehydrogenase e1 component
CVV65_RS09730	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CVV65_RS09740	COG3829	transcription factor binding
CVV65_RS09740	COG3290	protein histidine kinase activity
CVV65_RS09750	COG0521	Mo-molybdopterin cofactor biosynthetic process
CVV65_RS09755	COG0315	cyclic pyranopterin monophosphate synthase activity
CVV65_RS09760	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CVV65_RS09770	COG2814	Major facilitator Superfamily
CVV65_RS09780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CVV65_RS09785	COG0450	alkyl hydroperoxide reductase
CVV65_RS09790	COG3253	May function as heme-dependent peroxidase
CVV65_RS09820	COG0473	3-isopropylmalate dehydrogenase activity
CVV65_RS09825	COG2301	Belongs to the HpcH HpaI aldolase family
CVV65_RS09830	COG1802	Transcriptional regulator
CVV65_RS09840	COG2258	MOSC domain
CVV65_RS09850	COG0675	Transposase, IS605 OrfB family
CVV65_RS09855	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CVV65_RS09860	COG1283	sodium-dependent phosphate transmembrane transporter activity
CVV65_RS09870	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CVV65_RS09875	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CVV65_RS09880	COG1414	Transcriptional regulator
CVV65_RS09885	COG1960	acyl-CoA dehydrogenase activity
CVV65_RS09890	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVV65_RS09895	COG0183	Belongs to the thiolase family
CVV65_RS09905	COG1012	belongs to the aldehyde dehydrogenase family
CVV65_RS09915	COG1024	Enoyl-CoA hydratase
CVV65_RS09925	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CVV65_RS09930	COG1309	transcriptional regulator
CVV65_RS09935	COG2151	metal-sulfur cluster biosynthetic enzyme
CVV65_RS09950	COG3396	Phenylacetate-CoA oxygenase
CVV65_RS09960	COG2264	protein methyltransferase activity
CVV65_RS09965	COG0484	heat shock protein binding
CVV65_RS09980	COG1420	regulation of RNA biosynthetic process
CVV65_RS09985	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CVV65_RS09990	COG0481	GTPase activity
CVV65_RS10000	COG0860	N-Acetylmuramoyl-L-alanine amidase
CVV65_RS10010	COG0268	Binds directly to 16S ribosomal RNA
CVV65_RS10020	COG1466	dna polymerase III delta subunit
CVV65_RS10025	COG1252	NADH dehydrogenase
CVV65_RS10035	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CVV65_RS10045	COG1555	photosystem II stabilization
CVV65_RS10045	COG1596	polysaccharide export
CVV65_RS10050	COG1321	iron dependent repressor
CVV65_RS10055	COG0495	leucyl-tRNA aminoacylation
CVV65_RS10060	COG0799	negative regulation of ribosome biogenesis
CVV65_RS10065	COG1713	HD superfamily hydrolase involved in NAD metabolism
CVV65_RS10070	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CVV65_RS10075	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CVV65_RS10085	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CVV65_RS10090	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CVV65_RS10095	COG0768	penicillin binding
CVV65_RS10100	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CVV65_RS10105	COG4187	Peptidase family M20/M25/M40
CVV65_RS10110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CVV65_RS10125	COG1172	Belongs to the binding-protein-dependent transport system permease family
CVV65_RS10140	COG1802	Transcriptional regulator
CVV65_RS10145	COG1216	Glycosyl transferase, family 2
CVV65_RS10165	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CVV65_RS10170	COG1088	dTDP-glucose 4,6-dehydratase activity
CVV65_RS10175	COG1216	Glycosyl transferase, family 2
CVV65_RS10180	COG0438	transferase activity, transferring glycosyl groups
CVV65_RS10200	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CVV65_RS10200	COG0069	glutamate synthase activity
CVV65_RS10220	COG0463	Glycosyl transferase, family 2
CVV65_RS10220	COG0457	Tetratricopeptide repeat
CVV65_RS10225	COG0463	Glycosyl transferase, family 2
CVV65_RS10230	COG0457	Tetratricopeptide repeat
CVV65_RS10230	COG0463	Glycosyl transferase, family 2
CVV65_RS10235	COG0297	glycogen (starch) synthase activity
CVV65_RS10265	COG2045	Belongs to the ComB family
CVV65_RS10270	COG0318	PFAM AMP-dependent synthetase and ligase
CVV65_RS10285	COG0508	dehydrogenase complex catalyzes the overall conversion of
CVV65_RS10290	COG0022	dehydrogenase e1 component
CVV65_RS10295	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CVV65_RS10300	COG3284	Transcriptional regulator
CVV65_RS10350	COG4569	acetaldehyde dehydrogenase (acetylating) activity
CVV65_RS10405	COG0572	uridine kinase
CVV65_RS10410	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CVV65_RS10415	COG1752	Esterase of the alpha-beta hydrolase superfamily
CVV65_RS10440	COG1845	cytochrome c oxidase, subunit III
CVV65_RS10470	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CVV65_RS10485	COG0318	PFAM AMP-dependent synthetase and ligase
CVV65_RS10490	COG1960	acyl-CoA dehydrogenase activity
CVV65_RS10505	COG3942	CHAP domain
CVV65_RS10505	COG1388	LysM domain
CVV65_RS10510	COG0697	spore germination
CVV65_RS10520	COG4647	ligase activity
CVV65_RS10525	COG0145	ligase activity
CVV65_RS10540	COG0145	ligase activity
CVV65_RS10545	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
CVV65_RS10555	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CVV65_RS10560	COG4647	ligase activity
CVV65_RS10565	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
CVV65_RS10570	COG0145	ligase activity
CVV65_RS10575	COG3284	Transcriptional regulator
CVV65_RS10590	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CVV65_RS10595	COG2871	sodium ion transport
CVV65_RS10655	COG3906	Belongs to the UPF0473 family
CVV65_RS10660	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CVV65_RS10665	COG4472	Bacterial protein of unknown function (DUF965)
CVV65_RS10670	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CVV65_RS10675	COG0628	permease
CVV65_RS10680	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CVV65_RS10690	COG0746	molybdenum cofactor guanylyltransferase activity
CVV65_RS10695	COG0303	'Molybdopterin
CVV65_RS10705	COG3383	formate dehydrogenase (NAD+) activity
CVV65_RS10710	COG5609	conserved protein (DUF2294)
CVV65_RS10715	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CVV65_RS10730	COG0482	sulfurtransferase activity
CVV65_RS10735	COG1104	cysteine desulfurase activity
CVV65_RS10740	COG1959	2 iron, 2 sulfur cluster binding
CVV65_RS10755	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CVV65_RS10760	COG0124	histidyl-tRNA synthetase
CVV65_RS10770	COG1470	cell adhesion involved in biofilm formation
CVV65_RS10780	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CVV65_RS10785	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CVV65_RS10795	COG0612	Peptidase, M16
CVV65_RS10800	COG0612	Peptidase, M16
CVV65_RS10805	COG1252	NADH dehydrogenase
CVV65_RS10820	COG3842	ATPase activity
CVV65_RS10840	COG3344	reverse transcriptase
CVV65_RS10850	COG1960	acyl-CoA dehydrogenase activity
CVV65_RS10855	COG0183	Belongs to the thiolase family
CVV65_RS10860	COG1024	Enoyl-CoA hydratase
CVV65_RS10860	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVV65_RS10865	COG0318	PFAM AMP-dependent synthetase and ligase
CVV65_RS10870	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CVV65_RS10875	COG1703	isobutyryl-CoA mutase activity
CVV65_RS10875	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CVV65_RS10875	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CVV65_RS10880	COG3226	Transcriptional regulator
CVV65_RS10885	COG1028	Short-chain dehydrogenase reductase Sdr
CVV65_RS10895	COG0494	nUDIX hydrolase
CVV65_RS10905	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CVV65_RS10920	COG1181	Belongs to the D-alanine--D-alanine ligase family
CVV65_RS10925	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CVV65_RS10960	COG1361	Conserved repeat domain
CVV65_RS10965	COG1012	belongs to the aldehyde dehydrogenase family
CVV65_RS10970	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CVV65_RS10975	COG1063	alcohol dehydrogenase
CVV65_RS10985	COG2197	response regulator
CVV65_RS10990	COG0688	phosphatidylethanolamine metabolic process
CVV65_RS11000	COG1573	uracil-dna glycosylase
CVV65_RS11015	COG3584	3D domain protein
CVV65_RS11015	COG1388	LysM domain
CVV65_RS11035	COG0129	dihydroxy-acid dehydratase activity
CVV65_RS11045	COG4221	oxidoreductase activity
CVV65_RS11055	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CVV65_RS11075	COG1078	dGTPase activity
CVV65_RS11090	COG0587	DNA-directed DNA polymerase activity
CVV65_RS11100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CVV65_RS11110	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CVV65_RS11115	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CVV65_RS11120	COG2224	Isocitrate lyase
CVV65_RS11125	COG0583	DNA-binding transcription factor activity
CVV65_RS11135	COG2855	membrane
CVV65_RS11145	COG0412	Dienelactone hydrolase
CVV65_RS11155	COG1490	D-aminoacyl-tRNA deacylase activity
CVV65_RS11160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CVV65_RS11170	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CVV65_RS11175	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CVV65_RS11175	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CVV65_RS11185	COG2244	polysaccharide biosynthetic process
CVV65_RS11190	COG2323	membrane
CVV65_RS11200	COG1862	Preprotein translocase
CVV65_RS11205	COG0343	queuine tRNA-ribosyltransferase activity
CVV65_RS11210	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CVV65_RS11215	COG2133	pyrroloquinoline quinone binding
CVV65_RS11215	COG5183	chlorophyll binding
CVV65_RS11220	COG1191	sigma factor activity
CVV65_RS11230	COG2255	four-way junction helicase activity
CVV65_RS11235	COG0632	four-way junction helicase activity
CVV65_RS11240	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CVV65_RS11250	COG0217	transcriptional regulatory protein
CVV65_RS11260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CVV65_RS11260	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CVV65_RS11295	COG4569	acetaldehyde dehydrogenase (acetylating) activity
CVV65_RS11320	COG2267	carboxylic ester hydrolase activity
CVV65_RS11355	COG1414	Transcriptional regulator
CVV65_RS11360	COG3384	dioxygenase
CVV65_RS11400	COG0411	ABC transporter
CVV65_RS11410	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CVV65_RS11420	COG0531	amino acid
CVV65_RS11435	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CVV65_RS11445	COG0537	adenosine 5'-monophosphoramidase activity
CVV65_RS11450	COG0546	phosphoglycolate phosphatase activity
CVV65_RS11450	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CVV65_RS11460	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CVV65_RS11470	COG0440	acetolactate synthase activity
CVV65_RS11475	COG0028	Belongs to the TPP enzyme family
CVV65_RS11480	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CVV65_RS11485	COG0077	Prephenate dehydratase
CVV65_RS11490	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CVV65_RS11495	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CVV65_RS11500	COG0460	homoserine dehydrogenase
CVV65_RS11515	COG3344	reverse transcriptase
CVV65_RS11550	COG3344	reverse transcriptase
CVV65_RS11590	COG0318	PFAM AMP-dependent synthetase and ligase
CVV65_RS11610	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CVV65_RS11615	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CVV65_RS11620	COG1193	negative regulation of DNA recombination
CVV65_RS11630	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CVV65_RS11635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CVV65_RS11635	COG0072	phenylalanine-tRNA ligase activity
CVV65_RS11640	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CVV65_RS11650	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CVV65_RS11655	COG0569	domain protein
CVV65_RS11660	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CVV65_RS11665	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CVV65_RS11670	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CVV65_RS11680	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CVV65_RS11725	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CVV65_RS11730	COG1388	LysM domain
CVV65_RS11730	COG0791	NLP P60 protein
CVV65_RS11730	COG3103	Sh3 type 3 domain protein
CVV65_RS11750	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CVV65_RS11755	COG1024	Enoyl-CoA hydratase
CVV65_RS11765	COG0789	Transcriptional regulator
CVV65_RS11780	COG0306	phosphate transporter
CVV65_RS11785	COG1392	Phosphate transport regulator
CVV65_RS11790	COG0739	heme binding
CVV65_RS11800	COG2244	polysaccharide biosynthetic process
CVV65_RS11810	COG0517	IMP dehydrogenase activity
CVV65_RS11825	COG0372	Belongs to the citrate synthase family
CVV65_RS11830	COG0314	molybdopterin synthase activity
CVV65_RS11840	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CVV65_RS11845	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CVV65_RS11850	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CVV65_RS11855	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CVV65_RS11875	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CVV65_RS11880	COG0066	3-isopropylmalate dehydratase activity
CVV65_RS11890	COG3842	ATPase activity
CVV65_RS11895	COG3835	regulator
CVV65_RS11910	COG0508	dehydrogenase complex catalyzes the overall conversion of
CVV65_RS11915	COG0022	dehydrogenase e1 component
CVV65_RS11920	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CVV65_RS11925	COG3284	Transcriptional regulator
CVV65_RS11940	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CVV65_RS11950	COG0776	regulation of translation
CVV65_RS11955	COG0318	PFAM AMP-dependent synthetase and ligase
CVV65_RS11965	COG1187	pseudouridine synthase activity
CVV65_RS11970	COG0372	Belongs to the citrate synthase family
CVV65_RS11975	COG1842	Phage shock protein A
CVV65_RS11995	COG1556	Lactate utilization protein
CVV65_RS12000	COG1139	Iron-sulfur cluster binding protein
CVV65_RS12005	COG0247	lactate metabolic process
CVV65_RS12010	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CVV65_RS12015	COG1121	(ABC) transporter
CVV65_RS12020	COG0803	Belongs to the bacterial solute-binding protein 9 family
CVV65_RS12025	COG0735	belongs to the Fur family
CVV65_RS12045	COG0477	Major facilitator Superfamily
CVV65_RS12050	COG1595	DNA-templated transcription, initiation
CVV65_RS12060	COG0840	transmembrane signaling receptor activity
CVV65_RS12060	COG3290	protein histidine kinase activity
CVV65_RS12065	COG1940	carbohydrate kinase activity
CVV65_RS12075	COG0741	lytic transglycosylase activity
CVV65_RS12075	COG0739	heme binding
CVV65_RS12075	COG1196	nuclear chromosome segregation
CVV65_RS12080	COG0237	dephospho-CoA kinase activity
CVV65_RS12085	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CVV65_RS12095	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CVV65_RS12095	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CVV65_RS12100	COG4166	transmembrane transport
CVV65_RS12105	COG0039	L-malate dehydrogenase activity
CVV65_RS12110	COG0538	isocitrate dehydrogenase activity
CVV65_RS12120	COG0205	6-phosphofructokinase activity
CVV65_RS12125	COG0825	malonyl-CoA metabolic process
CVV65_RS12130	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CVV65_RS12140	COG0281	malic enzyme
CVV65_RS12145	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CVV65_RS12150	COG0587	DNA-directed DNA polymerase activity
CVV65_RS12155	COG4109	DRTGG domain
CVV65_RS12160	COG0824	Thioesterase
CVV65_RS12175	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CVV65_RS12180	COG3858	chitin binding
CVV65_RS12185	COG4399	Belongs to the UPF0754 family
CVV65_RS12200	COG1021	2,3-dihydroxybenzoate-AMP ligase
CVV65_RS12205	COG1028	Short-chain dehydrogenase reductase Sdr
CVV65_RS12215	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CVV65_RS12220	COG0028	Belongs to the TPP enzyme family
CVV65_RS12225	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CVV65_RS12230	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CVV65_RS12240	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CVV65_RS12245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVV65_RS12250	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CVV65_RS12255	COG1960	acyl-CoA dehydrogenase activity
CVV65_RS12260	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CVV65_RS12270	COG1164	Oligoendopeptidase f
CVV65_RS12280	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CVV65_RS12290	COG3424	synthase
CVV65_RS12295	COG1755	Isoprenylcysteine carboxyl methyltransferase
CVV65_RS12320	COG1683	Conserved Protein
CVV65_RS12325	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CVV65_RS12335	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CVV65_RS12340	COG4647	ligase activity
CVV65_RS12345	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
CVV65_RS12350	COG0145	ligase activity
CVV65_RS12355	COG3284	Transcriptional regulator
CVV65_RS12360	COG1914	H( )-stimulated, divalent metal cation uptake system
CVV65_RS12365	COG1028	Short-chain dehydrogenase reductase Sdr
CVV65_RS12370	COG0437	4 iron, 4 sulfur cluster binding
CVV65_RS12375	COG0243	molybdopterin cofactor binding
CVV65_RS12380	COG0730	response to heat
CVV65_RS12385	COG0737	Belongs to the 5'-nucleotidase family
CVV65_RS12390	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CVV65_RS12395	COG2197	response regulator
CVV65_RS12400	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CVV65_RS12415	COG0509	glycine decarboxylation via glycine cleavage system
CVV65_RS12420	COG0095	Lipoate-protein ligase
CVV65_RS12425	COG2210	Belongs to the sulfur carrier protein TusA family
CVV65_RS12445	COG0425	Belongs to the sulfur carrier protein TusA family
CVV65_RS12455	COG0509	glycine decarboxylation via glycine cleavage system
CVV65_RS12460	COG0509	glycine decarboxylation via glycine cleavage system
CVV65_RS12465	COG2181	nitrate reductase activity
CVV65_RS12465	COG0247	lactate metabolic process
CVV65_RS12470	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CVV65_RS12480	COG2181	nitrate reductase activity
CVV65_RS12480	COG0247	lactate metabolic process
CVV65_RS12505	COG2719	SpoVR family
CVV65_RS12510	COG2718	Belongs to the UPF0229 family
CVV65_RS12515	COG2766	serine protein kinase
CVV65_RS12530	COG1376	ErfK ybiS ycfS ynhG family protein
CVV65_RS12560	COG5002	protein histidine kinase activity
CVV65_RS12565	COG0745	RESPONSE REGULATOR receiver
CVV65_RS12570	COG0581	inorganic phosphate transmembrane transporter activity
CVV65_RS12575	COG0573	inorganic phosphate transmembrane transporter activity
CVV65_RS12580	COG0704	Plays a role in the regulation of phosphate uptake
CVV65_RS12585	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CVV65_RS12590	COG0745	RESPONSE REGULATOR receiver
CVV65_RS12605	COG0668	transmembrane transport
CVV65_RS12615	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CVV65_RS12630	COG1414	Transcriptional regulator
CVV65_RS12635	COG0538	isocitrate dehydrogenase activity
CVV65_RS12645	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CVV65_RS12650	COG0328	RNA-DNA hybrid ribonuclease activity
CVV65_RS12655	COG0436	Aminotransferase
CVV65_RS12690	COG2814	Major facilitator Superfamily
CVV65_RS12700	COG1131	(ABC) transporter
CVV65_RS12705	COG1846	Transcriptional regulator
CVV65_RS12715	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CVV65_RS12725	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVV65_RS12730	COG1028	Short-chain dehydrogenase reductase Sdr
CVV65_RS12755	COG0535	radical SAM domain protein
CVV65_RS12760	COG0535	radical SAM domain protein
CVV65_RS12770	COG3344	reverse transcriptase
CVV65_RS12785	COG0765	amino acid transport
CVV65_RS12795	COG0765	amino acid transport
CVV65_RS12805	COG0668	transmembrane transport
CVV65_RS12830	COG0463	Glycosyl transferase, family 2
CVV65_RS12845	COG0675	Transposase, IS605 OrfB family
CVV65_RS12850	COG0745	RESPONSE REGULATOR receiver
CVV65_RS12855	COG1999	signal sequence binding
CVV65_RS12865	COG4493	Belongs to the UPF0637 family
CVV65_RS12870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CVV65_RS12875	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CVV65_RS12895	COG2217	Heavy metal translocating P-type atpase
CVV65_RS12910	COG0156	8-amino-7-oxononanoate synthase activity
CVV65_RS12915	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CVV65_RS12940	COG0675	Transposase, IS605 OrfB family
CVV65_RS12950	COG0840	transmembrane signaling receptor activity
CVV65_RS12955	COG0039	L-malate dehydrogenase activity
CVV65_RS12970	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
CVV65_RS12980	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CVV65_RS12985	COG1012	belongs to the aldehyde dehydrogenase family
CVV65_RS12985	COG1454	alcohol dehydrogenase
CVV65_RS12990	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CVV65_RS13000	COG4302	ethanolamine ammonia-lyase activity
CVV65_RS13005	COG4303	Ethanolamine ammonia lyase large subunit
CVV65_RS13025	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CVV65_RS13030	COG4810	utilization protein
CVV65_RS13040	COG1741	Belongs to the pirin family
CVV65_RS13045	COG1028	Short-chain dehydrogenase reductase Sdr
CVV65_RS13050	COG3557	Belongs to the UPF0374 family
CVV65_RS13055	COG0628	permease
CVV65_RS13065	COG0438	transferase activity, transferring glycosyl groups
CVV65_RS13080	COG2096	Adenosyltransferase
CVV65_RS13100	COG0351	phosphomethylpyrimidine kinase
CVV65_RS13100	COG0352	thiamine-phosphate diphosphorylase activity
CVV65_RS13110	COG1414	Transcriptional regulator
CVV65_RS13115	COG1620	l-lactate permease
CVV65_RS13120	COG0277	FAD linked oxidase domain protein
CVV65_RS13125	COG0247	lactate metabolic process
CVV65_RS13130	COG0277	FAD linked oxidase domain protein
CVV65_RS13145	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CVV65_RS13150	COG0746	molybdenum cofactor guanylyltransferase activity
CVV65_RS13205	COG1489	DNA binding
CVV65_RS13210	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CVV65_RS13210	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CVV65_RS13215	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CVV65_RS13220	COG0318	PFAM AMP-dependent synthetase and ligase
CVV65_RS13225	COG2346	COG2346, Truncated hemoglobins
CVV65_RS13240	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CVV65_RS13250	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CVV65_RS13260	COG4235	cytochrome complex assembly
CVV65_RS13260	COG3088	subunit of a heme lyase
CVV65_RS13285	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CVV65_RS13295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CVV65_RS13320	COG5002	protein histidine kinase activity
CVV65_RS13325	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CVV65_RS13345	COG2217	Heavy metal translocating P-type atpase
CVV65_RS13360	COG0675	Transposase, IS605 OrfB family
CVV65_RS13410	COG1305	Transglutaminase-like
CVV65_RS13455	COG1337	RAMP superfamily
CVV65_RS13520	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CVV65_RS13525	COG1518	maintenance of DNA repeat elements
CVV65_RS13655	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CVV65_RS13660	COG1518	maintenance of DNA repeat elements
CVV65_RS13695	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CVV65_RS13705	COG1309	transcriptional regulator
CVV65_RS13710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CVV65_RS13715	COG1131	(ABC) transporter
CVV65_RS13720	COG0842	Transport permease protein
CVV65_RS13735	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CVV65_RS13740	COG0390	transport system, permease component
CVV65_RS13745	COG0697	spore germination
CVV65_RS13750	COG0675	Transposase, IS605 OrfB family
CVV65_RS13760	COG1113	amino acid transport
CVV65_RS13765	COG0436	Aminotransferase
CVV65_RS13775	COG0861	Integral membrane protein TerC family
CVV65_RS13780	COG0778	Nitroreductase
CVV65_RS13825	COG0675	Transposase, IS605 OrfB family
CVV65_RS13855	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CVV65_RS13860	COG1518	maintenance of DNA repeat elements
CVV65_RS13900	COG1111	helicase
CVV65_RS13900	COG1205	dead DEAH box helicase
CVV65_RS13905	COG2378	regulation of single-species biofilm formation
CVV65_RS13915	COG4585	Histidine kinase
CVV65_RS13935	COG3608	succinylglutamate desuccinylase aspartoacylase
CVV65_RS13935	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CVV65_RS13945	COG0542	response to heat
CVV65_RS13955	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CVV65_RS13980	COG1879	ABC-type sugar transport system periplasmic component
CVV65_RS13985	COG0154	amidase activity
CVV65_RS14000	COG0444	Belongs to the ABC transporter superfamily
CVV65_RS14005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVV65_RS14010	COG0601	transmembrane transport
CVV65_RS14015	COG0747	negative chemotaxis
CVV65_RS14040	COG0477	Major facilitator Superfamily
CVV65_RS14070	COG1566	PFAM secretion protein HlyD family protein
CVV65_RS14075	COG2814	Major facilitator Superfamily
CVV65_RS14085	COG1752	Esterase of the alpha-beta hydrolase superfamily
CVV65_RS14090	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CVV65_RS14100	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CVV65_RS14105	COG0154	amidase activity
CVV65_RS14110	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CVV65_RS14115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CVV65_RS14120	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CVV65_RS14135	COG4496	protein, YerC YecD
CVV65_RS14140	COG1024	Enoyl-CoA hydratase
CVV65_RS14145	COG1396	sequence-specific DNA binding
CVV65_RS14150	COG3620	sequence-specific DNA binding
CVV65_RS14165	COG0653	protein targeting
CVV65_RS14175	COG1278	Cold shock
CVV65_RS14185	COG0765	amino acid transport
CVV65_RS14195	COG1984	allophanate hydrolase subunit 2
CVV65_RS14200	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CVV65_RS14220	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CVV65_RS14230	COG0697	spore germination
CVV65_RS14235	COG0583	DNA-binding transcription factor activity
CVV65_RS14240	COG2814	Major facilitator Superfamily
CVV65_RS14290	COG2814	Major facilitator Superfamily
CVV65_RS14300	COG3858	chitin binding
CVV65_RS14300	COG1388	LysM domain
CVV65_RS14305	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CVV65_RS14320	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CVV65_RS14325	COG0126	phosphoglycerate kinase activity
CVV65_RS14340	COG0572	uridine kinase
CVV65_RS14350	COG1494	fructose-1,6-bisphosphatase
CVV65_RS14355	COG1850	ribulose-bisphosphate carboxylase activity
CVV65_RS14370	COG0492	ferredoxin-NADP+ reductase activity
CVV65_RS14380	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVV65_RS14385	COG0698	ribose 5-phosphate isomerase
CVV65_RS14390	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVV65_RS14395	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVV65_RS14400	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVV65_RS14410	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CVV65_RS14415	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVV65_RS14425	COG0713	ATP synthesis coupled electron transport
CVV65_RS14430	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CVV65_RS14435	COG1007	ATP synthesis coupled electron transport
CVV65_RS14445	COG1484	DNA-dependent DNA replication
CVV65_RS14465	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CVV65_RS14470	COG5001	Diguanylate cyclase
CVV65_RS14475	COG0840	transmembrane signaling receptor activity
CVV65_RS14480	COG0840	transmembrane signaling receptor activity
CVV65_RS14530	COG0076	glutamate decarboxylase activity
CVV65_RS14540	COG0583	DNA-binding transcription factor activity
CVV65_RS14555	COG1598	PFAM Uncharacterised protein family UPF0150
CVV65_RS14575	COG3328	transposase activity
CVV65_RS14620	COG3344	reverse transcriptase
CVV65_RS14630	COG4372	Transposase
CVV65_RS14695	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CVV65_RS14700	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CVV65_RS14715	COG1256	bacterial-type flagellum assembly
CVV65_RS14715	COG4786	Flagellar basal body rod
CVV65_RS14735	COG1078	dGTPase activity
CVV65_RS14750	COG0531	amino acid
CVV65_RS14755	COG0531	amino acid
CVV65_RS14765	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CVV65_RS14780	COG1307	EDD domain protein, DegV family
CVV65_RS14785	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CVV65_RS14800	COG2197	response regulator
CVV65_RS14805	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CVV65_RS14815	COG1316	TRANSCRIPTIONal
CVV65_RS14820	COG0726	polysaccharide deacetylase
CVV65_RS14830	COG0840	transmembrane signaling receptor activity
CVV65_RS14850	COG2070	2-Nitropropane dioxygenase
CVV65_RS14875	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CVV65_RS14880	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CVV65_RS14885	COG1316	TRANSCRIPTIONal
CVV65_RS14890	COG1113	amino acid transport
CVV65_RS14895	COG2199	diguanylate cyclase activity
CVV65_RS14895	COG2200	EAL domain
CVV65_RS14905	COG2508	Transcriptional regulator
CVV65_RS14910	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CVV65_RS14925	COG0531	amino acid
CVV65_RS14940	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CVV65_RS14955	COG1172	Belongs to the binding-protein-dependent transport system permease family
CVV65_RS14970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CVV65_RS14985	COG0697	spore germination
CVV65_RS14995	COG1802	Transcriptional regulator
CVV65_RS15005	COG1024	Enoyl-CoA hydratase
CVV65_RS15010	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CVV65_RS15015	COG0477	Major facilitator Superfamily
CVV65_RS15020	COG3191	aminopeptidase activity
CVV65_RS15030	COG4684	Psort location CytoplasmicMembrane, score
CVV65_RS15035	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CVV65_RS15040	COG1122	ATPase activity
CVV65_RS15085	COG0750	zinc metalloprotease
CVV65_RS15150	COG3344	reverse transcriptase
CVV65_RS15160	COG3344	reverse transcriptase
CVV65_RS15175	COG0473	3-isopropylmalate dehydrogenase activity
CVV65_RS15180	COG3829	transcription factor binding
CVV65_RS15180	COG3290	protein histidine kinase activity
CVV65_RS15190	COG2808	Putative FMN-binding domain
CVV65_RS15200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CVV65_RS15210	COG0683	leucine binding
CVV65_RS15225	COG0411	ABC transporter
CVV65_RS15275	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CVV65_RS15280	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CVV65_RS15290	COG1012	belongs to the aldehyde dehydrogenase family
CVV65_RS15305	COG0613	PHP domain protein
CVV65_RS15310	COG0804	urea catabolic process
CVV65_RS15315	COG4778	phosphonate C-P lyase system protein PhnL
CVV65_RS15320	COG4107	phosphonate C-P lyase system protein PhnK
CVV65_RS15325	COG3627	carbon phosphorus lyase activity
CVV65_RS15350	COG3454	Phosphonate metabolism
CVV65_RS15360	COG3639	organic phosphonate transmembrane transporter activity
CVV65_RS15370	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CVV65_RS15385	COG0318	PFAM AMP-dependent synthetase and ligase
CVV65_RS15395	COG0697	spore germination
CVV65_RS15405	COG2814	Major facilitator Superfamily
CVV65_RS15410	COG1566	PFAM secretion protein HlyD family protein
CVV65_RS15420	COG1846	Transcriptional regulator
CVV65_RS15425	COG0285	dihydrofolate synthase activity
CVV65_RS15430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CVV65_RS15445	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CVV65_RS15450	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CVV65_RS15455	COG1459	type II secretion system
CVV65_RS15465	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CVV65_RS15510	COG2135	peptidase activity
CVV65_RS15515	COG1363	Peptidase, m42
CVV65_RS15540	COG1216	Glycosyl transferase, family 2
CVV65_RS15550	COG1668	transmembrane transport
CVV65_RS15555	COG4555	ABC transporter
CVV65_RS15560	COG0438	transferase activity, transferring glycosyl groups
CVV65_RS15570	COG2911	Protein conserved in bacteria
CVV65_RS15570	COG3266	domain, Protein
CVV65_RS15570	COG1361	Conserved repeat domain
CVV65_RS15595	COG0604	alcohol dehydrogenase
CVV65_RS15625	COG1028	Short-chain dehydrogenase reductase Sdr
CVV65_RS15640	COG0489	protein tyrosine kinase activity
CVV65_RS15665	COG2814	Major facilitator Superfamily
CVV65_RS15675	COG1566	PFAM secretion protein HlyD family protein
CVV65_RS15690	COG0438	transferase activity, transferring glycosyl groups
CVV65_RS15770	COG0675	Transposase, IS605 OrfB family
CVV65_RS15805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CVV65_RS15810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CVV65_RS15815	COG1739	Uncharacterized protein family UPF0029
CVV65_RS15830	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CVV65_RS15840	COG4786	Flagellar basal body rod
CVV65_RS15845	COG4786	Flagellar basal body rod
CVV65_RS15850	COG1609	Transcriptional regulator
CVV65_RS15860	COG2385	sporulation resulting in formation of a cellular spore
CVV65_RS15880	COG0840	transmembrane signaling receptor activity
CVV65_RS15890	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CVV65_RS15905	COG2223	nitrite transmembrane transporter activity
CVV65_RS15910	COG1007	ATP synthesis coupled electron transport
CVV65_RS15915	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVV65_RS15920	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CVV65_RS15925	COG0713	ATP synthesis coupled electron transport
CVV65_RS15930	COG0839	Belongs to the complex I subunit 6 family
CVV65_RS15940	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CVV65_RS15945	COG0649	NAD binding
CVV65_RS15950	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVV65_RS15955	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVV65_RS15960	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVV65_RS15965	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CVV65_RS15975	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CVV65_RS15980	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CVV65_RS15985	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CVV65_RS15990	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CVV65_RS15995	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CVV65_RS16020	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CVV65_RS16025	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CVV65_RS16030	COG4475	Protein of unknown function (DUF436)
CVV65_RS16035	COG0698	ribose 5-phosphate isomerase
CVV65_RS16045	COG2391	methyltransferase activity
CVV65_RS16055	COG3284	Transcriptional regulator
CVV65_RS16060	COG0145	ligase activity
CVV65_RS16065	COG4647	ligase activity
CVV65_RS16070	COG0145	ligase activity
CVV65_RS16075	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
CVV65_RS16085	COG0318	PFAM AMP-dependent synthetase and ligase
CVV65_RS16090	COG0183	Belongs to the thiolase family
CVV65_RS16095	COG0428	transporter
CVV65_RS16100	COG1971	Probably functions as a manganese efflux pump
CVV65_RS16105	COG0009	L-threonylcarbamoyladenylate synthase
CVV65_RS16115	COG2890	protein-(glutamine-N5) methyltransferase activity
CVV65_RS16120	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CVV65_RS16135	COG0254	rRNA binding
CVV65_RS16145	COG1929	Belongs to the glycerate kinase type-1 family
CVV65_RS16150	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CVV65_RS16155	COG1494	fructose-1,6-bisphosphatase
CVV65_RS16165	COG1473	amidohydrolase
CVV65_RS16170	COG2171	N-acyltransferase activity
CVV65_RS16180	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CVV65_RS16195	COG0504	CTP synthase activity
CVV65_RS16200	COG3343	RNA polymerase activity
CVV65_RS16210	COG1960	acyl-CoA dehydrogenase activity
CVV65_RS16215	COG1960	acyl-CoA dehydrogenase activity
CVV65_RS16220	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVV65_RS16225	COG0183	Belongs to the thiolase family
CVV65_RS16230	COG0247	lactate metabolic process
CVV65_RS16230	COG2181	nitrate reductase activity
CVV65_RS16240	COG0018	arginyl-trna synthetase
CVV65_RS16250	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CVV65_RS16255	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CVV65_RS16290	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CVV65_RS16295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CVV65_RS16305	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CVV65_RS16335	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CVV65_RS16340	COG0849	cell division
CVV65_RS16345	COG0305	Participates in initiation and elongation during chromosome replication
CVV65_RS16350	COG0359	binds to the 23S rRNA
CVV65_RS16360	COG0028	Belongs to the TPP enzyme family
CVV65_RS16365	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CVV65_RS16370	COG0629	single-stranded DNA binding
CVV65_RS16375	COG0360	Binds together with S18 to 16S ribosomal RNA
CVV65_RS16380	COG0012	GTP binding
CVV65_RS16385	COG4481	Protein conserved in bacteria
CVV65_RS16400	COG1597	lipid kinase activity
CVV65_RS16410	COG1811	Na channel or pump
CVV65_RS16415	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CVV65_RS16420	COG1475	DNA binding
CVV65_RS16425	COG1192	Involved in chromosome partitioning
CVV65_RS16430	COG1475	DNA binding
CVV65_RS16435	COG0357	Ribosomal RNA small subunit methyltransferase G
CVV65_RS16440	COG0445	tRNA wobble uridine modification
CVV65_RS16450	COG0706	membrane insertase activity
CVV65_RS16455	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CVV65_RS16460	COG0594	ribonuclease P activity
CVV65_RS16465	COG0230	Belongs to the bacterial ribosomal protein bL34 family