locus-tag	class	description
BTM29_RS00015	COG1098	S1 RNA binding domain
BTM29_RS00020	COG0492	ferredoxin-NADP+ reductase activity
BTM29_RS00025	COG0586	Pfam SNARE associated Golgi protein
BTM29_RS00035	COG0647	UMP catabolic process
BTM29_RS00040	COG4470	Protein conserved in bacteria
BTM29_RS00045	COG0737	Belongs to the 5'-nucleotidase family
BTM29_RS00060	COG0584	glycerophosphoryl diester phosphodiesterase
BTM29_RS00065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BTM29_RS00070	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BTM29_RS00080	COG1609	Transcriptional regulator
BTM29_RS00085	COG0006	proline dipeptidase activity
BTM29_RS00100	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BTM29_RS00105	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BTM29_RS00115	COG3118	belongs to the thioredoxin family
BTM29_RS00120	COG1193	negative regulation of DNA recombination
BTM29_RS00135	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BTM29_RS00150	COG0513	Belongs to the DEAD box helicase family
BTM29_RS00155	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BTM29_RS00160	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BTM29_RS00165	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BTM29_RS00170	COG1862	Preprotein translocase
BTM29_RS00175	COG0343	queuine tRNA-ribosyltransferase activity
BTM29_RS00180	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BTM29_RS00205	COG1692	metallophosphoesterase
BTM29_RS00210	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BTM29_RS00215	COG1811	Na channel or pump
BTM29_RS00220	COG0789	Transcriptional regulator
BTM29_RS00220	COG4978	Transcriptional regulator
BTM29_RS00225	COG0459	protein refolding
BTM29_RS00250	COG1482	cell wall glycoprotein biosynthetic process
BTM29_RS00260	COG0488	(ABC) transporter
BTM29_RS00275	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BTM29_RS00285	COG1214	PFAM Peptidase M22, glycoprotease
BTM29_RS00305	COG4467	Involved in initiation control of chromosome replication
BTM29_RS00310	COG0470	DNA polymerase III
BTM29_RS00315	COG3870	Protein conserved in bacteria
BTM29_RS00320	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BTM29_RS00340	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BTM29_RS00350	COG0590	tRNA wobble adenosine to inosine editing
BTM29_RS00355	COG2813	Specifically methylates the guanine in position
BTM29_RS00360	COG0222	ribosome binding
BTM29_RS00370	COG0081	regulation of translation
BTM29_RS00375	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BTM29_RS00380	COG0250	Participates in transcription elongation, termination and antitermination
BTM29_RS00390	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BTM29_RS00405	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
BTM29_RS00410	COG0215	cysteine-tRNA ligase activity
BTM29_RS00415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BTM29_RS00420	COG4956	integral membrane protein (PIN domain superfamily)
BTM29_RS00425	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BTM29_RS00430	COG0756	dUTP diphosphatase activity
BTM29_RS00440	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BTM29_RS00450	COG2936	dipeptidyl-peptidase activity
BTM29_RS00460	COG0588	phosphoglycerate mutase activity
BTM29_RS00490	COG3716	PTS system mannose fructose sorbose family IID component
BTM29_RS00495	COG3715	PTS system
BTM29_RS00520	COG1263	PTS System
BTM29_RS00520	COG2190	(PTS) system
BTM29_RS00520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BTM29_RS00525	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BTM29_RS00540	COG0745	RESPONSE REGULATOR receiver
BTM29_RS00550	COG0573	inorganic phosphate transmembrane transporter activity
BTM29_RS00555	COG0581	inorganic phosphate transmembrane transporter activity
BTM29_RS00570	COG0028	Belongs to the TPP enzyme family
BTM29_RS00575	COG1396	sequence-specific DNA binding
BTM29_RS00605	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BTM29_RS00610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BTM29_RS00615	COG3639	organic phosphonate transmembrane transporter activity
BTM29_RS00620	COG3639	organic phosphonate transmembrane transporter activity
BTM29_RS00625	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BTM29_RS00640	COG1288	antiporter activity
BTM29_RS00655	COG1132	(ABC) transporter
BTM29_RS00660	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BTM29_RS00665	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BTM29_RS00670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BTM29_RS00680	COG2135	peptidase activity
BTM29_RS00690	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BTM29_RS00695	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BTM29_RS00700	COG0101	tRNA pseudouridine synthase activity
BTM29_RS00720	COG0203	ribosomal protein L17
BTM29_RS00735	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BTM29_RS00740	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BTM29_RS00745	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BTM29_RS00750	COG0563	adenylate kinase activity
BTM29_RS00760	COG0200	Binds to the 23S rRNA
BTM29_RS00770	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BTM29_RS00775	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BTM29_RS00780	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BTM29_RS00795	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BTM29_RS00800	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BTM29_RS00805	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BTM29_RS00810	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BTM29_RS00815	COG0255	Belongs to the universal ribosomal protein uL29 family
BTM29_RS00820	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BTM29_RS00825	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BTM29_RS00835	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BTM29_RS00840	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BTM29_RS00845	COG0089	rRNA binding
BTM29_RS00850	COG0088	Forms part of the polypeptide exit tunnel
BTM29_RS00855	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BTM29_RS00860	COG0051	transcription antitermination factor activity, RNA binding
BTM29_RS00870	COG0049	tRNA binding
BTM29_RS00900	COG0542	response to heat
BTM29_RS00930	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BTM29_RS00935	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BTM29_RS00940	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BTM29_RS00950	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BTM29_RS00955	COG0037	tRNA processing
BTM29_RS00960	COG1098	S1 RNA binding domain
BTM29_RS00970	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BTM29_RS00975	COG2244	polysaccharide biosynthetic process
BTM29_RS00980	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BTM29_RS00985	COG0193	aminoacyl-tRNA hydrolase activity
BTM29_RS00990	COG0039	L-malate dehydrogenase activity
BTM29_RS01000	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BTM29_RS01015	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BTM29_RS01025	COG0254	rRNA binding
BTM29_RS01030	COG0488	(ABC) transporter
BTM29_RS01035	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BTM29_RS01040	COG0504	CTP synthase activity
BTM29_RS01045	COG3343	RNA polymerase activity
BTM29_RS01055	COG0095	Lipoate-protein ligase
BTM29_RS01060	COG1078	dGTPase activity
BTM29_RS01065	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BTM29_RS01080	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BTM29_RS01085	COG0471	metal ion transport
BTM29_RS01090	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BTM29_RS01095	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BTM29_RS01100	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BTM29_RS01105	COG4466	Protein conserved in bacteria
BTM29_RS01110	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BTM29_RS01115	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BTM29_RS01120	COG0084	hydrolase, TatD family'
BTM29_RS01125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BTM29_RS01125	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BTM29_RS01130	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BTM29_RS01145	COG0248	Ppx GppA phosphatase
BTM29_RS01150	COG0390	transport system, permease component
BTM29_RS01155	COG4619	ABC transporter
BTM29_RS01160	COG1902	pentaerythritol trinitrate reductase activity
BTM29_RS01180	COG2814	Major facilitator Superfamily
BTM29_RS01195	COG3973	AAA domain
BTM29_RS01255	COG1442	glycosyl transferase family 8
BTM29_RS01255	COG1216	Glycosyl transferase, family 2
BTM29_RS01300	COG0765	amino acid transport
BTM29_RS01305	COG1126	abc transporter atp-binding protein
BTM29_RS01310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTM29_RS01320	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BTM29_RS01330	COG0798	PFAM Bile acid sodium symporter
BTM29_RS01340	COG2807	transmembrane transport
BTM29_RS01345	COG2814	Major facilitator Superfamily
BTM29_RS01355	COG3682	Transcriptional regulator
BTM29_RS01360	COG2271	Major facilitator Superfamily
BTM29_RS01365	COG0066	3-isopropylmalate dehydratase activity
BTM29_RS01370	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BTM29_RS01375	COG0473	3-isopropylmalate dehydrogenase activity
BTM29_RS01405	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
BTM29_RS01410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BTM29_RS01415	COG1696	Membrane protein involved in D-alanine export
BTM29_RS01420	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BTM29_RS01435	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BTM29_RS01460	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BTM29_RS01460	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BTM29_RS01465	COG1737	Transcriptional regulator
BTM29_RS01475	COG2723	6-phospho-beta-galactosidase activity
BTM29_RS01480	COG1940	carbohydrate kinase activity
BTM29_RS01505	COG2188	Transcriptional regulator
BTM29_RS01510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BTM29_RS01510	COG2190	(PTS) system
BTM29_RS01510	COG1263	PTS System
BTM29_RS01515	COG2188	Transcriptional regulator
BTM29_RS01530	COG1132	(ABC) transporter
BTM29_RS01545	COG1307	EDD domain protein, DegV family
BTM29_RS01555	COG0697	spore germination
BTM29_RS01560	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BTM29_RS01585	COG3964	amidohydrolase
BTM29_RS01600	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BTM29_RS01605	COG2188	Transcriptional regulator
BTM29_RS01610	COG2217	Heavy metal translocating P-type atpase
BTM29_RS01625	COG1309	transcriptional regulator
BTM29_RS01645	COG0366	Alpha amylase catalytic
BTM29_RS01655	COG3716	PTS system mannose fructose sorbose family IID component
BTM29_RS01665	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BTM29_RS01670	COG1609	Transcriptional regulator
BTM29_RS01680	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BTM29_RS01680	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BTM29_RS01685	COG2723	6-phospho-beta-galactosidase activity
BTM29_RS01690	COG1447	Phosphotransferase system cellobiose-specific component IIA
BTM29_RS01695	COG3711	transcriptional antiterminator
BTM29_RS01700	COG1181	Belongs to the D-alanine--D-alanine ligase family
BTM29_RS01710	COG0328	RNA-DNA hybrid ribonuclease activity
BTM29_RS01730	COG2738	Putative neutral zinc metallopeptidase
BTM29_RS01735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BTM29_RS01745	COG0657	acetylesterase activity
BTM29_RS01770	COG1136	(ABC) transporter
BTM29_RS01770	COG0577	efflux transmembrane transporter activity
BTM29_RS01785	COG1309	transcriptional regulator
BTM29_RS01790	COG1131	(ABC) transporter
BTM29_RS01805	COG1914	H( )-stimulated, divalent metal cation uptake system
BTM29_RS01810	COG0861	Integral membrane protein TerC family
BTM29_RS01815	COG2207	Transcriptional regulator
BTM29_RS01820	COG3189	MarR family transcriptional regulator
BTM29_RS01850	COG1113	amino acid transport
BTM29_RS01855	COG1113	amino acid transport
BTM29_RS01865	COG1609	Transcriptional regulator
BTM29_RS01875	COG2226	methyltransferase
BTM29_RS01895	COG0656	L-ascorbic acid biosynthetic process
BTM29_RS01915	COG0697	spore germination
BTM29_RS01925	COG2233	PERMEase
BTM29_RS01935	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BTM29_RS01940	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BTM29_RS01945	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BTM29_RS01955	COG0477	Major facilitator Superfamily
BTM29_RS01965	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BTM29_RS01990	COG2723	6-phospho-beta-galactosidase activity
BTM29_RS02000	COG2207	Transcriptional regulator
BTM29_RS02015	COG3250	beta-galactosidase activity
BTM29_RS02020	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BTM29_RS02025	COG3457	Alanine racemase
BTM29_RS02030	COG0626	cystathionine gamma-synthase activity
BTM29_RS02035	COG1735	metal-dependent hydrolase with the TIM-barrel fold
BTM29_RS02055	COG2188	Transcriptional regulator
BTM29_RS02065	COG0383	alpha-mannosidase activity
BTM29_RS02075	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BTM29_RS02075	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BTM29_RS02080	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BTM29_RS02080	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BTM29_RS02080	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BTM29_RS02105	COG0366	Alpha amylase catalytic
BTM29_RS02130	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
BTM29_RS02135	COG1120	ATPase activity
BTM29_RS02140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BTM29_RS02145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BTM29_RS02160	COG1012	belongs to the aldehyde dehydrogenase family
BTM29_RS02165	COG0686	Belongs to the AlaDH PNT family
BTM29_RS02175	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BTM29_RS02185	COG2723	6-phospho-beta-galactosidase activity
BTM29_RS02195	COG2971	BadF BadG BcrA BcrD
BTM29_RS02200	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BTM29_RS02225	COG1733	regulation of RNA biosynthetic process
BTM29_RS02240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BTM29_RS02245	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BTM29_RS02260	COG5002	protein histidine kinase activity
BTM29_RS02265	COG0745	RESPONSE REGULATOR receiver
BTM29_RS02285	COG4989	oxidoreductase activity
BTM29_RS02295	COG1373	ATPase (AAA superfamily
BTM29_RS02300	COG3973	AAA domain
BTM29_RS02320	COG4120	Belongs to the binding-protein-dependent transport system permease family
BTM29_RS02330	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BTM29_RS02335	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BTM29_RS02340	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BTM29_RS02345	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BTM29_RS02350	COG0626	cystathionine gamma-synthase activity
BTM29_RS02355	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BTM29_RS02365	COG2814	Major facilitator Superfamily
BTM29_RS02375	COG1396	sequence-specific DNA binding
BTM29_RS02380	COG2814	Major facilitator Superfamily
BTM29_RS02390	COG0604	alcohol dehydrogenase
BTM29_RS02395	COG1113	amino acid transport
BTM29_RS02400	COG1113	amino acid transport
BTM29_RS02420	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BTM29_RS02425	COG0531	amino acid
BTM29_RS02435	COG1063	alcohol dehydrogenase
BTM29_RS02460	COG0517	IMP dehydrogenase activity
BTM29_RS02460	COG0516	GMP reductase activity
BTM29_RS02470	COG2076	Multidrug Resistance protein
BTM29_RS02490	COG3655	Transcriptional regulator
BTM29_RS02500	COG4716	Myosin-crossreactive antigen
BTM29_RS02510	COG2364	Membrane
BTM29_RS02515	COG3759	membrane
BTM29_RS02520	COG2244	polysaccharide biosynthetic process
BTM29_RS02545	COG1940	carbohydrate kinase activity
BTM29_RS02555	COG2246	polysaccharide biosynthetic process
BTM29_RS02570	COG0803	Belongs to the bacterial solute-binding protein 9 family
BTM29_RS02580	COG1794	racemase activity, acting on amino acids and derivatives
BTM29_RS02590	COG1686	Belongs to the peptidase S11 family
BTM29_RS02605	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BTM29_RS02610	COG2723	6-phospho-beta-galactosidase activity
BTM29_RS02615	COG2188	Transcriptional regulator
BTM29_RS02625	COG1473	amidohydrolase
BTM29_RS02635	COG0012	GTP binding
BTM29_RS02640	COG4481	Protein conserved in bacteria
BTM29_RS02645	COG1475	DNA binding
BTM29_RS02650	COG1192	Involved in chromosome partitioning
BTM29_RS02655	COG0357	Ribosomal RNA small subunit methyltransferase G
BTM29_RS02660	COG2153	protein acetylation
BTM29_RS02670	COG0789	Transcriptional regulator
BTM29_RS02685	COG3442	glutamine amidotransferase
BTM29_RS02700	COG3775	system Galactitol-specific IIC component
BTM29_RS02725	COG4684	Psort location CytoplasmicMembrane, score
BTM29_RS02735	COG2249	NAD(P)H dehydrogenase (quinone) activity
BTM29_RS02740	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BTM29_RS02755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BTM29_RS02760	COG0789	Transcriptional regulator
BTM29_RS02765	COG0351	phosphomethylpyrimidine kinase
BTM29_RS02775	COG1271	oxidase subunit
BTM29_RS02780	COG1294	oxidase, subunit
BTM29_RS02785	COG4988	ABC transporter
BTM29_RS02790	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BTM29_RS02795	COG0142	geranyltranstransferase activity
BTM29_RS02805	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BTM29_RS02815	COG0463	Glycosyl transferase, family 2
BTM29_RS02825	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BTM29_RS02855	COG3158	transport of potassium into the cell
BTM29_RS02860	COG1335	isochorismatase
BTM29_RS02865	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
BTM29_RS02870	COG1518	maintenance of DNA repeat elements
BTM29_RS02905	COG0531	amino acid
BTM29_RS02910	COG0673	inositol 2-dehydrogenase activity
BTM29_RS02920	COG0445	tRNA wobble uridine modification
BTM29_RS02925	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BTM29_RS02940	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BTM29_RS02945	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BTM29_RS02950	COG0592	DNA-directed DNA polymerase activity
BTM29_RS02955	COG2501	S4 domain
BTM29_RS02960	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BTM29_RS02965	COG0187	DNA topoisomerase II activity
BTM29_RS02970	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BTM29_RS02975	COG0360	Binds together with S18 to 16S ribosomal RNA
BTM29_RS02980	COG0629	single-stranded DNA binding
BTM29_RS02985	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BTM29_RS02995	COG0359	binds to the 23S rRNA
BTM29_RS03000	COG0305	Participates in initiation and elongation during chromosome replication
BTM29_RS03020	COG1846	Transcriptional regulator
BTM29_RS03035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BTM29_RS03045	COG0531	amino acid
BTM29_RS03060	COG1316	TRANSCRIPTIONal
BTM29_RS03065	COG0488	(ABC) transporter
BTM29_RS03090	COG2814	Major facilitator Superfamily
BTM29_RS03105	COG0730	response to heat
BTM29_RS03135	COG1136	(ABC) transporter
BTM29_RS03140	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BTM29_RS03145	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BTM29_RS03150	COG1780	Probably involved in ribonucleotide reductase function
BTM29_RS03155	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BTM29_RS03180	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BTM29_RS03205	COG3458	cephalosporin-C deacetylase activity
BTM29_RS03215	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BTM29_RS03220	COG0475	glutathione-regulated potassium exporter activity
BTM29_RS03230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BTM29_RS03235	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BTM29_RS03240	COG1737	Transcriptional regulator
BTM29_RS03255	COG2267	carboxylic ester hydrolase activity
BTM29_RS03260	COG2188	Transcriptional regulator
BTM29_RS03265	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BTM29_RS03275	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BTM29_RS03280	COG2971	BadF BadG BcrA BcrD
BTM29_RS03290	COG4608	Belongs to the ABC transporter superfamily
BTM29_RS03295	COG0444	Belongs to the ABC transporter superfamily
BTM29_RS03300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BTM29_RS03305	COG0601	transmembrane transport
BTM29_RS03310	COG4166	transmembrane transport
BTM29_RS03315	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BTM29_RS03320	COG3279	Response regulator of the LytR AlgR family
BTM29_RS03390	COG3290	protein histidine kinase activity
BTM29_RS03395	COG3279	Response regulator of the LytR AlgR family
BTM29_RS03405	COG0488	(ABC) transporter
BTM29_RS03425	COG0531	amino acid
BTM29_RS03430	COG1136	(ABC) transporter
BTM29_RS03445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTM29_RS03450	COG0765	amino acid transport
BTM29_RS03455	COG0765	amino acid transport
BTM29_RS03460	COG1757	Na H antiporter
BTM29_RS03470	COG1136	(ABC) transporter
BTM29_RS03475	COG0577	efflux transmembrane transporter activity
BTM29_RS03490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BTM29_RS03510	COG1288	antiporter activity
BTM29_RS03520	COG0477	Major facilitator Superfamily
BTM29_RS03525	COG0588	phosphoglycerate mutase activity
BTM29_RS03530	COG2910	NAD(P)H-binding
BTM29_RS03535	COG0716	FMN binding
BTM29_RS03540	COG0114	fumarate hydratase activity
BTM29_RS03550	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BTM29_RS03555	COG3715	PTS system
BTM29_RS03560	COG3716	PTS system mannose fructose sorbose family IID component
BTM29_RS03585	COG3684	Belongs to the aldolase LacD family
BTM29_RS03595	COG0698	ribose 5-phosphate isomerase
BTM29_RS03600	COG0698	ribose 5-phosphate isomerase
BTM29_RS03625	COG1121	(ABC) transporter
BTM29_RS03630	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BTM29_RS03645	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BTM29_RS03650	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BTM29_RS03660	COG0297	glycogen (starch) synthase activity
BTM29_RS03665	COG0058	SHG alpha-glucan phosphorylase activity
BTM29_RS03675	COG2267	carboxylic ester hydrolase activity
BTM29_RS03685	COG2608	mercury ion transmembrane transporter activity
BTM29_RS03695	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BTM29_RS03710	COG3973	AAA domain
BTM29_RS03715	COG1802	Transcriptional regulator
BTM29_RS03720	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BTM29_RS03730	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BTM29_RS03730	COG0473	3-isopropylmalate dehydrogenase activity
BTM29_RS03750	COG1072	(Pantothenic acid kinase))
BTM29_RS03755	COG0519	Catalyzes the synthesis of GMP from XMP
BTM29_RS03755	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BTM29_RS03775	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BTM29_RS03790	COG0789	Transcriptional regulator
BTM29_RS03800	COG0656	L-ascorbic acid biosynthetic process
BTM29_RS03805	COG0656	L-ascorbic acid biosynthetic process
BTM29_RS03810	COG4975	Glucose uptake
BTM29_RS03830	COG1063	alcohol dehydrogenase
BTM29_RS03835	COG0583	DNA-binding transcription factor activity
BTM29_RS03850	COG0667	Aldo Keto reductase
BTM29_RS03860	COG0308	aminopeptidase N
BTM29_RS03865	COG1695	Transcriptional regulator
BTM29_RS03870	COG3479	Phenolic acid decarboxylase
BTM29_RS03875	COG0670	Belongs to the BI1 family
BTM29_RS03890	COG0531	amino acid
BTM29_RS03895	COG0419	ATPase involved in DNA repair
BTM29_RS03900	COG0420	3'-5' exonuclease activity
BTM29_RS03910	COG3976	FMN-binding domain protein
BTM29_RS03910	COG1053	succinate dehydrogenase
BTM29_RS03910	COG0431	NADPH-dependent FMN reductase
BTM29_RS03920	COG2502	aspartate--ammonia ligase
BTM29_RS03925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BTM29_RS03925	COG5549	protein import
BTM29_RS03935	COG4690	dipeptidase activity
BTM29_RS03950	COG0583	DNA-binding transcription factor activity
BTM29_RS03960	COG3976	FMN-binding domain protein
BTM29_RS03960	COG1053	succinate dehydrogenase
BTM29_RS03960	COG0431	NADPH-dependent FMN reductase
BTM29_RS03980	COG0668	transmembrane transport
BTM29_RS03990	COG0431	NADPH-dependent FMN reductase
BTM29_RS04000	COG0667	Aldo Keto reductase
BTM29_RS04020	COG0778	Nitroreductase
BTM29_RS04040	COG1175	transmembrane transport
BTM29_RS04045	COG0395	ABC-type sugar transport system, permease component
BTM29_RS04050	COG3842	ATPase activity
BTM29_RS04060	COG1132	(ABC) transporter
BTM29_RS04065	COG1132	(ABC) transporter
BTM29_RS04070	COG0656	L-ascorbic acid biosynthetic process
BTM29_RS04110	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BTM29_RS04115	COG1914	H( )-stimulated, divalent metal cation uptake system
BTM29_RS04120	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BTM29_RS04125	COG0300	oxidoreductase activity
BTM29_RS04130	COG0735	belongs to the Fur family
BTM29_RS04140	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BTM29_RS04140	COG0574	Belongs to the PEP-utilizing enzyme family
BTM29_RS04155	COG0318	PFAM AMP-dependent synthetase and ligase
BTM29_RS04160	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BTM29_RS04175	COG1028	Short-chain dehydrogenase reductase Sdr
BTM29_RS04180	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BTM29_RS04195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BTM29_RS04205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BTM29_RS04205	COG1263	PTS System
BTM29_RS04215	COG2190	(PTS) system
BTM29_RS04215	COG1263	PTS System
BTM29_RS04215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BTM29_RS04220	COG1609	Transcriptional regulator
BTM29_RS04240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BTM29_RS04250	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BTM29_RS04255	COG0800	Aldolase
BTM29_RS04260	COG3964	amidohydrolase
BTM29_RS04300	COG0588	phosphoglycerate mutase activity
BTM29_RS04305	COG0583	DNA-binding transcription factor activity
BTM29_RS04315	COG2271	Major facilitator Superfamily
BTM29_RS04320	COG0738	Major facilitator superfamily
BTM29_RS04330	COG1028	Short-chain dehydrogenase reductase Sdr
BTM29_RS04335	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BTM29_RS04340	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BTM29_RS04345	COG2186	Transcriptional regulator
BTM29_RS04355	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BTM29_RS04355	COG1017	nitric oxide dioxygenase activity
BTM29_RS04365	COG1116	anion transmembrane transporter activity
BTM29_RS04370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BTM29_RS04375	COG0318	PFAM AMP-dependent synthetase and ligase
BTM29_RS04390	COG5002	protein histidine kinase activity
BTM29_RS04395	COG0745	RESPONSE REGULATOR receiver
BTM29_RS04400	COG0735	belongs to the Fur family
BTM29_RS04415	COG0500	methyltransferase
BTM29_RS04420	COG1937	Protein conserved in bacteria
BTM29_RS04425	COG3118	belongs to the thioredoxin family
BTM29_RS04435	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BTM29_RS04445	COG2188	Transcriptional regulator
BTM29_RS04450	COG2723	6-phospho-beta-galactosidase activity
BTM29_RS04455	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BTM29_RS04460	COG1297	OPT oligopeptide transporter protein
BTM29_RS04475	COG3706	GGDEF domain
BTM29_RS04480	COG1760	l-serine dehydratase
BTM29_RS04485	COG1760	l-serine dehydratase
BTM29_RS04525	COG1373	ATPase (AAA superfamily
BTM29_RS04535	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
BTM29_RS04540	COG2188	Transcriptional regulator
BTM29_RS04545	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
BTM29_RS04555	COG2365	Tyrosine phosphatase family
BTM29_RS04570	COG0519	Catalyzes the synthesis of GMP from XMP
BTM29_RS04580	COG1121	(ABC) transporter
BTM29_RS04600	COG0367	asparagine synthase
BTM29_RS04615	COG3590	peptidase
BTM29_RS04630	COG0789	Transcriptional regulator
BTM29_RS04645	COG4221	oxidoreductase activity
BTM29_RS04655	COG4152	abc transporter atp-binding protein
BTM29_RS04660	COG1668	transmembrane transport
BTM29_RS04665	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BTM29_RS04670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BTM29_RS04680	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BTM29_RS04685	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BTM29_RS04705	COG0505	Belongs to the CarA family
BTM29_RS04710	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BTM29_RS04720	COG1073	alpha beta
BTM29_RS04740	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BTM29_RS04755	COG0028	Belongs to the TPP enzyme family
BTM29_RS04765	COG0531	amino acid
BTM29_RS04860	COG1705	Flagellar rod assembly protein muramidase FlgJ
BTM29_RS04860	COG1388	LysM domain
BTM29_RS04890	COG0628	permease
BTM29_RS04900	COG0588	phosphoglycerate mutase activity
BTM29_RS04920	COG1725	Transcriptional regulator
BTM29_RS04925	COG1131	(ABC) transporter
BTM29_RS04935	COG0386	Belongs to the glutathione peroxidase family
BTM29_RS04950	COG3527	Alpha-acetolactate decarboxylase
BTM29_RS04955	COG0028	Belongs to the TPP enzyme family
BTM29_RS04970	COG0242	peptide deformylase activity
BTM29_RS04975	COG1442	glycosyl transferase family 8
BTM29_RS04990	COG0489	protein tyrosine kinase activity
BTM29_RS04995	COG4464	protein tyrosine phosphatase activity
BTM29_RS05000	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BTM29_RS05020	COG0438	transferase activity, transferring glycosyl groups
BTM29_RS05045	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BTM29_RS05055	COG0110	maltose O-acetyltransferase activity
BTM29_RS05060	COG1088	dTDP-glucose 4,6-dehydratase activity
BTM29_RS05065	COG1091	dTDP-4-dehydrorhamnose reductase activity
BTM29_RS05075	COG1316	TRANSCRIPTIONal
BTM29_RS05120	COG0489	protein tyrosine kinase activity
BTM29_RS05125	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BTM29_RS05135	COG0438	transferase activity, transferring glycosyl groups
BTM29_RS05155	COG0562	UDP-galactopyranose mutase
BTM29_RS05160	COG2244	polysaccharide biosynthetic process
BTM29_RS05165	COG2188	Transcriptional regulator
BTM29_RS05170	COG2188	Transcriptional regulator
BTM29_RS05175	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BTM29_RS05175	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BTM29_RS05180	COG3715	PTS system
BTM29_RS05185	COG3716	PTS system mannose fructose sorbose family IID component
BTM29_RS05200	COG2222	sugar isomerase
BTM29_RS05210	COG0584	glycerophosphoryl diester phosphodiesterase
BTM29_RS05235	COG2365	Tyrosine phosphatase family
BTM29_RS05255	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BTM29_RS05260	COG2723	6-phospho-beta-galactosidase activity
BTM29_RS05270	COG0719	Fe-S assembly protein
BTM29_RS05275	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BTM29_RS05285	COG0719	Fe-S assembly protein
BTM29_RS05295	COG3041	Addiction module toxin RelE StbE family
BTM29_RS05300	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BTM29_RS05320	COG1253	flavin adenine dinucleotide binding
BTM29_RS05330	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BTM29_RS05335	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BTM29_RS05340	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BTM29_RS05355	COG2084	Dehydrogenase
BTM29_RS05360	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BTM29_RS05365	COG0702	epimerase
BTM29_RS05375	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BTM29_RS05395	COG0519	Catalyzes the synthesis of GMP from XMP
BTM29_RS05435	COG0833	amino acid
BTM29_RS05440	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BTM29_RS05455	COG4974	Belongs to the 'phage' integrase family
BTM29_RS05465	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BTM29_RS05520	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
BTM29_RS05535	COG0629	single-stranded DNA binding
BTM29_RS05540	COG0863	Belongs to the N(4) N(6)-methyltransferase family
BTM29_RS05555	COG0270	DNA (cytosine-5-)-methyltransferase activity
BTM29_RS05595	COG1475	DNA binding
BTM29_RS05700	COG5280	Phage tail tape measure protein TP901
BTM29_RS05700	COG3953	SLT domain
BTM29_RS05765	COG5263	repeat protein
BTM29_RS05765	COG5632	N-Acetylmuramoyl-L-alanine amidase
BTM29_RS05780	COG0667	Aldo Keto reductase
BTM29_RS05785	COG0446	pyridine nucleotide-disulphide oxidoreductase
BTM29_RS05795	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BTM29_RS05800	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BTM29_RS05805	COG3104	oligopeptide transport
BTM29_RS05820	COG2188	Transcriptional regulator
BTM29_RS05835	COG0438	transferase activity, transferring glycosyl groups
BTM29_RS05840	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BTM29_RS05850	COG0436	Aminotransferase
BTM29_RS05860	COG0463	Glycosyl transferase, family 2
BTM29_RS05900	COG1869	D-ribose catabolic process
BTM29_RS05910	COG1278	Cold shock
BTM29_RS05915	COG2814	Major facilitator Superfamily
BTM29_RS05920	COG1705	Flagellar rod assembly protein muramidase FlgJ
BTM29_RS05930	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BTM29_RS05935	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BTM29_RS05945	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BTM29_RS05950	COG4851	CamS sex pheromone cAM373 precursor
BTM29_RS05955	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BTM29_RS05960	COG0154	amidase activity
BTM29_RS05965	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BTM29_RS05970	COG1597	lipid kinase activity
BTM29_RS05975	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BTM29_RS06010	COG0531	amino acid
BTM29_RS06015	COG0673	inositol 2-dehydrogenase activity
BTM29_RS06040	COG1607	acyl-coa hydrolase
BTM29_RS06050	COG2323	membrane
BTM29_RS06075	COG2199	diguanylate cyclase activity
BTM29_RS06085	COG0446	pyridine nucleotide-disulphide oxidoreductase
BTM29_RS06105	COG2153	protein acetylation
BTM29_RS06110	COG0446	pyridine nucleotide-disulphide oxidoreductase
BTM29_RS06125	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BTM29_RS06140	COG0716	FMN binding
BTM29_RS06145	COG0024	Methionine aminopeptidase
BTM29_RS06150	COG1295	ribonuclease BN
BTM29_RS06155	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BTM29_RS06165	COG0183	Belongs to the thiolase family
BTM29_RS06175	COG3425	synthase
BTM29_RS06200	COG2897	thiosulfate sulfurtransferase activity
BTM29_RS06210	COG0398	Pfam SNARE associated Golgi protein
BTM29_RS06215	COG0398	Pfam SNARE associated Golgi protein
BTM29_RS06220	COG4134	Bacterial extracellular solute-binding protein
BTM29_RS06235	COG3842	ATPase activity
BTM29_RS06275	COG3104	oligopeptide transport
BTM29_RS06280	COG0006	proline dipeptidase activity
BTM29_RS06285	COG4690	dipeptidase activity
BTM29_RS06290	COG0701	Predicted permease
BTM29_RS06295	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BTM29_RS06300	COG4656	Part of a membrane complex involved in electron transport
BTM29_RS06305	COG5275	peptidyl-tyrosine sulfation
BTM29_RS06305	COG0252	asparaginase activity
BTM29_RS06320	COG5275	peptidyl-tyrosine sulfation
BTM29_RS06320	COG0252	asparaginase activity
BTM29_RS06325	COG5275	peptidyl-tyrosine sulfation
BTM29_RS06325	COG0252	asparaginase activity
BTM29_RS06340	COG0709	Synthesizes selenophosphate from selenide and ATP
BTM29_RS06360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BTM29_RS06370	COG0446	pyridine nucleotide-disulphide oxidoreductase
BTM29_RS06375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BTM29_RS06380	COG4521	taurine ABC transporter
BTM29_RS06385	COG1116	anion transmembrane transporter activity
BTM29_RS06405	COG2217	Heavy metal translocating P-type atpase
BTM29_RS06415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BTM29_RS06420	COG1609	Transcriptional regulator
BTM29_RS06425	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
BTM29_RS06430	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BTM29_RS06435	COG1307	EDD domain protein, DegV family
BTM29_RS06450	COG0789	Transcriptional regulator
BTM29_RS06455	COG2814	Major facilitator Superfamily
BTM29_RS06465	COG0667	Aldo Keto reductase
BTM29_RS06480	COG0667	Aldo Keto reductase
BTM29_RS06485	COG0583	DNA-binding transcription factor activity
BTM29_RS06495	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BTM29_RS06500	COG2137	regulation of response to DNA damage stimulus
BTM29_RS06505	COG3557	Belongs to the UPF0374 family
BTM29_RS06510	COG1126	abc transporter atp-binding protein
BTM29_RS06515	COG0765	amino acid transport
BTM29_RS06520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTM29_RS06525	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BTM29_RS06540	COG1253	flavin adenine dinucleotide binding
BTM29_RS06545	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BTM29_RS06550	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
BTM29_RS06555	COG1114	Component of the transport system for branched-chain amino acids
BTM29_RS06560	COG0656	L-ascorbic acid biosynthetic process
BTM29_RS06565	COG3835	regulator
BTM29_RS06570	COG2610	gluconate transmembrane transporter activity
BTM29_RS06575	COG1929	Belongs to the glycerate kinase type-1 family
BTM29_RS06580	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BTM29_RS06585	COG0110	maltose O-acetyltransferase activity
BTM29_RS06595	COG0561	phosphatase activity
BTM29_RS06605	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BTM29_RS06610	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BTM29_RS06615	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BTM29_RS06620	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BTM29_RS06625	COG0131	Imidazoleglycerol-phosphate dehydratase
BTM29_RS06630	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BTM29_RS06635	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BTM29_RS06640	COG0107	imidazoleglycerol-phosphate synthase activity
BTM29_RS06645	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BTM29_RS06650	COG0140	phosphoribosyl-ATP diphosphatase activity
BTM29_RS06655	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BTM29_RS06670	COG0542	response to heat
BTM29_RS06675	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BTM29_RS06690	COG1114	Component of the transport system for branched-chain amino acids
BTM29_RS06695	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BTM29_RS06705	COG1175	transmembrane transport
BTM29_RS06715	COG1653	transport
BTM29_RS06730	COG2205	protein histidine kinase activity
BTM29_RS06735	COG0745	RESPONSE REGULATOR receiver
BTM29_RS06740	COG1136	(ABC) transporter
BTM29_RS06755	COG1234	tRNA 3'-trailer cleavage
BTM29_RS06760	COG1393	Belongs to the ArsC family
BTM29_RS06770	COG4862	establishment of competence for transformation
BTM29_RS06800	COG2357	RelA SpoT domain protein
BTM29_RS06805	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BTM29_RS06810	COG0564	pseudouridine synthase activity
BTM29_RS06815	COG2239	Acts as a magnesium transporter
BTM29_RS06820	COG3142	Participates in the control of copper homeostasis
BTM29_RS06830	COG2706	6-phosphogluconolactonase activity
BTM29_RS06835	COG0628	permease
BTM29_RS06850	COG1674	ftsk spoiiie
BTM29_RS06855	COG0612	Peptidase, M16
BTM29_RS06860	COG0612	Peptidase, M16
BTM29_RS06865	COG1028	Short-chain dehydrogenase reductase Sdr
BTM29_RS06870	COG1426	Protein conserved in bacteria
BTM29_RS06875	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BTM29_RS06895	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BTM29_RS06900	COG1739	Uncharacterized protein family UPF0029
BTM29_RS06905	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BTM29_RS06920	COG0653	protein targeting
BTM29_RS06925	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BTM29_RS06930	COG0745	RESPONSE REGULATOR receiver
BTM29_RS06935	COG5002	protein histidine kinase activity
BTM29_RS06940	COG1705	Flagellar rod assembly protein muramidase FlgJ
BTM29_RS06940	COG1388	LysM domain
BTM29_RS06950	COG0573	inorganic phosphate transmembrane transporter activity
BTM29_RS06955	COG0581	inorganic phosphate transmembrane transporter activity
BTM29_RS06960	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BTM29_RS06965	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BTM29_RS06970	COG0704	Plays a role in the regulation of phosphate uptake
BTM29_RS06980	COG1950	PFAM Membrane protein of
BTM29_RS06990	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BTM29_RS06995	COG0492	ferredoxin-NADP+ reductase activity
BTM29_RS07005	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BTM29_RS07015	COG2270	Major facilitator Superfamily
BTM29_RS07025	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BTM29_RS07030	COG1660	Displays ATPase and GTPase activities
BTM29_RS07040	COG1481	regulation of sporulation
BTM29_RS07050	COG1131	(ABC) transporter
BTM29_RS07060	COG2814	Major facilitator Superfamily
BTM29_RS07065	COG0740	serine-type endopeptidase activity
BTM29_RS07075	COG0583	DNA-binding transcription factor activity
BTM29_RS07080	COG2070	2-Nitropropane dioxygenase
BTM29_RS07080	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BTM29_RS07095	COG3052	prosthetic group binding
BTM29_RS07135	COG0159	tryptophan synthase activity
BTM29_RS07140	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
BTM29_RS07160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BTM29_RS07160	COG1263	PTS System
BTM29_RS07170	COG1737	Transcriptional regulator
BTM29_RS07180	COG2390	Transcriptional regulator
BTM29_RS07190	COG0126	phosphoglycerate kinase activity
BTM29_RS07200	COG0148	phosphopyruvate hydratase activity
BTM29_RS07210	COG0673	inositol 2-dehydrogenase activity
BTM29_RS07230	COG0557	exoribonuclease II activity
BTM29_RS07250	COG0561	phosphatase activity
BTM29_RS07255	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BTM29_RS07260	COG0280	phosphate acetyltransferase
BTM29_RS07265	COG0802	atpase or kinase
BTM29_RS07280	COG0708	Exodeoxyribonuclease III
BTM29_RS07285	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BTM29_RS07310	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BTM29_RS07315	COG0531	amino acid
BTM29_RS07325	COG0217	transcriptional regulatory protein
BTM29_RS07330	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BTM29_RS07335	COG1459	type II secretion system
BTM29_RS07340	COG4537	Required for transformation and DNA binding
BTM29_RS07365	COG0827	DNA restriction-modification system
BTM29_RS07370	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BTM29_RS07380	COG1454	alcohol dehydrogenase
BTM29_RS07380	COG1012	belongs to the aldehyde dehydrogenase family
BTM29_RS07385	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BTM29_RS07390	COG2252	PERMEase
BTM29_RS07395	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BTM29_RS07400	COG0584	glycerophosphoryl diester phosphodiesterase
BTM29_RS07410	COG1428	Deoxynucleoside kinase
BTM29_RS07415	COG4708	membrane
BTM29_RS07420	COG0438	transferase activity, transferring glycosyl groups
BTM29_RS07425	COG0438	transferase activity, transferring glycosyl groups
BTM29_RS07435	COG1368	sulfuric ester hydrolase activity
BTM29_RS07485	COG0527	aspartate kinase activity
BTM29_RS07490	COG0019	diaminopimelate decarboxylase activity
BTM29_RS07495	COG2171	N-acyltransferase activity
BTM29_RS07500	COG1473	amidohydrolase
BTM29_RS07505	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BTM29_RS07515	COG0436	Aminotransferase
BTM29_RS07520	COG0436	Aminotransferase
BTM29_RS07525	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BTM29_RS07545	COG1136	(ABC) transporter
BTM29_RS07560	COG1328	CTP reductase activity
BTM29_RS07570	COG2217	Heavy metal translocating P-type atpase
BTM29_RS07575	COG2094	Belongs to the DNA glycosylase MPG family
BTM29_RS07605	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BTM29_RS07610	COG0477	Major facilitator Superfamily
BTM29_RS07615	COG0671	phosphoesterase, PA-phosphatase related
BTM29_RS07620	COG1388	LysM domain
BTM29_RS07620	COG1705	Flagellar rod assembly protein muramidase FlgJ
BTM29_RS07630	COG2244	polysaccharide biosynthetic process
BTM29_RS07635	COG0583	DNA-binding transcription factor activity
BTM29_RS07645	COG1053	succinate dehydrogenase
BTM29_RS07645	COG3976	FMN-binding domain protein
BTM29_RS07650	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BTM29_RS07660	COG0789	Transcriptional regulator
BTM29_RS07665	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BTM29_RS07670	COG1970	mechanosensitive ion channel activity
BTM29_RS07675	COG0025	NhaP-type Na H and K H
BTM29_RS07680	COG1114	Component of the transport system for branched-chain amino acids
BTM29_RS07685	COG0137	argininosuccinate synthase activity
BTM29_RS07710	COG5002	protein histidine kinase activity
BTM29_RS07715	COG0745	RESPONSE REGULATOR receiver
BTM29_RS07720	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BTM29_RS07725	COG0463	Glycosyl transferase, family 2
BTM29_RS07730	COG0516	GMP reductase activity
BTM29_RS07740	COG1368	sulfuric ester hydrolase activity
BTM29_RS07755	COG0561	phosphatase activity
BTM29_RS07760	COG0582	viral genome integration into host DNA
BTM29_RS07785	COG3617	BRO family, N-terminal domain
BTM29_RS07820	COG1061	Type III restriction enzyme res subunit
BTM29_RS08070	COG1278	Cold shock
BTM29_RS08075	COG2235	arginine
BTM29_RS08080	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BTM29_RS08090	COG0018	arginyl-trna synthetase
BTM29_RS08100	COG0564	pseudouridine synthase activity
BTM29_RS08105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BTM29_RS08115	COG0420	3'-5' exonuclease activity
BTM29_RS08120	COG4717	serine-type aminopeptidase activity
BTM29_RS08125	COG3481	metal-dependent phosphohydrolase, HD sub domain
BTM29_RS08130	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BTM29_RS08140	COG0537	adenosine 5'-monophosphoramidase activity
BTM29_RS08145	COG1131	(ABC) transporter
BTM29_RS08155	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BTM29_RS08165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BTM29_RS08170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BTM29_RS08175	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BTM29_RS08180	COG2814	Major facilitator Superfamily
BTM29_RS08185	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BTM29_RS08185	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BTM29_RS08195	COG0237	dephospho-CoA kinase activity
BTM29_RS08205	COG3611	Membrane attachment protein
BTM29_RS08210	COG1484	DNA-dependent DNA replication
BTM29_RS08220	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BTM29_RS08240	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BTM29_RS08250	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BTM29_RS08255	COG1713	HD superfamily hydrolase involved in NAD metabolism
BTM29_RS08260	COG0799	negative regulation of ribosome biogenesis
BTM29_RS08265	COG2226	methyltransferase
BTM29_RS08270	COG1323	Belongs to the UPF0348 family
BTM29_RS08280	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BTM29_RS08285	COG0745	RESPONSE REGULATOR receiver
BTM29_RS08290	COG5002	protein histidine kinase activity
BTM29_RS08295	COG0706	membrane insertase activity
BTM29_RS08305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BTM29_RS08315	COG0072	phenylalanine-tRNA ligase activity
BTM29_RS08320	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BTM29_RS08325	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BTM29_RS08330	COG4841	protein insertion into membrane
BTM29_RS08335	COG0768	penicillin binding
BTM29_RS08340	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BTM29_RS08345	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BTM29_RS08350	COG0705	Rhomboid family
BTM29_RS08350	COG0457	Tetratricopeptide repeat
BTM29_RS08360	COG1940	carbohydrate kinase activity
BTM29_RS08365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BTM29_RS08375	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BTM29_RS08380	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BTM29_RS08410	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BTM29_RS08420	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BTM29_RS08425	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BTM29_RS08435	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BTM29_RS08440	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BTM29_RS08445	COG1570	exodeoxyribonuclease VII activity
BTM29_RS08450	COG1722	exodeoxyribonuclease VII activity
BTM29_RS08460	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BTM29_RS08465	COG0497	DNA recombination
BTM29_RS08475	COG0194	GDP metabolic process
BTM29_RS08485	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BTM29_RS08490	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BTM29_RS08495	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BTM29_RS08495	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BTM29_RS08500	COG0631	protein serine/threonine phosphatase activity
BTM29_RS08505	COG2815	serine threonine protein kinase
BTM29_RS08505	COG0515	serine threonine protein kinase
BTM29_RS08510	COG1162	GTPase activity
BTM29_RS08515	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BTM29_RS08525	COG0778	Nitroreductase
BTM29_RS08530	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BTM29_RS08535	COG1302	Protein conserved in bacteria
BTM29_RS08545	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BTM29_RS08550	COG0416	fatty acid biosynthetic process
BTM29_RS08555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BTM29_RS08560	COG0571	ribonuclease III activity
BTM29_RS08565	COG1196	nuclear chromosome segregation
BTM29_RS08570	COG0552	protein localization to endoplasmic reticulum
BTM29_RS08575	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BTM29_RS08580	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BTM29_RS08585	COG0228	four-way junction DNA binding
BTM29_RS08590	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BTM29_RS08595	COG0336	Belongs to the RNA methyltransferase TrmD family
BTM29_RS08610	COG4224	UPF0291 protein
BTM29_RS08615	COG3763	UPF0154 protein
BTM29_RS08620	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BTM29_RS08625	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BTM29_RS08630	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BTM29_RS08635	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BTM29_RS08640	COG0047	phosphoribosylformylglycinamidine synthase activity
BTM29_RS08645	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BTM29_RS08655	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BTM29_RS08660	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BTM29_RS08665	COG0138	bifunctional purine biosynthesis protein purh
BTM29_RS08670	COG0151	Belongs to the GarS family
BTM29_RS08675	COG0204	Acyl-transferase
BTM29_RS08680	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BTM29_RS08685	COG2827	Endonuclease containing a URI domain
BTM29_RS08690	COG0052	Belongs to the universal ribosomal protein uS2 family
BTM29_RS08710	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BTM29_RS08715	COG4589	Belongs to the CDS family
BTM29_RS08720	COG0750	zinc metalloprotease
BTM29_RS08725	COG0442	prolyl-tRNA aminoacylation
BTM29_RS08730	COG2176	DNA-directed DNA polymerase activity
BTM29_RS08735	COG0779	Required for maturation of 30S ribosomal subunits
BTM29_RS08740	COG0195	Participates in both transcription termination and antitermination
BTM29_RS08745	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BTM29_RS08755	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BTM29_RS08760	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BTM29_RS08765	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BTM29_RS08770	COG0196	riboflavin kinase activity
BTM29_RS08775	COG1420	regulation of RNA biosynthetic process
BTM29_RS08780	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BTM29_RS08785	COG0443	Heat shock 70 kDa protein
BTM29_RS08790	COG0484	heat shock protein binding
BTM29_RS08800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BTM29_RS08830	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BTM29_RS08840	COG2197	response regulator
BTM29_RS08860	COG0315	cyclic pyranopterin monophosphate synthase activity
BTM29_RS08880	COG0719	Fe-S assembly protein
BTM29_RS08890	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BTM29_RS08915	COG0521	Mo-molybdopterin cofactor biosynthetic process
BTM29_RS08920	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BTM29_RS08925	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
BTM29_RS08930	COG1140	nitrate reductase beta subunit
BTM29_RS08940	COG2181	nitrate reductase activity
BTM29_RS08945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BTM29_RS08950	COG1120	ATPase activity
BTM29_RS08970	COG2223	nitrite transmembrane transporter activity
BTM29_RS08975	COG2151	metal-sulfur cluster biosynthetic enzyme
BTM29_RS08980	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BTM29_RS08985	COG0656	L-ascorbic acid biosynthetic process
BTM29_RS08990	COG0628	permease
BTM29_RS08995	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BTM29_RS09000	COG3764	Sortase (surface protein transpeptidase)
BTM29_RS09005	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BTM29_RS09005	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BTM29_RS09010	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BTM29_RS09100	COG0629	single-stranded DNA binding
BTM29_RS09135	COG5484	DNA packaging
BTM29_RS09230	COG3299	homolog of phage Mu protein gp47
BTM29_RS09290	COG1846	Transcriptional regulator
BTM29_RS09315	COG0589	response to stress
BTM29_RS09325	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BTM29_RS09330	COG1418	mRNA catabolic process
BTM29_RS09335	COG0450	alkyl hydroperoxide reductase
BTM29_RS09365	COG1304	FMN binding
BTM29_RS09370	COG1215	transferase activity, transferring glycosyl groups
BTM29_RS09380	COG1609	Transcriptional regulator
BTM29_RS09385	COG0366	Alpha amylase catalytic
BTM29_RS09390	COG0366	Alpha amylase catalytic
BTM29_RS09395	COG1653	transport
BTM29_RS09400	COG1175	transmembrane transport
BTM29_RS09405	COG3833	ABC-type maltose transport systems, permease component
BTM29_RS09410	COG0366	Alpha amylase catalytic
BTM29_RS09415	COG0366	Alpha amylase catalytic
BTM29_RS09420	COG0366	Alpha amylase catalytic
BTM29_RS09425	COG3842	ATPase activity
BTM29_RS09435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BTM29_RS09440	COG2017	converts alpha-aldose to the beta-anomer
BTM29_RS09445	COG0346	lactoylglutathione lyase activity
BTM29_RS09470	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BTM29_RS09485	COG2264	protein methyltransferase activity
BTM29_RS09490	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BTM29_RS09500	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BTM29_RS09505	COG1490	D-aminoacyl-tRNA deacylase activity
BTM29_RS09510	COG0546	phosphoglycolate phosphatase activity
BTM29_RS09520	COG0124	histidyl-tRNA synthetase
BTM29_RS09535	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BTM29_RS09540	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BTM29_RS09545	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BTM29_RS09550	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BTM29_RS09555	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BTM29_RS09560	COG1702	phosphate starvation-inducible protein PhoH
BTM29_RS09570	COG0295	cytidine deaminase activity
BTM29_RS09590	COG0751	glycine-tRNA ligase activity
BTM29_RS09595	COG0358	DNA primase activity
BTM29_RS09600	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BTM29_RS09605	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BTM29_RS09610	COG2384	SAM-dependent methyltransferase
BTM29_RS09615	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BTM29_RS09620	COG2195	Cleaves the N-terminal amino acid of tripeptides
BTM29_RS09625	COG4990	cell redox homeostasis
BTM29_RS09635	COG1942	4-Oxalocrotonate Tautomerase
BTM29_RS09660	COG0681	Belongs to the peptidase S26 family
BTM29_RS09675	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
BTM29_RS09675	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BTM29_RS09680	COG1304	FMN binding
BTM29_RS09695	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BTM29_RS09700	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BTM29_RS09710	COG1199	ATP-dependent helicase activity
BTM29_RS09710	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BTM29_RS09720	COG0017	Asparaginyl-tRNA synthetase
BTM29_RS09730	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BTM29_RS09735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BTM29_RS09740	COG3331	DNA recombination
BTM29_RS09760	COG0116	Belongs to the methyltransferase superfamily
BTM29_RS09770	COG0095	Lipoate-protein ligase
BTM29_RS09775	COG0328	RNA-DNA hybrid ribonuclease activity
BTM29_RS09785	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BTM29_RS09790	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BTM29_RS09795	COG0564	pseudouridine synthase activity
BTM29_RS09800	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BTM29_RS09805	COG0505	Belongs to the CarA family
BTM29_RS09820	COG1307	EDD domain protein, DegV family
BTM29_RS09835	COG0514	ATP-dependent DNA helicase (RecQ)
BTM29_RS09845	COG0561	phosphatase activity
BTM29_RS09850	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BTM29_RS09855	COG2169	Transcriptional regulator
BTM29_RS09865	COG2190	(PTS) system
BTM29_RS09865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BTM29_RS09865	COG1263	PTS System
BTM29_RS09890	COG4975	Glucose uptake
BTM29_RS09910	COG0187	DNA topoisomerase II activity
BTM29_RS10095	COG0629	single-stranded DNA binding
BTM29_RS10100	COG3646	Phage regulatory protein
BTM29_RS10140	COG1396	sequence-specific DNA binding
BTM29_RS10185	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BTM29_RS10200	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BTM29_RS10205	COG0758	DNA mediated transformation
BTM29_RS10210	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BTM29_RS10215	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BTM29_RS10220	COG4479	Belongs to the UPF0346 family
BTM29_RS10225	COG4698	Protein conserved in bacteria
BTM29_RS10230	COG2755	lipolytic protein G-D-S-L family
BTM29_RS10235	COG1307	EDD domain protein, DegV family
BTM29_RS10240	COG1272	protein, Hemolysin III
BTM29_RS10250	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BTM29_RS10255	COG0488	(ABC) transporter
BTM29_RS10270	COG0457	Tetratricopeptide repeat
BTM29_RS10280	COG1160	GTP binding
BTM29_RS10285	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BTM29_RS10295	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
BTM29_RS10300	COG1187	pseudouridine synthase activity
BTM29_RS10310	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BTM29_RS10325	COG2996	Protein conserved in bacteria
BTM29_RS10335	COG1131	(ABC) transporter
BTM29_RS10345	COG4585	Histidine kinase
BTM29_RS10350	COG2197	response regulator
BTM29_RS10365	COG0205	6-phosphofructokinase activity
BTM29_RS10370	COG0587	DNA-directed DNA polymerase activity
BTM29_RS10395	COG0300	oxidoreductase activity
BTM29_RS10400	COG1234	tRNA 3'-trailer cleavage
BTM29_RS10405	COG2755	lipolytic protein G-D-S-L family
BTM29_RS10405	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BTM29_RS10410	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BTM29_RS10415	COG1349	DNA-binding transcription factor activity
BTM29_RS10420	COG1105	Belongs to the carbohydrate kinase PfkB family
BTM29_RS10425	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BTM29_RS10425	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BTM29_RS10425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BTM29_RS10430	COG0322	excinuclease ABC activity
BTM29_RS10445	COG1285	pathogenesis
BTM29_RS10450	COG1285	pathogenesis
BTM29_RS10455	COG3716	PTS system mannose fructose sorbose family IID component
BTM29_RS10475	COG3933	PFAM sigma-54 factor interaction domain-containing protein
BTM29_RS10475	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BTM29_RS10490	COG0583	DNA-binding transcription factor activity
BTM29_RS10495	COG0281	malic enzyme
BTM29_RS10505	COG0561	phosphatase activity
BTM29_RS10525	COG0673	inositol 2-dehydrogenase activity
BTM29_RS10530	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BTM29_RS10535	COG0673	inositol 2-dehydrogenase activity
BTM29_RS10550	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BTM29_RS10555	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
BTM29_RS10560	COG1461	Dihydroxyacetone kinase
BTM29_RS10565	COG2376	Dihydroxyacetone kinase
BTM29_RS10570	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BTM29_RS10570	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BTM29_RS10575	COG1447	Phosphotransferase system cellobiose-specific component IIA
BTM29_RS10580	COG3711	transcriptional antiterminator
BTM29_RS10590	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BTM29_RS10590	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BTM29_RS10595	COG1447	Phosphotransferase system cellobiose-specific component IIA
BTM29_RS10600	COG3711	transcriptional antiterminator
BTM29_RS10605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BTM29_RS10610	COG1363	Peptidase, m42
BTM29_RS10615	COG1363	Peptidase, m42
BTM29_RS10625	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BTM29_RS10635	COG1446	asparaginase
BTM29_RS10640	COG0402	S-adenosylhomocysteine deaminase activity
BTM29_RS10660	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BTM29_RS10665	COG1737	Transcriptional regulator
BTM29_RS10670	COG2723	6-phospho-beta-galactosidase activity
BTM29_RS10675	COG2723	6-phospho-beta-galactosidase activity
BTM29_RS10680	COG1447	Phosphotransferase system cellobiose-specific component IIA
BTM29_RS10685	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BTM29_RS10690	COG0561	phosphatase activity
BTM29_RS10700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BTM29_RS10705	COG1288	antiporter activity
BTM29_RS10715	COG0446	pyridine nucleotide-disulphide oxidoreductase
BTM29_RS10740	COG1620	l-lactate permease
BTM29_RS10745	COG1620	l-lactate permease
BTM29_RS10750	COG0167	dihydroorotate dehydrogenase activity
BTM29_RS10760	COG0284	orotidine-5'-phosphate decarboxylase activity
BTM29_RS10770	COG0540	Belongs to the ATCase OTCase family
BTM29_RS10780	COG1757	Na H antiporter
BTM29_RS10795	COG0588	phosphoglycerate mutase activity
BTM29_RS10800	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BTM29_RS10805	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BTM29_RS10810	COG0544	peptidyl-prolyl cis-trans isomerase activity
BTM29_RS10830	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BTM29_RS10840	COG1466	dna polymerase III delta subunit
BTM29_RS10845	COG0658	competence protein
BTM29_RS10845	COG2333	competence protein COMEC
BTM29_RS10850	COG1555	photosystem II stabilization
BTM29_RS10850	COG1596	polysaccharide export
BTM29_RS10855	COG3480	Lon protease (S16) C-terminal proteolytic domain
BTM29_RS10860	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BTM29_RS10865	COG0742	ribosomal rna small subunit methyltransferase
BTM29_RS10870	COG4471	UPF0298 protein
BTM29_RS10875	COG0772	Belongs to the SEDS family
BTM29_RS10880	COG1217	gtp-binding protein TYPA
BTM29_RS10885	COG0483	inositol monophosphate 1-phosphatase activity
BTM29_RS10890	COG4476	Belongs to the UPF0223 family
BTM29_RS10915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BTM29_RS10920	COG0242	peptide deformylase activity
BTM29_RS10925	COG5503	Protein of unknown function (DUF1447)
BTM29_RS10930	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BTM29_RS10940	COG1597	lipid kinase activity
BTM29_RS10945	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BTM29_RS10955	COG0406	alpha-ribazole phosphatase activity
BTM29_RS10960	COG0482	sulfurtransferase activity
BTM29_RS10970	COG1104	cysteine desulfurase activity
BTM29_RS10985	COG0494	nUDIX hydrolase
BTM29_RS10995	COG1278	Cold shock
BTM29_RS11000	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BTM29_RS11005	COG3599	regulation of cell shape
BTM29_RS11030	COG0849	cell division
BTM29_RS11050	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BTM29_RS11055	COG0768	penicillin binding
BTM29_RS11065	COG0275	rRNA processing
BTM29_RS11070	COG2001	Belongs to the MraZ family
BTM29_RS11085	COG2894	cell division
BTM29_RS11090	COG0850	regulation of cytokinetic process
BTM29_RS11095	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BTM29_RS11100	COG1792	Involved in formation and maintenance of cell shape
BTM29_RS11105	COG1077	Cell shape determining protein MreB Mrl
BTM29_RS11120	COG0525	valine-tRNA ligase activity
BTM29_RS11125	COG0301	tRNA thio-modification
BTM29_RS11130	COG1104	cysteine desulfurase activity
BTM29_RS11135	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BTM29_RS11145	COG4493	Belongs to the UPF0637 family
BTM29_RS11150	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BTM29_RS11160	COG0589	response to stress
BTM29_RS11170	COG0509	glycine decarboxylation via glycine cleavage system
BTM29_RS11175	COG0772	Belongs to the SEDS family
BTM29_RS11190	COG1077	Cell shape determining protein MreB Mrl
BTM29_RS11195	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BTM29_RS11205	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BTM29_RS11210	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BTM29_RS11225	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BTM29_RS11230	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BTM29_RS11240	COG0356	it plays a direct role in the translocation of protons across the membrane
BTM29_RS11245	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BTM29_RS11250	COG0009	L-threonylcarbamoyladenylate synthase
BTM29_RS11255	COG2890	protein-(glutamine-N5) methyltransferase activity
BTM29_RS11265	COG1435	thymidine kinase activity
BTM29_RS11270	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BTM29_RS11280	COG1132	(ABC) transporter
BTM29_RS11290	COG1266	CAAX protease self-immunity
BTM29_RS11435	COG0270	DNA (cytosine-5-)-methyltransferase activity
BTM29_RS11555	COG4716	Myosin-crossreactive antigen
BTM29_RS11570	COG1704	LemA family
BTM29_RS11575	COG0501	Belongs to the peptidase M48B family
BTM29_RS11585	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BTM29_RS11600	COG0393	Putative heavy-metal-binding
BTM29_RS11625	COG2261	transglycosylase associated protein
BTM29_RS11650	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BTM29_RS11680	COG1215	transferase activity, transferring glycosyl groups
BTM29_RS11695	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
BTM29_RS11705	COG5646	InterPro IPR014922
BTM29_RS11720	COG4221	oxidoreductase activity
BTM29_RS11725	COG1733	regulation of RNA biosynthetic process
BTM29_RS11745	COG0657	acetylesterase activity
BTM29_RS11760	COG1063	alcohol dehydrogenase
BTM29_RS11770	COG1125	glycine betaine transport
BTM29_RS11770	COG0517	IMP dehydrogenase activity
BTM29_RS11775	COG1959	2 iron, 2 sulfur cluster binding
BTM29_RS11800	COG2249	NAD(P)H dehydrogenase (quinone) activity
BTM29_RS11805	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BTM29_RS11810	COG4120	Belongs to the binding-protein-dependent transport system permease family
BTM29_RS11820	COG1132	(ABC) transporter
BTM29_RS11835	COG2814	Major facilitator Superfamily
BTM29_RS11840	COG1733	regulation of RNA biosynthetic process
BTM29_RS11850	COG0656	L-ascorbic acid biosynthetic process
BTM29_RS11855	COG0789	Transcriptional regulator
BTM29_RS11860	COG0477	Major facilitator Superfamily
BTM29_RS11880	COG0475	glutathione-regulated potassium exporter activity
BTM29_RS11880	COG0569	domain protein
BTM29_RS11885	COG1956	GAF domain-containing protein
BTM29_RS11900	COG0789	Transcriptional regulator
BTM29_RS11965	COG1132	(ABC) transporter
BTM29_RS11990	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BTM29_RS11995	COG1737	Transcriptional regulator
BTM29_RS12035	COG0561	phosphatase activity
BTM29_RS12040	COG0561	phosphatase activity
BTM29_RS12045	COG0561	phosphatase activity
BTM29_RS12055	COG0110	maltose O-acetyltransferase activity
BTM29_RS12060	COG1902	pentaerythritol trinitrate reductase activity
BTM29_RS12070	COG2271	Major facilitator Superfamily
BTM29_RS12075	COG2096	Adenosyltransferase
BTM29_RS12085	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BTM29_RS12110	COG2252	PERMEase
BTM29_RS12140	COG1376	ErfK ybiS ycfS ynhG family protein
BTM29_RS12145	COG0166	Belongs to the GPI family
BTM29_RS12155	COG1368	sulfuric ester hydrolase activity
BTM29_RS12160	COG3850	Histidine kinase
BTM29_RS12160	COG5002	protein histidine kinase activity
BTM29_RS12165	COG0745	RESPONSE REGULATOR receiver
BTM29_RS12170	COG0561	phosphatase activity
BTM29_RS12175	COG0604	alcohol dehydrogenase
BTM29_RS12185	COG0431	NADPH-dependent FMN reductase
BTM29_RS12200	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BTM29_RS12210	COG0163	prenyltransferase activity
BTM29_RS12215	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BTM29_RS12220	COG0583	DNA-binding transcription factor activity
BTM29_RS12225	COG2409	Drug exporters of the RND superfamily
BTM29_RS12225	COG1033	growth of symbiont in host cell
BTM29_RS12230	COG1309	transcriptional regulator
BTM29_RS12240	COG1464	Belongs to the NlpA lipoprotein family
BTM29_RS12245	COG2011	ABC-type metal ion transport system permease component
BTM29_RS12250	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BTM29_RS12260	COG1464	Belongs to the NlpA lipoprotein family
BTM29_RS12270	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BTM29_RS12305	COG0446	pyridine nucleotide-disulphide oxidoreductase
BTM29_RS12315	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BTM29_RS12325	COG0531	amino acid
BTM29_RS12330	COG2814	Major facilitator Superfamily
BTM29_RS12335	COG0519	Catalyzes the synthesis of GMP from XMP
BTM29_RS12340	COG2076	Multidrug Resistance protein
BTM29_RS12360	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BTM29_RS12540	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BTM29_RS12560	COG2217	Heavy metal translocating P-type atpase
BTM29_RS12570	COG2801	Transposase and inactivated derivatives
BTM29_RS12645	COG0446	pyridine nucleotide-disulphide oxidoreductase
BTM29_RS12665	COG1192	Involved in chromosome partitioning
BTM29_RS12675	COG0025	NhaP-type Na H and K H
BTM29_RS12705	COG0515	serine threonine protein kinase