locus-tag	class	description
F8M46_RS00010	COG0592	DNA-directed DNA polymerase activity
F8M46_RS00015	COG2501	S4 domain
F8M46_RS00025	COG0187	DNA topoisomerase II activity
F8M46_RS00055	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
F8M46_RS00070	COG0629	single-stranded DNA binding
F8M46_RS00085	COG0693	protein deglycase activity
F8M46_RS00090	COG1271	oxidase subunit
F8M46_RS00095	COG1294	oxidase, subunit
F8M46_RS00120	COG1266	CAAX protease self-immunity
F8M46_RS00160	COG4555	ABC transporter
F8M46_RS00165	COG0004	ammonium transporteR
F8M46_RS00185	COG1136	(ABC) transporter
F8M46_RS00185	COG0577	efflux transmembrane transporter activity
F8M46_RS00195	COG0561	phosphatase activity
F8M46_RS00215	COG0110	maltose O-acetyltransferase activity
F8M46_RS00265	COG3409	Peptidoglycan-binding domain 1 protein
F8M46_RS00280	COG3250	beta-galactosidase activity
F8M46_RS00285	COG1196	nuclear chromosome segregation
F8M46_RS00285	COG4372	Transposase
F8M46_RS00285	COG1511	domain protein
F8M46_RS00290	COG0800	Aldolase
F8M46_RS00295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F8M46_RS00305	COG1312	Catalyzes the dehydration of D-mannonate
F8M46_RS00310	COG0246	Mannitol dehydrogenase
F8M46_RS00345	COG2814	Major facilitator Superfamily
F8M46_RS00365	COG2409	Drug exporters of the RND superfamily
F8M46_RS00365	COG1033	growth of symbiont in host cell
F8M46_RS00370	COG1309	transcriptional regulator
F8M46_RS00380	COG0402	S-adenosylhomocysteine deaminase activity
F8M46_RS00440	COG2217	Heavy metal translocating P-type atpase
F8M46_RS00450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F8M46_RS00480	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8M46_RS00480	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F8M46_RS00480	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F8M46_RS00485	COG0383	alpha-mannosidase activity
F8M46_RS00495	COG2723	6-phospho-beta-galactosidase activity
F8M46_RS00500	COG1940	carbohydrate kinase activity
F8M46_RS00505	COG0159	tryptophan synthase activity
F8M46_RS00560	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
F8M46_RS00585	COG0019	diaminopimelate decarboxylase activity
F8M46_RS00595	COG0527	aspartate kinase activity
F8M46_RS00605	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F8M46_RS00615	COG1396	sequence-specific DNA binding
F8M46_RS00620	COG0494	nUDIX hydrolase
F8M46_RS00645	COG0305	Participates in initiation and elongation during chromosome replication
F8M46_RS00655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F8M46_RS00655	COG1263	PTS System
F8M46_RS00660	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
F8M46_RS00675	COG1309	transcriptional regulator
F8M46_RS00680	COG0577	efflux transmembrane transporter activity
F8M46_RS00680	COG1136	(ABC) transporter
F8M46_RS00705	COG2217	Heavy metal translocating P-type atpase
F8M46_RS00710	COG0640	Transcriptional regulator
F8M46_RS00755	COG3464	Transposase
F8M46_RS00800	COG2814	Major facilitator Superfamily
F8M46_RS00815	COG5002	protein histidine kinase activity
F8M46_RS00815	COG3850	Histidine kinase
F8M46_RS00820	COG0745	RESPONSE REGULATOR receiver
F8M46_RS00825	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F8M46_RS00835	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F8M46_RS00840	COG1447	Phosphotransferase system cellobiose-specific component IIA
F8M46_RS00850	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F8M46_RS00855	COG2723	6-phospho-beta-galactosidase activity
F8M46_RS00860	COG2188	Transcriptional regulator
F8M46_RS00880	COG2252	PERMEase
F8M46_RS00900	COG1116	anion transmembrane transporter activity
F8M46_RS00905	COG4521	taurine ABC transporter
F8M46_RS00910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F8M46_RS00915	COG0446	pyridine nucleotide-disulphide oxidoreductase
F8M46_RS00920	COG2391	methyltransferase activity
F8M46_RS00930	COG0346	lactoylglutathione lyase activity
F8M46_RS00985	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
F8M46_RS01015	COG0191	fructose-bisphosphate aldolase activity
F8M46_RS01035	COG0477	Major facilitator Superfamily
F8M46_RS01040	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
F8M46_RS01045	COG4166	transmembrane transport
F8M46_RS01065	COG1131	(ABC) transporter
F8M46_RS01085	COG1132	(ABC) transporter
F8M46_RS01090	COG1396	sequence-specific DNA binding
F8M46_RS01100	COG0446	pyridine nucleotide-disulphide oxidoreductase
F8M46_RS01150	COG0716	FMN binding
F8M46_RS01165	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F8M46_RS01175	COG2261	transglycosylase associated protein
F8M46_RS01190	COG1302	Protein conserved in bacteria
F8M46_RS01245	COG3442	glutamine amidotransferase
F8M46_RS01270	COG1192	Involved in chromosome partitioning
F8M46_RS01275	COG1475	DNA binding
F8M46_RS01280	COG4481	Protein conserved in bacteria
F8M46_RS01285	COG0012	GTP binding
F8M46_RS01295	COG0516	GMP reductase activity
F8M46_RS01295	COG0517	IMP dehydrogenase activity
F8M46_RS01320	COG1686	Belongs to the peptidase S11 family
F8M46_RS01330	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F8M46_RS01345	COG0656	L-ascorbic acid biosynthetic process
F8M46_RS01350	COG1349	DNA-binding transcription factor activity
F8M46_RS01355	COG2814	Major facilitator Superfamily
F8M46_RS01365	COG1012	belongs to the aldehyde dehydrogenase family
F8M46_RS01370	COG3718	enzyme involved in inositol metabolism
F8M46_RS01375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F8M46_RS01380	COG3962	Belongs to the TPP enzyme family
F8M46_RS01385	COG0673	inositol 2-dehydrogenase activity
F8M46_RS01390	COG0673	inositol 2-dehydrogenase activity
F8M46_RS01400	COG0191	fructose-bisphosphate aldolase activity
F8M46_RS01405	COG1942	4-Oxalocrotonate Tautomerase
F8M46_RS01415	COG1082	Xylose isomerase domain protein TIM barrel
F8M46_RS01420	COG1737	Transcriptional regulator
F8M46_RS01425	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
F8M46_RS01440	COG2610	gluconate transmembrane transporter activity
F8M46_RS01455	COG1215	transferase activity, transferring glycosyl groups
F8M46_RS01465	COG2244	polysaccharide biosynthetic process
F8M46_RS01480	COG1121	(ABC) transporter
F8M46_RS01495	COG2084	Dehydrogenase
F8M46_RS01500	COG1164	Oligoendopeptidase f
F8M46_RS01505	COG1316	TRANSCRIPTIONal
F8M46_RS01510	COG1114	Component of the transport system for branched-chain amino acids
F8M46_RS01525	COG1216	Glycosyl transferase, family 2
F8M46_RS01550	COG0488	(ABC) transporter
F8M46_RS01575	COG3118	belongs to the thioredoxin family
F8M46_RS01610	COG0410	ABC transporter
F8M46_RS01615	COG1694	Mazg nucleotide pyrophosphohydrolase
F8M46_RS01630	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
F8M46_RS01635	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
F8M46_RS01650	COG0446	pyridine nucleotide-disulphide oxidoreductase
F8M46_RS01670	COG2182	Extracellular solute-binding protein
F8M46_RS01680	COG1482	cell wall glycoprotein biosynthetic process
F8M46_RS01685	COG2188	Transcriptional regulator
F8M46_RS01690	COG2222	sugar isomerase
F8M46_RS01710	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F8M46_RS01720	COG3716	PTS system mannose fructose sorbose family IID component
F8M46_RS01725	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F8M46_RS01725	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8M46_RS01740	COG3775	system Galactitol-specific IIC component
F8M46_RS01755	COG3414	Phosphotransferase system galactitol-specific IIB component
F8M46_RS01780	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
F8M46_RS01785	COG0006	proline dipeptidase activity
F8M46_RS01790	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F8M46_RS01795	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F8M46_RS01805	COG1363	Peptidase, m42
F8M46_RS01815	COG2195	Cleaves the N-terminal amino acid of tripeptides
F8M46_RS01820	COG4166	transmembrane transport
F8M46_RS01840	COG1122	ATPase activity
F8M46_RS01850	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
F8M46_RS01870	COG0351	phosphomethylpyrimidine kinase
F8M46_RS01875	COG0531	amino acid
F8M46_RS01885	COG1609	Transcriptional regulator
F8M46_RS01895	COG1598	PFAM Uncharacterised protein family UPF0150
F8M46_RS02000	COG3711	transcriptional antiterminator
F8M46_RS02010	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F8M46_RS02010	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F8M46_RS02010	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8M46_RS02015	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F8M46_RS02025	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F8M46_RS02030	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F8M46_RS02035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8M46_RS02065	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F8M46_RS02070	COG1940	carbohydrate kinase activity
F8M46_RS02075	COG1349	DNA-binding transcription factor activity
F8M46_RS02080	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8M46_RS02080	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F8M46_RS02080	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F8M46_RS02085	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F8M46_RS02090	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F8M46_RS02090	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F8M46_RS02105	COG0191	fructose-bisphosphate aldolase activity
F8M46_RS02115	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8M46_RS02115	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F8M46_RS02130	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F8M46_RS02135	COG1609	Transcriptional regulator
F8M46_RS02140	COG2188	Transcriptional regulator
F8M46_RS02160	COG1735	metal-dependent hydrolase with the TIM-barrel fold
F8M46_RS02165	COG0626	cystathionine gamma-synthase activity
F8M46_RS02170	COG3457	Alanine racemase
F8M46_RS02175	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
F8M46_RS02190	COG1122	ATPase activity
F8M46_RS02200	COG4948	Mandelate Racemase Muconate Lactonizing
F8M46_RS02205	COG1472	Belongs to the glycosyl hydrolase 3 family
F8M46_RS02225	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
F8M46_RS02275	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F8M46_RS02295	COG2801	Transposase and inactivated derivatives
F8M46_RS02300	COG2801	Transposase and inactivated derivatives
F8M46_RS02370	COG2271	Major facilitator Superfamily
F8M46_RS02390	COG3250	beta-galactosidase activity
F8M46_RS02395	COG0531	amino acid
F8M46_RS02400	COG0833	amino acid
F8M46_RS02405	COG2207	Transcriptional regulator
F8M46_RS02415	COG2271	Major facilitator Superfamily
F8M46_RS02420	COG1473	amidohydrolase
F8M46_RS02430	COG1126	abc transporter atp-binding protein
F8M46_RS02435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F8M46_RS02440	COG0765	amino acid transport
F8M46_RS02445	COG0765	amino acid transport
F8M46_RS02470	COG3942	CHAP domain
F8M46_RS02490	COG1136	(ABC) transporter
F8M46_RS02495	COG0446	pyridine nucleotide-disulphide oxidoreductase
F8M46_RS02500	COG0561	phosphatase activity
F8M46_RS02535	COG1464	Belongs to the NlpA lipoprotein family
F8M46_RS02540	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
F8M46_RS02565	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
F8M46_RS02570	COG1461	Dihydroxyacetone kinase
F8M46_RS02575	COG2376	Dihydroxyacetone kinase
F8M46_RS02585	COG1131	(ABC) transporter
F8M46_RS02650	COG2814	Major facilitator Superfamily
F8M46_RS02670	COG0028	Belongs to the TPP enzyme family
F8M46_RS02690	COG4948	Mandelate Racemase Muconate Lactonizing
F8M46_RS02695	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F8M46_RS02705	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
F8M46_RS02715	COG0174	glutamine synthetase
F8M46_RS02725	COG1113	amino acid transport
F8M46_RS02730	COG0789	Transcriptional regulator
F8M46_RS02735	COG0656	L-ascorbic acid biosynthetic process
F8M46_RS02745	COG0604	alcohol dehydrogenase
F8M46_RS02750	COG1733	regulation of RNA biosynthetic process
F8M46_RS02765	COG1131	(ABC) transporter
F8M46_RS02785	COG1131	(ABC) transporter
F8M46_RS02805	COG0308	aminopeptidase N
F8M46_RS02810	COG0531	amino acid
F8M46_RS02845	COG1028	Short-chain dehydrogenase reductase Sdr
F8M46_RS02855	COG2271	Major facilitator Superfamily
F8M46_RS02860	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F8M46_RS02865	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
F8M46_RS02890	COG0626	cystathionine gamma-synthase activity
F8M46_RS02895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F8M46_RS02900	COG0765	amino acid transport
F8M46_RS02910	COG1114	Component of the transport system for branched-chain amino acids
F8M46_RS02975	COG0697	spore germination
F8M46_RS02980	COG3464	Transposase
F8M46_RS02990	COG1131	(ABC) transporter
F8M46_RS03015	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
F8M46_RS03020	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F8M46_RS03030	COG1132	(ABC) transporter
F8M46_RS03035	COG1132	(ABC) transporter
F8M46_RS03045	COG2188	Transcriptional regulator
F8M46_RS03050	COG0366	Alpha amylase catalytic
F8M46_RS03055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F8M46_RS03055	COG2190	(PTS) system
F8M46_RS03055	COG1263	PTS System
F8M46_RS03065	COG0531	amino acid
F8M46_RS03070	COG0039	L-malate dehydrogenase activity
F8M46_RS03075	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F8M46_RS03080	COG1278	Cold shock
F8M46_RS03100	COG0488	(ABC) transporter
F8M46_RS03115	COG0656	L-ascorbic acid biosynthetic process
F8M46_RS03120	COG1113	amino acid transport
F8M46_RS03130	COG0025	NhaP-type Na H and K H
F8M46_RS03160	COG3338	carbonate dehydratase activity
F8M46_RS03180	COG0745	RESPONSE REGULATOR receiver
F8M46_RS03185	COG5002	protein histidine kinase activity
F8M46_RS03190	COG1131	(ABC) transporter
F8M46_RS03205	COG0004	ammonium transporteR
F8M46_RS03215	COG1285	pathogenesis
F8M46_RS03235	COG0488	(ABC) transporter
F8M46_RS03245	COG1573	uracil-dna glycosylase
F8M46_RS03250	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F8M46_RS03255	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F8M46_RS03260	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F8M46_RS03285	COG3711	transcriptional antiterminator
F8M46_RS03290	COG3711	transcriptional antiterminator
F8M46_RS03295	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F8M46_RS03295	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F8M46_RS03305	COG1447	Phosphotransferase system cellobiose-specific component IIA
F8M46_RS03315	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F8M46_RS03325	COG1609	Transcriptional regulator
F8M46_RS03330	COG2017	converts alpha-aldose to the beta-anomer
F8M46_RS03340	COG3775	system Galactitol-specific IIC component
F8M46_RS03370	COG3684	Belongs to the aldolase LacD family
F8M46_RS03385	COG1349	DNA-binding transcription factor activity
F8M46_RS03400	COG0420	3'-5' exonuclease activity
F8M46_RS03405	COG0419	ATPase involved in DNA repair
F8M46_RS03425	COG1194	a g-specific adenine glycosylase
F8M46_RS03435	COG2249	NAD(P)H dehydrogenase (quinone) activity
F8M46_RS03450	COG0351	phosphomethylpyrimidine kinase
F8M46_RS03465	COG2910	NAD(P)H-binding
F8M46_RS03470	COG1472	Belongs to the glycosyl hydrolase 3 family
F8M46_RS03495	COG4120	Belongs to the binding-protein-dependent transport system permease family
F8M46_RS03500	COG1122	ATPase activity
F8M46_RS03505	COG0604	alcohol dehydrogenase
F8M46_RS03525	COG0463	Glycosyl transferase, family 2
F8M46_RS03530	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
F8M46_RS03545	COG0745	RESPONSE REGULATOR receiver
F8M46_RS03550	COG5002	protein histidine kinase activity
F8M46_RS03560	COG2508	Transcriptional regulator
F8M46_RS03565	COG1028	Short-chain dehydrogenase reductase Sdr
F8M46_RS03575	COG0778	Nitroreductase
F8M46_RS03580	COG1304	FMN binding
F8M46_RS03615	COG0604	alcohol dehydrogenase
F8M46_RS03630	COG0628	permease
F8M46_RS03660	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F8M46_RS03670	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
F8M46_RS03675	COG3189	MarR family transcriptional regulator
F8M46_RS03705	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
F8M46_RS03720	COG1132	(ABC) transporter
F8M46_RS03730	COG0105	UTP biosynthetic process
F8M46_RS03740	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F8M46_RS03745	COG2267	carboxylic ester hydrolase activity
F8M46_RS03780	COG2267	carboxylic ester hydrolase activity
F8M46_RS03815	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F8M46_RS03840	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
F8M46_RS03845	COG0343	queuine tRNA-ribosyltransferase activity
F8M46_RS03850	COG1862	Preprotein translocase
F8M46_RS03855	COG1454	alcohol dehydrogenase
F8M46_RS03855	COG1012	belongs to the aldehyde dehydrogenase family
F8M46_RS03865	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
F8M46_RS03870	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F8M46_RS03880	COG4109	DRTGG domain
F8M46_RS03885	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
F8M46_RS03890	COG0513	Belongs to the DEAD box helicase family
F8M46_RS03950	COG3118	belongs to the thioredoxin family
F8M46_RS03960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F8M46_RS03965	COG1696	Membrane protein involved in D-alanine export
F8M46_RS03970	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F8M46_RS03975	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
F8M46_RS03980	COG1719	4-vinyl reductase, 4VR
F8M46_RS03985	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
F8M46_RS03995	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F8M46_RS04010	COG0668	transmembrane transport
F8M46_RS04040	COG1827	regulation of RNA biosynthetic process
F8M46_RS04045	COG0006	proline dipeptidase activity
F8M46_RS04050	COG1609	Transcriptional regulator
F8M46_RS04055	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F8M46_RS04065	COG1011	Hydrolase
F8M46_RS04105	COG0737	Belongs to the 5'-nucleotidase family
F8M46_RS04110	COG4470	Protein conserved in bacteria
F8M46_RS04115	COG0647	UMP catabolic process
F8M46_RS04125	COG0586	Pfam SNARE associated Golgi protein
F8M46_RS04130	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
F8M46_RS04145	COG1098	S1 RNA binding domain
F8M46_RS04295	COG0531	amino acid
F8M46_RS04300	COG0438	transferase activity, transferring glycosyl groups
F8M46_RS04305	COG0438	transferase activity, transferring glycosyl groups
F8M46_RS04315	COG0436	Aminotransferase
F8M46_RS04325	COG1368	sulfuric ester hydrolase activity
F8M46_RS04330	COG0735	belongs to the Fur family
F8M46_RS04375	COG0477	Major facilitator Superfamily
F8M46_RS04385	COG2814	Major facilitator Superfamily
F8M46_RS04395	COG0671	phosphoesterase, PA-phosphatase related
F8M46_RS04410	COG2244	polysaccharide biosynthetic process
F8M46_RS04415	COG1187	pseudouridine synthase activity
F8M46_RS04425	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
F8M46_RS04445	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
F8M46_RS04455	COG3830	Belongs to the UPF0237 family
F8M46_RS04490	COG2357	RelA SpoT domain protein
F8M46_RS04500	COG0564	pseudouridine synthase activity
F8M46_RS04510	COG3142	Participates in the control of copper homeostasis
F8M46_RS04520	COG2706	6-phosphogluconolactonase activity
F8M46_RS04530	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F8M46_RS04560	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
F8M46_RS04580	COG1674	ftsk spoiiie
F8M46_RS04585	COG0612	Peptidase, M16
F8M46_RS04590	COG0612	Peptidase, M16
F8M46_RS04595	COG1028	Short-chain dehydrogenase reductase Sdr
F8M46_RS04600	COG1426	Protein conserved in bacteria
F8M46_RS04605	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F8M46_RS04615	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
F8M46_RS04630	COG1739	Uncharacterized protein family UPF0029
F8M46_RS04635	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
F8M46_RS04670	COG2884	Cell division ATP-binding protein ftsE
F8M46_RS04675	COG2177	Part of the ABC transporter FtsEX involved in
F8M46_RS04685	COG0745	RESPONSE REGULATOR receiver
F8M46_RS04690	COG5002	protein histidine kinase activity
F8M46_RS04700	COG0573	inorganic phosphate transmembrane transporter activity
F8M46_RS04705	COG0581	inorganic phosphate transmembrane transporter activity
F8M46_RS04710	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F8M46_RS04715	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F8M46_RS04720	COG0704	Plays a role in the regulation of phosphate uptake
F8M46_RS04725	COG2801	Transposase and inactivated derivatives
F8M46_RS04745	COG1950	PFAM Membrane protein of
F8M46_RS04755	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F8M46_RS04765	COG0492	ferredoxin-NADP+ reductase activity
F8M46_RS04770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F8M46_RS04785	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F8M46_RS04815	COG0391	Required for morphogenesis under gluconeogenic growth conditions
F8M46_RS04825	COG1846	Transcriptional regulator
F8M46_RS04840	COG2390	Transcriptional regulator
F8M46_RS04885	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F8M46_RS04895	COG0557	exoribonuclease II activity
F8M46_RS04915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F8M46_RS04935	COG3464	Transposase
F8M46_RS04945	COG0395	ABC-type sugar transport system, permease component
F8M46_RS04950	COG1175	transmembrane transport
F8M46_RS04955	COG3842	ATPase activity
F8M46_RS04970	COG0561	phosphatase activity
F8M46_RS04980	COG0280	phosphate acetyltransferase
F8M46_RS04985	COG0802	atpase or kinase
F8M46_RS04990	COG4152	abc transporter atp-binding protein
F8M46_RS04995	COG1668	transmembrane transport
F8M46_RS05005	COG0708	Exodeoxyribonuclease III
F8M46_RS05010	COG3464	Transposase
F8M46_RS05015	COG0812	UDP-N-acetylmuramate dehydrogenase activity
F8M46_RS05025	COG1396	sequence-specific DNA binding
F8M46_RS05025	COG3800	Transcriptional regulator
F8M46_RS05035	COG1176	ABC-type spermidine putrescine transport system, permease component I
F8M46_RS05040	COG1177	transmembrane transport
F8M46_RS05045	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
F8M46_RS05065	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F8M46_RS05070	COG1309	transcriptional regulator
F8M46_RS05105	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F8M46_RS05125	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F8M46_RS05130	COG1459	type II secretion system
F8M46_RS05165	COG0827	DNA restriction-modification system
F8M46_RS05175	COG1113	amino acid transport
F8M46_RS05215	COG0745	RESPONSE REGULATOR receiver
F8M46_RS05220	COG5002	protein histidine kinase activity
F8M46_RS05220	COG3850	Histidine kinase
F8M46_RS05250	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F8M46_RS05320	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F8M46_RS05350	COG2814	Major facilitator Superfamily
F8M46_RS05355	COG0561	phosphatase activity
F8M46_RS05360	COG2326	polyphosphate kinase activity
F8M46_RS05365	COG3590	peptidase
F8M46_RS05420	COG0673	inositol 2-dehydrogenase activity
F8M46_RS05430	COG1447	Phosphotransferase system cellobiose-specific component IIA
F8M46_RS05455	COG0514	ATP-dependent DNA helicase (RecQ)
F8M46_RS05465	COG2309	aminopeptidase activity
F8M46_RS05485	COG1295	ribonuclease BN
F8M46_RS05490	COG0716	FMN binding
F8M46_RS05500	COG0024	Methionine aminopeptidase
F8M46_RS05505	COG0463	Glycosyl transferase, family 2
F8M46_RS05530	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F8M46_RS05540	COG2723	6-phospho-beta-galactosidase activity
F8M46_RS05545	COG2190	(PTS) system
F8M46_RS05545	COG1263	PTS System
F8M46_RS05545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F8M46_RS05550	COG4485	Bacterial membrane protein, YfhO
F8M46_RS05565	COG0463	Glycosyl transferase, family 2
F8M46_RS05575	COG4129	membrane
F8M46_RS05580	COG1278	Cold shock
F8M46_RS05595	COG1705	Flagellar rod assembly protein muramidase FlgJ
F8M46_RS05610	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
F8M46_RS05615	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F8M46_RS05630	COG1368	sulfuric ester hydrolase activity
F8M46_RS05645	COG4975	Glucose uptake
F8M46_RS05655	COG0582	viral genome integration into host DNA
F8M46_RS05700	COG1396	sequence-specific DNA binding
F8M46_RS05780	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
F8M46_RS05955	COG3942	CHAP domain
F8M46_RS05985	COG0590	tRNA wobble adenosine to inosine editing
F8M46_RS06055	COG0588	phosphoglycerate mutase activity
F8M46_RS06080	COG2514	catechol 2,3-dioxygenase activity
F8M46_RS06085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F8M46_RS06090	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
F8M46_RS06095	COG1435	thymidine kinase activity
F8M46_RS06110	COG2890	protein-(glutamine-N5) methyltransferase activity
F8M46_RS06115	COG0009	L-threonylcarbamoyladenylate synthase
F8M46_RS06140	COG0356	it plays a direct role in the translocation of protons across the membrane
F8M46_RS06210	COG1077	Cell shape determining protein MreB Mrl
F8M46_RS06230	COG0772	Belongs to the SEDS family
F8M46_RS06235	COG0509	glycine decarboxylation via glycine cleavage system
F8M46_RS06240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F8M46_RS06245	COG1464	Belongs to the NlpA lipoprotein family
F8M46_RS06270	COG2011	ABC-type metal ion transport system permease component
F8M46_RS06280	COG0719	Fe-S assembly protein
F8M46_RS06285	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F8M46_RS06290	COG0822	iron-sulfur transferase activity
F8M46_RS06295	COG0719	Fe-S assembly protein
F8M46_RS06335	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
F8M46_RS06345	COG1181	Belongs to the D-alanine--D-alanine ligase family
F8M46_RS06345	COG2918	glutathione biosynthetic process
F8M46_RS06360	COG1760	l-serine dehydratase
F8M46_RS06365	COG1760	l-serine dehydratase
F8M46_RS06375	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F8M46_RS06380	COG4221	oxidoreductase activity
F8M46_RS06390	COG1428	Deoxynucleoside kinase
F8M46_RS06400	COG4166	transmembrane transport
F8M46_RS06405	COG2205	protein histidine kinase activity
F8M46_RS06410	COG0745	RESPONSE REGULATOR receiver
F8M46_RS06455	COG1307	EDD domain protein, DegV family
F8M46_RS06465	COG2197	response regulator
F8M46_RS06470	COG4585	Histidine kinase
F8M46_RS06480	COG1131	(ABC) transporter
F8M46_RS06520	COG2183	response to ionizing radiation
F8M46_RS06530	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
F8M46_RS06540	COG3620	sequence-specific DNA binding
F8M46_RS06545	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
F8M46_RS06545	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F8M46_RS06555	COG1956	GAF domain-containing protein
F8M46_RS06560	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
F8M46_RS06570	COG1104	cysteine desulfurase activity
F8M46_RS06580	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
F8M46_RS06585	COG0525	valine-tRNA ligase activity
F8M46_RS06600	COG2003	Belongs to the UPF0758 family
F8M46_RS06605	COG1077	Cell shape determining protein MreB Mrl
F8M46_RS06610	COG1792	Involved in formation and maintenance of cell shape
F8M46_RS06620	COG0850	regulation of cytokinetic process
F8M46_RS06625	COG2894	cell division
F8M46_RS06630	COG0765	amino acid transport
F8M46_RS06635	COG1126	abc transporter atp-binding protein
F8M46_RS06640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F8M46_RS06650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F8M46_RS06675	COG2001	Belongs to the MraZ family
F8M46_RS06690	COG0768	penicillin binding
F8M46_RS06715	COG0849	cell division
F8M46_RS06730	COG0762	integral membrane protein
F8M46_RS06740	COG3599	regulation of cell shape
F8M46_RS06750	COG1278	Cold shock
F8M46_RS06760	COG2814	Major facilitator Superfamily
F8M46_RS06765	COG3853	Toxic anion resistance protein (TelA)
F8M46_RS06790	COG1104	cysteine desulfurase activity
F8M46_RS06805	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F8M46_RS06825	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F8M46_RS06835	COG1597	lipid kinase activity
F8M46_RS06900	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
F8M46_RS06925	COG4476	Belongs to the UPF0223 family
F8M46_RS06930	COG0483	inositol monophosphate 1-phosphatase activity
F8M46_RS06935	COG1217	gtp-binding protein TYPA
F8M46_RS06945	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
F8M46_RS06950	COG4471	UPF0298 protein
F8M46_RS06955	COG0742	ribosomal rna small subunit methyltransferase
F8M46_RS06965	COG3480	Lon protease (S16) C-terminal proteolytic domain
F8M46_RS06975	COG0658	competence protein
F8M46_RS06975	COG2333	competence protein COMEC
F8M46_RS06980	COG1466	dna polymerase III delta subunit
F8M46_RS07040	COG1132	(ABC) transporter
F8M46_RS07050	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F8M46_RS07070	COG0765	amino acid transport
F8M46_RS07075	COG1126	abc transporter atp-binding protein
F8M46_RS07085	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F8M46_RS07085	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F8M46_RS07085	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8M46_RS07090	COG1105	Belongs to the carbohydrate kinase PfkB family
F8M46_RS07095	COG1349	DNA-binding transcription factor activity
F8M46_RS07105	COG2755	lipolytic protein G-D-S-L family
F8M46_RS07105	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
F8M46_RS07115	COG0300	oxidoreductase activity
F8M46_RS07120	COG5416	Lipopolysaccharide assembly protein A domain
F8M46_RS07125	COG0542	response to heat
F8M46_RS07140	COG0737	Belongs to the 5'-nucleotidase family
F8M46_RS07155	COG0587	DNA-directed DNA polymerase activity
F8M46_RS07175	COG2996	Protein conserved in bacteria
F8M46_RS07190	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
F8M46_RS07195	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
F8M46_RS07200	COG1187	pseudouridine synthase activity
F8M46_RS07205	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
F8M46_RS07220	COG0514	ATP-dependent DNA helicase (RecQ)
F8M46_RS07235	COG0539	negative regulation of cytoplasmic translation
F8M46_RS07255	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
F8M46_RS07270	COG0488	(ABC) transporter
F8M46_RS07275	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
F8M46_RS07285	COG1272	protein, Hemolysin III
F8M46_RS07290	COG1307	EDD domain protein, DegV family
F8M46_RS07295	COG2755	lipolytic protein G-D-S-L family
F8M46_RS07300	COG4698	Protein conserved in bacteria
F8M46_RS07305	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F8M46_RS07315	COG0793	Belongs to the peptidase S41A family
F8M46_RS07315	COG3409	Peptidoglycan-binding domain 1 protein
F8M46_RS07345	COG0758	DNA mediated transformation
F8M46_RS07350	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F8M46_RS07375	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
F8M46_RS07390	COG0187	DNA topoisomerase II activity
F8M46_RS07395	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F8M46_RS07405	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
F8M46_RS07410	COG0583	DNA-binding transcription factor activity
F8M46_RS07415	COG1227	inorganic diphosphatase activity
F8M46_RS07420	COG4974	Belongs to the 'phage' integrase family
F8M46_RS07425	COG0577	efflux transmembrane transporter activity
F8M46_RS07430	COG1136	(ABC) transporter
F8M46_RS07435	COG5002	protein histidine kinase activity
F8M46_RS07440	COG0745	RESPONSE REGULATOR receiver
F8M46_RS07460	COG0778	Nitroreductase
F8M46_RS07470	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F8M46_RS07510	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
F8M46_RS07525	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F8M46_RS07535	COG1307	EDD domain protein, DegV family
F8M46_RS07550	COG1293	RNA-binding protein homologous to eukaryotic snRNP
F8M46_RS07565	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F8M46_RS07570	COG0284	orotidine-5'-phosphate decarboxylase activity
F8M46_RS07585	COG0505	Belongs to the CarA family
F8M46_RS07590	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F8M46_RS07600	COG2233	PERMEase
F8M46_RS07605	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
F8M46_RS07615	COG0564	pseudouridine synthase activity
F8M46_RS07620	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F8M46_RS07640	COG0328	RNA-DNA hybrid ribonuclease activity
F8M46_RS07650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F8M46_RS07670	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F8M46_RS07675	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F8M46_RS07680	COG0583	DNA-binding transcription factor activity
F8M46_RS07690	COG3590	peptidase
F8M46_RS07695	COG0095	Lipoate-protein ligase
F8M46_RS07710	COG0116	Belongs to the methyltransferase superfamily
F8M46_RS07740	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F8M46_RS07745	COG2131	deaminase
F8M46_RS07750	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
F8M46_RS07765	COG0436	Aminotransferase
F8M46_RS07780	COG1199	ATP-dependent helicase activity
F8M46_RS07780	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F8M46_RS07795	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
F8M46_RS07810	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
F8M46_RS07810	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F8M46_RS07830	COG2151	metal-sulfur cluster biosynthetic enzyme
F8M46_RS07835	COG1942	4-Oxalocrotonate Tautomerase
F8M46_RS07845	COG2274	protein secretion by the type I secretion system
F8M46_RS07845	COG3271	cysteine-type peptidase activity
F8M46_RS07855	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
F8M46_RS07860	COG2384	SAM-dependent methyltransferase
F8M46_RS07865	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F8M46_RS07870	COG0358	DNA primase activity
F8M46_RS07940	COG5280	Phage tail tape measure protein TP901
F8M46_RS07940	COG3953	SLT domain
F8M46_RS08015	COG1215	transferase activity, transferring glycosyl groups
F8M46_RS08085	COG1381	Involved in DNA repair and RecF pathway recombination
F8M46_RS08095	COG0295	cytidine deaminase activity
F8M46_RS08110	COG1702	phosphate starvation-inducible protein PhoH
F8M46_RS08130	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
F8M46_RS08135	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
F8M46_RS08140	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F8M46_RS08175	COG4991	sh3 domain protein
F8M46_RS08175	COG0860	N-Acetylmuramoyl-L-alanine amidase
F8M46_RS08175	COG3103	Sh3 type 3 domain protein
F8M46_RS08190	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F8M46_RS08205	COG1385	rRNA (uridine-N3-)-methyltransferase activity
F8M46_RS08220	COG2094	Belongs to the DNA glycosylase MPG family
F8M46_RS08250	COG2249	NAD(P)H dehydrogenase (quinone) activity
F8M46_RS08280	COG0438	transferase activity, transferring glycosyl groups
F8M46_RS08330	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
F8M46_RS08340	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
F8M46_RS08340	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
F8M46_RS08380	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F8M46_RS08390	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F8M46_RS08395	COG0196	riboflavin kinase activity
F8M46_RS08405	COG0861	Integral membrane protein TerC family
F8M46_RS08430	COG0195	Participates in both transcription termination and antitermination
F8M46_RS08450	COG0750	zinc metalloprotease
F8M46_RS08455	COG4589	Belongs to the CDS family
F8M46_RS08460	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F8M46_RS08470	COG2801	Transposase and inactivated derivatives
F8M46_RS08505	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
F8M46_RS08510	COG0204	Acyl-transferase
F8M46_RS08515	COG0531	amino acid
F8M46_RS08525	COG1132	(ABC) transporter
F8M46_RS08530	COG1132	(ABC) transporter
F8M46_RS08535	COG3763	UPF0154 protein
F8M46_RS08540	COG4224	UPF0291 protein
F8M46_RS08565	COG1837	Belongs to the UPF0109 family
F8M46_RS08575	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
F8M46_RS08600	COG0552	protein localization to endoplasmic reticulum
F8M46_RS08605	COG1196	nuclear chromosome segregation
F8M46_RS08610	COG0571	ribonuclease III activity
F8M46_RS08620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F8M46_RS08625	COG0601	transmembrane transport
F8M46_RS08630	COG4608	Belongs to the ABC transporter superfamily
F8M46_RS08640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F8M46_RS08650	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
F8M46_RS08655	COG1461	Dihydroxyacetone kinase
F8M46_RS08670	COG1564	THIamine pyrophosphokinase
F8M46_RS08675	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F8M46_RS08680	COG1162	GTPase activity
F8M46_RS08685	COG0515	serine threonine protein kinase
F8M46_RS08685	COG2815	serine threonine protein kinase
F8M46_RS08695	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F8M46_RS08695	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F8M46_RS08705	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
F8M46_RS08710	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
F8M46_RS08720	COG0194	GDP metabolic process
F8M46_RS08735	COG0497	DNA recombination
F8M46_RS08740	COG1438	arginine binding
F8M46_RS08745	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
F8M46_RS08755	COG1722	exodeoxyribonuclease VII activity
F8M46_RS08775	COG1302	Protein conserved in bacteria
F8M46_RS08780	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F8M46_RS08785	COG0006	proline dipeptidase activity
F8M46_RS08790	COG0211	Belongs to the bacterial ribosomal protein bL27 family
F8M46_RS08795	COG2868	ribosomal protein
F8M46_RS08800	COG0261	This protein binds to 23S rRNA in the presence of protein L20
F8M46_RS08830	COG2936	dipeptidyl-peptidase activity
F8M46_RS08840	COG0789	Transcriptional regulator
F8M46_RS08845	COG1982	Orn Lys Arg decarboxylase major
F8M46_RS08850	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
F8M46_RS08865	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F8M46_RS08870	COG1940	carbohydrate kinase activity
F8M46_RS08880	COG0457	Tetratricopeptide repeat
F8M46_RS08880	COG0705	Rhomboid family
F8M46_RS08885	COG0768	penicillin binding
F8M46_RS08890	COG3464	Transposase
F8M46_RS08900	COG4841	protein insertion into membrane
F8M46_RS08905	COG2197	response regulator
F8M46_RS08910	COG4585	Histidine kinase
F8M46_RS08920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F8M46_RS08925	COG0572	uridine kinase
F8M46_RS08930	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F8M46_RS08940	COG0072	phenylalanine-tRNA ligase activity
F8M46_RS08950	COG1733	regulation of RNA biosynthetic process
F8M46_RS08960	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F8M46_RS08970	COG0706	membrane insertase activity
F8M46_RS08975	COG5002	protein histidine kinase activity
F8M46_RS08980	COG0745	RESPONSE REGULATOR receiver
F8M46_RS08985	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
F8M46_RS08990	COG0739	heme binding
F8M46_RS08990	COG0741	lytic transglycosylase activity
F8M46_RS08990	COG1196	nuclear chromosome segregation
F8M46_RS09015	COG2226	methyltransferase
F8M46_RS09020	COG0799	negative regulation of ribosome biogenesis
F8M46_RS09030	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
F8M46_RS09035	COG1534	Rna-binding protein
F8M46_RS09040	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
F8M46_RS09045	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
F8M46_RS09050	COG0346	lactoylglutathione lyase activity
F8M46_RS09060	COG0400	carboxylic ester hydrolase activity
F8M46_RS09085	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
F8M46_RS09130	COG1484	DNA-dependent DNA replication
F8M46_RS09145	COG0237	dephospho-CoA kinase activity
F8M46_RS09150	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F8M46_RS09155	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F8M46_RS09155	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F8M46_RS09165	COG0670	Belongs to the BI1 family
F8M46_RS09200	COG1674	ftsk spoiiie
F8M46_RS09210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F8M46_RS09215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F8M46_RS09240	COG4473	ABC transporter
F8M46_RS09245	COG1131	(ABC) transporter
F8M46_RS09250	COG0537	adenosine 5'-monophosphoramidase activity
F8M46_RS09260	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F8M46_RS09265	COG3481	metal-dependent phosphohydrolase, HD sub domain
F8M46_RS09275	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F8M46_RS09280	COG0564	pseudouridine synthase activity
F8M46_RS09285	COG1438	arginine binding
F8M46_RS09290	COG0018	arginyl-trna synthetase
F8M46_RS09310	COG0167	dihydroorotate dehydrogenase activity
F8M46_RS09325	COG1393	Belongs to the ArsC family
F8M46_RS09330	COG1234	tRNA 3'-trailer cleavage
F8M46_RS09345	COG1136	(ABC) transporter
F8M46_RS09360	COG0745	RESPONSE REGULATOR receiver
F8M46_RS09365	COG0642	Histidine kinase
F8M46_RS09370	COG0602	queuosine metabolic process
F8M46_RS09380	COG3682	Transcriptional regulator
F8M46_RS09385	COG0151	Belongs to the GarS family
F8M46_RS09400	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
F8M46_RS09405	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
F8M46_RS09425	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F8M46_RS09435	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
F8M46_RS09460	COG2814	Major facilitator Superfamily
F8M46_RS09480	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8M46_RS09490	COG0542	response to heat
F8M46_RS09505	COG1253	flavin adenine dinucleotide binding
F8M46_RS09510	COG0628	permease
F8M46_RS09515	COG2153	protein acetylation
F8M46_RS09525	COG3557	Belongs to the UPF0374 family
F8M46_RS09545	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F8M46_RS09555	COG0028	Belongs to the TPP enzyme family
F8M46_RS09565	COG3425	synthase
F8M46_RS09575	COG0183	Belongs to the thiolase family
F8M46_RS09610	COG2017	converts alpha-aldose to the beta-anomer
F8M46_RS09615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F8M46_RS09640	COG3091	SprT-like family
F8M46_RS09645	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
F8M46_RS09650	COG4120	Belongs to the binding-protein-dependent transport system permease family
F8M46_RS09690	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
F8M46_RS09700	COG2188	Transcriptional regulator
F8M46_RS09705	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
F8M46_RS09710	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F8M46_RS09715	COG4946	Tricorn protease homolog
F8M46_RS09715	COG0823	Involved in the tonB-independent uptake of proteins
F8M46_RS09715	COG1506	peptidase
F8M46_RS09740	COG3104	oligopeptide transport
F8M46_RS09745	COG1136	(ABC) transporter
F8M46_RS09745	COG0577	efflux transmembrane transporter activity
F8M46_RS09760	COG2211	Major facilitator Superfamily
F8M46_RS09800	COG2755	lipolytic protein G-D-S-L family
F8M46_RS09800	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
F8M46_RS09885	COG0833	amino acid
F8M46_RS09895	COG3527	Alpha-acetolactate decarboxylase
F8M46_RS09900	COG0028	Belongs to the TPP enzyme family
F8M46_RS09945	COG3177	Filamentation induced by cAMP protein fic
F8M46_RS09950	COG0564	pseudouridine synthase activity
F8M46_RS09970	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
F8M46_RS10025	COG0511	ligase activity, forming carbon-carbon bonds
F8M46_RS10035	COG2851	Citrate transporter
F8M46_RS10070	COG0778	Nitroreductase
F8M46_RS10075	COG1131	(ABC) transporter
F8M46_RS10085	COG1309	transcriptional regulator
F8M46_RS10090	COG2814	Major facilitator Superfamily
F8M46_RS10120	COG1131	(ABC) transporter
F8M46_RS10130	COG4608	Belongs to the ABC transporter superfamily
F8M46_RS10135	COG0444	Belongs to the ABC transporter superfamily
F8M46_RS10145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F8M46_RS10150	COG0601	transmembrane transport
F8M46_RS10155	COG4166	transmembrane transport
F8M46_RS10170	COG1132	(ABC) transporter
F8M46_RS10175	COG1121	(ABC) transporter
F8M46_RS10195	COG5549	protein import
F8M46_RS10195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F8M46_RS10280	COG0519	Catalyzes the synthesis of GMP from XMP
F8M46_RS10300	COG4690	dipeptidase activity
F8M46_RS10305	COG1607	acyl-coa hydrolase
F8M46_RS10310	COG3973	AAA domain
F8M46_RS10330	COG0569	domain protein
F8M46_RS10330	COG0475	glutathione-regulated potassium exporter activity
F8M46_RS10335	COG2267	carboxylic ester hydrolase activity
F8M46_RS10345	COG1914	H( )-stimulated, divalent metal cation uptake system
F8M46_RS10355	COG0588	phosphoglycerate mutase activity
F8M46_RS10360	COG0235	Class ii aldolase
F8M46_RS10370	COG1136	(ABC) transporter
F8M46_RS10375	COG0531	amino acid
F8M46_RS10385	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F8M46_RS10390	COG0726	polysaccharide deacetylase
F8M46_RS10415	COG1091	dTDP-4-dehydrorhamnose reductase activity
F8M46_RS10420	COG1088	dTDP-glucose 4,6-dehydratase activity
F8M46_RS10430	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
F8M46_RS10455	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F8M46_RS10470	COG0765	amino acid transport
F8M46_RS10475	COG0765	amino acid transport
F8M46_RS10480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F8M46_RS10500	COG0735	belongs to the Fur family
F8M46_RS10510	COG0194	GDP metabolic process
F8M46_RS10515	COG0456	acetyltransferase
F8M46_RS10525	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F8M46_RS10550	COG0058	SHG alpha-glucan phosphorylase activity
F8M46_RS10560	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F8M46_RS10570	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F8M46_RS10575	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F8M46_RS10585	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
F8M46_RS10600	COG1393	Belongs to the ArsC family
F8M46_RS10615	COG4464	protein tyrosine phosphatase activity
F8M46_RS10620	COG1316	TRANSCRIPTIONal
F8M46_RS10625	COG1088	dTDP-glucose 4,6-dehydratase activity
F8M46_RS10665	COG0463	Glycosyl transferase, family 2
F8M46_RS10680	COG2244	polysaccharide biosynthetic process
F8M46_RS10685	COG0562	UDP-galactopyranose mutase
F8M46_RS10695	COG0489	protein tyrosine kinase activity
F8M46_RS10720	COG4708	membrane
F8M46_RS10725	COG1028	Short-chain dehydrogenase reductase Sdr
F8M46_RS10745	COG4608	Belongs to the ABC transporter superfamily
F8M46_RS10750	COG0444	Belongs to the ABC transporter superfamily
F8M46_RS10755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F8M46_RS10760	COG0601	transmembrane transport
F8M46_RS10765	COG4166	transmembrane transport
F8M46_RS10770	COG2814	Major facilitator Superfamily
F8M46_RS10775	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F8M46_RS10780	COG1556	Lactate utilization protein
F8M46_RS10785	COG1139	Iron-sulfur cluster binding protein
F8M46_RS10790	COG0247	lactate metabolic process
F8M46_RS10805	COG1447	Phosphotransferase system cellobiose-specific component IIA
F8M46_RS10820	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F8M46_RS10860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F8M46_RS10955	COG0366	Alpha amylase catalytic
F8M46_RS10960	COG1609	Transcriptional regulator
F8M46_RS10975	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F8M46_RS10995	COG0439	Biotin carboxylase
F8M46_RS11005	COG0511	ligase activity, forming carbon-carbon bonds
F8M46_RS11010	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F8M46_RS11015	COG1028	Short-chain dehydrogenase reductase Sdr
F8M46_RS11025	COG2070	2-Nitropropane dioxygenase
F8M46_RS11035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F8M46_RS11045	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F8M46_RS11060	COG1979	alcohol dehydrogenase
F8M46_RS11100	COG1846	Transcriptional regulator
F8M46_RS11105	COG0494	nUDIX hydrolase
F8M46_RS11110	COG0588	phosphoglycerate mutase activity
F8M46_RS11130	COG0628	permease
F8M46_RS11140	COG2246	polysaccharide biosynthetic process
F8M46_RS11145	COG0028	Belongs to the TPP enzyme family
F8M46_RS11200	COG0460	homoserine dehydrogenase
F8M46_RS11205	COG0527	aspartate kinase activity
F8M46_RS11210	COG2268	Band 7 protein
F8M46_RS11240	COG0436	Aminotransferase
F8M46_RS11260	COG0596	Alpha beta hydrolase
F8M46_RS11270	COG1511	domain protein
F8M46_RS11270	COG1511	domain protein
F8M46_RS11290	COG0367	asparagine synthase
F8M46_RS11325	COG0142	geranyltranstransferase activity
F8M46_RS11335	COG4152	abc transporter atp-binding protein
F8M46_RS11350	COG1131	(ABC) transporter
F8M46_RS11360	COG1028	Short-chain dehydrogenase reductase Sdr
F8M46_RS11370	COG1263	PTS System
F8M46_RS11370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F8M46_RS11370	COG2190	(PTS) system
F8M46_RS11380	COG3711	transcriptional antiterminator
F8M46_RS11385	COG1132	(ABC) transporter
F8M46_RS11390	COG1132	(ABC) transporter
F8M46_RS11420	COG1518	maintenance of DNA repeat elements
F8M46_RS11425	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
F8M46_RS11430	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
F8M46_RS11435	COG4988	ABC transporter
F8M46_RS11440	COG1294	oxidase, subunit
F8M46_RS11445	COG1271	oxidase subunit
F8M46_RS11475	COG0697	spore germination
F8M46_RS11480	COG0519	Catalyzes the synthesis of GMP from XMP
F8M46_RS11505	COG2365	Tyrosine phosphatase family
F8M46_RS11510	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
F8M46_RS11520	COG1268	BioY protein
F8M46_RS11550	COG1253	flavin adenine dinucleotide binding
F8M46_RS11565	COG2814	Major facilitator Superfamily
F8M46_RS11595	COG0531	amino acid
F8M46_RS11615	COG1266	CAAX protease self-immunity
F8M46_RS11620	COG1316	TRANSCRIPTIONal
F8M46_RS11630	COG1131	(ABC) transporter
F8M46_RS11635	COG1725	Transcriptional regulator
F8M46_RS11640	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
F8M46_RS11645	COG0488	(ABC) transporter
F8M46_RS11650	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F8M46_RS11660	COG0456	acetyltransferase
F8M46_RS11660	COG1214	PFAM Peptidase M22, glycoprotease
F8M46_RS11665	COG1214	PFAM Peptidase M22, glycoprotease
F8M46_RS11710	COG0470	DNA polymerase III
F8M46_RS11715	COG3870	Protein conserved in bacteria
F8M46_RS11740	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
F8M46_RS11750	COG0590	tRNA wobble adenosine to inosine editing
F8M46_RS11760	COG2813	Specifically methylates the guanine in position
F8M46_RS11765	COG0392	lysyltransferase activity
F8M46_RS11765	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
F8M46_RS11785	COG1609	Transcriptional regulator
F8M46_RS11830	COG0477	Major facilitator Superfamily
F8M46_RS11845	COG0438	transferase activity, transferring glycosyl groups
F8M46_RS11850	COG0438	transferase activity, transferring glycosyl groups
F8M46_RS11855	COG1012	belongs to the aldehyde dehydrogenase family
F8M46_RS11875	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F8M46_RS11885	COG2096	Adenosyltransferase
F8M46_RS11915	COG0250	Participates in transcription elongation, termination and antitermination
F8M46_RS11965	COG4939	FMN-binding domain protein
F8M46_RS12020	COG1131	(ABC) transporter
F8M46_RS12045	COG3688	RNA-binding protein containing a PIN domain
F8M46_RS12050	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F8M46_RS12055	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
F8M46_RS12065	COG1396	sequence-specific DNA binding
F8M46_RS12090	COG4377	Putative membrane peptidase family (DUF2324)
F8M46_RS12100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F8M46_RS12120	COG4956	integral membrane protein (PIN domain superfamily)
F8M46_RS12125	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
F8M46_RS12130	COG0756	dUTP diphosphatase activity
F8M46_RS12145	COG2388	GCN5-related N-acetyl-transferase
F8M46_RS12175	COG1131	(ABC) transporter
F8M46_RS12185	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F8M46_RS12185	COG0574	Belongs to the PEP-utilizing enzyme family
F8M46_RS12190	COG0517	IMP dehydrogenase activity
F8M46_RS12195	COG0588	phosphoglycerate mutase activity
F8M46_RS12210	COG1304	FMN binding
F8M46_RS12310	COG1695	Transcriptional regulator
F8M46_RS12330	COG0667	Aldo Keto reductase
F8M46_RS12355	COG2274	protein secretion by the type I secretion system
F8M46_RS12370	COG3279	Response regulator of the LytR AlgR family
F8M46_RS12450	COG4989	oxidoreductase activity
F8M46_RS12460	COG4221	oxidoreductase activity
F8M46_RS12465	COG1902	pentaerythritol trinitrate reductase activity
F8M46_RS12475	COG0114	fumarate hydratase activity
F8M46_RS12500	COG1914	H( )-stimulated, divalent metal cation uptake system
F8M46_RS12505	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F8M46_RS12515	COG2814	Major facilitator Superfamily
F8M46_RS12545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F8M46_RS12550	COG1121	(ABC) transporter
F8M46_RS12580	COG0803	Belongs to the bacterial solute-binding protein 9 family
F8M46_RS12600	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F8M46_RS12640	COG1116	anion transmembrane transporter activity
F8M46_RS12645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F8M46_RS12680	COG2801	Transposase and inactivated derivatives
F8M46_RS12710	COG1136	(ABC) transporter
F8M46_RS12730	COG0789	Transcriptional regulator
F8M46_RS12800	COG0200	Binds to the 23S rRNA
F8M46_RS12910	COG0450	alkyl hydroperoxide reductase
F8M46_RS12960	COG0542	response to heat
F8M46_RS12965	COG4463	regulation of RNA biosynthetic process
F8M46_RS13035	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
F8M46_RS13040	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F8M46_RS13065	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
F8M46_RS13070	COG0037	tRNA processing
F8M46_RS13075	COG1098	S1 RNA binding domain
F8M46_RS13085	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
F8M46_RS13090	COG2244	polysaccharide biosynthetic process
F8M46_RS13095	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
F8M46_RS13105	COG0039	L-malate dehydrogenase activity
F8M46_RS13120	COG1511	domain protein
F8M46_RS13120	COG1511	domain protein
F8M46_RS13135	COG1376	ErfK ybiS ycfS ynhG family protein
F8M46_RS13140	COG0493	'glutamate synthase
F8M46_RS13145	COG0070	glutamate synthase
F8M46_RS13145	COG0067	glutamate synthase
F8M46_RS13145	COG0069	glutamate synthase activity
F8M46_RS13150	COG4708	membrane
F8M46_RS13165	COG2337	Toxic component of a toxin-antitoxin (TA) module
F8M46_RS13190	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
F8M46_RS13220	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F8M46_RS13230	COG0504	CTP synthase activity
F8M46_RS13235	COG1252	NADH dehydrogenase
F8M46_RS13270	COG0095	Lipoate-protein ligase
F8M46_RS13275	COG1078	dGTPase activity
F8M46_RS13305	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F8M46_RS13310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F8M46_RS13330	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F8M46_RS13335	COG4619	ABC transporter
F8M46_RS13340	COG0390	transport system, permease component
F8M46_RS13350	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
F8M46_RS13355	COG4466	Protein conserved in bacteria
F8M46_RS13370	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F8M46_RS13375	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
F8M46_RS13380	COG0084	hydrolase, TatD family'
F8M46_RS13390	COG3684	Belongs to the aldolase LacD family
F8M46_RS13410	COG3279	Response regulator of the LytR AlgR family
F8M46_RS13415	COG3290	protein histidine kinase activity
F8M46_RS13420	COG1132	(ABC) transporter
F8M46_RS13425	COG1132	(ABC) transporter
F8M46_RS13440	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F8M46_RS13440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F8M46_RS13470	COG1801	Protein of unknown function DUF72
F8M46_RS13490	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
F8M46_RS13505	COG1881	PFAM PEBP family protein
F8M46_RS13515	COG4086	secreted protein
F8M46_RS13520	COG0248	Ppx GppA phosphatase
F8M46_RS13525	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
F8M46_RS13535	COG4989	oxidoreductase activity
F8M46_RS13540	COG2226	methyltransferase
F8M46_RS13550	COG0534	Mate efflux family protein
F8M46_RS13560	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
F8M46_RS13565	COG1704	LemA family
F8M46_RS13590	COG1131	(ABC) transporter
F8M46_RS13600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F8M46_RS13610	COG1174	glycine betaine transport
F8M46_RS13625	COG3973	AAA domain
F8M46_RS13630	COG0583	DNA-binding transcription factor activity
F8M46_RS13660	COG0640	Transcriptional regulator
F8M46_RS13680	COG1418	mRNA catabolic process
F8M46_RS13690	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F8M46_RS13695	COG0667	Aldo Keto reductase
F8M46_RS13720	COG0588	phosphoglycerate mutase activity
F8M46_RS13725	COG0561	phosphatase activity
F8M46_RS13740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F8M46_RS13760	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
F8M46_RS13765	COG1811	Na channel or pump
F8M46_RS13780	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F8M46_RS13780	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8M46_RS13780	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F8M46_RS13785	COG1105	Belongs to the carbohydrate kinase PfkB family
F8M46_RS13795	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F8M46_RS13815	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8M46_RS13815	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F8M46_RS13820	COG3715	PTS system
F8M46_RS13825	COG3716	PTS system mannose fructose sorbose family IID component
F8M46_RS13830	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
F8M46_RS13835	COG0163	prenyltransferase activity
F8M46_RS13860	COG0477	Major facilitator Superfamily
F8M46_RS13870	COG4948	Mandelate Racemase Muconate Lactonizing
F8M46_RS13875	COG3775	system Galactitol-specific IIC component
F8M46_RS13880	COG3414	Phosphotransferase system galactitol-specific IIB component
F8M46_RS13885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8M46_RS13890	COG0800	Aldolase
F8M46_RS13900	COG1447	Phosphotransferase system cellobiose-specific component IIA
F8M46_RS13910	COG2723	6-phospho-beta-galactosidase activity
F8M46_RS13940	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F8M46_RS13945	COG2188	Transcriptional regulator
F8M46_RS13965	COG2814	Major facilitator Superfamily
F8M46_RS13970	COG1070	Carbohydrate kinase
F8M46_RS13980	COG0235	Class ii aldolase
F8M46_RS13985	COG4806	L-rhamnose isomerase
F8M46_RS13990	COG3254	rhamnose metabolic process
F8M46_RS13995	COG1070	Carbohydrate kinase
F8M46_RS14000	COG2814	Major facilitator Superfamily
F8M46_RS14025	COG0366	Alpha amylase catalytic
F8M46_RS14030	COG2801	Transposase and inactivated derivatives
F8M46_RS14055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F8M46_RS14055	COG1263	PTS System
F8M46_RS14070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F8M46_RS14070	COG2190	(PTS) system
F8M46_RS14070	COG1263	PTS System
F8M46_RS14090	COG3964	amidohydrolase
F8M46_RS14135	COG3732	PTS system glucitol sorbitol-specific
F8M46_RS14140	COG3730	PTS system glucitol sorbitol-specific
F8M46_RS14150	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8M46_RS14150	COG3711	transcriptional antiterminator
F8M46_RS14165	COG0561	phosphatase activity
F8M46_RS14170	COG3623	hexulose-6-phosphate isomerase
F8M46_RS14185	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
F8M46_RS14205	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8M46_RS14230	COG1446	asparaginase
F8M46_RS14235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F8M46_RS14240	COG2188	Transcriptional regulator
F8M46_RS14260	COG1070	Carbohydrate kinase
F8M46_RS14265	COG1063	alcohol dehydrogenase
F8M46_RS14270	COG3716	PTS system mannose fructose sorbose family IID component
F8M46_RS14280	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8M46_RS14280	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F8M46_RS14310	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F8M46_RS14315	COG3775	system Galactitol-specific IIC component
F8M46_RS14330	COG0191	fructose-bisphosphate aldolase activity
F8M46_RS14335	COG2188	Transcriptional regulator
F8M46_RS14345	COG1051	belongs to the nudix hydrolase family
F8M46_RS14370	COG1335	isochorismatase
F8M46_RS14375	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
F8M46_RS14380	COG0584	glycerophosphoryl diester phosphodiesterase
F8M46_RS14385	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F8M46_RS14395	COG0395	ABC-type sugar transport system, permease component
F8M46_RS14405	COG3842	ATPase activity
F8M46_RS14420	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F8M46_RS14430	COG1737	Transcriptional regulator
F8M46_RS14435	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F8M46_RS14440	COG3716	PTS system mannose fructose sorbose family IID component
F8M46_RS14460	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
F8M46_RS14465	COG0656	L-ascorbic acid biosynthetic process
F8M46_RS14470	COG0789	Transcriptional regulator
F8M46_RS14485	COG2076	Multidrug Resistance protein
F8M46_RS14515	COG2365	Tyrosine phosphatase family
F8M46_RS14555	COG4166	transmembrane transport
F8M46_RS14570	COG2217	Heavy metal translocating P-type atpase
F8M46_RS14575	COG0071	Belongs to the small heat shock protein (HSP20) family
F8M46_RS14585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F8M46_RS14595	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
F8M46_RS14610	COG5002	protein histidine kinase activity
F8M46_RS14615	COG0745	RESPONSE REGULATOR receiver
F8M46_RS14625	COG0765	amino acid transport
F8M46_RS14650	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F8M46_RS14655	COG2188	Transcriptional regulator
F8M46_RS14660	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F8M46_RS14665	COG1447	Phosphotransferase system cellobiose-specific component IIA
F8M46_RS14695	COG1335	isochorismatase
F8M46_RS14700	COG2814	Major facilitator Superfamily
F8M46_RS14705	COG2807	transmembrane transport
F8M46_RS14710	COG0667	Aldo Keto reductase
F8M46_RS14725	COG3716	PTS system mannose fructose sorbose family IID component
F8M46_RS14730	COG3715	PTS system
F8M46_RS14785	COG3409	Peptidoglycan-binding domain 1 protein
F8M46_RS14795	COG0765	amino acid transport
F8M46_RS14800	COG1126	abc transporter atp-binding protein
F8M46_RS14850	COG4778	phosphonate C-P lyase system protein PhnL
F8M46_RS14855	COG3001	Fructosamine kinase
F8M46_RS14860	COG1126	abc transporter atp-binding protein
F8M46_RS14865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F8M46_RS14870	COG0765	amino acid transport
F8M46_RS14890	COG0714	Associated with various cellular activities
F8M46_RS14900	COG1305	Transglutaminase-like
F8M46_RS14905	COG0438	transferase activity, transferring glycosyl groups
F8M46_RS14915	COG2801	Transposase and inactivated derivatives
F8M46_RS14950	COG3493	citrate carrier protein
F8M46_RS14955	COG3290	protein histidine kinase activity
F8M46_RS14960	COG4565	transcriptional regulatory protein
F8M46_RS15070	COG4695	Portal protein
F8M46_RS15095	COG2261	transglycosylase associated protein
F8M46_RS15105	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F8M46_RS15125	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8M46_RS15130	COG3711	transcriptional antiterminator
F8M46_RS15135	COG2213	PTS system mannitol-specific
F8M46_RS15145	COG0561	phosphatase activity
F8M46_RS15170	COG0577	efflux transmembrane transporter activity
F8M46_RS15170	COG1136	(ABC) transporter
F8M46_RS15190	COG0436	Aminotransferase
F8M46_RS15195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F8M46_RS15210	COG0371	Dehydrogenase
F8M46_RS15225	COG1473	amidohydrolase
F8M46_RS15250	COG1132	(ABC) transporter
F8M46_RS15275	COG0706	membrane insertase activity