locus-tag	class	description
LAC30SC_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LAC30SC_RS00010	COG0592	DNA-directed DNA polymerase activity
LAC30SC_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LAC30SC_RS00025	COG0187	DNA topoisomerase II activity
LAC30SC_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LAC30SC_RS00035	COG0360	Binds together with S18 to 16S ribosomal RNA
LAC30SC_RS00040	COG0629	single-stranded DNA binding
LAC30SC_RS00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LAC30SC_RS00055	COG0359	binds to the 23S rRNA
LAC30SC_RS00060	COG0305	Participates in initiation and elongation during chromosome replication
LAC30SC_RS00070	COG1307	EDD domain protein, DegV family
LAC30SC_RS00075	COG1940	carbohydrate kinase activity
LAC30SC_RS00080	COG3237	CsbD-like
LAC30SC_RS00095	COG1285	pathogenesis
LAC30SC_RS00115	COG0110	maltose O-acetyltransferase activity
LAC30SC_RS00125	COG4690	dipeptidase activity
LAC30SC_RS00145	COG2096	Adenosyltransferase
LAC30SC_RS00160	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LAC30SC_RS00165	COG0628	permease
LAC30SC_RS00190	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LAC30SC_RS00205	COG1011	Hydrolase
LAC30SC_RS00215	COG0561	phosphatase activity
LAC30SC_RS00225	COG0406	alpha-ribazole phosphatase activity
LAC30SC_RS00230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LAC30SC_RS00235	COG0708	Exodeoxyribonuclease III
LAC30SC_RS00245	COG1061	Type III restriction enzyme res subunit
LAC30SC_RS00260	COG0242	peptide deformylase activity
LAC30SC_RS00295	COG0583	DNA-binding transcription factor activity
LAC30SC_RS00300	COG1053	succinate dehydrogenase
LAC30SC_RS00300	COG3976	FMN-binding domain protein
LAC30SC_RS00405	COG0745	RESPONSE REGULATOR receiver
LAC30SC_RS00410	COG5002	protein histidine kinase activity
LAC30SC_RS00425	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LAC30SC_RS00430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LAC30SC_RS00435	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LAC30SC_RS00450	COG0110	maltose O-acetyltransferase activity
LAC30SC_RS00455	COG2267	carboxylic ester hydrolase activity
LAC30SC_RS00465	COG1122	ATPase activity
LAC30SC_RS00475	COG0501	Belongs to the peptidase M48B family
LAC30SC_RS00480	COG1704	LemA family
LAC30SC_RS00485	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LAC30SC_RS00495	COG0584	glycerophosphoryl diester phosphodiesterase
LAC30SC_RS00505	COG1215	transferase activity, transferring glycosyl groups
LAC30SC_RS00510	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
LAC30SC_RS00535	COG1126	abc transporter atp-binding protein
LAC30SC_RS00540	COG0765	amino acid transport
LAC30SC_RS00545	COG2094	Belongs to the DNA glycosylase MPG family
LAC30SC_RS00550	COG3189	MarR family transcriptional regulator
LAC30SC_RS00555	COG0861	Integral membrane protein TerC family
LAC30SC_RS00565	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LAC30SC_RS00575	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LAC30SC_RS00595	COG0328	RNA-DNA hybrid ribonuclease activity
LAC30SC_RS00605	COG1216	Glycosyl transferase, family 2
LAC30SC_RS00640	COG0765	amino acid transport
LAC30SC_RS00645	COG1126	abc transporter atp-binding protein
LAC30SC_RS00655	COG1181	Belongs to the D-alanine--D-alanine ligase family
LAC30SC_RS00675	COG2755	lipolytic protein G-D-S-L family
LAC30SC_RS00675	COG0657	acetylesterase activity
LAC30SC_RS00700	COG2365	Tyrosine phosphatase family
LAC30SC_RS00705	COG0589	response to stress
LAC30SC_RS00715	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LAC30SC_RS00730	COG0519	Catalyzes the synthesis of GMP from XMP
LAC30SC_RS00745	COG0367	asparagine synthase
LAC30SC_RS00770	COG1328	CTP reductase activity
LAC30SC_RS00775	COG0602	queuosine metabolic process
LAC30SC_RS00780	COG2151	metal-sulfur cluster biosynthetic enzyme
LAC30SC_RS00790	COG2814	Major facilitator Superfamily
LAC30SC_RS00795	COG3590	peptidase
LAC30SC_RS00820	COG3158	transport of potassium into the cell
LAC30SC_RS00865	COG1705	Flagellar rod assembly protein muramidase FlgJ
LAC30SC_RS00875	COG0475	glutathione-regulated potassium exporter activity
LAC30SC_RS00875	COG0569	domain protein
LAC30SC_RS00880	COG0673	inositol 2-dehydrogenase activity
LAC30SC_RS00895	COG0588	phosphoglycerate mutase activity
LAC30SC_RS00900	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
LAC30SC_RS00910	COG1316	TRANSCRIPTIONal
LAC30SC_RS00915	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LAC30SC_RS00920	COG1368	sulfuric ester hydrolase activity
LAC30SC_RS00930	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LAC30SC_RS00950	COG3579	cysteine-type endopeptidase activity
LAC30SC_RS00955	COG1418	mRNA catabolic process
LAC30SC_RS00960	COG4166	transmembrane transport
LAC30SC_RS00965	COG4166	transmembrane transport
LAC30SC_RS00970	COG0516	GMP reductase activity
LAC30SC_RS00970	COG0517	IMP dehydrogenase activity
LAC30SC_RS00975	COG0601	transmembrane transport
LAC30SC_RS00980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LAC30SC_RS00985	COG0444	Belongs to the ABC transporter superfamily
LAC30SC_RS00990	COG4608	Belongs to the ABC transporter superfamily
LAC30SC_RS00995	COG0675	Transposase, IS605 OrfB family
LAC30SC_RS01005	COG3579	cysteine-type endopeptidase activity
LAC30SC_RS01015	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LAC30SC_RS01040	COG2131	deaminase
LAC30SC_RS01050	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LAC30SC_RS01055	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LAC30SC_RS01055	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LAC30SC_RS01060	COG0084	hydrolase, TatD family'
LAC30SC_RS01070	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LAC30SC_RS01075	COG4466	Protein conserved in bacteria
LAC30SC_RS01080	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LAC30SC_RS01085	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LAC30SC_RS01100	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LAC30SC_RS01105	COG2723	6-phospho-beta-galactosidase activity
LAC30SC_RS01115	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LAC30SC_RS01130	COG1078	dGTPase activity
LAC30SC_RS01140	COG3343	RNA polymerase activity
LAC30SC_RS01145	COG0504	CTP synthase activity
LAC30SC_RS01150	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LAC30SC_RS01155	COG4690	dipeptidase activity
LAC30SC_RS01175	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LAC30SC_RS01185	COG1396	sequence-specific DNA binding
LAC30SC_RS01190	COG0519	Catalyzes the synthesis of GMP from XMP
LAC30SC_RS01205	COG2326	polyphosphate kinase activity
LAC30SC_RS01220	COG0456	acetyltransferase
LAC30SC_RS01230	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LAC30SC_RS01235	COG0531	amino acid
LAC30SC_RS01240	COG0561	phosphatase activity
LAC30SC_RS01245	COG0366	Alpha amylase catalytic
LAC30SC_RS01250	COG0254	rRNA binding
LAC30SC_RS01260	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LAC30SC_RS01270	COG0736	holo-[acyl-carrier-protein] synthase activity
LAC30SC_RS01275	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LAC30SC_RS01285	COG0039	L-malate dehydrogenase activity
LAC30SC_RS01290	COG0193	aminoacyl-tRNA hydrolase activity
LAC30SC_RS01295	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LAC30SC_RS01300	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LAC30SC_RS01315	COG0037	tRNA processing
LAC30SC_RS01325	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LAC30SC_RS01330	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LAC30SC_RS01335	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LAC30SC_RS01355	COG1674	ftsk spoiiie
LAC30SC_RS01405	COG1956	GAF domain-containing protein
LAC30SC_RS01410	COG0542	response to heat
LAC30SC_RS01415	COG0085	RNA polymerase activity
LAC30SC_RS01420	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LAC30SC_RS01430	COG2801	Transposase and inactivated derivatives
LAC30SC_RS01435	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LAC30SC_RS01440	COG0049	tRNA binding
LAC30SC_RS01445	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LAC30SC_RS01450	COG0051	transcription antitermination factor activity, RNA binding
LAC30SC_RS01455	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LAC30SC_RS01460	COG0088	Forms part of the polypeptide exit tunnel
LAC30SC_RS01465	COG0089	rRNA binding
LAC30SC_RS01470	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LAC30SC_RS01480	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LAC30SC_RS01485	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LAC30SC_RS01490	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LAC30SC_RS01495	COG0255	Belongs to the universal ribosomal protein uL29 family
LAC30SC_RS01500	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LAC30SC_RS01505	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LAC30SC_RS01510	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LAC30SC_RS01515	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LAC30SC_RS01525	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LAC30SC_RS01530	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LAC30SC_RS01535	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LAC30SC_RS01540	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LAC30SC_RS01545	COG1841	ribosomal large subunit assembly
LAC30SC_RS01550	COG0200	Binds to the 23S rRNA
LAC30SC_RS01560	COG0563	adenylate kinase activity
LAC30SC_RS01565	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LAC30SC_RS01575	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LAC30SC_RS01580	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LAC30SC_RS01585	COG0202	RNA polymerase activity
LAC30SC_RS01590	COG0203	ribosomal protein L17
LAC30SC_RS01595	COG1122	ATPase activity
LAC30SC_RS01600	COG1122	ATPase activity
LAC30SC_RS01605	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LAC30SC_RS01610	COG0101	tRNA pseudouridine synthase activity
LAC30SC_RS01620	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LAC30SC_RS01630	COG0582	viral genome integration into host DNA
LAC30SC_RS01665	COG1002	Type II restriction enzyme, methylase subunits
LAC30SC_RS01675	COG4619	ABC transporter
LAC30SC_RS01680	COG0390	transport system, permease component
LAC30SC_RS01705	COG1230	cation diffusion facilitator family transporter
LAC30SC_RS01715	COG0588	phosphoglycerate mutase activity
LAC30SC_RS01735	COG0756	dUTP diphosphatase activity
LAC30SC_RS01745	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LAC30SC_RS01750	COG0215	cysteine-tRNA ligase activity
LAC30SC_RS01755	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
LAC30SC_RS01760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LAC30SC_RS01780	COG1070	Carbohydrate kinase
LAC30SC_RS01785	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LAC30SC_RS01795	COG0250	Participates in transcription elongation, termination and antitermination
LAC30SC_RS01800	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LAC30SC_RS01805	COG0081	regulation of translation
LAC30SC_RS01820	COG0573	inorganic phosphate transmembrane transporter activity
LAC30SC_RS01830	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LAC30SC_RS01835	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LAC30SC_RS01840	COG0704	Plays a role in the regulation of phosphate uptake
LAC30SC_RS01845	COG0679	Auxin Efflux Carrier
LAC30SC_RS01855	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LAC30SC_RS01860	COG0222	ribosome binding
LAC30SC_RS01870	COG2813	Specifically methylates the guanine in position
LAC30SC_RS01880	COG0590	tRNA wobble adenosine to inosine editing
LAC30SC_RS01885	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LAC30SC_RS01890	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LAC30SC_RS01895	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LAC30SC_RS01905	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LAC30SC_RS01910	COG3870	Protein conserved in bacteria
LAC30SC_RS01915	COG0470	DNA polymerase III
LAC30SC_RS01935	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
LAC30SC_RS01940	COG1214	PFAM Peptidase M22, glycoprotease
LAC30SC_RS01950	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LAC30SC_RS01965	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LAC30SC_RS01975	COG0488	(ABC) transporter
LAC30SC_RS01980	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
LAC30SC_RS01990	COG1621	beta-fructofuranosidase activity
LAC30SC_RS01995	COG1263	PTS System
LAC30SC_RS01995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LAC30SC_RS01995	COG2190	(PTS) system
LAC30SC_RS02045	COG1472	Belongs to the glycosyl hydrolase 3 family
LAC30SC_RS02055	COG1285	pathogenesis
LAC30SC_RS02070	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LAC30SC_RS02075	COG0459	protein refolding
LAC30SC_RS02080	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LAC30SC_RS02085	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LAC30SC_RS02090	COG0632	four-way junction helicase activity
LAC30SC_RS02095	COG2255	four-way junction helicase activity
LAC30SC_RS02105	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LAC30SC_RS02110	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LAC30SC_RS02115	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LAC30SC_RS02120	COG0513	Belongs to the DEAD box helicase family
LAC30SC_RS02125	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LAC30SC_RS02130	COG4472	Bacterial protein of unknown function (DUF965)
LAC30SC_RS02135	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LAC30SC_RS02140	COG3906	Belongs to the UPF0473 family
LAC30SC_RS02145	COG1193	negative regulation of DNA recombination
LAC30SC_RS02150	COG3118	belongs to the thioredoxin family
LAC30SC_RS02160	COG0431	NADPH-dependent FMN reductase
LAC30SC_RS02175	COG1970	mechanosensitive ion channel activity
LAC30SC_RS02180	COG1719	4-vinyl reductase, 4VR
LAC30SC_RS02185	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LAC30SC_RS02190	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LAC30SC_RS02205	COG0668	transmembrane transport
LAC30SC_RS02220	COG0006	proline dipeptidase activity
LAC30SC_RS02230	COG0584	glycerophosphoryl diester phosphodiesterase
LAC30SC_RS02240	COG0737	Belongs to the 5'-nucleotidase family
LAC30SC_RS02250	COG0647	UMP catabolic process
LAC30SC_RS02260	COG0586	Pfam SNARE associated Golgi protein
LAC30SC_RS02265	COG0492	ferredoxin-NADP+ reductase activity
LAC30SC_RS02440	COG0438	transferase activity, transferring glycosyl groups
LAC30SC_RS02445	COG0438	transferase activity, transferring glycosyl groups
LAC30SC_RS02455	COG1368	sulfuric ester hydrolase activity
LAC30SC_RS02460	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LAC30SC_RS02465	COG0557	exoribonuclease II activity
LAC30SC_RS02470	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LAC30SC_RS02505	COG3715	PTS system
LAC30SC_RS02510	COG3716	PTS system mannose fructose sorbose family IID component
LAC30SC_RS02525	COG2801	Transposase and inactivated derivatives
LAC30SC_RS02530	COG0583	DNA-binding transcription factor activity
LAC30SC_RS02540	COG1113	amino acid transport
LAC30SC_RS02545	COG1012	belongs to the aldehyde dehydrogenase family
LAC30SC_RS02545	COG1454	alcohol dehydrogenase
LAC30SC_RS02550	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LAC30SC_RS02560	COG2213	PTS system mannitol-specific
LAC30SC_RS02565	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LAC30SC_RS02575	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LAC30SC_RS02595	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LAC30SC_RS02610	COG1111	helicase
LAC30SC_RS02610	COG1205	dead DEAH box helicase
LAC30SC_RS02620	COG0778	Nitroreductase
LAC30SC_RS02640	COG2801	Transposase and inactivated derivatives
LAC30SC_RS02650	COG1523	belongs to the glycosyl hydrolase 13 family
LAC30SC_RS02685	COG0463	Glycosyl transferase, family 2
LAC30SC_RS02715	COG0588	phosphoglycerate mutase activity
LAC30SC_RS02730	COG0584	glycerophosphoryl diester phosphodiesterase
LAC30SC_RS02750	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LAC30SC_RS02795	COG0148	phosphopyruvate hydratase activity
LAC30SC_RS02805	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LAC30SC_RS02835	COG2188	Transcriptional regulator
LAC30SC_RS02845	COG0798	PFAM Bile acid sodium symporter
LAC30SC_RS02850	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LAC30SC_RS02860	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
LAC30SC_RS02870	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LAC30SC_RS02885	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LAC30SC_RS02910	COG1705	Flagellar rod assembly protein muramidase FlgJ
LAC30SC_RS02920	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LAC30SC_RS02925	COG4851	CamS sex pheromone cAM373 precursor
LAC30SC_RS02930	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LAC30SC_RS02935	COG0154	amidase activity
LAC30SC_RS02940	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LAC30SC_RS02945	COG1597	lipid kinase activity
LAC30SC_RS02955	COG0670	Belongs to the BI1 family
LAC30SC_RS02965	COG1757	Na H antiporter
LAC30SC_RS02970	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LAC30SC_RS03000	COG0477	Major facilitator Superfamily
LAC30SC_RS03010	COG4716	Myosin-crossreactive antigen
LAC30SC_RS03030	COG0656	L-ascorbic acid biosynthetic process
LAC30SC_RS03050	COG2814	Major facilitator Superfamily
LAC30SC_RS03055	COG2814	Major facilitator Superfamily
LAC30SC_RS03065	COG0488	(ABC) transporter
LAC30SC_RS03075	COG4989	oxidoreductase activity
LAC30SC_RS03085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LAC30SC_RS03095	COG1132	(ABC) transporter
LAC30SC_RS03100	COG1132	(ABC) transporter
LAC30SC_RS03115	COG0572	uridine kinase
LAC30SC_RS03125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LAC30SC_RS03130	COG0765	amino acid transport
LAC30SC_RS03135	COG0765	amino acid transport
LAC30SC_RS03165	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LAC30SC_RS03170	COG3158	transport of potassium into the cell
LAC30SC_RS03180	COG2188	Transcriptional regulator
LAC30SC_RS03185	COG0561	phosphatase activity
LAC30SC_RS03195	COG1349	DNA-binding transcription factor activity
LAC30SC_RS03200	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
LAC30SC_RS03215	COG1263	PTS System
LAC30SC_RS03215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LAC30SC_RS03230	COG2190	(PTS) system
LAC30SC_RS03230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LAC30SC_RS03230	COG1263	PTS System
LAC30SC_RS03245	COG1253	flavin adenine dinucleotide binding
LAC30SC_RS03255	COG0531	amino acid
LAC30SC_RS03270	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LAC30SC_RS03280	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LAC30SC_RS03285	COG2801	Transposase and inactivated derivatives
LAC30SC_RS03295	COG0716	FMN binding
LAC30SC_RS03300	COG0024	Methionine aminopeptidase
LAC30SC_RS03315	COG0183	Belongs to the thiolase family
LAC30SC_RS03325	COG3425	synthase
LAC30SC_RS03340	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LAC30SC_RS03365	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LAC30SC_RS03375	COG0542	response to heat
LAC30SC_RS03385	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LAC30SC_RS03395	COG1393	Belongs to the ArsC family
LAC30SC_RS03420	COG2357	RelA SpoT domain protein
LAC30SC_RS03425	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LAC30SC_RS03430	COG0564	pseudouridine synthase activity
LAC30SC_RS03445	COG2706	6-phosphogluconolactonase activity
LAC30SC_RS03450	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LAC30SC_RS03460	COG0628	permease
LAC30SC_RS03475	COG1674	ftsk spoiiie
LAC30SC_RS03485	COG0612	Peptidase, M16
LAC30SC_RS03495	COG1426	Protein conserved in bacteria
LAC30SC_RS03500	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LAC30SC_RS03505	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LAC30SC_RS03510	COG1418	mRNA catabolic process
LAC30SC_RS03515	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LAC30SC_RS03520	COG1739	Uncharacterized protein family UPF0029
LAC30SC_RS03525	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
LAC30SC_RS03540	COG0653	protein targeting
LAC30SC_RS03545	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LAC30SC_RS03555	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LAC30SC_RS03560	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LAC30SC_RS03565	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LAC30SC_RS03570	COG0492	ferredoxin-NADP+ reductase activity
LAC30SC_RS03575	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LAC30SC_RS03580	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LAC30SC_RS03590	COG0297	glycogen (starch) synthase activity
LAC30SC_RS03595	COG0058	SHG alpha-glucan phosphorylase activity
LAC30SC_RS03600	COG3103	Sh3 type 3 domain protein
LAC30SC_RS03600	COG0366	Alpha amylase catalytic
LAC30SC_RS03605	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LAC30SC_RS03610	COG0556	nucleotide-excision repair
LAC30SC_RS03615	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LAC30SC_RS03625	COG1660	Displays ATPase and GTPase activities
LAC30SC_RS03630	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LAC30SC_RS03635	COG1481	regulation of sporulation
LAC30SC_RS03640	COG0740	serine-type endopeptidase activity
LAC30SC_RS03650	COG0531	amino acid
LAC30SC_RS03665	COG2390	Transcriptional regulator
LAC30SC_RS03675	COG0126	phosphoglycerate kinase activity
LAC30SC_RS03680	COG0149	triose-phosphate isomerase activity
LAC30SC_RS03700	COG0561	phosphatase activity
LAC30SC_RS03705	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LAC30SC_RS03710	COG0280	phosphate acetyltransferase
LAC30SC_RS03715	COG0802	atpase or kinase
LAC30SC_RS03725	COG0675	Transposase, IS605 OrfB family
LAC30SC_RS03735	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LAC30SC_RS03740	COG3842	ATPase activity
LAC30SC_RS03745	COG1176	ABC-type spermidine putrescine transport system, permease component I
LAC30SC_RS03750	COG1175	transmembrane transport
LAC30SC_RS03765	COG4856	YbbR-like protein
LAC30SC_RS03770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LAC30SC_RS03775	COG0561	phosphatase activity
LAC30SC_RS03780	COG0561	phosphatase activity
LAC30SC_RS03790	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LAC30SC_RS03795	COG1929	Belongs to the glycerate kinase type-1 family
LAC30SC_RS03820	COG0531	amino acid
LAC30SC_RS03830	COG0217	transcriptional regulatory protein
LAC30SC_RS03835	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LAC30SC_RS03865	COG0827	DNA restriction-modification system
LAC30SC_RS03870	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LAC30SC_RS03880	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LAC30SC_RS03885	COG1482	cell wall glycoprotein biosynthetic process
LAC30SC_RS03895	COG0745	RESPONSE REGULATOR receiver
LAC30SC_RS03900	COG5002	protein histidine kinase activity
LAC30SC_RS03900	COG3850	Histidine kinase
LAC30SC_RS03905	COG1368	sulfuric ester hydrolase activity
LAC30SC_RS03915	COG0166	Belongs to the GPI family
LAC30SC_RS03920	COG0477	Major facilitator Superfamily
LAC30SC_RS03925	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LAC30SC_RS03940	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LAC30SC_RS03945	COG1435	thymidine kinase activity
LAC30SC_RS03950	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LAC30SC_RS03955	COG2890	protein-(glutamine-N5) methyltransferase activity
LAC30SC_RS03960	COG0009	L-threonylcarbamoyladenylate synthase
LAC30SC_RS03965	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LAC30SC_RS03970	COG0356	it plays a direct role in the translocation of protons across the membrane
LAC30SC_RS03975	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LAC30SC_RS03980	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LAC30SC_RS03985	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LAC30SC_RS03990	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LAC30SC_RS03995	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LAC30SC_RS04000	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LAC30SC_RS04005	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LAC30SC_RS04010	COG4836	Membrane
LAC30SC_RS04015	COG1077	Cell shape determining protein MreB Mrl
LAC30SC_RS04025	COG0772	Belongs to the SEDS family
LAC30SC_RS04030	COG1472	Belongs to the glycosyl hydrolase 3 family
LAC30SC_RS04050	COG5506	Protein of unknown function (DUF1694)
LAC30SC_RS04055	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LAC30SC_RS04060	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
LAC30SC_RS04065	COG1104	cysteine desulfurase activity
LAC30SC_RS04070	COG0301	tRNA thio-modification
LAC30SC_RS04085	COG1187	pseudouridine synthase activity
LAC30SC_RS04095	COG1053	succinate dehydrogenase
LAC30SC_RS04095	COG3976	FMN-binding domain protein
LAC30SC_RS04100	COG0525	valine-tRNA ligase activity
LAC30SC_RS04110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LAC30SC_RS04115	COG2003	Belongs to the UPF0758 family
LAC30SC_RS04120	COG1077	Cell shape determining protein MreB Mrl
LAC30SC_RS04125	COG1792	Involved in formation and maintenance of cell shape
LAC30SC_RS04140	COG2001	Belongs to the MraZ family
LAC30SC_RS04145	COG0275	rRNA processing
LAC30SC_RS04155	COG0768	penicillin binding
LAC30SC_RS04160	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LAC30SC_RS04165	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LAC30SC_RS04170	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LAC30SC_RS04175	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LAC30SC_RS04185	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LAC30SC_RS04190	COG1799	cell septum assembly
LAC30SC_RS04195	COG0762	integral membrane protein
LAC30SC_RS04205	COG3599	regulation of cell shape
LAC30SC_RS04210	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LAC30SC_RS04215	COG1278	Cold shock
LAC30SC_RS04220	COG0494	nUDIX hydrolase
LAC30SC_RS04230	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LAC30SC_RS04245	COG0482	sulfurtransferase activity
LAC30SC_RS04250	COG0406	alpha-ribazole phosphatase activity
LAC30SC_RS04260	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LAC30SC_RS04280	COG1597	lipid kinase activity
LAC30SC_RS04290	COG5503	Protein of unknown function (DUF1447)
LAC30SC_RS04295	COG0242	peptide deformylase activity
LAC30SC_RS04300	COG1217	gtp-binding protein TYPA
LAC30SC_RS04305	COG0772	Belongs to the SEDS family
LAC30SC_RS04310	COG4471	UPF0298 protein
LAC30SC_RS04315	COG0742	ribosomal rna small subunit methyltransferase
LAC30SC_RS04320	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LAC30SC_RS04325	COG3480	Lon protease (S16) C-terminal proteolytic domain
LAC30SC_RS04330	COG1555	photosystem II stabilization
LAC30SC_RS04335	COG0658	competence protein
LAC30SC_RS04335	COG2333	competence protein COMEC
LAC30SC_RS04340	COG1466	dna polymerase III delta subunit
LAC30SC_RS04345	COG0268	Binds directly to 16S ribosomal RNA
LAC30SC_RS04350	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LAC30SC_RS04365	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LAC30SC_RS04370	COG0544	peptidyl-prolyl cis-trans isomerase activity
LAC30SC_RS04375	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LAC30SC_RS04380	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LAC30SC_RS04395	COG0527	aspartate kinase activity
LAC30SC_RS04405	COG2171	N-acyltransferase activity
LAC30SC_RS04410	COG1473	amidohydrolase
LAC30SC_RS04415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LAC30SC_RS04420	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LAC30SC_RS04425	COG0436	Aminotransferase
LAC30SC_RS04430	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LAC30SC_RS04435	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LAC30SC_RS04460	COG1957	nucleoside hydrolase
LAC30SC_RS04480	COG2261	transglycosylase associated protein
LAC30SC_RS04485	COG2723	6-phospho-beta-galactosidase activity
LAC30SC_RS04490	COG2188	Transcriptional regulator
LAC30SC_RS04495	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LAC30SC_RS04500	COG1447	Phosphotransferase system cellobiose-specific component IIA
LAC30SC_RS04510	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LAC30SC_RS04515	COG4372	Transposase
LAC30SC_RS04535	COG2723	6-phospho-beta-galactosidase activity
LAC30SC_RS04540	COG2188	Transcriptional regulator
LAC30SC_RS04550	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LAC30SC_RS04555	COG2723	6-phospho-beta-galactosidase activity
LAC30SC_RS04585	COG0148	phosphopyruvate hydratase activity
LAC30SC_RS04600	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
LAC30SC_RS04610	COG1113	amino acid transport
LAC30SC_RS04615	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LAC30SC_RS04625	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LAC30SC_RS04640	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LAC30SC_RS04645	COG2011	ABC-type metal ion transport system permease component
LAC30SC_RS04650	COG0114	fumarate hydratase activity
LAC30SC_RS04655	COG1053	succinate dehydrogenase
LAC30SC_RS04660	COG0039	L-malate dehydrogenase activity
LAC30SC_RS04665	COG3579	cysteine-type endopeptidase activity
LAC30SC_RS04675	COG2267	carboxylic ester hydrolase activity
LAC30SC_RS04680	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
LAC30SC_RS04695	COG2707	UPF0756 membrane protein
LAC30SC_RS04705	COG1122	ATPase activity
LAC30SC_RS04710	COG4720	Psort location CytoplasmicMembrane, score
LAC30SC_RS04750	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LAC30SC_RS04755	COG2264	protein methyltransferase activity
LAC30SC_RS04765	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LAC30SC_RS04770	COG1490	D-aminoacyl-tRNA deacylase activity
LAC30SC_RS04775	COG0124	histidyl-tRNA synthetase
LAC30SC_RS04780	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LAC30SC_RS04785	COG2801	Transposase and inactivated derivatives
LAC30SC_RS04790	COG0436	Aminotransferase
LAC30SC_RS04800	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LAC30SC_RS04810	COG0561	phosphatase activity
LAC30SC_RS04820	COG0531	amino acid
LAC30SC_RS04825	COG0586	Pfam SNARE associated Golgi protein
LAC30SC_RS04830	COG0322	excinuclease ABC activity
LAC30SC_RS04835	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LAC30SC_RS04840	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LAC30SC_RS04840	COG2755	lipolytic protein G-D-S-L family
LAC30SC_RS04845	COG1234	tRNA 3'-trailer cleavage
LAC30SC_RS04850	COG0300	oxidoreductase activity
LAC30SC_RS04860	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LAC30SC_RS04865	COG0737	Belongs to the 5'-nucleotidase family
LAC30SC_RS04875	COG0587	DNA-directed DNA polymerase activity
LAC30SC_RS04880	COG0205	6-phosphofructokinase activity
LAC30SC_RS04890	COG2996	Protein conserved in bacteria
LAC30SC_RS04900	COG0456	acetyltransferase
LAC30SC_RS04905	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LAC30SC_RS04915	COG1187	pseudouridine synthase activity
LAC30SC_RS04920	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
LAC30SC_RS04930	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LAC30SC_RS04935	COG0539	negative regulation of cytoplasmic translation
LAC30SC_RS04940	COG1160	GTP binding
LAC30SC_RS04960	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LAC30SC_RS04965	COG0617	tRNA 3'-terminal CCA addition
LAC30SC_RS04975	COG1272	protein, Hemolysin III
LAC30SC_RS04980	COG1307	EDD domain protein, DegV family
LAC30SC_RS04985	COG4479	Belongs to the UPF0346 family
LAC30SC_RS04990	COG0025	NhaP-type Na H and K H
LAC30SC_RS04995	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LAC30SC_RS05000	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LAC30SC_RS05005	COG0758	DNA mediated transformation
LAC30SC_RS05010	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LAC30SC_RS05015	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
LAC30SC_RS05030	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LAC30SC_RS05055	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LAC30SC_RS05060	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LAC30SC_RS05085	COG0531	amino acid
LAC30SC_RS05090	COG1982	Orn Lys Arg decarboxylase major
LAC30SC_RS05095	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
LAC30SC_RS05100	COG0569	domain protein
LAC30SC_RS05105	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LAC30SC_RS05110	COG0514	ATP-dependent DNA helicase (RecQ)
LAC30SC_RS05120	COG2040	homocysteine
LAC30SC_RS05155	COG0366	Alpha amylase catalytic
LAC30SC_RS05160	COG0531	amino acid
LAC30SC_RS05190	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LAC30SC_RS05195	COG0778	Nitroreductase
LAC30SC_RS05225	COG2267	carboxylic ester hydrolase activity
LAC30SC_RS05255	COG1199	ATP-dependent helicase activity
LAC30SC_RS05305	COG1132	(ABC) transporter
LAC30SC_RS05330	COG1193	negative regulation of DNA recombination
LAC30SC_RS05335	COG4372	Transposase
LAC30SC_RS05440	COG2801	Transposase and inactivated derivatives
LAC30SC_RS05460	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LAC30SC_RS05465	COG1854	S-ribosylhomocysteine lyase activity
LAC30SC_RS05470	COG0561	phosphatase activity
LAC30SC_RS05480	COG2814	Major facilitator Superfamily
LAC30SC_RS05485	COG1288	antiporter activity
LAC30SC_RS05535	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LAC30SC_RS05545	COG0248	Ppx GppA phosphatase
LAC30SC_RS05560	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LAC30SC_RS05570	COG0783	Belongs to the Dps family
LAC30SC_RS05575	COG0656	L-ascorbic acid biosynthetic process
LAC30SC_RS05600	COG0431	NADPH-dependent FMN reductase
LAC30SC_RS05600	COG1053	succinate dehydrogenase
LAC30SC_RS05600	COG3976	FMN-binding domain protein
LAC30SC_RS05645	COG0765	amino acid transport
LAC30SC_RS05650	COG0765	amino acid transport
LAC30SC_RS05655	COG1126	abc transporter atp-binding protein
LAC30SC_RS05665	COG0588	phosphoglycerate mutase activity
LAC30SC_RS05710	COG0110	maltose O-acetyltransferase activity
LAC30SC_RS05715	COG0673	inositol 2-dehydrogenase activity
LAC30SC_RS05725	COG1737	Transcriptional regulator
LAC30SC_RS05745	COG0588	phosphoglycerate mutase activity
LAC30SC_RS05770	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
LAC30SC_RS05775	COG1846	Transcriptional regulator
LAC30SC_RS05785	COG1376	ErfK ybiS ycfS ynhG family protein
LAC30SC_RS05800	COG0531	amino acid
LAC30SC_RS05805	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LAC30SC_RS05810	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LAC30SC_RS05815	COG1114	Component of the transport system for branched-chain amino acids
LAC30SC_RS05825	COG1063	alcohol dehydrogenase
LAC30SC_RS05845	COG2855	membrane
LAC30SC_RS05855	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LAC30SC_RS05860	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LAC30SC_RS05865	COG0187	DNA topoisomerase II activity
LAC30SC_RS05875	COG0583	DNA-binding transcription factor activity
LAC30SC_RS05880	COG1227	inorganic diphosphatase activity
LAC30SC_RS05895	COG1396	sequence-specific DNA binding
LAC30SC_RS05975	COG2184	nucleotidyltransferase activity
LAC30SC_RS05995	COG1132	(ABC) transporter
LAC30SC_RS06045	COG4974	Belongs to the 'phage' integrase family
LAC30SC_RS06050	COG1307	EDD domain protein, DegV family
LAC30SC_RS06065	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LAC30SC_RS06070	COG0505	Belongs to the CarA family
LAC30SC_RS06075	COG0564	pseudouridine synthase activity
LAC30SC_RS06085	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LAC30SC_RS06100	COG0116	Belongs to the methyltransferase superfamily
LAC30SC_RS06105	COG3599	regulation of cell shape
LAC30SC_RS06110	COG4474	Belongs to the UPF0398 family
LAC30SC_RS06115	COG3331	DNA recombination
LAC30SC_RS06120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LAC30SC_RS06125	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LAC30SC_RS06135	COG0017	Asparaginyl-tRNA synthetase
LAC30SC_RS06145	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LAC30SC_RS06145	COG1199	ATP-dependent helicase activity
LAC30SC_RS06150	COG1074	ATP-dependent DNA helicase activity
LAC30SC_RS06155	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
LAC30SC_RS06160	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LAC30SC_RS06175	COG1304	FMN binding
LAC30SC_RS06185	COG0561	phosphatase activity
LAC30SC_RS06190	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LAC30SC_RS06190	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
LAC30SC_RS06235	COG1131	(ABC) transporter
LAC30SC_RS06240	COG1725	Transcriptional regulator
LAC30SC_RS06245	COG2195	Cleaves the N-terminal amino acid of tripeptides
LAC30SC_RS06250	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LAC30SC_RS06255	COG2384	SAM-dependent methyltransferase
LAC30SC_RS06260	COG2816	NAD+ diphosphatase activity
LAC30SC_RS06270	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LAC30SC_RS06275	COG0358	DNA primase activity
LAC30SC_RS06280	COG0751	glycine-tRNA ligase activity
LAC30SC_RS06285	COG0752	glycyl-tRNA synthetase alpha subunit
LAC30SC_RS06290	COG1381	Involved in DNA repair and RecF pathway recombination
LAC30SC_RS06295	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LAC30SC_RS06300	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LAC30SC_RS06305	COG1702	phosphate starvation-inducible protein PhoH
LAC30SC_RS06320	COG2151	metal-sulfur cluster biosynthetic enzyme
LAC30SC_RS06325	COG0719	Fe-S assembly protein
LAC30SC_RS06330	COG0822	iron-sulfur transferase activity
LAC30SC_RS06335	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LAC30SC_RS06340	COG0719	Fe-S assembly protein
LAC30SC_RS06350	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LAC30SC_RS06355	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LAC30SC_RS06365	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LAC30SC_RS06480	COG1783	phage Terminase large subunit
LAC30SC_RS06485	COG5484	DNA packaging
LAC30SC_RS06485	COG3728	DNA packaging
LAC30SC_RS06580	COG3617	BRO family, N-terminal domain
LAC30SC_RS06590	COG1396	sequence-specific DNA binding
LAC30SC_RS06625	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LAC30SC_RS06650	COG2801	Transposase and inactivated derivatives
LAC30SC_RS06660	COG0083	homoserine kinase activity
LAC30SC_RS06680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LAC30SC_RS06720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LAC30SC_RS06725	COG1114	Component of the transport system for branched-chain amino acids
LAC30SC_RS06765	COG2235	arginine
LAC30SC_RS06770	COG0583	DNA-binding transcription factor activity
LAC30SC_RS06795	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LAC30SC_RS06815	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LAC30SC_RS06820	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LAC30SC_RS06820	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LAC30SC_RS06825	COG3764	Sortase (surface protein transpeptidase)
LAC30SC_RS06830	COG0481	GTPase activity
LAC30SC_RS06835	COG0484	heat shock protein binding
LAC30SC_RS06840	COG0443	Heat shock 70 kDa protein
LAC30SC_RS06845	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LAC30SC_RS06850	COG1420	regulation of RNA biosynthetic process
LAC30SC_RS06855	COG0488	(ABC) transporter
LAC30SC_RS06860	COG0196	riboflavin kinase activity
LAC30SC_RS06865	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LAC30SC_RS06870	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LAC30SC_RS06875	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LAC30SC_RS06885	COG2740	Nucleic-acid-binding protein implicated in transcription termination
LAC30SC_RS06890	COG0195	Participates in both transcription termination and antitermination
LAC30SC_RS06895	COG0779	Required for maturation of 30S ribosomal subunits
LAC30SC_RS06905	COG0442	prolyl-tRNA aminoacylation
LAC30SC_RS06910	COG0750	zinc metalloprotease
LAC30SC_RS06915	COG4589	Belongs to the CDS family
LAC30SC_RS06920	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LAC30SC_RS06925	COG0233	cytoplasmic translational termination
LAC30SC_RS06930	COG0528	UMP kinase activity
LAC30SC_RS06940	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LAC30SC_RS06945	COG0052	Belongs to the universal ribosomal protein uS2 family
LAC30SC_RS06955	COG0204	Acyl-transferase
LAC30SC_RS06960	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LAC30SC_RS06985	COG4372	Transposase
LAC30SC_RS06990	COG3590	peptidase
LAC30SC_RS06995	COG1132	(ABC) transporter
LAC30SC_RS07000	COG1132	(ABC) transporter
LAC30SC_RS07005	COG3763	UPF0154 protein
LAC30SC_RS07010	COG4224	UPF0291 protein
LAC30SC_RS07015	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LAC30SC_RS07030	COG0335	large ribosomal subunit rRNA binding
LAC30SC_RS07040	COG0675	Transposase, IS605 OrfB family
LAC30SC_RS07050	COG0336	Belongs to the RNA methyltransferase TrmD family
LAC30SC_RS07055	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LAC30SC_RS07060	COG0228	four-way junction DNA binding
LAC30SC_RS07065	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LAC30SC_RS07070	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
LAC30SC_RS07075	COG4975	Glucose uptake
LAC30SC_RS07080	COG0531	amino acid
LAC30SC_RS07095	COG0552	protein localization to endoplasmic reticulum
LAC30SC_RS07100	COG1196	nuclear chromosome segregation
LAC30SC_RS07105	COG0571	ribonuclease III activity
LAC30SC_RS07120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LAC30SC_RS07125	COG0601	transmembrane transport
LAC30SC_RS07130	COG4608	Belongs to the ABC transporter superfamily
LAC30SC_RS07140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LAC30SC_RS07145	COG0416	fatty acid biosynthetic process
LAC30SC_RS07150	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LAC30SC_RS07165	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LAC30SC_RS07180	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LAC30SC_RS07185	COG1162	GTPase activity
LAC30SC_RS07190	COG0515	serine threonine protein kinase
LAC30SC_RS07190	COG2815	serine threonine protein kinase
LAC30SC_RS07200	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LAC30SC_RS07200	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LAC30SC_RS07205	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LAC30SC_RS07210	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LAC30SC_RS07215	COG1758	RNA polymerase activity
LAC30SC_RS07220	COG0194	GDP metabolic process
LAC30SC_RS07235	COG0497	DNA recombination
LAC30SC_RS07240	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
LAC30SC_RS07250	COG1722	exodeoxyribonuclease VII activity
LAC30SC_RS07255	COG1570	exodeoxyribonuclease VII activity
LAC30SC_RS07260	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LAC30SC_RS07270	COG1302	Protein conserved in bacteria
LAC30SC_RS07275	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LAC30SC_RS07280	COG0006	proline dipeptidase activity
LAC30SC_RS07285	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LAC30SC_RS07290	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LAC30SC_RS07300	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LAC30SC_RS07305	COG1942	4-Oxalocrotonate Tautomerase
LAC30SC_RS07310	COG3231	kanamycin kinase activity
LAC30SC_RS07340	COG1132	(ABC) transporter
LAC30SC_RS07345	COG1132	(ABC) transporter
LAC30SC_RS07350	COG0561	phosphatase activity
LAC30SC_RS07380	COG4372	Transposase
LAC30SC_RS07410	COG5002	protein histidine kinase activity
LAC30SC_RS07415	COG0745	RESPONSE REGULATOR receiver
LAC30SC_RS07420	COG0704	Plays a role in the regulation of phosphate uptake
LAC30SC_RS07425	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LAC30SC_RS07430	COG0581	inorganic phosphate transmembrane transporter activity
LAC30SC_RS07435	COG0573	inorganic phosphate transmembrane transporter activity
LAC30SC_RS07440	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LAC30SC_RS07465	COG2936	dipeptidyl-peptidase activity
LAC30SC_RS07480	COG4975	Glucose uptake
LAC30SC_RS07495	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LAC30SC_RS07500	COG0505	Belongs to the CarA family
LAC30SC_RS07505	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LAC30SC_RS07510	COG0540	Belongs to the ATCase OTCase family
LAC30SC_RS07520	COG0167	dihydroorotate dehydrogenase activity
LAC30SC_RS07525	COG0284	orotidine-5'-phosphate decarboxylase activity
LAC30SC_RS07530	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LAC30SC_RS07535	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LAC30SC_RS07565	COG1760	l-serine dehydratase
LAC30SC_RS07570	COG1760	l-serine dehydratase
LAC30SC_RS07575	COG2151	metal-sulfur cluster biosynthetic enzyme
LAC30SC_RS07595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LAC30SC_RS07605	COG0765	amino acid transport
LAC30SC_RS07610	COG0765	amino acid transport
LAC30SC_RS07620	COG2801	Transposase and inactivated derivatives
LAC30SC_RS07650	COG0702	epimerase
LAC30SC_RS07660	COG1715	Restriction endonuclease
LAC30SC_RS07665	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
LAC30SC_RS07680	COG1744	ABC transporter substrate-binding protein PnrA-like
LAC30SC_RS07685	COG3845	ABC transporter
LAC30SC_RS07690	COG4603	Belongs to the binding-protein-dependent transport system permease family
LAC30SC_RS07695	COG1079	Belongs to the binding-protein-dependent transport system permease family
LAC30SC_RS07755	COG2357	RelA SpoT domain protein
LAC30SC_RS07765	COG2814	Major facilitator Superfamily
LAC30SC_RS07775	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LAC30SC_RS07790	COG4372	Transposase
LAC30SC_RS07795	COG0366	Alpha amylase catalytic
LAC30SC_RS07800	COG3345	alpha-galactosidase
LAC30SC_RS07805	COG3842	ATPase activity
LAC30SC_RS07810	COG0395	ABC-type sugar transport system, permease component
LAC30SC_RS07815	COG1175	transmembrane transport
LAC30SC_RS07820	COG1653	transport
LAC30SC_RS07830	COG2017	converts alpha-aldose to the beta-anomer
LAC30SC_RS07835	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
LAC30SC_RS07840	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LAC30SC_RS07855	COG2188	Transcriptional regulator
LAC30SC_RS07860	COG0778	Nitroreductase
LAC30SC_RS07865	COG1874	Beta-galactosidase
LAC30SC_RS07870	COG2211	Major facilitator Superfamily
LAC30SC_RS07870	COG2190	(PTS) system
LAC30SC_RS07875	COG1609	Transcriptional regulator
LAC30SC_RS07880	COG3250	beta-galactosidase activity
LAC30SC_RS07885	COG3250	beta-galactosidase activity
LAC30SC_RS07890	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LAC30SC_RS07895	COG1609	Transcriptional regulator
LAC30SC_RS07900	COG0675	Transposase, IS605 OrfB family
LAC30SC_RS07910	COG2814	Major facilitator Superfamily
LAC30SC_RS07935	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LAC30SC_RS07940	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LAC30SC_RS07955	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LAC30SC_RS07960	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LAC30SC_RS07965	COG0768	penicillin binding
LAC30SC_RS07975	COG2971	BadF BadG BcrA BcrD
LAC30SC_RS07995	COG2195	Cleaves the N-terminal amino acid of tripeptides
LAC30SC_RS08010	COG0072	phenylalanine-tRNA ligase activity
LAC30SC_RS08015	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LAC30SC_RS08020	COG1733	regulation of RNA biosynthetic process
LAC30SC_RS08025	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LAC30SC_RS08030	COG1254	Belongs to the acylphosphatase family
LAC30SC_RS08035	COG0706	membrane insertase activity
LAC30SC_RS08040	COG5002	protein histidine kinase activity
LAC30SC_RS08045	COG0745	RESPONSE REGULATOR receiver
LAC30SC_RS08055	COG1323	Belongs to the UPF0348 family
LAC30SC_RS08060	COG0799	negative regulation of ribosome biogenesis
LAC30SC_RS08065	COG1713	HD superfamily hydrolase involved in NAD metabolism
LAC30SC_RS08070	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LAC30SC_RS08075	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LAC30SC_RS08080	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
LAC30SC_RS08085	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LAC30SC_RS08090	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LAC30SC_RS08095	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LAC30SC_RS08100	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LAC30SC_RS08125	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LAC30SC_RS08130	COG1484	DNA-dependent DNA replication
LAC30SC_RS08140	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LAC30SC_RS08145	COG0237	dephospho-CoA kinase activity
LAC30SC_RS08150	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LAC30SC_RS08155	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LAC30SC_RS08155	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LAC30SC_RS08180	COG0732	type I restriction modification DNA specificity domain
LAC30SC_RS08195	COG0151	Belongs to the GarS family
LAC30SC_RS08200	COG0138	bifunctional purine biosynthesis protein purh
LAC30SC_RS08205	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LAC30SC_RS08210	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LAC30SC_RS08220	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LAC30SC_RS08225	COG0047	phosphoribosylformylglycinamidine synthase activity
LAC30SC_RS08230	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LAC30SC_RS08235	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LAC30SC_RS08245	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LAC30SC_RS08250	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LAC30SC_RS08255	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LAC30SC_RS08290	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LAC30SC_RS08305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LAC30SC_RS08310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LAC30SC_RS08315	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LAC30SC_RS08325	COG1131	(ABC) transporter
LAC30SC_RS08330	COG0537	adenosine 5'-monophosphoramidase activity
LAC30SC_RS08340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LAC30SC_RS08345	COG3481	metal-dependent phosphohydrolase, HD sub domain
LAC30SC_RS08355	COG0420	3'-5' exonuclease activity
LAC30SC_RS08360	COG3679	Belongs to the UPF0342 family
LAC30SC_RS08365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LAC30SC_RS08370	COG0564	pseudouridine synthase activity
LAC30SC_RS08380	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LAC30SC_RS08390	COG0477	Major facilitator Superfamily
LAC30SC_RS08420	COG0018	arginyl-trna synthetase
LAC30SC_RS08425	COG1376	ErfK ybiS ycfS ynhG family protein
LAC30SC_RS08430	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LAC30SC_RS08435	COG1686	Belongs to the peptidase S11 family
LAC30SC_RS08445	COG1983	PspC domain protein
LAC30SC_RS08455	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LAC30SC_RS08460	COG1335	isochorismatase
LAC30SC_RS08475	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LAC30SC_RS08475	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LAC30SC_RS08480	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LAC30SC_RS08485	COG0825	malonyl-CoA metabolic process
LAC30SC_RS08490	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LAC30SC_RS08495	COG0439	Biotin carboxylase
LAC30SC_RS08510	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LAC30SC_RS08515	COG1028	Short-chain dehydrogenase reductase Sdr
LAC30SC_RS08525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LAC30SC_RS08535	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LAC30SC_RS08540	COG1846	Transcriptional regulator
LAC30SC_RS08565	COG2244	polysaccharide biosynthetic process
LAC30SC_RS08570	COG0495	leucyl-tRNA aminoacylation
LAC30SC_RS08575	COG0671	phosphoesterase, PA-phosphatase related
LAC30SC_RS08580	COG0477	Major facilitator Superfamily
LAC30SC_RS08585	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LAC30SC_RS08630	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LAC30SC_RS08640	COG0398	Pfam SNARE associated Golgi protein
LAC30SC_RS08660	COG1012	belongs to the aldehyde dehydrogenase family
LAC30SC_RS08680	COG3583	domain protein
LAC30SC_RS08680	COG3064	Membrane
LAC30SC_RS08680	COG3525	Glycosyl hydrolase, family 20, catalytic domain
LAC30SC_RS08690	COG2409	Drug exporters of the RND superfamily
LAC30SC_RS08690	COG1033	growth of symbiont in host cell
LAC30SC_RS08725	COG1175	transmembrane transport
LAC30SC_RS08745	COG2176	DNA-directed DNA polymerase activity
LAC30SC_RS08790	COG1132	(ABC) transporter
LAC30SC_RS08795	COG2267	carboxylic ester hydrolase activity
LAC30SC_RS08800	COG0745	RESPONSE REGULATOR receiver
LAC30SC_RS08805	COG5002	protein histidine kinase activity
LAC30SC_RS08825	COG1846	Transcriptional regulator
LAC30SC_RS08830	COG4166	transmembrane transport
LAC30SC_RS08845	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LAC30SC_RS08860	COG2153	protein acetylation
LAC30SC_RS08865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LAC30SC_RS08870	COG1126	abc transporter atp-binding protein
LAC30SC_RS08875	COG0765	amino acid transport
LAC30SC_RS08880	COG3973	AAA domain
LAC30SC_RS08890	COG0588	phosphoglycerate mutase activity
LAC30SC_RS08900	COG1136	(ABC) transporter
LAC30SC_RS08925	COG0252	asparaginase activity
LAC30SC_RS08955	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LAC30SC_RS08970	COG0561	phosphatase activity
LAC30SC_RS08995	COG1917	Cupin 2, conserved barrel domain protein
LAC30SC_RS08995	COG4977	sequence-specific DNA binding
LAC30SC_RS09035	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LAC30SC_RS09040	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
LAC30SC_RS09055	COG1091	dTDP-4-dehydrorhamnose reductase activity
LAC30SC_RS09075	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LAC30SC_RS09085	COG4372	Transposase
LAC30SC_RS09105	COG2801	Transposase and inactivated derivatives
LAC30SC_RS09120	COG0562	UDP-galactopyranose mutase
LAC30SC_RS09125	COG1216	Glycosyl transferase, family 2
LAC30SC_RS09125	COG1442	glycosyl transferase family 8
LAC30SC_RS09130	COG1216	Glycosyl transferase, family 2
LAC30SC_RS09135	COG0438	transferase activity, transferring glycosyl groups
LAC30SC_RS09140	COG0438	transferase activity, transferring glycosyl groups
LAC30SC_RS09150	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LAC30SC_RS09155	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LAC30SC_RS09160	COG4464	protein tyrosine phosphatase activity
LAC30SC_RS09165	COG0489	protein tyrosine kinase activity
LAC30SC_RS09175	COG1316	TRANSCRIPTIONal
LAC30SC_RS09180	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LAC30SC_RS09215	COG0791	NLP P60 protein
LAC30SC_RS09220	COG0791	NLP P60 protein
LAC30SC_RS09250	COG1780	Probably involved in ribonucleotide reductase function
LAC30SC_RS09260	COG4990	cell redox homeostasis
LAC30SC_RS09275	COG0488	(ABC) transporter
LAC30SC_RS09290	COG1811	Na channel or pump
LAC30SC_RS09295	COG1316	TRANSCRIPTIONal
LAC30SC_RS09300	COG1164	Oligoendopeptidase f
LAC30SC_RS09305	COG1373	ATPase (AAA superfamily
LAC30SC_RS09315	COG1620	l-lactate permease
LAC30SC_RS09390	COG1121	(ABC) transporter
LAC30SC_RS09395	COG0803	Belongs to the bacterial solute-binding protein 9 family
LAC30SC_RS09400	COG0640	Transcriptional regulator
LAC30SC_RS09410	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LAC30SC_RS09410	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LAC30SC_RS09410	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LAC30SC_RS09415	COG1105	Belongs to the carbohydrate kinase PfkB family
LAC30SC_RS09435	COG4372	Transposase
LAC30SC_RS09440	COG1668	transmembrane transport
LAC30SC_RS09445	COG4152	abc transporter atp-binding protein
LAC30SC_RS09465	COG3655	Transcriptional regulator
LAC30SC_RS09505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LAC30SC_RS09510	COG2274	protein secretion by the type I secretion system
LAC30SC_RS09555	COG0457	Tetratricopeptide repeat
LAC30SC_RS09555	COG0463	Glycosyl transferase, family 2
LAC30SC_RS09610	COG0675	Transposase, IS605 OrfB family
LAC30SC_RS09625	COG1304	FMN binding
LAC30SC_RS09635	COG1794	racemase activity, acting on amino acids and derivatives
LAC30SC_RS09640	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LAC30SC_RS09655	COG1132	(ABC) transporter
LAC30SC_RS09660	COG1132	(ABC) transporter
LAC30SC_RS09670	COG0012	GTP binding
LAC30SC_RS09675	COG4481	Protein conserved in bacteria
LAC30SC_RS09680	COG1475	DNA binding
LAC30SC_RS09685	COG1192	Involved in chromosome partitioning
LAC30SC_RS09695	COG0357	Ribosomal RNA small subunit methyltransferase G
LAC30SC_RS09715	COG0431	NADPH-dependent FMN reductase
LAC30SC_RS09720	COG0431	NADPH-dependent FMN reductase
LAC30SC_RS09740	COG1136	(ABC) transporter
LAC30SC_RS09755	COG0406	alpha-ribazole phosphatase activity
LAC30SC_RS09765	COG3022	response to hydroperoxide
LAC30SC_RS09775	COG3104	oligopeptide transport
LAC30SC_RS09790	COG2364	Membrane
LAC30SC_RS09800	COG0308	aminopeptidase N
LAC30SC_RS09860	COG3833	ABC-type maltose transport systems, permease component
LAC30SC_RS09865	COG1175	transmembrane transport
LAC30SC_RS09875	COG3842	ATPase activity
LAC30SC_RS09880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LAC30SC_RS09895	COG0366	Alpha amylase catalytic
LAC30SC_RS09900	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LAC30SC_RS09905	COG1609	Transcriptional regulator
LAC30SC_RS09910	COG2365	Tyrosine phosphatase family
LAC30SC_RS09915	COG1132	(ABC) transporter
LAC30SC_RS09925	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LAC30SC_RS09930	COG0351	phosphomethylpyrimidine kinase
LAC30SC_RS09940	COG3442	glutamine amidotransferase
LAC30SC_RS09945	COG0791	NLP P60 protein
LAC30SC_RS09980	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LAC30SC_RS09985	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LAC30SC_RS09990	COG0516	GMP reductase activity
LAC30SC_RS10010	COG2502	aspartate--ammonia ligase
LAC30SC_RS10020	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LAC30SC_RS10025	COG1113	amino acid transport
LAC30SC_RS10030	COG1113	amino acid transport
LAC30SC_RS10045	COG0542	response to heat
LAC30SC_RS10060	COG0577	efflux transmembrane transporter activity
LAC30SC_RS10060	COG1136	(ABC) transporter
LAC30SC_RS10075	COG2244	polysaccharide biosynthetic process
LAC30SC_RS10100	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
LAC30SC_RS10105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LAC30SC_RS10110	COG1696	Membrane protein involved in D-alanine export
LAC30SC_RS10115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LAC30SC_RS10140	COG2217	Heavy metal translocating P-type atpase
LAC30SC_RS10155	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LAC30SC_RS10170	COG1396	sequence-specific DNA binding
LAC30SC_RS10185	COG1136	(ABC) transporter
LAC30SC_RS10185	COG0577	efflux transmembrane transporter activity
LAC30SC_RS10195	COG1744	ABC transporter substrate-binding protein PnrA-like
LAC30SC_RS10200	COG0656	L-ascorbic acid biosynthetic process
LAC30SC_RS10205	COG0363	glucosamine-6-phosphate deaminase activity
LAC30SC_RS10215	COG1428	Deoxynucleoside kinase
LAC30SC_RS10220	COG1428	Deoxynucleoside kinase
LAC30SC_RS10225	COG0561	phosphatase activity
LAC30SC_RS10230	COG2252	PERMEase
LAC30SC_RS10235	COG0789	Transcriptional regulator
LAC30SC_RS10240	COG2252	PERMEase
LAC30SC_RS10245	COG2252	PERMEase
LAC30SC_RS10260	COG4166	transmembrane transport
LAC30SC_RS10285	COG2217	Heavy metal translocating P-type atpase
LAC30SC_RS10290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LAC30SC_RS10305	COG4948	Mandelate Racemase Muconate Lactonizing
LAC30SC_RS10310	COG3775	system Galactitol-specific IIC component
LAC30SC_RS10315	COG3414	Phosphotransferase system galactitol-specific IIB component
LAC30SC_RS10320	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LAC30SC_RS10320	COG2213	PTS system mannitol-specific
LAC30SC_RS10325	COG0800	Aldolase
LAC30SC_RS10375	COG0028	Belongs to the TPP enzyme family
LAC30SC_RS10380	COG0445	tRNA wobble uridine modification
LAC30SC_RS10385	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LAC30SC_RS10390	COG0706	membrane insertase activity
LAC30SC_RS10395	COG0594	ribonuclease P activity
LAC30SC_RS10400	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LAC30SC_RS10410	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LAC30SC_RS10475	COG0187	DNA topoisomerase II activity
LAC30SC_RS10530	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LAC30SC_RS10535	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LAC30SC_RS10550	COG0471	metal ion transport
LAC30SC_RS10555	COG0471	metal ion transport
LAC30SC_RS10595	COG0527	aspartate kinase activity
LAC30SC_RS10600	COG0527	aspartate kinase activity