locus-tag	class	description
S100434_RS00005	COG0230	Belongs to the bacterial ribosomal protein bL34 family
S100434_RS00010	COG0594	ribonuclease P activity
S100434_RS00015	COG0706	membrane insertase activity
S100434_RS00020	COG4166	transmembrane transport
S100434_RS00030	COG1847	R3H domain protein
S100434_RS00035	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
S100434_RS00040	COG0445	tRNA wobble uridine modification
S100434_RS00080	COG1307	EDD domain protein, DegV family
S100434_RS00095	COG3479	Phenolic acid decarboxylase
S100434_RS00100	COG1695	Transcriptional regulator
S100434_RS00110	COG1454	alcohol dehydrogenase
S100434_RS00110	COG1012	belongs to the aldehyde dehydrogenase family
S100434_RS00115	COG1609	Transcriptional regulator
S100434_RS00125	COG1869	D-ribose catabolic process
S100434_RS00130	COG4975	Glucose uptake
S100434_RS00150	COG3730	PTS system glucitol sorbitol-specific
S100434_RS00155	COG3732	PTS system glucitol sorbitol-specific
S100434_RS00170	COG2188	Transcriptional regulator
S100434_RS00175	COG1132	(ABC) transporter
S100434_RS00180	COG1132	(ABC) transporter
S100434_RS00185	COG2207	Transcriptional regulator
S100434_RS00185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S100434_RS00200	COG0395	ABC-type sugar transport system, permease component
S100434_RS00205	COG1653	transport
S100434_RS00210	COG0366	Alpha amylase catalytic
S100434_RS00220	COG2972	Histidine kinase
S100434_RS00225	COG2207	Transcriptional regulator
S100434_RS00225	COG4753	response regulator
S100434_RS00235	COG3842	ATPase activity
S100434_RS00245	COG2188	Transcriptional regulator
S100434_RS00255	COG0383	alpha-mannosidase activity
S100434_RS00260	COG1940	carbohydrate kinase activity
S100434_RS00265	COG2723	6-phospho-beta-galactosidase activity
S100434_RS00270	COG0366	Alpha amylase catalytic
S100434_RS00280	COG1609	Transcriptional regulator
S100434_RS00290	COG1263	PTS System
S100434_RS00290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100434_RS00310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100434_RS00310	COG1263	PTS System
S100434_RS00315	COG1737	Transcriptional regulator
S100434_RS00335	COG2190	(PTS) system
S100434_RS00335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100434_RS00335	COG1263	PTS System
S100434_RS00350	COG3775	system Galactitol-specific IIC component
S100434_RS00365	COG1349	DNA-binding transcription factor activity
S100434_RS00370	COG2207	Transcriptional regulator
S100434_RS00375	COG2814	Major facilitator Superfamily
S100434_RS00380	COG1070	Carbohydrate kinase
S100434_RS00385	COG3254	rhamnose metabolic process
S100434_RS00390	COG4806	L-rhamnose isomerase
S100434_RS00395	COG0235	Class ii aldolase
S100434_RS00410	COG0028	Belongs to the TPP enzyme family
S100434_RS00415	COG1959	2 iron, 2 sulfur cluster binding
S100434_RS00420	COG0028	Belongs to the TPP enzyme family
S100434_RS00425	COG1304	FMN binding
S100434_RS00440	COG4512	PFAM Accessory gene regulator B
S100434_RS00460	COG1393	Belongs to the ArsC family
S100434_RS00470	COG2261	transglycosylase associated protein
S100434_RS00500	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
S100434_RS00505	COG1609	Transcriptional regulator
S100434_RS00525	COG2160	L-arabinose isomerase activity
S100434_RS00530	COG0110	maltose O-acetyltransferase activity
S100434_RS00540	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
S100434_RS00545	COG1349	DNA-binding transcription factor activity
S100434_RS00555	COG3414	Phosphotransferase system galactitol-specific IIB component
S100434_RS00560	COG3775	system Galactitol-specific IIC component
S100434_RS00570	COG3711	transcriptional antiterminator
S100434_RS00585	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S100434_RS00590	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S100434_RS00590	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S100434_RS00590	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
S100434_RS00595	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
S100434_RS00600	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
S100434_RS00615	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
S100434_RS00630	COG2211	Major facilitator Superfamily
S100434_RS00650	COG1263	PTS System
S100434_RS00650	COG2190	(PTS) system
S100434_RS00650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100434_RS00655	COG2723	6-phospho-beta-galactosidase activity
S100434_RS00660	COG2723	6-phospho-beta-galactosidase activity
S100434_RS00665	COG3711	transcriptional antiterminator
S100434_RS00675	COG2723	6-phospho-beta-galactosidase activity
S100434_RS00685	COG2971	BadF BadG BcrA BcrD
S100434_RS00690	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
S100434_RS00695	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100434_RS00700	COG2188	Transcriptional regulator
S100434_RS00715	COG2271	Major facilitator Superfamily
S100434_RS00730	COG1028	Short-chain dehydrogenase reductase Sdr
S100434_RS00745	COG2271	Major facilitator Superfamily
S100434_RS00750	COG0583	DNA-binding transcription factor activity
S100434_RS00755	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
S100434_RS00760	COG0710	3-dehydroquinate dehydratase activity
S100434_RS00780	COG0667	Aldo Keto reductase
S100434_RS00785	COG1609	Transcriptional regulator
S100434_RS00790	COG2017	converts alpha-aldose to the beta-anomer
S100434_RS00795	COG2190	(PTS) system
S100434_RS00795	COG2211	Major facilitator Superfamily
S100434_RS00815	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
S100434_RS00820	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
S100434_RS00825	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
S100434_RS00830	COG1609	Transcriptional regulator
S100434_RS00835	COG2944	sequence-specific DNA binding
S100434_RS00840	COG2184	nucleotidyltransferase activity
S100434_RS00860	COG0477	Major facilitator Superfamily
S100434_RS00870	COG1609	Transcriptional regulator
S100434_RS00875	COG1874	Beta-galactosidase
S100434_RS00885	COG1114	Component of the transport system for branched-chain amino acids
S100434_RS00895	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
S100434_RS00945	COG0446	pyridine nucleotide-disulphide oxidoreductase
S100434_RS00970	COG3590	peptidase
S100434_RS00975	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S100434_RS00995	COG1937	Protein conserved in bacteria
S100434_RS01000	COG3118	belongs to the thioredoxin family
S100434_RS01005	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
S100434_RS01010	COG2217	Heavy metal translocating P-type atpase
S100434_RS01030	COG2226	methyltransferase
S100434_RS01080	COG0076	glutamate decarboxylase activity
S100434_RS01105	COG2207	Transcriptional regulator
S100434_RS01140	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
S100434_RS01145	COG1968	undecaprenyl-diphosphatase activity
S100434_RS01165	COG0656	L-ascorbic acid biosynthetic process
S100434_RS01175	COG0737	Belongs to the 5'-nucleotidase family
S100434_RS01240	COG0477	Major facilitator Superfamily
S100434_RS01265	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
S100434_RS01280	COG0697	spore germination
S100434_RS01305	COG0071	Belongs to the small heat shock protein (HSP20) family
S100434_RS01320	COG1194	a g-specific adenine glycosylase
S100434_RS01330	COG3189	MarR family transcriptional regulator
S100434_RS01335	COG1393	Belongs to the ArsC family
S100434_RS01350	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
S100434_RS01360	COG1113	amino acid transport
S100434_RS01365	COG1757	Na H antiporter
S100434_RS01375	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
S100434_RS01380	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
S100434_RS01390	COG2315	Protein conserved in bacteria
S100434_RS01400	COG2217	Heavy metal translocating P-type atpase
S100434_RS01435	COG4989	oxidoreductase activity
S100434_RS01440	COG2151	metal-sulfur cluster biosynthetic enzyme
S100434_RS01450	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
S100434_RS01455	COG1882	Formate acetyltransferase
S100434_RS01460	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S100434_RS01495	COG2814	Major facilitator Superfamily
S100434_RS01500	COG0803	Belongs to the bacterial solute-binding protein 9 family
S100434_RS01520	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
S100434_RS01525	COG0302	gtp cyclohydrolase
S100434_RS01535	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
S100434_RS01575	COG0640	Transcriptional regulator
S100434_RS01580	COG1272	protein, Hemolysin III
S100434_RS01595	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S100434_RS01600	COG0628	permease
S100434_RS01605	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
S100434_RS01610	COG3158	transport of potassium into the cell
S100434_RS01615	COG0531	amino acid
S100434_RS01625	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
S100434_RS01630	COG2365	Tyrosine phosphatase family
S100434_RS01635	COG0516	GMP reductase activity
S100434_RS01640	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
S100434_RS01645	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
S100434_RS01660	COG1929	Belongs to the glycerate kinase type-1 family
S100434_RS01670	COG1562	ergosterol biosynthetic process
S100434_RS01675	COG1233	COG1233 Phytoene dehydrogenase and related
S100434_RS01680	COG2738	Putative neutral zinc metallopeptidase
S100434_RS01690	COG1307	EDD domain protein, DegV family
S100434_RS01700	COG1380	Effector of murein hydrolase LrgA
S100434_RS01725	COG0735	belongs to the Fur family
S100434_RS01755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100434_RS01755	COG2190	(PTS) system
S100434_RS01755	COG1263	PTS System
S100434_RS01770	COG0561	phosphatase activity
S100434_RS01785	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
S100434_RS01790	COG4619	ABC transporter
S100434_RS01795	COG0390	transport system, permease component
S100434_RS01810	COG1609	Transcriptional regulator
S100434_RS01815	COG0366	Alpha amylase catalytic
S100434_RS01820	COG1263	PTS System
S100434_RS01820	COG2190	(PTS) system
S100434_RS01820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100434_RS01845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S100434_RS01850	COG1126	abc transporter atp-binding protein
S100434_RS01855	COG0765	amino acid transport
S100434_RS01860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S100434_RS01865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S100434_RS01870	COG0583	DNA-binding transcription factor activity
S100434_RS01880	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
S100434_RS01885	COG0357	Ribosomal RNA small subunit methyltransferase G
S100434_RS01895	COG1192	Involved in chromosome partitioning
S100434_RS01900	COG1475	DNA binding
S100434_RS01905	COG4481	Protein conserved in bacteria
S100434_RS01910	COG0012	GTP binding
S100434_RS01920	COG0517	IMP dehydrogenase activity
S100434_RS01920	COG0516	GMP reductase activity
S100434_RS01925	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S100434_RS01945	COG1686	Belongs to the peptidase S11 family
S100434_RS01950	COG1247	-acetyltransferase
S100434_RS01990	COG2815	serine threonine protein kinase
S100434_RS01990	COG0515	serine threonine protein kinase
S100434_RS02000	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
S100434_RS02010	COG1846	Transcriptional regulator
S100434_RS02010	COG1940	carbohydrate kinase activity
S100434_RS02015	COG0628	permease
S100434_RS02020	COG0588	phosphoglycerate mutase activity
S100434_RS02055	COG0477	Major facilitator Superfamily
S100434_RS02070	COG0656	L-ascorbic acid biosynthetic process
S100434_RS02075	COG1376	ErfK ybiS ycfS ynhG family protein
S100434_RS02090	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
S100434_RS02100	COG1136	(ABC) transporter
S100434_RS02100	COG0577	efflux transmembrane transporter activity
S100434_RS02150	COG0789	Transcriptional regulator
S100434_RS02175	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100434_RS02180	COG2723	6-phospho-beta-galactosidase activity
S100434_RS02190	COG0783	Belongs to the Dps family
S100434_RS02200	COG1053	succinate dehydrogenase
S100434_RS02210	COG2816	NAD+ diphosphatase activity
S100434_RS02220	COG0481	GTPase activity
S100434_RS02255	COG1028	Short-chain dehydrogenase reductase Sdr
S100434_RS02260	COG0110	maltose O-acetyltransferase activity
S100434_RS02265	COG4221	oxidoreductase activity
S100434_RS02275	COG1309	transcriptional regulator
S100434_RS02280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100434_RS02285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100434_RS02290	COG1120	ATPase activity
S100434_RS02295	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S100434_RS02305	COG0477	Major facilitator Superfamily
S100434_RS02310	COG0667	Aldo Keto reductase
S100434_RS02330	COG0300	oxidoreductase activity
S100434_RS02335	COG1733	regulation of RNA biosynthetic process
S100434_RS02350	COG1012	belongs to the aldehyde dehydrogenase family
S100434_RS02360	COG1309	transcriptional regulator
S100434_RS02375	COG3279	Response regulator of the LytR AlgR family
S100434_RS02380	COG0367	asparagine synthase
S100434_RS02390	COG2814	Major facilitator Superfamily
S100434_RS02395	COG1733	regulation of RNA biosynthetic process
S100434_RS02400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S100434_RS02440	COG1063	alcohol dehydrogenase
S100434_RS02500	COG2217	Heavy metal translocating P-type atpase
S100434_RS02530	COG0531	amino acid
S100434_RS02545	COG1028	Short-chain dehydrogenase reductase Sdr
S100434_RS02550	COG1473	amidohydrolase
S100434_RS02560	COG1132	(ABC) transporter
S100434_RS02565	COG1132	(ABC) transporter
S100434_RS02580	COG1028	Short-chain dehydrogenase reductase Sdr
S100434_RS02610	COG4221	oxidoreductase activity
S100434_RS02625	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S100434_RS02650	COG0803	Belongs to the bacterial solute-binding protein 9 family
S100434_RS02670	COG0741	lytic transglycosylase activity
S100434_RS02675	COG0789	Transcriptional regulator
S100434_RS02685	COG2723	6-phospho-beta-galactosidase activity
S100434_RS02690	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100434_RS02695	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100434_RS02730	COG0577	efflux transmembrane transporter activity
S100434_RS02730	COG1136	(ABC) transporter
S100434_RS02745	COG0640	Transcriptional regulator
S100434_RS02765	COG1914	H( )-stimulated, divalent metal cation uptake system
S100434_RS02775	COG2246	polysaccharide biosynthetic process
S100434_RS02780	COG5549	protein import
S100434_RS02780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S100434_RS02795	COG0559	Belongs to the binding-protein-dependent transport system permease family
S100434_RS02810	COG0410	ABC transporter
S100434_RS02815	COG0617	tRNA 3'-terminal CCA addition
S100434_RS02815	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
S100434_RS02815	COG3620	sequence-specific DNA binding
S100434_RS02845	COG4120	Belongs to the binding-protein-dependent transport system permease family
S100434_RS02855	COG2190	(PTS) system
S100434_RS02855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100434_RS02855	COG1263	PTS System
S100434_RS02860	COG0778	Nitroreductase
S100434_RS02870	COG1132	(ABC) transporter
S100434_RS02875	COG1940	carbohydrate kinase activity
S100434_RS02900	COG0697	spore germination
S100434_RS02960	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
S100434_RS02970	COG0583	DNA-binding transcription factor activity
S100434_RS02990	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
S100434_RS03000	COG0242	peptide deformylase activity
S100434_RS03010	COG1328	CTP reductase activity
S100434_RS03020	COG2200	EAL domain
S100434_RS03060	COG2270	Major facilitator Superfamily
S100434_RS03075	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
S100434_RS03085	COG0561	phosphatase activity
S100434_RS03090	COG0488	(ABC) transporter
S100434_RS03125	COG0640	Transcriptional regulator
S100434_RS03135	COG1511	domain protein
S100434_RS03135	COG1511	domain protein
S100434_RS03150	COG2814	Major facilitator Superfamily
S100434_RS03155	COG1132	(ABC) transporter
S100434_RS03160	COG1132	(ABC) transporter
S100434_RS03165	COG0667	Aldo Keto reductase
S100434_RS03175	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
S100434_RS03190	COG1011	Hydrolase
S100434_RS03195	COG0110	maltose O-acetyltransferase activity
S100434_RS03200	COG0589	response to stress
S100434_RS03210	COG1028	Short-chain dehydrogenase reductase Sdr
S100434_RS03215	COG1063	alcohol dehydrogenase
S100434_RS03225	COG0583	DNA-binding transcription factor activity
S100434_RS03250	COG0456	acetyltransferase
S100434_RS03275	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
S100434_RS03300	COG0789	Transcriptional regulator
S100434_RS03315	COG4221	oxidoreductase activity
S100434_RS03325	COG4152	abc transporter atp-binding protein
S100434_RS03335	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
S100434_RS03350	COG0438	transferase activity, transferring glycosyl groups
S100434_RS03360	COG0583	DNA-binding transcription factor activity
S100434_RS03365	COG2855	membrane
S100434_RS03370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100434_RS03380	COG2814	Major facilitator Superfamily
S100434_RS03390	COG2814	Major facilitator Superfamily
S100434_RS03435	COG1136	(ABC) transporter
S100434_RS03440	COG0577	efflux transmembrane transporter activity
S100434_RS03455	COG4978	Transcriptional regulator
S100434_RS03455	COG0789	Transcriptional regulator
S100434_RS03460	COG1811	Na channel or pump
S100434_RS03480	COG4990	cell redox homeostasis
S100434_RS03495	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
S100434_RS03500	COG4720	Psort location CytoplasmicMembrane, score
S100434_RS03545	COG0531	amino acid
S100434_RS03550	COG0710	3-dehydroquinate dehydratase activity
S100434_RS03570	COG0716	FMN binding
S100434_RS03595	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
S100434_RS03600	COG0561	phosphatase activity
S100434_RS03615	COG1216	Glycosyl transferase, family 2
S100434_RS03620	COG2188	Transcriptional regulator
S100434_RS03625	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100434_RS03630	COG1447	Phosphotransferase system cellobiose-specific component IIA
S100434_RS03635	COG2723	6-phospho-beta-galactosidase activity
S100434_RS03640	COG2723	6-phospho-beta-galactosidase activity
S100434_RS03645	COG3048	D-serine ammonia-lyase activity
S100434_RS03650	COG1131	(ABC) transporter
S100434_RS03660	COG1309	transcriptional regulator
S100434_RS03665	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
S100434_RS03670	COG1827	regulation of RNA biosynthetic process
S100434_RS03705	COG0494	nUDIX hydrolase
S100434_RS03710	COG0110	maltose O-acetyltransferase activity
S100434_RS03720	COG0561	phosphatase activity
S100434_RS03730	COG0366	Alpha amylase catalytic
S100434_RS03750	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
S100434_RS03775	COG2246	polysaccharide biosynthetic process
S100434_RS03785	COG0589	response to stress
S100434_RS03795	COG1131	(ABC) transporter
S100434_RS03800	COG1725	Transcriptional regulator
S100434_RS03815	COG1136	(ABC) transporter
S100434_RS03835	COG2365	Tyrosine phosphatase family
S100434_RS03840	COG0095	Lipoate-protein ligase
S100434_RS03845	COG0431	NADPH-dependent FMN reductase
S100434_RS03845	COG1053	succinate dehydrogenase
S100434_RS03845	COG3976	FMN-binding domain protein
S100434_RS03850	COG1053	succinate dehydrogenase
S100434_RS03850	COG0431	NADPH-dependent FMN reductase
S100434_RS03850	COG3976	FMN-binding domain protein
S100434_RS03860	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
S100434_RS03865	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
S100434_RS03870	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
S100434_RS03875	COG0047	phosphoribosylformylglycinamidine synthase activity
S100434_RS03880	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
S100434_RS03890	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
S100434_RS03895	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
S100434_RS03900	COG0138	bifunctional purine biosynthesis protein purh
S100434_RS03905	COG0151	Belongs to the GarS family
S100434_RS03915	COG1215	transferase activity, transferring glycosyl groups
S100434_RS03935	COG2252	PERMEase
S100434_RS03940	COG2233	PERMEase
S100434_RS03945	COG2508	Transcriptional regulator
S100434_RS03950	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
S100434_RS03955	COG0540	Belongs to the ATCase OTCase family
S100434_RS03960	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
S100434_RS03965	COG0505	Belongs to the CarA family
S100434_RS03970	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
S100434_RS03975	COG0167	dihydroorotate dehydrogenase activity
S100434_RS03980	COG0284	orotidine-5'-phosphate decarboxylase activity
S100434_RS03985	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
S100434_RS03995	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
S100434_RS04000	COG1074	ATP-dependent DNA helicase activity
S100434_RS04010	COG0702	epimerase
S100434_RS04015	COG0583	DNA-binding transcription factor activity
S100434_RS04030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S100434_RS04035	COG0436	Aminotransferase
S100434_RS04040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S100434_RS04050	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
S100434_RS04060	COG0604	alcohol dehydrogenase
S100434_RS04065	COG0789	Transcriptional regulator
S100434_RS04070	COG2814	Major facilitator Superfamily
S100434_RS04075	COG0025	NhaP-type Na H and K H
S100434_RS04080	COG1780	Probably involved in ribonucleotide reductase function
S100434_RS04085	COG1253	flavin adenine dinucleotide binding
S100434_RS04115	COG1418	mRNA catabolic process
S100434_RS04125	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
S100434_RS04130	COG2188	Transcriptional regulator
S100434_RS04140	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
S100434_RS04155	COG1396	sequence-specific DNA binding
S100434_RS04160	COG4640	response to antibiotic
S100434_RS04175	COG0564	pseudouridine synthase activity
S100434_RS04180	COG0589	response to stress
S100434_RS04185	COG2188	Transcriptional regulator
S100434_RS04190	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100434_RS04195	COG3715	PTS system
S100434_RS04200	COG3716	PTS system mannose fructose sorbose family IID component
S100434_RS04210	COG1705	Flagellar rod assembly protein muramidase FlgJ
S100434_RS04215	COG0095	Lipoate-protein ligase
S100434_RS04245	COG0626	cystathionine gamma-synthase activity
S100434_RS04250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100434_RS04255	COG1073	alpha beta
S100434_RS04265	COG0028	Belongs to the TPP enzyme family
S100434_RS04305	COG1725	Transcriptional regulator
S100434_RS04310	COG1131	(ABC) transporter
S100434_RS04320	COG1335	isochorismatase
S100434_RS04330	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
S100434_RS04335	COG0025	NhaP-type Na H and K H
S100434_RS04340	COG0673	inositol 2-dehydrogenase activity
S100434_RS04345	COG0673	inositol 2-dehydrogenase activity
S100434_RS04355	COG1609	Transcriptional regulator
S100434_RS04365	COG0328	RNA-DNA hybrid ribonuclease activity
S100434_RS04375	COG0778	Nitroreductase
S100434_RS04380	COG2326	polyphosphate kinase activity
S100434_RS04395	COG0492	ferredoxin-NADP+ reductase activity
S100434_RS04405	COG0584	glycerophosphoryl diester phosphodiesterase
S100434_RS04410	COG1368	sulfuric ester hydrolase activity
S100434_RS04430	COG3548	integral membrane protein
S100434_RS04445	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
S100434_RS04455	COG0300	oxidoreductase activity
S100434_RS04460	COG0789	Transcriptional regulator
S100434_RS04480	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
S100434_RS04485	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
S100434_RS04490	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
S100434_RS04495	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
S100434_RS04500	COG0131	Imidazoleglycerol-phosphate dehydratase
S100434_RS04505	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
S100434_RS04510	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
S100434_RS04515	COG0107	imidazoleglycerol-phosphate synthase activity
S100434_RS04520	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
S100434_RS04525	COG0140	phosphoribosyl-ATP diphosphatase activity
S100434_RS04530	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
S100434_RS04535	COG0110	maltose O-acetyltransferase activity
S100434_RS04540	COG0861	Integral membrane protein TerC family
S100434_RS04545	COG2084	Dehydrogenase
S100434_RS04550	COG0446	pyridine nucleotide-disulphide oxidoreductase
S100434_RS04560	COG4120	Belongs to the binding-protein-dependent transport system permease family
S100434_RS04575	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
S100434_RS04580	COG2873	o-acetylhomoserine
S100434_RS04590	COG1307	EDD domain protein, DegV family
S100434_RS04595	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
S100434_RS04600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100434_RS04600	COG1263	PTS System
S100434_RS04600	COG2190	(PTS) system
S100434_RS04630	COG0488	(ABC) transporter
S100434_RS04650	COG1522	sequence-specific DNA binding
S100434_RS04655	COG0791	NLP P60 protein
S100434_RS04675	COG0477	Major facilitator Superfamily
S100434_RS04700	COG3830	Belongs to the UPF0237 family
S100434_RS04705	COG2848	UPF0210 protein
S100434_RS04710	COG0745	RESPONSE REGULATOR receiver
S100434_RS04715	COG5002	protein histidine kinase activity
S100434_RS04715	COG3850	Histidine kinase
S100434_RS04720	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
S100434_RS04725	COG4975	Glucose uptake
S100434_RS04730	COG0166	Belongs to the GPI family
S100434_RS04740	COG0577	efflux transmembrane transporter activity
S100434_RS04740	COG1136	(ABC) transporter
S100434_RS04750	COG1132	(ABC) transporter
S100434_RS04795	COG4932	domain protein
S100434_RS04795	COG4886	Leucine-rich repeat (LRR) protein
S100434_RS04840	COG0726	polysaccharide deacetylase
S100434_RS04855	COG1132	(ABC) transporter
S100434_RS04870	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S100434_RS04880	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S100434_RS04885	COG1482	cell wall glycoprotein biosynthetic process
S100434_RS04890	COG3442	glutamine amidotransferase
S100434_RS04895	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
S100434_RS04900	COG1435	thymidine kinase activity
S100434_RS04905	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
S100434_RS04910	COG2890	protein-(glutamine-N5) methyltransferase activity
S100434_RS04915	COG0009	L-threonylcarbamoyladenylate synthase
S100434_RS04920	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
S100434_RS04925	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
S100434_RS04935	COG2233	PERMEase
S100434_RS04940	COG0356	it plays a direct role in the translocation of protons across the membrane
S100434_RS04945	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
S100434_RS04950	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
S100434_RS04955	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
S100434_RS04960	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
S100434_RS04965	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
S100434_RS04970	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
S100434_RS04975	COG0355	proton-transporting ATP synthase activity, rotational mechanism
S100434_RS04980	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
S100434_RS04990	COG1077	Cell shape determining protein MreB Mrl
S100434_RS04995	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
S100434_RS05005	COG0772	Belongs to the SEDS family
S100434_RS05010	COG0509	glycine decarboxylation via glycine cleavage system
S100434_RS05015	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
S100434_RS05020	COG2011	ABC-type metal ion transport system permease component
S100434_RS05025	COG1464	Belongs to the NlpA lipoprotein family
S100434_RS05045	COG1181	Belongs to the D-alanine--D-alanine ligase family
S100434_RS05065	COG0589	response to stress
S100434_RS05080	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
S100434_RS05085	COG0189	ligase activity
S100434_RS05085	COG2918	glutathione biosynthetic process
S100434_RS05090	COG1609	Transcriptional regulator
S100434_RS05095	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100434_RS05100	COG3715	PTS system
S100434_RS05105	COG3716	PTS system mannose fructose sorbose family IID component
S100434_RS05120	COG0640	Transcriptional regulator
S100434_RS05135	COG4493	Belongs to the UPF0637 family
S100434_RS05140	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
S100434_RS05145	COG1956	GAF domain-containing protein
S100434_RS05150	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
S100434_RS05160	COG1104	cysteine desulfurase activity
S100434_RS05165	COG0301	tRNA thio-modification
S100434_RS05170	COG2918	glutathione biosynthetic process
S100434_RS05170	COG1181	Belongs to the D-alanine--D-alanine ligase family
S100434_RS05180	COG0525	valine-tRNA ligase activity
S100434_RS05185	COG0285	dihydrofolate synthase activity
S100434_RS05190	COG2003	Belongs to the UPF0758 family
S100434_RS05195	COG1077	Cell shape determining protein MreB Mrl
S100434_RS05200	COG1792	Involved in formation and maintenance of cell shape
S100434_RS05210	COG0850	regulation of cytokinetic process
S100434_RS05215	COG2894	cell division
S100434_RS05220	COG0765	amino acid transport
S100434_RS05225	COG1126	abc transporter atp-binding protein
S100434_RS05230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S100434_RS05240	COG0527	aspartate kinase activity
S100434_RS05245	COG0612	Peptidase, M16
S100434_RS05250	COG0612	Peptidase, M16
S100434_RS05255	COG1426	Protein conserved in bacteria
S100434_RS05260	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
S100434_RS05265	COG1058	Belongs to the CinA family
S100434_RS05265	COG1546	Belongs to the CinA family
S100434_RS05270	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
S100434_RS05275	COG1418	mRNA catabolic process
S100434_RS05280	COG1692	metallophosphoesterase
S100434_RS05285	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
S100434_RS05290	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
S100434_RS05320	COG0632	four-way junction helicase activity
S100434_RS05325	COG2255	four-way junction helicase activity
S100434_RS05330	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
S100434_RS05335	COG0343	queuine tRNA-ribosyltransferase activity
S100434_RS05340	COG1862	Preprotein translocase
S100434_RS05345	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S100434_RS05350	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
S100434_RS05355	COG0513	Belongs to the DEAD box helicase family
S100434_RS05360	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
S100434_RS05365	COG4472	Bacterial protein of unknown function (DUF965)
S100434_RS05370	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
S100434_RS05375	COG3906	Belongs to the UPF0473 family
S100434_RS05385	COG1193	negative regulation of DNA recombination
S100434_RS05390	COG3118	belongs to the thioredoxin family
S100434_RS05395	COG1719	4-vinyl reductase, 4VR
S100434_RS05400	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
S100434_RS05405	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
S100434_RS05415	COG0517	IMP dehydrogenase activity
S100434_RS05420	COG2171	N-acyltransferase activity
S100434_RS05425	COG1473	amidohydrolase
S100434_RS05430	COG0668	transmembrane transport
S100434_RS05445	COG0789	Transcriptional regulator
S100434_RS05450	COG0006	proline dipeptidase activity
S100434_RS05455	COG1609	Transcriptional regulator
S100434_RS05470	COG0217	transcriptional regulatory protein
S100434_RS05480	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
S100434_RS05510	COG0827	DNA restriction-modification system
S100434_RS05515	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
S100434_RS05520	COG1113	amino acid transport
S100434_RS05535	COG0737	Belongs to the 5'-nucleotidase family
S100434_RS05540	COG4470	Protein conserved in bacteria
S100434_RS05545	COG0647	UMP catabolic process
S100434_RS05555	COG0586	Pfam SNARE associated Golgi protein
S100434_RS05565	COG1098	S1 RNA binding domain
S100434_RS05705	COG1234	tRNA 3'-trailer cleavage
S100434_RS05710	COG1393	Belongs to the ArsC family
S100434_RS05715	COG4862	establishment of competence for transformation
S100434_RS05725	COG1164	Oligoendopeptidase f
S100434_RS05735	COG2357	RelA SpoT domain protein
S100434_RS05740	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
S100434_RS05745	COG0564	pseudouridine synthase activity
S100434_RS05750	COG3142	Participates in the control of copper homeostasis
S100434_RS05755	COG2706	6-phosphogluconolactonase activity
S100434_RS05765	COG0628	permease
S100434_RS05770	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
S100434_RS05785	COG1114	Component of the transport system for branched-chain amino acids
S100434_RS05795	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
S100434_RS05800	COG1674	ftsk spoiiie
S100434_RS05820	COG2001	Belongs to the MraZ family
S100434_RS05825	COG0275	rRNA processing
S100434_RS05835	COG0768	penicillin binding
S100434_RS05840	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S100434_RS05845	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
S100434_RS05850	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S100434_RS05855	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
S100434_RS05870	COG1799	cell septum assembly
S100434_RS05875	COG0762	integral membrane protein
S100434_RS05885	COG3599	regulation of cell shape
S100434_RS05890	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
S100434_RS05895	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
S100434_RS05900	COG0494	nUDIX hydrolase
S100434_RS05910	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
S100434_RS05915	COG1104	cysteine desulfurase activity
S100434_RS05925	COG0482	sulfurtransferase activity
S100434_RS05930	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
S100434_RS05935	COG0569	domain protein
S100434_RS05965	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
S100434_RS05970	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
S100434_RS05975	COG1388	LysM domain
S100434_RS05975	COG3584	3D domain protein
S100434_RS05985	COG1597	lipid kinase activity
S100434_RS05990	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
S100434_RS05995	COG5503	Protein of unknown function (DUF1447)
S100434_RS06005	COG0242	peptide deformylase activity
S100434_RS06030	COG0039	L-malate dehydrogenase activity
S100434_RS06035	COG4476	Belongs to the UPF0223 family
S100434_RS06040	COG0483	inositol monophosphate 1-phosphatase activity
S100434_RS06045	COG1217	gtp-binding protein TYPA
S100434_RS06080	COG0772	Belongs to the SEDS family
S100434_RS06085	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
S100434_RS06090	COG4471	UPF0298 protein
S100434_RS06095	COG0742	ribosomal rna small subunit methyltransferase
S100434_RS06100	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
S100434_RS06105	COG3480	Lon protease (S16) C-terminal proteolytic domain
S100434_RS06110	COG1555	photosystem II stabilization
S100434_RS06110	COG1596	polysaccharide export
S100434_RS06115	COG2131	deaminase
S100434_RS06120	COG0658	competence protein
S100434_RS06120	COG2333	competence protein COMEC
S100434_RS06125	COG1466	dna polymerase III delta subunit
S100434_RS06130	COG0268	Binds directly to 16S ribosomal RNA
S100434_RS06135	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
S100434_RS06160	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
S100434_RS06165	COG0544	peptidyl-prolyl cis-trans isomerase activity
S100434_RS06170	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
S100434_RS06175	COG0218	Necessary for normal cell division and for the maintenance of normal septation
S100434_RS06195	COG0765	amino acid transport
S100434_RS06200	COG1126	abc transporter atp-binding protein
S100434_RS06205	COG0322	excinuclease ABC activity
S100434_RS06215	COG0489	protein tyrosine kinase activity
S100434_RS06225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S100434_RS06230	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
S100434_RS06235	COG0297	glycogen (starch) synthase activity
S100434_RS06260	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
S100434_RS06265	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S100434_RS06265	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S100434_RS06265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100434_RS06270	COG1105	Belongs to the carbohydrate kinase PfkB family
S100434_RS06275	COG1349	DNA-binding transcription factor activity
S100434_RS06280	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
S100434_RS06290	COG1234	tRNA 3'-trailer cleavage
S100434_RS06295	COG0300	oxidoreductase activity
S100434_RS06300	COG5416	Lipopolysaccharide assembly protein A domain
S100434_RS06305	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
S100434_RS06305	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
S100434_RS06310	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S100434_RS06325	COG0393	Putative heavy-metal-binding
S100434_RS06385	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
S100434_RS06560	COG3953	SLT domain
S100434_RS06560	COG5280	Phage tail tape measure protein TP901
S100434_RS06615	COG0772	Belongs to the SEDS family
S100434_RS06625	COG1116	anion transmembrane transporter activity
S100434_RS06630	COG1316	TRANSCRIPTIONal
S100434_RS06640	COG0463	Glycosyl transferase, family 2
S100434_RS06655	COG3425	synthase
S100434_RS06665	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
S100434_RS06670	COG4224	UPF0291 protein
S100434_RS06675	COG3763	UPF0154 protein
S100434_RS06680	COG0204	Acyl-transferase
S100434_RS06685	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
S100434_RS06690	COG2827	Endonuclease containing a URI domain
S100434_RS06695	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S100434_RS06705	COG0052	Belongs to the universal ribosomal protein uS2 family
S100434_RS06710	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
S100434_RS06715	COG0528	UMP kinase activity
S100434_RS06720	COG0233	cytoplasmic translational termination
S100434_RS06725	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
S100434_RS06730	COG4589	Belongs to the CDS family
S100434_RS06735	COG0750	zinc metalloprotease
S100434_RS06740	COG0442	prolyl-tRNA aminoacylation
S100434_RS06745	COG2176	DNA-directed DNA polymerase activity
S100434_RS06750	COG0779	Required for maturation of 30S ribosomal subunits
S100434_RS06755	COG0195	Participates in both transcription termination and antitermination
S100434_RS06760	COG2740	Nucleic-acid-binding protein implicated in transcription termination
S100434_RS06770	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
S100434_RS06775	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
S100434_RS06780	COG0738	Major facilitator superfamily
S100434_RS06785	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
S100434_RS06795	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
S100434_RS06800	COG0287	Prephenate dehydrogenase
S100434_RS06805	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
S100434_RS06810	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
S100434_RS06815	COG0196	riboflavin kinase activity
S100434_RS06820	COG3527	Alpha-acetolactate decarboxylase
S100434_RS06825	COG1420	regulation of RNA biosynthetic process
S100434_RS06830	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
S100434_RS06835	COG0443	Heat shock 70 kDa protein
S100434_RS06840	COG0484	heat shock protein binding
S100434_RS06845	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S100434_RS06855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S100434_RS06860	COG1696	Membrane protein involved in D-alanine export
S100434_RS06865	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S100434_RS06870	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
S100434_RS06875	COG0481	GTPase activity
S100434_RS06890	COG2094	Belongs to the DNA glycosylase MPG family
S100434_RS06895	COG2264	protein methyltransferase activity
S100434_RS06900	COG1385	rRNA (uridine-N3-)-methyltransferase activity
S100434_RS06910	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
S100434_RS06915	COG1490	D-aminoacyl-tRNA deacylase activity
S100434_RS06920	COG0546	phosphoglycolate phosphatase activity
S100434_RS06925	COG3001	Fructosamine kinase
S100434_RS06930	COG0860	N-Acetylmuramoyl-L-alanine amidase
S100434_RS06930	COG4991	sh3 domain protein
S100434_RS06930	COG3103	Sh3 type 3 domain protein
S100434_RS06935	COG0124	histidyl-tRNA synthetase
S100434_RS06940	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
S100434_RS06950	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S100434_RS06960	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
S100434_RS06970	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
S100434_RS06975	COG0828	Belongs to the bacterial ribosomal protein bS21 family
S100434_RS06980	COG1610	YqeY-like protein
S100434_RS06985	COG1702	phosphate starvation-inducible protein PhoH
S100434_RS06990	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
S100434_RS06995	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
S100434_RS07000	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
S100434_RS07005	COG1381	Involved in DNA repair and RecF pathway recombination
S100434_RS07010	COG0752	glycyl-tRNA synthetase alpha subunit
S100434_RS07015	COG0751	glycine-tRNA ligase activity
S100434_RS07020	COG0358	DNA primase activity
S100434_RS07025	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
S100434_RS07035	COG1725	Transcriptional regulator
S100434_RS07040	COG1131	(ABC) transporter
S100434_RS07090	COG0519	Catalyzes the synthesis of GMP from XMP
S100434_RS07100	COG1131	(ABC) transporter
S100434_RS07110	COG4585	Histidine kinase
S100434_RS07115	COG2197	response regulator
S100434_RS07120	COG0446	pyridine nucleotide-disulphide oxidoreductase
S100434_RS07130	COG0604	alcohol dehydrogenase
S100434_RS07135	COG0583	DNA-binding transcription factor activity
S100434_RS07165	COG0546	phosphoglycolate phosphatase activity
S100434_RS07185	COG1393	Belongs to the ArsC family
S100434_RS07195	COG1349	DNA-binding transcription factor activity
S100434_RS07200	COG0446	pyridine nucleotide-disulphide oxidoreductase
S100434_RS07205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S100434_RS07215	COG0477	Major facilitator Superfamily
S100434_RS07220	COG0148	phosphopyruvate hydratase activity
S100434_RS07245	COG1846	Transcriptional regulator
S100434_RS07255	COG0574	Belongs to the PEP-utilizing enzyme family
S100434_RS07255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
S100434_RS07280	COG2384	SAM-dependent methyltransferase
S100434_RS07285	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
S100434_RS07295	COG0542	response to heat
S100434_RS07305	COG0587	DNA-directed DNA polymerase activity
S100434_RS07310	COG0205	6-phosphofructokinase activity
S100434_RS07335	COG2996	Protein conserved in bacteria
S100434_RS07340	COG4974	Belongs to the 'phage' integrase family
S100434_RS07350	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
S100434_RS07355	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
S100434_RS07360	COG1187	pseudouridine synthase activity
S100434_RS07365	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
S100434_RS07375	COG0514	ATP-dependent DNA helicase (RecQ)
S100434_RS07385	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
S100434_RS07390	COG0539	negative regulation of cytoplasmic translation
S100434_RS07395	COG1160	GTP binding
S100434_RS07410	COG0457	Tetratricopeptide repeat
S100434_RS07415	COG0561	phosphatase activity
S100434_RS07420	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
S100434_RS07425	COG0617	tRNA 3'-terminal CCA addition
S100434_RS07435	COG0488	(ABC) transporter
S100434_RS07440	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
S100434_RS07445	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
S100434_RS07450	COG1307	EDD domain protein, DegV family
S100434_RS07455	COG2755	lipolytic protein G-D-S-L family
S100434_RS07460	COG4698	Protein conserved in bacteria
S100434_RS07465	COG4479	Belongs to the UPF0346 family
S100434_RS07470	COG0793	Belongs to the peptidase S41A family
S100434_RS07470	COG3409	Peptidoglycan-binding domain 1 protein
S100434_RS07475	COG2814	Major facilitator Superfamily
S100434_RS07495	COG0583	DNA-binding transcription factor activity
S100434_RS07500	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S100434_RS07510	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
S100434_RS07515	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
S100434_RS07520	COG0758	DNA mediated transformation
S100434_RS07525	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
S100434_RS07530	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
S100434_RS07535	COG4974	Belongs to the 'phage' integrase family
S100434_RS07540	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
S100434_RS07545	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
S100434_RS07555	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
S100434_RS07560	COG0187	DNA topoisomerase II activity
S100434_RS07570	COG0583	DNA-binding transcription factor activity
S100434_RS07575	COG1227	inorganic diphosphatase activity
S100434_RS07580	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S100434_RS07620	COG1846	Transcriptional regulator
S100434_RS07635	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S100434_RS07645	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
S100434_RS07655	COG1620	l-lactate permease
S100434_RS07670	COG1113	amino acid transport
S100434_RS07730	COG1307	EDD domain protein, DegV family
S100434_RS07740	COG1293	RNA-binding protein homologous to eukaryotic snRNP
S100434_RS07750	COG1131	(ABC) transporter
S100434_RS07775	COG5646	InterPro IPR014922
S100434_RS07785	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
S100434_RS07790	COG0505	Belongs to the CarA family
S100434_RS07795	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
S100434_RS07800	COG0564	pseudouridine synthase activity
S100434_RS07805	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
S100434_RS07810	COG2759	Belongs to the formate--tetrahydrofolate ligase family
S100434_RS07825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S100434_RS07850	COG1619	proteins homologs of microcin C7 resistance protein MccF
S100434_RS07870	COG1216	Glycosyl transferase, family 2
S100434_RS07880	COG1073	alpha beta
S100434_RS07885	COG0116	Belongs to the methyltransferase superfamily
S100434_RS07895	COG3599	regulation of cell shape
S100434_RS07900	COG4474	Belongs to the UPF0398 family
S100434_RS07905	COG3331	DNA recombination
S100434_RS07920	COG1840	ABC-type Fe3 transport system, periplasmic component
S100434_RS07925	COG1177	transmembrane transport
S100434_RS07935	COG1464	Belongs to the NlpA lipoprotein family
S100434_RS07940	COG2011	ABC-type metal ion transport system permease component
S100434_RS07945	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
S100434_RS07960	COG0017	Asparaginyl-tRNA synthetase
S100434_RS07975	COG1199	ATP-dependent helicase activity
S100434_RS07975	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
S100434_RS08000	COG1304	FMN binding
S100434_RS08005	COG2017	converts alpha-aldose to the beta-anomer
S100434_RS08025	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
S100434_RS08025	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
S100434_RS08030	COG0561	phosphatase activity
S100434_RS08035	COG0531	amino acid
S100434_RS08075	COG1942	4-Oxalocrotonate Tautomerase
S100434_RS08090	COG3237	CsbD-like
S100434_RS08095	COG2261	transglycosylase associated protein
S100434_RS08110	COG1597	lipid kinase activity
S100434_RS08115	COG3152	Membrane
S100434_RS08125	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
S100434_RS08145	COG3397	chitin binding
S100434_RS08150	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
S100434_RS08170	COG0477	Major facilitator Superfamily
S100434_RS08180	COG1162	GTPase activity
S100434_RS08185	COG1607	acyl-coa hydrolase
S100434_RS08190	COG0583	DNA-binding transcription factor activity
S100434_RS08195	COG1811	Na channel or pump
S100434_RS08205	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
S100434_RS08220	COG0439	Biotin carboxylase
S100434_RS08235	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
S100434_RS08240	COG1028	Short-chain dehydrogenase reductase Sdr
S100434_RS08245	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
S100434_RS08250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S100434_RS08255	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S100434_RS08260	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
S100434_RS08270	COG0300	oxidoreductase activity
S100434_RS08280	COG1063	alcohol dehydrogenase
S100434_RS08285	COG1473	amidohydrolase
S100434_RS08295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100434_RS08310	COG0159	tryptophan synthase activity
S100434_RS08315	COG0133	tryptophan synthase activity
S100434_RS08320	COG0135	phosphoribosylanthranilate isomerase activity
S100434_RS08325	COG0134	indole-3-glycerol-phosphate synthase activity
S100434_RS08330	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
S100434_RS08335	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
S100434_RS08335	COG0512	Glutamine amidotransferase of anthranilate synthase
S100434_RS08370	COG0335	large ribosomal subunit rRNA binding
S100434_RS08375	COG0336	Belongs to the RNA methyltransferase TrmD family
S100434_RS08380	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
S100434_RS08385	COG1837	Belongs to the UPF0109 family
S100434_RS08390	COG0228	four-way junction DNA binding
S100434_RS08395	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
S100434_RS08400	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
S100434_RS08405	COG0552	protein localization to endoplasmic reticulum
S100434_RS08410	COG1196	nuclear chromosome segregation
S100434_RS08415	COG0571	ribonuclease III activity
S100434_RS08420	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S100434_RS08425	COG0416	fatty acid biosynthetic process
S100434_RS08430	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
S100434_RS08435	COG1461	Dihydroxyacetone kinase
S100434_RS08440	COG1302	Protein conserved in bacteria
S100434_RS08445	COG0227	Belongs to the bacterial ribosomal protein bL28 family
S100434_RS08450	COG1564	THIamine pyrophosphokinase
S100434_RS08455	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
S100434_RS08460	COG1162	GTPase activity
S100434_RS08465	COG0515	serine threonine protein kinase
S100434_RS08465	COG2815	serine threonine protein kinase
S100434_RS08470	COG0631	protein serine/threonine phosphatase activity
S100434_RS08475	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
S100434_RS08475	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S100434_RS08480	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
S100434_RS08485	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
S100434_RS08490	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
S100434_RS08495	COG1758	RNA polymerase activity
S100434_RS08500	COG0194	GDP metabolic process
S100434_RS08515	COG1732	Glycine betaine
S100434_RS08530	COG0497	DNA recombination
S100434_RS08535	COG1438	arginine binding
S100434_RS08540	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
S100434_RS08545	COG0142	geranyltranstransferase activity
S100434_RS08550	COG1722	exodeoxyribonuclease VII activity
S100434_RS08555	COG1570	exodeoxyribonuclease VII activity
S100434_RS08560	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
S100434_RS08565	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S100434_RS08570	COG1302	Protein conserved in bacteria
S100434_RS08575	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
S100434_RS08580	COG0006	proline dipeptidase activity
S100434_RS08585	COG0211	Belongs to the bacterial ribosomal protein bL27 family
S100434_RS08595	COG0261	This protein binds to 23S rRNA in the presence of protein L20
S100434_RS08645	COG0789	Transcriptional regulator
S100434_RS08650	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
S100434_RS08655	COG0584	glycerophosphoryl diester phosphodiesterase
S100434_RS08675	COG1940	carbohydrate kinase activity
S100434_RS08685	COG0457	Tetratricopeptide repeat
S100434_RS08685	COG0705	Rhomboid family
S100434_RS08690	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
S100434_RS08695	COG0267	Belongs to the bacterial ribosomal protein bL33 family
S100434_RS08700	COG0768	penicillin binding
S100434_RS08710	COG4841	protein insertion into membrane
S100434_RS08725	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
S100434_RS08730	COG0572	uridine kinase
S100434_RS08735	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
S100434_RS08740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S100434_RS08740	COG0072	phenylalanine-tRNA ligase activity
S100434_RS08745	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
S100434_RS08750	COG1733	regulation of RNA biosynthetic process
S100434_RS08760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
S100434_RS08765	COG1254	Belongs to the acylphosphatase family
S100434_RS08770	COG0706	membrane insertase activity
S100434_RS08785	COG0419	ATPase involved in DNA repair
S100434_RS08795	COG5002	protein histidine kinase activity
S100434_RS08800	COG0745	RESPONSE REGULATOR receiver
S100434_RS08805	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
S100434_RS08810	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
S100434_RS08825	COG0333	Belongs to the bacterial ribosomal protein bL32 family
S100434_RS08835	COG1323	Belongs to the UPF0348 family
S100434_RS08840	COG2226	methyltransferase
S100434_RS08845	COG0799	negative regulation of ribosome biogenesis
S100434_RS08850	COG1713	HD superfamily hydrolase involved in NAD metabolism
S100434_RS08855	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
S100434_RS08860	COG1534	Rna-binding protein
S100434_RS08865	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
S100434_RS08880	COG1215	transferase activity, transferring glycosyl groups
S100434_RS08890	COG1733	regulation of RNA biosynthetic process
S100434_RS08895	COG0604	alcohol dehydrogenase
S100434_RS08900	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
S100434_RS08910	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
S100434_RS08915	COG0291	Belongs to the bacterial ribosomal protein bL35 family
S100434_RS08920	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
S100434_RS08925	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
S100434_RS08930	COG1484	DNA-dependent DNA replication
S100434_RS08935	COG3611	Membrane attachment protein
S100434_RS08940	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
S100434_RS08945	COG0237	dephospho-CoA kinase activity
S100434_RS08950	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
S100434_RS08955	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S100434_RS08955	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S100434_RS08965	COG3655	Transcriptional regulator
S100434_RS08985	COG2181	nitrate reductase activity
S100434_RS08995	COG1140	nitrate reductase beta subunit
S100434_RS09000	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
S100434_RS09005	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
S100434_RS09015	COG0303	'Molybdopterin
S100434_RS09020	COG1763	Mo-molybdopterin cofactor biosynthetic process
S100434_RS09025	COG0315	cyclic pyranopterin monophosphate synthase activity
S100434_RS09050	COG2197	response regulator
S100434_RS09075	COG2151	metal-sulfur cluster biosynthetic enzyme
S100434_RS09080	COG2223	nitrite transmembrane transporter activity
S100434_RS09085	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
S100434_RS09100	COG0716	FMN binding
S100434_RS09105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100434_RS09110	COG1120	ATPase activity
S100434_RS09120	COG0719	Fe-S assembly protein
S100434_RS09130	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
S100434_RS09135	COG0719	Fe-S assembly protein
S100434_RS09160	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
S100434_RS09165	COG1674	ftsk spoiiie
S100434_RS09170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S100434_RS09180	COG0220	tRNA (guanine-N7-)-methyltransferase activity
S100434_RS09185	COG0510	thiamine kinase activity
S100434_RS09190	COG4473	ABC transporter
S100434_RS09195	COG1131	(ABC) transporter
S100434_RS09200	COG0537	adenosine 5'-monophosphoramidase activity
S100434_RS09210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S100434_RS09240	COG0446	pyridine nucleotide-disulphide oxidoreductase
S100434_RS09250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S100434_RS09265	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
S100434_RS09270	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
S100434_RS09270	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
S100434_RS09275	COG0307	riboflavin synthase, alpha
S100434_RS09280	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
S100434_RS09280	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
S100434_RS09300	COG0463	Glycosyl transferase, family 2
S100434_RS09310	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
S100434_RS09320	COG0148	phosphopyruvate hydratase activity
S100434_RS09325	COG2217	Heavy metal translocating P-type atpase
S100434_RS09365	COG3976	FMN-binding domain protein
S100434_RS09365	COG1053	succinate dehydrogenase
S100434_RS09365	COG0431	NADPH-dependent FMN reductase
S100434_RS09375	COG0583	DNA-binding transcription factor activity
S100434_RS09390	COG3481	metal-dependent phosphohydrolase, HD sub domain
S100434_RS09395	COG4717	serine-type aminopeptidase activity
S100434_RS09400	COG0420	3'-5' exonuclease activity
S100434_RS09405	COG3679	Belongs to the UPF0342 family
S100434_RS09410	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S100434_RS09420	COG1438	arginine binding
S100434_RS09425	COG0436	Aminotransferase
S100434_RS09435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S100434_RS09440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S100434_RS09450	COG1376	ErfK ybiS ycfS ynhG family protein
S100434_RS09460	COG2723	6-phospho-beta-galactosidase activity
S100434_RS09465	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100434_RS09470	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100434_RS09475	COG1447	Phosphotransferase system cellobiose-specific component IIA
S100434_RS09495	COG1136	(ABC) transporter
S100434_RS09495	COG0577	efflux transmembrane transporter activity
S100434_RS09505	COG0018	arginyl-trna synthetase
S100434_RS09510	COG2153	protein acetylation
S100434_RS09530	COG0534	Mate efflux family protein
S100434_RS09535	COG3273	potassium ion transport
S100434_RS09535	COG0471	metal ion transport
S100434_RS09545	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
S100434_RS09550	COG0529	Catalyzes the synthesis of activated sulfate
S100434_RS09555	COG2046	Belongs to the sulfate adenylyltransferase family
S100434_RS09565	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S100434_RS09570	COG0646	methionine synthase
S100434_RS09570	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
S100434_RS09610	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
S100434_RS09625	COG1846	Transcriptional regulator
S100434_RS09645	COG3279	Response regulator of the LytR AlgR family
S100434_RS09665	COG0561	phosphatase activity
S100434_RS09680	COG0789	Transcriptional regulator
S100434_RS09685	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S100434_RS09715	COG1511	domain protein
S100434_RS09715	COG1511	domain protein
S100434_RS09720	COG1970	mechanosensitive ion channel activity
S100434_RS09725	COG1428	Deoxynucleoside kinase
S100434_RS09730	COG0584	glycerophosphoryl diester phosphodiesterase
S100434_RS09740	COG0395	ABC-type sugar transport system, permease component
S100434_RS09745	COG1175	transmembrane transport
S100434_RS09750	COG3842	ATPase activity
S100434_RS09760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S100434_RS09765	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
S100434_RS09770	COG1187	pseudouridine synthase activity
S100434_RS09775	COG2244	polysaccharide biosynthetic process
S100434_RS09780	COG0495	leucyl-tRNA aminoacylation
S100434_RS09790	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
S100434_RS09810	COG0438	transferase activity, transferring glycosyl groups
S100434_RS09825	COG0477	Major facilitator Superfamily
S100434_RS09830	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
S100434_RS09840	COG0438	transferase activity, transferring glycosyl groups
S100434_RS09845	COG2040	homocysteine
S100434_RS09850	COG0833	amino acid
S100434_RS09855	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
S100434_RS09870	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
S100434_RS09890	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S100434_RS09980	COG1368	sulfuric ester hydrolase activity
S100434_RS09985	COG4703	Protein of unknown function (DUF1797)
S100434_RS09990	COG0436	Aminotransferase
S100434_RS09995	COG1686	Belongs to the peptidase S11 family
S100434_RS10005	COG0438	transferase activity, transferring glycosyl groups
S100434_RS10010	COG0438	transferase activity, transferring glycosyl groups
S100434_RS10030	COG0542	response to heat
S100434_RS10035	COG0582	viral genome integration into host DNA
S100434_RS10045	COG4608	Belongs to the ABC transporter superfamily
S100434_RS10050	COG0444	Belongs to the ABC transporter superfamily
S100434_RS10055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S100434_RS10060	COG0601	transmembrane transport
S100434_RS10065	COG4166	transmembrane transport
S100434_RS10095	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
S100434_RS10100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S100434_RS10105	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
S100434_RS10110	COG1070	Carbohydrate kinase
S100434_RS10115	COG2610	gluconate transmembrane transporter activity
S100434_RS10120	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
S100434_RS10125	COG0628	permease
S100434_RS10135	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S100434_RS10155	COG3557	Belongs to the UPF0374 family
S100434_RS10160	COG2137	regulation of response to DNA damage stimulus
S100434_RS10195	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
S100434_RS10240	COG0562	UDP-galactopyranose mutase
S100434_RS10360	COG4974	Belongs to the 'phage' integrase family
S100434_RS10400	COG5039	Polysaccharide pyruvyl transferase
S100434_RS10405	COG1215	transferase activity, transferring glycosyl groups
S100434_RS10425	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
S100434_RS10435	COG4464	protein tyrosine phosphatase activity
S100434_RS10440	COG0489	protein tyrosine kinase activity
S100434_RS10450	COG0582	viral genome integration into host DNA
S100434_RS10455	COG1088	dTDP-glucose 4,6-dehydratase activity
S100434_RS10475	COG0438	transferase activity, transferring glycosyl groups
S100434_RS10485	COG1442	glycosyl transferase family 8
S100434_RS10485	COG1216	Glycosyl transferase, family 2
S100434_RS10510	COG0562	UDP-galactopyranose mutase
S100434_RS10515	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
S100434_RS10525	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
S100434_RS10535	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
S100434_RS10565	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100434_RS10580	COG0513	Belongs to the DEAD box helicase family
S100434_RS10585	COG0673	inositol 2-dehydrogenase activity
S100434_RS10590	COG1278	Cold shock
S100434_RS10605	COG1737	Transcriptional regulator
S100434_RS10615	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100434_RS10630	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
S100434_RS10635	COG1597	lipid kinase activity
S100434_RS10640	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
S100434_RS10645	COG0154	amidase activity
S100434_RS10650	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
S100434_RS10655	COG4851	CamS sex pheromone cAM373 precursor
S100434_RS10660	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
S100434_RS10670	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
S100434_RS10675	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
S100434_RS10680	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S100434_RS10685	COG1705	Flagellar rod assembly protein muramidase FlgJ
S100434_RS10700	COG0142	geranyltranstransferase activity
S100434_RS10715	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
S100434_RS10720	COG4988	ABC transporter
S100434_RS10725	COG1294	oxidase, subunit
S100434_RS10730	COG1271	oxidase subunit
S100434_RS10745	COG4684	Psort location CytoplasmicMembrane, score
S100434_RS10750	COG0531	amino acid
S100434_RS10760	COG0281	malic enzyme
S100434_RS10765	COG0583	DNA-binding transcription factor activity
S100434_RS10770	COG0583	DNA-binding transcription factor activity
S100434_RS10780	COG1053	succinate dehydrogenase
S100434_RS10785	COG0114	fumarate hydratase activity
S100434_RS10810	COG2826	transposase and inactivated derivatives, IS30 family
S100434_RS10825	COG3052	prosthetic group binding
S100434_RS10845	COG0471	metal ion transport
S100434_RS10850	COG0039	L-malate dehydrogenase activity
S100434_RS10860	COG0803	Belongs to the bacterial solute-binding protein 9 family
S100434_RS10865	COG1108	ABC-type Mn2 Zn2 transport systems permease components
S100434_RS10870	COG1121	(ABC) transporter
S100434_RS10875	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
S100434_RS10880	COG4977	sequence-specific DNA binding
S100434_RS10880	COG1917	Cupin 2, conserved barrel domain protein
S100434_RS10890	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
S100434_RS10895	COG2151	metal-sulfur cluster biosynthetic enzyme
S100434_RS10900	COG0471	metal ion transport
S100434_RS10905	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
S100434_RS10910	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
S100434_RS10915	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
S100434_RS10920	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
S100434_RS10940	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
S100434_RS10945	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
S100434_RS10950	COG0101	tRNA pseudouridine synthase activity
S100434_RS10960	COG1122	ATPase activity
S100434_RS10965	COG1122	ATPase activity
S100434_RS10975	COG4939	FMN-binding domain protein
S100434_RS11000	COG0203	ribosomal protein L17
S100434_RS11005	COG0202	RNA polymerase activity
S100434_RS11010	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
S100434_RS11015	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
S100434_RS11020	COG0257	Belongs to the bacterial ribosomal protein bL36 family
S100434_RS11025	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
S100434_RS11030	COG0563	adenylate kinase activity
S100434_RS11040	COG0200	Binds to the 23S rRNA
S100434_RS11045	COG1841	ribosomal large subunit assembly
S100434_RS11050	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
S100434_RS11055	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
S100434_RS11060	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
S100434_RS11065	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
S100434_RS11070	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
S100434_RS11075	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
S100434_RS11080	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
S100434_RS11085	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
S100434_RS11090	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
S100434_RS11095	COG0255	Belongs to the universal ribosomal protein uL29 family
S100434_RS11100	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
S100434_RS11105	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
S100434_RS11110	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
S100434_RS11115	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
S100434_RS11120	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
S100434_RS11125	COG0089	rRNA binding
S100434_RS11130	COG0088	Forms part of the polypeptide exit tunnel
S100434_RS11135	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
S100434_RS11140	COG0051	transcription antitermination factor activity, RNA binding
S100434_RS11145	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
S100434_RS11150	COG0049	tRNA binding
S100434_RS11155	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
S100434_RS11160	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
S100434_RS11165	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
S100434_RS11170	COG0085	RNA polymerase activity
S100434_RS11180	COG0542	response to heat
S100434_RS11185	COG4463	regulation of RNA biosynthetic process
S100434_RS11225	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
S100434_RS11230	COG1428	Deoxynucleoside kinase
S100434_RS11240	COG0833	amino acid
S100434_RS11245	COG0028	Belongs to the TPP enzyme family
S100434_RS11250	COG1959	2 iron, 2 sulfur cluster binding
S100434_RS11270	COG1316	TRANSCRIPTIONal
S100434_RS11280	COG2966	Psort location CytoplasmicMembrane, score
S100434_RS11285	COG1278	Cold shock
S100434_RS11305	COG2814	Major facilitator Superfamily
S100434_RS11355	COG0367	asparagine synthase
S100434_RS11360	COG0527	aspartate kinase activity
S100434_RS11365	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
S100434_RS11390	COG0583	DNA-binding transcription factor activity
S100434_RS11395	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S100434_RS11405	COG2610	gluconate transmembrane transporter activity
S100434_RS11410	COG4948	Mandelate Racemase Muconate Lactonizing
S100434_RS11415	COG2706	6-phosphogluconolactonase activity
S100434_RS11450	COG0640	Transcriptional regulator
S100434_RS11455	COG0564	pseudouridine synthase activity
S100434_RS11460	COG0514	ATP-dependent DNA helicase (RecQ)
S100434_RS11480	COG4690	dipeptidase activity
S100434_RS11485	COG2502	aspartate--ammonia ligase
S100434_RS11490	COG0017	Asparaginyl-tRNA synthetase
S100434_RS11495	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
S100434_RS11505	COG1053	succinate dehydrogenase
S100434_RS11510	COG0583	DNA-binding transcription factor activity
S100434_RS11525	COG0572	uridine kinase
S100434_RS11545	COG0732	type I restriction modification DNA specificity domain
S100434_RS11570	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
S100434_RS11575	COG0308	aminopeptidase N
S100434_RS11605	COG1302	Protein conserved in bacteria
S100434_RS11620	COG2261	transglycosylase associated protein
S100434_RS11625	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
S100434_RS11625	COG2755	lipolytic protein G-D-S-L family
S100434_RS11640	COG2814	Major facilitator Superfamily
S100434_RS11645	COG1733	regulation of RNA biosynthetic process
S100434_RS11650	COG1266	CAAX protease self-immunity
S100434_RS11660	COG1396	sequence-specific DNA binding
S100434_RS11670	COG0518	GMP synthase (glutamine-hydrolyzing) activity
S100434_RS11670	COG0519	Catalyzes the synthesis of GMP from XMP
S100434_RS11675	COG1072	(Pantothenic acid kinase))
S100434_RS11680	COG2070	2-Nitropropane dioxygenase
S100434_RS11685	COG3973	AAA domain
S100434_RS11690	COG0586	Pfam SNARE associated Golgi protein
S100434_RS11695	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
S100434_RS11695	COG0456	acetyltransferase
S100434_RS11700	COG0569	domain protein
S100434_RS11700	COG0475	glutathione-regulated potassium exporter activity
S100434_RS11705	COG0588	phosphoglycerate mutase activity
S100434_RS11720	COG2076	Multidrug Resistance protein
S100434_RS11730	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
S100434_RS11760	COG1846	Transcriptional regulator
S100434_RS11770	COG0531	amino acid
S100434_RS11775	COG3394	polysaccharide catabolic process
S100434_RS11780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100434_RS11780	COG1263	PTS System
S100434_RS11790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100434_RS11790	COG2190	(PTS) system
S100434_RS11790	COG1263	PTS System
S100434_RS11795	COG0765	amino acid transport
S100434_RS11800	COG0765	amino acid transport
S100434_RS11805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S100434_RS11825	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S100434_RS11830	COG0436	Aminotransferase
S100434_RS11835	COG0546	phosphoglycolate phosphatase activity
S100434_RS11850	COG0735	belongs to the Fur family
S100434_RS11855	COG0194	GDP metabolic process
S100434_RS11880	COG0531	amino acid
S100434_RS11895	COG2936	dipeptidyl-peptidase activity
S100434_RS11900	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
S100434_RS11900	COG2755	lipolytic protein G-D-S-L family
S100434_RS11910	COG2267	carboxylic ester hydrolase activity
S100434_RS11915	COG0028	Belongs to the TPP enzyme family
S100434_RS11920	COG0196	riboflavin kinase activity
S100434_RS11925	COG0028	Belongs to the TPP enzyme family
S100434_RS11930	COG2252	PERMEase
S100434_RS11945	COG3475	LICD family
S100434_RS11955	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
S100434_RS11965	COG0477	Major facilitator Superfamily
S100434_RS11980	COG1393	Belongs to the ArsC family
S100434_RS11995	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
S100434_RS12015	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
S100434_RS12020	COG0778	Nitroreductase
S100434_RS12035	COG2017	converts alpha-aldose to the beta-anomer
S100434_RS12045	COG0561	phosphatase activity
S100434_RS12055	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
S100434_RS12060	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
S100434_RS12085	COG0025	NhaP-type Na H and K H
S100434_RS12090	COG0812	UDP-N-acetylmuramate dehydrogenase activity
S100434_RS12100	COG0708	Exodeoxyribonuclease III
S100434_RS12115	COG0802	atpase or kinase
S100434_RS12120	COG0280	phosphate acetyltransferase
S100434_RS12125	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
S100434_RS12130	COG0561	phosphatase activity
S100434_RS12140	COG1126	abc transporter atp-binding protein
S100434_RS12145	COG0765	amino acid transport
S100434_RS12160	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
S100434_RS12165	COG0557	exoribonuclease II activity
S100434_RS12175	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
S100434_RS12180	COG0038	chloride channel
S100434_RS12195	COG0148	phosphopyruvate hydratase activity
S100434_RS12200	COG0149	triose-phosphate isomerase activity
S100434_RS12205	COG0126	phosphoglycerate kinase activity
S100434_RS12215	COG2390	Transcriptional regulator
S100434_RS12220	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
S100434_RS12230	COG0740	serine-type endopeptidase activity
S100434_RS12235	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S100434_RS12245	COG1481	regulation of sporulation
S100434_RS12255	COG1660	Displays ATPase and GTPase activities
S100434_RS12265	COG0165	Argininosuccinate lyase
S100434_RS12270	COG0137	argininosuccinate synthase activity
S100434_RS12275	COG1854	S-ribosylhomocysteine lyase activity
S100434_RS12280	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
S100434_RS12285	COG0556	nucleotide-excision repair
S100434_RS12295	COG2814	Major facilitator Superfamily
S100434_RS12305	COG0446	pyridine nucleotide-disulphide oxidoreductase
S100434_RS12315	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
S100434_RS12325	COG2323	membrane
S100434_RS12330	COG0492	ferredoxin-NADP+ reductase activity
S100434_RS12335	COG0446	pyridine nucleotide-disulphide oxidoreductase
S100434_RS12345	COG1210	Utp--glucose-1-phosphate uridylyltransferase
S100434_RS12350	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
S100434_RS12355	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
S100434_RS12360	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
S100434_RS12365	COG1950	PFAM Membrane protein of
S100434_RS12370	COG1983	PspC domain protein
S100434_RS12375	COG0704	Plays a role in the regulation of phosphate uptake
S100434_RS12380	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S100434_RS12385	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S100434_RS12390	COG0581	inorganic phosphate transmembrane transporter activity
S100434_RS12395	COG0573	inorganic phosphate transmembrane transporter activity
S100434_RS12400	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
S100434_RS12405	COG5002	protein histidine kinase activity
S100434_RS12410	COG0745	RESPONSE REGULATOR receiver
S100434_RS12425	COG0653	protein targeting
S100434_RS12440	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
S100434_RS12445	COG1739	Uncharacterized protein family UPF0029
S100434_RS12450	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
S100434_RS12455	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S100434_RS12460	COG0531	amino acid
S100434_RS12465	COG0459	protein refolding
S100434_RS12470	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
S100434_RS12480	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
S100434_RS12485	COG0488	(ABC) transporter
S100434_RS12495	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
S100434_RS12500	COG0456	acetyltransferase
S100434_RS12505	COG0456	acetyltransferase
S100434_RS12510	COG1214	PFAM Peptidase M22, glycoprotease
S100434_RS12520	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
S100434_RS12530	COG3639	organic phosphonate transmembrane transporter activity
S100434_RS12535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S100434_RS12540	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
S100434_RS12545	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
S100434_RS12560	COG4467	Involved in initiation control of chromosome replication
S100434_RS12565	COG0470	DNA polymerase III
S100434_RS12570	COG3870	Protein conserved in bacteria
S100434_RS12575	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
S100434_RS12585	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
S100434_RS12590	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
S100434_RS12595	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
S100434_RS12610	COG2813	Specifically methylates the guanine in position
S100434_RS12615	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
S100434_RS12620	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S100434_RS12630	COG1611	Belongs to the LOG family
S100434_RS12650	COG0222	ribosome binding
S100434_RS12655	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
S100434_RS12660	COG0081	regulation of translation
S100434_RS12665	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
S100434_RS12675	COG0250	Participates in transcription elongation, termination and antitermination
S100434_RS12685	COG0267	Belongs to the bacterial ribosomal protein bL33 family
S100434_RS12700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
S100434_RS12705	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
S100434_RS12710	COG0215	cysteine-tRNA ligase activity
S100434_RS12715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
S100434_RS12720	COG4956	integral membrane protein (PIN domain superfamily)
S100434_RS12740	COG0756	dUTP diphosphatase activity
S100434_RS12750	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
S100434_RS12765	COG0588	phosphoglycerate mutase activity
S100434_RS12770	COG0697	spore germination
S100434_RS12780	COG1316	TRANSCRIPTIONal
S100434_RS12785	COG0825	malonyl-CoA metabolic process
S100434_RS12795	COG0439	Biotin carboxylase
S100434_RS12805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S100434_RS12810	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100434_RS12810	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100434_RS12815	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100434_RS12815	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100434_RS12820	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
S100434_RS12820	COG3933	PFAM sigma-54 factor interaction domain-containing protein
S100434_RS12830	COG3716	PTS system mannose fructose sorbose family IID component
S100434_RS12835	COG3715	PTS system
S100434_RS12875	COG0083	homoserine kinase activity
S100434_RS12880	COG0460	homoserine dehydrogenase
S100434_RS12885	COG3091	SprT-like family
S100434_RS12890	COG2183	response to ionizing radiation
S100434_RS12905	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
S100434_RS12910	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
S100434_RS12920	COG2188	Transcriptional regulator
S100434_RS12930	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S100434_RS12975	COG3104	oligopeptide transport
S100434_RS13020	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
S100434_RS13025	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
S100434_RS13030	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
S100434_RS13045	COG0037	tRNA processing
S100434_RS13050	COG1098	S1 RNA binding domain
S100434_RS13060	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
S100434_RS13065	COG2244	polysaccharide biosynthetic process
S100434_RS13070	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
S100434_RS13075	COG0193	aminoacyl-tRNA hydrolase activity
S100434_RS13080	COG0039	L-malate dehydrogenase activity
S100434_RS13100	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
S100434_RS13105	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
S100434_RS13110	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
S100434_RS13115	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
S100434_RS13120	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
S100434_RS13125	COG0505	Belongs to the CarA family
S100434_RS13130	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
S100434_RS13135	COG3158	transport of potassium into the cell
S100434_RS13140	COG2337	Toxic component of a toxin-antitoxin (TA) module
S100434_RS13145	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
S100434_RS13150	COG0736	holo-[acyl-carrier-protein] synthase activity
S100434_RS13175	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
S100434_RS13185	COG0501	Belongs to the peptidase M48B family
S100434_RS13190	COG1704	LemA family
S100434_RS13195	COG3764	Sortase (surface protein transpeptidase)
S100434_RS13210	COG0254	rRNA binding
S100434_RS13215	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
S100434_RS13220	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
S100434_RS13235	COG1760	l-serine dehydratase
S100434_RS13240	COG1760	l-serine dehydratase
S100434_RS13250	COG0814	amino acid
S100434_RS13255	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
S100434_RS13260	COG0504	CTP synthase activity
S100434_RS13265	COG3343	RNA polymerase activity
S100434_RS13275	COG0095	Lipoate-protein ligase
S100434_RS13280	COG1078	dGTPase activity
S100434_RS13300	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
S100434_RS13310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
S100434_RS13315	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S100434_RS13320	COG1108	ABC-type Mn2 Zn2 transport systems permease components
S100434_RS13320	COG1321	iron dependent repressor
S100434_RS13325	COG1121	(ABC) transporter
S100434_RS13330	COG1073	alpha beta
S100434_RS13335	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
S100434_RS13340	COG4466	Protein conserved in bacteria
S100434_RS13345	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
S100434_RS13350	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
S100434_RS13355	COG0084	hydrolase, TatD family'
S100434_RS13380	COG2814	Major facilitator Superfamily
S100434_RS13385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S100434_RS13385	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S100434_RS13395	COG1801	Protein of unknown function DUF72
S100434_RS13400	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
S100434_RS13415	COG0248	Ppx GppA phosphatase
S100434_RS13430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
S100434_RS13440	COG1940	carbohydrate kinase activity
S100434_RS13445	COG2723	6-phospho-beta-galactosidase activity
S100434_RS13450	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100434_RS13465	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100434_RS13470	COG2188	Transcriptional regulator
S100434_RS13475	COG0180	Tryptophanyl-tRNA synthetase
S100434_RS13480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
S100434_RS13485	COG3973	AAA domain
S100434_RS13520	COG2274	protein secretion by the type I secretion system
S100434_RS13545	COG3279	Response regulator of the LytR AlgR family
S100434_RS13570	COG0463	Glycosyl transferase, family 2
S100434_RS13615	COG1114	Component of the transport system for branched-chain amino acids
S100434_RS13620	COG0561	phosphatase activity
S100434_RS13630	COG0561	phosphatase activity
S100434_RS13640	COG0110	maltose O-acetyltransferase activity
S100434_RS13765	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
S100434_RS13775	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
S100434_RS13785	COG1125	glycine betaine transport
S100434_RS13805	COG0300	oxidoreductase activity
S100434_RS13835	COG1881	PFAM PEBP family protein
S100434_RS13840	COG3759	membrane
S100434_RS13850	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
S100434_RS13870	COG0004	ammonium transporteR
S100434_RS13875	COG2814	Major facilitator Superfamily
S100434_RS13890	COG1134	teichoic acid transport
S100434_RS13895	COG1682	transport, permease protein
S100434_RS13905	COG0436	Aminotransferase
S100434_RS13920	COG1268	BioY protein
S100434_RS13955	COG1012	belongs to the aldehyde dehydrogenase family
S100434_RS13955	COG1454	alcohol dehydrogenase
S100434_RS13965	COG1131	(ABC) transporter
S100434_RS13970	COG1725	Transcriptional regulator
S100434_RS14000	COG3842	ATPase activity
S100434_RS14040	COG1252	NADH dehydrogenase
S100434_RS14045	COG1846	Transcriptional regulator
S100434_RS14055	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
S100434_RS14085	COG1388	LysM domain
S100434_RS14085	COG3942	CHAP domain
S100434_RS14090	COG0741	lytic transglycosylase activity
S100434_RS14110	COG1136	(ABC) transporter
S100434_RS14115	COG0577	efflux transmembrane transporter activity
S100434_RS14125	COG2818	Glycosylase
S100434_RS14130	COG1033	growth of symbiont in host cell
S100434_RS14130	COG2409	Drug exporters of the RND superfamily
S100434_RS14140	COG2357	RelA SpoT domain protein
S100434_RS14150	COG0277	FAD linked oxidase domain protein
S100434_RS14155	COG1316	TRANSCRIPTIONal
S100434_RS14170	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100434_RS14175	COG1737	Transcriptional regulator
S100434_RS14185	COG0745	RESPONSE REGULATOR receiver
S100434_RS14190	COG5002	protein histidine kinase activity
S100434_RS14200	COG2814	Major facilitator Superfamily
S100434_RS14220	COG1914	H( )-stimulated, divalent metal cation uptake system
S100434_RS14225	COG1309	transcriptional regulator
S100434_RS14230	COG1959	2 iron, 2 sulfur cluster binding
S100434_RS14240	COG0163	prenyltransferase activity
S100434_RS14255	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S100434_RS14260	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S100434_RS14265	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
S100434_RS14275	COG2190	(PTS) system
S100434_RS14275	COG1263	PTS System
S100434_RS14275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100434_RS14280	COG2190	(PTS) system
S100434_RS14280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100434_RS14280	COG1263	PTS System
S100434_RS14285	COG0366	Alpha amylase catalytic
S100434_RS14290	COG2188	Transcriptional regulator
S100434_RS14320	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
S100434_RS14325	COG0626	cystathionine gamma-synthase activity
S100434_RS14330	COG1045	serine acetyltransferase
S100434_RS14350	COG3964	amidohydrolase
S100434_RS14365	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100434_RS14375	COG2188	Transcriptional regulator
S100434_RS14380	COG0431	NADPH-dependent FMN reductase
S100434_RS14410	COG3118	belongs to the thioredoxin family
S100434_RS14420	COG0246	Mannitol dehydrogenase
S100434_RS14425	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100434_RS14435	COG2213	PTS system mannitol-specific
S100434_RS14450	COG1053	succinate dehydrogenase
S100434_RS14450	COG3976	FMN-binding domain protein
S100434_RS14460	COG0363	glucosamine-6-phosphate deaminase activity
S100434_RS14475	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
S100434_RS14515	COG0386	Belongs to the glutathione peroxidase family
S100434_RS14525	COG4172	Belongs to the ABC transporter superfamily
S100434_RS14540	COG0488	(ABC) transporter
S100434_RS14545	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
S100434_RS14550	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
S100434_RS14580	COG0667	Aldo Keto reductase
S100434_RS14585	COG0406	alpha-ribazole phosphatase activity
S100434_RS14590	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
S100434_RS14595	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S100434_RS14605	COG4166	transmembrane transport
S100434_RS14610	COG4166	transmembrane transport
S100434_RS14635	COG1757	Na H antiporter
S100434_RS14690	COG3842	ATPase activity
S100434_RS14695	COG0366	Alpha amylase catalytic
S100434_RS14705	COG3833	ABC-type maltose transport systems, permease component
S100434_RS14710	COG1175	transmembrane transport
S100434_RS14715	COG2182	Extracellular solute-binding protein
S100434_RS14720	COG0366	Alpha amylase catalytic
S100434_RS14725	COG1609	Transcriptional regulator
S100434_RS14730	COG1609	Transcriptional regulator
S100434_RS14735	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
S100434_RS14740	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
S100434_RS14745	COG1461	Dihydroxyacetone kinase
S100434_RS14750	COG2376	Dihydroxyacetone kinase
S100434_RS14755	COG2376	Dihydroxyacetone kinase
S100434_RS14760	COG1309	transcriptional regulator
S100434_RS14765	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
S100434_RS14770	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
S100434_RS14785	COG1131	(ABC) transporter
S100434_RS14790	COG1028	Short-chain dehydrogenase reductase Sdr
S100434_RS14815	COG2188	Transcriptional regulator
S100434_RS14825	COG4720	Psort location CytoplasmicMembrane, score
S100434_RS14830	COG1122	ATPase activity
S100434_RS14835	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
S100434_RS14865	COG0667	Aldo Keto reductase
S100434_RS14870	COG0656	L-ascorbic acid biosynthetic process
S100434_RS14875	COG2807	transmembrane transport
S100434_RS14880	COG0640	Transcriptional regulator
S100434_RS14915	COG1983	PspC domain protein
S100434_RS14925	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
S100434_RS14930	COG2267	carboxylic ester hydrolase activity
S100434_RS14940	COG1113	amino acid transport
S100434_RS14955	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
S100434_RS14965	COG0352	thiamine-phosphate diphosphorylase activity
S100434_RS14970	COG0351	phosphomethylpyrimidine kinase
S100434_RS14975	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
S100434_RS14985	COG1606	tRNA processing
S100434_RS14990	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
S100434_RS14995	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
S100434_RS15000	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
S100434_RS15005	COG1691	(AIR) carboxylase
S100434_RS15010	COG3875	lactate racemase activity
S100434_RS15015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S100434_RS15020	COG0310	cobalt ion transport
S100434_RS15025	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
S100434_RS15030	COG1122	ATPase activity
S100434_RS15055	COG4166	transmembrane transport
S100434_RS15070	COG2267	carboxylic ester hydrolase activity
S100434_RS15100	COG0604	alcohol dehydrogenase
S100434_RS15135	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
S100434_RS15155	COG2368	4-hydroxyphenylacetate
S100434_RS15160	COG2365	Tyrosine phosphatase family
S100434_RS15170	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
S100434_RS15175	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S100434_RS15185	COG2508	Transcriptional regulator
S100434_RS15190	COG0778	Nitroreductase
S100434_RS15200	COG1028	Short-chain dehydrogenase reductase Sdr
S100434_RS15205	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
S100434_RS15220	COG0471	metal ion transport
S100434_RS15225	COG3976	FMN-binding domain protein
S100434_RS15225	COG0431	NADPH-dependent FMN reductase
S100434_RS15225	COG1053	succinate dehydrogenase
S100434_RS15245	COG1573	uracil-dna glycosylase
S100434_RS15305	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
S100434_RS15310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S100434_RS15315	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
S100434_RS15320	COG4853	Protein conserved in bacteria
S100434_RS15330	COG5002	protein histidine kinase activity
S100434_RS15335	COG0745	RESPONSE REGULATOR receiver
S100434_RS15350	COG1278	Cold shock
S100434_RS15360	COG1554	hydrolase, family 65, central catalytic
S100434_RS15365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S100434_RS15375	COG3103	Sh3 type 3 domain protein
S100434_RS15375	COG0366	Alpha amylase catalytic
S100434_RS15380	COG0058	SHG alpha-glucan phosphorylase activity
S100434_RS15385	COG0297	glycogen (starch) synthase activity
S100434_RS15390	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
S100434_RS15395	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
S100434_RS15400	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
S100434_RS15410	COG4166	transmembrane transport
S100434_RS15415	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
S100434_RS15420	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
S100434_RS15425	COG2814	Major facilitator Superfamily
S100434_RS15430	COG0305	Participates in initiation and elongation during chromosome replication
S100434_RS15435	COG0359	binds to the 23S rRNA
S100434_RS15445	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
S100434_RS15450	COG0629	single-stranded DNA binding
S100434_RS15455	COG0360	Binds together with S18 to 16S ribosomal RNA
S100434_RS15465	COG0187	DNA topoisomerase II activity
S100434_RS15470	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
S100434_RS15475	COG2501	S4 domain
S100434_RS15480	COG0592	DNA-directed DNA polymerase activity
S100434_RS15485	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids