locus-tag	class	description
LVIS_RS11545	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LVIS_RS11550	COG0592	DNA-directed DNA polymerase activity
LVIS_RS11555	COG2501	S4 domain
LVIS_RS11560	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LVIS_RS11565	COG0187	DNA topoisomerase II activity
LVIS_RS11570	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LVIS_RS11575	COG0360	Binds together with S18 to 16S ribosomal RNA
LVIS_RS11580	COG0629	single-stranded DNA binding
LVIS_RS11585	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LVIS_RS11595	COG4166	transmembrane transport
LVIS_RS11610	COG4166	transmembrane transport
LVIS_RS11630	COG0359	binds to the 23S rRNA
LVIS_RS11640	COG0305	Participates in initiation and elongation during chromosome replication
LVIS_RS11650	COG0655	NAD(P)H dehydrogenase (quinone) activity
LVIS_RS11655	COG2814	Major facilitator Superfamily
LVIS_RS11665	COG4166	transmembrane transport
LVIS_RS11685	COG0745	RESPONSE REGULATOR receiver
LVIS_RS11700	COG4853	Protein conserved in bacteria
LVIS_RS11705	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LVIS_RS11710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LVIS_RS11715	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LVIS_RS11735	COG0737	Belongs to the 5'-nucleotidase family
LVIS_RS11770	COG2826	transposase and inactivated derivatives, IS30 family
LVIS_RS11790	COG1397	ADP-ribosylglycohydrolase
LVIS_RS11795	COG0110	maltose O-acetyltransferase activity
LVIS_RS11820	COG4166	transmembrane transport
LVIS_RS11865	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LVIS_RS11890	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LVIS_RS11925	COG0531	amino acid
LVIS_RS11930	COG0076	glutamate decarboxylase activity
LVIS_RS11935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LVIS_RS11975	COG0702	epimerase
LVIS_RS12005	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LVIS_RS12025	COG2746	aminoglycoside 3-N-acetyltransferase activity
LVIS_RS12030	COG0667	Aldo Keto reductase
LVIS_RS12040	COG2814	Major facilitator Superfamily
LVIS_RS12050	COG0778	Nitroreductase
LVIS_RS12060	COG0488	(ABC) transporter
LVIS_RS12065	COG0477	Major facilitator Superfamily
LVIS_RS12075	COG1028	Short-chain dehydrogenase reductase Sdr
LVIS_RS12080	COG1609	Transcriptional regulator
LVIS_RS12085	COG1253	flavin adenine dinucleotide binding
LVIS_RS12100	COG0531	amino acid
LVIS_RS12105	COG0656	L-ascorbic acid biosynthetic process
LVIS_RS12125	COG1454	alcohol dehydrogenase
LVIS_RS12125	COG1012	belongs to the aldehyde dehydrogenase family
LVIS_RS12130	COG0791	NLP P60 protein
LVIS_RS12130	COG1388	LysM domain
LVIS_RS12145	COG1388	LysM domain
LVIS_RS12145	COG0791	NLP P60 protein
LVIS_RS12165	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
LVIS_RS12170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LVIS_RS12175	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LVIS_RS12190	COG1131	(ABC) transporter
LVIS_RS12195	COG1418	mRNA catabolic process
LVIS_RS12200	COG0534	Mate efflux family protein
LVIS_RS12205	COG1904	glucuronate isomerase
LVIS_RS12210	COG2211	Major facilitator Superfamily
LVIS_RS12220	COG3250	beta-galactosidase activity
LVIS_RS12225	COG0246	Mannitol dehydrogenase
LVIS_RS12235	COG0588	phosphoglycerate mutase activity
LVIS_RS12240	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LVIS_RS12245	COG1070	Carbohydrate kinase
LVIS_RS12250	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LVIS_RS12260	COG1312	Catalyzes the dehydration of D-mannonate
LVIS_RS12265	COG1609	Transcriptional regulator
LVIS_RS12270	COG2211	Major facilitator Superfamily
LVIS_RS12280	COG1904	glucuronate isomerase
LVIS_RS12285	COG2826	transposase and inactivated derivatives, IS30 family
LVIS_RS12300	COG0477	Major facilitator Superfamily
LVIS_RS12320	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LVIS_RS12325	COG2188	Transcriptional regulator
LVIS_RS12335	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LVIS_RS12365	COG0564	pseudouridine synthase activity
LVIS_RS12395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LVIS_RS12400	COG0601	transmembrane transport
LVIS_RS12405	COG4608	Belongs to the ABC transporter superfamily
LVIS_RS12420	COG0095	Lipoate-protein ligase
LVIS_RS12435	COG2115	Belongs to the xylose isomerase family
LVIS_RS12455	COG5646	InterPro IPR014922
LVIS_RS12470	COG1881	PFAM PEBP family protein
LVIS_RS12495	COG0656	L-ascorbic acid biosynthetic process
LVIS_RS12510	COG1757	Na H antiporter
LVIS_RS12520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LVIS_RS12525	COG3290	protein histidine kinase activity
LVIS_RS12530	COG4565	transcriptional regulatory protein
LVIS_RS12540	COG1309	transcriptional regulator
LVIS_RS12575	COG3479	Phenolic acid decarboxylase
LVIS_RS12580	COG1695	Transcriptional regulator
LVIS_RS12595	COG2153	protein acetylation
LVIS_RS12600	COG1846	Transcriptional regulator
LVIS_RS12630	COG2826	transposase and inactivated derivatives, IS30 family
LVIS_RS12635	COG1914	H( )-stimulated, divalent metal cation uptake system
LVIS_RS12640	COG0516	GMP reductase activity
LVIS_RS12645	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LVIS_RS12650	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LVIS_RS12655	COG1309	transcriptional regulator
LVIS_RS12665	COG2365	Tyrosine phosphatase family
LVIS_RS12685	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LVIS_RS12715	COG1335	isochorismatase
LVIS_RS12735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LVIS_RS12740	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LVIS_RS12745	COG0716	FMN binding
LVIS_RS12755	COG1113	amino acid transport
LVIS_RS12780	COG1064	alcohol dehydrogenase
LVIS_RS12790	COG1125	glycine betaine transport
LVIS_RS12790	COG0517	IMP dehydrogenase activity
LVIS_RS12800	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LVIS_RS12815	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LVIS_RS12835	COG0110	maltose O-acetyltransferase activity
LVIS_RS12860	COG1686	Belongs to the peptidase S11 family
LVIS_RS12865	COG0656	L-ascorbic acid biosynthetic process
LVIS_RS12870	COG2217	Heavy metal translocating P-type atpase
LVIS_RS12880	COG0726	polysaccharide deacetylase
LVIS_RS12890	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LVIS_RS12895	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LVIS_RS12895	COG2755	lipolytic protein G-D-S-L family
LVIS_RS12940	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LVIS_RS12945	COG1942	4-Oxalocrotonate Tautomerase
LVIS_RS12960	COG1174	glycine betaine transport
LVIS_RS12965	COG1732	Glycine betaine
LVIS_RS12995	COG2837	iron assimilation
LVIS_RS13000	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LVIS_RS13015	COG0463	Glycosyl transferase, family 2
LVIS_RS13030	COG0628	permease
LVIS_RS13035	COG0577	efflux transmembrane transporter activity
LVIS_RS13040	COG1136	(ABC) transporter
LVIS_RS13045	COG0366	Alpha amylase catalytic
LVIS_RS13065	COG0028	Belongs to the TPP enzyme family
LVIS_RS13080	COG5002	protein histidine kinase activity
LVIS_RS13085	COG0745	RESPONSE REGULATOR receiver
LVIS_RS13095	COG0702	epimerase
LVIS_RS13100	COG1252	NADH dehydrogenase
LVIS_RS13105	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LVIS_RS13115	COG1012	belongs to the aldehyde dehydrogenase family
LVIS_RS13125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LVIS_RS13130	COG1028	Short-chain dehydrogenase reductase Sdr
LVIS_RS13135	COG1414	Transcriptional regulator
LVIS_RS13140	COG3775	system Galactitol-specific IIC component
LVIS_RS13155	COG1914	H( )-stimulated, divalent metal cation uptake system
LVIS_RS13165	COG1307	EDD domain protein, DegV family
LVIS_RS13170	COG0446	pyridine nucleotide-disulphide oxidoreductase
LVIS_RS13175	COG3118	belongs to the thioredoxin family
LVIS_RS13180	COG1937	Protein conserved in bacteria
LVIS_RS13185	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LVIS_RS13190	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LVIS_RS13200	COG0657	acetylesterase activity
LVIS_RS13205	COG1854	S-ribosylhomocysteine lyase activity
LVIS_RS13215	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LVIS_RS13225	COG0583	DNA-binding transcription factor activity
LVIS_RS13275	COG0745	RESPONSE REGULATOR receiver
LVIS_RS13280	COG5002	protein histidine kinase activity
LVIS_RS13285	COG1609	Transcriptional regulator
LVIS_RS13305	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LVIS_RS13320	COG0561	phosphatase activity
LVIS_RS13335	COG1393	Belongs to the ArsC family
LVIS_RS13340	COG3103	Sh3 type 3 domain protein
LVIS_RS13340	COG0791	NLP P60 protein
LVIS_RS13340	COG1388	LysM domain
LVIS_RS13360	COG1028	Short-chain dehydrogenase reductase Sdr
LVIS_RS13365	COG2211	Major facilitator Superfamily
LVIS_RS13375	COG2826	transposase and inactivated derivatives, IS30 family
LVIS_RS13380	COG2207	Transcriptional regulator
LVIS_RS13385	COG1028	Short-chain dehydrogenase reductase Sdr
LVIS_RS13395	COG1959	2 iron, 2 sulfur cluster binding
LVIS_RS13400	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LVIS_RS13415	COG1733	regulation of RNA biosynthetic process
LVIS_RS13420	COG2814	Major facilitator Superfamily
LVIS_RS13425	COG4989	oxidoreductase activity
LVIS_RS13430	COG1136	(ABC) transporter
LVIS_RS13480	COG2855	membrane
LVIS_RS13485	COG0583	DNA-binding transcription factor activity
LVIS_RS13490	COG2814	Major facilitator Superfamily
LVIS_RS13500	COG0488	(ABC) transporter
LVIS_RS13535	COG1725	Transcriptional regulator
LVIS_RS13540	COG1131	(ABC) transporter
LVIS_RS13550	COG3835	regulator
LVIS_RS13555	COG2610	gluconate transmembrane transporter activity
LVIS_RS13560	COG1929	Belongs to the glycerate kinase type-1 family
LVIS_RS13565	COG3428	Bacterial PH domain
LVIS_RS13610	COG1914	H( )-stimulated, divalent metal cation uptake system
LVIS_RS13620	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LVIS_RS13645	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LVIS_RS13650	COG2323	membrane
LVIS_RS13705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LVIS_RS13720	COG1609	Transcriptional regulator
LVIS_RS13735	COG3973	AAA domain
LVIS_RS13745	COG0248	Ppx GppA phosphatase
LVIS_RS13760	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LVIS_RS13770	COG1801	Protein of unknown function DUF72
LVIS_RS13775	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LVIS_RS13775	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LVIS_RS13780	COG0084	hydrolase, TatD family'
LVIS_RS13785	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
LVIS_RS13790	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LVIS_RS13795	COG4466	Protein conserved in bacteria
LVIS_RS13800	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LVIS_RS13805	COG1573	uracil-dna glycosylase
LVIS_RS13825	COG2723	6-phospho-beta-galactosidase activity
LVIS_RS13830	COG1940	carbohydrate kinase activity
LVIS_RS13855	COG1121	(ABC) transporter
LVIS_RS13860	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LVIS_RS13865	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LVIS_RS13870	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LVIS_RS13875	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LVIS_RS13890	COG2188	Transcriptional regulator
LVIS_RS13895	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
LVIS_RS13900	COG0561	phosphatase activity
LVIS_RS13905	COG1078	dGTPase activity
LVIS_RS13910	COG0095	Lipoate-protein ligase
LVIS_RS13920	COG3343	RNA polymerase activity
LVIS_RS13925	COG0504	CTP synthase activity
LVIS_RS13945	COG0028	Belongs to the TPP enzyme family
LVIS_RS13950	COG3527	Alpha-acetolactate decarboxylase
LVIS_RS13960	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LVIS_RS13965	COG0254	rRNA binding
LVIS_RS13970	COG3764	Sortase (surface protein transpeptidase)
LVIS_RS13980	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LVIS_RS13985	COG1704	LemA family
LVIS_RS13990	COG0501	Belongs to the peptidase M48B family
LVIS_RS14000	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LVIS_RS14015	COG0736	holo-[acyl-carrier-protein] synthase activity
LVIS_RS14020	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LVIS_RS14030	COG2337	Toxic component of a toxin-antitoxin (TA) module
LVIS_RS14050	COG0193	aminoacyl-tRNA hydrolase activity
LVIS_RS14055	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LVIS_RS14060	COG2244	polysaccharide biosynthetic process
LVIS_RS14065	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LVIS_RS14075	COG1098	S1 RNA binding domain
LVIS_RS14080	COG0037	tRNA processing
LVIS_RS14095	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LVIS_RS14100	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LVIS_RS14145	COG3104	oligopeptide transport
LVIS_RS14165	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LVIS_RS14170	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LVIS_RS14175	COG2188	Transcriptional regulator
LVIS_RS14190	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LVIS_RS14195	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LVIS_RS14205	COG2183	response to ionizing radiation
LVIS_RS14210	COG3091	SprT-like family
LVIS_RS14215	COG0083	homoserine kinase activity
LVIS_RS14245	COG0534	Mate efflux family protein
LVIS_RS14260	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
LVIS_RS14260	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LVIS_RS14265	COG3715	PTS system
LVIS_RS14270	COG3716	PTS system mannose fructose sorbose family IID component
LVIS_RS14275	COG0628	permease
LVIS_RS14305	COG1511	domain protein
LVIS_RS14310	COG0803	Belongs to the bacterial solute-binding protein 9 family
LVIS_RS14315	COG1316	TRANSCRIPTIONal
LVIS_RS14325	COG0697	spore germination
LVIS_RS14330	COG0588	phosphoglycerate mutase activity
LVIS_RS14345	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LVIS_RS14355	COG0756	dUTP diphosphatase activity
LVIS_RS14365	COG4956	integral membrane protein (PIN domain superfamily)
LVIS_RS14370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LVIS_RS14375	COG0215	cysteine-tRNA ligase activity
LVIS_RS14380	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
LVIS_RS14385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LVIS_RS14405	COG0250	Participates in transcription elongation, termination and antitermination
LVIS_RS14410	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LVIS_RS14415	COG0081	regulation of translation
LVIS_RS14420	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LVIS_RS14425	COG0222	ribosome binding
LVIS_RS14430	COG0392	lysyltransferase activity
LVIS_RS14430	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LVIS_RS14440	COG1250	3-hydroxyacyl-CoA dehydrogenase
LVIS_RS14445	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LVIS_RS14455	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LVIS_RS14460	COG2813	Specifically methylates the guanine in position
LVIS_RS14470	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LVIS_RS14475	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LVIS_RS14480	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LVIS_RS14490	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LVIS_RS14495	COG3870	Protein conserved in bacteria
LVIS_RS14500	COG0470	DNA polymerase III
LVIS_RS14505	COG4467	Involved in initiation control of chromosome replication
LVIS_RS14520	COG1214	PFAM Peptidase M22, glycoprotease
LVIS_RS14530	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LVIS_RS14535	COG2807	transmembrane transport
LVIS_RS14540	COG0640	Transcriptional regulator
LVIS_RS14545	COG0488	(ABC) transporter
LVIS_RS14550	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
LVIS_RS14555	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LVIS_RS14560	COG0459	protein refolding
LVIS_RS14565	COG0531	amino acid
LVIS_RS14570	COG1346	cytolysis
LVIS_RS14580	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LVIS_RS14585	COG1739	Uncharacterized protein family UPF0029
LVIS_RS14590	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
LVIS_RS14605	COG0653	protein targeting
LVIS_RS14610	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LVIS_RS14620	COG0745	RESPONSE REGULATOR receiver
LVIS_RS14625	COG5002	protein histidine kinase activity
LVIS_RS14635	COG0573	inorganic phosphate transmembrane transporter activity
LVIS_RS14640	COG0581	inorganic phosphate transmembrane transporter activity
LVIS_RS14645	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LVIS_RS14650	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LVIS_RS14655	COG0704	Plays a role in the regulation of phosphate uptake
LVIS_RS14660	COG1983	PspC domain protein
LVIS_RS14670	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LVIS_RS14675	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LVIS_RS14680	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LVIS_RS14685	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LVIS_RS14690	COG0492	ferredoxin-NADP+ reductase activity
LVIS_RS14705	COG0556	nucleotide-excision repair
LVIS_RS14710	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LVIS_RS14720	COG1660	Displays ATPase and GTPase activities
LVIS_RS14730	COG1481	regulation of sporulation
LVIS_RS14735	COG0740	serine-type endopeptidase activity
LVIS_RS14755	COG4684	Psort location CytoplasmicMembrane, score
LVIS_RS14775	COG0126	phosphoglycerate kinase activity
LVIS_RS14780	COG0149	triose-phosphate isomerase activity
LVIS_RS14785	COG0148	phosphopyruvate hydratase activity
LVIS_RS14795	COG0038	chloride channel
LVIS_RS14800	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LVIS_RS14810	COG0557	exoribonuclease II activity
LVIS_RS14815	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LVIS_RS14830	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LVIS_RS14835	COG0280	phosphate acetyltransferase
LVIS_RS14840	COG0802	atpase or kinase
LVIS_RS14850	COG0667	Aldo Keto reductase
LVIS_RS14860	COG0708	Exodeoxyribonuclease III
LVIS_RS14865	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LVIS_RS14870	COG0025	NhaP-type Na H and K H
LVIS_RS14880	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
LVIS_RS14890	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LVIS_RS14895	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LVIS_RS14900	COG0363	glucosamine-6-phosphate deaminase activity
LVIS_RS14905	COG1705	Flagellar rod assembly protein muramidase FlgJ
LVIS_RS14905	COG1388	LysM domain
LVIS_RS14925	COG1134	teichoic acid transport
LVIS_RS14955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LVIS_RS14960	COG1120	ATPase activity
LVIS_RS14965	COG0248	Ppx GppA phosphatase
LVIS_RS14970	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LVIS_RS14980	COG3475	LICD family
LVIS_RS15005	COG3759	membrane
LVIS_RS15040	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LVIS_RS15060	COG1970	mechanosensitive ion channel activity
LVIS_RS15070	COG2264	protein methyltransferase activity
LVIS_RS15075	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LVIS_RS15085	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LVIS_RS15090	COG1490	D-aminoacyl-tRNA deacylase activity
LVIS_RS15100	COG3001	Fructosamine kinase
LVIS_RS15105	COG0860	N-Acetylmuramoyl-L-alanine amidase
LVIS_RS15115	COG0124	histidyl-tRNA synthetase
LVIS_RS15120	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LVIS_RS15125	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LVIS_RS15130	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LVIS_RS15140	COG1682	transport, permease protein
LVIS_RS15145	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LVIS_RS15150	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LVIS_RS15155	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LVIS_RS15160	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LVIS_RS15170	COG1733	regulation of RNA biosynthetic process
LVIS_RS15175	COG1610	YqeY-like protein
LVIS_RS15180	COG1702	phosphate starvation-inducible protein PhoH
LVIS_RS15185	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LVIS_RS15190	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LVIS_RS15195	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LVIS_RS15200	COG1381	Involved in DNA repair and RecF pathway recombination
LVIS_RS15205	COG0752	glycyl-tRNA synthetase alpha subunit
LVIS_RS15210	COG0751	glycine-tRNA ligase activity
LVIS_RS15215	COG0358	DNA primase activity
LVIS_RS15225	COG1959	2 iron, 2 sulfur cluster binding
LVIS_RS15230	COG1033	growth of symbiont in host cell
LVIS_RS15230	COG2409	Drug exporters of the RND superfamily
LVIS_RS15235	COG2384	SAM-dependent methyltransferase
LVIS_RS15240	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LVIS_RS15250	COG0542	response to heat
LVIS_RS15255	COG0587	DNA-directed DNA polymerase activity
LVIS_RS15270	COG2996	Protein conserved in bacteria
LVIS_RS15285	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LVIS_RS15290	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LVIS_RS15295	COG1187	pseudouridine synthase activity
LVIS_RS15300	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
LVIS_RS15310	COG0514	ATP-dependent DNA helicase (RecQ)
LVIS_RS15315	COG1705	Flagellar rod assembly protein muramidase FlgJ
LVIS_RS15315	COG1388	LysM domain
LVIS_RS15320	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LVIS_RS15325	COG0539	negative regulation of cytoplasmic translation
LVIS_RS15330	COG1160	GTP binding
LVIS_RS15340	COG0457	Tetratricopeptide repeat
LVIS_RS15345	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LVIS_RS15350	COG0617	tRNA 3'-terminal CCA addition
LVIS_RS15355	COG0488	(ABC) transporter
LVIS_RS15360	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LVIS_RS15365	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LVIS_RS15370	COG1272	protein, Hemolysin III
LVIS_RS15375	COG1307	EDD domain protein, DegV family
LVIS_RS15380	COG2755	lipolytic protein G-D-S-L family
LVIS_RS15390	COG4479	Belongs to the UPF0346 family
LVIS_RS15410	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LVIS_RS15415	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LVIS_RS15420	COG0758	DNA mediated transformation
LVIS_RS15425	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LVIS_RS15435	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LVIS_RS15440	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LVIS_RS15450	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LVIS_RS15455	COG0187	DNA topoisomerase II activity
LVIS_RS15465	COG0583	DNA-binding transcription factor activity
LVIS_RS15470	COG1227	inorganic diphosphatase activity
LVIS_RS15480	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LVIS_RS15495	COG4974	Belongs to the 'phage' integrase family
LVIS_RS15505	COG2226	methyltransferase
LVIS_RS15525	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LVIS_RS15540	COG2246	polysaccharide biosynthetic process
LVIS_RS15545	COG4720	Psort location CytoplasmicMembrane, score
LVIS_RS15550	COG1307	EDD domain protein, DegV family
LVIS_RS15555	COG2270	Major facilitator Superfamily
LVIS_RS15565	COG1846	Transcriptional regulator
LVIS_RS15570	COG1293	RNA-binding protein homologous to eukaryotic snRNP
LVIS_RS15575	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LVIS_RS15585	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LVIS_RS15590	COG0564	pseudouridine synthase activity
LVIS_RS15595	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LVIS_RS15600	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LVIS_RS15615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LVIS_RS15650	COG0004	ammonium transporteR
LVIS_RS15660	COG0116	Belongs to the methyltransferase superfamily
LVIS_RS15665	COG3599	regulation of cell shape
LVIS_RS15670	COG4474	Belongs to the UPF0398 family
LVIS_RS15675	COG3331	DNA recombination
LVIS_RS15680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LVIS_RS15710	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LVIS_RS15710	COG1199	ATP-dependent helicase activity
LVIS_RS15730	COG1304	FMN binding
LVIS_RS15735	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
LVIS_RS15735	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LVIS_RS15745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LVIS_RS15785	COG0789	Transcriptional regulator
LVIS_RS15800	COG3158	transport of potassium into the cell
LVIS_RS15805	COG2807	transmembrane transport
LVIS_RS15810	COG0025	NhaP-type Na H and K H
LVIS_RS15825	COG1309	transcriptional regulator
LVIS_RS15860	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LVIS_RS15870	COG0577	efflux transmembrane transporter activity
LVIS_RS15870	COG1136	(ABC) transporter
LVIS_RS15880	COG1215	transferase activity, transferring glycosyl groups
LVIS_RS15895	COG3655	Transcriptional regulator
LVIS_RS15910	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LVIS_RS15915	COG1942	4-Oxalocrotonate Tautomerase
LVIS_RS15920	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LVIS_RS15945	COG0446	pyridine nucleotide-disulphide oxidoreductase
LVIS_RS15965	COG1162	GTPase activity
LVIS_RS15970	COG0667	Aldo Keto reductase
LVIS_RS15975	COG0789	Transcriptional regulator
LVIS_RS15980	COG0583	DNA-binding transcription factor activity
LVIS_RS15990	COG0693	protein deglycase activity
LVIS_RS16030	COG1694	Mazg nucleotide pyrophosphohydrolase
LVIS_RS16035	COG1268	BioY protein
LVIS_RS16045	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LVIS_RS16050	COG0825	malonyl-CoA metabolic process
LVIS_RS16055	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LVIS_RS16060	COG0439	Biotin carboxylase
LVIS_RS16065	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LVIS_RS16070	COG0511	ligase activity, forming carbon-carbon bonds
LVIS_RS16080	COG1028	Short-chain dehydrogenase reductase Sdr
LVIS_RS16090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LVIS_RS16095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LVIS_RS16105	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LVIS_RS16115	COG0335	large ribosomal subunit rRNA binding
LVIS_RS16120	COG0336	Belongs to the RNA methyltransferase TrmD family
LVIS_RS16125	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LVIS_RS16130	COG1837	Belongs to the UPF0109 family
LVIS_RS16135	COG0228	four-way junction DNA binding
LVIS_RS16165	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
LVIS_RS16170	COG0552	protein localization to endoplasmic reticulum
LVIS_RS16175	COG1196	nuclear chromosome segregation
LVIS_RS16180	COG0571	ribonuclease III activity
LVIS_RS16185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LVIS_RS16190	COG0416	fatty acid biosynthetic process
LVIS_RS16195	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LVIS_RS16200	COG1461	Dihydroxyacetone kinase
LVIS_RS16205	COG1302	Protein conserved in bacteria
LVIS_RS16210	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LVIS_RS16215	COG1564	THIamine pyrophosphokinase
LVIS_RS16220	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LVIS_RS16225	COG1162	GTPase activity
LVIS_RS16230	COG0515	serine threonine protein kinase
LVIS_RS16230	COG2815	serine threonine protein kinase
LVIS_RS16235	COG0631	protein serine/threonine phosphatase activity
LVIS_RS16240	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LVIS_RS16240	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LVIS_RS16245	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LVIS_RS16250	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LVIS_RS16255	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LVIS_RS16260	COG1758	RNA polymerase activity
LVIS_RS16280	COG0497	DNA recombination
LVIS_RS16285	COG1438	arginine binding
LVIS_RS16290	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
LVIS_RS16300	COG1722	exodeoxyribonuclease VII activity
LVIS_RS16305	COG1570	exodeoxyribonuclease VII activity
LVIS_RS16310	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LVIS_RS16315	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LVIS_RS16320	COG1302	Protein conserved in bacteria
LVIS_RS16325	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LVIS_RS16330	COG0006	proline dipeptidase activity
LVIS_RS16335	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LVIS_RS16340	COG2868	ribosomal protein
LVIS_RS16345	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LVIS_RS16375	COG0789	Transcriptional regulator
LVIS_RS16380	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LVIS_RS16385	COG0584	glycerophosphoryl diester phosphodiesterase
LVIS_RS16400	COG1940	carbohydrate kinase activity
LVIS_RS16410	COG0457	Tetratricopeptide repeat
LVIS_RS16410	COG0705	Rhomboid family
LVIS_RS16415	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LVIS_RS16420	COG0768	penicillin binding
LVIS_RS16425	COG2155	Conserved Protein
LVIS_RS16445	COG0572	uridine kinase
LVIS_RS16450	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LVIS_RS16455	COG0072	phenylalanine-tRNA ligase activity
LVIS_RS16455	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LVIS_RS16460	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LVIS_RS16465	COG1733	regulation of RNA biosynthetic process
LVIS_RS16475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LVIS_RS16480	COG1254	Belongs to the acylphosphatase family
LVIS_RS16485	COG0706	membrane insertase activity
LVIS_RS16495	COG5002	protein histidine kinase activity
LVIS_RS16500	COG0745	RESPONSE REGULATOR receiver
LVIS_RS16505	COG1064	alcohol dehydrogenase
LVIS_RS16510	COG5549	protein import
LVIS_RS16510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LVIS_RS16515	COG0640	Transcriptional regulator
LVIS_RS16520	COG0561	phosphatase activity
LVIS_RS16525	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LVIS_RS16535	COG1323	Belongs to the UPF0348 family
LVIS_RS16540	COG2226	methyltransferase
LVIS_RS16545	COG0799	negative regulation of ribosome biogenesis
LVIS_RS16550	COG1713	HD superfamily hydrolase involved in NAD metabolism
LVIS_RS16555	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LVIS_RS16565	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LVIS_RS16570	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
LVIS_RS16575	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LVIS_RS16580	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LVIS_RS16585	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LVIS_RS16590	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LVIS_RS16595	COG1484	DNA-dependent DNA replication
LVIS_RS16605	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LVIS_RS16610	COG0237	dephospho-CoA kinase activity
LVIS_RS16615	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LVIS_RS16620	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LVIS_RS16620	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LVIS_RS16625	COG0402	S-adenosylhomocysteine deaminase activity
LVIS_RS16645	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LVIS_RS16650	COG1674	ftsk spoiiie
LVIS_RS16655	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LVIS_RS16660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LVIS_RS16670	COG1113	amino acid transport
LVIS_RS16680	COG0589	response to stress
LVIS_RS16690	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LVIS_RS16695	COG1187	pseudouridine synthase activity
LVIS_RS16700	COG2244	polysaccharide biosynthetic process
LVIS_RS16715	COG1129	ABC transporter
LVIS_RS16720	COG0495	leucyl-tRNA aminoacylation
LVIS_RS16725	COG0671	phosphoesterase, PA-phosphatase related
LVIS_RS16730	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
LVIS_RS16740	COG1215	transferase activity, transferring glycosyl groups
LVIS_RS16925	COG3728	DNA packaging
LVIS_RS16925	COG5484	DNA packaging
LVIS_RS17030	COG0305	Participates in initiation and elongation during chromosome replication
LVIS_RS17125	COG4862	establishment of competence for transformation
LVIS_RS17130	COG1393	Belongs to the ArsC family
LVIS_RS17135	COG1234	tRNA 3'-trailer cleavage
LVIS_RS17255	COG0539	negative regulation of cytoplasmic translation
LVIS_RS17260	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LVIS_RS17265	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LVIS_RS17270	COG0586	Pfam SNARE associated Golgi protein
LVIS_RS17275	COG0656	L-ascorbic acid biosynthetic process
LVIS_RS17280	COG1028	Short-chain dehydrogenase reductase Sdr
LVIS_RS17285	COG0531	amino acid
LVIS_RS17310	COG0647	UMP catabolic process
LVIS_RS17315	COG4470	Protein conserved in bacteria
LVIS_RS17320	COG0737	Belongs to the 5'-nucleotidase family
LVIS_RS17330	COG0656	L-ascorbic acid biosynthetic process
LVIS_RS17335	COG1113	amino acid transport
LVIS_RS17345	COG0827	DNA restriction-modification system
LVIS_RS17365	COG4537	Required for transformation and DNA binding
LVIS_RS17370	COG1459	type II secretion system
LVIS_RS17375	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LVIS_RS17380	COG0217	transcriptional regulatory protein
LVIS_RS17385	COG0765	amino acid transport
LVIS_RS17390	COG1126	abc transporter atp-binding protein
LVIS_RS17400	COG1609	Transcriptional regulator
LVIS_RS17405	COG0006	proline dipeptidase activity
LVIS_RS17420	COG0668	transmembrane transport
LVIS_RS17430	COG0640	Transcriptional regulator
LVIS_RS17435	COG0517	IMP dehydrogenase activity
LVIS_RS17445	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LVIS_RS17450	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LVIS_RS17455	COG1719	4-vinyl reductase, 4VR
LVIS_RS17460	COG3118	belongs to the thioredoxin family
LVIS_RS17465	COG1193	negative regulation of DNA recombination
LVIS_RS17480	COG3906	Belongs to the UPF0473 family
LVIS_RS17485	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LVIS_RS17490	COG4472	Bacterial protein of unknown function (DUF965)
LVIS_RS17495	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LVIS_RS17500	COG0513	Belongs to the DEAD box helicase family
LVIS_RS17505	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LVIS_RS17510	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LVIS_RS17515	COG1862	Preprotein translocase
LVIS_RS17520	COG0343	queuine tRNA-ribosyltransferase activity
LVIS_RS17525	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LVIS_RS17530	COG2255	four-way junction helicase activity
LVIS_RS17535	COG0632	four-way junction helicase activity
LVIS_RS17540	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LVIS_RS17545	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LVIS_RS17550	COG1692	metallophosphoesterase
LVIS_RS17555	COG1418	mRNA catabolic process
LVIS_RS17560	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LVIS_RS17565	COG1546	Belongs to the CinA family
LVIS_RS17565	COG1058	Belongs to the CinA family
LVIS_RS17570	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LVIS_RS17575	COG1426	Protein conserved in bacteria
LVIS_RS17580	COG0612	Peptidase, M16
LVIS_RS17585	COG0612	Peptidase, M16
LVIS_RS17590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LVIS_RS17600	COG0765	amino acid transport
LVIS_RS17605	COG2894	cell division
LVIS_RS17610	COG0850	regulation of cytokinetic process
LVIS_RS17620	COG1792	Involved in formation and maintenance of cell shape
LVIS_RS17625	COG1077	Cell shape determining protein MreB Mrl
LVIS_RS17630	COG2003	Belongs to the UPF0758 family
LVIS_RS17635	COG0285	dihydrofolate synthase activity
LVIS_RS17640	COG0525	valine-tRNA ligase activity
LVIS_RS17650	COG0301	tRNA thio-modification
LVIS_RS17655	COG1104	cysteine desulfurase activity
LVIS_RS17660	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
LVIS_RS17665	COG1956	GAF domain-containing protein
LVIS_RS17670	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LVIS_RS17680	COG4493	Belongs to the UPF0637 family
LVIS_RS17690	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LVIS_RS17700	COG0589	response to stress
LVIS_RS17715	COG1181	Belongs to the D-alanine--D-alanine ligase family
LVIS_RS17730	COG0509	glycine decarboxylation via glycine cleavage system
LVIS_RS17735	COG0772	Belongs to the SEDS family
LVIS_RS17745	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LVIS_RS17750	COG1077	Cell shape determining protein MreB Mrl
LVIS_RS17755	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LVIS_RS17765	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LVIS_RS17770	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LVIS_RS17775	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LVIS_RS17780	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LVIS_RS17785	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LVIS_RS17790	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LVIS_RS17795	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LVIS_RS17800	COG0356	it plays a direct role in the translocation of protons across the membrane
LVIS_RS17805	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LVIS_RS17810	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LVIS_RS17815	COG0009	L-threonylcarbamoyladenylate synthase
LVIS_RS17820	COG2890	protein-(glutamine-N5) methyltransferase activity
LVIS_RS17825	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LVIS_RS17830	COG1435	thymidine kinase activity
LVIS_RS17835	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LVIS_RS17840	COG3442	glutamine amidotransferase
LVIS_RS17885	COG3706	GGDEF domain
LVIS_RS17885	COG2203	Gaf domain
LVIS_RS17885	COG5001	Diguanylate cyclase
LVIS_RS17885	COG4251	negative regulation of phosphorylation
LVIS_RS17890	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LVIS_RS17910	COG3293	Transposase
LVIS_RS17925	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
LVIS_RS17935	COG0166	Belongs to the GPI family
LVIS_RS17940	COG4975	Glucose uptake
LVIS_RS17945	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LVIS_RS17950	COG5002	protein histidine kinase activity
LVIS_RS17950	COG3850	Histidine kinase
LVIS_RS17955	COG0745	RESPONSE REGULATOR receiver
LVIS_RS17970	COG0481	GTPase activity
LVIS_RS17975	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
LVIS_RS17980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LVIS_RS17985	COG1696	Membrane protein involved in D-alanine export
LVIS_RS17990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LVIS_RS18000	COG0484	heat shock protein binding
LVIS_RS18005	COG0443	Heat shock 70 kDa protein
LVIS_RS18010	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LVIS_RS18015	COG1420	regulation of RNA biosynthetic process
LVIS_RS18020	COG0196	riboflavin kinase activity
LVIS_RS18025	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LVIS_RS18030	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LVIS_RS18035	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LVIS_RS18045	COG2740	Nucleic-acid-binding protein implicated in transcription termination
LVIS_RS18050	COG0195	Participates in both transcription termination and antitermination
LVIS_RS18055	COG0779	Required for maturation of 30S ribosomal subunits
LVIS_RS18065	COG2176	DNA-directed DNA polymerase activity
LVIS_RS18070	COG0442	prolyl-tRNA aminoacylation
LVIS_RS18075	COG0750	zinc metalloprotease
LVIS_RS18080	COG4589	Belongs to the CDS family
LVIS_RS18085	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LVIS_RS18100	COG0528	UMP kinase activity
LVIS_RS18105	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LVIS_RS18110	COG0052	Belongs to the universal ribosomal protein uS2 family
LVIS_RS18120	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LVIS_RS18125	COG2827	Endonuclease containing a URI domain
LVIS_RS18130	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LVIS_RS18135	COG0204	Acyl-transferase
LVIS_RS18140	COG1132	(ABC) transporter
LVIS_RS18150	COG3763	UPF0154 protein
LVIS_RS18155	COG4224	UPF0291 protein
LVIS_RS18175	COG3425	synthase
LVIS_RS18180	COG2326	polyphosphate kinase activity
LVIS_RS18195	COG0105	UTP biosynthetic process
LVIS_RS18220	COG1597	lipid kinase activity
LVIS_RS18235	COG0589	response to stress
LVIS_RS18240	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LVIS_RS18245	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LVIS_RS18245	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LVIS_RS18250	COG5416	Lipopolysaccharide assembly protein A domain
LVIS_RS18255	COG1234	tRNA 3'-trailer cleavage
LVIS_RS18270	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LVIS_RS18275	COG0322	excinuclease ABC activity
LVIS_RS18290	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LVIS_RS18295	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LVIS_RS18300	COG0544	peptidyl-prolyl cis-trans isomerase activity
LVIS_RS18305	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LVIS_RS18320	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LVIS_RS18325	COG0268	Binds directly to 16S ribosomal RNA
LVIS_RS18330	COG1466	dna polymerase III delta subunit
LVIS_RS18335	COG0658	competence protein
LVIS_RS18335	COG2333	competence protein COMEC
LVIS_RS18340	COG2131	deaminase
LVIS_RS18345	COG1596	polysaccharide export
LVIS_RS18345	COG1555	photosystem II stabilization
LVIS_RS18350	COG3480	Lon protease (S16) C-terminal proteolytic domain
LVIS_RS18355	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LVIS_RS18360	COG0742	ribosomal rna small subunit methyltransferase
LVIS_RS18365	COG4471	UPF0298 protein
LVIS_RS18370	COG0772	Belongs to the SEDS family
LVIS_RS18375	COG1217	gtp-binding protein TYPA
LVIS_RS18380	COG0483	inositol monophosphate 1-phosphatase activity
LVIS_RS18385	COG4476	Belongs to the UPF0223 family
LVIS_RS18410	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LVIS_RS18415	COG0242	peptide deformylase activity
LVIS_RS18425	COG5503	Protein of unknown function (DUF1447)
LVIS_RS18430	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LVIS_RS18435	COG1597	lipid kinase activity
LVIS_RS18445	COG0791	NLP P60 protein
LVIS_RS18445	COG1388	LysM domain
LVIS_RS18455	COG0791	NLP P60 protein
LVIS_RS18470	COG1609	Transcriptional regulator
LVIS_RS18475	COG0667	Aldo Keto reductase
LVIS_RS18480	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LVIS_RS18485	COG4166	transmembrane transport
LVIS_RS18495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LVIS_RS18500	COG0765	amino acid transport
LVIS_RS18510	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LVIS_RS18515	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LVIS_RS18530	COG0482	sulfurtransferase activity
LVIS_RS18540	COG1104	cysteine desulfurase activity
LVIS_RS18545	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LVIS_RS18555	COG0494	nUDIX hydrolase
LVIS_RS18560	COG1278	Cold shock
LVIS_RS18565	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LVIS_RS18570	COG3599	regulation of cell shape
LVIS_RS18585	COG1799	cell septum assembly
LVIS_RS18590	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LVIS_RS18600	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LVIS_RS18605	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LVIS_RS18610	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LVIS_RS18615	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LVIS_RS18620	COG0768	penicillin binding
LVIS_RS18630	COG0275	rRNA processing
LVIS_RS18635	COG2001	Belongs to the MraZ family
LVIS_RS18650	COG1674	ftsk spoiiie
LVIS_RS18655	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LVIS_RS18665	COG0628	permease
LVIS_RS18670	COG3142	Participates in the control of copper homeostasis
LVIS_RS18710	COG0564	pseudouridine synthase activity
LVIS_RS18715	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LVIS_RS18720	COG2357	RelA SpoT domain protein
LVIS_RS18730	COG1307	EDD domain protein, DegV family
LVIS_RS18745	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LVIS_RS18750	COG0510	thiamine kinase activity
LVIS_RS18760	COG1131	(ABC) transporter
LVIS_RS18765	COG0537	adenosine 5'-monophosphoramidase activity
LVIS_RS18775	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LVIS_RS18785	COG4717	serine-type aminopeptidase activity
LVIS_RS18790	COG0420	3'-5' exonuclease activity
LVIS_RS18795	COG3679	Belongs to the UPF0342 family
LVIS_RS18800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LVIS_RS18805	COG1438	arginine binding
LVIS_RS18810	COG0018	arginyl-trna synthetase
LVIS_RS18825	COG3293	Transposase
LVIS_RS18835	COG5632	N-Acetylmuramoyl-L-alanine amidase
LVIS_RS18835	COG3266	domain, Protein
LVIS_RS18835	COG4193	domain, Protein
LVIS_RS18850	COG1794	racemase activity, acting on amino acids and derivatives
LVIS_RS18860	COG0367	asparagine synthase
LVIS_RS18895	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LVIS_RS18900	COG2801	Transposase and inactivated derivatives
LVIS_RS18920	COG1846	Transcriptional regulator
LVIS_RS18935	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LVIS_RS18940	COG1554	hydrolase, family 65, central catalytic
LVIS_RS18945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LVIS_RS18955	COG1428	Deoxynucleoside kinase
LVIS_RS18965	COG0477	Major facilitator Superfamily
LVIS_RS18970	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LVIS_RS18990	COG0393	Putative heavy-metal-binding
LVIS_RS19085	COG1368	sulfuric ester hydrolase activity
LVIS_RS19100	COG0438	transferase activity, transferring glycosyl groups
LVIS_RS19105	COG0438	transferase activity, transferring glycosyl groups
LVIS_RS19110	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LVIS_RS19125	COG0542	response to heat
LVIS_RS19145	COG0446	pyridine nucleotide-disulphide oxidoreductase
LVIS_RS19155	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LVIS_RS19165	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LVIS_RS19175	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LVIS_RS19180	COG0628	permease
LVIS_RS19185	COG3557	Belongs to the UPF0374 family
LVIS_RS19200	COG2137	regulation of response to DNA damage stimulus
LVIS_RS19210	COG1295	ribonuclease BN
LVIS_RS19220	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LVIS_RS19225	COG0463	Glycosyl transferase, family 2
LVIS_RS19230	COG2610	gluconate transmembrane transporter activity
LVIS_RS19250	COG0513	Belongs to the DEAD box helicase family
LVIS_RS19270	COG1737	Transcriptional regulator
LVIS_RS19275	COG1070	Carbohydrate kinase
LVIS_RS19285	COG0531	amino acid
LVIS_RS19290	COG0738	Major facilitator superfamily
LVIS_RS19295	COG1869	D-ribose catabolic process
LVIS_RS19300	COG2918	glutathione biosynthetic process
LVIS_RS19300	COG1181	Belongs to the D-alanine--D-alanine ligase family
LVIS_RS19310	COG2390	Transcriptional regulator
LVIS_RS19315	COG0813	purine-nucleoside phosphorylase activity
LVIS_RS19320	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LVIS_RS19325	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LVIS_RS19340	COG2365	Tyrosine phosphatase family
LVIS_RS19345	COG1902	pentaerythritol trinitrate reductase activity
LVIS_RS19365	COG1012	belongs to the aldehyde dehydrogenase family
LVIS_RS19380	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
LVIS_RS19390	COG4869	propanediol catabolic process
LVIS_RS19445	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LVIS_RS19465	COG2826	transposase and inactivated derivatives, IS30 family
LVIS_RS19475	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LVIS_RS19480	COG1597	lipid kinase activity
LVIS_RS19485	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LVIS_RS19490	COG0154	amidase activity
LVIS_RS19495	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LVIS_RS19500	COG4851	CamS sex pheromone cAM373 precursor
LVIS_RS19505	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LVIS_RS19515	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LVIS_RS19520	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LVIS_RS19535	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LVIS_RS19545	COG1294	oxidase, subunit
LVIS_RS19550	COG1271	oxidase subunit
LVIS_RS19560	COG2365	Tyrosine phosphatase family
LVIS_RS19565	COG2826	transposase and inactivated derivatives, IS30 family
LVIS_RS19570	COG1316	TRANSCRIPTIONal
LVIS_RS19575	COG0095	Lipoate-protein ligase
LVIS_RS19580	COG0531	amino acid
LVIS_RS19585	COG2502	aspartate--ammonia ligase
LVIS_RS19590	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LVIS_RS19600	COG0307	riboflavin synthase, alpha
LVIS_RS19605	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LVIS_RS19605	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LVIS_RS19610	COG0569	domain protein
LVIS_RS19615	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LVIS_RS19620	COG1482	cell wall glycoprotein biosynthetic process
LVIS_RS19625	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LVIS_RS19630	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LVIS_RS19635	COG0101	tRNA pseudouridine synthase activity
LVIS_RS19640	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LVIS_RS19645	COG1122	ATPase activity
LVIS_RS19650	COG1122	ATPase activity
LVIS_RS19655	COG0203	ribosomal protein L17
LVIS_RS19660	COG0202	RNA polymerase activity
LVIS_RS19665	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LVIS_RS19670	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LVIS_RS19675	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LVIS_RS19680	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LVIS_RS19695	COG0200	Binds to the 23S rRNA
LVIS_RS19700	COG1841	ribosomal large subunit assembly
LVIS_RS19705	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LVIS_RS19710	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LVIS_RS19715	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LVIS_RS19720	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LVIS_RS19725	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LVIS_RS19730	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LVIS_RS19735	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LVIS_RS19740	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LVIS_RS19745	COG0255	Belongs to the universal ribosomal protein uL29 family
LVIS_RS19750	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LVIS_RS19755	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LVIS_RS19760	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LVIS_RS19765	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LVIS_RS19770	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LVIS_RS19775	COG0089	rRNA binding
LVIS_RS19780	COG0088	Forms part of the polypeptide exit tunnel
LVIS_RS19785	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LVIS_RS19790	COG0051	transcription antitermination factor activity, RNA binding
LVIS_RS19800	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LVIS_RS19805	COG0049	tRNA binding
LVIS_RS19810	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LVIS_RS19820	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LVIS_RS19825	COG0085	RNA polymerase activity
LVIS_RS19835	COG0542	response to heat
LVIS_RS19840	COG4463	regulation of RNA biosynthetic process
LVIS_RS19885	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LVIS_RS19890	COG1428	Deoxynucleoside kinase
LVIS_RS19895	COG0833	amino acid
LVIS_RS19940	COG2826	transposase and inactivated derivatives, IS30 family
LVIS_RS19955	COG2814	Major facilitator Superfamily
LVIS_RS19965	COG2826	transposase and inactivated derivatives, IS30 family
LVIS_RS19970	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
LVIS_RS19995	COG0456	acetyltransferase
LVIS_RS20015	COG0564	pseudouridine synthase activity
LVIS_RS20030	COG0110	maltose O-acetyltransferase activity
LVIS_RS20035	COG2160	L-arabinose isomerase activity
LVIS_RS20060	COG0110	maltose O-acetyltransferase activity
LVIS_RS20075	COG3940	Belongs to the glycosyl hydrolase 43 family
LVIS_RS20090	COG0514	ATP-dependent DNA helicase (RecQ)
LVIS_RS20105	COG4690	dipeptidase activity
LVIS_RS20115	COG0308	aminopeptidase N
LVIS_RS20130	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LVIS_RS20130	COG0519	Catalyzes the synthesis of GMP from XMP
LVIS_RS20140	COG1072	(Pantothenic acid kinase))
LVIS_RS20145	COG3973	AAA domain
LVIS_RS20160	COG4608	Belongs to the ABC transporter superfamily
LVIS_RS20165	COG0444	Belongs to the ABC transporter superfamily
LVIS_RS20170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LVIS_RS20175	COG0601	transmembrane transport
LVIS_RS20180	COG4166	transmembrane transport
LVIS_RS20185	COG4166	transmembrane transport
LVIS_RS20190	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LVIS_RS20195	COG0765	amino acid transport
LVIS_RS20200	COG0765	amino acid transport
LVIS_RS20205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LVIS_RS20210	COG1126	abc transporter atp-binding protein
LVIS_RS20225	COG0735	belongs to the Fur family
LVIS_RS20240	COG0531	amino acid
LVIS_RS20245	COG2936	dipeptidyl-peptidase activity
LVIS_RS20250	COG2267	carboxylic ester hydrolase activity
LVIS_RS20255	COG1376	ErfK ybiS ycfS ynhG family protein
LVIS_RS20260	COG0488	(ABC) transporter
LVIS_RS20275	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LVIS_RS20280	COG4120	Belongs to the binding-protein-dependent transport system permease family
LVIS_RS20290	COG1307	EDD domain protein, DegV family
LVIS_RS20300	COG4120	Belongs to the binding-protein-dependent transport system permease family
LVIS_RS20315	COG2084	Dehydrogenase
LVIS_RS20320	COG0861	Integral membrane protein TerC family
LVIS_RS20330	COG1705	Flagellar rod assembly protein muramidase FlgJ
LVIS_RS20345	COG1028	Short-chain dehydrogenase reductase Sdr
LVIS_RS20360	COG2826	transposase and inactivated derivatives, IS30 family
LVIS_RS20365	COG2814	Major facilitator Superfamily
LVIS_RS20375	COG0789	Transcriptional regulator
LVIS_RS20380	COG0791	NLP P60 protein
LVIS_RS20380	COG1388	LysM domain
LVIS_RS20380	COG3103	Sh3 type 3 domain protein
LVIS_RS20390	COG0588	phosphoglycerate mutase activity
LVIS_RS20395	COG1368	sulfuric ester hydrolase activity
LVIS_RS20400	COG0492	ferredoxin-NADP+ reductase activity
LVIS_RS20430	COG0561	phosphatase activity
LVIS_RS20440	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LVIS_RS20460	COG1686	Belongs to the peptidase S11 family
LVIS_RS20465	COG1686	Belongs to the peptidase S11 family
LVIS_RS20475	COG4172	Belongs to the ABC transporter superfamily
LVIS_RS20485	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LVIS_RS20520	COG2233	PERMEase
LVIS_RS20525	COG4152	abc transporter atp-binding protein
LVIS_RS20530	COG1668	transmembrane transport
LVIS_RS20550	COG0656	L-ascorbic acid biosynthetic process
LVIS_RS20565	COG0076	glutamate decarboxylase activity
LVIS_RS20570	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LVIS_RS20575	COG3875	lactate racemase activity
LVIS_RS20580	COG1691	(AIR) carboxylase
LVIS_RS20585	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
LVIS_RS20590	COG1606	tRNA processing
LVIS_RS20595	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LVIS_RS20600	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
LVIS_RS20620	COG3842	ATPase activity
LVIS_RS20625	COG1176	ABC-type spermidine putrescine transport system, permease component I
LVIS_RS20640	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LVIS_RS20645	COG0581	inorganic phosphate transmembrane transporter activity
LVIS_RS20650	COG0573	inorganic phosphate transmembrane transporter activity
LVIS_RS20690	COG1132	(ABC) transporter
LVIS_RS20695	COG2826	transposase and inactivated derivatives, IS30 family
LVIS_RS20710	COG2706	6-phosphogluconolactonase activity
LVIS_RS20720	COG0531	amino acid
LVIS_RS20735	COG0735	belongs to the Fur family
LVIS_RS20760	COG0589	response to stress
LVIS_RS20770	COG1846	Transcriptional regulator
LVIS_RS20775	COG3590	peptidase
LVIS_RS20795	COG3590	peptidase
LVIS_RS20800	COG2096	Adenosyltransferase
LVIS_RS20805	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LVIS_RS20820	COG1609	Transcriptional regulator
LVIS_RS20825	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
LVIS_RS20830	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LVIS_RS20835	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LVIS_RS20840	COG2211	Major facilitator Superfamily
LVIS_RS20840	COG2190	(PTS) system
LVIS_RS20850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LVIS_RS20855	COG2017	converts alpha-aldose to the beta-anomer
LVIS_RS20860	COG1960	acyl-CoA dehydrogenase activity
LVIS_RS20870	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LVIS_RS20875	COG0604	alcohol dehydrogenase
LVIS_RS20880	COG0640	Transcriptional regulator
LVIS_RS20900	COG2814	Major facilitator Superfamily
LVIS_RS20905	COG0024	Methionine aminopeptidase
LVIS_RS20910	COG2226	methyltransferase
LVIS_RS20925	COG2094	Belongs to the DNA glycosylase MPG family
LVIS_RS20930	COG3189	MarR family transcriptional regulator
LVIS_RS20935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LVIS_RS20950	COG0110	maltose O-acetyltransferase activity
LVIS_RS20960	COG0328	RNA-DNA hybrid ribonuclease activity
LVIS_RS20970	COG0402	S-adenosylhomocysteine deaminase activity
LVIS_RS20980	COG0351	phosphomethylpyrimidine kinase
LVIS_RS20990	COG2249	NAD(P)H dehydrogenase (quinone) activity
LVIS_RS21005	COG2826	transposase and inactivated derivatives, IS30 family
LVIS_RS21015	COG1278	Cold shock
LVIS_RS21020	COG0400	carboxylic ester hydrolase activity
LVIS_RS21035	COG4166	transmembrane transport
LVIS_RS21055	COG0509	glycine decarboxylation via glycine cleavage system
LVIS_RS21060	COG0667	Aldo Keto reductase
LVIS_RS21070	COG0697	spore germination
LVIS_RS21075	COG2011	ABC-type metal ion transport system permease component
LVIS_RS21080	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LVIS_RS21085	COG1464	Belongs to the NlpA lipoprotein family
LVIS_RS21090	COG0519	Catalyzes the synthesis of GMP from XMP
LVIS_RS21095	COG4166	transmembrane transport
LVIS_RS21100	COG1472	Belongs to the glycosyl hydrolase 3 family
LVIS_RS21105	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
LVIS_RS21110	COG0419	ATPase involved in DNA repair
LVIS_RS21115	COG0420	3'-5' exonuclease activity
LVIS_RS21120	COG2818	Glycosylase
LVIS_RS21140	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LVIS_RS21150	COG0789	Transcriptional regulator
LVIS_RS21155	COG1309	transcriptional regulator
LVIS_RS21175	COG2814	Major facilitator Superfamily
LVIS_RS21180	COG2814	Major facilitator Superfamily
LVIS_RS21185	COG1902	pentaerythritol trinitrate reductase activity
LVIS_RS21190	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
LVIS_RS21235	COG0163	prenyltransferase activity
LVIS_RS21240	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LVIS_RS21245	COG0583	DNA-binding transcription factor activity
LVIS_RS21250	COG0242	peptide deformylase activity
LVIS_RS21265	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LVIS_RS21270	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
LVIS_RS21275	COG1132	(ABC) transporter
LVIS_RS21280	COG1846	Transcriptional regulator
LVIS_RS21300	COG1131	(ABC) transporter
LVIS_RS21305	COG1725	Transcriptional regulator
LVIS_RS21315	COG0386	Belongs to the glutathione peroxidase family
LVIS_RS21325	COG2814	Major facilitator Superfamily
LVIS_RS21330	COG0561	phosphatase activity
LVIS_RS21345	COG4221	oxidoreductase activity
LVIS_RS21350	COG1733	regulation of RNA biosynthetic process
LVIS_RS21355	COG1302	Protein conserved in bacteria
LVIS_RS21360	COG1302	Protein conserved in bacteria
LVIS_RS21375	COG2261	transglycosylase associated protein
LVIS_RS21420	COG0436	Aminotransferase
LVIS_RS21430	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LVIS_RS21435	COG2235	arginine
LVIS_RS21440	COG1288	antiporter activity
LVIS_RS21445	COG2205	protein histidine kinase activity
LVIS_RS21450	COG0784	Response regulator, receiver
LVIS_RS21455	COG1288	antiporter activity
LVIS_RS21460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LVIS_RS21490	COG2814	Major facilitator Superfamily
LVIS_RS21510	COG0588	phosphoglycerate mutase activity
LVIS_RS21520	COG0628	permease
LVIS_RS21525	COG1846	Transcriptional regulator
LVIS_RS21525	COG1940	carbohydrate kinase activity
LVIS_RS21535	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LVIS_RS21570	COG1511	domain protein
LVIS_RS21575	COG1686	Belongs to the peptidase S11 family
LVIS_RS21590	COG0516	GMP reductase activity
LVIS_RS21590	COG0517	IMP dehydrogenase activity
LVIS_RS21605	COG0012	GTP binding
LVIS_RS21610	COG4481	Protein conserved in bacteria
LVIS_RS21615	COG1475	DNA binding
LVIS_RS21620	COG1192	Involved in chromosome partitioning
LVIS_RS21630	COG0357	Ribosomal RNA small subunit methyltransferase G
LVIS_RS21650	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LVIS_RS21665	COG0702	epimerase
LVIS_RS21725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LVIS_RS21730	COG0583	DNA-binding transcription factor activity
LVIS_RS21775	COG0352	thiamine-phosphate diphosphorylase activity
LVIS_RS21780	COG0351	phosphomethylpyrimidine kinase
LVIS_RS21785	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
LVIS_RS21790	COG0300	oxidoreductase activity
LVIS_RS21795	COG0390	transport system, permease component
LVIS_RS21800	COG4619	ABC transporter
LVIS_RS21805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LVIS_RS21815	COG0789	Transcriptional regulator
LVIS_RS21845	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LVIS_RS21850	COG1418	mRNA catabolic process
LVIS_RS21870	COG1396	sequence-specific DNA binding
LVIS_RS21885	COG1114	Component of the transport system for branched-chain amino acids
LVIS_RS21895	COG0531	amino acid
LVIS_RS21900	COG1114	Component of the transport system for branched-chain amino acids
LVIS_RS21930	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LVIS_RS21945	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
LVIS_RS21960	COG2244	polysaccharide biosynthetic process
LVIS_RS21965	COG1476	TRANSCRIPTIONal
LVIS_RS21970	COG1506	peptidase
LVIS_RS21970	COG0823	Involved in the tonB-independent uptake of proteins
LVIS_RS21970	COG4946	Tricorn protease homolog
LVIS_RS21975	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LVIS_RS21985	COG1393	Belongs to the ArsC family
LVIS_RS21990	COG0025	NhaP-type Na H and K H
LVIS_RS21995	COG0737	Belongs to the 5'-nucleotidase family
LVIS_RS22020	COG1609	Transcriptional regulator
LVIS_RS22030	COG4475	Protein of unknown function (DUF436)
LVIS_RS22040	COG0351	phosphomethylpyrimidine kinase
LVIS_RS22045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LVIS_RS22050	COG1316	TRANSCRIPTIONal
LVIS_RS22070	COG0772	Belongs to the SEDS family
LVIS_RS22095	COG1940	carbohydrate kinase activity
LVIS_RS22110	COG2076	Multidrug Resistance protein
LVIS_RS22115	COG2076	Multidrug Resistance protein
LVIS_RS22160	COG4166	transmembrane transport
LVIS_RS22175	COG1609	Transcriptional regulator
LVIS_RS22185	COG0366	Alpha amylase catalytic
LVIS_RS22205	COG1902	pentaerythritol trinitrate reductase activity
LVIS_RS22210	COG1733	regulation of RNA biosynthetic process
LVIS_RS22225	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LVIS_RS22255	COG1881	PFAM PEBP family protein
LVIS_RS22270	COG0577	efflux transmembrane transporter activity
LVIS_RS22280	COG2814	Major facilitator Superfamily
LVIS_RS22295	COG0281	malic enzyme
LVIS_RS22300	COG0583	DNA-binding transcription factor activity
LVIS_RS22320	COG2957	Belongs to the agmatine deiminase family
LVIS_RS22325	COG0531	amino acid
LVIS_RS22330	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LVIS_RS22335	COG1757	Na H antiporter
LVIS_RS22340	COG0531	amino acid
LVIS_RS22365	COG0183	Belongs to the thiolase family
LVIS_RS22390	COG2261	transglycosylase associated protein
LVIS_RS22400	COG2207	Transcriptional regulator
LVIS_RS22410	COG3022	response to hydroperoxide
LVIS_RS22415	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LVIS_RS22420	COG0284	orotidine-5'-phosphate decarboxylase activity
LVIS_RS22425	COG2814	Major facilitator Superfamily
LVIS_RS22435	COG2267	carboxylic ester hydrolase activity
LVIS_RS22440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LVIS_RS22450	COG1397	ADP-ribosylglycohydrolase
LVIS_RS22455	COG2188	Transcriptional regulator
LVIS_RS22475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LVIS_RS22485	COG1309	transcriptional regulator
LVIS_RS22500	COG0110	maltose O-acetyltransferase activity
LVIS_RS22540	COG2826	transposase and inactivated derivatives, IS30 family
LVIS_RS22560	COG3842	ATPase activity
LVIS_RS22570	COG3250	beta-galactosidase activity
LVIS_RS22575	COG1959	2 iron, 2 sulfur cluster binding
LVIS_RS22600	COG1917	Cupin 2, conserved barrel domain protein
LVIS_RS22600	COG4977	sequence-specific DNA binding
LVIS_RS22610	COG1074	ATP-dependent DNA helicase activity
LVIS_RS22615	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
LVIS_RS22620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LVIS_RS22625	COG0726	polysaccharide deacetylase
LVIS_RS22640	COG0667	Aldo Keto reductase
LVIS_RS22645	COG2252	PERMEase
LVIS_RS22650	COG1846	Transcriptional regulator
LVIS_RS22670	COG4485	Bacterial membrane protein, YfhO
LVIS_RS22700	COG2211	Major facilitator Superfamily
LVIS_RS22705	COG2207	Transcriptional regulator
LVIS_RS22760	COG2814	Major facilitator Superfamily
LVIS_RS22770	COG1607	acyl-coa hydrolase
LVIS_RS22775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LVIS_RS22785	COG1114	Component of the transport system for branched-chain amino acids
LVIS_RS22795	COG1011	Hydrolase
LVIS_RS22810	COG0445	tRNA wobble uridine modification
LVIS_RS22815	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LVIS_RS22825	COG0706	membrane insertase activity
LVIS_RS22830	COG0594	ribonuclease P activity
LVIS_RS22875	COG0187	DNA topoisomerase II activity
LVIS_RS22940	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner