locus-tag	class	description
D0Y51_RS00005	COG4608	Belongs to the ABC transporter superfamily
D0Y51_RS00015	COG0582	viral genome integration into host DNA
D0Y51_RS00020	COG0542	response to heat
D0Y51_RS00040	COG0438	transferase activity, transferring glycosyl groups
D0Y51_RS00045	COG0438	transferase activity, transferring glycosyl groups
D0Y51_RS00055	COG1686	Belongs to the peptidase S11 family
D0Y51_RS00060	COG0436	Aminotransferase
D0Y51_RS00065	COG4703	Protein of unknown function (DUF1797)
D0Y51_RS00070	COG1368	sulfuric ester hydrolase activity
D0Y51_RS00160	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D0Y51_RS00180	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D0Y51_RS00195	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D0Y51_RS00200	COG0833	amino acid
D0Y51_RS00205	COG2040	homocysteine
D0Y51_RS00210	COG0438	transferase activity, transferring glycosyl groups
D0Y51_RS00220	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D0Y51_RS00225	COG0477	Major facilitator Superfamily
D0Y51_RS00240	COG0438	transferase activity, transferring glycosyl groups
D0Y51_RS00255	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
D0Y51_RS00265	COG0495	leucyl-tRNA aminoacylation
D0Y51_RS00270	COG2244	polysaccharide biosynthetic process
D0Y51_RS00275	COG1187	pseudouridine synthase activity
D0Y51_RS00280	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D0Y51_RS00285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D0Y51_RS00295	COG3842	ATPase activity
D0Y51_RS00300	COG1175	transmembrane transport
D0Y51_RS00305	COG0395	ABC-type sugar transport system, permease component
D0Y51_RS00315	COG0584	glycerophosphoryl diester phosphodiesterase
D0Y51_RS00320	COG1428	Deoxynucleoside kinase
D0Y51_RS00325	COG1970	mechanosensitive ion channel activity
D0Y51_RS00330	COG1511	domain protein
D0Y51_RS00330	COG1511	domain protein
D0Y51_RS00360	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D0Y51_RS00365	COG0789	Transcriptional regulator
D0Y51_RS00375	COG0697	spore germination
D0Y51_RS00380	COG0561	phosphatase activity
D0Y51_RS00400	COG3279	Response regulator of the LytR AlgR family
D0Y51_RS00420	COG1846	Transcriptional regulator
D0Y51_RS00435	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D0Y51_RS00475	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D0Y51_RS00475	COG0646	methionine synthase
D0Y51_RS00480	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D0Y51_RS00490	COG2046	Belongs to the sulfate adenylyltransferase family
D0Y51_RS00495	COG0529	Catalyzes the synthesis of activated sulfate
D0Y51_RS00500	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D0Y51_RS00510	COG3273	potassium ion transport
D0Y51_RS00510	COG0471	metal ion transport
D0Y51_RS00515	COG0534	Mate efflux family protein
D0Y51_RS00535	COG2153	protein acetylation
D0Y51_RS00540	COG0018	arginyl-trna synthetase
D0Y51_RS00550	COG1136	(ABC) transporter
D0Y51_RS00550	COG0577	efflux transmembrane transporter activity
D0Y51_RS00570	COG1447	Phosphotransferase system cellobiose-specific component IIA
D0Y51_RS00575	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0Y51_RS00580	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0Y51_RS00585	COG2723	6-phospho-beta-galactosidase activity
D0Y51_RS00595	COG1376	ErfK ybiS ycfS ynhG family protein
D0Y51_RS00600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D0Y51_RS00605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0Y51_RS00615	COG0436	Aminotransferase
D0Y51_RS00620	COG1438	arginine binding
D0Y51_RS00630	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D0Y51_RS00635	COG3679	Belongs to the UPF0342 family
D0Y51_RS00640	COG0420	3'-5' exonuclease activity
D0Y51_RS00645	COG4717	serine-type aminopeptidase activity
D0Y51_RS00650	COG3481	metal-dependent phosphohydrolase, HD sub domain
D0Y51_RS00665	COG0583	DNA-binding transcription factor activity
D0Y51_RS00675	COG3976	FMN-binding domain protein
D0Y51_RS00675	COG1053	succinate dehydrogenase
D0Y51_RS00675	COG0431	NADPH-dependent FMN reductase
D0Y51_RS00725	COG2217	Heavy metal translocating P-type atpase
D0Y51_RS00730	COG0148	phosphopyruvate hydratase activity
D0Y51_RS00740	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D0Y51_RS00750	COG0463	Glycosyl transferase, family 2
D0Y51_RS00770	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D0Y51_RS00770	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D0Y51_RS00775	COG0307	riboflavin synthase, alpha
D0Y51_RS00780	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D0Y51_RS00780	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D0Y51_RS00785	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D0Y51_RS00800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D0Y51_RS00810	COG0446	pyridine nucleotide-disulphide oxidoreductase
D0Y51_RS00840	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D0Y51_RS00850	COG0537	adenosine 5'-monophosphoramidase activity
D0Y51_RS00855	COG1131	(ABC) transporter
D0Y51_RS00860	COG4473	ABC transporter
D0Y51_RS00865	COG0510	thiamine kinase activity
D0Y51_RS00870	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D0Y51_RS00880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D0Y51_RS00885	COG1674	ftsk spoiiie
D0Y51_RS00890	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D0Y51_RS00915	COG0719	Fe-S assembly protein
D0Y51_RS00920	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D0Y51_RS00930	COG0719	Fe-S assembly protein
D0Y51_RS00935	COG2151	metal-sulfur cluster biosynthetic enzyme
D0Y51_RS00950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D0Y51_RS00950	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D0Y51_RS00955	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D0Y51_RS00960	COG0237	dephospho-CoA kinase activity
D0Y51_RS00965	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D0Y51_RS00970	COG3611	Membrane attachment protein
D0Y51_RS00975	COG1484	DNA-dependent DNA replication
D0Y51_RS00980	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D0Y51_RS00985	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D0Y51_RS00990	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D0Y51_RS00995	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D0Y51_RS01005	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D0Y51_RS01010	COG0604	alcohol dehydrogenase
D0Y51_RS01015	COG1733	regulation of RNA biosynthetic process
D0Y51_RS01025	COG1215	transferase activity, transferring glycosyl groups
D0Y51_RS01040	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D0Y51_RS01045	COG1534	Rna-binding protein
D0Y51_RS01050	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D0Y51_RS01055	COG1713	HD superfamily hydrolase involved in NAD metabolism
D0Y51_RS01060	COG0799	negative regulation of ribosome biogenesis
D0Y51_RS01065	COG2226	methyltransferase
D0Y51_RS01070	COG1323	Belongs to the UPF0348 family
D0Y51_RS01080	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D0Y51_RS01095	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D0Y51_RS01100	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D0Y51_RS01105	COG0745	RESPONSE REGULATOR receiver
D0Y51_RS01110	COG5002	protein histidine kinase activity
D0Y51_RS01120	COG0419	ATPase involved in DNA repair
D0Y51_RS01135	COG0706	membrane insertase activity
D0Y51_RS01140	COG1254	Belongs to the acylphosphatase family
D0Y51_RS01145	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D0Y51_RS01155	COG1733	regulation of RNA biosynthetic process
D0Y51_RS01160	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D0Y51_RS01165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D0Y51_RS01165	COG0072	phenylalanine-tRNA ligase activity
D0Y51_RS01170	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D0Y51_RS01175	COG0572	uridine kinase
D0Y51_RS01180	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D0Y51_RS01200	COG4841	protein insertion into membrane
D0Y51_RS01210	COG0768	penicillin binding
D0Y51_RS01215	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D0Y51_RS01220	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D0Y51_RS01225	COG0457	Tetratricopeptide repeat
D0Y51_RS01225	COG0705	Rhomboid family
D0Y51_RS01235	COG1940	carbohydrate kinase activity
D0Y51_RS01255	COG0584	glycerophosphoryl diester phosphodiesterase
D0Y51_RS01260	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D0Y51_RS01265	COG0789	Transcriptional regulator
D0Y51_RS01320	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D0Y51_RS01330	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D0Y51_RS01335	COG0006	proline dipeptidase activity
D0Y51_RS01340	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D0Y51_RS01345	COG1302	Protein conserved in bacteria
D0Y51_RS01350	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D0Y51_RS01355	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D0Y51_RS01360	COG1570	exodeoxyribonuclease VII activity
D0Y51_RS01365	COG1722	exodeoxyribonuclease VII activity
D0Y51_RS01370	COG0142	geranyltranstransferase activity
D0Y51_RS01375	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
D0Y51_RS01380	COG1438	arginine binding
D0Y51_RS01385	COG0497	DNA recombination
D0Y51_RS01400	COG1732	Glycine betaine
D0Y51_RS01415	COG0194	GDP metabolic process
D0Y51_RS01420	COG1758	RNA polymerase activity
D0Y51_RS01425	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D0Y51_RS01430	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D0Y51_RS01435	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D0Y51_RS01440	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D0Y51_RS01440	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D0Y51_RS01445	COG0631	protein serine/threonine phosphatase activity
D0Y51_RS01450	COG2815	serine threonine protein kinase
D0Y51_RS01450	COG0515	serine threonine protein kinase
D0Y51_RS01455	COG1162	GTPase activity
D0Y51_RS01460	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D0Y51_RS01465	COG1564	THIamine pyrophosphokinase
D0Y51_RS01475	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D0Y51_RS01480	COG1302	Protein conserved in bacteria
D0Y51_RS01485	COG1461	Dihydroxyacetone kinase
D0Y51_RS01490	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D0Y51_RS01495	COG0416	fatty acid biosynthetic process
D0Y51_RS01500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D0Y51_RS01505	COG0571	ribonuclease III activity
D0Y51_RS01510	COG1196	nuclear chromosome segregation
D0Y51_RS01515	COG0552	protein localization to endoplasmic reticulum
D0Y51_RS01520	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
D0Y51_RS01525	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D0Y51_RS01530	COG0228	four-way junction DNA binding
D0Y51_RS01535	COG1837	Belongs to the UPF0109 family
D0Y51_RS01540	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D0Y51_RS01545	COG0336	Belongs to the RNA methyltransferase TrmD family
D0Y51_RS01550	COG0335	large ribosomal subunit rRNA binding
D0Y51_RS01585	COG0512	Glutamine amidotransferase of anthranilate synthase
D0Y51_RS01585	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D0Y51_RS01590	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D0Y51_RS01595	COG0134	indole-3-glycerol-phosphate synthase activity
D0Y51_RS01600	COG0135	phosphoribosylanthranilate isomerase activity
D0Y51_RS01605	COG0133	tryptophan synthase activity
D0Y51_RS01610	COG0159	tryptophan synthase activity
D0Y51_RS01625	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0Y51_RS01635	COG1473	amidohydrolase
D0Y51_RS01640	COG1063	alcohol dehydrogenase
D0Y51_RS01650	COG0300	oxidoreductase activity
D0Y51_RS01660	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D0Y51_RS01665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D0Y51_RS01670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D0Y51_RS01675	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D0Y51_RS01680	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y51_RS01685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D0Y51_RS01700	COG0439	Biotin carboxylase
D0Y51_RS01715	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D0Y51_RS01725	COG1811	Na channel or pump
D0Y51_RS01730	COG0583	DNA-binding transcription factor activity
D0Y51_RS01735	COG1607	acyl-coa hydrolase
D0Y51_RS01740	COG1162	GTPase activity
D0Y51_RS01750	COG0477	Major facilitator Superfamily
D0Y51_RS01805	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D0Y51_RS01810	COG3397	chitin binding
D0Y51_RS01825	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
D0Y51_RS01835	COG3152	Membrane
D0Y51_RS01840	COG1597	lipid kinase activity
D0Y51_RS01855	COG2261	transglycosylase associated protein
D0Y51_RS01860	COG3237	CsbD-like
D0Y51_RS01875	COG1942	4-Oxalocrotonate Tautomerase
D0Y51_RS01915	COG0531	amino acid
D0Y51_RS01920	COG0561	phosphatase activity
D0Y51_RS01925	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D0Y51_RS01925	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
D0Y51_RS01945	COG2017	converts alpha-aldose to the beta-anomer
D0Y51_RS01950	COG1304	FMN binding
D0Y51_RS01975	COG1199	ATP-dependent helicase activity
D0Y51_RS01975	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D0Y51_RS01990	COG0017	Asparaginyl-tRNA synthetase
D0Y51_RS02005	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D0Y51_RS02010	COG2011	ABC-type metal ion transport system permease component
D0Y51_RS02015	COG1464	Belongs to the NlpA lipoprotein family
D0Y51_RS02025	COG1177	transmembrane transport
D0Y51_RS02030	COG1840	ABC-type Fe3 transport system, periplasmic component
D0Y51_RS02045	COG3331	DNA recombination
D0Y51_RS02050	COG4474	Belongs to the UPF0398 family
D0Y51_RS02055	COG3599	regulation of cell shape
D0Y51_RS02065	COG0116	Belongs to the methyltransferase superfamily
D0Y51_RS02075	COG0477	Major facilitator Superfamily
D0Y51_RS02080	COG1073	alpha beta
D0Y51_RS02090	COG1216	Glycosyl transferase, family 2
D0Y51_RS02110	COG1619	proteins homologs of microcin C7 resistance protein MccF
D0Y51_RS02140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D0Y51_RS02155	COG2759	Belongs to the formate--tetrahydrofolate ligase family
D0Y51_RS02160	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D0Y51_RS02165	COG0564	pseudouridine synthase activity
D0Y51_RS02170	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D0Y51_RS02175	COG0505	Belongs to the CarA family
D0Y51_RS02180	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D0Y51_RS02195	COG5646	InterPro IPR014922
D0Y51_RS02230	COG1293	RNA-binding protein homologous to eukaryotic snRNP
D0Y51_RS02240	COG1307	EDD domain protein, DegV family
D0Y51_RS02300	COG1113	amino acid transport
D0Y51_RS02315	COG1620	l-lactate permease
D0Y51_RS02325	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D0Y51_RS02350	COG1846	Transcriptional regulator
D0Y51_RS02355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D0Y51_RS02395	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D0Y51_RS02400	COG1227	inorganic diphosphatase activity
D0Y51_RS02405	COG0583	DNA-binding transcription factor activity
D0Y51_RS02415	COG0187	DNA topoisomerase II activity
D0Y51_RS02420	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D0Y51_RS02430	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D0Y51_RS02435	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D0Y51_RS02440	COG4974	Belongs to the 'phage' integrase family
D0Y51_RS02445	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
D0Y51_RS02450	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D0Y51_RS02455	COG0758	DNA mediated transformation
D0Y51_RS02460	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D0Y51_RS02465	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D0Y51_RS02475	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D0Y51_RS02480	COG0583	DNA-binding transcription factor activity
D0Y51_RS02500	COG2814	Major facilitator Superfamily
D0Y51_RS02505	COG0793	Belongs to the peptidase S41A family
D0Y51_RS02505	COG3409	Peptidoglycan-binding domain 1 protein
D0Y51_RS02510	COG4479	Belongs to the UPF0346 family
D0Y51_RS02515	COG4698	Protein conserved in bacteria
D0Y51_RS02520	COG2755	lipolytic protein G-D-S-L family
D0Y51_RS02525	COG1307	EDD domain protein, DegV family
D0Y51_RS02530	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D0Y51_RS02535	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D0Y51_RS02540	COG0488	(ABC) transporter
D0Y51_RS02550	COG0617	tRNA 3'-terminal CCA addition
D0Y51_RS02555	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D0Y51_RS02560	COG0561	phosphatase activity
D0Y51_RS02565	COG0457	Tetratricopeptide repeat
D0Y51_RS02580	COG1160	GTP binding
D0Y51_RS02585	COG0539	negative regulation of cytoplasmic translation
D0Y51_RS02590	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D0Y51_RS02600	COG0514	ATP-dependent DNA helicase (RecQ)
D0Y51_RS02610	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
D0Y51_RS02615	COG1187	pseudouridine synthase activity
D0Y51_RS02620	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D0Y51_RS02625	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D0Y51_RS02635	COG4974	Belongs to the 'phage' integrase family
D0Y51_RS02640	COG2996	Protein conserved in bacteria
D0Y51_RS02655	COG0205	6-phosphofructokinase activity
D0Y51_RS02660	COG0587	DNA-directed DNA polymerase activity
D0Y51_RS02670	COG0542	response to heat
D0Y51_RS02680	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D0Y51_RS02685	COG2384	SAM-dependent methyltransferase
D0Y51_RS02710	COG0574	Belongs to the PEP-utilizing enzyme family
D0Y51_RS02710	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D0Y51_RS02720	COG1846	Transcriptional regulator
D0Y51_RS02740	COG2217	Heavy metal translocating P-type atpase
D0Y51_RS02745	COG0148	phosphopyruvate hydratase activity
D0Y51_RS02750	COG0477	Major facilitator Superfamily
D0Y51_RS02760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D0Y51_RS02770	COG0446	pyridine nucleotide-disulphide oxidoreductase
D0Y51_RS02775	COG1349	DNA-binding transcription factor activity
D0Y51_RS02785	COG1393	Belongs to the ArsC family
D0Y51_RS02830	COG0546	phosphoglycolate phosphatase activity
D0Y51_RS02860	COG0583	DNA-binding transcription factor activity
D0Y51_RS02865	COG0604	alcohol dehydrogenase
D0Y51_RS02875	COG0446	pyridine nucleotide-disulphide oxidoreductase
D0Y51_RS02880	COG2197	response regulator
D0Y51_RS02885	COG4585	Histidine kinase
D0Y51_RS02895	COG1131	(ABC) transporter
D0Y51_RS02905	COG0519	Catalyzes the synthesis of GMP from XMP
D0Y51_RS02935	COG1131	(ABC) transporter
D0Y51_RS02955	COG1131	(ABC) transporter
D0Y51_RS02960	COG1725	Transcriptional regulator
D0Y51_RS02970	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D0Y51_RS02975	COG0358	DNA primase activity
D0Y51_RS02980	COG0751	glycine-tRNA ligase activity
D0Y51_RS02985	COG0752	glycyl-tRNA synthetase alpha subunit
D0Y51_RS02990	COG1381	Involved in DNA repair and RecF pathway recombination
D0Y51_RS02995	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D0Y51_RS03000	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D0Y51_RS03005	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D0Y51_RS03010	COG1702	phosphate starvation-inducible protein PhoH
D0Y51_RS03015	COG1610	YqeY-like protein
D0Y51_RS03020	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D0Y51_RS03025	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D0Y51_RS03035	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
D0Y51_RS03045	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D0Y51_RS03055	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D0Y51_RS03060	COG0124	histidyl-tRNA synthetase
D0Y51_RS03065	COG3103	Sh3 type 3 domain protein
D0Y51_RS03065	COG4991	sh3 domain protein
D0Y51_RS03065	COG0860	N-Acetylmuramoyl-L-alanine amidase
D0Y51_RS03070	COG3001	Fructosamine kinase
D0Y51_RS03075	COG0546	phosphoglycolate phosphatase activity
D0Y51_RS03080	COG1490	D-aminoacyl-tRNA deacylase activity
D0Y51_RS03085	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D0Y51_RS03095	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D0Y51_RS03100	COG2264	protein methyltransferase activity
D0Y51_RS03105	COG2094	Belongs to the DNA glycosylase MPG family
D0Y51_RS03120	COG0481	GTPase activity
D0Y51_RS03125	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
D0Y51_RS03130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D0Y51_RS03135	COG1696	Membrane protein involved in D-alanine export
D0Y51_RS03140	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D0Y51_RS03150	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D0Y51_RS03155	COG0484	heat shock protein binding
D0Y51_RS03160	COG0443	Heat shock 70 kDa protein
D0Y51_RS03165	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D0Y51_RS03170	COG1420	regulation of RNA biosynthetic process
D0Y51_RS03175	COG3527	Alpha-acetolactate decarboxylase
D0Y51_RS03180	COG0196	riboflavin kinase activity
D0Y51_RS03185	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D0Y51_RS03190	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D0Y51_RS03195	COG0287	Prephenate dehydrogenase
D0Y51_RS03200	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D0Y51_RS03210	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D0Y51_RS03215	COG0738	Major facilitator superfamily
D0Y51_RS03220	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D0Y51_RS03225	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D0Y51_RS03235	COG2740	Nucleic-acid-binding protein implicated in transcription termination
D0Y51_RS03240	COG0195	Participates in both transcription termination and antitermination
D0Y51_RS03245	COG0779	Required for maturation of 30S ribosomal subunits
D0Y51_RS03250	COG2176	DNA-directed DNA polymerase activity
D0Y51_RS03255	COG0442	prolyl-tRNA aminoacylation
D0Y51_RS03260	COG0750	zinc metalloprotease
D0Y51_RS03265	COG4589	Belongs to the CDS family
D0Y51_RS03270	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D0Y51_RS03275	COG0233	cytoplasmic translational termination
D0Y51_RS03280	COG0528	UMP kinase activity
D0Y51_RS03285	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D0Y51_RS03290	COG0052	Belongs to the universal ribosomal protein uS2 family
D0Y51_RS03300	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D0Y51_RS03305	COG2827	Endonuclease containing a URI domain
D0Y51_RS03310	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D0Y51_RS03315	COG0204	Acyl-transferase
D0Y51_RS03320	COG3763	UPF0154 protein
D0Y51_RS03325	COG4224	UPF0291 protein
D0Y51_RS03330	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D0Y51_RS03345	COG3425	synthase
D0Y51_RS03360	COG0463	Glycosyl transferase, family 2
D0Y51_RS03430	COG0393	Putative heavy-metal-binding
D0Y51_RS03445	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D0Y51_RS03450	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D0Y51_RS03450	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D0Y51_RS03455	COG5416	Lipopolysaccharide assembly protein A domain
D0Y51_RS03460	COG0300	oxidoreductase activity
D0Y51_RS03465	COG1234	tRNA 3'-trailer cleavage
D0Y51_RS03475	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D0Y51_RS03480	COG1349	DNA-binding transcription factor activity
D0Y51_RS03485	COG1105	Belongs to the carbohydrate kinase PfkB family
D0Y51_RS03490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0Y51_RS03490	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0Y51_RS03490	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0Y51_RS03495	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D0Y51_RS03520	COG0297	glycogen (starch) synthase activity
D0Y51_RS03525	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D0Y51_RS03530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D0Y51_RS03540	COG0489	protein tyrosine kinase activity
D0Y51_RS03550	COG0322	excinuclease ABC activity
D0Y51_RS03555	COG1126	abc transporter atp-binding protein
D0Y51_RS03560	COG0765	amino acid transport
D0Y51_RS03580	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D0Y51_RS03585	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D0Y51_RS03590	COG0544	peptidyl-prolyl cis-trans isomerase activity
D0Y51_RS03595	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D0Y51_RS03620	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D0Y51_RS03625	COG0268	Binds directly to 16S ribosomal RNA
D0Y51_RS03630	COG1466	dna polymerase III delta subunit
D0Y51_RS03635	COG0658	competence protein
D0Y51_RS03635	COG2333	competence protein COMEC
D0Y51_RS03640	COG2131	deaminase
D0Y51_RS03645	COG1555	photosystem II stabilization
D0Y51_RS03645	COG1596	polysaccharide export
D0Y51_RS03650	COG3480	Lon protease (S16) C-terminal proteolytic domain
D0Y51_RS03655	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D0Y51_RS03660	COG0742	ribosomal rna small subunit methyltransferase
D0Y51_RS03665	COG4471	UPF0298 protein
D0Y51_RS03670	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
D0Y51_RS03675	COG0772	Belongs to the SEDS family
D0Y51_RS03710	COG1217	gtp-binding protein TYPA
D0Y51_RS03715	COG0483	inositol monophosphate 1-phosphatase activity
D0Y51_RS03720	COG4476	Belongs to the UPF0223 family
D0Y51_RS03725	COG0039	L-malate dehydrogenase activity
D0Y51_RS03750	COG0242	peptide deformylase activity
D0Y51_RS03760	COG5503	Protein of unknown function (DUF1447)
D0Y51_RS03765	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D0Y51_RS03770	COG1597	lipid kinase activity
D0Y51_RS03785	COG1388	LysM domain
D0Y51_RS03785	COG3584	3D domain protein
D0Y51_RS03795	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D0Y51_RS03800	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D0Y51_RS03830	COG0569	domain protein
D0Y51_RS03835	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D0Y51_RS03840	COG0482	sulfurtransferase activity
D0Y51_RS03850	COG1104	cysteine desulfurase activity
D0Y51_RS03855	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D0Y51_RS03865	COG0494	nUDIX hydrolase
D0Y51_RS03870	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D0Y51_RS03875	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D0Y51_RS03880	COG3599	regulation of cell shape
D0Y51_RS03890	COG0762	integral membrane protein
D0Y51_RS03895	COG1799	cell septum assembly
D0Y51_RS03910	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D0Y51_RS03915	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D0Y51_RS03920	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D0Y51_RS03925	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D0Y51_RS03930	COG0768	penicillin binding
D0Y51_RS03940	COG0275	rRNA processing
D0Y51_RS03945	COG2001	Belongs to the MraZ family
D0Y51_RS03965	COG1674	ftsk spoiiie
D0Y51_RS03970	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D0Y51_RS03980	COG1114	Component of the transport system for branched-chain amino acids
D0Y51_RS03990	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D0Y51_RS03995	COG0628	permease
D0Y51_RS04005	COG2706	6-phosphogluconolactonase activity
D0Y51_RS04010	COG3142	Participates in the control of copper homeostasis
D0Y51_RS04015	COG0564	pseudouridine synthase activity
D0Y51_RS04020	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D0Y51_RS04025	COG2357	RelA SpoT domain protein
D0Y51_RS04035	COG1164	Oligoendopeptidase f
D0Y51_RS04045	COG4862	establishment of competence for transformation
D0Y51_RS04050	COG1393	Belongs to the ArsC family
D0Y51_RS04055	COG1234	tRNA 3'-trailer cleavage
D0Y51_RS04195	COG1098	S1 RNA binding domain
D0Y51_RS04205	COG0586	Pfam SNARE associated Golgi protein
D0Y51_RS04215	COG0647	UMP catabolic process
D0Y51_RS04220	COG4470	Protein conserved in bacteria
D0Y51_RS04225	COG0737	Belongs to the 5'-nucleotidase family
D0Y51_RS04240	COG1113	amino acid transport
D0Y51_RS04245	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D0Y51_RS04250	COG0827	DNA restriction-modification system
D0Y51_RS04280	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D0Y51_RS04290	COG0217	transcriptional regulatory protein
D0Y51_RS04305	COG1609	Transcriptional regulator
D0Y51_RS04310	COG0006	proline dipeptidase activity
D0Y51_RS04315	COG0789	Transcriptional regulator
D0Y51_RS04330	COG0668	transmembrane transport
D0Y51_RS04335	COG1473	amidohydrolase
D0Y51_RS04340	COG2171	N-acyltransferase activity
D0Y51_RS04345	COG0517	IMP dehydrogenase activity
D0Y51_RS04355	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D0Y51_RS04360	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D0Y51_RS04365	COG1719	4-vinyl reductase, 4VR
D0Y51_RS04370	COG3118	belongs to the thioredoxin family
D0Y51_RS04375	COG1193	negative regulation of DNA recombination
D0Y51_RS04385	COG3906	Belongs to the UPF0473 family
D0Y51_RS04390	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D0Y51_RS04395	COG4472	Bacterial protein of unknown function (DUF965)
D0Y51_RS04400	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D0Y51_RS04405	COG0513	Belongs to the DEAD box helicase family
D0Y51_RS04410	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D0Y51_RS04415	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D0Y51_RS04420	COG1862	Preprotein translocase
D0Y51_RS04425	COG0343	queuine tRNA-ribosyltransferase activity
D0Y51_RS04430	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D0Y51_RS04435	COG2255	four-way junction helicase activity
D0Y51_RS04440	COG0632	four-way junction helicase activity
D0Y51_RS04470	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D0Y51_RS04475	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D0Y51_RS04480	COG1692	metallophosphoesterase
D0Y51_RS04485	COG1418	mRNA catabolic process
D0Y51_RS04490	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D0Y51_RS04495	COG1058	Belongs to the CinA family
D0Y51_RS04495	COG1546	Belongs to the CinA family
D0Y51_RS04500	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D0Y51_RS04505	COG1426	Protein conserved in bacteria
D0Y51_RS04510	COG0612	Peptidase, M16
D0Y51_RS04515	COG0612	Peptidase, M16
D0Y51_RS04520	COG0527	aspartate kinase activity
D0Y51_RS04530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0Y51_RS04535	COG1126	abc transporter atp-binding protein
D0Y51_RS04540	COG0765	amino acid transport
D0Y51_RS04545	COG2894	cell division
D0Y51_RS04550	COG0850	regulation of cytokinetic process
D0Y51_RS04560	COG1792	Involved in formation and maintenance of cell shape
D0Y51_RS04565	COG1077	Cell shape determining protein MreB Mrl
D0Y51_RS04570	COG2003	Belongs to the UPF0758 family
D0Y51_RS04575	COG0285	dihydrofolate synthase activity
D0Y51_RS04580	COG0525	valine-tRNA ligase activity
D0Y51_RS04595	COG0301	tRNA thio-modification
D0Y51_RS04600	COG1104	cysteine desulfurase activity
D0Y51_RS04610	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
D0Y51_RS04615	COG1956	GAF domain-containing protein
D0Y51_RS04620	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D0Y51_RS04625	COG4493	Belongs to the UPF0637 family
D0Y51_RS04640	COG0640	Transcriptional regulator
D0Y51_RS04645	COG0366	Alpha amylase catalytic
D0Y51_RS04655	COG3716	PTS system mannose fructose sorbose family IID component
D0Y51_RS04660	COG3715	PTS system
D0Y51_RS04665	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0Y51_RS04670	COG1609	Transcriptional regulator
D0Y51_RS04675	COG2918	glutathione biosynthetic process
D0Y51_RS04675	COG0189	ligase activity
D0Y51_RS04680	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D0Y51_RS04695	COG0589	response to stress
D0Y51_RS04715	COG1181	Belongs to the D-alanine--D-alanine ligase family
D0Y51_RS04735	COG1464	Belongs to the NlpA lipoprotein family
D0Y51_RS04740	COG2011	ABC-type metal ion transport system permease component
D0Y51_RS04745	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D0Y51_RS04750	COG0509	glycine decarboxylation via glycine cleavage system
D0Y51_RS04755	COG0772	Belongs to the SEDS family
D0Y51_RS04765	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D0Y51_RS04770	COG1077	Cell shape determining protein MreB Mrl
D0Y51_RS04780	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D0Y51_RS04785	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D0Y51_RS04790	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D0Y51_RS04795	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D0Y51_RS04800	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D0Y51_RS04805	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D0Y51_RS04810	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D0Y51_RS04815	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D0Y51_RS04820	COG0356	it plays a direct role in the translocation of protons across the membrane
D0Y51_RS04825	COG2233	PERMEase
D0Y51_RS04835	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D0Y51_RS04840	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D0Y51_RS04845	COG0009	L-threonylcarbamoyladenylate synthase
D0Y51_RS04850	COG2890	protein-(glutamine-N5) methyltransferase activity
D0Y51_RS04855	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D0Y51_RS04860	COG1435	thymidine kinase activity
D0Y51_RS04865	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D0Y51_RS04870	COG3442	glutamine amidotransferase
D0Y51_RS04875	COG1482	cell wall glycoprotein biosynthetic process
D0Y51_RS04880	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D0Y51_RS04890	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D0Y51_RS04905	COG1132	(ABC) transporter
D0Y51_RS04920	COG0726	polysaccharide deacetylase
D0Y51_RS05185	COG1396	sequence-specific DNA binding
D0Y51_RS05230	COG0513	Belongs to the DEAD box helicase family
D0Y51_RS05235	COG0673	inositol 2-dehydrogenase activity
D0Y51_RS05240	COG1278	Cold shock
D0Y51_RS05255	COG1737	Transcriptional regulator
D0Y51_RS05265	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0Y51_RS05280	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D0Y51_RS05285	COG1597	lipid kinase activity
D0Y51_RS05290	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D0Y51_RS05295	COG0154	amidase activity
D0Y51_RS05300	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D0Y51_RS05305	COG4851	CamS sex pheromone cAM373 precursor
D0Y51_RS05310	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D0Y51_RS05320	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D0Y51_RS05325	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
D0Y51_RS05330	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D0Y51_RS05335	COG1705	Flagellar rod assembly protein muramidase FlgJ
D0Y51_RS05365	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D0Y51_RS05370	COG4988	ABC transporter
D0Y51_RS05375	COG1294	oxidase, subunit
D0Y51_RS05380	COG1271	oxidase subunit
D0Y51_RS05395	COG4684	Psort location CytoplasmicMembrane, score
D0Y51_RS05400	COG0531	amino acid
D0Y51_RS05410	COG0281	malic enzyme
D0Y51_RS05415	COG0583	DNA-binding transcription factor activity
D0Y51_RS05420	COG0583	DNA-binding transcription factor activity
D0Y51_RS05430	COG1053	succinate dehydrogenase
D0Y51_RS05435	COG0114	fumarate hydratase activity
D0Y51_RS05475	COG3052	prosthetic group binding
D0Y51_RS05495	COG0471	metal ion transport
D0Y51_RS05500	COG0039	L-malate dehydrogenase activity
D0Y51_RS05510	COG0803	Belongs to the bacterial solute-binding protein 9 family
D0Y51_RS05515	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D0Y51_RS05520	COG1121	(ABC) transporter
D0Y51_RS05525	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
D0Y51_RS05530	COG4977	sequence-specific DNA binding
D0Y51_RS05530	COG1917	Cupin 2, conserved barrel domain protein
D0Y51_RS05540	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D0Y51_RS05545	COG2151	metal-sulfur cluster biosynthetic enzyme
D0Y51_RS05550	COG0471	metal ion transport
D0Y51_RS05560	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
D0Y51_RS05565	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D0Y51_RS05570	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D0Y51_RS05590	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D0Y51_RS05595	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D0Y51_RS05600	COG0101	tRNA pseudouridine synthase activity
D0Y51_RS05610	COG1122	ATPase activity
D0Y51_RS05615	COG1122	ATPase activity
D0Y51_RS05625	COG4939	FMN-binding domain protein
D0Y51_RS05650	COG0203	ribosomal protein L17
D0Y51_RS05655	COG0202	RNA polymerase activity
D0Y51_RS05660	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D0Y51_RS05665	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D0Y51_RS05670	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D0Y51_RS05675	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D0Y51_RS05680	COG0563	adenylate kinase activity
D0Y51_RS05690	COG0200	Binds to the 23S rRNA
D0Y51_RS05695	COG1841	ribosomal large subunit assembly
D0Y51_RS05700	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D0Y51_RS05705	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D0Y51_RS05710	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D0Y51_RS05715	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D0Y51_RS05720	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D0Y51_RS05725	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D0Y51_RS05730	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D0Y51_RS05735	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D0Y51_RS05740	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D0Y51_RS05745	COG0255	Belongs to the universal ribosomal protein uL29 family
D0Y51_RS05750	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D0Y51_RS05755	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D0Y51_RS05760	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D0Y51_RS05765	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D0Y51_RS05770	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D0Y51_RS05775	COG0089	rRNA binding
D0Y51_RS05780	COG0088	Forms part of the polypeptide exit tunnel
D0Y51_RS05785	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D0Y51_RS05790	COG0051	transcription antitermination factor activity, RNA binding
D0Y51_RS05795	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D0Y51_RS05800	COG0049	tRNA binding
D0Y51_RS05805	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D0Y51_RS05810	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
D0Y51_RS05815	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D0Y51_RS05820	COG0085	RNA polymerase activity
D0Y51_RS05830	COG0542	response to heat
D0Y51_RS05835	COG4463	regulation of RNA biosynthetic process
D0Y51_RS05875	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D0Y51_RS05880	COG1428	Deoxynucleoside kinase
D0Y51_RS05890	COG0833	amino acid
D0Y51_RS05895	COG0028	Belongs to the TPP enzyme family
D0Y51_RS05900	COG1959	2 iron, 2 sulfur cluster binding
D0Y51_RS05920	COG1316	TRANSCRIPTIONal
D0Y51_RS05930	COG2966	Psort location CytoplasmicMembrane, score
D0Y51_RS05935	COG1278	Cold shock
D0Y51_RS05955	COG2814	Major facilitator Superfamily
D0Y51_RS06005	COG0367	asparagine synthase
D0Y51_RS06010	COG0527	aspartate kinase activity
D0Y51_RS06015	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D0Y51_RS06065	COG0640	Transcriptional regulator
D0Y51_RS06070	COG0564	pseudouridine synthase activity
D0Y51_RS06075	COG0514	ATP-dependent DNA helicase (RecQ)
D0Y51_RS06095	COG4690	dipeptidase activity
D0Y51_RS06100	COG2502	aspartate--ammonia ligase
D0Y51_RS06105	COG0017	Asparaginyl-tRNA synthetase
D0Y51_RS06110	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D0Y51_RS06120	COG1053	succinate dehydrogenase
D0Y51_RS06125	COG0583	DNA-binding transcription factor activity
D0Y51_RS06140	COG0572	uridine kinase
D0Y51_RS06170	COG0308	aminopeptidase N
D0Y51_RS06200	COG1302	Protein conserved in bacteria
D0Y51_RS06215	COG2261	transglycosylase associated protein
D0Y51_RS06220	COG2755	lipolytic protein G-D-S-L family
D0Y51_RS06220	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D0Y51_RS06235	COG2814	Major facilitator Superfamily
D0Y51_RS06240	COG1733	regulation of RNA biosynthetic process
D0Y51_RS06245	COG1266	CAAX protease self-immunity
D0Y51_RS06250	COG1396	sequence-specific DNA binding
D0Y51_RS06280	COG0464	growth
D0Y51_RS06285	COG0519	Catalyzes the synthesis of GMP from XMP
D0Y51_RS06285	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D0Y51_RS06290	COG1072	(Pantothenic acid kinase))
D0Y51_RS06295	COG2070	2-Nitropropane dioxygenase
D0Y51_RS06300	COG3973	AAA domain
D0Y51_RS06305	COG0586	Pfam SNARE associated Golgi protein
D0Y51_RS06310	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
D0Y51_RS06310	COG0456	acetyltransferase
D0Y51_RS06315	COG0569	domain protein
D0Y51_RS06315	COG0475	glutathione-regulated potassium exporter activity
D0Y51_RS06320	COG0588	phosphoglycerate mutase activity
D0Y51_RS06335	COG2076	Multidrug Resistance protein
D0Y51_RS06345	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D0Y51_RS06375	COG1846	Transcriptional regulator
D0Y51_RS06385	COG0531	amino acid
D0Y51_RS06390	COG3394	polysaccharide catabolic process
D0Y51_RS06395	COG1263	PTS System
D0Y51_RS06395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0Y51_RS06405	COG1263	PTS System
D0Y51_RS06405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0Y51_RS06405	COG2190	(PTS) system
D0Y51_RS06410	COG0765	amino acid transport
D0Y51_RS06415	COG0765	amino acid transport
D0Y51_RS06420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0Y51_RS06440	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D0Y51_RS06445	COG0436	Aminotransferase
D0Y51_RS06450	COG0546	phosphoglycolate phosphatase activity
D0Y51_RS06465	COG0735	belongs to the Fur family
D0Y51_RS06470	COG0194	GDP metabolic process
D0Y51_RS06495	COG0531	amino acid
D0Y51_RS06510	COG2936	dipeptidyl-peptidase activity
D0Y51_RS06515	COG2755	lipolytic protein G-D-S-L family
D0Y51_RS06515	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D0Y51_RS06525	COG2267	carboxylic ester hydrolase activity
D0Y51_RS06530	COG0028	Belongs to the TPP enzyme family
D0Y51_RS06535	COG0196	riboflavin kinase activity
D0Y51_RS06540	COG0028	Belongs to the TPP enzyme family
D0Y51_RS06545	COG2252	PERMEase
D0Y51_RS06560	COG3475	LICD family
D0Y51_RS06570	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D0Y51_RS06580	COG0477	Major facilitator Superfamily
D0Y51_RS06595	COG1393	Belongs to the ArsC family
D0Y51_RS06610	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D0Y51_RS06630	COG0778	Nitroreductase
D0Y51_RS06645	COG2017	converts alpha-aldose to the beta-anomer
D0Y51_RS06655	COG0561	phosphatase activity
D0Y51_RS06665	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D0Y51_RS06670	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D0Y51_RS06695	COG0025	NhaP-type Na H and K H
D0Y51_RS06700	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D0Y51_RS06710	COG0708	Exodeoxyribonuclease III
D0Y51_RS06725	COG0802	atpase or kinase
D0Y51_RS06730	COG0280	phosphate acetyltransferase
D0Y51_RS06735	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D0Y51_RS06740	COG0561	phosphatase activity
D0Y51_RS06750	COG1126	abc transporter atp-binding protein
D0Y51_RS06755	COG0765	amino acid transport
D0Y51_RS06765	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D0Y51_RS06770	COG0557	exoribonuclease II activity
D0Y51_RS06780	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D0Y51_RS06785	COG0038	chloride channel
D0Y51_RS06800	COG0148	phosphopyruvate hydratase activity
D0Y51_RS06805	COG0149	triose-phosphate isomerase activity
D0Y51_RS06810	COG0126	phosphoglycerate kinase activity
D0Y51_RS06820	COG2390	Transcriptional regulator
D0Y51_RS06825	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D0Y51_RS06835	COG0740	serine-type endopeptidase activity
D0Y51_RS06840	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D0Y51_RS06850	COG1481	regulation of sporulation
D0Y51_RS06860	COG1660	Displays ATPase and GTPase activities
D0Y51_RS06870	COG0165	Argininosuccinate lyase
D0Y51_RS06875	COG0137	argininosuccinate synthase activity
D0Y51_RS06880	COG1854	S-ribosylhomocysteine lyase activity
D0Y51_RS06885	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D0Y51_RS06890	COG0556	nucleotide-excision repair
D0Y51_RS06900	COG2814	Major facilitator Superfamily
D0Y51_RS06910	COG0446	pyridine nucleotide-disulphide oxidoreductase
D0Y51_RS06920	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D0Y51_RS06930	COG2323	membrane
D0Y51_RS06935	COG0492	ferredoxin-NADP+ reductase activity
D0Y51_RS06950	COG1215	transferase activity, transferring glycosyl groups
D0Y51_RS06970	COG0446	pyridine nucleotide-disulphide oxidoreductase
D0Y51_RS06980	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D0Y51_RS06985	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D0Y51_RS06990	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D0Y51_RS06995	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
D0Y51_RS07000	COG1950	PFAM Membrane protein of
D0Y51_RS07005	COG1983	PspC domain protein
D0Y51_RS07010	COG0704	Plays a role in the regulation of phosphate uptake
D0Y51_RS07015	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D0Y51_RS07020	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D0Y51_RS07025	COG0581	inorganic phosphate transmembrane transporter activity
D0Y51_RS07030	COG0573	inorganic phosphate transmembrane transporter activity
D0Y51_RS07035	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D0Y51_RS07040	COG5002	protein histidine kinase activity
D0Y51_RS07045	COG0745	RESPONSE REGULATOR receiver
D0Y51_RS07060	COG0653	protein targeting
D0Y51_RS07075	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
D0Y51_RS07080	COG1739	Uncharacterized protein family UPF0029
D0Y51_RS07085	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D0Y51_RS07090	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D0Y51_RS07095	COG0531	amino acid
D0Y51_RS07100	COG0459	protein refolding
D0Y51_RS07105	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D0Y51_RS07115	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
D0Y51_RS07120	COG0488	(ABC) transporter
D0Y51_RS07130	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D0Y51_RS07135	COG0456	acetyltransferase
D0Y51_RS07140	COG0456	acetyltransferase
D0Y51_RS07145	COG1214	PFAM Peptidase M22, glycoprotease
D0Y51_RS07155	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
D0Y51_RS07165	COG3639	organic phosphonate transmembrane transporter activity
D0Y51_RS07170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0Y51_RS07175	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D0Y51_RS07180	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D0Y51_RS07195	COG4467	Involved in initiation control of chromosome replication
D0Y51_RS07200	COG0470	DNA polymerase III
D0Y51_RS07205	COG3870	Protein conserved in bacteria
D0Y51_RS07210	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D0Y51_RS07250	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D0Y51_RS07255	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D0Y51_RS07260	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D0Y51_RS07275	COG2813	Specifically methylates the guanine in position
D0Y51_RS07280	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D0Y51_RS07285	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D0Y51_RS07295	COG1611	Belongs to the LOG family
D0Y51_RS07315	COG0222	ribosome binding
D0Y51_RS07320	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D0Y51_RS07325	COG0081	regulation of translation
D0Y51_RS07330	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D0Y51_RS07340	COG0250	Participates in transcription elongation, termination and antitermination
D0Y51_RS07350	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D0Y51_RS07365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D0Y51_RS07370	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
D0Y51_RS07375	COG0215	cysteine-tRNA ligase activity
D0Y51_RS07380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D0Y51_RS07385	COG4956	integral membrane protein (PIN domain superfamily)
D0Y51_RS07405	COG0756	dUTP diphosphatase activity
D0Y51_RS07415	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D0Y51_RS07430	COG0588	phosphoglycerate mutase activity
D0Y51_RS07435	COG0697	spore germination
D0Y51_RS07445	COG1316	TRANSCRIPTIONal
D0Y51_RS07450	COG0825	malonyl-CoA metabolic process
D0Y51_RS07460	COG0439	Biotin carboxylase
D0Y51_RS07470	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D0Y51_RS07475	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0Y51_RS07475	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0Y51_RS07480	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0Y51_RS07480	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0Y51_RS07485	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D0Y51_RS07485	COG3933	PFAM sigma-54 factor interaction domain-containing protein
D0Y51_RS07495	COG3716	PTS system mannose fructose sorbose family IID component
D0Y51_RS07500	COG3715	PTS system
D0Y51_RS07520	COG0083	homoserine kinase activity
D0Y51_RS07525	COG0460	homoserine dehydrogenase
D0Y51_RS07530	COG3091	SprT-like family
D0Y51_RS07535	COG2183	response to ionizing radiation
D0Y51_RS07550	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D0Y51_RS07555	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D0Y51_RS07565	COG2188	Transcriptional regulator
D0Y51_RS07575	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D0Y51_RS07625	COG3104	oligopeptide transport
D0Y51_RS07665	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D0Y51_RS07670	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D0Y51_RS07675	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D0Y51_RS07690	COG0037	tRNA processing
D0Y51_RS07695	COG1098	S1 RNA binding domain
D0Y51_RS07705	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D0Y51_RS07710	COG2244	polysaccharide biosynthetic process
D0Y51_RS07715	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D0Y51_RS07720	COG0193	aminoacyl-tRNA hydrolase activity
D0Y51_RS07725	COG0039	L-malate dehydrogenase activity
D0Y51_RS07745	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D0Y51_RS07750	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D0Y51_RS07755	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D0Y51_RS07760	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D0Y51_RS07765	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D0Y51_RS07770	COG0505	Belongs to the CarA family
D0Y51_RS07775	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D0Y51_RS07795	COG3158	transport of potassium into the cell
D0Y51_RS07800	COG2337	Toxic component of a toxin-antitoxin (TA) module
D0Y51_RS07805	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D0Y51_RS07810	COG0736	holo-[acyl-carrier-protein] synthase activity
D0Y51_RS07830	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D0Y51_RS07840	COG0501	Belongs to the peptidase M48B family
D0Y51_RS07845	COG1704	LemA family
D0Y51_RS07850	COG3764	Sortase (surface protein transpeptidase)
D0Y51_RS07860	COG0254	rRNA binding
D0Y51_RS07865	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D0Y51_RS07870	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D0Y51_RS07885	COG1760	l-serine dehydratase
D0Y51_RS07890	COG1760	l-serine dehydratase
D0Y51_RS07900	COG0814	amino acid
D0Y51_RS07905	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D0Y51_RS07910	COG0504	CTP synthase activity
D0Y51_RS07915	COG3343	RNA polymerase activity
D0Y51_RS07925	COG0095	Lipoate-protein ligase
D0Y51_RS07930	COG1078	dGTPase activity
D0Y51_RS07950	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D0Y51_RS07960	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D0Y51_RS07965	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D0Y51_RS07990	COG1321	iron dependent repressor
D0Y51_RS07990	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D0Y51_RS07995	COG1121	(ABC) transporter
D0Y51_RS08000	COG1073	alpha beta
D0Y51_RS08005	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D0Y51_RS08010	COG4466	Protein conserved in bacteria
D0Y51_RS08015	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D0Y51_RS08020	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
D0Y51_RS08025	COG0084	hydrolase, TatD family'
D0Y51_RS08030	COG2814	Major facilitator Superfamily
D0Y51_RS08035	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D0Y51_RS08035	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D0Y51_RS08045	COG1801	Protein of unknown function DUF72
D0Y51_RS08050	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D0Y51_RS08065	COG0248	Ppx GppA phosphatase
D0Y51_RS08080	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D0Y51_RS08090	COG1940	carbohydrate kinase activity
D0Y51_RS08095	COG2723	6-phospho-beta-galactosidase activity
D0Y51_RS08100	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0Y51_RS08115	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0Y51_RS08120	COG2188	Transcriptional regulator
D0Y51_RS08125	COG0180	Tryptophanyl-tRNA synthetase
D0Y51_RS08130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D0Y51_RS08135	COG3973	AAA domain
D0Y51_RS08170	COG2274	protein secretion by the type I secretion system
D0Y51_RS08195	COG3279	Response regulator of the LytR AlgR family
D0Y51_RS08220	COG0463	Glycosyl transferase, family 2
D0Y51_RS08265	COG1114	Component of the transport system for branched-chain amino acids
D0Y51_RS08270	COG0561	phosphatase activity
D0Y51_RS08280	COG0561	phosphatase activity
D0Y51_RS08290	COG0110	maltose O-acetyltransferase activity
D0Y51_RS08365	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D0Y51_RS08375	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D0Y51_RS08385	COG1125	glycine betaine transport
D0Y51_RS08405	COG0300	oxidoreductase activity
D0Y51_RS08435	COG1881	PFAM PEBP family protein
D0Y51_RS08440	COG3759	membrane
D0Y51_RS08450	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D0Y51_RS08470	COG0004	ammonium transporteR
D0Y51_RS08475	COG2814	Major facilitator Superfamily
D0Y51_RS08490	COG1134	teichoic acid transport
D0Y51_RS08495	COG1682	transport, permease protein
D0Y51_RS08505	COG0436	Aminotransferase
D0Y51_RS08510	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D0Y51_RS08515	COG2011	ABC-type metal ion transport system permease component
D0Y51_RS08540	COG1268	BioY protein
D0Y51_RS08575	COG1012	belongs to the aldehyde dehydrogenase family
D0Y51_RS08575	COG1454	alcohol dehydrogenase
D0Y51_RS08585	COG1131	(ABC) transporter
D0Y51_RS08590	COG1725	Transcriptional regulator
D0Y51_RS08620	COG3842	ATPase activity
D0Y51_RS08660	COG1252	NADH dehydrogenase
D0Y51_RS08665	COG1846	Transcriptional regulator
D0Y51_RS08675	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D0Y51_RS08705	COG1388	LysM domain
D0Y51_RS08705	COG3942	CHAP domain
D0Y51_RS08710	COG0741	lytic transglycosylase activity
D0Y51_RS08725	COG1136	(ABC) transporter
D0Y51_RS08730	COG0577	efflux transmembrane transporter activity
D0Y51_RS08740	COG2818	Glycosylase
D0Y51_RS08745	COG1033	growth of symbiont in host cell
D0Y51_RS08745	COG2409	Drug exporters of the RND superfamily
D0Y51_RS08755	COG2357	RelA SpoT domain protein
D0Y51_RS08765	COG0277	FAD linked oxidase domain protein
D0Y51_RS08770	COG1316	TRANSCRIPTIONal
D0Y51_RS08785	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0Y51_RS08790	COG1737	Transcriptional regulator
D0Y51_RS08800	COG0745	RESPONSE REGULATOR receiver
D0Y51_RS08805	COG5002	protein histidine kinase activity
D0Y51_RS08815	COG2814	Major facilitator Superfamily
D0Y51_RS08835	COG1914	H( )-stimulated, divalent metal cation uptake system
D0Y51_RS08840	COG1309	transcriptional regulator
D0Y51_RS08845	COG1959	2 iron, 2 sulfur cluster binding
D0Y51_RS08855	COG0163	prenyltransferase activity
D0Y51_RS08865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0Y51_RS08865	COG2190	(PTS) system
D0Y51_RS08865	COG1263	PTS System
D0Y51_RS08870	COG2190	(PTS) system
D0Y51_RS08870	COG1263	PTS System
D0Y51_RS08870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0Y51_RS08875	COG0366	Alpha amylase catalytic
D0Y51_RS08880	COG2188	Transcriptional regulator
D0Y51_RS08910	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D0Y51_RS08915	COG0626	cystathionine gamma-synthase activity
D0Y51_RS08920	COG1045	serine acetyltransferase
D0Y51_RS08925	COG0431	NADPH-dependent FMN reductase
D0Y51_RS08955	COG3118	belongs to the thioredoxin family
D0Y51_RS08965	COG0246	Mannitol dehydrogenase
D0Y51_RS08970	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0Y51_RS08980	COG2213	PTS system mannitol-specific
D0Y51_RS08995	COG1053	succinate dehydrogenase
D0Y51_RS08995	COG3976	FMN-binding domain protein
D0Y51_RS09005	COG0363	glucosamine-6-phosphate deaminase activity
D0Y51_RS09020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D0Y51_RS09030	COG0386	Belongs to the glutathione peroxidase family
D0Y51_RS09040	COG4172	Belongs to the ABC transporter superfamily
D0Y51_RS09055	COG0488	(ABC) transporter
D0Y51_RS09060	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D0Y51_RS09065	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D0Y51_RS09095	COG0667	Aldo Keto reductase
D0Y51_RS09100	COG0406	alpha-ribazole phosphatase activity
D0Y51_RS09105	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D0Y51_RS09110	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D0Y51_RS09120	COG4166	transmembrane transport
D0Y51_RS09125	COG4166	transmembrane transport
D0Y51_RS09150	COG1757	Na H antiporter
D0Y51_RS09200	COG3842	ATPase activity
D0Y51_RS09205	COG0366	Alpha amylase catalytic
D0Y51_RS09215	COG3833	ABC-type maltose transport systems, permease component
D0Y51_RS09220	COG1175	transmembrane transport
D0Y51_RS09225	COG2182	Extracellular solute-binding protein
D0Y51_RS09230	COG0366	Alpha amylase catalytic
D0Y51_RS09235	COG1609	Transcriptional regulator
D0Y51_RS09240	COG1609	Transcriptional regulator
D0Y51_RS09245	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D0Y51_RS09250	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
D0Y51_RS09255	COG1461	Dihydroxyacetone kinase
D0Y51_RS09260	COG2376	Dihydroxyacetone kinase
D0Y51_RS09265	COG2376	Dihydroxyacetone kinase
D0Y51_RS09270	COG1309	transcriptional regulator
D0Y51_RS09275	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
D0Y51_RS09280	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D0Y51_RS09295	COG1131	(ABC) transporter
D0Y51_RS09300	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y51_RS09325	COG2188	Transcriptional regulator
D0Y51_RS09335	COG4720	Psort location CytoplasmicMembrane, score
D0Y51_RS09340	COG1122	ATPase activity
D0Y51_RS09345	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D0Y51_RS09375	COG0667	Aldo Keto reductase
D0Y51_RS09380	COG0656	L-ascorbic acid biosynthetic process
D0Y51_RS09385	COG2807	transmembrane transport
D0Y51_RS09425	COG1983	PspC domain protein
D0Y51_RS09435	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D0Y51_RS09440	COG2267	carboxylic ester hydrolase activity
D0Y51_RS09450	COG1113	amino acid transport
D0Y51_RS09465	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D0Y51_RS09475	COG0352	thiamine-phosphate diphosphorylase activity
D0Y51_RS09480	COG0351	phosphomethylpyrimidine kinase
D0Y51_RS09485	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
D0Y51_RS09490	COG0604	alcohol dehydrogenase
D0Y51_RS09495	COG1606	tRNA processing
D0Y51_RS09500	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D0Y51_RS09505	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
D0Y51_RS09510	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
D0Y51_RS09515	COG1691	(AIR) carboxylase
D0Y51_RS09520	COG3875	lactate racemase activity
D0Y51_RS09525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D0Y51_RS09530	COG0310	cobalt ion transport
D0Y51_RS09535	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D0Y51_RS09540	COG1122	ATPase activity
D0Y51_RS09565	COG4166	transmembrane transport
D0Y51_RS09575	COG3022	response to hydroperoxide
D0Y51_RS09580	COG2267	carboxylic ester hydrolase activity
D0Y51_RS09605	COG0604	alcohol dehydrogenase
D0Y51_RS09640	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D0Y51_RS09660	COG2368	4-hydroxyphenylacetate
D0Y51_RS09665	COG2365	Tyrosine phosphatase family
D0Y51_RS09675	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
D0Y51_RS09680	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0Y51_RS09690	COG2508	Transcriptional regulator
D0Y51_RS09695	COG0778	Nitroreductase
D0Y51_RS09705	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y51_RS09710	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D0Y51_RS09725	COG0471	metal ion transport
D0Y51_RS09730	COG1053	succinate dehydrogenase
D0Y51_RS09730	COG3976	FMN-binding domain protein
D0Y51_RS09730	COG0431	NADPH-dependent FMN reductase
D0Y51_RS09750	COG1573	uracil-dna glycosylase
D0Y51_RS09760	COG1012	belongs to the aldehyde dehydrogenase family
D0Y51_RS09770	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D0Y51_RS09775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D0Y51_RS09780	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D0Y51_RS09785	COG4853	Protein conserved in bacteria
D0Y51_RS09795	COG5002	protein histidine kinase activity
D0Y51_RS09800	COG0745	RESPONSE REGULATOR receiver
D0Y51_RS09815	COG1278	Cold shock
D0Y51_RS09825	COG1554	hydrolase, family 65, central catalytic
D0Y51_RS09830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0Y51_RS09840	COG0366	Alpha amylase catalytic
D0Y51_RS09840	COG3103	Sh3 type 3 domain protein
D0Y51_RS09845	COG0058	SHG alpha-glucan phosphorylase activity
D0Y51_RS09850	COG0297	glycogen (starch) synthase activity
D0Y51_RS09855	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D0Y51_RS09860	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D0Y51_RS09865	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D0Y51_RS09875	COG4166	transmembrane transport
D0Y51_RS09880	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D0Y51_RS09885	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D0Y51_RS09890	COG2814	Major facilitator Superfamily
D0Y51_RS09895	COG0305	Participates in initiation and elongation during chromosome replication
D0Y51_RS09900	COG0359	binds to the 23S rRNA
D0Y51_RS09910	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D0Y51_RS09915	COG0629	single-stranded DNA binding
D0Y51_RS09920	COG0360	Binds together with S18 to 16S ribosomal RNA
D0Y51_RS09930	COG0187	DNA topoisomerase II activity
D0Y51_RS09935	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D0Y51_RS09940	COG2501	S4 domain
D0Y51_RS09945	COG0592	DNA-directed DNA polymerase activity
D0Y51_RS09950	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D0Y51_RS09955	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D0Y51_RS09960	COG0594	ribonuclease P activity
D0Y51_RS09965	COG0706	membrane insertase activity
D0Y51_RS09970	COG4166	transmembrane transport
D0Y51_RS09980	COG1847	R3H domain protein
D0Y51_RS09985	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D0Y51_RS09990	COG0445	tRNA wobble uridine modification
D0Y51_RS10030	COG1307	EDD domain protein, DegV family
D0Y51_RS10045	COG3479	Phenolic acid decarboxylase
D0Y51_RS10050	COG1695	Transcriptional regulator
D0Y51_RS10060	COG1454	alcohol dehydrogenase
D0Y51_RS10060	COG1012	belongs to the aldehyde dehydrogenase family
D0Y51_RS10065	COG1609	Transcriptional regulator
D0Y51_RS10075	COG1869	D-ribose catabolic process
D0Y51_RS10080	COG4975	Glucose uptake
D0Y51_RS10100	COG3730	PTS system glucitol sorbitol-specific
D0Y51_RS10105	COG3732	PTS system glucitol sorbitol-specific
D0Y51_RS10120	COG2188	Transcriptional regulator
D0Y51_RS10125	COG1132	(ABC) transporter
D0Y51_RS10130	COG1132	(ABC) transporter
D0Y51_RS10135	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D0Y51_RS10135	COG2207	Transcriptional regulator
D0Y51_RS10150	COG0395	ABC-type sugar transport system, permease component
D0Y51_RS10155	COG1653	transport
D0Y51_RS10160	COG0366	Alpha amylase catalytic
D0Y51_RS10170	COG2972	Histidine kinase
D0Y51_RS10175	COG2207	Transcriptional regulator
D0Y51_RS10175	COG4753	response regulator
D0Y51_RS10185	COG3842	ATPase activity
D0Y51_RS10195	COG2188	Transcriptional regulator
D0Y51_RS10205	COG0383	alpha-mannosidase activity
D0Y51_RS10210	COG1940	carbohydrate kinase activity
D0Y51_RS10215	COG2723	6-phospho-beta-galactosidase activity
D0Y51_RS10255	COG2207	Transcriptional regulator
D0Y51_RS10255	COG1609	Transcriptional regulator
D0Y51_RS10340	COG1349	DNA-binding transcription factor activity
D0Y51_RS10345	COG2207	Transcriptional regulator
D0Y51_RS10350	COG2814	Major facilitator Superfamily
D0Y51_RS10355	COG1070	Carbohydrate kinase
D0Y51_RS10360	COG3254	rhamnose metabolic process
D0Y51_RS10365	COG4806	L-rhamnose isomerase
D0Y51_RS10370	COG0235	Class ii aldolase
D0Y51_RS10385	COG0028	Belongs to the TPP enzyme family
D0Y51_RS10390	COG1959	2 iron, 2 sulfur cluster binding
D0Y51_RS10395	COG0028	Belongs to the TPP enzyme family
D0Y51_RS10400	COG1304	FMN binding
D0Y51_RS10415	COG4512	PFAM Accessory gene regulator B
D0Y51_RS10435	COG1393	Belongs to the ArsC family
D0Y51_RS10445	COG2261	transglycosylase associated protein
D0Y51_RS10475	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
D0Y51_RS10480	COG1609	Transcriptional regulator
D0Y51_RS10500	COG2160	L-arabinose isomerase activity
D0Y51_RS10505	COG0110	maltose O-acetyltransferase activity
D0Y51_RS10515	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
D0Y51_RS10520	COG1349	DNA-binding transcription factor activity
D0Y51_RS10530	COG3414	Phosphotransferase system galactitol-specific IIB component
D0Y51_RS10535	COG3775	system Galactitol-specific IIC component
D0Y51_RS10550	COG3711	transcriptional antiterminator
D0Y51_RS10570	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D0Y51_RS10585	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
D0Y51_RS10600	COG2211	Major facilitator Superfamily
D0Y51_RS10620	COG1263	PTS System
D0Y51_RS10620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0Y51_RS10620	COG2190	(PTS) system
D0Y51_RS10625	COG2723	6-phospho-beta-galactosidase activity
D0Y51_RS10630	COG2723	6-phospho-beta-galactosidase activity
D0Y51_RS10640	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D0Y51_RS10645	COG1263	PTS System
D0Y51_RS10645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0Y51_RS10650	COG1737	Transcriptional regulator
D0Y51_RS10655	COG2190	(PTS) system
D0Y51_RS10655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0Y51_RS10655	COG1263	PTS System
D0Y51_RS10660	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0Y51_RS10660	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0Y51_RS10660	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0Y51_RS10670	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D0Y51_RS10680	COG3711	transcriptional antiterminator
D0Y51_RS10690	COG2723	6-phospho-beta-galactosidase activity
D0Y51_RS10700	COG2971	BadF BadG BcrA BcrD
D0Y51_RS10705	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D0Y51_RS10715	COG2188	Transcriptional regulator
D0Y51_RS10720	COG2267	carboxylic ester hydrolase activity
D0Y51_RS10730	COG2271	Major facilitator Superfamily
D0Y51_RS10745	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y51_RS10760	COG2271	Major facilitator Superfamily
D0Y51_RS10765	COG0583	DNA-binding transcription factor activity
D0Y51_RS10770	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D0Y51_RS10775	COG0710	3-dehydroquinate dehydratase activity
D0Y51_RS10795	COG0667	Aldo Keto reductase
D0Y51_RS10800	COG1609	Transcriptional regulator
D0Y51_RS10805	COG2017	converts alpha-aldose to the beta-anomer
D0Y51_RS10810	COG2211	Major facilitator Superfamily
D0Y51_RS10810	COG2190	(PTS) system
D0Y51_RS10830	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D0Y51_RS10835	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D0Y51_RS10840	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
D0Y51_RS10845	COG1609	Transcriptional regulator
D0Y51_RS10850	COG2944	sequence-specific DNA binding
D0Y51_RS10855	COG2184	nucleotidyltransferase activity
D0Y51_RS10875	COG0477	Major facilitator Superfamily
D0Y51_RS10885	COG1609	Transcriptional regulator
D0Y51_RS10890	COG1874	Beta-galactosidase
D0Y51_RS10900	COG1114	Component of the transport system for branched-chain amino acids
D0Y51_RS10910	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D0Y51_RS10960	COG0446	pyridine nucleotide-disulphide oxidoreductase
D0Y51_RS10985	COG3590	peptidase
D0Y51_RS10990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D0Y51_RS11010	COG1937	Protein conserved in bacteria
D0Y51_RS11015	COG3118	belongs to the thioredoxin family
D0Y51_RS11020	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D0Y51_RS11025	COG2217	Heavy metal translocating P-type atpase
D0Y51_RS11045	COG2226	methyltransferase
D0Y51_RS11055	COG1309	transcriptional regulator
D0Y51_RS11095	COG0076	glutamate decarboxylase activity
D0Y51_RS11120	COG2207	Transcriptional regulator
D0Y51_RS11155	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
D0Y51_RS11160	COG1968	undecaprenyl-diphosphatase activity
D0Y51_RS11180	COG0656	L-ascorbic acid biosynthetic process
D0Y51_RS11190	COG0737	Belongs to the 5'-nucleotidase family
D0Y51_RS11250	COG0477	Major facilitator Superfamily
D0Y51_RS11275	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
D0Y51_RS11290	COG0697	spore germination
D0Y51_RS11310	COG0071	Belongs to the small heat shock protein (HSP20) family
D0Y51_RS11325	COG1194	a g-specific adenine glycosylase
D0Y51_RS11335	COG3189	MarR family transcriptional regulator
D0Y51_RS11340	COG1393	Belongs to the ArsC family
D0Y51_RS11355	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D0Y51_RS11365	COG1113	amino acid transport
D0Y51_RS11370	COG1757	Na H antiporter
D0Y51_RS11385	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D0Y51_RS11390	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D0Y51_RS11400	COG2315	Protein conserved in bacteria
D0Y51_RS11410	COG2217	Heavy metal translocating P-type atpase
D0Y51_RS11445	COG4989	oxidoreductase activity
D0Y51_RS11450	COG2151	metal-sulfur cluster biosynthetic enzyme
D0Y51_RS11460	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D0Y51_RS11465	COG1882	Formate acetyltransferase
D0Y51_RS11470	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D0Y51_RS11505	COG2814	Major facilitator Superfamily
D0Y51_RS11515	COG0803	Belongs to the bacterial solute-binding protein 9 family
D0Y51_RS11535	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D0Y51_RS11540	COG0302	gtp cyclohydrolase
D0Y51_RS11550	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D0Y51_RS11585	COG0640	Transcriptional regulator
D0Y51_RS11590	COG1272	protein, Hemolysin III
D0Y51_RS11605	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D0Y51_RS11610	COG0628	permease
D0Y51_RS11615	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D0Y51_RS11620	COG3158	transport of potassium into the cell
D0Y51_RS11625	COG0531	amino acid
D0Y51_RS11635	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D0Y51_RS11640	COG2365	Tyrosine phosphatase family
D0Y51_RS11645	COG0516	GMP reductase activity
D0Y51_RS11650	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D0Y51_RS11655	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D0Y51_RS11670	COG1929	Belongs to the glycerate kinase type-1 family
D0Y51_RS11680	COG1562	ergosterol biosynthetic process
D0Y51_RS11685	COG1233	COG1233 Phytoene dehydrogenase and related
D0Y51_RS11690	COG2738	Putative neutral zinc metallopeptidase
D0Y51_RS11700	COG1307	EDD domain protein, DegV family
D0Y51_RS11710	COG1380	Effector of murein hydrolase LrgA
D0Y51_RS11735	COG0735	belongs to the Fur family
D0Y51_RS11765	COG1263	PTS System
D0Y51_RS11765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0Y51_RS11765	COG2190	(PTS) system
D0Y51_RS11780	COG3711	transcriptional antiterminator
D0Y51_RS11780	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0Y51_RS11785	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0Y51_RS11785	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0Y51_RS11785	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0Y51_RS11790	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0Y51_RS11795	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0Y51_RS11795	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0Y51_RS11795	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0Y51_RS11800	COG0383	alpha-mannosidase activity
D0Y51_RS11810	COG0561	phosphatase activity
D0Y51_RS11825	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D0Y51_RS11830	COG4619	ABC transporter
D0Y51_RS11835	COG0390	transport system, permease component
D0Y51_RS11850	COG1609	Transcriptional regulator
D0Y51_RS11855	COG0366	Alpha amylase catalytic
D0Y51_RS11860	COG1263	PTS System
D0Y51_RS11860	COG2190	(PTS) system
D0Y51_RS11860	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0Y51_RS11885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0Y51_RS11890	COG1126	abc transporter atp-binding protein
D0Y51_RS11895	COG0765	amino acid transport
D0Y51_RS11900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0Y51_RS11905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0Y51_RS11910	COG0583	DNA-binding transcription factor activity
D0Y51_RS11925	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D0Y51_RS11930	COG0357	Ribosomal RNA small subunit methyltransferase G
D0Y51_RS11940	COG1192	Involved in chromosome partitioning
D0Y51_RS11945	COG1475	DNA binding
D0Y51_RS11950	COG4481	Protein conserved in bacteria
D0Y51_RS11955	COG0012	GTP binding
D0Y51_RS11965	COG0517	IMP dehydrogenase activity
D0Y51_RS11965	COG0516	GMP reductase activity
D0Y51_RS11970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D0Y51_RS11990	COG1686	Belongs to the peptidase S11 family
D0Y51_RS11995	COG1247	-acetyltransferase
D0Y51_RS12035	COG2815	serine threonine protein kinase
D0Y51_RS12035	COG0515	serine threonine protein kinase
D0Y51_RS12045	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D0Y51_RS12055	COG1940	carbohydrate kinase activity
D0Y51_RS12055	COG1846	Transcriptional regulator
D0Y51_RS12060	COG0628	permease
D0Y51_RS12065	COG0588	phosphoglycerate mutase activity
D0Y51_RS12100	COG0477	Major facilitator Superfamily
D0Y51_RS12120	COG1376	ErfK ybiS ycfS ynhG family protein
D0Y51_RS12140	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D0Y51_RS12165	COG0693	protein deglycase activity
D0Y51_RS12180	COG3711	transcriptional antiterminator
D0Y51_RS12205	COG2190	(PTS) system
D0Y51_RS12205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0Y51_RS12205	COG1263	PTS System
D0Y51_RS12210	COG2723	6-phospho-beta-galactosidase activity
D0Y51_RS12230	COG0783	Belongs to the Dps family
D0Y51_RS12240	COG1053	succinate dehydrogenase
D0Y51_RS12250	COG2816	NAD+ diphosphatase activity
D0Y51_RS12265	COG0481	GTPase activity
D0Y51_RS12305	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y51_RS12310	COG0110	maltose O-acetyltransferase activity
D0Y51_RS12315	COG4221	oxidoreductase activity
D0Y51_RS12325	COG1309	transcriptional regulator
D0Y51_RS12330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0Y51_RS12335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0Y51_RS12340	COG1120	ATPase activity
D0Y51_RS12345	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D0Y51_RS12355	COG0477	Major facilitator Superfamily
D0Y51_RS12360	COG4989	oxidoreductase activity
D0Y51_RS12380	COG0300	oxidoreductase activity
D0Y51_RS12385	COG1733	regulation of RNA biosynthetic process
D0Y51_RS12400	COG1012	belongs to the aldehyde dehydrogenase family
D0Y51_RS12410	COG1309	transcriptional regulator
D0Y51_RS12425	COG3279	Response regulator of the LytR AlgR family
D0Y51_RS12430	COG0367	asparagine synthase
D0Y51_RS12440	COG2814	Major facilitator Superfamily
D0Y51_RS12445	COG1733	regulation of RNA biosynthetic process
D0Y51_RS12450	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0Y51_RS12490	COG1063	alcohol dehydrogenase
D0Y51_RS12550	COG2217	Heavy metal translocating P-type atpase
D0Y51_RS12575	COG0531	amino acid
D0Y51_RS12590	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y51_RS12595	COG1473	amidohydrolase
D0Y51_RS12605	COG1132	(ABC) transporter
D0Y51_RS12610	COG1132	(ABC) transporter
D0Y51_RS12655	COG4221	oxidoreductase activity
D0Y51_RS12670	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D0Y51_RS12695	COG0803	Belongs to the bacterial solute-binding protein 9 family
D0Y51_RS12715	COG0741	lytic transglycosylase activity
D0Y51_RS12720	COG0789	Transcriptional regulator
D0Y51_RS12730	COG2723	6-phospho-beta-galactosidase activity
D0Y51_RS12735	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0Y51_RS12740	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0Y51_RS12775	COG0577	efflux transmembrane transporter activity
D0Y51_RS12775	COG1136	(ABC) transporter
D0Y51_RS12795	COG0640	Transcriptional regulator
D0Y51_RS12815	COG1914	H( )-stimulated, divalent metal cation uptake system
D0Y51_RS12825	COG2246	polysaccharide biosynthetic process
D0Y51_RS12830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D0Y51_RS12830	COG5549	protein import
D0Y51_RS12845	COG0559	Belongs to the binding-protein-dependent transport system permease family
D0Y51_RS12860	COG0410	ABC transporter
D0Y51_RS12865	COG0617	tRNA 3'-terminal CCA addition
D0Y51_RS12865	COG3620	sequence-specific DNA binding
D0Y51_RS12865	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D0Y51_RS12895	COG4120	Belongs to the binding-protein-dependent transport system permease family
D0Y51_RS12905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0Y51_RS12905	COG2190	(PTS) system
D0Y51_RS12905	COG1263	PTS System
D0Y51_RS12910	COG0778	Nitroreductase
D0Y51_RS12920	COG1132	(ABC) transporter
D0Y51_RS12925	COG1940	carbohydrate kinase activity
D0Y51_RS12950	COG0697	spore germination
D0Y51_RS13005	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D0Y51_RS13015	COG0583	DNA-binding transcription factor activity
D0Y51_RS13035	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D0Y51_RS13045	COG0242	peptide deformylase activity
D0Y51_RS13055	COG1328	CTP reductase activity
D0Y51_RS13065	COG2200	EAL domain
D0Y51_RS13120	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D0Y51_RS13130	COG0561	phosphatase activity
D0Y51_RS13135	COG0488	(ABC) transporter
D0Y51_RS13160	COG0640	Transcriptional regulator
D0Y51_RS13170	COG1511	domain protein
D0Y51_RS13170	COG1511	domain protein
D0Y51_RS13185	COG2814	Major facilitator Superfamily
D0Y51_RS13190	COG1132	(ABC) transporter
D0Y51_RS13195	COG1132	(ABC) transporter
D0Y51_RS13200	COG0667	Aldo Keto reductase
D0Y51_RS13210	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D0Y51_RS13225	COG1011	Hydrolase
D0Y51_RS13230	COG0110	maltose O-acetyltransferase activity
D0Y51_RS13235	COG0589	response to stress
D0Y51_RS13255	COG0656	L-ascorbic acid biosynthetic process
D0Y51_RS13260	COG4221	oxidoreductase activity
D0Y51_RS13280	COG0583	DNA-binding transcription factor activity
D0Y51_RS13285	COG0656	L-ascorbic acid biosynthetic process
D0Y51_RS13295	COG4975	Glucose uptake
D0Y51_RS13320	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y51_RS13325	COG1063	alcohol dehydrogenase
D0Y51_RS13335	COG0583	DNA-binding transcription factor activity
D0Y51_RS13360	COG0456	acetyltransferase
D0Y51_RS13385	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D0Y51_RS13405	COG0789	Transcriptional regulator
D0Y51_RS13420	COG4221	oxidoreductase activity
D0Y51_RS13430	COG4152	abc transporter atp-binding protein
D0Y51_RS13440	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D0Y51_RS13455	COG0438	transferase activity, transferring glycosyl groups
D0Y51_RS13465	COG0583	DNA-binding transcription factor activity
D0Y51_RS13470	COG2855	membrane
D0Y51_RS13475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0Y51_RS13485	COG2814	Major facilitator Superfamily
D0Y51_RS13495	COG2814	Major facilitator Superfamily
D0Y51_RS13540	COG1136	(ABC) transporter
D0Y51_RS13545	COG0577	efflux transmembrane transporter activity
D0Y51_RS13560	COG4978	Transcriptional regulator
D0Y51_RS13560	COG0789	Transcriptional regulator
D0Y51_RS13565	COG1811	Na channel or pump
D0Y51_RS13585	COG4990	cell redox homeostasis
D0Y51_RS13600	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D0Y51_RS13605	COG4720	Psort location CytoplasmicMembrane, score
D0Y51_RS13650	COG0531	amino acid
D0Y51_RS13655	COG0710	3-dehydroquinate dehydratase activity
D0Y51_RS13675	COG0716	FMN binding
D0Y51_RS13700	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D0Y51_RS13705	COG0561	phosphatase activity
D0Y51_RS13720	COG1216	Glycosyl transferase, family 2
D0Y51_RS13725	COG2188	Transcriptional regulator
D0Y51_RS13730	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0Y51_RS13740	COG2723	6-phospho-beta-galactosidase activity
D0Y51_RS13745	COG3048	D-serine ammonia-lyase activity
D0Y51_RS13750	COG1131	(ABC) transporter
D0Y51_RS13760	COG1309	transcriptional regulator
D0Y51_RS13765	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D0Y51_RS13770	COG1827	regulation of RNA biosynthetic process
D0Y51_RS13800	COG0494	nUDIX hydrolase
D0Y51_RS13805	COG0110	maltose O-acetyltransferase activity
D0Y51_RS13815	COG0561	phosphatase activity
D0Y51_RS13825	COG0366	Alpha amylase catalytic
D0Y51_RS13845	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D0Y51_RS13865	COG2246	polysaccharide biosynthetic process
D0Y51_RS13875	COG0589	response to stress
D0Y51_RS13885	COG1131	(ABC) transporter
D0Y51_RS13890	COG1725	Transcriptional regulator
D0Y51_RS13905	COG1136	(ABC) transporter
D0Y51_RS13925	COG2365	Tyrosine phosphatase family
D0Y51_RS13930	COG0095	Lipoate-protein ligase
D0Y51_RS13935	COG3976	FMN-binding domain protein
D0Y51_RS13935	COG1053	succinate dehydrogenase
D0Y51_RS13935	COG0431	NADPH-dependent FMN reductase
D0Y51_RS13940	COG3976	FMN-binding domain protein
D0Y51_RS13940	COG0431	NADPH-dependent FMN reductase
D0Y51_RS13940	COG1053	succinate dehydrogenase
D0Y51_RS13950	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D0Y51_RS13955	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D0Y51_RS13960	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D0Y51_RS13965	COG0047	phosphoribosylformylglycinamidine synthase activity
D0Y51_RS13970	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D0Y51_RS13980	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D0Y51_RS13985	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D0Y51_RS13990	COG0138	bifunctional purine biosynthesis protein purh
D0Y51_RS13995	COG0151	Belongs to the GarS family
D0Y51_RS14005	COG1215	transferase activity, transferring glycosyl groups
D0Y51_RS14025	COG2252	PERMEase
D0Y51_RS14030	COG2233	PERMEase
D0Y51_RS14035	COG2508	Transcriptional regulator
D0Y51_RS14040	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D0Y51_RS14045	COG0540	Belongs to the ATCase OTCase family
D0Y51_RS14050	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D0Y51_RS14055	COG0505	Belongs to the CarA family
D0Y51_RS14060	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D0Y51_RS14065	COG0167	dihydroorotate dehydrogenase activity
D0Y51_RS14070	COG0284	orotidine-5'-phosphate decarboxylase activity
D0Y51_RS14075	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D0Y51_RS14085	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
D0Y51_RS14090	COG1074	ATP-dependent DNA helicase activity
D0Y51_RS14100	COG0702	epimerase
D0Y51_RS14105	COG0583	DNA-binding transcription factor activity
D0Y51_RS14120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D0Y51_RS14125	COG0436	Aminotransferase
D0Y51_RS14130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0Y51_RS14140	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D0Y51_RS14150	COG0604	alcohol dehydrogenase
D0Y51_RS14155	COG0789	Transcriptional regulator
D0Y51_RS14160	COG2814	Major facilitator Superfamily
D0Y51_RS14165	COG0025	NhaP-type Na H and K H
D0Y51_RS14170	COG1780	Probably involved in ribonucleotide reductase function
D0Y51_RS14175	COG1253	flavin adenine dinucleotide binding
D0Y51_RS14205	COG1418	mRNA catabolic process
D0Y51_RS14215	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D0Y51_RS14220	COG2188	Transcriptional regulator
D0Y51_RS14230	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
D0Y51_RS14245	COG1396	sequence-specific DNA binding
D0Y51_RS14250	COG4640	response to antibiotic
D0Y51_RS14265	COG0564	pseudouridine synthase activity
D0Y51_RS14270	COG0589	response to stress
D0Y51_RS14275	COG1705	Flagellar rod assembly protein muramidase FlgJ
D0Y51_RS14280	COG0095	Lipoate-protein ligase
D0Y51_RS14310	COG0626	cystathionine gamma-synthase activity
D0Y51_RS14315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D0Y51_RS14320	COG1073	alpha beta
D0Y51_RS14330	COG0028	Belongs to the TPP enzyme family
D0Y51_RS14375	COG1725	Transcriptional regulator
D0Y51_RS14380	COG1131	(ABC) transporter
D0Y51_RS14390	COG1335	isochorismatase
D0Y51_RS14395	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D0Y51_RS14400	COG0025	NhaP-type Na H and K H
D0Y51_RS14405	COG0673	inositol 2-dehydrogenase activity
D0Y51_RS14410	COG0673	inositol 2-dehydrogenase activity
D0Y51_RS14420	COG1609	Transcriptional regulator
D0Y51_RS14430	COG0328	RNA-DNA hybrid ribonuclease activity
D0Y51_RS14440	COG0778	Nitroreductase
D0Y51_RS14445	COG2326	polyphosphate kinase activity
D0Y51_RS14460	COG0492	ferredoxin-NADP+ reductase activity
D0Y51_RS14470	COG0584	glycerophosphoryl diester phosphodiesterase
D0Y51_RS14475	COG1368	sulfuric ester hydrolase activity
D0Y51_RS14495	COG3548	integral membrane protein
D0Y51_RS14510	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D0Y51_RS14520	COG0300	oxidoreductase activity
D0Y51_RS14525	COG0789	Transcriptional regulator
D0Y51_RS14545	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D0Y51_RS14550	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
D0Y51_RS14555	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D0Y51_RS14560	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D0Y51_RS14565	COG0131	Imidazoleglycerol-phosphate dehydratase
D0Y51_RS14570	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D0Y51_RS14575	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D0Y51_RS14580	COG0107	imidazoleglycerol-phosphate synthase activity
D0Y51_RS14585	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D0Y51_RS14590	COG0140	phosphoribosyl-ATP diphosphatase activity
D0Y51_RS14595	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D0Y51_RS14600	COG0110	maltose O-acetyltransferase activity
D0Y51_RS14605	COG0861	Integral membrane protein TerC family
D0Y51_RS14610	COG2084	Dehydrogenase
D0Y51_RS14620	COG0446	pyridine nucleotide-disulphide oxidoreductase
D0Y51_RS14630	COG4120	Belongs to the binding-protein-dependent transport system permease family
D0Y51_RS14645	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
D0Y51_RS14650	COG2873	o-acetylhomoserine
D0Y51_RS14660	COG1307	EDD domain protein, DegV family
D0Y51_RS14665	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D0Y51_RS14670	COG2190	(PTS) system
D0Y51_RS14670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0Y51_RS14670	COG1263	PTS System
D0Y51_RS14700	COG0488	(ABC) transporter
D0Y51_RS14720	COG1522	sequence-specific DNA binding
D0Y51_RS14725	COG0791	NLP P60 protein
D0Y51_RS14745	COG0477	Major facilitator Superfamily
D0Y51_RS14770	COG3830	Belongs to the UPF0237 family
D0Y51_RS14775	COG2848	UPF0210 protein
D0Y51_RS14780	COG0745	RESPONSE REGULATOR receiver
D0Y51_RS14785	COG3850	Histidine kinase
D0Y51_RS14785	COG5002	protein histidine kinase activity
D0Y51_RS14790	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D0Y51_RS14795	COG4975	Glucose uptake
D0Y51_RS14800	COG0166	Belongs to the GPI family
D0Y51_RS14810	COG1136	(ABC) transporter
D0Y51_RS14810	COG0577	efflux transmembrane transporter activity
D0Y51_RS14820	COG1132	(ABC) transporter
D0Y51_RS14865	COG4886	Leucine-rich repeat (LRR) protein
D0Y51_RS14865	COG4932	domain protein
D0Y51_RS14970	COG1396	sequence-specific DNA binding
D0Y51_RS15085	COG5484	DNA packaging
D0Y51_RS15100	COG2868	ribosomal protein
D0Y51_RS15220	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0Y51_RS15245	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D0Y51_RS15255	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
D0Y51_RS15265	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D0Y51_RS15270	COG0562	UDP-galactopyranose mutase
D0Y51_RS15275	COG1216	Glycosyl transferase, family 2
D0Y51_RS15280	COG0438	transferase activity, transferring glycosyl groups
D0Y51_RS15285	COG0438	transferase activity, transferring glycosyl groups
D0Y51_RS15305	COG0438	transferase activity, transferring glycosyl groups
D0Y51_RS15340	COG1088	dTDP-glucose 4,6-dehydratase activity
D0Y51_RS15345	COG0582	viral genome integration into host DNA
D0Y51_RS15355	COG0489	protein tyrosine kinase activity
D0Y51_RS15360	COG4464	protein tyrosine phosphatase activity
D0Y51_RS15375	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
D0Y51_RS15385	COG1088	dTDP-glucose 4,6-dehydratase activity
D0Y51_RS15390	COG1091	dTDP-4-dehydrorhamnose reductase activity
D0Y51_RS15410	COG3475	LICD family
D0Y51_RS15435	COG1216	Glycosyl transferase, family 2
D0Y51_RS15535	COG0562	UDP-galactopyranose mutase
D0Y51_RS15590	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D0Y51_RS15625	COG2137	regulation of response to DNA damage stimulus
D0Y51_RS15630	COG3557	Belongs to the UPF0374 family
D0Y51_RS15660	COG0628	permease
D0Y51_RS15665	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D0Y51_RS15670	COG2610	gluconate transmembrane transporter activity
D0Y51_RS15675	COG1070	Carbohydrate kinase
D0Y51_RS15680	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
D0Y51_RS15685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D0Y51_RS15690	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D0Y51_RS15720	COG4166	transmembrane transport
D0Y51_RS15725	COG0601	transmembrane transport
D0Y51_RS15730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0Y51_RS15735	COG0444	Belongs to the ABC transporter superfamily