locus-tag	class	description
A3778_RS00020	COG0542	response to heat
A3778_RS00030	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3778_RS00040	COG2814	Major facilitator Superfamily
A3778_RS00050	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A3778_RS00055	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A3778_RS00065	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A3778_RS00085	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A3778_RS00090	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A3778_RS00100	COG0151	Belongs to the GarS family
A3778_RS00105	COG3682	Transcriptional regulator
A3778_RS00110	COG2217	Heavy metal translocating P-type atpase
A3778_RS00120	COG0642	Histidine kinase
A3778_RS00125	COG0745	RESPONSE REGULATOR receiver
A3778_RS00130	COG1136	(ABC) transporter
A3778_RS00145	COG1234	tRNA 3'-trailer cleavage
A3778_RS00150	COG1393	Belongs to the ArsC family
A3778_RS00170	COG0167	dihydroorotate dehydrogenase activity
A3778_RS00195	COG0018	arginyl-trna synthetase
A3778_RS00200	COG1438	arginine binding
A3778_RS00205	COG0564	pseudouridine synthase activity
A3778_RS00210	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A3778_RS00225	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A3778_RS00235	COG0537	adenosine 5'-monophosphoramidase activity
A3778_RS00240	COG1131	(ABC) transporter
A3778_RS00265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A3778_RS00270	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3778_RS00275	COG1674	ftsk spoiiie
A3778_RS00285	COG0670	Belongs to the BI1 family
A3778_RS00290	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A3778_RS00290	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A3778_RS00295	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A3778_RS00300	COG0237	dephospho-CoA kinase activity
A3778_RS00310	COG3611	Membrane attachment protein
A3778_RS00315	COG1484	DNA-dependent DNA replication
A3778_RS00345	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A3778_RS00370	COG0400	carboxylic ester hydrolase activity
A3778_RS00380	COG0346	lactoylglutathione lyase activity
A3778_RS00385	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
A3778_RS00390	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A3778_RS00395	COG1534	Rna-binding protein
A3778_RS00400	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A3778_RS00410	COG0799	negative regulation of ribosome biogenesis
A3778_RS00415	COG2226	methyltransferase
A3778_RS00435	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A3778_RS00440	COG0745	RESPONSE REGULATOR receiver
A3778_RS00445	COG5002	protein histidine kinase activity
A3778_RS00450	COG0706	membrane insertase activity
A3778_RS00460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A3778_RS00470	COG1733	regulation of RNA biosynthetic process
A3778_RS00485	COG0072	phenylalanine-tRNA ligase activity
A3778_RS00490	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A3778_RS00495	COG0572	uridine kinase
A3778_RS00500	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A3778_RS00510	COG4585	Histidine kinase
A3778_RS00515	COG2197	response regulator
A3778_RS00520	COG4841	protein insertion into membrane
A3778_RS00530	COG0768	penicillin binding
A3778_RS00535	COG0705	Rhomboid family
A3778_RS00535	COG0457	Tetratricopeptide repeat
A3778_RS00545	COG1940	carbohydrate kinase activity
A3778_RS00550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A3778_RS00565	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
A3778_RS00570	COG1982	Orn Lys Arg decarboxylase major
A3778_RS00575	COG0789	Transcriptional regulator
A3778_RS00610	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A3778_RS00615	COG2868	ribosomal protein
A3778_RS00620	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A3778_RS00625	COG0006	proline dipeptidase activity
A3778_RS00630	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A3778_RS00635	COG1302	Protein conserved in bacteria
A3778_RS00655	COG1722	exodeoxyribonuclease VII activity
A3778_RS00660	COG0142	geranyltranstransferase activity
A3778_RS00665	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A3778_RS00670	COG1438	arginine binding
A3778_RS00675	COG0497	DNA recombination
A3778_RS00695	COG0194	GDP metabolic process
A3778_RS00705	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A3778_RS00710	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A3778_RS00720	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A3778_RS00720	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A3778_RS00730	COG2815	serine threonine protein kinase
A3778_RS00730	COG0515	serine threonine protein kinase
A3778_RS00735	COG1162	GTPase activity
A3778_RS00740	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A3778_RS00745	COG1564	THIamine pyrophosphokinase
A3778_RS00775	COG1461	Dihydroxyacetone kinase
A3778_RS00780	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A3778_RS00790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A3778_RS00800	COG4608	Belongs to the ABC transporter superfamily
A3778_RS00805	COG0601	transmembrane transport
A3778_RS00810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3778_RS00815	COG0747	negative chemotaxis
A3778_RS00820	COG0571	ribonuclease III activity
A3778_RS00825	COG1196	nuclear chromosome segregation
A3778_RS00830	COG0552	protein localization to endoplasmic reticulum
A3778_RS00850	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A3778_RS00860	COG1837	Belongs to the UPF0109 family
A3778_RS00890	COG4224	UPF0291 protein
A3778_RS00895	COG3763	UPF0154 protein
A3778_RS00900	COG1132	(ABC) transporter
A3778_RS00905	COG1132	(ABC) transporter
A3778_RS00915	COG0531	amino acid
A3778_RS00920	COG0204	Acyl-transferase
A3778_RS00925	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A3778_RS00955	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A3778_RS00960	COG4589	Belongs to the CDS family
A3778_RS00965	COG0750	zinc metalloprotease
A3778_RS00985	COG0195	Participates in both transcription termination and antitermination
A3778_RS00990	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A3778_RS01010	COG0861	Integral membrane protein TerC family
A3778_RS01020	COG0196	riboflavin kinase activity
A3778_RS01025	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A3778_RS01035	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A3778_RS01090	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A3778_RS01090	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A3778_RS01105	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A3778_RS01170	COG2094	Belongs to the DNA glycosylase MPG family
A3778_RS01185	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A3778_RS01195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A3778_RS01210	COG3103	Sh3 type 3 domain protein
A3778_RS01210	COG4991	sh3 domain protein
A3778_RS01210	COG0860	N-Acetylmuramoyl-L-alanine amidase
A3778_RS01220	COG1131	(ABC) transporter
A3778_RS01245	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A3778_RS01250	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A3778_RS01255	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A3778_RS01270	COG1610	YqeY-like protein
A3778_RS01275	COG1702	phosphate starvation-inducible protein PhoH
A3778_RS01290	COG0295	cytidine deaminase activity
A3778_RS01300	COG1381	Involved in DNA repair and RecF pathway recombination
A3778_RS01325	COG0358	DNA primase activity
A3778_RS01330	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A3778_RS01335	COG2384	SAM-dependent methyltransferase
A3778_RS01340	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A3778_RS01345	COG1942	4-Oxalocrotonate Tautomerase
A3778_RS01350	COG2151	metal-sulfur cluster biosynthetic enzyme
A3778_RS01365	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A3778_RS01365	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A3778_RS01395	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A3778_RS01395	COG1199	ATP-dependent helicase activity
A3778_RS01410	COG0436	Aminotransferase
A3778_RS01425	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A3778_RS01430	COG2131	deaminase
A3778_RS01435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A3778_RS01465	COG0116	Belongs to the methyltransferase superfamily
A3778_RS01485	COG0095	Lipoate-protein ligase
A3778_RS01490	COG3590	peptidase
A3778_RS01495	COG0583	DNA-binding transcription factor activity
A3778_RS01505	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A3778_RS01510	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A3778_RS01515	COG1393	Belongs to the ArsC family
A3778_RS01530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A3778_RS01540	COG0328	RNA-DNA hybrid ribonuclease activity
A3778_RS01555	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A3778_RS01560	COG0564	pseudouridine synthase activity
A3778_RS01570	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A3778_RS01575	COG2233	PERMEase
A3778_RS01585	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A3778_RS01590	COG0505	Belongs to the CarA family
A3778_RS01605	COG0284	orotidine-5'-phosphate decarboxylase activity
A3778_RS01610	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A3778_RS01615	COG0280	phosphate acetyltransferase
A3778_RS01620	COG3426	butyrate kinase activity
A3778_RS01625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A3778_RS01630	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A3778_RS01635	COG0022	dehydrogenase e1 component
A3778_RS01640	COG0508	dehydrogenase complex catalyzes the overall conversion of
A3778_RS01645	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A3778_RS01660	COG1293	RNA-binding protein homologous to eukaryotic snRNP
A3778_RS01665	COG1307	EDD domain protein, DegV family
A3778_RS01670	COG0494	nUDIX hydrolase
A3778_RS01680	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A3778_RS01695	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A3778_RS01730	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A3778_RS01735	COG0778	Nitroreductase
A3778_RS01760	COG0745	RESPONSE REGULATOR receiver
A3778_RS01765	COG5002	protein histidine kinase activity
A3778_RS01770	COG1136	(ABC) transporter
A3778_RS01775	COG0577	efflux transmembrane transporter activity
A3778_RS01785	COG4974	Belongs to the 'phage' integrase family
A3778_RS01790	COG1227	inorganic diphosphatase activity
A3778_RS01795	COG0583	DNA-binding transcription factor activity
A3778_RS01800	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A3778_RS01805	COG1882	Formate acetyltransferase
A3778_RS01810	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A3778_RS01815	COG0187	DNA topoisomerase II activity
A3778_RS01835	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A3778_RS01860	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A3778_RS01870	COG0758	DNA mediated transformation
A3778_RS01925	COG0793	Belongs to the peptidase S41A family
A3778_RS01925	COG3409	Peptidoglycan-binding domain 1 protein
A3778_RS01935	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A3778_RS01945	COG2755	lipolytic protein G-D-S-L family
A3778_RS01950	COG1307	EDD domain protein, DegV family
A3778_RS01955	COG1272	protein, Hemolysin III
A3778_RS01970	COG0488	(ABC) transporter
A3778_RS01985	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A3778_RS01990	COG0457	Tetratricopeptide repeat
A3778_RS02005	COG0539	negative regulation of cytoplasmic translation
A3778_RS02020	COG0514	ATP-dependent DNA helicase (RecQ)
A3778_RS02035	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
A3778_RS02040	COG1187	pseudouridine synthase activity
A3778_RS02045	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A3778_RS02050	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A3778_RS02055	COG0456	acetyltransferase
A3778_RS02065	COG2996	Protein conserved in bacteria
A3778_RS02085	COG0587	DNA-directed DNA polymerase activity
A3778_RS02100	COG0737	Belongs to the 5'-nucleotidase family
A3778_RS02115	COG0542	response to heat
A3778_RS02130	COG0300	oxidoreductase activity
A3778_RS02140	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A3778_RS02140	COG2755	lipolytic protein G-D-S-L family
A3778_RS02150	COG1349	DNA-binding transcription factor activity
A3778_RS02155	COG1105	Belongs to the carbohydrate kinase PfkB family
A3778_RS02160	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A3778_RS02160	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A3778_RS02160	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3778_RS02170	COG1126	abc transporter atp-binding protein
A3778_RS02175	COG0765	amino acid transport
A3778_RS02200	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A3778_RS02210	COG1132	(ABC) transporter
A3778_RS02225	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A3778_RS02275	COG1466	dna polymerase III delta subunit
A3778_RS02280	COG0658	competence protein
A3778_RS02280	COG2333	competence protein COMEC
A3778_RS02290	COG3480	Lon protease (S16) C-terminal proteolytic domain
A3778_RS02300	COG0742	ribosomal rna small subunit methyltransferase
A3778_RS02305	COG4471	UPF0298 protein
A3778_RS02310	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A3778_RS02315	COG0772	Belongs to the SEDS family
A3778_RS02320	COG1217	gtp-binding protein TYPA
A3778_RS02325	COG0483	inositol monophosphate 1-phosphatase activity
A3778_RS02395	COG1597	lipid kinase activity
A3778_RS02405	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A3778_RS02445	COG1104	cysteine desulfurase activity
A3778_RS02460	COG0494	nUDIX hydrolase
A3778_RS02470	COG3853	Toxic anion resistance protein (TelA)
A3778_RS02475	COG2814	Major facilitator Superfamily
A3778_RS02485	COG1278	Cold shock
A3778_RS02495	COG3599	regulation of cell shape
A3778_RS02515	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A3778_RS02545	COG0768	penicillin binding
A3778_RS02560	COG2001	Belongs to the MraZ family
A3778_RS02575	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A3778_RS02580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A3778_RS02590	COG0765	amino acid transport
A3778_RS02595	COG2894	cell division
A3778_RS02600	COG0850	regulation of cytokinetic process
A3778_RS02610	COG1792	Involved in formation and maintenance of cell shape
A3778_RS02615	COG1077	Cell shape determining protein MreB Mrl
A3778_RS02620	COG2003	Belongs to the UPF0758 family
A3778_RS02635	COG0525	valine-tRNA ligase activity
A3778_RS02640	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
A3778_RS02655	COG1104	cysteine desulfurase activity
A3778_RS02660	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
A3778_RS02665	COG1956	GAF domain-containing protein
A3778_RS02690	COG3620	sequence-specific DNA binding
A3778_RS02695	COG2183	response to ionizing radiation
A3778_RS02730	COG0789	Transcriptional regulator
A3778_RS02740	COG1131	(ABC) transporter
A3778_RS02750	COG4585	Histidine kinase
A3778_RS02755	COG2197	response regulator
A3778_RS02760	COG1307	EDD domain protein, DegV family
A3778_RS02775	COG0454	-acetyltransferase
A3778_RS02810	COG0583	DNA-binding transcription factor activity
A3778_RS02830	COG0745	RESPONSE REGULATOR receiver
A3778_RS02835	COG2205	protein histidine kinase activity
A3778_RS02840	COG4166	transmembrane transport
A3778_RS02850	COG1428	Deoxynucleoside kinase
A3778_RS02860	COG1028	Short-chain dehydrogenase reductase Sdr
A3778_RS02875	COG1760	l-serine dehydratase
A3778_RS02880	COG1760	l-serine dehydratase
A3778_RS02890	COG5506	Protein of unknown function (DUF1694)
A3778_RS02895	COG0189	ligase activity
A3778_RS02895	COG2918	glutathione biosynthetic process
A3778_RS02900	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A3778_RS02920	COG0589	response to stress
A3778_RS02950	COG0719	Fe-S assembly protein
A3778_RS02955	COG0822	iron-sulfur transferase activity
A3778_RS02960	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A3778_RS02965	COG0719	Fe-S assembly protein
A3778_RS02975	COG2011	ABC-type metal ion transport system permease component
A3778_RS02985	COG1464	Belongs to the NlpA lipoprotein family
A3778_RS02990	COG1464	Belongs to the NlpA lipoprotein family
A3778_RS02995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A3778_RS03000	COG0509	glycine decarboxylation via glycine cleavage system
A3778_RS03005	COG0772	Belongs to the SEDS family
A3778_RS03025	COG1077	Cell shape determining protein MreB Mrl
A3778_RS03070	COG0356	it plays a direct role in the translocation of protons across the membrane
A3778_RS03085	COG0009	L-threonylcarbamoyladenylate synthase
A3778_RS03090	COG2890	protein-(glutamine-N5) methyltransferase activity
A3778_RS03100	COG1435	thymidine kinase activity
A3778_RS03105	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A3778_RS03115	COG2514	catechol 2,3-dioxygenase activity
A3778_RS03170	COG2814	Major facilitator Superfamily
A3778_RS03190	COG0590	tRNA wobble adenosine to inosine editing
A3778_RS03440	COG3723	Recombinational DNA repair protein, rece pathway
A3778_RS03470	COG3561	AntA/AntB antirepressor
A3778_RS03545	COG0582	viral genome integration into host DNA
A3778_RS03555	COG4975	Glucose uptake
A3778_RS03570	COG1368	sulfuric ester hydrolase activity
A3778_RS03585	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A3778_RS03590	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A3778_RS03615	COG1705	Flagellar rod assembly protein muramidase FlgJ
A3778_RS03625	COG1278	Cold shock
A3778_RS03645	COG4129	membrane
A3778_RS03655	COG0463	Glycosyl transferase, family 2
A3778_RS03665	COG4485	Bacterial membrane protein, YfhO
A3778_RS03675	COG3711	transcriptional antiterminator
A3778_RS03680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3778_RS03680	COG2190	(PTS) system
A3778_RS03680	COG1263	PTS System
A3778_RS03740	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A3778_RS03760	COG0463	Glycosyl transferase, family 2
A3778_RS03770	COG0024	Methionine aminopeptidase
A3778_RS03775	COG0716	FMN binding
A3778_RS03780	COG1295	ribonuclease BN
A3778_RS03805	COG2309	aminopeptidase activity
A3778_RS03810	COG0514	ATP-dependent DNA helicase (RecQ)
A3778_RS03830	COG1447	Phosphotransferase system cellobiose-specific component IIA
A3778_RS03840	COG0673	inositol 2-dehydrogenase activity
A3778_RS03895	COG3590	peptidase
A3778_RS03900	COG2326	polyphosphate kinase activity
A3778_RS03905	COG0561	phosphatase activity
A3778_RS03910	COG2814	Major facilitator Superfamily
A3778_RS03920	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A3778_RS03985	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A3778_RS04015	COG3850	Histidine kinase
A3778_RS04015	COG5002	protein histidine kinase activity
A3778_RS04020	COG0745	RESPONSE REGULATOR receiver
A3778_RS04070	COG1113	amino acid transport
A3778_RS04080	COG0827	DNA restriction-modification system
A3778_RS04110	COG1459	type II secretion system
A3778_RS04115	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A3778_RS04135	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A3778_RS04165	COG1309	transcriptional regulator
A3778_RS04170	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A3778_RS04185	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A3778_RS04190	COG1177	transmembrane transport
A3778_RS04195	COG1176	ABC-type spermidine putrescine transport system, permease component I
A3778_RS04205	COG3800	Transcriptional regulator
A3778_RS04205	COG1396	sequence-specific DNA binding
A3778_RS04220	COG0708	Exodeoxyribonuclease III
A3778_RS04230	COG1668	transmembrane transport
A3778_RS04235	COG4152	abc transporter atp-binding protein
A3778_RS04245	COG0802	atpase or kinase
A3778_RS04250	COG0280	phosphate acetyltransferase
A3778_RS04260	COG0561	phosphatase activity
A3778_RS04280	COG1175	transmembrane transport
A3778_RS04285	COG0395	ABC-type sugar transport system, permease component
A3778_RS04325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A3778_RS04340	COG0366	Alpha amylase catalytic
A3778_RS04345	COG1609	Transcriptional regulator
A3778_RS04355	COG0557	exoribonuclease II activity
A3778_RS04365	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A3778_RS04405	COG2390	Transcriptional regulator
A3778_RS04500	COG0740	serine-type endopeptidase activity
A3778_RS04565	COG0629	single-stranded DNA binding
A3778_RS04615	COG1396	sequence-specific DNA binding
A3778_RS04640	COG0582	viral genome integration into host DNA
A3778_RS04655	COG1846	Transcriptional regulator
A3778_RS04665	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A3778_RS04685	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A3778_RS04710	COG1136	(ABC) transporter
A3778_RS04715	COG2205	protein histidine kinase activity
A3778_RS04720	COG0745	RESPONSE REGULATOR receiver
A3778_RS04725	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A3778_RS04735	COG0492	ferredoxin-NADP+ reductase activity
A3778_RS04745	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A3778_RS04755	COG1950	PFAM Membrane protein of
A3778_RS04770	COG0704	Plays a role in the regulation of phosphate uptake
A3778_RS04775	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A3778_RS04780	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A3778_RS04785	COG0581	inorganic phosphate transmembrane transporter activity
A3778_RS04790	COG0573	inorganic phosphate transmembrane transporter activity
A3778_RS04800	COG5002	protein histidine kinase activity
A3778_RS04805	COG0745	RESPONSE REGULATOR receiver
A3778_RS04815	COG2177	Part of the ABC transporter FtsEX involved in
A3778_RS04820	COG2884	Cell division ATP-binding protein ftsE
A3778_RS04850	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
A3778_RS04855	COG1739	Uncharacterized protein family UPF0029
A3778_RS04865	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A3778_RS04875	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A3778_RS04880	COG1426	Protein conserved in bacteria
A3778_RS04885	COG1028	Short-chain dehydrogenase reductase Sdr
A3778_RS04890	COG0612	Peptidase, M16
A3778_RS04895	COG0612	Peptidase, M16
A3778_RS04900	COG1674	ftsk spoiiie
A3778_RS04910	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A3778_RS04920	COG2226	methyltransferase
A3778_RS04935	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A3778_RS04945	COG2706	6-phosphogluconolactonase activity
A3778_RS04955	COG3142	Participates in the control of copper homeostasis
A3778_RS04965	COG0564	pseudouridine synthase activity
A3778_RS04975	COG2357	RelA SpoT domain protein
A3778_RS05000	COG3830	Belongs to the UPF0237 family
A3778_RS05010	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A3778_RS05015	COG0386	Belongs to the glutathione peroxidase family
A3778_RS05020	COG0438	transferase activity, transferring glycosyl groups
A3778_RS05040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A3778_RS05050	COG1187	pseudouridine synthase activity
A3778_RS05055	COG2244	polysaccharide biosynthetic process
A3778_RS05075	COG0671	phosphoesterase, PA-phosphatase related
A3778_RS05085	COG2814	Major facilitator Superfamily
A3778_RS05095	COG0477	Major facilitator Superfamily
A3778_RS05140	COG0735	belongs to the Fur family
A3778_RS05145	COG1368	sulfuric ester hydrolase activity
A3778_RS05160	COG0436	Aminotransferase
A3778_RS05175	COG0438	transferase activity, transferring glycosyl groups
A3778_RS05180	COG0438	transferase activity, transferring glycosyl groups
A3778_RS05185	COG0531	amino acid
A3778_RS05335	COG1098	S1 RNA binding domain
A3778_RS05350	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A3778_RS05355	COG0586	Pfam SNARE associated Golgi protein
A3778_RS05370	COG0647	UMP catabolic process
A3778_RS05375	COG4470	Protein conserved in bacteria
A3778_RS05380	COG0737	Belongs to the 5'-nucleotidase family
A3778_RS05420	COG1011	Hydrolase
A3778_RS05425	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A3778_RS05430	COG1609	Transcriptional regulator
A3778_RS05435	COG0006	proline dipeptidase activity
A3778_RS05440	COG1827	regulation of RNA biosynthetic process
A3778_RS05455	COG0668	transmembrane transport
A3778_RS05470	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A3778_RS05480	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A3778_RS05485	COG1719	4-vinyl reductase, 4VR
A3778_RS05490	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A3778_RS05500	COG1696	Membrane protein involved in D-alanine export
A3778_RS05515	COG3118	belongs to the thioredoxin family
A3778_RS05575	COG0513	Belongs to the DEAD box helicase family
A3778_RS05580	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A3778_RS05585	COG4109	DRTGG domain
A3778_RS05590	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A3778_RS05595	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A3778_RS05605	COG1012	belongs to the aldehyde dehydrogenase family
A3778_RS05605	COG1454	alcohol dehydrogenase
A3778_RS05610	COG1862	Preprotein translocase
A3778_RS05615	COG0343	queuine tRNA-ribosyltransferase activity
A3778_RS05620	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A3778_RS05645	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A3778_RS05685	COG2267	carboxylic ester hydrolase activity
A3778_RS05715	COG2267	carboxylic ester hydrolase activity
A3778_RS05720	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A3778_RS05725	COG0105	UTP biosynthetic process
A3778_RS05730	COG1028	Short-chain dehydrogenase reductase Sdr
A3778_RS05745	COG1132	(ABC) transporter
A3778_RS05760	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A3778_RS05785	COG3189	MarR family transcriptional regulator
A3778_RS05790	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A3778_RS05805	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A3778_RS05830	COG0628	permease
A3778_RS05845	COG0604	alcohol dehydrogenase
A3778_RS05885	COG1304	FMN binding
A3778_RS05890	COG0778	Nitroreductase
A3778_RS05905	COG2508	Transcriptional regulator
A3778_RS05915	COG5002	protein histidine kinase activity
A3778_RS05920	COG0745	RESPONSE REGULATOR receiver
A3778_RS05930	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A3778_RS05935	COG0463	Glycosyl transferase, family 2
A3778_RS05945	COG0604	alcohol dehydrogenase
A3778_RS05955	COG4120	Belongs to the binding-protein-dependent transport system permease family
A3778_RS05975	COG1472	Belongs to the glycosyl hydrolase 3 family
A3778_RS05985	COG2910	NAD(P)H-binding
A3778_RS06000	COG0351	phosphomethylpyrimidine kinase
A3778_RS06020	COG2249	NAD(P)H dehydrogenase (quinone) activity
A3778_RS06030	COG1194	a g-specific adenine glycosylase
A3778_RS06060	COG0419	ATPase involved in DNA repair
A3778_RS06075	COG1349	DNA-binding transcription factor activity
A3778_RS06090	COG3684	Belongs to the aldolase LacD family
A3778_RS06110	COG3775	system Galactitol-specific IIC component
A3778_RS06135	COG2017	converts alpha-aldose to the beta-anomer
A3778_RS06140	COG1609	Transcriptional regulator
A3778_RS06145	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
A3778_RS06150	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A3778_RS06160	COG1215	transferase activity, transferring glycosyl groups
A3778_RS06165	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A3778_RS06175	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A3778_RS06180	COG1573	uracil-dna glycosylase
A3778_RS06185	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A3778_RS06190	COG0488	(ABC) transporter
A3778_RS06210	COG1131	(ABC) transporter
A3778_RS06235	COG1285	pathogenesis
A3778_RS06245	COG0004	ammonium transporteR
A3778_RS06290	COG0025	NhaP-type Na H and K H
A3778_RS06300	COG1113	amino acid transport
A3778_RS06305	COG0656	L-ascorbic acid biosynthetic process
A3778_RS06315	COG0702	epimerase
A3778_RS06320	COG0488	(ABC) transporter
A3778_RS06335	COG1278	Cold shock
A3778_RS06340	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A3778_RS06350	COG0039	L-malate dehydrogenase activity
A3778_RS06355	COG0531	amino acid
A3778_RS06365	COG2190	(PTS) system
A3778_RS06365	COG1263	PTS System
A3778_RS06365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3778_RS06370	COG0366	Alpha amylase catalytic
A3778_RS06375	COG2188	Transcriptional regulator
A3778_RS06380	COG2223	nitrite transmembrane transporter activity
A3778_RS06385	COG1132	(ABC) transporter
A3778_RS06390	COG1132	(ABC) transporter
A3778_RS06400	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A3778_RS06405	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A3778_RS06420	COG1131	(ABC) transporter
A3778_RS06430	COG0697	spore germination
A3778_RS06480	COG1114	Component of the transport system for branched-chain amino acids
A3778_RS06490	COG0765	amino acid transport
A3778_RS06495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A3778_RS06500	COG0626	cystathionine gamma-synthase activity
A3778_RS06515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A3778_RS06525	COG1174	glycine betaine transport
A3778_RS06565	COG0390	transport system, permease component
A3778_RS06570	COG4619	ABC transporter
A3778_RS06590	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A3778_RS06600	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A3778_RS06635	COG0431	NADPH-dependent FMN reductase
A3778_RS06635	COG1053	succinate dehydrogenase
A3778_RS06635	COG3976	FMN-binding domain protein
A3778_RS06680	COG3764	Sortase (surface protein transpeptidase)
A3778_RS06710	COG3547	Transposase (IS116 IS110 IS902 family)
A3778_RS06860	COG2801	Transposase and inactivated derivatives
A3778_RS06895	COG2826	transposase and inactivated derivatives, IS30 family
A3778_RS07030	COG1396	sequence-specific DNA binding
A3778_RS07085	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A3778_RS07090	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
A3778_RS07095	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A3778_RS07100	COG2271	Major facilitator Superfamily
A3778_RS07110	COG1028	Short-chain dehydrogenase reductase Sdr
A3778_RS07130	COG0531	amino acid
A3778_RS07135	COG0308	aminopeptidase N
A3778_RS07170	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A3778_RS07190	COG1131	(ABC) transporter
A3778_RS07220	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A3778_RS07235	COG0656	L-ascorbic acid biosynthetic process
A3778_RS07240	COG0789	Transcriptional regulator
A3778_RS07255	COG0174	glutamine synthetase
A3778_RS07260	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A3778_RS07265	COG2226	methyltransferase
A3778_RS07280	COG0028	Belongs to the TPP enzyme family
A3778_RS07300	COG2814	Major facilitator Superfamily
A3778_RS07325	COG2376	Dihydroxyacetone kinase
A3778_RS07330	COG1461	Dihydroxyacetone kinase
A3778_RS07335	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
A3778_RS07365	COG1464	Belongs to the NlpA lipoprotein family
A3778_RS07390	COG1132	(ABC) transporter
A3778_RS07395	COG0366	Alpha amylase catalytic
A3778_RS07420	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3778_RS07425	COG1609	Transcriptional regulator
A3778_RS07435	COG0561	phosphatase activity
A3778_RS07440	COG0446	pyridine nucleotide-disulphide oxidoreductase
A3778_RS07465	COG4221	oxidoreductase activity
A3778_RS07485	COG0477	Major facilitator Superfamily
A3778_RS07515	COG1349	DNA-binding transcription factor activity
A3778_RS07520	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A3778_RS07525	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A3778_RS07530	COG1349	DNA-binding transcription factor activity
A3778_RS07535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A3778_RS07585	COG1122	ATPase activity
A3778_RS07600	COG0583	DNA-binding transcription factor activity
A3778_RS07610	COG0471	metal ion transport
A3778_RS07615	COG0191	fructose-bisphosphate aldolase activity
A3778_RS07620	COG3716	PTS system mannose fructose sorbose family IID component
A3778_RS07625	COG3715	PTS system
A3778_RS07630	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3778_RS07635	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3778_RS07645	COG2390	Transcriptional regulator
A3778_RS07655	COG1609	Transcriptional regulator
A3778_RS07660	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A3778_RS07665	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A3778_RS07670	COG2376	Dihydroxyacetone kinase
A3778_RS07675	COG1461	Dihydroxyacetone kinase
A3778_RS07680	COG0246	Mannitol dehydrogenase
A3778_RS07685	COG3716	PTS system mannose fructose sorbose family IID component
A3778_RS07690	COG3715	PTS system
A3778_RS07695	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3778_RS07695	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3778_RS07705	COG1028	Short-chain dehydrogenase reductase Sdr
A3778_RS07710	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3778_RS07710	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A3778_RS07710	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A3778_RS07715	COG0191	fructose-bisphosphate aldolase activity
A3778_RS07730	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A3778_RS07735	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A3778_RS07735	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A3778_RS07740	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A3778_RS07740	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A3778_RS07740	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3778_RS07760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3778_RS07760	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A3778_RS07760	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A3778_RS07765	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A3778_RS07770	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A3778_RS07770	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3778_RS07770	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A3778_RS07780	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A3778_RS07780	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3778_RS07785	COG3711	transcriptional antiterminator
A3778_RS07795	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A3778_RS07810	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3778_RS07815	COG3715	PTS system
A3778_RS07820	COG3716	PTS system mannose fructose sorbose family IID component
A3778_RS07830	COG0641	radical SAM
A3778_RS07840	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A3778_RS07850	COG3716	PTS system mannose fructose sorbose family IID component
A3778_RS07860	COG1609	Transcriptional regulator
A3778_RS07920	COG2267	carboxylic ester hydrolase activity
A3778_RS07935	COG1378	Sugar-specific transcriptional regulator TrmB
A3778_RS07965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3778_RS07970	COG1053	succinate dehydrogenase
A3778_RS07990	COG1131	(ABC) transporter
A3778_RS08050	COG2814	Major facilitator Superfamily
A3778_RS08070	COG1879	ABC-type sugar transport system periplasmic component
A3778_RS08075	COG1172	Belongs to the binding-protein-dependent transport system permease family
A3778_RS08090	COG1609	Transcriptional regulator
A3778_RS08100	COG0531	amino acid
A3778_RS08105	COG0351	phosphomethylpyrimidine kinase
A3778_RS08125	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A3778_RS08135	COG1129	ABC transporter
A3778_RS08160	COG4166	transmembrane transport
A3778_RS08165	COG2195	Cleaves the N-terminal amino acid of tripeptides
A3778_RS08175	COG1363	Peptidase, m42
A3778_RS08185	COG1447	Phosphotransferase system cellobiose-specific component IIA
A3778_RS08190	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A3778_RS08195	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A3778_RS08205	COG0006	proline dipeptidase activity
A3778_RS08210	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A3778_RS08220	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3778_RS08220	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3778_RS08225	COG3716	PTS system mannose fructose sorbose family IID component
A3778_RS08230	COG3715	PTS system
A3778_RS08235	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3778_RS08250	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A3778_RS08255	COG2222	sugar isomerase
A3778_RS08260	COG2188	Transcriptional regulator
A3778_RS08265	COG1482	cell wall glycoprotein biosynthetic process
A3778_RS08270	COG3064	Membrane
A3778_RS08270	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A3778_RS08270	COG3583	domain protein
A3778_RS08280	COG2182	Extracellular solute-binding protein
A3778_RS08300	COG0446	pyridine nucleotide-disulphide oxidoreductase
A3778_RS08305	COG2723	6-phospho-beta-galactosidase activity
A3778_RS08330	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A3778_RS08335	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A3778_RS08345	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A3778_RS08375	COG0683	leucine binding
A3778_RS08395	COG3118	belongs to the thioredoxin family
A3778_RS08420	COG0488	(ABC) transporter
A3778_RS08445	COG1216	Glycosyl transferase, family 2
A3778_RS08460	COG1114	Component of the transport system for branched-chain amino acids
A3778_RS08465	COG1316	TRANSCRIPTIONal
A3778_RS08470	COG1164	Oligoendopeptidase f
A3778_RS08475	COG2084	Dehydrogenase
A3778_RS08490	COG1121	(ABC) transporter
A3778_RS08500	COG2610	gluconate transmembrane transporter activity
A3778_RS08510	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A3778_RS08515	COG1737	Transcriptional regulator
A3778_RS08520	COG1942	4-Oxalocrotonate Tautomerase
A3778_RS08525	COG0191	fructose-bisphosphate aldolase activity
A3778_RS08535	COG0673	inositol 2-dehydrogenase activity
A3778_RS08540	COG0673	inositol 2-dehydrogenase activity
A3778_RS08545	COG3962	Belongs to the TPP enzyme family
A3778_RS08565	COG3718	enzyme involved in inositol metabolism
A3778_RS08570	COG1012	belongs to the aldehyde dehydrogenase family
A3778_RS08575	COG2814	Major facilitator Superfamily
A3778_RS08580	COG1349	DNA-binding transcription factor activity
A3778_RS08585	COG0656	L-ascorbic acid biosynthetic process
A3778_RS08590	COG1794	racemase activity, acting on amino acids and derivatives
A3778_RS08600	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A3778_RS08605	COG1686	Belongs to the peptidase S11 family
A3778_RS08625	COG0517	IMP dehydrogenase activity
A3778_RS08625	COG0516	GMP reductase activity
A3778_RS08635	COG0012	GTP binding
A3778_RS08640	COG4481	Protein conserved in bacteria
A3778_RS08645	COG1475	DNA binding
A3778_RS08650	COG1192	Involved in chromosome partitioning
A3778_RS08670	COG3442	glutamine amidotransferase
A3778_RS08700	COG1302	Protein conserved in bacteria
A3778_RS08715	COG2261	transglycosylase associated protein
A3778_RS08730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A3778_RS08745	COG0716	FMN binding
A3778_RS08785	COG0446	pyridine nucleotide-disulphide oxidoreductase
A3778_RS08800	COG1396	sequence-specific DNA binding
A3778_RS08805	COG1132	(ABC) transporter
A3778_RS08830	COG1131	(ABC) transporter
A3778_RS08850	COG4166	transmembrane transport
A3778_RS08855	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
A3778_RS08865	COG0477	Major facilitator Superfamily
A3778_RS08875	COG1511	domain protein
A3778_RS08875	COG1511	domain protein
A3778_RS08900	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A3778_RS08960	COG0346	lactoylglutathione lyase activity
A3778_RS08980	COG2391	methyltransferase activity
A3778_RS08985	COG0446	pyridine nucleotide-disulphide oxidoreductase
A3778_RS08990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A3778_RS08995	COG4521	taurine ABC transporter
A3778_RS09000	COG1116	anion transmembrane transporter activity
A3778_RS09015	COG2252	PERMEase
A3778_RS09050	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A3778_RS09120	COG1328	CTP reductase activity
A3778_RS09140	COG3620	sequence-specific DNA binding
A3778_RS09145	COG0583	DNA-binding transcription factor activity
A3778_RS09150	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A3778_RS09155	COG0640	Transcriptional regulator
A3778_RS09160	COG2217	Heavy metal translocating P-type atpase
A3778_RS09180	COG0577	efflux transmembrane transporter activity
A3778_RS09180	COG1136	(ABC) transporter
A3778_RS09185	COG1309	transcriptional regulator
A3778_RS09190	COG1737	Transcriptional regulator
A3778_RS09195	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A3778_RS09210	COG0305	Participates in initiation and elongation during chromosome replication
A3778_RS09260	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A3778_RS09265	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A3778_RS09270	COG0527	aspartate kinase activity
A3778_RS09275	COG0019	diaminopimelate decarboxylase activity
A3778_RS09295	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A3778_RS09320	COG1131	(ABC) transporter
A3778_RS09355	COG2814	Major facilitator Superfamily
A3778_RS09375	COG0134	indole-3-glycerol-phosphate synthase activity
A3778_RS09380	COG0135	phosphoribosylanthranilate isomerase activity
A3778_RS09385	COG0133	tryptophan synthase activity
A3778_RS09390	COG0159	tryptophan synthase activity
A3778_RS09400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A3778_RS09410	COG2217	Heavy metal translocating P-type atpase
A3778_RS09450	COG1732	Glycine betaine
A3778_RS09465	COG1309	transcriptional regulator
A3778_RS09470	COG2409	Drug exporters of the RND superfamily
A3778_RS09470	COG1033	growth of symbiont in host cell
A3778_RS09480	COG2814	Major facilitator Superfamily
A3778_RS09485	COG1132	(ABC) transporter
A3778_RS09510	COG0800	Aldolase
A3778_RS09635	COG3409	Peptidoglycan-binding domain 1 protein
A3778_RS09655	COG0561	phosphatase activity
A3778_RS09675	COG3942	CHAP domain
A3778_RS09715	COG1294	oxidase, subunit
A3778_RS09720	COG1271	oxidase subunit
A3778_RS09730	COG0629	single-stranded DNA binding
A3778_RS09745	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A3778_RS09755	COG0187	DNA topoisomerase II activity
A3778_RS09770	COG2501	S4 domain
A3778_RS09780	COG0592	DNA-directed DNA polymerase activity
A3778_RS09810	COG0706	membrane insertase activity
A3778_RS09850	COG1473	amidohydrolase
A3778_RS09855	COG0371	Dehydrogenase
A3778_RS09860	COG3711	transcriptional antiterminator
A3778_RS09865	COG1263	PTS System
A3778_RS09865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3778_RS09865	COG2190	(PTS) system
A3778_RS09870	COG2723	6-phospho-beta-galactosidase activity
A3778_RS09880	COG0577	efflux transmembrane transporter activity
A3778_RS09885	COG1136	(ABC) transporter
A3778_RS09885	COG0577	efflux transmembrane transporter activity
A3778_RS09905	COG0561	phosphatase activity
A3778_RS09920	COG2213	PTS system mannitol-specific
A3778_RS09930	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3778_RS09950	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A3778_RS09965	COG3711	transcriptional antiterminator
A3778_RS09970	COG2190	(PTS) system
A3778_RS09970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3778_RS09970	COG1263	PTS System
A3778_RS09975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3778_RS09975	COG1263	PTS System
A3778_RS10020	COG4565	transcriptional regulatory protein
A3778_RS10025	COG3290	protein histidine kinase activity
A3778_RS10030	COG3493	citrate carrier protein
A3778_RS10055	COG0561	phosphatase activity
A3778_RS10060	COG0110	maltose O-acetyltransferase activity
A3778_RS10065	COG0438	transferase activity, transferring glycosyl groups
A3778_RS10070	COG1305	Transglutaminase-like
A3778_RS10080	COG0714	Associated with various cellular activities
A3778_RS10095	COG0765	amino acid transport
A3778_RS10100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A3778_RS10110	COG3001	Fructosamine kinase
A3778_RS10115	COG4133	protoheme IX ABC transporter activity
A3778_RS10155	COG1126	abc transporter atp-binding protein
A3778_RS10160	COG0765	amino acid transport
A3778_RS10190	COG3715	PTS system
A3778_RS10195	COG3716	PTS system mannose fructose sorbose family IID component
A3778_RS10205	COG0667	Aldo Keto reductase
A3778_RS10210	COG2807	transmembrane transport
A3778_RS10215	COG2814	Major facilitator Superfamily
A3778_RS10225	COG1335	isochorismatase
A3778_RS10250	COG1447	Phosphotransferase system cellobiose-specific component IIA
A3778_RS10255	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A3778_RS10260	COG2188	Transcriptional regulator
A3778_RS10265	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A3778_RS10290	COG0765	amino acid transport
A3778_RS10295	COG0596	Alpha beta hydrolase
A3778_RS10305	COG0745	RESPONSE REGULATOR receiver
A3778_RS10310	COG5002	protein histidine kinase activity
A3778_RS10325	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A3778_RS10335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A3778_RS10350	COG2217	Heavy metal translocating P-type atpase
A3778_RS10360	COG4166	transmembrane transport
A3778_RS10375	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A3778_RS10405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A3778_RS10410	COG0789	Transcriptional regulator
A3778_RS10420	COG2365	Tyrosine phosphatase family
A3778_RS10425	COG0604	alcohol dehydrogenase
A3778_RS10450	COG2076	Multidrug Resistance protein
A3778_RS10460	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A3778_RS10480	COG3716	PTS system mannose fructose sorbose family IID component
A3778_RS10485	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3778_RS10490	COG1737	Transcriptional regulator
A3778_RS10495	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A3778_RS10505	COG4948	Mandelate Racemase Muconate Lactonizing
A3778_RS10520	COG1335	isochorismatase
A3778_RS10525	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A3778_RS10530	COG3842	ATPase activity
A3778_RS10540	COG0395	ABC-type sugar transport system, permease component
A3778_RS10550	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A3778_RS10555	COG0584	glycerophosphoryl diester phosphodiesterase
A3778_RS10585	COG0456	acetyltransferase
A3778_RS10590	COG0477	Major facilitator Superfamily
A3778_RS10605	COG2188	Transcriptional regulator
A3778_RS10610	COG0191	fructose-bisphosphate aldolase activity
A3778_RS10625	COG3775	system Galactitol-specific IIC component
A3778_RS10630	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A3778_RS10640	COG3711	transcriptional antiterminator
A3778_RS10640	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3778_RS10650	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3778_RS10650	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3778_RS10660	COG3716	PTS system mannose fructose sorbose family IID component
A3778_RS10665	COG1063	alcohol dehydrogenase
A3778_RS10670	COG1070	Carbohydrate kinase
A3778_RS10700	COG2188	Transcriptional regulator
A3778_RS10705	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A3778_RS10710	COG1446	asparaginase
A3778_RS10720	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
A3778_RS10725	COG1349	DNA-binding transcription factor activity
A3778_RS10730	COG1063	alcohol dehydrogenase
A3778_RS10740	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3778_RS10745	COG3715	PTS system
A3778_RS10750	COG3716	PTS system mannose fructose sorbose family IID component
A3778_RS10765	COG1063	alcohol dehydrogenase
A3778_RS10780	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3778_RS10795	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A3778_RS10800	COG1349	DNA-binding transcription factor activity
A3778_RS10805	COG3623	hexulose-6-phosphate isomerase
A3778_RS10810	COG0561	phosphatase activity
A3778_RS10830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3778_RS10830	COG1263	PTS System
A3778_RS10830	COG2190	(PTS) system
A3778_RS10835	COG1609	Transcriptional regulator
A3778_RS10840	COG2723	6-phospho-beta-galactosidase activity
A3778_RS10850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3778_RS10850	COG1263	PTS System
A3778_RS10850	COG2190	(PTS) system
A3778_RS10860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3778_RS10860	COG3711	transcriptional antiterminator
A3778_RS10870	COG3730	PTS system glucitol sorbitol-specific
A3778_RS10875	COG3732	PTS system glucitol sorbitol-specific
A3778_RS10925	COG3964	amidohydrolase
A3778_RS10945	COG0800	Aldolase
A3778_RS10950	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A3778_RS10975	COG2204	response regulator
A3778_RS10990	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A3778_RS11015	COG3775	system Galactitol-specific IIC component
A3778_RS11020	COG3414	Phosphotransferase system galactitol-specific IIB component
A3778_RS11060	COG2190	(PTS) system
A3778_RS11060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3778_RS11060	COG1263	PTS System
A3778_RS11070	COG3711	transcriptional antiterminator
A3778_RS11110	COG1263	PTS System
A3778_RS11110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3778_RS11120	COG0745	RESPONSE REGULATOR receiver
A3778_RS11125	COG0586	Pfam SNARE associated Golgi protein
A3778_RS11135	COG0463	Glycosyl transferase, family 2
A3778_RS11160	COG0366	Alpha amylase catalytic
A3778_RS11170	COG1349	DNA-binding transcription factor activity
A3778_RS11185	COG3775	system Galactitol-specific IIC component
A3778_RS11205	COG2188	Transcriptional regulator
A3778_RS11210	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A3778_RS11225	COG1940	carbohydrate kinase activity
A3778_RS11230	COG2723	6-phospho-beta-galactosidase activity
A3778_RS11240	COG1447	Phosphotransferase system cellobiose-specific component IIA
A3778_RS11245	COG3716	PTS system mannose fructose sorbose family IID component
A3778_RS11250	COG3715	PTS system
A3778_RS11255	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3778_RS11255	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3778_RS11285	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A3778_RS11295	COG1105	Belongs to the carbohydrate kinase PfkB family
A3778_RS11300	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3778_RS11300	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A3778_RS11300	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A3778_RS11320	COG1811	Na channel or pump
A3778_RS11325	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A3778_RS11330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A3778_RS11345	COG0561	phosphatase activity
A3778_RS11350	COG0588	phosphoglycerate mutase activity
A3778_RS11390	COG0667	Aldo Keto reductase
A3778_RS11395	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A3778_RS11405	COG1418	mRNA catabolic process
A3778_RS11435	COG3973	AAA domain
A3778_RS11450	COG1174	glycine betaine transport
A3778_RS11460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A3778_RS11465	COG0577	efflux transmembrane transporter activity
A3778_RS11465	COG1136	(ABC) transporter
A3778_RS11475	COG1704	LemA family
A3778_RS11480	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
A3778_RS11485	COG0534	Mate efflux family protein
A3778_RS11500	COG2226	methyltransferase
A3778_RS11505	COG4989	oxidoreductase activity
A3778_RS11520	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A3778_RS11525	COG0248	Ppx GppA phosphatase
A3778_RS11535	COG4086	secreted protein
A3778_RS11545	COG1881	PFAM PEBP family protein
A3778_RS11560	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A3778_RS11580	COG1801	Protein of unknown function DUF72
A3778_RS11590	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3778_RS11590	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3778_RS11605	COG3290	protein histidine kinase activity
A3778_RS11620	COG3684	Belongs to the aldolase LacD family
A3778_RS11630	COG0084	hydrolase, TatD family'
A3778_RS11635	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A3778_RS11640	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A3778_RS11645	COG4466	Protein conserved in bacteria
A3778_RS11650	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A3778_RS11660	COG0390	transport system, permease component
A3778_RS11665	COG4619	ABC transporter
A3778_RS11670	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A3778_RS11680	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A3778_RS11685	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A3778_RS11715	COG1078	dGTPase activity
A3778_RS11720	COG0095	Lipoate-protein ligase
A3778_RS11740	COG0504	CTP synthase activity
A3778_RS11750	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A3778_RS11790	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A3778_RS11815	COG2337	Toxic component of a toxin-antitoxin (TA) module
A3778_RS11820	COG4708	membrane
A3778_RS11830	COG0067	glutamate synthase
A3778_RS11830	COG0070	glutamate synthase
A3778_RS11830	COG0069	glutamate synthase activity
A3778_RS11840	COG0493	'glutamate synthase
A3778_RS11845	COG1376	ErfK ybiS ycfS ynhG family protein
A3778_RS11870	COG0039	L-malate dehydrogenase activity
A3778_RS11885	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A3778_RS11890	COG2244	polysaccharide biosynthetic process
A3778_RS11895	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A3778_RS11905	COG1098	S1 RNA binding domain
A3778_RS11910	COG0037	tRNA processing
A3778_RS11915	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A3778_RS11955	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A3778_RS11960	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A3778_RS12030	COG4463	regulation of RNA biosynthetic process
A3778_RS12035	COG0542	response to heat
A3778_RS12085	COG0450	alkyl hydroperoxide reductase
A3778_RS12195	COG0200	Binds to the 23S rRNA
A3778_RS12275	COG0789	Transcriptional regulator
A3778_RS12285	COG1136	(ABC) transporter
A3778_RS12290	COG0577	efflux transmembrane transporter activity
A3778_RS12335	COG2826	transposase and inactivated derivatives, IS30 family
A3778_RS12355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A3778_RS12360	COG1116	anion transmembrane transporter activity
A3778_RS12380	COG3639	organic phosphonate transmembrane transporter activity
A3778_RS12400	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A3778_RS12405	COG0148	phosphopyruvate hydratase activity
A3778_RS12420	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A3778_RS12515	COG1012	belongs to the aldehyde dehydrogenase family
A3778_RS12520	COG1121	(ABC) transporter
A3778_RS12525	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A3778_RS12555	COG2814	Major facilitator Superfamily
A3778_RS12565	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A3778_RS12570	COG1914	H( )-stimulated, divalent metal cation uptake system
A3778_RS12585	COG0114	fumarate hydratase activity
A3778_RS12590	COG1902	pentaerythritol trinitrate reductase activity
A3778_RS12595	COG4221	oxidoreductase activity
A3778_RS12600	COG4989	oxidoreductase activity
A3778_RS12625	COG0110	maltose O-acetyltransferase activity
A3778_RS12705	COG2274	protein secretion by the type I secretion system
A3778_RS12710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A3778_RS12755	COG1695	Transcriptional regulator
A3778_RS12800	COG3764	Sortase (surface protein transpeptidase)
A3778_RS12825	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A3778_RS12865	COG1304	FMN binding
A3778_RS12880	COG0588	phosphoglycerate mutase activity
A3778_RS12885	COG0517	IMP dehydrogenase activity
A3778_RS12890	COG0574	Belongs to the PEP-utilizing enzyme family
A3778_RS12890	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A3778_RS12900	COG1131	(ABC) transporter
A3778_RS12925	COG3152	Membrane
A3778_RS12930	COG2388	GCN5-related N-acetyl-transferase
A3778_RS12935	COG0756	dUTP diphosphatase activity
A3778_RS12940	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A3778_RS12945	COG4956	integral membrane protein (PIN domain superfamily)
A3778_RS12985	COG4932	domain protein
A3778_RS12985	COG4886	Leucine-rich repeat (LRR) protein
A3778_RS13000	COG4377	Putative membrane peptidase family (DUF2324)
A3778_RS13005	COG1737	Transcriptional regulator
A3778_RS13010	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A3778_RS13040	COG0277	FAD linked oxidase domain protein
A3778_RS13055	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
A3778_RS13060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A3778_RS13065	COG3688	RNA-binding protein containing a PIN domain
A3778_RS13100	COG1131	(ABC) transporter
A3778_RS13140	COG4939	FMN-binding domain protein
A3778_RS13170	COG0250	Participates in transcription elongation, termination and antitermination
A3778_RS13200	COG2096	Adenosyltransferase
A3778_RS13205	COG5646	InterPro IPR014922
A3778_RS13215	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A3778_RS13230	COG1012	belongs to the aldehyde dehydrogenase family
A3778_RS13235	COG0477	Major facilitator Superfamily
A3778_RS13280	COG1609	Transcriptional regulator
A3778_RS13290	COG0392	lysyltransferase activity
A3778_RS13290	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A3778_RS13295	COG2813	Specifically methylates the guanine in position
A3778_RS13305	COG0590	tRNA wobble adenosine to inosine editing
A3778_RS13320	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A3778_RS13355	COG3870	Protein conserved in bacteria
A3778_RS13360	COG0470	DNA polymerase III
A3778_RS13410	COG1214	PFAM Peptidase M22, glycoprotease
A3778_RS13415	COG1214	PFAM Peptidase M22, glycoprotease
A3778_RS13415	COG0456	acetyltransferase
A3778_RS13425	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A3778_RS13435	COG0488	(ABC) transporter
A3778_RS13440	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
A3778_RS13445	COG1725	Transcriptional regulator
A3778_RS13450	COG1131	(ABC) transporter
A3778_RS13460	COG1316	TRANSCRIPTIONal
A3778_RS13465	COG1266	CAAX protease self-immunity
A3778_RS13490	COG0531	amino acid
A3778_RS13525	COG2814	Major facilitator Superfamily
A3778_RS13530	COG1253	flavin adenine dinucleotide binding
A3778_RS13540	COG0505	Belongs to the CarA family
A3778_RS13550	COG2264	protein methyltransferase activity
A3778_RS13575	COG1063	alcohol dehydrogenase
A3778_RS13585	COG0789	Transcriptional regulator
A3778_RS13590	COG1268	BioY protein
A3778_RS13600	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A3778_RS13605	COG2365	Tyrosine phosphatase family
A3778_RS13620	COG2818	Glycosylase
A3778_RS13625	COG0697	spore germination
A3778_RS13655	COG1271	oxidase subunit
A3778_RS13660	COG1294	oxidase, subunit
A3778_RS13665	COG4988	ABC transporter
A3778_RS13670	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A3778_RS13695	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
A3778_RS13700	COG1518	maintenance of DNA repeat elements
A3778_RS13725	COG1132	(ABC) transporter
A3778_RS13730	COG1132	(ABC) transporter
A3778_RS13740	COG2190	(PTS) system
A3778_RS13740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3778_RS13740	COG1263	PTS System
A3778_RS13745	COG2723	6-phospho-beta-galactosidase activity
A3778_RS13760	COG0477	Major facilitator Superfamily
A3778_RS13780	COG1297	OPT oligopeptide transporter protein
A3778_RS13820	COG4152	abc transporter atp-binding protein
A3778_RS13830	COG0142	geranyltranstransferase activity
A3778_RS13850	COG0367	asparagine synthase
A3778_RS13875	COG0436	Aminotransferase
A3778_RS13880	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A3778_RS13895	COG2268	Band 7 protein
A3778_RS13900	COG0527	aspartate kinase activity
A3778_RS13905	COG0460	homoserine dehydrogenase
A3778_RS13950	COG0028	Belongs to the TPP enzyme family
A3778_RS13955	COG1597	lipid kinase activity
A3778_RS13975	COG0628	permease
A3778_RS14000	COG0588	phosphoglycerate mutase activity
A3778_RS14010	COG0494	nUDIX hydrolase
A3778_RS14015	COG1132	(ABC) transporter
A3778_RS14020	COG1846	Transcriptional regulator
A3778_RS14060	COG1979	alcohol dehydrogenase
A3778_RS14065	COG2267	carboxylic ester hydrolase activity
A3778_RS14080	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A3778_RS14090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A3778_RS14095	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A3778_RS14110	COG1028	Short-chain dehydrogenase reductase Sdr
A3778_RS14115	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A3778_RS14120	COG0511	ligase activity, forming carbon-carbon bonds
A3778_RS14130	COG0439	Biotin carboxylase
A3778_RS14150	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A3778_RS14155	COG0702	epimerase
A3778_RS14170	COG1609	Transcriptional regulator
A3778_RS14175	COG0366	Alpha amylase catalytic
A3778_RS14180	COG1263	PTS System
A3778_RS14180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3778_RS14180	COG2190	(PTS) system
A3778_RS14200	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A3778_RS14245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A3778_RS14305	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A3778_RS14325	COG1447	Phosphotransferase system cellobiose-specific component IIA
A3778_RS14345	COG1139	Iron-sulfur cluster binding protein
A3778_RS14350	COG1556	Lactate utilization protein
A3778_RS14365	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A3778_RS14375	COG2814	Major facilitator Superfamily
A3778_RS14380	COG4166	transmembrane transport
A3778_RS14385	COG0601	transmembrane transport
A3778_RS14390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3778_RS14395	COG0444	Belongs to the ABC transporter superfamily
A3778_RS14400	COG4608	Belongs to the ABC transporter superfamily
A3778_RS14425	COG1028	Short-chain dehydrogenase reductase Sdr
A3778_RS14430	COG4708	membrane
A3778_RS14445	COG1088	dTDP-glucose 4,6-dehydratase activity
A3778_RS14455	COG0489	protein tyrosine kinase activity
A3778_RS14460	COG0562	UDP-galactopyranose mutase
A3778_RS14470	COG1442	glycosyl transferase family 8
A3778_RS14470	COG1216	Glycosyl transferase, family 2
A3778_RS14475	COG1442	glycosyl transferase family 8
A3778_RS14475	COG1216	Glycosyl transferase, family 2
A3778_RS14510	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A3778_RS14520	COG1316	TRANSCRIPTIONal
A3778_RS14525	COG4464	protein tyrosine phosphatase activity
A3778_RS14535	COG1393	Belongs to the ArsC family
A3778_RS14555	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A3778_RS14565	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A3778_RS14580	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A3778_RS14590	COG0058	SHG alpha-glucan phosphorylase activity
A3778_RS14615	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A3778_RS14625	COG0456	acetyltransferase
A3778_RS14625	COG0454	-acetyltransferase
A3778_RS14630	COG0194	GDP metabolic process
A3778_RS14640	COG0735	belongs to the Fur family
A3778_RS14660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A3778_RS14665	COG0765	amino acid transport
A3778_RS14670	COG0765	amino acid transport
A3778_RS14690	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A3778_RS14705	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A3778_RS14710	COG0463	Glycosyl transferase, family 2
A3778_RS14740	COG0463	Glycosyl transferase, family 2
A3778_RS14760	COG0489	protein tyrosine kinase activity
A3778_RS14780	COG0726	polysaccharide deacetylase
A3778_RS14790	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A3778_RS14805	COG0531	amino acid
A3778_RS14810	COG1136	(ABC) transporter
A3778_RS14840	COG2267	carboxylic ester hydrolase activity
A3778_RS14845	COG0475	glutathione-regulated potassium exporter activity
A3778_RS14845	COG0569	domain protein
A3778_RS14860	COG3973	AAA domain
A3778_RS14865	COG1607	acyl-coa hydrolase
A3778_RS14870	COG4690	dipeptidase activity
A3778_RS14945	COG1349	DNA-binding transcription factor activity
A3778_RS14955	COG5549	protein import
A3778_RS14955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A3778_RS14990	COG1132	(ABC) transporter
A3778_RS15005	COG0640	Transcriptional regulator
A3778_RS15015	COG4166	transmembrane transport
A3778_RS15020	COG0601	transmembrane transport
A3778_RS15035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3778_RS15045	COG0444	Belongs to the ABC transporter superfamily
A3778_RS15050	COG4608	Belongs to the ABC transporter superfamily
A3778_RS15065	COG1131	(ABC) transporter
A3778_RS15070	COG1725	Transcriptional regulator
A3778_RS15090	COG2814	Major facilitator Superfamily
A3778_RS15105	COG1131	(ABC) transporter
A3778_RS15145	COG2851	Citrate transporter
A3778_RS15155	COG0511	ligase activity, forming carbon-carbon bonds
A3778_RS15190	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
A3778_RS15190	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
A3778_RS15235	COG0564	pseudouridine synthase activity
A3778_RS15270	COG0028	Belongs to the TPP enzyme family
A3778_RS15290	COG0833	amino acid
A3778_RS15425	COG1136	(ABC) transporter
A3778_RS15425	COG0577	efflux transmembrane transporter activity
A3778_RS15430	COG3104	oligopeptide transport
A3778_RS15450	COG4946	Tricorn protease homolog
A3778_RS15450	COG1506	peptidase
A3778_RS15450	COG0823	Involved in the tonB-independent uptake of proteins
A3778_RS15455	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A3778_RS15460	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A3778_RS15465	COG2188	Transcriptional regulator
A3778_RS15475	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A3778_RS15510	COG4120	Belongs to the binding-protein-dependent transport system permease family
A3778_RS15515	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
A3778_RS15520	COG3091	SprT-like family
A3778_RS15545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A3778_RS15570	COG0183	Belongs to the thiolase family
A3778_RS15580	COG3425	synthase
A3778_RS15585	COG0028	Belongs to the TPP enzyme family
A3778_RS15595	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A3778_RS15600	COG1447	Phosphotransferase system cellobiose-specific component IIA
A3778_RS15610	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A3778_RS15615	COG2723	6-phospho-beta-galactosidase activity
A3778_RS15620	COG2188	Transcriptional regulator
A3778_RS15630	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A3778_RS15655	COG3557	Belongs to the UPF0374 family
A3778_RS15670	COG0628	permease
A3778_RS15675	COG1253	flavin adenine dinucleotide binding
A3778_RS15690	COG0542	response to heat
A3778_RS15700	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3778_RS15710	COG2814	Major facilitator Superfamily
A3778_RS15720	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A3778_RS15735	COG2801	Transposase and inactivated derivatives
A3778_RS15745	COG0438	transferase activity, transferring glycosyl groups
A3778_RS15780	COG1192	Involved in chromosome partitioning
A3778_RS15825	COG2723	6-phospho-beta-galactosidase activity
A3778_RS15830	COG3711	transcriptional antiterminator
A3778_RS15835	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A3778_RS15840	COG2188	Transcriptional regulator
A3778_RS15850	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3778_RS15865	COG2188	Transcriptional regulator
A3778_RS15870	COG0366	Alpha amylase catalytic
A3778_RS15875	COG1263	PTS System
A3778_RS15875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3778_RS15875	COG2190	(PTS) system
A3778_RS15910	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A3778_RS15915	COG0517	IMP dehydrogenase activity
A3778_RS15915	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A3778_RS15925	COG3414	Phosphotransferase system galactitol-specific IIB component
A3778_RS15930	COG3775	system Galactitol-specific IIC component
A3778_RS15935	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3778_RS15935	COG3711	transcriptional antiterminator
A3778_RS15940	COG3711	transcriptional antiterminator
A3778_RS15950	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A3778_RS15970	COG1653	transport
A3778_RS15975	COG3842	ATPase activity
A3778_RS16080	COG1063	alcohol dehydrogenase
A3778_RS16090	COG0667	Aldo Keto reductase
A3778_RS16100	COG3716	PTS system mannose fructose sorbose family IID component
A3778_RS16105	COG3715	PTS system
A3778_RS16125	COG1192	Involved in chromosome partitioning
A3778_RS16170	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A3778_RS16175	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A3778_RS16185	COG1609	Transcriptional regulator
A3778_RS16190	COG3833	ABC-type maltose transport systems, permease component
A3778_RS16195	COG1175	transmembrane transport
A3778_RS16205	COG0366	Alpha amylase catalytic
A3778_RS16210	COG3842	ATPase activity
A3778_RS16215	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A3778_RS16230	COG0366	Alpha amylase catalytic
A3778_RS16260	COG2267	carboxylic ester hydrolase activity
A3778_RS16270	COG1363	Peptidase, m42
A3778_RS16275	COG4166	transmembrane transport
A3778_RS16450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A3778_RS16465	COG3711	transcriptional antiterminator
A3778_RS16470	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A3778_RS16470	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A3778_RS16480	COG1447	Phosphotransferase system cellobiose-specific component IIA
A3778_RS16495	COG1045	serine acetyltransferase
A3778_RS16500	COG0626	cystathionine gamma-synthase activity
A3778_RS16505	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A3778_RS16515	COG2382	esterase
A3778_RS16520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3778_RS16520	COG1263	PTS System
A3778_RS16530	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A3778_RS16540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3778_RS16540	COG1263	PTS System
A3778_RS16540	COG2190	(PTS) system
A3778_RS16570	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A3778_RS16575	COG4821	SIS domain
A3778_RS16590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3778_RS16595	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3778_RS16595	COG3711	transcriptional antiterminator
A3778_RS16605	COG0662	Cupin 2, conserved barrel domain protein
A3778_RS16625	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A3778_RS16640	COG1192	Involved in chromosome partitioning
A3778_RS16840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A3778_RS16855	COG3711	transcriptional antiterminator