locus-tag	class	description
CLC99_RS00005	COG0028	Belongs to the TPP enzyme family
CLC99_RS00010	COG0196	riboflavin kinase activity
CLC99_RS00015	COG0028	Belongs to the TPP enzyme family
CLC99_RS00020	COG2267	carboxylic ester hydrolase activity
CLC99_RS00030	COG2755	lipolytic protein G-D-S-L family
CLC99_RS00030	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CLC99_RS00035	COG2936	dipeptidyl-peptidase activity
CLC99_RS00050	COG0531	amino acid
CLC99_RS00075	COG0194	GDP metabolic process
CLC99_RS00080	COG0735	belongs to the Fur family
CLC99_RS00095	COG0546	phosphoglycolate phosphatase activity
CLC99_RS00100	COG0436	Aminotransferase
CLC99_RS00105	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CLC99_RS00125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLC99_RS00130	COG0765	amino acid transport
CLC99_RS00135	COG0765	amino acid transport
CLC99_RS00140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLC99_RS00140	COG1263	PTS System
CLC99_RS00140	COG2190	(PTS) system
CLC99_RS00150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLC99_RS00150	COG1263	PTS System
CLC99_RS00155	COG3394	polysaccharide catabolic process
CLC99_RS00160	COG0531	amino acid
CLC99_RS00170	COG1846	Transcriptional regulator
CLC99_RS00200	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CLC99_RS00210	COG2076	Multidrug Resistance protein
CLC99_RS00225	COG0588	phosphoglycerate mutase activity
CLC99_RS00230	COG0569	domain protein
CLC99_RS00230	COG0475	glutathione-regulated potassium exporter activity
CLC99_RS00235	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CLC99_RS00235	COG0456	acetyltransferase
CLC99_RS00240	COG0586	Pfam SNARE associated Golgi protein
CLC99_RS00245	COG3973	AAA domain
CLC99_RS00250	COG2070	2-Nitropropane dioxygenase
CLC99_RS00255	COG1072	(Pantothenic acid kinase))
CLC99_RS00260	COG0519	Catalyzes the synthesis of GMP from XMP
CLC99_RS00260	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CLC99_RS00265	COG0464	growth
CLC99_RS00310	COG1396	sequence-specific DNA binding
CLC99_RS00315	COG1266	CAAX protease self-immunity
CLC99_RS00320	COG1733	regulation of RNA biosynthetic process
CLC99_RS00325	COG2814	Major facilitator Superfamily
CLC99_RS00340	COG2755	lipolytic protein G-D-S-L family
CLC99_RS00340	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CLC99_RS00345	COG2261	transglycosylase associated protein
CLC99_RS00360	COG1302	Protein conserved in bacteria
CLC99_RS00390	COG0308	aminopeptidase N
CLC99_RS00420	COG0572	uridine kinase
CLC99_RS00435	COG0583	DNA-binding transcription factor activity
CLC99_RS00440	COG1053	succinate dehydrogenase
CLC99_RS00450	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CLC99_RS00455	COG0017	Asparaginyl-tRNA synthetase
CLC99_RS00460	COG2502	aspartate--ammonia ligase
CLC99_RS00465	COG4690	dipeptidase activity
CLC99_RS00485	COG0514	ATP-dependent DNA helicase (RecQ)
CLC99_RS00490	COG0564	pseudouridine synthase activity
CLC99_RS00495	COG0640	Transcriptional regulator
CLC99_RS00545	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CLC99_RS00550	COG0527	aspartate kinase activity
CLC99_RS00555	COG0367	asparagine synthase
CLC99_RS00625	COG1278	Cold shock
CLC99_RS00630	COG2966	Psort location CytoplasmicMembrane, score
CLC99_RS00640	COG1316	TRANSCRIPTIONal
CLC99_RS00660	COG1959	2 iron, 2 sulfur cluster binding
CLC99_RS00665	COG0028	Belongs to the TPP enzyme family
CLC99_RS00670	COG0833	amino acid
CLC99_RS00680	COG1428	Deoxynucleoside kinase
CLC99_RS00685	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CLC99_RS00725	COG4463	regulation of RNA biosynthetic process
CLC99_RS00730	COG0542	response to heat
CLC99_RS00740	COG0085	RNA polymerase activity
CLC99_RS00745	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CLC99_RS00750	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CLC99_RS00755	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CLC99_RS00760	COG0049	tRNA binding
CLC99_RS00765	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CLC99_RS00770	COG0051	transcription antitermination factor activity, RNA binding
CLC99_RS00775	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CLC99_RS00780	COG0088	Forms part of the polypeptide exit tunnel
CLC99_RS00785	COG0089	rRNA binding
CLC99_RS00790	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CLC99_RS00795	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CLC99_RS00800	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CLC99_RS00805	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CLC99_RS00810	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CLC99_RS00815	COG0255	Belongs to the universal ribosomal protein uL29 family
CLC99_RS00820	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CLC99_RS00825	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CLC99_RS00830	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CLC99_RS00835	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CLC99_RS00840	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CLC99_RS00845	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CLC99_RS00850	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CLC99_RS00855	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CLC99_RS00860	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CLC99_RS00865	COG1841	ribosomal large subunit assembly
CLC99_RS00870	COG0200	Binds to the 23S rRNA
CLC99_RS00880	COG0563	adenylate kinase activity
CLC99_RS00885	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CLC99_RS00890	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CLC99_RS00895	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CLC99_RS00900	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CLC99_RS00905	COG0202	RNA polymerase activity
CLC99_RS00910	COG0203	ribosomal protein L17
CLC99_RS00935	COG4939	FMN-binding domain protein
CLC99_RS00945	COG1122	ATPase activity
CLC99_RS00950	COG1122	ATPase activity
CLC99_RS00960	COG0101	tRNA pseudouridine synthase activity
CLC99_RS00965	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CLC99_RS00970	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CLC99_RS00975	COG4974	Belongs to the 'phage' integrase family
CLC99_RS01075	COG0270	DNA (cytosine-5-)-methyltransferase activity
CLC99_RS01135	COG5484	DNA packaging
CLC99_RS01140	COG1783	phage Terminase large subunit
CLC99_RS01280	COG1136	(ABC) transporter
CLC99_RS01280	COG0577	efflux transmembrane transporter activity
CLC99_RS01290	COG1132	(ABC) transporter
CLC99_RS01340	COG4886	Leucine-rich repeat (LRR) protein
CLC99_RS01340	COG4932	domain protein
CLC99_RS01410	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CLC99_RS01420	COG1970	mechanosensitive ion channel activity
CLC99_RS01555	COG5484	DNA packaging
CLC99_RS01555	COG3728	DNA packaging
CLC99_RS01570	COG2868	ribosomal protein
CLC99_RS01700	COG0726	polysaccharide deacetylase
CLC99_RS01715	COG1132	(ABC) transporter
CLC99_RS01735	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CLC99_RS01745	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CLC99_RS01750	COG1482	cell wall glycoprotein biosynthetic process
CLC99_RS01755	COG3442	glutamine amidotransferase
CLC99_RS01760	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CLC99_RS01765	COG1435	thymidine kinase activity
CLC99_RS01770	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CLC99_RS01775	COG2890	protein-(glutamine-N5) methyltransferase activity
CLC99_RS01780	COG0009	L-threonylcarbamoyladenylate synthase
CLC99_RS01785	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CLC99_RS01790	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CLC99_RS01800	COG2233	PERMEase
CLC99_RS01805	COG0356	it plays a direct role in the translocation of protons across the membrane
CLC99_RS01810	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CLC99_RS01815	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CLC99_RS01820	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CLC99_RS01825	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CLC99_RS01830	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CLC99_RS01835	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CLC99_RS01840	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CLC99_RS01845	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CLC99_RS01855	COG1077	Cell shape determining protein MreB Mrl
CLC99_RS01860	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CLC99_RS01870	COG0772	Belongs to the SEDS family
CLC99_RS01875	COG0509	glycine decarboxylation via glycine cleavage system
CLC99_RS01880	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CLC99_RS01885	COG2011	ABC-type metal ion transport system permease component
CLC99_RS01890	COG1464	Belongs to the NlpA lipoprotein family
CLC99_RS01910	COG1181	Belongs to the D-alanine--D-alanine ligase family
CLC99_RS01930	COG0589	response to stress
CLC99_RS01945	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CLC99_RS01950	COG2918	glutathione biosynthetic process
CLC99_RS01950	COG0189	ligase activity
CLC99_RS01955	COG1609	Transcriptional regulator
CLC99_RS01960	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLC99_RS01965	COG3715	PTS system
CLC99_RS01970	COG3716	PTS system mannose fructose sorbose family IID component
CLC99_RS01980	COG0366	Alpha amylase catalytic
CLC99_RS01985	COG0640	Transcriptional regulator
CLC99_RS02000	COG4493	Belongs to the UPF0637 family
CLC99_RS02005	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CLC99_RS02010	COG1956	GAF domain-containing protein
CLC99_RS02015	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CLC99_RS02025	COG1104	cysteine desulfurase activity
CLC99_RS02030	COG0301	tRNA thio-modification
CLC99_RS02040	COG1181	Belongs to the D-alanine--D-alanine ligase family
CLC99_RS02040	COG2918	glutathione biosynthetic process
CLC99_RS02050	COG0525	valine-tRNA ligase activity
CLC99_RS02055	COG0285	dihydrofolate synthase activity
CLC99_RS02060	COG2003	Belongs to the UPF0758 family
CLC99_RS02065	COG1077	Cell shape determining protein MreB Mrl
CLC99_RS02070	COG1792	Involved in formation and maintenance of cell shape
CLC99_RS02080	COG0850	regulation of cytokinetic process
CLC99_RS02085	COG2894	cell division
CLC99_RS02090	COG0765	amino acid transport
CLC99_RS02095	COG1126	abc transporter atp-binding protein
CLC99_RS02100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLC99_RS02110	COG0527	aspartate kinase activity
CLC99_RS02115	COG0612	Peptidase, M16
CLC99_RS02120	COG0612	Peptidase, M16
CLC99_RS02125	COG1426	Protein conserved in bacteria
CLC99_RS02130	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CLC99_RS02135	COG1546	Belongs to the CinA family
CLC99_RS02135	COG1058	Belongs to the CinA family
CLC99_RS02140	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CLC99_RS02145	COG1418	mRNA catabolic process
CLC99_RS02150	COG1692	metallophosphoesterase
CLC99_RS02155	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CLC99_RS02160	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CLC99_RS02190	COG0632	four-way junction helicase activity
CLC99_RS02195	COG2255	four-way junction helicase activity
CLC99_RS02200	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CLC99_RS02205	COG0343	queuine tRNA-ribosyltransferase activity
CLC99_RS02210	COG1862	Preprotein translocase
CLC99_RS02215	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CLC99_RS02220	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CLC99_RS02225	COG0513	Belongs to the DEAD box helicase family
CLC99_RS02230	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CLC99_RS02235	COG4472	Bacterial protein of unknown function (DUF965)
CLC99_RS02240	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CLC99_RS02245	COG3906	Belongs to the UPF0473 family
CLC99_RS02255	COG1193	negative regulation of DNA recombination
CLC99_RS02260	COG3118	belongs to the thioredoxin family
CLC99_RS02265	COG1719	4-vinyl reductase, 4VR
CLC99_RS02270	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CLC99_RS02275	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CLC99_RS02285	COG0517	IMP dehydrogenase activity
CLC99_RS02290	COG2171	N-acyltransferase activity
CLC99_RS02295	COG1473	amidohydrolase
CLC99_RS02300	COG0668	transmembrane transport
CLC99_RS02315	COG0789	Transcriptional regulator
CLC99_RS02320	COG0006	proline dipeptidase activity
CLC99_RS02325	COG1609	Transcriptional regulator
CLC99_RS02340	COG0217	transcriptional regulatory protein
CLC99_RS02350	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CLC99_RS02380	COG0827	DNA restriction-modification system
CLC99_RS02385	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CLC99_RS02390	COG1113	amino acid transport
CLC99_RS02405	COG0737	Belongs to the 5'-nucleotidase family
CLC99_RS02410	COG4470	Protein conserved in bacteria
CLC99_RS02415	COG0647	UMP catabolic process
CLC99_RS02425	COG0586	Pfam SNARE associated Golgi protein
CLC99_RS02435	COG1098	S1 RNA binding domain
CLC99_RS02580	COG1234	tRNA 3'-trailer cleavage
CLC99_RS02590	COG4862	establishment of competence for transformation
CLC99_RS02600	COG1164	Oligoendopeptidase f
CLC99_RS02610	COG2357	RelA SpoT domain protein
CLC99_RS02615	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CLC99_RS02620	COG0564	pseudouridine synthase activity
CLC99_RS02625	COG3142	Participates in the control of copper homeostasis
CLC99_RS02630	COG2706	6-phosphogluconolactonase activity
CLC99_RS02640	COG0628	permease
CLC99_RS02645	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CLC99_RS02660	COG1114	Component of the transport system for branched-chain amino acids
CLC99_RS02670	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CLC99_RS02675	COG1674	ftsk spoiiie
CLC99_RS02695	COG2001	Belongs to the MraZ family
CLC99_RS02700	COG0275	rRNA processing
CLC99_RS02710	COG0768	penicillin binding
CLC99_RS02715	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CLC99_RS02720	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CLC99_RS02725	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CLC99_RS02730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CLC99_RS02745	COG1799	cell septum assembly
CLC99_RS02750	COG0762	integral membrane protein
CLC99_RS02760	COG3599	regulation of cell shape
CLC99_RS02765	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CLC99_RS02780	COG3279	Response regulator of the LytR AlgR family
CLC99_RS02790	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CLC99_RS02795	COG0494	nUDIX hydrolase
CLC99_RS02805	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CLC99_RS02810	COG1104	cysteine desulfurase activity
CLC99_RS02820	COG0482	sulfurtransferase activity
CLC99_RS02825	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CLC99_RS02830	COG0569	domain protein
CLC99_RS02865	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CLC99_RS02870	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CLC99_RS02875	COG3584	3D domain protein
CLC99_RS02875	COG1388	LysM domain
CLC99_RS02885	COG1597	lipid kinase activity
CLC99_RS02890	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CLC99_RS02895	COG5503	Protein of unknown function (DUF1447)
CLC99_RS02905	COG0242	peptide deformylase activity
CLC99_RS02930	COG0039	L-malate dehydrogenase activity
CLC99_RS02935	COG4476	Belongs to the UPF0223 family
CLC99_RS02940	COG0483	inositol monophosphate 1-phosphatase activity
CLC99_RS02945	COG1217	gtp-binding protein TYPA
CLC99_RS02980	COG0772	Belongs to the SEDS family
CLC99_RS02985	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CLC99_RS02990	COG4471	UPF0298 protein
CLC99_RS02995	COG0742	ribosomal rna small subunit methyltransferase
CLC99_RS03000	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CLC99_RS03005	COG3480	Lon protease (S16) C-terminal proteolytic domain
CLC99_RS03010	COG1555	photosystem II stabilization
CLC99_RS03010	COG1596	polysaccharide export
CLC99_RS03015	COG2131	deaminase
CLC99_RS03020	COG0658	competence protein
CLC99_RS03020	COG2333	competence protein COMEC
CLC99_RS03025	COG1466	dna polymerase III delta subunit
CLC99_RS03030	COG0268	Binds directly to 16S ribosomal RNA
CLC99_RS03035	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CLC99_RS03060	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CLC99_RS03065	COG0544	peptidyl-prolyl cis-trans isomerase activity
CLC99_RS03070	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CLC99_RS03075	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CLC99_RS03095	COG0765	amino acid transport
CLC99_RS03100	COG1126	abc transporter atp-binding protein
CLC99_RS03105	COG0322	excinuclease ABC activity
CLC99_RS03115	COG0489	protein tyrosine kinase activity
CLC99_RS03125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CLC99_RS03130	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CLC99_RS03135	COG0438	transferase activity, transferring glycosyl groups
CLC99_RS03165	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CLC99_RS03165	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLC99_RS03165	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CLC99_RS03170	COG1105	Belongs to the carbohydrate kinase PfkB family
CLC99_RS03175	COG1349	DNA-binding transcription factor activity
CLC99_RS03180	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CLC99_RS03190	COG1234	tRNA 3'-trailer cleavage
CLC99_RS03195	COG0300	oxidoreductase activity
CLC99_RS03200	COG5416	Lipopolysaccharide assembly protein A domain
CLC99_RS03205	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CLC99_RS03205	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CLC99_RS03210	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CLC99_RS03225	COG0393	Putative heavy-metal-binding
CLC99_RS03260	COG0772	Belongs to the SEDS family
CLC99_RS03270	COG1116	anion transmembrane transporter activity
CLC99_RS03285	COG0463	Glycosyl transferase, family 2
CLC99_RS03300	COG3425	synthase
CLC99_RS03315	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CLC99_RS03320	COG4224	UPF0291 protein
CLC99_RS03325	COG3763	UPF0154 protein
CLC99_RS03330	COG0204	Acyl-transferase
CLC99_RS03335	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CLC99_RS03340	COG2827	Endonuclease containing a URI domain
CLC99_RS03345	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CLC99_RS03355	COG0052	Belongs to the universal ribosomal protein uS2 family
CLC99_RS03360	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CLC99_RS03365	COG0528	UMP kinase activity
CLC99_RS03370	COG0233	cytoplasmic translational termination
CLC99_RS03375	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CLC99_RS03380	COG4589	Belongs to the CDS family
CLC99_RS03385	COG0750	zinc metalloprotease
CLC99_RS03390	COG0442	prolyl-tRNA aminoacylation
CLC99_RS03395	COG2176	DNA-directed DNA polymerase activity
CLC99_RS03400	COG0779	Required for maturation of 30S ribosomal subunits
CLC99_RS03405	COG0195	Participates in both transcription termination and antitermination
CLC99_RS03410	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CLC99_RS03420	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CLC99_RS03425	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CLC99_RS03430	COG0738	Major facilitator superfamily
CLC99_RS03435	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CLC99_RS03445	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CLC99_RS03450	COG0287	Prephenate dehydrogenase
CLC99_RS03455	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CLC99_RS03460	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CLC99_RS03465	COG0196	riboflavin kinase activity
CLC99_RS03470	COG3527	Alpha-acetolactate decarboxylase
CLC99_RS03475	COG1420	regulation of RNA biosynthetic process
CLC99_RS03480	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CLC99_RS03485	COG0443	Heat shock 70 kDa protein
CLC99_RS03490	COG0484	heat shock protein binding
CLC99_RS03495	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CLC99_RS03505	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CLC99_RS03510	COG1696	Membrane protein involved in D-alanine export
CLC99_RS03515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CLC99_RS03520	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CLC99_RS03525	COG0481	GTPase activity
CLC99_RS03540	COG2094	Belongs to the DNA glycosylase MPG family
CLC99_RS03545	COG2264	protein methyltransferase activity
CLC99_RS03550	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CLC99_RS03560	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CLC99_RS03565	COG1490	D-aminoacyl-tRNA deacylase activity
CLC99_RS03570	COG0546	phosphoglycolate phosphatase activity
CLC99_RS03575	COG3001	Fructosamine kinase
CLC99_RS03580	COG0860	N-Acetylmuramoyl-L-alanine amidase
CLC99_RS03580	COG3103	Sh3 type 3 domain protein
CLC99_RS03580	COG4991	sh3 domain protein
CLC99_RS03585	COG0124	histidyl-tRNA synthetase
CLC99_RS03590	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CLC99_RS03600	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CLC99_RS03610	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CLC99_RS03620	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CLC99_RS03625	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CLC99_RS03630	COG1610	YqeY-like protein
CLC99_RS03635	COG1702	phosphate starvation-inducible protein PhoH
CLC99_RS03640	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CLC99_RS03645	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CLC99_RS03650	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CLC99_RS03655	COG1381	Involved in DNA repair and RecF pathway recombination
CLC99_RS03660	COG0752	glycyl-tRNA synthetase alpha subunit
CLC99_RS03665	COG0751	glycine-tRNA ligase activity
CLC99_RS03670	COG0358	DNA primase activity
CLC99_RS03675	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CLC99_RS03685	COG1725	Transcriptional regulator
CLC99_RS03690	COG1131	(ABC) transporter
CLC99_RS03710	COG1131	(ABC) transporter
CLC99_RS03725	COG0519	Catalyzes the synthesis of GMP from XMP
CLC99_RS03735	COG1131	(ABC) transporter
CLC99_RS03745	COG4585	Histidine kinase
CLC99_RS03750	COG2197	response regulator
CLC99_RS03755	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLC99_RS03765	COG0604	alcohol dehydrogenase
CLC99_RS03770	COG0583	DNA-binding transcription factor activity
CLC99_RS03800	COG0546	phosphoglycolate phosphatase activity
CLC99_RS03820	COG1393	Belongs to the ArsC family
CLC99_RS03830	COG1349	DNA-binding transcription factor activity
CLC99_RS03835	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLC99_RS03840	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CLC99_RS03850	COG0477	Major facilitator Superfamily
CLC99_RS03855	COG0148	phosphopyruvate hydratase activity
CLC99_RS03860	COG2217	Heavy metal translocating P-type atpase
CLC99_RS03880	COG1846	Transcriptional regulator
CLC99_RS03890	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CLC99_RS03890	COG0574	Belongs to the PEP-utilizing enzyme family
CLC99_RS03915	COG2384	SAM-dependent methyltransferase
CLC99_RS03920	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CLC99_RS03930	COG0542	response to heat
CLC99_RS03940	COG0587	DNA-directed DNA polymerase activity
CLC99_RS03945	COG0205	6-phosphofructokinase activity
CLC99_RS03965	COG2996	Protein conserved in bacteria
CLC99_RS03970	COG4974	Belongs to the 'phage' integrase family
CLC99_RS03980	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CLC99_RS03985	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CLC99_RS03990	COG1187	pseudouridine synthase activity
CLC99_RS03995	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CLC99_RS04005	COG0514	ATP-dependent DNA helicase (RecQ)
CLC99_RS04015	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CLC99_RS04020	COG0539	negative regulation of cytoplasmic translation
CLC99_RS04025	COG1160	GTP binding
CLC99_RS04040	COG0457	Tetratricopeptide repeat
CLC99_RS04045	COG0561	phosphatase activity
CLC99_RS04050	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CLC99_RS04055	COG0617	tRNA 3'-terminal CCA addition
CLC99_RS04070	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CLC99_RS04075	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CLC99_RS04080	COG1307	EDD domain protein, DegV family
CLC99_RS04085	COG2755	lipolytic protein G-D-S-L family
CLC99_RS04090	COG4698	Protein conserved in bacteria
CLC99_RS04095	COG4479	Belongs to the UPF0346 family
CLC99_RS04100	COG0793	Belongs to the peptidase S41A family
CLC99_RS04100	COG3409	Peptidoglycan-binding domain 1 protein
CLC99_RS04110	COG2814	Major facilitator Superfamily
CLC99_RS04125	COG0583	DNA-binding transcription factor activity
CLC99_RS04130	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CLC99_RS04145	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CLC99_RS04150	COG0758	DNA mediated transformation
CLC99_RS04155	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CLC99_RS04160	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CLC99_RS04165	COG4974	Belongs to the 'phage' integrase family
CLC99_RS04170	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CLC99_RS04175	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CLC99_RS04185	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CLC99_RS04190	COG0187	DNA topoisomerase II activity
CLC99_RS04200	COG0583	DNA-binding transcription factor activity
CLC99_RS04205	COG1227	inorganic diphosphatase activity
CLC99_RS04210	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CLC99_RS04245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CLC99_RS04250	COG1846	Transcriptional regulator
CLC99_RS04275	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CLC99_RS04285	COG1620	l-lactate permease
CLC99_RS04305	COG1113	amino acid transport
CLC99_RS04365	COG1307	EDD domain protein, DegV family
CLC99_RS04375	COG1293	RNA-binding protein homologous to eukaryotic snRNP
CLC99_RS04385	COG1131	(ABC) transporter
CLC99_RS04410	COG5646	InterPro IPR014922
CLC99_RS04425	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CLC99_RS04430	COG0505	Belongs to the CarA family
CLC99_RS04435	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CLC99_RS04440	COG0564	pseudouridine synthase activity
CLC99_RS04445	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CLC99_RS04450	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CLC99_RS04465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLC99_RS04490	COG1619	proteins homologs of microcin C7 resistance protein MccF
CLC99_RS04510	COG1216	Glycosyl transferase, family 2
CLC99_RS04520	COG1073	alpha beta
CLC99_RS04525	COG0116	Belongs to the methyltransferase superfamily
CLC99_RS04535	COG3599	regulation of cell shape
CLC99_RS04540	COG4474	Belongs to the UPF0398 family
CLC99_RS04560	COG1840	ABC-type Fe3 transport system, periplasmic component
CLC99_RS04565	COG1177	transmembrane transport
CLC99_RS04575	COG1464	Belongs to the NlpA lipoprotein family
CLC99_RS04580	COG2011	ABC-type metal ion transport system permease component
CLC99_RS04585	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CLC99_RS04600	COG0017	Asparaginyl-tRNA synthetase
CLC99_RS04615	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CLC99_RS04615	COG1199	ATP-dependent helicase activity
CLC99_RS04640	COG1304	FMN binding
CLC99_RS04645	COG2017	converts alpha-aldose to the beta-anomer
CLC99_RS04665	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CLC99_RS04665	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CLC99_RS04670	COG0561	phosphatase activity
CLC99_RS04675	COG0531	amino acid
CLC99_RS04715	COG1942	4-Oxalocrotonate Tautomerase
CLC99_RS04730	COG3237	CsbD-like
CLC99_RS04735	COG2261	transglycosylase associated protein
CLC99_RS04750	COG1597	lipid kinase activity
CLC99_RS04755	COG3152	Membrane
CLC99_RS04765	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
CLC99_RS04780	COG3397	chitin binding
CLC99_RS04785	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CLC99_RS04835	COG0477	Major facilitator Superfamily
CLC99_RS04845	COG1162	GTPase activity
CLC99_RS04850	COG1607	acyl-coa hydrolase
CLC99_RS04855	COG0583	DNA-binding transcription factor activity
CLC99_RS04860	COG1811	Na channel or pump
CLC99_RS04870	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CLC99_RS04885	COG0439	Biotin carboxylase
CLC99_RS04900	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CLC99_RS04905	COG1028	Short-chain dehydrogenase reductase Sdr
CLC99_RS04910	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CLC99_RS04915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CLC99_RS04920	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLC99_RS04925	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CLC99_RS04935	COG0300	oxidoreductase activity
CLC99_RS04945	COG1063	alcohol dehydrogenase
CLC99_RS04950	COG1473	amidohydrolase
CLC99_RS04960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CLC99_RS04980	COG0133	tryptophan synthase activity
CLC99_RS04985	COG0135	phosphoribosylanthranilate isomerase activity
CLC99_RS04990	COG0134	indole-3-glycerol-phosphate synthase activity
CLC99_RS04995	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CLC99_RS05000	COG0512	Glutamine amidotransferase of anthranilate synthase
CLC99_RS05000	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CLC99_RS05015	COG1131	(ABC) transporter
CLC99_RS05035	COG0335	large ribosomal subunit rRNA binding
CLC99_RS05040	COG0336	Belongs to the RNA methyltransferase TrmD family
CLC99_RS05045	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CLC99_RS05050	COG1837	Belongs to the UPF0109 family
CLC99_RS05055	COG0228	four-way junction DNA binding
CLC99_RS05060	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CLC99_RS05065	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CLC99_RS05070	COG0552	protein localization to endoplasmic reticulum
CLC99_RS05075	COG1196	nuclear chromosome segregation
CLC99_RS05080	COG0571	ribonuclease III activity
CLC99_RS05085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CLC99_RS05090	COG0416	fatty acid biosynthetic process
CLC99_RS05095	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CLC99_RS05100	COG1461	Dihydroxyacetone kinase
CLC99_RS05105	COG1302	Protein conserved in bacteria
CLC99_RS05110	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CLC99_RS05115	COG1564	THIamine pyrophosphokinase
CLC99_RS05120	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CLC99_RS05125	COG1162	GTPase activity
CLC99_RS05130	COG0515	serine threonine protein kinase
CLC99_RS05130	COG2815	serine threonine protein kinase
CLC99_RS05135	COG0631	protein serine/threonine phosphatase activity
CLC99_RS05140	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CLC99_RS05140	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CLC99_RS05145	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CLC99_RS05150	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CLC99_RS05155	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CLC99_RS05160	COG1758	RNA polymerase activity
CLC99_RS05165	COG0194	GDP metabolic process
CLC99_RS05180	COG1732	Glycine betaine
CLC99_RS05195	COG0497	DNA recombination
CLC99_RS05200	COG1438	arginine binding
CLC99_RS05205	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CLC99_RS05210	COG0142	geranyltranstransferase activity
CLC99_RS05215	COG1722	exodeoxyribonuclease VII activity
CLC99_RS05220	COG1570	exodeoxyribonuclease VII activity
CLC99_RS05225	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CLC99_RS05230	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CLC99_RS05235	COG1302	Protein conserved in bacteria
CLC99_RS05240	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CLC99_RS05245	COG0006	proline dipeptidase activity
CLC99_RS05250	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CLC99_RS05260	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CLC99_RS05310	COG0789	Transcriptional regulator
CLC99_RS05315	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CLC99_RS05320	COG0584	glycerophosphoryl diester phosphodiesterase
CLC99_RS05340	COG1940	carbohydrate kinase activity
CLC99_RS05350	COG0705	Rhomboid family
CLC99_RS05350	COG0457	Tetratricopeptide repeat
CLC99_RS05355	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CLC99_RS05360	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CLC99_RS05365	COG0768	penicillin binding
CLC99_RS05375	COG4841	protein insertion into membrane
CLC99_RS05400	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CLC99_RS05405	COG0572	uridine kinase
CLC99_RS05410	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CLC99_RS05415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLC99_RS05415	COG0072	phenylalanine-tRNA ligase activity
CLC99_RS05420	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CLC99_RS05425	COG1733	regulation of RNA biosynthetic process
CLC99_RS05435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CLC99_RS05440	COG1254	Belongs to the acylphosphatase family
CLC99_RS05445	COG0706	membrane insertase activity
CLC99_RS05460	COG0419	ATPase involved in DNA repair
CLC99_RS05470	COG5002	protein histidine kinase activity
CLC99_RS05475	COG0745	RESPONSE REGULATOR receiver
CLC99_RS05480	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CLC99_RS05485	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CLC99_RS05500	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CLC99_RS05510	COG1323	Belongs to the UPF0348 family
CLC99_RS05515	COG2226	methyltransferase
CLC99_RS05520	COG0799	negative regulation of ribosome biogenesis
CLC99_RS05525	COG1713	HD superfamily hydrolase involved in NAD metabolism
CLC99_RS05530	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CLC99_RS05535	COG1534	Rna-binding protein
CLC99_RS05540	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CLC99_RS05555	COG1215	transferase activity, transferring glycosyl groups
CLC99_RS05565	COG1733	regulation of RNA biosynthetic process
CLC99_RS05570	COG0604	alcohol dehydrogenase
CLC99_RS05575	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CLC99_RS05585	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CLC99_RS05590	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CLC99_RS05595	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CLC99_RS05600	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CLC99_RS05605	COG1484	DNA-dependent DNA replication
CLC99_RS05610	COG3611	Membrane attachment protein
CLC99_RS05615	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CLC99_RS05620	COG0237	dephospho-CoA kinase activity
CLC99_RS05625	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CLC99_RS05630	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CLC99_RS05630	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CLC99_RS05645	COG2151	metal-sulfur cluster biosynthetic enzyme
CLC99_RS05650	COG0719	Fe-S assembly protein
CLC99_RS05660	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CLC99_RS05665	COG0719	Fe-S assembly protein
CLC99_RS05690	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CLC99_RS05695	COG1674	ftsk spoiiie
CLC99_RS05700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLC99_RS05710	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CLC99_RS05715	COG0510	thiamine kinase activity
CLC99_RS05720	COG4473	ABC transporter
CLC99_RS05725	COG1131	(ABC) transporter
CLC99_RS05730	COG0537	adenosine 5'-monophosphoramidase activity
CLC99_RS05740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CLC99_RS05770	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLC99_RS05780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CLC99_RS05795	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CLC99_RS05800	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CLC99_RS05800	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CLC99_RS05805	COG0307	riboflavin synthase, alpha
CLC99_RS05810	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CLC99_RS05810	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CLC99_RS05830	COG0463	Glycosyl transferase, family 2
CLC99_RS05835	COG0586	Pfam SNARE associated Golgi protein
CLC99_RS05840	COG0463	Glycosyl transferase, family 2
CLC99_RS05850	COG0745	RESPONSE REGULATOR receiver
CLC99_RS05855	COG3850	Histidine kinase
CLC99_RS05855	COG5002	protein histidine kinase activity
CLC99_RS05885	COG0583	DNA-binding transcription factor activity
CLC99_RS05900	COG3481	metal-dependent phosphohydrolase, HD sub domain
CLC99_RS05905	COG4717	serine-type aminopeptidase activity
CLC99_RS05910	COG0420	3'-5' exonuclease activity
CLC99_RS05915	COG3679	Belongs to the UPF0342 family
CLC99_RS05920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CLC99_RS05930	COG1438	arginine binding
CLC99_RS05935	COG0436	Aminotransferase
CLC99_RS05945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLC99_RS05950	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CLC99_RS05955	COG1376	ErfK ybiS ycfS ynhG family protein
CLC99_RS05965	COG2723	6-phospho-beta-galactosidase activity
CLC99_RS05970	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CLC99_RS05975	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CLC99_RS05980	COG1447	Phosphotransferase system cellobiose-specific component IIA
CLC99_RS06000	COG1136	(ABC) transporter
CLC99_RS06000	COG0577	efflux transmembrane transporter activity
CLC99_RS06010	COG0018	arginyl-trna synthetase
CLC99_RS06015	COG2153	protein acetylation
CLC99_RS06035	COG0534	Mate efflux family protein
CLC99_RS06040	COG0471	metal ion transport
CLC99_RS06040	COG3273	potassium ion transport
CLC99_RS06050	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CLC99_RS06055	COG0529	Catalyzes the synthesis of activated sulfate
CLC99_RS06060	COG2046	Belongs to the sulfate adenylyltransferase family
CLC99_RS06070	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CLC99_RS06075	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CLC99_RS06075	COG0646	methionine synthase
CLC99_RS06340	COG1396	sequence-specific DNA binding
CLC99_RS06350	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CLC99_RS06375	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CLC99_RS06390	COG1846	Transcriptional regulator
CLC99_RS06410	COG3279	Response regulator of the LytR AlgR family
CLC99_RS06430	COG0561	phosphatase activity
CLC99_RS06445	COG0789	Transcriptional regulator
CLC99_RS06450	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CLC99_RS06480	COG1511	domain protein
CLC99_RS06480	COG1511	domain protein
CLC99_RS06485	COG1970	mechanosensitive ion channel activity
CLC99_RS06490	COG1428	Deoxynucleoside kinase
CLC99_RS06495	COG0584	glycerophosphoryl diester phosphodiesterase
CLC99_RS06510	COG1175	transmembrane transport
CLC99_RS06525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CLC99_RS06530	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CLC99_RS06535	COG1187	pseudouridine synthase activity
CLC99_RS06540	COG2244	polysaccharide biosynthetic process
CLC99_RS06545	COG0495	leucyl-tRNA aminoacylation
CLC99_RS06555	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CLC99_RS06570	COG0438	transferase activity, transferring glycosyl groups
CLC99_RS06585	COG0477	Major facilitator Superfamily
CLC99_RS06590	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CLC99_RS06600	COG0438	transferase activity, transferring glycosyl groups
CLC99_RS06605	COG2040	homocysteine
CLC99_RS06610	COG0833	amino acid
CLC99_RS06615	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CLC99_RS06630	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CLC99_RS06650	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CLC99_RS06740	COG1368	sulfuric ester hydrolase activity
CLC99_RS06745	COG4703	Protein of unknown function (DUF1797)
CLC99_RS06755	COG1686	Belongs to the peptidase S11 family
CLC99_RS06765	COG0438	transferase activity, transferring glycosyl groups
CLC99_RS06770	COG0438	transferase activity, transferring glycosyl groups
CLC99_RS06790	COG0542	response to heat
CLC99_RS06795	COG0582	viral genome integration into host DNA
CLC99_RS06805	COG4608	Belongs to the ABC transporter superfamily
CLC99_RS06810	COG0444	Belongs to the ABC transporter superfamily
CLC99_RS06815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLC99_RS06820	COG0601	transmembrane transport
CLC99_RS06825	COG4166	transmembrane transport
CLC99_RS06855	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CLC99_RS06860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CLC99_RS06865	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CLC99_RS06870	COG1070	Carbohydrate kinase
CLC99_RS06875	COG2610	gluconate transmembrane transporter activity
CLC99_RS06880	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CLC99_RS06885	COG0628	permease
CLC99_RS06895	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CLC99_RS06915	COG3557	Belongs to the UPF0374 family
CLC99_RS06920	COG2137	regulation of response to DNA damage stimulus
CLC99_RS06955	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CLC99_RS06975	COG2207	Transcriptional regulator
CLC99_RS06975	COG1609	Transcriptional regulator
CLC99_RS07010	COG0562	UDP-galactopyranose mutase
CLC99_RS07110	COG5039	Polysaccharide pyruvyl transferase
CLC99_RS07125	COG0438	transferase activity, transferring glycosyl groups
CLC99_RS07135	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CLC99_RS07145	COG4464	protein tyrosine phosphatase activity
CLC99_RS07150	COG0489	protein tyrosine kinase activity
CLC99_RS07160	COG0582	viral genome integration into host DNA
CLC99_RS07165	COG1088	dTDP-glucose 4,6-dehydratase activity
CLC99_RS07175	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CLC99_RS07180	COG2244	polysaccharide biosynthetic process
CLC99_RS07225	COG0562	UDP-galactopyranose mutase
CLC99_RS07230	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CLC99_RS07240	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CLC99_RS07250	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CLC99_RS07275	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CLC99_RS07540	COG0513	Belongs to the DEAD box helicase family
CLC99_RS07545	COG0673	inositol 2-dehydrogenase activity
CLC99_RS07550	COG1278	Cold shock
CLC99_RS07565	COG1737	Transcriptional regulator
CLC99_RS07575	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CLC99_RS07590	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CLC99_RS07595	COG1597	lipid kinase activity
CLC99_RS07600	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CLC99_RS07605	COG0154	amidase activity
CLC99_RS07610	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CLC99_RS07615	COG4851	CamS sex pheromone cAM373 precursor
CLC99_RS07620	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CLC99_RS07630	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CLC99_RS07635	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CLC99_RS07640	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CLC99_RS07645	COG1705	Flagellar rod assembly protein muramidase FlgJ
CLC99_RS07660	COG0142	geranyltranstransferase activity
CLC99_RS07675	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CLC99_RS07680	COG4988	ABC transporter
CLC99_RS07685	COG1294	oxidase, subunit
CLC99_RS07690	COG1271	oxidase subunit
CLC99_RS07705	COG4684	Psort location CytoplasmicMembrane, score
CLC99_RS07710	COG0531	amino acid
CLC99_RS07720	COG0281	malic enzyme
CLC99_RS07725	COG0583	DNA-binding transcription factor activity
CLC99_RS07735	COG0583	DNA-binding transcription factor activity
CLC99_RS07745	COG1053	succinate dehydrogenase
CLC99_RS07750	COG0114	fumarate hydratase activity
CLC99_RS07770	COG3052	prosthetic group binding
CLC99_RS07790	COG0471	metal ion transport
CLC99_RS07795	COG0039	L-malate dehydrogenase activity
CLC99_RS07805	COG0803	Belongs to the bacterial solute-binding protein 9 family
CLC99_RS07810	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CLC99_RS07815	COG1121	(ABC) transporter
CLC99_RS07820	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
CLC99_RS07825	COG1917	Cupin 2, conserved barrel domain protein
CLC99_RS07825	COG4977	sequence-specific DNA binding
CLC99_RS07835	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CLC99_RS07840	COG2151	metal-sulfur cluster biosynthetic enzyme
CLC99_RS07845	COG0471	metal ion transport
CLC99_RS07850	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CLC99_RS07855	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CLC99_RS07860	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CLC99_RS07865	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CLC99_RS07885	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CLC99_RS08005	COG1783	phage Terminase large subunit
CLC99_RS08145	COG1396	sequence-specific DNA binding
CLC99_RS08180	COG0166	Belongs to the GPI family
CLC99_RS08185	COG4975	Glucose uptake
CLC99_RS08190	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CLC99_RS08195	COG3850	Histidine kinase
CLC99_RS08195	COG5002	protein histidine kinase activity
CLC99_RS08200	COG0745	RESPONSE REGULATOR receiver
CLC99_RS08205	COG2848	UPF0210 protein
CLC99_RS08210	COG3830	Belongs to the UPF0237 family
CLC99_RS08235	COG0477	Major facilitator Superfamily
CLC99_RS08255	COG0791	NLP P60 protein
CLC99_RS08260	COG1522	sequence-specific DNA binding
CLC99_RS08280	COG0488	(ABC) transporter
CLC99_RS08310	COG2190	(PTS) system
CLC99_RS08310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLC99_RS08310	COG1263	PTS System
CLC99_RS08315	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CLC99_RS08320	COG1307	EDD domain protein, DegV family
CLC99_RS08330	COG2873	o-acetylhomoserine
CLC99_RS08335	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CLC99_RS08350	COG4120	Belongs to the binding-protein-dependent transport system permease family
CLC99_RS08360	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLC99_RS08375	COG2084	Dehydrogenase
CLC99_RS08380	COG0861	Integral membrane protein TerC family
CLC99_RS08385	COG0110	maltose O-acetyltransferase activity
CLC99_RS08390	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CLC99_RS08395	COG0140	phosphoribosyl-ATP diphosphatase activity
CLC99_RS08400	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CLC99_RS08405	COG0107	imidazoleglycerol-phosphate synthase activity
CLC99_RS08410	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CLC99_RS08415	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CLC99_RS08420	COG0131	Imidazoleglycerol-phosphate dehydratase
CLC99_RS08425	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CLC99_RS08430	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CLC99_RS08435	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CLC99_RS08440	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CLC99_RS08465	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CLC99_RS08480	COG3548	integral membrane protein
CLC99_RS08500	COG1368	sulfuric ester hydrolase activity
CLC99_RS08505	COG0584	glycerophosphoryl diester phosphodiesterase
CLC99_RS08515	COG0492	ferredoxin-NADP+ reductase activity
CLC99_RS08525	COG4932	domain protein
CLC99_RS08530	COG2326	polyphosphate kinase activity
CLC99_RS08535	COG0778	Nitroreductase
CLC99_RS08545	COG0328	RNA-DNA hybrid ribonuclease activity
CLC99_RS08550	COG4975	Glucose uptake
CLC99_RS08565	COG1349	DNA-binding transcription factor activity
CLC99_RS08570	COG1882	Formate acetyltransferase
CLC99_RS08590	COG1609	Transcriptional regulator
CLC99_RS08595	COG1737	Transcriptional regulator
CLC99_RS08600	COG0673	inositol 2-dehydrogenase activity
CLC99_RS08605	COG0673	inositol 2-dehydrogenase activity
CLC99_RS08610	COG0025	NhaP-type Na H and K H
CLC99_RS08615	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CLC99_RS08620	COG1335	isochorismatase
CLC99_RS08630	COG1131	(ABC) transporter
CLC99_RS08635	COG1725	Transcriptional regulator
CLC99_RS08675	COG0028	Belongs to the TPP enzyme family
CLC99_RS08685	COG1073	alpha beta
CLC99_RS08690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CLC99_RS08695	COG0626	cystathionine gamma-synthase activity
CLC99_RS08725	COG0095	Lipoate-protein ligase
CLC99_RS08730	COG1705	Flagellar rod assembly protein muramidase FlgJ
CLC99_RS08740	COG3716	PTS system mannose fructose sorbose family IID component
CLC99_RS08745	COG3715	PTS system
CLC99_RS08750	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLC99_RS08755	COG2188	Transcriptional regulator
CLC99_RS08760	COG0589	response to stress
CLC99_RS08765	COG0564	pseudouridine synthase activity
CLC99_RS08770	COG1396	sequence-specific DNA binding
CLC99_RS08785	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CLC99_RS08795	COG2188	Transcriptional regulator
CLC99_RS08800	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CLC99_RS08810	COG1418	mRNA catabolic process
CLC99_RS08840	COG1253	flavin adenine dinucleotide binding
CLC99_RS08845	COG1780	Probably involved in ribonucleotide reductase function
CLC99_RS08850	COG0025	NhaP-type Na H and K H
CLC99_RS08855	COG2814	Major facilitator Superfamily
CLC99_RS08860	COG0789	Transcriptional regulator
CLC99_RS08865	COG0604	alcohol dehydrogenase
CLC99_RS08875	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CLC99_RS08885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLC99_RS08890	COG0436	Aminotransferase
CLC99_RS08910	COG0583	DNA-binding transcription factor activity
CLC99_RS08915	COG0702	epimerase
CLC99_RS08925	COG1074	ATP-dependent DNA helicase activity
CLC99_RS08930	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CLC99_RS08940	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CLC99_RS08945	COG0284	orotidine-5'-phosphate decarboxylase activity
CLC99_RS08950	COG0167	dihydroorotate dehydrogenase activity
CLC99_RS08960	COG0505	Belongs to the CarA family
CLC99_RS08965	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CLC99_RS08970	COG0540	Belongs to the ATCase OTCase family
CLC99_RS08975	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CLC99_RS08980	COG2508	Transcriptional regulator
CLC99_RS08985	COG2233	PERMEase
CLC99_RS08990	COG2252	PERMEase
CLC99_RS09010	COG1215	transferase activity, transferring glycosyl groups
CLC99_RS09020	COG0151	Belongs to the GarS family
CLC99_RS09025	COG0138	bifunctional purine biosynthesis protein purh
CLC99_RS09030	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CLC99_RS09035	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CLC99_RS09045	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CLC99_RS09050	COG0047	phosphoribosylformylglycinamidine synthase activity
CLC99_RS09055	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CLC99_RS09060	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CLC99_RS09065	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CLC99_RS09075	COG0431	NADPH-dependent FMN reductase
CLC99_RS09075	COG3976	FMN-binding domain protein
CLC99_RS09075	COG1053	succinate dehydrogenase
CLC99_RS09080	COG3976	FMN-binding domain protein
CLC99_RS09080	COG0431	NADPH-dependent FMN reductase
CLC99_RS09080	COG1053	succinate dehydrogenase
CLC99_RS09085	COG0095	Lipoate-protein ligase
CLC99_RS09090	COG2365	Tyrosine phosphatase family
CLC99_RS09115	COG1136	(ABC) transporter
CLC99_RS09130	COG1725	Transcriptional regulator
CLC99_RS09135	COG1131	(ABC) transporter
CLC99_RS09145	COG0589	response to stress
CLC99_RS09155	COG2246	polysaccharide biosynthetic process
CLC99_RS09175	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CLC99_RS09195	COG0366	Alpha amylase catalytic
CLC99_RS09205	COG0561	phosphatase activity
CLC99_RS09215	COG0110	maltose O-acetyltransferase activity
CLC99_RS09220	COG0494	nUDIX hydrolase
CLC99_RS09255	COG1827	regulation of RNA biosynthetic process
CLC99_RS09260	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CLC99_RS09265	COG1309	transcriptional regulator
CLC99_RS09275	COG1131	(ABC) transporter
CLC99_RS09280	COG3048	D-serine ammonia-lyase activity
CLC99_RS09285	COG2723	6-phospho-beta-galactosidase activity
CLC99_RS09290	COG2723	6-phospho-beta-galactosidase activity
CLC99_RS09295	COG1447	Phosphotransferase system cellobiose-specific component IIA
CLC99_RS09300	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CLC99_RS09305	COG2188	Transcriptional regulator
CLC99_RS09310	COG1216	Glycosyl transferase, family 2
CLC99_RS09325	COG0561	phosphatase activity
CLC99_RS09330	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CLC99_RS09355	COG0716	FMN binding
CLC99_RS09375	COG0710	3-dehydroquinate dehydratase activity
CLC99_RS09380	COG0531	amino acid
CLC99_RS09425	COG4720	Psort location CytoplasmicMembrane, score
CLC99_RS09430	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CLC99_RS09445	COG4990	cell redox homeostasis
CLC99_RS09455	COG1811	Na channel or pump
CLC99_RS09460	COG0789	Transcriptional regulator
CLC99_RS09460	COG4978	Transcriptional regulator
CLC99_RS09475	COG0577	efflux transmembrane transporter activity
CLC99_RS09480	COG1136	(ABC) transporter
CLC99_RS09520	COG2814	Major facilitator Superfamily
CLC99_RS09530	COG2814	Major facilitator Superfamily
CLC99_RS09540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CLC99_RS09545	COG2855	membrane
CLC99_RS09550	COG0583	DNA-binding transcription factor activity
CLC99_RS09560	COG0438	transferase activity, transferring glycosyl groups
CLC99_RS09575	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CLC99_RS09585	COG4152	abc transporter atp-binding protein
CLC99_RS09595	COG4221	oxidoreductase activity
CLC99_RS09610	COG0789	Transcriptional regulator
CLC99_RS09630	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CLC99_RS09655	COG0456	acetyltransferase
CLC99_RS09680	COG0583	DNA-binding transcription factor activity
CLC99_RS09690	COG1063	alcohol dehydrogenase
CLC99_RS09695	COG1028	Short-chain dehydrogenase reductase Sdr
CLC99_RS09700	COG0656	L-ascorbic acid biosynthetic process
CLC99_RS09730	COG0656	L-ascorbic acid biosynthetic process
CLC99_RS09735	COG0583	DNA-binding transcription factor activity
CLC99_RS09755	COG4221	oxidoreductase activity
CLC99_RS09760	COG0656	L-ascorbic acid biosynthetic process
CLC99_RS09780	COG0589	response to stress
CLC99_RS09785	COG0110	maltose O-acetyltransferase activity
CLC99_RS09790	COG1011	Hydrolase
CLC99_RS09805	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CLC99_RS09815	COG0667	Aldo Keto reductase
CLC99_RS09820	COG1132	(ABC) transporter
CLC99_RS09825	COG1132	(ABC) transporter
CLC99_RS09830	COG2814	Major facilitator Superfamily
CLC99_RS09845	COG1511	domain protein
CLC99_RS09845	COG1511	domain protein
CLC99_RS09855	COG0640	Transcriptional regulator
CLC99_RS09880	COG0488	(ABC) transporter
CLC99_RS09885	COG0561	phosphatase activity
CLC99_RS09895	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CLC99_RS09910	COG2270	Major facilitator Superfamily
CLC99_RS09950	COG2200	EAL domain
CLC99_RS09960	COG1328	CTP reductase activity
CLC99_RS09970	COG0242	peptide deformylase activity
CLC99_RS09980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CLC99_RS10005	COG0583	DNA-binding transcription factor activity
CLC99_RS10015	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CLC99_RS10075	COG0697	spore germination
CLC99_RS10100	COG1940	carbohydrate kinase activity
CLC99_RS10105	COG1132	(ABC) transporter
CLC99_RS10115	COG0778	Nitroreductase
CLC99_RS10120	COG2190	(PTS) system
CLC99_RS10120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLC99_RS10120	COG1263	PTS System
CLC99_RS10130	COG4120	Belongs to the binding-protein-dependent transport system permease family
CLC99_RS10160	COG0617	tRNA 3'-terminal CCA addition
CLC99_RS10160	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CLC99_RS10160	COG3620	sequence-specific DNA binding
CLC99_RS10165	COG0410	ABC transporter
CLC99_RS10180	COG0559	Belongs to the binding-protein-dependent transport system permease family
CLC99_RS10195	COG5549	protein import
CLC99_RS10195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CLC99_RS10200	COG2246	polysaccharide biosynthetic process
CLC99_RS10210	COG1914	H( )-stimulated, divalent metal cation uptake system
CLC99_RS10230	COG0640	Transcriptional regulator
CLC99_RS10240	COG0577	efflux transmembrane transporter activity
CLC99_RS10240	COG1136	(ABC) transporter
CLC99_RS10275	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CLC99_RS10280	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CLC99_RS10285	COG2723	6-phospho-beta-galactosidase activity
CLC99_RS10295	COG0789	Transcriptional regulator
CLC99_RS10300	COG0741	lytic transglycosylase activity
CLC99_RS10320	COG0803	Belongs to the bacterial solute-binding protein 9 family
CLC99_RS10345	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CLC99_RS10360	COG4221	oxidoreductase activity
CLC99_RS10405	COG1132	(ABC) transporter
CLC99_RS10410	COG1132	(ABC) transporter
CLC99_RS10420	COG1473	amidohydrolase
CLC99_RS10425	COG1028	Short-chain dehydrogenase reductase Sdr
CLC99_RS10440	COG0531	amino acid
CLC99_RS10470	COG2217	Heavy metal translocating P-type atpase
CLC99_RS10530	COG1063	alcohol dehydrogenase
CLC99_RS10570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CLC99_RS10575	COG1733	regulation of RNA biosynthetic process
CLC99_RS10580	COG2814	Major facilitator Superfamily
CLC99_RS10590	COG0367	asparagine synthase
CLC99_RS10595	COG3279	Response regulator of the LytR AlgR family
CLC99_RS10610	COG1309	transcriptional regulator
CLC99_RS10620	COG1012	belongs to the aldehyde dehydrogenase family
CLC99_RS10635	COG1733	regulation of RNA biosynthetic process
CLC99_RS10640	COG0300	oxidoreductase activity
CLC99_RS10660	COG4989	oxidoreductase activity
CLC99_RS10665	COG0477	Major facilitator Superfamily
CLC99_RS10675	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CLC99_RS10680	COG1120	ATPase activity
CLC99_RS10690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLC99_RS10695	COG1309	transcriptional regulator
CLC99_RS10705	COG4221	oxidoreductase activity
CLC99_RS10710	COG0110	maltose O-acetyltransferase activity
CLC99_RS10715	COG1028	Short-chain dehydrogenase reductase Sdr
CLC99_RS10750	COG0481	GTPase activity
CLC99_RS10760	COG2816	NAD+ diphosphatase activity
CLC99_RS10770	COG1053	succinate dehydrogenase
CLC99_RS10780	COG0783	Belongs to the Dps family
CLC99_RS10790	COG2723	6-phospho-beta-galactosidase activity
CLC99_RS10795	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CLC99_RS10815	COG0789	Transcriptional regulator
CLC99_RS10835	COG0693	protein deglycase activity
CLC99_RS10860	COG0577	efflux transmembrane transporter activity
CLC99_RS10860	COG1136	(ABC) transporter
CLC99_RS10870	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CLC99_RS10890	COG1376	ErfK ybiS ycfS ynhG family protein
CLC99_RS10895	COG0656	L-ascorbic acid biosynthetic process
CLC99_RS10910	COG0477	Major facilitator Superfamily
CLC99_RS10945	COG0588	phosphoglycerate mutase activity
CLC99_RS10950	COG0628	permease
CLC99_RS10955	COG1846	Transcriptional regulator
CLC99_RS10955	COG1940	carbohydrate kinase activity
CLC99_RS10965	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CLC99_RS10975	COG2815	serine threonine protein kinase
CLC99_RS10975	COG0515	serine threonine protein kinase
CLC99_RS11015	COG1247	-acetyltransferase
CLC99_RS11020	COG1686	Belongs to the peptidase S11 family
CLC99_RS11040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CLC99_RS11045	COG0517	IMP dehydrogenase activity
CLC99_RS11045	COG0516	GMP reductase activity
CLC99_RS11060	COG0012	GTP binding
CLC99_RS11065	COG4481	Protein conserved in bacteria
CLC99_RS11070	COG1475	DNA binding
CLC99_RS11075	COG1192	Involved in chromosome partitioning
CLC99_RS11085	COG0357	Ribosomal RNA small subunit methyltransferase G
CLC99_RS11090	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CLC99_RS11105	COG0583	DNA-binding transcription factor activity
CLC99_RS11110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLC99_RS11115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLC99_RS11120	COG0765	amino acid transport
CLC99_RS11125	COG1126	abc transporter atp-binding protein
CLC99_RS11130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLC99_RS11155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLC99_RS11155	COG2190	(PTS) system
CLC99_RS11155	COG1263	PTS System
CLC99_RS11160	COG0366	Alpha amylase catalytic
CLC99_RS11165	COG1609	Transcriptional regulator
CLC99_RS11180	COG0390	transport system, permease component
CLC99_RS11185	COG4619	ABC transporter
CLC99_RS11190	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CLC99_RS11205	COG0561	phosphatase activity
CLC99_RS11215	COG0383	alpha-mannosidase activity
CLC99_RS11220	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLC99_RS11220	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CLC99_RS11220	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CLC99_RS11225	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CLC99_RS11230	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CLC99_RS11230	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CLC99_RS11230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLC99_RS11235	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLC99_RS11235	COG3711	transcriptional antiterminator
CLC99_RS11250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLC99_RS11250	COG2190	(PTS) system
CLC99_RS11250	COG1263	PTS System
CLC99_RS11280	COG0735	belongs to the Fur family
CLC99_RS11305	COG1380	Effector of murein hydrolase LrgA
CLC99_RS11315	COG1307	EDD domain protein, DegV family
CLC99_RS11325	COG2738	Putative neutral zinc metallopeptidase
CLC99_RS11330	COG1233	COG1233 Phytoene dehydrogenase and related
CLC99_RS11335	COG1562	ergosterol biosynthetic process
CLC99_RS11345	COG1929	Belongs to the glycerate kinase type-1 family
CLC99_RS11360	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CLC99_RS11365	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CLC99_RS11370	COG0516	GMP reductase activity
CLC99_RS11375	COG2365	Tyrosine phosphatase family
CLC99_RS11380	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CLC99_RS11390	COG0531	amino acid
CLC99_RS11395	COG3158	transport of potassium into the cell
CLC99_RS11410	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CLC99_RS11415	COG0628	permease
CLC99_RS11420	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CLC99_RS11435	COG1272	protein, Hemolysin III
CLC99_RS11440	COG0640	Transcriptional regulator
CLC99_RS11475	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CLC99_RS11485	COG0302	gtp cyclohydrolase
CLC99_RS11490	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CLC99_RS11510	COG0803	Belongs to the bacterial solute-binding protein 9 family
CLC99_RS11515	COG2814	Major facilitator Superfamily
CLC99_RS11545	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CLC99_RS11550	COG1882	Formate acetyltransferase
CLC99_RS11555	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CLC99_RS11565	COG2151	metal-sulfur cluster biosynthetic enzyme
CLC99_RS11570	COG4989	oxidoreductase activity
CLC99_RS11595	COG2217	Heavy metal translocating P-type atpase
CLC99_RS11605	COG2315	Protein conserved in bacteria
CLC99_RS11615	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CLC99_RS11620	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CLC99_RS11635	COG1757	Na H antiporter
CLC99_RS11640	COG1113	amino acid transport
CLC99_RS11650	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CLC99_RS11665	COG1393	Belongs to the ArsC family
CLC99_RS11670	COG3189	MarR family transcriptional regulator
CLC99_RS11680	COG1194	a g-specific adenine glycosylase
CLC99_RS11695	COG0071	Belongs to the small heat shock protein (HSP20) family
CLC99_RS11720	COG0697	spore germination
CLC99_RS11735	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
CLC99_RS11760	COG0477	Major facilitator Superfamily
CLC99_RS11825	COG0737	Belongs to the 5'-nucleotidase family
CLC99_RS11835	COG0656	L-ascorbic acid biosynthetic process
CLC99_RS11855	COG1968	undecaprenyl-diphosphatase activity
CLC99_RS11860	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CLC99_RS11895	COG2207	Transcriptional regulator
CLC99_RS11920	COG0076	glutamate decarboxylase activity
CLC99_RS11970	COG2226	methyltransferase
CLC99_RS11990	COG2217	Heavy metal translocating P-type atpase
CLC99_RS11995	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CLC99_RS12000	COG3118	belongs to the thioredoxin family
CLC99_RS12005	COG1937	Protein conserved in bacteria
CLC99_RS12025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CLC99_RS12030	COG3590	peptidase
CLC99_RS12055	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLC99_RS12105	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CLC99_RS12115	COG1114	Component of the transport system for branched-chain amino acids
CLC99_RS12125	COG1874	Beta-galactosidase
CLC99_RS12130	COG1609	Transcriptional regulator
CLC99_RS12140	COG0477	Major facilitator Superfamily
CLC99_RS12160	COG2184	nucleotidyltransferase activity
CLC99_RS12165	COG2944	sequence-specific DNA binding
CLC99_RS12170	COG1609	Transcriptional regulator
CLC99_RS12175	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CLC99_RS12180	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CLC99_RS12185	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CLC99_RS12205	COG2190	(PTS) system
CLC99_RS12205	COG2211	Major facilitator Superfamily
CLC99_RS12210	COG2017	converts alpha-aldose to the beta-anomer
CLC99_RS12215	COG1609	Transcriptional regulator
CLC99_RS12220	COG0667	Aldo Keto reductase
CLC99_RS12240	COG0710	3-dehydroquinate dehydratase activity
CLC99_RS12245	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CLC99_RS12250	COG0583	DNA-binding transcription factor activity
CLC99_RS12255	COG2271	Major facilitator Superfamily
CLC99_RS12270	COG1028	Short-chain dehydrogenase reductase Sdr
CLC99_RS12285	COG2271	Major facilitator Superfamily
CLC99_RS12295	COG2267	carboxylic ester hydrolase activity
CLC99_RS12300	COG2188	Transcriptional regulator
CLC99_RS12305	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CLC99_RS12310	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CLC99_RS12315	COG2971	BadF BadG BcrA BcrD
CLC99_RS12325	COG2723	6-phospho-beta-galactosidase activity
CLC99_RS12335	COG3711	transcriptional antiterminator
CLC99_RS12340	COG2723	6-phospho-beta-galactosidase activity
CLC99_RS12345	COG2723	6-phospho-beta-galactosidase activity
CLC99_RS12350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLC99_RS12350	COG1263	PTS System
CLC99_RS12350	COG2190	(PTS) system
CLC99_RS12370	COG2211	Major facilitator Superfamily
CLC99_RS12385	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
CLC99_RS12400	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CLC99_RS12420	COG3711	transcriptional antiterminator
CLC99_RS12435	COG3775	system Galactitol-specific IIC component
CLC99_RS12440	COG3414	Phosphotransferase system galactitol-specific IIB component
CLC99_RS12450	COG1349	DNA-binding transcription factor activity
CLC99_RS12455	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CLC99_RS12465	COG0110	maltose O-acetyltransferase activity
CLC99_RS12470	COG2160	L-arabinose isomerase activity
CLC99_RS12495	COG1737	Transcriptional regulator
CLC99_RS12515	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CLC99_RS12535	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CLC99_RS12540	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CLC99_RS12570	COG2261	transglycosylase associated protein
CLC99_RS12580	COG1393	Belongs to the ArsC family
CLC99_RS12600	COG4512	PFAM Accessory gene regulator B
CLC99_RS12615	COG1304	FMN binding
CLC99_RS12620	COG0028	Belongs to the TPP enzyme family
CLC99_RS12625	COG1959	2 iron, 2 sulfur cluster binding
CLC99_RS12630	COG0028	Belongs to the TPP enzyme family
CLC99_RS12645	COG0235	Class ii aldolase
CLC99_RS12650	COG4806	L-rhamnose isomerase
CLC99_RS12655	COG3254	rhamnose metabolic process
CLC99_RS12660	COG1070	Carbohydrate kinase
CLC99_RS12665	COG2814	Major facilitator Superfamily
CLC99_RS12670	COG2207	Transcriptional regulator
CLC99_RS12675	COG1349	DNA-binding transcription factor activity
CLC99_RS12755	COG2207	Transcriptional regulator
CLC99_RS12755	COG1609	Transcriptional regulator
CLC99_RS12805	COG2723	6-phospho-beta-galactosidase activity
CLC99_RS12810	COG1940	carbohydrate kinase activity
CLC99_RS12815	COG0383	alpha-mannosidase activity
CLC99_RS12825	COG2188	Transcriptional regulator
CLC99_RS12835	COG3842	ATPase activity
CLC99_RS12845	COG4753	response regulator
CLC99_RS12845	COG2207	Transcriptional regulator
CLC99_RS12850	COG2972	Histidine kinase
CLC99_RS12860	COG0366	Alpha amylase catalytic
CLC99_RS12865	COG1653	transport
CLC99_RS12870	COG0395	ABC-type sugar transport system, permease component
CLC99_RS12885	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CLC99_RS12885	COG2207	Transcriptional regulator
CLC99_RS12890	COG1132	(ABC) transporter
CLC99_RS12895	COG1132	(ABC) transporter
CLC99_RS12900	COG2188	Transcriptional regulator
CLC99_RS12915	COG3732	PTS system glucitol sorbitol-specific
CLC99_RS12920	COG3730	PTS system glucitol sorbitol-specific
CLC99_RS12940	COG4975	Glucose uptake
CLC99_RS12945	COG1869	D-ribose catabolic process
CLC99_RS12955	COG1609	Transcriptional regulator
CLC99_RS12970	COG1695	Transcriptional regulator
CLC99_RS12975	COG3479	Phenolic acid decarboxylase
CLC99_RS12990	COG1307	EDD domain protein, DegV family
CLC99_RS13030	COG0445	tRNA wobble uridine modification
CLC99_RS13035	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CLC99_RS13040	COG1847	R3H domain protein
CLC99_RS13050	COG4166	transmembrane transport
CLC99_RS13055	COG0706	membrane insertase activity
CLC99_RS13060	COG0594	ribonuclease P activity
CLC99_RS13065	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CLC99_RS13070	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CLC99_RS13075	COG0592	DNA-directed DNA polymerase activity
CLC99_RS13080	COG2501	S4 domain
CLC99_RS13085	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CLC99_RS13090	COG0187	DNA topoisomerase II activity
CLC99_RS13100	COG0360	Binds together with S18 to 16S ribosomal RNA
CLC99_RS13105	COG0629	single-stranded DNA binding
CLC99_RS13110	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CLC99_RS13120	COG0359	binds to the 23S rRNA
CLC99_RS13125	COG0305	Participates in initiation and elongation during chromosome replication
CLC99_RS13130	COG2814	Major facilitator Superfamily
CLC99_RS13135	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CLC99_RS13140	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CLC99_RS13145	COG4166	transmembrane transport
CLC99_RS13155	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CLC99_RS13160	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CLC99_RS13165	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CLC99_RS13170	COG0297	glycogen (starch) synthase activity
CLC99_RS13175	COG0058	SHG alpha-glucan phosphorylase activity
CLC99_RS13180	COG0366	Alpha amylase catalytic
CLC99_RS13180	COG3103	Sh3 type 3 domain protein
CLC99_RS13190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CLC99_RS13205	COG1278	Cold shock
CLC99_RS13220	COG1396	sequence-specific DNA binding
CLC99_RS13290	COG4695	Portal protein
CLC99_RS13315	COG2226	methyltransferase
CLC99_RS13325	COG0745	RESPONSE REGULATOR receiver
CLC99_RS13330	COG5002	protein histidine kinase activity
CLC99_RS13340	COG4853	Protein conserved in bacteria
CLC99_RS13345	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CLC99_RS13350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CLC99_RS13355	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CLC99_RS13365	COG1012	belongs to the aldehyde dehydrogenase family
CLC99_RS13375	COG1573	uracil-dna glycosylase
CLC99_RS13395	COG1053	succinate dehydrogenase
CLC99_RS13395	COG0431	NADPH-dependent FMN reductase
CLC99_RS13395	COG3976	FMN-binding domain protein
CLC99_RS13400	COG0471	metal ion transport
CLC99_RS13415	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CLC99_RS13420	COG1028	Short-chain dehydrogenase reductase Sdr
CLC99_RS13430	COG0778	Nitroreductase
CLC99_RS13435	COG2508	Transcriptional regulator
CLC99_RS13445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CLC99_RS13450	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
CLC99_RS13460	COG2365	Tyrosine phosphatase family
CLC99_RS13465	COG2368	4-hydroxyphenylacetate
CLC99_RS13485	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CLC99_RS13520	COG0604	alcohol dehydrogenase
CLC99_RS13545	COG2267	carboxylic ester hydrolase activity
CLC99_RS13550	COG3022	response to hydroperoxide
CLC99_RS13560	COG4166	transmembrane transport
CLC99_RS13585	COG1122	ATPase activity
CLC99_RS13590	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CLC99_RS13595	COG0310	cobalt ion transport
CLC99_RS13600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CLC99_RS13605	COG3875	lactate racemase activity
CLC99_RS13610	COG1691	(AIR) carboxylase
CLC99_RS13615	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CLC99_RS13620	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CLC99_RS13625	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CLC99_RS13630	COG1606	tRNA processing
CLC99_RS13640	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CLC99_RS13645	COG0351	phosphomethylpyrimidine kinase
CLC99_RS13650	COG0352	thiamine-phosphate diphosphorylase activity
CLC99_RS13660	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CLC99_RS13675	COG1113	amino acid transport
CLC99_RS13685	COG2267	carboxylic ester hydrolase activity
CLC99_RS13690	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CLC99_RS13700	COG1983	PspC domain protein
CLC99_RS13740	COG2807	transmembrane transport
CLC99_RS13745	COG0656	L-ascorbic acid biosynthetic process
CLC99_RS13750	COG0667	Aldo Keto reductase
CLC99_RS13780	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CLC99_RS13785	COG1122	ATPase activity
CLC99_RS13790	COG4720	Psort location CytoplasmicMembrane, score
CLC99_RS13800	COG2188	Transcriptional regulator
CLC99_RS13825	COG1028	Short-chain dehydrogenase reductase Sdr
CLC99_RS13830	COG1131	(ABC) transporter
CLC99_RS13845	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CLC99_RS13850	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CLC99_RS13855	COG1309	transcriptional regulator
CLC99_RS13860	COG2376	Dihydroxyacetone kinase
CLC99_RS13865	COG2376	Dihydroxyacetone kinase
CLC99_RS13870	COG1461	Dihydroxyacetone kinase
CLC99_RS13875	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CLC99_RS13880	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CLC99_RS13885	COG1609	Transcriptional regulator
CLC99_RS13890	COG1609	Transcriptional regulator
CLC99_RS13895	COG0366	Alpha amylase catalytic
CLC99_RS13900	COG2182	Extracellular solute-binding protein
CLC99_RS13905	COG1175	transmembrane transport
CLC99_RS13910	COG3833	ABC-type maltose transport systems, permease component
CLC99_RS13920	COG0366	Alpha amylase catalytic
CLC99_RS13925	COG3842	ATPase activity
CLC99_RS13975	COG1757	Na H antiporter
CLC99_RS14005	COG4166	transmembrane transport
CLC99_RS14015	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CLC99_RS14020	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CLC99_RS14025	COG0406	alpha-ribazole phosphatase activity
CLC99_RS14030	COG0667	Aldo Keto reductase
CLC99_RS14060	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CLC99_RS14065	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CLC99_RS14070	COG0488	(ABC) transporter
CLC99_RS14080	COG4172	Belongs to the ABC transporter superfamily
CLC99_RS14090	COG0386	Belongs to the glutathione peroxidase family
CLC99_RS14100	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CLC99_RS14115	COG0363	glucosamine-6-phosphate deaminase activity
CLC99_RS14125	COG2213	PTS system mannitol-specific
CLC99_RS14135	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLC99_RS14140	COG0246	Mannitol dehydrogenase
CLC99_RS14150	COG3118	belongs to the thioredoxin family
CLC99_RS14185	COG0431	NADPH-dependent FMN reductase
CLC99_RS14190	COG2188	Transcriptional regulator
CLC99_RS14195	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CLC99_RS14210	COG3964	amidohydrolase
CLC99_RS14230	COG1045	serine acetyltransferase
CLC99_RS14235	COG0626	cystathionine gamma-synthase activity
CLC99_RS14240	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CLC99_RS14270	COG2188	Transcriptional regulator
CLC99_RS14275	COG0366	Alpha amylase catalytic
CLC99_RS14280	COG2190	(PTS) system
CLC99_RS14280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLC99_RS14280	COG1263	PTS System
CLC99_RS14285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLC99_RS14285	COG2190	(PTS) system
CLC99_RS14285	COG1263	PTS System
CLC99_RS14295	COG0163	prenyltransferase activity
CLC99_RS14305	COG1959	2 iron, 2 sulfur cluster binding
CLC99_RS14310	COG1309	transcriptional regulator
CLC99_RS14315	COG1914	H( )-stimulated, divalent metal cation uptake system
CLC99_RS14335	COG2814	Major facilitator Superfamily
CLC99_RS14345	COG5002	protein histidine kinase activity
CLC99_RS14350	COG0745	RESPONSE REGULATOR receiver
CLC99_RS14360	COG1737	Transcriptional regulator
CLC99_RS14365	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CLC99_RS14385	COG0277	FAD linked oxidase domain protein
CLC99_RS14395	COG2357	RelA SpoT domain protein
CLC99_RS14405	COG1033	growth of symbiont in host cell
CLC99_RS14405	COG2409	Drug exporters of the RND superfamily
CLC99_RS14410	COG2818	Glycosylase
CLC99_RS14420	COG0577	efflux transmembrane transporter activity
CLC99_RS14425	COG1136	(ABC) transporter
CLC99_RS14440	COG0741	lytic transglycosylase activity
CLC99_RS14445	COG3942	CHAP domain
CLC99_RS14445	COG1388	LysM domain
CLC99_RS14475	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CLC99_RS14485	COG1846	Transcriptional regulator
CLC99_RS14490	COG1252	NADH dehydrogenase
CLC99_RS14530	COG3842	ATPase activity
CLC99_RS14560	COG1725	Transcriptional regulator
CLC99_RS14565	COG1131	(ABC) transporter
CLC99_RS14575	COG1454	alcohol dehydrogenase
CLC99_RS14575	COG1012	belongs to the aldehyde dehydrogenase family
CLC99_RS14615	COG1268	BioY protein
CLC99_RS14630	COG0436	Aminotransferase
CLC99_RS14640	COG1682	transport, permease protein
CLC99_RS14645	COG1134	teichoic acid transport
CLC99_RS14660	COG2814	Major facilitator Superfamily
CLC99_RS14665	COG0004	ammonium transporteR
CLC99_RS14685	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CLC99_RS14695	COG3759	membrane
CLC99_RS14700	COG1881	PFAM PEBP family protein
CLC99_RS14730	COG0300	oxidoreductase activity
CLC99_RS14750	COG1125	glycine betaine transport
CLC99_RS14760	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CLC99_RS14770	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CLC99_RS14835	COG0110	maltose O-acetyltransferase activity
CLC99_RS14845	COG0561	phosphatase activity
CLC99_RS14855	COG0561	phosphatase activity
CLC99_RS14860	COG1114	Component of the transport system for branched-chain amino acids
CLC99_RS14910	COG0463	Glycosyl transferase, family 2
CLC99_RS14935	COG3279	Response regulator of the LytR AlgR family
CLC99_RS14960	COG2274	protein secretion by the type I secretion system
CLC99_RS14995	COG3973	AAA domain
CLC99_RS15000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CLC99_RS15005	COG0180	Tryptophanyl-tRNA synthetase
CLC99_RS15010	COG2188	Transcriptional regulator
CLC99_RS15015	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CLC99_RS15030	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CLC99_RS15035	COG2723	6-phospho-beta-galactosidase activity
CLC99_RS15040	COG1940	carbohydrate kinase activity
CLC99_RS15050	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CLC99_RS15065	COG0248	Ppx GppA phosphatase
CLC99_RS15080	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CLC99_RS15085	COG1801	Protein of unknown function DUF72
CLC99_RS15095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLC99_RS15095	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLC99_RS15105	COG0084	hydrolase, TatD family'
CLC99_RS15110	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CLC99_RS15115	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CLC99_RS15120	COG4466	Protein conserved in bacteria
CLC99_RS15125	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CLC99_RS15130	COG1073	alpha beta
CLC99_RS15135	COG1121	(ABC) transporter
CLC99_RS15140	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CLC99_RS15140	COG1321	iron dependent repressor
CLC99_RS15165	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CLC99_RS15170	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CLC99_RS15180	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CLC99_RS15205	COG1078	dGTPase activity
CLC99_RS15210	COG0095	Lipoate-protein ligase
CLC99_RS15220	COG3343	RNA polymerase activity
CLC99_RS15225	COG0504	CTP synthase activity
CLC99_RS15230	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CLC99_RS15235	COG0814	amino acid
CLC99_RS15245	COG1760	l-serine dehydratase
CLC99_RS15250	COG1760	l-serine dehydratase
CLC99_RS15265	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CLC99_RS15270	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CLC99_RS15275	COG0254	rRNA binding
CLC99_RS15285	COG3764	Sortase (surface protein transpeptidase)
CLC99_RS15290	COG1704	LemA family
CLC99_RS15295	COG0501	Belongs to the peptidase M48B family
CLC99_RS15305	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CLC99_RS15325	COG0736	holo-[acyl-carrier-protein] synthase activity
CLC99_RS15330	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CLC99_RS15335	COG2337	Toxic component of a toxin-antitoxin (TA) module
CLC99_RS15340	COG3158	transport of potassium into the cell
CLC99_RS15360	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CLC99_RS15365	COG0505	Belongs to the CarA family
CLC99_RS15370	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CLC99_RS15375	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CLC99_RS15380	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CLC99_RS15385	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CLC99_RS15390	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CLC99_RS15405	COG2267	carboxylic ester hydrolase activity
CLC99_RS15420	COG0039	L-malate dehydrogenase activity
CLC99_RS15425	COG0193	aminoacyl-tRNA hydrolase activity
CLC99_RS15430	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CLC99_RS15435	COG2244	polysaccharide biosynthetic process
CLC99_RS15440	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CLC99_RS15450	COG1098	S1 RNA binding domain
CLC99_RS15455	COG0037	tRNA processing
CLC99_RS15470	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CLC99_RS15475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CLC99_RS15480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CLC99_RS15520	COG3104	oligopeptide transport
CLC99_RS15580	COG2188	Transcriptional regulator
CLC99_RS15590	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CLC99_RS15595	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CLC99_RS15610	COG2183	response to ionizing radiation
CLC99_RS15615	COG3091	SprT-like family
CLC99_RS15620	COG0460	homoserine dehydrogenase
CLC99_RS15625	COG0083	homoserine kinase activity
CLC99_RS15640	COG3409	Peptidoglycan-binding domain 1 protein
CLC99_RS15665	COG3715	PTS system
CLC99_RS15670	COG3716	PTS system mannose fructose sorbose family IID component
CLC99_RS15680	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CLC99_RS15680	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CLC99_RS15685	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLC99_RS15685	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLC99_RS15690	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLC99_RS15690	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLC99_RS15695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLC99_RS15705	COG0439	Biotin carboxylase
CLC99_RS15715	COG0825	malonyl-CoA metabolic process
CLC99_RS15720	COG1316	TRANSCRIPTIONal
CLC99_RS15730	COG0697	spore germination
CLC99_RS15735	COG0588	phosphoglycerate mutase activity
CLC99_RS15750	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CLC99_RS15760	COG0756	dUTP diphosphatase activity
CLC99_RS15785	COG4956	integral membrane protein (PIN domain superfamily)
CLC99_RS15790	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CLC99_RS15795	COG0215	cysteine-tRNA ligase activity
CLC99_RS15800	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CLC99_RS15805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CLC99_RS15820	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CLC99_RS15830	COG0250	Participates in transcription elongation, termination and antitermination
CLC99_RS15840	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CLC99_RS15845	COG0081	regulation of translation
CLC99_RS15850	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CLC99_RS15855	COG0222	ribosome binding
CLC99_RS15890	COG1396	sequence-specific DNA binding
CLC99_RS16085	COG5280	Phage tail tape measure protein TP901
CLC99_RS16085	COG3953	SLT domain
CLC99_RS16170	COG1611	Belongs to the LOG family
CLC99_RS16180	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CLC99_RS16185	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CLC99_RS16190	COG2813	Specifically methylates the guanine in position
CLC99_RS16205	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CLC99_RS16210	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CLC99_RS16215	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CLC99_RS16225	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CLC99_RS16230	COG3870	Protein conserved in bacteria
CLC99_RS16235	COG0470	DNA polymerase III
CLC99_RS16240	COG4467	Involved in initiation control of chromosome replication
CLC99_RS16255	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CLC99_RS16260	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CLC99_RS16265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CLC99_RS16270	COG3639	organic phosphonate transmembrane transporter activity
CLC99_RS16280	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CLC99_RS16290	COG1214	PFAM Peptidase M22, glycoprotease
CLC99_RS16295	COG0456	acetyltransferase
CLC99_RS16300	COG0456	acetyltransferase
CLC99_RS16305	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CLC99_RS16315	COG0488	(ABC) transporter
CLC99_RS16320	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CLC99_RS16330	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CLC99_RS16335	COG0459	protein refolding
CLC99_RS16340	COG0531	amino acid
CLC99_RS16345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CLC99_RS16350	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CLC99_RS16355	COG1739	Uncharacterized protein family UPF0029
CLC99_RS16360	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CLC99_RS16375	COG0653	protein targeting
CLC99_RS16390	COG0745	RESPONSE REGULATOR receiver
CLC99_RS16395	COG5002	protein histidine kinase activity
CLC99_RS16400	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CLC99_RS16405	COG0573	inorganic phosphate transmembrane transporter activity
CLC99_RS16410	COG0581	inorganic phosphate transmembrane transporter activity
CLC99_RS16415	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CLC99_RS16420	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CLC99_RS16425	COG0704	Plays a role in the regulation of phosphate uptake
CLC99_RS16435	COG1950	PFAM Membrane protein of
CLC99_RS16440	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CLC99_RS16445	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CLC99_RS16450	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CLC99_RS16455	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CLC99_RS16465	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLC99_RS16485	COG1215	transferase activity, transferring glycosyl groups
CLC99_RS16500	COG0492	ferredoxin-NADP+ reductase activity
CLC99_RS16505	COG2323	membrane
CLC99_RS16515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CLC99_RS16525	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLC99_RS16535	COG2814	Major facilitator Superfamily
CLC99_RS16545	COG0556	nucleotide-excision repair
CLC99_RS16550	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CLC99_RS16555	COG1854	S-ribosylhomocysteine lyase activity
CLC99_RS16560	COG0137	argininosuccinate synthase activity
CLC99_RS16565	COG0165	Argininosuccinate lyase
CLC99_RS16575	COG1660	Displays ATPase and GTPase activities
CLC99_RS16585	COG1481	regulation of sporulation
CLC99_RS16590	COG4166	transmembrane transport
CLC99_RS16595	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CLC99_RS16600	COG0740	serine-type endopeptidase activity
CLC99_RS16610	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CLC99_RS16615	COG2390	Transcriptional regulator
CLC99_RS16625	COG0126	phosphoglycerate kinase activity
CLC99_RS16630	COG0149	triose-phosphate isomerase activity
CLC99_RS16635	COG0148	phosphopyruvate hydratase activity
CLC99_RS16650	COG0038	chloride channel
CLC99_RS16655	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CLC99_RS16665	COG0557	exoribonuclease II activity
CLC99_RS16670	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CLC99_RS16680	COG0765	amino acid transport
CLC99_RS16685	COG1126	abc transporter atp-binding protein
CLC99_RS16695	COG0561	phosphatase activity
CLC99_RS16700	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CLC99_RS16705	COG0280	phosphate acetyltransferase
CLC99_RS16710	COG0802	atpase or kinase
CLC99_RS16725	COG0708	Exodeoxyribonuclease III
CLC99_RS16735	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CLC99_RS16740	COG0025	NhaP-type Na H and K H
CLC99_RS16765	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CLC99_RS16770	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CLC99_RS16780	COG0561	phosphatase activity
CLC99_RS16790	COG2017	converts alpha-aldose to the beta-anomer
CLC99_RS16805	COG0778	Nitroreductase
CLC99_RS16830	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CLC99_RS16845	COG1393	Belongs to the ArsC family
CLC99_RS16860	COG0477	Major facilitator Superfamily
CLC99_RS16870	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CLC99_RS16880	COG3475	LICD family
CLC99_RS16895	COG2252	PERMEase
CLC99_RS16905	COG1346	cytolysis
CLC99_RS16915	COG3279	Response regulator of the LytR AlgR family
CLC99_RS16920	COG3275	phosphorelay sensor kinase activity
CLC99_RS16940	COG1464	Belongs to the NlpA lipoprotein family
CLC99_RS16945	COG2011	ABC-type metal ion transport system permease component
CLC99_RS16950	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CLC99_RS16955	COG1956	GAF domain-containing protein
CLC99_RS16965	COG1113	amino acid transport
CLC99_RS17035	COG1192	Involved in chromosome partitioning
CLC99_RS17070	COG3716	PTS system mannose fructose sorbose family IID component
CLC99_RS17100	COG3328	transposase activity
CLC99_RS17115	COG3716	PTS system mannose fructose sorbose family IID component
CLC99_RS17180	COG0477	Major facilitator Superfamily
CLC99_RS17185	COG1418	mRNA catabolic process
CLC99_RS17290	COG1192	Involved in chromosome partitioning
CLC99_RS17305	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CLC99_RS17350	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CLC99_RS17355	COG3158	transport of potassium into the cell
CLC99_RS17430	COG0542	response to heat
CLC99_RS17570	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CLC99_RS17595	COG3158	transport of potassium into the cell
CLC99_RS17650	COG2261	transglycosylase associated protein
CLC99_RS17665	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CLC99_RS17680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family