locus-tag	class	description
A8P51_RS00040	COG1396	sequence-specific DNA binding
A8P51_RS00055	COG1002	Type II restriction enzyme, methylase subunits
A8P51_RS00070	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A8P51_RS00085	COG1846	Transcriptional regulator
A8P51_RS00105	COG3279	Response regulator of the LytR AlgR family
A8P51_RS00120	COG0561	phosphatase activity
A8P51_RS00125	COG0697	spore germination
A8P51_RS00135	COG0789	Transcriptional regulator
A8P51_RS00155	COG0789	Transcriptional regulator
A8P51_RS00165	COG0596	Alpha beta hydrolase
A8P51_RS00170	COG2378	regulation of single-species biofilm formation
A8P51_RS00190	COG1511	domain protein
A8P51_RS00190	COG1511	domain protein
A8P51_RS00195	COG1970	mechanosensitive ion channel activity
A8P51_RS00200	COG1428	Deoxynucleoside kinase
A8P51_RS00205	COG0584	glycerophosphoryl diester phosphodiesterase
A8P51_RS00215	COG0395	ABC-type sugar transport system, permease component
A8P51_RS00220	COG1175	transmembrane transport
A8P51_RS00225	COG3842	ATPase activity
A8P51_RS00235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A8P51_RS00240	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A8P51_RS00245	COG1187	pseudouridine synthase activity
A8P51_RS00250	COG2244	polysaccharide biosynthetic process
A8P51_RS00255	COG0495	leucyl-tRNA aminoacylation
A8P51_RS00265	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A8P51_RS00280	COG0438	transferase activity, transferring glycosyl groups
A8P51_RS00295	COG0477	Major facilitator Superfamily
A8P51_RS00300	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A8P51_RS00310	COG0438	transferase activity, transferring glycosyl groups
A8P51_RS00315	COG2040	homocysteine
A8P51_RS00320	COG0833	amino acid
A8P51_RS00325	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A8P51_RS00340	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A8P51_RS00360	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A8P51_RS00450	COG1368	sulfuric ester hydrolase activity
A8P51_RS00455	COG4703	Protein of unknown function (DUF1797)
A8P51_RS00460	COG0436	Aminotransferase
A8P51_RS00465	COG1686	Belongs to the peptidase S11 family
A8P51_RS00475	COG0438	transferase activity, transferring glycosyl groups
A8P51_RS00480	COG0438	transferase activity, transferring glycosyl groups
A8P51_RS00500	COG0542	response to heat
A8P51_RS00505	COG0582	viral genome integration into host DNA
A8P51_RS00515	COG4608	Belongs to the ABC transporter superfamily
A8P51_RS00520	COG0444	Belongs to the ABC transporter superfamily
A8P51_RS00525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8P51_RS00530	COG0601	transmembrane transport
A8P51_RS00535	COG4166	transmembrane transport
A8P51_RS00565	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A8P51_RS00570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A8P51_RS00575	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A8P51_RS00580	COG1070	Carbohydrate kinase
A8P51_RS00585	COG2610	gluconate transmembrane transporter activity
A8P51_RS00590	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A8P51_RS00595	COG0628	permease
A8P51_RS00605	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A8P51_RS00625	COG3557	Belongs to the UPF0374 family
A8P51_RS00630	COG2137	regulation of response to DNA damage stimulus
A8P51_RS00665	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A8P51_RS00685	COG1609	Transcriptional regulator
A8P51_RS00685	COG2207	Transcriptional regulator
A8P51_RS00720	COG0562	UDP-galactopyranose mutase
A8P51_RS00755	COG5039	Polysaccharide pyruvyl transferase
A8P51_RS00760	COG1215	transferase activity, transferring glycosyl groups
A8P51_RS00780	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A8P51_RS00790	COG4464	protein tyrosine phosphatase activity
A8P51_RS00795	COG0489	protein tyrosine kinase activity
A8P51_RS00805	COG0582	viral genome integration into host DNA
A8P51_RS00810	COG1091	dTDP-4-dehydrorhamnose reductase activity
A8P51_RS00815	COG1088	dTDP-glucose 4,6-dehydratase activity
A8P51_RS00825	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A8P51_RS00870	COG0438	transferase activity, transferring glycosyl groups
A8P51_RS00885	COG2801	Transposase and inactivated derivatives
A8P51_RS00900	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A8P51_RS00910	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A8P51_RS00920	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A8P51_RS00945	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A8P51_RS00960	COG0513	Belongs to the DEAD box helicase family
A8P51_RS00965	COG0673	inositol 2-dehydrogenase activity
A8P51_RS00970	COG1278	Cold shock
A8P51_RS00985	COG1737	Transcriptional regulator
A8P51_RS00995	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A8P51_RS01010	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A8P51_RS01015	COG1597	lipid kinase activity
A8P51_RS01020	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A8P51_RS01025	COG0154	amidase activity
A8P51_RS01030	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A8P51_RS01035	COG4851	CamS sex pheromone cAM373 precursor
A8P51_RS01040	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A8P51_RS01050	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A8P51_RS01055	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
A8P51_RS01060	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A8P51_RS01065	COG1705	Flagellar rod assembly protein muramidase FlgJ
A8P51_RS01080	COG0142	geranyltranstransferase activity
A8P51_RS01095	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A8P51_RS01100	COG4988	ABC transporter
A8P51_RS01105	COG1294	oxidase, subunit
A8P51_RS01110	COG1271	oxidase subunit
A8P51_RS01120	COG4684	Psort location CytoplasmicMembrane, score
A8P51_RS01125	COG0531	amino acid
A8P51_RS01135	COG0281	malic enzyme
A8P51_RS01140	COG0583	DNA-binding transcription factor activity
A8P51_RS01145	COG0583	DNA-binding transcription factor activity
A8P51_RS01155	COG1053	succinate dehydrogenase
A8P51_RS01160	COG0114	fumarate hydratase activity
A8P51_RS01185	COG2826	transposase and inactivated derivatives, IS30 family
A8P51_RS01200	COG3052	prosthetic group binding
A8P51_RS01220	COG0471	metal ion transport
A8P51_RS01225	COG0039	L-malate dehydrogenase activity
A8P51_RS01240	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A8P51_RS01245	COG1121	(ABC) transporter
A8P51_RS01250	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
A8P51_RS01255	COG4977	sequence-specific DNA binding
A8P51_RS01255	COG1917	Cupin 2, conserved barrel domain protein
A8P51_RS01265	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A8P51_RS01270	COG2151	metal-sulfur cluster biosynthetic enzyme
A8P51_RS01275	COG0471	metal ion transport
A8P51_RS01280	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A8P51_RS01285	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A8P51_RS01290	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A8P51_RS01295	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A8P51_RS01315	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A8P51_RS01320	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A8P51_RS01325	COG0101	tRNA pseudouridine synthase activity
A8P51_RS01335	COG1122	ATPase activity
A8P51_RS01340	COG1122	ATPase activity
A8P51_RS01350	COG4939	FMN-binding domain protein
A8P51_RS01385	COG0203	ribosomal protein L17
A8P51_RS01390	COG0202	RNA polymerase activity
A8P51_RS01395	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A8P51_RS01400	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A8P51_RS01405	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A8P51_RS01410	COG0563	adenylate kinase activity
A8P51_RS01420	COG0200	Binds to the 23S rRNA
A8P51_RS01425	COG1841	ribosomal large subunit assembly
A8P51_RS01430	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A8P51_RS01435	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A8P51_RS01440	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A8P51_RS01445	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A8P51_RS01450	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A8P51_RS01455	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A8P51_RS01460	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A8P51_RS01465	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A8P51_RS01470	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A8P51_RS01475	COG0255	Belongs to the universal ribosomal protein uL29 family
A8P51_RS01480	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A8P51_RS01485	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A8P51_RS01490	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A8P51_RS01495	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A8P51_RS01500	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A8P51_RS01505	COG0089	rRNA binding
A8P51_RS01510	COG0088	Forms part of the polypeptide exit tunnel
A8P51_RS01515	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A8P51_RS01520	COG0051	transcription antitermination factor activity, RNA binding
A8P51_RS01525	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A8P51_RS01530	COG0049	tRNA binding
A8P51_RS01535	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A8P51_RS01540	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A8P51_RS01545	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A8P51_RS01550	COG0085	RNA polymerase activity
A8P51_RS01560	COG0542	response to heat
A8P51_RS01565	COG4463	regulation of RNA biosynthetic process
A8P51_RS01605	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A8P51_RS01610	COG1428	Deoxynucleoside kinase
A8P51_RS01620	COG0833	amino acid
A8P51_RS01625	COG0028	Belongs to the TPP enzyme family
A8P51_RS01630	COG1959	2 iron, 2 sulfur cluster binding
A8P51_RS01650	COG1316	TRANSCRIPTIONal
A8P51_RS01660	COG2966	Psort location CytoplasmicMembrane, score
A8P51_RS01665	COG1278	Cold shock
A8P51_RS01685	COG2814	Major facilitator Superfamily
A8P51_RS01715	COG0367	asparagine synthase
A8P51_RS01720	COG0527	aspartate kinase activity
A8P51_RS01725	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A8P51_RS01775	COG0640	Transcriptional regulator
A8P51_RS01780	COG0564	pseudouridine synthase activity
A8P51_RS01785	COG0514	ATP-dependent DNA helicase (RecQ)
A8P51_RS01805	COG4690	dipeptidase activity
A8P51_RS01810	COG2502	aspartate--ammonia ligase
A8P51_RS01815	COG0017	Asparaginyl-tRNA synthetase
A8P51_RS01820	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A8P51_RS01830	COG1053	succinate dehydrogenase
A8P51_RS01835	COG0583	DNA-binding transcription factor activity
A8P51_RS01850	COG0572	uridine kinase
A8P51_RS01870	COG0308	aminopeptidase N
A8P51_RS01900	COG1302	Protein conserved in bacteria
A8P51_RS01915	COG2261	transglycosylase associated protein
A8P51_RS01920	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A8P51_RS01920	COG2755	lipolytic protein G-D-S-L family
A8P51_RS01935	COG2814	Major facilitator Superfamily
A8P51_RS01940	COG1733	regulation of RNA biosynthetic process
A8P51_RS01945	COG1266	CAAX protease self-immunity
A8P51_RS01955	COG1396	sequence-specific DNA binding
A8P51_RS01965	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A8P51_RS01965	COG0519	Catalyzes the synthesis of GMP from XMP
A8P51_RS01970	COG1072	(Pantothenic acid kinase))
A8P51_RS01975	COG2070	2-Nitropropane dioxygenase
A8P51_RS01980	COG3973	AAA domain
A8P51_RS01985	COG0586	Pfam SNARE associated Golgi protein
A8P51_RS01990	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A8P51_RS01990	COG0456	acetyltransferase
A8P51_RS01995	COG0475	glutathione-regulated potassium exporter activity
A8P51_RS01995	COG0569	domain protein
A8P51_RS02000	COG0588	phosphoglycerate mutase activity
A8P51_RS02015	COG2076	Multidrug Resistance protein
A8P51_RS02025	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A8P51_RS02055	COG1846	Transcriptional regulator
A8P51_RS02060	COG0531	amino acid
A8P51_RS02065	COG3394	polysaccharide catabolic process
A8P51_RS02070	COG1263	PTS System
A8P51_RS02070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8P51_RS02080	COG1263	PTS System
A8P51_RS02080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8P51_RS02080	COG2190	(PTS) system
A8P51_RS02085	COG0765	amino acid transport
A8P51_RS02090	COG0765	amino acid transport
A8P51_RS02095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8P51_RS02110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A8P51_RS02115	COG0436	Aminotransferase
A8P51_RS02120	COG0546	phosphoglycolate phosphatase activity
A8P51_RS02135	COG0735	belongs to the Fur family
A8P51_RS02140	COG0194	GDP metabolic process
A8P51_RS02160	COG0531	amino acid
A8P51_RS02175	COG2936	dipeptidyl-peptidase activity
A8P51_RS02180	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A8P51_RS02180	COG2755	lipolytic protein G-D-S-L family
A8P51_RS02190	COG2267	carboxylic ester hydrolase activity
A8P51_RS02195	COG0028	Belongs to the TPP enzyme family
A8P51_RS02200	COG0196	riboflavin kinase activity
A8P51_RS02205	COG0028	Belongs to the TPP enzyme family
A8P51_RS02210	COG2252	PERMEase
A8P51_RS02220	COG3475	LICD family
A8P51_RS02230	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A8P51_RS02235	COG0248	Ppx GppA phosphatase
A8P51_RS02235	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A8P51_RS02240	COG0477	Major facilitator Superfamily
A8P51_RS02255	COG1393	Belongs to the ArsC family
A8P51_RS02270	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A8P51_RS02285	COG0778	Nitroreductase
A8P51_RS02300	COG2017	converts alpha-aldose to the beta-anomer
A8P51_RS02310	COG0561	phosphatase activity
A8P51_RS02320	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A8P51_RS02325	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A8P51_RS02350	COG0025	NhaP-type Na H and K H
A8P51_RS02355	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A8P51_RS02365	COG0708	Exodeoxyribonuclease III
A8P51_RS02380	COG0802	atpase or kinase
A8P51_RS02385	COG0280	phosphate acetyltransferase
A8P51_RS02390	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A8P51_RS02395	COG0561	phosphatase activity
A8P51_RS02405	COG1126	abc transporter atp-binding protein
A8P51_RS02410	COG0765	amino acid transport
A8P51_RS02420	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A8P51_RS02425	COG0557	exoribonuclease II activity
A8P51_RS02435	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A8P51_RS02440	COG0038	chloride channel
A8P51_RS02450	COG0148	phosphopyruvate hydratase activity
A8P51_RS02455	COG0149	triose-phosphate isomerase activity
A8P51_RS02460	COG0126	phosphoglycerate kinase activity
A8P51_RS02470	COG2390	Transcriptional regulator
A8P51_RS02475	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A8P51_RS02485	COG0740	serine-type endopeptidase activity
A8P51_RS02490	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A8P51_RS02500	COG1481	regulation of sporulation
A8P51_RS02510	COG1660	Displays ATPase and GTPase activities
A8P51_RS02520	COG0165	Argininosuccinate lyase
A8P51_RS02525	COG0137	argininosuccinate synthase activity
A8P51_RS02530	COG1854	S-ribosylhomocysteine lyase activity
A8P51_RS02535	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A8P51_RS02540	COG0556	nucleotide-excision repair
A8P51_RS02550	COG2814	Major facilitator Superfamily
A8P51_RS02560	COG0446	pyridine nucleotide-disulphide oxidoreductase
A8P51_RS02570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A8P51_RS02580	COG2323	membrane
A8P51_RS02585	COG0492	ferredoxin-NADP+ reductase activity
A8P51_RS02590	COG0446	pyridine nucleotide-disulphide oxidoreductase
A8P51_RS02600	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A8P51_RS02605	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A8P51_RS02610	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A8P51_RS02615	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A8P51_RS02620	COG1950	PFAM Membrane protein of
A8P51_RS02625	COG1983	PspC domain protein
A8P51_RS02630	COG0704	Plays a role in the regulation of phosphate uptake
A8P51_RS02635	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A8P51_RS02640	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A8P51_RS02645	COG0581	inorganic phosphate transmembrane transporter activity
A8P51_RS02650	COG0573	inorganic phosphate transmembrane transporter activity
A8P51_RS02655	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A8P51_RS02660	COG5002	protein histidine kinase activity
A8P51_RS02665	COG0745	RESPONSE REGULATOR receiver
A8P51_RS02680	COG0653	protein targeting
A8P51_RS02690	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A8P51_RS02695	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
A8P51_RS02700	COG1739	Uncharacterized protein family UPF0029
A8P51_RS02705	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A8P51_RS02710	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A8P51_RS02715	COG0531	amino acid
A8P51_RS02720	COG0459	protein refolding
A8P51_RS02725	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A8P51_RS02735	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
A8P51_RS02740	COG0488	(ABC) transporter
A8P51_RS02745	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A8P51_RS02750	COG0456	acetyltransferase
A8P51_RS02755	COG0456	acetyltransferase
A8P51_RS02760	COG1214	PFAM Peptidase M22, glycoprotease
A8P51_RS02770	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A8P51_RS02780	COG3639	organic phosphonate transmembrane transporter activity
A8P51_RS02785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A8P51_RS02790	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A8P51_RS02795	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A8P51_RS02810	COG4467	Involved in initiation control of chromosome replication
A8P51_RS02815	COG0470	DNA polymerase III
A8P51_RS02820	COG3870	Protein conserved in bacteria
A8P51_RS02825	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A8P51_RS02845	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A8P51_RS02860	COG2813	Specifically methylates the guanine in position
A8P51_RS02865	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A8P51_RS02870	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A8P51_RS02880	COG1611	Belongs to the LOG family
A8P51_RS02900	COG0222	ribosome binding
A8P51_RS02905	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A8P51_RS02910	COG0081	regulation of translation
A8P51_RS02915	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A8P51_RS02925	COG0250	Participates in transcription elongation, termination and antitermination
A8P51_RS02935	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A8P51_RS02950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A8P51_RS02955	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
A8P51_RS02960	COG0215	cysteine-tRNA ligase activity
A8P51_RS02965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A8P51_RS02970	COG4956	integral membrane protein (PIN domain superfamily)
A8P51_RS02980	COG0756	dUTP diphosphatase activity
A8P51_RS02990	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A8P51_RS03005	COG0588	phosphoglycerate mutase activity
A8P51_RS03010	COG0697	spore germination
A8P51_RS03020	COG1316	TRANSCRIPTIONal
A8P51_RS03025	COG0825	malonyl-CoA metabolic process
A8P51_RS03035	COG0439	Biotin carboxylase
A8P51_RS03045	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A8P51_RS03050	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8P51_RS03050	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8P51_RS03055	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8P51_RS03055	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8P51_RS03060	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A8P51_RS03060	COG3933	PFAM sigma-54 factor interaction domain-containing protein
A8P51_RS03070	COG3716	PTS system mannose fructose sorbose family IID component
A8P51_RS03075	COG3715	PTS system
A8P51_RS03095	COG0083	homoserine kinase activity
A8P51_RS03100	COG0460	homoserine dehydrogenase
A8P51_RS03105	COG3091	SprT-like family
A8P51_RS03110	COG2183	response to ionizing radiation
A8P51_RS03125	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A8P51_RS03130	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A8P51_RS03140	COG2188	Transcriptional regulator
A8P51_RS03150	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A8P51_RS03200	COG3104	oligopeptide transport
A8P51_RS03240	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A8P51_RS03245	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A8P51_RS03250	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A8P51_RS03265	COG0037	tRNA processing
A8P51_RS03270	COG1098	S1 RNA binding domain
A8P51_RS03280	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A8P51_RS03285	COG2244	polysaccharide biosynthetic process
A8P51_RS03290	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A8P51_RS03295	COG0193	aminoacyl-tRNA hydrolase activity
A8P51_RS03300	COG0039	L-malate dehydrogenase activity
A8P51_RS03320	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A8P51_RS03325	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A8P51_RS03330	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A8P51_RS03335	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A8P51_RS03340	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A8P51_RS03345	COG0505	Belongs to the CarA family
A8P51_RS03350	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A8P51_RS03355	COG3158	transport of potassium into the cell
A8P51_RS03360	COG2337	Toxic component of a toxin-antitoxin (TA) module
A8P51_RS03365	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A8P51_RS03370	COG0736	holo-[acyl-carrier-protein] synthase activity
A8P51_RS03380	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A8P51_RS03390	COG0501	Belongs to the peptidase M48B family
A8P51_RS03395	COG1704	LemA family
A8P51_RS03400	COG3764	Sortase (surface protein transpeptidase)
A8P51_RS03410	COG0254	rRNA binding
A8P51_RS03415	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A8P51_RS03420	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A8P51_RS03435	COG1760	l-serine dehydratase
A8P51_RS03440	COG1760	l-serine dehydratase
A8P51_RS03445	COG0814	amino acid
A8P51_RS03450	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A8P51_RS03455	COG0504	CTP synthase activity
A8P51_RS03460	COG3343	RNA polymerase activity
A8P51_RS03470	COG0095	Lipoate-protein ligase
A8P51_RS03475	COG1078	dGTPase activity
A8P51_RS03495	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A8P51_RS03505	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A8P51_RS03510	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A8P51_RS03535	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A8P51_RS03535	COG1321	iron dependent repressor
A8P51_RS03540	COG1121	(ABC) transporter
A8P51_RS03545	COG1073	alpha beta
A8P51_RS03550	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A8P51_RS03555	COG4466	Protein conserved in bacteria
A8P51_RS03560	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A8P51_RS03565	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A8P51_RS03570	COG0084	hydrolase, TatD family'
A8P51_RS03585	COG2814	Major facilitator Superfamily
A8P51_RS03595	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A8P51_RS03595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A8P51_RS03605	COG1801	Protein of unknown function DUF72
A8P51_RS03610	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A8P51_RS03625	COG0248	Ppx GppA phosphatase
A8P51_RS03640	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A8P51_RS03650	COG1940	carbohydrate kinase activity
A8P51_RS03655	COG2723	6-phospho-beta-galactosidase activity
A8P51_RS03660	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A8P51_RS03675	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A8P51_RS03680	COG2188	Transcriptional regulator
A8P51_RS03685	COG0180	Tryptophanyl-tRNA synthetase
A8P51_RS03690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A8P51_RS03695	COG3973	AAA domain
A8P51_RS03730	COG2274	protein secretion by the type I secretion system
A8P51_RS03755	COG3290	protein histidine kinase activity
A8P51_RS03775	COG1114	Component of the transport system for branched-chain amino acids
A8P51_RS03780	COG0561	phosphatase activity
A8P51_RS03790	COG0561	phosphatase activity
A8P51_RS03800	COG0110	maltose O-acetyltransferase activity
A8P51_RS03820	COG3328	transposase activity
A8P51_RS03875	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A8P51_RS03885	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A8P51_RS03895	COG1125	glycine betaine transport
A8P51_RS03915	COG0300	oxidoreductase activity
A8P51_RS03945	COG1881	PFAM PEBP family protein
A8P51_RS03950	COG3759	membrane
A8P51_RS03960	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A8P51_RS03980	COG0004	ammonium transporteR
A8P51_RS03985	COG2814	Major facilitator Superfamily
A8P51_RS04000	COG1134	teichoic acid transport
A8P51_RS04005	COG1682	transport, permease protein
A8P51_RS04015	COG0436	Aminotransferase
A8P51_RS04030	COG1268	BioY protein
A8P51_RS04065	COG1012	belongs to the aldehyde dehydrogenase family
A8P51_RS04065	COG1454	alcohol dehydrogenase
A8P51_RS04075	COG1131	(ABC) transporter
A8P51_RS04080	COG1725	Transcriptional regulator
A8P51_RS04110	COG3842	ATPase activity
A8P51_RS04135	COG1252	NADH dehydrogenase
A8P51_RS04140	COG1846	Transcriptional regulator
A8P51_RS04150	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A8P51_RS04180	COG1388	LysM domain
A8P51_RS04180	COG3942	CHAP domain
A8P51_RS04185	COG0741	lytic transglycosylase activity
A8P51_RS04200	COG1136	(ABC) transporter
A8P51_RS04205	COG0577	efflux transmembrane transporter activity
A8P51_RS04215	COG2818	Glycosylase
A8P51_RS04220	COG2409	Drug exporters of the RND superfamily
A8P51_RS04220	COG1033	growth of symbiont in host cell
A8P51_RS04230	COG2357	RelA SpoT domain protein
A8P51_RS04240	COG0277	FAD linked oxidase domain protein
A8P51_RS04245	COG1316	TRANSCRIPTIONal
A8P51_RS04260	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A8P51_RS04265	COG1737	Transcriptional regulator
A8P51_RS04275	COG0745	RESPONSE REGULATOR receiver
A8P51_RS04280	COG5002	protein histidine kinase activity
A8P51_RS04290	COG2814	Major facilitator Superfamily
A8P51_RS04310	COG1914	H( )-stimulated, divalent metal cation uptake system
A8P51_RS04315	COG1309	transcriptional regulator
A8P51_RS04320	COG1959	2 iron, 2 sulfur cluster binding
A8P51_RS04330	COG0163	prenyltransferase activity
A8P51_RS04335	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A8P51_RS04340	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A8P51_RS04345	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A8P51_RS04355	COG1263	PTS System
A8P51_RS04355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8P51_RS04355	COG2190	(PTS) system
A8P51_RS04360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8P51_RS04360	COG2190	(PTS) system
A8P51_RS04360	COG1263	PTS System
A8P51_RS04365	COG0366	Alpha amylase catalytic
A8P51_RS04370	COG2188	Transcriptional regulator
A8P51_RS04395	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A8P51_RS04400	COG0626	cystathionine gamma-synthase activity
A8P51_RS04405	COG1045	serine acetyltransferase
A8P51_RS04410	COG0431	NADPH-dependent FMN reductase
A8P51_RS04440	COG3118	belongs to the thioredoxin family
A8P51_RS04450	COG0246	Mannitol dehydrogenase
A8P51_RS04455	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8P51_RS04465	COG2213	PTS system mannitol-specific
A8P51_RS04480	COG1053	succinate dehydrogenase
A8P51_RS04480	COG3976	FMN-binding domain protein
A8P51_RS04490	COG0363	glucosamine-6-phosphate deaminase activity
A8P51_RS04505	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A8P51_RS04515	COG0386	Belongs to the glutathione peroxidase family
A8P51_RS04525	COG4172	Belongs to the ABC transporter superfamily
A8P51_RS04535	COG0488	(ABC) transporter
A8P51_RS04540	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A8P51_RS04545	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A8P51_RS04575	COG0667	Aldo Keto reductase
A8P51_RS04580	COG0406	alpha-ribazole phosphatase activity
A8P51_RS04585	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A8P51_RS04590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A8P51_RS04600	COG4166	transmembrane transport
A8P51_RS04605	COG4166	transmembrane transport
A8P51_RS04630	COG1757	Na H antiporter
A8P51_RS04685	COG3842	ATPase activity
A8P51_RS04700	COG3833	ABC-type maltose transport systems, permease component
A8P51_RS04705	COG1175	transmembrane transport
A8P51_RS04710	COG2182	Extracellular solute-binding protein
A8P51_RS04715	COG0366	Alpha amylase catalytic
A8P51_RS04720	COG1609	Transcriptional regulator
A8P51_RS04725	COG1609	Transcriptional regulator
A8P51_RS04730	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A8P51_RS04735	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
A8P51_RS04740	COG1461	Dihydroxyacetone kinase
A8P51_RS04745	COG2376	Dihydroxyacetone kinase
A8P51_RS04750	COG2376	Dihydroxyacetone kinase
A8P51_RS04755	COG1309	transcriptional regulator
A8P51_RS04760	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
A8P51_RS04765	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A8P51_RS04780	COG1131	(ABC) transporter
A8P51_RS04785	COG1028	Short-chain dehydrogenase reductase Sdr
A8P51_RS04810	COG2188	Transcriptional regulator
A8P51_RS04820	COG4720	Psort location CytoplasmicMembrane, score
A8P51_RS04825	COG1122	ATPase activity
A8P51_RS04830	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A8P51_RS04860	COG0667	Aldo Keto reductase
A8P51_RS04865	COG0656	L-ascorbic acid biosynthetic process
A8P51_RS04870	COG2807	transmembrane transport
A8P51_RS04905	COG1983	PspC domain protein
A8P51_RS04915	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A8P51_RS04920	COG2267	carboxylic ester hydrolase activity
A8P51_RS04930	COG1113	amino acid transport
A8P51_RS04945	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A8P51_RS04955	COG0352	thiamine-phosphate diphosphorylase activity
A8P51_RS04960	COG0351	phosphomethylpyrimidine kinase
A8P51_RS04965	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A8P51_RS04975	COG1606	tRNA processing
A8P51_RS04980	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A8P51_RS04985	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
A8P51_RS04990	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
A8P51_RS04995	COG1691	(AIR) carboxylase
A8P51_RS05000	COG3875	lactate racemase activity
A8P51_RS05005	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A8P51_RS05010	COG0310	cobalt ion transport
A8P51_RS05015	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A8P51_RS05020	COG1122	ATPase activity
A8P51_RS05045	COG4166	transmembrane transport
A8P51_RS05055	COG3022	response to hydroperoxide
A8P51_RS05060	COG2267	carboxylic ester hydrolase activity
A8P51_RS05075	COG0604	alcohol dehydrogenase
A8P51_RS05115	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A8P51_RS05135	COG2368	4-hydroxyphenylacetate
A8P51_RS05140	COG2365	Tyrosine phosphatase family
A8P51_RS05155	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A8P51_RS05160	COG2508	Transcriptional regulator
A8P51_RS05170	COG0778	Nitroreductase
A8P51_RS05180	COG1028	Short-chain dehydrogenase reductase Sdr
A8P51_RS05185	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A8P51_RS05200	COG0471	metal ion transport
A8P51_RS05205	COG3976	FMN-binding domain protein
A8P51_RS05205	COG1053	succinate dehydrogenase
A8P51_RS05205	COG0431	NADPH-dependent FMN reductase
A8P51_RS05225	COG1573	uracil-dna glycosylase
A8P51_RS05230	COG3586	endonuclease activity
A8P51_RS05235	COG1012	belongs to the aldehyde dehydrogenase family
A8P51_RS05305	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A8P51_RS05310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A8P51_RS05315	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A8P51_RS05320	COG4853	Protein conserved in bacteria
A8P51_RS05330	COG5002	protein histidine kinase activity
A8P51_RS05335	COG0745	RESPONSE REGULATOR receiver
A8P51_RS05350	COG1278	Cold shock
A8P51_RS05360	COG1554	hydrolase, family 65, central catalytic
A8P51_RS05365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A8P51_RS05375	COG3103	Sh3 type 3 domain protein
A8P51_RS05375	COG0366	Alpha amylase catalytic
A8P51_RS05380	COG0058	SHG alpha-glucan phosphorylase activity
A8P51_RS05385	COG0297	glycogen (starch) synthase activity
A8P51_RS05390	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A8P51_RS05395	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A8P51_RS05400	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A8P51_RS05405	COG4166	transmembrane transport
A8P51_RS05410	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A8P51_RS05415	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A8P51_RS05420	COG2814	Major facilitator Superfamily
A8P51_RS05425	COG0305	Participates in initiation and elongation during chromosome replication
A8P51_RS05430	COG0359	binds to the 23S rRNA
A8P51_RS05440	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A8P51_RS05445	COG0629	single-stranded DNA binding
A8P51_RS05450	COG0360	Binds together with S18 to 16S ribosomal RNA
A8P51_RS05460	COG0187	DNA topoisomerase II activity
A8P51_RS05465	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A8P51_RS05470	COG2501	S4 domain
A8P51_RS05475	COG0592	DNA-directed DNA polymerase activity
A8P51_RS05480	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A8P51_RS05485	COG0594	ribonuclease P activity
A8P51_RS05490	COG0706	membrane insertase activity
A8P51_RS05495	COG1847	R3H domain protein
A8P51_RS05500	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A8P51_RS05505	COG0445	tRNA wobble uridine modification
A8P51_RS05545	COG1307	EDD domain protein, DegV family
A8P51_RS05565	COG3479	Phenolic acid decarboxylase
A8P51_RS05570	COG1695	Transcriptional regulator
A8P51_RS05580	COG1012	belongs to the aldehyde dehydrogenase family
A8P51_RS05580	COG1454	alcohol dehydrogenase
A8P51_RS05585	COG1609	Transcriptional regulator
A8P51_RS05595	COG1869	D-ribose catabolic process
A8P51_RS05600	COG4975	Glucose uptake
A8P51_RS05620	COG3730	PTS system glucitol sorbitol-specific
A8P51_RS05625	COG3732	PTS system glucitol sorbitol-specific
A8P51_RS05640	COG2188	Transcriptional regulator
A8P51_RS05645	COG1132	(ABC) transporter
A8P51_RS05650	COG1132	(ABC) transporter
A8P51_RS05655	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A8P51_RS05655	COG2207	Transcriptional regulator
A8P51_RS05670	COG0395	ABC-type sugar transport system, permease component
A8P51_RS05675	COG1653	transport
A8P51_RS05680	COG0366	Alpha amylase catalytic
A8P51_RS05690	COG2972	Histidine kinase
A8P51_RS05695	COG4753	response regulator
A8P51_RS05695	COG2207	Transcriptional regulator
A8P51_RS05705	COG3842	ATPase activity
A8P51_RS05715	COG2188	Transcriptional regulator
A8P51_RS05725	COG0383	alpha-mannosidase activity
A8P51_RS05730	COG1940	carbohydrate kinase activity
A8P51_RS05735	COG2723	6-phospho-beta-galactosidase activity
A8P51_RS05745	COG0366	Alpha amylase catalytic
A8P51_RS05755	COG1609	Transcriptional regulator
A8P51_RS05765	COG3711	transcriptional antiterminator
A8P51_RS05765	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8P51_RS05775	COG3730	PTS system glucitol sorbitol-specific
A8P51_RS05780	COG3732	PTS system glucitol sorbitol-specific
A8P51_RS05795	COG1957	nucleoside hydrolase
A8P51_RS05800	COG0604	alcohol dehydrogenase
A8P51_RS05805	COG4702	Belongs to the UPF0303 family
A8P51_RS05810	COG0673	inositol 2-dehydrogenase activity
A8P51_RS05815	COG2814	Major facilitator Superfamily
A8P51_RS05820	COG0673	inositol 2-dehydrogenase activity
A8P51_RS05825	COG1082	Xylose isomerase domain protein TIM barrel
A8P51_RS05830	COG0673	inositol 2-dehydrogenase activity
A8P51_RS05835	COG0673	inositol 2-dehydrogenase activity
A8P51_RS05840	COG2814	Major facilitator Superfamily
A8P51_RS05855	COG3775	system Galactitol-specific IIC component
A8P51_RS05870	COG1349	DNA-binding transcription factor activity
A8P51_RS05875	COG2207	Transcriptional regulator
A8P51_RS05880	COG2814	Major facilitator Superfamily
A8P51_RS05885	COG1070	Carbohydrate kinase
A8P51_RS05890	COG3254	rhamnose metabolic process
A8P51_RS05895	COG4806	L-rhamnose isomerase
A8P51_RS05900	COG0235	Class ii aldolase
A8P51_RS05915	COG0028	Belongs to the TPP enzyme family
A8P51_RS05920	COG1959	2 iron, 2 sulfur cluster binding
A8P51_RS05925	COG0028	Belongs to the TPP enzyme family
A8P51_RS05930	COG1304	FMN binding
A8P51_RS05945	COG4512	PFAM Accessory gene regulator B
A8P51_RS05965	COG1393	Belongs to the ArsC family
A8P51_RS05975	COG2261	transglycosylase associated protein
A8P51_RS05995	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
A8P51_RS06000	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A8P51_RS06020	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A8P51_RS06040	COG1737	Transcriptional regulator
A8P51_RS06045	COG1609	Transcriptional regulator
A8P51_RS06065	COG2160	L-arabinose isomerase activity
A8P51_RS06070	COG0110	maltose O-acetyltransferase activity
A8P51_RS06080	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
A8P51_RS06085	COG1349	DNA-binding transcription factor activity
A8P51_RS06095	COG3414	Phosphotransferase system galactitol-specific IIB component
A8P51_RS06100	COG3775	system Galactitol-specific IIC component
A8P51_RS06115	COG3711	transcriptional antiterminator
A8P51_RS06135	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A8P51_RS06150	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
A8P51_RS06165	COG2211	Major facilitator Superfamily
A8P51_RS06185	COG2190	(PTS) system
A8P51_RS06185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8P51_RS06185	COG1263	PTS System
A8P51_RS06190	COG2723	6-phospho-beta-galactosidase activity
A8P51_RS06195	COG2723	6-phospho-beta-galactosidase activity
A8P51_RS06205	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A8P51_RS06210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8P51_RS06210	COG1263	PTS System
A8P51_RS06215	COG1737	Transcriptional regulator
A8P51_RS06220	COG2190	(PTS) system
A8P51_RS06220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8P51_RS06220	COG1263	PTS System
A8P51_RS06225	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A8P51_RS06225	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A8P51_RS06225	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8P51_RS06230	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A8P51_RS06230	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A8P51_RS06235	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A8P51_RS06245	COG3711	transcriptional antiterminator
A8P51_RS06255	COG2723	6-phospho-beta-galactosidase activity
A8P51_RS06265	COG2971	BadF BadG BcrA BcrD
A8P51_RS06270	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A8P51_RS06275	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A8P51_RS06280	COG2188	Transcriptional regulator
A8P51_RS06285	COG2267	carboxylic ester hydrolase activity
A8P51_RS06295	COG0738	Major facilitator superfamily
A8P51_RS06300	COG0583	DNA-binding transcription factor activity
A8P51_RS06305	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A8P51_RS06310	COG0738	Major facilitator superfamily
A8P51_RS06315	COG0710	3-dehydroquinate dehydratase activity
A8P51_RS06345	COG1609	Transcriptional regulator
A8P51_RS06350	COG2017	converts alpha-aldose to the beta-anomer
A8P51_RS06355	COG2190	(PTS) system
A8P51_RS06355	COG2211	Major facilitator Superfamily
A8P51_RS06375	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A8P51_RS06380	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A8P51_RS06385	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
A8P51_RS06390	COG1609	Transcriptional regulator
A8P51_RS06395	COG2944	sequence-specific DNA binding
A8P51_RS06400	COG2184	nucleotidyltransferase activity
A8P51_RS06420	COG0477	Major facilitator Superfamily
A8P51_RS06430	COG1609	Transcriptional regulator
A8P51_RS06435	COG1874	Beta-galactosidase
A8P51_RS06445	COG1114	Component of the transport system for branched-chain amino acids
A8P51_RS06455	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A8P51_RS06505	COG0446	pyridine nucleotide-disulphide oxidoreductase
A8P51_RS06520	COG3590	peptidase
A8P51_RS06525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A8P51_RS06545	COG1937	Protein conserved in bacteria
A8P51_RS06550	COG3118	belongs to the thioredoxin family
A8P51_RS06555	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A8P51_RS06560	COG2217	Heavy metal translocating P-type atpase
A8P51_RS06575	COG2226	methyltransferase
A8P51_RS06585	COG1309	transcriptional regulator
A8P51_RS06630	COG0076	glutamate decarboxylase activity
A8P51_RS06655	COG2207	Transcriptional regulator
A8P51_RS06690	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A8P51_RS06695	COG1968	undecaprenyl-diphosphatase activity
A8P51_RS06715	COG0656	L-ascorbic acid biosynthetic process
A8P51_RS06725	COG0737	Belongs to the 5'-nucleotidase family
A8P51_RS06775	COG0477	Major facilitator Superfamily
A8P51_RS06800	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
A8P51_RS06815	COG0697	spore germination
A8P51_RS06835	COG0071	Belongs to the small heat shock protein (HSP20) family
A8P51_RS06850	COG1194	a g-specific adenine glycosylase
A8P51_RS06860	COG3189	MarR family transcriptional regulator
A8P51_RS06865	COG1393	Belongs to the ArsC family
A8P51_RS06880	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A8P51_RS06890	COG1113	amino acid transport
A8P51_RS06895	COG1757	Na H antiporter
A8P51_RS06905	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A8P51_RS06910	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A8P51_RS06920	COG2315	Protein conserved in bacteria
A8P51_RS06930	COG2217	Heavy metal translocating P-type atpase
A8P51_RS06960	COG4989	oxidoreductase activity
A8P51_RS06965	COG2151	metal-sulfur cluster biosynthetic enzyme
A8P51_RS06970	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A8P51_RS06975	COG1882	Formate acetyltransferase
A8P51_RS06980	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A8P51_RS07010	COG2814	Major facilitator Superfamily
A8P51_RS07015	COG0803	Belongs to the bacterial solute-binding protein 9 family
A8P51_RS07030	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A8P51_RS07035	COG0302	gtp cyclohydrolase
A8P51_RS07045	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A8P51_RS07080	COG0640	Transcriptional regulator
A8P51_RS07085	COG1272	protein, Hemolysin III
A8P51_RS07100	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A8P51_RS07105	COG0628	permease
A8P51_RS07110	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A8P51_RS07115	COG3158	transport of potassium into the cell
A8P51_RS07120	COG0531	amino acid
A8P51_RS07135	COG1511	domain protein
A8P51_RS07145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A8P51_RS07150	COG2365	Tyrosine phosphatase family
A8P51_RS07155	COG0516	GMP reductase activity
A8P51_RS07160	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A8P51_RS07165	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A8P51_RS07180	COG1929	Belongs to the glycerate kinase type-1 family
A8P51_RS07190	COG1562	ergosterol biosynthetic process
A8P51_RS07195	COG1233	COG1233 Phytoene dehydrogenase and related
A8P51_RS07200	COG2738	Putative neutral zinc metallopeptidase
A8P51_RS07205	COG1307	EDD domain protein, DegV family
A8P51_RS07215	COG1380	Effector of murein hydrolase LrgA
A8P51_RS07240	COG0735	belongs to the Fur family
A8P51_RS07275	COG1263	PTS System
A8P51_RS07275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8P51_RS07275	COG2190	(PTS) system
A8P51_RS07290	COG0561	phosphatase activity
A8P51_RS07305	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A8P51_RS07310	COG4619	ABC transporter
A8P51_RS07315	COG0390	transport system, permease component
A8P51_RS07325	COG1609	Transcriptional regulator
A8P51_RS07330	COG0366	Alpha amylase catalytic
A8P51_RS07355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8P51_RS07360	COG1126	abc transporter atp-binding protein
A8P51_RS07365	COG0765	amino acid transport
A8P51_RS07370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8P51_RS07375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8P51_RS07380	COG0583	DNA-binding transcription factor activity
A8P51_RS07395	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A8P51_RS07400	COG0357	Ribosomal RNA small subunit methyltransferase G
A8P51_RS07410	COG1192	Involved in chromosome partitioning
A8P51_RS07415	COG1475	DNA binding
A8P51_RS07420	COG4481	Protein conserved in bacteria
A8P51_RS07425	COG0012	GTP binding
A8P51_RS07435	COG0517	IMP dehydrogenase activity
A8P51_RS07435	COG0516	GMP reductase activity
A8P51_RS07440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A8P51_RS07460	COG1686	Belongs to the peptidase S11 family
A8P51_RS07465	COG1247	-acetyltransferase
A8P51_RS07505	COG0515	serine threonine protein kinase
A8P51_RS07505	COG2815	serine threonine protein kinase
A8P51_RS07515	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A8P51_RS07525	COG1846	Transcriptional regulator
A8P51_RS07525	COG1940	carbohydrate kinase activity
A8P51_RS07530	COG0628	permease
A8P51_RS07535	COG0588	phosphoglycerate mutase activity
A8P51_RS07560	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A8P51_RS07570	COG0577	efflux transmembrane transporter activity
A8P51_RS07570	COG1136	(ABC) transporter
A8P51_RS07585	COG0693	protein deglycase activity
A8P51_RS07605	COG0789	Transcriptional regulator
A8P51_RS07625	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A8P51_RS07630	COG2723	6-phospho-beta-galactosidase activity
A8P51_RS07640	COG0783	Belongs to the Dps family
A8P51_RS07650	COG1053	succinate dehydrogenase
A8P51_RS07660	COG2816	NAD+ diphosphatase activity
A8P51_RS07670	COG0481	GTPase activity
A8P51_RS07705	COG1028	Short-chain dehydrogenase reductase Sdr
A8P51_RS07710	COG0110	maltose O-acetyltransferase activity
A8P51_RS07715	COG4221	oxidoreductase activity
A8P51_RS07730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8P51_RS07735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8P51_RS07740	COG1120	ATPase activity
A8P51_RS07745	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A8P51_RS07755	COG0477	Major facilitator Superfamily
A8P51_RS07760	COG4989	oxidoreductase activity
A8P51_RS07780	COG0300	oxidoreductase activity
A8P51_RS07785	COG1733	regulation of RNA biosynthetic process
A8P51_RS07800	COG1012	belongs to the aldehyde dehydrogenase family
A8P51_RS07810	COG1309	transcriptional regulator
A8P51_RS07825	COG3279	Response regulator of the LytR AlgR family
A8P51_RS07830	COG0367	asparagine synthase
A8P51_RS07840	COG2814	Major facilitator Superfamily
A8P51_RS07845	COG1733	regulation of RNA biosynthetic process
A8P51_RS07860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A8P51_RS07900	COG1063	alcohol dehydrogenase
A8P51_RS07955	COG2217	Heavy metal translocating P-type atpase
A8P51_RS07975	COG0531	amino acid
A8P51_RS07990	COG1028	Short-chain dehydrogenase reductase Sdr
A8P51_RS07995	COG1473	amidohydrolase
A8P51_RS08000	COG1132	(ABC) transporter
A8P51_RS08005	COG1132	(ABC) transporter
A8P51_RS08020	COG1028	Short-chain dehydrogenase reductase Sdr
A8P51_RS08050	COG4221	oxidoreductase activity
A8P51_RS08070	COG1073	alpha beta
A8P51_RS08075	COG1028	Short-chain dehydrogenase reductase Sdr
A8P51_RS08095	COG0667	Aldo Keto reductase
A8P51_RS08110	COG0789	Transcriptional regulator
A8P51_RS08125	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A8P51_RS08150	COG0803	Belongs to the bacterial solute-binding protein 9 family
A8P51_RS08170	COG0741	lytic transglycosylase activity
A8P51_RS08175	COG0789	Transcriptional regulator
A8P51_RS08185	COG2723	6-phospho-beta-galactosidase activity
A8P51_RS08190	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A8P51_RS08195	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A8P51_RS08230	COG0577	efflux transmembrane transporter activity
A8P51_RS08230	COG1136	(ABC) transporter
A8P51_RS08240	COG0640	Transcriptional regulator
A8P51_RS08260	COG1914	H( )-stimulated, divalent metal cation uptake system
A8P51_RS08270	COG2246	polysaccharide biosynthetic process
A8P51_RS08275	COG5549	protein import
A8P51_RS08275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A8P51_RS08290	COG0559	Belongs to the binding-protein-dependent transport system permease family
A8P51_RS08305	COG0410	ABC transporter
A8P51_RS08310	COG3620	sequence-specific DNA binding
A8P51_RS08310	COG0617	tRNA 3'-terminal CCA addition
A8P51_RS08310	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A8P51_RS08340	COG4120	Belongs to the binding-protein-dependent transport system permease family
A8P51_RS08345	COG1116	anion transmembrane transporter activity
A8P51_RS08350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8P51_RS08350	COG2190	(PTS) system
A8P51_RS08350	COG1263	PTS System
A8P51_RS08355	COG0778	Nitroreductase
A8P51_RS08365	COG1132	(ABC) transporter
A8P51_RS08370	COG1940	carbohydrate kinase activity
A8P51_RS08395	COG0697	spore germination
A8P51_RS08440	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A8P51_RS08450	COG0583	DNA-binding transcription factor activity
A8P51_RS08465	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A8P51_RS08475	COG0242	peptide deformylase activity
A8P51_RS08485	COG1328	CTP reductase activity
A8P51_RS08495	COG2200	EAL domain
A8P51_RS08535	COG2270	Major facilitator Superfamily
A8P51_RS08550	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A8P51_RS08560	COG0561	phosphatase activity
A8P51_RS08565	COG0488	(ABC) transporter
A8P51_RS08595	COG0640	Transcriptional regulator
A8P51_RS08605	COG1511	domain protein
A8P51_RS08605	COG1511	domain protein
A8P51_RS08620	COG2814	Major facilitator Superfamily
A8P51_RS08625	COG1132	(ABC) transporter
A8P51_RS08630	COG1132	(ABC) transporter
A8P51_RS08635	COG0667	Aldo Keto reductase
A8P51_RS08660	COG1011	Hydrolase
A8P51_RS08665	COG0110	maltose O-acetyltransferase activity
A8P51_RS08670	COG0589	response to stress
A8P51_RS08680	COG1028	Short-chain dehydrogenase reductase Sdr
A8P51_RS08685	COG1063	alcohol dehydrogenase
A8P51_RS08695	COG0583	DNA-binding transcription factor activity
A8P51_RS08720	COG0456	acetyltransferase
A8P51_RS08745	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A8P51_RS08765	COG0789	Transcriptional regulator
A8P51_RS08780	COG4221	oxidoreductase activity
A8P51_RS08790	COG4152	abc transporter atp-binding protein
A8P51_RS08795	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A8P51_RS08810	COG0438	transferase activity, transferring glycosyl groups
A8P51_RS08820	COG0583	DNA-binding transcription factor activity
A8P51_RS08825	COG2855	membrane
A8P51_RS08830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A8P51_RS08850	COG2814	Major facilitator Superfamily
A8P51_RS08890	COG1136	(ABC) transporter
A8P51_RS08895	COG0577	efflux transmembrane transporter activity
A8P51_RS08910	COG0789	Transcriptional regulator
A8P51_RS08910	COG4978	Transcriptional regulator
A8P51_RS08915	COG1811	Na channel or pump
A8P51_RS08925	COG4990	cell redox homeostasis
A8P51_RS08940	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A8P51_RS08945	COG4720	Psort location CytoplasmicMembrane, score
A8P51_RS08990	COG0531	amino acid
A8P51_RS08995	COG0710	3-dehydroquinate dehydratase activity
A8P51_RS09015	COG0716	FMN binding
A8P51_RS09040	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A8P51_RS09045	COG0561	phosphatase activity
A8P51_RS09060	COG1216	Glycosyl transferase, family 2
A8P51_RS09065	COG2188	Transcriptional regulator
A8P51_RS09070	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A8P51_RS09075	COG1447	Phosphotransferase system cellobiose-specific component IIA
A8P51_RS09080	COG2723	6-phospho-beta-galactosidase activity
A8P51_RS09085	COG2723	6-phospho-beta-galactosidase activity
A8P51_RS09090	COG3048	D-serine ammonia-lyase activity
A8P51_RS09095	COG1131	(ABC) transporter
A8P51_RS09105	COG1309	transcriptional regulator
A8P51_RS09110	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A8P51_RS09115	COG1827	regulation of RNA biosynthetic process
A8P51_RS09180	COG0494	nUDIX hydrolase
A8P51_RS09185	COG0110	maltose O-acetyltransferase activity
A8P51_RS09195	COG0561	phosphatase activity
A8P51_RS09205	COG0366	Alpha amylase catalytic
A8P51_RS09225	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A8P51_RS09245	COG2246	polysaccharide biosynthetic process
A8P51_RS09255	COG0589	response to stress
A8P51_RS09265	COG1131	(ABC) transporter
A8P51_RS09270	COG1725	Transcriptional regulator
A8P51_RS09285	COG1136	(ABC) transporter
A8P51_RS09305	COG2365	Tyrosine phosphatase family
A8P51_RS09310	COG0095	Lipoate-protein ligase
A8P51_RS09315	COG0431	NADPH-dependent FMN reductase
A8P51_RS09315	COG1053	succinate dehydrogenase
A8P51_RS09315	COG3976	FMN-binding domain protein
A8P51_RS09320	COG0431	NADPH-dependent FMN reductase
A8P51_RS09320	COG1053	succinate dehydrogenase
A8P51_RS09320	COG3976	FMN-binding domain protein
A8P51_RS09330	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A8P51_RS09335	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A8P51_RS09340	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A8P51_RS09345	COG0047	phosphoribosylformylglycinamidine synthase activity
A8P51_RS09350	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A8P51_RS09360	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A8P51_RS09365	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A8P51_RS09370	COG0138	bifunctional purine biosynthesis protein purh
A8P51_RS09375	COG0151	Belongs to the GarS family
A8P51_RS09385	COG1215	transferase activity, transferring glycosyl groups
A8P51_RS09405	COG2252	PERMEase
A8P51_RS09410	COG2233	PERMEase
A8P51_RS09415	COG2508	Transcriptional regulator
A8P51_RS09420	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A8P51_RS09425	COG0540	Belongs to the ATCase OTCase family
A8P51_RS09430	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A8P51_RS09435	COG0505	Belongs to the CarA family
A8P51_RS09440	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A8P51_RS09445	COG0167	dihydroorotate dehydrogenase activity
A8P51_RS09450	COG0284	orotidine-5'-phosphate decarboxylase activity
A8P51_RS09455	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A8P51_RS09465	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
A8P51_RS09470	COG1074	ATP-dependent DNA helicase activity
A8P51_RS09480	COG0702	epimerase
A8P51_RS09485	COG0583	DNA-binding transcription factor activity
A8P51_RS09495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A8P51_RS09500	COG0436	Aminotransferase
A8P51_RS09505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8P51_RS09510	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A8P51_RS09520	COG0604	alcohol dehydrogenase
A8P51_RS09525	COG0789	Transcriptional regulator
A8P51_RS09530	COG2814	Major facilitator Superfamily
A8P51_RS09535	COG0025	NhaP-type Na H and K H
A8P51_RS09540	COG1780	Probably involved in ribonucleotide reductase function
A8P51_RS09545	COG1253	flavin adenine dinucleotide binding
A8P51_RS09575	COG1418	mRNA catabolic process
A8P51_RS09585	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A8P51_RS09590	COG2188	Transcriptional regulator
A8P51_RS09600	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
A8P51_RS09615	COG1396	sequence-specific DNA binding
A8P51_RS09620	COG4640	response to antibiotic
A8P51_RS09635	COG0564	pseudouridine synthase activity
A8P51_RS09640	COG0589	response to stress
A8P51_RS09645	COG1705	Flagellar rod assembly protein muramidase FlgJ
A8P51_RS09650	COG0095	Lipoate-protein ligase
A8P51_RS09680	COG0626	cystathionine gamma-synthase activity
A8P51_RS09685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8P51_RS09690	COG1073	alpha beta
A8P51_RS09700	COG0028	Belongs to the TPP enzyme family
A8P51_RS09740	COG1725	Transcriptional regulator
A8P51_RS09745	COG1131	(ABC) transporter
A8P51_RS09755	COG1335	isochorismatase
A8P51_RS09760	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A8P51_RS09765	COG0025	NhaP-type Na H and K H
A8P51_RS09770	COG0673	inositol 2-dehydrogenase activity
A8P51_RS09775	COG0673	inositol 2-dehydrogenase activity
A8P51_RS09785	COG1609	Transcriptional regulator
A8P51_RS09795	COG0328	RNA-DNA hybrid ribonuclease activity
A8P51_RS09805	COG0778	Nitroreductase
A8P51_RS09810	COG2326	polyphosphate kinase activity
A8P51_RS09815	COG4932	domain protein
A8P51_RS09825	COG0492	ferredoxin-NADP+ reductase activity
A8P51_RS09830	COG0584	glycerophosphoryl diester phosphodiesterase
A8P51_RS09835	COG1368	sulfuric ester hydrolase activity
A8P51_RS09855	COG3548	integral membrane protein
A8P51_RS09870	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A8P51_RS09880	COG0300	oxidoreductase activity
A8P51_RS09885	COG0789	Transcriptional regulator
A8P51_RS09905	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A8P51_RS09910	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A8P51_RS09915	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A8P51_RS09920	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A8P51_RS09925	COG0131	Imidazoleglycerol-phosphate dehydratase
A8P51_RS09930	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A8P51_RS09935	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A8P51_RS09940	COG0107	imidazoleglycerol-phosphate synthase activity
A8P51_RS09945	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A8P51_RS09950	COG0140	phosphoribosyl-ATP diphosphatase activity
A8P51_RS09955	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A8P51_RS09960	COG0110	maltose O-acetyltransferase activity
A8P51_RS09965	COG0861	Integral membrane protein TerC family
A8P51_RS09970	COG2084	Dehydrogenase
A8P51_RS09975	COG0446	pyridine nucleotide-disulphide oxidoreductase
A8P51_RS09985	COG4120	Belongs to the binding-protein-dependent transport system permease family
A8P51_RS09995	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
A8P51_RS10000	COG2873	o-acetylhomoserine
A8P51_RS10010	COG1307	EDD domain protein, DegV family
A8P51_RS10015	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A8P51_RS10020	COG1263	PTS System
A8P51_RS10020	COG2190	(PTS) system
A8P51_RS10020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8P51_RS10040	COG0488	(ABC) transporter
A8P51_RS10065	COG1522	sequence-specific DNA binding
A8P51_RS10070	COG0791	NLP P60 protein
A8P51_RS10085	COG0477	Major facilitator Superfamily
A8P51_RS10105	COG0697	spore germination
A8P51_RS10110	COG3830	Belongs to the UPF0237 family
A8P51_RS10115	COG2848	UPF0210 protein
A8P51_RS10120	COG0745	RESPONSE REGULATOR receiver
A8P51_RS10125	COG3850	Histidine kinase
A8P51_RS10125	COG5002	protein histidine kinase activity
A8P51_RS10130	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A8P51_RS10135	COG4975	Glucose uptake
A8P51_RS10140	COG0166	Belongs to the GPI family
A8P51_RS10150	COG0577	efflux transmembrane transporter activity
A8P51_RS10150	COG1136	(ABC) transporter
A8P51_RS10160	COG1132	(ABC) transporter
A8P51_RS10165	COG4932	domain protein
A8P51_RS10165	COG4886	Leucine-rich repeat (LRR) protein
A8P51_RS10485	COG0726	polysaccharide deacetylase
A8P51_RS10500	COG1132	(ABC) transporter
A8P51_RS10520	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A8P51_RS10530	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A8P51_RS10535	COG1482	cell wall glycoprotein biosynthetic process
A8P51_RS10540	COG3442	glutamine amidotransferase
A8P51_RS10545	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A8P51_RS10550	COG1435	thymidine kinase activity
A8P51_RS10555	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A8P51_RS10560	COG2890	protein-(glutamine-N5) methyltransferase activity
A8P51_RS10565	COG0009	L-threonylcarbamoyladenylate synthase
A8P51_RS10570	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A8P51_RS10575	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A8P51_RS10585	COG2233	PERMEase
A8P51_RS10590	COG0356	it plays a direct role in the translocation of protons across the membrane
A8P51_RS10595	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A8P51_RS10600	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A8P51_RS10605	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A8P51_RS10610	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A8P51_RS10615	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A8P51_RS10620	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A8P51_RS10625	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A8P51_RS10630	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A8P51_RS10640	COG1077	Cell shape determining protein MreB Mrl
A8P51_RS10645	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A8P51_RS10655	COG0772	Belongs to the SEDS family
A8P51_RS10660	COG0509	glycine decarboxylation via glycine cleavage system
A8P51_RS10665	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A8P51_RS10670	COG2011	ABC-type metal ion transport system permease component
A8P51_RS10675	COG1464	Belongs to the NlpA lipoprotein family
A8P51_RS10695	COG1181	Belongs to the D-alanine--D-alanine ligase family
A8P51_RS10715	COG0589	response to stress
A8P51_RS10730	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A8P51_RS10735	COG2918	glutathione biosynthetic process
A8P51_RS10735	COG0189	ligase activity
A8P51_RS10740	COG1609	Transcriptional regulator
A8P51_RS10745	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8P51_RS10750	COG3715	PTS system
A8P51_RS10755	COG3716	PTS system mannose fructose sorbose family IID component
A8P51_RS10765	COG0366	Alpha amylase catalytic
A8P51_RS10770	COG0640	Transcriptional regulator
A8P51_RS10785	COG4493	Belongs to the UPF0637 family
A8P51_RS10790	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A8P51_RS10795	COG1956	GAF domain-containing protein
A8P51_RS10800	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
A8P51_RS10810	COG1104	cysteine desulfurase activity
A8P51_RS10815	COG0301	tRNA thio-modification
A8P51_RS10820	COG1181	Belongs to the D-alanine--D-alanine ligase family
A8P51_RS10820	COG2918	glutathione biosynthetic process
A8P51_RS10830	COG0525	valine-tRNA ligase activity
A8P51_RS10835	COG0285	dihydrofolate synthase activity
A8P51_RS10840	COG2003	Belongs to the UPF0758 family
A8P51_RS10845	COG1077	Cell shape determining protein MreB Mrl
A8P51_RS10850	COG1792	Involved in formation and maintenance of cell shape
A8P51_RS10860	COG0850	regulation of cytokinetic process
A8P51_RS10865	COG2894	cell division
A8P51_RS10870	COG0765	amino acid transport
A8P51_RS10875	COG1126	abc transporter atp-binding protein
A8P51_RS10880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8P51_RS10885	COG0527	aspartate kinase activity
A8P51_RS10890	COG0612	Peptidase, M16
A8P51_RS10895	COG0612	Peptidase, M16
A8P51_RS10900	COG1426	Protein conserved in bacteria
A8P51_RS10905	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A8P51_RS10910	COG1058	Belongs to the CinA family
A8P51_RS10910	COG1546	Belongs to the CinA family
A8P51_RS10915	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A8P51_RS10920	COG1418	mRNA catabolic process
A8P51_RS10925	COG1692	metallophosphoesterase
A8P51_RS10930	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A8P51_RS10935	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A8P51_RS10955	COG0632	four-way junction helicase activity
A8P51_RS10960	COG2255	four-way junction helicase activity
A8P51_RS10965	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A8P51_RS10970	COG0343	queuine tRNA-ribosyltransferase activity
A8P51_RS10975	COG1862	Preprotein translocase
A8P51_RS10980	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A8P51_RS10985	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A8P51_RS10990	COG0513	Belongs to the DEAD box helicase family
A8P51_RS10995	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A8P51_RS11000	COG4472	Bacterial protein of unknown function (DUF965)
A8P51_RS11005	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A8P51_RS11010	COG3906	Belongs to the UPF0473 family
A8P51_RS11020	COG1193	negative regulation of DNA recombination
A8P51_RS11025	COG3118	belongs to the thioredoxin family
A8P51_RS11030	COG1719	4-vinyl reductase, 4VR
A8P51_RS11035	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A8P51_RS11040	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A8P51_RS11050	COG0517	IMP dehydrogenase activity
A8P51_RS11055	COG2171	N-acyltransferase activity
A8P51_RS11060	COG1473	amidohydrolase
A8P51_RS11065	COG0668	transmembrane transport
A8P51_RS11080	COG0789	Transcriptional regulator
A8P51_RS11085	COG0006	proline dipeptidase activity
A8P51_RS11090	COG1609	Transcriptional regulator
A8P51_RS11105	COG0217	transcriptional regulatory protein
A8P51_RS11115	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A8P51_RS11145	COG0827	DNA restriction-modification system
A8P51_RS11150	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A8P51_RS11155	COG1113	amino acid transport
A8P51_RS11165	COG0737	Belongs to the 5'-nucleotidase family
A8P51_RS11170	COG4470	Protein conserved in bacteria
A8P51_RS11175	COG0647	UMP catabolic process
A8P51_RS11185	COG0586	Pfam SNARE associated Golgi protein
A8P51_RS11195	COG1098	S1 RNA binding domain
A8P51_RS11335	COG1234	tRNA 3'-trailer cleavage
A8P51_RS11340	COG1393	Belongs to the ArsC family
A8P51_RS11345	COG4862	establishment of competence for transformation
A8P51_RS11355	COG1164	Oligoendopeptidase f
A8P51_RS11365	COG2357	RelA SpoT domain protein
A8P51_RS11370	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A8P51_RS11375	COG0564	pseudouridine synthase activity
A8P51_RS11380	COG3142	Participates in the control of copper homeostasis
A8P51_RS11385	COG2706	6-phosphogluconolactonase activity
A8P51_RS11395	COG0628	permease
A8P51_RS11400	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A8P51_RS11410	COG1114	Component of the transport system for branched-chain amino acids
A8P51_RS11420	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A8P51_RS11425	COG1674	ftsk spoiiie
A8P51_RS11440	COG2001	Belongs to the MraZ family
A8P51_RS11445	COG0275	rRNA processing
A8P51_RS11455	COG0768	penicillin binding
A8P51_RS11460	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A8P51_RS11465	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A8P51_RS11470	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A8P51_RS11475	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A8P51_RS11490	COG1799	cell septum assembly
A8P51_RS11495	COG0762	integral membrane protein
A8P51_RS11505	COG3599	regulation of cell shape
A8P51_RS11510	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A8P51_RS11515	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A8P51_RS11520	COG0494	nUDIX hydrolase
A8P51_RS11530	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A8P51_RS11535	COG1104	cysteine desulfurase activity
A8P51_RS11545	COG0482	sulfurtransferase activity
A8P51_RS11550	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A8P51_RS11555	COG0569	domain protein
A8P51_RS11585	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A8P51_RS11590	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A8P51_RS11595	COG1388	LysM domain
A8P51_RS11595	COG3584	3D domain protein
A8P51_RS11605	COG1597	lipid kinase activity
A8P51_RS11610	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A8P51_RS11615	COG5503	Protein of unknown function (DUF1447)
A8P51_RS11625	COG0242	peptide deformylase activity
A8P51_RS11650	COG0039	L-malate dehydrogenase activity
A8P51_RS11655	COG4476	Belongs to the UPF0223 family
A8P51_RS11660	COG0483	inositol monophosphate 1-phosphatase activity
A8P51_RS11665	COG1217	gtp-binding protein TYPA
A8P51_RS11690	COG0772	Belongs to the SEDS family
A8P51_RS11695	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A8P51_RS11700	COG4471	UPF0298 protein
A8P51_RS11705	COG0742	ribosomal rna small subunit methyltransferase
A8P51_RS11710	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A8P51_RS11715	COG3480	Lon protease (S16) C-terminal proteolytic domain
A8P51_RS11720	COG1596	polysaccharide export
A8P51_RS11720	COG1555	photosystem II stabilization
A8P51_RS11725	COG2131	deaminase
A8P51_RS11730	COG0658	competence protein
A8P51_RS11730	COG2333	competence protein COMEC
A8P51_RS11735	COG1466	dna polymerase III delta subunit
A8P51_RS11740	COG0268	Binds directly to 16S ribosomal RNA
A8P51_RS11745	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A8P51_RS11770	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A8P51_RS11775	COG0544	peptidyl-prolyl cis-trans isomerase activity
A8P51_RS11780	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A8P51_RS11785	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A8P51_RS11800	COG0765	amino acid transport
A8P51_RS11805	COG1126	abc transporter atp-binding protein
A8P51_RS11810	COG0322	excinuclease ABC activity
A8P51_RS11820	COG0489	protein tyrosine kinase activity
A8P51_RS11835	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A8P51_RS11840	COG0297	glycogen (starch) synthase activity
A8P51_RS11865	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A8P51_RS11870	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8P51_RS11870	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A8P51_RS11870	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A8P51_RS11875	COG1105	Belongs to the carbohydrate kinase PfkB family
A8P51_RS11880	COG1349	DNA-binding transcription factor activity
A8P51_RS11885	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A8P51_RS11895	COG1234	tRNA 3'-trailer cleavage
A8P51_RS11900	COG0300	oxidoreductase activity
A8P51_RS11905	COG5416	Lipopolysaccharide assembly protein A domain
A8P51_RS11910	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A8P51_RS11910	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A8P51_RS11915	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A8P51_RS11930	COG0393	Putative heavy-metal-binding
A8P51_RS12170	COG3953	SLT domain
A8P51_RS12170	COG5280	Phage tail tape measure protein TP901
A8P51_RS12190	COG3328	transposase activity
A8P51_RS12230	COG0772	Belongs to the SEDS family
A8P51_RS12240	COG1116	anion transmembrane transporter activity
A8P51_RS12245	COG1316	TRANSCRIPTIONal
A8P51_RS12255	COG0463	Glycosyl transferase, family 2
A8P51_RS12270	COG3425	synthase
A8P51_RS12280	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A8P51_RS12285	COG4224	UPF0291 protein
A8P51_RS12290	COG3763	UPF0154 protein
A8P51_RS12295	COG0204	Acyl-transferase
A8P51_RS12300	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A8P51_RS12305	COG2827	Endonuclease containing a URI domain
A8P51_RS12310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A8P51_RS12320	COG0052	Belongs to the universal ribosomal protein uS2 family
A8P51_RS12325	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A8P51_RS12330	COG0528	UMP kinase activity
A8P51_RS12335	COG0233	cytoplasmic translational termination
A8P51_RS12340	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A8P51_RS12345	COG4589	Belongs to the CDS family
A8P51_RS12350	COG0750	zinc metalloprotease
A8P51_RS12355	COG0442	prolyl-tRNA aminoacylation
A8P51_RS12360	COG2176	DNA-directed DNA polymerase activity
A8P51_RS12365	COG0779	Required for maturation of 30S ribosomal subunits
A8P51_RS12370	COG0195	Participates in both transcription termination and antitermination
A8P51_RS12375	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A8P51_RS12385	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A8P51_RS12390	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A8P51_RS12400	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A8P51_RS12410	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A8P51_RS12415	COG0287	Prephenate dehydrogenase
A8P51_RS12420	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A8P51_RS12425	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A8P51_RS12430	COG0196	riboflavin kinase activity
A8P51_RS12435	COG3527	Alpha-acetolactate decarboxylase
A8P51_RS12440	COG1420	regulation of RNA biosynthetic process
A8P51_RS12445	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A8P51_RS12450	COG0443	Heat shock 70 kDa protein
A8P51_RS12455	COG0484	heat shock protein binding
A8P51_RS12460	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A8P51_RS12470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8P51_RS12475	COG1696	Membrane protein involved in D-alanine export
A8P51_RS12480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8P51_RS12485	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A8P51_RS12490	COG0481	GTPase activity
A8P51_RS12505	COG2094	Belongs to the DNA glycosylase MPG family
A8P51_RS12510	COG2264	protein methyltransferase activity
A8P51_RS12515	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A8P51_RS12525	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A8P51_RS12530	COG1490	D-aminoacyl-tRNA deacylase activity
A8P51_RS12535	COG0546	phosphoglycolate phosphatase activity
A8P51_RS12540	COG3001	Fructosamine kinase
A8P51_RS12545	COG3103	Sh3 type 3 domain protein
A8P51_RS12545	COG0860	N-Acetylmuramoyl-L-alanine amidase
A8P51_RS12545	COG4991	sh3 domain protein
A8P51_RS12550	COG0124	histidyl-tRNA synthetase
A8P51_RS12555	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A8P51_RS12565	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A8P51_RS12575	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A8P51_RS12585	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A8P51_RS12590	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A8P51_RS12595	COG1610	YqeY-like protein
A8P51_RS12600	COG1702	phosphate starvation-inducible protein PhoH
A8P51_RS12605	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A8P51_RS12610	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A8P51_RS12615	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A8P51_RS12620	COG1381	Involved in DNA repair and RecF pathway recombination
A8P51_RS12625	COG0752	glycyl-tRNA synthetase alpha subunit
A8P51_RS12630	COG0751	glycine-tRNA ligase activity
A8P51_RS12635	COG0358	DNA primase activity
A8P51_RS12640	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A8P51_RS12645	COG1725	Transcriptional regulator
A8P51_RS12650	COG1131	(ABC) transporter
A8P51_RS12670	COG1131	(ABC) transporter
A8P51_RS12690	COG0519	Catalyzes the synthesis of GMP from XMP
A8P51_RS12695	COG1131	(ABC) transporter
A8P51_RS12705	COG4585	Histidine kinase
A8P51_RS12710	COG2197	response regulator
A8P51_RS12715	COG0446	pyridine nucleotide-disulphide oxidoreductase
A8P51_RS12725	COG0604	alcohol dehydrogenase
A8P51_RS12730	COG0583	DNA-binding transcription factor activity
A8P51_RS12760	COG0546	phosphoglycolate phosphatase activity
A8P51_RS12780	COG1393	Belongs to the ArsC family
A8P51_RS12790	COG1349	DNA-binding transcription factor activity
A8P51_RS12795	COG0446	pyridine nucleotide-disulphide oxidoreductase
A8P51_RS12800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A8P51_RS12810	COG0477	Major facilitator Superfamily
A8P51_RS12820	COG2217	Heavy metal translocating P-type atpase
A8P51_RS12840	COG1846	Transcriptional regulator
A8P51_RS12850	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A8P51_RS12850	COG0574	Belongs to the PEP-utilizing enzyme family
A8P51_RS12875	COG2384	SAM-dependent methyltransferase
A8P51_RS12880	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A8P51_RS12890	COG0542	response to heat
A8P51_RS12900	COG0587	DNA-directed DNA polymerase activity
A8P51_RS12905	COG0205	6-phosphofructokinase activity
A8P51_RS12920	COG2996	Protein conserved in bacteria
A8P51_RS12925	COG4974	Belongs to the 'phage' integrase family
A8P51_RS12935	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A8P51_RS12940	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A8P51_RS12945	COG1187	pseudouridine synthase activity
A8P51_RS12950	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
A8P51_RS12960	COG0514	ATP-dependent DNA helicase (RecQ)
A8P51_RS12970	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A8P51_RS12975	COG0539	negative regulation of cytoplasmic translation
A8P51_RS12980	COG1160	GTP binding
A8P51_RS12990	COG0457	Tetratricopeptide repeat
A8P51_RS12995	COG0561	phosphatase activity
A8P51_RS13000	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A8P51_RS13005	COG0617	tRNA 3'-terminal CCA addition
A8P51_RS13015	COG0488	(ABC) transporter
A8P51_RS13020	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A8P51_RS13025	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A8P51_RS13030	COG1307	EDD domain protein, DegV family
A8P51_RS13035	COG2755	lipolytic protein G-D-S-L family
A8P51_RS13040	COG4698	Protein conserved in bacteria
A8P51_RS13045	COG4479	Belongs to the UPF0346 family
A8P51_RS13050	COG0793	Belongs to the peptidase S41A family
A8P51_RS13050	COG3409	Peptidoglycan-binding domain 1 protein
A8P51_RS13055	COG2814	Major facilitator Superfamily
A8P51_RS13090	COG0583	DNA-binding transcription factor activity
A8P51_RS13095	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A8P51_RS13100	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A8P51_RS13105	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A8P51_RS13110	COG0758	DNA mediated transformation
A8P51_RS13115	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A8P51_RS13120	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
A8P51_RS13125	COG4974	Belongs to the 'phage' integrase family
A8P51_RS13130	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A8P51_RS13135	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A8P51_RS13145	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A8P51_RS13150	COG0187	DNA topoisomerase II activity
A8P51_RS13160	COG0583	DNA-binding transcription factor activity
A8P51_RS13165	COG1227	inorganic diphosphatase activity
A8P51_RS13170	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A8P51_RS13210	COG1846	Transcriptional regulator
A8P51_RS13225	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A8P51_RS13235	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A8P51_RS13245	COG1620	l-lactate permease
A8P51_RS13260	COG1113	amino acid transport
A8P51_RS13315	COG1307	EDD domain protein, DegV family
A8P51_RS13325	COG1293	RNA-binding protein homologous to eukaryotic snRNP
A8P51_RS13330	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A8P51_RS13335	COG1131	(ABC) transporter
A8P51_RS13360	COG5646	InterPro IPR014922
A8P51_RS13370	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A8P51_RS13375	COG0505	Belongs to the CarA family
A8P51_RS13380	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A8P51_RS13385	COG0564	pseudouridine synthase activity
A8P51_RS13390	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A8P51_RS13395	COG2759	Belongs to the formate--tetrahydrofolate ligase family
A8P51_RS13410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8P51_RS13440	COG1619	proteins homologs of microcin C7 resistance protein MccF
A8P51_RS13460	COG1216	Glycosyl transferase, family 2
A8P51_RS13470	COG1073	alpha beta
A8P51_RS13475	COG0477	Major facilitator Superfamily
A8P51_RS13485	COG0116	Belongs to the methyltransferase superfamily
A8P51_RS13495	COG3599	regulation of cell shape
A8P51_RS13500	COG4474	Belongs to the UPF0398 family
A8P51_RS13505	COG3331	DNA recombination
A8P51_RS13520	COG1840	ABC-type Fe3 transport system, periplasmic component
A8P51_RS13535	COG1464	Belongs to the NlpA lipoprotein family
A8P51_RS13540	COG2011	ABC-type metal ion transport system permease component
A8P51_RS13545	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A8P51_RS13560	COG0017	Asparaginyl-tRNA synthetase
A8P51_RS13575	COG1199	ATP-dependent helicase activity
A8P51_RS13575	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A8P51_RS13595	COG1304	FMN binding
A8P51_RS13600	COG2017	converts alpha-aldose to the beta-anomer
A8P51_RS13620	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A8P51_RS13620	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A8P51_RS13625	COG0561	phosphatase activity
A8P51_RS13630	COG0531	amino acid
A8P51_RS13665	COG1942	4-Oxalocrotonate Tautomerase
A8P51_RS13680	COG3237	CsbD-like
A8P51_RS13685	COG2261	transglycosylase associated protein
A8P51_RS13695	COG1597	lipid kinase activity
A8P51_RS13700	COG3152	Membrane
A8P51_RS13710	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
A8P51_RS13720	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
A8P51_RS13725	COG3397	chitin binding
A8P51_RS13730	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A8P51_RS13780	COG1162	GTPase activity
A8P51_RS13785	COG1607	acyl-coa hydrolase
A8P51_RS13790	COG0583	DNA-binding transcription factor activity
A8P51_RS13795	COG1811	Na channel or pump
A8P51_RS13805	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A8P51_RS13820	COG0439	Biotin carboxylase
A8P51_RS13835	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A8P51_RS13840	COG1028	Short-chain dehydrogenase reductase Sdr
A8P51_RS13845	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A8P51_RS13850	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8P51_RS13855	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A8P51_RS13860	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A8P51_RS13870	COG0300	oxidoreductase activity
A8P51_RS13880	COG1063	alcohol dehydrogenase
A8P51_RS13885	COG1473	amidohydrolase
A8P51_RS13910	COG0159	tryptophan synthase activity
A8P51_RS13915	COG0133	tryptophan synthase activity
A8P51_RS13920	COG0135	phosphoribosylanthranilate isomerase activity
A8P51_RS13925	COG0134	indole-3-glycerol-phosphate synthase activity
A8P51_RS13930	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A8P51_RS13935	COG0512	Glutamine amidotransferase of anthranilate synthase
A8P51_RS13935	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A8P51_RS13950	COG1131	(ABC) transporter
A8P51_RS13970	COG0335	large ribosomal subunit rRNA binding
A8P51_RS13975	COG0336	Belongs to the RNA methyltransferase TrmD family
A8P51_RS13980	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A8P51_RS13985	COG1837	Belongs to the UPF0109 family
A8P51_RS13990	COG0228	four-way junction DNA binding
A8P51_RS13995	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A8P51_RS14000	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
A8P51_RS14005	COG0552	protein localization to endoplasmic reticulum
A8P51_RS14010	COG1196	nuclear chromosome segregation
A8P51_RS14015	COG0571	ribonuclease III activity
A8P51_RS14020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8P51_RS14025	COG0416	fatty acid biosynthetic process
A8P51_RS14030	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A8P51_RS14035	COG1461	Dihydroxyacetone kinase
A8P51_RS14040	COG1302	Protein conserved in bacteria
A8P51_RS14045	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A8P51_RS14050	COG1564	THIamine pyrophosphokinase
A8P51_RS14055	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A8P51_RS14060	COG1162	GTPase activity
A8P51_RS14065	COG2815	serine threonine protein kinase
A8P51_RS14065	COG0515	serine threonine protein kinase
A8P51_RS14070	COG0631	protein serine/threonine phosphatase activity
A8P51_RS14075	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A8P51_RS14075	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A8P51_RS14080	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A8P51_RS14085	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A8P51_RS14090	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A8P51_RS14095	COG1758	RNA polymerase activity
A8P51_RS14100	COG0194	GDP metabolic process
A8P51_RS14115	COG1732	Glycine betaine
A8P51_RS14130	COG0497	DNA recombination
A8P51_RS14135	COG1438	arginine binding
A8P51_RS14140	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A8P51_RS14145	COG0142	geranyltranstransferase activity
A8P51_RS14150	COG1722	exodeoxyribonuclease VII activity
A8P51_RS14155	COG1570	exodeoxyribonuclease VII activity
A8P51_RS14160	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A8P51_RS14165	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A8P51_RS14170	COG1302	Protein conserved in bacteria
A8P51_RS14175	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A8P51_RS14180	COG0006	proline dipeptidase activity
A8P51_RS14185	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A8P51_RS14195	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A8P51_RS14240	COG0789	Transcriptional regulator
A8P51_RS14245	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A8P51_RS14250	COG0584	glycerophosphoryl diester phosphodiesterase
A8P51_RS14270	COG1940	carbohydrate kinase activity
A8P51_RS14280	COG0705	Rhomboid family
A8P51_RS14280	COG0457	Tetratricopeptide repeat
A8P51_RS14285	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A8P51_RS14290	COG0768	penicillin binding
A8P51_RS14300	COG4841	protein insertion into membrane
A8P51_RS14315	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A8P51_RS14320	COG0572	uridine kinase
A8P51_RS14325	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A8P51_RS14330	COG0072	phenylalanine-tRNA ligase activity
A8P51_RS14330	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A8P51_RS14335	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A8P51_RS14340	COG1733	regulation of RNA biosynthetic process
A8P51_RS14350	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A8P51_RS14355	COG1254	Belongs to the acylphosphatase family
A8P51_RS14360	COG0706	membrane insertase activity
A8P51_RS14375	COG0419	ATPase involved in DNA repair
A8P51_RS14390	COG5002	protein histidine kinase activity
A8P51_RS14395	COG0745	RESPONSE REGULATOR receiver
A8P51_RS14400	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A8P51_RS14405	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A8P51_RS14425	COG1323	Belongs to the UPF0348 family
A8P51_RS14430	COG2226	methyltransferase
A8P51_RS14435	COG0799	negative regulation of ribosome biogenesis
A8P51_RS14440	COG1713	HD superfamily hydrolase involved in NAD metabolism
A8P51_RS14445	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A8P51_RS14450	COG1534	Rna-binding protein
A8P51_RS14455	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A8P51_RS14470	COG1215	transferase activity, transferring glycosyl groups
A8P51_RS14480	COG1733	regulation of RNA biosynthetic process
A8P51_RS14485	COG0604	alcohol dehydrogenase
A8P51_RS14490	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A8P51_RS14500	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A8P51_RS14505	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A8P51_RS14510	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A8P51_RS14515	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A8P51_RS14520	COG1484	DNA-dependent DNA replication
A8P51_RS14525	COG3611	Membrane attachment protein
A8P51_RS14530	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A8P51_RS14535	COG0237	dephospho-CoA kinase activity
A8P51_RS14540	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A8P51_RS14545	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A8P51_RS14545	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A8P51_RS14560	COG2151	metal-sulfur cluster biosynthetic enzyme
A8P51_RS14565	COG0719	Fe-S assembly protein
A8P51_RS14575	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A8P51_RS14580	COG0719	Fe-S assembly protein
A8P51_RS14600	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A8P51_RS14605	COG1674	ftsk spoiiie
A8P51_RS14610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A8P51_RS14620	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A8P51_RS14625	COG0510	thiamine kinase activity
A8P51_RS14630	COG4473	ABC transporter
A8P51_RS14635	COG1131	(ABC) transporter
A8P51_RS14640	COG0537	adenosine 5'-monophosphoramidase activity
A8P51_RS14650	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A8P51_RS14680	COG0446	pyridine nucleotide-disulphide oxidoreductase
A8P51_RS14690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A8P51_RS14705	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A8P51_RS14710	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A8P51_RS14710	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A8P51_RS14715	COG0307	riboflavin synthase, alpha
A8P51_RS14720	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A8P51_RS14720	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A8P51_RS14740	COG0463	Glycosyl transferase, family 2
A8P51_RS14755	COG1053	succinate dehydrogenase
A8P51_RS14755	COG0431	NADPH-dependent FMN reductase
A8P51_RS14755	COG3976	FMN-binding domain protein
A8P51_RS14765	COG0583	DNA-binding transcription factor activity
A8P51_RS14780	COG3481	metal-dependent phosphohydrolase, HD sub domain
A8P51_RS14785	COG4717	serine-type aminopeptidase activity
A8P51_RS14790	COG0420	3'-5' exonuclease activity
A8P51_RS14795	COG3679	Belongs to the UPF0342 family
A8P51_RS14800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A8P51_RS14805	COG1438	arginine binding
A8P51_RS14810	COG0436	Aminotransferase
A8P51_RS14820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8P51_RS14825	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8P51_RS14830	COG1376	ErfK ybiS ycfS ynhG family protein
A8P51_RS14840	COG2723	6-phospho-beta-galactosidase activity
A8P51_RS14845	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A8P51_RS14850	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A8P51_RS14855	COG1447	Phosphotransferase system cellobiose-specific component IIA
A8P51_RS14875	COG0577	efflux transmembrane transporter activity
A8P51_RS14875	COG1136	(ABC) transporter
A8P51_RS14885	COG0018	arginyl-trna synthetase
A8P51_RS14890	COG2153	protein acetylation
A8P51_RS14910	COG0534	Mate efflux family protein
A8P51_RS14915	COG0471	metal ion transport
A8P51_RS14915	COG3273	potassium ion transport
A8P51_RS14925	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A8P51_RS14930	COG0529	Catalyzes the synthesis of activated sulfate
A8P51_RS14935	COG2046	Belongs to the sulfate adenylyltransferase family
A8P51_RS14945	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A8P51_RS14950	COG0646	methionine synthase
A8P51_RS14950	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A8P51_RS15070	COG0740	serine-type endopeptidase activity
A8P51_RS15245	COG0582	viral genome integration into host DNA
A8P51_RS15325	COG2801	Transposase and inactivated derivatives
A8P51_RS15340	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A8P51_RS15365	COG1418	mRNA catabolic process
A8P51_RS15370	COG0477	Major facilitator Superfamily
A8P51_RS15385	COG3328	transposase activity
A8P51_RS15390	COG0745	RESPONSE REGULATOR receiver
A8P51_RS15395	COG3158	transport of potassium into the cell
A8P51_RS15420	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A8P51_RS15430	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A8P51_RS15445	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A8P51_RS15495	COG0492	ferredoxin-NADP+ reductase activity
A8P51_RS15505	COG3118	belongs to the thioredoxin family
A8P51_RS15520	COG1846	Transcriptional regulator
A8P51_RS15550	COG0531	amino acid
A8P51_RS15600	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A8P51_RS15625	COG0551	DNA topoisomerase type I activity
A8P51_RS15625	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A8P51_RS15670	COG2801	Transposase and inactivated derivatives
A8P51_RS15705	COG3716	PTS system mannose fructose sorbose family IID component
A8P51_RS15745	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A8P51_RS15915	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A8P51_RS16300	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A8P51_RS16305	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A8P51_RS16425	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A8P51_RS16430	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection