locus-tag	class	description
SH83_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SH83_RS00010	COG0592	DNA-directed DNA polymerase activity
SH83_RS00015	COG2501	S4 domain
SH83_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SH83_RS00025	COG0187	DNA topoisomerase II activity
SH83_RS00035	COG0360	Binds together with S18 to 16S ribosomal RNA
SH83_RS00040	COG0629	single-stranded DNA binding
SH83_RS00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SH83_RS00055	COG0359	binds to the 23S rRNA
SH83_RS00060	COG0305	Participates in initiation and elongation during chromosome replication
SH83_RS00065	COG2814	Major facilitator Superfamily
SH83_RS00070	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SH83_RS00075	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SH83_RS00080	COG4166	transmembrane transport
SH83_RS00090	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SH83_RS00095	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SH83_RS00100	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SH83_RS00105	COG0297	glycogen (starch) synthase activity
SH83_RS00110	COG0058	SHG alpha-glucan phosphorylase activity
SH83_RS00115	COG0366	Alpha amylase catalytic
SH83_RS00115	COG3103	Sh3 type 3 domain protein
SH83_RS00125	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SH83_RS00130	COG1554	hydrolase, family 65, central catalytic
SH83_RS00140	COG1278	Cold shock
SH83_RS00155	COG0745	RESPONSE REGULATOR receiver
SH83_RS00160	COG5002	protein histidine kinase activity
SH83_RS00170	COG4853	Protein conserved in bacteria
SH83_RS00175	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SH83_RS00180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SH83_RS00185	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SH83_RS00220	COG1573	uracil-dna glycosylase
SH83_RS00240	COG1053	succinate dehydrogenase
SH83_RS00240	COG3976	FMN-binding domain protein
SH83_RS00240	COG0431	NADPH-dependent FMN reductase
SH83_RS00245	COG0471	metal ion transport
SH83_RS00260	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SH83_RS00265	COG1028	Short-chain dehydrogenase reductase Sdr
SH83_RS00275	COG0778	Nitroreductase
SH83_RS00280	COG2508	Transcriptional regulator
SH83_RS00290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SH83_RS00295	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
SH83_RS00305	COG2365	Tyrosine phosphatase family
SH83_RS00310	COG2368	4-hydroxyphenylacetate
SH83_RS00330	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SH83_RS00365	COG0604	alcohol dehydrogenase
SH83_RS00390	COG2267	carboxylic ester hydrolase activity
SH83_RS00395	COG3022	response to hydroperoxide
SH83_RS00405	COG4166	transmembrane transport
SH83_RS00435	COG1122	ATPase activity
SH83_RS00440	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SH83_RS00445	COG0310	cobalt ion transport
SH83_RS00450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SH83_RS00455	COG3875	lactate racemase activity
SH83_RS00460	COG1691	(AIR) carboxylase
SH83_RS00465	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SH83_RS00470	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SH83_RS00475	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SH83_RS00480	COG1606	tRNA processing
SH83_RS00485	COG0604	alcohol dehydrogenase
SH83_RS00485	COG1028	Short-chain dehydrogenase reductase Sdr
SH83_RS00485	COG3321	synthase
SH83_RS00490	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SH83_RS00495	COG0351	phosphomethylpyrimidine kinase
SH83_RS00500	COG0352	thiamine-phosphate diphosphorylase activity
SH83_RS00510	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SH83_RS00525	COG1113	amino acid transport
SH83_RS00535	COG2267	carboxylic ester hydrolase activity
SH83_RS00540	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SH83_RS00550	COG1983	PspC domain protein
SH83_RS00590	COG2807	transmembrane transport
SH83_RS00595	COG0656	L-ascorbic acid biosynthetic process
SH83_RS00600	COG0667	Aldo Keto reductase
SH83_RS00630	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SH83_RS00635	COG1122	ATPase activity
SH83_RS00640	COG4720	Psort location CytoplasmicMembrane, score
SH83_RS00650	COG2188	Transcriptional regulator
SH83_RS00675	COG1028	Short-chain dehydrogenase reductase Sdr
SH83_RS00695	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SH83_RS00700	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SH83_RS00705	COG1309	transcriptional regulator
SH83_RS00710	COG2376	Dihydroxyacetone kinase
SH83_RS00715	COG2376	Dihydroxyacetone kinase
SH83_RS00720	COG1461	Dihydroxyacetone kinase
SH83_RS00725	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SH83_RS00730	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SH83_RS00735	COG1609	Transcriptional regulator
SH83_RS00740	COG1609	Transcriptional regulator
SH83_RS00745	COG0366	Alpha amylase catalytic
SH83_RS00750	COG2182	Extracellular solute-binding protein
SH83_RS00755	COG1175	transmembrane transport
SH83_RS00760	COG3833	ABC-type maltose transport systems, permease component
SH83_RS00770	COG0366	Alpha amylase catalytic
SH83_RS00775	COG3842	ATPase activity
SH83_RS00830	COG1757	Na H antiporter
SH83_RS00855	COG4166	transmembrane transport
SH83_RS00860	COG4166	transmembrane transport
SH83_RS00870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SH83_RS00875	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SH83_RS00880	COG0406	alpha-ribazole phosphatase activity
SH83_RS00885	COG0667	Aldo Keto reductase
SH83_RS00915	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SH83_RS00920	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SH83_RS00925	COG0488	(ABC) transporter
SH83_RS00935	COG4172	Belongs to the ABC transporter superfamily
SH83_RS00945	COG0386	Belongs to the glutathione peroxidase family
SH83_RS00955	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SH83_RS00970	COG0363	glucosamine-6-phosphate deaminase activity
SH83_RS00980	COG2213	PTS system mannitol-specific
SH83_RS00990	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
SH83_RS00995	COG0246	Mannitol dehydrogenase
SH83_RS01005	COG3118	belongs to the thioredoxin family
SH83_RS01035	COG0431	NADPH-dependent FMN reductase
SH83_RS01040	COG2188	Transcriptional regulator
SH83_RS01060	COG3964	amidohydrolase
SH83_RS01080	COG1045	serine acetyltransferase
SH83_RS01085	COG0626	cystathionine gamma-synthase activity
SH83_RS01090	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SH83_RS01120	COG2188	Transcriptional regulator
SH83_RS01125	COG0366	Alpha amylase catalytic
SH83_RS01130	COG2190	(PTS) system
SH83_RS01130	COG1263	PTS System
SH83_RS01130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SH83_RS01135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SH83_RS01135	COG1263	PTS System
SH83_RS01135	COG2190	(PTS) system
SH83_RS01145	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SH83_RS01150	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SH83_RS01155	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SH83_RS01170	COG0163	prenyltransferase activity
SH83_RS01180	COG1959	2 iron, 2 sulfur cluster binding
SH83_RS01185	COG1309	transcriptional regulator
SH83_RS01190	COG1914	H( )-stimulated, divalent metal cation uptake system
SH83_RS01210	COG2814	Major facilitator Superfamily
SH83_RS01220	COG5002	protein histidine kinase activity
SH83_RS01225	COG0745	RESPONSE REGULATOR receiver
SH83_RS01235	COG1737	Transcriptional regulator
SH83_RS01240	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SH83_RS01255	COG1316	TRANSCRIPTIONal
SH83_RS01260	COG0277	FAD linked oxidase domain protein
SH83_RS01270	COG2357	RelA SpoT domain protein
SH83_RS01280	COG1033	growth of symbiont in host cell
SH83_RS01280	COG2409	Drug exporters of the RND superfamily
SH83_RS01280	COG1033	growth of symbiont in host cell
SH83_RS01280	COG2409	Drug exporters of the RND superfamily
SH83_RS01285	COG2818	Glycosylase
SH83_RS01295	COG0577	efflux transmembrane transporter activity
SH83_RS01300	COG1136	(ABC) transporter
SH83_RS01315	COG0741	lytic transglycosylase activity
SH83_RS01320	COG3942	CHAP domain
SH83_RS01320	COG1388	LysM domain
SH83_RS01350	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SH83_RS01360	COG1846	Transcriptional regulator
SH83_RS01365	COG1252	NADH dehydrogenase
SH83_RS01405	COG3842	ATPase activity
SH83_RS01435	COG1725	Transcriptional regulator
SH83_RS01440	COG1131	(ABC) transporter
SH83_RS01450	COG1012	belongs to the aldehyde dehydrogenase family
SH83_RS01450	COG1454	alcohol dehydrogenase
SH83_RS01485	COG1268	BioY protein
SH83_RS01510	COG2011	ABC-type metal ion transport system permease component
SH83_RS01515	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SH83_RS01520	COG0436	Aminotransferase
SH83_RS01530	COG1682	transport, permease protein
SH83_RS01535	COG1134	teichoic acid transport
SH83_RS01550	COG2814	Major facilitator Superfamily
SH83_RS01555	COG0004	ammonium transporteR
SH83_RS01575	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SH83_RS01585	COG3759	membrane
SH83_RS01590	COG1881	PFAM PEBP family protein
SH83_RS01620	COG0300	oxidoreductase activity
SH83_RS01640	COG1125	glycine betaine transport
SH83_RS01650	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SH83_RS01660	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SH83_RS01760	COG0110	maltose O-acetyltransferase activity
SH83_RS01770	COG0561	phosphatase activity
SH83_RS01780	COG0561	phosphatase activity
SH83_RS01785	COG1114	Component of the transport system for branched-chain amino acids
SH83_RS01830	COG0463	Glycosyl transferase, family 2
SH83_RS01855	COG3279	Response regulator of the LytR AlgR family
SH83_RS01860	COG2801	Transposase and inactivated derivatives
SH83_RS01890	COG2274	protein secretion by the type I secretion system
SH83_RS01930	COG3973	AAA domain
SH83_RS01935	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SH83_RS01940	COG0180	Tryptophanyl-tRNA synthetase
SH83_RS01945	COG2188	Transcriptional regulator
SH83_RS01950	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SH83_RS01965	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SH83_RS01970	COG2723	6-phospho-beta-galactosidase activity
SH83_RS01975	COG1940	carbohydrate kinase activity
SH83_RS01985	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SH83_RS02000	COG0248	Ppx GppA phosphatase
SH83_RS02015	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SH83_RS02020	COG1801	Protein of unknown function DUF72
SH83_RS02030	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SH83_RS02030	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SH83_RS02035	COG2814	Major facilitator Superfamily
SH83_RS02040	COG0084	hydrolase, TatD family'
SH83_RS02045	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SH83_RS02050	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SH83_RS02055	COG4466	Protein conserved in bacteria
SH83_RS02060	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SH83_RS02065	COG1073	alpha beta
SH83_RS02070	COG1121	(ABC) transporter
SH83_RS02075	COG1321	iron dependent repressor
SH83_RS02075	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SH83_RS02080	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SH83_RS02085	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SH83_RS02095	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SH83_RS02115	COG1078	dGTPase activity
SH83_RS02120	COG0095	Lipoate-protein ligase
SH83_RS02130	COG3343	RNA polymerase activity
SH83_RS02135	COG0504	CTP synthase activity
SH83_RS02140	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SH83_RS02145	COG0814	amino acid
SH83_RS02155	COG1760	l-serine dehydratase
SH83_RS02160	COG1760	l-serine dehydratase
SH83_RS02175	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SH83_RS02180	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SH83_RS02185	COG0254	rRNA binding
SH83_RS02195	COG3764	Sortase (surface protein transpeptidase)
SH83_RS02200	COG1704	LemA family
SH83_RS02205	COG0501	Belongs to the peptidase M48B family
SH83_RS02215	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SH83_RS02235	COG0736	holo-[acyl-carrier-protein] synthase activity
SH83_RS02240	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SH83_RS02245	COG2337	Toxic component of a toxin-antitoxin (TA) module
SH83_RS02250	COG3158	transport of potassium into the cell
SH83_RS02255	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SH83_RS02260	COG0505	Belongs to the CarA family
SH83_RS02265	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SH83_RS02270	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SH83_RS02275	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SH83_RS02280	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SH83_RS02285	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SH83_RS02305	COG2826	transposase and inactivated derivatives, IS30 family
SH83_RS02310	COG0039	L-malate dehydrogenase activity
SH83_RS02315	COG0193	aminoacyl-tRNA hydrolase activity
SH83_RS02320	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SH83_RS02325	COG2244	polysaccharide biosynthetic process
SH83_RS02330	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SH83_RS02340	COG1098	S1 RNA binding domain
SH83_RS02345	COG0037	tRNA processing
SH83_RS02360	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SH83_RS02365	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SH83_RS02370	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SH83_RS02400	COG3104	oligopeptide transport
SH83_RS02450	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SH83_RS02460	COG2188	Transcriptional regulator
SH83_RS02470	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SH83_RS02475	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SH83_RS02490	COG2183	response to ionizing radiation
SH83_RS02495	COG3091	SprT-like family
SH83_RS02500	COG0460	homoserine dehydrogenase
SH83_RS02505	COG0083	homoserine kinase activity
SH83_RS02525	COG3409	Peptidoglycan-binding domain 1 protein
SH83_RS02550	COG3715	PTS system
SH83_RS02555	COG3716	PTS system mannose fructose sorbose family IID component
SH83_RS02565	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SH83_RS02570	COG1713	HD superfamily hydrolase involved in NAD metabolism
SH83_RS02595	COG3933	PFAM sigma-54 factor interaction domain-containing protein
SH83_RS02595	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
SH83_RS02600	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SH83_RS02600	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
SH83_RS02605	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SH83_RS02605	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
SH83_RS02610	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SH83_RS02620	COG0439	Biotin carboxylase
SH83_RS02630	COG0825	malonyl-CoA metabolic process
SH83_RS02635	COG1316	TRANSCRIPTIONal
SH83_RS02645	COG0697	spore germination
SH83_RS02650	COG0588	phosphoglycerate mutase activity
SH83_RS02665	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SH83_RS02675	COG0756	dUTP diphosphatase activity
SH83_RS02695	COG4956	integral membrane protein (PIN domain superfamily)
SH83_RS02700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SH83_RS02705	COG0215	cysteine-tRNA ligase activity
SH83_RS02710	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SH83_RS02715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SH83_RS02730	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SH83_RS02740	COG0250	Participates in transcription elongation, termination and antitermination
SH83_RS02750	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SH83_RS02755	COG0081	regulation of translation
SH83_RS02760	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SH83_RS02765	COG0222	ribosome binding
SH83_RS02785	COG1611	Belongs to the LOG family
SH83_RS02795	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SH83_RS02800	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SH83_RS02805	COG2813	Specifically methylates the guanine in position
SH83_RS02820	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SH83_RS02825	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SH83_RS02830	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SH83_RS02840	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SH83_RS02845	COG3870	Protein conserved in bacteria
SH83_RS02850	COG0470	DNA polymerase III
SH83_RS02855	COG4467	Involved in initiation control of chromosome replication
SH83_RS02870	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SH83_RS02875	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SH83_RS02880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SH83_RS02885	COG3639	organic phosphonate transmembrane transporter activity
SH83_RS02895	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SH83_RS02905	COG1214	PFAM Peptidase M22, glycoprotease
SH83_RS02910	COG0456	acetyltransferase
SH83_RS02915	COG0456	acetyltransferase
SH83_RS02920	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SH83_RS02930	COG0488	(ABC) transporter
SH83_RS02935	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SH83_RS02945	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SH83_RS02950	COG0459	protein refolding
SH83_RS02955	COG0531	amino acid
SH83_RS02960	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SH83_RS02965	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SH83_RS02970	COG1739	Uncharacterized protein family UPF0029
SH83_RS02975	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SH83_RS02990	COG0653	protein targeting
SH83_RS03005	COG0745	RESPONSE REGULATOR receiver
SH83_RS03010	COG5002	protein histidine kinase activity
SH83_RS03020	COG0573	inorganic phosphate transmembrane transporter activity
SH83_RS03025	COG0581	inorganic phosphate transmembrane transporter activity
SH83_RS03030	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SH83_RS03035	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SH83_RS03040	COG0704	Plays a role in the regulation of phosphate uptake
SH83_RS03045	COG1983	PspC domain protein
SH83_RS03050	COG1950	PFAM Membrane protein of
SH83_RS03055	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SH83_RS03060	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SH83_RS03065	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SH83_RS03070	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SH83_RS03080	COG0446	pyridine nucleotide-disulphide oxidoreductase
SH83_RS03100	COG1215	transferase activity, transferring glycosyl groups
SH83_RS03115	COG0492	ferredoxin-NADP+ reductase activity
SH83_RS03125	COG2323	membrane
SH83_RS03135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SH83_RS03145	COG0446	pyridine nucleotide-disulphide oxidoreductase
SH83_RS03155	COG2814	Major facilitator Superfamily
SH83_RS03165	COG0556	nucleotide-excision repair
SH83_RS03170	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SH83_RS03175	COG1854	S-ribosylhomocysteine lyase activity
SH83_RS03180	COG0137	argininosuccinate synthase activity
SH83_RS03185	COG0165	Argininosuccinate lyase
SH83_RS03195	COG1660	Displays ATPase and GTPase activities
SH83_RS03205	COG1481	regulation of sporulation
SH83_RS03215	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SH83_RS03220	COG0740	serine-type endopeptidase activity
SH83_RS03230	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SH83_RS03235	COG2390	Transcriptional regulator
SH83_RS03245	COG0126	phosphoglycerate kinase activity
SH83_RS03250	COG0149	triose-phosphate isomerase activity
SH83_RS03255	COG0148	phosphopyruvate hydratase activity
SH83_RS03270	COG0038	chloride channel
SH83_RS03275	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SH83_RS03285	COG0557	exoribonuclease II activity
SH83_RS03290	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SH83_RS03300	COG0765	amino acid transport
SH83_RS03305	COG1126	abc transporter atp-binding protein
SH83_RS03315	COG0561	phosphatase activity
SH83_RS03320	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SH83_RS03325	COG0280	phosphate acetyltransferase
SH83_RS03330	COG0802	atpase or kinase
SH83_RS03345	COG0708	Exodeoxyribonuclease III
SH83_RS03355	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SH83_RS03360	COG0025	NhaP-type Na H and K H
SH83_RS03385	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SH83_RS03390	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SH83_RS03400	COG0561	phosphatase activity
SH83_RS03410	COG2017	converts alpha-aldose to the beta-anomer
SH83_RS03425	COG0778	Nitroreductase
SH83_RS03450	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SH83_RS03465	COG1393	Belongs to the ArsC family
SH83_RS03480	COG0477	Major facilitator Superfamily
SH83_RS03485	COG0248	Ppx GppA phosphatase
SH83_RS03485	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SH83_RS03490	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SH83_RS03500	COG3475	LICD family
SH83_RS03515	COG2252	PERMEase
SH83_RS03520	COG0028	Belongs to the TPP enzyme family
SH83_RS03525	COG0196	riboflavin kinase activity
SH83_RS03530	COG0028	Belongs to the TPP enzyme family
SH83_RS03535	COG2267	carboxylic ester hydrolase activity
SH83_RS03545	COG2755	lipolytic protein G-D-S-L family
SH83_RS03545	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SH83_RS03550	COG2936	dipeptidyl-peptidase activity
SH83_RS03565	COG0531	amino acid
SH83_RS03590	COG0194	GDP metabolic process
SH83_RS03595	COG0735	belongs to the Fur family
SH83_RS03610	COG0546	phosphoglycolate phosphatase activity
SH83_RS03615	COG0436	Aminotransferase
SH83_RS03620	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SH83_RS03640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SH83_RS03645	COG0765	amino acid transport
SH83_RS03650	COG0765	amino acid transport
SH83_RS03655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SH83_RS03655	COG1263	PTS System
SH83_RS03655	COG2190	(PTS) system
SH83_RS03665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SH83_RS03665	COG1263	PTS System
SH83_RS03670	COG3394	polysaccharide catabolic process
SH83_RS03675	COG0531	amino acid
SH83_RS03685	COG1846	Transcriptional regulator
SH83_RS03715	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SH83_RS03725	COG2076	Multidrug Resistance protein
SH83_RS03740	COG0588	phosphoglycerate mutase activity
SH83_RS03745	COG0569	domain protein
SH83_RS03745	COG0475	glutathione-regulated potassium exporter activity
SH83_RS03750	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
SH83_RS03750	COG0456	acetyltransferase
SH83_RS03755	COG0586	Pfam SNARE associated Golgi protein
SH83_RS03760	COG3973	AAA domain
SH83_RS03765	COG2070	2-Nitropropane dioxygenase
SH83_RS03770	COG1072	(Pantothenic acid kinase))
SH83_RS03775	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SH83_RS03775	COG0519	Catalyzes the synthesis of GMP from XMP
SH83_RS03830	COG1196	nuclear chromosome segregation
SH83_RS03875	COG1396	sequence-specific DNA binding
SH83_RS03885	COG1266	CAAX protease self-immunity
SH83_RS03925	COG2755	lipolytic protein G-D-S-L family
SH83_RS03925	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SH83_RS03930	COG2261	transglycosylase associated protein
SH83_RS03945	COG1302	Protein conserved in bacteria
SH83_RS03975	COG0308	aminopeptidase N
SH83_RS03980	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SH83_RS04030	COG0572	uridine kinase
SH83_RS04045	COG0583	DNA-binding transcription factor activity
SH83_RS04050	COG1053	succinate dehydrogenase
SH83_RS04060	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SH83_RS04065	COG0017	Asparaginyl-tRNA synthetase
SH83_RS04070	COG2502	aspartate--ammonia ligase
SH83_RS04075	COG4690	dipeptidase activity
SH83_RS04095	COG0514	ATP-dependent DNA helicase (RecQ)
SH83_RS04100	COG0564	pseudouridine synthase activity
SH83_RS04105	COG0640	Transcriptional regulator
SH83_RS04155	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SH83_RS04160	COG0527	aspartate kinase activity
SH83_RS04165	COG0367	asparagine synthase
SH83_RS04205	COG2814	Major facilitator Superfamily
SH83_RS04225	COG1278	Cold shock
SH83_RS04230	COG2966	Psort location CytoplasmicMembrane, score
SH83_RS04240	COG1316	TRANSCRIPTIONal
SH83_RS04260	COG1959	2 iron, 2 sulfur cluster binding
SH83_RS04265	COG0028	Belongs to the TPP enzyme family
SH83_RS04270	COG0833	amino acid
SH83_RS04280	COG1428	Deoxynucleoside kinase
SH83_RS04285	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SH83_RS04325	COG4463	regulation of RNA biosynthetic process
SH83_RS04330	COG0542	response to heat
SH83_RS04340	COG0085	RNA polymerase activity
SH83_RS04345	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SH83_RS04350	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SH83_RS04355	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SH83_RS04360	COG0049	tRNA binding
SH83_RS04365	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SH83_RS04370	COG0051	transcription antitermination factor activity, RNA binding
SH83_RS04375	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SH83_RS04380	COG0088	Forms part of the polypeptide exit tunnel
SH83_RS04385	COG0089	rRNA binding
SH83_RS04390	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SH83_RS04395	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SH83_RS04400	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SH83_RS04405	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SH83_RS04410	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SH83_RS04415	COG0255	Belongs to the universal ribosomal protein uL29 family
SH83_RS04420	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SH83_RS04425	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SH83_RS04430	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SH83_RS04435	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SH83_RS04440	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SH83_RS04445	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SH83_RS04450	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SH83_RS04455	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SH83_RS04460	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SH83_RS04465	COG1841	ribosomal large subunit assembly
SH83_RS04470	COG0200	Binds to the 23S rRNA
SH83_RS04480	COG0563	adenylate kinase activity
SH83_RS04485	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SH83_RS04490	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SH83_RS04495	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SH83_RS04500	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SH83_RS04505	COG0202	RNA polymerase activity
SH83_RS04510	COG0203	ribosomal protein L17
SH83_RS04535	COG4939	FMN-binding domain protein
SH83_RS04545	COG1122	ATPase activity
SH83_RS04550	COG1122	ATPase activity
SH83_RS04560	COG0101	tRNA pseudouridine synthase activity
SH83_RS04565	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SH83_RS04570	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SH83_RS04590	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SH83_RS04595	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SH83_RS04600	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SH83_RS04605	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SH83_RS04610	COG0471	metal ion transport
SH83_RS04620	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SH83_RS04630	COG1917	Cupin 2, conserved barrel domain protein
SH83_RS04630	COG4977	sequence-specific DNA binding
SH83_RS04635	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
SH83_RS04640	COG1121	(ABC) transporter
SH83_RS04645	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SH83_RS04650	COG0803	Belongs to the bacterial solute-binding protein 9 family
SH83_RS04660	COG0039	L-malate dehydrogenase activity
SH83_RS04665	COG0471	metal ion transport
SH83_RS04685	COG3052	prosthetic group binding
SH83_RS04725	COG0114	fumarate hydratase activity
SH83_RS04730	COG1053	succinate dehydrogenase
SH83_RS04740	COG0583	DNA-binding transcription factor activity
SH83_RS04745	COG0583	DNA-binding transcription factor activity
SH83_RS04750	COG0281	malic enzyme
SH83_RS04760	COG0531	amino acid
SH83_RS04770	COG0640	Transcriptional regulator
SH83_RS04775	COG4684	Psort location CytoplasmicMembrane, score
SH83_RS04790	COG1271	oxidase subunit
SH83_RS04795	COG1294	oxidase, subunit
SH83_RS04800	COG4988	ABC transporter
SH83_RS04805	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
SH83_RS04820	COG0142	geranyltranstransferase activity
SH83_RS04835	COG1705	Flagellar rod assembly protein muramidase FlgJ
SH83_RS04840	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SH83_RS04845	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
SH83_RS04850	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SH83_RS04860	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SH83_RS04865	COG4851	CamS sex pheromone cAM373 precursor
SH83_RS04870	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SH83_RS04875	COG0154	amidase activity
SH83_RS04880	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SH83_RS04885	COG1597	lipid kinase activity
SH83_RS04890	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SH83_RS04905	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SH83_RS04915	COG1737	Transcriptional regulator
SH83_RS04930	COG1278	Cold shock
SH83_RS04935	COG0673	inositol 2-dehydrogenase activity
SH83_RS04940	COG0513	Belongs to the DEAD box helicase family
SH83_RS04955	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SH83_RS04980	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SH83_RS04990	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SH83_RS05000	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SH83_RS05035	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SH83_RS05035	COG1215	transferase activity, transferring glycosyl groups
SH83_RS05040	COG0110	maltose O-acetyltransferase activity
SH83_RS05070	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SH83_RS05080	COG1088	dTDP-glucose 4,6-dehydratase activity
SH83_RS05085	COG1091	dTDP-4-dehydrorhamnose reductase activity
SH83_RS05095	COG0582	viral genome integration into host DNA
SH83_RS05105	COG0489	protein tyrosine kinase activity
SH83_RS05110	COG4464	protein tyrosine phosphatase activity
SH83_RS05115	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SH83_RS05135	COG1216	Glycosyl transferase, family 2
SH83_RS05145	COG2244	polysaccharide biosynthetic process
SH83_RS05150	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SH83_RS05165	COG2801	Transposase and inactivated derivatives
SH83_RS05190	COG0562	UDP-galactopyranose mutase
SH83_RS05230	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SH83_RS05265	COG2137	regulation of response to DNA damage stimulus
SH83_RS05270	COG3557	Belongs to the UPF0374 family
SH83_RS05290	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SH83_RS05300	COG0628	permease
SH83_RS05305	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SH83_RS05310	COG2610	gluconate transmembrane transporter activity
SH83_RS05315	COG1070	Carbohydrate kinase
SH83_RS05320	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SH83_RS05325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SH83_RS05330	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SH83_RS05360	COG4166	transmembrane transport
SH83_RS05365	COG0601	transmembrane transport
SH83_RS05370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SH83_RS05375	COG0444	Belongs to the ABC transporter superfamily
SH83_RS05380	COG4608	Belongs to the ABC transporter superfamily
SH83_RS05390	COG0582	viral genome integration into host DNA
SH83_RS05395	COG0542	response to heat
SH83_RS05415	COG0438	transferase activity, transferring glycosyl groups
SH83_RS05420	COG0438	transferase activity, transferring glycosyl groups
SH83_RS05430	COG1686	Belongs to the peptidase S11 family
SH83_RS05435	COG0436	Aminotransferase
SH83_RS05440	COG4703	Protein of unknown function (DUF1797)
SH83_RS05445	COG1368	sulfuric ester hydrolase activity
SH83_RS05525	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SH83_RS05545	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SH83_RS05560	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SH83_RS05565	COG0833	amino acid
SH83_RS05570	COG2040	homocysteine
SH83_RS05575	COG0438	transferase activity, transferring glycosyl groups
SH83_RS05585	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SH83_RS05590	COG0477	Major facilitator Superfamily
SH83_RS05605	COG0438	transferase activity, transferring glycosyl groups
SH83_RS05620	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SH83_RS05630	COG0495	leucyl-tRNA aminoacylation
SH83_RS05635	COG2244	polysaccharide biosynthetic process
SH83_RS05640	COG1187	pseudouridine synthase activity
SH83_RS05645	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SH83_RS05650	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SH83_RS05660	COG3842	ATPase activity
SH83_RS05665	COG1175	transmembrane transport
SH83_RS05670	COG0395	ABC-type sugar transport system, permease component
SH83_RS05680	COG0584	glycerophosphoryl diester phosphodiesterase
SH83_RS05685	COG1428	Deoxynucleoside kinase
SH83_RS05690	COG1970	mechanosensitive ion channel activity
SH83_RS05695	COG1511	domain protein
SH83_RS05695	COG1511	domain protein
SH83_RS05725	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SH83_RS05730	COG0789	Transcriptional regulator
SH83_RS05740	COG0697	spore germination
SH83_RS05745	COG0561	phosphatase activity
SH83_RS05765	COG3279	Response regulator of the LytR AlgR family
SH83_RS05785	COG1846	Transcriptional regulator
SH83_RS05800	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SH83_RS05840	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SH83_RS05840	COG0646	methionine synthase
SH83_RS05845	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SH83_RS05855	COG2046	Belongs to the sulfate adenylyltransferase family
SH83_RS05860	COG0529	Catalyzes the synthesis of activated sulfate
SH83_RS05865	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SH83_RS05875	COG3273	potassium ion transport
SH83_RS05875	COG0471	metal ion transport
SH83_RS05880	COG0534	Mate efflux family protein
SH83_RS05900	COG2153	protein acetylation
SH83_RS05905	COG0018	arginyl-trna synthetase
SH83_RS05915	COG1136	(ABC) transporter
SH83_RS05915	COG0577	efflux transmembrane transporter activity
SH83_RS05935	COG1447	Phosphotransferase system cellobiose-specific component IIA
SH83_RS05940	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SH83_RS05945	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SH83_RS05950	COG2723	6-phospho-beta-galactosidase activity
SH83_RS05960	COG1376	ErfK ybiS ycfS ynhG family protein
SH83_RS05965	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SH83_RS05970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SH83_RS05980	COG0436	Aminotransferase
SH83_RS05985	COG1438	arginine binding
SH83_RS05995	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SH83_RS06000	COG3679	Belongs to the UPF0342 family
SH83_RS06005	COG0420	3'-5' exonuclease activity
SH83_RS06010	COG4717	serine-type aminopeptidase activity
SH83_RS06015	COG3481	metal-dependent phosphohydrolase, HD sub domain
SH83_RS06030	COG0583	DNA-binding transcription factor activity
SH83_RS06040	COG0431	NADPH-dependent FMN reductase
SH83_RS06040	COG1053	succinate dehydrogenase
SH83_RS06040	COG3976	FMN-binding domain protein
SH83_RS06060	COG0463	Glycosyl transferase, family 2
SH83_RS06080	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SH83_RS06080	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SH83_RS06085	COG0307	riboflavin synthase, alpha
SH83_RS06090	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SH83_RS06090	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SH83_RS06095	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SH83_RS06110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SH83_RS06120	COG0446	pyridine nucleotide-disulphide oxidoreductase
SH83_RS06150	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SH83_RS06160	COG0537	adenosine 5'-monophosphoramidase activity
SH83_RS06165	COG1131	(ABC) transporter
SH83_RS06170	COG4473	ABC transporter
SH83_RS06175	COG0510	thiamine kinase activity
SH83_RS06180	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SH83_RS06190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SH83_RS06195	COG1674	ftsk spoiiie
SH83_RS06200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SH83_RS06225	COG0719	Fe-S assembly protein
SH83_RS06230	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SH83_RS06240	COG0719	Fe-S assembly protein
SH83_RS06250	COG1120	ATPase activity
SH83_RS06255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SH83_RS06260	COG0716	FMN binding
SH83_RS06275	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SH83_RS06280	COG2223	nitrite transmembrane transporter activity
SH83_RS06285	COG2151	metal-sulfur cluster biosynthetic enzyme
SH83_RS06310	COG2197	response regulator
SH83_RS06335	COG0315	cyclic pyranopterin monophosphate synthase activity
SH83_RS06340	COG1763	Mo-molybdopterin cofactor biosynthetic process
SH83_RS06345	COG0303	'Molybdopterin
SH83_RS06355	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SH83_RS06360	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
SH83_RS06365	COG1140	nitrate reductase beta subunit
SH83_RS06375	COG2181	nitrate reductase activity
SH83_RS06420	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SH83_RS06420	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SH83_RS06425	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SH83_RS06430	COG0237	dephospho-CoA kinase activity
SH83_RS06435	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SH83_RS06440	COG3611	Membrane attachment protein
SH83_RS06445	COG1484	DNA-dependent DNA replication
SH83_RS06450	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SH83_RS06455	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SH83_RS06460	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SH83_RS06465	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SH83_RS06475	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SH83_RS06480	COG0604	alcohol dehydrogenase
SH83_RS06485	COG1733	regulation of RNA biosynthetic process
SH83_RS06495	COG1215	transferase activity, transferring glycosyl groups
SH83_RS06510	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SH83_RS06515	COG1534	Rna-binding protein
SH83_RS06520	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SH83_RS06525	COG1713	HD superfamily hydrolase involved in NAD metabolism
SH83_RS06530	COG0799	negative regulation of ribosome biogenesis
SH83_RS06535	COG2226	methyltransferase
SH83_RS06540	COG1323	Belongs to the UPF0348 family
SH83_RS06550	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SH83_RS06565	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SH83_RS06570	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SH83_RS06575	COG0745	RESPONSE REGULATOR receiver
SH83_RS06580	COG5002	protein histidine kinase activity
SH83_RS06590	COG0419	ATPase involved in DNA repair
SH83_RS06605	COG0706	membrane insertase activity
SH83_RS06610	COG1254	Belongs to the acylphosphatase family
SH83_RS06615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SH83_RS06625	COG1733	regulation of RNA biosynthetic process
SH83_RS06630	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SH83_RS06635	COG0072	phenylalanine-tRNA ligase activity
SH83_RS06635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SH83_RS06640	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SH83_RS06645	COG0572	uridine kinase
SH83_RS06650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SH83_RS06670	COG4841	protein insertion into membrane
SH83_RS06680	COG0768	penicillin binding
SH83_RS06685	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SH83_RS06690	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SH83_RS06695	COG0705	Rhomboid family
SH83_RS06695	COG0457	Tetratricopeptide repeat
SH83_RS06705	COG1940	carbohydrate kinase activity
SH83_RS06725	COG0584	glycerophosphoryl diester phosphodiesterase
SH83_RS06730	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SH83_RS06735	COG0789	Transcriptional regulator
SH83_RS06785	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SH83_RS06795	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SH83_RS06800	COG0006	proline dipeptidase activity
SH83_RS06805	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SH83_RS06810	COG1302	Protein conserved in bacteria
SH83_RS06815	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SH83_RS06820	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SH83_RS06825	COG1570	exodeoxyribonuclease VII activity
SH83_RS06830	COG1722	exodeoxyribonuclease VII activity
SH83_RS06835	COG0142	geranyltranstransferase activity
SH83_RS06840	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SH83_RS06845	COG1438	arginine binding
SH83_RS06850	COG0497	DNA recombination
SH83_RS06865	COG1732	Glycine betaine
SH83_RS06880	COG0194	GDP metabolic process
SH83_RS06885	COG1758	RNA polymerase activity
SH83_RS06890	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SH83_RS06895	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SH83_RS06900	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SH83_RS06905	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SH83_RS06905	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SH83_RS06910	COG0631	protein serine/threonine phosphatase activity
SH83_RS06915	COG2815	serine threonine protein kinase
SH83_RS06915	COG0515	serine threonine protein kinase
SH83_RS06920	COG1162	GTPase activity
SH83_RS06925	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SH83_RS06930	COG1564	THIamine pyrophosphokinase
SH83_RS06940	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SH83_RS06945	COG1302	Protein conserved in bacteria
SH83_RS06950	COG1461	Dihydroxyacetone kinase
SH83_RS06955	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SH83_RS06960	COG0416	fatty acid biosynthetic process
SH83_RS06965	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SH83_RS06970	COG0571	ribonuclease III activity
SH83_RS06975	COG1196	nuclear chromosome segregation
SH83_RS06980	COG0552	protein localization to endoplasmic reticulum
SH83_RS06985	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
SH83_RS06990	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SH83_RS06995	COG0228	four-way junction DNA binding
SH83_RS07000	COG1837	Belongs to the UPF0109 family
SH83_RS07005	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SH83_RS07010	COG0336	Belongs to the RNA methyltransferase TrmD family
SH83_RS07015	COG0335	large ribosomal subunit rRNA binding
SH83_RS07050	COG0512	Glutamine amidotransferase of anthranilate synthase
SH83_RS07050	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SH83_RS07055	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SH83_RS07060	COG0134	indole-3-glycerol-phosphate synthase activity
SH83_RS07065	COG0135	phosphoribosylanthranilate isomerase activity
SH83_RS07070	COG0133	tryptophan synthase activity
SH83_RS07075	COG0159	tryptophan synthase activity
SH83_RS07095	COG1063	alcohol dehydrogenase
SH83_RS07105	COG0300	oxidoreductase activity
SH83_RS07115	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SH83_RS07120	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SH83_RS07125	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SH83_RS07130	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SH83_RS07135	COG1028	Short-chain dehydrogenase reductase Sdr
SH83_RS07140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SH83_RS07155	COG0439	Biotin carboxylase
SH83_RS07170	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SH83_RS07180	COG1811	Na channel or pump
SH83_RS07185	COG0583	DNA-binding transcription factor activity
SH83_RS07190	COG1607	acyl-coa hydrolase
SH83_RS07195	COG1162	GTPase activity
SH83_RS07205	COG0477	Major facilitator Superfamily
SH83_RS07240	COG2826	transposase and inactivated derivatives, IS30 family
SH83_RS07260	COG3397	chitin binding
SH83_RS07275	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
SH83_RS07285	COG3152	Membrane
SH83_RS07290	COG1597	lipid kinase activity
SH83_RS07305	COG2261	transglycosylase associated protein
SH83_RS07310	COG3237	CsbD-like
SH83_RS07325	COG1942	4-Oxalocrotonate Tautomerase
SH83_RS07365	COG0531	amino acid
SH83_RS07370	COG0561	phosphatase activity
SH83_RS07375	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SH83_RS07375	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SH83_RS07395	COG2017	converts alpha-aldose to the beta-anomer
SH83_RS07400	COG1304	FMN binding
SH83_RS07425	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SH83_RS07425	COG1199	ATP-dependent helicase activity
SH83_RS07440	COG0017	Asparaginyl-tRNA synthetase
SH83_RS07455	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SH83_RS07460	COG2011	ABC-type metal ion transport system permease component
SH83_RS07465	COG1464	Belongs to the NlpA lipoprotein family
SH83_RS07480	COG1840	ABC-type Fe3 transport system, periplasmic component
SH83_RS07495	COG3331	DNA recombination
SH83_RS07500	COG4474	Belongs to the UPF0398 family
SH83_RS07505	COG3599	regulation of cell shape
SH83_RS07515	COG0116	Belongs to the methyltransferase superfamily
SH83_RS07520	COG1073	alpha beta
SH83_RS07530	COG1216	Glycosyl transferase, family 2
SH83_RS07550	COG1619	proteins homologs of microcin C7 resistance protein MccF
SH83_RS07575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SH83_RS07590	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SH83_RS07595	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SH83_RS07600	COG0564	pseudouridine synthase activity
SH83_RS07605	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SH83_RS07610	COG0505	Belongs to the CarA family
SH83_RS07615	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SH83_RS07625	COG5646	InterPro IPR014922
SH83_RS07650	COG1131	(ABC) transporter
SH83_RS07655	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
SH83_RS07660	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SH83_RS07670	COG1307	EDD domain protein, DegV family
SH83_RS07735	COG1113	amino acid transport
SH83_RS07750	COG1620	l-lactate permease
SH83_RS07760	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SH83_RS07770	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SH83_RS07785	COG1846	Transcriptional regulator
SH83_RS07790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SH83_RS07830	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SH83_RS07835	COG1227	inorganic diphosphatase activity
SH83_RS07840	COG0583	DNA-binding transcription factor activity
SH83_RS07850	COG0187	DNA topoisomerase II activity
SH83_RS07855	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SH83_RS07865	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SH83_RS07870	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SH83_RS07875	COG4974	Belongs to the 'phage' integrase family
SH83_RS07880	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SH83_RS07885	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SH83_RS07890	COG0758	DNA mediated transformation
SH83_RS07895	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SH83_RS07900	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SH83_RS07910	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SH83_RS07915	COG0583	DNA-binding transcription factor activity
SH83_RS07930	COG2814	Major facilitator Superfamily
SH83_RS07935	COG0793	Belongs to the peptidase S41A family
SH83_RS07935	COG3409	Peptidoglycan-binding domain 1 protein
SH83_RS07940	COG4479	Belongs to the UPF0346 family
SH83_RS07945	COG4698	Protein conserved in bacteria
SH83_RS07950	COG2755	lipolytic protein G-D-S-L family
SH83_RS07955	COG1307	EDD domain protein, DegV family
SH83_RS07960	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SH83_RS07965	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SH83_RS07970	COG0488	(ABC) transporter
SH83_RS07980	COG0617	tRNA 3'-terminal CCA addition
SH83_RS07985	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SH83_RS07990	COG0561	phosphatase activity
SH83_RS07995	COG0457	Tetratricopeptide repeat
SH83_RS08010	COG1160	GTP binding
SH83_RS08015	COG0539	negative regulation of cytoplasmic translation
SH83_RS08020	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SH83_RS08030	COG0514	ATP-dependent DNA helicase (RecQ)
SH83_RS08040	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SH83_RS08045	COG1187	pseudouridine synthase activity
SH83_RS08050	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SH83_RS08055	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SH83_RS08065	COG4974	Belongs to the 'phage' integrase family
SH83_RS08070	COG2996	Protein conserved in bacteria
SH83_RS08085	COG0205	6-phosphofructokinase activity
SH83_RS08090	COG0587	DNA-directed DNA polymerase activity
SH83_RS08100	COG0542	response to heat
SH83_RS08110	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SH83_RS08115	COG2384	SAM-dependent methyltransferase
SH83_RS08140	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SH83_RS08140	COG0574	Belongs to the PEP-utilizing enzyme family
SH83_RS08150	COG1846	Transcriptional regulator
SH83_RS08170	COG2217	Heavy metal translocating P-type atpase
SH83_RS08175	COG0148	phosphopyruvate hydratase activity
SH83_RS08180	COG0477	Major facilitator Superfamily
SH83_RS08190	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SH83_RS08195	COG0446	pyridine nucleotide-disulphide oxidoreductase
SH83_RS08200	COG1349	DNA-binding transcription factor activity
SH83_RS08210	COG1393	Belongs to the ArsC family
SH83_RS08250	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SH83_RS08255	COG0546	phosphoglycolate phosphatase activity
SH83_RS08285	COG0583	DNA-binding transcription factor activity
SH83_RS08290	COG0604	alcohol dehydrogenase
SH83_RS08300	COG0446	pyridine nucleotide-disulphide oxidoreductase
SH83_RS08305	COG2197	response regulator
SH83_RS08310	COG4585	Histidine kinase
SH83_RS08320	COG1131	(ABC) transporter
SH83_RS08330	COG0519	Catalyzes the synthesis of GMP from XMP
SH83_RS08345	COG1131	(ABC) transporter
SH83_RS08365	COG1131	(ABC) transporter
SH83_RS08370	COG1725	Transcriptional regulator
SH83_RS08380	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SH83_RS08385	COG0358	DNA primase activity
SH83_RS08390	COG0751	glycine-tRNA ligase activity
SH83_RS08395	COG0752	glycyl-tRNA synthetase alpha subunit
SH83_RS08400	COG1381	Involved in DNA repair and RecF pathway recombination
SH83_RS08405	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SH83_RS08410	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SH83_RS08415	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SH83_RS08420	COG1702	phosphate starvation-inducible protein PhoH
SH83_RS08425	COG1610	YqeY-like protein
SH83_RS08430	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SH83_RS08435	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SH83_RS08445	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SH83_RS08455	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SH83_RS08465	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SH83_RS08470	COG0124	histidyl-tRNA synthetase
SH83_RS08475	COG4991	sh3 domain protein
SH83_RS08475	COG3103	Sh3 type 3 domain protein
SH83_RS08475	COG0860	N-Acetylmuramoyl-L-alanine amidase
SH83_RS08480	COG3001	Fructosamine kinase
SH83_RS08485	COG0546	phosphoglycolate phosphatase activity
SH83_RS08490	COG1490	D-aminoacyl-tRNA deacylase activity
SH83_RS08495	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SH83_RS08505	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SH83_RS08510	COG2264	protein methyltransferase activity
SH83_RS08515	COG2094	Belongs to the DNA glycosylase MPG family
SH83_RS08530	COG0481	GTPase activity
SH83_RS08535	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SH83_RS08540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SH83_RS08545	COG1696	Membrane protein involved in D-alanine export
SH83_RS08550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SH83_RS08560	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SH83_RS08565	COG0484	heat shock protein binding
SH83_RS08570	COG0443	Heat shock 70 kDa protein
SH83_RS08575	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SH83_RS08580	COG1420	regulation of RNA biosynthetic process
SH83_RS08585	COG3527	Alpha-acetolactate decarboxylase
SH83_RS08590	COG0196	riboflavin kinase activity
SH83_RS08595	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SH83_RS08600	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SH83_RS08605	COG0287	Prephenate dehydrogenase
SH83_RS08610	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SH83_RS08620	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SH83_RS08625	COG0738	Major facilitator superfamily
SH83_RS08630	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SH83_RS08635	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SH83_RS08645	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SH83_RS08650	COG0195	Participates in both transcription termination and antitermination
SH83_RS08655	COG0779	Required for maturation of 30S ribosomal subunits
SH83_RS08660	COG2176	DNA-directed DNA polymerase activity
SH83_RS08665	COG0442	prolyl-tRNA aminoacylation
SH83_RS08670	COG0750	zinc metalloprotease
SH83_RS08675	COG4589	Belongs to the CDS family
SH83_RS08680	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SH83_RS08685	COG0233	cytoplasmic translational termination
SH83_RS08690	COG0528	UMP kinase activity
SH83_RS08695	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SH83_RS08700	COG0052	Belongs to the universal ribosomal protein uS2 family
SH83_RS08710	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SH83_RS08715	COG2827	Endonuclease containing a URI domain
SH83_RS08720	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SH83_RS08725	COG0204	Acyl-transferase
SH83_RS08730	COG3763	UPF0154 protein
SH83_RS08735	COG4224	UPF0291 protein
SH83_RS08740	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SH83_RS08750	COG3425	synthase
SH83_RS08765	COG0463	Glycosyl transferase, family 2
SH83_RS08780	COG1316	TRANSCRIPTIONal
SH83_RS08785	COG1116	anion transmembrane transporter activity
SH83_RS08795	COG0772	Belongs to the SEDS family
SH83_RS09010	COG1396	sequence-specific DNA binding
SH83_RS09055	COG0393	Putative heavy-metal-binding
SH83_RS09075	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SH83_RS09080	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SH83_RS09080	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SH83_RS09085	COG5416	Lipopolysaccharide assembly protein A domain
SH83_RS09090	COG0300	oxidoreductase activity
SH83_RS09095	COG1234	tRNA 3'-trailer cleavage
SH83_RS09105	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SH83_RS09110	COG1349	DNA-binding transcription factor activity
SH83_RS09115	COG1105	Belongs to the carbohydrate kinase PfkB family
SH83_RS09120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SH83_RS09120	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SH83_RS09120	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SH83_RS09125	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SH83_RS09150	COG0297	glycogen (starch) synthase activity
SH83_RS09160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SH83_RS09170	COG0489	protein tyrosine kinase activity
SH83_RS09180	COG0322	excinuclease ABC activity
SH83_RS09185	COG1126	abc transporter atp-binding protein
SH83_RS09190	COG0765	amino acid transport
SH83_RS09210	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SH83_RS09215	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SH83_RS09220	COG0544	peptidyl-prolyl cis-trans isomerase activity
SH83_RS09225	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SH83_RS09250	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SH83_RS09255	COG0268	Binds directly to 16S ribosomal RNA
SH83_RS09260	COG1466	dna polymerase III delta subunit
SH83_RS09265	COG2333	competence protein COMEC
SH83_RS09265	COG0658	competence protein
SH83_RS09270	COG2131	deaminase
SH83_RS09275	COG1596	polysaccharide export
SH83_RS09275	COG1555	photosystem II stabilization
SH83_RS09280	COG3480	Lon protease (S16) C-terminal proteolytic domain
SH83_RS09285	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SH83_RS09290	COG0742	ribosomal rna small subunit methyltransferase
SH83_RS09295	COG4471	UPF0298 protein
SH83_RS09300	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
SH83_RS09305	COG0772	Belongs to the SEDS family
SH83_RS09340	COG1217	gtp-binding protein TYPA
SH83_RS09345	COG0483	inositol monophosphate 1-phosphatase activity
SH83_RS09350	COG4476	Belongs to the UPF0223 family
SH83_RS09355	COG0039	L-malate dehydrogenase activity
SH83_RS09380	COG0242	peptide deformylase activity
SH83_RS09390	COG5503	Protein of unknown function (DUF1447)
SH83_RS09395	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SH83_RS09400	COG1597	lipid kinase activity
SH83_RS09410	COG3584	3D domain protein
SH83_RS09410	COG1388	LysM domain
SH83_RS09415	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SH83_RS09420	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SH83_RS09455	COG0569	domain protein
SH83_RS09460	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SH83_RS09465	COG0482	sulfurtransferase activity
SH83_RS09475	COG1104	cysteine desulfurase activity
SH83_RS09480	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SH83_RS09490	COG0494	nUDIX hydrolase
SH83_RS09495	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SH83_RS09500	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SH83_RS09505	COG3599	regulation of cell shape
SH83_RS09515	COG0762	integral membrane protein
SH83_RS09520	COG1799	cell septum assembly
SH83_RS09535	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SH83_RS09540	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SH83_RS09545	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SH83_RS09550	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SH83_RS09555	COG0768	penicillin binding
SH83_RS09565	COG0275	rRNA processing
SH83_RS09570	COG2001	Belongs to the MraZ family
SH83_RS09590	COG1674	ftsk spoiiie
SH83_RS09595	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SH83_RS09610	COG1114	Component of the transport system for branched-chain amino acids
SH83_RS09620	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SH83_RS09625	COG0628	permease
SH83_RS09635	COG2706	6-phosphogluconolactonase activity
SH83_RS09640	COG3142	Participates in the control of copper homeostasis
SH83_RS09645	COG0564	pseudouridine synthase activity
SH83_RS09650	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SH83_RS09655	COG2357	RelA SpoT domain protein
SH83_RS09665	COG1164	Oligoendopeptidase f
SH83_RS09675	COG4862	establishment of competence for transformation
SH83_RS09680	COG1393	Belongs to the ArsC family
SH83_RS09685	COG1234	tRNA 3'-trailer cleavage
SH83_RS09840	COG1098	S1 RNA binding domain
SH83_RS09850	COG0586	Pfam SNARE associated Golgi protein
SH83_RS09860	COG0647	UMP catabolic process
SH83_RS09865	COG4470	Protein conserved in bacteria
SH83_RS09870	COG0737	Belongs to the 5'-nucleotidase family
SH83_RS09885	COG1113	amino acid transport
SH83_RS09890	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SH83_RS09895	COG0827	DNA restriction-modification system
SH83_RS09925	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SH83_RS09935	COG0217	transcriptional regulatory protein
SH83_RS09950	COG1609	Transcriptional regulator
SH83_RS09955	COG0006	proline dipeptidase activity
SH83_RS09960	COG0789	Transcriptional regulator
SH83_RS09975	COG0668	transmembrane transport
SH83_RS09980	COG1473	amidohydrolase
SH83_RS09985	COG2171	N-acyltransferase activity
SH83_RS09990	COG0517	IMP dehydrogenase activity
SH83_RS10000	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SH83_RS10005	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SH83_RS10010	COG1719	4-vinyl reductase, 4VR
SH83_RS10015	COG3118	belongs to the thioredoxin family
SH83_RS10020	COG1193	negative regulation of DNA recombination
SH83_RS10030	COG3906	Belongs to the UPF0473 family
SH83_RS10035	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SH83_RS10040	COG4472	Bacterial protein of unknown function (DUF965)
SH83_RS10045	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SH83_RS10050	COG0513	Belongs to the DEAD box helicase family
SH83_RS10055	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SH83_RS10060	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SH83_RS10065	COG1862	Preprotein translocase
SH83_RS10070	COG0343	queuine tRNA-ribosyltransferase activity
SH83_RS10075	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SH83_RS10080	COG2255	four-way junction helicase activity
SH83_RS10085	COG0632	four-way junction helicase activity
SH83_RS10115	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SH83_RS10120	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SH83_RS10125	COG1692	metallophosphoesterase
SH83_RS10130	COG1418	mRNA catabolic process
SH83_RS10135	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SH83_RS10140	COG1058	Belongs to the CinA family
SH83_RS10140	COG1546	Belongs to the CinA family
SH83_RS10145	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SH83_RS10150	COG1426	Protein conserved in bacteria
SH83_RS10155	COG0612	Peptidase, M16
SH83_RS10160	COG0612	Peptidase, M16
SH83_RS10165	COG0527	aspartate kinase activity
SH83_RS10175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SH83_RS10180	COG1126	abc transporter atp-binding protein
SH83_RS10185	COG0765	amino acid transport
SH83_RS10190	COG2894	cell division
SH83_RS10195	COG0850	regulation of cytokinetic process
SH83_RS10205	COG1792	Involved in formation and maintenance of cell shape
SH83_RS10210	COG1077	Cell shape determining protein MreB Mrl
SH83_RS10215	COG2003	Belongs to the UPF0758 family
SH83_RS10220	COG0285	dihydrofolate synthase activity
SH83_RS10225	COG0525	valine-tRNA ligase activity
SH83_RS10240	COG0301	tRNA thio-modification
SH83_RS10245	COG1104	cysteine desulfurase activity
SH83_RS10255	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
SH83_RS10260	COG1956	GAF domain-containing protein
SH83_RS10265	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SH83_RS10270	COG4493	Belongs to the UPF0637 family
SH83_RS10290	COG2918	glutathione biosynthetic process
SH83_RS10290	COG0189	ligase activity
SH83_RS10295	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SH83_RS10310	COG0589	response to stress
SH83_RS10330	COG1181	Belongs to the D-alanine--D-alanine ligase family
SH83_RS10350	COG1464	Belongs to the NlpA lipoprotein family
SH83_RS10355	COG2011	ABC-type metal ion transport system permease component
SH83_RS10360	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SH83_RS10365	COG0509	glycine decarboxylation via glycine cleavage system
SH83_RS10370	COG0772	Belongs to the SEDS family
SH83_RS10380	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SH83_RS10385	COG1077	Cell shape determining protein MreB Mrl
SH83_RS10395	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SH83_RS10400	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SH83_RS10405	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SH83_RS10410	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SH83_RS10415	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SH83_RS10420	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SH83_RS10425	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SH83_RS10430	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SH83_RS10435	COG0356	it plays a direct role in the translocation of protons across the membrane
SH83_RS10440	COG2233	PERMEase
SH83_RS10455	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SH83_RS10460	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SH83_RS10465	COG0009	L-threonylcarbamoyladenylate synthase
SH83_RS10470	COG2890	protein-(glutamine-N5) methyltransferase activity
SH83_RS10475	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SH83_RS10480	COG1435	thymidine kinase activity
SH83_RS10485	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SH83_RS10490	COG3442	glutamine amidotransferase
SH83_RS10495	COG1482	cell wall glycoprotein biosynthetic process
SH83_RS10500	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SH83_RS10510	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SH83_RS10525	COG1132	(ABC) transporter
SH83_RS10540	COG0726	polysaccharide deacetylase
SH83_RS10670	COG2868	ribosomal protein
SH83_RS10785	COG3935	DnaD domain protein
SH83_RS10915	COG4932	domain protein
SH83_RS10915	COG4886	Leucine-rich repeat (LRR) protein
SH83_RS10960	COG1132	(ABC) transporter
SH83_RS10970	COG0577	efflux transmembrane transporter activity
SH83_RS10970	COG1136	(ABC) transporter
SH83_RS10980	COG0166	Belongs to the GPI family
SH83_RS10985	COG4975	Glucose uptake
SH83_RS10990	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SH83_RS10995	COG3850	Histidine kinase
SH83_RS10995	COG5002	protein histidine kinase activity
SH83_RS11000	COG0745	RESPONSE REGULATOR receiver
SH83_RS11005	COG2848	UPF0210 protein
SH83_RS11010	COG3830	Belongs to the UPF0237 family
SH83_RS11035	COG0477	Major facilitator Superfamily
SH83_RS11055	COG0791	NLP P60 protein
SH83_RS11060	COG1522	sequence-specific DNA binding
SH83_RS11080	COG0488	(ABC) transporter
SH83_RS11105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SH83_RS11105	COG1263	PTS System
SH83_RS11105	COG2190	(PTS) system
SH83_RS11110	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SH83_RS11115	COG1307	EDD domain protein, DegV family
SH83_RS11125	COG2873	o-acetylhomoserine
SH83_RS11130	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SH83_RS11145	COG4120	Belongs to the binding-protein-dependent transport system permease family
SH83_RS11155	COG0446	pyridine nucleotide-disulphide oxidoreductase
SH83_RS11165	COG2084	Dehydrogenase
SH83_RS11170	COG0861	Integral membrane protein TerC family
SH83_RS11175	COG0110	maltose O-acetyltransferase activity
SH83_RS11180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SH83_RS11185	COG0140	phosphoribosyl-ATP diphosphatase activity
SH83_RS11190	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SH83_RS11195	COG0107	imidazoleglycerol-phosphate synthase activity
SH83_RS11200	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SH83_RS11205	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SH83_RS11210	COG0131	Imidazoleglycerol-phosphate dehydratase
SH83_RS11215	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SH83_RS11220	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SH83_RS11225	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SH83_RS11230	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SH83_RS11255	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SH83_RS11270	COG3548	integral membrane protein
SH83_RS11290	COG1368	sulfuric ester hydrolase activity
SH83_RS11295	COG0584	glycerophosphoryl diester phosphodiesterase
SH83_RS11305	COG0492	ferredoxin-NADP+ reductase activity
SH83_RS11315	COG4932	domain protein
SH83_RS11320	COG2326	polyphosphate kinase activity
SH83_RS11325	COG0778	Nitroreductase
SH83_RS11335	COG0328	RNA-DNA hybrid ribonuclease activity
SH83_RS11340	COG4975	Glucose uptake
SH83_RS11355	COG1349	DNA-binding transcription factor activity
SH83_RS11360	COG1882	Formate acetyltransferase
SH83_RS11380	COG1609	Transcriptional regulator
SH83_RS11385	COG1737	Transcriptional regulator
SH83_RS11390	COG0673	inositol 2-dehydrogenase activity
SH83_RS11395	COG0673	inositol 2-dehydrogenase activity
SH83_RS11400	COG0025	NhaP-type Na H and K H
SH83_RS11405	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SH83_RS11410	COG1335	isochorismatase
SH83_RS11420	COG1131	(ABC) transporter
SH83_RS11425	COG1725	Transcriptional regulator
SH83_RS11470	COG0028	Belongs to the TPP enzyme family
SH83_RS11480	COG1073	alpha beta
SH83_RS11485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SH83_RS11490	COG0626	cystathionine gamma-synthase activity
SH83_RS11520	COG0095	Lipoate-protein ligase
SH83_RS11525	COG1705	Flagellar rod assembly protein muramidase FlgJ
SH83_RS11530	COG0589	response to stress
SH83_RS11535	COG0564	pseudouridine synthase activity
SH83_RS11550	COG4640	response to antibiotic
SH83_RS11555	COG1396	sequence-specific DNA binding
SH83_RS11570	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SH83_RS11580	COG2188	Transcriptional regulator
SH83_RS11585	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SH83_RS11595	COG1418	mRNA catabolic process
SH83_RS11625	COG1253	flavin adenine dinucleotide binding
SH83_RS11630	COG1780	Probably involved in ribonucleotide reductase function
SH83_RS11635	COG0025	NhaP-type Na H and K H
SH83_RS11640	COG2814	Major facilitator Superfamily
SH83_RS11645	COG0789	Transcriptional regulator
SH83_RS11650	COG0604	alcohol dehydrogenase
SH83_RS11660	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SH83_RS11670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SH83_RS11675	COG0436	Aminotransferase
SH83_RS11680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SH83_RS11695	COG0583	DNA-binding transcription factor activity
SH83_RS11700	COG0702	epimerase
SH83_RS11710	COG1074	ATP-dependent DNA helicase activity
SH83_RS11715	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
SH83_RS11725	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SH83_RS11730	COG0284	orotidine-5'-phosphate decarboxylase activity
SH83_RS11735	COG0167	dihydroorotate dehydrogenase activity
SH83_RS11740	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SH83_RS11745	COG0505	Belongs to the CarA family
SH83_RS11750	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SH83_RS11755	COG0540	Belongs to the ATCase OTCase family
SH83_RS11760	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SH83_RS11765	COG2508	Transcriptional regulator
SH83_RS11770	COG2233	PERMEase
SH83_RS11775	COG2252	PERMEase
SH83_RS11795	COG1215	transferase activity, transferring glycosyl groups
SH83_RS11805	COG0151	Belongs to the GarS family
SH83_RS11810	COG0138	bifunctional purine biosynthesis protein purh
SH83_RS11815	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SH83_RS11820	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SH83_RS11830	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SH83_RS11835	COG0047	phosphoribosylformylglycinamidine synthase activity
SH83_RS11840	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SH83_RS11845	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SH83_RS11850	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SH83_RS11860	COG3976	FMN-binding domain protein
SH83_RS11860	COG0431	NADPH-dependent FMN reductase
SH83_RS11860	COG1053	succinate dehydrogenase
SH83_RS11865	COG1053	succinate dehydrogenase
SH83_RS11865	COG3976	FMN-binding domain protein
SH83_RS11865	COG0431	NADPH-dependent FMN reductase
SH83_RS11870	COG0095	Lipoate-protein ligase
SH83_RS11875	COG2365	Tyrosine phosphatase family
SH83_RS11895	COG1136	(ABC) transporter
SH83_RS11910	COG1725	Transcriptional regulator
SH83_RS11915	COG1131	(ABC) transporter
SH83_RS11925	COG0589	response to stress
SH83_RS11935	COG2246	polysaccharide biosynthetic process
SH83_RS11955	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SH83_RS11975	COG0366	Alpha amylase catalytic
SH83_RS11985	COG0561	phosphatase activity
SH83_RS11995	COG0110	maltose O-acetyltransferase activity
SH83_RS12000	COG0494	nUDIX hydrolase
SH83_RS12035	COG1827	regulation of RNA biosynthetic process
SH83_RS12040	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SH83_RS12045	COG1309	transcriptional regulator
SH83_RS12055	COG1131	(ABC) transporter
SH83_RS12060	COG3048	D-serine ammonia-lyase activity
SH83_RS12065	COG2723	6-phospho-beta-galactosidase activity
SH83_RS12070	COG2723	6-phospho-beta-galactosidase activity
SH83_RS12075	COG1447	Phosphotransferase system cellobiose-specific component IIA
SH83_RS12080	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SH83_RS12085	COG2188	Transcriptional regulator
SH83_RS12090	COG1216	Glycosyl transferase, family 2
SH83_RS12105	COG0561	phosphatase activity
SH83_RS12110	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SH83_RS12140	COG0716	FMN binding
SH83_RS12160	COG0710	3-dehydroquinate dehydratase activity
SH83_RS12165	COG0531	amino acid
SH83_RS12210	COG4720	Psort location CytoplasmicMembrane, score
SH83_RS12215	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SH83_RS12230	COG4990	cell redox homeostasis
SH83_RS12255	COG1811	Na channel or pump
SH83_RS12260	COG0789	Transcriptional regulator
SH83_RS12260	COG4978	Transcriptional regulator
SH83_RS12280	COG0577	efflux transmembrane transporter activity
SH83_RS12285	COG1136	(ABC) transporter
SH83_RS12325	COG2814	Major facilitator Superfamily
SH83_RS12335	COG2814	Major facilitator Superfamily
SH83_RS12345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SH83_RS12350	COG2855	membrane
SH83_RS12355	COG0583	DNA-binding transcription factor activity
SH83_RS12365	COG0438	transferase activity, transferring glycosyl groups
SH83_RS12380	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SH83_RS12390	COG4152	abc transporter atp-binding protein
SH83_RS12400	COG4221	oxidoreductase activity
SH83_RS12415	COG0789	Transcriptional regulator
SH83_RS12435	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SH83_RS12460	COG0456	acetyltransferase
SH83_RS12485	COG0583	DNA-binding transcription factor activity
SH83_RS12495	COG1063	alcohol dehydrogenase
SH83_RS12500	COG1028	Short-chain dehydrogenase reductase Sdr
SH83_RS12510	COG0589	response to stress
SH83_RS12515	COG0110	maltose O-acetyltransferase activity
SH83_RS12520	COG1011	Hydrolase
SH83_RS12535	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SH83_RS12545	COG0667	Aldo Keto reductase
SH83_RS12550	COG1132	(ABC) transporter
SH83_RS12555	COG1132	(ABC) transporter
SH83_RS12560	COG2814	Major facilitator Superfamily
SH83_RS12575	COG1511	domain protein
SH83_RS12575	COG1511	domain protein
SH83_RS12585	COG0640	Transcriptional regulator
SH83_RS12615	COG0488	(ABC) transporter
SH83_RS12620	COG0561	phosphatase activity
SH83_RS12630	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SH83_RS12645	COG2270	Major facilitator Superfamily
SH83_RS12685	COG2200	EAL domain
SH83_RS12695	COG1328	CTP reductase activity
SH83_RS12705	COG0242	peptide deformylase activity
SH83_RS12715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SH83_RS12735	COG0583	DNA-binding transcription factor activity
SH83_RS12745	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SH83_RS12805	COG0697	spore germination
SH83_RS12830	COG1940	carbohydrate kinase activity
SH83_RS12835	COG1132	(ABC) transporter
SH83_RS12845	COG0778	Nitroreductase
SH83_RS12850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SH83_RS12850	COG1263	PTS System
SH83_RS12850	COG2190	(PTS) system
SH83_RS12855	COG1116	anion transmembrane transporter activity
SH83_RS12860	COG4120	Belongs to the binding-protein-dependent transport system permease family
SH83_RS12890	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SH83_RS12890	COG0617	tRNA 3'-terminal CCA addition
SH83_RS12890	COG3620	sequence-specific DNA binding
SH83_RS12895	COG0410	ABC transporter
SH83_RS12910	COG0559	Belongs to the binding-protein-dependent transport system permease family
SH83_RS12925	COG5549	protein import
SH83_RS12925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SH83_RS12930	COG2246	polysaccharide biosynthetic process
SH83_RS12940	COG1914	H( )-stimulated, divalent metal cation uptake system
SH83_RS12960	COG0640	Transcriptional regulator
SH83_RS12975	COG1136	(ABC) transporter
SH83_RS12975	COG0577	efflux transmembrane transporter activity
SH83_RS13010	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SH83_RS13015	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SH83_RS13020	COG2723	6-phospho-beta-galactosidase activity
SH83_RS13030	COG0789	Transcriptional regulator
SH83_RS13035	COG0741	lytic transglycosylase activity
SH83_RS13055	COG0803	Belongs to the bacterial solute-binding protein 9 family
SH83_RS13080	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SH83_RS13095	COG4221	oxidoreductase activity
SH83_RS13140	COG1132	(ABC) transporter
SH83_RS13145	COG1132	(ABC) transporter
SH83_RS13155	COG1473	amidohydrolase
SH83_RS13160	COG1028	Short-chain dehydrogenase reductase Sdr
SH83_RS13175	COG0531	amino acid
SH83_RS13205	COG2217	Heavy metal translocating P-type atpase
SH83_RS13265	COG1063	alcohol dehydrogenase
SH83_RS13305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SH83_RS13310	COG1733	regulation of RNA biosynthetic process
SH83_RS13315	COG2814	Major facilitator Superfamily
SH83_RS13325	COG0367	asparagine synthase
SH83_RS13330	COG3279	Response regulator of the LytR AlgR family
SH83_RS13345	COG1309	transcriptional regulator
SH83_RS13355	COG1012	belongs to the aldehyde dehydrogenase family
SH83_RS13370	COG1733	regulation of RNA biosynthetic process
SH83_RS13375	COG0300	oxidoreductase activity
SH83_RS13395	COG4989	oxidoreductase activity
SH83_RS13400	COG0477	Major facilitator Superfamily
SH83_RS13410	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SH83_RS13415	COG1120	ATPase activity
SH83_RS13420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SH83_RS13425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SH83_RS13430	COG1309	transcriptional regulator
SH83_RS13440	COG4221	oxidoreductase activity
SH83_RS13445	COG0110	maltose O-acetyltransferase activity
SH83_RS13455	COG0481	GTPase activity
SH83_RS13465	COG2816	NAD+ diphosphatase activity
SH83_RS13475	COG1053	succinate dehydrogenase
SH83_RS13475	COG3976	FMN-binding domain protein
SH83_RS13475	COG0431	NADPH-dependent FMN reductase
SH83_RS13485	COG0783	Belongs to the Dps family
SH83_RS13495	COG2723	6-phospho-beta-galactosidase activity
SH83_RS13500	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SH83_RS13525	COG0789	Transcriptional regulator
SH83_RS13535	COG3152	Membrane
SH83_RS13545	COG0693	protein deglycase activity
SH83_RS13595	COG1064	alcohol dehydrogenase
SH83_RS13600	COG0656	L-ascorbic acid biosynthetic process
SH83_RS13615	COG4221	oxidoreductase activity
SH83_RS13620	COG0583	DNA-binding transcription factor activity
SH83_RS13630	COG4974	Belongs to the 'phage' integrase family
SH83_RS13665	COG0588	phosphoglycerate mutase activity
SH83_RS13670	COG0628	permease
SH83_RS13675	COG1940	carbohydrate kinase activity
SH83_RS13675	COG1846	Transcriptional regulator
SH83_RS13685	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SH83_RS13695	COG2815	serine threonine protein kinase
SH83_RS13695	COG0515	serine threonine protein kinase
SH83_RS13740	COG1247	-acetyltransferase
SH83_RS13745	COG1686	Belongs to the peptidase S11 family
SH83_RS13765	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SH83_RS13770	COG0516	GMP reductase activity
SH83_RS13770	COG0517	IMP dehydrogenase activity
SH83_RS13780	COG0012	GTP binding
SH83_RS13785	COG4481	Protein conserved in bacteria
SH83_RS13790	COG1475	DNA binding
SH83_RS13795	COG1192	Involved in chromosome partitioning
SH83_RS13805	COG0357	Ribosomal RNA small subunit methyltransferase G
SH83_RS13810	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SH83_RS13820	COG0583	DNA-binding transcription factor activity
SH83_RS13825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SH83_RS13830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SH83_RS13835	COG0765	amino acid transport
SH83_RS13840	COG1126	abc transporter atp-binding protein
SH83_RS13845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SH83_RS13875	COG1263	PTS System
SH83_RS13875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SH83_RS13875	COG2190	(PTS) system
SH83_RS13880	COG0366	Alpha amylase catalytic
SH83_RS13885	COG1609	Transcriptional regulator
SH83_RS13900	COG0390	transport system, permease component
SH83_RS13905	COG4619	ABC transporter
SH83_RS13910	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SH83_RS13925	COG0561	phosphatase activity
SH83_RS13935	COG0383	alpha-mannosidase activity
SH83_RS13940	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SH83_RS13940	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SH83_RS13940	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SH83_RS13945	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SH83_RS13950	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SH83_RS13950	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SH83_RS13950	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SH83_RS13955	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SH83_RS13955	COG3711	transcriptional antiterminator
SH83_RS13970	COG2190	(PTS) system
SH83_RS13970	COG1263	PTS System
SH83_RS13970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SH83_RS14000	COG0735	belongs to the Fur family
SH83_RS14025	COG1380	Effector of murein hydrolase LrgA
SH83_RS14035	COG1307	EDD domain protein, DegV family
SH83_RS14045	COG2738	Putative neutral zinc metallopeptidase
SH83_RS14050	COG1233	COG1233 Phytoene dehydrogenase and related
SH83_RS14055	COG1562	ergosterol biosynthetic process
SH83_RS14065	COG1929	Belongs to the glycerate kinase type-1 family
SH83_RS14080	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SH83_RS14085	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SH83_RS14090	COG0516	GMP reductase activity
SH83_RS14095	COG2365	Tyrosine phosphatase family
SH83_RS14100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SH83_RS14110	COG0531	amino acid
SH83_RS14115	COG3158	transport of potassium into the cell
SH83_RS14120	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SH83_RS14125	COG0628	permease
SH83_RS14130	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SH83_RS14145	COG1272	protein, Hemolysin III
SH83_RS14150	COG0640	Transcriptional regulator
SH83_RS14175	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SH83_RS14185	COG0302	gtp cyclohydrolase
SH83_RS14190	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SH83_RS14210	COG0803	Belongs to the bacterial solute-binding protein 9 family
SH83_RS14215	COG2814	Major facilitator Superfamily
SH83_RS14245	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SH83_RS14250	COG1882	Formate acetyltransferase
SH83_RS14255	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SH83_RS14265	COG2151	metal-sulfur cluster biosynthetic enzyme
SH83_RS14270	COG4989	oxidoreductase activity
SH83_RS14305	COG2217	Heavy metal translocating P-type atpase
SH83_RS14315	COG2315	Protein conserved in bacteria
SH83_RS14325	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SH83_RS14330	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SH83_RS14340	COG1757	Na H antiporter
SH83_RS14345	COG1113	amino acid transport
SH83_RS14355	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SH83_RS14370	COG1393	Belongs to the ArsC family
SH83_RS14375	COG3189	MarR family transcriptional regulator
SH83_RS14385	COG1194	a g-specific adenine glycosylase
SH83_RS14400	COG0071	Belongs to the small heat shock protein (HSP20) family
SH83_RS14420	COG0697	spore germination
SH83_RS14435	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
SH83_RS14460	COG0477	Major facilitator Superfamily
SH83_RS14520	COG0737	Belongs to the 5'-nucleotidase family
SH83_RS14530	COG0656	L-ascorbic acid biosynthetic process
SH83_RS14550	COG1968	undecaprenyl-diphosphatase activity
SH83_RS14555	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SH83_RS14590	COG2207	Transcriptional regulator
SH83_RS14620	COG0076	glutamate decarboxylase activity
SH83_RS14690	COG2226	methyltransferase
SH83_RS14710	COG2217	Heavy metal translocating P-type atpase
SH83_RS14715	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SH83_RS14720	COG3118	belongs to the thioredoxin family
SH83_RS14725	COG1937	Protein conserved in bacteria
SH83_RS14745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SH83_RS14750	COG3590	peptidase
SH83_RS14775	COG0446	pyridine nucleotide-disulphide oxidoreductase
SH83_RS14825	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SH83_RS14835	COG1114	Component of the transport system for branched-chain amino acids
SH83_RS14845	COG1874	Beta-galactosidase
SH83_RS14850	COG1609	Transcriptional regulator
SH83_RS14860	COG0477	Major facilitator Superfamily
SH83_RS14880	COG2184	nucleotidyltransferase activity
SH83_RS14885	COG2944	sequence-specific DNA binding
SH83_RS14890	COG1609	Transcriptional regulator
SH83_RS14895	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SH83_RS14900	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SH83_RS14905	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SH83_RS14925	COG2211	Major facilitator Superfamily
SH83_RS14925	COG2190	(PTS) system
SH83_RS14930	COG2017	converts alpha-aldose to the beta-anomer
SH83_RS14935	COG1609	Transcriptional regulator
SH83_RS14940	COG0667	Aldo Keto reductase
SH83_RS14960	COG0710	3-dehydroquinate dehydratase activity
SH83_RS14965	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SH83_RS14970	COG0583	DNA-binding transcription factor activity
SH83_RS14975	COG2271	Major facilitator Superfamily
SH83_RS14990	COG1028	Short-chain dehydrogenase reductase Sdr
SH83_RS15005	COG2271	Major facilitator Superfamily
SH83_RS15015	COG2267	carboxylic ester hydrolase activity
SH83_RS15020	COG2188	Transcriptional regulator
SH83_RS15025	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SH83_RS15030	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SH83_RS15035	COG2971	BadF BadG BcrA BcrD
SH83_RS15045	COG2723	6-phospho-beta-galactosidase activity
SH83_RS15055	COG3711	transcriptional antiterminator
SH83_RS15065	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SH83_RS15070	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SH83_RS15070	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SH83_RS15075	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SH83_RS15075	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SH83_RS15075	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SH83_RS15080	COG2190	(PTS) system
SH83_RS15080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SH83_RS15080	COG1263	PTS System
SH83_RS15085	COG1737	Transcriptional regulator
SH83_RS15090	COG1263	PTS System
SH83_RS15090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SH83_RS15095	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SH83_RS15105	COG2723	6-phospho-beta-galactosidase activity
SH83_RS15110	COG2723	6-phospho-beta-galactosidase activity
SH83_RS15115	COG2190	(PTS) system
SH83_RS15115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SH83_RS15115	COG1263	PTS System
SH83_RS15135	COG2211	Major facilitator Superfamily
SH83_RS15150	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
SH83_RS15165	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SH83_RS15185	COG3711	transcriptional antiterminator
SH83_RS15200	COG3775	system Galactitol-specific IIC component
SH83_RS15205	COG3414	Phosphotransferase system galactitol-specific IIB component
SH83_RS15215	COG1349	DNA-binding transcription factor activity
SH83_RS15220	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SH83_RS15230	COG0110	maltose O-acetyltransferase activity
SH83_RS15235	COG2160	L-arabinose isomerase activity
SH83_RS15255	COG1609	Transcriptional regulator
SH83_RS15260	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SH83_RS15290	COG2261	transglycosylase associated protein
SH83_RS15300	COG1393	Belongs to the ArsC family
SH83_RS15320	COG4512	PFAM Accessory gene regulator B
SH83_RS15335	COG1304	FMN binding
SH83_RS15340	COG0028	Belongs to the TPP enzyme family
SH83_RS15345	COG1959	2 iron, 2 sulfur cluster binding
SH83_RS15350	COG0028	Belongs to the TPP enzyme family
SH83_RS15365	COG0235	Class ii aldolase
SH83_RS15370	COG4806	L-rhamnose isomerase
SH83_RS15375	COG3254	rhamnose metabolic process
SH83_RS15380	COG1070	Carbohydrate kinase
SH83_RS15385	COG2814	Major facilitator Superfamily
SH83_RS15395	COG2826	transposase and inactivated derivatives, IS30 family
SH83_RS15405	COG1349	DNA-binding transcription factor activity
SH83_RS15420	COG3775	system Galactitol-specific IIC component
SH83_RS15435	COG2814	Major facilitator Superfamily
SH83_RS15440	COG0673	inositol 2-dehydrogenase activity
SH83_RS15445	COG0673	inositol 2-dehydrogenase activity
SH83_RS15450	COG1082	Xylose isomerase domain protein TIM barrel
SH83_RS15455	COG0673	inositol 2-dehydrogenase activity
SH83_RS15460	COG2814	Major facilitator Superfamily
SH83_RS15465	COG0673	inositol 2-dehydrogenase activity
SH83_RS15470	COG4702	Belongs to the UPF0303 family
SH83_RS15475	COG0604	alcohol dehydrogenase
SH83_RS15480	COG1957	nucleoside hydrolase
SH83_RS15495	COG3732	PTS system glucitol sorbitol-specific
SH83_RS15500	COG3730	PTS system glucitol sorbitol-specific
SH83_RS15510	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SH83_RS15510	COG3711	transcriptional antiterminator
SH83_RS15525	COG1609	Transcriptional regulator
SH83_RS15535	COG0366	Alpha amylase catalytic
SH83_RS15545	COG2723	6-phospho-beta-galactosidase activity
SH83_RS15550	COG1940	carbohydrate kinase activity
SH83_RS15555	COG0383	alpha-mannosidase activity
SH83_RS15565	COG2188	Transcriptional regulator
SH83_RS15575	COG3842	ATPase activity
SH83_RS15585	COG2207	Transcriptional regulator
SH83_RS15585	COG4753	response regulator
SH83_RS15590	COG2972	Histidine kinase
SH83_RS15600	COG0366	Alpha amylase catalytic
SH83_RS15605	COG1653	transport
SH83_RS15610	COG0395	ABC-type sugar transport system, permease component
SH83_RS15625	COG2207	Transcriptional regulator
SH83_RS15625	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SH83_RS15630	COG1132	(ABC) transporter
SH83_RS15635	COG1132	(ABC) transporter
SH83_RS15640	COG2188	Transcriptional regulator
SH83_RS15655	COG3732	PTS system glucitol sorbitol-specific
SH83_RS15660	COG3730	PTS system glucitol sorbitol-specific
SH83_RS15680	COG4975	Glucose uptake
SH83_RS15685	COG1869	D-ribose catabolic process
SH83_RS15695	COG1609	Transcriptional regulator
SH83_RS15700	COG1012	belongs to the aldehyde dehydrogenase family
SH83_RS15700	COG1454	alcohol dehydrogenase
SH83_RS15710	COG1695	Transcriptional regulator
SH83_RS15715	COG3479	Phenolic acid decarboxylase
SH83_RS15730	COG1307	EDD domain protein, DegV family
SH83_RS15770	COG0445	tRNA wobble uridine modification
SH83_RS15775	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SH83_RS15780	COG1847	R3H domain protein
SH83_RS15790	COG4166	transmembrane transport
SH83_RS15795	COG0706	membrane insertase activity
SH83_RS15800	COG0594	ribonuclease P activity
SH83_RS15805	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SH83_RS15850	COG0791	NLP P60 protein
SH83_RS15850	COG0741	lytic transglycosylase activity
SH83_RS15855	COG5644	endopeptidase inhibitor activity
SH83_RS15865	COG0433	COG0433 Predicted ATPase