locus-tag	class	description
LACT_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LACT_RS00015	COG2501	S4 domain
LACT_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LACT_RS00025	COG0187	DNA topoisomerase II activity
LACT_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LACT_RS00035	COG0360	Binds together with S18 to 16S ribosomal RNA
LACT_RS00040	COG0629	single-stranded DNA binding
LACT_RS00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LACT_RS00055	COG0359	binds to the 23S rRNA
LACT_RS00060	COG0305	Participates in initiation and elongation during chromosome replication
LACT_RS00070	COG1307	EDD domain protein, DegV family
LACT_RS00075	COG1940	carbohydrate kinase activity
LACT_RS00080	COG3237	CsbD-like
LACT_RS00085	COG2261	transglycosylase associated protein
LACT_RS00105	COG0640	Transcriptional regulator
LACT_RS00175	COG4690	dipeptidase activity
LACT_RS00190	COG2096	Adenosyltransferase
LACT_RS00205	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LACT_RS00210	COG0628	permease
LACT_RS00235	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LACT_RS00250	COG1011	Hydrolase
LACT_RS00260	COG0561	phosphatase activity
LACT_RS00275	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LACT_RS00280	COG0708	Exodeoxyribonuclease III
LACT_RS00285	COG0531	amino acid
LACT_RS00290	COG0513	Belongs to the DEAD box helicase family
LACT_RS00330	COG1053	succinate dehydrogenase
LACT_RS00330	COG3976	FMN-binding domain protein
LACT_RS00335	COG3976	FMN-binding domain protein
LACT_RS00335	COG1053	succinate dehydrogenase
LACT_RS00340	COG3976	FMN-binding domain protein
LACT_RS00340	COG1053	succinate dehydrogenase
LACT_RS00345	COG0583	DNA-binding transcription factor activity
LACT_RS00370	COG1442	glycosyl transferase family 8
LACT_RS00385	COG1132	(ABC) transporter
LACT_RS00410	COG0745	RESPONSE REGULATOR receiver
LACT_RS00415	COG5002	protein histidine kinase activity
LACT_RS00430	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LACT_RS00435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LACT_RS00440	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LACT_RS00470	COG2267	carboxylic ester hydrolase activity
LACT_RS00480	COG1122	ATPase activity
LACT_RS00490	COG0501	Belongs to the peptidase M48B family
LACT_RS00495	COG1704	LemA family
LACT_RS00500	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LACT_RS00530	COG1215	transferase activity, transferring glycosyl groups
LACT_RS00555	COG1126	abc transporter atp-binding protein
LACT_RS00560	COG0765	amino acid transport
LACT_RS00565	COG2094	Belongs to the DNA glycosylase MPG family
LACT_RS00570	COG3189	MarR family transcriptional regulator
LACT_RS00575	COG0861	Integral membrane protein TerC family
LACT_RS00580	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LACT_RS00590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LACT_RS00600	COG0328	RNA-DNA hybrid ribonuclease activity
LACT_RS00610	COG1216	Glycosyl transferase, family 2
LACT_RS00630	COG2801	Transposase and inactivated derivatives
LACT_RS00650	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LACT_RS00665	COG0765	amino acid transport
LACT_RS00670	COG1126	abc transporter atp-binding protein
LACT_RS00680	COG1181	Belongs to the D-alanine--D-alanine ligase family
LACT_RS00735	COG2365	Tyrosine phosphatase family
LACT_RS00740	COG0589	response to stress
LACT_RS00755	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LACT_RS00765	COG3639	organic phosphonate transmembrane transporter activity
LACT_RS00770	COG0519	Catalyzes the synthesis of GMP from XMP
LACT_RS00785	COG0367	asparagine synthase
LACT_RS00800	COG0602	queuosine metabolic process
LACT_RS00805	COG2151	metal-sulfur cluster biosynthetic enzyme
LACT_RS00815	COG2814	Major facilitator Superfamily
LACT_RS00820	COG3590	peptidase
LACT_RS00865	COG1388	LysM domain
LACT_RS00865	COG1705	Flagellar rod assembly protein muramidase FlgJ
LACT_RS00875	COG0569	domain protein
LACT_RS00875	COG0475	glutathione-regulated potassium exporter activity
LACT_RS00880	COG0673	inositol 2-dehydrogenase activity
LACT_RS00895	COG0588	phosphoglycerate mutase activity
LACT_RS00900	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
LACT_RS00910	COG1316	TRANSCRIPTIONal
LACT_RS00915	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LACT_RS00920	COG1368	sulfuric ester hydrolase activity
LACT_RS00930	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LACT_RS00945	COG3579	cysteine-type endopeptidase activity
LACT_RS00950	COG1418	mRNA catabolic process
LACT_RS00955	COG4166	transmembrane transport
LACT_RS00960	COG4166	transmembrane transport
LACT_RS00965	COG0517	IMP dehydrogenase activity
LACT_RS00965	COG0516	GMP reductase activity
LACT_RS00970	COG0601	transmembrane transport
LACT_RS00975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LACT_RS00980	COG0444	Belongs to the ABC transporter superfamily
LACT_RS00985	COG4608	Belongs to the ABC transporter superfamily
LACT_RS00990	COG3579	cysteine-type endopeptidase activity
LACT_RS01000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LACT_RS01025	COG2131	deaminase
LACT_RS01035	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LACT_RS01040	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LACT_RS01040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LACT_RS01045	COG0084	hydrolase, TatD family'
LACT_RS01055	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LACT_RS01060	COG4466	Protein conserved in bacteria
LACT_RS01065	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LACT_RS01070	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LACT_RS01095	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LACT_RS01100	COG2723	6-phospho-beta-galactosidase activity
LACT_RS01105	COG1737	Transcriptional regulator
LACT_RS01110	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LACT_RS01125	COG1078	dGTPase activity
LACT_RS01135	COG3343	RNA polymerase activity
LACT_RS01140	COG0504	CTP synthase activity
LACT_RS01145	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LACT_RS01170	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LACT_RS01180	COG1396	sequence-specific DNA binding
LACT_RS01185	COG0519	Catalyzes the synthesis of GMP from XMP
LACT_RS01195	COG1131	(ABC) transporter
LACT_RS01215	COG0456	acetyltransferase
LACT_RS01225	COG2814	Major facilitator Superfamily
LACT_RS01245	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LACT_RS01275	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LACT_RS01280	COG0531	amino acid
LACT_RS01285	COG0561	phosphatase activity
LACT_RS01290	COG0366	Alpha amylase catalytic
LACT_RS01295	COG0254	rRNA binding
LACT_RS01300	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LACT_RS01310	COG0736	holo-[acyl-carrier-protein] synthase activity
LACT_RS01315	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LACT_RS01325	COG0039	L-malate dehydrogenase activity
LACT_RS01330	COG0193	aminoacyl-tRNA hydrolase activity
LACT_RS01335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LACT_RS01340	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LACT_RS01355	COG0037	tRNA processing
LACT_RS01365	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LACT_RS01370	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LACT_RS01375	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LACT_RS01395	COG1956	GAF domain-containing protein
LACT_RS01400	COG0542	response to heat
LACT_RS01405	COG0085	RNA polymerase activity
LACT_RS01410	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LACT_RS01420	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LACT_RS01425	COG0049	tRNA binding
LACT_RS01430	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LACT_RS01435	COG0051	transcription antitermination factor activity, RNA binding
LACT_RS01440	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LACT_RS01445	COG0088	Forms part of the polypeptide exit tunnel
LACT_RS01450	COG0089	rRNA binding
LACT_RS01455	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LACT_RS01465	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LACT_RS01470	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LACT_RS01475	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LACT_RS01480	COG0255	Belongs to the universal ribosomal protein uL29 family
LACT_RS01485	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LACT_RS01490	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LACT_RS01495	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LACT_RS01500	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LACT_RS01510	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LACT_RS01515	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LACT_RS01520	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LACT_RS01525	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LACT_RS01530	COG1841	ribosomal large subunit assembly
LACT_RS01535	COG0200	Binds to the 23S rRNA
LACT_RS01545	COG0563	adenylate kinase activity
LACT_RS01550	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LACT_RS01560	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LACT_RS01565	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LACT_RS01570	COG0202	RNA polymerase activity
LACT_RS01575	COG0203	ribosomal protein L17
LACT_RS01580	COG1122	ATPase activity
LACT_RS01585	COG1122	ATPase activity
LACT_RS01590	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LACT_RS01595	COG0101	tRNA pseudouridine synthase activity
LACT_RS01600	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LACT_RS01610	COG0582	viral genome integration into host DNA
LACT_RS01645	COG1002	Type II restriction enzyme, methylase subunits
LACT_RS01675	COG1011	Hydrolase
LACT_RS01690	COG1230	cation diffusion facilitator family transporter
LACT_RS01700	COG0588	phosphoglycerate mutase activity
LACT_RS01720	COG0756	dUTP diphosphatase activity
LACT_RS01730	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LACT_RS01735	COG0215	cysteine-tRNA ligase activity
LACT_RS01740	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
LACT_RS01745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LACT_RS01765	COG1070	Carbohydrate kinase
LACT_RS01775	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LACT_RS01785	COG0250	Participates in transcription elongation, termination and antitermination
LACT_RS01790	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LACT_RS01795	COG0081	regulation of translation
LACT_RS01805	COG0573	inorganic phosphate transmembrane transporter activity
LACT_RS01810	COG0581	inorganic phosphate transmembrane transporter activity
LACT_RS01815	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LACT_RS01820	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LACT_RS01825	COG0704	Plays a role in the regulation of phosphate uptake
LACT_RS01830	COG0679	Auxin Efflux Carrier
LACT_RS01840	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LACT_RS01845	COG0222	ribosome binding
LACT_RS01855	COG2813	Specifically methylates the guanine in position
LACT_RS01865	COG0590	tRNA wobble adenosine to inosine editing
LACT_RS01870	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LACT_RS01880	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LACT_RS01885	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LACT_RS01895	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LACT_RS01900	COG3870	Protein conserved in bacteria
LACT_RS01905	COG0470	DNA polymerase III
LACT_RS01925	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
LACT_RS01930	COG1214	PFAM Peptidase M22, glycoprotease
LACT_RS01935	COG0456	acetyltransferase
LACT_RS01940	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LACT_RS01945	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LACT_RS01955	COG2188	Transcriptional regulator
LACT_RS01975	COG0488	(ABC) transporter
LACT_RS01980	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
LACT_RS01990	COG1621	beta-fructofuranosidase activity
LACT_RS01995	COG2190	(PTS) system
LACT_RS01995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LACT_RS01995	COG1263	PTS System
LACT_RS02015	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LACT_RS02020	COG0459	protein refolding
LACT_RS02025	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LACT_RS02030	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LACT_RS02035	COG0632	four-way junction helicase activity
LACT_RS02040	COG2255	four-way junction helicase activity
LACT_RS02050	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LACT_RS02055	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LACT_RS02060	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LACT_RS02065	COG0513	Belongs to the DEAD box helicase family
LACT_RS02070	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LACT_RS02075	COG4472	Bacterial protein of unknown function (DUF965)
LACT_RS02080	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LACT_RS02085	COG3906	Belongs to the UPF0473 family
LACT_RS02090	COG1193	negative regulation of DNA recombination
LACT_RS02095	COG3118	belongs to the thioredoxin family
LACT_RS02100	COG1970	mechanosensitive ion channel activity
LACT_RS02110	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LACT_RS02115	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LACT_RS02120	COG0668	transmembrane transport
LACT_RS02135	COG0006	proline dipeptidase activity
LACT_RS02145	COG0584	glycerophosphoryl diester phosphodiesterase
LACT_RS02155	COG0737	Belongs to the 5'-nucleotidase family
LACT_RS02165	COG0647	UMP catabolic process
LACT_RS02175	COG0586	Pfam SNARE associated Golgi protein
LACT_RS02180	COG0492	ferredoxin-NADP+ reductase activity
LACT_RS02290	COG0494	nUDIX hydrolase
LACT_RS02360	COG0438	transferase activity, transferring glycosyl groups
LACT_RS02365	COG0438	transferase activity, transferring glycosyl groups
LACT_RS02375	COG1368	sulfuric ester hydrolase activity
LACT_RS02385	COG0557	exoribonuclease II activity
LACT_RS02390	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LACT_RS02420	COG3715	PTS system
LACT_RS02425	COG3716	PTS system mannose fructose sorbose family IID component
LACT_RS02435	COG0583	DNA-binding transcription factor activity
LACT_RS02440	COG0110	maltose O-acetyltransferase activity
LACT_RS02445	COG1113	amino acid transport
LACT_RS02450	COG1454	alcohol dehydrogenase
LACT_RS02450	COG1012	belongs to the aldehyde dehydrogenase family
LACT_RS02455	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LACT_RS02460	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LACT_RS02470	COG0494	nUDIX hydrolase
LACT_RS02490	COG1205	dead DEAH box helicase
LACT_RS02490	COG1111	helicase
LACT_RS02500	COG0004	ammonium transporteR
LACT_RS02595	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LACT_RS02615	COG0588	phosphoglycerate mutase activity
LACT_RS02630	COG0584	glycerophosphoryl diester phosphodiesterase
LACT_RS02640	COG1609	Transcriptional regulator
LACT_RS02650	COG1175	transmembrane transport
LACT_RS02655	COG0395	ABC-type sugar transport system, permease component
LACT_RS02660	COG1621	beta-fructofuranosidase activity
LACT_RS02665	COG3842	ATPase activity
LACT_RS02670	COG0366	Alpha amylase catalytic
LACT_RS02715	COG2188	Transcriptional regulator
LACT_RS02725	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
LACT_RS02735	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LACT_RS02750	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LACT_RS02765	COG3091	SprT-like family
LACT_RS02775	COG1705	Flagellar rod assembly protein muramidase FlgJ
LACT_RS02785	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LACT_RS02790	COG4851	CamS sex pheromone cAM373 precursor
LACT_RS02795	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LACT_RS02800	COG0154	amidase activity
LACT_RS02805	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LACT_RS02810	COG1597	lipid kinase activity
LACT_RS02815	COG0670	Belongs to the BI1 family
LACT_RS02825	COG1757	Na H antiporter
LACT_RS02830	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LACT_RS02845	COG2217	Heavy metal translocating P-type atpase
LACT_RS02855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LACT_RS02860	COG1573	uracil-dna glycosylase
LACT_RS02920	COG2814	Major facilitator Superfamily
LACT_RS02930	COG1309	transcriptional regulator
LACT_RS02935	COG4716	Myosin-crossreactive antigen
LACT_RS02945	COG0656	L-ascorbic acid biosynthetic process
LACT_RS02975	COG2814	Major facilitator Superfamily
LACT_RS02980	COG2814	Major facilitator Superfamily
LACT_RS02995	COG0488	(ABC) transporter
LACT_RS03005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LACT_RS03015	COG1132	(ABC) transporter
LACT_RS03020	COG1132	(ABC) transporter
LACT_RS03030	COG0572	uridine kinase
LACT_RS03040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LACT_RS03045	COG0765	amino acid transport
LACT_RS03050	COG0765	amino acid transport
LACT_RS03080	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LACT_RS03085	COG3158	transport of potassium into the cell
LACT_RS03095	COG2188	Transcriptional regulator
LACT_RS03115	COG0561	phosphatase activity
LACT_RS03125	COG1132	(ABC) transporter
LACT_RS03140	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
LACT_RS03165	COG0561	phosphatase activity
LACT_RS03170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LACT_RS03170	COG1263	PTS System
LACT_RS03175	COG1737	Transcriptional regulator
LACT_RS03185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LACT_RS03185	COG2190	(PTS) system
LACT_RS03185	COG1263	PTS System
LACT_RS03200	COG1253	flavin adenine dinucleotide binding
LACT_RS03210	COG2801	Transposase and inactivated derivatives
LACT_RS03215	COG0531	amino acid
LACT_RS03225	COG0513	Belongs to the DEAD box helicase family
LACT_RS03230	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LACT_RS03245	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LACT_RS03255	COG0716	FMN binding
LACT_RS03260	COG0024	Methionine aminopeptidase
LACT_RS03265	COG1295	ribonuclease BN
LACT_RS03270	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LACT_RS03275	COG0183	Belongs to the thiolase family
LACT_RS03285	COG3425	synthase
LACT_RS03295	COG1073	alpha beta
LACT_RS03305	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LACT_RS03330	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LACT_RS03340	COG0542	response to heat
LACT_RS03350	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LACT_RS03360	COG1393	Belongs to the ArsC family
LACT_RS03365	COG4862	establishment of competence for transformation
LACT_RS03375	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LACT_RS03385	COG2357	RelA SpoT domain protein
LACT_RS03390	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LACT_RS03395	COG0564	pseudouridine synthase activity
LACT_RS03410	COG2706	6-phosphogluconolactonase activity
LACT_RS03415	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LACT_RS03425	COG0628	permease
LACT_RS03440	COG1674	ftsk spoiiie
LACT_RS03450	COG0612	Peptidase, M16
LACT_RS03455	COG1028	Short-chain dehydrogenase reductase Sdr
LACT_RS03460	COG1426	Protein conserved in bacteria
LACT_RS03465	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LACT_RS03470	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LACT_RS03475	COG1418	mRNA catabolic process
LACT_RS03480	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LACT_RS03485	COG1739	Uncharacterized protein family UPF0029
LACT_RS03490	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
LACT_RS03505	COG0653	protein targeting
LACT_RS03510	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LACT_RS03520	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LACT_RS03525	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LACT_RS03530	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LACT_RS03535	COG0492	ferredoxin-NADP+ reductase activity
LACT_RS03540	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LACT_RS03545	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LACT_RS03550	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LACT_RS03555	COG0297	glycogen (starch) synthase activity
LACT_RS03560	COG0058	SHG alpha-glucan phosphorylase activity
LACT_RS03565	COG3103	Sh3 type 3 domain protein
LACT_RS03565	COG0366	Alpha amylase catalytic
LACT_RS03570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LACT_RS03575	COG0556	nucleotide-excision repair
LACT_RS03580	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LACT_RS03590	COG1660	Displays ATPase and GTPase activities
LACT_RS03595	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LACT_RS03600	COG1481	regulation of sporulation
LACT_RS03605	COG0740	serine-type endopeptidase activity
LACT_RS03615	COG0531	amino acid
LACT_RS03625	COG2390	Transcriptional regulator
LACT_RS03635	COG0126	phosphoglycerate kinase activity
LACT_RS03640	COG0149	triose-phosphate isomerase activity
LACT_RS03650	COG0561	phosphatase activity
LACT_RS03655	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LACT_RS03660	COG0280	phosphate acetyltransferase
LACT_RS03665	COG0802	atpase or kinase
LACT_RS03675	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LACT_RS03680	COG3842	ATPase activity
LACT_RS03685	COG1176	ABC-type spermidine putrescine transport system, permease component I
LACT_RS03690	COG1176	ABC-type spermidine putrescine transport system, permease component I
LACT_RS03705	COG4856	YbbR-like protein
LACT_RS03710	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LACT_RS03715	COG0561	phosphatase activity
LACT_RS03720	COG0561	phosphatase activity
LACT_RS03730	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LACT_RS03735	COG1929	Belongs to the glycerate kinase type-1 family
LACT_RS03740	COG3711	transcriptional antiterminator
LACT_RS03745	COG1263	PTS System
LACT_RS03745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LACT_RS03745	COG2190	(PTS) system
LACT_RS03760	COG0531	amino acid
LACT_RS03775	COG0217	transcriptional regulatory protein
LACT_RS03780	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LACT_RS03810	COG0827	DNA restriction-modification system
LACT_RS03825	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LACT_RS03835	COG1482	cell wall glycoprotein biosynthetic process
LACT_RS03845	COG0745	RESPONSE REGULATOR receiver
LACT_RS03850	COG3850	Histidine kinase
LACT_RS03850	COG5002	protein histidine kinase activity
LACT_RS03860	COG1368	sulfuric ester hydrolase activity
LACT_RS03870	COG0166	Belongs to the GPI family
LACT_RS03875	COG0477	Major facilitator Superfamily
LACT_RS03880	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LACT_RS03945	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LACT_RS03950	COG1435	thymidine kinase activity
LACT_RS03955	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LACT_RS03960	COG2890	protein-(glutamine-N5) methyltransferase activity
LACT_RS03965	COG0009	L-threonylcarbamoyladenylate synthase
LACT_RS03970	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LACT_RS03975	COG0356	it plays a direct role in the translocation of protons across the membrane
LACT_RS03980	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LACT_RS03985	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LACT_RS03990	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LACT_RS03995	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LACT_RS04000	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LACT_RS04005	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LACT_RS04010	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LACT_RS04020	COG1077	Cell shape determining protein MreB Mrl
LACT_RS04025	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LACT_RS04035	COG0772	Belongs to the SEDS family
LACT_RS04040	COG0589	response to stress
LACT_RS04050	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LACT_RS04060	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LACT_RS04065	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
LACT_RS04070	COG1104	cysteine desulfurase activity
LACT_RS04075	COG0301	tRNA thio-modification
LACT_RS04080	COG1187	pseudouridine synthase activity
LACT_RS04095	COG0525	valine-tRNA ligase activity
LACT_RS04105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LACT_RS04110	COG2003	Belongs to the UPF0758 family
LACT_RS04115	COG1077	Cell shape determining protein MreB Mrl
LACT_RS04120	COG1792	Involved in formation and maintenance of cell shape
LACT_RS04135	COG2001	Belongs to the MraZ family
LACT_RS04140	COG0275	rRNA processing
LACT_RS04150	COG0768	penicillin binding
LACT_RS04155	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LACT_RS04160	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LACT_RS04165	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LACT_RS04170	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LACT_RS04180	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LACT_RS04185	COG1799	cell septum assembly
LACT_RS04200	COG3599	regulation of cell shape
LACT_RS04205	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LACT_RS04210	COG1278	Cold shock
LACT_RS04215	COG0494	nUDIX hydrolase
LACT_RS04225	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LACT_RS04235	COG0482	sulfurtransferase activity
LACT_RS04240	COG0406	alpha-ribazole phosphatase activity
LACT_RS04250	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LACT_RS04260	COG1597	lipid kinase activity
LACT_RS04270	COG5503	Protein of unknown function (DUF1447)
LACT_RS04275	COG0242	peptide deformylase activity
LACT_RS04280	COG1217	gtp-binding protein TYPA
LACT_RS04285	COG0772	Belongs to the SEDS family
LACT_RS04295	COG0742	ribosomal rna small subunit methyltransferase
LACT_RS04300	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LACT_RS04305	COG3480	Lon protease (S16) C-terminal proteolytic domain
LACT_RS04310	COG1596	polysaccharide export
LACT_RS04310	COG1555	photosystem II stabilization
LACT_RS04315	COG0658	competence protein
LACT_RS04315	COG2333	competence protein COMEC
LACT_RS04320	COG1466	dna polymerase III delta subunit
LACT_RS04325	COG0268	Binds directly to 16S ribosomal RNA
LACT_RS04330	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LACT_RS04345	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LACT_RS04350	COG0544	peptidyl-prolyl cis-trans isomerase activity
LACT_RS04355	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LACT_RS04360	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LACT_RS04370	COG0527	aspartate kinase activity
LACT_RS04375	COG0019	diaminopimelate decarboxylase activity
LACT_RS04380	COG2171	N-acyltransferase activity
LACT_RS04385	COG1473	amidohydrolase
LACT_RS04390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LACT_RS04395	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LACT_RS04400	COG0436	Aminotransferase
LACT_RS04405	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LACT_RS04410	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LACT_RS04420	COG3976	FMN-binding domain protein
LACT_RS04420	COG1053	succinate dehydrogenase
LACT_RS04420	COG0431	NADPH-dependent FMN reductase
LACT_RS04435	COG1957	nucleoside hydrolase
LACT_RS04470	COG2261	transglycosylase associated protein
LACT_RS04480	COG2723	6-phospho-beta-galactosidase activity
LACT_RS04485	COG2188	Transcriptional regulator
LACT_RS04490	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LACT_RS04495	COG1447	Phosphotransferase system cellobiose-specific component IIA
LACT_RS04505	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LACT_RS04515	COG2723	6-phospho-beta-galactosidase activity
LACT_RS04520	COG2188	Transcriptional regulator
LACT_RS04530	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LACT_RS04535	COG2723	6-phospho-beta-galactosidase activity
LACT_RS04555	COG0148	phosphopyruvate hydratase activity
LACT_RS04570	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
LACT_RS04610	COG1113	amino acid transport
LACT_RS04615	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LACT_RS04625	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LACT_RS04635	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LACT_RS04640	COG2011	ABC-type metal ion transport system permease component
LACT_RS04650	COG1053	succinate dehydrogenase
LACT_RS04660	COG0039	L-malate dehydrogenase activity
LACT_RS04665	COG3579	cysteine-type endopeptidase activity
LACT_RS04670	COG0471	metal ion transport
LACT_RS04675	COG2267	carboxylic ester hydrolase activity
LACT_RS04685	COG3052	prosthetic group binding
LACT_RS04700	COG2707	UPF0756 membrane protein
LACT_RS04710	COG1122	ATPase activity
LACT_RS04715	COG4720	Psort location CytoplasmicMembrane, score
LACT_RS04745	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LACT_RS04750	COG2264	protein methyltransferase activity
LACT_RS04760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LACT_RS04765	COG1490	D-aminoacyl-tRNA deacylase activity
LACT_RS04770	COG0124	histidyl-tRNA synthetase
LACT_RS04775	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LACT_RS04780	COG0436	Aminotransferase
LACT_RS04785	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LACT_RS04790	COG0656	L-ascorbic acid biosynthetic process
LACT_RS04795	COG0561	phosphatase activity
LACT_RS04800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LACT_RS04805	COG0531	amino acid
LACT_RS04810	COG0586	Pfam SNARE associated Golgi protein
LACT_RS04815	COG0322	excinuclease ABC activity
LACT_RS04820	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LACT_RS04825	COG2755	lipolytic protein G-D-S-L family
LACT_RS04825	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LACT_RS04830	COG1234	tRNA 3'-trailer cleavage
LACT_RS04835	COG0300	oxidoreductase activity
LACT_RS04845	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LACT_RS04850	COG0737	Belongs to the 5'-nucleotidase family
LACT_RS04860	COG0587	DNA-directed DNA polymerase activity
LACT_RS04865	COG0205	6-phosphofructokinase activity
LACT_RS04875	COG2996	Protein conserved in bacteria
LACT_RS04885	COG0456	acetyltransferase
LACT_RS04890	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LACT_RS04900	COG1187	pseudouridine synthase activity
LACT_RS04905	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
LACT_RS04910	COG3409	Peptidoglycan-binding domain 1 protein
LACT_RS04910	COG5632	N-Acetylmuramoyl-L-alanine amidase
LACT_RS04915	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LACT_RS04920	COG0539	negative regulation of cytoplasmic translation
LACT_RS04925	COG1160	GTP binding
LACT_RS04940	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LACT_RS04945	COG0617	tRNA 3'-terminal CCA addition
LACT_RS04950	COG1272	protein, Hemolysin III
LACT_RS04955	COG1307	EDD domain protein, DegV family
LACT_RS04960	COG4479	Belongs to the UPF0346 family
LACT_RS04965	COG0025	NhaP-type Na H and K H
LACT_RS04970	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LACT_RS04975	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LACT_RS04980	COG0758	DNA mediated transformation
LACT_RS04985	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LACT_RS04990	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
LACT_RS05005	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LACT_RS05035	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LACT_RS05040	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LACT_RS05050	COG0531	amino acid
LACT_RS05060	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
LACT_RS05065	COG0569	domain protein
LACT_RS05070	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LACT_RS05075	COG0514	ATP-dependent DNA helicase (RecQ)
LACT_RS05085	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LACT_RS05090	COG2040	homocysteine
LACT_RS05130	COG1263	PTS System
LACT_RS05130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LACT_RS05130	COG2190	(PTS) system
LACT_RS05135	COG2188	Transcriptional regulator
LACT_RS05140	COG0366	Alpha amylase catalytic
LACT_RS05175	COG0789	Transcriptional regulator
LACT_RS05175	COG4978	Transcriptional regulator
LACT_RS05190	COG0583	DNA-binding transcription factor activity
LACT_RS05195	COG0656	L-ascorbic acid biosynthetic process
LACT_RS05200	COG0656	L-ascorbic acid biosynthetic process
LACT_RS05205	COG0656	L-ascorbic acid biosynthetic process
LACT_RS05215	COG0456	acetyltransferase
LACT_RS05235	COG1959	2 iron, 2 sulfur cluster binding
LACT_RS05245	COG1114	Component of the transport system for branched-chain amino acids
LACT_RS05250	COG0656	L-ascorbic acid biosynthetic process
LACT_RS05270	COG0765	amino acid transport
LACT_RS05275	COG0765	amino acid transport
LACT_RS05280	COG1126	abc transporter atp-binding protein
LACT_RS05290	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
LACT_RS05300	COG2159	amidohydrolase
LACT_RS05325	COG2814	Major facilitator Superfamily
LACT_RS05335	COG1051	belongs to the nudix hydrolase family
LACT_RS05385	COG0588	phosphoglycerate mutase activity
LACT_RS05400	COG1011	Hydrolase
LACT_RS05435	COG0281	malic enzyme
LACT_RS05445	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LACT_RS05450	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
LACT_RS05455	COG1376	ErfK ybiS ycfS ynhG family protein
LACT_RS05460	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LACT_RS05465	COG1854	S-ribosylhomocysteine lyase activity
LACT_RS05485	COG0531	amino acid
LACT_RS05495	COG0626	cystathionine gamma-synthase activity
LACT_RS05500	COG0626	cystathionine gamma-synthase activity
LACT_RS05510	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LACT_RS05535	COG1028	Short-chain dehydrogenase reductase Sdr
LACT_RS05540	COG1247	-acetyltransferase
LACT_RS05545	COG0667	Aldo Keto reductase
LACT_RS05550	COG0656	L-ascorbic acid biosynthetic process
LACT_RS05555	COG4975	Glucose uptake
LACT_RS05575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LACT_RS05625	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LACT_RS05640	COG2855	membrane
LACT_RS05650	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LACT_RS05655	COG0187	DNA topoisomerase II activity
LACT_RS05665	COG0583	DNA-binding transcription factor activity
LACT_RS05670	COG1227	inorganic diphosphatase activity
LACT_RS05675	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LACT_RS05700	COG1132	(ABC) transporter
LACT_RS05720	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LACT_RS05735	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LACT_RS05750	COG1307	EDD domain protein, DegV family
LACT_RS05765	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LACT_RS05770	COG0505	Belongs to the CarA family
LACT_RS05775	COG0564	pseudouridine synthase activity
LACT_RS05785	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LACT_RS05795	COG0116	Belongs to the methyltransferase superfamily
LACT_RS05800	COG3599	regulation of cell shape
LACT_RS05805	COG4474	Belongs to the UPF0398 family
LACT_RS05810	COG3331	DNA recombination
LACT_RS05815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LACT_RS05820	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LACT_RS05830	COG0017	Asparaginyl-tRNA synthetase
LACT_RS05845	COG1074	ATP-dependent DNA helicase activity
LACT_RS05850	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
LACT_RS05875	COG1737	Transcriptional regulator
LACT_RS05890	COG1104	cysteine desulfurase activity
LACT_RS05895	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
LACT_RS05895	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LACT_RS05935	COG1131	(ABC) transporter
LACT_RS05940	COG1725	Transcriptional regulator
LACT_RS05945	COG2195	Cleaves the N-terminal amino acid of tripeptides
LACT_RS05950	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LACT_RS05955	COG2384	SAM-dependent methyltransferase
LACT_RS05960	COG2816	NAD+ diphosphatase activity
LACT_RS05970	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LACT_RS05975	COG0358	DNA primase activity
LACT_RS05980	COG0751	glycine-tRNA ligase activity
LACT_RS05985	COG0752	glycyl-tRNA synthetase alpha subunit
LACT_RS05990	COG1381	Involved in DNA repair and RecF pathway recombination
LACT_RS05995	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LACT_RS06000	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LACT_RS06005	COG1702	phosphate starvation-inducible protein PhoH
LACT_RS06015	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LACT_RS06020	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LACT_RS06030	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LACT_RS06035	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LACT_RS06045	COG0083	homoserine kinase activity
LACT_RS06060	COG0527	aspartate kinase activity
LACT_RS06065	COG4166	transmembrane transport
LACT_RS06075	COG0110	maltose O-acetyltransferase activity
LACT_RS06090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LACT_RS06095	COG1114	Component of the transport system for branched-chain amino acids
LACT_RS06135	COG0583	DNA-binding transcription factor activity
LACT_RS06140	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LACT_RS06160	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LACT_RS06170	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
LACT_RS06185	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LACT_RS06190	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LACT_RS06190	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LACT_RS06195	COG3764	Sortase (surface protein transpeptidase)
LACT_RS06200	COG0481	GTPase activity
LACT_RS06205	COG0484	heat shock protein binding
LACT_RS06210	COG0443	Heat shock 70 kDa protein
LACT_RS06215	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LACT_RS06220	COG1420	regulation of RNA biosynthetic process
LACT_RS06225	COG0488	(ABC) transporter
LACT_RS06235	COG0196	riboflavin kinase activity
LACT_RS06240	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LACT_RS06245	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LACT_RS06250	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LACT_RS06260	COG2740	Nucleic-acid-binding protein implicated in transcription termination
LACT_RS06265	COG0195	Participates in both transcription termination and antitermination
LACT_RS06270	COG0779	Required for maturation of 30S ribosomal subunits
LACT_RS06280	COG0442	prolyl-tRNA aminoacylation
LACT_RS06285	COG0750	zinc metalloprotease
LACT_RS06290	COG4589	Belongs to the CDS family
LACT_RS06295	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LACT_RS06300	COG0233	cytoplasmic translational termination
LACT_RS06305	COG0528	UMP kinase activity
LACT_RS06310	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LACT_RS06315	COG0052	Belongs to the universal ribosomal protein uS2 family
LACT_RS06320	COG2827	Endonuclease containing a URI domain
LACT_RS06325	COG0204	Acyl-transferase
LACT_RS06330	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LACT_RS06335	COG3590	peptidase
LACT_RS06340	COG1132	(ABC) transporter
LACT_RS06345	COG1132	(ABC) transporter
LACT_RS06350	COG3763	UPF0154 protein
LACT_RS06355	COG4224	UPF0291 protein
LACT_RS06360	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LACT_RS06375	COG0463	Glycosyl transferase, family 2
LACT_RS06390	COG0335	large ribosomal subunit rRNA binding
LACT_RS06395	COG0336	Belongs to the RNA methyltransferase TrmD family
LACT_RS06400	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LACT_RS06405	COG0228	four-way junction DNA binding
LACT_RS06410	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LACT_RS06415	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
LACT_RS06420	COG0531	amino acid
LACT_RS06435	COG0552	protein localization to endoplasmic reticulum
LACT_RS06440	COG1196	nuclear chromosome segregation
LACT_RS06445	COG0571	ribonuclease III activity
LACT_RS06450	COG2801	Transposase and inactivated derivatives
LACT_RS06470	COG0601	transmembrane transport
LACT_RS06475	COG4608	Belongs to the ABC transporter superfamily
LACT_RS06485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LACT_RS06490	COG0416	fatty acid biosynthetic process
LACT_RS06495	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LACT_RS06510	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LACT_RS06525	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LACT_RS06530	COG1162	GTPase activity
LACT_RS06535	COG0515	serine threonine protein kinase
LACT_RS06535	COG2815	serine threonine protein kinase
LACT_RS06540	COG0631	protein serine/threonine phosphatase activity
LACT_RS06545	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LACT_RS06545	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LACT_RS06550	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LACT_RS06555	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LACT_RS06560	COG1758	RNA polymerase activity
LACT_RS06565	COG0194	GDP metabolic process
LACT_RS06575	COG0497	DNA recombination
LACT_RS06580	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
LACT_RS06590	COG1722	exodeoxyribonuclease VII activity
LACT_RS06595	COG1570	exodeoxyribonuclease VII activity
LACT_RS06600	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LACT_RS06610	COG1302	Protein conserved in bacteria
LACT_RS06615	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LACT_RS06620	COG0006	proline dipeptidase activity
LACT_RS06625	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LACT_RS06630	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LACT_RS06635	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LACT_RS06645	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LACT_RS06650	COG1942	4-Oxalocrotonate Tautomerase
LACT_RS06670	COG4166	transmembrane transport
LACT_RS06675	COG3231	kanamycin kinase activity
LACT_RS06715	COG1393	Belongs to the ArsC family
LACT_RS06725	COG1136	(ABC) transporter
LACT_RS06730	COG0561	phosphatase activity
LACT_RS06740	COG1874	Beta-galactosidase
LACT_RS06745	COG1501	Belongs to the glycosyl hydrolase 31 family
LACT_RS06750	COG2723	6-phospho-beta-galactosidase activity
LACT_RS06755	COG1940	carbohydrate kinase activity
LACT_RS06760	COG1940	carbohydrate kinase activity
LACT_RS06760	COG1846	Transcriptional regulator
LACT_RS06765	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LACT_RS06790	COG2936	dipeptidyl-peptidase activity
LACT_RS06795	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LACT_RS06805	COG4975	Glucose uptake
LACT_RS06820	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LACT_RS06825	COG0505	Belongs to the CarA family
LACT_RS06830	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LACT_RS06835	COG0540	Belongs to the ATCase OTCase family
LACT_RS06845	COG0167	dihydroorotate dehydrogenase activity
LACT_RS06855	COG0284	orotidine-5'-phosphate decarboxylase activity
LACT_RS06860	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LACT_RS06870	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LACT_RS06875	COG0038	chloride channel
LACT_RS06900	COG1464	Belongs to the NlpA lipoprotein family
LACT_RS06910	COG1760	l-serine dehydratase
LACT_RS06915	COG1760	l-serine dehydratase
LACT_RS06920	COG2151	metal-sulfur cluster biosynthetic enzyme
LACT_RS06930	COG0747	negative chemotaxis
LACT_RS06935	COG0446	pyridine nucleotide-disulphide oxidoreductase
LACT_RS06950	COG0702	epimerase
LACT_RS06955	COG2337	Toxic component of a toxin-antitoxin (TA) module
LACT_RS06985	COG3976	FMN-binding domain protein
LACT_RS06985	COG0431	NADPH-dependent FMN reductase
LACT_RS06985	COG1053	succinate dehydrogenase
LACT_RS06995	COG3706	GGDEF domain
LACT_RS07020	COG1902	pentaerythritol trinitrate reductase activity
LACT_RS07040	COG1335	isochorismatase
LACT_RS07080	COG5002	protein histidine kinase activity
LACT_RS07085	COG0745	RESPONSE REGULATOR receiver
LACT_RS07090	COG2357	RelA SpoT domain protein
LACT_RS07095	COG2376	Dihydroxyacetone kinase
LACT_RS07100	COG1461	Dihydroxyacetone kinase
LACT_RS07105	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
LACT_RS07110	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LACT_RS07115	COG0366	Alpha amylase catalytic
LACT_RS07120	COG3345	alpha-galactosidase
LACT_RS07125	COG3842	ATPase activity
LACT_RS07130	COG0395	ABC-type sugar transport system, permease component
LACT_RS07135	COG1175	transmembrane transport
LACT_RS07140	COG1653	transport
LACT_RS07155	COG2814	Major facilitator Superfamily
LACT_RS07190	COG2017	converts alpha-aldose to the beta-anomer
LACT_RS07195	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
LACT_RS07200	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LACT_RS07215	COG1874	Beta-galactosidase
LACT_RS07220	COG2211	Major facilitator Superfamily
LACT_RS07220	COG2190	(PTS) system
LACT_RS07230	COG1609	Transcriptional regulator
LACT_RS07235	COG3250	beta-galactosidase activity
LACT_RS07240	COG3250	beta-galactosidase activity
LACT_RS07245	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LACT_RS07260	COG1609	Transcriptional regulator
LACT_RS07265	COG3250	beta-galactosidase activity
LACT_RS07275	COG2801	Transposase and inactivated derivatives
LACT_RS07290	COG2190	(PTS) system
LACT_RS07290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LACT_RS07290	COG1263	PTS System
LACT_RS07295	COG3711	transcriptional antiterminator
LACT_RS07305	COG1879	ABC-type sugar transport system periplasmic component
LACT_RS07310	COG1172	Belongs to the binding-protein-dependent transport system permease family
LACT_RS07320	COG1869	D-ribose catabolic process
LACT_RS07340	COG1609	Transcriptional regulator
LACT_RS07345	COG3959	Transketolase, thiamine diphosphate binding domain
LACT_RS07350	COG3958	Transketolase
LACT_RS07355	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LACT_RS07365	COG0477	Major facilitator Superfamily
LACT_RS07375	COG1388	LysM domain
LACT_RS07375	COG2373	Large extracellular alpha-helical protein
LACT_RS07375	COG4932	domain protein
LACT_RS07390	COG4619	ABC transporter
LACT_RS07395	COG0390	transport system, permease component
LACT_RS07410	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LACT_RS07415	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LACT_RS07430	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LACT_RS07435	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LACT_RS07440	COG0768	penicillin binding
LACT_RS07450	COG2971	BadF BadG BcrA BcrD
LACT_RS07470	COG2195	Cleaves the N-terminal amino acid of tripeptides
LACT_RS07485	COG0072	phenylalanine-tRNA ligase activity
LACT_RS07490	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LACT_RS07495	COG1733	regulation of RNA biosynthetic process
LACT_RS07500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LACT_RS07505	COG1254	Belongs to the acylphosphatase family
LACT_RS07510	COG0706	membrane insertase activity
LACT_RS07515	COG5002	protein histidine kinase activity
LACT_RS07520	COG0745	RESPONSE REGULATOR receiver
LACT_RS07530	COG1323	Belongs to the UPF0348 family
LACT_RS07535	COG0799	negative regulation of ribosome biogenesis
LACT_RS07540	COG1713	HD superfamily hydrolase involved in NAD metabolism
LACT_RS07545	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LACT_RS07550	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LACT_RS07555	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
LACT_RS07565	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LACT_RS07570	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LACT_RS07575	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LACT_RS07580	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LACT_RS07600	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LACT_RS07605	COG1484	DNA-dependent DNA replication
LACT_RS07615	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LACT_RS07620	COG0237	dephospho-CoA kinase activity
LACT_RS07625	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LACT_RS07630	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LACT_RS07630	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LACT_RS07635	COG0151	Belongs to the GarS family
LACT_RS07640	COG0138	bifunctional purine biosynthesis protein purh
LACT_RS07645	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LACT_RS07650	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LACT_RS07660	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LACT_RS07665	COG0047	phosphoribosylformylglycinamidine synthase activity
LACT_RS07670	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LACT_RS07675	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LACT_RS07680	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LACT_RS07685	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LACT_RS07690	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LACT_RS07750	COG2190	(PTS) system
LACT_RS07750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LACT_RS07750	COG1263	PTS System
LACT_RS07755	COG1263	PTS System
LACT_RS07755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LACT_RS07755	COG2190	(PTS) system
LACT_RS07770	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LACT_RS07775	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LACT_RS07780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LACT_RS07785	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LACT_RS07795	COG1131	(ABC) transporter
LACT_RS07800	COG0537	adenosine 5'-monophosphoramidase activity
LACT_RS07810	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LACT_RS07815	COG3481	metal-dependent phosphohydrolase, HD sub domain
LACT_RS07830	COG3679	Belongs to the UPF0342 family
LACT_RS07835	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LACT_RS07840	COG0564	pseudouridine synthase activity
LACT_RS07845	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LACT_RS07865	COG0018	arginyl-trna synthetase
LACT_RS07870	COG1376	ErfK ybiS ycfS ynhG family protein
LACT_RS07875	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LACT_RS07880	COG1686	Belongs to the peptidase S11 family
LACT_RS07945	COG2244	polysaccharide biosynthetic process
LACT_RS07950	COG0495	leucyl-tRNA aminoacylation
LACT_RS07955	COG0671	phosphoesterase, PA-phosphatase related
LACT_RS07970	COG0477	Major facilitator Superfamily
LACT_RS07975	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LACT_RS08025	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LACT_RS08035	COG0398	Pfam SNARE associated Golgi protein
LACT_RS08055	COG1012	belongs to the aldehyde dehydrogenase family
LACT_RS08075	COG2409	Drug exporters of the RND superfamily
LACT_RS08075	COG1033	growth of symbiont in host cell
LACT_RS08110	COG1175	transmembrane transport
LACT_RS08130	COG2176	DNA-directed DNA polymerase activity
LACT_RS08175	COG1132	(ABC) transporter
LACT_RS08180	COG2267	carboxylic ester hydrolase activity
LACT_RS08185	COG0745	RESPONSE REGULATOR receiver
LACT_RS08190	COG5002	protein histidine kinase activity
LACT_RS08205	COG1846	Transcriptional regulator
LACT_RS08215	COG4166	transmembrane transport
LACT_RS08230	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LACT_RS08250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LACT_RS08255	COG1126	abc transporter atp-binding protein
LACT_RS08260	COG0765	amino acid transport
LACT_RS08275	COG0588	phosphoglycerate mutase activity
LACT_RS08285	COG1136	(ABC) transporter
LACT_RS08320	COG0252	asparaginase activity
LACT_RS08380	COG0708	Exodeoxyribonuclease III
LACT_RS08385	COG2207	Transcriptional regulator
LACT_RS08400	COG1737	Transcriptional regulator
LACT_RS08410	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LACT_RS08415	COG1263	PTS System
LACT_RS08415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LACT_RS08420	COG2723	6-phospho-beta-galactosidase activity
LACT_RS08425	COG1263	PTS System
LACT_RS08425	COG2190	(PTS) system
LACT_RS08425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LACT_RS08430	COG3711	transcriptional antiterminator
LACT_RS08440	COG1523	belongs to the glycosyl hydrolase 13 family
LACT_RS08500	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LACT_RS08505	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LACT_RS08525	COG2244	polysaccharide biosynthetic process
LACT_RS08565	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LACT_RS08570	COG4464	protein tyrosine phosphatase activity
LACT_RS08575	COG0489	protein tyrosine kinase activity
LACT_RS08585	COG1316	TRANSCRIPTIONal
LACT_RS08590	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LACT_RS08605	COG0791	NLP P60 protein
LACT_RS08610	COG0791	NLP P60 protein
LACT_RS08615	COG0791	NLP P60 protein
LACT_RS08640	COG1780	Probably involved in ribonucleotide reductase function
LACT_RS08655	COG4990	cell redox homeostasis
LACT_RS08660	COG2151	metal-sulfur cluster biosynthetic enzyme
LACT_RS08665	COG0719	Fe-S assembly protein
LACT_RS08685	COG0488	(ABC) transporter
LACT_RS08700	COG1316	TRANSCRIPTIONal
LACT_RS08705	COG1164	Oligoendopeptidase f
LACT_RS08720	COG1620	l-lactate permease
LACT_RS08730	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LACT_RS08735	COG1121	(ABC) transporter
LACT_RS08745	COG0640	Transcriptional regulator
LACT_RS08760	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LACT_RS08760	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LACT_RS08760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LACT_RS08765	COG1105	Belongs to the carbohydrate kinase PfkB family
LACT_RS08770	COG1349	DNA-binding transcription factor activity
LACT_RS08780	COG1668	transmembrane transport
LACT_RS08785	COG4152	abc transporter atp-binding protein
LACT_RS08810	COG3655	Transcriptional regulator
LACT_RS08850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LACT_RS08855	COG2274	protein secretion by the type I secretion system
LACT_RS08945	COG1794	racemase activity, acting on amino acids and derivatives
LACT_RS08950	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LACT_RS08965	COG1132	(ABC) transporter
LACT_RS08970	COG1132	(ABC) transporter
LACT_RS08980	COG0012	GTP binding
LACT_RS08985	COG4481	Protein conserved in bacteria
LACT_RS08990	COG1475	DNA binding
LACT_RS08995	COG1192	Involved in chromosome partitioning
LACT_RS09005	COG0357	Ribosomal RNA small subunit methyltransferase G
LACT_RS09025	COG0431	NADPH-dependent FMN reductase
LACT_RS09030	COG0431	NADPH-dependent FMN reductase
LACT_RS09050	COG1136	(ABC) transporter
LACT_RS09075	COG3022	response to hydroperoxide
LACT_RS09085	COG3104	oligopeptide transport
LACT_RS09100	COG3104	oligopeptide transport
LACT_RS09105	COG0308	aminopeptidase N
LACT_RS09120	COG2814	Major facilitator Superfamily
LACT_RS09140	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
LACT_RS09180	COG3833	ABC-type maltose transport systems, permease component
LACT_RS09185	COG1175	transmembrane transport
LACT_RS09195	COG3842	ATPase activity
LACT_RS09200	COG2801	Transposase and inactivated derivatives
LACT_RS09205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LACT_RS09220	COG0366	Alpha amylase catalytic
LACT_RS09225	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LACT_RS09230	COG1609	Transcriptional regulator
LACT_RS09235	COG2365	Tyrosine phosphatase family
LACT_RS09240	COG1132	(ABC) transporter
LACT_RS09255	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LACT_RS09260	COG0351	phosphomethylpyrimidine kinase
LACT_RS09275	COG3442	glutamine amidotransferase
LACT_RS09280	COG0791	NLP P60 protein
LACT_RS09295	COG0697	spore germination
LACT_RS09310	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LACT_RS09315	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LACT_RS09320	COG0516	GMP reductase activity
LACT_RS09345	COG2502	aspartate--ammonia ligase
LACT_RS09355	COG0492	ferredoxin-NADP+ reductase activity
LACT_RS09360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LACT_RS09380	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LACT_RS09385	COG1113	amino acid transport
LACT_RS09390	COG1113	amino acid transport
LACT_RS09410	COG0542	response to heat
LACT_RS09425	COG0577	efflux transmembrane transporter activity
LACT_RS09425	COG1136	(ABC) transporter
LACT_RS09440	COG2244	polysaccharide biosynthetic process
LACT_RS09470	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
LACT_RS09475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LACT_RS09480	COG1696	Membrane protein involved in D-alanine export
LACT_RS09485	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LACT_RS09505	COG0517	IMP dehydrogenase activity
LACT_RS09505	COG0516	GMP reductase activity
LACT_RS09510	COG2217	Heavy metal translocating P-type atpase
LACT_RS09525	COG1132	(ABC) transporter
LACT_RS09540	COG1396	sequence-specific DNA binding
LACT_RS09555	COG1136	(ABC) transporter
LACT_RS09555	COG0577	efflux transmembrane transporter activity
LACT_RS09555	COG1136	(ABC) transporter
LACT_RS09555	COG0577	efflux transmembrane transporter activity
LACT_RS09565	COG1744	ABC transporter substrate-binding protein PnrA-like
LACT_RS09570	COG1744	ABC transporter substrate-binding protein PnrA-like
LACT_RS09575	COG3845	ABC transporter
LACT_RS09580	COG4603	Belongs to the binding-protein-dependent transport system permease family
LACT_RS09585	COG1079	Belongs to the binding-protein-dependent transport system permease family
LACT_RS09590	COG0656	L-ascorbic acid biosynthetic process
LACT_RS09595	COG0363	glucosamine-6-phosphate deaminase activity
LACT_RS09600	COG1428	Deoxynucleoside kinase
LACT_RS09605	COG1428	Deoxynucleoside kinase
LACT_RS09610	COG0561	phosphatase activity
LACT_RS09615	COG2252	PERMEase
LACT_RS09620	COG2801	Transposase and inactivated derivatives
LACT_RS09630	COG2252	PERMEase
LACT_RS09635	COG2267	carboxylic ester hydrolase activity
LACT_RS09640	COG4166	transmembrane transport
LACT_RS09645	COG2252	PERMEase
LACT_RS09655	COG4166	transmembrane transport
LACT_RS09675	COG2217	Heavy metal translocating P-type atpase
LACT_RS09690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LACT_RS09710	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LACT_RS09715	COG0028	Belongs to the TPP enzyme family
LACT_RS09720	COG0445	tRNA wobble uridine modification
LACT_RS09725	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LACT_RS09730	COG0706	membrane insertase activity
LACT_RS09735	COG0594	ribonuclease P activity
LACT_RS09740	COG0230	Belongs to the bacterial ribosomal protein bL34 family