locus-tag	class	description
FZC33_RS00025	COG0288	reversible hydration of carbon dioxide
FZC33_RS00035	COG2223	nitrite transmembrane transporter activity
FZC33_RS00040	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
FZC33_RS00045	COG1140	nitrate reductase beta subunit
FZC33_RS00050	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
FZC33_RS00055	COG2181	nitrate reductase activity
FZC33_RS00060	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FZC33_RS00100	COG0758	DNA mediated transformation
FZC33_RS00110	COG0758	DNA mediated transformation
FZC33_RS00165	COG1431	PFAM Stem cell self-renewal protein Piwi
FZC33_RS00185	COG2433	Pfam Transposase IS66
FZC33_RS00190	COG3436	PFAM IS66 Orf2 family protein
FZC33_RS00260	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FZC33_RS00290	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FZC33_RS00380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FZC33_RS00410	COG4957	zinc ion binding
FZC33_RS00420	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FZC33_RS00465	COG2207	Transcriptional regulator
FZC33_RS00545	COG0071	Belongs to the small heat shock protein (HSP20) family
FZC33_RS00570	COG0071	Belongs to the small heat shock protein (HSP20) family
FZC33_RS00575	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FZC33_RS00580	COG0459	protein refolding
FZC33_RS00595	COG4962	Type ii secretion system protein e
FZC33_RS00690	COG3685	Protein conserved in bacteria
FZC33_RS00705	COG0753	catalase activity
FZC33_RS00715	COG3920	Histidine kinase
FZC33_RS00760	COG0500	methyltransferase
FZC33_RS00795	COG3459	Glycosyltransferase 36 associated
FZC33_RS00800	COG1278	Cold shock
FZC33_RS00820	COG0459	protein refolding
FZC33_RS00870	COG0028	Belongs to the TPP enzyme family
FZC33_RS00875	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FZC33_RS00880	COG1653	transport
FZC33_RS00885	COG1175	transmembrane transport
FZC33_RS00890	COG0395	ABC-type sugar transport system, permease component
FZC33_RS00920	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS00925	COG1129	ABC transporter
FZC33_RS00930	COG4166	transmembrane transport
FZC33_RS00945	COG0444	Belongs to the ABC transporter superfamily
FZC33_RS00970	COG1129	ABC transporter
FZC33_RS00975	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS01040	COG1063	alcohol dehydrogenase
FZC33_RS01050	COG1733	regulation of RNA biosynthetic process
FZC33_RS01060	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS01070	COG0583	DNA-binding transcription factor activity
FZC33_RS01075	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FZC33_RS01080	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FZC33_RS01080	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FZC33_RS01090	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FZC33_RS01090	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FZC33_RS01100	COG0318	PFAM AMP-dependent synthetase and ligase
FZC33_RS01105	COG0683	leucine binding
FZC33_RS01125	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FZC33_RS01130	COG2086	electron transfer activity
FZC33_RS01145	COG2084	Dehydrogenase
FZC33_RS01160	COG0251	oxidation-reduction process
FZC33_RS01165	COG2186	Transcriptional regulator
FZC33_RS01170	COG4221	oxidoreductase activity
FZC33_RS01175	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS01185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FZC33_RS01190	COG4597	amino acid ABC transporter
FZC33_RS01195	COG0765	amino acid transport
FZC33_RS01200	COG1126	abc transporter atp-binding protein
FZC33_RS01205	COG0277	FAD linked oxidase domain protein
FZC33_RS01210	COG0028	Belongs to the TPP enzyme family
FZC33_RS01225	COG0436	Aminotransferase
FZC33_RS01230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FZC33_RS01240	COG0006	proline dipeptidase activity
FZC33_RS01245	COG3608	succinylglutamate desuccinylase aspartoacylase
FZC33_RS01265	COG1126	abc transporter atp-binding protein
FZC33_RS01305	COG0477	Major facilitator Superfamily
FZC33_RS01355	COG0071	Belongs to the small heat shock protein (HSP20) family
FZC33_RS01365	COG1051	belongs to the nudix hydrolase family
FZC33_RS01370	COG2217	Heavy metal translocating P-type atpase
FZC33_RS01380	COG1131	(ABC) transporter
FZC33_RS01390	COG0842	Transport permease protein
FZC33_RS01395	COG1129	ABC transporter
FZC33_RS01395	COG0842	Transport permease protein
FZC33_RS01400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FZC33_RS01420	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FZC33_RS01430	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FZC33_RS01525	COG2197	response regulator
FZC33_RS01530	COG0583	DNA-binding transcription factor activity
FZC33_RS01610	COG0830	nickel cation binding
FZC33_RS01615	COG0832	Belongs to the urease beta subunit family
FZC33_RS01615	COG0831	urea catabolic process
FZC33_RS01620	COG0804	urea catabolic process
FZC33_RS01625	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FZC33_RS01630	COG0829	nickel cation binding
FZC33_RS01655	COG2824	Alkylphosphonate utilization operon protein PhnA
FZC33_RS01665	COG3260	NADH ubiquinone oxidoreductase 20
FZC33_RS01670	COG0649	NAD binding
FZC33_RS01675	COG0651	ATP synthesis coupled electron transport
FZC33_RS01685	COG0650	Formate hydrogenlyase subunit 4
FZC33_RS01690	COG0651	ATP synthesis coupled electron transport
FZC33_RS01705	COG0765	amino acid transport
FZC33_RS01710	COG1126	abc transporter atp-binding protein
FZC33_RS01730	COG2079	MmgE PrpD family protein
FZC33_RS01735	COG0165	Argininosuccinate lyase
FZC33_RS01740	COG0583	DNA-binding transcription factor activity
FZC33_RS01755	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS01805	COG2271	Major facilitator Superfamily
FZC33_RS01840	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FZC33_RS01855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FZC33_RS01875	COG1596	polysaccharide export
FZC33_RS01900	COG0438	transferase activity, transferring glycosyl groups
FZC33_RS01905	COG0438	transferase activity, transferring glycosyl groups
FZC33_RS01945	COG4957	zinc ion binding
FZC33_RS01975	COG0438	transferase activity, transferring glycosyl groups
FZC33_RS02015	COG1560	Kdo2-lipid A biosynthetic process
FZC33_RS02015	COG4783	chaperone-mediated protein folding
FZC33_RS02020	COG1733	regulation of RNA biosynthetic process
FZC33_RS02040	COG1573	uracil-dna glycosylase
FZC33_RS02060	COG1129	ABC transporter
FZC33_RS02070	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS02075	COG3959	Transketolase, thiamine diphosphate binding domain
FZC33_RS02080	COG3958	Transketolase
FZC33_RS02085	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FZC33_RS02090	COG2390	Transcriptional regulator
FZC33_RS02100	COG2390	Transcriptional regulator
FZC33_RS02115	COG0583	DNA-binding transcription factor activity
FZC33_RS02120	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS02120	COG3321	synthase
FZC33_RS02120	COG0604	alcohol dehydrogenase
FZC33_RS02125	COG1335	isochorismatase
FZC33_RS02140	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
FZC33_RS02150	COG1482	cell wall glycoprotein biosynthetic process
FZC33_RS02165	COG1278	Cold shock
FZC33_RS02195	COG4977	sequence-specific DNA binding
FZC33_RS02255	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FZC33_RS02270	COG1129	ABC transporter
FZC33_RS02275	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS02300	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FZC33_RS02310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FZC33_RS02320	COG0747	negative chemotaxis
FZC33_RS02330	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FZC33_RS02335	COG1454	alcohol dehydrogenase
FZC33_RS02345	COG3395	kinase activity
FZC33_RS02370	COG1309	transcriptional regulator
FZC33_RS02395	COG0745	RESPONSE REGULATOR receiver
FZC33_RS02400	COG5002	protein histidine kinase activity
FZC33_RS02415	COG1073	alpha beta
FZC33_RS02435	COG0431	NADPH-dependent FMN reductase
FZC33_RS02455	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS02475	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FZC33_RS02475	COG0646	methionine synthase
FZC33_RS02480	COG0765	amino acid transport
FZC33_RS02485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FZC33_RS02500	COG2011	ABC-type metal ion transport system permease component
FZC33_RS02510	COG1609	Transcriptional regulator
FZC33_RS02520	COG1175	transmembrane transport
FZC33_RS02525	COG0395	ABC-type sugar transport system, permease component
FZC33_RS02535	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FZC33_RS02575	COG0544	peptidyl-prolyl cis-trans isomerase activity
FZC33_RS02580	COG0793	Belongs to the peptidase S41A family
FZC33_RS02585	COG1442	glycosyl transferase family 8
FZC33_RS02620	COG3385	transposase activity
FZC33_RS02640	COG1522	sequence-specific DNA binding
FZC33_RS02650	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FZC33_RS02680	COG1301	dicarboxylic acid transport
FZC33_RS02705	COG1175	transmembrane transport
FZC33_RS02720	COG2188	Transcriptional regulator
FZC33_RS02730	COG1802	Transcriptional regulator
FZC33_RS02735	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FZC33_RS02740	COG0402	S-adenosylhomocysteine deaminase activity
FZC33_RS02755	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FZC33_RS02760	COG1070	Carbohydrate kinase
FZC33_RS02765	COG1349	DNA-binding transcription factor activity
FZC33_RS02770	COG0235	Class ii aldolase
FZC33_RS02775	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS02790	COG1175	transmembrane transport
FZC33_RS02800	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS02820	COG1309	transcriptional regulator
FZC33_RS02830	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS02835	COG1129	ABC transporter
FZC33_RS02840	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS02845	COG1063	alcohol dehydrogenase
FZC33_RS02850	COG1012	belongs to the aldehyde dehydrogenase family
FZC33_RS02860	COG0656	L-ascorbic acid biosynthetic process
FZC33_RS02870	COG1024	Enoyl-CoA hydratase
FZC33_RS02900	COG1960	acyl-CoA dehydrogenase activity
FZC33_RS02920	COG1609	Transcriptional regulator
FZC33_RS02940	COG1175	transmembrane transport
FZC33_RS02945	COG0395	ABC-type sugar transport system, permease component
FZC33_RS02950	COG3842	ATPase activity
FZC33_RS02990	COG4942	peptidase
FZC33_RS03045	COG2197	response regulator
FZC33_RS03100	COG0726	polysaccharide deacetylase
FZC33_RS03105	COG0517	IMP dehydrogenase activity
FZC33_RS03110	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
FZC33_RS03115	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FZC33_RS03125	COG4566	intracellular signal transduction
FZC33_RS03130	COG4191	Histidine kinase
FZC33_RS03140	COG3174	membrane
FZC33_RS03145	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FZC33_RS03180	COG0793	Belongs to the peptidase S41A family
FZC33_RS03210	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
FZC33_RS03250	COG1573	uracil-dna glycosylase
FZC33_RS03265	COG0693	protein deglycase activity
FZC33_RS03285	COG3237	CsbD-like
FZC33_RS03320	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FZC33_RS03360	COG0129	dihydroxy-acid dehydratase activity
FZC33_RS03375	COG0583	DNA-binding transcription factor activity
FZC33_RS03395	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FZC33_RS03410	COG1879	ABC-type sugar transport system periplasmic component
FZC33_RS03415	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS03420	COG1129	ABC transporter
FZC33_RS03450	COG0149	triose-phosphate isomerase activity
FZC33_RS03455	COG0698	ribose 5-phosphate isomerase
FZC33_RS03460	COG2130	NADP-dependent
FZC33_RS03475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FZC33_RS03480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FZC33_RS03485	COG4336	lyase activity
FZC33_RS03490	COG4791	protein targeting
FZC33_RS03500	COG4790	Type iii secretion
FZC33_RS03505	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FZC33_RS03515	COG1157	protein secretion by the type III secretion system
FZC33_RS03585	COG4789	Type iii secretion
FZC33_RS03590	COG4964	Belongs to the GSP D family
FZC33_RS03605	COG4792	protein secretion
FZC33_RS03630	COG0745	RESPONSE REGULATOR receiver
FZC33_RS03645	COG1215	transferase activity, transferring glycosyl groups
FZC33_RS03660	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FZC33_RS03695	COG0154	amidase activity
FZC33_RS03700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FZC33_RS03720	COG0601	transmembrane transport
FZC33_RS03730	COG0647	UMP catabolic process
FZC33_RS03735	COG3971	2-oxopent-4-enoate hydratase activity
FZC33_RS03750	COG1012	belongs to the aldehyde dehydrogenase family
FZC33_RS03760	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FZC33_RS03770	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FZC33_RS03780	COG5441	Belongs to the UPF0261 family
FZC33_RS03790	COG0531	amino acid
FZC33_RS03795	COG1012	belongs to the aldehyde dehydrogenase family
FZC33_RS03830	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FZC33_RS03845	COG1846	Transcriptional regulator
FZC33_RS03850	COG2719	SpoVR family
FZC33_RS03855	COG2718	Belongs to the UPF0229 family
FZC33_RS03860	COG2766	serine protein kinase
FZC33_RS03870	COG1999	signal sequence binding
FZC33_RS03920	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FZC33_RS03930	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FZC33_RS03935	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FZC33_RS03940	COG1335	isochorismatase
FZC33_RS03950	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
FZC33_RS03960	COG1032	radical SAM domain protein
FZC33_RS03965	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FZC33_RS03970	COG2204	response regulator
FZC33_RS03975	COG3852	Histidine kinase
FZC33_RS03995	COG2076	Multidrug Resistance protein
FZC33_RS04005	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
FZC33_RS04015	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FZC33_RS04020	COG0671	phosphoesterase, PA-phosphatase related
FZC33_RS04025	COG0492	ferredoxin-NADP+ reductase activity
FZC33_RS04040	COG0596	Alpha beta hydrolase
FZC33_RS04045	COG1309	transcriptional regulator
FZC33_RS04065	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FZC33_RS04075	COG0459	protein refolding
FZC33_RS04095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FZC33_RS04100	COG2198	Histidine kinase
FZC33_RS04100	COG0784	Response regulator, receiver
FZC33_RS04100	COG2205	protein histidine kinase activity
FZC33_RS04105	COG2197	response regulator
FZC33_RS04140	COG1129	ABC transporter
FZC33_RS04145	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS04155	COG1250	3-hydroxyacyl-CoA dehydrogenase
FZC33_RS04160	COG3246	L-lysine catabolic process to acetate
FZC33_RS04165	COG3386	PFAM SMP-30 Gluconolaconase
FZC33_RS04175	COG2197	response regulator
FZC33_RS04210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FZC33_RS04220	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FZC33_RS04245	COG1984	allophanate hydrolase subunit 2
FZC33_RS04255	COG0439	Biotin carboxylase
FZC33_RS04265	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FZC33_RS04305	COG4774	siderophore transport
FZC33_RS04310	COG0840	transmembrane signaling receptor activity
FZC33_RS04335	COG2201	protein-glutamate methylesterase activity
FZC33_RS04340	COG4251	negative regulation of phosphorylation
FZC33_RS04340	COG3706	GGDEF domain
FZC33_RS04340	COG2203	Gaf domain
FZC33_RS04340	COG5001	Diguanylate cyclase
FZC33_RS04350	COG2197	response regulator
FZC33_RS04395	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS04400	COG4948	Mandelate Racemase Muconate Lactonizing
FZC33_RS04405	COG1609	Transcriptional regulator
FZC33_RS04410	COG2271	Major facilitator Superfamily
FZC33_RS04440	COG0351	phosphomethylpyrimidine kinase
FZC33_RS04450	COG1877	trehalose-phosphatase activity
FZC33_RS04455	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
FZC33_RS04460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FZC33_RS04470	COG5383	Protein conserved in bacteria
FZC33_RS04475	COG0247	lactate metabolic process
FZC33_RS04475	COG0277	FAD linked oxidase domain protein
FZC33_RS04480	COG1012	belongs to the aldehyde dehydrogenase family
FZC33_RS04485	COG0519	Catalyzes the synthesis of GMP from XMP
FZC33_RS04490	COG0110	maltose O-acetyltransferase activity
FZC33_RS04500	COG1940	carbohydrate kinase activity
FZC33_RS04510	COG0395	ABC-type sugar transport system, permease component
FZC33_RS04515	COG1175	transmembrane transport
FZC33_RS04525	COG2183	response to ionizing radiation
FZC33_RS04530	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
FZC33_RS04530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FZC33_RS04535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FZC33_RS04540	COG1169	isochorismate synthase
FZC33_RS04545	COG1021	2,3-dihydroxybenzoate-AMP ligase
FZC33_RS04550	COG3433	isochorismatase activity
FZC33_RS04550	COG1535	isochorismatase
FZC33_RS04555	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS04560	COG2375	cellular response to nickel ion
FZC33_RS04565	COG1535	isochorismatase
FZC33_RS04565	COG3433	isochorismatase activity
FZC33_RS04570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FZC33_RS04575	COG4774	siderophore transport
FZC33_RS04575	COG1629	transport
FZC33_RS04580	COG0583	DNA-binding transcription factor activity
FZC33_RS04585	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FZC33_RS04590	COG0509	glycine decarboxylation via glycine cleavage system
FZC33_RS04595	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FZC33_RS04595	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FZC33_RS04600	COG1760	l-serine dehydratase
FZC33_RS04610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FZC33_RS04615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FZC33_RS04620	COG1120	ATPase activity
FZC33_RS04630	COG1942	4-Oxalocrotonate Tautomerase
FZC33_RS04635	COG0583	DNA-binding transcription factor activity
FZC33_RS04645	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FZC33_RS04650	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
FZC33_RS04675	COG1126	abc transporter atp-binding protein
FZC33_RS04680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FZC33_RS04685	COG3938	Belongs to the proline racemase family
FZC33_RS04695	COG3938	Belongs to the proline racemase family
FZC33_RS04710	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FZC33_RS04715	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FZC33_RS04720	COG0450	alkyl hydroperoxide reductase
FZC33_RS04740	COG0559	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS04745	COG0683	leucine binding
FZC33_RS04760	COG3485	protocatechuate 3,4-dioxygenase
FZC33_RS04765	COG3485	protocatechuate 3,4-dioxygenase
FZC33_RS04770	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FZC33_RS04775	COG0596	Alpha beta hydrolase
FZC33_RS04780	COG0583	DNA-binding transcription factor activity
FZC33_RS04805	COG1278	Cold shock
FZC33_RS04815	COG0300	oxidoreductase activity
FZC33_RS04820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FZC33_RS04825	COG0842	Transport permease protein
FZC33_RS04855	COG0583	DNA-binding transcription factor activity
FZC33_RS04860	COG0596	Alpha beta hydrolase
FZC33_RS04870	COG0183	Belongs to the thiolase family
FZC33_RS04875	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FZC33_RS04885	COG1414	Transcriptional regulator
FZC33_RS04900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FZC33_RS04905	COG4521	taurine ABC transporter
FZC33_RS04910	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FZC33_RS04915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FZC33_RS04930	COG0028	Belongs to the TPP enzyme family
FZC33_RS04935	COG2855	membrane
FZC33_RS04945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FZC33_RS04965	COG4608	Belongs to the ABC transporter superfamily
FZC33_RS04970	COG0402	S-adenosylhomocysteine deaminase activity
FZC33_RS04975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FZC33_RS04980	COG0601	transmembrane transport
FZC33_RS04985	COG4533	DNA binding
FZC33_RS04990	COG0444	Belongs to the ABC transporter superfamily
FZC33_RS05005	COG0444	Belongs to the ABC transporter superfamily
FZC33_RS05015	COG0747	negative chemotaxis
FZC33_RS05020	COG0601	transmembrane transport
FZC33_RS05025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FZC33_RS05035	COG0402	S-adenosylhomocysteine deaminase activity
FZC33_RS05050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FZC33_RS05065	COG1902	pentaerythritol trinitrate reductase activity
FZC33_RS05065	COG0446	pyridine nucleotide-disulphide oxidoreductase
FZC33_RS05070	COG1902	pentaerythritol trinitrate reductase activity
FZC33_RS05070	COG0446	pyridine nucleotide-disulphide oxidoreductase
FZC33_RS05075	COG4948	Mandelate Racemase Muconate Lactonizing
FZC33_RS05080	COG0657	acetylesterase activity
FZC33_RS05110	COG1335	isochorismatase
FZC33_RS05115	COG0006	proline dipeptidase activity
FZC33_RS05125	COG5598	trimethylamine methyltransferase
FZC33_RS05145	COG2837	iron assimilation
FZC33_RS05160	COG1764	response to oxidative stress
FZC33_RS05180	COG1309	transcriptional regulator
FZC33_RS05190	COG0154	amidase activity
FZC33_RS05195	COG1122	ATPase activity
FZC33_RS05220	COG0596	Alpha beta hydrolase
FZC33_RS05225	COG0596	Alpha beta hydrolase
FZC33_RS05235	COG1755	Isoprenylcysteine carboxyl methyltransferase
FZC33_RS05245	COG0583	DNA-binding transcription factor activity
FZC33_RS05250	COG1073	alpha beta
FZC33_RS05255	COG1073	alpha beta
FZC33_RS05260	COG0702	epimerase
FZC33_RS05275	COG0259	pyridoxamine-phosphate oxidase activity
FZC33_RS05305	COG1442	glycosyl transferase family 8
FZC33_RS05305	COG1216	Glycosyl transferase, family 2
FZC33_RS05335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FZC33_RS05340	COG1136	(ABC) transporter
FZC33_RS05340	COG0577	efflux transmembrane transporter activity
FZC33_RS05345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FZC33_RS05350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FZC33_RS05365	COG1802	Transcriptional regulator
FZC33_RS05370	COG0765	amino acid transport
FZC33_RS05375	COG0765	amino acid transport
FZC33_RS05380	COG1126	abc transporter atp-binding protein
FZC33_RS05385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FZC33_RS05390	COG1063	alcohol dehydrogenase
FZC33_RS05395	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS05400	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FZC33_RS05400	COG0473	3-isopropylmalate dehydrogenase activity
FZC33_RS05405	COG2721	sulfolactate sulfo-lyase activity
FZC33_RS05410	COG2721	sulfolactate sulfo-lyase activity
FZC33_RS05430	COG0411	ABC transporter
FZC33_RS05440	COG0829	nickel cation binding
FZC33_RS05445	COG0831	urea catabolic process
FZC33_RS05455	COG0832	Belongs to the urease beta subunit family
FZC33_RS05460	COG0804	urea catabolic process
FZC33_RS05465	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
FZC33_RS05470	COG0830	nickel cation binding
FZC33_RS05475	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FZC33_RS05495	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FZC33_RS05505	COG1596	polysaccharide export
FZC33_RS05520	COG0250	Participates in transcription elongation, termination and antitermination
FZC33_RS05540	COG0367	asparagine synthase
FZC33_RS05545	COG0438	transferase activity, transferring glycosyl groups
FZC33_RS05570	COG1216	Glycosyl transferase, family 2
FZC33_RS05580	COG0297	glycogen (starch) synthase activity
FZC33_RS05615	COG0438	transferase activity, transferring glycosyl groups
FZC33_RS05625	COG2192	nodulation
FZC33_RS05660	COG1609	Transcriptional regulator
FZC33_RS05685	COG1129	ABC transporter
FZC33_RS05690	COG2084	Dehydrogenase
FZC33_RS05695	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS05700	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FZC33_RS05705	COG1063	alcohol dehydrogenase
FZC33_RS05710	COG4993	Dehydrogenase
FZC33_RS05715	COG1070	Carbohydrate kinase
FZC33_RS05725	COG1737	Transcriptional regulator
FZC33_RS05735	COG1129	ABC transporter
FZC33_RS05745	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS05805	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FZC33_RS05825	COG2186	Transcriptional regulator
FZC33_RS05830	COG0673	inositol 2-dehydrogenase activity
FZC33_RS05835	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS05840	COG1129	ABC transporter
FZC33_RS05850	COG1879	ABC-type sugar transport system periplasmic component
FZC33_RS05860	COG0287	Prephenate dehydrogenase
FZC33_RS05865	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS05870	COG4948	Mandelate Racemase Muconate Lactonizing
FZC33_RS05880	COG2017	converts alpha-aldose to the beta-anomer
FZC33_RS05885	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS05890	COG1129	ABC transporter
FZC33_RS05895	COG1879	ABC-type sugar transport system periplasmic component
FZC33_RS05900	COG2186	Transcriptional regulator
FZC33_RS05905	COG3842	ATPase activity
FZC33_RS05910	COG1177	transmembrane transport
FZC33_RS05930	COG1012	belongs to the aldehyde dehydrogenase family
FZC33_RS05935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FZC33_RS05945	COG2267	carboxylic ester hydrolase activity
FZC33_RS05960	COG2824	Alkylphosphonate utilization operon protein PhnA
FZC33_RS05965	COG3278	Belongs to the heme-copper respiratory oxidase family
FZC33_RS05980	COG2010	Cytochrome c
FZC33_RS06015	COG1176	ABC-type spermidine putrescine transport system, permease component I
FZC33_RS06025	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS06030	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS06040	COG3842	ATPase activity
FZC33_RS06045	COG0726	polysaccharide deacetylase
FZC33_RS06055	COG0523	cobalamin synthesis protein
FZC33_RS06065	COG2819	hydrolase of the alpha beta superfamily
FZC33_RS06075	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FZC33_RS06080	COG4774	siderophore transport
FZC33_RS06110	COG1486	melibiose metabolic process
FZC33_RS06120	COG1349	DNA-binding transcription factor activity
FZC33_RS06145	COG2222	sugar isomerase
FZC33_RS06150	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FZC33_RS06190	COG1278	Cold shock
FZC33_RS06195	COG4948	Mandelate Racemase Muconate Lactonizing
FZC33_RS06200	COG5598	trimethylamine methyltransferase
FZC33_RS06205	COG0583	DNA-binding transcription factor activity
FZC33_RS06215	COG1012	belongs to the aldehyde dehydrogenase family
FZC33_RS06220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FZC33_RS06230	COG4175	Glycine betaine
FZC33_RS06245	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS06255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FZC33_RS06270	COG4176	ABC-type proline glycine betaine transport system permease component
FZC33_RS06310	COG2345	Transcriptional regulator
FZC33_RS06315	COG1082	Xylose isomerase domain protein TIM barrel
FZC33_RS06320	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS06325	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS06330	COG1129	ABC transporter
FZC33_RS06345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FZC33_RS06350	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS06355	COG1129	ABC transporter
FZC33_RS06370	COG0698	ribose 5-phosphate isomerase
FZC33_RS06375	COG1129	ABC transporter
FZC33_RS06380	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS06385	COG1879	ABC-type sugar transport system periplasmic component
FZC33_RS06390	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS06395	COG2376	Dihydroxyacetone kinase
FZC33_RS06405	COG2376	Dihydroxyacetone kinase
FZC33_RS06410	COG1461	Dihydroxyacetone kinase
FZC33_RS06420	COG4221	oxidoreductase activity
FZC33_RS06440	COG0583	DNA-binding transcription factor activity
FZC33_RS06450	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FZC33_RS06470	COG0287	Prephenate dehydrogenase
FZC33_RS06470	COG1605	Chorismate mutase
FZC33_RS06495	COG3684	Belongs to the aldolase LacD family
FZC33_RS06510	COG1126	abc transporter atp-binding protein
FZC33_RS06520	COG1609	Transcriptional regulator
FZC33_RS06530	COG1349	DNA-binding transcription factor activity
FZC33_RS06540	COG1175	transmembrane transport
FZC33_RS06545	COG0395	ABC-type sugar transport system, permease component
FZC33_RS06555	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS06575	COG0673	inositol 2-dehydrogenase activity
FZC33_RS06580	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FZC33_RS06595	COG1129	ABC transporter
FZC33_RS06615	COG1609	Transcriptional regulator
FZC33_RS06630	COG0829	nickel cation binding
FZC33_RS06635	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FZC33_RS06640	COG0804	urea catabolic process
FZC33_RS06650	COG0830	nickel cation binding
FZC33_RS06695	COG3284	Transcriptional regulator
FZC33_RS06700	COG1063	alcohol dehydrogenase
FZC33_RS06720	COG3350	monooxygenase activity
FZC33_RS06725	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FZC33_RS06740	COG1063	alcohol dehydrogenase
FZC33_RS06755	COG0459	protein refolding
FZC33_RS06760	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FZC33_RS06815	COG1733	regulation of RNA biosynthetic process
FZC33_RS06820	COG0702	epimerase
FZC33_RS06825	COG1879	ABC-type sugar transport system periplasmic component
FZC33_RS06830	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS06840	COG0673	inositol 2-dehydrogenase activity
FZC33_RS06845	COG1012	belongs to the aldehyde dehydrogenase family
FZC33_RS06855	COG0673	inositol 2-dehydrogenase activity
FZC33_RS06860	COG0673	inositol 2-dehydrogenase activity
FZC33_RS06865	COG1129	ABC transporter
FZC33_RS06870	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS06885	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS06895	COG3962	Belongs to the TPP enzyme family
FZC33_RS06920	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS06925	COG1129	ABC transporter
FZC33_RS06945	COG0546	phosphoglycolate phosphatase activity
FZC33_RS06955	COG1012	belongs to the aldehyde dehydrogenase family
FZC33_RS06965	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS06980	COG0306	phosphate transporter
FZC33_RS06985	COG1392	Phosphate transport regulator
FZC33_RS06990	COG3852	Histidine kinase
FZC33_RS07000	COG1012	belongs to the aldehyde dehydrogenase family
FZC33_RS07010	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS07015	COG1129	ABC transporter
FZC33_RS07020	COG1879	ABC-type sugar transport system periplasmic component
FZC33_RS07025	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FZC33_RS07030	COG3608	succinylglutamate desuccinylase aspartoacylase
FZC33_RS07035	COG1414	Transcriptional regulator
FZC33_RS07040	COG1414	Transcriptional regulator
FZC33_RS07045	COG0765	amino acid transport
FZC33_RS07050	COG0765	amino acid transport
FZC33_RS07075	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FZC33_RS07080	COG0477	Major facilitator Superfamily
FZC33_RS07105	COG0145	ligase activity
FZC33_RS07120	COG0235	Class ii aldolase
FZC33_RS07130	COG2814	Major facilitator Superfamily
FZC33_RS07135	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FZC33_RS07165	COG0583	DNA-binding transcription factor activity
FZC33_RS07180	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS07190	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FZC33_RS07195	COG2814	Major facilitator Superfamily
FZC33_RS07200	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS07220	COG3485	protocatechuate 3,4-dioxygenase
FZC33_RS07255	COG1609	Transcriptional regulator
FZC33_RS07265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FZC33_RS07320	COG0583	DNA-binding transcription factor activity
FZC33_RS07325	COG0277	FAD linked oxidase domain protein
FZC33_RS07330	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FZC33_RS07345	COG0765	amino acid transport
FZC33_RS07355	COG0583	DNA-binding transcription factor activity
FZC33_RS07360	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FZC33_RS07370	COG1522	sequence-specific DNA binding
FZC33_RS07375	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FZC33_RS07380	COG2188	Transcriptional regulator
FZC33_RS07400	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FZC33_RS07410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FZC33_RS07420	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FZC33_RS07435	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
FZC33_RS07440	COG1920	GTP binding
FZC33_RS07445	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FZC33_RS07450	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
FZC33_RS07450	COG0778	Nitroreductase
FZC33_RS07480	COG0559	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS07500	COG0745	RESPONSE REGULATOR receiver
FZC33_RS07515	COG2197	response regulator
FZC33_RS07525	COG5002	protein histidine kinase activity
FZC33_RS07525	COG0784	Response regulator, receiver
FZC33_RS07525	COG2198	Histidine kinase
FZC33_RS07555	COG1376	ErfK ybiS ycfS ynhG family protein
FZC33_RS07570	COG0642	Histidine kinase
FZC33_RS07580	COG1126	abc transporter atp-binding protein
FZC33_RS07585	COG0765	amino acid transport
FZC33_RS07605	COG0583	DNA-binding transcription factor activity
FZC33_RS07615	COG2086	electron transfer activity
FZC33_RS07620	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FZC33_RS07625	COG0745	RESPONSE REGULATOR receiver
FZC33_RS07630	COG0583	DNA-binding transcription factor activity
FZC33_RS07635	COG3485	protocatechuate 3,4-dioxygenase
FZC33_RS07650	COG1137	ATPase activity
FZC33_RS07675	COG3485	protocatechuate 3,4-dioxygenase
FZC33_RS07690	COG1053	succinate dehydrogenase
FZC33_RS07700	COG1414	Transcriptional regulator
FZC33_RS07725	COG1574	metal-dependent hydrolase with the TIM-barrel fold
FZC33_RS07755	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FZC33_RS07755	COG1017	nitric oxide dioxygenase activity
FZC33_RS07760	COG1959	2 iron, 2 sulfur cluster binding
FZC33_RS07770	COG1879	ABC-type sugar transport system periplasmic component
FZC33_RS07775	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS07795	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS07810	COG0300	oxidoreductase activity
FZC33_RS07825	COG1309	transcriptional regulator
FZC33_RS07870	COG4608	Belongs to the ABC transporter superfamily
FZC33_RS07880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FZC33_RS07890	COG0747	negative chemotaxis
FZC33_RS07895	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FZC33_RS07900	COG0392	lysyltransferase activity
FZC33_RS07905	COG3781	membrane
FZC33_RS07910	COG0346	lactoylglutathione lyase activity
FZC33_RS07925	COG2133	pyrroloquinoline quinone binding
FZC33_RS07945	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FZC33_RS07955	COG0803	Belongs to the bacterial solute-binding protein 9 family
FZC33_RS07960	COG1121	(ABC) transporter
FZC33_RS07970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FZC33_RS07980	COG0697	spore germination
FZC33_RS07995	COG4106	trans-aconitate 2-methyltransferase activity
FZC33_RS08015	COG3964	amidohydrolase
FZC33_RS08020	COG0318	PFAM AMP-dependent synthetase and ligase
FZC33_RS08035	COG1177	transmembrane transport
FZC33_RS08040	COG1176	ABC-type spermidine putrescine transport system, permease component I
FZC33_RS08045	COG3842	ATPase activity
FZC33_RS08055	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FZC33_RS08080	COG0583	DNA-binding transcription factor activity
FZC33_RS08115	COG4264	IucA IucC family
FZC33_RS08135	COG2936	dipeptidyl-peptidase activity
FZC33_RS08155	COG2205	protein histidine kinase activity
FZC33_RS08160	COG0745	RESPONSE REGULATOR receiver
FZC33_RS08185	COG2835	tetraacyldisaccharide 4'-kinase activity
FZC33_RS08190	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FZC33_RS08235	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FZC33_RS08240	COG0482	sulfurtransferase activity
FZC33_RS08265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FZC33_RS08270	COG0477	Major facilitator Superfamily
FZC33_RS08290	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FZC33_RS08310	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FZC33_RS08320	COG1278	Cold shock
FZC33_RS08350	COG1278	Cold shock
FZC33_RS08370	COG0842	Transport permease protein
FZC33_RS08375	COG1131	(ABC) transporter
FZC33_RS08385	COG3842	ATPase activity
FZC33_RS08395	COG1175	transmembrane transport
FZC33_RS08400	COG0395	ABC-type sugar transport system, permease component
FZC33_RS08410	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FZC33_RS08415	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FZC33_RS08420	COG0519	Catalyzes the synthesis of GMP from XMP
FZC33_RS08420	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FZC33_RS08430	COG0246	Mannitol dehydrogenase
FZC33_RS08440	COG1846	Transcriptional regulator
FZC33_RS08470	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS08485	COG1737	Transcriptional regulator
FZC33_RS08490	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FZC33_RS08495	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FZC33_RS08505	COG0800	Aldolase
FZC33_RS08510	COG1070	Carbohydrate kinase
FZC33_RS08515	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS08545	COG4566	intracellular signal transduction
FZC33_RS08590	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS08620	COG1605	Chorismate mutase
FZC33_RS08625	COG0154	amidase activity
FZC33_RS08635	COG1177	transmembrane transport
FZC33_RS08645	COG3842	ATPase activity
FZC33_RS08655	COG1012	belongs to the aldehyde dehydrogenase family
FZC33_RS08685	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FZC33_RS08690	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FZC33_RS08695	COG0045	succinate-CoA ligase (ADP-forming) activity
FZC33_RS08700	COG2301	Belongs to the HpcH HpaI aldolase family
FZC33_RS08715	COG2197	response regulator
FZC33_RS08740	COG1192	Involved in chromosome partitioning
FZC33_RS08745	COG1475	DNA binding
FZC33_RS08750	COG1414	Transcriptional regulator
FZC33_RS08770	COG0583	DNA-binding transcription factor activity
FZC33_RS08790	COG2368	4-hydroxyphenylacetate
FZC33_RS08825	COG0604	alcohol dehydrogenase
FZC33_RS08835	COG4608	Belongs to the ABC transporter superfamily
FZC33_RS08840	COG0444	Belongs to the ABC transporter superfamily
FZC33_RS08850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FZC33_RS08860	COG2267	carboxylic ester hydrolase activity
FZC33_RS08865	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FZC33_RS08870	COG0583	DNA-binding transcription factor activity
FZC33_RS08880	COG0196	riboflavin kinase activity
FZC33_RS08895	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS08905	COG3833	ABC-type maltose transport systems, permease component
FZC33_RS08915	COG1253	flavin adenine dinucleotide binding
FZC33_RS08930	COG1063	alcohol dehydrogenase
FZC33_RS08940	COG1177	transmembrane transport
FZC33_RS08955	COG3842	ATPase activity
FZC33_RS08960	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS08970	COG4608	Belongs to the ABC transporter superfamily
FZC33_RS08975	COG0444	Belongs to the ABC transporter superfamily
FZC33_RS08980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FZC33_RS08985	COG0601	transmembrane transport
FZC33_RS08995	COG0459	protein refolding
FZC33_RS09000	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FZC33_RS09030	COG0747	negative chemotaxis
FZC33_RS09035	COG4172	Belongs to the ABC transporter superfamily
FZC33_RS09040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FZC33_RS09050	COG1879	ABC-type sugar transport system periplasmic component
FZC33_RS09055	COG1129	ABC transporter
FZC33_RS09060	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS09065	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS09070	COG0494	nUDIX hydrolase
FZC33_RS09075	COG0583	DNA-binding transcription factor activity
FZC33_RS09110	COG0697	spore germination
FZC33_RS09125	COG0326	Molecular chaperone. Has ATPase activity
FZC33_RS09145	COG1672	PFAM Archaeal ATPase
FZC33_RS09145	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
FZC33_RS09150	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FZC33_RS09180	COG2072	flavoprotein involved in K transport
FZC33_RS09205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FZC33_RS09260	COG0535	radical SAM domain protein
FZC33_RS09265	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
FZC33_RS09270	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
FZC33_RS09275	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FZC33_RS09285	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FZC33_RS09290	COG0745	RESPONSE REGULATOR receiver
FZC33_RS09295	COG5002	protein histidine kinase activity
FZC33_RS09305	COG2218	PFAM glutamate synthase alpha subunit domain protein
FZC33_RS09310	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
FZC33_RS09315	COG1229	Formylmethanofuran dehydrogenase subunit A
FZC33_RS09320	COG1029	Formylmethanofuran dehydrogenase, subunit B
FZC33_RS09330	COG0702	epimerase
FZC33_RS09340	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
FZC33_RS09345	COG1181	Belongs to the D-alanine--D-alanine ligase family
FZC33_RS09355	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
FZC33_RS09415	COG1131	(ABC) transporter
FZC33_RS09450	COG1921	L-seryl-tRNASec selenium transferase activity
FZC33_RS09465	COG0444	Belongs to the ABC transporter superfamily
FZC33_RS09470	COG3964	amidohydrolase
FZC33_RS09480	COG0601	transmembrane transport
FZC33_RS09505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FZC33_RS09510	COG0626	cystathionine gamma-synthase activity
FZC33_RS09515	COG0395	ABC-type sugar transport system, permease component
FZC33_RS09520	COG1175	transmembrane transport
FZC33_RS09540	COG1132	(ABC) transporter
FZC33_RS09550	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FZC33_RS09555	COG4774	siderophore transport
FZC33_RS09565	COG0848	biopolymer transport protein
FZC33_RS09575	COG1120	ATPase activity
FZC33_RS09580	COG0010	Belongs to the arginase family
FZC33_RS09625	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FZC33_RS09635	COG5265	(ABC) transporter
FZC33_RS09645	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FZC33_RS09655	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FZC33_RS09660	COG1309	transcriptional regulator
FZC33_RS09665	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS09705	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FZC33_RS09720	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FZC33_RS09740	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FZC33_RS09745	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FZC33_RS09760	COG2211	Major facilitator Superfamily
FZC33_RS09785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FZC33_RS09790	COG1686	Belongs to the peptidase S11 family
FZC33_RS09795	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FZC33_RS09805	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FZC33_RS09810	COG0084	hydrolase, TatD family'
FZC33_RS09820	COG1283	sodium-dependent phosphate transmembrane transporter activity
FZC33_RS09830	COG1522	sequence-specific DNA binding
FZC33_RS09855	COG0174	glutamine synthetase
FZC33_RS09865	COG1535	isochorismatase
FZC33_RS09865	COG3433	isochorismatase activity
FZC33_RS09900	COG1652	LysM domain
FZC33_RS09910	COG3833	ABC-type maltose transport systems, permease component
FZC33_RS09915	COG1175	transmembrane transport
FZC33_RS09930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FZC33_RS09975	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
FZC33_RS10000	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FZC33_RS10005	COG1862	Preprotein translocase
FZC33_RS10025	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FZC33_RS10030	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FZC33_RS10040	COG0805	protein transport
FZC33_RS10045	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FZC33_RS10050	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FZC33_RS10055	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FZC33_RS10060	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FZC33_RS10065	COG1472	Belongs to the glycosyl hydrolase 3 family
FZC33_RS10075	COG0018	arginyl-trna synthetase
FZC33_RS10080	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FZC33_RS10090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FZC33_RS10100	COG0316	Belongs to the HesB IscA family
FZC33_RS10125	COG3119	arylsulfatase activity
FZC33_RS10135	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FZC33_RS10145	COG2186	Transcriptional regulator
FZC33_RS10150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FZC33_RS10155	COG0765	amino acid transport
FZC33_RS10165	COG0525	valine-tRNA ligase activity
FZC33_RS10170	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
FZC33_RS10175	COG2943	transferase activity, transferring hexosyl groups
FZC33_RS10195	COG0730	response to heat
FZC33_RS10200	COG2204	response regulator
FZC33_RS10205	COG5000	phosphorelay sensor kinase activity
FZC33_RS10220	COG2204	response regulator
FZC33_RS10245	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FZC33_RS10255	COG0154	amidase activity
FZC33_RS10265	COG4249	Peptidase C14 caspase catalytic subunit p20
FZC33_RS10265	COG2319	Wd-40 repeat
FZC33_RS10275	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FZC33_RS10285	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
FZC33_RS10295	COG0488	(ABC) transporter
FZC33_RS10300	COG0540	Belongs to the ATCase OTCase family
FZC33_RS10305	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FZC33_RS10320	COG0758	DNA mediated transformation
FZC33_RS10325	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FZC33_RS10325	COG1754	DNA topoisomerase type I activity
FZC33_RS10345	COG0557	exoribonuclease II activity
FZC33_RS10360	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FZC33_RS10365	COG0477	Major facilitator Superfamily
FZC33_RS10380	COG4451	ribulose bisphosphate carboxylase, small
FZC33_RS10385	COG1850	ribulose-bisphosphate carboxylase activity
FZC33_RS10415	COG0784	Response regulator, receiver
FZC33_RS10425	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FZC33_RS10435	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FZC33_RS10460	COG1278	Cold shock
FZC33_RS10465	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FZC33_RS10470	COG0346	lactoylglutathione lyase activity
FZC33_RS10490	COG0586	Pfam SNARE associated Golgi protein
FZC33_RS10510	COG1960	acyl-CoA dehydrogenase activity
FZC33_RS10525	COG1024	Enoyl-CoA hydratase
FZC33_RS10530	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FZC33_RS10540	COG0667	Aldo Keto reductase
FZC33_RS10545	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FZC33_RS10550	COG3158	transport of potassium into the cell
FZC33_RS10565	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FZC33_RS10585	COG3153	acetyltransferase
FZC33_RS10590	COG3811	Belongs to the UPF0386 family
FZC33_RS10630	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FZC33_RS10635	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FZC33_RS10640	COG0740	serine-type endopeptidase activity
FZC33_RS10645	COG0544	peptidyl-prolyl cis-trans isomerase activity
FZC33_RS10655	COG2132	Multicopper oxidase
FZC33_RS10670	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FZC33_RS10670	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FZC33_RS10675	COG0347	Belongs to the P(II) protein family
FZC33_RS10680	COG0174	glutamine synthetase
FZC33_RS10685	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
FZC33_RS10690	COG2986	histidine ammonia-lyase
FZC33_RS10695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FZC33_RS10750	COG0714	Associated with various cellular activities
FZC33_RS10770	COG2135	peptidase activity
FZC33_RS10785	COG0242	peptide deformylase activity
FZC33_RS10790	COG5507	3-demethylubiquinone-9 3-methyltransferase
FZC33_RS10795	COG1393	Belongs to the ArsC family
FZC33_RS10805	COG3842	ATPase activity
FZC33_RS10810	COG0395	ABC-type sugar transport system, permease component
FZC33_RS10825	COG0626	cystathionine gamma-synthase activity
FZC33_RS10835	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FZC33_RS10845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FZC33_RS10850	COG0765	amino acid transport
FZC33_RS10855	COG0765	amino acid transport
FZC33_RS10860	COG1126	abc transporter atp-binding protein
FZC33_RS10865	COG5006	permease, DMT superfamily
FZC33_RS10880	COG1079	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS10885	COG4603	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS10890	COG3845	ABC transporter
FZC33_RS10905	COG0717	Belongs to the dCTP deaminase family
FZC33_RS10925	COG0477	Major facilitator Superfamily
FZC33_RS10935	COG2186	Transcriptional regulator
FZC33_RS10945	COG3842	ATPase activity
FZC33_RS10970	COG0149	triose-phosphate isomerase activity
FZC33_RS10980	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FZC33_RS10995	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FZC33_RS11000	COG0134	indole-3-glycerol-phosphate synthase activity
FZC33_RS11005	COG0315	cyclic pyranopterin monophosphate synthase activity
FZC33_RS11010	COG0303	'Molybdopterin
FZC33_RS11015	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FZC33_RS11025	COG3585	molybdate ion transport
FZC33_RS11030	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
FZC33_RS11040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FZC33_RS11050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FZC33_RS11055	COG0372	Belongs to the citrate synthase family
FZC33_RS11060	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FZC33_RS11065	COG3494	Protein of unknown function (DUF1009)
FZC33_RS11075	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FZC33_RS11080	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FZC33_RS11085	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FZC33_RS11090	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FZC33_RS11095	COG0750	zinc metalloprotease
FZC33_RS11105	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FZC33_RS11110	COG0233	cytoplasmic translational termination
FZC33_RS11115	COG0528	UMP kinase activity
FZC33_RS11120	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FZC33_RS11125	COG0052	Belongs to the universal ribosomal protein uS2 family
FZC33_RS11135	COG1136	(ABC) transporter
FZC33_RS11140	COG4591	ABC-type transport system involved in lipoprotein release permease component
FZC33_RS11145	COG0442	prolyl-tRNA aminoacylation
FZC33_RS11150	COG1648	precorrin-2 dehydrogenase activity
FZC33_RS11150	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FZC33_RS11385	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FZC33_RS11435	COG3750	Belongs to the UPF0335 family
FZC33_RS11500	COG1278	Cold shock
FZC33_RS11535	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FZC33_RS11540	COG0511	ligase activity, forming carbon-carbon bonds
FZC33_RS11545	COG0439	Biotin carboxylase
FZC33_RS11550	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FZC33_RS11560	COG4765	Protein conserved in bacteria
FZC33_RS11570	COG1957	nucleoside hydrolase
FZC33_RS11580	COG1252	NADH dehydrogenase
FZC33_RS11585	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FZC33_RS11590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FZC33_RS11595	COG0625	glutathione transferase activity
FZC33_RS11605	COG2076	Multidrug Resistance protein
FZC33_RS11615	COG2226	methyltransferase
FZC33_RS11625	COG1522	sequence-specific DNA binding
FZC33_RS11635	COG3457	Alanine racemase
FZC33_RS11640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FZC33_RS11650	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FZC33_RS11655	COG1012	belongs to the aldehyde dehydrogenase family
FZC33_RS11675	COG0531	amino acid
FZC33_RS11680	COG1522	sequence-specific DNA binding
FZC33_RS11690	COG0656	L-ascorbic acid biosynthetic process
FZC33_RS11710	COG0438	transferase activity, transferring glycosyl groups
FZC33_RS11725	COG0489	protein tyrosine kinase activity
FZC33_RS11725	COG3206	protein involved in exopolysaccharide biosynthesis
FZC33_RS11730	COG2197	response regulator
FZC33_RS11750	COG2197	response regulator
FZC33_RS11755	COG2199	diguanylate cyclase activity
FZC33_RS11755	COG2202	Pas domain
FZC33_RS11755	COG2200	EAL domain
FZC33_RS11780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FZC33_RS11790	COG3916	Acyl-homoserine-lactone synthase
FZC33_RS11800	COG2197	response regulator
FZC33_RS11805	COG0646	methionine synthase
FZC33_RS11805	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FZC33_RS11815	COG1566	PFAM secretion protein HlyD family protein
FZC33_RS11825	COG1289	transmembrane transporter activity
FZC33_RS11850	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FZC33_RS11855	COG0145	ligase activity
FZC33_RS11860	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
FZC33_RS11865	COG4647	ligase activity
FZC33_RS11870	COG3119	arylsulfatase activity
FZC33_RS11875	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS11895	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
FZC33_RS11900	COG1609	Transcriptional regulator
FZC33_RS11910	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS11915	COG1129	ABC transporter
FZC33_RS11935	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FZC33_RS11945	COG0477	Major facilitator Superfamily
FZC33_RS11950	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
FZC33_RS11980	COG1683	Conserved Protein
FZC33_RS11985	COG0148	phosphopyruvate hydratase activity
FZC33_RS12020	COG1349	DNA-binding transcription factor activity
FZC33_RS12025	COG0583	DNA-binding transcription factor activity
FZC33_RS12050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FZC33_RS12055	COG0154	amidase activity
FZC33_RS12060	COG0415	Belongs to the DNA photolyase family
FZC33_RS12065	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FZC33_RS12085	COG3385	transposase activity
FZC33_RS12090	COG2721	sulfolactate sulfo-lyase activity
FZC33_RS12095	COG2186	Transcriptional regulator
FZC33_RS12105	COG0697	spore germination
FZC33_RS12110	COG0778	Nitroreductase
FZC33_RS12115	COG0583	DNA-binding transcription factor activity
FZC33_RS12125	COG1335	isochorismatase
FZC33_RS12140	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FZC33_RS12145	COG0175	sulfate reduction
FZC33_RS12160	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FZC33_RS12165	COG0583	DNA-binding transcription factor activity
FZC33_RS12180	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FZC33_RS12185	COG0243	molybdopterin cofactor binding
FZC33_RS12205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FZC33_RS12215	COG0583	DNA-binding transcription factor activity
FZC33_RS12235	COG0318	PFAM AMP-dependent synthetase and ligase
FZC33_RS12250	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FZC33_RS12255	COG1802	Transcriptional regulator
FZC33_RS12265	COG2186	Transcriptional regulator
FZC33_RS12270	COG0483	inositol monophosphate 1-phosphatase activity
FZC33_RS12300	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FZC33_RS12305	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FZC33_RS12310	COG0010	Belongs to the arginase family
FZC33_RS12325	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FZC33_RS12335	COG1609	Transcriptional regulator
FZC33_RS12340	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FZC33_RS12345	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FZC33_RS12350	COG0778	Nitroreductase
FZC33_RS12355	COG2814	Major facilitator Superfamily
FZC33_RS12370	COG1376	ErfK ybiS ycfS ynhG family protein
FZC33_RS12380	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FZC33_RS12390	COG0477	Major facilitator Superfamily
FZC33_RS12400	COG0640	Transcriptional regulator
FZC33_RS12405	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FZC33_RS12410	COG1012	belongs to the aldehyde dehydrogenase family
FZC33_RS12415	COG0302	gtp cyclohydrolase
FZC33_RS12430	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FZC33_RS12435	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FZC33_RS12470	COG1760	l-serine dehydratase
FZC33_RS12480	COG0416	fatty acid biosynthetic process
FZC33_RS12485	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FZC33_RS12490	COG0776	regulation of translation
FZC33_RS12505	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FZC33_RS12510	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
FZC33_RS12515	COG2080	2 iron, 2 sulfur cluster binding
FZC33_RS12525	COG0243	molybdopterin cofactor binding
FZC33_RS12535	COG0583	DNA-binding transcription factor activity
FZC33_RS12540	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
FZC33_RS12555	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FZC33_RS12560	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FZC33_RS12565	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FZC33_RS12575	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FZC33_RS12575	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FZC33_RS12580	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FZC33_RS12585	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FZC33_RS12600	COG0113	porphobilinogen synthase activity
FZC33_RS12610	COG0559	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS12615	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FZC33_RS12625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FZC33_RS12635	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FZC33_RS12645	COG0673	inositol 2-dehydrogenase activity
FZC33_RS12655	COG0673	inositol 2-dehydrogenase activity
FZC33_RS12660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FZC33_RS12665	COG3962	Belongs to the TPP enzyme family
FZC33_RS12675	COG3718	enzyme involved in inositol metabolism
FZC33_RS12695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FZC33_RS12700	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FZC33_RS12705	COG0384	phenazine biosynthesis protein PhzF
FZC33_RS12720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FZC33_RS12730	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS12735	COG1129	ABC transporter
FZC33_RS12750	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FZC33_RS12755	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FZC33_RS12760	COG5425	PFAM Usg family protein
FZC33_RS12770	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FZC33_RS12775	COG0440	acetolactate synthase activity
FZC33_RS12780	COG0028	Belongs to the TPP enzyme family
FZC33_RS12795	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FZC33_RS12805	COG0560	Phosphoserine phosphatase
FZC33_RS12810	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FZC33_RS12815	COG0330	HflC and HflK could
FZC33_RS12820	COG0330	HflC and HflK could
FZC33_RS12845	COG0114	fumarate hydratase activity
FZC33_RS12865	COG0277	FAD linked oxidase domain protein
FZC33_RS12875	COG3739	integral membrane protein
FZC33_RS12880	COG2113	Glycine betaine
FZC33_RS12885	COG4175	Glycine betaine
FZC33_RS12885	COG3448	diguanylate cyclase activity
FZC33_RS12890	COG4176	ABC-type proline glycine betaine transport system permease component
FZC33_RS12905	COG0210	DNA helicase
FZC33_RS12910	COG1823	symporter activity
FZC33_RS12915	COG2124	cytochrome p450
FZC33_RS12920	COG0436	Aminotransferase
FZC33_RS12925	COG2264	protein methyltransferase activity
FZC33_RS12930	COG0006	proline dipeptidase activity
FZC33_RS12930	COG0006	proline dipeptidase activity
FZC33_RS12955	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FZC33_RS12960	COG0497	DNA recombination
FZC33_RS12965	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FZC33_RS12975	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FZC33_RS12980	COG0849	cell division
FZC33_RS12985	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FZC33_RS12990	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FZC33_RS13010	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FZC33_RS13015	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FZC33_RS13025	COG1309	transcriptional regulator
FZC33_RS13035	COG1942	4-Oxalocrotonate Tautomerase
FZC33_RS13040	COG0583	DNA-binding transcription factor activity
FZC33_RS13050	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FZC33_RS13055	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FZC33_RS13070	COG0275	rRNA processing
FZC33_RS13090	COG2197	response regulator
FZC33_RS13110	COG3023	N-Acetylmuramoyl-L-alanine amidase
FZC33_RS13125	COG1247	-acetyltransferase
FZC33_RS13130	COG2746	aminoglycoside 3-N-acetyltransferase activity
FZC33_RS13145	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FZC33_RS13160	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FZC33_RS13170	COG4106	trans-aconitate 2-methyltransferase activity
FZC33_RS13180	COG0443	Heat shock 70 kDa protein
FZC33_RS13185	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FZC33_RS13195	COG1994	Peptidase M50
FZC33_RS13215	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS13230	COG0672	)-iron permease
FZC33_RS13235	COG2822	iron ion transport
FZC33_RS13255	COG1070	Carbohydrate kinase
FZC33_RS13270	COG0745	RESPONSE REGULATOR receiver
FZC33_RS13290	COG1054	Belongs to the UPF0176 family
FZC33_RS13300	COG0189	ligase activity
FZC33_RS13305	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
FZC33_RS13305	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
FZC33_RS13310	COG0477	Major facilitator Superfamily
FZC33_RS13355	COG4214	carbohydrate transport
FZC33_RS13385	COG0477	Major facilitator Superfamily
FZC33_RS13390	COG0583	DNA-binding transcription factor activity
FZC33_RS13395	COG1522	sequence-specific DNA binding
FZC33_RS13405	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FZC33_RS13410	COG1012	belongs to the aldehyde dehydrogenase family
FZC33_RS13425	COG0765	amino acid transport
FZC33_RS13430	COG0765	amino acid transport
FZC33_RS13435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FZC33_RS13455	COG1215	transferase activity, transferring glycosyl groups
FZC33_RS13460	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FZC33_RS13470	COG0640	Transcriptional regulator
FZC33_RS13480	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS13490	COG4166	transmembrane transport
FZC33_RS13500	COG0446	pyridine nucleotide-disulphide oxidoreductase
FZC33_RS13500	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FZC33_RS13510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FZC33_RS13525	COG0583	DNA-binding transcription factor activity
FZC33_RS13530	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS13550	COG0395	ABC-type sugar transport system, permease component
FZC33_RS13555	COG1082	Xylose isomerase domain protein TIM barrel
FZC33_RS13560	COG3842	ATPase activity
FZC33_RS13580	COG1388	LysM domain
FZC33_RS13580	COG1376	ErfK ybiS ycfS ynhG family protein
FZC33_RS13585	COG0583	DNA-binding transcription factor activity
FZC33_RS13590	COG3795	YCII-related domain
FZC33_RS13595	COG4941	Belongs to the sigma-70 factor family
FZC33_RS13605	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS13610	COG0583	DNA-binding transcription factor activity
FZC33_RS13635	COG1309	transcriptional regulator
FZC33_RS13650	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FZC33_RS13655	COG1802	Transcriptional regulator
FZC33_RS13660	COG1129	ABC transporter
FZC33_RS13665	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS13675	COG2076	Multidrug Resistance protein
FZC33_RS13690	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FZC33_RS13710	COG0747	negative chemotaxis
FZC33_RS13715	COG0387	Pfam Sodium calcium exchanger
FZC33_RS13725	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS13750	COG0583	DNA-binding transcription factor activity
FZC33_RS13755	COG0492	ferredoxin-NADP+ reductase activity
FZC33_RS13765	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FZC33_RS13785	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS13815	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FZC33_RS13820	COG1054	Belongs to the UPF0176 family
FZC33_RS13825	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FZC33_RS13845	COG0556	nucleotide-excision repair
FZC33_RS13895	COG2814	Major facilitator Superfamily
FZC33_RS13905	COG0243	molybdopterin cofactor binding
FZC33_RS13920	COG0123	including yeast histone deacetylase and acetoin utilization protein
FZC33_RS13935	COG2124	cytochrome p450
FZC33_RS13940	COG1309	transcriptional regulator
FZC33_RS13945	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FZC33_RS13985	COG0346	lactoylglutathione lyase activity
FZC33_RS13990	COG3842	ATPase activity
FZC33_RS13995	COG0395	ABC-type sugar transport system, permease component
FZC33_RS14000	COG1175	transmembrane transport
FZC33_RS14005	COG1653	transport
FZC33_RS14010	COG0205	6-phosphofructokinase activity
FZC33_RS14025	COG2223	nitrite transmembrane transporter activity
FZC33_RS14030	COG0534	Mate efflux family protein
FZC33_RS14040	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FZC33_RS14060	COG0314	molybdopterin synthase activity
FZC33_RS14070	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FZC33_RS14075	COG0322	excinuclease ABC activity
FZC33_RS14080	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS14105	COG0625	glutathione transferase activity
FZC33_RS14110	COG1278	Cold shock
FZC33_RS14115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FZC33_RS14130	COG0484	heat shock protein binding
FZC33_RS14135	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FZC33_RS14150	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FZC33_RS14155	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS14160	COG0259	pyridoxamine-phosphate oxidase activity
FZC33_RS14180	COG2197	response regulator
FZC33_RS14220	COG0534	Mate efflux family protein
FZC33_RS14225	COG0657	acetylesterase activity
FZC33_RS14240	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
FZC33_RS14245	COG1733	regulation of RNA biosynthetic process
FZC33_RS14250	COG0604	alcohol dehydrogenase
FZC33_RS14275	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FZC33_RS14275	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FZC33_RS14280	COG1522	sequence-specific DNA binding
FZC33_RS14285	COG0686	Belongs to the AlaDH PNT family
FZC33_RS14295	COG0009	L-threonylcarbamoyladenylate synthase
FZC33_RS14300	COG1960	acyl-CoA dehydrogenase activity
FZC33_RS14305	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS14310	COG0123	including yeast histone deacetylase and acetoin utilization protein
FZC33_RS14335	COG2135	peptidase activity
FZC33_RS14345	COG1686	Belongs to the peptidase S11 family
FZC33_RS14355	COG2249	NAD(P)H dehydrogenase (quinone) activity
FZC33_RS14365	COG3265	gluconokinase activity
FZC33_RS14370	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FZC33_RS14375	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
FZC33_RS14380	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FZC33_RS14385	COG1722	exodeoxyribonuclease VII activity
FZC33_RS14395	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FZC33_RS14400	COG0354	folic acid binding
FZC33_RS14410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FZC33_RS14415	COG0519	Catalyzes the synthesis of GMP from XMP
FZC33_RS14420	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
FZC33_RS14445	COG1573	uracil-dna glycosylase
FZC33_RS14450	COG2321	neutral zinc metallopeptidase
FZC33_RS14455	COG0673	inositol 2-dehydrogenase activity
FZC33_RS14460	COG1802	Transcriptional regulator
FZC33_RS14475	COG1175	transmembrane transport
FZC33_RS14480	COG0395	ABC-type sugar transport system, permease component
FZC33_RS14490	COG0673	inositol 2-dehydrogenase activity
FZC33_RS14495	COG3842	ATPase activity
FZC33_RS14515	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FZC33_RS14525	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS14530	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS14535	COG1129	ABC transporter
FZC33_RS14545	COG2189	Belongs to the N(4) N(6)-methyltransferase family
FZC33_RS14555	COG0673	inositol 2-dehydrogenase activity
FZC33_RS14570	COG1116	anion transmembrane transporter activity
FZC33_RS14575	COG1737	Transcriptional regulator
FZC33_RS14600	COG2271	Major facilitator Superfamily
FZC33_RS14610	COG1194	a g-specific adenine glycosylase
FZC33_RS14625	COG1196	nuclear chromosome segregation
FZC33_RS14630	COG0640	Transcriptional regulator
FZC33_RS14650	COG0356	it plays a direct role in the translocation of protons across the membrane
FZC33_RS14660	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FZC33_RS14665	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FZC33_RS14675	COG2304	oxidoreductase activity
FZC33_RS14685	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FZC33_RS14695	COG1396	sequence-specific DNA binding
FZC33_RS14695	COG1917	Cupin 2, conserved barrel domain protein
FZC33_RS14700	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FZC33_RS14710	COG3842	ATPase activity
FZC33_RS14715	COG1176	ABC-type spermidine putrescine transport system, permease component I
FZC33_RS14735	COG2814	Major facilitator Superfamily
FZC33_RS14745	COG1846	Transcriptional regulator
FZC33_RS14755	COG0142	geranyltranstransferase activity
FZC33_RS14775	COG3842	ATPase activity
FZC33_RS14790	COG1177	transmembrane transport
FZC33_RS14795	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS14800	COG1301	dicarboxylic acid transport
FZC33_RS14825	COG0752	glycyl-tRNA synthetase alpha subunit
FZC33_RS14830	COG0751	glycine-tRNA ligase activity
FZC33_RS14835	COG0583	DNA-binding transcription factor activity
FZC33_RS14840	COG2814	Major facilitator Superfamily
FZC33_RS14850	COG0604	alcohol dehydrogenase
FZC33_RS14855	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FZC33_RS14855	COG0574	Belongs to the PEP-utilizing enzyme family
FZC33_RS14865	COG1404	Belongs to the peptidase S8 family
FZC33_RS14870	COG1704	LemA family
FZC33_RS14875	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
FZC33_RS14890	COG0395	ABC-type sugar transport system, permease component
FZC33_RS14925	COG1522	sequence-specific DNA binding
FZC33_RS14945	COG3214	Protein conserved in bacteria
FZC33_RS14950	COG1063	alcohol dehydrogenase
FZC33_RS14955	COG1570	exodeoxyribonuclease VII activity
FZC33_RS14965	COG1663	tetraacyldisaccharide 4'-kinase activity
FZC33_RS14970	COG1519	Transferase
FZC33_RS14985	COG0483	inositol monophosphate 1-phosphatase activity
FZC33_RS15005	COG2329	Antibiotic biosynthesis monooxygenase
FZC33_RS15030	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FZC33_RS15035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FZC33_RS15040	COG4558	Periplasmic binding protein
FZC33_RS15045	COG4771	TonB-dependent receptor
FZC33_RS15065	COG0583	DNA-binding transcription factor activity
FZC33_RS15070	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FZC33_RS15100	COG1846	Transcriptional regulator
FZC33_RS15100	COG1940	carbohydrate kinase activity
FZC33_RS15115	COG1902	pentaerythritol trinitrate reductase activity
FZC33_RS15135	COG0662	Cupin 2, conserved barrel domain protein
FZC33_RS15140	COG0583	DNA-binding transcription factor activity
FZC33_RS15160	COG1960	acyl-CoA dehydrogenase activity
FZC33_RS15170	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FZC33_RS15175	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FZC33_RS15180	COG0109	protoheme IX farnesyltransferase activity
FZC33_RS15190	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
FZC33_RS15215	COG0612	Peptidase, M16
FZC33_RS15220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FZC33_RS15235	COG0662	Cupin 2, conserved barrel domain protein
FZC33_RS15240	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FZC33_RS15255	COG1678	Uncharacterized ACR, COG1678
FZC33_RS15265	COG0678	peroxiredoxin activity
FZC33_RS15270	COG0328	RNA-DNA hybrid ribonuclease activity
FZC33_RS15275	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FZC33_RS15280	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FZC33_RS15285	COG4566	intracellular signal transduction
FZC33_RS15290	COG4191	Histidine kinase
FZC33_RS15300	COG1116	anion transmembrane transporter activity
FZC33_RS15325	COG1069	ribulokinase activity
FZC33_RS15335	COG1733	regulation of RNA biosynthetic process
FZC33_RS15345	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FZC33_RS15380	COG0010	Belongs to the arginase family
FZC33_RS15395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FZC33_RS15410	COG1309	transcriptional regulator
FZC33_RS15415	COG0583	DNA-binding transcription factor activity
FZC33_RS15420	COG0667	Aldo Keto reductase
FZC33_RS15425	COG2223	nitrite transmembrane transporter activity
FZC33_RS15430	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS15445	COG0484	heat shock protein binding
FZC33_RS15450	COG0667	Aldo Keto reductase
FZC33_RS15460	COG0583	DNA-binding transcription factor activity
FZC33_RS15485	COG2132	Multicopper oxidase
FZC33_RS15520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FZC33_RS15525	COG0174	glutamine synthetase
FZC33_RS15535	COG3706	GGDEF domain
FZC33_RS15550	COG1113	amino acid transport
FZC33_RS15565	COG2807	transmembrane transport
FZC33_RS15570	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FZC33_RS15585	COG0765	amino acid transport
FZC33_RS15590	COG2723	6-phospho-beta-galactosidase activity
FZC33_RS15645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FZC33_RS15650	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FZC33_RS15655	COG0438	transferase activity, transferring glycosyl groups
FZC33_RS15670	COG0438	transferase activity, transferring glycosyl groups
FZC33_RS15675	COG1560	Kdo2-lipid A biosynthetic process
FZC33_RS15675	COG4783	chaperone-mediated protein folding
FZC33_RS15705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FZC33_RS15715	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FZC33_RS15720	COG3755	Protein conserved in bacteria
FZC33_RS15725	COG3960	tartronate-semialdehyde synthase activity
FZC33_RS15730	COG3622	Belongs to the hyi family
FZC33_RS15735	COG2084	Dehydrogenase
FZC33_RS15740	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FZC33_RS15750	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FZC33_RS15765	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FZC33_RS15770	COG0045	succinate-CoA ligase (ADP-forming) activity
FZC33_RS15775	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FZC33_RS15800	COG0045	succinate-CoA ligase (ADP-forming) activity
FZC33_RS15805	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FZC33_RS15810	COG1802	Transcriptional regulator
FZC33_RS15970	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FZC33_RS16040	COG0483	inositol monophosphate 1-phosphatase activity
FZC33_RS16065	COG0126	phosphoglycerate kinase activity
FZC33_RS16070	COG0583	DNA-binding transcription factor activity
FZC33_RS16075	COG0702	epimerase
FZC33_RS16135	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FZC33_RS16140	COG1692	metallophosphoesterase
FZC33_RS16145	COG0217	transcriptional regulatory protein
FZC33_RS16150	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FZC33_RS16155	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FZC33_RS16160	COG0632	four-way junction helicase activity
FZC33_RS16165	COG2255	four-way junction helicase activity
FZC33_RS16170	COG2885	chlorophyll binding
FZC33_RS16175	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FZC33_RS16180	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FZC33_RS16185	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FZC33_RS16190	COG4208	sulfate ABC transporter
FZC33_RS16195	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FZC33_RS16205	COG0823	Involved in the tonB-independent uptake of proteins
FZC33_RS16215	COG0848	biopolymer transport protein
FZC33_RS16225	COG0824	Thioesterase
FZC33_RS16235	COG0037	tRNA processing
FZC33_RS16240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FZC33_RS16260	COG1132	(ABC) transporter
FZC33_RS16265	COG2239	Acts as a magnesium transporter
FZC33_RS16270	COG0254	rRNA binding
FZC33_RS16280	COG1309	transcriptional regulator
FZC33_RS16335	COG3842	ATPase activity
FZC33_RS16355	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FZC33_RS16365	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FZC33_RS16370	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FZC33_RS16385	COG0564	pseudouridine synthase activity
FZC33_RS16405	COG2094	Belongs to the DNA glycosylase MPG family
FZC33_RS16410	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
FZC33_RS16425	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FZC33_RS16430	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FZC33_RS16460	COG2814	Major facilitator Superfamily
FZC33_RS16470	COG0765	amino acid transport
FZC33_RS16475	COG0765	amino acid transport
FZC33_RS16485	COG3842	ATPase activity
FZC33_RS16490	COG4149	molybdate abc transporter
FZC33_RS16495	COG4149	molybdate abc transporter
FZC33_RS16505	COG0583	DNA-binding transcription factor activity
FZC33_RS16530	COG0402	S-adenosylhomocysteine deaminase activity
FZC33_RS16545	COG2249	NAD(P)H dehydrogenase (quinone) activity
FZC33_RS16555	COG2140	Oxalate decarboxylase
FZC33_RS16565	COG1129	ABC transporter
FZC33_RS16570	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS16575	COG0371	Dehydrogenase
FZC33_RS16580	COG1063	alcohol dehydrogenase
FZC33_RS16590	COG2390	Transcriptional regulator
FZC33_RS16600	COG1012	belongs to the aldehyde dehydrogenase family
FZC33_RS16605	COG1132	(ABC) transporter
FZC33_RS16625	COG0583	DNA-binding transcription factor activity
FZC33_RS16630	COG0346	lactoylglutathione lyase activity
FZC33_RS16650	COG0400	carboxylic ester hydrolase activity
FZC33_RS16655	COG1741	Belongs to the pirin family
FZC33_RS16665	COG1175	transmembrane transport
FZC33_RS16680	COG1086	Polysaccharide biosynthesis protein
FZC33_RS16685	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FZC33_RS16690	COG2188	Transcriptional regulator
FZC33_RS16705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FZC33_RS16710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FZC33_RS16735	COG0174	glutamine synthetase
FZC33_RS16745	COG1846	Transcriptional regulator
FZC33_RS16750	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FZC33_RS16800	COG0129	dihydroxy-acid dehydratase activity
FZC33_RS16805	COG2755	lipolytic protein G-D-S-L family
FZC33_RS16805	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FZC33_RS16815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FZC33_RS16820	COG0392	lysyltransferase activity
FZC33_RS16820	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FZC33_RS16845	COG0737	Belongs to the 5'-nucleotidase family
FZC33_RS16870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FZC33_RS16875	COG1946	Acyl-CoA thioesterase
FZC33_RS16885	COG1872	DUF167
FZC33_RS16915	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FZC33_RS16940	COG3842	ATPase activity
FZC33_RS16945	COG0395	ABC-type sugar transport system, permease component
FZC33_RS16950	COG1175	transmembrane transport
FZC33_RS16960	COG1216	Glycosyl transferase, family 2
FZC33_RS16960	COG0438	transferase activity, transferring glycosyl groups
FZC33_RS17025	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FZC33_RS17030	COG1091	dTDP-4-dehydrorhamnose reductase activity
FZC33_RS17035	COG1088	dTDP-glucose 4,6-dehydratase activity
FZC33_RS17040	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
FZC33_RS17045	COG4974	Belongs to the 'phage' integrase family
FZC33_RS17050	COG0671	phosphoesterase, PA-phosphatase related
FZC33_RS17070	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FZC33_RS17075	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FZC33_RS17080	COG4536	flavin adenine dinucleotide binding
FZC33_RS17095	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FZC33_RS17100	COG4774	siderophore transport
FZC33_RS17105	COG3712	iron ion homeostasis
FZC33_RS17185	COG2852	Protein conserved in bacteria
FZC33_RS17190	COG3738	Protein conserved in bacteria
FZC33_RS17205	COG3038	cytochrome b561
FZC33_RS17230	COG0025	NhaP-type Na H and K H
FZC33_RS17235	COG3162	membrane
FZC33_RS17240	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FZC33_RS17245	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FZC33_RS17245	COG0446	pyridine nucleotide-disulphide oxidoreductase
FZC33_RS17255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FZC33_RS17265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FZC33_RS17335	COG1129	ABC transporter
FZC33_RS17340	COG1846	Transcriptional regulator
FZC33_RS17340	COG1940	carbohydrate kinase activity
FZC33_RS17355	COG2885	chlorophyll binding
FZC33_RS17365	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
FZC33_RS17370	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FZC33_RS17375	COG2890	protein-(glutamine-N5) methyltransferase activity
FZC33_RS17380	COG0583	DNA-binding transcription factor activity
FZC33_RS17385	COG2814	Major facilitator Superfamily
FZC33_RS17395	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FZC33_RS17400	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FZC33_RS17415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FZC33_RS17420	COG0601	transmembrane transport
FZC33_RS17425	COG0747	negative chemotaxis
FZC33_RS17430	COG0004	ammonium transporteR
FZC33_RS17435	COG0347	Belongs to the P(II) protein family
FZC33_RS17455	COG2986	histidine ammonia-lyase
FZC33_RS17460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FZC33_RS17490	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FZC33_RS17495	COG2205	protein histidine kinase activity
FZC33_RS17500	COG0745	RESPONSE REGULATOR receiver
FZC33_RS17535	COG0477	Major facilitator Superfamily
FZC33_RS17550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FZC33_RS17560	COG2233	PERMEase
FZC33_RS17590	COG4702	Belongs to the UPF0303 family
FZC33_RS17600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FZC33_RS17610	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FZC33_RS17615	COG1733	regulation of RNA biosynthetic process
FZC33_RS17620	COG2084	Dehydrogenase
FZC33_RS17630	COG4221	oxidoreductase activity
FZC33_RS17635	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS17645	COG0583	DNA-binding transcription factor activity
FZC33_RS17660	COG2354	Protein conserved in bacteria
FZC33_RS17695	COG0739	heme binding
FZC33_RS17705	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
FZC33_RS17715	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FZC33_RS17720	COG1845	cytochrome c oxidase, subunit III
FZC33_RS17725	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FZC33_RS17730	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FZC33_RS17735	COG0477	Major facilitator Superfamily
FZC33_RS17740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FZC33_RS17750	COG3842	ATPase activity
FZC33_RS17755	COG1176	ABC-type spermidine putrescine transport system, permease component I
FZC33_RS17760	COG1177	transmembrane transport
FZC33_RS17775	COG0542	response to heat
FZC33_RS17780	COG3038	cytochrome b561
FZC33_RS17785	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FZC33_RS17800	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
FZC33_RS17810	COG3588	fructose-bisphosphate aldolase
FZC33_RS17820	COG0174	glutamine synthetase
FZC33_RS17825	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FZC33_RS17855	COG5012	cobalamin binding
FZC33_RS17860	COG1376	ErfK ybiS ycfS ynhG family protein
FZC33_RS17860	COG1388	LysM domain
FZC33_RS17865	COG2814	Major facilitator Superfamily
FZC33_RS17895	COG1129	ABC transporter
FZC33_RS17900	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS17905	COG1879	ABC-type sugar transport system periplasmic component
FZC33_RS17915	COG0300	oxidoreductase activity
FZC33_RS17920	COG1051	belongs to the nudix hydrolase family
FZC33_RS17925	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FZC33_RS17930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FZC33_RS17935	COG1376	ErfK ybiS ycfS ynhG family protein
FZC33_RS17945	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FZC33_RS17975	COG4651	solute:proton antiporter activity
FZC33_RS17975	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FZC33_RS17995	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FZC33_RS18000	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FZC33_RS18015	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FZC33_RS18035	COG0028	Belongs to the TPP enzyme family
FZC33_RS18050	COG0400	carboxylic ester hydrolase activity
FZC33_RS18060	COG5598	trimethylamine methyltransferase
FZC33_RS18095	COG1309	transcriptional regulator
FZC33_RS18110	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FZC33_RS18115	COG0735	belongs to the Fur family
FZC33_RS18125	COG0583	DNA-binding transcription factor activity
FZC33_RS18130	COG0300	oxidoreductase activity
FZC33_RS18145	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FZC33_RS18155	COG0583	DNA-binding transcription factor activity
FZC33_RS18160	COG0583	DNA-binding transcription factor activity
FZC33_RS18165	COG0564	pseudouridine synthase activity
FZC33_RS18170	COG0552	protein localization to endoplasmic reticulum
FZC33_RS18175	COG2917	probably involved in intracellular septation
FZC33_RS18210	COG2989	Protein conserved in bacteria
FZC33_RS18215	COG2204	response regulator
FZC33_RS18230	COG1522	sequence-specific DNA binding
FZC33_RS18250	COG1522	sequence-specific DNA binding
FZC33_RS18260	COG0288	reversible hydration of carbon dioxide
FZC33_RS18265	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FZC33_RS18275	COG0402	S-adenosylhomocysteine deaminase activity
FZC33_RS18280	COG0583	DNA-binding transcription factor activity
FZC33_RS18285	COG0735	belongs to the Fur family
FZC33_RS18290	COG2951	lytic endotransglycosylase activity
FZC33_RS18295	COG2096	Adenosyltransferase
FZC33_RS18310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FZC33_RS18315	COG0800	Aldolase
FZC33_RS18325	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FZC33_RS18340	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
FZC33_RS18345	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FZC33_RS18350	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FZC33_RS18360	COG1881	PFAM PEBP family protein
FZC33_RS18405	COG1250	3-hydroxyacyl-CoA dehydrogenase
FZC33_RS18410	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS18420	COG0583	DNA-binding transcription factor activity
FZC33_RS18425	COG0024	Methionine aminopeptidase
FZC33_RS18435	COG1280	lysine exporter protein (LysE YggA)
FZC33_RS18445	COG2223	nitrite transmembrane transporter activity
FZC33_RS18455	COG0251	oxidation-reduction process
FZC33_RS18470	COG0583	DNA-binding transcription factor activity
FZC33_RS18485	COG0431	NADPH-dependent FMN reductase
FZC33_RS18490	COG0798	PFAM Bile acid sodium symporter
FZC33_RS18505	COG0640	Transcriptional regulator
FZC33_RS18520	COG1301	dicarboxylic acid transport
FZC33_RS18525	COG0583	DNA-binding transcription factor activity
FZC33_RS18535	COG2827	Endonuclease containing a URI domain
FZC33_RS18540	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FZC33_RS18545	COG2086	electron transfer activity
FZC33_RS18580	COG0473	3-isopropylmalate dehydrogenase activity
FZC33_RS18585	COG0602	queuosine metabolic process
FZC33_RS18590	COG0720	synthase
FZC33_RS18620	COG1012	belongs to the aldehyde dehydrogenase family
FZC33_RS18630	COG1216	Glycosyl transferase, family 2
FZC33_RS18650	COG0463	Glycosyl transferase, family 2
FZC33_RS18665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FZC33_RS18670	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
FZC33_RS18675	COG3132	Protein of unknown function, DUF480
FZC33_RS18840	COG1216	Glycosyl transferase, family 2
FZC33_RS18890	COG0287	Prephenate dehydrogenase
FZC33_RS18895	COG0625	glutathione transferase activity
FZC33_RS18900	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FZC33_RS18915	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FZC33_RS18920	COG1671	Belongs to the UPF0178 family
FZC33_RS18965	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FZC33_RS18970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FZC33_RS18995	COG0138	bifunctional purine biosynthesis protein purh
FZC33_RS19005	COG2885	chlorophyll binding
FZC33_RS19025	COG0395	ABC-type sugar transport system, permease component
FZC33_RS19040	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS19085	COG0477	Major facilitator Superfamily
FZC33_RS19090	COG0730	response to heat
FZC33_RS19095	COG0583	DNA-binding transcription factor activity
FZC33_RS19100	COG1487	ribonuclease activity
FZC33_RS19125	COG1492	cobalamin metabolic process
FZC33_RS19145	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FZC33_RS19180	COG5598	trimethylamine methyltransferase
FZC33_RS19185	COG1454	alcohol dehydrogenase
FZC33_RS19190	COG1012	belongs to the aldehyde dehydrogenase family
FZC33_RS19195	COG4948	Mandelate Racemase Muconate Lactonizing
FZC33_RS19210	COG0697	spore germination
FZC33_RS19215	COG0583	DNA-binding transcription factor activity
FZC33_RS19225	COG0837	glucose binding
FZC33_RS19230	COG0625	glutathione transferase activity
FZC33_RS19240	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FZC33_RS19270	COG1376	ErfK ybiS ycfS ynhG family protein
FZC33_RS19275	COG0501	Belongs to the peptidase M48B family
FZC33_RS19290	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
FZC33_RS19295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FZC33_RS19315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FZC33_RS19350	COG0861	Integral membrane protein TerC family
FZC33_RS19355	COG1609	Transcriptional regulator
FZC33_RS19360	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FZC33_RS19365	COG2902	Dehydrogenase
FZC33_RS19385	COG2226	methyltransferase
FZC33_RS19390	COG0494	nUDIX hydrolase
FZC33_RS19395	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FZC33_RS19400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FZC33_RS19405	COG0653	protein targeting
FZC33_RS19465	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FZC33_RS19500	COG0457	Tetratricopeptide repeat
FZC33_RS19500	COG0705	Rhomboid family
FZC33_RS19510	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS19525	COG0670	Belongs to the BI1 family
FZC33_RS19530	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FZC33_RS19540	COG1196	nuclear chromosome segregation
FZC33_RS19540	COG3264	Mechanosensitive ion channel
FZC33_RS19555	COG3246	L-lysine catabolic process to acetate
FZC33_RS19560	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FZC33_RS19565	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FZC33_RS19575	COG2207	Transcriptional regulator
FZC33_RS19580	COG0667	Aldo Keto reductase
FZC33_RS19585	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
FZC33_RS19590	COG2154	pterin-4-alpha-carbinolamine dehydratase
FZC33_RS19610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FZC33_RS19620	COG0330	HflC and HflK could
FZC33_RS19625	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FZC33_RS19630	COG2813	Specifically methylates the guanine in position
FZC33_RS19630	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FZC33_RS19655	COG1136	(ABC) transporter
FZC33_RS19665	COG0825	malonyl-CoA metabolic process
FZC33_RS19690	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FZC33_RS19695	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FZC33_RS19700	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FZC33_RS19715	COG3284	Transcriptional regulator
FZC33_RS19720	COG1063	alcohol dehydrogenase
FZC33_RS19765	COG3842	ATPase activity
FZC33_RS19775	COG1840	ABC-type Fe3 transport system, periplasmic component
FZC33_RS19780	COG1609	Transcriptional regulator
FZC33_RS19790	COG0523	cobalamin synthesis protein
FZC33_RS19800	COG1686	Belongs to the peptidase S11 family
FZC33_RS19820	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS19830	COG2076	Multidrug Resistance protein
FZC33_RS19835	COG3158	transport of potassium into the cell
FZC33_RS19840	COG3158	transport of potassium into the cell
FZC33_RS19845	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FZC33_RS19860	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
FZC33_RS19870	COG2884	Cell division ATP-binding protein ftsE
FZC33_RS19930	COG3813	Protein conserved in bacteria
FZC33_RS19935	COG0071	Belongs to the small heat shock protein (HSP20) family
FZC33_RS19945	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FZC33_RS19955	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FZC33_RS19960	COG1012	belongs to the aldehyde dehydrogenase family
FZC33_RS19975	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FZC33_RS19980	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FZC33_RS19985	COG1764	response to oxidative stress
FZC33_RS19995	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FZC33_RS20000	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FZC33_RS20005	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FZC33_RS20010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FZC33_RS20015	COG0583	DNA-binding transcription factor activity
FZC33_RS20035	COG0583	DNA-binding transcription factor activity
FZC33_RS20040	COG2855	membrane
FZC33_RS20050	COG0625	glutathione transferase activity
FZC33_RS20060	COG0488	(ABC) transporter
FZC33_RS20065	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FZC33_RS20070	COG1846	Transcriptional regulator
FZC33_RS20070	COG1940	carbohydrate kinase activity
FZC33_RS20075	COG0673	inositol 2-dehydrogenase activity
FZC33_RS20120	COG0667	Aldo Keto reductase
FZC33_RS20125	COG0656	L-ascorbic acid biosynthetic process
FZC33_RS20130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FZC33_RS20150	COG0793	Belongs to the peptidase S41A family
FZC33_RS20160	COG0697	spore germination
FZC33_RS20170	COG0494	nUDIX hydrolase
FZC33_RS20175	COG0494	nUDIX hydrolase
FZC33_RS20180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FZC33_RS20190	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FZC33_RS20200	COG1012	belongs to the aldehyde dehydrogenase family
FZC33_RS20205	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS20210	COG0583	DNA-binding transcription factor activity
FZC33_RS20215	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FZC33_RS20220	COG4133	protoheme IX ABC transporter activity
FZC33_RS20230	COG2951	lytic endotransglycosylase activity
FZC33_RS20255	COG0070	glutamate synthase
FZC33_RS20255	COG0069	glutamate synthase activity
FZC33_RS20255	COG0067	glutamate synthase
FZC33_RS20260	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS20265	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS20270	COG1129	ABC transporter
FZC33_RS20275	COG1879	ABC-type sugar transport system periplasmic component
FZC33_RS20295	COG1069	ribulokinase activity
FZC33_RS20300	COG2390	Transcriptional regulator
FZC33_RS20305	COG2376	Dihydroxyacetone kinase
FZC33_RS20310	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS20315	COG1129	ABC transporter
FZC33_RS20320	COG1879	ABC-type sugar transport system periplasmic component
FZC33_RS20325	COG1349	DNA-binding transcription factor activity
FZC33_RS20330	COG3347	Dehydrogenase
FZC33_RS20330	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS20350	COG0747	negative chemotaxis
FZC33_RS20355	COG0601	transmembrane transport
FZC33_RS20360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FZC33_RS20375	COG0523	cobalamin synthesis protein
FZC33_RS20410	COG2205	protein histidine kinase activity
FZC33_RS20430	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FZC33_RS20435	COG0668	transmembrane transport
FZC33_RS20450	COG0438	transferase activity, transferring glycosyl groups
FZC33_RS20460	COG1132	(ABC) transporter
FZC33_RS20490	COG0668	transmembrane transport
FZC33_RS20500	COG3698	Phosphodiester glycosidase
FZC33_RS20505	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FZC33_RS20515	COG0799	negative regulation of ribosome biogenesis
FZC33_RS20520	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FZC33_RS20545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FZC33_RS20550	COG0165	Argininosuccinate lyase
FZC33_RS20560	COG0019	diaminopimelate decarboxylase activity
FZC33_RS20580	COG0793	Belongs to the peptidase S41A family
FZC33_RS20605	COG3011	Protein conserved in bacteria
FZC33_RS20610	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FZC33_RS20615	COG3339	Conserved Protein
FZC33_RS20625	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FZC33_RS20685	COG0420	3'-5' exonuclease activity
FZC33_RS20695	COG2066	Belongs to the glutaminase family
FZC33_RS20700	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FZC33_RS20705	COG0228	four-way junction DNA binding
FZC33_RS20710	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FZC33_RS20715	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FZC33_RS20720	COG0336	Belongs to the RNA methyltransferase TrmD family
FZC33_RS20725	COG0335	large ribosomal subunit rRNA binding
FZC33_RS20730	COG4166	transmembrane transport
FZC33_RS20735	COG4166	transmembrane transport
FZC33_RS20750	COG0582	viral genome integration into host DNA
FZC33_RS20770	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FZC33_RS20805	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS20815	COG1917	Cupin 2, conserved barrel domain protein
FZC33_RS20825	COG1176	ABC-type spermidine putrescine transport system, permease component I
FZC33_RS20835	COG3842	ATPase activity
FZC33_RS20840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FZC33_RS20860	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FZC33_RS20875	COG3119	arylsulfatase activity
FZC33_RS20880	COG0583	DNA-binding transcription factor activity
FZC33_RS20890	COG1175	transmembrane transport
FZC33_RS20900	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FZC33_RS20920	COG1247	-acetyltransferase
FZC33_RS20925	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FZC33_RS20945	COG3511	phospholipase C
FZC33_RS20980	COG3220	belongs to the UPF0276 family
FZC33_RS20990	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FZC33_RS21010	COG0446	pyridine nucleotide-disulphide oxidoreductase
FZC33_RS21010	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FZC33_RS21020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FZC33_RS21035	COG0142	geranyltranstransferase activity
FZC33_RS21045	COG0183	Belongs to the thiolase family
FZC33_RS21050	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
FZC33_RS21065	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FZC33_RS21075	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FZC33_RS21090	COG0469	pyruvate kinase activity
FZC33_RS21110	COG3750	Belongs to the UPF0335 family
FZC33_RS21115	COG0789	Transcriptional regulator
FZC33_RS21140	COG2897	thiosulfate sulfurtransferase activity
FZC33_RS21145	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FZC33_RS21150	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FZC33_RS21160	COG1045	serine acetyltransferase
FZC33_RS21170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FZC33_RS21175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FZC33_RS21190	COG1473	amidohydrolase
FZC33_RS21195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FZC33_RS21200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FZC33_RS21215	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FZC33_RS21230	COG1116	anion transmembrane transporter activity
FZC33_RS21230	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FZC33_RS21255	COG2223	nitrite transmembrane transporter activity
FZC33_RS21260	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FZC33_RS21275	COG0243	molybdopterin cofactor binding
FZC33_RS21295	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FZC33_RS21295	COG3743	rRNA binding
FZC33_RS21300	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FZC33_RS21325	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FZC33_RS21340	COG0477	Major facilitator Superfamily
FZC33_RS21345	COG0281	malic enzyme
FZC33_RS21345	COG0280	phosphate acetyltransferase
FZC33_RS21375	COG0297	glycogen (starch) synthase activity
FZC33_RS21385	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FZC33_RS21390	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FZC33_RS21400	COG0708	Exodeoxyribonuclease III
FZC33_RS21415	COG0357	Ribosomal RNA small subunit methyltransferase G
FZC33_RS21420	COG0445	tRNA wobble uridine modification
FZC33_RS21425	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FZC33_RS21430	COG1331	Highly conserved protein containing a thioredoxin domain
FZC33_RS21435	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FZC33_RS21440	COG1981	membrane
FZC33_RS21445	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FZC33_RS21450	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FZC33_RS21475	COG1309	transcriptional regulator
FZC33_RS21500	COG1177	transmembrane transport
FZC33_RS21505	COG1176	ABC-type spermidine putrescine transport system, permease component I
FZC33_RS21510	COG3842	ATPase activity
FZC33_RS21515	COG0424	maF-like protein
FZC33_RS21520	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FZC33_RS21525	COG0237	dephospho-CoA kinase activity
FZC33_RS21530	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FZC33_RS21535	COG0697	spore germination
FZC33_RS21545	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FZC33_RS21550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FZC33_RS21555	COG0800	Aldolase
FZC33_RS21570	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FZC33_RS21595	COG0285	dihydrofolate synthase activity
FZC33_RS21605	COG0791	NLP P60 protein
FZC33_RS21640	COG0154	amidase activity
FZC33_RS21645	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FZC33_RS21660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FZC33_RS21670	COG3842	ATPase activity
FZC33_RS21680	COG1177	transmembrane transport
FZC33_RS21685	COG1176	ABC-type spermidine putrescine transport system, permease component I
FZC33_RS21690	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FZC33_RS21695	COG2211	Major facilitator Superfamily
FZC33_RS21705	COG0583	DNA-binding transcription factor activity
FZC33_RS21710	COG1027	Aspartate ammonia-lyase
FZC33_RS21745	COG1802	Transcriptional regulator
FZC33_RS21750	COG0154	amidase activity
FZC33_RS21770	COG2267	carboxylic ester hydrolase activity
FZC33_RS21775	COG3791	Glutathione-dependent formaldehyde-activating
FZC33_RS21785	COG0481	GTPase activity
FZC33_RS21795	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FZC33_RS21825	COG0606	chelatase, subunit chli
FZC33_RS21840	COG0456	acetyltransferase
FZC33_RS21850	COG2249	NAD(P)H dehydrogenase (quinone) activity
FZC33_RS21860	COG0372	Belongs to the citrate synthase family
FZC33_RS21865	COG0372	Belongs to the citrate synthase family
FZC33_RS21900	COG2900	Belongs to the SlyX family
FZC33_RS21910	COG3459	Glycosyltransferase 36 associated
FZC33_RS21920	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FZC33_RS21920	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FZC33_RS21925	COG4770	biotin carboxylase activity
FZC33_RS21930	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FZC33_RS21935	COG1396	sequence-specific DNA binding
FZC33_RS21935	COG3800	Transcriptional regulator
FZC33_RS21965	COG0583	DNA-binding transcription factor activity
FZC33_RS21970	COG0667	Aldo Keto reductase
FZC33_RS21980	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FZC33_RS21990	COG3008	intermembrane lipid transfer
FZC33_RS21990	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FZC33_RS21995	COG2995	paraquat-inducible protein a
FZC33_RS22010	COG0667	Aldo Keto reductase
FZC33_RS22015	COG2814	Major facilitator Superfamily
FZC33_RS22040	COG2205	protein histidine kinase activity
FZC33_RS22045	COG3178	'Phosphotransferase
FZC33_RS22050	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FZC33_RS22055	COG1280	lysine exporter protein (LysE YggA)
FZC33_RS22065	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FZC33_RS22085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FZC33_RS22090	COG3842	ATPase activity
FZC33_RS22095	COG1177	transmembrane transport
FZC33_RS22100	COG1176	ABC-type spermidine putrescine transport system, permease component I
FZC33_RS22115	COG2807	transmembrane transport
FZC33_RS22140	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FZC33_RS22150	COG0402	S-adenosylhomocysteine deaminase activity
FZC33_RS22155	COG1953	Uracil, thiamine, allantoin
FZC33_RS22170	COG0583	DNA-binding transcription factor activity
FZC33_RS22175	COG3960	tartronate-semialdehyde synthase activity
FZC33_RS22180	COG3622	Belongs to the hyi family
FZC33_RS22185	COG2084	Dehydrogenase
FZC33_RS22200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FZC33_RS22215	COG0583	DNA-binding transcription factor activity
FZC33_RS22220	COG2351	hydroxyisourate hydrolase activity
FZC33_RS22225	COG3648	Uricase
FZC33_RS22225	COG3195	allantoin biosynthetic process
FZC33_RS22230	COG0628	permease
FZC33_RS22255	COG0784	Response regulator, receiver
FZC33_RS22280	COG4191	Histidine kinase
FZC33_RS22280	COG0784	Response regulator, receiver
FZC33_RS22290	COG0018	arginyl-trna synthetase
FZC33_RS22300	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS22310	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS22315	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS22320	COG1129	ABC transporter
FZC33_RS22330	COG3618	amidohydrolase
FZC33_RS22335	COG2186	Transcriptional regulator
FZC33_RS22340	COG3254	rhamnose metabolic process
FZC33_RS22355	COG1217	gtp-binding protein TYPA
FZC33_RS22365	COG2226	methyltransferase
FZC33_RS22375	COG0616	signal peptide processing
FZC33_RS22380	COG0776	regulation of translation
FZC33_RS22390	COG2423	ornithine cyclodeaminase activity
FZC33_RS22400	COG1846	Transcriptional regulator
FZC33_RS22405	COG1764	response to oxidative stress
FZC33_RS22440	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FZC33_RS22445	COG4948	Mandelate Racemase Muconate Lactonizing
FZC33_RS22455	COG1268	BioY protein
FZC33_RS22465	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FZC33_RS22470	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FZC33_RS22475	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FZC33_RS22495	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS22500	COG1129	ABC transporter
FZC33_RS22505	COG0246	Mannitol dehydrogenase
FZC33_RS22510	COG1879	ABC-type sugar transport system periplasmic component
FZC33_RS22515	COG1609	Transcriptional regulator
FZC33_RS22540	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FZC33_RS22555	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FZC33_RS22565	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FZC33_RS22570	COG0756	dUTP diphosphatase activity
FZC33_RS22575	COG1959	2 iron, 2 sulfur cluster binding
FZC33_RS22590	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FZC33_RS22590	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FZC33_RS22605	COG2862	Uncharacterized protein family, UPF0114
FZC33_RS22610	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
FZC33_RS22625	COG3246	L-lysine catabolic process to acetate
FZC33_RS22635	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FZC33_RS22645	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FZC33_RS22650	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FZC33_RS22655	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FZC33_RS22680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FZC33_RS22685	COG1940	carbohydrate kinase activity
FZC33_RS22690	COG1082	Xylose isomerase domain protein TIM barrel
FZC33_RS22700	COG0626	cystathionine gamma-synthase activity
FZC33_RS22705	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FZC33_RS22725	COG0175	sulfate reduction
FZC33_RS22750	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FZC33_RS22755	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FZC33_RS22770	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FZC33_RS22775	COG1137	ATPase activity
FZC33_RS22780	COG4174	ABC transporter (Permease)
FZC33_RS22785	COG4239	(ABC) transporter, permease
FZC33_RS22800	COG0655	NAD(P)H dehydrogenase (quinone) activity
FZC33_RS22855	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FZC33_RS22885	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FZC33_RS22890	COG0725	ABC transporter, periplasmic molybdate-binding protein
FZC33_RS22910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FZC33_RS22920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FZC33_RS22940	COG1802	Transcriptional regulator
FZC33_RS22945	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
FZC33_RS22950	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS22975	COG0395	ABC-type sugar transport system, permease component
FZC33_RS22985	COG2182	Extracellular solute-binding protein
FZC33_RS22995	COG2814	Major facilitator Superfamily
FZC33_RS23000	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FZC33_RS23005	COG0251	oxidation-reduction process
FZC33_RS23010	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FZC33_RS23030	COG2176	DNA-directed DNA polymerase activity
FZC33_RS23035	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FZC33_RS23055	COG0181	hydroxymethylbilane synthase activity
FZC33_RS23065	COG1473	amidohydrolase
FZC33_RS23095	COG0025	NhaP-type Na H and K H
FZC33_RS23100	COG1486	melibiose metabolic process
FZC33_RS23135	COG1070	Carbohydrate kinase
FZC33_RS23140	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FZC33_RS23150	COG0268	Binds directly to 16S ribosomal RNA
FZC33_RS23190	COG3842	ATPase activity
FZC33_RS23200	COG1176	ABC-type spermidine putrescine transport system, permease component I
FZC33_RS23215	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FZC33_RS23220	COG2226	methyltransferase
FZC33_RS23275	COG1012	belongs to the aldehyde dehydrogenase family
FZC33_RS23295	COG0561	phosphatase activity
FZC33_RS23305	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS23315	COG0137	argininosuccinate synthase activity
FZC33_RS23320	COG0248	Ppx GppA phosphatase
FZC33_RS23330	COG1072	(Pantothenic acid kinase))
FZC33_RS23335	COG0140	phosphoribosyl-ATP diphosphatase activity
FZC33_RS23340	COG0107	imidazoleglycerol-phosphate synthase activity
FZC33_RS23345	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FZC33_RS23350	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FZC33_RS23360	COG0131	Imidazoleglycerol-phosphate dehydratase
FZC33_RS23370	COG0189	ligase activity
FZC33_RS23380	COG0747	negative chemotaxis
FZC33_RS23385	COG0601	transmembrane transport
FZC33_RS23390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FZC33_RS23395	COG0444	Belongs to the ABC transporter superfamily
FZC33_RS23400	COG4608	Belongs to the ABC transporter superfamily
FZC33_RS23420	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FZC33_RS23435	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FZC33_RS23450	COG2022	thiamine diphosphate biosynthetic process
FZC33_RS23465	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FZC33_RS23475	COG1070	Carbohydrate kinase
FZC33_RS23480	COG1830	Aldolase
FZC33_RS23485	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FZC33_RS23490	COG0667	Aldo Keto reductase
FZC33_RS23500	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS23505	COG1129	ABC transporter
FZC33_RS23515	COG0427	acetyl-CoA hydrolase
FZC33_RS23535	COG0402	S-adenosylhomocysteine deaminase activity
FZC33_RS23545	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS23555	COG3845	ABC transporter
FZC33_RS23570	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FZC33_RS23575	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FZC33_RS23590	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FZC33_RS23600	COG4221	oxidoreductase activity
FZC33_RS23605	COG4948	Mandelate Racemase Muconate Lactonizing
FZC33_RS23610	COG0395	ABC-type sugar transport system, permease component
FZC33_RS23615	COG1175	transmembrane transport
FZC33_RS23625	COG1802	Transcriptional regulator
FZC33_RS23645	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FZC33_RS23660	COG4608	Belongs to the ABC transporter superfamily
FZC33_RS23665	COG0444	Belongs to the ABC transporter superfamily
FZC33_RS23670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FZC33_RS23675	COG0601	transmembrane transport
FZC33_RS23690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FZC33_RS23740	COG0201	protein transport
FZC33_RS23765	COG0531	amino acid
FZC33_RS23780	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FZC33_RS23785	COG2218	PFAM glutamate synthase alpha subunit domain protein
FZC33_RS23790	COG0069	glutamate synthase activity
FZC33_RS23800	COG1289	transmembrane transporter activity
FZC33_RS23805	COG0583	DNA-binding transcription factor activity
FZC33_RS23850	COG2186	Transcriptional regulator
FZC33_RS23860	COG1129	ABC transporter
FZC33_RS23865	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS23870	COG0326	Molecular chaperone. Has ATPase activity
FZC33_RS23880	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FZC33_RS23880	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FZC33_RS23885	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
FZC33_RS23890	COG2205	protein histidine kinase activity
FZC33_RS23895	COG0745	RESPONSE REGULATOR receiver
FZC33_RS23910	COG4977	sequence-specific DNA binding
FZC33_RS23915	COG2814	Major facilitator Superfamily
FZC33_RS23960	COG1960	acyl-CoA dehydrogenase activity
FZC33_RS23965	COG4821	SIS domain
FZC33_RS23980	COG1309	transcriptional regulator
FZC33_RS24005	COG1074	ATP-dependent DNA helicase activity
FZC33_RS24010	COG1733	regulation of RNA biosynthetic process
FZC33_RS24020	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
FZC33_RS24025	COG4120	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS24030	COG2984	ABC transporter substrate binding protein
FZC33_RS24040	COG0539	negative regulation of cytoplasmic translation
FZC33_RS24055	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FZC33_RS24060	COG3383	formate dehydrogenase (NAD+) activity
FZC33_RS24075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FZC33_RS24085	COG2814	Major facilitator Superfamily
FZC33_RS24090	COG0583	DNA-binding transcription factor activity
FZC33_RS24095	COG3842	ATPase activity
FZC33_RS24100	COG0673	inositol 2-dehydrogenase activity
FZC33_RS24105	COG0395	ABC-type sugar transport system, permease component
FZC33_RS24110	COG1175	transmembrane transport
FZC33_RS24130	COG1349	DNA-binding transcription factor activity
FZC33_RS24135	COG0434	BtpA family
FZC33_RS24140	COG1070	Carbohydrate kinase
FZC33_RS24190	COG3842	ATPase activity
FZC33_RS24200	COG2986	histidine ammonia-lyase
FZC33_RS24230	COG0402	S-adenosylhomocysteine deaminase activity
FZC33_RS24260	COG0477	Major facilitator Superfamily
FZC33_RS24265	COG0583	DNA-binding transcription factor activity
FZC33_RS24280	COG0583	DNA-binding transcription factor activity
FZC33_RS24300	COG4650	regulator
FZC33_RS24310	COG1309	transcriptional regulator
FZC33_RS24345	COG1917	Cupin 2, conserved barrel domain protein
FZC33_RS24345	COG2207	Transcriptional regulator
FZC33_RS24360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FZC33_RS24370	COG0110	maltose O-acetyltransferase activity
FZC33_RS24380	COG0101	tRNA pseudouridine synthase activity
FZC33_RS24385	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FZC33_RS24390	COG0242	peptide deformylase activity
FZC33_RS24395	COG2814	Major facilitator Superfamily
FZC33_RS24415	COG1304	FMN binding
FZC33_RS24440	COG2307	Protein conserved in bacteria
FZC33_RS24440	COG2308	Evidence 4 Homologs of previously reported genes of
FZC33_RS24450	COG0521	Mo-molybdopterin cofactor biosynthetic process
FZC33_RS24465	COG1420	regulation of RNA biosynthetic process
FZC33_RS24475	COG1797	cobyrinic acid a,c-diamide synthase activity
FZC33_RS24480	COG0071	Belongs to the small heat shock protein (HSP20) family
FZC33_RS24495	COG1388	LysM domain
FZC33_RS24495	COG1376	ErfK ybiS ycfS ynhG family protein
FZC33_RS24530	COG0159	tryptophan synthase activity
FZC33_RS24535	COG0133	tryptophan synthase activity
FZC33_RS24540	COG0135	phosphoribosylanthranilate isomerase activity
FZC33_RS24555	COG3386	PFAM SMP-30 Gluconolaconase
FZC33_RS24565	COG0174	glutamine synthetase
FZC33_RS24575	COG2375	cellular response to nickel ion
FZC33_RS24590	COG4178	(ABC) transporter
FZC33_RS24620	COG0456	acetyltransferase
FZC33_RS24625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FZC33_RS24645	COG0300	oxidoreductase activity
FZC33_RS24660	COG1215	transferase activity, transferring glycosyl groups
FZC33_RS24680	COG0156	8-amino-7-oxononanoate synthase activity
FZC33_RS24700	COG2514	catechol 2,3-dioxygenase activity
FZC33_RS24705	COG0435	Glutathione S-transferase
FZC33_RS24710	COG0400	carboxylic ester hydrolase activity
FZC33_RS24730	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FZC33_RS24735	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
FZC33_RS24770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FZC33_RS24770	COG0072	phenylalanine-tRNA ligase activity
FZC33_RS24780	COG0583	DNA-binding transcription factor activity
FZC33_RS24795	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FZC33_RS24805	COG2816	NAD+ diphosphatase activity
FZC33_RS24810	COG1605	Chorismate mutase
FZC33_RS24810	COG0077	Prephenate dehydratase
FZC33_RS24815	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FZC33_RS24825	COG0824	Thioesterase
FZC33_RS24825	COG1250	3-hydroxyacyl-CoA dehydrogenase
FZC33_RS24830	COG3246	L-lysine catabolic process to acetate
FZC33_RS24850	COG0612	Peptidase, M16
FZC33_RS24860	COG4149	molybdate abc transporter
FZC33_RS24870	COG4172	Belongs to the ABC transporter superfamily
FZC33_RS24880	COG5564	TIM-barrel signal transduction protein
FZC33_RS24885	COG5441	Belongs to the UPF0261 family
FZC33_RS24900	COG1335	isochorismatase
FZC33_RS24925	COG2175	clavaminate synthase activity
FZC33_RS24940	COG0668	transmembrane transport
FZC33_RS24945	COG2084	Dehydrogenase
FZC33_RS24950	COG1309	transcriptional regulator
FZC33_RS24960	COG0583	DNA-binding transcription factor activity
FZC33_RS24980	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FZC33_RS24985	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FZC33_RS24990	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FZC33_RS24995	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FZC33_RS25005	COG1214	PFAM Peptidase M22, glycoprotease
FZC33_RS25015	COG4191	Histidine kinase
FZC33_RS25020	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FZC33_RS25025	COG1185	polyribonucleotide nucleotidyltransferase activity
FZC33_RS25040	COG0300	oxidoreductase activity
FZC33_RS25055	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FZC33_RS25060	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FZC33_RS25075	COG1611	Belongs to the LOG family
FZC33_RS25080	COG0640	Transcriptional regulator
FZC33_RS25085	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FZC33_RS25095	COG0477	Major facilitator Superfamily
FZC33_RS25105	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FZC33_RS25110	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FZC33_RS25115	COG0284	orotidine-5'-phosphate decarboxylase activity
FZC33_RS25120	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FZC33_RS25140	COG0180	Tryptophanyl-tRNA synthetase
FZC33_RS25145	COG0625	glutathione transferase activity
FZC33_RS25155	COG1309	transcriptional regulator
FZC33_RS25190	COG0395	ABC-type sugar transport system, permease component
FZC33_RS25225	COG0583	DNA-binding transcription factor activity
FZC33_RS25230	COG0625	glutathione transferase activity
FZC33_RS25240	COG1960	acyl-CoA dehydrogenase activity
FZC33_RS25265	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FZC33_RS25285	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FZC33_RS25285	COG0116	Belongs to the methyltransferase superfamily
FZC33_RS25295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FZC33_RS25320	COG1063	alcohol dehydrogenase
FZC33_RS25330	COG3909	cytochrome
FZC33_RS25335	COG2010	Cytochrome c
FZC33_RS25365	COG0765	amino acid transport
FZC33_RS25370	COG0765	amino acid transport
FZC33_RS25380	COG1446	asparaginase
FZC33_RS25385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FZC33_RS25395	COG1940	carbohydrate kinase activity
FZC33_RS25400	COG3142	Participates in the control of copper homeostasis
FZC33_RS25405	COG0306	phosphate transporter
FZC33_RS25420	COG0513	Belongs to the DEAD box helicase family
FZC33_RS25425	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FZC33_RS25430	COG0235	Class ii aldolase
FZC33_RS25435	COG1464	Belongs to the NlpA lipoprotein family
FZC33_RS25440	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FZC33_RS25445	COG3842	ATPase activity
FZC33_RS25455	COG1175	transmembrane transport
FZC33_RS25460	COG0395	ABC-type sugar transport system, permease component
FZC33_RS25475	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FZC33_RS25480	COG0436	Aminotransferase
FZC33_RS25490	COG1643	Atp-dependent helicase
FZC33_RS25505	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FZC33_RS25510	COG0594	ribonuclease P activity
FZC33_RS25515	COG0706	membrane insertase activity
FZC33_RS25530	COG1522	sequence-specific DNA binding
FZC33_RS25565	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FZC33_RS25570	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FZC33_RS25580	COG0045	succinate-CoA ligase (ADP-forming) activity
FZC33_RS25585	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FZC33_RS25595	COG0508	dehydrogenase complex catalyzes the overall conversion of
FZC33_RS25600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FZC33_RS25635	COG0495	leucyl-tRNA aminoacylation
FZC33_RS25660	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FZC33_RS25675	COG0745	RESPONSE REGULATOR receiver
FZC33_RS25690	COG4581	dead DEAH box helicase
FZC33_RS25700	COG1959	2 iron, 2 sulfur cluster binding
FZC33_RS25705	COG0667	Aldo Keto reductase
FZC33_RS25710	COG3795	YCII-related domain
FZC33_RS25715	COG4941	Belongs to the sigma-70 factor family
FZC33_RS25720	COG0745	RESPONSE REGULATOR receiver
FZC33_RS25725	COG0704	Plays a role in the regulation of phosphate uptake
FZC33_RS25730	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FZC33_RS25735	COG0581	inorganic phosphate transmembrane transporter activity
FZC33_RS25740	COG0573	inorganic phosphate transmembrane transporter activity
FZC33_RS25745	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FZC33_RS25755	COG2326	polyphosphate kinase activity
FZC33_RS25775	COG0583	DNA-binding transcription factor activity
FZC33_RS25780	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FZC33_RS25785	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FZC33_RS25790	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FZC33_RS25795	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FZC33_RS25795	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FZC33_RS25810	COG0779	Required for maturation of 30S ribosomal subunits
FZC33_RS25820	COG1609	Transcriptional regulator
FZC33_RS25830	COG1175	transmembrane transport
FZC33_RS25835	COG0395	ABC-type sugar transport system, permease component
FZC33_RS25840	COG3842	ATPase activity
FZC33_RS25850	COG0673	inositol 2-dehydrogenase activity
FZC33_RS25855	COG3030	protein affecting phage T7 exclusion by the F plasmid
FZC33_RS25880	COG0392	lysyltransferase activity
FZC33_RS25915	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FZC33_RS25930	COG0789	Transcriptional regulator
FZC33_RS25935	COG1960	acyl-CoA dehydrogenase activity
FZC33_RS25940	COG0183	Belongs to the thiolase family
FZC33_RS25955	COG0167	dihydroorotate dehydrogenase activity
FZC33_RS25965	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FZC33_RS25970	COG0792	nuclease activity
FZC33_RS25975	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FZC33_RS25980	COG1335	isochorismatase
FZC33_RS25990	COG4215	(ABC) transporter
FZC33_RS25995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FZC33_RS26030	COG4181	ATPase activity
FZC33_RS26035	COG1597	lipid kinase activity
FZC33_RS26040	COG0671	phosphoesterase, PA-phosphatase related
FZC33_RS26125	COG0235	Class ii aldolase
FZC33_RS26130	COG3395	kinase activity
FZC33_RS26155	COG1250	3-hydroxyacyl-CoA dehydrogenase
FZC33_RS26180	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FZC33_RS26185	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FZC33_RS26205	COG1309	transcriptional regulator
FZC33_RS26220	COG0583	DNA-binding transcription factor activity
FZC33_RS26230	COG1942	4-Oxalocrotonate Tautomerase
FZC33_RS26235	COG0667	Aldo Keto reductase
FZC33_RS26265	COG1116	anion transmembrane transporter activity
FZC33_RS26270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FZC33_RS26290	COG0395	ABC-type sugar transport system, permease component
FZC33_RS26295	COG1175	transmembrane transport
FZC33_RS26300	COG1653	transport
FZC33_RS26305	COG1609	Transcriptional regulator
FZC33_RS26320	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
FZC33_RS26325	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
FZC33_RS26330	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FZC33_RS26335	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FZC33_RS26345	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FZC33_RS26360	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FZC33_RS26365	COG0295	cytidine deaminase activity
FZC33_RS26370	COG1079	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS26375	COG4603	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS26380	COG3845	ABC transporter
FZC33_RS26385	COG1744	ABC transporter substrate-binding protein PnrA-like
FZC33_RS26390	COG1803	Methylglyoxal synthase
FZC33_RS26405	COG0443	Heat shock 70 kDa protein
FZC33_RS26410	COG0484	heat shock protein binding
FZC33_RS26435	COG1120	ATPase activity
FZC33_RS26440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FZC33_RS26445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FZC33_RS26455	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FZC33_RS26460	COG0477	Major facilitator Superfamily
FZC33_RS26465	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FZC33_RS26475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FZC33_RS26480	COG2171	N-acyltransferase activity
FZC33_RS26505	COG0642	Histidine kinase
FZC33_RS26515	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FZC33_RS26520	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
FZC33_RS26560	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FZC33_RS26565	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FZC33_RS26570	COG1396	sequence-specific DNA binding
FZC33_RS26575	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FZC33_RS26580	COG1253	flavin adenine dinucleotide binding
FZC33_RS26595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FZC33_RS26620	COG1999	signal sequence binding
FZC33_RS26640	COG1201	RNA secondary structure unwinding
FZC33_RS26655	COG2226	methyltransferase
FZC33_RS26670	COG1793	dna ligase
FZC33_RS26670	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FZC33_RS26700	COG2814	Major facilitator Superfamily
FZC33_RS26705	COG0534	Mate efflux family protein
FZC33_RS26710	COG4172	Belongs to the ABC transporter superfamily
FZC33_RS26735	COG0601	transmembrane transport
FZC33_RS26740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FZC33_RS26745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FZC33_RS26750	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FZC33_RS26760	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS26770	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS26780	COG4948	Mandelate Racemase Muconate Lactonizing
FZC33_RS26785	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS26810	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FZC33_RS26820	COG2188	Transcriptional regulator
FZC33_RS26825	COG2971	BadF BadG BcrA BcrD
FZC33_RS26830	COG1653	transport
FZC33_RS26835	COG1175	transmembrane transport
FZC33_RS26840	COG0395	ABC-type sugar transport system, permease component
FZC33_RS26850	COG1473	amidohydrolase
FZC33_RS26860	COG2423	ornithine cyclodeaminase activity
FZC33_RS26870	COG4215	(ABC) transporter
FZC33_RS26880	COG1126	abc transporter atp-binding protein
FZC33_RS26885	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FZC33_RS26900	COG1607	acyl-coa hydrolase
FZC33_RS26910	COG2967	ApaG domain
FZC33_RS26920	COG1585	Membrane protein implicated in regulation of membrane protease activity
FZC33_RS26925	COG2268	Band 7 protein
FZC33_RS26930	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FZC33_RS26935	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FZC33_RS26950	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FZC33_RS26955	COG1970	mechanosensitive ion channel activity
FZC33_RS26960	COG0436	Aminotransferase
FZC33_RS26970	COG1278	Cold shock
FZC33_RS26975	COG4178	(ABC) transporter
FZC33_RS26980	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
FZC33_RS26995	COG5328	Belongs to the UPF0262 family
FZC33_RS27000	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FZC33_RS27010	COG0028	Belongs to the TPP enzyme family
FZC33_RS27015	COG3474	cytochrome
FZC33_RS27030	COG1181	Belongs to the D-alanine--D-alanine ligase family
FZC33_RS27035	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FZC33_RS27055	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FZC33_RS27055	COG0475	glutathione-regulated potassium exporter activity
FZC33_RS27060	COG0459	protein refolding
FZC33_RS27065	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FZC33_RS27075	COG0156	8-amino-7-oxononanoate synthase activity
FZC33_RS27080	COG3385	transposase activity
FZC33_RS27090	COG0596	Alpha beta hydrolase
FZC33_RS27110	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FZC33_RS27145	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FZC33_RS27165	COG4948	Mandelate Racemase Muconate Lactonizing
FZC33_RS27180	COG1278	Cold shock
FZC33_RS27200	COG2205	protein histidine kinase activity
FZC33_RS27210	COG0159	tryptophan synthase activity
FZC33_RS27215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FZC33_RS27230	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS27235	COG1129	ABC transporter
FZC33_RS27250	COG0778	Nitroreductase
FZC33_RS27280	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FZC33_RS27300	COG0247	lactate metabolic process
FZC33_RS27305	COG0277	FAD linked oxidase domain protein
FZC33_RS27310	COG0277	FAD linked oxidase domain protein
FZC33_RS27330	COG2372	response to copper ion
FZC33_RS27345	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FZC33_RS27360	COG1175	transmembrane transport
FZC33_RS27370	COG0395	ABC-type sugar transport system, permease component
FZC33_RS27375	COG3842	ATPase activity
FZC33_RS27380	COG1177	transmembrane transport
FZC33_RS27385	COG1176	ABC-type spermidine putrescine transport system, permease component I
FZC33_RS27390	COG3842	ATPase activity
FZC33_RS27395	COG0174	glutamine synthetase
FZC33_RS27400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FZC33_RS27420	COG1794	racemase activity, acting on amino acids and derivatives
FZC33_RS27425	COG1522	sequence-specific DNA binding
FZC33_RS27430	COG1309	transcriptional regulator
FZC33_RS27445	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FZC33_RS27450	COG0424	maF-like protein
FZC33_RS27460	COG0300	oxidoreductase activity
FZC33_RS27475	COG2186	Transcriptional regulator
FZC33_RS27495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FZC33_RS27510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FZC33_RS27515	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FZC33_RS27525	COG0124	histidyl-tRNA synthetase
FZC33_RS27540	COG0590	tRNA wobble adenosine to inosine editing
FZC33_RS27545	COG1187	pseudouridine synthase activity
FZC33_RS27550	COG0742	ribosomal rna small subunit methyltransferase
FZC33_RS27560	COG0612	Peptidase, M16
FZC33_RS27565	COG0612	Peptidase, M16
FZC33_RS27575	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FZC33_RS27585	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FZC33_RS27590	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FZC33_RS27595	COG0625	glutathione transferase activity
FZC33_RS27600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FZC33_RS27610	COG4770	biotin carboxylase activity
FZC33_RS27615	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FZC33_RS27620	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FZC33_RS27625	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
FZC33_RS27680	COG2197	response regulator
FZC33_RS27685	COG3387	PFAM Glycoside hydrolase 15-related
FZC33_RS27715	COG0196	riboflavin kinase activity
FZC33_RS27730	COG0151	Belongs to the GarS family
FZC33_RS27735	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FZC33_RS27745	COG2814	Major facilitator Superfamily
FZC33_RS27760	COG1349	DNA-binding transcription factor activity
FZC33_RS27800	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FZC33_RS27810	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
FZC33_RS27820	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FZC33_RS27825	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FZC33_RS27830	COG0509	glycine decarboxylation via glycine cleavage system
FZC33_RS27835	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FZC33_RS27850	COG0745	RESPONSE REGULATOR receiver
FZC33_RS27875	COG1218	3'(2'),5'-bisphosphate nucleotidase
FZC33_RS27890	COG2313	pseudouridylate synthase activity
FZC33_RS27895	COG1522	sequence-specific DNA binding
FZC33_RS27895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FZC33_RS27915	COG0765	amino acid transport
FZC33_RS27930	COG1902	pentaerythritol trinitrate reductase activity
FZC33_RS27935	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FZC33_RS27955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FZC33_RS28005	COG0235	Class ii aldolase
FZC33_RS28040	COG1609	Transcriptional regulator
FZC33_RS28055	COG1024	Enoyl-CoA hydratase
FZC33_RS28060	COG1012	belongs to the aldehyde dehydrogenase family
FZC33_RS28065	COG1653	transport
FZC33_RS28070	COG1175	transmembrane transport
FZC33_RS28075	COG0395	ABC-type sugar transport system, permease component
FZC33_RS28080	COG3842	ATPase activity
FZC33_RS28140	COG0488	(ABC) transporter
FZC33_RS28145	COG1376	ErfK ybiS ycfS ynhG family protein
FZC33_RS28155	COG0673	inositol 2-dehydrogenase activity
FZC33_RS28160	COG1309	transcriptional regulator
FZC33_RS28165	COG2814	Major facilitator Superfamily
FZC33_RS28170	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS28190	COG1137	ATPase activity
FZC33_RS28195	COG1461	Dihydroxyacetone kinase
FZC33_RS28205	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FZC33_RS28220	COG2376	Dihydroxyacetone kinase
FZC33_RS28225	COG1335	isochorismatase
FZC33_RS28240	COG2814	Major facilitator Superfamily
FZC33_RS28245	COG1012	belongs to the aldehyde dehydrogenase family
FZC33_RS28260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FZC33_RS28265	COG3842	ATPase activity
FZC33_RS28275	COG1176	ABC-type spermidine putrescine transport system, permease component I
FZC33_RS28280	COG1177	transmembrane transport
FZC33_RS28285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FZC33_RS28290	COG1454	alcohol dehydrogenase
FZC33_RS28295	COG2186	Transcriptional regulator
FZC33_RS28305	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FZC33_RS28330	COG0617	tRNA 3'-terminal CCA addition
FZC33_RS28340	COG0494	nUDIX hydrolase
FZC33_RS28350	COG0714	Associated with various cellular activities
FZC33_RS28375	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FZC33_RS28385	COG0408	coproporphyrinogen oxidase activity
FZC33_RS28390	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FZC33_RS28395	COG0723	plastoquinol--plastocyanin reductase activity
FZC33_RS28405	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FZC33_RS28410	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FZC33_RS28415	COG0193	aminoacyl-tRNA hydrolase activity
FZC33_RS28420	COG0012	GTP binding
FZC33_RS28425	COG1609	Transcriptional regulator
FZC33_RS28430	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
FZC33_RS28435	COG3454	Phosphonate metabolism
FZC33_RS28440	COG4778	phosphonate C-P lyase system protein PhnL
FZC33_RS28445	COG4107	phosphonate C-P lyase system protein PhnK
FZC33_RS28455	COG3627	carbon phosphorus lyase activity
FZC33_RS28460	COG3626	phosphonate metabolism
FZC33_RS28465	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
FZC33_RS28470	COG3624	Phosphonate C-P lyase system protein PhnG
FZC33_RS28475	COG2188	Transcriptional regulator
FZC33_RS28485	COG1509	lysine 2,3-aminomutase activity
FZC33_RS28505	COG3639	organic phosphonate transmembrane transporter activity
FZC33_RS28515	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
FZC33_RS28525	COG2030	dehydratase
FZC33_RS28550	COG4172	Belongs to the ABC transporter superfamily
FZC33_RS28555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FZC33_RS28560	COG0601	transmembrane transport
FZC33_RS28570	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FZC33_RS28585	COG1496	oxidoreductase activity
FZC33_RS28600	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FZC33_RS28625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FZC33_RS28660	COG0745	RESPONSE REGULATOR receiver
FZC33_RS28665	COG1846	Transcriptional regulator
FZC33_RS28675	COG0667	Aldo Keto reductase
FZC33_RS28685	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FZC33_RS28700	COG2217	Heavy metal translocating P-type atpase
FZC33_RS28710	COG0583	DNA-binding transcription factor activity
FZC33_RS28720	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS28740	COG3719	Belongs to the RNase T2 family
FZC33_RS28760	COG2957	Belongs to the agmatine deiminase family
FZC33_RS28770	COG0583	DNA-binding transcription factor activity
FZC33_RS28780	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FZC33_RS28790	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS28820	COG0515	serine threonine protein kinase
FZC33_RS28835	COG2885	chlorophyll binding
FZC33_RS28940	COG0583	DNA-binding transcription factor activity
FZC33_RS28950	COG1253	flavin adenine dinucleotide binding
FZC33_RS28975	COG1228	amidohydrolase
FZC33_RS28990	COG1794	racemase activity, acting on amino acids and derivatives
FZC33_RS29000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FZC33_RS29005	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FZC33_RS29020	COG0667	Aldo Keto reductase
FZC33_RS29030	COG1742	UPF0060 membrane protein
FZC33_RS29035	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FZC33_RS29045	COG0058	SHG alpha-glucan phosphorylase activity
FZC33_RS29060	COG4172	Belongs to the ABC transporter superfamily
FZC33_RS29065	COG0444	Belongs to the ABC transporter superfamily
FZC33_RS29070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FZC33_RS29085	COG1609	Transcriptional regulator
FZC33_RS29095	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FZC33_RS29100	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FZC33_RS29105	COG0297	glycogen (starch) synthase activity
FZC33_RS29110	COG0033	Phosphoglucomutase
FZC33_RS29120	COG1523	belongs to the glycosyl hydrolase 13 family
FZC33_RS29140	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FZC33_RS29145	COG2267	carboxylic ester hydrolase activity
FZC33_RS29150	COG2453	phosphatase
FZC33_RS29150	COG0671	phosphoesterase, PA-phosphatase related
FZC33_RS29165	COG4589	Belongs to the CDS family
FZC33_RS29205	COG1917	Cupin 2, conserved barrel domain protein
FZC33_RS29210	COG2188	Transcriptional regulator
FZC33_RS29215	COG3842	ATPase activity
FZC33_RS29220	COG1175	transmembrane transport
FZC33_RS29225	COG0395	ABC-type sugar transport system, permease component
FZC33_RS29235	COG3534	alpha-L-arabinofuranosidase
FZC33_RS29240	COG0025	NhaP-type Na H and K H
FZC33_RS29260	COG0433	COG0433 Predicted ATPase
FZC33_RS29280	COG0728	peptidoglycan biosynthetic process
FZC33_RS29285	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FZC33_RS29295	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FZC33_RS29300	COG4957	zinc ion binding
FZC33_RS29305	COG2166	iron-sulfur cluster assembly
FZC33_RS29315	COG2205	protein histidine kinase activity
FZC33_RS29360	COG2983	Belongs to the UPF0260 family
FZC33_RS29400	COG4235	cytochrome complex assembly
FZC33_RS29405	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FZC33_RS29410	COG1138	Cytochrome C-type biogenesis protein
FZC33_RS29415	COG3088	subunit of a heme lyase
FZC33_RS29420	COG0783	Belongs to the Dps family
FZC33_RS29445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FZC33_RS29450	COG0745	RESPONSE REGULATOR receiver
FZC33_RS29455	COG0642	Histidine kinase
FZC33_RS29460	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FZC33_RS29465	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FZC33_RS29475	COG2205	protein histidine kinase activity
FZC33_RS29475	COG2202	Pas domain
FZC33_RS29480	COG0308	aminopeptidase N
FZC33_RS29490	COG1309	transcriptional regulator
FZC33_RS29495	COG0204	Acyl-transferase
FZC33_RS29495	COG0318	PFAM AMP-dependent synthetase and ligase
FZC33_RS29500	COG0514	ATP-dependent DNA helicase (RecQ)
FZC33_RS29505	COG0523	cobalamin synthesis protein
FZC33_RS29515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FZC33_RS29520	COG1120	ATPase activity
FZC33_RS29525	COG2226	methyltransferase
FZC33_RS29530	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FZC33_RS29535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FZC33_RS29565	COG0493	'glutamate synthase
FZC33_RS29580	COG3186	Phenylalanine-4-hydroxylase
FZC33_RS29585	COG1309	transcriptional regulator
FZC33_RS29595	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FZC33_RS29605	COG1024	Enoyl-CoA hydratase
FZC33_RS29615	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FZC33_RS29620	COG1960	acyl-CoA dehydrogenase activity
FZC33_RS29635	COG0183	Belongs to the thiolase family
FZC33_RS29650	COG0531	amino acid
FZC33_RS29660	COG0154	amidase activity
FZC33_RS29665	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FZC33_RS29680	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FZC33_RS29685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FZC33_RS29690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FZC33_RS29745	COG0667	Aldo Keto reductase
FZC33_RS29750	COG0583	DNA-binding transcription factor activity
FZC33_RS29760	COG1505	serine-type exopeptidase activity
FZC33_RS29765	COG1473	amidohydrolase
FZC33_RS29800	COG0659	secondary active sulfate transmembrane transporter activity
FZC33_RS29805	COG1079	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS29810	COG4603	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS29825	COG0402	S-adenosylhomocysteine deaminase activity
FZC33_RS29830	COG1079	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS29835	COG4603	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS29840	COG3845	ABC transporter
FZC33_RS29850	COG1802	Transcriptional regulator
FZC33_RS29870	COG0625	glutathione transferase activity
FZC33_RS29880	COG2252	PERMEase
FZC33_RS29890	COG0583	DNA-binding transcription factor activity
FZC33_RS29895	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FZC33_RS29905	COG1234	tRNA 3'-trailer cleavage
FZC33_RS29915	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FZC33_RS29920	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FZC33_RS29930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FZC33_RS29935	COG2084	Dehydrogenase
FZC33_RS29955	COG1024	Enoyl-CoA hydratase
FZC33_RS29975	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FZC33_RS29990	COG4689	acetoacetate decarboxylase
FZC33_RS29995	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS30000	COG1376	ErfK ybiS ycfS ynhG family protein
FZC33_RS30005	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS30010	COG0640	Transcriptional regulator
FZC33_RS30040	COG1129	ABC transporter
FZC33_RS30050	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS30060	COG1397	ADP-ribosylglycohydrolase
FZC33_RS30065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FZC33_RS30080	COG1177	transmembrane transport
FZC33_RS30085	COG3842	ATPase activity
FZC33_RS30095	COG1132	(ABC) transporter
FZC33_RS30110	COG0697	spore germination
FZC33_RS30125	COG0546	phosphoglycolate phosphatase activity
FZC33_RS30135	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FZC33_RS30155	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FZC33_RS30160	COG1408	metallophosphoesterase
FZC33_RS30165	COG1408	metallophosphoesterase
FZC33_RS30180	COG0156	8-amino-7-oxononanoate synthase activity
FZC33_RS30190	COG1063	alcohol dehydrogenase
FZC33_RS30195	COG4213	ABC transporter substrate-binding protein
FZC33_RS30200	COG4213	ABC transporter substrate-binding protein
FZC33_RS30210	COG4214	carbohydrate transport
FZC33_RS30225	COG0583	DNA-binding transcription factor activity
FZC33_RS30230	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS30245	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FZC33_RS30250	COG3045	CreA protein
FZC33_RS30260	COG0215	cysteine-tRNA ligase activity
FZC33_RS30265	COG0454	-acetyltransferase
FZC33_RS30270	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FZC33_RS30275	COG2353	YceI-like domain
FZC33_RS30295	COG5265	(ABC) transporter
FZC33_RS30300	COG1215	transferase activity, transferring glycosyl groups
FZC33_RS30305	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FZC33_RS30310	COG0729	surface antigen
FZC33_RS30320	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS30325	COG1763	Mo-molybdopterin cofactor biosynthetic process
FZC33_RS30335	COG0746	molybdenum cofactor guanylyltransferase activity
FZC33_RS30340	COG1132	(ABC) transporter
FZC33_RS30350	COG4143	(ABC) transporter
FZC33_RS30355	COG1178	ABC-type Fe3 transport system permease component
FZC33_RS30365	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
FZC33_RS30370	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FZC33_RS30375	COG2249	NAD(P)H dehydrogenase (quinone) activity
FZC33_RS30380	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FZC33_RS30390	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FZC33_RS30395	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FZC33_RS30400	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FZC33_RS30405	COG1561	YicC-like family, N-terminal region
FZC33_RS30410	COG0194	GDP metabolic process
FZC33_RS30415	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FZC33_RS30420	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FZC33_RS30425	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FZC33_RS30440	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FZC33_RS30450	COG0583	DNA-binding transcription factor activity
FZC33_RS30470	COG0765	amino acid transport
FZC33_RS30490	COG0488	(ABC) transporter
FZC33_RS30505	COG0105	UTP biosynthetic process
FZC33_RS30510	COG4521	taurine ABC transporter
FZC33_RS30515	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FZC33_RS30520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FZC33_RS30530	COG0477	Major facilitator Superfamily
FZC33_RS30540	COG0765	amino acid transport
FZC33_RS30545	COG4597	amino acid ABC transporter
FZC33_RS30550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FZC33_RS30560	COG1174	glycine betaine transport
FZC33_RS30565	COG1125	glycine betaine transport
FZC33_RS30570	COG1174	glycine betaine transport
FZC33_RS30575	COG1732	Glycine betaine
FZC33_RS30610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FZC33_RS30615	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FZC33_RS30620	COG1116	anion transmembrane transporter activity
FZC33_RS30625	COG2252	PERMEase
FZC33_RS30635	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FZC33_RS30640	COG2011	ABC-type metal ion transport system permease component
FZC33_RS30645	COG1464	Belongs to the NlpA lipoprotein family
FZC33_RS30650	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FZC33_RS30675	COG1959	2 iron, 2 sulfur cluster binding
FZC33_RS30685	COG1063	alcohol dehydrogenase
FZC33_RS30690	COG0246	Mannitol dehydrogenase
FZC33_RS30705	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS30710	COG4214	carbohydrate transport
FZC33_RS30715	COG1129	ABC transporter
FZC33_RS30720	COG1063	alcohol dehydrogenase
FZC33_RS30795	COG1335	isochorismatase
FZC33_RS30800	COG0583	DNA-binding transcription factor activity
FZC33_RS30805	COG3126	Type III secretion system lipoprotein chaperone (YscW)
FZC33_RS30810	COG0488	(ABC) transporter
FZC33_RS30845	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FZC33_RS30850	COG0358	DNA primase activity
FZC33_RS30885	COG0505	Belongs to the CarA family
FZC33_RS30895	COG0583	DNA-binding transcription factor activity
FZC33_RS30915	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FZC33_RS30925	COG1522	sequence-specific DNA binding
FZC33_RS30950	COG0697	spore germination
FZC33_RS30955	COG1609	Transcriptional regulator
FZC33_RS30960	COG1653	transport
FZC33_RS30975	COG3842	ATPase activity
FZC33_RS30990	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FZC33_RS31010	COG1609	Transcriptional regulator
FZC33_RS31025	COG1129	ABC transporter
FZC33_RS31030	COG4211	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS31045	COG2373	Large extracellular alpha-helical protein
FZC33_RS31050	COG4953	penicillin-binding protein 1C
FZC33_RS31055	COG1652	LysM domain
FZC33_RS31060	COG2188	Transcriptional regulator
FZC33_RS31075	COG1175	transmembrane transport
FZC33_RS31100	COG0174	glutamine synthetase
FZC33_RS31110	COG1454	alcohol dehydrogenase
FZC33_RS31155	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FZC33_RS31165	COG0741	lytic transglycosylase activity
FZC33_RS31170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FZC33_RS31175	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FZC33_RS31180	COG1573	uracil-dna glycosylase
FZC33_RS31190	COG1758	RNA polymerase activity
FZC33_RS31210	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FZC33_RS31215	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FZC33_RS31220	COG0736	holo-[acyl-carrier-protein] synthase activity
FZC33_RS31225	COG0681	Belongs to the peptidase S26 family
FZC33_RS31230	COG0681	Belongs to the peptidase S26 family
FZC33_RS31235	COG0571	ribonuclease III activity
FZC33_RS31240	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FZC33_RS31245	COG1381	Involved in DNA repair and RecF pathway recombination
FZC33_RS31255	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FZC33_RS31270	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FZC33_RS31275	COG0393	Putative heavy-metal-binding
FZC33_RS31285	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FZC33_RS31295	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FZC33_RS31300	COG0081	regulation of translation
FZC33_RS31310	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FZC33_RS31315	COG0222	ribosome binding
FZC33_RS31320	COG0085	RNA polymerase activity
FZC33_RS31325	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FZC33_RS31330	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FZC33_RS31335	COG0049	tRNA binding
FZC33_RS31340	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FZC33_RS31345	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FZC33_RS31350	COG0051	transcription antitermination factor activity, RNA binding
FZC33_RS31355	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FZC33_RS31360	COG0088	Forms part of the polypeptide exit tunnel
FZC33_RS31365	COG0089	rRNA binding
FZC33_RS31370	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FZC33_RS31375	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FZC33_RS31380	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FZC33_RS31385	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FZC33_RS31390	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FZC33_RS31395	COG0255	Belongs to the universal ribosomal protein uL29 family
FZC33_RS31400	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FZC33_RS31405	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FZC33_RS31410	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FZC33_RS31415	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FZC33_RS31420	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FZC33_RS31425	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FZC33_RS31430	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FZC33_RS31435	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FZC33_RS31440	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FZC33_RS31450	COG0200	Binds to the 23S rRNA
FZC33_RS31455	COG0201	protein transport
FZC33_RS31460	COG0563	adenylate kinase activity
FZC33_RS31465	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FZC33_RS31470	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FZC33_RS31475	COG0202	RNA polymerase activity
FZC33_RS31480	COG0203	ribosomal protein L17
FZC33_RS31485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FZC33_RS31490	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FZC33_RS31530	COG0564	pseudouridine synthase activity
FZC33_RS31545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FZC33_RS31555	COG0583	DNA-binding transcription factor activity
FZC33_RS31570	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FZC33_RS31585	COG4770	biotin carboxylase activity
FZC33_RS31600	COG0321	lipoyl(octanoyl) transferase activity
FZC33_RS31610	COG0726	polysaccharide deacetylase
FZC33_RS31660	COG0512	Glutamine amidotransferase of anthranilate synthase
FZC33_RS31660	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FZC33_RS31670	COG3135	benzoate transporter
FZC33_RS31700	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
FZC33_RS31725	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FZC33_RS31735	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FZC33_RS31740	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
FZC33_RS31740	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FZC33_RS31755	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FZC33_RS31760	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FZC33_RS31775	COG4160	amino acid transport
FZC33_RS31795	COG0688	phosphatidylethanolamine metabolic process
FZC33_RS31800	COG1183	phosphatidylcholine synthase activity
FZC33_RS31805	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FZC33_RS31810	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FZC33_RS31815	COG0346	lactoylglutathione lyase activity
FZC33_RS31820	COG0513	Belongs to the DEAD box helicase family
FZC33_RS31845	COG0538	isocitrate dehydrogenase activity
FZC33_RS31870	COG2954	triphosphatase activity
FZC33_RS31915	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FZC33_RS31925	COG0583	DNA-binding transcription factor activity
FZC33_RS31950	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FZC33_RS31980	COG0047	phosphoribosylformylglycinamidine synthase activity
FZC33_RS31985	COG0583	DNA-binding transcription factor activity
FZC33_RS31990	COG2076	Multidrug Resistance protein
FZC33_RS32000	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FZC33_RS32005	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
FZC33_RS32015	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FZC33_RS32035	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FZC33_RS32050	COG0785	Cytochrome C biogenesis protein
FZC33_RS32055	COG0683	leucine binding
FZC33_RS32090	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FZC33_RS32095	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
FZC33_RS32095	COG3608	succinylglutamate desuccinylase aspartoacylase
FZC33_RS32115	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FZC33_RS32150	COG2259	Doxx family
FZC33_RS32175	COG3842	ATPase activity
FZC33_RS32180	COG0583	DNA-binding transcription factor activity
FZC33_RS32195	COG0277	FAD linked oxidase domain protein
FZC33_RS32215	COG2308	Evidence 4 Homologs of previously reported genes of
FZC33_RS32220	COG2271	Major facilitator Superfamily
FZC33_RS32225	COG0583	DNA-binding transcription factor activity
FZC33_RS32235	COG0494	nUDIX hydrolase
FZC33_RS32240	COG1349	DNA-binding transcription factor activity
FZC33_RS32245	COG2003	Belongs to the UPF0758 family
FZC33_RS32250	COG0024	Methionine aminopeptidase
FZC33_RS32275	COG0489	protein tyrosine kinase activity
FZC33_RS32280	COG1546	Belongs to the CinA family
FZC33_RS32280	COG1058	Belongs to the CinA family
FZC33_RS32285	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
FZC33_RS32310	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FZC33_RS32340	COG2267	carboxylic ester hydrolase activity
FZC33_RS32355	COG0346	lactoylglutathione lyase activity
FZC33_RS32375	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FZC33_RS32385	COG1686	Belongs to the peptidase S11 family
FZC33_RS32390	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FZC33_RS32405	COG1309	transcriptional regulator
FZC33_RS32410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FZC33_RS32415	COG1131	(ABC) transporter
FZC33_RS32420	COG0842	Transport permease protein
FZC33_RS32425	COG0842	Transport permease protein
FZC33_RS32430	COG4948	Mandelate Racemase Muconate Lactonizing
FZC33_RS32440	COG1177	transmembrane transport
FZC33_RS32450	COG3842	ATPase activity
FZC33_RS32465	COG0187	DNA topoisomerase II activity
FZC33_RS32475	COG0671	phosphoesterase, PA-phosphatase related
FZC33_RS32485	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FZC33_RS32485	COG3952	Lipid A Biosynthesis
FZC33_RS32495	COG0626	cystathionine gamma-synthase activity
FZC33_RS32500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FZC33_RS32505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FZC33_RS32510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FZC33_RS32515	COG4597	amino acid ABC transporter
FZC33_RS32520	COG0765	amino acid transport
FZC33_RS32525	COG1126	abc transporter atp-binding protein
FZC33_RS32585	COG1396	sequence-specific DNA binding
FZC33_RS32590	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FZC33_RS32610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FZC33_RS32615	COG3800	Transcriptional regulator
FZC33_RS32615	COG1396	sequence-specific DNA binding
FZC33_RS32625	COG2224	Isocitrate lyase
FZC33_RS32630	COG2204	response regulator
FZC33_RS32635	COG4191	Histidine kinase
FZC33_RS32640	COG1301	dicarboxylic acid transport
FZC33_RS32655	COG0179	Fumarylacetoacetate (FAA) hydrolase
FZC33_RS32665	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FZC33_RS32670	COG0438	transferase activity, transferring glycosyl groups
FZC33_RS32685	COG0633	Ferredoxin
FZC33_RS32690	COG4948	Mandelate Racemase Muconate Lactonizing
FZC33_RS32705	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FZC33_RS32705	COG3218	ABC-type transport auxiliary lipoprotein component
FZC33_RS32715	COG1127	ABC transporter
FZC33_RS32720	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FZC33_RS32730	COG0179	Fumarylacetoacetate (FAA) hydrolase
FZC33_RS32735	COG3034	peptidoglycan biosynthetic process
FZC33_RS32745	COG0492	ferredoxin-NADP+ reductase activity
FZC33_RS32750	COG0589	response to stress
FZC33_RS32790	COG3106	COG3106 Predicted ATPase
FZC33_RS32795	COG3768	UPF0283 membrane protein
FZC33_RS32815	COG1999	signal sequence binding
FZC33_RS32820	COG3474	cytochrome
FZC33_RS32830	COG0583	DNA-binding transcription factor activity
FZC33_RS32835	COG1942	4-Oxalocrotonate Tautomerase
FZC33_RS32850	COG1752	Esterase of the alpha-beta hydrolase superfamily
FZC33_RS32855	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FZC33_RS32865	COG1376	ErfK ybiS ycfS ynhG family protein
FZC33_RS32875	COG0628	permease
FZC33_RS32895	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FZC33_RS32925	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FZC33_RS32930	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FZC33_RS32935	COG0281	malic enzyme
FZC33_RS32935	COG0280	phosphate acetyltransferase
FZC33_RS32945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FZC33_RS32955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FZC33_RS32960	COG2223	nitrite transmembrane transporter activity
FZC33_RS32965	COG0738	Major facilitator superfamily
FZC33_RS32970	COG1349	DNA-binding transcription factor activity
FZC33_RS32975	COG4178	(ABC) transporter
FZC33_RS32985	COG3385	transposase activity
FZC33_RS32990	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS32995	COG1129	ABC transporter
FZC33_RS33005	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FZC33_RS33010	COG2706	6-phosphogluconolactonase activity
FZC33_RS33015	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS33030	COG1923	regulation of RNA biosynthetic process
FZC33_RS33035	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FZC33_RS33040	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FZC33_RS33065	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FZC33_RS33070	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FZC33_RS33085	COG3956	TIGRFAM MazG family protein
FZC33_RS33125	COG0629	single-stranded DNA binding
FZC33_RS33130	COG2095	MarC family integral membrane protein
FZC33_RS33145	COG0504	CTP synthase activity
FZC33_RS33155	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FZC33_RS33160	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FZC33_RS33170	COG0148	phosphopyruvate hydratase activity
FZC33_RS33180	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FZC33_RS33185	COG0022	dehydrogenase e1 component
FZC33_RS33185	COG0508	dehydrogenase complex catalyzes the overall conversion of
FZC33_RS33190	COG0508	dehydrogenase complex catalyzes the overall conversion of
FZC33_RS33200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FZC33_RS33205	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FZC33_RS33225	COG1546	Belongs to the CinA family
FZC33_RS33225	COG1058	Belongs to the CinA family
FZC33_RS33230	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FZC33_RS33230	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FZC33_RS33240	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FZC33_RS33260	COG4106	trans-aconitate 2-methyltransferase activity
FZC33_RS33290	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FZC33_RS33295	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FZC33_RS33300	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FZC33_RS33305	COG0649	NAD binding
FZC33_RS33310	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
FZC33_RS33315	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FZC33_RS33325	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FZC33_RS33330	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FZC33_RS33340	COG0713	ATP synthesis coupled electron transport
FZC33_RS33355	COG1007	ATP synthesis coupled electron transport
FZC33_RS33375	COG0129	dihydroxy-acid dehydratase activity
FZC33_RS33390	COG2945	thiolester hydrolase activity
FZC33_RS33400	COG0719	Fe-S assembly protein
FZC33_RS33405	COG0396	ATPase activity
FZC33_RS33410	COG0719	Fe-S assembly protein
FZC33_RS33415	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FZC33_RS33425	COG0316	Belongs to the HesB IscA family
FZC33_RS33440	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FZC33_RS33440	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FZC33_RS33450	COG0583	DNA-binding transcription factor activity
FZC33_RS33460	COG1612	heme a metabolic process
FZC33_RS33470	COG1832	CoA-binding protein
FZC33_RS33480	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FZC33_RS33485	COG1530	ribonuclease E activity
FZC33_RS33490	COG0860	N-Acetylmuramoyl-L-alanine amidase
FZC33_RS33495	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FZC33_RS33505	COG0483	inositol monophosphate 1-phosphatase activity
FZC33_RS33510	COG1620	l-lactate permease
FZC33_RS33515	COG3243	poly(R)-hydroxyalkanoic acid synthase
FZC33_RS33525	COG0436	Aminotransferase
FZC33_RS33535	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FZC33_RS33535	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FZC33_RS33545	COG0519	Catalyzes the synthesis of GMP from XMP
FZC33_RS33545	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FZC33_RS33555	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS33575	COG0300	oxidoreductase activity
FZC33_RS33580	COG0640	Transcriptional regulator
FZC33_RS33635	COG3842	ATPase activity
FZC33_RS33640	COG0307	riboflavin synthase, alpha
FZC33_RS33650	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FZC33_RS33655	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FZC33_RS33660	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FZC33_RS33665	COG0156	8-amino-7-oxononanoate synthase activity
FZC33_RS33680	COG0789	Transcriptional regulator
FZC33_RS33690	COG2814	Major facilitator Superfamily
FZC33_RS33700	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FZC33_RS33705	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FZC33_RS33725	COG1294	oxidase, subunit
FZC33_RS33730	COG1271	oxidase subunit
FZC33_RS33735	COG4988	ABC transporter
FZC33_RS33745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FZC33_RS33750	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FZC33_RS33760	COG0583	DNA-binding transcription factor activity
FZC33_RS33770	COG1879	ABC-type sugar transport system periplasmic component
FZC33_RS33775	COG1129	ABC transporter
FZC33_RS33780	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS33785	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS33800	COG0251	oxidation-reduction process
FZC33_RS33810	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
FZC33_RS33830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FZC33_RS33835	COG0400	carboxylic ester hydrolase activity
FZC33_RS33840	COG0346	lactoylglutathione lyase activity
FZC33_RS33880	COG3385	transposase activity
FZC33_RS33895	COG1280	lysine exporter protein (LysE YggA)
FZC33_RS33905	COG0435	Glutathione S-transferase
FZC33_RS33910	COG0583	DNA-binding transcription factor activity
FZC33_RS33960	COG1522	sequence-specific DNA binding
FZC33_RS33965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FZC33_RS33970	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FZC33_RS33975	COG2423	ornithine cyclodeaminase activity
FZC33_RS33980	COG0006	proline dipeptidase activity
FZC33_RS33985	COG3608	succinylglutamate desuccinylase aspartoacylase
FZC33_RS33990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FZC33_RS33995	COG0765	amino acid transport
FZC33_RS34000	COG0765	amino acid transport
FZC33_RS34005	COG1126	abc transporter atp-binding protein
FZC33_RS34010	COG1012	belongs to the aldehyde dehydrogenase family
FZC33_RS34015	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FZC33_RS34025	COG2226	methyltransferase
FZC33_RS34075	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FZC33_RS34095	COG4213	ABC transporter substrate-binding protein
FZC33_RS34100	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS34105	COG1129	ABC transporter
FZC33_RS34110	COG1172	Belongs to the binding-protein-dependent transport system permease family
FZC33_RS34115	COG1028	Short-chain dehydrogenase reductase Sdr
FZC33_RS34145	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FZC33_RS34155	COG1538	Outer membrane efflux protein
FZC33_RS34170	COG2897	thiosulfate sulfurtransferase activity
FZC33_RS34180	COG0363	glucosamine-6-phosphate deaminase activity
FZC33_RS34185	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FZC33_RS34190	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FZC33_RS34200	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FZC33_RS34215	COG3622	Belongs to the hyi family
FZC33_RS34225	COG1914	H( )-stimulated, divalent metal cation uptake system
FZC33_RS34235	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FZC33_RS34240	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FZC33_RS34255	COG1160	GTP binding
FZC33_RS34270	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FZC33_RS34300	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FZC33_RS34305	COG0305	Participates in initiation and elongation during chromosome replication
FZC33_RS34310	COG0359	binds to the 23S rRNA
FZC33_RS34320	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FZC33_RS34325	COG0360	Binds together with S18 to 16S ribosomal RNA
FZC33_RS34335	COG1183	phosphatidylcholine synthase activity
FZC33_RS34365	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FZC33_RS34475	COG1309	transcriptional regulator
FZC33_RS34565	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FZC33_RS34585	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FZC33_RS34675	COG2353	YceI-like domain
FZC33_RS34770	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FZC33_RS34770	COG2857	Cytochrome c1
FZC33_RS34775	COG2857	Cytochrome c1
FZC33_RS34775	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis