locus-tag	class	description
LACAL_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LACAL_RS00015	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LACAL_RS00025	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LACAL_RS00040	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LACAL_RS00050	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LACAL_RS00055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LACAL_RS00090	COG0336	Belongs to the RNA methyltransferase TrmD family
LACAL_RS00100	COG0335	large ribosomal subunit rRNA binding
LACAL_RS00155	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LACAL_RS00195	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LACAL_RS00200	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LACAL_RS00205	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LACAL_RS00210	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LACAL_RS00215	COG0561	phosphatase activity
LACAL_RS00220	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LACAL_RS00240	COG0305	Participates in initiation and elongation during chromosome replication
LACAL_RS00245	COG0825	malonyl-CoA metabolic process
LACAL_RS00260	COG0343	queuine tRNA-ribosyltransferase activity
LACAL_RS00265	COG3959	Transketolase, thiamine diphosphate binding domain
LACAL_RS00270	COG3958	Transketolase
LACAL_RS00285	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LACAL_RS00290	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LACAL_RS00295	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LACAL_RS00315	COG1233	COG1233 Phytoene dehydrogenase and related
LACAL_RS00335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LACAL_RS00370	COG0714	Associated with various cellular activities
LACAL_RS00375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LACAL_RS00385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LACAL_RS00420	COG0516	GMP reductase activity
LACAL_RS00420	COG0517	IMP dehydrogenase activity
LACAL_RS00470	COG0167	dihydroorotate dehydrogenase activity
LACAL_RS00475	COG2195	Cleaves the N-terminal amino acid of tripeptides
LACAL_RS00485	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LACAL_RS00495	COG0514	ATP-dependent DNA helicase (RecQ)
LACAL_RS00500	COG0517	IMP dehydrogenase activity
LACAL_RS00500	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LACAL_RS00505	COG0805	protein transport
LACAL_RS00515	COG1137	ATPase activity
LACAL_RS00525	COG1253	flavin adenine dinucleotide binding
LACAL_RS00530	COG1183	phosphatidylcholine synthase activity
LACAL_RS00545	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LACAL_RS00565	COG0438	transferase activity, transferring glycosyl groups
LACAL_RS00595	COG0463	Glycosyl transferase, family 2
LACAL_RS00615	COG2089	acid synthase
LACAL_RS00620	COG1083	cytidylyl-transferase
LACAL_RS00645	COG0463	Glycosyl transferase, family 2
LACAL_RS00690	COG0489	protein tyrosine kinase activity
LACAL_RS00700	COG0488	(ABC) transporter
LACAL_RS00720	COG0653	protein targeting
LACAL_RS00730	COG0739	heme binding
LACAL_RS00745	COG1595	DNA-templated transcription, initiation
LACAL_RS00755	COG1703	isobutyryl-CoA mutase activity
LACAL_RS00760	COG0463	Glycosyl transferase, family 2
LACAL_RS00765	COG3952	Lipid A Biosynthesis
LACAL_RS00765	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LACAL_RS00770	COG0671	phosphoesterase, PA-phosphatase related
LACAL_RS00780	COG0534	Mate efflux family protein
LACAL_RS00785	COG2267	carboxylic ester hydrolase activity
LACAL_RS00795	COG0482	sulfurtransferase activity
LACAL_RS00800	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LACAL_RS00810	COG0706	membrane insertase activity
LACAL_RS00815	COG0504	CTP synthase activity
LACAL_RS00825	COG0583	DNA-binding transcription factor activity
LACAL_RS00830	COG2855	membrane
LACAL_RS00835	COG3530	Putative quorum-sensing-regulated virulence factor
LACAL_RS00845	COG1388	LysM domain
LACAL_RS00845	COG0791	NLP P60 protein
LACAL_RS00850	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LACAL_RS00850	COG0519	Catalyzes the synthesis of GMP from XMP
LACAL_RS00855	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
LACAL_RS00860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LACAL_RS00865	COG0154	amidase activity
LACAL_RS00880	COG0552	protein localization to endoplasmic reticulum
LACAL_RS00885	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LACAL_RS00890	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LACAL_RS00895	COG1058	Belongs to the CinA family
LACAL_RS00895	COG1546	Belongs to the CinA family
LACAL_RS00905	COG0179	Fumarylacetoacetate (FAA) hydrolase
LACAL_RS00920	COG0300	oxidoreductase activity
LACAL_RS00935	COG0508	dehydrogenase complex catalyzes the overall conversion of
LACAL_RS00945	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LACAL_RS00965	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LACAL_RS00985	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
LACAL_RS01010	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LACAL_RS01035	COG0513	Belongs to the DEAD box helicase family
LACAL_RS01050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LACAL_RS01060	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LACAL_RS01070	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LACAL_RS01090	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LACAL_RS01100	COG3956	TIGRFAM MazG family protein
LACAL_RS01110	COG0242	peptide deformylase activity
LACAL_RS01115	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LACAL_RS01120	COG2171	N-acyltransferase activity
LACAL_RS01130	COG1216	Glycosyl transferase, family 2
LACAL_RS01145	COG0463	Glycosyl transferase, family 2
LACAL_RS01145	COG1216	Glycosyl transferase, family 2
LACAL_RS01165	COG2327	Polysaccharide pyruvyl transferase
LACAL_RS01170	COG0009	L-threonylcarbamoyladenylate synthase
LACAL_RS01175	COG0617	tRNA 3'-terminal CCA addition
LACAL_RS01195	COG1131	(ABC) transporter
LACAL_RS01230	COG0556	nucleotide-excision repair
LACAL_RS01250	COG0045	succinate-CoA ligase (ADP-forming) activity
LACAL_RS01260	COG0019	diaminopimelate decarboxylase activity
LACAL_RS01265	COG4191	Histidine kinase
LACAL_RS01270	COG0643	Histidine kinase
LACAL_RS01270	COG0784	Response regulator, receiver
LACAL_RS01270	COG2198	Histidine kinase
LACAL_RS01285	COG2326	polyphosphate kinase activity
LACAL_RS01290	COG2204	response regulator
LACAL_RS01300	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LACAL_RS01300	COG3264	Mechanosensitive ion channel
LACAL_RS01305	COG1668	transmembrane transport
LACAL_RS01310	COG4152	abc transporter atp-binding protein
LACAL_RS01315	COG0484	heat shock protein binding
LACAL_RS01320	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LACAL_RS01345	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LACAL_RS01365	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LACAL_RS01375	COG2814	Major facilitator Superfamily
LACAL_RS01405	COG1595	DNA-templated transcription, initiation
LACAL_RS01410	COG1522	sequence-specific DNA binding
LACAL_RS01420	COG1703	isobutyryl-CoA mutase activity
LACAL_RS01420	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LACAL_RS01420	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LACAL_RS01425	COG0788	formyltetrahydrofolate deformylase activity
LACAL_RS01440	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LACAL_RS01445	COG0284	orotidine-5'-phosphate decarboxylase activity
LACAL_RS01450	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LACAL_RS01465	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LACAL_RS01510	COG0174	glutamine synthetase
LACAL_RS01520	COG2356	endonuclease I
LACAL_RS01560	COG2217	Heavy metal translocating P-type atpase
LACAL_RS01585	COG2132	Multicopper oxidase
LACAL_RS01595	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LACAL_RS01605	COG2217	Heavy metal translocating P-type atpase
LACAL_RS01675	COG1764	response to oxidative stress
LACAL_RS01690	COG2264	protein methyltransferase activity
LACAL_RS01695	COG0149	triose-phosphate isomerase activity
LACAL_RS01715	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LACAL_RS01730	COG1132	(ABC) transporter
LACAL_RS01735	COG0101	tRNA pseudouridine synthase activity
LACAL_RS01755	COG0268	Binds directly to 16S ribosomal RNA
LACAL_RS01765	COG0442	prolyl-tRNA aminoacylation
LACAL_RS01790	COG0302	gtp cyclohydrolase
LACAL_RS01795	COG0215	cysteine-tRNA ligase activity
LACAL_RS01800	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LACAL_RS01805	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LACAL_RS01820	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LACAL_RS01845	COG0187	DNA topoisomerase II activity
LACAL_RS01850	COG0367	asparagine synthase
LACAL_RS01855	COG0602	queuosine metabolic process
LACAL_RS01865	COG0433	COG0433 Predicted ATPase
LACAL_RS01875	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LACAL_RS01880	COG0662	Cupin 2, conserved barrel domain protein
LACAL_RS01880	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LACAL_RS01890	COG1187	pseudouridine synthase activity
LACAL_RS01905	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LACAL_RS01910	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LACAL_RS01950	COG0148	phosphopyruvate hydratase activity
LACAL_RS01955	COG0505	Belongs to the CarA family
LACAL_RS01960	COG0203	ribosomal protein L17
LACAL_RS01965	COG0202	RNA polymerase activity
LACAL_RS01970	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LACAL_RS01975	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LACAL_RS01980	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LACAL_RS01985	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LACAL_RS01995	COG0200	Binds to the 23S rRNA
LACAL_RS02000	COG1841	ribosomal large subunit assembly
LACAL_RS02005	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LACAL_RS02010	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LACAL_RS02015	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LACAL_RS02020	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LACAL_RS02025	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LACAL_RS02030	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LACAL_RS02035	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LACAL_RS02040	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LACAL_RS02045	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LACAL_RS02050	COG0255	Belongs to the universal ribosomal protein uL29 family
LACAL_RS02055	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LACAL_RS02060	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LACAL_RS02065	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LACAL_RS02070	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LACAL_RS02075	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LACAL_RS02080	COG0089	rRNA binding
LACAL_RS02085	COG0088	Forms part of the polypeptide exit tunnel
LACAL_RS02090	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LACAL_RS02095	COG0051	transcription antitermination factor activity, RNA binding
LACAL_RS02100	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LACAL_RS02105	COG0049	tRNA binding
LACAL_RS02110	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LACAL_RS02120	COG1629	transport
LACAL_RS02140	COG1629	transport
LACAL_RS02145	COG0702	epimerase
LACAL_RS02160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LACAL_RS02170	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LACAL_RS02185	COG1011	Hydrolase
LACAL_RS02195	COG2003	Belongs to the UPF0758 family
LACAL_RS02220	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LACAL_RS02230	COG0358	DNA primase activity
LACAL_RS02280	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LACAL_RS02285	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LACAL_RS02290	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LACAL_RS02300	COG1490	D-aminoacyl-tRNA deacylase activity
LACAL_RS02305	COG1162	GTPase activity
LACAL_RS02310	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
LACAL_RS02315	COG0287	Prephenate dehydrogenase
LACAL_RS02320	COG0436	Aminotransferase
LACAL_RS02325	COG0077	Prephenate dehydratase
LACAL_RS02345	COG2895	sulfate adenylyltransferase (ATP) activity
LACAL_RS02365	COG1959	2 iron, 2 sulfur cluster binding
LACAL_RS02370	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LACAL_RS02440	COG1428	Deoxynucleoside kinase
LACAL_RS02445	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LACAL_RS02460	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
LACAL_RS02485	COG3340	Belongs to the peptidase S51 family
LACAL_RS02515	COG1876	peptidase activity
LACAL_RS02520	COG0501	Belongs to the peptidase M48B family
LACAL_RS02525	COG0666	response to abiotic stimulus
LACAL_RS02530	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LACAL_RS02550	COG2363	Small membrane protein
LACAL_RS02555	COG1477	protein flavinylation
LACAL_RS02575	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LACAL_RS02580	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LACAL_RS02585	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LACAL_RS02590	COG1805	sodium ion transport
LACAL_RS02620	COG1012	belongs to the aldehyde dehydrogenase family
LACAL_RS02625	COG0357	Ribosomal RNA small subunit methyltransferase G
LACAL_RS02630	COG3239	Fatty acid desaturase
LACAL_RS02635	COG0436	Aminotransferase
LACAL_RS02650	COG0569	domain protein
LACAL_RS02655	COG2226	methyltransferase
LACAL_RS02665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LACAL_RS02675	COG0191	fructose-bisphosphate aldolase activity
LACAL_RS02680	COG0242	peptide deformylase activity
LACAL_RS02690	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LACAL_RS02695	COG5002	protein histidine kinase activity
LACAL_RS02700	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LACAL_RS02705	COG1185	polyribonucleotide nucleotidyltransferase activity
LACAL_RS02730	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LACAL_RS02735	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LACAL_RS02740	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LACAL_RS02745	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LACAL_RS02750	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LACAL_RS02770	COG1610	YqeY-like protein
LACAL_RS02790	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LACAL_RS02795	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LACAL_RS02800	COG0772	Belongs to the SEDS family
LACAL_RS02805	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LACAL_RS02810	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LACAL_RS02815	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LACAL_RS02820	COG0768	penicillin binding
LACAL_RS02830	COG0275	rRNA processing
LACAL_RS02835	COG2001	Belongs to the MraZ family
LACAL_RS02845	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LACAL_RS02850	COG0564	pseudouridine synthase activity
LACAL_RS02855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LACAL_RS02860	COG0793	Belongs to the peptidase S41A family
LACAL_RS02865	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LACAL_RS02875	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LACAL_RS02880	COG0791	NLP P60 protein
LACAL_RS02895	COG3104	oligopeptide transport
LACAL_RS02900	COG3104	oligopeptide transport
LACAL_RS02905	COG0823	Involved in the tonB-independent uptake of proteins
LACAL_RS02905	COG1506	peptidase
LACAL_RS02925	COG1253	flavin adenine dinucleotide binding
LACAL_RS02950	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LACAL_RS02975	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LACAL_RS02995	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LACAL_RS03000	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LACAL_RS03020	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LACAL_RS03025	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LACAL_RS03030	COG0066	3-isopropylmalate dehydratase activity
LACAL_RS03040	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LACAL_RS03045	COG0347	Belongs to the P(II) protein family
LACAL_RS03050	COG0004	ammonium transporteR
LACAL_RS03060	COG0070	glutamate synthase
LACAL_RS03060	COG0069	glutamate synthase activity
LACAL_RS03060	COG0067	glutamate synthase
LACAL_RS03070	COG0165	Argininosuccinate lyase
LACAL_RS03080	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LACAL_RS03090	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LACAL_RS03100	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LACAL_RS03105	COG0137	argininosuccinate synthase activity
LACAL_RS03115	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LACAL_RS03120	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LACAL_RS03125	COG0440	acetolactate synthase activity
LACAL_RS03130	COG0028	Belongs to the TPP enzyme family
LACAL_RS03135	COG0129	dihydroxy-acid dehydratase activity
LACAL_RS03175	COG4771	TonB-dependent receptor
LACAL_RS03205	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LACAL_RS03220	COG0463	Glycosyl transferase, family 2
LACAL_RS03250	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LACAL_RS03265	COG0463	Glycosyl transferase, family 2
LACAL_RS03270	COG1215	transferase activity, transferring glycosyl groups
LACAL_RS03310	COG0010	Belongs to the arginase family
LACAL_RS03325	COG1187	pseudouridine synthase activity
LACAL_RS03355	COG2081	HI0933 family
LACAL_RS03385	COG0366	Alpha amylase catalytic
LACAL_RS03390	COG1501	Belongs to the glycosyl hydrolase 31 family
LACAL_RS03395	COG0366	Alpha amylase catalytic
LACAL_RS03400	COG1554	hydrolase, family 65, central catalytic
LACAL_RS03405	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LACAL_RS03420	COG1629	transport
LACAL_RS03420	COG4206	TonB-dependent receptor
LACAL_RS03425	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
LACAL_RS03435	COG0366	Alpha amylase catalytic
LACAL_RS03460	COG1408	metallophosphoesterase
LACAL_RS03465	COG3537	Alpha-1,2-mannosidase
LACAL_RS03475	COG1446	asparaginase
LACAL_RS03480	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LACAL_RS03480	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LACAL_RS03485	COG0494	nUDIX hydrolase
LACAL_RS03490	COG1061	Type III restriction enzyme res subunit
LACAL_RS03500	COG1032	radical SAM domain protein
LACAL_RS03505	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LACAL_RS03510	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LACAL_RS03515	COG0052	Belongs to the universal ribosomal protein uS2 family
LACAL_RS03520	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LACAL_RS03525	COG0528	UMP kinase activity
LACAL_RS03530	COG0233	cytoplasmic translational termination
LACAL_RS03550	COG0017	Asparaginyl-tRNA synthetase
LACAL_RS03585	COG0811	peptide transport
LACAL_RS03590	COG0252	asparaginase activity
LACAL_RS03595	COG0084	hydrolase, TatD family'
LACAL_RS03640	COG0508	dehydrogenase complex catalyzes the overall conversion of
LACAL_RS03670	COG1309	transcriptional regulator
LACAL_RS03685	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LACAL_RS03695	COG4771	TonB-dependent receptor
LACAL_RS03700	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LACAL_RS03735	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LACAL_RS03740	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LACAL_RS03750	COG4771	TonB-dependent receptor
LACAL_RS03765	COG1360	Flagellar Motor Protein
LACAL_RS03775	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LACAL_RS03775	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LACAL_RS03785	COG3279	Response regulator of the LytR AlgR family
LACAL_RS03790	COG3275	phosphorelay sensor kinase activity
LACAL_RS03800	COG2095	MarC family integral membrane protein
LACAL_RS03815	COG0793	Belongs to the peptidase S41A family
LACAL_RS03835	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LACAL_RS03840	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LACAL_RS03845	COG0193	aminoacyl-tRNA hydrolase activity
LACAL_RS03850	COG1404	Belongs to the peptidase S8 family
LACAL_RS03850	COG4935	Belongs to the peptidase S8 family
LACAL_RS03860	COG0196	riboflavin kinase activity
LACAL_RS03870	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LACAL_RS03885	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LACAL_RS03890	COG2239	Acts as a magnesium transporter
LACAL_RS03900	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LACAL_RS03935	COG0527	aspartate kinase activity
LACAL_RS03945	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LACAL_RS03965	COG5002	protein histidine kinase activity
LACAL_RS03965	COG2198	Histidine kinase
LACAL_RS03965	COG0784	Response regulator, receiver
LACAL_RS03970	COG4999	Histidine kinase
LACAL_RS03970	COG3437	response regulator, receiver
LACAL_RS03970	COG2205	protein histidine kinase activity
LACAL_RS03970	COG3850	Histidine kinase
LACAL_RS03980	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LACAL_RS03990	COG0792	nuclease activity
LACAL_RS03995	COG1619	proteins homologs of microcin C7 resistance protein MccF
LACAL_RS04000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LACAL_RS04000	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LACAL_RS04020	COG2885	chlorophyll binding
LACAL_RS04025	COG2183	response to ionizing radiation
LACAL_RS04075	COG0166	Belongs to the GPI family
LACAL_RS04085	COG3483	tryptophan 2,3-dioxygenase activity
LACAL_RS04095	COG3185	4-Hydroxyphenylpyruvate dioxygenase
LACAL_RS04100	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LACAL_RS04105	COG1752	Esterase of the alpha-beta hydrolase superfamily
LACAL_RS04110	COG0322	excinuclease ABC activity
LACAL_RS04115	COG4067	protein conserved in archaea
LACAL_RS04115	COG0189	ligase activity
LACAL_RS04120	COG0189	ligase activity
LACAL_RS04130	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LACAL_RS04145	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LACAL_RS04160	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LACAL_RS04165	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LACAL_RS04180	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LACAL_RS04185	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LACAL_RS04190	COG0297	glycogen (starch) synthase activity
LACAL_RS04200	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LACAL_RS04205	COG4771	TonB-dependent receptor
LACAL_RS04235	COG0156	8-amino-7-oxononanoate synthase activity
LACAL_RS04245	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LACAL_RS04250	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LACAL_RS04270	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LACAL_RS04305	COG1381	Involved in DNA repair and RecF pathway recombination
LACAL_RS04325	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LACAL_RS04335	COG0626	cystathionine gamma-synthase activity
LACAL_RS04365	COG1561	YicC-like family, N-terminal region
LACAL_RS04370	COG0194	GDP metabolic process
LACAL_RS04375	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LACAL_RS04385	COG1652	LysM domain
LACAL_RS04395	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LACAL_RS04440	COG1309	transcriptional regulator
LACAL_RS04465	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LACAL_RS04485	COG0659	secondary active sulfate transmembrane transporter activity
LACAL_RS04500	COG0659	secondary active sulfate transmembrane transporter activity
LACAL_RS04525	COG2304	oxidoreductase activity
LACAL_RS04530	COG0655	NAD(P)H dehydrogenase (quinone) activity
LACAL_RS04535	COG2304	oxidoreductase activity
LACAL_RS04550	COG0714	Associated with various cellular activities
LACAL_RS04555	COG4989	oxidoreductase activity
LACAL_RS04560	COG4221	oxidoreductase activity
LACAL_RS04580	COG1012	belongs to the aldehyde dehydrogenase family
LACAL_RS04585	COG1446	asparaginase
LACAL_RS04600	COG2329	Antibiotic biosynthesis monooxygenase
LACAL_RS04605	COG4953	penicillin-binding protein 1C
LACAL_RS04635	COG3842	ATPase activity
LACAL_RS04640	COG1505	serine-type exopeptidase activity
LACAL_RS04645	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LACAL_RS04650	COG1970	mechanosensitive ion channel activity
LACAL_RS04660	COG1435	thymidine kinase activity
LACAL_RS04675	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LACAL_RS04685	COG1573	uracil-dna glycosylase
LACAL_RS04700	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LACAL_RS04700	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LACAL_RS04715	COG0596	Alpha beta hydrolase
LACAL_RS04730	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LACAL_RS04735	COG0720	synthase
LACAL_RS04740	COG0534	Mate efflux family protein
LACAL_RS04745	COG0784	Response regulator, receiver
LACAL_RS04745	COG2205	protein histidine kinase activity
LACAL_RS04765	COG0156	8-amino-7-oxononanoate synthase activity
LACAL_RS04770	COG1074	ATP-dependent DNA helicase activity
LACAL_RS04785	COG0351	phosphomethylpyrimidine kinase
LACAL_RS04790	COG3341	Caulimovirus viroplasmin
LACAL_RS04790	COG0328	RNA-DNA hybrid ribonuclease activity
LACAL_RS04800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LACAL_RS04805	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LACAL_RS04810	COG0571	ribonuclease III activity
LACAL_RS04820	COG0469	pyruvate kinase activity
LACAL_RS04825	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LACAL_RS04830	COG2954	triphosphatase activity
LACAL_RS04845	COG0439	Biotin carboxylase
LACAL_RS04850	COG0511	ligase activity, forming carbon-carbon bonds
LACAL_RS04855	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LACAL_RS04860	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LACAL_RS04870	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LACAL_RS04890	COG0346	lactoylglutathione lyase activity
LACAL_RS04895	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LACAL_RS04905	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LACAL_RS04915	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LACAL_RS04935	COG0481	GTPase activity
LACAL_RS04940	COG3263	regulation of cellular component size
LACAL_RS04950	COG0659	secondary active sulfate transmembrane transporter activity
LACAL_RS04955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LACAL_RS04970	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LACAL_RS05000	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LACAL_RS05040	COG0393	Putative heavy-metal-binding
LACAL_RS05045	COG0557	exoribonuclease II activity
LACAL_RS05050	COG0698	ribose 5-phosphate isomerase
LACAL_RS05060	COG2153	protein acetylation
LACAL_RS05070	COG0793	Belongs to the peptidase S41A family
LACAL_RS05075	COG0594	ribonuclease P activity
LACAL_RS05090	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LACAL_RS05095	COG0445	tRNA wobble uridine modification
LACAL_RS05100	COG2226	methyltransferase
LACAL_RS05115	COG1597	lipid kinase activity
LACAL_RS05120	COG0470	DNA polymerase III
LACAL_RS05130	COG0126	phosphoglycerate kinase activity
LACAL_RS05135	COG1388	LysM domain
LACAL_RS05135	COG0741	lytic transglycosylase activity
LACAL_RS05145	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LACAL_RS05195	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LACAL_RS05230	COG0438	transferase activity, transferring glycosyl groups
LACAL_RS05245	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LACAL_RS05260	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LACAL_RS05270	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LACAL_RS05285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LACAL_RS05295	COG1215	transferase activity, transferring glycosyl groups
LACAL_RS05305	COG0151	Belongs to the GarS family
LACAL_RS05320	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LACAL_RS05335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LACAL_RS05380	COG0356	it plays a direct role in the translocation of protons across the membrane
LACAL_RS05385	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LACAL_RS05390	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LACAL_RS05395	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LACAL_RS05400	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LACAL_RS05405	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LACAL_RS05425	COG0756	dUTP diphosphatase activity
LACAL_RS05430	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LACAL_RS05455	COG1607	acyl-coa hydrolase
LACAL_RS05465	COG0758	DNA mediated transformation
LACAL_RS05465	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LACAL_RS05470	COG0180	Tryptophanyl-tRNA synthetase
LACAL_RS05485	COG1595	DNA-templated transcription, initiation
LACAL_RS05495	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LACAL_RS05505	COG1774	PSP1 C-terminal conserved region
LACAL_RS05535	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LACAL_RS05580	COG1253	flavin adenine dinucleotide binding
LACAL_RS05590	COG0113	porphobilinogen synthase activity
LACAL_RS05595	COG3012	SEC-C Motif Domain Protein
LACAL_RS05600	COG0408	coproporphyrinogen oxidase activity
LACAL_RS05615	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LACAL_RS05620	COG0181	hydroxymethylbilane synthase activity
LACAL_RS05625	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LACAL_RS05645	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LACAL_RS05655	COG1981	membrane
LACAL_RS05665	COG5000	phosphorelay sensor kinase activity
LACAL_RS05670	COG1024	Enoyl-CoA hydratase
LACAL_RS05705	COG1418	mRNA catabolic process
LACAL_RS05725	COG0484	heat shock protein binding
LACAL_RS05745	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LACAL_RS05750	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LACAL_RS05755	COG1121	(ABC) transporter
LACAL_RS05760	COG0803	Belongs to the bacterial solute-binding protein 9 family
LACAL_RS05790	COG1999	signal sequence binding
LACAL_RS05795	COG0750	zinc metalloprotease
LACAL_RS05805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LACAL_RS05825	COG3590	peptidase
LACAL_RS05870	COG0629	single-stranded DNA binding
LACAL_RS05880	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LACAL_RS05885	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LACAL_RS05910	COG2151	metal-sulfur cluster biosynthetic enzyme
LACAL_RS05915	COG2166	iron-sulfur cluster assembly
LACAL_RS05925	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LACAL_RS05930	COG0719	Fe-S assembly protein
LACAL_RS05935	COG0396	ATPase activity
LACAL_RS05945	COG0719	Fe-S assembly protein
LACAL_RS05950	COG0316	Belongs to the HesB IscA family
LACAL_RS05980	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LACAL_RS06000	COG2169	Transcriptional regulator
LACAL_RS06000	COG1917	Cupin 2, conserved barrel domain protein
LACAL_RS06015	COG0527	aspartate kinase activity
LACAL_RS06020	COG0006	proline dipeptidase activity
LACAL_RS06040	COG1053	succinate dehydrogenase
LACAL_RS06045	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LACAL_RS06055	COG3275	phosphorelay sensor kinase activity
LACAL_RS06060	COG3279	Response regulator of the LytR AlgR family
LACAL_RS06065	COG4717	serine-type aminopeptidase activity
LACAL_RS06070	COG0436	Aminotransferase
LACAL_RS06100	COG0423	glycine-tRNA ligase activity
LACAL_RS06110	COG0708	Exodeoxyribonuclease III
LACAL_RS06115	COG0667	Aldo Keto reductase
LACAL_RS06135	COG1530	ribonuclease E activity
LACAL_RS06140	COG0776	regulation of translation
LACAL_RS06150	COG0629	single-stranded DNA binding
LACAL_RS06165	COG2217	Heavy metal translocating P-type atpase
LACAL_RS06175	COG0612	Peptidase, M16
LACAL_RS06180	COG0612	Peptidase, M16
LACAL_RS06190	COG3743	rRNA binding
LACAL_RS06190	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LACAL_RS06195	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LACAL_RS06200	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LACAL_RS06210	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LACAL_RS06220	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
LACAL_RS06245	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LACAL_RS06260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LACAL_RS06280	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LACAL_RS06290	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LACAL_RS06305	COG0519	Catalyzes the synthesis of GMP from XMP
LACAL_RS06320	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LACAL_RS06325	COG1968	undecaprenyl-diphosphatase activity
LACAL_RS06345	COG2177	Part of the ABC transporter FtsEX involved in
LACAL_RS06350	COG0495	leucyl-tRNA aminoacylation
LACAL_RS06375	COG4585	Histidine kinase
LACAL_RS06400	COG1522	sequence-specific DNA binding
LACAL_RS06410	COG2363	Small membrane protein
LACAL_RS06415	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LACAL_RS06430	COG0463	Glycosyl transferase, family 2
LACAL_RS06435	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LACAL_RS06450	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LACAL_RS06475	COG0745	RESPONSE REGULATOR receiver
LACAL_RS06480	COG5002	protein histidine kinase activity
LACAL_RS06490	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LACAL_RS06505	COG0489	protein tyrosine kinase activity
LACAL_RS06515	COG0492	ferredoxin-NADP+ reductase activity
LACAL_RS06520	COG0633	Ferredoxin
LACAL_RS06550	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LACAL_RS06555	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LACAL_RS06560	COG0228	four-way junction DNA binding
LACAL_RS06575	COG0587	DNA-directed DNA polymerase activity
LACAL_RS06585	COG0740	serine-type endopeptidase activity
LACAL_RS06665	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LACAL_RS06670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LACAL_RS06685	COG2315	Protein conserved in bacteria
LACAL_RS06695	COG0784	Response regulator, receiver
LACAL_RS06705	COG4251	negative regulation of phosphorylation
LACAL_RS06715	COG4251	negative regulation of phosphorylation
LACAL_RS06725	COG3279	Response regulator of the LytR AlgR family
LACAL_RS06780	COG0745	RESPONSE REGULATOR receiver
LACAL_RS06790	COG1482	cell wall glycoprotein biosynthetic process
LACAL_RS06795	COG2824	Alkylphosphonate utilization operon protein PhnA
LACAL_RS06825	COG0589	response to stress
LACAL_RS06830	COG0779	Required for maturation of 30S ribosomal subunits
LACAL_RS06835	COG0195	Participates in both transcription termination and antitermination
LACAL_RS06840	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LACAL_RS06855	COG0437	4 iron, 4 sulfur cluster binding
LACAL_RS06880	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LACAL_RS06885	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LACAL_RS06890	COG2255	four-way junction helicase activity
LACAL_RS06895	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LACAL_RS06910	COG0632	four-way junction helicase activity
LACAL_RS06920	COG0509	glycine decarboxylation via glycine cleavage system
LACAL_RS06945	COG0109	protoheme IX farnesyltransferase activity
LACAL_RS06950	COG1845	cytochrome c oxidase, subunit III
LACAL_RS06970	COG1999	signal sequence binding
LACAL_RS06975	COG2322	membrane
LACAL_RS06985	COG1136	(ABC) transporter
LACAL_RS06990	COG1136	(ABC) transporter
LACAL_RS06990	COG0577	efflux transmembrane transporter activity
LACAL_RS06995	COG1136	(ABC) transporter
LACAL_RS06995	COG0577	efflux transmembrane transporter activity
LACAL_RS07000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LACAL_RS07010	COG1214	PFAM Peptidase M22, glycoprotease
LACAL_RS07015	COG0668	transmembrane transport
LACAL_RS07020	COG3759	membrane
LACAL_RS07025	COG1331	Highly conserved protein containing a thioredoxin domain
LACAL_RS07045	COG3275	phosphorelay sensor kinase activity
LACAL_RS07055	COG2197	response regulator
LACAL_RS07060	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LACAL_RS07065	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LACAL_RS07085	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LACAL_RS07095	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LACAL_RS07105	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LACAL_RS07110	COG0596	Alpha beta hydrolase
LACAL_RS07115	COG1950	PFAM Membrane protein of
LACAL_RS07120	COG0544	peptidyl-prolyl cis-trans isomerase activity
LACAL_RS07130	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LACAL_RS07150	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LACAL_RS07165	COG1428	Deoxynucleoside kinase
LACAL_RS07170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LACAL_RS07175	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LACAL_RS07200	COG0525	valine-tRNA ligase activity
LACAL_RS07215	COG0436	Aminotransferase
LACAL_RS07220	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LACAL_RS07225	COG1595	DNA-templated transcription, initiation
LACAL_RS07235	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LACAL_RS07245	COG1216	Glycosyl transferase, family 2
LACAL_RS07255	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LACAL_RS07260	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LACAL_RS07265	COG0784	Response regulator, receiver
LACAL_RS07265	COG2205	protein histidine kinase activity
LACAL_RS07270	COG1663	tetraacyldisaccharide 4'-kinase activity
LACAL_RS07275	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LACAL_RS07300	COG3844	kynureninase activity
LACAL_RS07310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LACAL_RS07330	COG1028	Short-chain dehydrogenase reductase Sdr
LACAL_RS07360	COG2072	flavoprotein involved in K transport
LACAL_RS07370	COG1404	Belongs to the peptidase S8 family
LACAL_RS07375	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LACAL_RS07380	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LACAL_RS07400	COG1595	DNA-templated transcription, initiation
LACAL_RS07405	COG3712	iron ion homeostasis
LACAL_RS07415	COG4771	TonB-dependent receptor
LACAL_RS07420	COG0508	dehydrogenase complex catalyzes the overall conversion of
LACAL_RS07420	COG0022	dehydrogenase e1 component
LACAL_RS07425	COG2086	electron transfer activity
LACAL_RS07430	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LACAL_RS07440	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LACAL_RS07445	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LACAL_RS07455	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LACAL_RS07465	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
LACAL_RS07470	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LACAL_RS07475	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LACAL_RS07485	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LACAL_RS07490	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LACAL_RS07500	COG1519	Transferase
LACAL_RS07515	COG1215	transferase activity, transferring glycosyl groups
LACAL_RS07520	COG0275	rRNA processing
LACAL_RS07530	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LACAL_RS07530	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LACAL_RS07570	COG1510	regulation of RNA biosynthetic process
LACAL_RS07575	COG0339	signal peptide processing
LACAL_RS07580	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LACAL_RS07585	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LACAL_RS07590	COG0563	adenylate kinase activity
LACAL_RS07595	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LACAL_RS07605	COG4206	TonB-dependent receptor
LACAL_RS07605	COG1629	transport
LACAL_RS07615	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LACAL_RS07625	COG0772	Belongs to the SEDS family
LACAL_RS07645	COG1077	Cell shape determining protein MreB Mrl
LACAL_RS07650	COG0138	bifunctional purine biosynthesis protein purh
LACAL_RS07680	COG4771	TonB-dependent receptor
LACAL_RS07690	COG0459	protein refolding
LACAL_RS07695	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LACAL_RS07715	COG3604	Transcriptional regulator
LACAL_RS07720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LACAL_RS07725	COG1754	DNA topoisomerase type I activity
LACAL_RS07725	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LACAL_RS07735	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LACAL_RS07765	COG0488	(ABC) transporter
LACAL_RS07860	COG0006	proline dipeptidase activity
LACAL_RS07930	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LACAL_RS07940	COG1482	cell wall glycoprotein biosynthetic process
LACAL_RS07945	COG1929	Belongs to the glycerate kinase type-1 family
LACAL_RS07950	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LACAL_RS07975	COG2207	Transcriptional regulator
LACAL_RS07995	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LACAL_RS08005	COG1160	GTP binding
LACAL_RS08045	COG0739	heme binding
LACAL_RS08050	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LACAL_RS08070	COG3186	Phenylalanine-4-hydroxylase
LACAL_RS08080	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LACAL_RS08085	COG3396	Phenylacetate-CoA oxygenase
LACAL_RS08090	COG3460	Phenylacetate-CoA oxygenase
LACAL_RS08095	COG3396	Phenylacetate-CoA oxygenase
LACAL_RS08100	COG2151	metal-sulfur cluster biosynthetic enzyme
LACAL_RS08105	COG1024	Enoyl-CoA hydratase
LACAL_RS08110	COG1250	3-hydroxyacyl-CoA dehydrogenase
LACAL_RS08125	COG0183	Belongs to the thiolase family
LACAL_RS08130	COG2030	dehydratase
LACAL_RS08130	COG1012	belongs to the aldehyde dehydrogenase family
LACAL_RS08165	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
LACAL_RS08175	COG1522	sequence-specific DNA binding
LACAL_RS08180	COG0508	dehydrogenase complex catalyzes the overall conversion of
LACAL_RS08185	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LACAL_RS08190	COG0022	dehydrogenase e1 component
LACAL_RS08200	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LACAL_RS08215	COG0351	phosphomethylpyrimidine kinase
LACAL_RS08215	COG0352	thiamine-phosphate diphosphorylase activity
LACAL_RS08220	COG0352	thiamine-phosphate diphosphorylase activity
LACAL_RS08225	COG2022	thiamine diphosphate biosynthetic process
LACAL_RS08230	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LACAL_RS08250	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LACAL_RS08260	COG2515	1-aminocyclopropane-1-carboxylate deaminase
LACAL_RS08265	COG3942	CHAP domain
LACAL_RS08265	COG1388	LysM domain
LACAL_RS08270	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LACAL_RS08290	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LACAL_RS08300	COG0321	lipoyl(octanoyl) transferase activity
LACAL_RS08365	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LACAL_RS08400	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LACAL_RS08405	COG1960	acyl-CoA dehydrogenase activity
LACAL_RS08410	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LACAL_RS08420	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LACAL_RS08425	COG0811	peptide transport
LACAL_RS08430	COG0848	biopolymer transport protein
LACAL_RS08450	COG0285	dihydrofolate synthase activity
LACAL_RS08465	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LACAL_RS08470	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LACAL_RS08485	COG0295	cytidine deaminase activity
LACAL_RS08490	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LACAL_RS08525	COG2205	protein histidine kinase activity
LACAL_RS08530	COG0018	arginyl-trna synthetase
LACAL_RS08550	COG1127	ABC transporter
LACAL_RS08555	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LACAL_RS08570	COG0688	phosphatidylethanolamine metabolic process
LACAL_RS08575	COG4589	Belongs to the CDS family
LACAL_RS08585	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LACAL_RS08590	COG0799	negative regulation of ribosome biogenesis
LACAL_RS08605	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LACAL_RS08625	COG0659	secondary active sulfate transmembrane transporter activity
LACAL_RS08630	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LACAL_RS08640	COG1181	Belongs to the D-alanine--D-alanine ligase family
LACAL_RS08645	COG0515	serine threonine protein kinase
LACAL_RS08645	COG2815	serine threonine protein kinase
LACAL_RS08650	COG0564	pseudouridine synthase activity
LACAL_RS08655	COG3022	response to hydroperoxide
LACAL_RS08670	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LACAL_RS08675	COG0513	Belongs to the DEAD box helicase family
LACAL_RS08685	COG4628	conserved protein (DUF2132)
LACAL_RS08705	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LACAL_RS08710	COG3152	Membrane
LACAL_RS08715	COG0159	tryptophan synthase activity
LACAL_RS08720	COG0133	tryptophan synthase activity
LACAL_RS08725	COG0135	phosphoribosylanthranilate isomerase activity
LACAL_RS08730	COG0134	indole-3-glycerol-phosphate synthase activity
LACAL_RS08735	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LACAL_RS08740	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LACAL_RS08740	COG0512	Glutamine amidotransferase of anthranilate synthase
LACAL_RS08745	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LACAL_RS08750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LACAL_RS08760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LACAL_RS08765	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LACAL_RS08800	COG4771	TonB-dependent receptor
LACAL_RS08805	COG0561	phosphatase activity
LACAL_RS08820	COG2186	Transcriptional regulator
LACAL_RS08825	COG2271	Major facilitator Superfamily
LACAL_RS08830	COG1028	Short-chain dehydrogenase reductase Sdr
LACAL_RS08905	COG0300	oxidoreductase activity
LACAL_RS08935	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LACAL_RS08940	COG1217	gtp-binding protein TYPA
LACAL_RS08965	COG0357	Ribosomal RNA small subunit methyltransferase G
LACAL_RS08975	COG0463	Glycosyl transferase, family 2
LACAL_RS08990	COG2244	polysaccharide biosynthetic process
LACAL_RS09025	COG2884	Cell division ATP-binding protein ftsE
LACAL_RS09040	COG1574	metal-dependent hydrolase with the TIM-barrel fold
LACAL_RS09070	COG3876	Protein conserved in bacteria
LACAL_RS09100	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LACAL_RS09105	COG1115	amino acid carrier protein
LACAL_RS09115	COG1960	acyl-CoA dehydrogenase activity
LACAL_RS09125	COG4974	Belongs to the 'phage' integrase family
LACAL_RS09175	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LACAL_RS09180	COG0081	regulation of translation
LACAL_RS09185	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LACAL_RS09190	COG0222	ribosome binding
LACAL_RS09195	COG0085	RNA polymerase activity
LACAL_RS09200	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LACAL_RS09250	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LACAL_RS09280	COG1073	alpha beta
LACAL_RS09300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LACAL_RS09325	COG1228	amidohydrolase
LACAL_RS09340	COG2195	Cleaves the N-terminal amino acid of tripeptides
LACAL_RS09350	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LACAL_RS09360	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LACAL_RS09365	COG0105	UTP biosynthetic process
LACAL_RS09375	COG1278	Cold shock
LACAL_RS09380	COG1278	Cold shock
LACAL_RS09395	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LACAL_RS09405	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LACAL_RS09420	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LACAL_RS09450	COG0681	Belongs to the peptidase S26 family
LACAL_RS09455	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LACAL_RS09465	COG1475	DNA binding
LACAL_RS09470	COG1192	Involved in chromosome partitioning
LACAL_RS09475	COG0612	Peptidase, M16
LACAL_RS09495	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LACAL_RS09495	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LACAL_RS09505	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LACAL_RS09525	COG2133	pyrroloquinoline quinone binding
LACAL_RS09535	COG1012	belongs to the aldehyde dehydrogenase family
LACAL_RS09585	COG0492	ferredoxin-NADP+ reductase activity
LACAL_RS09650	COG0783	Belongs to the Dps family
LACAL_RS09670	COG0714	Associated with various cellular activities
LACAL_RS09705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LACAL_RS09715	COG1132	(ABC) transporter
LACAL_RS09725	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LACAL_RS09735	COG1862	Preprotein translocase
LACAL_RS09750	COG0339	signal peptide processing
LACAL_RS09755	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LACAL_RS09820	COG3275	phosphorelay sensor kinase activity
LACAL_RS09830	COG3279	Response regulator of the LytR AlgR family
LACAL_RS09910	COG1960	acyl-CoA dehydrogenase activity
LACAL_RS09915	COG0183	Belongs to the thiolase family
LACAL_RS09920	COG1250	3-hydroxyacyl-CoA dehydrogenase
LACAL_RS09920	COG1024	Enoyl-CoA hydratase
LACAL_RS09925	COG1846	Transcriptional regulator
LACAL_RS09950	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LACAL_RS09950	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LACAL_RS10020	COG1132	(ABC) transporter
LACAL_RS10025	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LACAL_RS10040	COG0254	rRNA binding
LACAL_RS10055	COG0747	negative chemotaxis
LACAL_RS10060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LACAL_RS10080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LACAL_RS10095	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LACAL_RS10100	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LACAL_RS10110	COG1607	acyl-coa hydrolase
LACAL_RS10120	COG1322	Protein conserved in bacteria
LACAL_RS10125	COG1120	ATPase activity
LACAL_RS10130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LACAL_RS10155	COG0793	Belongs to the peptidase S41A family
LACAL_RS10155	COG3409	Peptidoglycan-binding domain 1 protein
LACAL_RS10210	COG0488	(ABC) transporter
LACAL_RS10220	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LACAL_RS10295	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LACAL_RS10305	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LACAL_RS10325	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LACAL_RS10330	COG3279	Response regulator of the LytR AlgR family
LACAL_RS10335	COG0360	Binds together with S18 to 16S ribosomal RNA
LACAL_RS10340	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LACAL_RS10345	COG0359	binds to the 23S rRNA
LACAL_RS10355	COG0584	glycerophosphoryl diester phosphodiesterase
LACAL_RS10365	COG0124	histidyl-tRNA synthetase
LACAL_RS10410	COG1028	Short-chain dehydrogenase reductase Sdr
LACAL_RS10415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LACAL_RS10420	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LACAL_RS10435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LACAL_RS10460	COG1131	(ABC) transporter
LACAL_RS10485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LACAL_RS10490	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LACAL_RS10500	COG0726	polysaccharide deacetylase
LACAL_RS10520	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LACAL_RS10530	COG0463	Glycosyl transferase, family 2
LACAL_RS10540	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LACAL_RS10560	COG1609	Transcriptional regulator
LACAL_RS10565	COG4585	Histidine kinase
LACAL_RS10665	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
LACAL_RS10680	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LACAL_RS10795	COG1678	Uncharacterized ACR, COG1678
LACAL_RS10805	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LACAL_RS10810	COG0514	ATP-dependent DNA helicase (RecQ)
LACAL_RS10830	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LACAL_RS10840	COG0415	Belongs to the DNA photolyase family
LACAL_RS10865	COG3046	protein related to deoxyribodipyrimidine photolyase
LACAL_RS10870	COG0415	Belongs to the DNA photolyase family
LACAL_RS10875	COG0702	epimerase
LACAL_RS10920	COG0598	Magnesium transport protein CorA
LACAL_RS10935	COG0424	maF-like protein
LACAL_RS10960	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LACAL_RS10960	COG1333	cytochrome c biogenesis protein
LACAL_RS10965	COG1970	mechanosensitive ion channel activity
LACAL_RS10975	COG0626	cystathionine gamma-synthase activity
LACAL_RS10980	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
LACAL_RS10985	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LACAL_RS10995	COG2234	aminopeptidase activity
LACAL_RS11000	COG2234	aminopeptidase activity
LACAL_RS11015	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LACAL_RS11015	COG1199	ATP-dependent helicase activity
LACAL_RS11030	COG0778	Nitroreductase
LACAL_RS11040	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LACAL_RS11045	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LACAL_RS11045	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LACAL_RS11060	COG1674	ftsk spoiiie
LACAL_RS11070	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
LACAL_RS11075	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LACAL_RS11080	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LACAL_RS11095	COG1012	belongs to the aldehyde dehydrogenase family
LACAL_RS11110	COG2249	NAD(P)H dehydrogenase (quinone) activity
LACAL_RS11130	COG2197	response regulator
LACAL_RS11145	COG4221	oxidoreductase activity
LACAL_RS11160	COG0583	DNA-binding transcription factor activity
LACAL_RS11165	COG1280	lysine exporter protein (LysE YggA)
LACAL_RS11180	COG0450	alkyl hydroperoxide reductase
LACAL_RS11185	COG1757	Na H antiporter
LACAL_RS11195	COG1522	sequence-specific DNA binding
LACAL_RS11210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LACAL_RS11225	COG0513	Belongs to the DEAD box helicase family
LACAL_RS11240	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LACAL_RS11255	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
LACAL_RS11260	COG0542	response to heat
LACAL_RS11320	COG4104	PAAR repeat-containing protein
LACAL_RS11320	COG3209	COG3209 Rhs family protein
LACAL_RS11450	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LACAL_RS11500	COG0606	chelatase, subunit chli
LACAL_RS11530	COG4585	Histidine kinase
LACAL_RS11535	COG1012	belongs to the aldehyde dehydrogenase family
LACAL_RS11540	COG0564	pseudouridine synthase activity
LACAL_RS11545	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LACAL_RS11555	COG1760	l-serine dehydratase
LACAL_RS11560	COG0443	Heat shock 70 kDa protein
LACAL_RS11595	COG1169	isochorismate synthase
LACAL_RS11600	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LACAL_RS11610	COG2996	Protein conserved in bacteria
LACAL_RS11625	COG1575	Belongs to the MenA family. Type 1 subfamily
LACAL_RS11630	COG4948	Mandelate Racemase Muconate Lactonizing
LACAL_RS11645	COG2304	oxidoreductase activity
LACAL_RS11655	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LACAL_RS11670	COG1741	Belongs to the pirin family
LACAL_RS11680	COG0488	(ABC) transporter
LACAL_RS11690	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LACAL_RS11705	COG2337	Toxic component of a toxin-antitoxin (TA) module
LACAL_RS11755	COG0010	Belongs to the arginase family
LACAL_RS11765	COG1228	amidohydrolase
LACAL_RS11800	COG1393	Belongs to the ArsC family
LACAL_RS11810	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LACAL_RS11815	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
LACAL_RS11825	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LACAL_RS11830	COG1770	oligopeptidase
LACAL_RS11840	COG0156	8-amino-7-oxononanoate synthase activity
LACAL_RS11880	COG0513	Belongs to the DEAD box helicase family
LACAL_RS11905	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LACAL_RS11910	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LACAL_RS11915	COG0217	transcriptional regulatory protein
LACAL_RS11925	COG0793	Belongs to the peptidase S41A family
LACAL_RS11930	COG2154	pterin-4-alpha-carbinolamine dehydratase
LACAL_RS11940	COG2066	Belongs to the glutaminase family
LACAL_RS11945	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LACAL_RS11950	COG0006	proline dipeptidase activity
LACAL_RS11995	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LACAL_RS12000	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LACAL_RS12010	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LACAL_RS12020	COG0012	GTP binding
LACAL_RS12040	COG0861	Integral membrane protein TerC family
LACAL_RS12060	COG1522	sequence-specific DNA binding
LACAL_RS12075	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LACAL_RS12090	COG0686	Belongs to the AlaDH PNT family
LACAL_RS12100	COG0802	atpase or kinase
LACAL_RS12105	COG2204	response regulator
LACAL_RS12110	COG1078	dGTPase activity
LACAL_RS12115	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LACAL_RS12120	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LACAL_RS12120	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LACAL_RS12125	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LACAL_RS12130	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LACAL_RS12135	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LACAL_RS12145	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LACAL_RS12150	COG0612	Peptidase, M16
LACAL_RS12155	COG1028	Short-chain dehydrogenase reductase Sdr
LACAL_RS12170	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LACAL_RS12175	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LACAL_RS12180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LACAL_RS12185	COG2827	Endonuclease containing a URI domain
LACAL_RS12190	COG0131	Imidazoleglycerol-phosphate dehydratase
LACAL_RS12205	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LACAL_RS12210	COG0107	imidazoleglycerol-phosphate synthase activity
LACAL_RS12215	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LACAL_RS12215	COG0140	phosphoribosyl-ATP diphosphatase activity
LACAL_RS12235	COG0101	tRNA pseudouridine synthase activity
LACAL_RS12240	COG0783	Belongs to the Dps family
LACAL_RS12245	COG0668	transmembrane transport
LACAL_RS12270	COG1607	acyl-coa hydrolase
LACAL_RS12280	COG0612	Peptidase, M16
LACAL_RS12320	COG1064	alcohol dehydrogenase
LACAL_RS12330	COG1012	belongs to the aldehyde dehydrogenase family
LACAL_RS12335	COG0513	Belongs to the DEAD box helicase family
LACAL_RS12385	COG1733	regulation of RNA biosynthetic process
LACAL_RS12390	COG0778	Nitroreductase
LACAL_RS12395	COG0604	alcohol dehydrogenase
LACAL_RS12415	COG2207	Transcriptional regulator
LACAL_RS12420	COG1024	Enoyl-CoA hydratase
LACAL_RS12435	COG0300	oxidoreductase activity
LACAL_RS12440	COG2095	MarC family integral membrane protein
LACAL_RS12445	COG2249	NAD(P)H dehydrogenase (quinone) activity
LACAL_RS12470	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
LACAL_RS12500	COG2169	Transcriptional regulator
LACAL_RS12500	COG1917	Cupin 2, conserved barrel domain protein
LACAL_RS12520	COG1879	ABC-type sugar transport system periplasmic component
LACAL_RS12530	COG1172	Belongs to the binding-protein-dependent transport system permease family
LACAL_RS12535	COG0246	Mannitol dehydrogenase
LACAL_RS12540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LACAL_RS12550	COG1979	alcohol dehydrogenase
LACAL_RS12555	COG2130	NADP-dependent
LACAL_RS12570	COG1309	transcriptional regulator
LACAL_RS12575	COG1902	pentaerythritol trinitrate reductase activity
LACAL_RS12610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LACAL_RS12665	COG1187	pseudouridine synthase activity
LACAL_RS12670	COG0668	transmembrane transport
LACAL_RS12680	COG1132	(ABC) transporter
LACAL_RS12695	COG1278	Cold shock
LACAL_RS12705	COG0022	dehydrogenase e1 component
LACAL_RS12725	COG0813	purine-nucleoside phosphorylase activity
LACAL_RS12740	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LACAL_RS12745	COG1288	antiporter activity
LACAL_RS12755	COG0300	oxidoreductase activity
LACAL_RS12760	COG1193	negative regulation of DNA recombination
LACAL_RS12765	COG3011	Protein conserved in bacteria
LACAL_RS12780	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
LACAL_RS12785	COG0515	serine threonine protein kinase
LACAL_RS12785	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LACAL_RS12800	COG0189	ligase activity
LACAL_RS12825	COG0189	ligase activity
LACAL_RS12830	COG1301	dicarboxylic acid transport
LACAL_RS12835	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LACAL_RS12845	COG0277	FAD linked oxidase domain protein
LACAL_RS12845	COG0247	lactate metabolic process
LACAL_RS12855	COG0438	transferase activity, transferring glycosyl groups
LACAL_RS12860	COG1472	Belongs to the glycosyl hydrolase 3 family
LACAL_RS12865	COG0560	Phosphoserine phosphatase
LACAL_RS12865	COG3830	Belongs to the UPF0237 family
LACAL_RS12890	COG2181	nitrate reductase activity
LACAL_RS12890	COG0247	lactate metabolic process
LACAL_RS12900	COG0247	lactate metabolic process
LACAL_RS12900	COG2181	nitrate reductase activity
LACAL_RS12910	COG0860	N-Acetylmuramoyl-L-alanine amidase
LACAL_RS12920	COG0251	oxidation-reduction process
LACAL_RS12925	COG1233	COG1233 Phytoene dehydrogenase and related
LACAL_RS12930	COG2095	MarC family integral membrane protein
LACAL_RS12950	COG0205	6-phosphofructokinase activity
LACAL_RS12960	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LACAL_RS12990	COG0628	permease
LACAL_RS13005	COG1201	RNA secondary structure unwinding
LACAL_RS13010	COG1793	dna ligase
LACAL_RS13010	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LACAL_RS13040	COG0183	Belongs to the thiolase family
LACAL_RS13045	COG0791	NLP P60 protein
LACAL_RS13055	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LACAL_RS13060	COG0542	response to heat
LACAL_RS13070	COG2986	histidine ammonia-lyase
LACAL_RS13075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LACAL_RS13080	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LACAL_RS13090	COG0083	homoserine kinase activity
LACAL_RS13095	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LACAL_RS13105	COG0302	gtp cyclohydrolase
LACAL_RS13110	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LACAL_RS13135	COG2198	Histidine kinase
LACAL_RS13135	COG0643	Histidine kinase
LACAL_RS13150	COG1215	transferase activity, transferring glycosyl groups
LACAL_RS13160	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LACAL_RS13200	COG1454	alcohol dehydrogenase
LACAL_RS13215	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LACAL_RS13225	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LACAL_RS13240	COG0742	ribosomal rna small subunit methyltransferase
LACAL_RS13270	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LACAL_RS13305	COG2885	chlorophyll binding
LACAL_RS13315	COG0259	pyridoxamine-phosphate oxidase activity
LACAL_RS13325	COG1234	tRNA 3'-trailer cleavage
LACAL_RS13335	COG0540	Belongs to the ATCase OTCase family
LACAL_RS13340	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LACAL_RS13355	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LACAL_RS13375	COG1388	LysM domain
LACAL_RS13375	COG0791	NLP P60 protein
LACAL_RS13380	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LACAL_RS13385	COG1595	DNA-templated transcription, initiation
LACAL_RS13410	COG2270	Major facilitator Superfamily
LACAL_RS13425	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LACAL_RS13430	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LACAL_RS13435	COG0297	glycogen (starch) synthase activity
LACAL_RS13440	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LACAL_RS13445	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LACAL_RS13460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LACAL_RS13470	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LACAL_RS13485	COG4974	Belongs to the 'phage' integrase family
LACAL_RS13490	COG3290	protein histidine kinase activity
LACAL_RS13495	COG1418	mRNA catabolic process
LACAL_RS13510	COG0739	heme binding
LACAL_RS13520	COG4974	Belongs to the 'phage' integrase family
LACAL_RS13545	COG1028	Short-chain dehydrogenase reductase Sdr
LACAL_RS13560	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LACAL_RS13575	COG1408	metallophosphoesterase
LACAL_RS13595	COG0640	Transcriptional regulator
LACAL_RS13630	COG2207	Transcriptional regulator
LACAL_RS13630	COG0662	Cupin 2, conserved barrel domain protein
LACAL_RS13660	COG2076	Multidrug Resistance protein
LACAL_RS13665	COG0798	PFAM Bile acid sodium symporter
LACAL_RS13675	COG1733	regulation of RNA biosynthetic process
LACAL_RS13705	COG1104	cysteine desulfurase activity
LACAL_RS13740	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LACAL_RS13745	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LACAL_RS13775	COG0116	Belongs to the methyltransferase superfamily
LACAL_RS13795	COG1272	protein, Hemolysin III
LACAL_RS13805	COG1363	Peptidase, m42
LACAL_RS13820	COG2339	peptidase activity
LACAL_RS13830	COG2095	MarC family integral membrane protein
LACAL_RS13835	COG1858	cytochrome C peroxidase
LACAL_RS13845	COG1132	(ABC) transporter
LACAL_RS13850	COG2814	Major facilitator Superfamily
LACAL_RS13895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LACAL_RS13900	COG1115	amino acid carrier protein
LACAL_RS13950	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LACAL_RS13955	COG1702	phosphate starvation-inducible protein PhoH
LACAL_RS13970	COG4221	oxidoreductase activity
LACAL_RS13980	COG0592	DNA-directed DNA polymerase activity
LACAL_RS14005	COG3279	Response regulator of the LytR AlgR family
LACAL_RS14010	COG3275	phosphorelay sensor kinase activity
LACAL_RS14030	COG1294	oxidase, subunit
LACAL_RS14035	COG1271	oxidase subunit
LACAL_RS14040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LACAL_RS14040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LACAL_RS14055	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LACAL_RS14060	COG5002	protein histidine kinase activity
LACAL_RS14065	COG3279	Response regulator of the LytR AlgR family
LACAL_RS14070	COG5002	protein histidine kinase activity
LACAL_RS14090	COG0784	Response regulator, receiver
LACAL_RS14135	COG1506	peptidase
LACAL_RS14140	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LACAL_RS14160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LACAL_RS14170	COG0405	Gamma-glutamyltransferase
LACAL_RS14190	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LACAL_RS14200	COG1611	Belongs to the LOG family
LACAL_RS14225	COG2267	carboxylic ester hydrolase activity
LACAL_RS14245	COG0693	protein deglycase activity
LACAL_RS14275	COG0009	L-threonylcarbamoyladenylate synthase
LACAL_RS14290	COG2197	response regulator
LACAL_RS14295	COG0069	glutamate synthase activity
LACAL_RS14315	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LACAL_RS14435	COG4680	protein conserved in bacteria
LACAL_RS14585	COG0488	(ABC) transporter
LACAL_RS14595	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LACAL_RS14605	COG0300	oxidoreductase activity
LACAL_RS14625	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LACAL_RS14645	COG2201	protein-glutamate methylesterase activity
LACAL_RS14655	COG0542	response to heat
LACAL_RS14670	COG0579	oxidoreductase
LACAL_RS14680	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LACAL_RS14695	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LACAL_RS14700	COG0673	inositol 2-dehydrogenase activity
LACAL_RS14705	COG1250	3-hydroxyacyl-CoA dehydrogenase
LACAL_RS14720	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LACAL_RS14725	COG0322	excinuclease ABC activity
LACAL_RS14730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LACAL_RS14735	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LACAL_RS14755	COG0237	dephospho-CoA kinase activity
LACAL_RS14775	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LACAL_RS14780	COG0497	DNA recombination
LACAL_RS14805	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LACAL_RS14820	COG0737	Belongs to the 5'-nucleotidase family
LACAL_RS14840	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LACAL_RS14845	COG1611	Belongs to the LOG family
LACAL_RS14850	COG2890	protein-(glutamine-N5) methyltransferase activity
LACAL_RS14855	COG0456	acetyltransferase
LACAL_RS14865	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LACAL_RS14865	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LACAL_RS14870	COG1011	Hydrolase
LACAL_RS14880	COG1739	Uncharacterized protein family UPF0029
LACAL_RS14885	COG0824	Thioesterase
LACAL_RS14925	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LACAL_RS14955	COG1309	transcriptional regulator
LACAL_RS15065	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LACAL_RS15070	COG4191	Histidine kinase
LACAL_RS15075	COG4942	peptidase
LACAL_RS15080	COG0791	NLP P60 protein
LACAL_RS15095	COG1388	LysM domain
LACAL_RS15095	COG3942	CHAP domain
LACAL_RS15110	COG2194	sulfuric ester hydrolase activity
LACAL_RS15125	COG3604	Transcriptional regulator
LACAL_RS15130	COG2205	protein histidine kinase activity
LACAL_RS15135	COG4191	Histidine kinase