locus-tag	class	description
CW733_RS00020	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CW733_RS00025	COG1960	acyl-CoA dehydrogenase activity
CW733_RS00035	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CW733_RS00045	COG0811	peptide transport
CW733_RS00050	COG0848	biopolymer transport protein
CW733_RS00065	COG0285	dihydrofolate synthase activity
CW733_RS00080	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CW733_RS00085	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CW733_RS00100	COG0295	cytidine deaminase activity
CW733_RS00105	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CW733_RS00110	COG0508	dehydrogenase complex catalyzes the overall conversion of
CW733_RS00125	COG1028	Short-chain dehydrogenase reductase Sdr
CW733_RS00130	COG5492	domain, Protein
CW733_RS00130	COG4932	domain protein
CW733_RS00175	COG1131	(ABC) transporter
CW733_RS00190	COG1612	heme a metabolic process
CW733_RS00200	COG0617	tRNA 3'-terminal CCA addition
CW733_RS00205	COG0009	L-threonylcarbamoyladenylate synthase
CW733_RS00230	COG1216	Glycosyl transferase, family 2
CW733_RS00245	COG0463	Glycosyl transferase, family 2
CW733_RS00260	COG0463	Glycosyl transferase, family 2
CW733_RS00265	COG0859	PFAM glycosyl transferase family 9
CW733_RS00280	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CW733_RS00285	COG0242	peptide deformylase activity
CW733_RS00295	COG3956	TIGRFAM MazG family protein
CW733_RS00305	COG2936	dipeptidyl-peptidase activity
CW733_RS00315	COG0784	Response regulator, receiver
CW733_RS00315	COG2198	Histidine kinase
CW733_RS00315	COG5002	protein histidine kinase activity
CW733_RS00365	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CW733_RS00375	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CW733_RS00390	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CW733_RS00390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CW733_RS00395	COG1090	epimerase
CW733_RS00415	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CW733_RS00425	COG4152	abc transporter atp-binding protein
CW733_RS00430	COG1668	transmembrane transport
CW733_RS00435	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CW733_RS00435	COG3264	Mechanosensitive ion channel
CW733_RS00455	COG2326	polyphosphate kinase activity
CW733_RS00475	COG0019	diaminopimelate decarboxylase activity
CW733_RS00480	COG0045	succinate-CoA ligase (ADP-forming) activity
CW733_RS00500	COG0556	nucleotide-excision repair
CW733_RS00505	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CW733_RS00510	COG0513	Belongs to the DEAD box helicase family
CW733_RS00520	COG4628	conserved protein (DUF2132)
CW733_RS00535	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CW733_RS00550	COG0159	tryptophan synthase activity
CW733_RS00555	COG0133	tryptophan synthase activity
CW733_RS00560	COG0135	phosphoribosylanthranilate isomerase activity
CW733_RS00565	COG0134	indole-3-glycerol-phosphate synthase activity
CW733_RS00570	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CW733_RS00575	COG0512	Glutamine amidotransferase of anthranilate synthase
CW733_RS00580	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CW733_RS00585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CW733_RS00590	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CW733_RS00620	COG3550	peptidyl-serine autophosphorylation
CW733_RS00630	COG3104	oligopeptide transport
CW733_RS00780	COG3104	oligopeptide transport
CW733_RS00800	COG4774	siderophore transport
CW733_RS00835	COG4974	Belongs to the 'phage' integrase family
CW733_RS00850	COG4974	Belongs to the 'phage' integrase family
CW733_RS00865	COG0300	oxidoreductase activity
CW733_RS00875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CW733_RS00900	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CW733_RS00925	COG2949	membrane
CW733_RS00990	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CW733_RS01000	COG1217	gtp-binding protein TYPA
CW733_RS01055	COG2884	Cell division ATP-binding protein ftsE
CW733_RS01080	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CW733_RS01120	COG3876	Protein conserved in bacteria
CW733_RS01125	COG0577	efflux transmembrane transporter activity
CW733_RS01160	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CW733_RS01165	COG1115	amino acid carrier protein
CW733_RS01170	COG1555	photosystem II stabilization
CW733_RS01175	COG1960	acyl-CoA dehydrogenase activity
CW733_RS01185	COG4974	Belongs to the 'phage' integrase family
CW733_RS01215	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CW733_RS01230	COG0250	Participates in transcription elongation, termination and antitermination
CW733_RS01235	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CW733_RS01240	COG0081	regulation of translation
CW733_RS01245	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CW733_RS01250	COG0222	ribosome binding
CW733_RS01255	COG0085	RNA polymerase activity
CW733_RS01260	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CW733_RS01270	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CW733_RS01290	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CW733_RS01300	COG1482	cell wall glycoprotein biosynthetic process
CW733_RS01330	COG1073	alpha beta
CW733_RS01345	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CW733_RS01355	COG0501	Belongs to the peptidase M48B family
CW733_RS01360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CW733_RS01380	COG1228	amidohydrolase
CW733_RS01395	COG2195	Cleaves the N-terminal amino acid of tripeptides
CW733_RS01410	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CW733_RS01420	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CW733_RS01425	COG0105	UTP biosynthetic process
CW733_RS01435	COG1278	Cold shock
CW733_RS01440	COG1278	Cold shock
CW733_RS01455	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CW733_RS01465	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CW733_RS01480	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CW733_RS01515	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CW733_RS01520	COG0681	Belongs to the peptidase S26 family
CW733_RS01525	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CW733_RS01535	COG1475	DNA binding
CW733_RS01540	COG1192	Involved in chromosome partitioning
CW733_RS01555	COG0612	Peptidase, M16
CW733_RS01630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CW733_RS01640	COG0443	Heat shock 70 kDa protein
CW733_RS01655	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CW733_RS01655	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CW733_RS01665	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CW733_RS01665	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CW733_RS01680	COG2010	Cytochrome c
CW733_RS01685	COG2133	pyrroloquinoline quinone binding
CW733_RS01705	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CW733_RS01710	COG0492	ferredoxin-NADP+ reductase activity
CW733_RS01755	COG0783	Belongs to the Dps family
CW733_RS01760	COG2885	chlorophyll binding
CW733_RS01770	COG0714	Associated with various cellular activities
CW733_RS01810	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CW733_RS01850	COG1252	NADH dehydrogenase
CW733_RS01920	COG3275	phosphorelay sensor kinase activity
CW733_RS01940	COG2184	nucleotidyltransferase activity
CW733_RS01965	COG4206	TonB-dependent receptor
CW733_RS02015	COG1960	acyl-CoA dehydrogenase activity
CW733_RS02020	COG0183	Belongs to the thiolase family
CW733_RS02025	COG1024	Enoyl-CoA hydratase
CW733_RS02025	COG1250	3-hydroxyacyl-CoA dehydrogenase
CW733_RS02030	COG1846	Transcriptional regulator
CW733_RS02045	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CW733_RS02045	COG0047	phosphoribosylformylglycinamidine synthase activity
CW733_RS02055	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CW733_RS02055	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CW733_RS02145	COG1595	DNA-templated transcription, initiation
CW733_RS02150	COG1132	(ABC) transporter
CW733_RS02155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CW733_RS02170	COG0254	rRNA binding
CW733_RS02195	COG4166	transmembrane transport
CW733_RS02205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CW733_RS02225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CW733_RS02235	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CW733_RS02240	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CW733_RS02250	COG1607	acyl-coa hydrolase
CW733_RS02260	COG1322	Protein conserved in bacteria
CW733_RS02265	COG1999	signal sequence binding
CW733_RS02290	COG2205	protein histidine kinase activity
CW733_RS02290	COG0745	RESPONSE REGULATOR receiver
CW733_RS02290	COG3292	Two component regulator propeller
CW733_RS02295	COG1120	ATPase activity
CW733_RS02300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CW733_RS02330	COG1595	DNA-templated transcription, initiation
CW733_RS02375	COG0484	heat shock protein binding
CW733_RS02390	COG0488	(ABC) transporter
CW733_RS02400	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CW733_RS02440	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CW733_RS02450	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CW733_RS02470	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CW733_RS02480	COG3279	Response regulator of the LytR AlgR family
CW733_RS02485	COG0360	Binds together with S18 to 16S ribosomal RNA
CW733_RS02490	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CW733_RS02495	COG0359	binds to the 23S rRNA
CW733_RS02505	COG0584	glycerophosphoryl diester phosphodiesterase
CW733_RS02515	COG0124	histidyl-tRNA synthetase
CW733_RS02555	COG1678	Uncharacterized ACR, COG1678
CW733_RS02565	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CW733_RS02570	COG0514	ATP-dependent DNA helicase (RecQ)
CW733_RS02590	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CW733_RS02595	COG0598	Magnesium transport protein CorA
CW733_RS02610	COG0424	maF-like protein
CW733_RS02635	COG1333	cytochrome c biogenesis protein
CW733_RS02635	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CW733_RS02645	COG1970	mechanosensitive ion channel activity
CW733_RS02655	COG0626	cystathionine gamma-synthase activity
CW733_RS02660	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
CW733_RS02665	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CW733_RS02715	COG2234	aminopeptidase activity
CW733_RS02720	COG2234	aminopeptidase activity
CW733_RS02720	COG4935	Belongs to the peptidase S8 family
CW733_RS02740	COG0322	excinuclease ABC activity
CW733_RS02750	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CW733_RS02780	COG3278	Belongs to the heme-copper respiratory oxidase family
CW733_RS02795	COG2217	Heavy metal translocating P-type atpase
CW733_RS02805	COG0589	response to stress
CW733_RS02815	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CW733_RS02820	COG1127	ABC transporter
CW733_RS02840	COG0517	IMP dehydrogenase activity
CW733_RS02855	COG0589	response to stress
CW733_RS02900	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CW733_RS02955	COG4591	ABC-type transport system involved in lipoprotein release permease component
CW733_RS02965	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CW733_RS02970	COG3118	belongs to the thioredoxin family
CW733_RS02990	COG2205	protein histidine kinase activity
CW733_RS03010	COG0589	response to stress
CW733_RS03020	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CW733_RS03055	COG2010	Cytochrome c
CW733_RS03060	COG3256	nitric oxide reductase
CW733_RS03070	COG0714	Associated with various cellular activities
CW733_RS03080	COG1845	cytochrome c oxidase, subunit III
CW733_RS03100	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
CW733_RS03110	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CW733_RS03115	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CW733_RS03150	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CW733_RS03160	COG2267	carboxylic ester hydrolase activity
CW733_RS03175	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CW733_RS03215	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CW733_RS03240	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CW733_RS03240	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CW733_RS03255	COG1674	ftsk spoiiie
CW733_RS03265	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CW733_RS03270	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CW733_RS03280	COG4628	conserved protein (DUF2132)
CW733_RS03330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CW733_RS03335	COG0450	alkyl hydroperoxide reductase
CW733_RS03340	COG1757	Na H antiporter
CW733_RS03345	COG2095	MarC family integral membrane protein
CW733_RS03350	COG0626	cystathionine gamma-synthase activity
CW733_RS03355	COG1522	sequence-specific DNA binding
CW733_RS03365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CW733_RS03370	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CW733_RS03385	COG3279	Response regulator of the LytR AlgR family
CW733_RS03405	COG0513	Belongs to the DEAD box helicase family
CW733_RS03420	COG0037	tRNA processing
CW733_RS03430	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CW733_RS03445	COG0606	chelatase, subunit chli
CW733_RS03480	COG1012	belongs to the aldehyde dehydrogenase family
CW733_RS03485	COG0564	pseudouridine synthase activity
CW733_RS03495	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CW733_RS03505	COG1760	l-serine dehydratase
CW733_RS03515	COG0443	Heat shock 70 kDa protein
CW733_RS03525	COG2070	2-Nitropropane dioxygenase
CW733_RS03550	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CW733_RS03555	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CW733_RS03580	COG1575	Belongs to the MenA family. Type 1 subfamily
CW733_RS03590	COG4948	Mandelate Racemase Muconate Lactonizing
CW733_RS03615	COG2304	oxidoreductase activity
CW733_RS03620	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CW733_RS03640	COG0488	(ABC) transporter
CW733_RS03650	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CW733_RS03670	COG0494	nUDIX hydrolase
CW733_RS03705	COG0010	Belongs to the arginase family
CW733_RS03720	COG1228	amidohydrolase
CW733_RS03750	COG1393	Belongs to the ArsC family
CW733_RS03755	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CW733_RS03760	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CW733_RS03770	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CW733_RS03775	COG1770	oligopeptidase
CW733_RS03785	COG0156	8-amino-7-oxononanoate synthase activity
CW733_RS03790	COG0456	acetyltransferase
CW733_RS03825	COG0513	Belongs to the DEAD box helicase family
CW733_RS03845	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CW733_RS03860	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CW733_RS03865	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CW733_RS03875	COG4771	TonB-dependent receptor
CW733_RS03900	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CW733_RS03905	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CW733_RS03915	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CW733_RS03935	COG4771	TonB-dependent receptor
CW733_RS03940	COG0012	GTP binding
CW733_RS03960	COG0861	Integral membrane protein TerC family
CW733_RS03980	COG1522	sequence-specific DNA binding
CW733_RS03995	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CW733_RS04000	COG0506	proline dehydrogenase activity
CW733_RS04010	COG0686	Belongs to the AlaDH PNT family
CW733_RS04020	COG0802	atpase or kinase
CW733_RS04025	COG2204	response regulator
CW733_RS04030	COG1078	dGTPase activity
CW733_RS04035	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CW733_RS04040	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CW733_RS04040	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CW733_RS04045	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CW733_RS04050	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CW733_RS04055	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CW733_RS04065	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CW733_RS04070	COG1028	Short-chain dehydrogenase reductase Sdr
CW733_RS04090	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CW733_RS04095	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CW733_RS04100	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CW733_RS04105	COG0322	excinuclease ABC activity
CW733_RS04110	COG0131	Imidazoleglycerol-phosphate dehydratase
CW733_RS04120	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CW733_RS04125	COG0107	imidazoleglycerol-phosphate synthase activity
CW733_RS04130	COG0140	phosphoribosyl-ATP diphosphatase activity
CW733_RS04130	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CW733_RS04145	COG0783	Belongs to the Dps family
CW733_RS04150	COG0668	transmembrane transport
CW733_RS04185	COG1607	acyl-coa hydrolase
CW733_RS04190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CW733_RS04200	COG0612	Peptidase, M16
CW733_RS04235	COG0513	Belongs to the DEAD box helicase family
CW733_RS04245	COG1278	Cold shock
CW733_RS04260	COG0697	spore germination
CW733_RS04265	COG1278	Cold shock
CW733_RS04270	COG3239	Fatty acid desaturase
CW733_RS04275	COG1278	Cold shock
CW733_RS04280	COG3152	Membrane
CW733_RS04285	COG3152	Membrane
CW733_RS04295	COG0714	Associated with various cellular activities
CW733_RS04320	COG1278	Cold shock
CW733_RS04365	COG1733	regulation of RNA biosynthetic process
CW733_RS04370	COG0778	Nitroreductase
CW733_RS04375	COG0688	phosphatidylethanolamine metabolic process
CW733_RS04400	COG1979	alcohol dehydrogenase
CW733_RS04405	COG2130	NADP-dependent
CW733_RS04420	COG1309	transcriptional regulator
CW733_RS04425	COG2885	chlorophyll binding
CW733_RS04435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CW733_RS04440	COG0352	thiamine-phosphate diphosphorylase activity
CW733_RS04520	COG1611	Belongs to the LOG family
CW733_RS04525	COG0842	Transport permease protein
CW733_RS04530	COG0842	Transport permease protein
CW733_RS04535	COG1131	(ABC) transporter
CW733_RS04540	COG1131	(ABC) transporter
CW733_RS04615	COG1231	oxidoreductase activity
CW733_RS04625	COG3046	protein related to deoxyribodipyrimidine photolyase
CW733_RS04635	COG0415	Belongs to the DNA photolyase family
CW733_RS04640	COG0415	Belongs to the DNA photolyase family
CW733_RS04675	COG2124	cytochrome p450
CW733_RS04695	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CW733_RS04705	COG2217	Heavy metal translocating P-type atpase
CW733_RS04715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CW733_RS04725	COG0596	Alpha beta hydrolase
CW733_RS04730	COG5002	protein histidine kinase activity
CW733_RS04745	COG0129	dihydroxy-acid dehydratase activity
CW733_RS04750	COG0028	Belongs to the TPP enzyme family
CW733_RS04755	COG0440	acetolactate synthase activity
CW733_RS04765	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CW733_RS04790	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CW733_RS04820	COG1187	pseudouridine synthase activity
CW733_RS04825	COG0668	transmembrane transport
CW733_RS04855	COG1278	Cold shock
CW733_RS04870	COG0022	dehydrogenase e1 component
CW733_RS04890	COG0813	purine-nucleoside phosphorylase activity
CW733_RS04905	COG2852	Protein conserved in bacteria
CW733_RS04910	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CW733_RS04920	COG1288	antiporter activity
CW733_RS04935	COG1012	belongs to the aldehyde dehydrogenase family
CW733_RS04945	COG0101	tRNA pseudouridine synthase activity
CW733_RS04985	COG1193	negative regulation of DNA recombination
CW733_RS05005	COG3011	Protein conserved in bacteria
CW733_RS05030	COG1301	dicarboxylic acid transport
CW733_RS05045	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CW733_RS05055	COG0277	FAD linked oxidase domain protein
CW733_RS05055	COG0247	lactate metabolic process
CW733_RS05070	COG0438	transferase activity, transferring glycosyl groups
CW733_RS05075	COG1472	Belongs to the glycosyl hydrolase 3 family
CW733_RS05095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CW733_RS05100	COG0560	Phosphoserine phosphatase
CW733_RS05100	COG3830	Belongs to the UPF0237 family
CW733_RS05110	COG2181	nitrate reductase activity
CW733_RS05110	COG0247	lactate metabolic process
CW733_RS05125	COG0247	lactate metabolic process
CW733_RS05125	COG2181	nitrate reductase activity
CW733_RS05130	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CW733_RS05135	COG0860	N-Acetylmuramoyl-L-alanine amidase
CW733_RS05145	COG0251	oxidation-reduction process
CW733_RS05160	COG0205	6-phosphofructokinase activity
CW733_RS05170	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CW733_RS05185	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CW733_RS05200	COG0628	permease
CW733_RS05235	COG0183	Belongs to the thiolase family
CW733_RS05240	COG0791	NLP P60 protein
CW733_RS05275	COG0702	epimerase
CW733_RS05285	COG0302	gtp cyclohydrolase
CW733_RS05290	COG1028	Short-chain dehydrogenase reductase Sdr
CW733_RS05295	COG0386	Belongs to the glutathione peroxidase family
CW733_RS05310	COG0415	Belongs to the DNA photolyase family
CW733_RS05330	COG0542	response to heat
CW733_RS05340	COG2986	histidine ammonia-lyase
CW733_RS05345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CW733_RS05350	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CW733_RS05355	COG0460	homoserine dehydrogenase
CW733_RS05355	COG0527	aspartate kinase activity
CW733_RS05360	COG0083	homoserine kinase activity
CW733_RS05365	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CW733_RS05395	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CW733_RS05400	COG2066	Belongs to the glutaminase family
CW733_RS05410	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CW733_RS05415	COG2154	pterin-4-alpha-carbinolamine dehydratase
CW733_RS05420	COG0217	transcriptional regulatory protein
CW733_RS05435	COG2267	carboxylic ester hydrolase activity
CW733_RS05445	COG1454	alcohol dehydrogenase
CW733_RS05460	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CW733_RS05475	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CW733_RS05490	COG0742	ribosomal rna small subunit methyltransferase
CW733_RS05500	COG0798	PFAM Bile acid sodium symporter
CW733_RS05520	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CW733_RS05545	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CW733_RS05570	COG2885	chlorophyll binding
CW733_RS05570	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CW733_RS05580	COG0259	pyridoxamine-phosphate oxidase activity
CW733_RS05590	COG1234	tRNA 3'-trailer cleavage
CW733_RS05600	COG0540	Belongs to the ATCase OTCase family
CW733_RS05605	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CW733_RS05610	COG0539	negative regulation of cytoplasmic translation
CW733_RS05620	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CW733_RS05635	COG3942	CHAP domain
CW733_RS05635	COG1388	LysM domain
CW733_RS05645	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CW733_RS05695	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CW733_RS05700	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CW733_RS05705	COG0297	glycogen (starch) synthase activity
CW733_RS05710	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CW733_RS05715	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CW733_RS05725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CW733_RS05730	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CW733_RS05750	COG4974	Belongs to the 'phage' integrase family
CW733_RS05760	COG1418	mRNA catabolic process
CW733_RS05780	COG0739	heme binding
CW733_RS05810	COG1104	cysteine desulfurase activity
CW733_RS05845	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CW733_RS05865	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CW733_RS05885	COG2194	sulfuric ester hydrolase activity
CW733_RS05890	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CW733_RS05890	COG0116	Belongs to the methyltransferase superfamily
CW733_RS05910	COG1047	Peptidyl-prolyl cis-trans
CW733_RS05915	COG3617	BRO family, N-terminal domain
CW733_RS05920	COG1272	protein, Hemolysin III
CW733_RS05970	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CW733_RS05975	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CW733_RS05980	COG2339	peptidase activity
CW733_RS05985	COG0511	ligase activity, forming carbon-carbon bonds
CW733_RS05990	COG0439	Biotin carboxylase
CW733_RS05995	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CW733_RS06000	COG2095	MarC family integral membrane protein
CW733_RS06005	COG1132	(ABC) transporter
CW733_RS06020	COG2814	Major facilitator Superfamily
CW733_RS06025	COG2267	carboxylic ester hydrolase activity
CW733_RS06075	COG4585	Histidine kinase
CW733_RS06090	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CW733_RS06110	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CW733_RS06155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CW733_RS06170	COG0745	RESPONSE REGULATOR receiver
CW733_RS06175	COG5002	protein histidine kinase activity
CW733_RS06185	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CW733_RS06210	COG1012	belongs to the aldehyde dehydrogenase family
CW733_RS06215	COG2207	Transcriptional regulator
CW733_RS06220	COG1115	amino acid carrier protein
CW733_RS06230	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CW733_RS06235	COG1702	phosphate starvation-inducible protein PhoH
CW733_RS06250	COG1028	Short-chain dehydrogenase reductase Sdr
CW733_RS06260	COG0592	DNA-directed DNA polymerase activity
CW733_RS06285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CW733_RS06285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CW733_RS06290	COG0730	response to heat
CW733_RS06305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CW733_RS06310	COG0784	Response regulator, receiver
CW733_RS06310	COG2198	Histidine kinase
CW733_RS06310	COG5002	protein histidine kinase activity
CW733_RS06315	COG1331	Highly conserved protein containing a thioredoxin domain
CW733_RS06335	COG2211	Major facilitator Superfamily
CW733_RS06405	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CW733_RS06425	COG3177	Filamentation induced by cAMP protein fic
CW733_RS06430	COG0587	DNA-directed DNA polymerase activity
CW733_RS06435	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CW733_RS06500	COG0732	type I restriction modification DNA specificity domain
CW733_RS06505	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CW733_RS06515	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CW733_RS06550	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CW733_RS06570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CW733_RS06580	COG0405	Gamma-glutamyltransferase
CW733_RS06605	COG1611	Belongs to the LOG family
CW733_RS06655	COG2072	flavoprotein involved in K transport
CW733_RS06675	COG2827	Endonuclease containing a URI domain
CW733_RS06720	COG0009	L-threonylcarbamoyladenylate synthase
CW733_RS06740	COG2197	response regulator
CW733_RS06745	COG0069	glutamate synthase activity
CW733_RS06755	COG3279	Response regulator of the LytR AlgR family
CW733_RS06760	COG3275	phosphorelay sensor kinase activity
CW733_RS06790	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CW733_RS06820	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CW733_RS06825	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CW733_RS06870	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CW733_RS06880	COG0488	(ABC) transporter
CW733_RS06890	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CW733_RS06895	COG0300	oxidoreductase activity
CW733_RS06920	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CW733_RS06950	COG0542	response to heat
CW733_RS06970	COG0579	oxidoreductase
CW733_RS06975	COG3047	cAMP biosynthetic process
CW733_RS06980	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CW733_RS06995	COG0456	acetyltransferase
CW733_RS07000	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CW733_RS07005	COG4935	Belongs to the peptidase S8 family
CW733_RS07005	COG1404	Belongs to the peptidase S8 family
CW733_RS07020	COG2076	Multidrug Resistance protein
CW733_RS07035	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CW733_RS07040	COG0673	inositol 2-dehydrogenase activity
CW733_RS07045	COG1250	3-hydroxyacyl-CoA dehydrogenase
CW733_RS07055	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CW733_RS07065	COG0322	excinuclease ABC activity
CW733_RS07075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CW733_RS07080	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CW733_RS07105	COG0237	dephospho-CoA kinase activity
CW733_RS07115	COG0463	Glycosyl transferase, family 2
CW733_RS07115	COG1216	Glycosyl transferase, family 2
CW733_RS07125	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CW733_RS07130	COG0497	DNA recombination
CW733_RS07155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CW733_RS07170	COG0737	Belongs to the 5'-nucleotidase family
CW733_RS07190	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CW733_RS07215	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CW733_RS07215	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CW733_RS07220	COG1011	Hydrolase
CW733_RS07230	COG1739	Uncharacterized protein family UPF0029
CW733_RS07235	COG0824	Thioesterase
CW733_RS07240	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CW733_RS07245	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CW733_RS07255	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CW733_RS07270	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CW733_RS07280	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CW733_RS07285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CW733_RS07310	COG0456	acetyltransferase
CW733_RS07335	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CW733_RS07345	COG1136	(ABC) transporter
CW733_RS07370	COG0463	Glycosyl transferase, family 2
CW733_RS07380	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CW733_RS07400	COG1234	tRNA 3'-trailer cleavage
CW733_RS07415	COG0336	Belongs to the RNA methyltransferase TrmD family
CW733_RS07425	COG0335	large ribosomal subunit rRNA binding
CW733_RS07450	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CW733_RS07490	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CW733_RS07495	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CW733_RS07500	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CW733_RS07505	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CW733_RS07510	COG0561	phosphatase activity
CW733_RS07515	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CW733_RS07535	COG0305	Participates in initiation and elongation during chromosome replication
CW733_RS07540	COG0825	malonyl-CoA metabolic process
CW733_RS07555	COG0343	queuine tRNA-ribosyltransferase activity
CW733_RS07560	COG3959	Transketolase, thiamine diphosphate binding domain
CW733_RS07565	COG3958	Transketolase
CW733_RS07585	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CW733_RS07590	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CW733_RS07635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CW733_RS07665	COG0714	Associated with various cellular activities
CW733_RS07670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CW733_RS07695	COG0517	IMP dehydrogenase activity
CW733_RS07695	COG0516	GMP reductase activity
CW733_RS07710	COG1730	sister chromatid segregation
CW733_RS07725	COG0167	dihydroorotate dehydrogenase activity
CW733_RS07730	COG2195	Cleaves the N-terminal amino acid of tripeptides
CW733_RS07750	COG1271	oxidase subunit
CW733_RS07755	COG1294	oxidase, subunit
CW733_RS07785	COG1609	Transcriptional regulator
CW733_RS07790	COG1862	Preprotein translocase
CW733_RS07800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CW733_RS07810	COG1132	(ABC) transporter
CW733_RS07830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CW733_RS07835	COG0300	oxidoreductase activity
CW733_RS07850	COG2318	DinB family
CW733_RS07860	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CW733_RS07870	COG0514	ATP-dependent DNA helicase (RecQ)
CW733_RS07875	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CW733_RS07875	COG0517	IMP dehydrogenase activity
CW733_RS07880	COG0805	protein transport
CW733_RS07890	COG1137	ATPase activity
CW733_RS07900	COG0861	Integral membrane protein TerC family
CW733_RS07905	COG1183	phosphatidylcholine synthase activity
CW733_RS07925	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CW733_RS07960	COG0297	glycogen (starch) synthase activity
CW733_RS07960	COG0438	transferase activity, transferring glycosyl groups
CW733_RS07965	COG0463	Glycosyl transferase, family 2
CW733_RS08000	COG2089	acid synthase
CW733_RS08010	COG1083	cytidylyl-transferase
CW733_RS08010	COG2755	lipolytic protein G-D-S-L family
CW733_RS08030	COG2226	methyltransferase
CW733_RS08050	COG1216	Glycosyl transferase, family 2
CW733_RS08060	COG1216	Glycosyl transferase, family 2
CW733_RS08060	COG1442	glycosyl transferase family 8
CW733_RS08085	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CW733_RS08095	COG0489	protein tyrosine kinase activity
CW733_RS08105	COG0488	(ABC) transporter
CW733_RS08125	COG0653	protein targeting
CW733_RS08160	COG1595	DNA-templated transcription, initiation
CW733_RS08175	COG0546	phosphoglycolate phosphatase activity
CW733_RS08200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CW733_RS08205	COG0463	Glycosyl transferase, family 2
CW733_RS08220	COG0671	phosphoesterase, PA-phosphatase related
CW733_RS08235	COG0534	Mate efflux family protein
CW733_RS08250	COG0482	sulfurtransferase activity
CW733_RS08255	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CW733_RS08265	COG0706	membrane insertase activity
CW733_RS08270	COG0504	CTP synthase activity
CW733_RS08280	COG3530	Putative quorum-sensing-regulated virulence factor
CW733_RS08290	COG0791	NLP P60 protein
CW733_RS08290	COG1388	LysM domain
CW733_RS08295	COG0519	Catalyzes the synthesis of GMP from XMP
CW733_RS08295	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CW733_RS08300	COG0076	glutamate decarboxylase activity
CW733_RS08305	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
CW733_RS08330	COG3022	response to hydroperoxide
CW733_RS08335	COG0564	pseudouridine synthase activity
CW733_RS08340	COG2815	serine threonine protein kinase
CW733_RS08340	COG0515	serine threonine protein kinase
CW733_RS08345	COG1181	Belongs to the D-alanine--D-alanine ligase family
CW733_RS08350	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CW733_RS08355	COG2198	Histidine kinase
CW733_RS08355	COG2205	protein histidine kinase activity
CW733_RS08355	COG0784	Response regulator, receiver
CW733_RS08360	COG0659	secondary active sulfate transmembrane transporter activity
CW733_RS08380	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CW733_RS08395	COG0799	negative regulation of ribosome biogenesis
CW733_RS08400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CW733_RS08410	COG4589	Belongs to the CDS family
CW733_RS08415	COG0688	phosphatidylethanolamine metabolic process
CW733_RS08425	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
CW733_RS08430	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CW733_RS08435	COG1127	ABC transporter
CW733_RS08455	COG1733	regulation of RNA biosynthetic process
CW733_RS08475	COG0018	arginyl-trna synthetase
CW733_RS08480	COG4251	negative regulation of phosphorylation
CW733_RS08520	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CW733_RS08535	COG0552	protein localization to endoplasmic reticulum
CW733_RS08545	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CW733_RS08550	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CW733_RS08555	COG1058	Belongs to the CinA family
CW733_RS08555	COG1546	Belongs to the CinA family
CW733_RS08565	COG0179	Fumarylacetoacetate (FAA) hydrolase
CW733_RS08595	COG0508	dehydrogenase complex catalyzes the overall conversion of
CW733_RS08605	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CW733_RS08610	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CW733_RS08630	COG0326	Molecular chaperone. Has ATPase activity
CW733_RS08660	COG4585	Histidine kinase
CW733_RS08700	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CW733_RS08715	COG2814	Major facilitator Superfamily
CW733_RS08745	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CW733_RS08765	COG1703	isobutyryl-CoA mutase activity
CW733_RS08765	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CW733_RS08765	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CW733_RS08770	COG0788	formyltetrahydrofolate deformylase activity
CW733_RS08780	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CW733_RS08785	COG0284	orotidine-5'-phosphate decarboxylase activity
CW733_RS08790	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CW733_RS08810	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CW733_RS08865	COG0174	glutamine synthetase
CW733_RS08880	COG0442	prolyl-tRNA aminoacylation
CW733_RS08890	COG0268	Binds directly to 16S ribosomal RNA
CW733_RS08915	COG0101	tRNA pseudouridine synthase activity
CW733_RS08920	COG1132	(ABC) transporter
CW733_RS08945	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CW733_RS08965	COG0149	triose-phosphate isomerase activity
CW733_RS08970	COG2264	protein methyltransferase activity
CW733_RS08975	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CW733_RS09020	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CW733_RS09055	COG2356	endonuclease I
CW733_RS09075	COG0302	gtp cyclohydrolase
CW733_RS09080	COG0215	cysteine-tRNA ligase activity
CW733_RS09085	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CW733_RS09090	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CW733_RS09110	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CW733_RS09130	COG0187	DNA topoisomerase II activity
CW733_RS09145	COG0367	asparagine synthase
CW733_RS09150	COG0602	queuosine metabolic process
CW733_RS09155	COG0433	COG0433 Predicted ATPase
CW733_RS09165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CW733_RS09195	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CW733_RS09200	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CW733_RS09225	COG2234	aminopeptidase activity
CW733_RS09255	COG0148	phosphopyruvate hydratase activity
CW733_RS09260	COG0505	Belongs to the CarA family
CW733_RS09275	COG0203	ribosomal protein L17
CW733_RS09280	COG0202	RNA polymerase activity
CW733_RS09285	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CW733_RS09290	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CW733_RS09295	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CW733_RS09300	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CW733_RS09305	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CW733_RS09310	COG0201	protein transport
CW733_RS09315	COG0200	Binds to the 23S rRNA
CW733_RS09320	COG1841	ribosomal large subunit assembly
CW733_RS09325	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CW733_RS09330	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CW733_RS09335	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CW733_RS09340	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CW733_RS09345	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CW733_RS09350	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CW733_RS09355	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CW733_RS09360	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CW733_RS09365	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CW733_RS09370	COG0255	Belongs to the universal ribosomal protein uL29 family
CW733_RS09375	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CW733_RS09380	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CW733_RS09385	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CW733_RS09390	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CW733_RS09395	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CW733_RS09400	COG0089	rRNA binding
CW733_RS09405	COG0088	Forms part of the polypeptide exit tunnel
CW733_RS09410	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CW733_RS09415	COG0051	transcription antitermination factor activity, RNA binding
CW733_RS09420	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CW733_RS09425	COG0049	tRNA binding
CW733_RS09430	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CW733_RS09440	COG1629	transport
CW733_RS09465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CW733_RS09475	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CW733_RS09485	COG1011	Hydrolase
CW733_RS09495	COG2003	Belongs to the UPF0758 family
CW733_RS09525	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CW733_RS09535	COG1629	transport
CW733_RS09550	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CW733_RS09555	COG1404	Belongs to the peptidase S8 family
CW733_RS09585	COG1028	Short-chain dehydrogenase reductase Sdr
CW733_RS09605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CW733_RS09615	COG3844	kynureninase activity
CW733_RS09645	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CW733_RS09650	COG1663	tetraacyldisaccharide 4'-kinase activity
CW733_RS09655	COG0784	Response regulator, receiver
CW733_RS09655	COG2205	protein histidine kinase activity
CW733_RS09660	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CW733_RS09665	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CW733_RS09675	COG1216	Glycosyl transferase, family 2
CW733_RS09695	COG1595	DNA-templated transcription, initiation
CW733_RS09700	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CW733_RS09705	COG0436	Aminotransferase
CW733_RS09720	COG0525	valine-tRNA ligase activity
CW733_RS09725	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CW733_RS09730	COG0357	Ribosomal RNA small subunit methyltransferase G
CW733_RS09735	COG3239	Fatty acid desaturase
CW733_RS09740	COG0436	Aminotransferase
CW733_RS09760	COG0569	domain protein
CW733_RS09765	COG2226	methyltransferase
CW733_RS09785	COG0191	fructose-bisphosphate aldolase activity
CW733_RS09790	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CW733_RS09805	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CW733_RS09810	COG1185	polyribonucleotide nucleotidyltransferase activity
CW733_RS09820	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CW733_RS09830	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CW733_RS09850	COG1610	YqeY-like protein
CW733_RS09855	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CW733_RS09870	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CW733_RS09875	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CW733_RS09880	COG0772	Belongs to the SEDS family
CW733_RS09885	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CW733_RS09890	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CW733_RS09895	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CW733_RS09900	COG0768	penicillin binding
CW733_RS09910	COG0275	rRNA processing
CW733_RS09915	COG2001	Belongs to the MraZ family
CW733_RS09925	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CW733_RS09930	COG0564	pseudouridine synthase activity
CW733_RS09940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CW733_RS09950	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CW733_RS09960	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CW733_RS09965	COG0791	NLP P60 protein
CW733_RS09985	COG3104	oligopeptide transport
CW733_RS09990	COG0823	Involved in the tonB-independent uptake of proteins
CW733_RS09990	COG1506	peptidase
CW733_RS10010	COG1253	flavin adenine dinucleotide binding
CW733_RS10035	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CW733_RS10045	COG2201	protein-glutamate methylesterase activity
CW733_RS10075	COG3604	Transcriptional regulator
CW733_RS10100	COG0784	Response regulator, receiver
CW733_RS10105	COG2202	Pas domain
CW733_RS10105	COG2205	protein histidine kinase activity
CW733_RS10115	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CW733_RS10120	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CW733_RS10125	COG0066	3-isopropylmalate dehydratase activity
CW733_RS10135	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CW733_RS10140	COG0004	ammonium transporteR
CW733_RS10155	COG0070	glutamate synthase
CW733_RS10155	COG0069	glutamate synthase activity
CW733_RS10155	COG0067	glutamate synthase
CW733_RS10165	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CW733_RS10170	COG0165	Argininosuccinate lyase
CW733_RS10180	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CW733_RS10190	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CW733_RS10200	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CW733_RS10205	COG0137	argininosuccinate synthase activity
CW733_RS10215	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CW733_RS10220	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CW733_RS10230	COG0028	Belongs to the TPP enzyme family
CW733_RS10235	COG0129	dihydroxy-acid dehydratase activity
CW733_RS10240	COG0590	tRNA wobble adenosine to inosine editing
CW733_RS10250	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CW733_RS10270	COG3608	succinylglutamate desuccinylase aspartoacylase
CW733_RS10270	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CW733_RS10295	COG1054	Belongs to the UPF0176 family
CW733_RS10305	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CW733_RS10310	COG2226	methyltransferase
CW733_RS10355	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CW733_RS10375	COG1215	transferase activity, transferring glycosyl groups
CW733_RS10395	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CW733_RS10395	COG3153	acetyltransferase
CW733_RS10400	COG1899	peptidyl-lysine modification to peptidyl-hypusine
CW733_RS10405	COG0010	Belongs to the arginase family
CW733_RS10410	COG1166	arginine decarboxylase activity
CW733_RS10415	COG1187	pseudouridine synthase activity
CW733_RS10440	COG1309	transcriptional regulator
CW733_RS10450	COG2081	HI0933 family
CW733_RS10515	COG0006	proline dipeptidase activity
CW733_RS10520	COG0006	proline dipeptidase activity
CW733_RS10525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CW733_RS10530	COG3938	Belongs to the proline racemase family
CW733_RS10540	COG3813	Protein conserved in bacteria
CW733_RS10545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CW733_RS10555	COG2824	Alkylphosphonate utilization operon protein PhnA
CW733_RS10560	COG1482	cell wall glycoprotein biosynthetic process
CW733_RS10570	COG0745	RESPONSE REGULATOR receiver
CW733_RS10650	COG2340	Cysteine-rich secretory protein family
CW733_RS10655	COG3279	Response regulator of the LytR AlgR family
CW733_RS10665	COG4251	negative regulation of phosphorylation
CW733_RS10675	COG4251	negative regulation of phosphorylation
CW733_RS10685	COG0784	Response regulator, receiver
CW733_RS10715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CW733_RS10725	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CW733_RS10825	COG0740	serine-type endopeptidase activity
CW733_RS10845	COG0228	four-way junction DNA binding
CW733_RS10850	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CW733_RS10855	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CW733_RS10870	COG0633	Ferredoxin
CW733_RS10875	COG0492	ferredoxin-NADP+ reductase activity
CW733_RS10885	COG0489	protein tyrosine kinase activity
CW733_RS10900	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CW733_RS10905	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CW733_RS10910	COG5002	protein histidine kinase activity
CW733_RS10915	COG0745	RESPONSE REGULATOR receiver
CW733_RS10940	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CW733_RS10945	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CW733_RS10955	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CW733_RS10960	COG0463	Glycosyl transferase, family 2
CW733_RS10975	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CW733_RS10980	COG2363	Small membrane protein
CW733_RS10990	COG1522	sequence-specific DNA binding
CW733_RS11025	COG0508	dehydrogenase complex catalyzes the overall conversion of
CW733_RS11035	COG0567	Dehydrogenase, E1 component
CW733_RS11050	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CW733_RS11055	COG4263	nitrous-oxide reductase activity
CW733_RS11130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CW733_RS11135	COG1629	transport
CW733_RS11140	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CW733_RS11180	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CW733_RS11195	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CW733_RS11200	COG4771	TonB-dependent receptor
CW733_RS11230	COG1360	Flagellar Motor Protein
CW733_RS11240	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CW733_RS11245	COG1328	CTP reductase activity
CW733_RS11245	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CW733_RS11260	COG3275	phosphorelay sensor kinase activity
CW733_RS11270	COG2095	MarC family integral membrane protein
CW733_RS11285	COG3409	Peptidoglycan-binding domain 1 protein
CW733_RS11285	COG0793	Belongs to the peptidase S41A family
CW733_RS11305	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CW733_RS11310	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CW733_RS11315	COG0193	aminoacyl-tRNA hydrolase activity
CW733_RS11325	COG0196	riboflavin kinase activity
CW733_RS11335	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CW733_RS11355	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CW733_RS11360	COG2239	Acts as a magnesium transporter
CW733_RS11365	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CW733_RS11405	COG0527	aspartate kinase activity
CW733_RS11415	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CW733_RS11435	COG0784	Response regulator, receiver
CW733_RS11435	COG2205	protein histidine kinase activity
CW733_RS11455	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CW733_RS11530	COG0784	Response regulator, receiver
CW733_RS11530	COG2205	protein histidine kinase activity
CW733_RS11575	COG1194	a g-specific adenine glycosylase
CW733_RS11580	COG0776	regulation of translation
CW733_RS11585	COG1530	ribonuclease E activity
CW733_RS11605	COG0667	Aldo Keto reductase
CW733_RS11610	COG1360	Flagellar Motor Protein
CW733_RS11615	COG0708	Exodeoxyribonuclease III
CW733_RS11650	COG0423	glycine-tRNA ligase activity
CW733_RS11680	COG0436	Aminotransferase
CW733_RS11685	COG4717	serine-type aminopeptidase activity
CW733_RS11690	COG0456	acetyltransferase
CW733_RS11695	COG3279	Response regulator of the LytR AlgR family
CW733_RS11700	COG3275	phosphorelay sensor kinase activity
CW733_RS11715	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CW733_RS11725	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CW733_RS11730	COG1053	succinate dehydrogenase
CW733_RS11745	COG0006	proline dipeptidase activity
CW733_RS11760	COG0527	aspartate kinase activity
CW733_RS11830	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CW733_RS11850	COG1858	cytochrome C peroxidase
CW733_RS11855	COG0316	Belongs to the HesB IscA family
CW733_RS11860	COG0719	Fe-S assembly protein
CW733_RS11870	COG0396	ATPase activity
CW733_RS11875	COG0719	Fe-S assembly protein
CW733_RS11880	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CW733_RS11890	COG2166	iron-sulfur cluster assembly
CW733_RS11895	COG2151	metal-sulfur cluster biosynthetic enzyme
CW733_RS11925	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CW733_RS11935	COG0629	single-stranded DNA binding
CW733_RS11970	COG3590	peptidase
CW733_RS11990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CW733_RS11995	COG0180	Tryptophanyl-tRNA synthetase
CW733_RS12005	COG0484	heat shock protein binding
CW733_RS12025	COG1418	mRNA catabolic process
CW733_RS12040	COG1024	Enoyl-CoA hydratase
CW733_RS12055	COG1981	membrane
CW733_RS12060	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CW733_RS12080	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CW733_RS12085	COG0181	hydroxymethylbilane synthase activity
CW733_RS12090	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CW733_RS12110	COG0408	coproporphyrinogen oxidase activity
CW733_RS12115	COG3012	SEC-C Motif Domain Protein
CW733_RS12120	COG0113	porphobilinogen synthase activity
CW733_RS12125	COG1253	flavin adenine dinucleotide binding
CW733_RS12130	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CW733_RS12180	COG4206	TonB-dependent receptor
CW733_RS12180	COG4206	TonB-dependent receptor
CW733_RS12190	COG0288	reversible hydration of carbon dioxide
CW733_RS12195	COG0659	secondary active sulfate transmembrane transporter activity
CW733_RS12215	COG0659	secondary active sulfate transmembrane transporter activity
CW733_RS12240	COG2304	oxidoreductase activity
CW733_RS12245	COG2304	oxidoreductase activity
CW733_RS12260	COG0714	Associated with various cellular activities
CW733_RS12265	COG4989	oxidoreductase activity
CW733_RS12270	COG4221	oxidoreductase activity
CW733_RS12300	COG1012	belongs to the aldehyde dehydrogenase family
CW733_RS12305	COG1446	asparaginase
CW733_RS12320	COG2329	Antibiotic biosynthesis monooxygenase
CW733_RS12330	COG4953	penicillin-binding protein 1C
CW733_RS12365	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CW733_RS12380	COG1774	PSP1 C-terminal conserved region
CW733_RS12390	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CW733_RS12420	COG3341	Caulimovirus viroplasmin
CW733_RS12420	COG0328	RNA-DNA hybrid ribonuclease activity
CW733_RS12435	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CW733_RS12440	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CW733_RS12445	COG0571	ribonuclease III activity
CW733_RS12465	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CW733_RS12470	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CW733_RS12475	COG1121	(ABC) transporter
CW733_RS12480	COG0803	Belongs to the bacterial solute-binding protein 9 family
CW733_RS12515	COG1999	signal sequence binding
CW733_RS12520	COG0750	zinc metalloprotease
CW733_RS12540	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CW733_RS12540	COG0758	DNA mediated transformation
CW733_RS12550	COG1607	acyl-coa hydrolase
CW733_RS12570	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CW733_RS12575	COG0756	dUTP diphosphatase activity
CW733_RS12600	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CW733_RS12605	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CW733_RS12610	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CW733_RS12615	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CW733_RS12620	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CW733_RS12625	COG0356	it plays a direct role in the translocation of protons across the membrane
CW733_RS12660	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CW733_RS12665	COG0859	PFAM glycosyl transferase family 9
CW733_RS12675	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CW733_RS12700	COG1215	transferase activity, transferring glycosyl groups
CW733_RS12715	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CW733_RS12725	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CW733_RS12735	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CW733_RS12750	COG0438	transferase activity, transferring glycosyl groups
CW733_RS12800	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CW733_RS12850	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CW733_RS12860	COG0791	NLP P60 protein
CW733_RS12860	COG1388	LysM domain
CW733_RS12865	COG0126	phosphoglycerate kinase activity
CW733_RS12875	COG0470	DNA polymerase III
CW733_RS12895	COG0445	tRNA wobble uridine modification
CW733_RS12900	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CW733_RS12910	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CW733_RS12950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CW733_RS12985	COG0557	exoribonuclease II activity
CW733_RS12990	COG0698	ribose 5-phosphate isomerase
CW733_RS13000	COG2153	protein acetylation
CW733_RS13010	COG0793	Belongs to the peptidase S41A family
CW733_RS13015	COG0594	ribonuclease P activity
CW733_RS13030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CW733_RS13035	COG0659	secondary active sulfate transmembrane transporter activity
CW733_RS13045	COG3263	regulation of cellular component size
CW733_RS13065	COG3275	phosphorelay sensor kinase activity
CW733_RS13075	COG0481	GTPase activity
CW733_RS13090	COG2234	aminopeptidase activity
CW733_RS13100	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CW733_RS13105	COG4591	ABC-type transport system involved in lipoprotein release permease component
CW733_RS13110	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CW733_RS13115	COG0346	lactoylglutathione lyase activity
CW733_RS13125	COG1228	amidohydrolase
CW733_RS13140	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CW733_RS13150	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CW733_RS13155	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CW733_RS13160	COG0511	ligase activity, forming carbon-carbon bonds
CW733_RS13165	COG0439	Biotin carboxylase
CW733_RS13175	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CW733_RS13185	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CW733_RS13195	COG3424	synthase
CW733_RS13200	COG1028	Short-chain dehydrogenase reductase Sdr
CW733_RS13215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CW733_RS13220	COG0736	holo-[acyl-carrier-protein] synthase activity
CW733_RS13225	COG3842	ATPase activity
CW733_RS13230	COG1505	serine-type exopeptidase activity
CW733_RS13245	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CW733_RS13250	COG1970	mechanosensitive ion channel activity
CW733_RS13255	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CW733_RS13260	COG1435	thymidine kinase activity
CW733_RS13280	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CW733_RS13285	COG1573	uracil-dna glycosylase
CW733_RS13300	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CW733_RS13300	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CW733_RS13325	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CW733_RS13330	COG0720	synthase
CW733_RS13335	COG0534	Mate efflux family protein
CW733_RS13350	COG0210	DNA helicase
CW733_RS13360	COG0156	8-amino-7-oxononanoate synthase activity
CW733_RS13365	COG1074	ATP-dependent DNA helicase activity
CW733_RS13385	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CW733_RS13395	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CW733_RS13400	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CW733_RS13410	COG1652	LysM domain
CW733_RS13420	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CW733_RS13425	COG0194	GDP metabolic process
CW733_RS13430	COG1561	YicC-like family, N-terminal region
CW733_RS13460	COG0626	cystathionine gamma-synthase activity
CW733_RS13470	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CW733_RS13480	COG1381	Involved in DNA repair and RecF pathway recombination
CW733_RS13520	COG2267	carboxylic ester hydrolase activity
CW733_RS13530	COG2268	Band 7 protein
CW733_RS13565	COG3655	Transcriptional regulator
CW733_RS13570	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CW733_RS13575	COG3647	Membrane
CW733_RS13580	COG2954	triphosphatase activity
CW733_RS13585	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CW733_RS13620	COG4771	TonB-dependent receptor
CW733_RS13625	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CW733_RS13635	COG0297	glycogen (starch) synthase activity
CW733_RS13640	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CW733_RS13645	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CW733_RS13660	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CW733_RS13670	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CW733_RS13690	COG4771	TonB-dependent receptor
CW733_RS13695	COG0166	Belongs to the GPI family
CW733_RS13705	COG3483	tryptophan 2,3-dioxygenase activity
CW733_RS13715	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CW733_RS13720	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CW733_RS13725	COG1752	Esterase of the alpha-beta hydrolase superfamily
CW733_RS13730	COG0322	excinuclease ABC activity
CW733_RS13735	COG4067	protein conserved in archaea
CW733_RS13735	COG0189	ligase activity
CW733_RS13740	COG0189	ligase activity
CW733_RS13750	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CW733_RS13755	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CW733_RS13800	COG2885	chlorophyll binding
CW733_RS13815	COG2972	Histidine kinase
CW733_RS13815	COG0745	RESPONSE REGULATOR receiver
CW733_RS13850	COG0529	Catalyzes the synthesis of activated sulfate
CW733_RS13855	COG0175	sulfate reduction
CW733_RS13890	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CW733_RS13890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CW733_RS13895	COG1619	proteins homologs of microcin C7 resistance protein MccF
CW733_RS13900	COG0792	nuclease activity
CW733_RS13910	COG2217	Heavy metal translocating P-type atpase
CW733_RS13925	COG0612	Peptidase, M16
CW733_RS13930	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CW733_RS13935	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CW733_RS13950	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CW733_RS13960	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
CW733_RS13970	COG3201	nicotinamide mononucleotide transporter
CW733_RS13985	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CW733_RS14000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CW733_RS14015	COG3852	Histidine kinase
CW733_RS14020	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CW733_RS14030	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CW733_RS14035	COG0519	Catalyzes the synthesis of GMP from XMP
CW733_RS14050	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CW733_RS14055	COG1968	undecaprenyl-diphosphatase activity
CW733_RS14065	COG2177	Part of the ABC transporter FtsEX involved in
CW733_RS14070	COG0495	leucyl-tRNA aminoacylation
CW733_RS14105	COG2197	response regulator
CW733_RS14160	COG0084	hydrolase, TatD family'
CW733_RS14165	COG0252	asparaginase activity
CW733_RS14170	COG0811	peptide transport
CW733_RS14205	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CW733_RS14215	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CW733_RS14235	COG1289	transmembrane transporter activity
CW733_RS14250	COG0513	Belongs to the DEAD box helicase family
CW733_RS14265	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CW733_RS14275	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CW733_RS14305	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CW733_RS14325	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CW733_RS14340	COG0017	Asparaginyl-tRNA synthetase
CW733_RS14355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CW733_RS14360	COG0233	cytoplasmic translational termination
CW733_RS14365	COG0528	UMP kinase activity
CW733_RS14370	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CW733_RS14375	COG0052	Belongs to the universal ribosomal protein uS2 family
CW733_RS14380	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CW733_RS14385	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CW733_RS14390	COG1032	radical SAM domain protein
CW733_RS14395	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CW733_RS14415	COG3177	Filamentation induced by cAMP protein fic
CW733_RS14425	COG1061	Type III restriction enzyme res subunit
CW733_RS14430	COG2816	NAD+ diphosphatase activity
CW733_RS14435	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CW733_RS14435	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CW733_RS14440	COG1446	asparaginase
CW733_RS14445	COG2827	Endonuclease containing a URI domain
CW733_RS14455	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CW733_RS14455	COG0189	ligase activity
CW733_RS14460	COG1446	asparaginase
CW733_RS14470	COG3537	Alpha-1,2-mannosidase
CW733_RS14480	COG3118	belongs to the thioredoxin family
CW733_RS14500	COG0589	response to stress
CW733_RS14505	COG0779	Required for maturation of 30S ribosomal subunits
CW733_RS14510	COG0195	Participates in both transcription termination and antitermination
CW733_RS14515	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CW733_RS14530	COG0437	4 iron, 4 sulfur cluster binding
CW733_RS14555	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CW733_RS14560	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CW733_RS14565	COG2255	four-way junction helicase activity
CW733_RS14570	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CW733_RS14580	COG0281	malic enzyme
CW733_RS14580	COG0280	phosphate acetyltransferase
CW733_RS14585	COG0632	four-way junction helicase activity
CW733_RS14595	COG0509	glycine decarboxylation via glycine cleavage system
CW733_RS14620	COG0109	protoheme IX farnesyltransferase activity
CW733_RS14625	COG1845	cytochrome c oxidase, subunit III
CW733_RS14645	COG1999	signal sequence binding
CW733_RS14650	COG2322	membrane
CW733_RS14660	COG1136	(ABC) transporter
CW733_RS14665	COG0577	efflux transmembrane transporter activity
CW733_RS14665	COG1136	(ABC) transporter
CW733_RS14670	COG1136	(ABC) transporter
CW733_RS14670	COG0577	efflux transmembrane transporter activity
CW733_RS14675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CW733_RS14685	COG1214	PFAM Peptidase M22, glycoprotease
CW733_RS14690	COG0668	transmembrane transport
CW733_RS14700	COG1331	Highly conserved protein containing a thioredoxin domain
CW733_RS14735	COG3275	phosphorelay sensor kinase activity
CW733_RS14745	COG3279	Response regulator of the LytR AlgR family
CW733_RS14750	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CW733_RS14770	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CW733_RS14790	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CW733_RS14800	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CW733_RS14815	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CW733_RS14820	COG0596	Alpha beta hydrolase
CW733_RS14830	COG0544	peptidyl-prolyl cis-trans isomerase activity
CW733_RS14840	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CW733_RS14860	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CW733_RS14870	COG1428	Deoxynucleoside kinase
CW733_RS14880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CW733_RS14885	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CW733_RS14905	COG1519	Transferase
CW733_RS14905	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CW733_RS14915	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CW733_RS14925	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CW733_RS14930	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CW733_RS14935	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CW733_RS14945	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CW733_RS14960	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CW733_RS14965	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CW733_RS14975	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CW733_RS14985	COG0022	dehydrogenase e1 component
CW733_RS14985	COG0508	dehydrogenase complex catalyzes the overall conversion of
CW733_RS15005	COG1595	DNA-templated transcription, initiation
CW733_RS15030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CW733_RS15060	COG2967	ApaG domain
CW733_RS15065	COG1131	(ABC) transporter
CW733_RS15085	COG1805	sodium ion transport
CW733_RS15090	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CW733_RS15100	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CW733_RS15120	COG1477	protein flavinylation
CW733_RS15145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CW733_RS15150	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CW733_RS15150	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CW733_RS15190	COG2226	methyltransferase
CW733_RS15200	COG1510	regulation of RNA biosynthetic process
CW733_RS15215	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CW733_RS15220	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CW733_RS15225	COG0563	adenylate kinase activity
CW733_RS15235	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CW733_RS15260	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CW733_RS15270	COG1160	GTP binding
CW733_RS15315	COG4942	peptidase
CW733_RS15320	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CW733_RS15340	COG1309	transcriptional regulator
CW733_RS15345	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CW733_RS15350	COG3396	Phenylacetate-CoA oxygenase
CW733_RS15355	COG3460	Phenylacetate-CoA oxygenase
CW733_RS15360	COG3396	Phenylacetate-CoA oxygenase
CW733_RS15365	COG2151	metal-sulfur cluster biosynthetic enzyme
CW733_RS15370	COG1024	Enoyl-CoA hydratase
CW733_RS15375	COG1250	3-hydroxyacyl-CoA dehydrogenase
CW733_RS15385	COG0183	Belongs to the thiolase family
CW733_RS15390	COG1012	belongs to the aldehyde dehydrogenase family
CW733_RS15390	COG2030	dehydratase
CW733_RS15410	COG0508	dehydrogenase complex catalyzes the overall conversion of
CW733_RS15415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CW733_RS15420	COG0022	dehydrogenase e1 component
CW733_RS15425	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CW733_RS15440	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CW733_RS15445	COG2197	response regulator
CW733_RS15450	COG0358	DNA primase activity
CW733_RS15495	COG0772	Belongs to the SEDS family
CW733_RS15500	COG0768	penicillin binding
CW733_RS15515	COG1077	Cell shape determining protein MreB Mrl
CW733_RS15520	COG0138	bifunctional purine biosynthesis protein purh
CW733_RS15525	COG1956	GAF domain-containing protein
CW733_RS15560	COG3275	phosphorelay sensor kinase activity
CW733_RS15590	COG2363	Small membrane protein
CW733_RS15595	COG2226	methyltransferase
CW733_RS15610	COG0427	acetyl-CoA hydrolase
CW733_RS15625	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CW733_RS15630	COG0501	Belongs to the peptidase M48B family
CW733_RS15655	COG3340	Belongs to the peptidase S51 family
CW733_RS15680	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CW733_RS15690	COG1428	Deoxynucleoside kinase
CW733_RS15715	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CW733_RS15730	COG0527	aspartate kinase activity
CW733_RS15730	COG0460	homoserine dehydrogenase
CW733_RS15745	COG1410	methionine synthase
CW733_RS15745	COG0646	methionine synthase
CW733_RS15750	COG2329	Antibiotic biosynthesis monooxygenase
CW733_RS15760	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CW733_RS15765	COG1959	2 iron, 2 sulfur cluster binding
CW733_RS15775	COG0175	sulfate reduction
CW733_RS15780	COG0175	sulfate reduction
CW733_RS15785	COG2895	sulfate adenylyltransferase (ATP) activity
CW733_RS15790	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CW733_RS15800	COG1648	precorrin-2 dehydrogenase activity
CW733_RS15800	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CW733_RS15805	COG0492	ferredoxin-NADP+ reductase activity
CW733_RS15810	COG0633	Ferredoxin
CW733_RS15815	COG1045	serine acetyltransferase
CW733_RS15865	COG0688	phosphatidylethanolamine metabolic process
CW733_RS15895	COG1605	Chorismate mutase
CW733_RS15895	COG0077	Prephenate dehydratase
CW733_RS15900	COG0436	Aminotransferase
CW733_RS15905	COG0287	Prephenate dehydrogenase
CW733_RS15910	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CW733_RS15920	COG1162	GTPase activity
CW733_RS15925	COG1490	D-aminoacyl-tRNA deacylase activity
CW733_RS15940	COG1988	membrane-bound metal-dependent
CW733_RS15950	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CW733_RS15955	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CW733_RS15970	COG5492	domain, Protein
CW733_RS15970	COG4932	domain protein
CW733_RS15980	COG0459	protein refolding
CW733_RS15985	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CW733_RS16005	COG2204	response regulator
CW733_RS16010	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CW733_RS16030	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CW733_RS16050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CW733_RS16060	COG0488	(ABC) transporter
CW733_RS16100	COG0366	Alpha amylase catalytic
CW733_RS16100	COG1874	Beta-galactosidase
CW733_RS16110	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CW733_RS16115	COG4206	TonB-dependent receptor
CW733_RS16115	COG1629	transport
CW733_RS16125	COG2190	(PTS) system
CW733_RS16125	COG2211	Major facilitator Superfamily
CW733_RS16130	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CW733_RS16135	COG1554	hydrolase, family 65, central catalytic
CW733_RS16140	COG0366	Alpha amylase catalytic
CW733_RS16145	COG1501	Belongs to the glycosyl hydrolase 31 family
CW733_RS16150	COG0366	Alpha amylase catalytic
CW733_RS16180	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CW733_RS16190	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CW733_RS16195	COG1705	Flagellar rod assembly protein muramidase FlgJ
CW733_RS16195	COG1388	LysM domain
CW733_RS16200	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CW733_RS16220	COG4682	membrane
CW733_RS16260	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CW733_RS16265	COG0401	homolog of Blt101
CW733_RS16270	COG0321	lipoyl(octanoyl) transferase activity
CW733_RS16295	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CW733_RS16340	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids