locus-tag	class	description
HPB53_RS00015	COG1757	Na H antiporter
HPB53_RS00020	COG1113	amino acid transport
HPB53_RS00030	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HPB53_RS00045	COG1393	Belongs to the ArsC family
HPB53_RS00050	COG3189	MarR family transcriptional regulator
HPB53_RS00060	COG1194	a g-specific adenine glycosylase
HPB53_RS00075	COG0071	Belongs to the small heat shock protein (HSP20) family
HPB53_RS00100	COG0697	spore germination
HPB53_RS00115	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HPB53_RS00140	COG0477	Major facilitator Superfamily
HPB53_RS00195	COG0737	Belongs to the 5'-nucleotidase family
HPB53_RS00205	COG0656	L-ascorbic acid biosynthetic process
HPB53_RS00225	COG1968	undecaprenyl-diphosphatase activity
HPB53_RS00230	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HPB53_RS00265	COG2207	Transcriptional regulator
HPB53_RS00290	COG0076	glutamate decarboxylase activity
HPB53_RS00330	COG1309	transcriptional regulator
HPB53_RS00340	COG2226	methyltransferase
HPB53_RS00355	COG2217	Heavy metal translocating P-type atpase
HPB53_RS00360	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HPB53_RS00365	COG3118	belongs to the thioredoxin family
HPB53_RS00370	COG1937	Protein conserved in bacteria
HPB53_RS00390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPB53_RS00395	COG3590	peptidase
HPB53_RS00410	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPB53_RS00470	COG1114	Component of the transport system for branched-chain amino acids
HPB53_RS00480	COG1874	Beta-galactosidase
HPB53_RS00485	COG1609	Transcriptional regulator
HPB53_RS00495	COG0477	Major facilitator Superfamily
HPB53_RS00515	COG2184	nucleotidyltransferase activity
HPB53_RS00520	COG2944	sequence-specific DNA binding
HPB53_RS00525	COG1609	Transcriptional regulator
HPB53_RS00530	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HPB53_RS00535	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPB53_RS00540	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HPB53_RS00560	COG2211	Major facilitator Superfamily
HPB53_RS00560	COG2190	(PTS) system
HPB53_RS00565	COG2017	converts alpha-aldose to the beta-anomer
HPB53_RS00570	COG1609	Transcriptional regulator
HPB53_RS00575	COG0667	Aldo Keto reductase
HPB53_RS00595	COG0710	3-dehydroquinate dehydratase activity
HPB53_RS00600	COG0738	Major facilitator superfamily
HPB53_RS00605	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPB53_RS00610	COG0583	DNA-binding transcription factor activity
HPB53_RS00615	COG0738	Major facilitator superfamily
HPB53_RS00625	COG2267	carboxylic ester hydrolase activity
HPB53_RS00630	COG2188	Transcriptional regulator
HPB53_RS00635	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPB53_RS00640	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPB53_RS00645	COG2971	BadF BadG BcrA BcrD
HPB53_RS00655	COG2723	6-phospho-beta-galactosidase activity
HPB53_RS00665	COG3711	transcriptional antiterminator
HPB53_RS00670	COG2723	6-phospho-beta-galactosidase activity
HPB53_RS00675	COG2723	6-phospho-beta-galactosidase activity
HPB53_RS00680	COG2190	(PTS) system
HPB53_RS00680	COG1263	PTS System
HPB53_RS00680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPB53_RS00700	COG2211	Major facilitator Superfamily
HPB53_RS00715	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HPB53_RS00730	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HPB53_RS00750	COG3711	transcriptional antiterminator
HPB53_RS00765	COG3775	system Galactitol-specific IIC component
HPB53_RS00770	COG3414	Phosphotransferase system galactitol-specific IIB component
HPB53_RS00780	COG1349	DNA-binding transcription factor activity
HPB53_RS00785	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HPB53_RS00795	COG0110	maltose O-acetyltransferase activity
HPB53_RS00800	COG2160	L-arabinose isomerase activity
HPB53_RS00820	COG1609	Transcriptional regulator
HPB53_RS00825	COG1737	Transcriptional regulator
HPB53_RS00845	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPB53_RS00865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPB53_RS00870	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HPB53_RS00890	COG2261	transglycosylase associated protein
HPB53_RS00900	COG1393	Belongs to the ArsC family
HPB53_RS00920	COG4512	PFAM Accessory gene regulator B
HPB53_RS00935	COG1304	FMN binding
HPB53_RS00940	COG0028	Belongs to the TPP enzyme family
HPB53_RS00945	COG1959	2 iron, 2 sulfur cluster binding
HPB53_RS00950	COG0028	Belongs to the TPP enzyme family
HPB53_RS00965	COG0235	Class ii aldolase
HPB53_RS00970	COG4806	L-rhamnose isomerase
HPB53_RS00975	COG3254	rhamnose metabolic process
HPB53_RS00980	COG1070	Carbohydrate kinase
HPB53_RS00985	COG2814	Major facilitator Superfamily
HPB53_RS00990	COG2207	Transcriptional regulator
HPB53_RS00995	COG1349	DNA-binding transcription factor activity
HPB53_RS01010	COG3775	system Galactitol-specific IIC component
HPB53_RS01020	COG1263	PTS System
HPB53_RS01020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPB53_RS01020	COG2190	(PTS) system
HPB53_RS01040	COG1737	Transcriptional regulator
HPB53_RS01045	COG1263	PTS System
HPB53_RS01045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPB53_RS01065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPB53_RS01065	COG1263	PTS System
HPB53_RS01075	COG1609	Transcriptional regulator
HPB53_RS01085	COG0366	Alpha amylase catalytic
HPB53_RS01090	COG2723	6-phospho-beta-galactosidase activity
HPB53_RS01095	COG1940	carbohydrate kinase activity
HPB53_RS01100	COG0383	alpha-mannosidase activity
HPB53_RS01110	COG2188	Transcriptional regulator
HPB53_RS01120	COG3842	ATPase activity
HPB53_RS01130	COG4753	response regulator
HPB53_RS01130	COG2207	Transcriptional regulator
HPB53_RS01135	COG2972	Histidine kinase
HPB53_RS01145	COG0366	Alpha amylase catalytic
HPB53_RS01150	COG1653	transport
HPB53_RS01155	COG0395	ABC-type sugar transport system, permease component
HPB53_RS01170	COG2207	Transcriptional regulator
HPB53_RS01170	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPB53_RS01180	COG1132	(ABC) transporter
HPB53_RS01185	COG2188	Transcriptional regulator
HPB53_RS01200	COG3732	PTS system glucitol sorbitol-specific
HPB53_RS01205	COG3730	PTS system glucitol sorbitol-specific
HPB53_RS01225	COG4975	Glucose uptake
HPB53_RS01230	COG1869	D-ribose catabolic process
HPB53_RS01240	COG1609	Transcriptional regulator
HPB53_RS01245	COG1012	belongs to the aldehyde dehydrogenase family
HPB53_RS01245	COG1454	alcohol dehydrogenase
HPB53_RS01255	COG1695	Transcriptional regulator
HPB53_RS01260	COG3479	Phenolic acid decarboxylase
HPB53_RS01275	COG1307	EDD domain protein, DegV family
HPB53_RS01315	COG0445	tRNA wobble uridine modification
HPB53_RS01320	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HPB53_RS01325	COG1847	R3H domain protein
HPB53_RS01335	COG4166	transmembrane transport
HPB53_RS01340	COG0706	membrane insertase activity
HPB53_RS01345	COG0594	ribonuclease P activity
HPB53_RS01350	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HPB53_RS01355	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HPB53_RS01360	COG0592	DNA-directed DNA polymerase activity
HPB53_RS01365	COG2501	S4 domain
HPB53_RS01370	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HPB53_RS01375	COG0187	DNA topoisomerase II activity
HPB53_RS01385	COG0360	Binds together with S18 to 16S ribosomal RNA
HPB53_RS01390	COG0629	single-stranded DNA binding
HPB53_RS01395	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HPB53_RS01405	COG0359	binds to the 23S rRNA
HPB53_RS01410	COG0305	Participates in initiation and elongation during chromosome replication
HPB53_RS01415	COG2814	Major facilitator Superfamily
HPB53_RS01420	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HPB53_RS01425	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HPB53_RS01430	COG4166	transmembrane transport
HPB53_RS01440	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPB53_RS01445	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPB53_RS01450	COG0297	glycogen (starch) synthase activity
HPB53_RS01455	COG0058	SHG alpha-glucan phosphorylase activity
HPB53_RS01460	COG0366	Alpha amylase catalytic
HPB53_RS01460	COG3103	Sh3 type 3 domain protein
HPB53_RS01470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPB53_RS01475	COG1554	hydrolase, family 65, central catalytic
HPB53_RS01485	COG1278	Cold shock
HPB53_RS01500	COG0745	RESPONSE REGULATOR receiver
HPB53_RS01505	COG5002	protein histidine kinase activity
HPB53_RS01515	COG4853	Protein conserved in bacteria
HPB53_RS01520	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HPB53_RS01525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPB53_RS01530	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HPB53_RS01540	COG1012	belongs to the aldehyde dehydrogenase family
HPB53_RS01545	COG1573	uracil-dna glycosylase
HPB53_RS01570	COG3976	FMN-binding domain protein
HPB53_RS01570	COG1053	succinate dehydrogenase
HPB53_RS01570	COG0431	NADPH-dependent FMN reductase
HPB53_RS01575	COG0471	metal ion transport
HPB53_RS01590	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPB53_RS01595	COG1028	Short-chain dehydrogenase reductase Sdr
HPB53_RS01605	COG0778	Nitroreductase
HPB53_RS01610	COG2508	Transcriptional regulator
HPB53_RS01615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPB53_RS01620	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HPB53_RS01630	COG2365	Tyrosine phosphatase family
HPB53_RS01635	COG2368	4-hydroxyphenylacetate
HPB53_RS01655	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HPB53_RS01685	COG0604	alcohol dehydrogenase
HPB53_RS01705	COG2267	carboxylic ester hydrolase activity
HPB53_RS01710	COG3022	response to hydroperoxide
HPB53_RS01720	COG4166	transmembrane transport
HPB53_RS01745	COG1122	ATPase activity
HPB53_RS01750	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HPB53_RS01755	COG0310	cobalt ion transport
HPB53_RS01760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPB53_RS01765	COG3875	lactate racemase activity
HPB53_RS01770	COG1691	(AIR) carboxylase
HPB53_RS01775	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HPB53_RS01780	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HPB53_RS01785	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HPB53_RS01790	COG1606	tRNA processing
HPB53_RS01795	COG0604	alcohol dehydrogenase
HPB53_RS01800	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HPB53_RS01805	COG0351	phosphomethylpyrimidine kinase
HPB53_RS01810	COG0352	thiamine-phosphate diphosphorylase activity
HPB53_RS01820	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HPB53_RS01835	COG1113	amino acid transport
HPB53_RS01845	COG2267	carboxylic ester hydrolase activity
HPB53_RS01850	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HPB53_RS01855	COG1983	PspC domain protein
HPB53_RS01895	COG2807	transmembrane transport
HPB53_RS01900	COG0656	L-ascorbic acid biosynthetic process
HPB53_RS01905	COG0667	Aldo Keto reductase
HPB53_RS01935	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HPB53_RS01940	COG1122	ATPase activity
HPB53_RS01945	COG4720	Psort location CytoplasmicMembrane, score
HPB53_RS01955	COG2188	Transcriptional regulator
HPB53_RS01980	COG1028	Short-chain dehydrogenase reductase Sdr
HPB53_RS01985	COG1131	(ABC) transporter
HPB53_RS02000	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HPB53_RS02005	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HPB53_RS02010	COG1309	transcriptional regulator
HPB53_RS02015	COG2376	Dihydroxyacetone kinase
HPB53_RS02020	COG2376	Dihydroxyacetone kinase
HPB53_RS02025	COG1461	Dihydroxyacetone kinase
HPB53_RS02030	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HPB53_RS02035	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HPB53_RS02040	COG1609	Transcriptional regulator
HPB53_RS02045	COG1609	Transcriptional regulator
HPB53_RS02050	COG0366	Alpha amylase catalytic
HPB53_RS02055	COG2182	Extracellular solute-binding protein
HPB53_RS02060	COG1175	transmembrane transport
HPB53_RS02065	COG3833	ABC-type maltose transport systems, permease component
HPB53_RS02075	COG0366	Alpha amylase catalytic
HPB53_RS02080	COG3842	ATPase activity
HPB53_RS02130	COG1757	Na H antiporter
HPB53_RS02155	COG4166	transmembrane transport
HPB53_RS02160	COG4166	transmembrane transport
HPB53_RS02170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPB53_RS02175	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HPB53_RS02180	COG0406	alpha-ribazole phosphatase activity
HPB53_RS02185	COG0667	Aldo Keto reductase
HPB53_RS02215	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPB53_RS02220	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPB53_RS02225	COG0488	(ABC) transporter
HPB53_RS02240	COG4172	Belongs to the ABC transporter superfamily
HPB53_RS02250	COG0386	Belongs to the glutathione peroxidase family
HPB53_RS02260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPB53_RS02275	COG0363	glucosamine-6-phosphate deaminase activity
HPB53_RS02285	COG3976	FMN-binding domain protein
HPB53_RS02285	COG1053	succinate dehydrogenase
HPB53_RS02300	COG2213	PTS system mannitol-specific
HPB53_RS02310	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPB53_RS02315	COG0246	Mannitol dehydrogenase
HPB53_RS02325	COG3118	belongs to the thioredoxin family
HPB53_RS02355	COG0431	NADPH-dependent FMN reductase
HPB53_RS02360	COG1045	serine acetyltransferase
HPB53_RS02365	COG0626	cystathionine gamma-synthase activity
HPB53_RS02370	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPB53_RS02395	COG2188	Transcriptional regulator
HPB53_RS02400	COG0366	Alpha amylase catalytic
HPB53_RS02405	COG1263	PTS System
HPB53_RS02405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPB53_RS02405	COG2190	(PTS) system
HPB53_RS02410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPB53_RS02410	COG2190	(PTS) system
HPB53_RS02410	COG1263	PTS System
HPB53_RS02420	COG0163	prenyltransferase activity
HPB53_RS02430	COG1959	2 iron, 2 sulfur cluster binding
HPB53_RS02435	COG1309	transcriptional regulator
HPB53_RS02440	COG1914	H( )-stimulated, divalent metal cation uptake system
HPB53_RS02460	COG2814	Major facilitator Superfamily
HPB53_RS02470	COG5002	protein histidine kinase activity
HPB53_RS02475	COG0745	RESPONSE REGULATOR receiver
HPB53_RS02485	COG1737	Transcriptional regulator
HPB53_RS02490	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPB53_RS02505	COG1316	TRANSCRIPTIONal
HPB53_RS02510	COG0277	FAD linked oxidase domain protein
HPB53_RS02520	COG2357	RelA SpoT domain protein
HPB53_RS02530	COG2409	Drug exporters of the RND superfamily
HPB53_RS02530	COG1033	growth of symbiont in host cell
HPB53_RS02535	COG2818	Glycosylase
HPB53_RS02545	COG0577	efflux transmembrane transporter activity
HPB53_RS02550	COG1136	(ABC) transporter
HPB53_RS02565	COG0741	lytic transglycosylase activity
HPB53_RS02570	COG3942	CHAP domain
HPB53_RS02570	COG1388	LysM domain
HPB53_RS02600	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPB53_RS02610	COG1846	Transcriptional regulator
HPB53_RS02615	COG1252	NADH dehydrogenase
HPB53_RS02655	COG3842	ATPase activity
HPB53_RS02685	COG1725	Transcriptional regulator
HPB53_RS02690	COG1131	(ABC) transporter
HPB53_RS02700	COG1012	belongs to the aldehyde dehydrogenase family
HPB53_RS02700	COG1454	alcohol dehydrogenase
HPB53_RS02735	COG1268	BioY protein
HPB53_RS02765	COG2011	ABC-type metal ion transport system permease component
HPB53_RS02770	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPB53_RS02775	COG0436	Aminotransferase
HPB53_RS02785	COG1682	transport, permease protein
HPB53_RS02790	COG1134	teichoic acid transport
HPB53_RS02805	COG2814	Major facilitator Superfamily
HPB53_RS02810	COG0004	ammonium transporteR
HPB53_RS02830	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HPB53_RS02840	COG3759	membrane
HPB53_RS02845	COG1881	PFAM PEBP family protein
HPB53_RS02875	COG0300	oxidoreductase activity
HPB53_RS02890	COG1125	glycine betaine transport
HPB53_RS02900	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HPB53_RS02910	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HPB53_RS02975	COG0110	maltose O-acetyltransferase activity
HPB53_RS02985	COG0561	phosphatase activity
HPB53_RS02995	COG0561	phosphatase activity
HPB53_RS03000	COG1114	Component of the transport system for branched-chain amino acids
HPB53_RS03040	COG0463	Glycosyl transferase, family 2
HPB53_RS03065	COG3279	Response regulator of the LytR AlgR family
HPB53_RS03130	COG3973	AAA domain
HPB53_RS03135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPB53_RS03140	COG0180	Tryptophanyl-tRNA synthetase
HPB53_RS03145	COG2188	Transcriptional regulator
HPB53_RS03150	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPB53_RS03165	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPB53_RS03170	COG2723	6-phospho-beta-galactosidase activity
HPB53_RS03175	COG1940	carbohydrate kinase activity
HPB53_RS03185	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPB53_RS03200	COG0248	Ppx GppA phosphatase
HPB53_RS03215	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPB53_RS03220	COG1801	Protein of unknown function DUF72
HPB53_RS03230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPB53_RS03230	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPB53_RS03235	COG2814	Major facilitator Superfamily
HPB53_RS03240	COG0084	hydrolase, TatD family'
HPB53_RS03245	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HPB53_RS03250	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HPB53_RS03255	COG4466	Protein conserved in bacteria
HPB53_RS03260	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HPB53_RS03265	COG1073	alpha beta
HPB53_RS03270	COG1121	(ABC) transporter
HPB53_RS03275	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPB53_RS03275	COG1321	iron dependent repressor
HPB53_RS03300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPB53_RS03305	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPB53_RS03315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HPB53_RS03335	COG1078	dGTPase activity
HPB53_RS03340	COG0095	Lipoate-protein ligase
HPB53_RS03350	COG3343	RNA polymerase activity
HPB53_RS03355	COG0504	CTP synthase activity
HPB53_RS03360	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HPB53_RS03365	COG0814	amino acid
HPB53_RS03370	COG1760	l-serine dehydratase
HPB53_RS03375	COG1760	l-serine dehydratase
HPB53_RS03390	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HPB53_RS03395	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HPB53_RS03400	COG0254	rRNA binding
HPB53_RS03410	COG3764	Sortase (surface protein transpeptidase)
HPB53_RS03415	COG1704	LemA family
HPB53_RS03420	COG0501	Belongs to the peptidase M48B family
HPB53_RS03430	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPB53_RS03440	COG0736	holo-[acyl-carrier-protein] synthase activity
HPB53_RS03445	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPB53_RS03450	COG2337	Toxic component of a toxin-antitoxin (TA) module
HPB53_RS03455	COG3158	transport of potassium into the cell
HPB53_RS03475	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPB53_RS03480	COG0505	Belongs to the CarA family
HPB53_RS03485	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HPB53_RS03490	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HPB53_RS03495	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPB53_RS03500	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPB53_RS03505	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HPB53_RS03525	COG0039	L-malate dehydrogenase activity
HPB53_RS03530	COG0193	aminoacyl-tRNA hydrolase activity
HPB53_RS03535	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPB53_RS03540	COG2244	polysaccharide biosynthetic process
HPB53_RS03545	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HPB53_RS03555	COG1098	S1 RNA binding domain
HPB53_RS03560	COG0037	tRNA processing
HPB53_RS03575	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HPB53_RS03580	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPB53_RS03585	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HPB53_RS03605	COG3104	oligopeptide transport
HPB53_RS03655	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPB53_RS03665	COG2188	Transcriptional regulator
HPB53_RS03675	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HPB53_RS03680	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HPB53_RS03695	COG2183	response to ionizing radiation
HPB53_RS03700	COG3091	SprT-like family
HPB53_RS03705	COG0460	homoserine dehydrogenase
HPB53_RS03710	COG0083	homoserine kinase activity
HPB53_RS03730	COG3715	PTS system
HPB53_RS03735	COG3716	PTS system mannose fructose sorbose family IID component
HPB53_RS03745	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HPB53_RS03745	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HPB53_RS03750	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPB53_RS03750	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPB53_RS03755	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPB53_RS03755	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPB53_RS03760	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPB53_RS03770	COG0439	Biotin carboxylase
HPB53_RS03780	COG0825	malonyl-CoA metabolic process
HPB53_RS03785	COG1316	TRANSCRIPTIONal
HPB53_RS03795	COG0697	spore germination
HPB53_RS03800	COG0588	phosphoglycerate mutase activity
HPB53_RS03815	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HPB53_RS03825	COG0756	dUTP diphosphatase activity
HPB53_RS03835	COG4956	integral membrane protein (PIN domain superfamily)
HPB53_RS03840	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPB53_RS03845	COG0215	cysteine-tRNA ligase activity
HPB53_RS03850	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HPB53_RS03855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPB53_RS03870	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HPB53_RS03880	COG0250	Participates in transcription elongation, termination and antitermination
HPB53_RS03890	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HPB53_RS03895	COG0081	regulation of translation
HPB53_RS03900	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HPB53_RS03905	COG0222	ribosome binding
HPB53_RS03945	COG1396	sequence-specific DNA binding
HPB53_RS03990	COG3935	DnaD domain protein
HPB53_RS04185	COG3177	Filamentation induced by cAMP protein fic
HPB53_RS04205	COG1611	Belongs to the LOG family
HPB53_RS04215	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPB53_RS04220	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPB53_RS04225	COG2813	Specifically methylates the guanine in position
HPB53_RS04240	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HPB53_RS04245	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HPB53_RS04250	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HPB53_RS04260	COG3711	transcriptional antiterminator
HPB53_RS04285	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HPB53_RS04290	COG3870	Protein conserved in bacteria
HPB53_RS04295	COG0470	DNA polymerase III
HPB53_RS04300	COG4467	Involved in initiation control of chromosome replication
HPB53_RS04315	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPB53_RS04320	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPB53_RS04330	COG3639	organic phosphonate transmembrane transporter activity
HPB53_RS04340	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HPB53_RS04350	COG1214	PFAM Peptidase M22, glycoprotease
HPB53_RS04355	COG0456	acetyltransferase
HPB53_RS04360	COG0456	acetyltransferase
HPB53_RS04365	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HPB53_RS04370	COG0488	(ABC) transporter
HPB53_RS04375	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HPB53_RS04385	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPB53_RS04390	COG0459	protein refolding
HPB53_RS04395	COG0531	amino acid
HPB53_RS04400	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPB53_RS04405	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPB53_RS04410	COG1739	Uncharacterized protein family UPF0029
HPB53_RS04415	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HPB53_RS04430	COG0653	protein targeting
HPB53_RS04445	COG0745	RESPONSE REGULATOR receiver
HPB53_RS04450	COG5002	protein histidine kinase activity
HPB53_RS04455	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPB53_RS04460	COG0573	inorganic phosphate transmembrane transporter activity
HPB53_RS04465	COG0581	inorganic phosphate transmembrane transporter activity
HPB53_RS04470	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPB53_RS04475	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPB53_RS04480	COG0704	Plays a role in the regulation of phosphate uptake
HPB53_RS04485	COG1983	PspC domain protein
HPB53_RS04490	COG1950	PFAM Membrane protein of
HPB53_RS04495	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HPB53_RS04500	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HPB53_RS04505	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HPB53_RS04510	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HPB53_RS04520	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPB53_RS04540	COG1215	transferase activity, transferring glycosyl groups
HPB53_RS04555	COG0492	ferredoxin-NADP+ reductase activity
HPB53_RS04560	COG2323	membrane
HPB53_RS04570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPB53_RS04580	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPB53_RS04590	COG2814	Major facilitator Superfamily
HPB53_RS04600	COG0556	nucleotide-excision repair
HPB53_RS04605	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPB53_RS04610	COG1854	S-ribosylhomocysteine lyase activity
HPB53_RS04615	COG0137	argininosuccinate synthase activity
HPB53_RS04620	COG0165	Argininosuccinate lyase
HPB53_RS04630	COG1660	Displays ATPase and GTPase activities
HPB53_RS04640	COG1481	regulation of sporulation
HPB53_RS04650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPB53_RS04655	COG0740	serine-type endopeptidase activity
HPB53_RS04665	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HPB53_RS04670	COG2390	Transcriptional regulator
HPB53_RS04680	COG0126	phosphoglycerate kinase activity
HPB53_RS04685	COG0149	triose-phosphate isomerase activity
HPB53_RS04690	COG0148	phosphopyruvate hydratase activity
HPB53_RS04700	COG0038	chloride channel
HPB53_RS04705	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPB53_RS04715	COG0557	exoribonuclease II activity
HPB53_RS04720	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HPB53_RS04730	COG0765	amino acid transport
HPB53_RS04735	COG1126	abc transporter atp-binding protein
HPB53_RS04745	COG0561	phosphatase activity
HPB53_RS04750	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HPB53_RS04755	COG0280	phosphate acetyltransferase
HPB53_RS04760	COG0802	atpase or kinase
HPB53_RS04775	COG0708	Exodeoxyribonuclease III
HPB53_RS04785	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HPB53_RS04790	COG0025	NhaP-type Na H and K H
HPB53_RS04815	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPB53_RS04820	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HPB53_RS04830	COG0561	phosphatase activity
HPB53_RS04840	COG2017	converts alpha-aldose to the beta-anomer
HPB53_RS04855	COG0778	Nitroreductase
HPB53_RS04870	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HPB53_RS04885	COG1393	Belongs to the ArsC family
HPB53_RS04900	COG0477	Major facilitator Superfamily
HPB53_RS04905	COG0248	Ppx GppA phosphatase
HPB53_RS04905	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HPB53_RS04910	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HPB53_RS04920	COG3475	LICD family
HPB53_RS04935	COG2252	PERMEase
HPB53_RS04940	COG0028	Belongs to the TPP enzyme family
HPB53_RS04945	COG0196	riboflavin kinase activity
HPB53_RS04950	COG0028	Belongs to the TPP enzyme family
HPB53_RS04955	COG2267	carboxylic ester hydrolase activity
HPB53_RS04965	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HPB53_RS04965	COG2755	lipolytic protein G-D-S-L family
HPB53_RS04970	COG2936	dipeptidyl-peptidase activity
HPB53_RS04985	COG0531	amino acid
HPB53_RS05010	COG0194	GDP metabolic process
HPB53_RS05015	COG0735	belongs to the Fur family
HPB53_RS05030	COG0546	phosphoglycolate phosphatase activity
HPB53_RS05035	COG0436	Aminotransferase
HPB53_RS05040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPB53_RS05060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPB53_RS05065	COG0765	amino acid transport
HPB53_RS05070	COG0765	amino acid transport
HPB53_RS05075	COG1263	PTS System
HPB53_RS05075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPB53_RS05075	COG2190	(PTS) system
HPB53_RS05085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPB53_RS05085	COG1263	PTS System
HPB53_RS05090	COG3394	polysaccharide catabolic process
HPB53_RS05095	COG0531	amino acid
HPB53_RS05100	COG1846	Transcriptional regulator
HPB53_RS05130	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPB53_RS05140	COG2076	Multidrug Resistance protein
HPB53_RS05155	COG0588	phosphoglycerate mutase activity
HPB53_RS05160	COG0475	glutathione-regulated potassium exporter activity
HPB53_RS05160	COG0569	domain protein
HPB53_RS05165	COG0456	acetyltransferase
HPB53_RS05165	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPB53_RS05170	COG0586	Pfam SNARE associated Golgi protein
HPB53_RS05175	COG3973	AAA domain
HPB53_RS05180	COG2070	2-Nitropropane dioxygenase
HPB53_RS05185	COG1072	(Pantothenic acid kinase))
HPB53_RS05190	COG0519	Catalyzes the synthesis of GMP from XMP
HPB53_RS05190	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HPB53_RS05200	COG1396	sequence-specific DNA binding
HPB53_RS05210	COG1266	CAAX protease self-immunity
HPB53_RS05225	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HPB53_RS05225	COG2755	lipolytic protein G-D-S-L family
HPB53_RS05230	COG2261	transglycosylase associated protein
HPB53_RS05245	COG1302	Protein conserved in bacteria
HPB53_RS05275	COG0308	aminopeptidase N
HPB53_RS05305	COG0572	uridine kinase
HPB53_RS05320	COG0583	DNA-binding transcription factor activity
HPB53_RS05325	COG1053	succinate dehydrogenase
HPB53_RS05335	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HPB53_RS05340	COG0017	Asparaginyl-tRNA synthetase
HPB53_RS05345	COG2502	aspartate--ammonia ligase
HPB53_RS05350	COG4690	dipeptidase activity
HPB53_RS05370	COG0514	ATP-dependent DNA helicase (RecQ)
HPB53_RS05375	COG0564	pseudouridine synthase activity
HPB53_RS05380	COG0640	Transcriptional regulator
HPB53_RS05430	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPB53_RS05435	COG0527	aspartate kinase activity
HPB53_RS05440	COG0367	asparagine synthase
HPB53_RS05470	COG2814	Major facilitator Superfamily
HPB53_RS05490	COG1278	Cold shock
HPB53_RS05495	COG2966	Psort location CytoplasmicMembrane, score
HPB53_RS05505	COG1316	TRANSCRIPTIONal
HPB53_RS05525	COG1959	2 iron, 2 sulfur cluster binding
HPB53_RS05530	COG0028	Belongs to the TPP enzyme family
HPB53_RS05535	COG0833	amino acid
HPB53_RS05545	COG1428	Deoxynucleoside kinase
HPB53_RS05550	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HPB53_RS05590	COG4463	regulation of RNA biosynthetic process
HPB53_RS05595	COG0542	response to heat
HPB53_RS05605	COG0085	RNA polymerase activity
HPB53_RS05610	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HPB53_RS05615	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HPB53_RS05620	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HPB53_RS05625	COG0049	tRNA binding
HPB53_RS05630	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPB53_RS05635	COG0051	transcription antitermination factor activity, RNA binding
HPB53_RS05640	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HPB53_RS05645	COG0088	Forms part of the polypeptide exit tunnel
HPB53_RS05650	COG0089	rRNA binding
HPB53_RS05655	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HPB53_RS05660	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HPB53_RS05665	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HPB53_RS05670	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HPB53_RS05675	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HPB53_RS05680	COG0255	Belongs to the universal ribosomal protein uL29 family
HPB53_RS05685	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HPB53_RS05690	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HPB53_RS05695	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HPB53_RS05700	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPB53_RS05705	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HPB53_RS05710	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HPB53_RS05715	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HPB53_RS05720	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HPB53_RS05725	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HPB53_RS05730	COG1841	ribosomal large subunit assembly
HPB53_RS05735	COG0200	Binds to the 23S rRNA
HPB53_RS05745	COG0563	adenylate kinase activity
HPB53_RS05750	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPB53_RS05755	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPB53_RS05760	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HPB53_RS05765	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HPB53_RS05770	COG0202	RNA polymerase activity
HPB53_RS05775	COG0203	ribosomal protein L17
HPB53_RS05800	COG4939	FMN-binding domain protein
HPB53_RS05810	COG1122	ATPase activity
HPB53_RS05815	COG1122	ATPase activity
HPB53_RS05825	COG0101	tRNA pseudouridine synthase activity
HPB53_RS05830	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HPB53_RS05835	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HPB53_RS05855	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPB53_RS05860	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPB53_RS05865	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HPB53_RS05870	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HPB53_RS05875	COG0471	metal ion transport
HPB53_RS05880	COG2151	metal-sulfur cluster biosynthetic enzyme
HPB53_RS05885	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HPB53_RS05895	COG4977	sequence-specific DNA binding
HPB53_RS05895	COG1917	Cupin 2, conserved barrel domain protein
HPB53_RS05900	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HPB53_RS05905	COG1121	(ABC) transporter
HPB53_RS05910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPB53_RS05915	COG0803	Belongs to the bacterial solute-binding protein 9 family
HPB53_RS05925	COG0039	L-malate dehydrogenase activity
HPB53_RS05930	COG0471	metal ion transport
HPB53_RS05950	COG3052	prosthetic group binding
HPB53_RS05985	COG0114	fumarate hydratase activity
HPB53_RS05990	COG1053	succinate dehydrogenase
HPB53_RS06000	COG0583	DNA-binding transcription factor activity
HPB53_RS06005	COG0583	DNA-binding transcription factor activity
HPB53_RS06010	COG0281	malic enzyme
HPB53_RS06020	COG0531	amino acid
HPB53_RS06025	COG4684	Psort location CytoplasmicMembrane, score
HPB53_RS06040	COG1271	oxidase subunit
HPB53_RS06045	COG1294	oxidase, subunit
HPB53_RS06050	COG4988	ABC transporter
HPB53_RS06055	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HPB53_RS06070	COG0142	geranyltranstransferase activity
HPB53_RS06085	COG1705	Flagellar rod assembly protein muramidase FlgJ
HPB53_RS06090	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPB53_RS06095	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HPB53_RS06100	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HPB53_RS06110	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPB53_RS06115	COG4851	CamS sex pheromone cAM373 precursor
HPB53_RS06120	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HPB53_RS06125	COG0154	amidase activity
HPB53_RS06130	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HPB53_RS06135	COG1597	lipid kinase activity
HPB53_RS06140	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPB53_RS06155	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPB53_RS06165	COG1737	Transcriptional regulator
HPB53_RS06180	COG1278	Cold shock
HPB53_RS06185	COG0673	inositol 2-dehydrogenase activity
HPB53_RS06190	COG0513	Belongs to the DEAD box helicase family
HPB53_RS06205	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPB53_RS06230	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HPB53_RS06240	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPB53_RS06250	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HPB53_RS06255	COG0562	UDP-galactopyranose mutase
HPB53_RS06260	COG1216	Glycosyl transferase, family 2
HPB53_RS06265	COG0438	transferase activity, transferring glycosyl groups
HPB53_RS06270	COG0438	transferase activity, transferring glycosyl groups
HPB53_RS06290	COG0438	transferase activity, transferring glycosyl groups
HPB53_RS06325	COG1088	dTDP-glucose 4,6-dehydratase activity
HPB53_RS06330	COG0582	viral genome integration into host DNA
HPB53_RS06340	COG0489	protein tyrosine kinase activity
HPB53_RS06345	COG4464	protein tyrosine phosphatase activity
HPB53_RS06360	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HPB53_RS06370	COG1088	dTDP-glucose 4,6-dehydratase activity
HPB53_RS06375	COG1091	dTDP-4-dehydrorhamnose reductase activity
HPB53_RS06395	COG3475	LICD family
HPB53_RS06420	COG1216	Glycosyl transferase, family 2
HPB53_RS06495	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPB53_RS06530	COG2137	regulation of response to DNA damage stimulus
HPB53_RS06535	COG3557	Belongs to the UPF0374 family
HPB53_RS06555	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPB53_RS06565	COG0628	permease
HPB53_RS06570	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HPB53_RS06575	COG2610	gluconate transmembrane transporter activity
HPB53_RS06580	COG1070	Carbohydrate kinase
HPB53_RS06585	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HPB53_RS06590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPB53_RS06595	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HPB53_RS06625	COG4166	transmembrane transport
HPB53_RS06630	COG0601	transmembrane transport
HPB53_RS06635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPB53_RS06640	COG0444	Belongs to the ABC transporter superfamily
HPB53_RS06645	COG4608	Belongs to the ABC transporter superfamily
HPB53_RS06655	COG0582	viral genome integration into host DNA
HPB53_RS06660	COG0542	response to heat
HPB53_RS06680	COG0438	transferase activity, transferring glycosyl groups
HPB53_RS06685	COG0438	transferase activity, transferring glycosyl groups
HPB53_RS06695	COG1686	Belongs to the peptidase S11 family
HPB53_RS06700	COG0436	Aminotransferase
HPB53_RS06705	COG4703	Protein of unknown function (DUF1797)
HPB53_RS06710	COG1368	sulfuric ester hydrolase activity
HPB53_RS06770	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPB53_RS06790	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPB53_RS06800	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HPB53_RS06810	COG2040	homocysteine
HPB53_RS06815	COG0438	transferase activity, transferring glycosyl groups
HPB53_RS06825	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HPB53_RS06830	COG0477	Major facilitator Superfamily
HPB53_RS06845	COG0438	transferase activity, transferring glycosyl groups
HPB53_RS06860	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HPB53_RS06870	COG0495	leucyl-tRNA aminoacylation
HPB53_RS06875	COG2244	polysaccharide biosynthetic process
HPB53_RS06880	COG1187	pseudouridine synthase activity
HPB53_RS06885	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HPB53_RS06890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPB53_RS06900	COG3842	ATPase activity
HPB53_RS06905	COG1175	transmembrane transport
HPB53_RS06910	COG0395	ABC-type sugar transport system, permease component
HPB53_RS06920	COG0584	glycerophosphoryl diester phosphodiesterase
HPB53_RS06925	COG1428	Deoxynucleoside kinase
HPB53_RS06930	COG1970	mechanosensitive ion channel activity
HPB53_RS06935	COG1511	domain protein
HPB53_RS06935	COG1511	domain protein
HPB53_RS06965	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPB53_RS06970	COG0789	Transcriptional regulator
HPB53_RS06980	COG0697	spore germination
HPB53_RS06985	COG0561	phosphatase activity
HPB53_RS07000	COG3279	Response regulator of the LytR AlgR family
HPB53_RS07020	COG1846	Transcriptional regulator
HPB53_RS07035	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPB53_RS07080	COG2176	DNA-directed DNA polymerase activity
HPB53_RS07090	COG1396	sequence-specific DNA binding
HPB53_RS07140	COG0629	single-stranded DNA binding
HPB53_RS07345	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HPB53_RS07345	COG0646	methionine synthase
HPB53_RS07350	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HPB53_RS07360	COG2046	Belongs to the sulfate adenylyltransferase family
HPB53_RS07365	COG0529	Catalyzes the synthesis of activated sulfate
HPB53_RS07370	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HPB53_RS07380	COG0471	metal ion transport
HPB53_RS07380	COG3273	potassium ion transport
HPB53_RS07385	COG0534	Mate efflux family protein
HPB53_RS07405	COG2153	protein acetylation
HPB53_RS07410	COG0018	arginyl-trna synthetase
HPB53_RS07420	COG0577	efflux transmembrane transporter activity
HPB53_RS07420	COG1136	(ABC) transporter
HPB53_RS07435	COG1376	ErfK ybiS ycfS ynhG family protein
HPB53_RS07440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPB53_RS07445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPB53_RS07455	COG0436	Aminotransferase
HPB53_RS07460	COG1438	arginine binding
HPB53_RS07465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPB53_RS07470	COG3679	Belongs to the UPF0342 family
HPB53_RS07475	COG0420	3'-5' exonuclease activity
HPB53_RS07480	COG4717	serine-type aminopeptidase activity
HPB53_RS07485	COG3481	metal-dependent phosphohydrolase, HD sub domain
HPB53_RS07500	COG0583	DNA-binding transcription factor activity
HPB53_RS07510	COG0431	NADPH-dependent FMN reductase
HPB53_RS07510	COG1053	succinate dehydrogenase
HPB53_RS07510	COG3976	FMN-binding domain protein
HPB53_RS07550	COG2217	Heavy metal translocating P-type atpase
HPB53_RS07555	COG0148	phosphopyruvate hydratase activity
HPB53_RS07565	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HPB53_RS07570	COG0463	Glycosyl transferase, family 2
HPB53_RS07590	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPB53_RS07590	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPB53_RS07595	COG0307	riboflavin synthase, alpha
HPB53_RS07600	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPB53_RS07600	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPB53_RS07605	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HPB53_RS07620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPB53_RS07630	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPB53_RS07660	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPB53_RS07670	COG0537	adenosine 5'-monophosphoramidase activity
HPB53_RS07675	COG1131	(ABC) transporter
HPB53_RS07680	COG4473	ABC transporter
HPB53_RS07685	COG0510	thiamine kinase activity
HPB53_RS07690	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HPB53_RS07700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPB53_RS07705	COG1674	ftsk spoiiie
HPB53_RS07710	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPB53_RS07735	COG0719	Fe-S assembly protein
HPB53_RS07740	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPB53_RS07750	COG0719	Fe-S assembly protein
HPB53_RS07755	COG2151	metal-sulfur cluster biosynthetic enzyme
HPB53_RS07770	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPB53_RS07770	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPB53_RS07775	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HPB53_RS07780	COG0237	dephospho-CoA kinase activity
HPB53_RS07785	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HPB53_RS07790	COG3611	Membrane attachment protein
HPB53_RS07795	COG1484	DNA-dependent DNA replication
HPB53_RS07800	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HPB53_RS07805	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HPB53_RS07810	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HPB53_RS07815	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HPB53_RS07825	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPB53_RS07835	COG1733	regulation of RNA biosynthetic process
HPB53_RS07845	COG1215	transferase activity, transferring glycosyl groups
HPB53_RS07860	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HPB53_RS07865	COG1534	Rna-binding protein
HPB53_RS07870	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HPB53_RS07875	COG1713	HD superfamily hydrolase involved in NAD metabolism
HPB53_RS07880	COG0799	negative regulation of ribosome biogenesis
HPB53_RS07885	COG2226	methyltransferase
HPB53_RS07890	COG1323	Belongs to the UPF0348 family
HPB53_RS07900	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HPB53_RS07915	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HPB53_RS07920	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPB53_RS07925	COG0745	RESPONSE REGULATOR receiver
HPB53_RS07930	COG5002	protein histidine kinase activity
HPB53_RS07940	COG0419	ATPase involved in DNA repair
HPB53_RS07955	COG0706	membrane insertase activity
HPB53_RS07960	COG1254	Belongs to the acylphosphatase family
HPB53_RS07965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPB53_RS07975	COG1733	regulation of RNA biosynthetic process
HPB53_RS07980	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HPB53_RS07985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPB53_RS07985	COG0072	phenylalanine-tRNA ligase activity
HPB53_RS07990	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HPB53_RS07995	COG0572	uridine kinase
HPB53_RS08000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPB53_RS08015	COG4841	protein insertion into membrane
HPB53_RS08025	COG0768	penicillin binding
HPB53_RS08030	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HPB53_RS08035	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HPB53_RS08040	COG0705	Rhomboid family
HPB53_RS08040	COG0457	Tetratricopeptide repeat
HPB53_RS08050	COG1940	carbohydrate kinase activity
HPB53_RS08070	COG0584	glycerophosphoryl diester phosphodiesterase
HPB53_RS08075	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HPB53_RS08080	COG0789	Transcriptional regulator
HPB53_RS08130	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HPB53_RS08140	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HPB53_RS08145	COG0006	proline dipeptidase activity
HPB53_RS08150	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPB53_RS08155	COG1302	Protein conserved in bacteria
HPB53_RS08160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPB53_RS08165	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HPB53_RS08170	COG1570	exodeoxyribonuclease VII activity
HPB53_RS08175	COG1722	exodeoxyribonuclease VII activity
HPB53_RS08180	COG0142	geranyltranstransferase activity
HPB53_RS08185	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HPB53_RS08190	COG1438	arginine binding
HPB53_RS08195	COG0497	DNA recombination
HPB53_RS08210	COG1732	Glycine betaine
HPB53_RS08215	COG1174	glycine betaine transport
HPB53_RS08225	COG0194	GDP metabolic process
HPB53_RS08230	COG1758	RNA polymerase activity
HPB53_RS08235	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPB53_RS08240	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPB53_RS08245	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HPB53_RS08250	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPB53_RS08250	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPB53_RS08255	COG0631	protein serine/threonine phosphatase activity
HPB53_RS08260	COG2815	serine threonine protein kinase
HPB53_RS08260	COG0515	serine threonine protein kinase
HPB53_RS08265	COG1162	GTPase activity
HPB53_RS08270	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPB53_RS08275	COG1564	THIamine pyrophosphokinase
HPB53_RS08285	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HPB53_RS08290	COG1302	Protein conserved in bacteria
HPB53_RS08295	COG1461	Dihydroxyacetone kinase
HPB53_RS08300	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPB53_RS08305	COG0416	fatty acid biosynthetic process
HPB53_RS08310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPB53_RS08315	COG0571	ribonuclease III activity
HPB53_RS08320	COG1196	nuclear chromosome segregation
HPB53_RS08325	COG0552	protein localization to endoplasmic reticulum
HPB53_RS08330	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HPB53_RS08335	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPB53_RS08340	COG0228	four-way junction DNA binding
HPB53_RS08345	COG1837	Belongs to the UPF0109 family
HPB53_RS08350	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HPB53_RS08355	COG0336	Belongs to the RNA methyltransferase TrmD family
HPB53_RS08360	COG0335	large ribosomal subunit rRNA binding
HPB53_RS08395	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPB53_RS08395	COG0512	Glutamine amidotransferase of anthranilate synthase
HPB53_RS08400	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPB53_RS08405	COG0134	indole-3-glycerol-phosphate synthase activity
HPB53_RS08410	COG0135	phosphoribosylanthranilate isomerase activity
HPB53_RS08415	COG0133	tryptophan synthase activity
HPB53_RS08420	COG0159	tryptophan synthase activity
HPB53_RS08435	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPB53_RS08445	COG1473	amidohydrolase
HPB53_RS08450	COG1063	alcohol dehydrogenase
HPB53_RS08460	COG0300	oxidoreductase activity
HPB53_RS08470	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPB53_RS08475	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPB53_RS08480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPB53_RS08485	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HPB53_RS08490	COG1028	Short-chain dehydrogenase reductase Sdr
HPB53_RS08495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPB53_RS08510	COG0439	Biotin carboxylase
HPB53_RS08525	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPB53_RS08535	COG1811	Na channel or pump
HPB53_RS08540	COG0583	DNA-binding transcription factor activity
HPB53_RS08545	COG1607	acyl-coa hydrolase
HPB53_RS08550	COG1162	GTPase activity
HPB53_RS08610	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPB53_RS08615	COG3397	chitin binding
HPB53_RS08630	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HPB53_RS08640	COG3152	Membrane
HPB53_RS08645	COG1597	lipid kinase activity
HPB53_RS08655	COG2261	transglycosylase associated protein
HPB53_RS08660	COG3237	CsbD-like
HPB53_RS08675	COG1942	4-Oxalocrotonate Tautomerase
HPB53_RS08710	COG0531	amino acid
HPB53_RS08715	COG0561	phosphatase activity
HPB53_RS08720	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HPB53_RS08720	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPB53_RS08740	COG2017	converts alpha-aldose to the beta-anomer
HPB53_RS08745	COG1304	FMN binding
HPB53_RS08765	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPB53_RS08765	COG1199	ATP-dependent helicase activity
HPB53_RS08780	COG0017	Asparaginyl-tRNA synthetase
HPB53_RS08790	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPB53_RS08795	COG2011	ABC-type metal ion transport system permease component
HPB53_RS08800	COG1464	Belongs to the NlpA lipoprotein family
HPB53_RS08810	COG1177	transmembrane transport
HPB53_RS08830	COG3331	DNA recombination
HPB53_RS08835	COG4474	Belongs to the UPF0398 family
HPB53_RS08840	COG3599	regulation of cell shape
HPB53_RS08850	COG0116	Belongs to the methyltransferase superfamily
HPB53_RS08860	COG0477	Major facilitator Superfamily
HPB53_RS08865	COG1073	alpha beta
HPB53_RS08875	COG1216	Glycosyl transferase, family 2
HPB53_RS08895	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPB53_RS08925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPB53_RS08940	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HPB53_RS08945	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HPB53_RS08950	COG0564	pseudouridine synthase activity
HPB53_RS08955	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HPB53_RS08960	COG0505	Belongs to the CarA family
HPB53_RS08965	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPB53_RS08980	COG5646	InterPro IPR014922
HPB53_RS09015	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HPB53_RS09025	COG1307	EDD domain protein, DegV family
HPB53_RS09080	COG1113	amino acid transport
HPB53_RS09095	COG1620	l-lactate permease
HPB53_RS09105	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HPB53_RS09130	COG1846	Transcriptional regulator
HPB53_RS09135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPB53_RS09170	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPB53_RS09175	COG1227	inorganic diphosphatase activity
HPB53_RS09180	COG0583	DNA-binding transcription factor activity
HPB53_RS09190	COG0187	DNA topoisomerase II activity
HPB53_RS09195	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HPB53_RS09205	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HPB53_RS09210	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HPB53_RS09215	COG4974	Belongs to the 'phage' integrase family
HPB53_RS09220	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HPB53_RS09225	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPB53_RS09230	COG0758	DNA mediated transformation
HPB53_RS09235	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HPB53_RS09240	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HPB53_RS09245	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HPB53_RS09250	COG0583	DNA-binding transcription factor activity
HPB53_RS09270	COG2814	Major facilitator Superfamily
HPB53_RS09275	COG0793	Belongs to the peptidase S41A family
HPB53_RS09275	COG3409	Peptidoglycan-binding domain 1 protein
HPB53_RS09280	COG4479	Belongs to the UPF0346 family
HPB53_RS09285	COG4698	Protein conserved in bacteria
HPB53_RS09290	COG2755	lipolytic protein G-D-S-L family
HPB53_RS09295	COG1307	EDD domain protein, DegV family
HPB53_RS09300	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HPB53_RS09305	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HPB53_RS09310	COG0488	(ABC) transporter
HPB53_RS09320	COG0617	tRNA 3'-terminal CCA addition
HPB53_RS09325	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HPB53_RS09330	COG0561	phosphatase activity
HPB53_RS09335	COG0457	Tetratricopeptide repeat
HPB53_RS09345	COG1160	GTP binding
HPB53_RS09350	COG0539	negative regulation of cytoplasmic translation
HPB53_RS09355	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HPB53_RS09365	COG0514	ATP-dependent DNA helicase (RecQ)
HPB53_RS09375	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HPB53_RS09380	COG1187	pseudouridine synthase activity
HPB53_RS09385	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HPB53_RS09390	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HPB53_RS09400	COG4974	Belongs to the 'phage' integrase family
HPB53_RS09405	COG2996	Protein conserved in bacteria
HPB53_RS09420	COG0205	6-phosphofructokinase activity
HPB53_RS09425	COG0587	DNA-directed DNA polymerase activity
HPB53_RS09440	COG0542	response to heat
HPB53_RS09450	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPB53_RS09455	COG2384	SAM-dependent methyltransferase
HPB53_RS09480	COG0574	Belongs to the PEP-utilizing enzyme family
HPB53_RS09480	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HPB53_RS09490	COG1846	Transcriptional regulator
HPB53_RS09510	COG2217	Heavy metal translocating P-type atpase
HPB53_RS09515	COG0148	phosphopyruvate hydratase activity
HPB53_RS09520	COG0477	Major facilitator Superfamily
HPB53_RS09530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPB53_RS09540	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPB53_RS09545	COG1349	DNA-binding transcription factor activity
HPB53_RS09555	COG1393	Belongs to the ArsC family
HPB53_RS09600	COG0546	phosphoglycolate phosphatase activity
HPB53_RS09630	COG0583	DNA-binding transcription factor activity
HPB53_RS09635	COG0604	alcohol dehydrogenase
HPB53_RS09645	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPB53_RS09650	COG2197	response regulator
HPB53_RS09655	COG4585	Histidine kinase
HPB53_RS09665	COG1131	(ABC) transporter
HPB53_RS09675	COG0519	Catalyzes the synthesis of GMP from XMP
HPB53_RS09705	COG1131	(ABC) transporter
HPB53_RS09725	COG1131	(ABC) transporter
HPB53_RS09730	COG1725	Transcriptional regulator
HPB53_RS09735	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPB53_RS09740	COG0358	DNA primase activity
HPB53_RS09745	COG0751	glycine-tRNA ligase activity
HPB53_RS09750	COG0752	glycyl-tRNA synthetase alpha subunit
HPB53_RS09755	COG1381	Involved in DNA repair and RecF pathway recombination
HPB53_RS09760	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPB53_RS09765	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPB53_RS09770	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HPB53_RS09775	COG1702	phosphate starvation-inducible protein PhoH
HPB53_RS09780	COG1610	YqeY-like protein
HPB53_RS09785	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HPB53_RS09790	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HPB53_RS09800	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HPB53_RS09810	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPB53_RS09820	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HPB53_RS09825	COG0124	histidyl-tRNA synthetase
HPB53_RS09830	COG4991	sh3 domain protein
HPB53_RS09830	COG3103	Sh3 type 3 domain protein
HPB53_RS09830	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPB53_RS09835	COG3001	Fructosamine kinase
HPB53_RS09840	COG0546	phosphoglycolate phosphatase activity
HPB53_RS09845	COG1490	D-aminoacyl-tRNA deacylase activity
HPB53_RS09850	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPB53_RS09860	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPB53_RS09865	COG2264	protein methyltransferase activity
HPB53_RS09870	COG2094	Belongs to the DNA glycosylase MPG family
HPB53_RS09885	COG0481	GTPase activity
HPB53_RS09890	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HPB53_RS09895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPB53_RS09900	COG1696	Membrane protein involved in D-alanine export
HPB53_RS09905	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPB53_RS09915	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPB53_RS09920	COG0484	heat shock protein binding
HPB53_RS09925	COG0443	Heat shock 70 kDa protein
HPB53_RS09930	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPB53_RS09935	COG1420	regulation of RNA biosynthetic process
HPB53_RS09940	COG3527	Alpha-acetolactate decarboxylase
HPB53_RS09945	COG0196	riboflavin kinase activity
HPB53_RS09950	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HPB53_RS09955	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPB53_RS09960	COG0287	Prephenate dehydrogenase
HPB53_RS09965	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HPB53_RS09975	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HPB53_RS09980	COG0738	Major facilitator superfamily
HPB53_RS09985	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HPB53_RS09990	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HPB53_RS10000	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HPB53_RS10005	COG0195	Participates in both transcription termination and antitermination
HPB53_RS10010	COG0779	Required for maturation of 30S ribosomal subunits
HPB53_RS10015	COG2176	DNA-directed DNA polymerase activity
HPB53_RS10020	COG0442	prolyl-tRNA aminoacylation
HPB53_RS10025	COG0750	zinc metalloprotease
HPB53_RS10030	COG4589	Belongs to the CDS family
HPB53_RS10035	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPB53_RS10040	COG0233	cytoplasmic translational termination
HPB53_RS10045	COG0528	UMP kinase activity
HPB53_RS10050	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HPB53_RS10055	COG0052	Belongs to the universal ribosomal protein uS2 family
HPB53_RS10065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPB53_RS10070	COG2827	Endonuclease containing a URI domain
HPB53_RS10075	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HPB53_RS10080	COG0204	Acyl-transferase
HPB53_RS10085	COG3763	UPF0154 protein
HPB53_RS10090	COG4224	UPF0291 protein
HPB53_RS10095	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPB53_RS10110	COG3425	synthase
HPB53_RS10125	COG0463	Glycosyl transferase, family 2
HPB53_RS10195	COG0393	Putative heavy-metal-binding
HPB53_RS10210	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPB53_RS10215	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HPB53_RS10215	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HPB53_RS10220	COG5416	Lipopolysaccharide assembly protein A domain
HPB53_RS10225	COG0300	oxidoreductase activity
HPB53_RS10230	COG1234	tRNA 3'-trailer cleavage
HPB53_RS10240	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HPB53_RS10245	COG1349	DNA-binding transcription factor activity
HPB53_RS10250	COG1105	Belongs to the carbohydrate kinase PfkB family
HPB53_RS10255	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPB53_RS10255	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPB53_RS10255	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPB53_RS10260	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HPB53_RS10285	COG0297	glycogen (starch) synthase activity
HPB53_RS10290	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPB53_RS10295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPB53_RS10305	COG0489	protein tyrosine kinase activity
HPB53_RS10315	COG0322	excinuclease ABC activity
HPB53_RS10320	COG1126	abc transporter atp-binding protein
HPB53_RS10325	COG0765	amino acid transport
HPB53_RS10345	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HPB53_RS10350	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HPB53_RS10355	COG0544	peptidyl-prolyl cis-trans isomerase activity
HPB53_RS10360	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPB53_RS10385	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HPB53_RS10390	COG0268	Binds directly to 16S ribosomal RNA
HPB53_RS10395	COG1466	dna polymerase III delta subunit
HPB53_RS10400	COG2333	competence protein COMEC
HPB53_RS10400	COG0658	competence protein
HPB53_RS10405	COG2131	deaminase
HPB53_RS10410	COG1596	polysaccharide export
HPB53_RS10410	COG1555	photosystem II stabilization
HPB53_RS10415	COG3480	Lon protease (S16) C-terminal proteolytic domain
HPB53_RS10420	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HPB53_RS10425	COG0742	ribosomal rna small subunit methyltransferase
HPB53_RS10430	COG4471	UPF0298 protein
HPB53_RS10435	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HPB53_RS10440	COG0772	Belongs to the SEDS family
HPB53_RS10465	COG1217	gtp-binding protein TYPA
HPB53_RS10470	COG0483	inositol monophosphate 1-phosphatase activity
HPB53_RS10475	COG4476	Belongs to the UPF0223 family
HPB53_RS10480	COG0039	L-malate dehydrogenase activity
HPB53_RS10505	COG0242	peptide deformylase activity
HPB53_RS10515	COG5503	Protein of unknown function (DUF1447)
HPB53_RS10520	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HPB53_RS10525	COG1597	lipid kinase activity
HPB53_RS10540	COG3584	3D domain protein
HPB53_RS10540	COG1388	LysM domain
HPB53_RS10545	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HPB53_RS10550	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HPB53_RS10580	COG0569	domain protein
HPB53_RS10585	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPB53_RS10590	COG0482	sulfurtransferase activity
HPB53_RS10600	COG1104	cysteine desulfurase activity
HPB53_RS10605	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPB53_RS10615	COG0494	nUDIX hydrolase
HPB53_RS10620	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HPB53_RS10625	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HPB53_RS10630	COG3599	regulation of cell shape
HPB53_RS10640	COG0762	integral membrane protein
HPB53_RS10645	COG1799	cell septum assembly
HPB53_RS10660	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HPB53_RS10665	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPB53_RS10670	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HPB53_RS10675	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPB53_RS10680	COG0768	penicillin binding
HPB53_RS10690	COG0275	rRNA processing
HPB53_RS10695	COG2001	Belongs to the MraZ family
HPB53_RS10715	COG1674	ftsk spoiiie
HPB53_RS10720	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HPB53_RS10730	COG1114	Component of the transport system for branched-chain amino acids
HPB53_RS10745	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HPB53_RS10750	COG0628	permease
HPB53_RS10760	COG2706	6-phosphogluconolactonase activity
HPB53_RS10765	COG3142	Participates in the control of copper homeostasis
HPB53_RS10770	COG0564	pseudouridine synthase activity
HPB53_RS10775	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HPB53_RS10780	COG2357	RelA SpoT domain protein
HPB53_RS10790	COG1164	Oligoendopeptidase f
HPB53_RS10800	COG4862	establishment of competence for transformation
HPB53_RS10805	COG1393	Belongs to the ArsC family
HPB53_RS10810	COG1234	tRNA 3'-trailer cleavage
HPB53_RS10940	COG1098	S1 RNA binding domain
HPB53_RS10950	COG0586	Pfam SNARE associated Golgi protein
HPB53_RS10960	COG0647	UMP catabolic process
HPB53_RS10965	COG4470	Protein conserved in bacteria
HPB53_RS10970	COG0737	Belongs to the 5'-nucleotidase family
HPB53_RS10980	COG1113	amino acid transport
HPB53_RS10985	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPB53_RS10990	COG0827	DNA restriction-modification system
HPB53_RS11020	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPB53_RS11030	COG0217	transcriptional regulatory protein
HPB53_RS11045	COG1609	Transcriptional regulator
HPB53_RS11050	COG0006	proline dipeptidase activity
HPB53_RS11055	COG0789	Transcriptional regulator
HPB53_RS11070	COG0668	transmembrane transport
HPB53_RS11075	COG1473	amidohydrolase
HPB53_RS11080	COG2171	N-acyltransferase activity
HPB53_RS11085	COG0517	IMP dehydrogenase activity
HPB53_RS11095	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HPB53_RS11100	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HPB53_RS11105	COG1719	4-vinyl reductase, 4VR
HPB53_RS11110	COG3118	belongs to the thioredoxin family
HPB53_RS11115	COG1193	negative regulation of DNA recombination
HPB53_RS11125	COG3906	Belongs to the UPF0473 family
HPB53_RS11130	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HPB53_RS11135	COG4472	Bacterial protein of unknown function (DUF965)
HPB53_RS11140	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPB53_RS11145	COG0513	Belongs to the DEAD box helicase family
HPB53_RS11150	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HPB53_RS11155	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HPB53_RS11160	COG1862	Preprotein translocase
HPB53_RS11165	COG0343	queuine tRNA-ribosyltransferase activity
HPB53_RS11170	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HPB53_RS11175	COG2255	four-way junction helicase activity
HPB53_RS11180	COG0632	four-way junction helicase activity
HPB53_RS11200	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HPB53_RS11205	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HPB53_RS11210	COG1692	metallophosphoesterase
HPB53_RS11215	COG1418	mRNA catabolic process
HPB53_RS11220	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HPB53_RS11225	COG1058	Belongs to the CinA family
HPB53_RS11225	COG1546	Belongs to the CinA family
HPB53_RS11230	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPB53_RS11235	COG1426	Protein conserved in bacteria
HPB53_RS11240	COG0612	Peptidase, M16
HPB53_RS11245	COG0612	Peptidase, M16
HPB53_RS11250	COG0527	aspartate kinase activity
HPB53_RS11255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPB53_RS11260	COG1126	abc transporter atp-binding protein
HPB53_RS11265	COG0765	amino acid transport
HPB53_RS11270	COG2894	cell division
HPB53_RS11275	COG0850	regulation of cytokinetic process
HPB53_RS11285	COG1792	Involved in formation and maintenance of cell shape
HPB53_RS11290	COG1077	Cell shape determining protein MreB Mrl
HPB53_RS11295	COG2003	Belongs to the UPF0758 family
HPB53_RS11300	COG0285	dihydrofolate synthase activity
HPB53_RS11305	COG0525	valine-tRNA ligase activity
HPB53_RS11315	COG1181	Belongs to the D-alanine--D-alanine ligase family
HPB53_RS11315	COG2918	glutathione biosynthetic process
HPB53_RS11320	COG0301	tRNA thio-modification
HPB53_RS11325	COG1104	cysteine desulfurase activity
HPB53_RS11330	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HPB53_RS11335	COG1956	GAF domain-containing protein
HPB53_RS11340	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HPB53_RS11345	COG4493	Belongs to the UPF0637 family
HPB53_RS11360	COG0640	Transcriptional regulator
HPB53_RS11365	COG0366	Alpha amylase catalytic
HPB53_RS11375	COG3716	PTS system mannose fructose sorbose family IID component
HPB53_RS11380	COG3715	PTS system
HPB53_RS11385	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPB53_RS11390	COG1609	Transcriptional regulator
HPB53_RS11395	COG0189	ligase activity
HPB53_RS11395	COG2918	glutathione biosynthetic process
HPB53_RS11400	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPB53_RS11415	COG0589	response to stress
HPB53_RS11435	COG1181	Belongs to the D-alanine--D-alanine ligase family
HPB53_RS11455	COG1464	Belongs to the NlpA lipoprotein family
HPB53_RS11460	COG2011	ABC-type metal ion transport system permease component
HPB53_RS11465	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPB53_RS11470	COG0509	glycine decarboxylation via glycine cleavage system
HPB53_RS11475	COG0772	Belongs to the SEDS family
HPB53_RS11485	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HPB53_RS11490	COG1077	Cell shape determining protein MreB Mrl
HPB53_RS11500	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HPB53_RS11505	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HPB53_RS11510	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HPB53_RS11515	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HPB53_RS11520	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HPB53_RS11525	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HPB53_RS11530	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HPB53_RS11535	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HPB53_RS11540	COG0356	it plays a direct role in the translocation of protons across the membrane
HPB53_RS11545	COG2233	PERMEase
HPB53_RS11555	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HPB53_RS11560	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPB53_RS11565	COG0009	L-threonylcarbamoyladenylate synthase
HPB53_RS11570	COG2890	protein-(glutamine-N5) methyltransferase activity
HPB53_RS11575	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HPB53_RS11580	COG1435	thymidine kinase activity
HPB53_RS11585	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPB53_RS11590	COG3442	glutamine amidotransferase
HPB53_RS11595	COG1482	cell wall glycoprotein biosynthetic process
HPB53_RS11600	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPB53_RS11610	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPB53_RS11625	COG1132	(ABC) transporter
HPB53_RS11640	COG0726	polysaccharide deacetylase
HPB53_RS11680	COG4695	Portal protein
HPB53_RS11745	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HPB53_RS11770	COG4932	domain protein
HPB53_RS11770	COG4886	Leucine-rich repeat (LRR) protein
HPB53_RS11785	COG1132	(ABC) transporter
HPB53_RS11795	COG1136	(ABC) transporter
HPB53_RS11795	COG0577	efflux transmembrane transporter activity
HPB53_RS11805	COG0166	Belongs to the GPI family
HPB53_RS11810	COG4975	Glucose uptake
HPB53_RS11815	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPB53_RS11820	COG3850	Histidine kinase
HPB53_RS11820	COG5002	protein histidine kinase activity
HPB53_RS11825	COG0745	RESPONSE REGULATOR receiver
HPB53_RS11830	COG2848	UPF0210 protein
HPB53_RS11835	COG3830	Belongs to the UPF0237 family
HPB53_RS11860	COG0477	Major facilitator Superfamily
HPB53_RS11880	COG0791	NLP P60 protein
HPB53_RS11885	COG1522	sequence-specific DNA binding
HPB53_RS11905	COG0488	(ABC) transporter
HPB53_RS11925	COG2190	(PTS) system
HPB53_RS11925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPB53_RS11925	COG1263	PTS System
HPB53_RS11930	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPB53_RS11935	COG1307	EDD domain protein, DegV family
HPB53_RS11945	COG2873	o-acetylhomoserine
HPB53_RS11950	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HPB53_RS11960	COG4120	Belongs to the binding-protein-dependent transport system permease family
HPB53_RS11970	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPB53_RS11975	COG2084	Dehydrogenase
HPB53_RS11980	COG0861	Integral membrane protein TerC family
HPB53_RS11985	COG0110	maltose O-acetyltransferase activity
HPB53_RS11990	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPB53_RS11995	COG0140	phosphoribosyl-ATP diphosphatase activity
HPB53_RS12000	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HPB53_RS12005	COG0107	imidazoleglycerol-phosphate synthase activity
HPB53_RS12010	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPB53_RS12015	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HPB53_RS12020	COG0131	Imidazoleglycerol-phosphate dehydratase
HPB53_RS12025	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HPB53_RS12030	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HPB53_RS12035	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HPB53_RS12040	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HPB53_RS12060	COG0789	Transcriptional regulator
HPB53_RS12065	COG0300	oxidoreductase activity
HPB53_RS12075	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPB53_RS12090	COG3548	integral membrane protein
HPB53_RS12110	COG1368	sulfuric ester hydrolase activity
HPB53_RS12115	COG0584	glycerophosphoryl diester phosphodiesterase
HPB53_RS12120	COG0492	ferredoxin-NADP+ reductase activity
HPB53_RS12130	COG4932	domain protein
HPB53_RS12135	COG2326	polyphosphate kinase activity
HPB53_RS12140	COG0778	Nitroreductase
HPB53_RS12150	COG0328	RNA-DNA hybrid ribonuclease activity
HPB53_RS12160	COG1609	Transcriptional regulator
HPB53_RS12170	COG0673	inositol 2-dehydrogenase activity
HPB53_RS12175	COG0673	inositol 2-dehydrogenase activity
HPB53_RS12180	COG0025	NhaP-type Na H and K H
HPB53_RS12185	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HPB53_RS12190	COG1335	isochorismatase
HPB53_RS12200	COG1131	(ABC) transporter
HPB53_RS12205	COG1725	Transcriptional regulator
HPB53_RS12245	COG0028	Belongs to the TPP enzyme family
HPB53_RS12255	COG1073	alpha beta
HPB53_RS12260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPB53_RS12265	COG0626	cystathionine gamma-synthase activity
HPB53_RS12295	COG0095	Lipoate-protein ligase
HPB53_RS12300	COG1705	Flagellar rod assembly protein muramidase FlgJ
HPB53_RS12310	COG3716	PTS system mannose fructose sorbose family IID component
HPB53_RS12315	COG3715	PTS system
HPB53_RS12320	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPB53_RS12325	COG2188	Transcriptional regulator
HPB53_RS12330	COG0589	response to stress
HPB53_RS12335	COG0564	pseudouridine synthase activity
HPB53_RS12360	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HPB53_RS12370	COG2188	Transcriptional regulator
HPB53_RS12375	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPB53_RS12385	COG1418	mRNA catabolic process
HPB53_RS12415	COG1253	flavin adenine dinucleotide binding
HPB53_RS12420	COG1780	Probably involved in ribonucleotide reductase function
HPB53_RS12425	COG0025	NhaP-type Na H and K H
HPB53_RS12430	COG2814	Major facilitator Superfamily
HPB53_RS12435	COG0789	Transcriptional regulator
HPB53_RS12440	COG0604	alcohol dehydrogenase
HPB53_RS12450	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPB53_RS12455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPB53_RS12460	COG0436	Aminotransferase
HPB53_RS12475	COG0583	DNA-binding transcription factor activity
HPB53_RS12480	COG0702	epimerase
HPB53_RS12490	COG1074	ATP-dependent DNA helicase activity
HPB53_RS12495	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HPB53_RS12505	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPB53_RS12510	COG0284	orotidine-5'-phosphate decarboxylase activity
HPB53_RS12515	COG0167	dihydroorotate dehydrogenase activity
HPB53_RS12520	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPB53_RS12525	COG0505	Belongs to the CarA family
HPB53_RS12530	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HPB53_RS12535	COG0540	Belongs to the ATCase OTCase family
HPB53_RS12540	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HPB53_RS12545	COG2508	Transcriptional regulator
HPB53_RS12550	COG2233	PERMEase
HPB53_RS12555	COG2252	PERMEase
HPB53_RS12575	COG1215	transferase activity, transferring glycosyl groups
HPB53_RS12585	COG0151	Belongs to the GarS family
HPB53_RS12590	COG0138	bifunctional purine biosynthesis protein purh
HPB53_RS12595	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HPB53_RS12600	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HPB53_RS12610	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPB53_RS12615	COG0047	phosphoribosylformylglycinamidine synthase activity
HPB53_RS12620	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPB53_RS12625	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HPB53_RS12630	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HPB53_RS12640	COG1053	succinate dehydrogenase
HPB53_RS12640	COG3976	FMN-binding domain protein
HPB53_RS12640	COG0431	NADPH-dependent FMN reductase
HPB53_RS12645	COG0431	NADPH-dependent FMN reductase
HPB53_RS12645	COG1053	succinate dehydrogenase
HPB53_RS12645	COG3976	FMN-binding domain protein
HPB53_RS12650	COG0095	Lipoate-protein ligase
HPB53_RS12655	COG2365	Tyrosine phosphatase family
HPB53_RS12675	COG1136	(ABC) transporter
HPB53_RS12690	COG1725	Transcriptional regulator
HPB53_RS12695	COG1131	(ABC) transporter
HPB53_RS12705	COG0589	response to stress
HPB53_RS12715	COG2246	polysaccharide biosynthetic process
HPB53_RS12730	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HPB53_RS12750	COG0366	Alpha amylase catalytic
HPB53_RS12760	COG0561	phosphatase activity
HPB53_RS12770	COG0110	maltose O-acetyltransferase activity
HPB53_RS12775	COG0494	nUDIX hydrolase
HPB53_RS12805	COG1827	regulation of RNA biosynthetic process
HPB53_RS12810	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HPB53_RS12815	COG1309	transcriptional regulator
HPB53_RS12825	COG1131	(ABC) transporter
HPB53_RS12830	COG3048	D-serine ammonia-lyase activity
HPB53_RS12835	COG2723	6-phospho-beta-galactosidase activity
HPB53_RS12840	COG2723	6-phospho-beta-galactosidase activity
HPB53_RS12845	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPB53_RS12850	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPB53_RS12855	COG2188	Transcriptional regulator
HPB53_RS12860	COG1215	transferase activity, transferring glycosyl groups
HPB53_RS12875	COG0561	phosphatase activity
HPB53_RS12880	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPB53_RS12905	COG0716	FMN binding
HPB53_RS12925	COG0710	3-dehydroquinate dehydratase activity
HPB53_RS12930	COG0531	amino acid
HPB53_RS12965	COG4720	Psort location CytoplasmicMembrane, score
HPB53_RS12970	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPB53_RS12985	COG4990	cell redox homeostasis
HPB53_RS13000	COG1811	Na channel or pump
HPB53_RS13005	COG0789	Transcriptional regulator
HPB53_RS13005	COG4978	Transcriptional regulator
HPB53_RS13020	COG0577	efflux transmembrane transporter activity
HPB53_RS13025	COG1136	(ABC) transporter
HPB53_RS13065	COG2814	Major facilitator Superfamily
HPB53_RS13075	COG2814	Major facilitator Superfamily
HPB53_RS13085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPB53_RS13090	COG2855	membrane
HPB53_RS13095	COG0583	DNA-binding transcription factor activity
HPB53_RS13105	COG0438	transferase activity, transferring glycosyl groups
HPB53_RS13120	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPB53_RS13125	COG4152	abc transporter atp-binding protein
HPB53_RS13135	COG4221	oxidoreductase activity
HPB53_RS13150	COG0789	Transcriptional regulator
HPB53_RS13170	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPB53_RS13190	COG0456	acetyltransferase
HPB53_RS13215	COG0583	DNA-binding transcription factor activity
HPB53_RS13225	COG1063	alcohol dehydrogenase
HPB53_RS13230	COG1028	Short-chain dehydrogenase reductase Sdr
HPB53_RS13255	COG4975	Glucose uptake
HPB53_RS13265	COG0656	L-ascorbic acid biosynthetic process
HPB53_RS13270	COG0583	DNA-binding transcription factor activity
HPB53_RS13290	COG4221	oxidoreductase activity
HPB53_RS13295	COG0656	L-ascorbic acid biosynthetic process
HPB53_RS13320	COG1396	sequence-specific DNA binding
HPB53_RS13330	COG0589	response to stress
HPB53_RS13335	COG0110	maltose O-acetyltransferase activity
HPB53_RS13340	COG1011	Hydrolase
HPB53_RS13355	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HPB53_RS13365	COG0667	Aldo Keto reductase
HPB53_RS13370	COG1132	(ABC) transporter
HPB53_RS13375	COG1132	(ABC) transporter
HPB53_RS13380	COG2814	Major facilitator Superfamily
HPB53_RS13390	COG1511	domain protein
HPB53_RS13390	COG1511	domain protein
HPB53_RS13400	COG0640	Transcriptional regulator
HPB53_RS13430	COG0488	(ABC) transporter
HPB53_RS13435	COG0561	phosphatase activity
HPB53_RS13445	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPB53_RS13460	COG2270	Major facilitator Superfamily
HPB53_RS13500	COG2200	EAL domain
HPB53_RS13510	COG1328	CTP reductase activity
HPB53_RS13520	COG0242	peptide deformylase activity
HPB53_RS13530	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPB53_RS13545	COG0583	DNA-binding transcription factor activity
HPB53_RS13555	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HPB53_RS13600	COG0697	spore germination
HPB53_RS13630	COG1132	(ABC) transporter
HPB53_RS13640	COG0778	Nitroreductase
HPB53_RS13645	COG1263	PTS System
HPB53_RS13645	COG2190	(PTS) system
HPB53_RS13645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPB53_RS13650	COG1116	anion transmembrane transporter activity
HPB53_RS13655	COG4120	Belongs to the binding-protein-dependent transport system permease family
HPB53_RS13690	COG0410	ABC transporter
HPB53_RS13705	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPB53_RS13720	COG5549	protein import
HPB53_RS13720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPB53_RS13725	COG2246	polysaccharide biosynthetic process
HPB53_RS13735	COG1914	H( )-stimulated, divalent metal cation uptake system
HPB53_RS13755	COG0640	Transcriptional regulator
HPB53_RS13765	COG0577	efflux transmembrane transporter activity
HPB53_RS13765	COG1136	(ABC) transporter
HPB53_RS13800	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPB53_RS13805	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPB53_RS13810	COG2723	6-phospho-beta-galactosidase activity
HPB53_RS13820	COG0789	Transcriptional regulator
HPB53_RS13825	COG0741	lytic transglycosylase activity
HPB53_RS13830	COG0741	lytic transglycosylase activity
HPB53_RS13845	COG0803	Belongs to the bacterial solute-binding protein 9 family
HPB53_RS13870	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HPB53_RS13885	COG4221	oxidoreductase activity
HPB53_RS13915	COG1028	Short-chain dehydrogenase reductase Sdr
HPB53_RS13930	COG1132	(ABC) transporter
HPB53_RS13935	COG1132	(ABC) transporter
HPB53_RS13945	COG1473	amidohydrolase
HPB53_RS13950	COG1028	Short-chain dehydrogenase reductase Sdr
HPB53_RS13970	COG0531	amino acid
HPB53_RS13990	COG2217	Heavy metal translocating P-type atpase
HPB53_RS14045	COG1063	alcohol dehydrogenase
HPB53_RS14085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPB53_RS14090	COG1733	regulation of RNA biosynthetic process
HPB53_RS14095	COG2814	Major facilitator Superfamily
HPB53_RS14105	COG0367	asparagine synthase
HPB53_RS14110	COG3279	Response regulator of the LytR AlgR family
HPB53_RS14120	COG1309	transcriptional regulator
HPB53_RS14130	COG1012	belongs to the aldehyde dehydrogenase family
HPB53_RS14145	COG1733	regulation of RNA biosynthetic process
HPB53_RS14150	COG0300	oxidoreductase activity
HPB53_RS14170	COG0667	Aldo Keto reductase
HPB53_RS14175	COG0477	Major facilitator Superfamily
HPB53_RS14185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPB53_RS14190	COG1120	ATPase activity
HPB53_RS14195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPB53_RS14200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPB53_RS14205	COG1309	transcriptional regulator
HPB53_RS14215	COG4221	oxidoreductase activity
HPB53_RS14220	COG0110	maltose O-acetyltransferase activity
HPB53_RS14225	COG1028	Short-chain dehydrogenase reductase Sdr
HPB53_RS14260	COG0481	GTPase activity
HPB53_RS14270	COG2816	NAD+ diphosphatase activity
HPB53_RS14280	COG1053	succinate dehydrogenase
HPB53_RS14280	COG3976	FMN-binding domain protein
HPB53_RS14280	COG0431	NADPH-dependent FMN reductase
HPB53_RS14290	COG0783	Belongs to the Dps family
HPB53_RS14310	COG2723	6-phospho-beta-galactosidase activity
HPB53_RS14315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPB53_RS14315	COG2190	(PTS) system
HPB53_RS14315	COG1263	PTS System
HPB53_RS14340	COG3711	transcriptional antiterminator
HPB53_RS14355	COG0693	protein deglycase activity
HPB53_RS14370	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HPB53_RS14390	COG1376	ErfK ybiS ycfS ynhG family protein
HPB53_RS14395	COG0656	L-ascorbic acid biosynthetic process
HPB53_RS14410	COG0477	Major facilitator Superfamily
HPB53_RS14440	COG0588	phosphoglycerate mutase activity
HPB53_RS14445	COG0628	permease
HPB53_RS14450	COG1846	Transcriptional regulator
HPB53_RS14450	COG1940	carbohydrate kinase activity
HPB53_RS14460	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPB53_RS14470	COG2815	serine threonine protein kinase
HPB53_RS14470	COG0515	serine threonine protein kinase
HPB53_RS14505	COG1247	-acetyltransferase
HPB53_RS14510	COG1686	Belongs to the peptidase S11 family
HPB53_RS14530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPB53_RS14535	COG0517	IMP dehydrogenase activity
HPB53_RS14535	COG0516	GMP reductase activity
HPB53_RS14545	COG0012	GTP binding
HPB53_RS14550	COG4481	Protein conserved in bacteria
HPB53_RS14555	COG1475	DNA binding
HPB53_RS14560	COG1192	Involved in chromosome partitioning
HPB53_RS14570	COG0357	Ribosomal RNA small subunit methyltransferase G
HPB53_RS14575	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPB53_RS14590	COG0583	DNA-binding transcription factor activity
HPB53_RS14595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPB53_RS14600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPB53_RS14605	COG0765	amino acid transport
HPB53_RS14610	COG1126	abc transporter atp-binding protein
HPB53_RS14615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPB53_RS14640	COG2190	(PTS) system
HPB53_RS14640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPB53_RS14640	COG1263	PTS System
HPB53_RS14645	COG0366	Alpha amylase catalytic
HPB53_RS14650	COG1609	Transcriptional regulator
HPB53_RS14660	COG0390	transport system, permease component
HPB53_RS14665	COG4619	ABC transporter
HPB53_RS14670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPB53_RS14685	COG0561	phosphatase activity
HPB53_RS14695	COG0383	alpha-mannosidase activity
HPB53_RS14700	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPB53_RS14700	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPB53_RS14700	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPB53_RS14705	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPB53_RS14710	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPB53_RS14710	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPB53_RS14710	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPB53_RS14715	COG3711	transcriptional antiterminator
HPB53_RS14715	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPB53_RS14730	COG2190	(PTS) system
HPB53_RS14730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPB53_RS14730	COG1263	PTS System
HPB53_RS14760	COG0735	belongs to the Fur family
HPB53_RS14785	COG1380	Effector of murein hydrolase LrgA
HPB53_RS14795	COG1307	EDD domain protein, DegV family
HPB53_RS14805	COG2738	Putative neutral zinc metallopeptidase
HPB53_RS14810	COG1233	COG1233 Phytoene dehydrogenase and related
HPB53_RS14815	COG1562	ergosterol biosynthetic process
HPB53_RS14825	COG1929	Belongs to the glycerate kinase type-1 family
HPB53_RS14840	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPB53_RS14845	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPB53_RS14850	COG0516	GMP reductase activity
HPB53_RS14855	COG2365	Tyrosine phosphatase family
HPB53_RS14860	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPB53_RS14885	COG0531	amino acid
HPB53_RS14890	COG3158	transport of potassium into the cell
HPB53_RS14895	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPB53_RS14900	COG0628	permease
HPB53_RS14905	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HPB53_RS14920	COG1272	protein, Hemolysin III
HPB53_RS14925	COG0640	Transcriptional regulator
HPB53_RS14935	COG3620	sequence-specific DNA binding
HPB53_RS14960	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HPB53_RS14970	COG0302	gtp cyclohydrolase
HPB53_RS14975	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPB53_RS14990	COG0803	Belongs to the bacterial solute-binding protein 9 family
HPB53_RS14995	COG2814	Major facilitator Superfamily
HPB53_RS15015	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPB53_RS15020	COG1882	Formate acetyltransferase
HPB53_RS15025	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPB53_RS15035	COG2151	metal-sulfur cluster biosynthetic enzyme
HPB53_RS15040	COG4989	oxidoreductase activity
HPB53_RS15070	COG2217	Heavy metal translocating P-type atpase
HPB53_RS15080	COG2315	Protein conserved in bacteria
HPB53_RS15090	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HPB53_RS15095	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HPB53_RS15220	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPB53_RS15220	COG0551	DNA topoisomerase type I activity
HPB53_RS15235	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPB53_RS15250	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HPB53_RS15285	COG0477	Major facilitator Superfamily
HPB53_RS15310	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPB53_RS15320	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HPB53_RS15325	COG1984	allophanate hydrolase subunit 2
HPB53_RS15330	COG0511	ligase activity, forming carbon-carbon bonds
HPB53_RS15335	COG0439	Biotin carboxylase
HPB53_RS15340	COG4336	lyase activity
HPB53_RS15345	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HPB53_RS15350	COG1914	H( )-stimulated, divalent metal cation uptake system
HPB53_RS15370	COG2814	Major facilitator Superfamily
HPB53_RS15375	COG5039	Polysaccharide pyruvyl transferase
HPB53_RS15380	COG2814	Major facilitator Superfamily
HPB53_RS15385	COG2261	transglycosylase associated protein
HPB53_RS15410	COG1192	Involved in chromosome partitioning
HPB53_RS15415	COG3842	ATPase activity
HPB53_RS15420	COG1653	transport
HPB53_RS15440	COG2801	Transposase and inactivated derivatives
HPB53_RS15470	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPB53_RS15560	COG0191	fructose-bisphosphate aldolase activity
HPB53_RS15565	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPB53_RS15565	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPB53_RS15565	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPB53_RS15580	COG3620	sequence-specific DNA binding
HPB53_RS15610	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HPB53_RS15615	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HPB53_RS15620	COG2205	protein histidine kinase activity
HPB53_RS15625	COG0745	RESPONSE REGULATOR receiver
HPB53_RS15630	COG3158	transport of potassium into the cell
HPB53_RS15635	COG1846	Transcriptional regulator
HPB53_RS15640	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HPB53_RS15645	COG2814	Major facilitator Superfamily
HPB53_RS15670	COG4716	Myosin-crossreactive antigen
HPB53_RS15680	COG4876	unkown
HPB53_RS15695	COG1376	ErfK ybiS ycfS ynhG family protein
HPB53_RS15760	COG1705	Flagellar rod assembly protein muramidase FlgJ
HPB53_RS15815	COG1192	Involved in chromosome partitioning