locus-tag	class	description
LPA65_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LPA65_RS00010	COG0592	DNA-directed DNA polymerase activity
LPA65_RS00015	COG2501	S4 domain
LPA65_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LPA65_RS00025	COG0187	DNA topoisomerase II activity
LPA65_RS00035	COG0360	Binds together with S18 to 16S ribosomal RNA
LPA65_RS00040	COG0629	single-stranded DNA binding
LPA65_RS00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LPA65_RS00055	COG0359	binds to the 23S rRNA
LPA65_RS00060	COG0305	Participates in initiation and elongation during chromosome replication
LPA65_RS00065	COG2814	Major facilitator Superfamily
LPA65_RS00070	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LPA65_RS00075	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LPA65_RS00080	COG4166	transmembrane transport
LPA65_RS00085	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LPA65_RS00090	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LPA65_RS00095	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LPA65_RS00100	COG0297	glycogen (starch) synthase activity
LPA65_RS00105	COG0058	SHG alpha-glucan phosphorylase activity
LPA65_RS00110	COG0366	Alpha amylase catalytic
LPA65_RS00110	COG3103	Sh3 type 3 domain protein
LPA65_RS00115	COG0561	phosphatase activity
LPA65_RS00120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LPA65_RS00125	COG1554	hydrolase, family 65, central catalytic
LPA65_RS00135	COG1278	Cold shock
LPA65_RS00145	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS00155	COG0745	RESPONSE REGULATOR receiver
LPA65_RS00160	COG5002	protein histidine kinase activity
LPA65_RS00170	COG4853	Protein conserved in bacteria
LPA65_RS00175	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LPA65_RS00180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LPA65_RS00185	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LPA65_RS00200	COG1573	uracil-dna glycosylase
LPA65_RS00235	COG0471	metal ion transport
LPA65_RS00250	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LPA65_RS00255	COG1028	Short-chain dehydrogenase reductase Sdr
LPA65_RS00265	COG0778	Nitroreductase
LPA65_RS00270	COG2508	Transcriptional regulator
LPA65_RS00280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LPA65_RS00285	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
LPA65_RS00300	COG2368	4-hydroxyphenylacetate
LPA65_RS00370	COG2267	carboxylic ester hydrolase activity
LPA65_RS00375	COG3022	response to hydroperoxide
LPA65_RS00385	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS00405	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS00430	COG4166	transmembrane transport
LPA65_RS00455	COG1122	ATPase activity
LPA65_RS00460	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LPA65_RS00465	COG0310	cobalt ion transport
LPA65_RS00470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LPA65_RS00475	COG3875	lactate racemase activity
LPA65_RS00480	COG1691	(AIR) carboxylase
LPA65_RS00485	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
LPA65_RS00490	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
LPA65_RS00495	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LPA65_RS00500	COG1606	tRNA processing
LPA65_RS00510	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
LPA65_RS00515	COG0351	phosphomethylpyrimidine kinase
LPA65_RS00520	COG0352	thiamine-phosphate diphosphorylase activity
LPA65_RS00530	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LPA65_RS00545	COG1113	amino acid transport
LPA65_RS00555	COG2267	carboxylic ester hydrolase activity
LPA65_RS00560	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LPA65_RS00570	COG1983	PspC domain protein
LPA65_RS00615	COG0656	L-ascorbic acid biosynthetic process
LPA65_RS00620	COG0667	Aldo Keto reductase
LPA65_RS00630	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS00645	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS00660	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LPA65_RS00665	COG1122	ATPase activity
LPA65_RS00670	COG4720	Psort location CytoplasmicMembrane, score
LPA65_RS00680	COG2188	Transcriptional regulator
LPA65_RS00705	COG1028	Short-chain dehydrogenase reductase Sdr
LPA65_RS00710	COG1131	(ABC) transporter
LPA65_RS00725	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LPA65_RS00730	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
LPA65_RS00735	COG1309	transcriptional regulator
LPA65_RS00740	COG2376	Dihydroxyacetone kinase
LPA65_RS00745	COG2376	Dihydroxyacetone kinase
LPA65_RS00750	COG1461	Dihydroxyacetone kinase
LPA65_RS00755	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
LPA65_RS00760	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LPA65_RS00765	COG1609	Transcriptional regulator
LPA65_RS00770	COG1609	Transcriptional regulator
LPA65_RS00775	COG0366	Alpha amylase catalytic
LPA65_RS00780	COG2182	Extracellular solute-binding protein
LPA65_RS00785	COG1175	transmembrane transport
LPA65_RS00790	COG3833	ABC-type maltose transport systems, permease component
LPA65_RS00800	COG0366	Alpha amylase catalytic
LPA65_RS00805	COG3842	ATPase activity
LPA65_RS00825	COG2801	Transposase and inactivated derivatives
LPA65_RS00865	COG1063	alcohol dehydrogenase
LPA65_RS00870	COG1757	Na H antiporter
LPA65_RS00885	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS00900	COG4166	transmembrane transport
LPA65_RS00905	COG4166	transmembrane transport
LPA65_RS00915	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LPA65_RS00920	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LPA65_RS00925	COG0406	alpha-ribazole phosphatase activity
LPA65_RS00930	COG0667	Aldo Keto reductase
LPA65_RS00960	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LPA65_RS00965	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LPA65_RS00970	COG0488	(ABC) transporter
LPA65_RS00980	COG4172	Belongs to the ABC transporter superfamily
LPA65_RS00990	COG0386	Belongs to the glutathione peroxidase family
LPA65_RS01000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LPA65_RS01015	COG0363	glucosamine-6-phosphate deaminase activity
LPA65_RS01025	COG2213	PTS system mannitol-specific
LPA65_RS01035	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LPA65_RS01040	COG0246	Mannitol dehydrogenase
LPA65_RS01050	COG3118	belongs to the thioredoxin family
LPA65_RS01080	COG0431	NADPH-dependent FMN reductase
LPA65_RS01085	COG1045	serine acetyltransferase
LPA65_RS01090	COG0626	cystathionine gamma-synthase activity
LPA65_RS01095	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LPA65_RS01120	COG2188	Transcriptional regulator
LPA65_RS01125	COG0366	Alpha amylase catalytic
LPA65_RS01130	COG2190	(PTS) system
LPA65_RS01130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LPA65_RS01130	COG1263	PTS System
LPA65_RS01135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LPA65_RS01135	COG2190	(PTS) system
LPA65_RS01135	COG1263	PTS System
LPA65_RS01145	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LPA65_RS01150	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LPA65_RS01155	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LPA65_RS01160	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LPA65_RS01160	COG0463	Glycosyl transferase, family 2
LPA65_RS01175	COG1959	2 iron, 2 sulfur cluster binding
LPA65_RS01180	COG1309	transcriptional regulator
LPA65_RS01185	COG1914	H( )-stimulated, divalent metal cation uptake system
LPA65_RS01205	COG5002	protein histidine kinase activity
LPA65_RS01210	COG0745	RESPONSE REGULATOR receiver
LPA65_RS01220	COG1737	Transcriptional regulator
LPA65_RS01225	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LPA65_RS01240	COG1316	TRANSCRIPTIONal
LPA65_RS01245	COG0277	FAD linked oxidase domain protein
LPA65_RS01255	COG2357	RelA SpoT domain protein
LPA65_RS01265	COG1033	growth of symbiont in host cell
LPA65_RS01265	COG2409	Drug exporters of the RND superfamily
LPA65_RS01270	COG2818	Glycosylase
LPA65_RS01280	COG0577	efflux transmembrane transporter activity
LPA65_RS01285	COG1136	(ABC) transporter
LPA65_RS01300	COG0741	lytic transglycosylase activity
LPA65_RS01305	COG1388	LysM domain
LPA65_RS01305	COG3942	CHAP domain
LPA65_RS01335	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LPA65_RS01345	COG1846	Transcriptional regulator
LPA65_RS01350	COG1252	NADH dehydrogenase
LPA65_RS01390	COG3842	ATPase activity
LPA65_RS01420	COG1725	Transcriptional regulator
LPA65_RS01425	COG1131	(ABC) transporter
LPA65_RS01435	COG1454	alcohol dehydrogenase
LPA65_RS01435	COG1012	belongs to the aldehyde dehydrogenase family
LPA65_RS01465	COG2801	Transposase and inactivated derivatives
LPA65_RS01490	COG1268	BioY protein
LPA65_RS01515	COG2011	ABC-type metal ion transport system permease component
LPA65_RS01520	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LPA65_RS01525	COG0436	Aminotransferase
LPA65_RS01535	COG1682	transport, permease protein
LPA65_RS01540	COG1134	teichoic acid transport
LPA65_RS01550	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS01560	COG2814	Major facilitator Superfamily
LPA65_RS01565	COG0004	ammonium transporteR
LPA65_RS01585	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LPA65_RS01595	COG3759	membrane
LPA65_RS01600	COG1881	PFAM PEBP family protein
LPA65_RS01630	COG0300	oxidoreductase activity
LPA65_RS01650	COG1125	glycine betaine transport
LPA65_RS01660	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LPA65_RS01670	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LPA65_RS01760	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS01780	COG0561	phosphatase activity
LPA65_RS01785	COG4977	sequence-specific DNA binding
LPA65_RS01790	COG0561	phosphatase activity
LPA65_RS01795	COG1114	Component of the transport system for branched-chain amino acids
LPA65_RS01830	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS01840	COG2274	protein secretion by the type I secretion system
LPA65_RS01880	COG3973	AAA domain
LPA65_RS01885	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LPA65_RS01890	COG0180	Tryptophanyl-tRNA synthetase
LPA65_RS01895	COG2188	Transcriptional regulator
LPA65_RS01900	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LPA65_RS01915	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LPA65_RS01920	COG2723	6-phospho-beta-galactosidase activity
LPA65_RS01925	COG1940	carbohydrate kinase activity
LPA65_RS01935	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LPA65_RS01950	COG0248	Ppx GppA phosphatase
LPA65_RS01965	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LPA65_RS01970	COG1801	Protein of unknown function DUF72
LPA65_RS01980	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LPA65_RS01980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LPA65_RS01985	COG2814	Major facilitator Superfamily
LPA65_RS01990	COG0084	hydrolase, TatD family'
LPA65_RS01995	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
LPA65_RS02000	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LPA65_RS02005	COG4466	Protein conserved in bacteria
LPA65_RS02010	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LPA65_RS02015	COG1073	alpha beta
LPA65_RS02020	COG1121	(ABC) transporter
LPA65_RS02030	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LPA65_RS02035	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LPA65_RS02045	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LPA65_RS02050	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS02070	COG1078	dGTPase activity
LPA65_RS02075	COG0095	Lipoate-protein ligase
LPA65_RS02085	COG3343	RNA polymerase activity
LPA65_RS02090	COG0504	CTP synthase activity
LPA65_RS02095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LPA65_RS02100	COG0814	amino acid
LPA65_RS02110	COG1760	l-serine dehydratase
LPA65_RS02115	COG1760	l-serine dehydratase
LPA65_RS02130	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LPA65_RS02135	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LPA65_RS02140	COG0254	rRNA binding
LPA65_RS02150	COG3764	Sortase (surface protein transpeptidase)
LPA65_RS02155	COG1704	LemA family
LPA65_RS02160	COG0501	Belongs to the peptidase M48B family
LPA65_RS02170	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LPA65_RS02185	COG0736	holo-[acyl-carrier-protein] synthase activity
LPA65_RS02190	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LPA65_RS02195	COG2337	Toxic component of a toxin-antitoxin (TA) module
LPA65_RS02225	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LPA65_RS02230	COG0505	Belongs to the CarA family
LPA65_RS02235	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LPA65_RS02240	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LPA65_RS02245	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LPA65_RS02250	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LPA65_RS02255	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LPA65_RS02270	COG2267	carboxylic ester hydrolase activity
LPA65_RS02285	COG0039	L-malate dehydrogenase activity
LPA65_RS02290	COG0193	aminoacyl-tRNA hydrolase activity
LPA65_RS02295	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LPA65_RS02300	COG2244	polysaccharide biosynthetic process
LPA65_RS02305	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LPA65_RS02315	COG1098	S1 RNA binding domain
LPA65_RS02320	COG0037	tRNA processing
LPA65_RS02335	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LPA65_RS02340	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LPA65_RS02345	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LPA65_RS02385	COG3104	oligopeptide transport
LPA65_RS02435	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LPA65_RS02445	COG2188	Transcriptional regulator
LPA65_RS02455	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LPA65_RS02460	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LPA65_RS02475	COG2183	response to ionizing radiation
LPA65_RS02480	COG3091	SprT-like family
LPA65_RS02485	COG0460	homoserine dehydrogenase
LPA65_RS02490	COG0083	homoserine kinase activity
LPA65_RS02510	COG3715	PTS system
LPA65_RS02515	COG3716	PTS system mannose fructose sorbose family IID component
LPA65_RS02525	COG3933	PFAM sigma-54 factor interaction domain-containing protein
LPA65_RS02525	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
LPA65_RS02530	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LPA65_RS02530	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
LPA65_RS02535	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LPA65_RS02535	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
LPA65_RS02540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LPA65_RS02550	COG0439	Biotin carboxylase
LPA65_RS02560	COG0825	malonyl-CoA metabolic process
LPA65_RS02565	COG1316	TRANSCRIPTIONal
LPA65_RS02575	COG0697	spore germination
LPA65_RS02580	COG0588	phosphoglycerate mutase activity
LPA65_RS02595	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LPA65_RS02605	COG0756	dUTP diphosphatase activity
LPA65_RS02625	COG4956	integral membrane protein (PIN domain superfamily)
LPA65_RS02630	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LPA65_RS02635	COG0215	cysteine-tRNA ligase activity
LPA65_RS02640	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
LPA65_RS02645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LPA65_RS02660	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LPA65_RS02670	COG0250	Participates in transcription elongation, termination and antitermination
LPA65_RS02680	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LPA65_RS02685	COG0081	regulation of translation
LPA65_RS02690	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LPA65_RS02695	COG0222	ribosome binding
LPA65_RS02720	COG1611	Belongs to the LOG family
LPA65_RS02730	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LPA65_RS02735	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LPA65_RS02740	COG2813	Specifically methylates the guanine in position
LPA65_RS02755	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LPA65_RS02760	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LPA65_RS02765	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LPA65_RS02775	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LPA65_RS02780	COG3870	Protein conserved in bacteria
LPA65_RS02785	COG0470	DNA polymerase III
LPA65_RS02790	COG4467	Involved in initiation control of chromosome replication
LPA65_RS02805	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LPA65_RS02820	COG3639	organic phosphonate transmembrane transporter activity
LPA65_RS02830	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LPA65_RS02840	COG1214	PFAM Peptidase M22, glycoprotease
LPA65_RS02845	COG0456	acetyltransferase
LPA65_RS02850	COG0456	acetyltransferase
LPA65_RS02855	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LPA65_RS02865	COG0488	(ABC) transporter
LPA65_RS02870	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
LPA65_RS02875	COG1266	CAAX protease self-immunity
LPA65_RS02880	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LPA65_RS02885	COG0459	protein refolding
LPA65_RS02890	COG0531	amino acid
LPA65_RS02895	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LPA65_RS02900	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LPA65_RS02905	COG1739	Uncharacterized protein family UPF0029
LPA65_RS02910	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
LPA65_RS02915	COG1040	competence protein
LPA65_RS02925	COG0653	protein targeting
LPA65_RS02935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LPA65_RS02940	COG0745	RESPONSE REGULATOR receiver
LPA65_RS02945	COG5002	protein histidine kinase activity
LPA65_RS02955	COG0573	inorganic phosphate transmembrane transporter activity
LPA65_RS02960	COG0581	inorganic phosphate transmembrane transporter activity
LPA65_RS02965	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LPA65_RS02970	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LPA65_RS02975	COG0704	Plays a role in the regulation of phosphate uptake
LPA65_RS02980	COG1983	PspC domain protein
LPA65_RS02985	COG1950	PFAM Membrane protein of
LPA65_RS02990	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LPA65_RS02995	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LPA65_RS03000	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LPA65_RS03005	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LPA65_RS03015	COG0446	pyridine nucleotide-disulphide oxidoreductase
LPA65_RS03020	COG0492	ferredoxin-NADP+ reductase activity
LPA65_RS03025	COG2323	membrane
LPA65_RS03035	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LPA65_RS03045	COG0446	pyridine nucleotide-disulphide oxidoreductase
LPA65_RS03055	COG2814	Major facilitator Superfamily
LPA65_RS03065	COG0556	nucleotide-excision repair
LPA65_RS03070	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LPA65_RS03075	COG1854	S-ribosylhomocysteine lyase activity
LPA65_RS03080	COG0137	argininosuccinate synthase activity
LPA65_RS03085	COG0165	Argininosuccinate lyase
LPA65_RS03095	COG1660	Displays ATPase and GTPase activities
LPA65_RS03105	COG1481	regulation of sporulation
LPA65_RS03115	COG4166	transmembrane transport
LPA65_RS03120	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LPA65_RS03125	COG0740	serine-type endopeptidase activity
LPA65_RS03135	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LPA65_RS03140	COG2390	Transcriptional regulator
LPA65_RS03150	COG0126	phosphoglycerate kinase activity
LPA65_RS03155	COG0149	triose-phosphate isomerase activity
LPA65_RS03160	COG0148	phosphopyruvate hydratase activity
LPA65_RS03175	COG0038	chloride channel
LPA65_RS03180	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LPA65_RS03190	COG0557	exoribonuclease II activity
LPA65_RS03195	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LPA65_RS03205	COG0765	amino acid transport
LPA65_RS03210	COG1126	abc transporter atp-binding protein
LPA65_RS03220	COG0561	phosphatase activity
LPA65_RS03225	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LPA65_RS03230	COG0280	phosphate acetyltransferase
LPA65_RS03235	COG0802	atpase or kinase
LPA65_RS03250	COG0708	Exodeoxyribonuclease III
LPA65_RS03260	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LPA65_RS03265	COG0025	NhaP-type Na H and K H
LPA65_RS03290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LPA65_RS03295	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LPA65_RS03305	COG0561	phosphatase activity
LPA65_RS03315	COG2017	converts alpha-aldose to the beta-anomer
LPA65_RS03330	COG0778	Nitroreductase
LPA65_RS03340	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LPA65_RS03355	COG1393	Belongs to the ArsC family
LPA65_RS03375	COG0248	Ppx GppA phosphatase
LPA65_RS03380	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LPA65_RS03390	COG3475	LICD family
LPA65_RS03405	COG2252	PERMEase
LPA65_RS03410	COG0028	Belongs to the TPP enzyme family
LPA65_RS03415	COG0196	riboflavin kinase activity
LPA65_RS03420	COG0028	Belongs to the TPP enzyme family
LPA65_RS03425	COG2267	carboxylic ester hydrolase activity
LPA65_RS03435	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LPA65_RS03435	COG2755	lipolytic protein G-D-S-L family
LPA65_RS03440	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS03445	COG2936	dipeptidyl-peptidase activity
LPA65_RS03460	COG0531	amino acid
LPA65_RS03485	COG0194	GDP metabolic process
LPA65_RS03490	COG0735	belongs to the Fur family
LPA65_RS03505	COG0546	phosphoglycolate phosphatase activity
LPA65_RS03510	COG0436	Aminotransferase
LPA65_RS03515	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LPA65_RS03535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LPA65_RS03540	COG0765	amino acid transport
LPA65_RS03545	COG0765	amino acid transport
LPA65_RS03550	COG0531	amino acid
LPA65_RS03555	COG1846	Transcriptional regulator
LPA65_RS03585	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LPA65_RS03595	COG2076	Multidrug Resistance protein
LPA65_RS03610	COG0588	phosphoglycerate mutase activity
LPA65_RS03615	COG0475	glutathione-regulated potassium exporter activity
LPA65_RS03615	COG0569	domain protein
LPA65_RS03625	COG3711	transcriptional antiterminator
LPA65_RS03630	COG1263	PTS System
LPA65_RS03630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LPA65_RS03630	COG2190	(PTS) system
LPA65_RS03635	COG2723	6-phospho-beta-galactosidase activity
LPA65_RS03640	COG0586	Pfam SNARE associated Golgi protein
LPA65_RS03645	COG3973	AAA domain
LPA65_RS03650	COG2070	2-Nitropropane dioxygenase
LPA65_RS03655	COG1072	(Pantothenic acid kinase))
LPA65_RS03660	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LPA65_RS03660	COG0519	Catalyzes the synthesis of GMP from XMP
LPA65_RS03670	COG1396	sequence-specific DNA binding
LPA65_RS03675	COG1266	CAAX protease self-immunity
LPA65_RS03690	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LPA65_RS03690	COG2755	lipolytic protein G-D-S-L family
LPA65_RS03695	COG2261	transglycosylase associated protein
LPA65_RS03710	COG1302	Protein conserved in bacteria
LPA65_RS03730	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS03745	COG0308	aminopeptidase N
LPA65_RS03750	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LPA65_RS03765	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS03805	COG0572	uridine kinase
LPA65_RS03825	COG1053	succinate dehydrogenase
LPA65_RS03835	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LPA65_RS03840	COG0017	Asparaginyl-tRNA synthetase
LPA65_RS03845	COG2502	aspartate--ammonia ligase
LPA65_RS03850	COG4690	dipeptidase activity
LPA65_RS03870	COG0514	ATP-dependent DNA helicase (RecQ)
LPA65_RS03875	COG0564	pseudouridine synthase activity
LPA65_RS03880	COG0640	Transcriptional regulator
LPA65_RS03930	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LPA65_RS03935	COG0527	aspartate kinase activity
LPA65_RS03940	COG0367	asparagine synthase
LPA65_RS03980	COG2814	Major facilitator Superfamily
LPA65_RS04000	COG1278	Cold shock
LPA65_RS04015	COG1316	TRANSCRIPTIONal
LPA65_RS04035	COG1959	2 iron, 2 sulfur cluster binding
LPA65_RS04040	COG0028	Belongs to the TPP enzyme family
LPA65_RS04045	COG0833	amino acid
LPA65_RS04055	COG1428	Deoxynucleoside kinase
LPA65_RS04060	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LPA65_RS04100	COG4463	regulation of RNA biosynthetic process
LPA65_RS04105	COG0542	response to heat
LPA65_RS04115	COG0085	RNA polymerase activity
LPA65_RS04120	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LPA65_RS04125	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LPA65_RS04130	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LPA65_RS04135	COG0049	tRNA binding
LPA65_RS04140	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LPA65_RS04150	COG0051	transcription antitermination factor activity, RNA binding
LPA65_RS04155	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LPA65_RS04160	COG0088	Forms part of the polypeptide exit tunnel
LPA65_RS04165	COG0089	rRNA binding
LPA65_RS04170	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LPA65_RS04175	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LPA65_RS04180	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LPA65_RS04185	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LPA65_RS04190	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LPA65_RS04195	COG0255	Belongs to the universal ribosomal protein uL29 family
LPA65_RS04200	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LPA65_RS04205	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LPA65_RS04210	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LPA65_RS04215	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LPA65_RS04220	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LPA65_RS04225	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LPA65_RS04230	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LPA65_RS04235	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LPA65_RS04240	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LPA65_RS04245	COG1841	ribosomal large subunit assembly
LPA65_RS04250	COG0200	Binds to the 23S rRNA
LPA65_RS04260	COG0563	adenylate kinase activity
LPA65_RS04265	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LPA65_RS04270	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LPA65_RS04275	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LPA65_RS04280	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LPA65_RS04285	COG0202	RNA polymerase activity
LPA65_RS04290	COG0203	ribosomal protein L17
LPA65_RS04295	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS04310	COG4372	Transposase
LPA65_RS04335	COG4939	FMN-binding domain protein
LPA65_RS04345	COG1122	ATPase activity
LPA65_RS04350	COG1122	ATPase activity
LPA65_RS04360	COG0101	tRNA pseudouridine synthase activity
LPA65_RS04365	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LPA65_RS04370	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LPA65_RS04385	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LPA65_RS04390	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LPA65_RS04395	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
LPA65_RS04400	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LPA65_RS04405	COG2151	metal-sulfur cluster biosynthetic enzyme
LPA65_RS04410	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
LPA65_RS04420	COG4977	sequence-specific DNA binding
LPA65_RS04420	COG1917	Cupin 2, conserved barrel domain protein
LPA65_RS04425	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
LPA65_RS04430	COG1121	(ABC) transporter
LPA65_RS04435	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LPA65_RS04440	COG0803	Belongs to the bacterial solute-binding protein 9 family
LPA65_RS04450	COG0039	L-malate dehydrogenase activity
LPA65_RS04455	COG0471	metal ion transport
LPA65_RS04475	COG3052	prosthetic group binding
LPA65_RS04495	COG0114	fumarate hydratase activity
LPA65_RS04500	COG1053	succinate dehydrogenase
LPA65_RS04510	COG0583	DNA-binding transcription factor activity
LPA65_RS04515	COG0583	DNA-binding transcription factor activity
LPA65_RS04520	COG0281	malic enzyme
LPA65_RS04530	COG0531	amino acid
LPA65_RS04535	COG4684	Psort location CytoplasmicMembrane, score
LPA65_RS04550	COG1271	oxidase subunit
LPA65_RS04555	COG1294	oxidase, subunit
LPA65_RS04560	COG4988	ABC transporter
LPA65_RS04565	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LPA65_RS04580	COG0142	geranyltranstransferase activity
LPA65_RS04600	COG1705	Flagellar rod assembly protein muramidase FlgJ
LPA65_RS04605	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LPA65_RS04610	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
LPA65_RS04615	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LPA65_RS04630	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LPA65_RS04635	COG4851	CamS sex pheromone cAM373 precursor
LPA65_RS04640	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LPA65_RS04645	COG0154	amidase activity
LPA65_RS04650	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LPA65_RS04655	COG1597	lipid kinase activity
LPA65_RS04660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LPA65_RS04685	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LPA65_RS04695	COG1737	Transcriptional regulator
LPA65_RS04710	COG1278	Cold shock
LPA65_RS04715	COG0673	inositol 2-dehydrogenase activity
LPA65_RS04720	COG0513	Belongs to the DEAD box helicase family
LPA65_RS04735	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LPA65_RS04760	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LPA65_RS04770	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LPA65_RS04780	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LPA65_RS04785	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS04795	COG2801	Transposase and inactivated derivatives
LPA65_RS04810	COG0562	UDP-galactopyranose mutase
LPA65_RS04850	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS04860	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LPA65_RS04895	COG2137	regulation of response to DNA damage stimulus
LPA65_RS04900	COG3557	Belongs to the UPF0374 family
LPA65_RS04920	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LPA65_RS04930	COG0628	permease
LPA65_RS04935	COG2610	gluconate transmembrane transporter activity
LPA65_RS04940	COG1070	Carbohydrate kinase
LPA65_RS04945	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LPA65_RS04950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LPA65_RS04955	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LPA65_RS04990	COG4166	transmembrane transport
LPA65_RS04995	COG0601	transmembrane transport
LPA65_RS05000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LPA65_RS05005	COG0444	Belongs to the ABC transporter superfamily
LPA65_RS05010	COG4608	Belongs to the ABC transporter superfamily
LPA65_RS05020	COG0582	viral genome integration into host DNA
LPA65_RS05025	COG0542	response to heat
LPA65_RS05045	COG0438	transferase activity, transferring glycosyl groups
LPA65_RS05050	COG0438	transferase activity, transferring glycosyl groups
LPA65_RS05060	COG1686	Belongs to the peptidase S11 family
LPA65_RS05065	COG0436	Aminotransferase
LPA65_RS05070	COG4703	Protein of unknown function (DUF1797)
LPA65_RS05075	COG1368	sulfuric ester hydrolase activity
LPA65_RS05185	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LPA65_RS05200	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LPA65_RS05205	COG0833	amino acid
LPA65_RS05210	COG2040	homocysteine
LPA65_RS05215	COG0438	transferase activity, transferring glycosyl groups
LPA65_RS05225	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LPA65_RS05230	COG0477	Major facilitator Superfamily
LPA65_RS05245	COG0438	transferase activity, transferring glycosyl groups
LPA65_RS05260	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
LPA65_RS05270	COG0495	leucyl-tRNA aminoacylation
LPA65_RS05275	COG2244	polysaccharide biosynthetic process
LPA65_RS05280	COG1187	pseudouridine synthase activity
LPA65_RS05285	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LPA65_RS05290	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LPA65_RS05300	COG3842	ATPase activity
LPA65_RS05305	COG1175	transmembrane transport
LPA65_RS05320	COG0584	glycerophosphoryl diester phosphodiesterase
LPA65_RS05325	COG1428	Deoxynucleoside kinase
LPA65_RS05330	COG1970	mechanosensitive ion channel activity
LPA65_RS05335	COG1511	domain protein
LPA65_RS05365	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LPA65_RS05370	COG0561	phosphatase activity
LPA65_RS05395	COG3279	Response regulator of the LytR AlgR family
LPA65_RS05415	COG1846	Transcriptional regulator
LPA65_RS05430	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LPA65_RS05470	COG0646	methionine synthase
LPA65_RS05470	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LPA65_RS05475	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LPA65_RS05485	COG2046	Belongs to the sulfate adenylyltransferase family
LPA65_RS05490	COG0529	Catalyzes the synthesis of activated sulfate
LPA65_RS05495	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LPA65_RS05505	COG0471	metal ion transport
LPA65_RS05505	COG3273	potassium ion transport
LPA65_RS05530	COG2153	protein acetylation
LPA65_RS05535	COG0018	arginyl-trna synthetase
LPA65_RS05545	COG1136	(ABC) transporter
LPA65_RS05545	COG0577	efflux transmembrane transporter activity
LPA65_RS05565	COG1447	Phosphotransferase system cellobiose-specific component IIA
LPA65_RS05570	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LPA65_RS05575	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LPA65_RS05590	COG1376	ErfK ybiS ycfS ynhG family protein
LPA65_RS05595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LPA65_RS05600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LPA65_RS05610	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LPA65_RS05615	COG1438	arginine binding
LPA65_RS05625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LPA65_RS05630	COG3679	Belongs to the UPF0342 family
LPA65_RS05635	COG0420	3'-5' exonuclease activity
LPA65_RS05640	COG4717	serine-type aminopeptidase activity
LPA65_RS05645	COG3481	metal-dependent phosphohydrolase, HD sub domain
LPA65_RS05660	COG0583	DNA-binding transcription factor activity
LPA65_RS05670	COG1053	succinate dehydrogenase
LPA65_RS05670	COG0431	NADPH-dependent FMN reductase
LPA65_RS05670	COG3976	FMN-binding domain protein
LPA65_RS05690	COG0463	Glycosyl transferase, family 2
LPA65_RS05710	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LPA65_RS05710	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LPA65_RS05715	COG0307	riboflavin synthase, alpha
LPA65_RS05720	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LPA65_RS05720	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LPA65_RS05725	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LPA65_RS05750	COG0446	pyridine nucleotide-disulphide oxidoreductase
LPA65_RS05785	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LPA65_RS05795	COG0537	adenosine 5'-monophosphoramidase activity
LPA65_RS05800	COG1131	(ABC) transporter
LPA65_RS05805	COG4473	ABC transporter
LPA65_RS05810	COG0510	thiamine kinase activity
LPA65_RS05815	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LPA65_RS05825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LPA65_RS05830	COG1674	ftsk spoiiie
LPA65_RS05835	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LPA65_RS05860	COG0719	Fe-S assembly protein
LPA65_RS05865	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LPA65_RS05875	COG0719	Fe-S assembly protein
LPA65_RS05880	COG2151	metal-sulfur cluster biosynthetic enzyme
LPA65_RS05895	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LPA65_RS05895	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LPA65_RS05900	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LPA65_RS05905	COG0237	dephospho-CoA kinase activity
LPA65_RS05910	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LPA65_RS05915	COG3611	Membrane attachment protein
LPA65_RS05920	COG1484	DNA-dependent DNA replication
LPA65_RS05925	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LPA65_RS05930	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LPA65_RS05935	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LPA65_RS05940	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LPA65_RS05950	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LPA65_RS05965	COG1518	maintenance of DNA repeat elements
LPA65_RS05970	COG2176	DNA-directed DNA polymerase activity
LPA65_RS05990	COG1857	crispr-associated protein
LPA65_RS06005	COG1215	transferase activity, transferring glycosyl groups
LPA65_RS06020	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LPA65_RS06025	COG1534	Rna-binding protein
LPA65_RS06030	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LPA65_RS06035	COG1713	HD superfamily hydrolase involved in NAD metabolism
LPA65_RS06040	COG0799	negative regulation of ribosome biogenesis
LPA65_RS06045	COG2226	methyltransferase
LPA65_RS06050	COG1323	Belongs to the UPF0348 family
LPA65_RS06060	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LPA65_RS06075	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LPA65_RS06080	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LPA65_RS06085	COG0745	RESPONSE REGULATOR receiver
LPA65_RS06090	COG5002	protein histidine kinase activity
LPA65_RS06100	COG0419	ATPase involved in DNA repair
LPA65_RS06105	COG0420	3'-5' exonuclease activity
LPA65_RS06110	COG4166	transmembrane transport
LPA65_RS06125	COG0706	membrane insertase activity
LPA65_RS06130	COG1254	Belongs to the acylphosphatase family
LPA65_RS06135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LPA65_RS06145	COG1733	regulation of RNA biosynthetic process
LPA65_RS06150	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LPA65_RS06155	COG0072	phenylalanine-tRNA ligase activity
LPA65_RS06155	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LPA65_RS06160	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LPA65_RS06165	COG0572	uridine kinase
LPA65_RS06170	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LPA65_RS06190	COG4841	protein insertion into membrane
LPA65_RS06200	COG0768	penicillin binding
LPA65_RS06205	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LPA65_RS06210	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LPA65_RS06215	COG0705	Rhomboid family
LPA65_RS06215	COG0457	Tetratricopeptide repeat
LPA65_RS06225	COG1940	carbohydrate kinase activity
LPA65_RS06245	COG0584	glycerophosphoryl diester phosphodiesterase
LPA65_RS06250	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LPA65_RS06255	COG0789	Transcriptional regulator
LPA65_RS06315	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LPA65_RS06325	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LPA65_RS06330	COG0006	proline dipeptidase activity
LPA65_RS06335	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LPA65_RS06340	COG1302	Protein conserved in bacteria
LPA65_RS06345	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LPA65_RS06350	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LPA65_RS06355	COG1570	exodeoxyribonuclease VII activity
LPA65_RS06360	COG1722	exodeoxyribonuclease VII activity
LPA65_RS06365	COG0142	geranyltranstransferase activity
LPA65_RS06370	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
LPA65_RS06375	COG1438	arginine binding
LPA65_RS06380	COG0497	DNA recombination
LPA65_RS06395	COG1732	Glycine betaine
LPA65_RS06410	COG0194	GDP metabolic process
LPA65_RS06415	COG1758	RNA polymerase activity
LPA65_RS06420	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LPA65_RS06425	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LPA65_RS06430	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LPA65_RS06435	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LPA65_RS06435	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LPA65_RS06440	COG0631	protein serine/threonine phosphatase activity
LPA65_RS06445	COG0515	serine threonine protein kinase
LPA65_RS06445	COG2815	serine threonine protein kinase
LPA65_RS06450	COG1162	GTPase activity
LPA65_RS06455	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LPA65_RS06460	COG1564	THIamine pyrophosphokinase
LPA65_RS06465	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LPA65_RS06470	COG1302	Protein conserved in bacteria
LPA65_RS06475	COG1461	Dihydroxyacetone kinase
LPA65_RS06480	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LPA65_RS06485	COG0416	fatty acid biosynthetic process
LPA65_RS06490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LPA65_RS06495	COG0571	ribonuclease III activity
LPA65_RS06500	COG1196	nuclear chromosome segregation
LPA65_RS06505	COG0552	protein localization to endoplasmic reticulum
LPA65_RS06510	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
LPA65_RS06515	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LPA65_RS06520	COG0228	four-way junction DNA binding
LPA65_RS06525	COG1837	Belongs to the UPF0109 family
LPA65_RS06530	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LPA65_RS06535	COG0336	Belongs to the RNA methyltransferase TrmD family
LPA65_RS06540	COG0335	large ribosomal subunit rRNA binding
LPA65_RS06570	COG1131	(ABC) transporter
LPA65_RS06585	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LPA65_RS06585	COG0512	Glutamine amidotransferase of anthranilate synthase
LPA65_RS06590	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LPA65_RS06595	COG0134	indole-3-glycerol-phosphate synthase activity
LPA65_RS06600	COG0135	phosphoribosylanthranilate isomerase activity
LPA65_RS06605	COG0133	tryptophan synthase activity
LPA65_RS06610	COG0159	tryptophan synthase activity
LPA65_RS06625	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LPA65_RS06635	COG1473	amidohydrolase
LPA65_RS06640	COG1063	alcohol dehydrogenase
LPA65_RS06650	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LPA65_RS06655	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LPA65_RS06660	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LPA65_RS06665	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LPA65_RS06670	COG1028	Short-chain dehydrogenase reductase Sdr
LPA65_RS06675	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LPA65_RS06690	COG0439	Biotin carboxylase
LPA65_RS06705	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LPA65_RS06720	COG1811	Na channel or pump
LPA65_RS06725	COG0583	DNA-binding transcription factor activity
LPA65_RS06730	COG1607	acyl-coa hydrolase
LPA65_RS06735	COG1162	GTPase activity
LPA65_RS06745	COG0477	Major facilitator Superfamily
LPA65_RS06765	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS06770	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LPA65_RS06790	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
LPA65_RS06800	COG3152	Membrane
LPA65_RS06805	COG1597	lipid kinase activity
LPA65_RS06820	COG2261	transglycosylase associated protein
LPA65_RS06825	COG3237	CsbD-like
LPA65_RS06840	COG1942	4-Oxalocrotonate Tautomerase
LPA65_RS06880	COG0531	amino acid
LPA65_RS06885	COG0561	phosphatase activity
LPA65_RS06890	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
LPA65_RS06890	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LPA65_RS06910	COG2017	converts alpha-aldose to the beta-anomer
LPA65_RS06915	COG1304	FMN binding
LPA65_RS06940	COG1199	ATP-dependent helicase activity
LPA65_RS06940	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LPA65_RS06955	COG0017	Asparaginyl-tRNA synthetase
LPA65_RS06965	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LPA65_RS06970	COG2011	ABC-type metal ion transport system permease component
LPA65_RS06975	COG1464	Belongs to the NlpA lipoprotein family
LPA65_RS07010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LPA65_RS07015	COG3331	DNA recombination
LPA65_RS07020	COG4474	Belongs to the UPF0398 family
LPA65_RS07025	COG3599	regulation of cell shape
LPA65_RS07035	COG0116	Belongs to the methyltransferase superfamily
LPA65_RS07040	COG1073	alpha beta
LPA65_RS07050	COG1216	Glycosyl transferase, family 2
LPA65_RS07070	COG1619	proteins homologs of microcin C7 resistance protein MccF
LPA65_RS07095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LPA65_RS07110	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LPA65_RS07115	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LPA65_RS07120	COG0564	pseudouridine synthase activity
LPA65_RS07125	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LPA65_RS07130	COG0505	Belongs to the CarA family
LPA65_RS07135	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LPA65_RS07145	COG5646	InterPro IPR014922
LPA65_RS07170	COG1131	(ABC) transporter
LPA65_RS07180	COG1293	RNA-binding protein homologous to eukaryotic snRNP
LPA65_RS07190	COG1307	EDD domain protein, DegV family
LPA65_RS07250	COG1113	amino acid transport
LPA65_RS07265	COG1620	l-lactate permease
LPA65_RS07275	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LPA65_RS07285	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LPA65_RS07300	COG1846	Transcriptional regulator
LPA65_RS07305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LPA65_RS07335	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LPA65_RS07340	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LPA65_RS07345	COG1227	inorganic diphosphatase activity
LPA65_RS07350	COG0583	DNA-binding transcription factor activity
LPA65_RS07360	COG0187	DNA topoisomerase II activity
LPA65_RS07365	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LPA65_RS07375	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LPA65_RS07380	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LPA65_RS07385	COG4974	Belongs to the 'phage' integrase family
LPA65_RS07390	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
LPA65_RS07395	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LPA65_RS07400	COG0758	DNA mediated transformation
LPA65_RS07405	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LPA65_RS07410	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LPA65_RS07420	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LPA65_RS07425	COG0583	DNA-binding transcription factor activity
LPA65_RS07440	COG2814	Major facilitator Superfamily
LPA65_RS07445	COG3409	Peptidoglycan-binding domain 1 protein
LPA65_RS07445	COG0793	Belongs to the peptidase S41A family
LPA65_RS07450	COG4479	Belongs to the UPF0346 family
LPA65_RS07455	COG4698	Protein conserved in bacteria
LPA65_RS07460	COG2755	lipolytic protein G-D-S-L family
LPA65_RS07465	COG1307	EDD domain protein, DegV family
LPA65_RS07470	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LPA65_RS07475	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LPA65_RS07480	COG0488	(ABC) transporter
LPA65_RS07490	COG0617	tRNA 3'-terminal CCA addition
LPA65_RS07495	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LPA65_RS07500	COG0561	phosphatase activity
LPA65_RS07505	COG0457	Tetratricopeptide repeat
LPA65_RS07520	COG1160	GTP binding
LPA65_RS07525	COG0539	negative regulation of cytoplasmic translation
LPA65_RS07530	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LPA65_RS07540	COG0514	ATP-dependent DNA helicase (RecQ)
LPA65_RS07555	COG1187	pseudouridine synthase activity
LPA65_RS07560	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LPA65_RS07565	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LPA65_RS07575	COG4974	Belongs to the 'phage' integrase family
LPA65_RS07580	COG2996	Protein conserved in bacteria
LPA65_RS07600	COG0205	6-phosphofructokinase activity
LPA65_RS07605	COG0587	DNA-directed DNA polymerase activity
LPA65_RS07615	COG0542	response to heat
LPA65_RS07625	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LPA65_RS07630	COG2384	SAM-dependent methyltransferase
LPA65_RS07655	COG0574	Belongs to the PEP-utilizing enzyme family
LPA65_RS07655	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LPA65_RS07665	COG1846	Transcriptional regulator
LPA65_RS07690	COG1733	regulation of RNA biosynthetic process
LPA65_RS07705	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LPA65_RS07710	COG0446	pyridine nucleotide-disulphide oxidoreductase
LPA65_RS07715	COG1349	DNA-binding transcription factor activity
LPA65_RS07725	COG1393	Belongs to the ArsC family
LPA65_RS07745	COG0546	phosphoglycolate phosphatase activity
LPA65_RS07775	COG0583	DNA-binding transcription factor activity
LPA65_RS07780	COG0604	alcohol dehydrogenase
LPA65_RS07790	COG0446	pyridine nucleotide-disulphide oxidoreductase
LPA65_RS07795	COG2197	response regulator
LPA65_RS07800	COG4585	Histidine kinase
LPA65_RS07810	COG1131	(ABC) transporter
LPA65_RS07820	COG0519	Catalyzes the synthesis of GMP from XMP
LPA65_RS07835	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS07840	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LPA65_RS07845	COG0358	DNA primase activity
LPA65_RS07850	COG0751	glycine-tRNA ligase activity
LPA65_RS07855	COG0752	glycyl-tRNA synthetase alpha subunit
LPA65_RS07860	COG1381	Involved in DNA repair and RecF pathway recombination
LPA65_RS07865	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LPA65_RS07870	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LPA65_RS07875	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LPA65_RS07880	COG1702	phosphate starvation-inducible protein PhoH
LPA65_RS07885	COG1610	YqeY-like protein
LPA65_RS07890	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LPA65_RS07895	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LPA65_RS07900	COG1028	Short-chain dehydrogenase reductase Sdr
LPA65_RS07905	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LPA65_RS07915	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LPA65_RS07925	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LPA65_RS07930	COG0124	histidyl-tRNA synthetase
LPA65_RS07935	COG0860	N-Acetylmuramoyl-L-alanine amidase
LPA65_RS07935	COG3103	Sh3 type 3 domain protein
LPA65_RS07935	COG4991	sh3 domain protein
LPA65_RS07940	COG3001	Fructosamine kinase
LPA65_RS07945	COG0546	phosphoglycolate phosphatase activity
LPA65_RS07950	COG1490	D-aminoacyl-tRNA deacylase activity
LPA65_RS07955	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LPA65_RS07965	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LPA65_RS07970	COG2264	protein methyltransferase activity
LPA65_RS07975	COG2094	Belongs to the DNA glycosylase MPG family
LPA65_RS07990	COG0481	GTPase activity
LPA65_RS07995	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
LPA65_RS08000	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LPA65_RS08005	COG1696	Membrane protein involved in D-alanine export
LPA65_RS08010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LPA65_RS08020	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LPA65_RS08025	COG0484	heat shock protein binding
LPA65_RS08030	COG0443	Heat shock 70 kDa protein
LPA65_RS08035	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LPA65_RS08040	COG1420	regulation of RNA biosynthetic process
LPA65_RS08045	COG3527	Alpha-acetolactate decarboxylase
LPA65_RS08050	COG0196	riboflavin kinase activity
LPA65_RS08055	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LPA65_RS08060	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LPA65_RS08065	COG0287	Prephenate dehydrogenase
LPA65_RS08070	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LPA65_RS08080	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LPA65_RS08085	COG0738	Major facilitator superfamily
LPA65_RS08090	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS08095	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LPA65_RS08100	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LPA65_RS08110	COG2740	Nucleic-acid-binding protein implicated in transcription termination
LPA65_RS08115	COG0195	Participates in both transcription termination and antitermination
LPA65_RS08120	COG0779	Required for maturation of 30S ribosomal subunits
LPA65_RS08125	COG2176	DNA-directed DNA polymerase activity
LPA65_RS08130	COG0442	prolyl-tRNA aminoacylation
LPA65_RS08135	COG0750	zinc metalloprotease
LPA65_RS08140	COG4589	Belongs to the CDS family
LPA65_RS08145	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LPA65_RS08150	COG0233	cytoplasmic translational termination
LPA65_RS08155	COG0528	UMP kinase activity
LPA65_RS08160	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LPA65_RS08165	COG0052	Belongs to the universal ribosomal protein uS2 family
LPA65_RS08175	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LPA65_RS08180	COG2827	Endonuclease containing a URI domain
LPA65_RS08185	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LPA65_RS08190	COG0204	Acyl-transferase
LPA65_RS08195	COG3763	UPF0154 protein
LPA65_RS08200	COG4224	UPF0291 protein
LPA65_RS08205	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LPA65_RS08225	COG3425	synthase
LPA65_RS08240	COG0463	Glycosyl transferase, family 2
LPA65_RS08285	COG0393	Putative heavy-metal-binding
LPA65_RS08300	COG2801	Transposase and inactivated derivatives
LPA65_RS08310	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LPA65_RS08315	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LPA65_RS08315	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LPA65_RS08320	COG5416	Lipopolysaccharide assembly protein A domain
LPA65_RS08325	COG0300	oxidoreductase activity
LPA65_RS08330	COG1234	tRNA 3'-trailer cleavage
LPA65_RS08340	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LPA65_RS08345	COG1349	DNA-binding transcription factor activity
LPA65_RS08350	COG1105	Belongs to the carbohydrate kinase PfkB family
LPA65_RS08355	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LPA65_RS08355	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LPA65_RS08355	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LPA65_RS08360	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LPA65_RS08385	COG0438	transferase activity, transferring glycosyl groups
LPA65_RS08390	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LPA65_RS08395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LPA65_RS08400	COG4464	protein tyrosine phosphatase activity
LPA65_RS08405	COG0489	protein tyrosine kinase activity
LPA65_RS08415	COG0322	excinuclease ABC activity
LPA65_RS08420	COG1126	abc transporter atp-binding protein
LPA65_RS08425	COG0765	amino acid transport
LPA65_RS08445	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LPA65_RS08450	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LPA65_RS08455	COG0544	peptidyl-prolyl cis-trans isomerase activity
LPA65_RS08460	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LPA65_RS08485	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LPA65_RS08490	COG0268	Binds directly to 16S ribosomal RNA
LPA65_RS08495	COG1466	dna polymerase III delta subunit
LPA65_RS08500	COG2333	competence protein COMEC
LPA65_RS08500	COG0658	competence protein
LPA65_RS08505	COG2131	deaminase
LPA65_RS08510	COG1596	polysaccharide export
LPA65_RS08510	COG1555	photosystem II stabilization
LPA65_RS08515	COG3480	Lon protease (S16) C-terminal proteolytic domain
LPA65_RS08520	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LPA65_RS08525	COG0742	ribosomal rna small subunit methyltransferase
LPA65_RS08530	COG4471	UPF0298 protein
LPA65_RS08535	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
LPA65_RS08540	COG0772	Belongs to the SEDS family
LPA65_RS08565	COG1217	gtp-binding protein TYPA
LPA65_RS08570	COG0483	inositol monophosphate 1-phosphatase activity
LPA65_RS08575	COG4476	Belongs to the UPF0223 family
LPA65_RS08580	COG0039	L-malate dehydrogenase activity
LPA65_RS08605	COG0242	peptide deformylase activity
LPA65_RS08615	COG5503	Protein of unknown function (DUF1447)
LPA65_RS08620	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LPA65_RS08625	COG1597	lipid kinase activity
LPA65_RS08640	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LPA65_RS08645	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LPA65_RS08680	COG0569	domain protein
LPA65_RS08685	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LPA65_RS08690	COG0482	sulfurtransferase activity
LPA65_RS08700	COG1104	cysteine desulfurase activity
LPA65_RS08705	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LPA65_RS08715	COG0494	nUDIX hydrolase
LPA65_RS08720	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LPA65_RS08725	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LPA65_RS08730	COG3599	regulation of cell shape
LPA65_RS08740	COG0762	integral membrane protein
LPA65_RS08745	COG1799	cell septum assembly
LPA65_RS08760	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LPA65_RS08765	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LPA65_RS08770	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LPA65_RS08775	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LPA65_RS08780	COG0768	penicillin binding
LPA65_RS08790	COG0275	rRNA processing
LPA65_RS08795	COG2001	Belongs to the MraZ family
LPA65_RS08815	COG1674	ftsk spoiiie
LPA65_RS08820	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LPA65_RS08830	COG1114	Component of the transport system for branched-chain amino acids
LPA65_RS08840	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LPA65_RS08845	COG0628	permease
LPA65_RS08855	COG2706	6-phosphogluconolactonase activity
LPA65_RS08860	COG3142	Participates in the control of copper homeostasis
LPA65_RS08865	COG0564	pseudouridine synthase activity
LPA65_RS08870	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LPA65_RS08875	COG2357	RelA SpoT domain protein
LPA65_RS08885	COG2801	Transposase and inactivated derivatives
LPA65_RS08895	COG1164	Oligoendopeptidase f
LPA65_RS08905	COG4862	establishment of competence for transformation
LPA65_RS08910	COG1393	Belongs to the ArsC family
LPA65_RS08915	COG1234	tRNA 3'-trailer cleavage
LPA65_RS09055	COG1098	S1 RNA binding domain
LPA65_RS09065	COG0586	Pfam SNARE associated Golgi protein
LPA65_RS09075	COG0647	UMP catabolic process
LPA65_RS09080	COG4470	Protein conserved in bacteria
LPA65_RS09085	COG0737	Belongs to the 5'-nucleotidase family
LPA65_RS09095	COG1113	amino acid transport
LPA65_RS09100	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LPA65_RS09105	COG0827	DNA restriction-modification system
LPA65_RS09135	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LPA65_RS09145	COG0217	transcriptional regulatory protein
LPA65_RS09160	COG1609	Transcriptional regulator
LPA65_RS09165	COG0006	proline dipeptidase activity
LPA65_RS09170	COG0789	Transcriptional regulator
LPA65_RS09185	COG0668	transmembrane transport
LPA65_RS09190	COG1473	amidohydrolase
LPA65_RS09195	COG2171	N-acyltransferase activity
LPA65_RS09200	COG0517	IMP dehydrogenase activity
LPA65_RS09210	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LPA65_RS09215	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LPA65_RS09225	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS09230	COG3118	belongs to the thioredoxin family
LPA65_RS09235	COG1193	negative regulation of DNA recombination
LPA65_RS09245	COG3906	Belongs to the UPF0473 family
LPA65_RS09250	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LPA65_RS09255	COG4472	Bacterial protein of unknown function (DUF965)
LPA65_RS09260	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LPA65_RS09265	COG0513	Belongs to the DEAD box helicase family
LPA65_RS09270	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LPA65_RS09275	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LPA65_RS09280	COG1862	Preprotein translocase
LPA65_RS09285	COG0343	queuine tRNA-ribosyltransferase activity
LPA65_RS09290	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LPA65_RS09295	COG2255	four-way junction helicase activity
LPA65_RS09300	COG0632	four-way junction helicase activity
LPA65_RS09310	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LPA65_RS09320	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LPA65_RS09325	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LPA65_RS09330	COG1692	metallophosphoesterase
LPA65_RS09335	COG1418	mRNA catabolic process
LPA65_RS09340	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LPA65_RS09345	COG1058	Belongs to the CinA family
LPA65_RS09345	COG1546	Belongs to the CinA family
LPA65_RS09350	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LPA65_RS09355	COG1426	Protein conserved in bacteria
LPA65_RS09360	COG0612	Peptidase, M16
LPA65_RS09365	COG0612	Peptidase, M16
LPA65_RS09370	COG0527	aspartate kinase activity
LPA65_RS09380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LPA65_RS09385	COG1126	abc transporter atp-binding protein
LPA65_RS09390	COG0765	amino acid transport
LPA65_RS09395	COG2894	cell division
LPA65_RS09400	COG0850	regulation of cytokinetic process
LPA65_RS09410	COG1792	Involved in formation and maintenance of cell shape
LPA65_RS09415	COG1077	Cell shape determining protein MreB Mrl
LPA65_RS09420	COG2003	Belongs to the UPF0758 family
LPA65_RS09425	COG0285	dihydrofolate synthase activity
LPA65_RS09430	COG0525	valine-tRNA ligase activity
LPA65_RS09440	COG1181	Belongs to the D-alanine--D-alanine ligase family
LPA65_RS09440	COG2918	glutathione biosynthetic process
LPA65_RS09445	COG0301	tRNA thio-modification
LPA65_RS09450	COG1104	cysteine desulfurase activity
LPA65_RS09460	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
LPA65_RS09465	COG1956	GAF domain-containing protein
LPA65_RS09470	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LPA65_RS09475	COG4493	Belongs to the UPF0637 family
LPA65_RS09490	COG0640	Transcriptional regulator
LPA65_RS09495	COG2918	glutathione biosynthetic process
LPA65_RS09495	COG0189	ligase activity
LPA65_RS09500	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LPA65_RS09510	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS09520	COG0589	response to stress
LPA65_RS09540	COG1181	Belongs to the D-alanine--D-alanine ligase family
LPA65_RS09545	COG0604	alcohol dehydrogenase
LPA65_RS09560	COG1464	Belongs to the NlpA lipoprotein family
LPA65_RS09565	COG2011	ABC-type metal ion transport system permease component
LPA65_RS09570	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LPA65_RS09575	COG0509	glycine decarboxylation via glycine cleavage system
LPA65_RS09580	COG0772	Belongs to the SEDS family
LPA65_RS09590	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LPA65_RS09595	COG1077	Cell shape determining protein MreB Mrl
LPA65_RS09600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LPA65_RS09605	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LPA65_RS09610	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LPA65_RS09615	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LPA65_RS09620	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LPA65_RS09625	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LPA65_RS09630	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LPA65_RS09635	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LPA65_RS09640	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LPA65_RS09645	COG0356	it plays a direct role in the translocation of protons across the membrane
LPA65_RS09650	COG2233	PERMEase
LPA65_RS09670	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LPA65_RS09675	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LPA65_RS09680	COG0009	L-threonylcarbamoyladenylate synthase
LPA65_RS09685	COG2890	protein-(glutamine-N5) methyltransferase activity
LPA65_RS09690	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LPA65_RS09695	COG1435	thymidine kinase activity
LPA65_RS09700	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LPA65_RS09705	COG3442	glutamine amidotransferase
LPA65_RS09710	COG1482	cell wall glycoprotein biosynthetic process
LPA65_RS09715	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LPA65_RS09725	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LPA65_RS09740	COG1132	(ABC) transporter
LPA65_RS09755	COG0726	polysaccharide deacetylase
LPA65_RS09760	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS09780	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS10010	COG1396	sequence-specific DNA binding
LPA65_RS10050	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
LPA65_RS10075	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS10095	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS10200	COG1783	phage Terminase large subunit
LPA65_RS10325	COG1396	sequence-specific DNA binding
LPA65_RS10365	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
LPA65_RS10390	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS10410	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS10515	COG1783	phage Terminase large subunit
LPA65_RS10640	COG1396	sequence-specific DNA binding
LPA65_RS10680	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
LPA65_RS10745	COG4695	Portal protein
LPA65_RS10815	COG4974	Belongs to the 'phage' integrase family
LPA65_RS10890	COG1132	(ABC) transporter
LPA65_RS10895	COG0438	transferase activity, transferring glycosyl groups
LPA65_RS10900	COG0577	efflux transmembrane transporter activity
LPA65_RS10900	COG1136	(ABC) transporter
LPA65_RS10910	COG0166	Belongs to the GPI family
LPA65_RS10915	COG4975	Glucose uptake
LPA65_RS10920	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LPA65_RS10925	COG3850	Histidine kinase
LPA65_RS10925	COG5002	protein histidine kinase activity
LPA65_RS10930	COG0745	RESPONSE REGULATOR receiver
LPA65_RS10935	COG2848	UPF0210 protein
LPA65_RS10940	COG3830	Belongs to the UPF0237 family
LPA65_RS10955	COG2801	Transposase and inactivated derivatives
LPA65_RS10975	COG0477	Major facilitator Superfamily
LPA65_RS10995	COG0791	NLP P60 protein
LPA65_RS11000	COG1522	sequence-specific DNA binding
LPA65_RS11020	COG0488	(ABC) transporter
LPA65_RS11050	COG2190	(PTS) system
LPA65_RS11050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LPA65_RS11050	COG1263	PTS System
LPA65_RS11055	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LPA65_RS11060	COG1307	EDD domain protein, DegV family
LPA65_RS11075	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
LPA65_RS11095	COG4120	Belongs to the binding-protein-dependent transport system permease family
LPA65_RS11105	COG0446	pyridine nucleotide-disulphide oxidoreductase
LPA65_RS11115	COG2084	Dehydrogenase
LPA65_RS11120	COG0861	Integral membrane protein TerC family
LPA65_RS11125	COG0110	maltose O-acetyltransferase activity
LPA65_RS11130	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LPA65_RS11135	COG0140	phosphoribosyl-ATP diphosphatase activity
LPA65_RS11140	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LPA65_RS11145	COG0107	imidazoleglycerol-phosphate synthase activity
LPA65_RS11150	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LPA65_RS11155	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LPA65_RS11160	COG0131	Imidazoleglycerol-phosphate dehydratase
LPA65_RS11165	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LPA65_RS11170	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LPA65_RS11175	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
LPA65_RS11180	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LPA65_RS11200	COG0789	Transcriptional regulator
LPA65_RS11205	COG0300	oxidoreductase activity
LPA65_RS11215	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LPA65_RS11230	COG3548	integral membrane protein
LPA65_RS11250	COG1368	sulfuric ester hydrolase activity
LPA65_RS11255	COG0584	glycerophosphoryl diester phosphodiesterase
LPA65_RS11265	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS11270	COG0492	ferredoxin-NADP+ reductase activity
LPA65_RS11285	COG2326	polyphosphate kinase activity
LPA65_RS11290	COG0778	Nitroreductase
LPA65_RS11300	COG0328	RNA-DNA hybrid ribonuclease activity
LPA65_RS11310	COG1609	Transcriptional regulator
LPA65_RS11320	COG0673	inositol 2-dehydrogenase activity
LPA65_RS11325	COG0673	inositol 2-dehydrogenase activity
LPA65_RS11330	COG0025	NhaP-type Na H and K H
LPA65_RS11335	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LPA65_RS11340	COG1335	isochorismatase
LPA65_RS11350	COG1131	(ABC) transporter
LPA65_RS11355	COG1725	Transcriptional regulator
LPA65_RS11420	COG0028	Belongs to the TPP enzyme family
LPA65_RS11430	COG1073	alpha beta
LPA65_RS11435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LPA65_RS11440	COG0626	cystathionine gamma-synthase activity
LPA65_RS11455	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS11475	COG0095	Lipoate-protein ligase
LPA65_RS11480	COG1705	Flagellar rod assembly protein muramidase FlgJ
LPA65_RS11485	COG0589	response to stress
LPA65_RS11490	COG0564	pseudouridine synthase activity
LPA65_RS11495	COG1396	sequence-specific DNA binding
LPA65_RS11510	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
LPA65_RS11520	COG2188	Transcriptional regulator
LPA65_RS11525	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LPA65_RS11535	COG1418	mRNA catabolic process
LPA65_RS11565	COG1253	flavin adenine dinucleotide binding
LPA65_RS11570	COG1780	Probably involved in ribonucleotide reductase function
LPA65_RS11580	COG2814	Major facilitator Superfamily
LPA65_RS11585	COG0789	Transcriptional regulator
LPA65_RS11590	COG0604	alcohol dehydrogenase
LPA65_RS11600	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LPA65_RS11610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LPA65_RS11615	COG0436	Aminotransferase
LPA65_RS11620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LPA65_RS11635	COG0583	DNA-binding transcription factor activity
LPA65_RS11640	COG0702	epimerase
LPA65_RS11650	COG1074	ATP-dependent DNA helicase activity
LPA65_RS11655	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
LPA65_RS11665	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LPA65_RS11670	COG0284	orotidine-5'-phosphate decarboxylase activity
LPA65_RS11675	COG0167	dihydroorotate dehydrogenase activity
LPA65_RS11680	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LPA65_RS11685	COG0505	Belongs to the CarA family
LPA65_RS11690	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LPA65_RS11695	COG0540	Belongs to the ATCase OTCase family
LPA65_RS11700	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LPA65_RS11705	COG2508	Transcriptional regulator
LPA65_RS11710	COG2233	PERMEase
LPA65_RS11715	COG2252	PERMEase
LPA65_RS11735	COG1215	transferase activity, transferring glycosyl groups
LPA65_RS11745	COG0151	Belongs to the GarS family
LPA65_RS11750	COG0138	bifunctional purine biosynthesis protein purh
LPA65_RS11755	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LPA65_RS11760	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LPA65_RS11770	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LPA65_RS11775	COG0047	phosphoribosylformylglycinamidine synthase activity
LPA65_RS11780	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LPA65_RS11785	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LPA65_RS11790	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LPA65_RS11800	COG3976	FMN-binding domain protein
LPA65_RS11800	COG1053	succinate dehydrogenase
LPA65_RS11800	COG0431	NADPH-dependent FMN reductase
LPA65_RS11805	COG0431	NADPH-dependent FMN reductase
LPA65_RS11805	COG3976	FMN-binding domain protein
LPA65_RS11805	COG1053	succinate dehydrogenase
LPA65_RS11810	COG0095	Lipoate-protein ligase
LPA65_RS11815	COG2365	Tyrosine phosphatase family
LPA65_RS11820	COG3338	carbonate dehydratase activity
LPA65_RS11835	COG1136	(ABC) transporter
LPA65_RS11850	COG1725	Transcriptional regulator
LPA65_RS11855	COG1131	(ABC) transporter
LPA65_RS11865	COG0589	response to stress
LPA65_RS11875	COG2246	polysaccharide biosynthetic process
LPA65_RS11895	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LPA65_RS11915	COG0366	Alpha amylase catalytic
LPA65_RS11925	COG0561	phosphatase activity
LPA65_RS11935	COG0110	maltose O-acetyltransferase activity
LPA65_RS11940	COG0494	nUDIX hydrolase
LPA65_RS11975	COG1827	regulation of RNA biosynthetic process
LPA65_RS11980	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LPA65_RS11985	COG1309	transcriptional regulator
LPA65_RS11995	COG1131	(ABC) transporter
LPA65_RS12000	COG3048	D-serine ammonia-lyase activity
LPA65_RS12005	COG2723	6-phospho-beta-galactosidase activity
LPA65_RS12010	COG2723	6-phospho-beta-galactosidase activity
LPA65_RS12015	COG1447	Phosphotransferase system cellobiose-specific component IIA
LPA65_RS12020	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LPA65_RS12025	COG2188	Transcriptional regulator
LPA65_RS12030	COG1216	Glycosyl transferase, family 2
LPA65_RS12045	COG0561	phosphatase activity
LPA65_RS12050	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LPA65_RS12075	COG0716	FMN binding
LPA65_RS12100	COG0710	3-dehydroquinate dehydratase activity
LPA65_RS12105	COG0531	amino acid
LPA65_RS12125	COG0583	DNA-binding transcription factor activity
LPA65_RS12150	COG4720	Psort location CytoplasmicMembrane, score
LPA65_RS12155	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LPA65_RS12170	COG4990	cell redox homeostasis
LPA65_RS12190	COG1811	Na channel or pump
LPA65_RS12195	COG4978	Transcriptional regulator
LPA65_RS12195	COG0789	Transcriptional regulator
LPA65_RS12210	COG0577	efflux transmembrane transporter activity
LPA65_RS12215	COG1136	(ABC) transporter
LPA65_RS12255	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS12260	COG2814	Major facilitator Superfamily
LPA65_RS12270	COG2814	Major facilitator Superfamily
LPA65_RS12280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LPA65_RS12285	COG2855	membrane
LPA65_RS12290	COG0583	DNA-binding transcription factor activity
LPA65_RS12315	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LPA65_RS12325	COG4152	abc transporter atp-binding protein
LPA65_RS12335	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS12340	COG4221	oxidoreductase activity
LPA65_RS12355	COG0789	Transcriptional regulator
LPA65_RS12375	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LPA65_RS12400	COG0456	acetyltransferase
LPA65_RS12425	COG0583	DNA-binding transcription factor activity
LPA65_RS12435	COG1063	alcohol dehydrogenase
LPA65_RS12440	COG1028	Short-chain dehydrogenase reductase Sdr
LPA65_RS12450	COG0589	response to stress
LPA65_RS12455	COG0110	maltose O-acetyltransferase activity
LPA65_RS12460	COG1011	Hydrolase
LPA65_RS12475	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LPA65_RS12485	COG0667	Aldo Keto reductase
LPA65_RS12490	COG1132	(ABC) transporter
LPA65_RS12495	COG1132	(ABC) transporter
LPA65_RS12500	COG2814	Major facilitator Superfamily
LPA65_RS12505	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS12515	COG1511	domain protein
LPA65_RS12515	COG1511	domain protein
LPA65_RS12525	COG0640	Transcriptional regulator
LPA65_RS12560	COG0488	(ABC) transporter
LPA65_RS12565	COG0561	phosphatase activity
LPA65_RS12575	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LPA65_RS12585	COG2801	Transposase and inactivated derivatives
LPA65_RS12600	COG2270	Major facilitator Superfamily
LPA65_RS12650	COG1328	CTP reductase activity
LPA65_RS12660	COG0242	peptide deformylase activity
LPA65_RS12670	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LPA65_RS12690	COG0583	DNA-binding transcription factor activity
LPA65_RS12700	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS12705	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LPA65_RS12755	COG4932	domain protein
LPA65_RS12760	COG0697	spore germination
LPA65_RS12790	COG1132	(ABC) transporter
LPA65_RS12800	COG1609	Transcriptional regulator
LPA65_RS12805	COG0561	phosphatase activity
LPA65_RS12810	COG0778	Nitroreductase
LPA65_RS12815	COG1263	PTS System
LPA65_RS12815	COG2190	(PTS) system
LPA65_RS12815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LPA65_RS12820	COG1116	anion transmembrane transporter activity
LPA65_RS12825	COG4120	Belongs to the binding-protein-dependent transport system permease family
LPA65_RS12860	COG0410	ABC transporter
LPA65_RS12875	COG0559	Belongs to the binding-protein-dependent transport system permease family
LPA65_RS12890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LPA65_RS12890	COG5549	protein import
LPA65_RS12895	COG2246	polysaccharide biosynthetic process
LPA65_RS12905	COG1914	H( )-stimulated, divalent metal cation uptake system
LPA65_RS12925	COG0640	Transcriptional regulator
LPA65_RS12940	COG1136	(ABC) transporter
LPA65_RS12940	COG0577	efflux transmembrane transporter activity
LPA65_RS12975	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LPA65_RS12980	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LPA65_RS12985	COG2723	6-phospho-beta-galactosidase activity
LPA65_RS12995	COG0789	Transcriptional regulator
LPA65_RS13000	COG0741	lytic transglycosylase activity
LPA65_RS13020	COG0803	Belongs to the bacterial solute-binding protein 9 family
LPA65_RS13045	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LPA65_RS13055	COG1132	(ABC) transporter
LPA65_RS13060	COG1132	(ABC) transporter
LPA65_RS13070	COG1473	amidohydrolase
LPA65_RS13075	COG1028	Short-chain dehydrogenase reductase Sdr
LPA65_RS13090	COG0531	amino acid
LPA65_RS13125	COG2217	Heavy metal translocating P-type atpase
LPA65_RS13220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LPA65_RS13235	COG1733	regulation of RNA biosynthetic process
LPA65_RS13240	COG2814	Major facilitator Superfamily
LPA65_RS13250	COG0367	asparagine synthase
LPA65_RS13255	COG3279	Response regulator of the LytR AlgR family
LPA65_RS13270	COG1309	transcriptional regulator
LPA65_RS13280	COG1012	belongs to the aldehyde dehydrogenase family
LPA65_RS13295	COG1733	regulation of RNA biosynthetic process
LPA65_RS13300	COG0300	oxidoreductase activity
LPA65_RS13320	COG0667	Aldo Keto reductase
LPA65_RS13335	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
LPA65_RS13340	COG1120	ATPase activity
LPA65_RS13345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LPA65_RS13350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LPA65_RS13355	COG4221	oxidoreductase activity
LPA65_RS13360	COG0110	maltose O-acetyltransferase activity
LPA65_RS13365	COG1028	Short-chain dehydrogenase reductase Sdr
LPA65_RS13405	COG0481	GTPase activity
LPA65_RS13415	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LPA65_RS13425	COG2816	NAD+ diphosphatase activity
LPA65_RS13435	COG3976	FMN-binding domain protein
LPA65_RS13435	COG0431	NADPH-dependent FMN reductase
LPA65_RS13435	COG1053	succinate dehydrogenase
LPA65_RS13445	COG0783	Belongs to the Dps family
LPA65_RS13455	COG3976	FMN-binding domain protein
LPA65_RS13455	COG1053	succinate dehydrogenase
LPA65_RS13455	COG0431	NADPH-dependent FMN reductase
LPA65_RS13460	COG0583	DNA-binding transcription factor activity
LPA65_RS13470	COG0789	Transcriptional regulator
LPA65_RS13490	COG0693	protein deglycase activity
LPA65_RS13515	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
LPA65_RS13525	COG1204	response to ionizing radiation
LPA65_RS13530	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS13565	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS13580	COG0745	RESPONSE REGULATOR receiver
LPA65_RS13585	COG2205	protein histidine kinase activity
LPA65_RS13610	COG2226	methyltransferase
LPA65_RS13620	COG0588	phosphoglycerate mutase activity
LPA65_RS13625	COG0628	permease
LPA65_RS13640	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LPA65_RS13650	COG2815	serine threonine protein kinase
LPA65_RS13650	COG0515	serine threonine protein kinase
LPA65_RS13690	COG1247	-acetyltransferase
LPA65_RS13695	COG1686	Belongs to the peptidase S11 family
LPA65_RS13720	COG0517	IMP dehydrogenase activity
LPA65_RS13720	COG0516	GMP reductase activity
LPA65_RS13730	COG0012	GTP binding
LPA65_RS13735	COG4481	Protein conserved in bacteria
LPA65_RS13740	COG1475	DNA binding
LPA65_RS13745	COG1192	Involved in chromosome partitioning
LPA65_RS13755	COG0357	Ribosomal RNA small subunit methyltransferase G
LPA65_RS13760	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LPA65_RS13770	COG0583	DNA-binding transcription factor activity
LPA65_RS13775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LPA65_RS13780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LPA65_RS13785	COG0765	amino acid transport
LPA65_RS13790	COG1126	abc transporter atp-binding protein
LPA65_RS13795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LPA65_RS13800	COG2801	Transposase and inactivated derivatives
LPA65_RS13810	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS13835	COG1373	ATPase (AAA superfamily
LPA65_RS13845	COG0390	transport system, permease component
LPA65_RS13850	COG4619	ABC transporter
LPA65_RS13855	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LPA65_RS13870	COG0561	phosphatase activity
LPA65_RS13920	COG0735	belongs to the Fur family
LPA65_RS13945	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS13950	COG1380	Effector of murein hydrolase LrgA
LPA65_RS13960	COG1307	EDD domain protein, DegV family
LPA65_RS13970	COG2738	Putative neutral zinc metallopeptidase
LPA65_RS13975	COG1233	COG1233 Phytoene dehydrogenase and related
LPA65_RS13980	COG1562	ergosterol biosynthetic process
LPA65_RS13995	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LPA65_RS14000	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LPA65_RS14005	COG2188	Transcriptional regulator
LPA65_RS14020	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS14025	COG1929	Belongs to the glycerate kinase type-1 family
LPA65_RS14040	COG1131	(ABC) transporter
LPA65_RS14050	COG2801	Transposase and inactivated derivatives
LPA65_RS14080	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LPA65_RS14085	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LPA65_RS14090	COG0516	GMP reductase activity
LPA65_RS14095	COG2365	Tyrosine phosphatase family
LPA65_RS14100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LPA65_RS14110	COG0531	amino acid
LPA65_RS14115	COG3158	transport of potassium into the cell
LPA65_RS14125	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS14130	COG0628	permease
LPA65_RS14135	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LPA65_RS14150	COG1272	protein, Hemolysin III
LPA65_RS14155	COG0640	Transcriptional regulator
LPA65_RS14190	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LPA65_RS14200	COG0302	gtp cyclohydrolase
LPA65_RS14205	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LPA65_RS14225	COG0803	Belongs to the bacterial solute-binding protein 9 family
LPA65_RS14230	COG2814	Major facilitator Superfamily
LPA65_RS14265	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LPA65_RS14270	COG1882	Formate acetyltransferase
LPA65_RS14275	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LPA65_RS14285	COG2151	metal-sulfur cluster biosynthetic enzyme
LPA65_RS14290	COG4989	oxidoreductase activity
LPA65_RS14330	COG2217	Heavy metal translocating P-type atpase
LPA65_RS14340	COG2315	Protein conserved in bacteria
LPA65_RS14350	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
LPA65_RS14355	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LPA65_RS14365	COG1757	Na H antiporter
LPA65_RS14370	COG1113	amino acid transport
LPA65_RS14380	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LPA65_RS14395	COG1393	Belongs to the ArsC family
LPA65_RS14400	COG3189	MarR family transcriptional regulator
LPA65_RS14410	COG1194	a g-specific adenine glycosylase
LPA65_RS14425	COG0071	Belongs to the small heat shock protein (HSP20) family
LPA65_RS14445	COG0697	spore germination
LPA65_RS14460	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
LPA65_RS14485	COG0477	Major facilitator Superfamily
LPA65_RS14545	COG0737	Belongs to the 5'-nucleotidase family
LPA65_RS14555	COG0656	L-ascorbic acid biosynthetic process
LPA65_RS14575	COG1968	undecaprenyl-diphosphatase activity
LPA65_RS14580	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
LPA65_RS14620	COG0076	glutamate decarboxylase activity
LPA65_RS14625	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS14665	COG2226	methyltransferase
LPA65_RS14690	COG2217	Heavy metal translocating P-type atpase
LPA65_RS14695	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LPA65_RS14700	COG3118	belongs to the thioredoxin family
LPA65_RS14705	COG1937	Protein conserved in bacteria
LPA65_RS14725	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LPA65_RS14730	COG3590	peptidase
LPA65_RS14750	COG0446	pyridine nucleotide-disulphide oxidoreductase
LPA65_RS14780	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS14805	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LPA65_RS14815	COG1114	Component of the transport system for branched-chain amino acids
LPA65_RS14825	COG1874	Beta-galactosidase
LPA65_RS14830	COG1609	Transcriptional regulator
LPA65_RS14835	COG2184	nucleotidyltransferase activity
LPA65_RS14840	COG2944	sequence-specific DNA binding
LPA65_RS14845	COG1609	Transcriptional regulator
LPA65_RS14850	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
LPA65_RS14855	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LPA65_RS14860	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LPA65_RS14880	COG2211	Major facilitator Superfamily
LPA65_RS14880	COG2190	(PTS) system
LPA65_RS14885	COG2017	converts alpha-aldose to the beta-anomer
LPA65_RS14890	COG1609	Transcriptional regulator
LPA65_RS14895	COG0667	Aldo Keto reductase
LPA65_RS14915	COG0710	3-dehydroquinate dehydratase activity
LPA65_RS14920	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LPA65_RS14925	COG0583	DNA-binding transcription factor activity
LPA65_RS14930	COG2271	Major facilitator Superfamily
LPA65_RS14945	COG1028	Short-chain dehydrogenase reductase Sdr
LPA65_RS14960	COG2271	Major facilitator Superfamily
LPA65_RS14970	COG2267	carboxylic ester hydrolase activity
LPA65_RS14975	COG2188	Transcriptional regulator
LPA65_RS14980	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LPA65_RS14985	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LPA65_RS14990	COG2971	BadF BadG BcrA BcrD
LPA65_RS15005	COG2972	Histidine kinase
LPA65_RS15010	COG3976	FMN-binding domain protein
LPA65_RS15010	COG1053	succinate dehydrogenase
LPA65_RS15015	COG1929	Belongs to the glycerate kinase type-1 family
LPA65_RS15020	COG0383	alpha-mannosidase activity
LPA65_RS15025	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LPA65_RS15025	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LPA65_RS15025	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LPA65_RS15035	COG2723	6-phospho-beta-galactosidase activity
LPA65_RS15045	COG3711	transcriptional antiterminator
LPA65_RS15050	COG2723	6-phospho-beta-galactosidase activity
LPA65_RS15055	COG2723	6-phospho-beta-galactosidase activity
LPA65_RS15060	COG2190	(PTS) system
LPA65_RS15060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LPA65_RS15060	COG1263	PTS System
LPA65_RS15080	COG2211	Major facilitator Superfamily
LPA65_RS15095	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
LPA65_RS15110	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LPA65_RS15120	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS15135	COG3711	transcriptional antiterminator
LPA65_RS15140	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS15155	COG3775	system Galactitol-specific IIC component
LPA65_RS15160	COG3414	Phosphotransferase system galactitol-specific IIB component
LPA65_RS15170	COG1349	DNA-binding transcription factor activity
LPA65_RS15175	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
LPA65_RS15180	COG1737	Transcriptional regulator
LPA65_RS15200	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LPA65_RS15220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LPA65_RS15225	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
LPA65_RS15245	COG3732	PTS system glucitol sorbitol-specific
LPA65_RS15250	COG3730	PTS system glucitol sorbitol-specific
LPA65_RS15270	COG4975	Glucose uptake
LPA65_RS15275	COG1869	D-ribose catabolic process
LPA65_RS15285	COG1609	Transcriptional regulator
LPA65_RS15290	COG1454	alcohol dehydrogenase
LPA65_RS15290	COG1012	belongs to the aldehyde dehydrogenase family
LPA65_RS15300	COG1695	Transcriptional regulator
LPA65_RS15305	COG3479	Phenolic acid decarboxylase
LPA65_RS15320	COG1307	EDD domain protein, DegV family
LPA65_RS15345	COG0445	tRNA wobble uridine modification
LPA65_RS15350	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LPA65_RS15355	COG1847	R3H domain protein
LPA65_RS15365	COG4166	transmembrane transport
LPA65_RS15370	COG0706	membrane insertase activity
LPA65_RS15375	COG0594	ribonuclease P activity
LPA65_RS15380	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LPA65_RS15385	COG1192	Involved in chromosome partitioning
LPA65_RS15430	COG1346	cytolysis
LPA65_RS15440	COG3279	Response regulator of the LytR AlgR family
LPA65_RS15445	COG3275	phosphorelay sensor kinase activity
LPA65_RS15450	COG1846	Transcriptional regulator
LPA65_RS15560	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LPA65_RS15575	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LPA65_RS15575	COG0551	DNA topoisomerase type I activity
LPA65_RS15685	COG0662	Cupin 2, conserved barrel domain protein
LPA65_RS15720	COG0471	metal ion transport
LPA65_RS15765	COG0028	Belongs to the TPP enzyme family
LPA65_RS15770	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS15775	COG0602	queuosine metabolic process
LPA65_RS15780	COG1328	CTP reductase activity
LPA65_RS15795	COG2801	Transposase and inactivated derivatives
LPA65_RS15810	COG0582	viral genome integration into host DNA
LPA65_RS15815	COG2226	methyltransferase
LPA65_RS15825	COG2814	Major facilitator Superfamily
LPA65_RS15835	COG0367	asparagine synthase
LPA65_RS15855	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LPA65_RS15860	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS15875	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS15885	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LPA65_RS15890	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LPA65_RS15895	COG2801	Transposase and inactivated derivatives
LPA65_RS15945	COG1113	amino acid transport
LPA65_RS15960	COG1113	amino acid transport
LPA65_RS15980	COG1192	Involved in chromosome partitioning
LPA65_RS15985	COG1192	Involved in chromosome partitioning
LPA65_RS15995	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS16000	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LPA65_RS16015	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LPA65_RS16025	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LPA65_RS16060	COG1846	Transcriptional regulator
LPA65_RS16070	COG3158	transport of potassium into the cell
LPA65_RS16085	COG2801	Transposase and inactivated derivatives
LPA65_RS16105	COG1653	transport
LPA65_RS16110	COG3842	ATPase activity
LPA65_RS16135	COG2261	transglycosylase associated protein
LPA65_RS16140	COG2814	Major facilitator Superfamily
LPA65_RS16145	COG5039	Polysaccharide pyruvyl transferase
LPA65_RS16150	COG2814	Major facilitator Superfamily
LPA65_RS16155	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS16160	COG4876	unkown
LPA65_RS16165	COG4716	Myosin-crossreactive antigen
LPA65_RS16185	COG1131	(ABC) transporter
LPA65_RS16255	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LPA65_RS16270	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS16320	COG3475	LICD family
LPA65_RS16330	COG1216	Glycosyl transferase, family 2
LPA65_RS16330	COG1442	glycosyl transferase family 8
LPA65_RS16350	COG2801	Transposase and inactivated derivatives
LPA65_RS16365	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS16385	COG0489	protein tyrosine kinase activity
LPA65_RS16390	COG4464	protein tyrosine phosphatase activity
LPA65_RS16400	COG2244	polysaccharide biosynthetic process
LPA65_RS16405	COG3328	transposase activity
LPA65_RS16410	COG0562	UDP-galactopyranose mutase
LPA65_RS16425	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LPA65_RS16450	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LPA65_RS16465	COG1192	Involved in chromosome partitioning
LPA65_RS16505	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS16520	COG1473	amidohydrolase
LPA65_RS16535	COG0477	Major facilitator Superfamily
LPA65_RS16565	COG2826	transposase and inactivated derivatives, IS30 family
LPA65_RS16620	COG1192	Involved in chromosome partitioning
LPA65_RS16845	COG0366	Alpha amylase catalytic
LPA65_RS16845	COG5263	repeat protein